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Spent some time last week working on a script to verify that the printer actually works when printing from an application to OneNote. I learned a little something about our OneNoteOfflineCache_Files that I thought may be interesting as well. I'll start with that.
The OneNoteOfflineCache_Files folder is a stored in the subfolder of the OneNote cache. You can see where that is by looking in Tools | Options and examining the Save tab. If you have OneNote 2010, you can see this in File | Options and looking at the Save & Backup tab. This is what it looks like on my XP machine:
The folder that I need to work with is named "OneNoteOfflineCache_Files" and would be a subfolder under this path. So the full path in this case would be C:\Documents and Settings\johngui\Local Settings\Application Data\Microsoft\OneNote\14.0\OneNoteOfflineCache_Files.
If you jump to that folder now you will probably see a ton of files named {GUID}. I'll come back to that.
What I want this particular code to do is verify the proper set of files get added to that folder when I insert a printout. When I insert any document into OneNote (as an embedded file), a copy of it gets created here with a {GUID} for a name. OneNote uses this as a cached copy of the actual file - in case you want to view it when you are disconnected from the network, for instance. Embedded images also get save here. We give the file a GUID to help prevent "name collisions." Imagine the trouble if you had 20 files named "readme.txt" added from all over - we'd need some method to find out which one you meant to open if you clicked the icon in OneNote. We just renamed the cached copy to a {GUID} to help prevent this type of problem.
Moving on to printing, if I print a text document that is 2 pages long to OneNote, I should get 2 images added to that folder- one for each page. I also get a third image added to show as the icon for the icon type of the embedded file. It should be a text file in my case (I'm going to print a plain text document here to start). I should also get a copy of the text file since it will get added as an embedded file as well. And I should get an XPS file since the OneNote printer prints to the XPS printer and just uses its output. So printing this document should add 5 total files to that folder - 3 image files (PNG), 1 text file and 1 XPS file.
Our automation system automatically ensures a clean machine when we run, and the setup part of this script creates a barebones notebook with a single blank page ready for testing. I did not change any of that and wrote the script to print the text file to OneNote and ensured that the number of PNG files when done was 3, text files was 1 and XPS files was 1. And the script failed.
Here's where I learned something new (you learn something new every day around here). I looked in the folder and noticed 70 some odd files were there. Thinking there was a bug in the setup for the test code, I deleted them all and restarted. And they came back. I opened a few of the PNG files and they looked like the backgrounds from some of the default templates. It turns out that is exactly what they are - the images from the templates. They get cached here so they can be more quickly accessed when OneNote is running.
Since I don't care about templates for this particular test, I wrote a routine to clean the folder right before my test runs. Now this file check verification works just fine.
I strongly DO NOT recommend deleting this files. All your embedded items in a notebook will be broken. This is a good example, though, of where automation need not simulate a regular user to perform a verification.
More on that later.
Questions, comments, concerns and criticisms always welcome,


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Most Days....most days for me..........the freakin' tree outside my window can amuse me for hours on end.....
hell right now i am writing this, watching that stupid Guinea pig run across the floor, laughing my *** off........stupid thing. how does it escape from its damn cage ? well, it is, very amusing............yup, running guinea pigs are funny ! lmao ! I am too lazy to get up and chase it around, *hey Bella, get back in your cage!* .....................................nope .....didn't work. Yes, easily amused..........that's me :)
hartleybroken 22-25, F 3 Responses 4 Jul 8, 2010
I love to watch the cat of the house next to my building, he is so lazy, I call him Cooky, I don't know how is his real name, and I called his owners Perla & Pedro, don't know their names either . My sister and I call him from the window and send him kisses and he just look at us like, ''what tha **** are you trying to do, leave me alone!'' and falls asleep in the act, hahaha, he's so adorable
I like to watch my horny cat roll around, makes me laugh....stupid **** cat.

subset: commoncrawl


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Monday's Early Headlines
- Obama Budget Pushes Deficit to Record Level -- President Obama unveiled his budget Monday designed to combat job woes in he U.S. The budget, which carries a price tag of $3.83 trillion, will push the deficit to a record $1.56 trillion. The deficit would remain above $1 trillion next year, although proposals were made for a tax boost for the wealthy and a three-year freeze on government spending outside of military and homeland security.
- Toyota Gas Pedal Fix to Begin This Week -- Toyota (TM) said Monday it would begin fixing accelerator pedals in recalled cars this week. Toyota is recalling up to 9 million cars worldwide, including 2.3 million in the U.S and Canada, and has halted production of eight cars in the U.S., while it sought to determine how to fix the problem. Toyota said Monday parts to reinforce the pedals are already being shipped to dealers and dealer training has begun. "We know what's causing the sticking accelerator pedals, and we know what we have to do to fix it," said Jim Lentz, president and chief operating officer of Toyota Motor Sales U.S.
- Citigroup to Sell Private-Equity Unit: Report -- Citigroup (C) plans to sell or split off its $10 billion Citi Private Equity unit as part of the bank's effort to reduce debt, according to a Bloomberg report. The unit's managers have discussed buying Citi Private Equity themselves along with new partners or with other financing, the report said. Citigroup's decision to sell Citi Private Equity was made last year, before President Barack Obama in January proposed banks be forced to unload their private-equity firms and hedge funds, the people familiar with the matter said, Bloomberg adds.
- Disney Reportedly Seeks Sales of Miramax -- Disney (DIS) is seeking a buyer for what remains of its beleaguered Miramax film unit which could fetch in excess of $700 million, The New York Times reports. The sale could come within a few months, said a mergers and acquisitions expert with knowledge of the process
- Amazon Gives In to Higher E-Book Prices -- Amazon.com (AMZN) has agreed to sell electronic versions of its books at prices it considers too high, giving in to publisher Macmillan. Amazon over the weekend pulled titles from Macmillan off its Web site because of a pricing dispute after Macmillan and other publishers worked out a new e-book pricing scheme for Apple's (AAPL) new iPad. Amazon said Sunday it was in "strong disagreement" with MacMillan's plan to sell e-books at $12.99 to $14.99 when first released, with prices dynamic over time.


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Today, Sony announced a price drop for the PlayStation 3 at Gamescom in Cologne, Germany. Effective immediately, the PlayStation 3 will now cost $249.99 from $299.99 (249 Euros, 24,980 Yen). For those who aren't so hot at math, that's a $50 price slash. This new price point should make the system more enticing to those who are still on the fence about buying one (Spoiler: you shouldn't be). This new price point is effective immediately, by the way.
The drop in price of the PS3 is a smart business decision that should move quite a few units this holiday season, especially in light of all the Sony exclusives that are set to release throughout the remainder of the year — Resistance 3, Uncharted 3: Drake's Deception, God of War: Origins Collection, Ico/Shadow of the Colossus HD Compilation to name a few.
On top of all the great games that make up the Sony exclusive catalogue, the PS3 is also a fantastic blu-ray player. So if you're looking to finally buy into the high definition era, the PS3 is a great device to make that commitment with.
So, if you were on the fence about buying a PS3 before, does this new price point change your mind? Let us know in the comments below.


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I wanted my outward appearance to reflect my inward state - I feel young and vital at 56 but the sun and time had taken its toll. Facial surgery was the answer for me.
Dr Shapiro is a True Artist... - Scottsdale, AZ
I wanted my outward appearance to reflect my...
I went for 12 consultations (two in NYC, two in PA and eight in AZ) before trusting my face to a surgeon. The moment I met Dr. Shapiro my search was over - we had an instant connection. He was extremely confident in his abilities and could 'see my vision' in addition to his own. I had a full face lift, upper and lower eyes & brow lift in addition to a mini tummy-tuck. All I can say is the results far surpassed anything I could have imagined and I am only three weeks post-op. Dr. Shapiro took a lot of time with me before and after surgery. His staff was extremely knowledgable and accommodating. The actual surgery center was amazing...a special thanks to Nurse Betty - I felt nurtured and cared for at the recovery center. If you have been searching for a PS, please consider Dr. Shapiro - He is a gifted and talented surgeon - a true artist. Thanks to all!


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Kettering Medical Center KPN MEDICAL ASST in Hamilton, Ohio
Assists physician in examinations. Give instructions to patients as instructed by physician. Takes blood pressure, pulse, temperature, and respiration. Stock rooms with adequate medical supplies, washes and dries instruments, and prepares sterilization as required. Assist with any procedures that have been taught through formal training or by licensed nurse or physician(s). Keeps medical records in accordance to procedures and forms. Follows principles of medical ethics.
Must either have six months experience as a Medical Assistant, OR, have graduated from an accredited MA or Medical Office Management program that meets nationally accepted standards. Within one year from date of hire, continued employment will require successful attainment of MA, RMA, CCMA, CMA (AAMA), or NCMA certification. Must also be willing to accept orders and perform repetitive tasks.
Requisition Number: 16-7256
Title: KPN MEDICAL ASST
Department: KETT GASTROENTEROLOGY - 783686
Location: Kettering Health Physician Network
State: OH
City: Hamilton
Shift: First
Job Status: Full-Time
Temporary: No
Hours per Bi-Weekly Pay Period: 80


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Oswego fishermen talk about river safety
Thu, 07 Oct 2010 03:46:17 GMT —
A panel of state and local agencies wanted to hear ideas to improve safety in the Oswego River from those affected most " fishermen. Many of the fishermen had questions of their own to ask as well. Several people at the meeting in downtown Oswego wanted more information from Brookfield Power about why rising water alarms at the Varick dam hadn't gone off for the 45 minutes before the water went up quickly on September 28th. Two fishermen died after they were swept down the Oswego River by high waters. Rick Hayden said he believes the timing of the high water alarm needs to improve.
"It has to work, said Hayden. When the water's coming up - we want the alarm on."
The dam's safety manager refused to answer questions at the meeting but said he wanted to listen to what the experienced fishermen had to say about the river.
Some suggestions included colored lights to warn fishermen of rising waters, a dedicated radio channel and rescue throw rings on the shore. Opinions were mixed on getting fishermen in the water to wear personal flotation devices. George Magaro said it just wasn't realistic to expect every fisherman to wear one.
"What are you going to do in inclement weather? Guys have all these heavy winter clothes on - now they have to put a PFD on, said Magaro. Now it's raining - where will the PFD be? It's going to be under their raincoat. So if they do inflate it - it's not going to help."
Michael Carpenter, who was nearly swept away on September 28th with his son, attended Wednesday night TMs meeting. Carpenter he was encouraged by the exchange of ideas.
"I did feel as though there were people trying to make it better, said Carpenter.
Agencies at the meeting will look over the ideas and there will be another meeting in a month to talk about the best options.


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Category: presidential baby names
By Linda Rosenkrantz
In case you don't think the middle name choice is an important one, just take a look at the startling number of celebrities who have opted for using theirs in lieu of the first name on their birth certificates! Some have dropped a ho-hum common in favor of a more dramatic middle, others, to avoid confusion, have shed a name shared with their parent.
To begin with, there have been five US Presidents who have made the first-middle name switch:
Hiram Ulysses S. Grant—At 17, when entering West Point, his name was mistakenly written as Ulysses S. Grant and he apparently was happy to lose the HUG initials. The S was for his mother's maiden name, Simpson.
Like millions of Americans, I was riveted by the Ken Burns documentary on the Roosevelts that aired this month on PBS. (I didn't manage to watch all of 14 hours, but I hope to catch up eventually.)
I adore the first names in the Roosevelt family tree (Alice, Anna, Edith, Eleanor, Elliot, Ethel and Theodore are probably my favorites). But the documentary also got me thinking about Roosevelt itself, which the family's charisma helped turn into a surprisingly common baby name.
In 1905, when Teddy Roosevelt was beginning his second term as president, his surname became the 91st most popular baby name in America. At the time, Roosevelt ranked higher than Stephen, Jacob, Alexander, Patrick or Philip.
Looking at names that were popular in the early days of the U.S. gives us a chance to reflect on how much we have changed and evolved over the last two centuries. We are clearly more multicultural as a society in terms of how many different countries, languages, ethnicities and cultural traditions we draw from in choosing names for our children.
Most of the common names in the early nineteenth century in this country came from the British tradition, and in fact, the lists of popular names would be almost identical for England and America. And yet names were chosen from some of the same sources as today: family histories, celebrities, religious traditions and popular entertainment. The lack of variety or originality of the name lists from this period belies the fact that names were chosen to denote respectability rather than the individuality valued today.


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One of the worst things you can do when you start your new job is to make your supervisor look bad for hiring you. After all, your boss is key to your current on-the-job satisfaction and to your future success in the organization — and perhaps even beyond. If there ever were a relationship for you to invest in, this is it. So here are five ways to get off to a great start with your new supervisor. Your efforts now will lay the groundwork for a productive working relationship over the long haul.
Watch your new boss and learn
"The No. 1 thing is to observe the company culture and your supervisor closely during your first few weeks," says Terese Corey Blanck, principal of College to Career, a career-consulting firm near Minneapolis. "Keep your opinions to yourself until you understand the company culture well."
Even something as simple as asking questions will make a difference in how your boss perceives you. "It's always better to clarify than to charge off and go completely in the wrong direction," Corey Blanck says.
Communicate the way the boss wants you to
Some bosses are very hands-on, keeping close tabs on you throughout your workday. Others may talk to you once a week or less often and send you on your way to do your job.
Whatever your supervisor's style, typically it's up to you to establish and maintain the lines of communication between the two of you. Using either e-mail or the occasional office visit, keep your boss informed:
• What are you working on?
• What have you finished, and what are the results?
• What can you help your supervisor with?
Look and act professional
Allison Hemming, author of Work It! How to Get Ahead, Save Your A--, and Land a Job in Any Economy and founder of The Hired Guns, a Manhattan-based interim workforce agency, talks about a candidate she recently placed with a major investment bank.
"We got a call from her manager, saying that she was doing a terrific job, but that she sometimes dressed inappropriately," says Hemming. "The manager asked me to have a chat with the person, because they really liked her and didn't want her attire to impact her ability to get promoted."
The new hire was a bit shocked, but she made the necessary changes to her wardrobe, Hemming says.
Demonstrate initiative
Any new employee can sit around. Be proactive, so your supervisor doesn't constantly have to hold your hand.
"Take initiative to get something done when you see it needs getting done," says Corey Blanck. "It can be something as simple as taking a stack of files and going through them before you're asked — anything to show that you're not beneath the small tasks."
"Come in early and stay late," says Stephen Viscusi, author of On the Job: How to Make It in the Real World of Work and a frequent workplace contributor on ABC's Good Morning America. "You should be busy whenever you're starting a new job, learning the ropes, but even when you're not, perfect the art of looking busy."
Do great work
This might seem like painfully obvious advice for developing a solid relationship with your new boss, but it bears repeating. "Make your boss look good by, guess what — just plain working hard," says Viscusi. "It's old-fashioned, but it really works."


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NEIL LENNON has revealed that 17-year-old Liam Henderson is already being likened to Scotland skipper Darren Fletcher.
And after watching the rising star stroll through his first start for the club in the 3-0 win over Kilmarnock on Friday, the Celtic boss understands why comparisons are being made with the Manchester United man.
But while Lennon believes the young midfielder is now showing the way to all the other aspiring kids at the club, he is confident Henderson will keep his talented feet very much on the ground.
The Parkhead boss is delighted with the colt's progress and attitude and said: "Liam has set a good benchmark for the rest of the kids now. And there are others - before Liam, Darnell Fisher has already come in and has done very well.
"Darnell has been pretty steady for us in the games he has played this season. But we think that Liam is cultured.
"Someone said he looked a bit like Darren Fletcher on Friday, and I can see the comparisons.
"It is obviously very, very early for that. But for a starting debut made by a kid of that age, it is fantastic for him.
"Scott Brown, Stefan Johansen and Adam Matthews helped him through the game, which was important."
Lennon showed within days of taking charge of the Hoops in 2010 that he believes if you are good enough, you are old enough, with teenager James Forrest.
And while the club will continue to attempt to buy as high a quality as they can afford, the manager wants to keep the flow from the development squad going.
"We know we have a few players bubbling under who may come into the first team," said Lennon.
"But Liam has been at the forefront of things for the majority of the season, in terms of the development squad players.
"It's difficult at times at a big club to make the breakthrough. But you saw at Kilmarnock on Friday how confident Liam is on the ball.
"He is not an arrogant boy. He is, however, quietly confident and he has a great work ethic. We think he can play a bit, and he showed all of that at Rugby Park."
Lennon first gave Henderson his chance as a sub in the rout of Motherwell at Fir Park in November, and added: "Liam just grew into the game at Kilmarnock, and he was a real bonus for us.
"He'll get a lot of confidence from that. We didn't feel it would faze him - and it didn't - because he's been training with us for a little while now.
"We've got high hopes for him, and he's still growing. It's great to see one of the academy boys coming through and playing like that."
Henderson is now looking to add more appearances before the season ends, but accepts he is on a steep learning curve.
The teenager said: "The other midfielders were always talking to me. They are top-level internationalists, and all you can do is learn from them.
"It's a big step up in the pace of the game from the Under-20s, but I felt I became more confident with my passes as the game went on."


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|Home | About | Journals | Submit | Contact Us | Français
Rapidly developing sequencing methods and analytical techniques are enhancing our ability to understand the human microbiome, and, indeed, how we define the microbiome and its constituents. In this review we highlight recent research that expands our ability to understand the human microbiome on different spatial and temporal scales, including daily timeseries datasets spanning months. Furthermore, we discuss emerging concepts related to defining operational taxonomic units, diversity indices, core versus transient microbiomes and the possibility of enterotypes. Additional advances in sequencing technology and in our understanding of the microbiome will provide exciting prospects for exploiting the microbiota for personalized medicine.
The human microbiota consists of the 10-100 trillion symbiotic microbial cells harbored by each person, primarily bacteria in the gut; the human microbiome consists of the genes these cells harbor[1]. Microbiome projects worldwide have been launched with the goal of understanding the roles that these symbionts play and their impacts on human health[2, 3]. Just as the question, "what is it to be human?", has troubled humans from the beginning of recorded history, the question, "what is the human microbiome?" has troubled researchers since the term was coined by Joshua Lederberg in 2001 [4]. Specifying the definition of the human microbiome has been complicated by confusion about terminology: for example, "microbiota" (the microbial taxa associated with humans) and "microbiome" (the catalog of these microbes and their genes) are often used interchangeably. In addition, the term "metagenomics" originally referred to shotgun characterization of total DNA, although now it is increasingly being applied to studies of marker genes such as the 16S rRNA gene. More fundamentally, however, new findings are leading us to question the concepts that are central to establishing the definition of the human microbiome, such as the stability of an individual's microbiome, the definition of the OTUs (Operational Taxonomic Units) that make up the microbiota, and whether a person has one microbiome or many. In this review, we cover progress towards defining the human microbiome in these different respects.
Studies of the diversity of the human microbiome started with Antonie van Leewenhoek, who, as early as the 1680s, had compared his oral and fecal microbiota. He noted the striking differences in microbes between these two habitats and also between samples from individuals in states of health and disease in both of these sites [5, 6].Thus, studies of the profound differences in microbes at different body sites, and between health and disease, are as old as microbiology itself. What is new today is not the ability to observe these obvious differences, but rather the ability to use powerful molecular techniques to gain insight into why these differences exist, and to understand how we can affect transformations from one state to another.
Culture-independent methods for characterizing the microbiota, together with a molecular phylogenetic approach to organizing life's diversity, provided a fundamental breakthrough in allowing researchers to compare microbial communities across environments within a unified phylogenetic context (reviewed in [7]). Although host-associated microbes are presumably acquired from the environment, the composition of the mammalian microbiota, especially in the gut, is surprisingly different from free-living microbial communities [8]. In fact, an analysis of bacterial diversity from free-living communities in terrestrial, marine, and freshwater environments as well as communities associated with animals suggests that the vertebrate gut is an extreme [8]. In contrast, bacterial communities from environments typically considered extreme, such as acidic hot springs and hydrothermal vents, are similar to communities in many other environments[9]. This suggests that coevolution between vertebrates and their microbial consortia over hundreds of millions of years has selected for a specialized community of microbes that thrive in the gut's warm, eutrophic, and stable environment[8]. In the human gut and across human-associated habitats, bacteria comprise the bulk of the biomass and diversity, though archaea, eukaryotes, and viruses are also present in smaller numbers and should not be neglected[10, 11].
Interestingly, estimates of the human gene catalog and the diversity of the human genome pale in comparison to estimates of the diversity of the microbiome. For example, the Meta-HIT consortium reported a gene catalog of 3.3 million non-redundant genes in the human gut microbiome alone[3], as compared to the ~22,000 genes present in the entire human genome[12]. Similarly, the diversity among the microbiome of individuals is immense compared to genomic variation: individual humans are about 99.9% identical to one another in terms of their host genome[13], but can be 80-90% different from one another in terms of the microbiome of their hand[14] or gut[15]. These findings suggest that employing the variation contained within the microbiome will be much more fruitful in personalized medicine, the use of an individual patient's genetic data to inform healthcare decisions, than approaches that target the relatively constant host genome.
Many fundamental questions about the human microbiome were difficult or impossible to address until recently. Some questions, such as the perennially popular "how many species live in a given body site?", are still hard to answer, due to problems with definitions of bacterial species and with the rate of sequencing error. Other questions, such as "how does the diversity within a person over time compare to the diversity between people?", or "how does the diversity between sites on the same person's body compare to the diversity between different people at the same site?", or "is there a core set of microbial species that we all share?", can now be answered conclusively. In the next section, we discuss some of the tools that have allowed these long-standing questions to be answered.
The drastic reduction in sequencing costs experienced over the past few years has made it possible to identify specific microbial taxa found within the human gut that are difficult or impossible to culture. Researchers are now able to generate millions of sequences per sample in order to assess differences in microbial communities between body sites and individuals. Our increased sequencing power has required the development of equally powerful computational tools to handle the burgeoning amount of sequence data produced by modern technologies[16]. There are several pipelines for analysis of microbial microbial community data such as mothur[17], w.A.T.E.R.S[18], the RDP pyroseqeuncing tools[19], and QIIME (pronounced "chime")[20]. QIIME is a free, open-source platform for the analysis of high-throughput sequencing data that enables users to import raw sequence data and readily produce measures of inter- and intra-sample diversity. Consistency in the identification of operational taxonomic units (OTUs) and establishing agreed-upon measures of diversity within and between samples are crucial for the comparison of results across studies, although the concept of OTU is increasingly problematic as sequence data accumulate and explicitly phylogenetic approaches gain in popularity.
Beta diversity refers to the measurement of the degree of difference in community membership or structure between two samples. A recent review of taxon-based measurements of beta diversity found that some metrics, including Canberra and Gower distances, have increased power for discriminating clusters, while other metrics, such as chi-squared and Pearson correlation distances, are more appropriate for elucidating the effects of environmental gradients on communities[21]. A robust method for comparing the differences between microbial communities is UniFrac, which measures the proportion of shared branch lengths on a phylogenetic tree between samples[22]. Highly similar microbial communities result in UniFrac scores near 0, while two completely independent communities that do not share any branch length (i.e. they have a different evolutionary history) would result in a UniFrac score of 1. Principal coordinates analysis (PCoA) can then visualize the Unifrac distances between samples in two-dimensional or three-dimensional space, allowing for the clustering of similar communities or separation of distinct communities to be easily distinguished visually.
UniFrac as a measure of beta diversity, coupled to PCoA, has the ability to distinguish differences between communities utilizing as little as 10 sequences per sample[23]. It is important to recognize that increased sequencing depth is not always necessary to recover biologically meaningful results when those results are obvious. Thus, by choosing diversity measurements that are appropriate for a study design, researchers utilizing modern sequencing methods are able to characterize differences between samples at relatively low sequence coverage. This enables researchers to assess fine-grained spatial and temporal patterns by characterizing hundreds to thousands of samples, such as timeseries across multiple patients or environments. The functionality of UniFrac, as well as a multitude of diversity measurements are available in QIIME and can be readily compared.
In general, pipelines for analyzing 16S rRNA and shotgun metagenomic data have separate workflows. Some initial steps, such as demultiplexing (removing barcodes from and separating pooled samples) and quality filtering, are common to both pipelines. However, for 16S rRNA data, sequences must be grouped into OTUs, chimeric sequences generated by incomplete template extension must be removed, and phylogenetic trees must be constructed. In contrast, in the metagenomic pipeline, sequences must be assigned to functions as well as to taxonomy (either as whole reads or after assembly). Once taxon or gene function tables are constructed, the pipelines begin to converge, at least conceptually: the interest is then in 1) the composition of each sample, 2) finding the taxa or functions that discriminate among groups of samples (e.g. according to clinical parameters), and 3) in asking whether the samples cluster according to any measured clinical states (or according to time). One exciting emerging direction is comparing metagenomic and 16S rRNA clustering directly using a technique called Procrustes analysis that allows the PCoA plots to be combined[24]. Another powerful tool is the use of machine learning and statistical techniques to build predictive models of taxa[25] or functions[26] that discriminate between groups of samples.
A unique advantage of QIIME relative to other pipelines is its ability to exploit "sample metadata", e.g. clinical information about subjects, to produce visualizations that make the main patterns in the data immediately apparent. Of particular interest, QIIME supports the MIMARKS (Minimum Information about a MARKer Sequence) standard[27] developed by the Genomic Standards Consortium[28], which is increasingly popular with other tools for microbial and community analysis such as MG-RAST[29], and has been adopted by the INSDC (International Nucleotide Sequence Database Consortium, which includes GenBank, EBI, and DDBJ) as the standard for metadata.
With these tools in hand, basic patterns of similarities and differences in the microbiota are now routine. The key challenge now is to extend analyses to include longitudinal studies and to understand the role of specific host and environmental factors in the development and maintenance of the microbiome.
The gastrointestinal (GI) tract of a human infant provides a brand new environment for microbial colonization[30]. Indeed, the microbiota that an infant begins to acquire depends strongly on mode of delivery[31]. Twenty minutes after birth, the microbiota of vaginally delivered infants resembles the microbiota of their mother's vagina, while infants delivered via Cesarean section harbor microbial communities typically found on human skin[32]. The acquisition of microbiota continues over the first few years of life, as an infant's GI tract microbiome begins to resemble that of an adult as early as 1 year of life[33]. In one case-study following an infant's microbiota over the first 2.5 years of life, phylogenetic diversity increases significantly and linearly with time[34]. Additionally, significant changes in gut microbiota composition were apparent at five time points; starting a diet of breast milk, development of fever at day 92, introduction of rice cereal at day 134, introduction of formula and table foods at day 161, and antibiotic treatment and adult diet at day 371[34]. Interestingly, each dietary change was accompanied by changes in gut microbiota and the enrichment of corresponding genes. For example, as the infant began to receive a full adult diet, genes in the microbiome associated with vitamin biosynthesis and polysaccharide digestion became enriched[34].
The interaction between the human microbiota and the environment is dynamic, with human microbes flowing freely onto the surfaces we interact with everyday. Fierer et al. showed that human fingertips can transfer signature communities of microbes onto keyboards and these communities strongly differentiate individuals [35]. PCoA plots showed that it was possible to determine which fingers were typing on which keys, and which individuals were using which keyboards: it was even possible to link a person's hand to the computer mouse they use with up to 95% accuracy when compared to a database of other hands[35]. Overall, this study showed that microbial communities are constantly being transferred between surfaces, and that a dynamic interaction exists between environmental microbiota and different human body sites.
Another interesting question that we are just beginning to answer is how stable the microbiome within an individual is over time. By defining what constitutes normal temporal variation in an individual over time, we will be better able to quantify and understand changes in microbial communities that result from dietary and pharmaceutical interventions. In the longest timeseries study to date, Caporaso et al. sampled two individual's microbial communities in the gut, oral cavity, and left and right palms over 396 time points spanning 15 months[36]. Communities at different body sites were readily distinguishable from one another using 3-D PCoA plots over a one year time span, even though the community structure within a given site was highly variable[36]. The level of diversity is also different between body sites, with the mouth and gut harboring the most diverse communities[37]. Taken together, these studies show that an individual's microbiota represents a highly variable and compartmentalized ecosystem.
Overall, it has yet to be conclusively proven that individuals, or even body sites, harbor a "core" set of specific bacterial taxa. For example, the Meta-HIT consortium defined a "core" set of lineages as those that were present in half of the subjects studied, although essentially no genes were present in all subjects studied[3]. Of course, it is important to recognize that sampling depth may be critical for distinguishing taxa that are absent from those that are merely very rare; the dynamic range of microbial abundance is also quite large, and even within the Meta-HIT "core" genes, 2000-fold ranges of abundance were not uncommon. Proving that a taxon is completely absent in the gut is not possible with these types of studies, so core calculations should always carry with them a caveat about sequencing depth. Another factor to consider when defining diversity and a core is that methodological artifacts can greatly increase the apparent numbers of OTUs in a sample (and hence reduce the apparent fraction that is shared). Both sequencing error[38, 39] and issues related to alignment, especially multiple sequence alignment[40-43], can inflate the number of OTUs immensely. It is important to ensure that the same methodological procedures were used when performing estimates of the core in terms of the fraction of individuals the core must be represented in, the minimum abundance, and the procedure for deciding which sequences count as "the same". Finally, there is a key question about whether variation around a core is structured so that humans harbor only a few general types of microbiota profiles in a given body site: this is well established for the vagina[44] but more controversial in the gut[45]. In general, extreme caution must be applied when performing clustering procedures, as many will break up continuous variation into clusters where none exist[21]. Robust model selection procedures that incorporate the possibility that only continuous variation, not discrete clusters, exist remain to be developed within the context of microbial community analysis.
There is increasing evidence that individuals actually share a "core microbiome" rather than "core microbiota". In a study of monozygotic and dizygotic twin pairs concordant for obesity or leanness, a subset of identifiable microbial genes, but not species, were shared between all individuals[15]. Remarkably, vastly different sets of microbial species yielded very similar functional KEGG pathways. However, deviations from this core microbiome were apparent in obese subjects, suggesting that it will be important to utilize metagenomic data in addition to determining microbial community composition with 16S marker gene studies when assessing differences between disease states. Understanding whether this principle holds true for other body sites will be fascinating; cross-biome metagenomic comparisons have been exceedingly rare to date[46, 47].
The evidence is mounting for the inextricable link between a host's microbiota, digestion, and metabolism. In an analysis of humans and 59 additional mammalian species, 16S rRNA sequences clustered together carnivores, omnivores, and herbivores in principal coordinate spacing, showing that community structures differ depending on diets[48]. Dietary changes in mice can also lead to significant changes in bacterial metabolism, especially small chain fatty acids and amino acids, in as little as one week[49], and can lead to large changes after only one day[50]. Importantly, the genetic diversity found within our gut microbiota allows us to digest compounds via metabolic pathways not explicitly coded for in the mammalian genome, greatly increasing our ability to extract energy from our diverse diets[51, 52].
Gut microbiota also seem to play an important role in obesity. Germ-free mice that receive a transplant of gut microbiota from conventional mice have an increase in adiposity without increasing food intake due to increased energy extraction from the diet and increased energy deposition into host adipocytes[53]. The two major microbial divisions, Firmicutes and Bacteriodetes, show different abundances depending on phenotype. Decreased Bacteriodetes and increased Firmicutes have been found in genetically obese mice (ob/ob) when compared to their lean counterparts[54], and the obesity phenotype can even be transferred to a germ-free but genetically wild-type mouse by way of the microbiota, and the phenotype is due to energy balance: bomb calorimetry of the fecal pellets reveal that the ob/ob mice extract more energy from their diet, and leave less behind in the feces[51]. Fascinatingly, the same effects hold true for another mouse model, the TLR5 knockout mice, which also become obese in some mouse facilities (but develop colitis in others, presumably due to differences in the background microbiota). The TLR5 knockout mice also produce a transmissible obesity phenotype, but no difference in the efficiency of energy harvest is involved. Instead, the altered microbiota somehow makes the mice hungrier, and their microbe-induced obesity can be cured by restricting the amount of food in their cages to that consumed by wild-type mice, as well as by antibiotics[55]. The correlation between microbes and obesity is perhaps best illustrated through weight loss. As different groups of human subjects were placed on either a fat-restricted or carbohydrate-restricted diet, their abundance of Bacteriodetes increased as their body weight decreased, transitioning from the signature 'obese' microbial community to a 'lean' community[56]. Thus, the modulation of a patient's microbiota might be a therapeutic option for promoting weight loss in obese patients or promoting weight gain in underweight children.
Surprisingly, the microbes that we ingest with our food might be providing our individual microbiome with new genes to digest new foods. Hehemann et al. found that a new class of glycoside hydrolases used to digest porphyran, a polysaccharide common in red algae, was also found in human stool samples as a gene in Bacteriodes plebeius. A closer examination of the stool metadata revealed that the stool samples containing the porphyran-digesting gene were only present in Japanese individuals; the gene was not found in the gut microbiome of the individuals of the United States. Why would a marine gene be found in human gut? The authors concluded that the seaweed common to the Japanese, but not American, diet contained the microorganism which transferred the genes to gut microbiome[57]. Thus, microbes have the ability to greatly increase the number of metabolic tools of the human gut, allowing us to digest an array of substrates.
Given the relative stability of the human gut microbiota, one key question is whether it is sufficiently plastic to allow well-defined interventions to improve health. As described above, the gut microbiota is fairly stable over time once established, at least compared to the differences between individuals. However, a number of studies demonstrate that external forces can alter the community of microbes located in the GI tract and antibiotics are an important example.
Antibiotics are mainly used to combat pathogenic bacterial species that reside within or have invaded a host, however the current generation of antibiotics are broad spectrum and target broad swaths of the normal microbiota as well. Thus, antibiotics significantly affect the host's innate gut microbiota. Three to four days after treatment with the broad-spectrum antibiotic ciprofloxacin the gut microbiota experience a decrease in taxonomic richness, diversity, and evenness[58, 59]. The large magnitude of changes in the gut microbiota demonstrated significant interpersonal variability. While the gut microbiota began to resemble it's pre-treatment state a week after treatment, differences between individuals were seen with regards to how closely the post-treatment community resembled the pre-treatment community, and some taxa failed to return to the community[59, 60]. Indeed, the reestablishment of some species can be affected for up to four years following antibiotic treatment[61]. Yet the overall recovery of the gut microbiota following antibiotic treatments suggests that there are factors within the community, biotic or abiotic, than promote community resilience, although these have yet to be elucidated.
Other antibiotics also tend to produce results that differ substantially between subjects[62, 63] and even body sites[64]. Because larger populations have not yet been studied, in part due to ethical issues with administration of antibiotics to healthy human subjects, the basis for these underlying differences has not yet been elucidated. Understanding the factors that determine the ability of a microbiota to resist and recover from perturbation, as well as understanding the factors that determine its current state, will be key to developing tools to assist in microbiome manipulation. For example, counter-intuitively, in rats the administration of antibiotics prior to cecal transplant actually reduces the chance that new microbes will establish[65].
One fascinating hint that the microbiota may be more plastic than imagined is the recent success of treatment of persistent Clostridum difficile infections via stool transplant, which has been successful in a number of studies[66-72], and in general the depauperate gut community produced during the C. difficile infection is replaced by the donor community[67, 73]. The success of this technique is remarkable, especially considering how little is known about the best community to supply. For example, is it better to receive the fecal community of a close relative or of a cohabiting individual, or perhaps to bank one's own stool before beginning antibiotic treatment so that it can be restored later? Is the same stool good for everyone, or do the vast differences in the microbiota imply that each person's microbes are specifically adapted relative to those they might receive from a donor? As with blood types, are there "universal donors" and "universal recipients"? These and many other questions remain to be answered.
As in every year since the initial sequencing of DNA, this year has resulted in an unprecedented growth in the amount of sequence data collected at an unprecedentedly low cost. Increasingly powerful tools used to extract meaningful patterns from this wealth of data have been developed or updated as well. Emerging technologies such as stool transplantation, 16S rRNA and whole-genome sequencing on the Illumina platform, the ability to transplant human microbial communities into mice with high efficiency even from frozen samples[50], and the creation of personalized culture collections[74] raises the prospect of a future in which therapies for individual humans are piloted in a battery of mice that are subjected to different treatments, and where leave-one-out experiments that reveal the effects of the deletion of individual species[74] or individual genes from within a species[75] allow insight into mechanism. Although the tools we have available are still imperfect (for example, the limited read length of today's high-throughput sequencing technologies limit the ability to detect bacterial species and strains, and analyses of viruses and eukaryotes are still very much an emerging frontier), the prospects for developing a mechanistic understanding of the factors that underlie the plasticity of the microbiome and then for manipulating the microbiome to improve health seem increasingly bright.
Work cited in this review from the author's lab was supported in part by grants from the National Institutes of Health [HG4872 (RK)], the Crohn's and Colitis Foundation of America, and the Howard Hughes Medical Institute [RK].
PubMed Central Canada is a service of the Canadian Institutes of Health Research (CIHR) working in partnership with the National Research Council's national science library in cooperation with the National Center for Biotechnology Information at the U.S. National Library of Medicine(NCBI/NLM). It includes content provided to the PubMed Central International archive by participating publishers.


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Edit Page Last Edit:
|Promotional Class
|Part 3 — Prologue
|Weak is the word for this part healer, part attacker (though much more of a healer). She is a decent healer, but she starts so far behind Laura and Rhys that she is not very easy to get up to speed, but she does experience well-rounded stat increases, so those who are dedicated can create a very nice unit.
Mist is the younger sister of Ike who makes her first appearnce in the cutscene right after part 2 endgame. She is first playable in the prologue of part 3 and is the only character that can use healing magic and a sword. She can marry Boyd if you import an A support between her and Boyd in Path to Radiance and can make Jill switch factions if you import an A support between her and Jill. She is the only character that can use a Holy Crown which allows her to change class to the only Valkery in the game if she's at level 10.
Mist was courted by many young suitors in her time. She gave then nod to none of them, and lived happily alone.
With A support with Boyd:
Mist acted on her feelings for Boyd, marrying him. She cried during the voews. much to Boyd's chagrin.
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text:
Boulder, CO (July 16, 2009) — N_ve Designs Inc a Boulder, Colorado based manufacturer of natural fiber sweaters, accessories and knitwear announced today that Tom Irvine an existing partner and CEO of N_ve has purchased the remaining assets of the company from founder Rhonda Swenson. Subsequent to the transaction, Swenson will be leaving the company to pursue other outside interests. The rest of the management, design, sales and distribution team will remain intact with several new positions created.
"As challenging as the market conditions are for every company right now, N_ve has a great brand, a loyal customer following and an abundance of enthusiasm. It's a wonderful time for us to recapitalize and recast the company for the future." Says Irvine "With our new structure, N_ve has a chance to truly be a recognized global brand."
N_ve Designs is an authorized licensee of the US Ski and Snowboard Association and supports The Breast Cancer Fund as well as Healthlinks Foundation.
Please direct any questions or comments to Jennifer Tille at N_ve Designs, 2885 Wilderness Place, Unit B Boulder Colorado 80301. www.nevedesigns.com.


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What matters most?
Hoping to improve students' academic performance, Congress implemented No Child Left Behind with strict outcomes-focused requirements places on schools.
But maybe that's not what parents really care about.
A new report out of Brigham Young University suggests that parents want their schools treat their children right more than they worry about whether their children's test scores rise, the Salt Lake Tribune reports.
"While achievement is important, what we're trying to produce in schools and what parents want schools to produce is much broader than test score gains," study co-author and BYU associate professor Lars Lefgren told the paper.
Perhaps this is borne out as close to home as Pinellas County, where parents repeatedly have said that having a neighborhood school trumps so many other concerns, including diversity of the student body. That suggests that comfort, rather than the myriad other social issues, comes first.
But should it? Educators and community leaders continually tell us that American kids are lagging behind their peers internationally. Is that a signal that maybe parents don't know best? Or did schools actually do better when they had true local control, with parents playing a key role? Thoughts, anyone?


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|Tracking Information
|First Submitted Date ICMJE
|September 3, 2002
|First Posted Date ICMJE
|September 5, 2002
|Last Update Posted Date
|September 16, 2013
|Start Date ICMJE
|September 2001
|Primary Completion Date
|Not Provided
|Current Primary Outcome Measures ICMJE
|Not Provided
|Original Primary Outcome Measures ICMJE
|Not Provided
|Change History
|Complete list of historical versions of study NCT00044629 on ClinicalTrials.gov Archive Site
|Current Secondary Outcome Measures ICMJE
|Not Provided
|Original Secondary Outcome Measures ICMJE
|Not Provided
|Current Other Outcome Measures ICMJE
|Not Provided
|Original Other Outcome Measures ICMJE
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Combined Behavioral/Pharmacological Therapy for Insomnia
|Official Title ICMJE
|Combined Behavioral/Pharmacological Therapy for Insomnia
|Brief Summary
|This study will determine how sleeping pills can be combined with nondrug treatments to maximize the benefits of therapy for insomnia.
|Detailed Description
Long-term insomnia is a common and significant health problem. Two main treatments, pharmacotherapy and behavioral therapy, have been used to help people with insomnia. Because both treatments have advantages and disadvantages, a combination of these treatments may be a good way to treat insomnia.
During the first 2 weeks of the study, participants keep a sleep log, wear an actigraph (a device that resembles a wristwatch and records activity to help determine when participants are asleep or awake), and complete questionnaires.
Participants are then randomly assigned to receive 6 weeks of behavioral therapy plus zolpidem tartrate (Ambien), behavioral therapy plus placebo, or behavioral therapy alone. During treatment, participants return to the clinic once a week to turn in their sleep logs, download their actigraph, and complete questionnaires.
After 6 weeks, participants enter the post-treatment phase of the study, which lasts 2 weeks and is identical to the 2-week assessment at the beginning of the study.
After the post-treatment phase, participants enter the follow-up period and are contacted at 3 months, 6 months, and 1 year to complete another 2-week assessment with sleep logs, actigraphy, and questionnaires.
|Study Type ICMJE
|Study Phase
|Phase 2
|Study Design ICMJE
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
|Condition ICMJE
|Sleep Initiation and Maintenance Disorders
|Intervention ICMJE
|Study Arms
|Publications *
|Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Enrollment ICMJE
|Estimated Completion Date
|August 2006
|Primary Completion Date
|Not Provided
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria:
|21 Years to 75 Years (Adult, Senior)
|Accepts Healthy Volunteers
|Contacts ICMJE
|Contact information is only displayed when the study is recruiting subjects
|Listed Location Countries ICMJE
|United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
R01MH062119 ( U.S. NIH Grant/Contract )
|Has Data Monitoring Committee
|Not Provided
|U.S. FDA-regulated Product
|Not Provided
|IPD Sharing Statement
|Not Provided
|Responsible Party
|Duke University
|Study Sponsor ICMJE
|Duke University
|Collaborators ICMJE
|National Institute of Mental Health (NIMH)
|Investigators ICMJE
|Not Provided
|PRS Account
|Duke University
|Verification Date
|September 2013
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


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Madonna is Worth a Billion Bucks?
Tue, 02 Apr 2013 12:10:56
Madonna Photos
Madonna Videos
Madonna has joined an elite list of people worth a billion bucks. That's a lot of scratch.
Madge's net worth had already been estimated at around $700 million, but with her MDNA tour and her Hardy Candy gyms, and her Material Girl fashion line and her interests in Vita Coco vitamin water, things ballooned for her financial ledger sheet. Her Truth or Dare perfume was also instantly profitable.
Congrats to Madge on her good and large fortune, although some reports sprung up that her worth is vastly inflated and is not at the billion mark.
What is your favorite Madonna song? Have you sniffed her perfume? Tried her junior's clothing?
—Maggie Pannacione


text:
Great Lakes Regional Pollution Prevention Roundtable
Promoting Pollution Prevention Through Information Exchange
GLRPPR Contacts: Pacific Northwest Pollution Prevention Resource Center (PPRC)
Note: If you are affiliated with Pacific Northwest Pollution Prevention Resource Center (PPRC), click here to request a change in your information. A confirmation e-mail will be sent to firstname.lastname@example.com.
GLRPPR is a member of the Pollution Prevention Resource Exchange, a national network of regional information centers: NEWMOA (Northeast), WRRC (Southeast), GLRPPR (Great Lakes), ZeroWasteNet (Southwest), P2RIC (Plains), Peaks to Prairies (Mountain), WSPPN (Pacific Southwest), PPRC (Northwest).
One East Hazelwood Drive; Champaign, IL; 61820; (800) 407-0261; firstname.lastname@example.com


text:
By Conor Humphries
DUBLIN (Reuters) - Ireland will become the first euro zone country to exit an international bailout in mid-December and may do so without a financing backstop from its European partners, the ruling party announced at a triumphant rally on Saturday.
Prime Minister Enda Kenny told a gathering of his Fine Gael party that "the economic emergency will be over" when the country exits its 85 billion euro bailout on December 15, confirming the official date of the exit for the first time.
"There's still a long way to go. But at last, the era of the bailout will be no more," Kenny said to loud applause.
Earlier, Finance Minister Michael Noonan gave the clearest signal yet the country may exit without the insurance policy of a precautionary credit line and said he expected to comfortably beat EU deficit targets next year.
Refusing to take a precautionary credit line would block Ireland from accessing the European Central Bank's as-yet-unused Outright Monetary Transactions (OMT) programme of government bond purchases.
But it would also reduce the conditions and close monitoring from European officials and bolster the government's claim to have restored the country's economic sovereignty lost by the previous government.
"Two years ago, I addressed the Irish people and said that I wanted to be the taoiseach who would retrieve our economic sovereignty and independence," said Kenny, using the Irish term for prime minister.
"This goal is now within our grasp," he said.
Left-leaning opposition party Sinn Fein criticized Kenny as celebrating prematurely and said he was out of touch by suggesting that the austerity of the past three years was working for Ireland.
"Try telling families at risk of losing their homes that austerity is working," Sinn Fein leader Gerry Adams said in a statement. "Try telling the 415,000 people on the live (unemployment) register or the 300,000 that have emigrated in the last four years."
The coalition government of Fine Gael and the left-leaning Labour Party is due to release a budget next week that will cut the budget deficit by a third and contain a 2.5 billion euro package of spending cuts and tax hikes, less than the 3.1 billion euro package originally planned.
The budget deficit will fall to 4.8 percent next year from 7.3 percent in 2013, well within targets agreed with the EU, Noonan said. The economy will grow 0.2 percent this year before bouncing back to growth of 1.8 percent in 2014, his department said this week.
The finance minister's suggestion that Ireland may pass on a precautionary credit line came a day after EU Economic and Monetary Affairs Commissioner Olli Rehn said Ireland had a "very good chance" of exiting its bailout without one.
The government had said last month it would seek a 10 billion euro ($14 billion) precautionary credit line from the euro zone to insulate it against market shocks.
"IMF countries that exited bailout programmes in the past had a kind of precautionary programme attached ... but we have a very significant backstop because the NTMA (national debt agency) is carrying cash buffers of about 25 billion euros," Noonan said in a speech to the conference.
"The cash buffers have given us the kind of backstop that we need," he said.
The National Treasury Management Agency said last week it would not tap bond markets in the final quarter of the year, a move that may slow Ireland's return to the "regular market access" it would need to access the OMT. ($1 = 0.7373 euros)
(Reporting by Conor Humphries; Editing by Ron Askew and Peter Cooney)


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Lausanne, Switzerland, March 15, 2011 – The 2011 FIVB Volleyball World League schedule has now been updated to include the dates and times of Portugal's matches after their late inclusion to the tournament on March 1.Portugal, who will compete in Pool C alongside Finland, Argentina and Serbia, return to the FIVB's premier annual tournament for the first time since 2006, replacing Egypt who were unable to compete due to the ongoing political uncertainty in the country.
The 2010 European League champions will open with two home matches against Finland on May 28 and 29 before taking on Argentina a week later on June 4 and 5 and then Serbia a further three weeks later on June 25 and 26. All matches will take place in the northern city of Povoa de Varzim at 16.00 local time (15.00 GMT).Portugal, who lost to eventual qualifiers Puerto Rico in the first leg of the 2011 World League qualification tournament, will be taking part in their eighth World League with their best finish coming in 2005 when they finished fifth. It was the only time they have reached the final round, which took place that year in Belgrade, Serbia. On their last World League outing in 2006, they ranked 13th.This year's FIVB Volleyball World League will run from May 27-July 10 with the final round due to take place in Gdansk-Sopot, Poland from July 6-10. For the first time since 2003, a total of eight teams will qualify from the intercontinental round as opposed to six in recent years.


text:
Inn at Pinnacle Mountain
Heart Stopping Views Of Mountains, Heated Indoor pool and Spa, 4 bdrms, 3.5 bath
27 Pinnacle Mountain Road West Paris, ME US 04289
All Seasons Vacation Rental
877-875-7109, 877-875-7109
Payments Accepted:
Credit Card, Checks, or Cash
Atrium with heated indoor pool and spa
Alternately operating as an Inn, this property is available for weekly or long term rentals. This is a 4 season rental property with many amenities. The Inn has 3 Suites with 1 king bed, and 2 queen beds. 4th bedroom has 4 twin beds. All bedrooms have flat screen TVs, Bose Sound Systems, Kerig Coffee Makers, and iPads for guests to use. The king suite boasts a jetted tub and granite sinks, along with gas fireplace and private deck. One queen suite has walk in spa like shower with travertine tile. Mountain views from all rooms.
A heated glass atrium encloses a heated indoor pool and spa with spectacular views. Family room with bar and large screen TV, Living room with large soft leather sofa and dining room table that will open to seat 12.
The kitchen is updated gourmet w/stainless steel appliances, 2 refrigerators, 2 ovens, a six burner propane stove, dishwasher, and 2 sinks. The Breakfast room and dining room have total of 5 tables and chairs that will sit 10 people.
The front porch has panoramic views of the mountains and has seating for all. The outside kitchen includes a sink, propane cook top, 2 grills (one gas, one charcoal), and 2 refrigerators.
Enjoy the sunset in the evening and sitting around the fire pit on the deck. The property has 52 acres and plenty of hiking trails. There is a pond with a dock so you can fish.


text:
States legalizing pot vs a SD shoot scenario
View Single Post
December 18, 2012, 10:01 AM
Senior Member
Join Date: September 2, 2011
Posts: 582
then say some years later they get hurt real bad or get MS or something and their Dr. prescribes medical MJ and they use it then? No concurrent use of guns and mj, they still have the guns, but may never shoot them again. Any lawyers on the forum care to comment?
My comment is you sound like you're trying to rationalize smoking dope and carrying concealed.
Re your question, the 4473 questions are present tense. "Are you buying.." etc. What, years later you want to go back to the dealer's store and say, "I've got to change one of my answers. I recently started smoking dope."
Seriously, in a self-defense scenario things get chaotic and screwed up in a hurry. Maybe the shooter acted in self-defense. Maybe the DA isn't going to file charges. But maybe the perp's family knows the shooter smokes dope and decides to file a suit. It all comes down to who has the best lawyer.
It's not worth the risk. People say alcohol is so much worse than dope. I don't know one way or the other. But my understanding is the human body metabolizes alcohol much faster than dope. Pot stays in the system for what, a month? If I were on a jury and the defendant had dope in his system and maybe the case was not absolutely clear cut, etc.
"I say, boy, I say, you're doing a lot of choppin', but no chips are flyin'."
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All Nippon Airways Co. is targeting overseas customers as competition in the domestic market intensifies, the airline's president, Shinichiro Ito, said Thursday.
At a news conference at the Foreign Correspondents' Club of Japan, Ito said the arrival of its first Boeing 787 Dreamliner will help ANA become Asia's No. 1 carrier. ANA, which in 2004 became the first airline to order the Dreamliner from Boeing Co., last month became the first customer to receive the state-of-the-art aircraft, whose delivery was delayed by more than three years.
ANA's recent establishment of two low-cost carriers, Peach Aviation Ltd. and AirAsia Japan Co., is also part of its efforts to land foreign customers, especially in Asia, a market that is considered to have rich potential, Ito said.
ANA is also recovering from the huge blow the March 11 disasters and the Fukushima nuclear crisis dealt to the nation's travel industry, Ito said.
When asked for his opinion of the government's Visit Japan campaign aimed at attracting more foreign tourists to the country, Ito said the promotion has not been effective.
"I think the government only recently started to focus on tourism. I believe (the government) lacks the experience necessary to promote Japan's appeal (overseas)," he said. "We must work together to think of effective ways (to promote the country). As one of Japan's airlines, I think we must play our part in such efforts."
Ito's news conference came as ANA is preparing for its maiden Boeing 787 Dreamliner flight on Oct. 26 between Tokyo's Haneda airport and Hong Kong. ANA will become the first carrier to fly Boeing's new fuel-efficient aircraft.
Ito said ANA covered Boeing's delay in delivering the Dreamliner partly by extending the life of aircraft that were due to be retired. The airline is in the final stages of compensation negotiations with Boeing, but Ito declined to disclose any figures.
Despite the delay, Ito said the Dreamliner was well worth the wait and boasted of the comfort he experienced onboard the plane in September, when the new aircraft finally flew from Seattle to Tokyo.
The Boeing 787 is 20 percent more fuel efficient than standard aircraft, making it ideal for long-haul flights, Ito said. "It will play a huge role in our global strategy. We see big potential in expanding our services" to other routes that are unsuitable for smaller aircraft, he said.
ANA will from Nov. 1 start using the new aircraft commercially on routes from Haneda to Okayama and Hiroshima prefectures. The airline plans to start using the Dreamliner for long-haul flights in January, on its Tokyo to Frankfurt route. ANA is expected to receive a total of 55 of the aircraft by the end of fiscal 2017.


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Support BCAPA
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Education in the performing arts teaches confidence, discipline and creative problem-solving skills while developing a vehicle for expression of emotion and spirit. Each semester, students receive the best in performing arts education offered in south central Kansas at the Bethel College Academy of Performing Arts.
Our programs in traditional music, Suzuki strings and performance dance engage students in creative activities resulting in entertaining and imaginative performances for the community. Our organization continues to develop new programs and events to meet the needs of our changing community.
We Need Your Support
Because we are a nonprofit organization, our ability to continually provide excellent experiences in the arts depends on your donations. Your support enables us to supply students with learning materials; brings master teachers to hold workshops; ensures our facility has the necessities for a comfortable learning environment; and provides us with the essential funds needed to produce music recitals and dance concerts, giving our students the chance to realize dreams.
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- A gift of $500 or above specified for an event or recital will result in the event being named after the donor or a named loved one and free admission to BCAPAevents.
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To give to BCAPA, please fill out the Cornerstone form and send to the Bethel College Academy of Performing Arts, Attention: Danika Bielek, 123 East Broadway, Newton, KS 67114
Sponsor a Scholarship
Help foster the growth of the next responsible and creative members of the community by laying the foundation for education. BCAPA believes that no student should be denied an education in the arts due to a lack of funds. Please consider offering support for a scholarship to a deserving student in need.
- Scholarship recipients are chosen by a committee of faculty, members of the board and the director of BCAPA.
- The primary focus of our scholarships is financial need.
- A scholarship gift of $300 and above can be established as a scholarship in the name of the donor, loved one or beloved teacher or performer.
To sponsor a student, please fill out the Foundation form and send to the Bethel College Academy of Performing Arts, Attention: Danika Bielek, 123 East Broadway, Newton, KS 67114


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Setting extension-specific variables
Extension-specific variables are stored in separate sections of the configuration
file. For example, all the variables related to the MySQL extension should be in
the [MySQL] section of the php.ini file.
If you're going to use PHP's mail() function, there are three variables you may
need to set. The SMTP and sendmail_from variables (on Windows) or the sendmail_
path variable (on UNIX) are used when sending e-mail messages through PHP's mail()
function. On Windows, these variables set the SMTP server to be used and the
From: address to display in e-mail messages; on UNIX, the sendmail_path variable
sets the path of the MTA (mail transfer agent) for mail delivery:
SMTP = myserver.localnet.com
sendmail_from = firstname.lastname@example.com
sendmail_path = /usr/sbin/sendmail


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Suppliers for the Week: 08/15/2011
August 15, 2011
Venstar® (Chatsworth, Calif.) announced that it has expanded New York state distribution of its commercial and residential thermostat HVAC control products by adding two new distributors. DBM Control Distributors Inc. (Buffalo, N.Y.) will cover the upstate New York region, and DBM Controls (Elmira, N.Y.) will cover the Finger Lakes region of central New York state.
Publication date: 08/15/2011
Publication date: 08/15/2011
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NBC's Biggest Loser makes a stop in Toledo
Thu, 15 Sep 2011 16:41:18 GMT —
Patrick House said at 425 pounds, he was only 27 years old, but in the body of a 60 year old man. He had to make a change and he was lucky enough to be selected as one of NBC's Biggest Loser contestants for season 10.
"I never knew how I felt at 400 pounds until I started waking up at a healthy weight and I realized how great I felt. I look back and I was waking up in the morning with my back hurting, knees hurting, even before I get the day going," House said. "Now I realize my quality of life is next to nothing. I was waking up sore and tired and going to bed sore and tired. Now, I'm at a healthy weight, I'm waking up, I'm exercising and still feeling great."
House told the producers that he was going to do whatever it took to be the biggest loser--and he did. H e was sequestered to the ranch with the other contestants and went through grueling training sessions with B iggest L oser trainers, B ob Harper and Jillian Michaels. After six months, he lost 202 pounds and won. In his recent visit to Toledo, he says it takes dedication.
" You're doing what you can. You are trying. You're trying to change," He continues, " The people that aren't trying to change are the people that are still obese and still hitting the buffets and still hitting the fast food lines. Those are the people that aren't trying. You're in the gym, you're giving it what you can and you should be patted on the back for that."
You can sign up for Toledo's Biggest Loser. Be a part of the weigh ins and the tough workouts all season long! Just click here.


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The Belgrave Harrier produced a consistent set of four 17-metre-plus jumps, including a second-round effort of 17.24m that was enough to win in appalling weather conditions.
World indoor champion Will Claye was second with a leap 17.12m while fellow American Christian Taylor, who deprived Idowu of the gold medal at last summer's World Championships, was third with 16.96m.
Mo Farah also got his outdoor track season off to a superb start in Los Angeles by doubling up in 1500m and 5,000m races on the same evening and achieving world-class victories in both.
The Londoner won the metric-mile race in 3min 34.66sec, which was inside the 'A' Olympic qualifying standard, before winning the 5,000m in 13min 12.87sec - the fifth fastest in the world this year.
Meanwhile, Lawrence Okoye, 20, underlined his rich Olympic potential medal by smashing his own UK discus record with a throw of 68.24 metres in Halle, Germany. It puts him third on this year's world list.
Jo Pavey, who missed out on selection for the Olympic marathon, was also celebrating after securing the 5,000m Olympic 'A' qualifying standard with a time of 15min 14.19sec in Manchester last night.


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WINTER PARK — In the last year, Plant senior Brian Baird has nursed a stress fracture in his lower back, nagging shin splints and his coach's move to the Mountain Time Zone.
All of which begs a rhetorical inquiry: What else could fate hang on one kid?
How about a gold medal.
On a windless Saturday in Winter Park, Baird rediscovered his approach steps, his jump and his smile. In one of the most intense pole vault competitions in recent state meet memory, Baird nailed a 15-foot effort to win the boys Class 4A title at Bob Mosher Track at Showalter Field.
"I can't remember feeling a better feeling than this," Baird said.
On a day devoid of humidity, Baird's good feeling was only mildly contagious.
Each highlight — Riverview sophomore Faith Woodard's runnerup finish in the girls high jump, and Chamberlain junior Max del Monte's second-place effort in the boys 1,600 meters — seemingly was offset by a disappointment.
Singularly personifying that bittersweetness was Riverview senior Ashley Favors. Seeded first in the 100 hurdles, Favors clipped the third hurdle, causing a disruption to her stride, and she struggled to an eighth-place finish.
She redeemed herself an hour later with a runner-up effort in the 300 hurdles, recording a personal-best time (43.75 seconds) in an event in which she was seeded eighth.
"I was kind of sad about (the 100), and I kind of just said, 'You know what, whatever happens happens, just go out there and run as best as you can,' " Favors said.
Atonement was far more elusive for Alonso junior Brandon Holloway. For the second consecutive postseason, a false start ended his quest for a 200-meter medal, this time in the preliminaries. He reached the finals in the 100 meters, however, placing seventh in an ultra-elite field.
"It was very disappointing, but I'm still grateful I got to run here," Holloway said. "A lot of people can't even say they're top eight in the state or anything like that, so I'm glad to be running with the top in the nation out here in these races."
Then there was Baird, bedecked in black shin wraps and resilience.
Ten days after failing to clear 14 feet against a considerable crosswind at the Region 2 meet, Baird appeared to easily clear 15 feet and just missed at 15-6. On Saturday, his 15-foot effort was matched by Pinellas Park's Eddie Galan, but Baird prevailed via fewer misses.
"It's just a matter of getting my step right because that's what I was really struggling to find, and I was struggling down near the end of my jumps, at the end of the run," said Baird, who lost his coach when former Panthers state champ Justin Semeyn moved to Colorado.
"I just got it better today than I did any other day."
The top-eight finishers in each event earned medals. Other local girls placers were the Plant girls 4x800 relay (seventh), Wharton's Abby Ritter (eighth in 1,600) and Plant's Caroline Gibson (seventh in 3,200).
Other boys placers: Newsome's 4x800 relay (sixth, in a school-record time), Brandon's Shawn Council (seventh in discus) and Alonso's Franklyn Moseley (fourth in 400).


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Heather Nyberg-Schlotzhauer
Beacon Correspondent
Recently the Fortuna Chamber of Commerce held their monthly mixer at the Riverlodge hosted by Wendt Construction and Hops in Humboldt. Riverlodge provided the venue to promote the new Made in Humboldt Gallery in the gift shop area of the conference center.
"The Made in Humboldt Gallery is dedicated to improving the quality of life for the community of Fortuna," Riverlodge Director Debbie Reynolds said. "The Gallery will provide an accessible venue for visitors and artists from our neighboring communities and encourage tourism."
Chamber and community members were able to stroll through the gallery and see a number of locally made products available for purchase. In addition product business locations were provided so consumers could visit and see the extensive line of products instead of just the sampling provided at the Riverlodge.
"We wanted to create a new point of destination in Fortuna utilizing the potential of the Riverlodge space by improving revenue through expanded consignment sales, lower inventory burden, and a streamlined merchandise program," Reynolds said.
Fortuna has been working towards improving their place in the artistic world and Riverlodge is supporting that effort.
"We wanted to provide a professional and progressive gallery experience that would complement the continued efforts of the City of Fortuna and its support of the arts by becoming a cornerstone for the fine art community of Fortuna," Reynolds said.
The gallery is meant to be a sampling of the local art community and will not carry an extensive inventory, but rather direct visitors to the actual businesses in hopes of increasing foot traffic throughout the professional artists.
For more information on the Made in Humboldt Gallery you can contact Debbie Reynolds at the Riverlodge at 725-7572 or visit the gallery at 1800 Riverwalk Drive in Fortuna.
Photo by Heather Nyberg-Schlotzhauer/Beacon
The Fortuna Chamber of Commerce recently held their monthly mixer at the Riverlodge hosted by Wendt Construction and Hops in Humboldt to promote the new Made in Humboldt Gallery located in the previous gift shop area.