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Founded by Walter H. Annenberg, the Annenberg School for Communication produces research that advances the understanding of public and private communication and produces applied research that advances policymakers' ability to create a media environment for the development of its citizens. Penn's Annenberg School educates doctoral students in the theories, substance and methods of communication research and places them in leading academic and professional positions. Annenberg also provides a first-class liberal arts education to undergraduates, helping them become better consumers and producers of public information, strengthening an understanding of communication and preparing them for private and public sector leadership.
Annenberg School for Communication
Arts & Sciences
The School of Arts and Sciences, the University's intellectual core, houses 26 departments and nearly 500 scholars with honors that include the National Medal of Science, MacArthur Fellowship and Pulitzer and Nobel Prizes. SAS enrolls nearly half of University students and is integral in the education of all undergraduates plus many graduate and professional students, lifelong learners and working professionals. Undergraduate offerings include 54 majors, signature interdisciplinary programs and distinguished dual-degree programs, such as the Huntsman Program in International Studies and Business and Vagelos Program in Life Sciences and Management. Graduate offerings include 33 doctoral and 10 master's programs.
Dental Medicine
Established in 1878, Penn Dental Medicine is among the oldest university-affiliated dental schools in the nation, with a history of forging precedents in education, research and patient care. Academic programs include a DMD program with dual-degree options in education, bioethics, bioengineering and public health; postdoctoral training in eight specialties with an option for a master's in oral biology; and a degree program for foreign-trained dentists. Students log nearly 9,600 service hours annually serving more than 20,000 neighborhood residents. Penn Dental Medicine spans basic and clinical sciences and provides community dental care in teaching clinics and the Penn Dental Faculty Practices.
PennDesign is an inventive place of learning where the fields of architecture, planning, preservation, landscape and fine arts come together. Formerly known as the Graduate School of Fine Arts, the school is committed to design that is creative in nature and transformative in impact. Faculty and students seek to recast the distinction between theory and practice, expand knowledge and invention through research and contribute works of value and beauty. PennDesign offers a number of dual degrees and certificate programs that foster inquiry and experimentation in a collaborative environment.
Founded in 1852 as the School of Mines, Arts and Manufactures, today's School of Engineering and Applied Science is a vibrant part of the University. At Penn Engineering, world-acclaimed faculty, state-of-the-art research laboratories and highly interdisciplinary curricula offer students an unparalleled experience. Innovation and technology drive the program and transform the fundamentals of what future engineers are learning. Penn Engineering students play a critical role in posing and answering the important questions that will improve human health and transform our world.
Graduate School of Education
The Graduate School of Education is one of the nation's premier research education schools, and GSE faculty members are national leaders in the production of educational and social research. The school has long been known for excellence in teacher education and in leadership-preparation programs for educators in K-12 and higher education settings. Penn GSE also excels in the production of scholarship in language and literacy, teacher education, educational policy, higher education, applied psychology, social theory and social research methods. GSE offers innovative degree programs for practicing professionals and provides students with partnership opportunities with local educators.
Law School
Penn Law offers a superior legal education enhanced through cross-disciplinary study opportunities unrivaled among leading law schools. To complement their rigorous legal training, students can take classes to earn certificates or joint degrees at other Penn schools and programs, from Wharton to the Center for Bioethics. The intellectual vitality of Penn Law is defined by the faculty, an outstanding group of scholars in every major legal area. More than 70 percent hold advanced law-related degrees beyond the JD, and more than 50 percent have joint appointments or affiliations with other Penn schools.
The School of Nursing is one of the nation's premier research institutions in nursing. Penn Nursing faculty consistently receive more research funding from the National Institutes of Health than any other private nursing school, and many master's programs are ranked first in the country. Students are offered unparalleled resources and experiences, including a state-of-the-art simulation lab, a nurse-led elder-care practice and classrooms equipped with the latest technologies. Penn Nursing students gain valuable clinical experiences in two of the nation's best medical institutions, the Hospital of the University of Pennsylvania and The Children's Hospital of Philadelphia.
Perelman School of Medicine
As the nation's first medical school, the Perelman School of Medicine, named for Raymond and Ruth Perelman, has a long-standing commitment to education, research and patient care. Today, it consistently ranks among the top medical schools in the country and among the top three in National Institutes of Health grants awarded to medical schools . In addition, the Perelman School of Medicine offers outstanding Ph.D., master's and combined-degree programs. The school's students are among the finest in the nation, receiving training at the University of Pennsylvania Health System, which includes nationally acclaimed hospitals dedicated to high-quality patient care and service.
Social Policy & Practice
As the School of Social Policy & Practice enters its second century, it is one of the nation's leading centers of knowledge development, transfer and application in human services. The theory-based master's programs in social work, social welfare, non-profit leadership and social policy and the clinical doctorate program in social work encourage students to think and work nationally and internationally across disciplines and cultures. This vision is reflected in all aspects of the school's educational and research programs as well as in work on the Penn campus, in the Philadelphia community and in national and international social change efforts.
Veterinary Medicine
Penn Vet is focused on providing the best care to beloved pets, preventing zoonotic diseases in animals and humans, protecting the food supply and discovering treatments for animal illnesses. Since 1884, Penn Vet has recognized that human and veterinary medicine are "one medicine," and close ties with the Perelman School of Medicine have resulted in groundbreaking research. The Philadelphia campus includes the Matthew J. Ryan Veterinary Hospital for small and companion animals, and Kennett Square's New Bolton Center houses the George D. Widener Hospital for Large Animals. Penn Vet also plays an integral role in supporting Pennsylvania agriculture.
The Wharton School
Founded in 1881 as the first collegiate business school, Wharton is recognized globally for intellectual leadership across every major discipline of business education. Wharton delivers the knowledge to take action and advance society through leading programs at every level: undergraduate, MBA, executive MBA and doctoral. The school reaches out annually to 9,000 participants through Executive Education programs. Knowledge@Wharton, the school's online journal in multiple languages, reaches more than 1.7 million global subscribers. Wharton has one of the largest business school alumni networks in the world with more than 88,000 graduates.


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Derek Sanderson caught a glimpse of his book on the table. The main photo on the cover is of him, much younger and in a Boston Bruins jersey, a lit cigarette dangling from his lips, his hands pressed together as if in prayer.
He was smiling then, and he was smiling now.
"You know that picture was a Polaroid?" Sanderson asked.
It was from the cover of the January 1971 issue of Boston magazine. The story "The Beatification of Derek Sanderson," was published after the hard-nosed forward from Niagara Falls, Ont., had established himself not only as one of the most colourful characters in the National Hockey League, but in all of professional sports.
And the photo shoot took hours.
"I gotta have a cigarette," Sanderson remembered pleading with the photographer. "This is the longest I've gone without a butt in a long time."
The photographer relented.
"So I lit up," Sanderson said. "And I said, 'Thank God.' "
The photo is the main image on the cover of Sanderson's book, Crossing the Line: The Outrageous Story Of A Hockey Original, which was published last month.
In the book, Sanderson, 66, talks about the glamorous times that made him a cover boy in the late 1960s and early 1970s, with the stops on late-night television, more time spent in the bars, and the short-lived celebrity supernova he formed when he went into business with then-NFL star Joe Namath. As the title suggests, the book also covers the other side of the line he crossed, opening with Sanderson sleeping on a park bench in New York's Central Park.
A movie of his life is in the works. And before he hits theatres, Sanderson took time out to answer 20 Questions from the National Post, talking about dating Playmates, living the celebrity life and learning how to prepare cocaine for sale on the street:
1. Johnny Carson or Dick Cavett?
"Oh, Johnny Carson. Dick Cavett's an arrogant son of a bitch. Johnny Carson is the most pleasant … he reminds me of an absolute superstar. Just had a ton of class. He didn't need people. He was big."
2. What happened on your lone appearance on The Dick Cavett Show?
"I got there and sat in the seat. And he said to me, 'Ah, you got all your teeth?' And I said, 'Oh, that's an intelligent question, Dick. I thought you were supposed to be cerebral. That's a very naïve hockey question. Of course I don't.' And then he got mad because I kind of put him down. I think I got kicked off. I'm not sure. I didn't do the full 12 minutes. When we first got to break it was, 'get him out of here.' And that was it."
3. Explain what Bachelors III was.
"What it was, in 1968: There were three 'dating bars' in North America; The Candy Store in L.A., The Peppermint Lounge and Bachelors III in New York — where girls could go unattended. Girls never went out without friends, in a pack of three or four. You couldn't be alone. You were considered suspect. I mean, 'Do I offer you money or anything?' You know what I mean? … And they wanted to have fun. They wanted to enjoy life, too."
4. The two best perks of being a partner in Bachelors III with Namath?
"The celebrity recognition status went off the charts. And there's a ton of power when you're an owner. You know, you pick up the tab. That's where I learned to do this — [leans back, points to table with his index finger] — like, 'Yeah, I got this.' Joe called it the power of the pen. And I said, 'Yeah, that's a killer.'"
5. Can you estimate the number of times the word "Playmate" appears in this book?
"Oh, that was my life. And, what you didn't use was 'stewardess.' You have to remember, in those days, there was a beauty contest to be a stewardess. Now they call them flight attendants … So, if I said to you, 'OK, I'll go out, get a girl for you, fix you up, go on a double-date, she's a stew.' You'd say, 'Oh wow.' I wouldn't have to tell you anything else. That's how good-looking they were. They were really attractive. And The Playboy Club … they were the 64 best-looking women in Boston. Oh. Scary. When you see them all together, it's actually overwhelming."
6. What's the smart way to sleep on a damp New York City park bench?
"What? Oh, yeah, yeah. I had this girl; she dumped me; she took the money. I'm freezing. And I had no money, so I couldn't get anywhere. It was raining out, spitting all over the place. I lay down with The New York Times. I'm trying to get something on my arm, and an old-timer comes by and he says, 'Put the paper on the bottom side, too. Stay dry on both sides.' I said, 'There's a way to live here?' He says, 'Yeah.' I says, 'Holy sh–.' And he says, 'If you need money, find a good corner, and you can panhandle, get $100, $150 a day.' "
7. What is the best way to steal a mickey of vodka from a store?
"You gotta go to the front. They're on sale, and they always put 'em like a bookrack. They won't chase you for a pint. They'll chase you for a quart. If they do chase you, you don't need that, because you're not in the best of shape."
8. How does one go from being a late-night television guest star, a professional hockey player and a nightclub owner to a homeless man stealing booze in New York City?
"People can't understand how it can happen to you. I sat in Central Park as a drunk, and I said, 'How did this happen?' And then I said, 'Well, you trusted the wrong people; you made very quick decisions without thinking it through; put yourself in spots you should never put yourself into, and you got swindled. And you've got such a high opinion of yourself, you didn't think it was going to happen.' "
I don't get nervous or scared now, because now I'm honest
9. You list a half-dozen reasons why you started drinking: Does one stand out?
"Yeah, my dad was an alcoholic. I never saw him drunk, but I didn't know he was a maintenance drinker. It was in my family. My grandfather … so if it's in your family, you have a 300% chance of being predisposed to the disease by birth. So you're born an alcoholic."
10. How pervasive do you think alcohol was as medication either for physical or emotional pain in NHL dressing rooms?
[whispers] "Oh, everybody drank."
11. Really?
"Hockey is notoriously full of beer drinkers. And the game is Canadian, and that's, culturally, what you do. I really wanted to play hockey. And my dad said, 'Well, booze will kill you, and it'll get you to do stupid stuff.' So he always wanted me off it — 'Do as I say, not as I do' — and that's what sort of happened."
12. You write you were drinking the night you tried to lose your virginity, as a teenager …
"Oh, yeah. I didn't know whether I was on foot or horseback. I mean, kids today, with such rampant pornography on the Internet? They know everything, how to do things. I remember my first time was a disaster. I said, 'I'll never do this again.' It was horrifying. But that's what I did, when I got nervous or scared, I took a beer."
13. What do you do when you get nervous or scared now?
"I don't get nervous or scared now, because now I'm honest. I just don't lie. I remember that I couldn't remember my lies. It got so bad — I'd tell you something, I told him something, told her something — it was, 'I got to get out of here, or go get drunk.'"
14. And then you got deeper than just booze.
"You know why you do drugs? To drink more. Cocaine only keeps you up so you can drink more. That's all it does."
15. How long did it take you to prepare an eight-ball of cocaine?
"Oh, it isn't hard. You've got the goods there, and you've got the lactose and baby laxative, or flour, or whatever you've got. And you cut one up, you take a look at it, then double that pile — [cuts imaginary lines with hand on table] — then double that pile, then double that pile, then cut it three ways. But when it comes out of Colombia or wherever, when it gets here, you don't get it very pure. It's already been cut … there's nothing that's 100% cocaine."
16. You're a financial advisor now: Lay out a plan for Derek Sanderson circa 1971.
"In 1971, it would have been a very conservative philosophy. Buy big companies that you know will consistently grow, that will have maybe a franchise, like a CVS (drug stores) … You want to put a plan together. You need a plan."
17. The 40th anniversary of the Summit Series just passed. Any mixed emotions, having not been allowed to play?
"No. I'm glad that Harry Sinden had picked me for the team. I think it was foolish and vindictive of [Alan] Eagleson to say anybody in the WHA can't play. It was the talent that was in Canada. It was Canada playing. It wasn't the National Hockey League, it was Canada. Gerry Cheevers certainly would have been one of the goaltenders. At the time, I was afraid of flying, and I wasn't too keen on going to Russia anyway." (laughs)
18. What souvenirs did you keep from your playing days?
"I got the [Stanley Cup] rings. And I got the shirt that I was wearing when I passed the puck to Bobby [Orr], and the stick that I passed the puck to Bobby with. Actually, my dad saved that. Actually took it from the rink. Two Stanley Cup replicas. I had a lot of stuff up at the cottage, but my mom sold that. So whoever bought it got all that stuff."
You get can out of this hole that you've put yourself in
19. What reaction do you think this book might elicit from the reader?
"Well, I want it to elicit information. And I want it to be comfort that you can recover, that you get can out of this hole that you've put yourself in. I remember seeing no hope. Really feeling down, depressed, suicidal — 'How am I going to get out of this?' I remember going 20 minutes, trying to stop booze. A half-hour. I just put a bottle in front of me and watched it. That bottle sitting in front of you has got a lot more patience than you do. Eventually, you say, 'Ah f— it.' The alcoholic's national anthem: 'Ah, f— it.' "
20. Did you ever think, at this point in your life, you'd be siting inside a Toronto office tower, talking about your book, your life, your family, and your successes?
"I don't think I would have stayed sober without my wife and the boys."

subset: commoncrawl


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awesome! Signed up!
Skiing, riding or staying active this winter? Raise money while you are doing what you love! Park City Gold is a four-week virtual ski-snowshoe-run-whatever-a-thon benefiting the Youth Sports Alliance.
There are three events that you can participate in to support the Youth Sports Alliance and your favorite local club – virtually downhill Ski/ride with Shannon Bahrke: www.athlete.com/ysadh or 'choose whatever sport you love' to raise funds for the Youth Sports Alliance Dare to Dream Scholarship fund: www.athlete.com/ysamulti
Join this event for Cross Country Skiing.
• Registration: YSA Beanie
Fundraising: (details in the challenges below)
• YSA Neck Gaiter
• Skullcandy Headphones
• Soul Poles or Jambox
• Goggles or a GoPro
• Entry into a drawing to win a Heli-Ski trip for 2 or First Tracks with Shannon Bahrke!
Most Mileage: (per age group)
• Cross Country Ski Package
Brett moved to Park City when he was age 6 and began his career in YSA's Nordic program! Brett started as a ski jumper, later added cross country skiing, and ultimately competed in the Nordic combined. More about Brett www.teamusa.org/Athletes/CA/Bret... To learn more, click here.
The Mission of The Alliance is to support winter sports activities for youth in Summit and Wasatch counties, promoting good sportsmanship and healthy lifestyles through participation, education and competition.
Learn more at ysapc.org
Invite specific friends:
You are now sponsoring Aimee for $0.00 per kilometer. Kilometers will be totalled and your pledge will be collected on March 23rd.
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6404 Auto Center Dr
Directions Ventura, CA 93003
Kirby auto Group, 3rd generation for 50 years
Exterior Color: Ice Silver
Interior Color: Black
Vin Number: JF1ZCAC11H8603986
Stock: 603986
View this 2017 Subaru BRZ Coupe Limited for sale at Kirby Subaru of Ventura in Ventura, CA
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*In transit means that vehicles have not yet arrived at your dealer. Images shown may not necessarily represent identical vehicles in transit to your dealership. See your dealer for actual price, payments, final accessories, expected delivery date and complete details.


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Video: Hamas chief Meshaal makes historic Gaza visit
7 Dec — The political leader of the Palestinian movement Hamas has set foot in Gaza for the first time. Khaled Meshaal crossed into the strip from Egypt and was welcomed by members of various Palestinian factions. A large rally is to be held on Saturday to welcome him. Fatah, Hamas' political rival, has also been invited to attend the rally, and has indicated that it would do so. Al Jazeera's Nicole Johnston reports from Gaza City.
Meshaal to attend Gaza anniversary rally
Al Jazeera 8 Dec — Thousands of Palestinians are due to turn out for 'victory' rally to commemorate the 25th anniversary of Hamas Movement. After receiving a hero's welcome on his return from decades in exile, Hamas leader Khaled Meshaal will attend a rally in Gaza to mark the 25th anniversary of the founding of Hamas Movement and the start of the first Palestinian uprising, or Intifada, against Israel in December 1987. At least 200,000 Palestinians are expected to attend the outdoor event on Saturday, which is likely to be used by Meshaal to promote Hamas's growing stature in the Arab world and push the case for reconciliation with its secular political rival, Fatah.
Joy at return of Hamas leader tinged by unity regret
GAZA CITY (Reuters) 7 Dec — Policemen kissed him, crowds mobbed him and gunfire rattled out in celebration as Hamas leader Khalid Mashaal made his first ever visit to the Gaza Strip. But the scenes of joy at his arrival in this small splinter of land could not disguise deep-rooted disunity between the Palestinian factions, ensuring its people remain divided both geographically and politically … "Gaza lives forever thanks to its fighters and people," said 44-year-old public sector worker, Abu Mohamed. "Mashaal's visit is a first step. We hope Fatah and Hamas will join hands for the sake of Palestine," he added … Clearly aware of the yearning for reconciliation, Mashaal repeatedly returned to the subject during his many stops around Gaza, home to some 1.7 million mostly impoverished Palestinians … Yellow Fatah flags fluttered alongside the Hamas colors on some streets and a senior figure from the movement was one of the first to greet Mashaal as he entered the enclave.
Mashaal: Today Gaza, tomorrow Jerusalem
GAZA CITY (Ma'an) 6 Dec — Hamas chief Khalid Mashaal made his first visit to the Gaza Strip on Friday, telling crowds he hoped his next visit would be to Jerusalem, Ramallah and a liberated Palestine. After passing through the Egyptian border crossing, Mashaal knelt on the ground to offer a prayer of thanks and was then greeted by dozens of officials from an array of competing factions lined up to meet him in warm December sun … The leader was briefly tearful as he was welcomed by Gaza's Prime Minister Ismail Haniyeh. Mashaal said his visit to Gaza was his "third birth" referring to an assassination attempt by Israeli Mossad agents in 1997 as his previous "re-birth." "I pray to God that my fourth birth will come the day we liberate Palestine," he said, clearly moved by his reception, with uniformed police breaking ranks to try and kiss his hand.
Exiled Hamas leader set for historic Gaza visit
GAZA (Reuters) 6 Dec — Hamas's exiled leader will step onto Palestinian land for the first time in 45 years on Friday for a "victory rally" in the Gaza Strip, displaying his newfound confidence after last month's conflict with Israel. The Islamist group's leader, Khaled Mashaal, who has not visited the Palestinian Territories since leaving the West Bank at age 11, emerged emboldened from the eight day conflict which ended in a truce he negotiated under Egypt's auspices. He has since spoken of reaching out to other Palestinian factions
The rise of Meshaal, Hamas' born again survivor
GAZA, Palestine (AFP) 8 Dec — Long considered a radical, Hamas leader in exile Khaled Meshaal has gradually shifted position to an implicit acceptance of the notion of a Palestinian state alongside Israel. "This is my third birth," he said as his made his first ever visit to Gaza Friday, counting his escape from an Israeli attempt on his life in Jordan in 1997 as his second. Aged 56, imposing but affable, the former physics teacher with salt-and-pepper hair and large dark eyes was born in Silwad, near the West Bank town of Ramallah. It is there that he spent his childhood before going into exile with his family to Kuwait, following the Arab-Israeli war of 1967 when the Jewish state seized the West Bank…
On Sept. 25, 1997, agents of Israel's Mossad secret service disguised as Canadian tourists bungled an attempt to assassinate him on a street in Amman by injecting him with poison. Three of the attackers took refuge at the Israeli Embassy, but two were captured by Jordanian authorities. Meshaal fell into a coma and a furious King Hussein demanded Israel hand over the antidote if it wanted the captured agents to be freed. The episode compelled then Israeli Prime Minister Benjamin Netanyahu – re-elected in 2009 – to release Hamas spiritual leader Sheikh Ahmad Yassin and 19 others from prison. [See the fascinating book Kill Khalid]
Islamic Jihad chief 'reconsiders Gaza visit after Israeli threat'
GAZA CITY (Ma'an) 6 Dec — Israel threatened to assassinate the leader of Islamic Jihad if he enters the Gaza Strip, causing the party to reconsider his upcoming visit, sources said Thursday … Jihad's leadership are in talks with the Egyptian authorities over the matter.
Gaza fishermen after the ceasefire [includes a video]
ISM 6 Dec — On Wednesday 5th December, Gaza fishermen staged a peaceful protest in the port of Gaza City, in order to highlight the Israeli attacks on their livelihoods. They were supported by the local Fishing Union, the Union of Agricultural Work Committees and the Palestinian Centre for Human Rights. Gaza fishermen constantly face Israeli military aggression in Gazan territorial waters — just as farmers attempting to work their land in the buffer zone have been facing on a regular basis since Israel's massive assault on Gaza in late November. Both cases constitute a violation of the fragile ceasefire.
Video: Gaza's armed groups unite against Israel
7 Dec — During the recent fighting between Israel and Palestinian fighters, there was an unprecedented level of co-operation between the dozens of resistance groups in Gaza. The fighters say that for the first time, they are now united in planning attacks against Israel. Al Jazeera's Nicole Johnston reports from Gaza.
Gaza minister of interior frees 80 prisoners
GAZA CITY (Ma'an) 7 Dec — The ministry of interior in the Gaza Strip decided Friday to release 80 prisoners who had served two-thirds of their sentences as a celebratory gesture following Palestine's admission to the UN.
Yemen offers jobs to Gaza graduates
GAZA CITY (Ma'an) 6 Dec — Yemen is offering job opportunities to new graduates in the Gaza Strip, an official at the ministry of education announced Tuesday. Zakaria al-Hour said 27,000 Palestinian university graduates were out of work in Gaza, and the ministry of education has reached out to foreign offices to ease that rate. Yemen, he said, responded and offered its support to Palestinians in Gaza. It is recruiting graduates in the fields of Arabic, Islamic education, English, science, math, computers, chemistry, physics, biology, and information technology.
Malaysia donates $1 million to UNRWA
BETHLEHEM (Ma'an) 6 Dec — Malaysia has donated $1 million to support UNRWA in the Gaza Strip in response to Israel's recent war on the enclave, the UN agency said Thursday. The contribution is in addition to $200,000 donated by Malaysia in November to support the regular services of the agency, which supports Palestinian refugees.
Land, property theft / Threats to Palestinian heritage and culture / Restriction of movement
The Arab villages that were: a new Israeli guidebook
Haaretz 7 Dec by Moshe Gilad — A new volume in Hebrew and Arabic retraces a past that many prefer to forget — A round white dome stands in the middle of the vacation village at Dor Beach, near Caesarea. I've visited this place dozens of times but never noticed the sheikh's tomb on the well-tended lawn. Nor did I remember the large stone building right on the shoreline, a few dozen meters from the water, opposite the bobbing fishing boats. This made me wonder. After all, this beach – also known as Tantura – was among my parents' favorites and as a child we would go there every summer. Still, when I pressed the intercom at the entrance to the village and explained why I'd come, the woman declared: "There are no antique buildings here. You are mistaken." I tried to persuade her that the guidebook I was carrying – an intriguing new volume, in Hebrew and Arabic, called "Omrim Yeshna Eretz" ("Once Upon a Land – a Tour Guide" ) – contradicted what she had said. Maybe she doesn't see the sheikh's tomb either, although she walks past it every day.
The guidebook offers 18 tours in various locales, including Palestinian villages that were evacuated in the late 1940s, most of which were destroyed … Regarding the book, let me say straightaway that its importance goes beyond the mere fact of its publication. It contains consistent, systematic historical documentation, with a clear political opinion, of a past we tend to ignore.
Settlers storm the evacuated Tarsala settlement
PNN — On Friday 7th December, Jewish settlers stormed the evacuated Tarsala settlement outpost to the south of Jenin at dawn under protection of the Israeli occupation forces. Security sources said that dozens of settlers broke into the settlement, performed their religious rituals and chanted anti-Palestinian and anti-Muslim slogans. Tarsala is one of four sites evacuated by the IOF in the West Bank in 2005.
Preserving or looting Palestinian books in Jerusalem / Ofer Aderet
Haaretz 7 Dec — The National Library in Jerusalem houses more than 8,000 volumes in Arabic which once belonged to Palestinians who fled the country or were forced out in 1948. Were these books collected for the purpose of preservation – or looted? … Was gathering them part of an Israeli salvage operation or part of a systematic destruction of Palestinian culture? Not everyone is in agreement about this … "at the National Library they believed — and still believe — that what is at issue is the act of saving a culture … The Palestinians, on the other hand, view the gathering of the books as "a clear-cut act of cultural plunder, cultural disinheritance, which was an inseparable part of the Nakba, the tragedy the war brought upon them," he adds.
Polish NGO safeguards Palestinian water rights / Amira Hass
Haaretz 8 Dec — The harsh actions of the Civil Administration in the West Bank have made waves in places as far afield as Poland. An NGO there is working to safeguard Palestinians' right to collect water – Israel's ambassador to Poland was summoned to the Polish deputy foreign minister's office in the wake of an article published in the mass-circulation, liberal paper Gazeta Wyborcza. The ambassador was not summoned because of planned construction in E1, but because of a demolition. This happened last February, but the newspaper continues to take an interest in the reason behind the diplomatic event: the demolition of a Palestinian community's old water cistern, which had been restored with Polish government funding through the Polish Humanitarian Action NGO. Judging by comments on the Internet, and discussions held in Polish media outlets and social networks, the fact that Israel was destroying sources of water belonging to the population for whose welfare it is responsible was a shock to quite a few Poles.
Palestinian employment: The phantom workers of Israel / Alon Aviram
972mag 7 Dec — An estimated 30,000 Palestinian laborers work in Israel without permits, in predominantly labor intensive jobs. Pay is poor, social rights are virtually non-existent, and conditions in the workplace are often hazardous. A group of Palestinian workers tell their story from a construction site in Petah Tikva — "This place is a luxury penthouse," said Faisal, 26, a builder from Hebron, as he looked out across the lit city-scape of Petah Tikva. Industrial waste was strewn across the floor, tools were propped up against walls and dust hung in the air on the tenth floor of the construction site. "We've stayed in so many penthouses, you wouldn't believe it!" he said grinning. The shell of a building, in which Faisal stood, is a workplace as well as a temporary home for him and the five other young men in the room. They've lived this life on countless construction sites across the country … "Every two weeks or so the police come and detain us. They take us to the checkpoint and send us back into the West Bank. It's their way of telling us whose boss. But they know we'll just make our way back in," said Faisal.
Violence / Raids / Suppression of popular protests / Illegal arrests
PCHR Weekly Report: 3 Palestinians dead, 14 wounded by Israeli forces this week [29 Nov – 5 Dec]
IMEMC 7 Dec — …the Palestinian Center for Human Rights (PCHR) found that Israeli Forces killed a Palestinian civilian in the southern Gaza Strip. In addition, a member of a Palestinian armed group died of wounds he had sustained in the latest Israeli offensive on the Gaza Strip. The Israeli Forces also killed a Palestinian civilian in the east of Tulkarem. 14 civilians, including 4 children, were wounded along the border fence in the Gaza Strip. Israeli Forces abducted 20 fishers, including 5 children, and damaged a fishing boat's engine.
Israeli attacks in the West Bank: Israeli Forces conducted 47 incursions into Palestinian communities in the West Bank, and abducted 34 Palestinians, including 2 children and a woman with her son, in the West Bank. In the West Bank, on 03 December 2012, the Israeli Forces killed a Palestinian civilian when his car hit an Israeli military jeep on Nablus-Ramallah road. On 01 December 2012, a Palestinian child was wounded when the Israeli Forces moved into Dora village, southwest of Hebron, amidst firing sound bombs. Full Report
Soldiers attack Bil'in weekly protest against wall, settlements
IMEMC 7 Dec — Similar Protests Attacked In Different Parts Of West Bank — The Friends of Freedom and Justice Committee in Bil'in, near the central West Bank city of Ramallah, reported Friday that Israeli soldiers attacked the weekly nonviolent protest against the Annexation Wall and Settlements, built on villagers lands, and fired gas bombs at the protesters leading to dozens of injuries. Soldiers also attacked nonviolent protesters in Nabi Saleh, Al-Ma'sara and Kufur Qaddoum …
The Popular Committee Against the Wall in Bil'in issued a statement in solidarity with all Palestinian political prisoners holding a hunger strike in Israeli prisons, mainly, Ayman Ash-Sharawna, Samer Al-Issawi, Tareq Qa'dan, Ja'far Iz-Ed-deen and Yousef Yassin.
Clashes erupt in Hebron, after Israeli forces provoke Palestinians in Area H1
ISM 6 Dec — Clashes broke out in Hebron on Thursday after a confrontation between Palestinian Authority police and Israeli Occupation Forces. On Wednesday there was a verbal confrontation between a Palestinian Police officer and the Israeli Army. The following day Israeli Forces spotted the Officer while they were on a patrol in area H1 (which is a Palestinian controlled area) and tried to arrest him in Bab Al-Zawiye. Palestinians who witnessed the scene intervened and the officer managed to avoid the unlawful arrest. After the PA Officer avoided arrest, the situation remained tense, as the army would not leave the scene. Israeli Forces then shot tear gas into crowds of civilian bystanders, which quickly escalated the situation. Palestinians became enraged, then clashes broke out between Palestinian youth and the IOF.
Army invades Faqqu'a village near Jenin
IMEMC 7 Dec — Israeli soldiers invaded, on Thursday evening, the Faqqu'a village, east of the northern West Bank city of Jenin, installed roadblocks and searched several vehicles. Clashes were reported and the army fired gas bombs and concussion grenades. The Palestine News & Info Agency (WAFA) reported that the army invaded the eastern neighborhood, and conducted military searches of homes leading to clashes with the residents …
Furthermore, the army installed roadblocks at the entrances of the villages of Al-Yamoun, Rommana, Zabbouba and Ta'nak, stopped and searched dozens of vehicles, and inspected the ID cards of the drivers and passengers; no arrests were reported.
Occupation claims confiscating weapons in Nablus
NAZARETH (PIC) 7 Dec — Israeli sources claimed that an Israeli military force has found, during a military operation carried out at dawn on Thursday, a rifle, ammunition and several knives in the village of Burqa, located to the north-west of the city of Nablus in the northern West Bank … The website of Yedioth Ahronoth newspaper stated that the military operation carried out at dawn on Thursday in Burqa targeted Hamas [See article 500 Israeli soldiers ransack homes in Burqa]
Israeli forces detain 3 minors from Qalqiliya
QALQILIYA (Ma'an) 8 Dec — Israeli forces raided Azzoun village east of Qalqiliya and detained on Friday three teenagers, locals said. Qaies Waddah Shbeta, 15, Mohammad Abed al-Fatah Radwan, 15, and Mohammad Adel Shbeta, 15 were all detained and taken to an unknown location.
IOF arrest five Palestinians in West Bank
RAMALLAH (PIC) 7 Dec — …the IOF arrested, Thursday night, a university student from the town of Tamoun near the West Bank city of Tubas with one of her relatives, after IOF troops aboard several military vehicles stormed the town. According to local sources in Tamoun IOF troops raided the town last night and arrested Iman Bani Odeh (20 years) a student at the Arab American University after storming her parents' house and tampering with its contents, noting that the occupation forces had arrested her brother Anas about a month ago and that he is still under interrogation at Jalama prison. The IOF also arrested Nasser Bani Odeh (36 years), Iman's uncle, and one of the Islamic Jihad activists.
10 Palestinians kidnapped in the West Bank
IMEMC 7 Dec — …Furthermore, soldiers invaded Beit Fajjar town, near Bethlehem, broke into and searched several homes and kidnapped four residents. The four have been identified as Mohammad Ziyad Taqatqa, 21, Mohammad Yousef Taqatqa, 21, Ahmad Abdul-Rahman Taqatqa, 27, and Eyad Mohammad Taqatqa, 30.
Israel detains Palestinians from Salfit
SALFIT (Ma'an) 8 Dec — Israeli forces on Friday morning detained Odai Radwan Ayash from Rafat village in Salfit, his family said. At 1 a.m., Israeli forces raided the house of Radwan Issa Ayash, and destroyed the windows. The forces ransacked the house, and detained his son Odai. They confiscated computer devices and a laptop.
Israel returns body of Palestinian shot by agents
TULKAREM (Ma'an) 7 Dec — Israeli authorities on Friday returned the body of a man killed by Israeli security agents in the northern West Bank this week. Construction worker Hatem Shadid, 37, was shot dead by members of the Israeli internal security service, the Shin Bet, on Monday. His car had collided with their vehicle on a West Bank road, and Israeli officials said he attacked the agents with an axe, a charge denied by his family.
PA security kidnaps two Hamas supporters, summons liberated prisoners
RAMALLAH (PIC) 7 Dec — Palestinian Authority security apparatus continued their violations against supporters and cadres of the Islamic Resistance Movement "Hamas" in the West Bank, arresting two of them in al-Khalil, and summoned two for interrogation in Ramallah. PA services also postponed the courts of 23 Palestinians in Nablus and Qalqilya, and extended the detention of two others.
Political, economic developments / Other news
Islamic Movement elects Sheikh Raed Salah head for a new term
UMM AL-FAHM (PIC) 7 Dec — The Islamic movement in the Palestinian 1948 occupied territories elected a new leadership headed by Sheikh Raed Salah, for a second term … The Islamic Movement also discussed on Thursday the present situation of the movement and its future. It concluded its tenth conference talking about the latest developments taking place in the domestic arena, including the Israeli occupation attacks on Al-Aqsa Mosque and the holy sites in the occupied city of Jerusalem and the issue of racial discrimination from which the Palestinian citizens in the 1948 occupied territories have been suffering.
PA: World should retrieve our tax revenues from Israel
BETHLEHEM (Ma'an) 6 Dec — The Palestinian Authority government on Thursday slammed Israel's seizure of its tax revenues after Palestine won a UN status upgrade as a "policy of piracy". "The international community (should) reject this blackmail and compel Israel to transfer our tax revenues," a PA cabinet statement said Thursday.
Why we lost Pacific Islands
BETHLEHEM (Ma'an) 6 Dec — As Israel reflects on losing Europe in Thursday's vote to upgrade Palestine's UN status, mystery shrouds the positions of four Pacific island nations that broke with international consensus and sided with Tel Aviv … representatives of the Marshall Islands, Micronesia, Nauru, and Palau all refused this week to discuss the vote, dodging calls from Ma'an and even their own aides.
After UN vote, Lieberman cancels visit to Georgia
Haaretz 6 Dec — The United Nations' vote to accept Palestine as a non-member observer state has created a rift in relations not only between Israel and European Union member states, but with other nations as well. One of these nations is Georgia. According to a Foreign Ministry source, a planned visit to Tbilisi by Foreign Minister Avigdor Lieberman, was canceled, as a response to Georgia's decision to vote in favor of the Palestinians' UN bid.
Palestinian journalists conclude safety training in Jenin, West Bank
PNN6 Dec — On Wednesday 5th December, Fifteen Palestinian journalists concluded a three-day training in safety which was organised jointly by the International Federation of Journalists (IFJ) and the Palestinian Journalists' Syndicate (PJS) with the support of UNESCO Office in Ramallah … "The safety of journalists remains of paramount importance to the IFJ and we congratulate our Palestinian colleagues on the completion of this workshop," said IFJ President Jim Boumelha. "We are committed to continuing providing the life–saving skills taught in these courses to many journalists who face security risks in their daily work." The UNESCO support for this workshop followed the official launch of the implementation of the UN Action Plan on the safety of journalists and the issue of impunity during a meeting held in Vienna on 22 and 23 November 2012.
King of Jordan arrives in Ramallah for first visit of foreign leader since Palestine UN upgrade
MEMO 7 Dec — …The King was received by the President of the Palestinian Authority, Mahmoud Abbas, at the presidential headquarters in the West Bank city. The two leaders inspected a military guard of honour while the Royal Jordanian and Palestinian national anthems were played. According to Jordanian press reports, the visit of King Abdullah carried a strong message to the Israelis. "This confirms that Jordan stands alongside the state of Palestine, the Palestinian people and their national rights," said one.
Dismissed teachers continue their protest in West Bank
RAMALLAH (PIC) 7 Dec — A number of dismissed teachers continued their sit-in for the fourth day demanding to return to their jobs after being dismissed for their political affiliation. Ayman Qawariq, one of the dismissed teachers, had declared his open hunger strike, insisting to continue the sit-in outside the Council of Ministers in Ramallah, before being transferred to the hospital on Thursday for treatment due to his hunger strike. Ayman Qawariq, a teacher of mathematics, was protesting with 6 other teachers since Tuesday to meet their demands topped by returning 500 teachers to their jobs.
Switzerland donates $3.2 million to UNRWA
BETHLEHEM (Ma'an) 7 Dec — Switzerland has contributed $3.2 million to UNRWA, the UN agency for Palestinian refugees said Friday. The funds will support UNRWA's regular programs, and follows a Swiss contribution of $11.8 million earlier in 2012, the agency said in a statement.
Analysis / Opinion / Human interest
A week in photos: November 29 – December 5
The Palestinian statehood bid, the ruins of Gaza, nurses strike in Israel, and more: Activestills images tell the stories of the week.
Palestine's new status: Rerun of history or new strategy? / Ramzy Baroud
Ma'an 6 Dec — Palestine has become a "non-member state" at the United Nations as of Thursday Nov. 29, 2012. The draft of the UN resolution beckoning what many perceive as a historic moment passed with an overwhelming majority of General Assembly members: 138 votes in favor, nine against and 41 abstentions. It was accompanied by a passionate speech delivered by Palestinian Authority President Mahmoud Abbas. But decades earlier, a more impressive and animated Palestinian leader, Yasser Arafat sought international solidarity as well. The occasion then was also termed 'historic'.
1000 children to celebrate Christmas in Bethlehem
PNN 6 Dec — Holy Land Christian Ecumenical Foundation (HCEF) said in a press release that HB Patriarch Fouad Twal, Latin Patriarch of Jerusalem, and other religious and civic leaders in Bethlehem will join HCEF's Children's Journey to Bethlehem for Peace on Thursday, December 6, 2012. The Journey to Bethlehem for Peace brings Palestinian children to visit the city of Bethlehem and the Nativity Church. For many of these children, this is their first opportunity to visit Bethlehem, even though they live close by. Mayors of 13 Cities and Towns including Bethlehem, Beit Jala, Beit Sahour, Jifna, Aboud, Ein Ariek, Jericho, Taybeh, Birzeit, Nablus, Zababdeh, and from all over Palestine were invited by HCEF to celebrate this significant Christmas event with the Children of Palestine. The invitation of mayors is intended to make more visible the Christian presence in Bethlehem and throughout Palestine, where many Christians live.
It's more than a hip-hop and a jump to the moon for this Arab-Israeli band
Haaretz 7 Dec — Lod-based threesome DAM have played New York and Paris 30 times, but Jordan and Egypt just once because they have Israeli passports — The idea for the song "Nudbok al Amar" ("Dabke on the Moon" ), the title track of the new album by the Lod-based hip-hop group DAM, was conceived by band member Tamer Nafar while watching the news on television one day. "There were two stories. One was about a research study that NASA is doing on the moon, and the other was about the tunnels in Gaza," he recounts. "It hurt me to see the difference between them. Light-years apart. The Americans are flying to space, and we [the Palestinians] are still digging underground. And they are also responsible for our being in the ground…"
Sayed Kashua's right of return
Haaretz 6 Dec — 'Your Arabic is excellent,' the cleaner of his new home tells him — "Excuse me," the banister installer said, smiling, "I just never imagined that you live here, yes, Sa'id?" "Sure," I said, "sure, forget it." And I really meant that, because it didn't hurt me in the least that he thought I was an Arab worker …"So I have to live in a village to feel I am in a natural place?" I asked. "I'm not allowed city life?" "That's not what I'm saying," she replied, with a patience I was quickly losing. "Then what are you saying?" I insisted. "I really want to understand. What are my options for being natural? To buy some house that is unregistered and unrecorded in the eastern city? To buy a place in the area that was conquered in 1967? To forgo my values for a crappy apartment in an Arab neighborhood in Jerusalem? What? What is natural? To go back to the village? Back to Tira? To the family? To fights between siblings over every meter of land? What is natural? What can I do in order to safeguard the children? Tell me, please, what is right and what is wrong, and I will do it!"
groups.yahoo.com/group/f_shadi (listserv)
www.theheadlines.org (archive)


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Bonney's Gynaecological Surgery, Tenth Edition
Copyright © 2004 by Blackwell Science Ltd
Editor(s): John M. Monaghan, Alberto (Tito) de Barros Lopes, Raj Naik
Published Online: 13 DEC 2007
Print ISBN: 9780632054190
Online ISBN: 9780470752388
About this Book
Product Information
About The Product
Bonney's Gynaecological Surgery has been a firm favourite for gynaecological surgical practice since it was first published in 1911!
In this new tenth edition, this classic of the medical literature has been extensively revised and expanded by three leading gynaecological oncologists. Specifically tailored for trainees in obstetrics and gynaecology, the text focuses on the most commonly performed procedures. This, the tenth edition carries a renewed emphasis on evidence-based decision making, and includes nine new chapters.
For the first time, the authors take into account the increasing use of laparoscopy in diagnostic and surgical procedures, and cover reconstructive surgery, anaesthesia, information technology and audit, complications and quality assurance. Each chapter follows a consistent plan, guiding the reader through each procedure from anatomy and indications to post-op considerations and complications. The text is also accompanied by surgical illustrations of unparalleled quality, ensuring that this volume will remain a valuable resource for all clinicians specialising in gynaecological surgery.


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Zo Rooms Juhu Tara Road Mumbai
Near Tulip Star, Juhu Tara Road Juhu Beach, Mumbai, India
The excellent Zo Rooms Juhu Tara Road offers accommodation in a beach area of Mumbai.
It is placed close to the theater district, in the vicinity of Prithvi Theatre, Adlabs Imagica and Juhu Beach. The property lies within 10 km from the city center.
All 5 comfortable guestrooms feature modern facilities.
Guests can enjoy indian snacks and meals in Lotus Cafe located 150 meters away.
Zo Rooms Juhu Tara Road is within a 5-minute drive to Chhatrapati Shivaji International airport.
The hotel offers newspaper service, dry cleaning and 24-hour room service together with parking, a baggage storage and an elevator for guests' comfort.
- Free Parking
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- 24-Hour Front Desk
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- Elevator
- 24-Hour Room Service
- Tours/ticket assistance
- Newspaper service
- Self-service laundry
Room Amenities
- Individual air conditioning
- Fan/extractor
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- In-room desk
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Near Tulip Star, Juhu Tara Road Juhu Beach, Mumbai, India
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Zo Rooms Juhu Tara Road
Near Tulip Star, Juhu Tara Road Juhu Beach, Mumbai, India
What's nearby
- Local attractions
- Juhu Beach550 m
- Keneri Caves1.2 km
- ISKCON Temple- Mumbai1.3 km
- Adlabs Imagica3.2 km
- Bhau Daji Lad Museum3.7 km
- Jogger's Park4.4 km
- City Center3.7 km
- Mumbai Domestic Terminal 13.0 km
- Airports
- Chhatrapati Shivaji International4.7 km
- Train stations
- Mumbai Central14.7 km


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On any given afternoon when I was in elementary school, my friend, Dana Fleming, and I could be found balancing on either side of some railroad tracks.
We'd follow this path until we got to Knox Street, where we would either grab a malt at Highland Park Pharmacy or an afternoon snack at Chili's.
With either one we chose, we surely ruined our appetites for dinner.
Today, the same pathway we walked along couldn't be more popular; now, there are crossing paths at Knox Street and Harvard Avenue where we used to run through breaks of traffic.
The Katy Trail has been developed and popular for years now, but there is at least one other location that is using underutilized land for a trail. It's worked in the past, and some people are thinking it will work again.
On the Trinity Strand Trail, there is already some concrete down on the pathway that winds beside the Old Meanders.
The Old Meanders is the waterway that was once the Trinity River. After a major flood in 1908, the river was rerouted to the west, in between levees and where we know it to be today.
After finding this out, I went straight to Our City Dallas, an interesting read from 1927, when author Justin F. Kimball took a look at the city and the plans George E. Kessler had for it.
In one chapter of this book, Kimball discusses flood after flood. In 1866, for example, a flood more than 49 feet was reported: "The Dallas newspaper of that time says that Dallas stood on an island; that the only road that was impassable because of deep water was the one which follows the present line of Ross Avenue, and there were places on that road where the water was very deep," he wrote.
It's no wonder the river's former location was a problem. The flood of 1908 was recorded as reaching 52.6 feet.
"Mr. Kessler told us that the simplest and cheapest way of managing the Trinity is by straightening its channel, cutting out the bushes, trees and weeds that now fill the bottom lands, and by building levees above flood level on each side of the river," he wrote.
I guess the rest is history; but as for Old Meanders' former spot, there wasn't much going on, said Shelly White, executive director of the Friends of the Trinity Strand Trail.
White, along with other trail volunteers, think the look of the area will soon change.
She believes businesses will eventually back up to the trail — doorways in back, porches overlooking it — a sight that would be more pleasant to look at than the brick walls that now line the area, she said.
For more on the current state and future plans of this trail, read this week's cover story.
Post your stories, events and news items online at neighborsgo.com for a chance to appear in one of our 11 print editions.


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What would you include in a obituary about Julius Caesar in William Shakespeare's play, The Tradegy of Julius Caesar?I'd be really helpful if you could provide a couple of examples or starters....
I'd be really helpful if you could provide a couple of examples or starters. I've already gotten a good opening paragraph, and I'd really like it if you could also help with the personality bit... :D Thank you in advance!
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3 Answers
Julius Caesar was a general who never lost a war, a statesman, a lawgiver, an orator, an historian, and a mathematician whose government endured for centuries. His is the man who fixed the calendar, adding July and August to the year. He created the first newsheet, Acta Diurna (Acts of the Day) which informed the public of the goings-on of the Assembly and the Senate.
Under Julius Caesar, Rome built its empire. With so many large-scale, enduring wars being waged, Rome placed dictators in power, but they were to step down once the crises were over. However, Julius Caesar made himself dictator for life (perpetual dictator). In this act, he demonstrated his tyranny. He was, indeed, ambitious. However, he accomplished much.
Depending on the perspective you will be using (who is writing and when), you might include news of Caesar's murder. Caesar can be painted as a hero and a martyr. A brilliant military leader, Caesar was also a casualty of political warfare.
User Comments
If I were to write an obituary about Julius Caesar I would have to look beyond what is just represented in the play. I would look at his accomplishments and then tally them up. In the play Caesar is bringing himself to the throne to try and become king of the Romans. The leader is very self-proud which is the reason that he was killed. The senate was concerned that if he became any more powerful he would lay claim to the country. Since an obituary is meant to be kind words spoken, one would not state those facts.
Here are some of Caesar's good qualities.
-He was intelligent.
-Well loved by the people.
-A strong leader.
-Committed to Rome.
-An excellent and wise general.
-A good and devoted husband.
-A father to Rome.


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Willits senior running back Wyatt Sanderson is back in the Wolverine lineup, and it couldn't have come at a better time.
Sanderson has been sidelined with a knee injury since early September; in his absence, his teammates have stepped up and made adjustments to fill the void their leading rusher left.
"It was a drag to be out, but I knew I was going to be able to return and make up for the games I missed, so I just stayed focused," said Sanderson.
Like they have done so many times this season, the Wolverines stepped up throughout the lineup, and it resulted in a 30-14 league win over the Clearlake Cardinals last Friday night at Maize Field.
Sanderson, in his first game since September 7 against Ukiah, was given a chance to return the favor to his team in last week's game.
With Willits quarterback Kailer Collicott out of the lineup following last week's concussion, Sanderson stood in to take his place.
"I have never really played quarterback, but we needed one so I had to step up," said Sanderson after the game. "It felt good to be back."
Sanderson finished the game with 130 passing yards, completing five of eight passes, including a touchdown pass. He also had two rushing touchdowns and ran for close to 100 yards.
Will and Wyatt King had several carries in the game for Willits. "With Kailer out of the game and Wyatt [Sanderson] at quarterback-those are our two main runners normally-and so the King brothers helped out and carried the ball quite a bit," said Coach Nat Collicott.
Wyatt King had a season high 30 carries, while brother Will carried 25 times, also a season high.
"We played hard and had the determination to bounce back from the loss against Middletown," said Will.
In the second quarter, facing third and long, the Wolverines were unable to complete the pass, but the Cardinals were called for pass interference, and Willits was granted an automatic first down. The Wolverines eventually scored on a 1-yard run to go up, 14-0.
Willits held Clearlake to just 51 yards rushing and forced the Cardinals to abandon their running game and move the ball in the air instead. They completed 7 of 15 passes for 109 yards.
Clearlake avoided the first half shutout and managed to score a touchdown with only 56 seconds left. It came on a drive that began with an interception thrown by Sanderson in the final two minutes of the second quarter.
While fumbles have haunted the Wolverines in previous games, they were happy to note they did not turn over the ball once against the Cardinals.
The Wolverines were also playing without the injured Reis Renkin, but the tight end, receiver and outside line backer is expected to return this week along with Kailer.
"I'm proud of the team, they played great together," said Kailer Collicott. "I was upset I couldn't compete, but my health is important to me.
"I'm feeling 100 percent now and I am ready to get back to the field."
Despite the constant shuffling of positions due to the numerous injuries that have afflicted the team, the Wolverines remain confident and believe they will be visiting the post-season again this year.
"We are definitely getting healthy at the right time," said Coach Collicott. "Two years ago we were doing amazing at the beginning of the year, then toward the end we had bad injuries that prevented us from going to the playoffs.
"Last year we had the injuries early, but we were able to overcome them and we rolled through pretty good. This year we've had the injuries early," eh said, "and I think we are getting healthy at the right time. Hopefully, we can stay healthy towards the end of the season when it really matters."
Willits (2-1 league, 4-2 overall) has yet to lose a home game, and they hope to keep that streak alive tonight when they host Cloverdale.
The Eagles (1-2, 1-5) beat Kelseyville in a nail-biter last weekend, 41-40. Prior to that game, they were winless on the season.


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One of the nicest gifts for someone you love is Juno Active. We do not currently offer gift cards, however, our return policy is extremely convenient to ensure confidence when ordering our products as a gift. The return policy on gifts is 30 days after the gift is purchased. Please call customer service at 1-800-586-6642 if a return or exchange is needed so we can help.
Read more details on our Return and Exchange Policy here.


text:
DEVELOPERS looking to build a 68-bedroom hotel close to a rugby stadium say they hope the plans will boost tourism in the area.
A planning application for a five storey T-shaped hotel on a vacant patch of land next to the The Northern Echo Arena, on the outskirts of Darlington, has been submitted to Darlington Borough Council by agents PlanArch Design.
The proposed three star hotel would stand independent of the Mowden Park Rugby Club-owned arena, overlooking the A66 bypass, but with access through the arena's car park, which is entered from Neasham Road.
A statement submitted to planners by PlanArch states that the hotel would provide customers with a level of accommodation "not currently available in Darlington" and would complement the facilities available at the Darlington Arena.
The developer has proposed to build the hotel on a small, triangular piece of land that stands empty and surrounded by hedgerows.
In its report to the council, the design agents acknowledge some of the limitations of the site, including the need to cut back established hedgerows to clear the land and the proximity of the busy A66.
However it adds: "The site is in a highly visible and accessible location to attract visitors from both the corporate and tourist sectors, as well as sports fans to the stadium.
"The proposed hotel is ideally situated to complement the stadium and its ancillary uses."
Since being taken over by Mowden Park, the arena has seen a number of new businesses open to the public, including gyms, a physiotherapist and a nursery, on top of its sporting function.
The developer said it is keen to differentiate the proposed hotel from the arena by using a different colour palate but that the two facilities would work in harmony together.
The report said: "The hotel building itself will be visually identifiable in its own right, as well as being complementary to the adjacent stadium.
"It is considered it will provide an important statement on an important national route in respect of the vitality and aspirations of Darlington in its gateway role to the region."
The planning application for the hotel is in its early stages and will be considered by council planning officials once comments from interested parties are submitted.


text:
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War Hawk
Amstrad CPC - 1986
Also available on: Atari 8-bit - Commodore 64
Description of War Hawk Amstrad CPC
Developed by Proteus Developments and published by Firebird Software, War Hawk (also known as Warhawk, Proteus) is a action game revolving around sci-fi / futuristic, shooter. It was published in 1986, feel free to download and play it now!
Captures and Snapshots
Screenshots from MobyGames.com
Screenshots from MobyGames.com
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Amstrad CPC Version
Atari 8-bit ROM
- Year: 1986
- Publisher: Firebird Software
- Developer: Proteus Developments
Commodore 64 Version
- Year: 1986
- Publisher: Firebird Software
- Developer: Proteus Developments
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text:
Three Swiss cities among most expensive for expats
Geneva, Zurich and Basel remain in the top 10 most expensive cities for expat workers, according to a new survey.Luanda -- Angola's capital Luanda has again been rated the most expensive city in the world for expat workers, followed by Tokyo, according to a survey published on Wednesday, while the Swiss cities of Geneva, Zurich and Basel all make the top 10.
The latest Cost of Living Survey by human resources consultancy ECA International saw Luanda maintain top spot on the world priciest locations for foreigners, while Maseru in the small mountain state Lesotho was the cheapest.
The next three cities in the ranking after Luanda and Tokyo were all in Japan--Nagoya, Yokohama and Kobe--according to the report.
Oil rich Angola's has enjoyed an unprecedented economic boom since a 27-year civil war ended in 2002 which has attracted an influx of foreign workers.
The country's war-damaged industry and poor infrastructure means the bulk of food, construction materials and other goods have to be imported, driving up costs.
Decent Luanda apartments with water and electricity go for upwards of 15,000 dollars (10,700 euros) a month, a basic meal out can top 100 dollars and imported European cheese sells for over 15 dollars a piece.
The high prices sit incongruously next to the rest of Angola's poverty with two thirds of the population living on less than two dollars a day.
Maintaining their position in the top ten were Copenhagen in Denmark, Oslo in Norway and the Swiss cities of Geneva, Zurich and Basel.
ECA's cost of living data, conducted twice a year, compares a selection of 125 consumer goods and services in over 370 locations worldwide.
AFP / Expatica


text: I did our trip report on our family website and have sent people there to read it several times. I decided I need to put it on here so everyone can read it. I am just copying the report from our website so it may have some extra stuff in it along with the actual trip info. Our cast of characters is me, DH, Mickey (wish kid - leukemia patient at the time; leukemia survivor now!), Brad our super son! April 29, 2006 Greetings from beautiful Florida!! We have had a very full, wonderful day. It started with the kids being up and ready 30 minutes before the limo was due to arrive. We were picked up at 4:00 AM in a white stretch limo. Thanks, Newcoms!! Brad talked the driver's ear off the whole way! When we got into the airport, we noticed a family with a teenage boy wearing a Wish Fund T-shirt. They had a young girl with them and Mickey immediately started talking. Long story short, Mickey has a new best buddy named Chelsea from Ft. Wayne. The flights were great. The kids really enjoyed their first flights! They even got to go into the cockpit in Atlanta and meet the captain. We were several hours too early to check into the Village, so we took the kids to Downtown Disney for lunch and shopping. Mickey got a bunch of My Little Pony things and Brad found a Star Wars Transformer and a little Lego toy. He loved the Lego Store with all the HUGE Lego sculptures all around. Mickey found a water play area and got absolutely soaked!! We dried her off by sitting by the lake eating sundaes from the Ghiradelli Soda Fountain! YUM!!! Give Kids the World Village is simply incredible. All the people are so gracious! Mickey's new friend, Chelsea, is in a villa just down the street from us so we've seen quite a bit of her and her family. So far we've gone swimming, ridden the train, carousel and tram and helped Mayor Clayton, the Village's mascot, celebrate his birthday. It's been very, very busy. Tomorrow we will take the kids to Islands of Adventure to celebrate Brad's 7th birthday. We are very excited about the breakfast with Spiderman, which is a complete surprise to him. Brad with Mayor Clayton at GKTW Mickey in GKTW pool


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Carclo Triple Lensholder 50mm for Luxeon Rebel, Cree und Nic
Save time and energy with our lens holders by Carclo. The lenses can be easily clipped into the holder and are quickly attached to the LEDs.
The versatile range of products provides you with the appropriate holder for every lighting application.
Note:Select your holder in due consideration of compatibility with LEDs and lenses!
Suited for the following LEDs
- Lumileds: Luxeon Rebel, Luxeon Rebel ES
- Cree: XP-E
- Nichia: 036
Suited for the following lenses
- 60311: Plain tight
- 60312: Frosted narrow
- 60313: Frosted medium
- 60314: Frosted wide
- 60315: Elliptical
Further technical details can be found in the data sheet.
LUMITRONIX is official Carclo distributor
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Saving the Titanic
She was the pride of the British Empire. A leading example of state-of-the-art engineering in a time of groundbreaking scientific and technological innovations on a global scale: the RMS Titanic. Yet she sank in less than three hours after striking an iceberg on 14th April 1912. We all know about the many deaths in the icy waters, the fates of the rich and famous on the ship's maiden voyage and the dramas that played out in the Titanic's last hours. What is less known however is how a team of shipbuilders and engineers attempted to save the stricken vessel.
Seeking to answer the question of what happened in the engine and boiler rooms after the collision, producer Stephen Rooke and director Maurice Sweeney's film Saving the Titanic tells the story of the disaster from below deck, with the action taking place between the time the crew embark the Titanic at Southampton and the eventual sinking of the ship.
Narrated by leading Irish actor Liam Cunningham and based upon eye-witness accounts, this is the remarkable story of nine central characters from the engineering crew as they work among the huge, coal-fired furnaces heating the boilers and massive dynamos whirring to satisfy the ship's demand for electricity. These nine men - among them leading fireman Frederick Barrett, chief engineer Joseph Bell, Sligo man electrician Alfred Middleton, assistant electrician William Kelly from Dublin and 18-year-old electrical engineer Albert Ervine from Belfast - are the heroes of this epic film. Their personal stories of bravery are recounted as the men fought courageously to hold back the power of the sea and keep the power systems running, even when they learned that all was lost. Most of these men died but their actions saved many lives.
PRODUCER - Stephen Rooke
CO-PRODUCERS - Reinhardt Beetz & Keith Farrell
DIRECTOR - Maurice Sweeney
WRITERS - Lyall Watson & Colin Heber Percy
COMPOSER - Steve Lynch
NARRATOR - Liam Cunningham


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UK's 'last typewriter' produced
A typewriter, which its makers say is the last to be built in the UK, has been produced at a north Wales factory.
Manufacturer Brother, which says it has made 5.9 million typewriters since its factory in Wrexham opened in 1985, has donated the last machine to London's Science Museum.
The museum said the piece represented the end of a technology which had been "important to so many lives".
Edward Bryan, a worker at the factory since 1989, made the last typewriter.
Colin Paterson reports.
20 Nov 2012
- From the section UK


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After hearing several people voice concerns about proposed cuts to public safety, the Eureka City Council voted unanimously to adopt the $69 million 2014-2015 fiscal year budget with an amendment to restore some of the cuts by pulling money from the city's reserves.
Finance Director Paul Rodrigues said the estimated $200,000 to bring back public safety priorities will be pulled from the city's $1.4 million reserves.
"I'm concerned, but it's the council's budget. They just listened to the public," Rodrigues said, adding it's policy to have about a $4 million or 60-day reserve. "As finance director, I'm nervous."
During public comment, people asked council members to honor their promise to allocate Measure O, the city's increased sales tax, funds toward public safety and to not cut their budgets.
"Everybody voted for Measure O believing it would enhance public safety," Eureka resident Lorraine Dunaway said. "It's everybody's top concern, and it's the only thing everybody is talking about when we're out there."
Other community members said they've had break-ins at their homes.
Former Eureka City Councilman and 4th District Supervisor candidate Chris Kerrigan said the high crime rates are hurting sales tax revenue.
"I do want to come speak in favor of fully funding public safety in Eureka, especially police," Kerrigan said. "I think we've really got to make sure we focus on getting a handle on the crime rate in our neighborhood."
After public comment concluded, Councilwoman Melinda Ciarabellini, who previously said she wasn't in favor of the proposed cuts, said $4 million out of $4.1 million in revenues from Measure O has been allocated for public safety, which accounts for 75 percent of the recurring costs in the general fund.
"I challenge you to look at any other city and see how it compares," Ciarabellini said. "If that's not a commitment to public safety by this community, I don't know what is."
Heading into Tuesday's meeting, the Eureka Police Department and Humboldt Bay Fire were instructed, like all other city departments, to cut 10 percent from their budgets.
Eureka police Chief Andrew Mills originally planned to cut a little over $1 million from his budget. He proposed trimming $460,000 worth of personnel expenses, including overtime and training. He also said he planned to reduce personnel costs by $600,000 by eliminating one position, freezing others and delaying promotions.
"The bottom line is we're prepared to make the city as safe and as liveable as possible with whatever budget they give me," Mills said. "It just makes it harder to do it the more they cut out my budget. But we're prepared to march forward."
Humboldt Bay Fire Chief Ken Woods said as a result of this year's budget, he would have to eliminate one assistant fire chief position, effective in December, and freeze two vacant firefighter positions. Two battalion chiefs will would have been demoted to captains.
The department also planned to make cuts to its program and equipment budgets, Assistant Fire Chief Bill Gillepsie said. The department was going to cut a total of just over $662,300.
The overtime, training and in-car cameras were all saved for the police department. Training, equipment and the battalion chief positions were reinstated for Humboldt Bay Fire.
While the costs will initially be covered through the city's reserves, the council directed staff to create a public safety reserve. It will be funded through additional expenditure savings and possibly through early retirement incentives, which are projected from this years budget, City Manager Greg Sparks said.
The 10 percent cuts are needed to balance the budget because expenditures have risen while revenues have plateaued, Rodrigues said. There has also been an unexpected spending increase of nearly $900,000 since the 2010-2011 fiscal year due to employee benefits and health care expenses skyrocketing, he said.
Even with Measure O, fire and police costs have risen by about $5 million, according to the finance department.
"That puts a crimp on things because Measure O is only bringing in $4 million," he added. "Regular sales taxes ... haven't been increasing for the last two years."
The adopted budget takes effect July 1.
Contact Lorna Rodriguez at 441-0506.


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Like many little brothers, Tyler Lu looked up to his big brother.
Once Austin decided to play tennis, Tyler decided he would give it a try.
Although Tyler's entry into the sport was late by typical standards, he quickly made up ground through hard work and dedication.
The reward came when Tyler committed to play at Yale University. The blue chip recruit from Irvine, Ca., will begin attending classes in the fall.
"Going into the recruiting process my main goal was definitely to pursue a school for its academics, and tennis gave me that opportunity," Tyler said. "I pretty much focused exclusively on the Ivy League schools, and I felt that Yale was the top tier of the Ivies. I felt it had the best balance between social life, academics and athletics."
Tyler didn't start playing tennis until he was 12, and he didn't focus exclusively on the sport until he reached high school.
He always kept busy with practices for basketball, baseball, soccer and swimming.
"It turned out as I got older I started liking tennis more than the others," Tyler said. "I think the best part about tennis for me is the individuality, how the outcome is based on yourself only. You take the blame for a loss and take the glory for a win."
Austin wasn't surprised when his little brother quickly began making up ground on the court.
"From the start, anything I would get into he would also try to get his feet wet in as well and it turned out tennis was something he really took to," said Austin, 21, who attended UCLA and played club tennis. "He has a lot of ambition, and he picked tennis up really fast and ran with it obviously."
Full Listings: Boys' Commits & Girls' Commits


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c.1900 Lyon & Healy Oak/Spruce Tailpiece Guitar
5 comments:
I found a modern builder using oak named Johann (Hans) Brentrup in Minnesota. He is pretty famous for making mandolins. I played one of his oak parlors (he also makes a killer 12 string based on a Larson Brothers design). Unfortunately his guitars are in the $4K range and, although worth the $$, way out of my league. Why DON'T more builders use quartersawn oak in the modern era? Any thoughts from a manufacturing standpoint?
- August 19, 2011 at 9:37 PM
- Antebellum Instruments said...
Ben: It's just personal taste. Since the late 1800s the industry has had a bias towards rosewood, mahogany, or maple, and the advertising has simply been so ingrained that folks have a hard time getting off of that horse. Thankfully, people are SLOWLY getting more accustomed to different tone choices -- oak is lovely, as is cherry and walnut, too.
- August 19, 2011 at 10:42 PM
Thanks for the reply Jake. Do you know other oak builders I could check out?
Also, inventory update still coming? Inquiring minds want to know.
- August 22, 2011 at 3:06 PM
- NFL Jerseys said...
i found that your blog is very useful, it tell me a lots things i even know before
thanks for your post
i will be back and i hope you can tell me some others info
- October 15, 2011 at 3:27 AM
Hey Jake, I'm very happy to have found your post with photos of the L&H guitar. It IS an American Conservatory. I have one almost exactly like the one shown that belonged to my Grandfather. Inside the sound hole is a very simple sticker that reads:
American Conservatory
No. 480
The only differences seem to be that the face of yours shown has the decorative band around the edge and the "button" on the bottom, otherwise all the hardware is identical, neck/head and body are the same.
In the late 20's & early 30's Granddaddy played it at "barn dances" in the s.e. Colorado area. I'd like to send a photo or two but I'm not sure how to attach them.
- August 17, 2012 at 8:22 PM


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Ganta Srinivas Rao @ Srimanthudu audio launch - NTv
Sat, Jul 18, 2015, 09:44 PM
Srimanthudu is the upcoming movie of Mahesh Babu and it is directed by Koratala Siva. The movie stars Shruti Haasan opposite Mahesh Babu as the heroine and other star-cast include Jagapathi Babu, Brahmanandam, Rajendra Prasad, Sukanya, Sampath Raj, Harish Uthaman, Rahul Ravindran. This movie is produced under the banner Mythri movie makers in association with G Mahesh Babu Entertainment Pvt Ltd. Ganta Srinivas Rao speaking at the audio launch has said that he watched the trailer of the movie and appreciated for the social concern involved in the movie. Listen to Ganta . . . .


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About the Book
Proper Boston Brahmin Juliet Rose Astor Lowell doesn't want her body guarded by anyone while she's in New Orleans for the grand opening of Daddy's new hotel—especially not by macho cop Beau Dupree. He's too big, too pushy, too virile, too . . . everything! His shameless, hungry-eyed gaze shakes her carefully cultivated decorum. But Juliet is a Lowell—and there's no way she's ever going to lose control!
Beau has more important things to do than babysit a beautiful Yankee rich girl. By driving the well-mannered socialite beyond the bounds of her good-girl restraints, he figures he can get himself pulled off of the assignment. But who would have thought that real passion sizzled beneath Juliet's polish—or that when she lets her hair down, she just might prove to be more woman than Beau can handle?
Educator and Librarian Resources
Product Details
- Imprint: Avon
- On Sale: 08/28/2012
- Trimsize: 4.188 in (w) x 6.75 in (h) x 0.96 in (d)
- Pages: 384
- List Price: 7.99 USD
- BISAC1: FICTION / Romance / Contemporary


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Mortality rate maternal
mortality rate, maternal
The number of maternal deaths related to childbearing divided by the number of live births (or by the number of live births _ foetal deaths) in that year. The maternal mortality rate in the united states in 1993 (and 1994) was 0.1 per 1,000 live births, or 1 mother dying per 10,000 live births.
Please contribute to this project, if you have more information about this term feel free to edit this page.


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Picasso visited Britain twice but his influence on our art scene was seismic
Picasso only visited Britain twice but his influence on our art scene was seismic, and now Tate Britain is staging an exhibition that tells his story of a grey, damp, conservative England.
In a farmhouse kitchen in Sussex, there is a small corner that will be forever Spain. âWhen Picasso was here, he took a liking to our Ayrshire bull, William,â says author and curator Antony Penrose, who still lives in the house bought by his parents, the surrealist painter Roland Penrose and the photographer Lee Miller . âSo in this picture [an exuberant painting hanging above the kitchen table], that Ayrshire bull has become mixed with an Andalucian bull. Only Picasso could have given something as heavy as a bull a pair of wings and balanced him on a twig.â
Pablo Picasso stayed at Farley Farm House just once, in 1950, and only came to Britain twice; the first time in 1919 with the Ballets Russesâs The Three-Cornered Hat, for which he had designed the set and costumes. But that farmhouse, or more specifically its former owner, Roland â the leading curator and champion of Picasso in Britain â is partly responsible for ensuring he had the impact he did on modern British art before and after World War II. âFor my father, Picasso contained the keys to a world of the marvellous,â says Antony. âHis painting was all about wonder and imagination and all that can be done.â
Now Tate Britain is staging an exhibition that tells precisely that story: that in grey, damp, conservative England, young British artists from Bloomsbury to Bradford were hungrily devouring everything the radical, mercurial Picasso had to teach them. From Duncan Grant, a Bohemian aesthete during World War I, to David Hockney , an eager art student in Yorkshire 50 years later, Picassoâs shocking revolutions in cubism, surrealism and figurative art were being feverishly and profoundly absorbed and reconfigured.
âModern British art has always been seen as following in Europeâs wake,â says Chris Stephens, curator of Tate Britainâs Picasso & Modern British Art. âSo the exhibition looks at the history of Picasso in Britain and how his work was collected and communicated. But it also looks at artists influenced by Picasso who were good enough in their own right. They werenât just copying but doing something original with it.â
Itâs hard to understand today just how resistant the establishment was to modernism and Picasso before the Tateâs landmark 1960 blockbuster exhibition, curated by Penrose. Evelyn Waugh used to sign off his letters with âdeath to Picassoâ. A successful attempt by the Tate to buy his Three Dancers as late as 1965 prompted questions in parliament.
Nor, with the exception of early exhibitions curated by Roger Fry, was his work easily accessible before the 1930s. An exhibition in 1921 had been so disastrous that no-one else tried for at least ten years, says Stephens. The 1938-39 tour of Guernica, partly organised by Penrose, attracted record crowds in working-class Whitechapel but virtually no interest at all in Mayfair.
Yet for the artists gathered in Stephensâs new show, Picassoâs influence was seismic. Like a hologram, he reflected different possibilities depending on who was looking. Francis Bacon hadnât even intended on being an artist until he saw Picassoâs paintings in Paris â he was an interior designer with a penchant, apparently, for white rubber curtains. âHe said himself his 1933 painting Crucifixion was a response to Picassoâs Bathers At The Beach Hut [1925],â says Stephens. âBoth Henry Moore and Bacon found in Picassoâs early figurative work a distortion that for them was expressive of human existence, a sexual aspect and the potential for violence.â Ben Nicholson, meanwhile, embraced Picassoâs love for the purely decorative. âYou see Nicholson really taking forward the idea of using patterning for its own sake with his use of diamonds and wavy lines. While for Hockney, who went to the Tateâs 1960 exhibition eight times, the fundamental realisation was that you didnât have to restrict yourself to one style. You could be many things, often at the same time.â
In 1950, Picasso was actually en route to the World Peace Conference in Sheffield but changed his mind after the Home Office refused visas to many of the delegates attending and stopped over with Penrose instead at Farley Farm House. (Itâs now a museum dedicated to Miller, Penrose and British surrealism.)
âHe smelt of Gauloises and cologne,â remembers Antony, who was three years old at the time. Later, Antony would go with his parents to visit Picasso in his studio in the south of France, as did Henry Moore and Duncan Grant. âHis studio was full of pets but also full of sculptures made from pets, as though he had a way of crossing a barrier between living and made things,â he says.
Yet if Picasso held for the British an exotic vitality, he had a love affair with England. âHe was really struck by the softness of the light,â says Antony. âHe said after coming here he understood Constable.â
As a young man, he was also fascinated by Oscar Wilde, Aubrey Beardsley, Victorian explorer Lady Stanhope, and the Pre-Raphaelite Edward Burne-Jones. âI like to think that in 1919 he might have come to the Tate to see the Burne-Joneses,â says Stephens. âIf you look at his blue period, thereâs something very Pre-Raphaelite about those limpid, melancholic women.
âIn fact, when Picasso left Barcelona in the early 1900s, he was actually on his way to London. Unfortunately, he stopped off in Paris and never got any farther.â
Picasso & Modern British Art opens tomorrow at Tate Britain ( www.tate.org.uk ) then at the National Galleries Of Scotland, Edinburgh, from August 4 ( www.nationalgalleries.org ). www.farleyfarmhouse.co.uk


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, 2016-01-07 02:08
FDA confirms rat study results are reason for arimoclomol trial hold
According to a Feb. 11 press release from CytRx, developer of arimoclomol, the company has received written correspondence from the U.S. Food and Drug Administration (FDA) clarifying the agency's decision to place a hold on the phase 2b trial of arimoclomol in ALS. (See "Arimoclomol trial," MDA/ALS Newsmagazine, March 2008.)
The FDA has confirmed CytRx's understanding that the agency's decision pertained to a previously completed toxicity study in rats and was not related to data from any human arimoclomol studies.
Steven Kriegsman, CytRx's president and CEO, is quoted as saying the company will "take the necessary steps to resolve this matter as expeditiously as possible" and that it plans to "work with the FDA to address their questions and allow us to move forward with our phase 2b trial."
Two new research papers, both published in February, show that mutations (flaws) in the gene for the TDP43 protein can result in familial and sporadic (nonfamilial) ALS.
Nigel Cairns at Washington University School of Medicine in St. Louis, and colleagues, announced online Feb. 20 in Annals of Neurology that a mutation in the gene for TDP43 is the cause of ALS in a family of European descent.
And a week later, Christopher Shaw at King's College London, and colleagues, published findings online in Science Express showing that a TDP43 mutation caused ALS in a family of British descent and in a few people with nonfamilial ALS. (Out of 2,500 unaffected people who also were screened, only one had a TDP43 mutation.)
These findings come shortly after the announcement last spring that abnormal cellular clusters containing TDP43 are present in sporadic ALS and in the type of familial ALS that's not related to the SOD1 gene, but are not present in SOD1-related ALS; and a subsequent finding that a deficiency of the protein progranulin leads to fragmentation and mislocation of the TDP43 protein in cells.
These results could mean TDP43 is a factor in the ALS disease process and that its apparent involvement only in non-SOD1 ALS signifies a difference between SOD1-related ALS and the other more common forms of the disease.
Scientists now should be able to breed mice with TDP43 mutations and further explore TDP43's actions.
"It will be very interesting if academics can develop a TDP43 animal model that mimics ALS in a robust fashion," wrote John McCarty, treatment investigator at the MDA-supported ALS Therapy Development Institute in Cambridge, Mass., on the Institute's online forum (als.net/forum) March 4. McCarty cautioned that the presence of TDP43-containing clusters in ALS-affected cells doesn't necessarily mean the protein plays a disease-causing role.
However, he noted, mice with TDP43 mutations "would be a very welcome new tool for us and other researchers."
Nerve-muscle signals are a two-way street
Chemical signals from nerve cells are known to influence muscle cells. Lin Mei's team has found that signals from muscle cells also influence nerve cells.
Researchers in the laboratory of MDA-supported Lin Mei at the Medical College of Georgia in Augusta have found that muscle fibers do more than passively receive signals from nerve fibers that tell them to contract or relax.
Instead, say Mei and colleagues, who published their findings online in Nature Neuroscience Feb. 17, "backwards" (retrograde) signals coming from muscle fibers to nerve fibers profoundly influence nerve-fiber location and function. The finding could have implications for ALS, in which nerve cells that interact with muscle fibers degenerate.
When the investigators bred mice lacking a protein called beta-catenin in their muscles, they saw that branches of the phrenic nerves, which go to the respiratory diaphragm, were mislocated in the diaphragm muscle and that signal transmission was reduced.
However, when beta-catenin was depleted only in nerve cells in the mice, they didn't have this type of neurological problem.
"These observations demonstrate that muscle beta-catenin is a key ingredient for neuromuscular junction formation," Mei said, referring to places where nerve and muscle fibers meet. The findings also showed that beta-catenin may control other proteins necessary to nerve-cell health, she added.
"Muscles are known to produce elusive nutritional factors for nerve-cell survival and development," Mei said. "And these findings could provide leads to their identification."
VEGF-B may save nerve cells without collateral damage
A protein called vascular endothelial factor B (VEGF-B) appears to protect nerve cells without causing unwanted proliferation of blood vessels, as its chemical relative VEGF can do, says a new report in the Journal of Clinical Investigation.
Xuri Li at the National Institutes of Health in Bethesda, Md., and colleagues, who published their results online Feb. 7, describe how treatment with VEGF-B injections rescued nerve cells in mice with injuries to the retina and optic nerve, without undesirable effects. They conclude that VEGF-B might provide a new option for treating different types of neurodegenerative disease.
MDA is funding Peter Carmeliet at the Flanders Interuniversity Institute for Biotechnology in Ghent, Belgium, to study VEGF and VEGF-B in rodents with ALS.
Review of evidence supports link between toxic exposures and illness in Gulf War vets
A review of multiple studies of veterans of the 1990-1991 Persian Gulf War who developed ALS and other illnesses strongly supports a link between illness and exposure to chemicals known as acetylcholinesterase inhibitors (AChEis). (This topic was explored in "ALS and Vets: Searching for Connections" in the March 2008 issue.)
In this new review, published March 18 in Proceedings of the National Academy of Sciences, Beatrice Golomb at the University of California-San Diego describes 21 studies of Gulf War veterans that link this type of chemical exposure to later development of a variety of health problems.
The AChEis studied included pyridostigmine bromide, a medication given to some 250,000 Gulf War service personnel to counteract expected attacks with toxic nerve agents; carbamate and organophosphate pesticides, which were aggressively used in that conflict to control insects and to which 41,000 service members may have been overexposed; and sarin, a nervous-system toxin to which the Department of Defense estimates about 100,000 personnel were possibly exposed after demolition of a munitions depot.
The review also found that low activity levels of two enzymes involved in detoxification of AChEis (PON and BChE enzymes) also correlated with the presence of illness. Genetic variations are one cause of activity level variation in these enzymes.
The author notes that emerging evidence links ALS incidence to PON gene variants and perhaps their interaction with AChEi pesticides. She says this evidence supports a connection between organophosphate pesticide exposures during the Gulf War and the observed elevated rate of ALS development in Gulf War veterans.
Perspectives on life with ALS