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Needle-free Jet Injection of Reduced-dose, Intradermal, Influenza Vaccine in >= 6 to < 24-month-old Children
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|Biological: Vaxigrip® trivalent inactivated influenza vaccine Device: Intradermal spacer on Biojector® 2000 jet injector
|Phase 1 Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
|Official Title:
|Clinical Trial of Safety (Reactogenicity) and Immunogenicity of Needle-free Jet Injection of Reduced-dose, Intradermal Influenza Vaccine (INF) Administered to >= 6 to < 24 Month-old Infants and Toddlers in the Dominican Republic
- Rates of seroconversion (SC) on HI assay 1 month after dose 2. SC defined as titer >= 40 among initial-seronegatives (titer < 8 on day 0); OR, a followup titer which rises >= 4-fold. [ Time Frame: One month after each of doses 1 and 2. ]
- Rates of local and systemic reactions [ Time Frame: Up to 42 days for prompted symptoms after investigational doses 1 and 2. Up to 6 months for unsolicited ones. ]
- Seroprotection (SP) on HI assay, defined as >= 40 regardless of baseline [ Time Frame: One month after each of doses 1 and 2. ]
- Geometric mean titers (GMT) on HI [ Time Frame: One month after each of doses 1 and 2. ]
- Geometric mean increase (GMI) on HI [ Time Frame: One month after each of doses 1 and 2. ]
|Study Start Date:
|October 2006
|Study Completion Date:
|May 2010
|Primary Completion Date:
|November 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: ID-JI-0.1
Group "ID-JI-0.1" (n = 16) - reduced 0.1 mL INF doses administered intradermally (ID) by needle-free jet injector (JI) (Biojector® 2000 subcutaneous syringe no. 2 [green color code], with 2 cm investigational spacer, Bioject Medical Technologies, Inc., Portland, OR, USA)
Biological: Vaxigrip® trivalent inactivated influenza vaccine
See full description elsewhere in this record.Device: Intradermal spacer on Biojector® 2000 jet injector
See elsewhere in this record for full description.
Active Comparator: IM-NS-0.1
Group "IM-NS-0.1" (n = 16) - reduced 0.1 mL INF doses administered intramuscularly (IM) needle-syringe (NS) (via 22-25 gauge needle, minimum 25 mm/1-inch length)
Biological: Vaxigrip® trivalent inactivated influenza vaccine
See full description elsewhere in this record.
Active Comparator: IM-NS-0.25 control
Group "IM-NS-0.25" (controls) (n = 16) - full 0.25 mL INF doses administered intramuscularly (IM) by needle-syringe (NS) (22-25 gauge needle, minimum 25 mm/1-inch length)
Biological: Vaxigrip® trivalent inactivated influenza vaccine
See full description elsewhere in this record.
Detailed Description:
Randomized, observer-blinded, clinical pilot (phase I) trial of safety, followed by a clinical (phase II) trial of safety and non-inferiority of immune response to the standard route and dose for the merged subjects from both phases.
Phase I - Influenza-vaccine naïve children (n = 48) aged >= 6 to < 24 months will be randomized in a 1:1:1 ratio to the following three study arms, each to receive two doses on days 0 and 28 of trivalent inactivated influenza (INF) vaccine (Vaxigrip®, Sanofi Pasteur, Lyon, France) into the left thigh (< 12 months) or left deltoid (≥ 12 months):
- Group "ID-JI-0.1" (n = 16) - reduced 0.1 mL INF doses administered intradermally (ID) by needle-free jet injector (JI) (Biojector® 2000 subcutaneous syringe no. 2 [green color code], with 2 cm investigational spacer, Bioject Medical Technologies, Inc., Portland, OR, USA)
- Group "IM-NS-0.1" (n = 16) - reduced 0.1 mL INF doses administered intramuscularly (IM) needle-syringe (NS) (via 22-25 gauge needle, minimum 25 mm/1-inch length)
- Group "IM-NS-0.25" (controls) (n = 16) - full 0.25 mL INF doses administered intramuscularly (IM) by needle-syringe (NS) (22-25 gauge needle, minimum 25 mm/1-inch length)
Phase II - Upon assessment of the safety profile from phase I by the unblinded Data Safety Monitoring Board (DSMB), with its approval an additional 402 children will be recruited and randomized (134 per group) as in phase I above. Total subjects in phase I and II = 450 (150 in each of three study arms).
Adverse Event Diaries: Parents will be trained to complete a diary form to observe, measure, and record solicited local reactions for the injection site and systemic signs and symptoms for the child for days 0 through 7 after vaccination, plus unsolicited symptoms, illness, and medications for days 0 through 28.
Followup: Return clinic visits will be scheduled on days 2, 7, and 28 after INF dose 1, at which times the diary card data will be recorded by staff and the card collected on day 28. Upon receiving dose 2 of vaccine, patients will be scheduled again to return to the study center 2, 7, and 28 days afterwards. The same procedures as for dose 1 regarding diary cards, telephone followup, and home visits will apply after dose 2.
Upon returning to clinic on day 28 after dose 2 (day 56 after dose 1), the child will receive an unblinded, "insurance", full-volume, 0.25 mL dose (#3) of influenza vaccine by NS IM, unless he or she is in the full-dose IM control group IM-NS-0.25, in which case a mock injection will be administered instead of a 3rd full dose beyond the usual 2-dose series. All participants will return 6 months after this third injection for a fourth "bonus" dose of influenza vaccine to ensure protection for the following season.
Serum Collection: Blood specimens to measure serologic responses will be collected three times, just prior to vaccination on day 0 (INF dose 1), on day 28 (INF dose 2), and on day 56 (INF "insurance" dose 3).
Ethical oversight additional to CDC IRB G by (1) World Health Organization Research Ethics Review Committee, (2) Consejo Nacional de Bioética en Salud, and (3) Fundación Dominicana de Infectología Comité de Etica/Investigaciones.
|Ages Eligible for Study:
|6 Months to 24 Months (Child)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age from > = 6 to < 24 months (not having reached 2nd birthday).
- Born after a full-term (≥ 37 weeks), and birth weight of >= 2.5 kg (>= 5 pounds, 8 ounces)
- History of prior or first attendance as a patient, or as a sibling of a patient, seeking routine immunization or other clinical care at the Hospital Infantíl Robert Reid Cabral (HIRRC)
- The parent(s) or legal guardian(s) provide(s) written informed consent and agree(s) to bring the infant back to the clinic for all visits scheduled in the study
- Up-to-date for routine doses of vaccines officially recommended for the patient's age in the Dominican Republic to prevent tuberculosis, polio, diphtheria, tetanus, pertussis, hepatitis B, and Haemophilus influenzae B
- In good health, as determined by medical history and physical examination collected in accordance with the Case Report Form (CRF), and by the clinical judgment of the investigators.
Exclusion Criteria:
Infants WHOSE PARENT(S)/LEGAL GUARDIAN(S):
- Are unable or unwilling to give written informed consent for their infant to participate in the study
- Cannot be contacted by telephone (family's own or a neighbor's) if necessary for adverse events if scheduled followup return appointments are missed
- Are unable to complete the diary for adverse events; are unable to measure and record temperatures or maximal diameter of local reactions or limb circumference; or have difficulty understanding written instructions; or other factors which indicate exclusion in the judgement of the study staff.
INFANTS who:
- Have fever (by parental report or by rectal temperature ≥ 38.5° C or axillary ≥ 38.0° C) currently or within the past 3 days, or who are currently suffering from an acute or chronic infectious disease (including known HIV)
- Have had an acute or chronic infection requiring systemic antimicrobial therapy (antibiotic or antiviral) or other prescribed treatment within the past 21 days. This includes any underlying illness that may limit their response to vaccination, such as those receiving intravenous immunoglobulin for agammaglobulinemia, or systemic steroid therapy.
- Are malnourished, defined by weight less than two standard deviations below the median weight for their age
- Are allergic to eggs, or have a history of any anaphylactic shock, asthma, urticaria, or other allergic reaction after previous vaccinations, or have allergy or hypersensitivity to any component of the study vaccine
- Have ever previously received any influenza vaccine
- Have received within the prior 28 days, or for whom there is the indication to receive in the next 56 days, any non-study vaccination or investigational agent outside of the study
- Have a known bleeding diathesis, or any condition with a prolonged bleeding time
- Currently have any serious confirmed or suspected disease, such as metabolic, cardiac, or autoimmune disease, or diabetes
- Have a history of epilepsy or a seizure disorder, or neurodevelopmental disorders such as autism
- Have a genetic anomaly or known cytogenic disorder (e.g., Down's syndrome)
- Have leukemia, lymphoma, or any other cancer/neoplasm
- Have known or suspected immune dysfunction, including HIV infection, or receives(ed) immunosuppressive therapy, including systemic corticosteroids
- Have ever received blood, blood products, or parenteral preparations of immunoglobulin
- Have any other serious disease (e.g., with signs of cardiac or renal failure), including progressive neurologic disease
- Have any condition which, in the opinion of the investigator, may interfere in the evaluation of the objectives of the study
Please refer to this study by its ClinicalTrials.gov identifier: NCT00386542
|Dominican Republic
|Hospital Infantíl Dr. Robert Reid Cabral
|Santo Domingo, Distrito Nacional, Dominican Republic, 2
|Principal Investigator:
|Bruce G Weniger, MD, MPH
|Centers for Disease Control and Prevention (email@example.com; firstname.lastname@example.com)
|Study Director:
|Virgen Gómez, MD
|Hospital Infantíl Dr. Robert Reid Cabral
|Study Director:
|Jesús M Feris Iglesias, MD
|Hospital Infantíl Dr. Robert Reid Cabral
|Study Director:
|Josefina Fernández, MD
|Hospital Infantíl Dr. Robert Reid Cabral
|Study Director:
|Pedro Moro, MD, MPH
|Immunization Safety Office, Centers for Disease Control and Prevention
|Study Chair:
|Martin Friede, PhD
|Initiative for Vaccine Research, World Health Organization
Additional Information:
|Responsible Party:
|Bruce G. Weniger, MD, MPH, Lead, Vaccine Technology, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention (CDC)
|ClinicalTrials.gov Identifier:
|NCT00386542 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 10, 2006
|Last Updated:
|June 8, 2010
Keywords provided by Centers for Disease Control and Prevention:
influenza vaccine
jet injection
intradermal injection
cutaneous vaccination
Dominican Republic
pandemic preparedness
jet injector
reduced dosage
immune response
hemagglutination inhibition
Additional relevant MeSH terms:
Influenza, Human
Orthomyxoviridae Infections
RNA Virus Infections
Virus Diseases
Respiratory Tract Infections
Respiratory Tract Diseases
Immunologic Factors
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 21, 2017


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Fuji TV announcer Yukino Kikuma resigning
Fuji TV announcer Yukino Kikuma is planning to leave the network at the end of this month, it was learned on Thursday. According to several sources, she intends to devote herself to studying law.
Kikuma has been with Fuji TV since 1995 and has received media attention for a couple of incidents. In 1998, while she was reporting on a live broadcast of "Mezamashi TV," she fell from the fifth story of a building, but fortunately suffered only a waist injury due to some safety precautions that had been taken.
Sankei Sports

subset: commoncrawl


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text:
PRZOOM - /newswire/ -
New York, NY, United States, 2011/03/08 - The solution is the latest in a series of online legal research innovations from LexisNexis that help legal professionals drive better outcomes for their business and their clients (NYSE: ENL; NYSE: RUK).
LexisNexis, a leading global provider of content-enabled workflow solutions, today announced Lexis Advance for Associates will be the next tool released on the companys New Lexis technology platform.
Lexis Advance for Associates is the continuation of our strategy to provide professionals with tools that are specifically designed for them, said Bob Romeo, chief executive officer of Research and Litigation Solutions at LexisNexis. Through close collaboration with our customers across all sectors of the legal industry, we know those who routinely conduct legal research want new innovations to help them build their expertise to become even more valuable to their organizations, so they are more efficient and better organized, and to demonstrate their ability to drive better outcomes for their own clients.
Lexis Advance for Associates is aimed at serving primary users of online legal research such as associates at law firms and staff attorneys at corporations and in government. Core elements of the product deliver a number of easy to use features for them, including an intuitive single search interface that eliminates the need to select sources before searching and cuts out multiple steps in the search process. It also offers users the control to find relevant search results faster and more confidently with pre- and post- search filters. Furthermore, work folders allow for easy storage and access to previous work.
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text:
Quantitative Imaging Workshop IX will take place October 2-3, 2017 at the Hilton McLean Tysons Corner.
Since 2003, the Prevent Cancer Foundation has hosted a series of annual Workshops focused on the application of high resolution CT imaging data to lung cancer, COPD, and cardiovascular disease. Future workshops will continue to provide a forum for an exchange of ideas on the application of quantitative CT imaging to early disease management as well as for discussing policy and advocacy for lung cancer, COPD, and cardiovascular screening done responsibly.
For more information, contact email@example.com
Quantitative Imaging Workshop XIII: Lung Cancer, COPD and Cardiovascular Disease – Exploring the Intersections took place June 13 & 14 at the Bethesda Marriott Hotel in Bethesda, Maryland.
Press Release on Results of 2016 Workshop.


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Neoliberalism. Seldom throughout history has a single word held such drastic ramifications for the people of the world, while remaining relatively unknown and unused by the general population.
Certainly not to be confused with social liberalism — in fact, most people who consider themselves "liberals" in the general sense will find themselves staunchly opposed to the neoliberal doctrine — neoliberalism refers to the prevailing economic policies of the last 30 years, policies that, while providing unprecedented wealth concentrated in the hands of policymakers, have worked to promote social and economic inequality, increase deprivation for the poorest nations, and put the earth on a fast track toward environmental catastrophe.
Originally associated with Reagan and Thatcher, during the past three decades neoliberalism has dominated as the global political economic trend supported by parties on either side of the aisle, forming a "Washington consensus" of sorts. The concept is relatively simple: Laissez-faire liberalism is not enough. Modern economic policy is required to produce truly efficient markets; private interests should be able to control as much of society as possible in order to maximize profits, increase competition and consequently benefit society as a whole. Thus, neoliberalism.
But in reality, neoliberalism benefits a small portion of society. While it is true neoliberal policies generally promote economic growth, it is often to the exclusive benefit of financial institutions and private interests and at the tyrannical expense of the poor, the working class and the environment.
The abjections of the poor and working class in the developing world are documented and understood well enough in our society that they do not warrant extensive reflection. It's pretty much common knowledge multinational corporations exploit labor in the developing world. Most people I know think this is abhorrent but accept it as "just the way things are."
There's some truth in that. These uncivilized practices are simply the byproduct of our neoliberal political economic system, a system that places profit on a pedestal and regulations on the curb.
It's important to note how this systemically impedes any environmental progress. According to neoliberal theory, since profit-making is the essence of democracy, any governmental procedure that limits markets is undemocratic and must be done away with. Armed with this backward logic, private interests are thus rationalized when they fight to end environmental regulation. That trashes our world all in the name of profit, lest the government intervenes and behaves "undemocratically."
Deeply embedded in neoliberalism, this perverse understanding of democracy is especially troubling when one sees Americans are beginning to wake up from their environmental apathy. The numbers are rising: Poll after poll shows Americans are realizing our environment is in bad shape, man-made global warming is largely the cause and carbon emissions should be regulated by the federal government.
The people have spoken.
And what's more still, earlier this week, climate scientists at Manchester's Tyndall Centre for Climate Change Research released commentary about the issue of climate change aversion within our orthodox political economic paradigm. The researchers concluded avoiding climate chaos in our lifetimes is "wildly unlikely" as long as economic growth is valued above all else as the essence of neoliberal political economic policy.
Taking all this into account, anyone concerned about the current state of our environment and the direction in which it's headed should first understand the fundamental paradigm that our economy operates within, and how substantial environmental legislation isn't going to be enacted while such systemic inefficiencies stand in the way.
In the fight for a sustainable future, we must not forget private interests are not accountable to the public like the government is. We as citizens, through direct action or otherwise, have to fight to bring the faults of neoliberalism into public debate and address these central problems facing our environment and our nation.


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Italian sculptor Venanzo Crocetti (1913-2003) is best known for his figures cast in bronze, and in particular for his bronze relief "The Door of Sacraments" at St. Peter's Basilica in the Vatican.
Next year will be the centenary of Crocetti's birth, and to celebrate his life and career, The Hakone Open-Air Museum is exhibiting 33 of his works, including bronze pieces and some of the artist's chalk drawings.
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Friarage battle - downgrade to finally go ahead
4:55pm Wednesday 28th May 2014
4:55pm Wednesday 28th May 2014
A FRESH legal battle could be looming over the future of maternity and children's services at one of the region's leading hospitals.
Local health bosses were today, May 28, given the go-ahead to downgrade the services at the Friarage Hospital in Northallerton by Health Secretary Jeremy Hunt.
His decision followed advice from the Independent Reconfiguration Panel which ruled out a full review and said the changes were in "the best interests of local woman and children."
The development was met with outrage by campaigners, led by Richmondshire councillor John Blackie who labelled it "incredibly disappointing."
He said they would now be going back to their legal advisers to look again into the possibility of mounting a judicial review of the "flawed" decision-making process.
"It is our last chance saloon," he said. "If there is a case we can take forward – and if we can afford it – we will."
The Hambleton, Richmondshire and Whitby Clinical Commissioning Group first came up with the proposal almost three years ago and it led to a storm of protest.
Even Richmondshire MP William Hague sided with the campaigners, leading a protest march through the streets of Northallerton.
But the IRP has finally decided in the CCG's favour, with chairman Lord Ribeiro saying: "The quality of patient care has been our primary concern and after considering the matter carefully we believe these changes will ensure the best care for local women and children.
"We have taken into account the clinical evidence about the current and future safety and sustainability of maternity services and the need to make best use of scarce resources, and believe these proposals are the most effective way of meeting the challenges currently facing the Friarage Hospital."
The CCG's chief clinical officer Dr Vicky Pleydell welcomed the decision and said the new services would be implemented from October this year.
"We hope that people who have had concerns about these plans will be reassured by the Secretary of State's decision based on independent clinical advice, and are now confident that this is absolutely the right thing to do," she said.
"This change is supported by all of the local doctors and midwives and we know this will provide safer, better services for local mothers and children which will last into the future."
The changes will see the Friarage downgrading to midwife-led maternity care and short-stay paediatric assessment services with a consultant-led maternity service provided by Middlesbrough's James Cook University Hospital and other neighbouring hospitals.
© Copyright 2001-2017 Newsquest Media Group


text:
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text:
While many people consider the 1993 movie "Groundhog Day" to be little more than another sample of Bill Murray's comedic talent, Paul Hannam is among those who looked past the film's humor to find deeper meaning.
"'Groundhog Day' is a very powerful parable abut how we're stuck in loops," Hannam said. "What really struck me about this movie is it's about stripping away everything in this man's life 'til you get to the essence. When it's all stripped away, all that's left is the beauty of being a human person."
The movie's unlikely hero, weatherman Phil Connors, finds himself waking up to the same day over and over. As everything of import in his life is stripped away and each day repeats itself, Connors realizes the only thing he can change is his own thinking and actions. That change results in him finding happiness.
"The question for me," Hannam said, "is how can somebody change the worst day of their life to the best day in their life without changing anything but their way of thinking."
Using the movie as a framework, Hannam has written a book called "The Magic of Groundhog Day," (Waterside Press, $21.95) which demonstrates how people have the power to change their thoughts, emotions and attitudes to break out of self-defeating behaviors and transform their lives.
"It's about waking up," he said. "It's about building a life not on what money can buy but what it can't buy.
Hannam's book explores the themes of acceptance, love, creativity, awareness and understanding what holds people back. He encourages people to ask the question, "What one action am I going to do today to move me to a better life?"
There are many trends nowadays, said Hannam, that illustrate a desire to find meaning in life, to slow down and simplify, and to change how people are living and the way it impacts Mother Earth.
"I think there's a deep yearning for change," he said.
Hannam immigrated to Rancho Santa Fe with his wife Sue and their son and daughter in March 2007.
"I've been coming here for nearly 30 years," said the British native. "Another big factor for me is the career opportunity."
Having built a successful career in environmentalism in Europe, Hannam felt it was the perfect time for him to bring that experience to the U.S. He has worked in both the business arena and academia, a unique combination which gives him insight into industry and science.
"The fact is, we all have to work together," he said.
At 28, Hannam started his first company. Since then he has been involved in several start-ups, including his most recent undertakings: Bright Green Talent, Greenest Host and Enso Ventures.
Bright Green Talent is an executive search firm with offices in London, San Francisco and, soon, Brussels. The company recruits the best and the brightest to work for organizations committed to sustainability and corporate/social responsibility.
In 2007, Hannam became chairman and co-owner of Greenest Host, which provides eco-friendly web hosting service and consultations.
In January, Hannam and Charlie O'Malley started Enso Ventures, an "incubator" for green businesses.
One recent study indicated that one in four new jobs in the next 20 years will be in the environmental sector. A part of the global awareness trend in Europe, Hannam said he sees enormous potential in the U.S.
"We have to be thinking very carefully about the environment to protect our quality of life," he said, adding that every aspect of life – home, family, work, travel – is going to dramatically change in the next 50 years because of environmental factors. "For me, my main mission is to create a new generation of leaders through my teaching and writing. You can become interested in 'green' for may reasons. A lot of people are becoming interested now because they're just fed up. This is not what living should be about."


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Nats draft pick sends offensive tweets
A Nationals shortstop draft pick has made offensive comments on his twitter account, sparking a deletion of the account and an investigation by the team.
Zach Houchins, 18, picked in the 15th round of the amateur draft, made derogatory comments against African Americans and others, according to the Washington Post.
Nats blog For the Love of the Nationals posted Houchins' insightful thoughts on Wednesday. The mainstream press discovered it this morning.
"We are aware of and investigating the comments," General Manager Mike Rizzo said in a statement, the Post reports. Houchins' twitter account was deleted.


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You are not permitted to download, save or email this image. Visit image gallery to purchase the image.
The allegations have cast a cloud over Australia's richest and most celebrated thoroughbred race, with pundits slamming administrators for allowing the jockey, a former Melbourne Cup winner, to ride today.
Oliver, who won the 2002 race on Media Puzzle, had admitted to racing stewards that he had placed an $A10,000 bet on Miss Octopussy in a local race two years ago in which he rode another horse, Fairfax Media reported, citing unnamed sources close to the jockey.
Stewards revealed last month that they had been investigating Oliver over the illegal bet.
Oliver, 40, has declined to comment on the allegations directly, but said last month that he was entitled to "due process."
His manager Mark Van Triet declined to comment on the allegations when contacted by Reuters today, but confirmed Oliver would ride Americain.
"It's business as usual," he said by telephone.
Governing body Racing Victoria (RV) was not able to immediately provide comment when contacted.
Fairfax quoted RV chief Rob Hines as saying the investigation into Oliver would be finalised in the "next week or so", effectively after the state's major racing carnival wraps up.
Americain, trained by Frenchman Alain de Royer-Dupre and the winner of the 2010 Melbourne Cup, is rated favourite or second favourite behind another French stayer and last year's winner in Dunaden.
Americain's owner Gerry Harvey said he and connections had not considered changing riders for today's race, despite knowing the betting storm would break.
"We believe this is the right decision," Harvey was quoted by Fairfax as saying.
The allegations against Oliver are part of a wider investigation into corruption in horse racing in the southern state of Victoria.
Local media have reported that at least two other jockeys riding in the Melbourne Cup are under investigation.
Victoria's racing minister Denis Napthine backed authorities to ensure the race would be run with integrity.
"People can have confidence that racing today at Melbourne Cup day will be fair, reasonable and they can have a bet with confidence," he told reporters in Melbourne.
Pundits have blamed government officials for failing to provide racing administrators the powers to stand down jockeys and other racing personnel under suspicion of corruption.
"Who knows what is yet to come to light?" a commentary in the Age newspaper said. "And yet those suspected of corruption ... can keep on keeping on during Australia's premier racing event as if nothing has happened. What a disgrace."


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Cai, Xiao Xiao (2010) Characterizing the influence of neutron fields in causing single-event effects using portable detectors. Doctoral thesis, University of Central Lancashire.
PDF (eThesis)
- Accepted Version
Available under License Creative Commons Attribution Non-commercial Share Alike.
The malfunction of semiconductor devices caused by cosmic rays is known as Single Event Effects(SEEs).
In the atmosphere, secondary neutrons are the dominant particles causing this effect. The neutron flux density in atmosphere is very low. For a good statistical certainty, millions of device hours are required to measure the event rate of a device in the natural environment. Event rates obtained in such testings are accurate.
To reduce the cost and time of getting the event rate, a device is normally taken to artificial accelerated neutron beams to measure its sensitivity to neutrons. Comparing the flux density of the beam and the flux density of a location in the atmosphere, the real time event rate can be predicted by the event rate obtained. This testing method was standardized as the neutron accelerated soft error rate (ASER) testing in JEDEC JESD89A standard.
However, several life testings indicated that the neutron flux density predictions given by the accelerated testings can have large errors. Up to a factor of 2 discrepancy was reported in the literature. One of the major error sources is the equivalence of the absolute neutron flux density in the atmosphere and in accelerated beam.
This thesis proposes an alternative accelerated method of predicting the real-time neutron error rate by using proxy devices. This method can avoid the error introduced by the uncertainty in the neutron flux density.
The Imaging Single Event Effect Monitor (ISEEM) is one of the proxy devices. It is the instrument originally developed by Z. Török and his co-workers in the University of Central Lancashire. A CCD was used as the sensitive element to detect neutrons. A large amount of data sets acquired by Török were used in this work. A re-engineered ISEEM has been developed in this work to improve ISEEM performance in life testings. Theoretical models have been developed to analyze the response of ISEEM in a wide range of neutron facilities and natural environment. The agreement of the measured and calculated cross-sections are within the error quoted by facilities. Because of the alpha contamination and primary proton direct ionization effects, performance of ISEEM in life testings appeared to be weak.
|Item Type:
|Thesis (Doctoral)
|Additional Information:
|helen/hayley please check
|Uncontrolled Keywords (separate with ;):
|Neutron detector, single event effect
|Physical sciences > Physics
|Faculty of Science and Technology > School of Physical Sciences and Computing
|ID Code:
|Deposited By:
|Khalil Ahmed Patel
|Deposited On:
|07 Mar 2011 15:50
|Last Modified:
|17 May 2016 12:21
Repository Staff Only: item control page


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Don't read if you are offended with rape and abuse. Contains events that will be quite offensive and possibly "disgusting". You have been warned.
Runner Up in the Dangerous Liaisons Awards and He Had It Coming Awards.
~The story is now Complete!~
Thanks for reading!
Um i wanna no this:
How cum whenever characters have sex in fanfiction without protection they dont get preganant???? is there sum secret charm or sumthin
Gawd Draco is such an ass why doesnt he just go screw Pansy or Millicent
Wow. U should become an author. A REAL author. If you did im sure youd get all your books turned into bestsellers for sure!
Awwww. I know you probably didn't mean for the story to be kind of fluffy but I couldn't help it. Just the way you described Ron and Hermione's affection toward their daughter is urging me to have some children of my own!
Umm...This may seem like a really stupid question but I need to ask it...Was Ron liking Draco before, or just then? And was Draco liking Ron before, or just then?
Dammit Dean is a slimy git and he should just go prance back to the friggin' forest and be the Wolf again and go eat granny
AVADA KEDAVRA! *Phimie drops dead* Hehehe...
Harry leaned in close so he could whisper into her ear, I can make you scream it.""
Man You make harry sound so freakin' hot!! Especially the way you describe his kisses. Uhjhhhh!!! HE'S SOOOO HOT!!!
Holy Crap that was freakin' awesome!
Dammit! I want more NOW!! And umm..just one question...WHERE IS THE SEX?!? LOL but will there be any sexual scenes in your story?
Holy Crap
Perfect soundtrack to this amazing story:
Seventeen Forever by Metro Station
Hell-to-the-YEAH! I don't mean to sound like some sort of sex-starved perv or something but I love these kinds of stories that give a crapload of detail!!
Graceful one you are, James joked, trying to keep himself from thinking about her lovely bum.
Hahaha! Loved that!
Author's Response: Haha. I liked that part too. :-D thanks for reviewing!
This is kinda confusirating me.
Author's Response: hmm well this chapter was supposed to be a little mysterious ... the next few chapters will clear everything up, hopefully. :)
Confusing + Infuriating =Confusirating
Author's Response: ha i was wondering about that ... thank you for explaining. ;)
Gawd that was awesome! But I'm so TO'ed at Ron. He's my man! Just Kidding. Awesome-est story ev-ah!
Wowwie-Ka-zowie! PUT THE NEXT CHAPTERS UP NOW!!!!
Wowwie-Ka-zowie! PUT THE NEXT CHAPTERS UP NOW!!!!


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About this Vendor
Local, Regional & Destination Wedding Photography
We hope you've found some images that are enjoyable and even captivating. ACP loves the challenge of capturing the perfect image, whether it be your long-awaited wedding day, your growing family or the majesty of a stunning landscape. We love what we do, and we want to help tell your story. Our journalistic approach attempts to capture the the celebration and atmosphere of your story with heirloom images to be enjoyed for years to come. We've traveled much of the US with camera in hand, including weddings in a handful of states, and we have had work published both locally and nationally. Our goal is simple: We want to chronicle your love story and equip you with a product that you will love for years - and we think the process should be enjoyable. Let's chat :)
Artistic, Documentary, Lifestyle, Modern, Vintage
Bridal Portraits, Day After Session, Engagement, Trash The Dress
Getting Engaged, Wedding
Destination Wedding Packages, Destination Weddings, Online Proofing, Digital Files, Printed Enlargements, Wedding Albums, Photo, Second Shooter Available, Social Media Sharing, Photo + Video
Contact Info
I was overwhelmed at the initial stages of searching for a wedding photographer. To top it off, I was having an out of town wedding, I'm quite the perfectionist, and my now husband has a fake picture smile (don't tell him I said that). What a joy and relief it was to find Aaron... Read More Clark! I have never met a photographer more accommodating, receptive, professional, talented, responsive, nor as organized as Aaron. He was a true blessing to our day. The product was fantastic and was delivered to us in a timely manner. Because of him, we were able to relax and enjoy the day of our wedding. Thank you Aaron!
Kylie, I'm so happy that I was able to help you two enjoy your wedding day. I really enjoyed working with you two and your families :)
Best Photographer YetReviewed on 10/07/2014
I could never imagine a better photographer! From the moment I met him I knew he was going to be the best person I could've chose for our engagement and wedding. He was absolutely outstanding and never made it awkward during pictures, always knew exactly what to do to make us... Read More smile, none of those fake looking pictures. I will have Aaron as our photographer for life. His pictures were real and I'm obsessed with looking at them every time I see them. I would recommend him to anyone wanting the best photos for your big day not matter what the occasion.
Thank you! I'm looking forward to working with you again!
Great photographer who made taking pictures a blast!Reviewed on 11/06/2013 Ashley T
Aaron was reccomended to me from the Chapel owner where we were getting married. So I emailed him about doing my pictures and in less than 10 min he responded to me. Every question I had he would respond right away. That's when I knew he was good. (Also, he has a great website)... Read More I have a pretty tough family when it come to taking pictures but Aaron had us all laughing and having a great time. Before we knew it pictures were over. He took every combination of pictures along with many creative ones of his own. I would reccomend Aaron Clark Photography to anyone looking for a skilled, dependable, and fun photographer. Because honestly, real smiles in photos look much better than fake ones! That's what Aaron can do!
Love it! Thanks for the kind words!
We had the best experience with Aaron Clark Photography! Soon after our engagement, we contacted Aaron to photograph our wedding. He was booked on our big day, but quickly offered his assistant, Allison Matthews! Aaron showed us Allison's beautiful portfolio and was very... Read More confident in her skills as a photographer. We trusted Aaron and hired Allison. Quickly, we saw why Aaron had Allison as his assistant; she was wonderful! Allison was fun to work with and took beautiful engagement/ wedding pictures for us. Aaron was still very involved in the process, including editing our pictures. We highly recommend Aaron Clark Photography!
When I was planning my wedding I knew the photos had to be the most important part. I allotted the most of my budget to my photos and I was the most picky about how they looked and the style I wanted. I wanted nothing short of perfection. I had a couple friends in the wedding... Read More biz suggest Aaron and when I got a hold of him he was just leaving from talking to another couple who had our same wedding date. Luckily it didn't work out for them because a few days later we booked Aaron. Aaron is awesome. He's so laid back. He's fun, he's funny and you actually feel like he's just a super fun guest at your wedding. We did our engagement shots with him as well, my hubby and I live in Florida so we flew up just to do our engagement shots with Aaron. Totally worth it! The photos were amazing. Despite living in Florida we did have our wedding in Missouri. Aaron was awesome about answering emails every time I had a question, which was quite often. Despite changing things a dozen times he totally went with the flow and was right there when we needed him on the wedding day. His pictures are amazing. Even the details he puts in when he sends the CDs with the picture files on them is amazing. I couldn't have had a better photographer. If you're looking for an amazing photographer who also happen s to be one of the coolest people you've ever met then Aaron is your guy. If you can book him do it. In fact, I wouldn't even pick your wedding date until you're sure that he's available. Thank you Aaron.
Wow, this is an incredible review! Thank you SO much Jes!
Aaron was absolutely awesome to work with! He made our engagement pictures and wedding pics so much fun! I even had compliments on how friendly and fun he was from my family members and friends. He was also quick to give us our pics and video. I would definitely recommend using... Read More him, our pictures came out fabulous! We have had so many compliments on them! You won't regret your decision to use his photography services.
Thanks Jessica! You guys were so much fun to work with. Thanks for letting us work for you :)
We knew a wedding photographer was important for our big day and we were blown away by Aaron Clark. He made us feel comfortable throughout the engagement session and the wedding. We were very impressed with the picture quality and variety of photos. Aaron was efficient, fun,... Read More affordable, and excellent at managing time. I am so glad we picked him as our photographer and I can't think of a single thing I would change about our pictures!
I love it! So glad that there's nothing you would change!!
You can't ask for a better photographer! My husband and I met Aaron two years before our wedding. We had just gotten engaged and were taking a summer trip to Branson. We wanted to get our engagement photos done at Big Cedar. We found Aaron off the knot, and met up with him. We... Read More are not picture people but Aaron had such a way with making us feel so comfortable in front of a camera! It felt like we were all just hanging out and having a great time. In fact we ended up liking Aaron and his way with taking photos so much that we asked him to travel to our wedding in St. Louis. Aaron was so responsive to any emails that he was sent. He followed up with us before the wedding just to confirm he had everything correct for timing and location. We spent about 30 minutes on the phone with him going through the timeline of the day. Leading up to the big day a bride can get pretty nervous! Out of all of our vendors, Aaron was the one who never even crossed my mind to worry about! I had the highest level of confidence in him. He didn't disappoint. Aaron had such a way with making everyone laugh and feel comfortable during photos. It was extremely hot during our outdoor wedding in June. He was able to take the photos and keep everyone comfortable and smiling at the same time. He captured so many beautiful photos. I couldn't have even imagined how many beautiful shots he would get! We received so many compliments on how great our photos are as well as Aaron's personality! Everyone was talking about how great he was, and how funny his jokes are! We received our photos super quickly! We will continue to use Aaron as our photographer for our future photos!
Thanks Mike and Tiffany! So glad I could make the photo experience fun for you guys and help keep your wedding planning stress-free. Hope to see you guys again!
Aaron Clark did all the photos for our wedding, my wife and I had nothing but a phenomenal experience from beginning to end! We had tossed around the idea of trying to save money by using a relative or friend, but with that you don't get the professionalism, the quality or the... Read More craftsmanship that Aaron can do with your photos for the most important day of your life. After we got our pictures back we knew that we had made the right decision is using him! We will always recommend him to all of our friends. He was very easy to work with while taking the pictures and he kept our best interests in mind the entire time, capturing what really meant to us during the photo shoots. Great guy, super professional and 5 starts all the way!
Thanks for the kind words, Ethan! So glad I could help make your wedding day smooth.
First off, Aaron is truly an honor to work with and couldn't ask for anyone better to capture our day! We had got engaged and took a vacation to Branson and we set out to find someone to do our engagement session at Big Cedar Lodge. I ran across Aaron on the Knot and got in... Read More contact with him and in no time we had him taking our photos out there! We were very much impressed with his work ethic as well as him as a person. He was very easy to get along with as well as always keeping everyone focused! We decided he was the man we wanted to photograph out wedding back home in St. Louis! Needless to say he made it happen and we are beyond pleased to have chosen him. His work is top notch along with great communication from start to finish. Turn around time was extremely fast as well! I definitely recommend him to be the guy behind the lens to capture your special occasion no matter what the case may be!
Thanks Mike! I really had a great time working with you two!
Aaron was awesome to work with! My hubby wasn't exactly thrilled for the picture part of the day but Aaron even managed to get him to enjoy it! He's funny and makes you feel comfortable, he listens if there are certain pictures that you want or if you pass by somewhere that you... Read More want a picture. We got married at Dogwood Canyon and our pictures were just gorgeous!!! I highly recommend Aaron Clark!
Thanks Brooke! Glad I could contribute to a fun day for you two :)
Enough cannot be said about Aaron Clark. From day one he was beyond helpful, professional and personable. Trying to plan a wedding from Alaska was definitely a harder task than we thought and Aaron was willing to help anyway he could. When taking pictures we had fun and felt... Read More completely comfortable around him. His jokes and carefree personality made family and friends enjoy the night even more. If you are looking for someone who is very detail oriented and looks for unique images, we would recommend Aaron. His photos were beyond anything my husband and I could have imagined and we can not wait to have him capture other precious moments in our lives.
Wow, thanks so much! Glad I could be part of the celebration :)
Aaron gave us exactly what we wanted and more. He did such an exceptional job on our engagements and wedding photos. He always worked with us on anything we needed and he made this part of the wedding planning a breeze. He knows how to make you comfortable and relaxed on the big... Read More day as well as during all the photos. My husband and I are so content with our entire expirience.
So glad I could help make your wedding a great experience!
Aaron did our engagement photos and he is so personable and makes it so much fun! He makes everyone so comfortable with his great personality. The photos are amazing to top it off!
Thanks guys :)
We loved working with Aaron! He is a very talented photographer that captured the joy, laughter and most important moments of our wedding. He's positive and professional approach kept our family and bridal party relaxed and captured some beautiful expressions and moments. My... Read More husband and I were blown away by the photos and video. I highly recommend Aaron to every bride and groom.
Thank you Stacey!
Aaron took pictures with us in Branson MO. From engagement pictures to the wedding day pictures, Aaron was so much fun to work with! He made Tim and I feel so comfortable that at times we forgot he was there! My engagement pictures turned out so beautifully that I couldn't wait... Read More to see how my wedding pictures would turn out. I would highly recommend Aaron as a wedding photographer.
Thank you Meredith!
Awesome photographyReviewed on 8/22/2015
Aaron does awesome photography and has a way of making you feel very relaxed. He takes request well. He did not know how to pin on corsages. He has great communication skills. He makes you feel like you are the only wedding party he is taking care of. Overall very satisfied with... Read More his work I would highly recommend him.
Haha! It's true, I'm no good at pinning on corsages. Thank you for the kind words and for letting me be part of the big day. Had lot's of fun with you guys.
I recommend Aaron Clark Photography to anyone! I loved how his packages included all engagement session and wedding session photos at a very reasonable price. His talent and creative eye allows for photos to be unique and beautiful. He sees beauty in things most people overlook.... Read More His professionalism and fun personality were commented on by many wedding guests. Aaron made a fun and personal connection with many family members and guests allowing for photos to be fun and it intimate. Another thing many commented on was how Aaron didn't waste time taking the same shot over and over. He could stage photos quickly and get just the shot he wanted quickly. Our wedding wouldn't have been the same without him! The tough part is deciding which photos are your favorites!
Hey I enjoyed being a part of your wedding day! Thanks for the chance to work with you and capture the memories!
Aaron Clark PhotographyReviewed on 8/21/2015
Aaron did a fantastic job photographing all of the aspects of our wedding. Every detail, decoration, and moment was captured perfectly. Aaron's ability to talk to anyone like an old friend and his cool demeanor made the photo sessions go smoothly and was fun which showed in the... Read More pictures. Aaron was also very attentive and responded to emails, quickly answering any questions we had. We are beyond happy with Aaron's service and photos and would highly recommend him for any occasion.
Thank you! I'm thrilled that I had the opportunity to work with you folks.
Perfectly Captured Lifetime MemoriesReviewed on 6/18/2015 Chelsea V
We were extremely impressed with Aaron Clark and his photography service! He was friendly, easy to work with, organized, provided great insight and advice to help us ensure we got the pictures we wanted, and we didn't have to wait forever to see our photos after the wedding... Read More shoot! He is gifted, he captured truly who we are as a couple, and made orchestrating family and extended family photos virtually seamless! We give him all 5-star ratings because he deserves them! Thanks, Aaron!
Thank you so much Chelsea! We enjoyed being part of the celebration.
I can't imagine a better person to photograph our big day. Not only did he capture every moment but he added so much fun to the day. After receiving our pictures and family and friend got to view them they told us how they "just sat down and relived one of the best days of their... Read More lives." Aaron also did a wonderful job with our engagement photos making sure our personalities came through!
Thank you for the kind words Ashton! You guys made my job easy!
Aaron Clark is the most amazing photographer you will ever find! Not only is he professional and fabulous at what he does, he is so much fun! He made us feel at ease from the moment we met him. Our wedding party absolutely fell in love with Aaron and the local ones plan to... Read More book him for family pics. Aaron took time to get to know us and then selected sites that matched our personalities. Not only did he have great insight as to what types of poses we wanted, but he let us have some creative input as well. We told him during our engagement session and again at our reception, "We have found our photographer for life!" Aaron Clark is the absolute best ever!!!
Thank you Ashley! I had a blast working with you guys :)
Awesome Job of Capturing the Emotions of their Special Day!!Reviewed on 2/04/2015
Aaron of Aaron Clark Photography did an EXCELLENT job of capturing all the special moments! It was a very emotional ceremony, and he captured it all!! Just AMAZING!! Not for sure how he did it, except that he is VERY talented, and has a great EYE for uniqueness! The bride... Read More didn't want "traditional", so I was curious how he would be able to please her, and he exceeded her expectations! Aaron was easy to work with along with being flexible. After looking through the pictures, it was as if I was looking at the wedding all over again! Thank you Aaron for a job well done!!
This wedding was such an incredible day to be part of. Thank you for having me!
Best Wedding Photog in Southern Missouri!!Reviewed on 11/05/2014 Ashlen S
A month ago we used Aaron to photograph our wedding, and we could not have made a better decision. Here are all of the reasons you should use Aaron Clark: - He genuinely cares and listens to what the bride does/does not want - He takes the time to sit down and learn about the... Read More couple and their style - He likes to do engagement sessions before so the couple feels more comfortable the day of - He communicates very well and timely - He is priced right and the photos are beautiful!!! I would be hard pressed to say there is a more personable photographer in Southern Missouri. He directs and makes everyone feel at ease and is funny at the same time! After the wedding the first thing after a congrats from our guests was how much they loved the photographer!! You can't go wrong with Aaron!
Thank you so much Ashlen! Your wedding was tons of fun to be part of. Thank you for the kind words!
Great photographerReviewed on 11/04/2014 Amber S
Aaron is an amazing person, very friendly, funny, and energetic. He was wonderful at responding to questions quickly and did his best to make us comfortable in front of the camera. All of our family and guests loved him. I do recommend getting as much time as possible within... Read More your budget as I wish we could have had more time and more pictures. He got our pictures back to us well within the promised time which was extremely quick. Our engagement session was included which was a very nice bonus and he did send us CDs with releases for all of our pictures which is awesome. I would definitely recommend Aaron!
Meet The Owner
Aaron Clark Photography was born in the passion of capturing the beauty moments in the world around us. We love what we do, and we want to help tell your story. ACP is based out of Springfield, Missouri, but we greatly enjoy the adventure of meeting new people and finding new places to capture blossoming love stories. We want to chronicle your story and equip you with a product that you will love for years - and we think the process should be enjoyable. ACP strives to provide high quality imagery in a blend of candid journalism and timeless imagery.


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WASHINGTON (Jan. 6)
The joint United States-Israel desalination board began today discussion of final aspects of the feasibility study which envisages the operation in Israel by 1972 of a dual-purpose, nuclear-powered desalting plant. Discussions concern the approval of the final report of the feasibility study and recommendations for implementation. The board findings will be presented to the two governments within a fortnight, it is believed.
The board is thought likely to continue in existence even after the approval of the desalinating project to act as a liaison agency between the United States and Israel on desalination. The study was made by the Kaiser-Catalytic Co., of Philadelphia. A phase of the current meeting took place today in that city. Israeli delegates participating in the deliberations are Gen. Zvi Zur, chief coordinator of the Israeli Desalination Program; Aron Weiner, head of Tahal, the Israeli Government water planning authority; and Prof, Shimon Yiftach, of the Israel Atomic Energy Commission.


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Economies of scale and other benefits that will come with the joining of iTradeNetwork and FoodLink will begin to gain sharper focus over the next few months, a company official said in early August.
"We are in the process of putting the two companies together to really go after the food market for supply chain information and technology," said Kevin Brooks, senior vice president of marketing for iTradeNetwork Inc.
Brooks said the company will have a large presence at the Produce Marketing Association's Fresh Summit in October and will discuss more details how the company will serve the produce industry.
iTradeNetwork's order management and procurement services are used by retailers, foodservice distributors to place orders with suppliers and electronically manage purchase order and information flow, he said.
Brooks said with the combined retail buying networks of FoodLink and iTradeNetwork account for a majority of retail food purchases in North America, including produce, meat, seafood and floral, using the comany's services.
In early July, Pleasonton, Calif.-based iTradeNetwork's parent company Roper Industries bought FoodLink Holdings; the combined company will be merged and branded as iTradeNetwork.
The combined company labels and tracks 10% of all shipped cases of fresh produce in the U.S., and more than 100 million produce items each year feature FoodLink quick-response codes and item-specific consumer labels in stores, according to an iTradeNetwork fact sheet.
Brooks said the company may add momentum to the Produce Traceability Initiative.
According to the fact sheet, the combined companies will improve order management. Other benefits to retailers will include enhanced visibility to more of the food chain and food safety and merchandising solutions. according to the company.
For grower/shippers, the company provides a single platform for traceability, and simplified order and inventory management, according to the company.
The company has offices in Germany, the United Kingdom, Australia, New Zealand and India.
The company also is involved in Global Data Synchronisation Network data pool efforts, he said.
iTradeNetwork has an annual customer conference in January, at which Brooks said a comprehensive picture of the combined companies services will be given released.


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This photo is of :Orville and Julia (Henderlight) Davis BRANDON. This picture was taken somewhere between 1855 and 1861. They were living in Rogersville Hawkins Co TN in 1861 when their only son, J. J. (John Jefferson) BRANDON was born. They also had 3 daughters, Sarah ("Suds"), Mary Jane, and Orvillia who may have been born after J. J. It is not known when they came to Rogersville. Orville served in the Civil War, and it is assumed he died during the war (he died of pneumonia). Julia married again. Her 1st marriage was to Albert Davis who was killed by lightning. Her third marriage was to Cal Helton.
This photo was submitted by:


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Politicians to debate CSCOPE this month
By from Staff Reports
Aug. 8, 2013 at 11 p.m.
Two Texas politicians at the forefront of the battle over CSCOPE have agreed to a public debate in Tyler later this month though the two have not agreed on the format or venue.
State Sen. Dan Patrick, R-Houston and Thomas Ratliff, vice-chairman of the State Board of Education, embody the dispute over the curriculum program in use since 2006, which became a political issue during the 83rd Legislature pitting hundreds of school districts against social conservatives and tea party groups.
Patrick, chairman of the Senate Education Committee, almost single-handedly crippled CSCOPE by getting the Education Service Center to agree to stop using the lesson plans on Aug. 31, sending some 800 Texas school districts scrambling to develop alternate activities tied to the state's intricate standards.
Ratliff, elected to the SBOE in 2010, has called Patrick a bully who is using the CSCOPE issue to catapult his political career.
Patrick - who has said he would debate anyone any day on CSCOPE - agreed to debate
Ratliff Aug. 24 in Tyler at an event hosted by Grassroots Ameria, We the People at Lakeview Church of the Nazarene.
Ratliff said Thursday he preferred another venue.
"First and foremost, I'm in," the Mount Pleasant moderate Republican said in a release Thursday. "I look forward to a thoughtful and detailed policy discussion/debate with Senator Patrick, not an exchange of sound bites with candidate Patrick."
Ratliff proposed a debate at UT Tyler Ornelas Hall utilizing a three-person panel of questioners to include Mary Ann Whiteker, Superintendent of Hudson ISD, Scott Braddock, of the Quorum Report as moderator and JoAnn Fleming representing Grassroots America, We The People.
A Patrick campaign news release said the event would follow the Texas Tribune's well-known 'conversation' style to allow a more unstructured, free flowing exchange of ideas."
Ratliff said he agreed the issue needs a "free flowing exchange of ideas" but he wanted it in a different venue.
"I'm proposing a change of venue because I want to remind everyone this should be a discussion about education policy, not a campaign rally. I also intend to invite area schools' debate students so they can have the opportunity to see a "real world" debate between two elected officials."
The Patrick campaign issued a statement from the Senator Thursday saying, " I'm happy that Mr. Ratliff has accepted my offer to debate the CSCOPE program, we look forward to a frank policy discussion about this issue on the 24th."
The campaign failed to respond to questions about Ratliff's request for a different format and venue.


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Alice Cooper described Billyboy Miskimmin as the best harp play he had heard since Paul Butterfield.
And the man from Belfast returns with his five-piece Mercy Lounge band, featuring high-standard musicians playing original rhythm and blues from the heart.
After almost 20 years touring the world with the likes of the Yardbirds and Nine Below Zero, Billyboy returns to Twickenham's Eel Pie Club in August.
He first wowed audiences with his techniques in the 1980s, playing with legends such as Jim Daly and Ronnnie Greer, before going on to play with the likes of BB King and the Doors.
Mercy Lounge; Eel Pie Club, the Patch, London Road, Twickenham; August 28, doors open 8.30pm; tickets £11 on the door; visit eelpieclub.com for tickets and more details.


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Opening Plenary: South East Europe Consultation on Reform of the child care system July 2007
Protecting children in the context of Poverty Reduction, Social Inclusion and Decentralization
Progress in childcare system reform in Bulgaria; remaining concerns and way forward
International partners in child welfare system reforms
European Union policy on social inclusion and its implications for children
World Bank involvement in social welfare system reform and lessons learned
UNICEF's contribution to the reform, and perspectives on child protection
Opening and Plenaries
Welcome session
Opening plenary session
Closing plenary session
Working Group presentations
SEE Consultation Working Groups:
WG1. Organisation of Statutory Services at the Local level
WG2. Family Substitute Services
WG3. Family and Child Support Services
WG4. Gatekeeping at National and Subnational Level - the role of the State
WG5. Targeting, forecasting and planning the establishment of a continuum of services
WG6. Costing and Financial Flows for Child Protection Services
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Thursday, January 11, 1900
A Nova Scotian V. C.
(Yarmouth Times)
The list of V. C.s, on which are now some 180 names, will doubtless be augmented during the present war. In running over the list of those who are entitled to wear the little bronze cross, one encounters the entry, "Hall, Seaman William, India, 1857;" and if it were known to the reader that Seaman Hall is one of the two colored men who have won the Victoria Cross, and lives near Avonport, Kings County, it would probably possess at least as much interest for him as such names as Redvers Buller, Evelyn Wood, Roberts of Kandahar, Sir George Stewart White, and others of prominence which appear in that distinguished category.
Mr. Hall was seen by the writer three years ago in his neat little home. He invited the Times reporter, that was to be, in, and told as much of the story of his exploit as his fading memory would allow. As an introduction he brought out a small box of medals, among which was the Crimea medal, bearing the clasp inscribed "Sebastapol." Beside this were many others, any one of which would cause a soldiers breast which bore them to swell with pride. But the trophy for which even the commander-in-chief would gladly barter his baton was the one which engrossed the writers attention, as he held it almost reverently. It is not much to look at. In fact, it is rather a clumsy affair; there is no beauty in it, or value either, intrinsically that is. But the little piece of metal told that its humble possessor had once gone unflinchingly into the jaws of death for his countrys sake.
Mr. Hall used to wear the cross upon his watch chain, and has lost the blue ribbon from which it was suspended. He was captain of the foretop on one of H. M. ships that went to India during the mutiny, and accompanied the famous naval brigade to Lucknow. It was during the siege of that place by Sir Colin Campbell that Mr. Hall performed the exploit of "conspicuous valor," indeed, that won him the Victoria Cross. Mr. Hall is well advanced in years and the circumstances attending that celebrated campaign are fading from his memory, but he recalls well how he and a lieutenant fought their gun after the rest of the crew had been killed beneath the high wall they at length succeeded in breaching. They ran the gun close to the walls. The slant of the loopholes were such that they were safe from the fire of the garrison when within a certain point, but at every shot the gun recoiled and ran back into the fire zone. As often as the gun ran back would Hall and his companion dart out after it amid deadly hail of bullets, roll it back again, load up and bang away at the evergrowing breach, until their heroic task was done. Their country owned their services, and the gallant young lieutenant and his devoted colored comrade received the highest distinction reserved for British heroes and the height of a British soldiers or sailors ambition. Few men can boast of such splendid service as can this fine old Nova Scotia negro, who is ranked among those whom the nation loves to honor.


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Empresas ICA
52-Week Range: $6.14-$13.73
Tuesday's Volume: 965,000
Three-Month Average Volume: 719,832 >>5 Rocket Stocks to Buy in August From a technical perspective, ICA ripped higher here right off its 50-day moving average of $7.48 with above-average volume. This stock has been uptrending strong for the last month and change, with shares moving higher from its low of $6.14 to its intraday high of $8.24. During that move, shares of ICA have been consistently making higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of ICA into breakout territory, since the stock took out some near-term overhead resistance levels at $7.93 to $8.08. Traders should now look for long-biased trades in ICA as long as it's trending above its 50-day at $7.48 and then once it sustains a move or close above Tuesday's high of $8.24 with volume that hits near or above 719,832 shares. If we get that move soon, then ICA will set up to re-test or possibly take out its next major overhead resistance levels at $9 to its 200-day moving average at $10.05. Any high-volume move above its 200-day will then put $11 to $11.77 into range for shares of ICA.


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The Boiler Room in Cape May's historic Congress Hall used to be just that - a place to store the hotel's water heater.
Now it gets steamy as a nightclub, with crowds filling the space to hear live music in an intimate atmosphere from mid-March through December.
"We make sure we represent the best of the entertainment in our area," general manager John Daily says.
Popular headliners often performing at the Boiler Room include American blues musician Frank Bey, Latin jazz artist Edgardo Cintron and a traditional rock and roll band The Billy D. Light Trio, Daily says.
Performing this weekend will be Third Degree Band with Margie Staples on Friday and BK&G on Saturday. BK&G stands for Bobby Hunter, Kit Worton and Greg Pordon, a trio of accomplished musicians who have individually backed some of the biggest acts in the entertainment world.
Daily says the musicians perform eye-level to the dance floor, making for up-close and personal entertainment. The Boiler Room also features a long bar and a smaller room off to the side with cocktail tables, both of which are ideal places to enjoy the music while holding a conversation.
Most people migrate to The Boiler Room after dinner at The Ebbitt Room, The Blue Pig Tavern or another nearby restaurant. The nightclub is open 8 p.m. to 1 a.m. on weekends and daily throughout the summer.
Featured Drinks:
The Boiler Room offers a full beer list featuring $6 crafts - Blue Pig Tavern Ale by Flying Fish Brewing Company, Harpoon IPA, Blue Moon Wheat and Samuel Adams Octoberfest - $5 imports and $4 domestics. They also offer wine by the glass and half-bottle and an extensive specialty cocktail menu.
The signature cocktail at The Boiler Room is the Congressional Cosmo, $10, made with Absolut Cintron, Cointreau, white cranberry juice and fresh lime.


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A woman was in critical condition late Tuesday after she was hit trying to cross East Laurel Drive in Salinas, police said.
The woman, in her 20s, stepped directly into the path of a vehicle traveling east near St. Edwards Drive about 7:15 p.m., police said. The impact forced her into the windshield, and she was thrown at least 25 feet.
The woman sustained major head trauma and was airlifted to a San Francisco Bay Area hospital, police said.
The driver was cooperative and did not appear to be under the influence, police said.


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Suggestions for Studying for Quiz 1
The first quiz will cover implicit differentiation and the material we learned last semester about finding derivatives. A good way to study for this quiz is to do some of the review problems on pages 298-301. You may use your calculator as long as it is a TI83/84 Plus or TI83/84 Plus Silver Edition, or has similar capabilities. You may not use a TI/89 on the quiz. If you have a calculator other than a TI83/84 Plus or TI83/84 Plus Silver Edition, please talk with me.
You will be tested on your ability to:
- State the formal definition of the derivative.
- Find a derivative using the difference quotient.
- Estimate the value of a derivative using a table.
- Use information about a function's first and second derivative to determine information about the graph of the function (and vice versa).
- Find derivatives using the the rules we learned last semester.
- Find the tangent line approximation (local linearization) of a function at a point and use it to approximate values of the function.
- Differentiate implicitly.
You should be able to:
- Use exponent rules to simplify expressions,
- Simplify complex fractions,
- Factor polynomials,
- Do other algebraic manipulations,
- Understand functions,
- Use your calculator to graph functions and find values of functions.
Students who have taken MCS118/119 in the past suggest that the best ways to study are:
- Study frequently, in small doses.
- Do the homework every night.
- Go to class, pay attention, and ask questions.
- Read the text sections to be covered before and after class.
- Use office hours and tutors.


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Family Law
Family Law Questions? Ask a Family Lawyer Online.
Although the abuse maybe happened, but I hope my daughter will not be hurt more as the agency join the case and start investigation. So I want to know:1. If abuse is sure, my daughter want to move to New York and live with us together, will her requirement be satisfied?2. I need a social worker for more information. Do you know how to reach a social worker?3. I want to be my daughter's guardian, what qualification requirements has the government on kid's guardian?
Although the abuse really happened, but I still hope my daughter hurts less.
1. If the abuse is true the government will take a shelter for her, I worry that my daughter is not willing to accept. If my daughter likes to go to New York and lives with us together, is it possible to achieve?
2. I want to be my daughter's guardian, what is the guardians qualification of government?
3. I need a social worker for more information, how can I reach?
Please give me links of regulations and laws about custody


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NewswireToday - /newswire/ -
Palo Alto, CA, United States, 2006/03/08 - Companies need to train lab personnel on the use of these new tests as well as educate physicians about the ability of these assays to improve the overall cost efficiency and patient outcomes..
Developers of assays for in-vitro diagnostics need to overcome the significant challenge of proving their technologies worth to rid potential end users of their skepticism about the reliability of new assays. Their apprehensions can be resolved only through effective demonstrations and education about the remarkable benefits of these assays.
Companies need to train lab personnel on the use of these new tests as well as educate physicians about the ability of these assays to improve the overall cost efficiency and patient outcomes. This can be achieved by demonstrating the use of these assays for accurate and early diagnosis of life-threatening diseases to physicians.
If you are interested in a virtual brochure, which provides manufacturers, end users, and other industry participants with an overview of the latest analysis of the In-Vitro Diagnostics Industry Impact, then send an e-mail to Melina Trevino - Corporate Communications at melina.trevino[.]frost.com with the following information: your full name, company name, title, telephone number, e-mail address, city, state, and country. We will send you the information via email upon receipt of the above information.
There has been wider acceptance of newly developed tumor and prostrate markers, breast cancer tests, and other assay technologies because of their high sensitivity as well as their specificity, fast turn-around times, easy-to-use interfaces, and low cross reactivity.
The tests need to be easily accessible to end-users across the world and not merely restricted to those in developed countries. It is vital to make them available in developing countries, where there is widespread prevalence of diseases requiring these assays.
Once companies identify the need and market for assays, it is imperative for them to find a suitable technology platform that can provide real-time, dependable, and accurate laboratory-grade results. Researchers also have to solve automation and integration issues during the development phase so that there is minimum human involvement, which in turn can lower costs.
Lack of automation in molecular diagnostics has led to high labor involvements right from the sample preparation stage. This necessitates access to highly automated nucleic acid isolation platforms.
After developing the assay technology, companies need to focus on its licensing and commercialization. Researching universities seek companies that can take a product from being a prototype to the commercialization phase through manufacturing, testing, clinical trials, regulatory review, and approval.
All assay platforms need a huge amount of validation over many years with a wide range of patient subjects as well as huge investments, says Frost & Sullivan Senior Research Analyst Sachin Thukral. Moreover, manufacturing companies need to produce systems that are smaller, faster, and easy to use.
The path to commercialization of a technology also involves meeting regulations, which differ from country to country. Companies may have to file for reimbursements separately in several countries for each assay added to an analyzer.
However, budgetary pressures have compelled governments to limit the reimbursements provided for assays. As a result, healthcare systems have to choose between better clinical tests at higher prices and those that offer lesser sensitivity and accuracy at lower prices.
Studies have demonstrated that reimbursement from Medicare is severely flawed and that often, new assays with greater benefits may be reimbursed with an equivalent or lesser amount than that provided for an already existing one, notes Thukral. Moreover, the Medicare fee schedule has not been revised due to inflation for 13 of the last 15 years and is not expected to be updated again till the end of 2008.
Nevertheless, the cost-containment measures of governments could compel healthcare organizations to use reliable, sensitive, and preventive assays to improve the quality of healthcare. This, in turn, can help them save considerable sums of money.
In-Vitro Diagnostics Industry Impact is part of the Technical Insights -- Healthcare vertical subscription service. The study offers an analysis of recent developments in the in-vitro diagnostics industry and identifies commercial applications. This research service enables companies to align their positioning strategies to benefit from emerging technologies. Executive summaries and analyst interviews are available to the press.
Technical Insights is an international technology analysis business that produces a variety of technical news alerts, newsletters, and research services.
Frost & Sullivan, a global growth consulting company, has been partnering with clients to support the development of innovative strategies for more than 40 years. The company's industry expertise integrates growth consulting, growth partnership services, and corporate management training to identify and develop opportunities. Frost & Sullivan serves an extensive clientele that includes Global 1000 companies, emerging companies, and the investment community by providing comprehensive industry coverage that reflects a unique global perspective and combines ongoing analysis of markets, technologies, econometrics, and demographics.
Written by / Agency / Source: Frost & Sullivan
Availability: All Regions (Including Int'l)
Traffic Booster: [/] Quick Newswire Today Visibility Checker
Distribution / Indexing: [+]


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Seeded by Brian Leonard (firstname.lastname@example.com).
This is the best copy of this show in circulation to my knowledge. I recieved it on disc
and EAC'd it myself. Thanks to Andy Singer for hookin' me up with this one that had been
on my wishlist for years!!
Tuning pauses have been shortened in some cases
Very very slight hiss
Encore (Sugar Mags) is missing, so if you have a good one from '77...!


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Report: Bowden expected to retire as FSU coach
TALLAHASSEE - Bobby Bowden's legendary coaching career at Florida State University is expected to end today, The Tallahassee Democrat learned. Bowden is expected to announce his resignation by way of a statement to be released today, sources told the Democrat. As part of his retirement, Bowden is expected to be offered a non-coaching position at FSU for an unspecified amount of time. In addition to any settlement compensation that may be negotiated, Bowden also is entitled to $1 million upon his retirement as part of a clause in his contract that was agreed upon at least 10 years ago. It is unclear if Bowden will coach the bowl game, but sources said if he does coach one last game, then the Gator Bowl might try to select FSU for its Jan. 1 game.A team meeting has been scheduled for this afternoon, another source told the Democrat. After reports of Bowden's resignation surfaced Monday, his wife, Ann, told The Associated Press and USA Today that her husband had not made a final decision. "I imagine, if there's any decision to be made, it would be Bobby's," she told USA Today. "Maybe we'll know something if they announce it. I haven't been informed of anything. Maybe we'll find out (today). ... I don't know a thing." Bowden's retirement means Jimbo Fisher will become the first head football coach FSU has hired in 34 seasons. "This is a major shift in the history of Florida State football," said prominent FSU booster Barry Smith, a former Seminole receiver and now a Tampa businessman. "You can't say enough about Coach Bowden and what he has meant for the program. He is more than a coach. He is an icon and has truly been a great father figure to so many of those kids. "Will he be missed? Of course he will. Jimbo has some unbelievably huge shoes to fill. But I think Jimbo is going to bring a new zest to the program." Fisher has spent the past three seasons on Bowden's staff as the offensive coordinator and quarterbacks coach. He was named the head-coach-in-waiting in December 2007 after his first season on staff. As Fisher flirted with overtures from other programs, including West Virginia, FSU president T.K. Wetherell orchestrated a deal that forced FSU to pay Fisher $5 million if he wasn't named head coach by January 2011. Setting a standard Bill Proctor, FSU's interim athletic director when the coach-in-waiting agreement with Fisher was announced nearly two years ago, said Monday that Bowden's expected announcement comes at a good time. "I think the arrangement is good," Proctor told The Tampa Tribune. "Whether the timing is right, that's based on Coach Bowden's decision. I wouldn't second-guess him at all. I have tremendous respect for him. He is a great gentleman and has just made a tremendous contribution to college football. He came to FSU when FSU was really talking about dropping football. What the man has done is nothing short of extraordinary." Bowden's expected announcement ends a 34-year run at FSU, where he built the football program into one of the country's best. His teams won 10 or more games for 14 consecutive seasons from 1987-2000 - a mark that is still considered the standard for excellence in major college football. 'The perfect solution' Longtime Bowden friend Hugh "Deacon" Jones, who grew up in Birmingham, Ala., and attended Woodlawn High with Bowden, talked to his friend Sunday night. Jones is not surprised Bowden plans to retire, considering the two options presented to him Monday morning during a meeting with Wetherell and FSU athletic director Randy Spetman - retire or take on a reduced coaching role. "I'm worried about him, but he sounded fine," Jones said. "Bobby's always upbeat. It was always that he was going to coach through 2010. The first I heard him move off that was after Saturday's game. I want him to get out with people still respecting him for the person he is and the coach he is. "If I'm reading between the lines, that's the perfect solution for Bobby and the school. They can all go away as friends and appreciate each other, and he can come up here and play golf." However, Jones understands the dilemma Bowden has talked about in making a decision about retiring. Bowden's coaching idol, former Alabama coach Bear Bryant, died shortly after retiring. "I quit my work when I was 53, and it took me six months to figure out what I was doing," Jones said. "It will take Bobby longer than that. He never wanted to do anything but coach." Bowden's teams won national championships in 1993 and 1999 and have played in a bowl game every year since 1982 - the longest active streak in the nation. Bowden's decision to retire stems from Monday's meeting with Wetherell and Spetman. The three men met for "about an hour," according to Bowden, who spoke at his weekly FSU booster luncheon afterward. "(Today) we're going to meet again and have an announcement whether or not I'll be here at Florida State (and) continue another year," Bowden said.
Tribune reporter Scott Carter contributed to this report.
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Florida university chancellor forced out for pretending to be on campus during Hurricane Irma evacuation


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CARSON, Calif. – When Chivas USA took the field for arguably their most important game of the season on Saturday, they did so without their defensive leader. Veteran Heath Pearce was relegated to watching from the stands, nursing a hamstring strain that could keep him out for another month.
The absence of the US national-teamer, who previously had started every game this season, forced head coach Robin Fraser to use new personnel against D.C. United.
It didn't work. Without their ironman on the field, the Rojiblancos defense suffered, falling 3-0 to DC due largely to several miscues on the defensive side of the ball.
"Looks pretty significant now doesn't it?" said Fraser when questioned about Pearce's absence. "You'd like to think when you build a team that you get a system and you can plug players in if someone has to be out. ... Obviously today, the back group didn't play well enough, plain and simple."
The inability of the back four to get on the same page was the story of the game. Brazilian David Júnior Lopes was making his second start in MLS while Ben Zemanski played at right back for the first time in his two-year career, joining regulars Michael Umaña and Ante Jazic.
The match was a trying one for Zemanski, whose failed clearance in the 16th minute of play fell to Chris Pontius, setting up Charlie Davies' second of three goals on the night. Fraser had felt confident in giving the position to Zemanski while more experienced options – including rookie Zarek Valentin and second-year man Mike Lahoud – recovered from nagging injuries.
"We've had injury issues at right back recently and players are coming back into full fitness," explained Fraser. "At the end of the day, Zemanski is a guy that battles no matter where he plays, and the thinking was, if we're perhaps uncertain with [right back], then let's go with the guy that has filled in admirably in a number of different positions for us through heart and desire."
Looking ahead toward Chicago on Saturday, the Goats' once reliable backline will again be stretched to the brink. However with Lahoud and Valentin returning to full fitness, it is likely that one of the two will see time at right back.
There are questions at center back, however. Pearce is still out and Júnior Lopes is unavailable after picking up a red card against DC. Without them, there will be an opportunity for players further down the depth chart to stake a claim for the stretch run.
"We've got Andy Boyens, who has been training hard, and it's an opportunity," said captain Simon Elliott. "Heath's on the mend, he'll be back soon, but you have to look at it as an opportunity for someone to be raising their hand and saying, 'I deserve to play every week.' It's 'what are you preparing to do' time."
Adam Serrano covers Chivas USA for MLSsoccer.com. He can be reached at email@example.com and on Twitter: @adamserrano