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This week's column is taken from the homily offered by Bishop Robert C. Morlino at the Chrism Mass on Tuesday, March 18th.
At this Chrism Mass, in a very focused way, the whole Church asks all priests to renew their commitment to serve you, God's people, whom the priests love so much and whom they know deserve to be served well. And we thank God for our many priests, for their selfless sacrifice and service to the Church and we thank God for our many seminarians, who are considering God's call to serve the Church. We ask the Lord to bless our priests and to continue to provide vocations to the priesthood and the religious life. But, at the Chrism Mass we focus especially on the priesthood.
At the Chrism Mass, we also consecrate our sacred oils, which scripture repeatedly refers to as, "the oil of gladness," or, "the oil of joy." So, when we focus on the blessing of oils, as we celebrate the Church and our Sacramental life, we are celebrating joy and gladness, because we are celebrating the oil of gladness and joy.
The Holy Spirit gives us all of His twelve fruits. The first is charity and the second is joy! So, if we are going to be the Church and carryout our mission, we need to carry this oil, though which He bestows his fruits, throughout the diocese. And at this Chrism Mass I distribute the oils to the representatives of all our parishes. And when I distribute the oils, the Holy Spirit is distributing His joy! We don't just take the oils home to our parishes and put them in a nice and reverent place – we take the joy of the Holy Spirit home too and we enshrine it in our hearts, throughout the parish community, so that, when people see the oil and receive the oil in the Sacraments, they make the connection between what they are doing and the joy which the Lord bestowing upon them, through His Holy Spirit.
This is an oil of gladness; this is an oil of joy! This is the oil that bishops and priests are anointed with, the oil that all of you, the baptized, are anointed with in your Confirmation and Baptism. And those of us who might be seriously sick or preparing for serious surgery are anointed with the Oil of the Sick, which is also an oil of gladness and joy - which I, myself can attest brings a great deal of peace. The first time I received the Oil of the Sick, I could not believe the peace that took hold of my own heart. Even in that circumstance of preparing for serious surgery, the Oil of the Sick brought peace and gladness and joy.
But how does this oil of gladness work? What does this oil do for those who are Baptized, Confirmed, Ordained, or Anointed in their illness? How does it bring gladness and joy? It does so by bringing joy and gladness through leadership in the Church to the people of God. The bishop has a special role of leadership, unworthy though he is. But the bishop didn't start it – God did. And because he was anointed, the bishop's role of leadership is a role of joy. And so it is for the priest.
What then do the priests and the bishops do, anointed with that oil of gladness and joy? Above all, the bishop and the priest are leaders in building unity. And how do the bishops and the priests put into action the fruits of that anointing and build unity? They teach the truth of the faith so that all of God's people can be of one mind. Through their preaching and teaching, the bishops and the priests build unity of mind together. And, when it is truly present, unity of mind brings joy.
The bishops and the priests also celebrate the Eucharist and that brings unity of hearts, which brings joy and peace and gladness. And that is their role as builders of unity – teaching so that there might be a union of minds, sanctifying so that there might be a union of hearts, and governing so that all ministry in the Church works together in harmony. When there is that unity, then the oil of gladness and joy truly brings about joy – the joy that comes from harmony and from unity. People want joy. People want unity. We can even see this in our current political race; but, no politician – not McCain, not Hillary, and not even Barack, can bring about the unity and hope and joy we desire. They can't. Jesus Christ alone can bring about that unity and joy - Jesus Christ, the one who anoints us with the oil of joy and gladness and imbues us with his Holy Sprit.
In this connection, I have to say something about the office of the bishop. It is hard for the bishop to talk about the duties of his own office, because it always seems that when he does that, he is acting in his own self-interest. I don't want it to seem that way and I don't talk about being a bishop for personal reasons. But, on this night of the Chrism Mass, I have to reflect about the office of bishop – as someone who, himself, wanted to be a teacher at a seminary. I have to talk about it first because the priest carries out his duty of sanctifying through the Sacrifice of the Altar. Every Altar of any diocese belongs to the bishop of that diocese. Every Altar is his, through his authority, given by Jesus Christ. And when the priest comes to the Altar, he comes as the representative of Christ and as the delegate of the bishop. Do I think that I am giving the priests a big gift, because they come to the Altar? No, I need them desperately to come to the Altar. I need you, my brother priests, desperately to come to the altar; I don't think I'm giving any big gift. The Church would not "work" if you didn't selflessly come to the Altar every day! And I need you to do that. But, the Altar is the bishop's Altar to give. He doesn't give it out of the "goodness of his heart;" he gives it out of his deep need for help from the priest.
In the same way, the pulpit, the tool of teaching, is the bishop's to give. Again, the bishop doesn't give the pulpit out of the "goodness of his heart!" He gives it out of his deep need for priests to teach the Truth. And in the same way, every confessional in the diocese belongs to the bishop. I don't give the faculty to hear confessions, the authority to forgive sins, because I'm generous; the bishop does so because he could not possibly, himself, be the minister of God's Mercy to every person in the diocese who needs mercy.
Whether he is worthy or not, the bishop is a successor to the Apostles and is given the duty to teach, sanctify, and govern. And the bishop, not out of any largesse of his own, but out of necessity, invites priests to be his helpers in teaching, sanctifying, and governing! And that's who the priest is, the faithful collaborator, with the bishop, in teaching, sanctifying, and pastoring God's people. I need you, brother priests, so very much. And I thank you for all that you do, day in and day out, so that the Church can "happen" in the Diocese of Madison.
There is always the temptation to think of the Church as a multi-national corporation, with the Pope as the CEO and the bishops as branch managers of sorts. But, if we think this way, then we start to think of leadership styles which amount to consensus building. In a multi-national corporation that has set a very narrow mission, consensus building is easy - you simply determine the mission and then fire those who do not agree. But, it is not that way in the Church, we're not about firing people who don't agree – we are about loving people into agreement. That's what we do. However, if a corporation has a very broad mission, which the Church does, the only way to arrive at a consensus, in this multi-national corporate model is to "agree to disagree." And that's how we talk in our culture, in our time – we agree to disagree (respectfully, of course!). We have an unbelievably broad mission in the Church. We are called to bring everyone in – if at all possible. But agreeing to disagree, which is the only way to function in a multi-national corporation if you have a broad mission, will not work in the Church!
Agreeing to disagree does not bring unity! So this model of a multi-national corporation does not apply to the Church. The oil of gladness is mystical, and it calls the Church to do far better than simply agreeing to disagree. It calls us to build a unity of minds and hearts and it calls us to a pastoring that really brings our people joy and gladness. That's what you and I, my brother priests, are called to do, so that our people, who are then anointed with the oil of joy and gladness, can take up leadership in the world and try, in the world, to build unity of minds and hearts.
We are not a bunch of politicians or political parties. Agreeing to disagree is not enough for us. That union of minds and hearts which Christ intends is much, much deeper. And only when we have that union can we fully experience the fruits of the oil of gladness and joy, which Christ himself desired when, through the Holy Spirit, He instituted the Sacraments.
So, dear brother priests, dear sisters and brothers and Christ, let's not ever be tempted to simply seek the consensus that we can build by agreeing to disagree. Let us commit ourselves again to receiving the gift of the consensus that comes from the Holy Spirit, through the oil of gladness and joy. For, only when we accept that consensus that comes from the Holy Spirit, through the teaching of the Church, through our union – Pope, bishops, priests, deacons, all of the consecrated and lay faithful – only then will the oil of joy and gladness have its deepest effects in our hearts. So, let us be people of joy and people of unity, that the mission given us by Christ might be done. Let us rededicate ourselves to being people of gladness and joy; that's the gift that God wants to give the world through all of you, and that's the gift that God wants to give the Church through bishops and priests. Let it be so.
Praised be Jesus Christ!
* Catholic News Agency columns are opinion and do not necessarily express the perspective of the agency.


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Sit yourself in a pew in Augustine's church and listen to the great church father preach to you the soaring beauty of the first epistle of John....
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"American Horror Story" Season 3 has added yet another familiar face.
On twitter (via The Hollywood Reporter), "American Horror Story" co-creator Ryan Murphy wrote "So thrilled to announce Lily Rabe is onboard for 'American Horror Story' Season Three! So talented, love her!"
During the first season of "American Horror Story," Rabe had a small role as Nora Montgomery, the ghost of a previous resident of the Murder House. In "American Horror Story: Asylum," Rabe had a much bigger part as Sister Mary Eunice, a sweet and innocent nun who became one of the series' most memorable villains when she was possessed by the devil.
Prior to her stint on "American Horror Story," Rabe made guest appearances in "Law & Order: Criminal Intent," "Nip/Tuck," "Medium" and "The Good Wife" in addition to roles in Mona Lisa Smile, All Good Things, Aftermath and No Reservations.
Joining Rabe for their third season on "American Horror Story" are Sarah Paulson, Evan Peters and Jessica Lange. Taissa Farmiga is also reportedly in talks to return to the series after sitting out during the second season.
As with the previous seasons, "American Horror Story" Season 3 will completely change the setting and the time frame of the story, with the cast assuming all new roles. All that is currently known about the new season is that it will be set during the present and that it will once again feature a Romeo and Juliet style romance.
"American Horror Story" Season 3 will haunt FX in October.


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Big rig trucks are dangerous. They cause serious injuries and they kill people. Our law firm is currently handling 5 wrongful death truck accident cases. It is beyond awful.
I think we have established this fact on this blog. What we have not talked about specifically is the risk to truck drivers. Driving a truck was the single most hazardous occupation in the United States last year, taking 852 lives. Logging that many hours on the road with vehicles that are tough to control… I'm surprised the number is not higher.
Large Truck Does Not Equal Large Uninsured Motorist Policy
Compounding this tragedy is the lack of uninsured motorist benefits for truck drivers. Commercial trucks have liability insurance requirements. Most trucks must be insured at a minimum of $750,000. (It is a crime that this cap has not be raised in the last zillion years but that is a whole different issue.)


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A young talent to watch
Sweet Briar's 2013-2014 Writers Series will continue with a reading by Leslie Jamison at 4:30 p.m. Monday, Oct. 7, in the Browsing Room at Mary Helen Cochran Library.
Jamison will read from and talk about "The Empathy Exams," a 2012 Graywolf Press Nonfiction Prize winner. The essay collection, due for publication in 2014, is Jamison's second book. The first, her novel "The Gin Closet," was written when she was 26 and established her as an emerging young writer to watch. It was a finalist for the 2010 Los Angeles Times First Fiction Award and one of the San Francisco Chronicle's best books of the year.
The essays in her second book "are about medical acting, ultra-runners, prison, an ultra-runner in prison, parasites, silver mines, gang tours, and — beyond and beneath all else — the possibilities, texture and limits of compassion," according to Jamison's biography.
Robert Polito, the director of the graduate writing program at the New School in New York, was an outside judge for Graywolf Press. He suggests her "stylish and audacious" writing can almost make you miss the wounds at its core.
" 'The Empathy Exams' is a book of surprises, and those surprises are so smart, so elegantly arranged, and so various that you almost forget, for instance, that Leslie Jamison's subject is pain," he said.
Nell Boeschenstein, who is new this year to Sweet Briar's creative writing program, is a fan of Jamison's work and extended the invitation to participate in the Writers Series.
"Leslie's writing is characterized by a profound curiosity of what it means to be human," she says. "Her work is deeply intelligent without ever being pretentious, and deeply kind without ever veering towards sentimentality."
Jamison, who has taught fiction and nonfiction at Yale University, Southern New Hampshire University, Wesleyan University and the Iowa Writers' Workshop, is looking forward to engaging with Sweet Briar students.
"I hope my writing can stir conversation but also — on some basic level — that it can stir feeling, and perhaps some thinking about how that feeling might be directed back out into the world," Jamison says.
Raised in Los Angeles, Jamison attended Harvard College and received an MFA in fiction from the Iowa Writers' Workshop. She is completing a doctorate in American literature at Yale. She also mentors through the PEN Prison Writing Program.
Her work has appeared in Harper's Magazine, A Public Space, The Believer, Oxford American, VICE, Tin House, The Paris Review Daily and elsewhere.
The reading is free and open to the public. For more information, email [email protected] or call (434) 381-6434.
Category: Creative Writing, English


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Colby Carnival alpine recap
UVM leads alpine at Colby Carnival
UVM pulled off another impressive alpine performance at the
Colby Carnival, and lead Dartmouth by over 100 points with the final day of
Nordic racing tomorrow.
The Catamounts pulled off a remarkable podium sweep in the
women's slalom today (January 26th) with Kristina Riis-Johanesen
taking another victory, Elise-Wolen Tefre in 2nd, and Kate
Ryley in third.
Slalom phenom, Johnathan Nordbotten (pictured right), put UVM on the top step
of the men's podium too, joined by fellow Catamount, Travis Dawson. David
Donaldson, kept the ball rolling with another podium, this time
2nd place, and Hunter Black from Dartmouth put in a solid day as well,
pulling in a fourth place for Dartmouth.
The men's GS was easily taken by UVM. They pulled off the
rare feat of putting four in the top-five, besting everyone, except of
course David Donaldson who took another win, and remains undefeated in EISA GS this season.
UVM wasn't so dominant in the women's giant slalom, but Kate
Ryley continued her undefeated GS tear, with her third win of the season. The 2012
NCAA champion from Harvard, Rebecca Nadler (pictured left), scored a 2nd, and Abigail
Fucigna a 3rd for Dartmouth. Bates celebrates a top-five as well, with Avril Dunleavy
in fourth.
Team scores leading into final day of Nordic competition:
-Article and photos by Jeremiah Johnson


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This step is up to you but will drastically multiply your chances of getting interest from other over 40s members on the site. Let people know a bit about yourself, your hobbies and atach your nicest photo of yourself.
Use our website's advanced search to discover over 40s members who match your desired criteria. Or just scan through listings and discover members that attract you.
Discovered someone who tickles your fancy? Send a message to them or just a wink and see if they're interested. With a little luck you'll be on your way to uncover your suitable match.
It's quick and easy


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Release Date: 1973 |
Album Rating: 4.0And there's ProgJect #25! We haven't been too active lately, but rest assured, the prog will not end.
Great work guys, pos'd.
I need to check this out, Phantasmagoria is great.
similar to airplane sweet
Album Rating: 4.0fuck yea at last, awesome review bros
Checking out as soon as possible.
Album Rating: 4.0Speaking of ''the unusual combination of instruments of the band'' at the 1st para and due to the fact that the edit function still hasn't be fixed, we need to add; flutes and trumpet
Thank you Nag, dear colleague. Once again, your magic touch turned out to make the difference.
@Jamie; I have no doubt you're gonna dig this. Same for you, tarkus and KILL. Cheers my friends.
Have a prog pos ProgJect team.
I read the review tomorrow.
Album Rating: 4.0Haha thanks so much for your confidence Notrap and above all, for your loyalty.
I can't go wrong with you guys. Review is top level for sure.
The review sucks. Have a pos.
Digging: Godspeed You! Black Emperor - Luciferian Towers
Album Rating: 4.0^Reported. Have a ban HA! =P
Cheers Notrap, bud.
Album Rating: 4.0Best Curved Air album IMO, Phantasmagoria being close second.
Album Rating: 4.0other way round for me but both rule hadr
Album Rating: 3.5Indeed Phantasmagoria is excellent, so I'll be looking into this in the near future. Thanks all.
great work guys!
band is really good, though I haven't wholly listened neither this nor Phantasmagoria.
keep up the good prog
Album Rating: 4.0Yes Nag, please do.
Thanks scissor, buddy.
Some great cuts on here:
Album Rating: 3.5^Metamorphosis sounds promising.
Album Rating: 4.0Metamorphosis is arguably the proggiest thing the band has ever done.
The short but effective 'The Purple speed Queen' wouldnt be out of place in any early Rush albums.
'Armin' is another outstanding track on here. In short, get the album, you wont regret.
Album Rating: 4.0metalmoarphisis
Album Rating: 4.0moar Phish
On a moar serious note, next ProgJect review is gonna be Locanda Delle Fate - Forse de Lucciole Non si Amano piu, one of the best Italian prog albums.
Bands: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z


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Hi, >How to run Postmaster with the -i option to allow remote connections? If you're running v7.2, in the $PGDATA/postgresql.conf file (usually either /usr/local/pgsql/data or /var/lib/pgsql/data), there's a line with: tcpip_socket = false change the false to true, restart postgresql and away you go :) If you have an older version, you'll have to edit the startup script, and change it to something like: pg_ctl -D $PGDATA -p /usr/bin/postmaster start -o "-i" (I think that's right, I use the first way so I'm guessing a little bit). HTH, Chris.
Next: From: Yannick ALLUSSE Date: 2002-03-07 07:56:49 Subject: Size of the empty database Previous: From: Faudzy Sulaiman Date: 2002-03-07 03:49:41 Subject: Postmaster with -i


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The Scrap Exchange in Durham is offering up a new series of weekly summer camps in June and July for kids ages 9 to 12.
The summer camp program emulates The Scrap Exchange's mission of promoting creativity, environmental awareness and community through reuse, according to a press release.
The program comes after the popular nonprofit's move last year to a new location in Durham, which offers an expanded Design Center, Make-n-Take Room, large outdoor space with basketball hoops and a community garden. Themes for the four week-long camps are Adventure Builders, Eco-Scouts, DIY Designers and Marketplace Makers.
"This is a chance for campers to learn lifelong skills and experience project-based collaborations through creative reuse," Executive Director Ann Woodward said in the release. "Helping children learn to think outside of the box about the reusing of resource materials help bring us into a more sustainable future."
Camps are held onsite at The Scrap Exchange, 2050 Chapel Hill Rd. in Durham. Half-day programs start at $125. The Scrap Exchange's website has more information about the camps, registration and scholarship opportunities.
Find more camps on our newly updated Go Ask Mom Camp Guide.


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Pros: Interesting plot at least.
Cons: The author gets her facts badly mangled, some lack of detail makes the story suffer.
I was cruising the bookstore the other evening looking for some new reads. This one was tucked away in a corner, the gold stamping on the cover pulling me a bit closer. When I saw the title, I grabbed it up, having had a fascination with the Tudors ever since I was a young teenager. I had tried reading some of the author's previous work -- most notably A Respectable Trade, but I had been badly disappointed by her lack of style and color.
I should have known better and put it right back down on the display. Right from the start, we get a picture of the glamourous Tudor court that's a bit askew and downright wrong in spots. Taking the story of Anne Boleyn, the second of King Henry VIII's many wives, and the first to lose her head, author Philippa Gregory tells the storry from the point of view of her younger sister, Mary.*
This first person account shows a child bride** being pushed by her family to hop into the king's bed. Hardly any mention is made of her first husband, William Carey, he's there to show that Mary was 'respectable.' We get to see Mary falling head over heels for King Henry, and a rather passionless affair, with Mary being more of a dupe and a twit than anyone with any sort of brains.
Gregory draws on the writings of scholar Retha M. Warnicke for her portrayal of the Boleyn family. Although Warnicke's books are excellent studies of the Tudor court, some of her conclusions are regarded with some skepticism -- one of the main plot lines in this book is the closeness that existed between Anne and her brother, George. One of the charges that was brought at Anne's treason trial was that of incest, as well as adultery and hints of sorcery. Gregory has decided to use these as fact.
And it is that, the distortion of history in favor of skewing the view to her own plot devices that makes this novel fall apart. I know that authors, especially those who write historical fiction, are expected to take certain liberties, but this was so badly done here that it made the book laughable rather than a pleasant excursion into a dramatic life spent in a glittering court. Mary Boleyn in this plays the part of the ultimate victim and 'good girl', with the character of her sister, Anne, drawn with such a wide brush that there's very little to like about her at all.
For a much better novel of the same subject and story, if in a lighter, more traditionally romantic style, I would suggest Karen Harper's Passion's Reign,, recently reprinted as The Last Boleyn or the more scholarly and entertaining works by Alison Weir. For something out a bit in left field, but no less the entertaining (and at least the facts are right) try on Kathryn: In the Court of Six Queens for a similar treatment.
I seriously doubt that any editor took a hard look at this manuscript to check out the details, and just rubber stamped it. Although the story and the character of Mary does get more interesting later on, it's still a dud and not worth it. Comes with an author's note and bibliography as well as a discussion guide and Q&A with the author.
* Flaw number one -- It's a well-known historical fact that Mary was the elder, not younger sister, of Anne Boleyn. And that Mary spent a number of years at the court of Francois I, and evidently was a great favorite of the gentlemen there, as ambassador's documents show that she was described as la grande putaine. Gregory conveniently skips over this detail. In fact, it might have been Mary's experiences that may have driven Anne to hold out being a wife and queen, rather than just a king's mistress.
** Flaw number two -- Mary was wed well after she returned from France, not as a child of eleven or twelve. Although child betrothals and marriages were fairly common, it wasn't usual to be consummated until well after puberty hit.
Other novels by Philippa Gregory set in the reign of Henry VIII:
The Constant Princess -- Katharine of Aragon
The Boleyn Inheritance -- Anne of Cleves and Katherine Howard


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The Blueprint for a Secure Energy Future outlines a three-part strategy:
- Develop and Secure Americas Energy Supplies: We need to deploy American assets, innovation, and technology so that we can safely and responsibly develop more energy here at home and be a leader in the global energy economy.
- Provide Consumers With Choices to Reduce Costs and Save Energy: Volatile gasoline prices reinforce the need for innovation that will make it easier and more affordable for consumers to buy more advanced and fuel-efficient vehicles, use alternative means of transportation, weatherize their homes and workplaces, and in doing so, save money and protect the environment. These measures help families pocketbooks, reduce our dependence on finite energy sources and help create jobs here in the United States.
- Innovate our Way to a Clean Energy Future: Leading the world in clean energy is critical to strengthening the American economy and winning the future. We can get there by creating markets for innovative clean technologies that are ready to deploy, and by funding cutting-edge research to produce the next generation of technologies. And as new, better, and more efficient technologies hit the market, the Federal government needs to put words into action and lead by example.


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Stage 21 winner.
Stage 21 winner.
"My strategy was to start sprinting not too early. Alexander Kristoff passed me so he had more time to accelerate and gain some speed. That's why I was a bit behind and I accelerated, accelerated... till the moment Kristoff could not accelerate anymore. I was not sure it would be enough to beat him. I'm happy with how it went. This time, my lead out man Tom Veelers was able to accompany me till the end of the Tour in Paris without crashing before. We need him! In the preparation of the sprint I thought he was gone but when I saw him passing me, I said to myself: now we're unbeatable.
This is the second time I win the first and last stage of the Tour de France, at least I can say it means a lot to be able to win such an important amount of stages as a team and I belong to the group of the fastest guys. You can count on me when the race comes down to a sprint. Mistakes can always happen like it did in Reims, but overall, we've done a very good job at the Tour again this year.
Right now, I don't want to think of my future too much. I want to enjoy the moment. My goals won't change in the future, especially at the Tour de France. I'll go again for stage wins but I'm not a man of records. I've said in the past and I repeat that the green jersey can become an option in the future.
One record broken this year is seven stage wins by German riders. I think it's a big signal to all the fans in Germany, to the German media without too much into details in that area. I'm proud of the performances of my compatriots and myself but please don't forget the two second places of John Degenkolb. At half of the stages, there have been Germans in the top three. It shows that German cycling is part of the top of the cycling world. It's awesome."


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Joop Chill Out Cologne
By Joop! for Men
Joop Chill Out Cologne by Joop!, with top notes of bergamot, lemon and cinnamon; and a heart of exotic fruits, watery fruits and pineapple and a base of muguet, heliotrope, orange flowers, vetiver, patchouli, sandal, vanilla and tonka bean. All products are original, authentic name brands. We do not sell knockoffs or imitations. ... Read More
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D. Bakare (Kent, GB)


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Phase 2 Study of Oral IXAZOMIB in Adult Patients With Relapsed and/or Refractory Follicular Lymphoma
This study has been completed.
Millennium Pharmaceuticals, Inc.
Information provided by (Responsible Party):
Takeda ( Millennium Pharmaceuticals, Inc. )
ClinicalTrials.gov Identifier:
First received: August 28, 2013
Last updated: March 28, 2017
Last verified: March 2017
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This is an open-label, multicenter, phase 2 study to evaluate the efficacy and safety of oral IXAZOMIB in adult patients with follicular lymphoma (FL) that is relapsed and/or refractory to prior treatment.
|Follicular Lymphoma
|Drug: IXAZOMIB
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|An Open-label, Multicenter, Phase 2 Study of Oral IXAZOMIB (MLN9708) in Adult Patients With Relapsed and/or Refractory Follicular Lymphoma
Resource links provided by NLM:
MedlinePlus related topics: Lymphoma
Drug Information available for: Ixazomib Ixazomib citrateU.S. FDA Resources
Further study details as provided by Takeda ( Millennium Pharmaceuticals, Inc. ):
Primary Outcome Measures:
- Overall Response (Complete Response (CR) + Partial Response(PR)) Rate (ORR) [ Time Frame: Time from the start of treatment to the occurrence of disease progression, unacceptable toxicities, or discontinuation of study due to any other reasons (up to approximately 24 months) ]
Secondary Outcome Measures:
- Recommended Phase 2 Dose (RP2D) [ Time Frame: Approximately 8 months after dosing the first patient ]
- Progression Free Survival (PFS) [ Time Frame: Up to a total of 24 months after first dose or until disease progression, withdrawal from study, or death ]
- Rate of Disease Control [ Time Frame: Time from the start of treatment to the occurrence of disease progression, unacceptable toxicities, or discontinuation of study due to any other reasons (up to approximately 24 months) ]
- Time to Response (TTR) [ Time Frame: Time from the date of registration to the date at which the patient's objective status is first noted to be a CR or PR (assessed up to approximately 24 months) ]
- Duration of Response (DOR) [ Time Frame: Time from the date at which the patient's objective status is first noted to be a CR or PR to the earliest date progression is documented (assessed up to approximately 24 months) ]
- Response rates in FL patients positive versus negative for the proteasome subunit beta type-1 (PSMB1) polymorphic marker [ Time Frame: Time from the start of treatment to the occurrence of disease progression, unacceptable toxicities, or discontinuation of study due to any other reasons (up to approximately 24 months) ]
- Number of participants with Adverse Events (AE) or Serious Adverse Events (SAE) [ Time Frame: Signing of informed consent through 30 days after last dose ]
- Plasma PK parameters including Maximum Concentration (Cmax), Single-dose time to reach maximum plasma concentration (Tmax), Area under the plasma concentration versus time curve (AUC) from zero to time of last quantifiable plasma concentration (AUClast) [ Time Frame: Days 1-3, 5, 8, 15-17, 19 and 22 during Cycle 1 and Day 1 during Cycles 2-4 of each lead-in dose finding cohort ]
|Actual Study Start Date:
|October 31, 2013
|Study Completion Date:
|March 23, 2017
|Primary Completion Date:
|June 1, 2016 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: IXAZOMIB
Drug: IXAZOMIB
Each 28-day treatment cycle will include oral administration of IXAZOMIB on Days 1, 8, and 15 followed by a rest period of 13 days.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Male or female patients 18 years or older
- Patients must have a pathologically confirmed diagnosis of non-Hodgkin lymphoma (NHL) (for the lead-in dose-finding phase) and FL (for phase 2)
- Patients must have radiographically or clinically measurable disease
- Patients must be relapsed and/or refractory after at least 1 prior therapy (excluding radiation) with documented progressive disease at the time of enrollment
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
- Female patients who are post menopausal, surgically sterile, or agree to practice 2 effective methods of contraception or agree to practice true abstinence
- Male patients who agree to practice effective barrier contraception or agree to practice true abstinence
- Voluntary written consent
- Suitable venous access
- Appropriate clinical laboratory values as defined in the protocol
- Recovered from toxicities of prior anticancer therapy
- If the trial proceeds to the second step on the basis of the tandem 2-step design, patients must be confirmed PSMB1 positive at the central laboratory before treatment
Exclusion Criteria
- Peripheral neuropathy that is greater or equal to Grade 2 or Grade 1 with pain
- Female patients who are lactating and breastfeeding or have a positive serum pregnancy test during the Screening period
- Autologous stem cell transplant within 6 months before Day 1 of Cycle 1, or prior allogeneic stem cell transplant at any time
- Major surgery within 14 days before the first dose of study drug
- Infection requiring systemic antibiotic therapy or other serious infection within 14 days before the first dose of study drug
- Comorbid systemic illnesses or other severe concurrent disease that, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens
- Evidence of current uncontrolled cardiovascular conditions including uncontrolled hypertension, severe uncontrolled ventricular arrhythmias, unstable angina, New York Heart Association (NYHA) Class III or IV cardiac disease, or myocardial infarction within the past 6 months
- Diarrhea > Grade 1 on the basis of the NCI CTCAE categorization
- Systemic antineoplastic (including glucocorticoids > the equivalent of 15 mg of prednisone daily), experimental, or radiation therapy within 21 days before the first dose of study drug
- Prior treatment with rituximab or other unconjugated antibody treatment within 42 days (21 days if clear evidence of progressive disease or immediate treatment is mandated)
- Treatment with radioimmunoconjugates or toxin immunoconjugates within 12 weeks before the first dosing of study treatment
- Systemic treatment with strong inhibitors of CYP1A2 or CYP3A, or strong CYP3A inducers within 14 days before the first dose of IXAZOMIB - Ongoing systemic therapy with corticosteroids
- Central nervous system (CNS) involvement that is clinically uncontrolled or newly diagnosed in the last 4 months
- Ongoing or active systemic viral infection, known human immunodeficiency virus(HIV) positive, known active hepatitis B virus or known active hepatitis C virus
- Diagnosed or treated for another malignancy within 2 years before study enrollment or previously diagnosed with another malignancy and have any evidence of residual disease with the exception of nonmelanoma skin cancer or any completely resected carcinoma in situ
- Platelet transfusions within 3 days before the 1st dose of study drug
- Inability to swallow capsules, or inability or unwillingness to avoid taking anything by mouth except for water and prescribed medication for 2 hours before and 1 hour after dose of IXAZOMIB - Known allergy to boron or excipients in the formulation
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01939899
Please refer to this study by its ClinicalTrials.gov identifier: NCT01939899
|United States, Massachusetts
|Boston, Massachusetts, United States
|United States, New York
|New York, New York, United States
|United States, Tennessee
|Nashville, Tennessee, United States
|United States, Texas
|Houston, Texas, United States
|Gent, Belgium
|Leuven, Belgium
|Wilrijk, Belgium
|Canada, Quebec
|Montreal, Quebec, Canada
|United Kingdom
|London, United Kingdom
|Manchester, United Kingdom
|Newcastle Upon Tyne, United Kingdom
|Plymouth, United Kingdom
|Southampton, United Kingdom
|Sutton, United Kingdom
Sponsors and Collaborators
Millennium Pharmaceuticals, Inc.
|Study Director:
|Medical Monitor
|Millennium Pharmaceuticals, Inc.
More Information
Keywords provided by Takeda ( Millennium Pharmaceuticals, Inc. ):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 19, 2017
|Responsible Party:
|Millennium Pharmaceuticals, Inc.
|ClinicalTrials.gov Identifier:
|NCT01939899 History of Changes
|Other Study ID Numbers:
2013-002302-32 ( EudraCT Number )
U1111-1164-7551 ( Registry Identifier: WHO )
166547 ( Registry Identifier: HC-CTD )
REec-2016-2137 ( Registry Identifier: REec )
13/EM/0373 ( Registry Identifier: NRES )
|Study First Received:
|August 28, 2013
|Last Updated:
|March 28, 2017
Keywords provided by Takeda ( Millennium Pharmaceuticals, Inc. ):
Additional relevant MeSH terms:
Lymphoma, Follicular
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Lymphoma, Non-Hodgkin
Antineoplastic Agents
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Glycine Agents
Neurotransmitter Agents
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 19, 2017


text:
GUILDERLAND, N.Y.–Five Guilderland High School senior athletes will announce their college intentions on Wednesday.
Soccer players Emily Center, Kledis Capollari, and Connor O'Brien will be on hand along with Abby Marco from the track and field team and Jenna Robinson from the cross country team.
The press conference will take place at Guilderland High School in the New Gym Lobby at 3:45 p.m.


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Zac Brown Band Hoping for More 'Grohl Sessions'
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