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Members of the Armed Forces, originally from the mid-Michigan area, have made accomplishments in their respective branches.
• Pfc. Trenton M. Gonyaw graduated from basic combat training at Fort Jackson, Columbia, S.C. He is the son of Laurel Gonyaw of Bay City.
• Pvt. Matthew M. Young graduated from basic combat training at Fort Leonard Wood, Waynesville, Mo. He is the son of Michelle Albertson of Saginaw, and is a graduate of Bridgeport High School.
• The following privates graduated from basic combat training at Fort Jackson, Columbia, S.C.: Devon E. Bates, son of Lorelei Hill of Bay City; JaQuese J. Hilburn, daughter of Latorian Woodard and Roberto Hilburn, both of Saginaw; and Jonathan R. Knapp, son of Richard and Mary Ann Knapp of Midland.
• Pvts. Theron Bogart and Raini J. Lucas graduated from basic combat training at Fort Jackson, Columbia, S.C.
Bogart is the son of Larry and Deb Bogart of Cass City.
Lucas is the son of Jody and Robert Lucas of Bay City.
• Pvt. Tyler A. Church graduated from basic combat training at Fort Jackson, Columbia, S.C. He is the son of Christopher Church of Midland.
• Airman Amanda B. Evenson and Petty Officer 2nd Class Justin D. Wilson, along with other sailors aboard the aircraft carrier USS John C. Stennis, recently arrived in Singapore for a schedule port visit. This is the first port visit since entering the U.S. 7th Fleet area of responsibility after five months of operating in and around the Arabian Gulf.
Evenson is the daughter of Lori A. and Denny P. Curtis of Standish.
Wilson is the son of Amy L. Wilso and Mark E. Wilson, both of Saginaw.
• Constructionman Recruit Ashley M. Smith, daughter of Cheryl L. and Richard E. Richter of Saginaw, along with sailors attached to the Naval Mobile Construction Battalion 11, recently received the Rear Admiral Eugene J. Peltier Award for fiscal year 2012.
Units selected for this prestigious award are recognized leaders in the Naval construction force in safety, overall performance, readiness, construction accomplishment, equipment management, logistics programs, retention and training.
The battalion, homeported in Gulfport, Miss., completed an eight-month deployment in Afghanistan during 2012 which set the stage for the surge drawdown of U.S. and coalition forces, and eventual transfer of the mission to the Afghan forces.
This Seabee battalion specializes in contingency construction, disaster response and humanitarian assistance.
• The following airmen graduated from basic military training at Lackland Air Force Base, San Antonio: Michael E. Hawkins, son of Paul and Kathy Hawkins of Shepherd; Jacob G. Leuenberger, whose mother and stepfather are Wendy North and Tim Garinger, both of Saginaw; and Kirt F. Shields Jr., son of Kirt Shields and Patricia Reyes, both of Saginaw, and graduate of Merrill High School.


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UT-A3 has recently been identified as a splicing variant transcript of the UT-A gene present in the kidney. To study the cellular and subcellular localization of UT-A3, we raised a new polyclonal antibody to its COOH-terminal end. Immunoblots identified bands at 44 and 67 kDa predominately in the inner medulla and showed that the antibody does not recognize UT-A1. Deglycosylation with PNGase decreased the molecular mass of both forms to 40 kDa. UT-A3 is most abundant in the inner third of the inner medulla and is present in membrane fractions. Cell fractionation studies showed that UT-A3 is only detectable in inner medullary collecting duct (IMCD) cells. These observations were confirmed with immunolocalization studies demonstrating an exclusive labeling of IMCD cells. Double-labeling studies with anti-Na-K-ATPase demonstrated UT-A3 in intracellular membranes and in the apical region but were incompatible with a basolateral site for UT-A3. Although the function of this isoform in the inner medulla is unknown, the large abundance suggests that it may be important in the renal handling of urea.
- urinary concentrating mechanism
- inner medullary collecting duct
the physiological basis of renal urea transport has been greatly clarified by the identification of distinct epithelial urea transporters via molecular cloning (21, 22, 29). Initially, two transporters were identified that were transcribed from the same gene from two distinct promoters. This gene has been referred to as "UT-A" to distinguish it from the gene coding for a urea transporter expressed in erythrocytes and endothelial cells, termed "UT-B" (18). The larger of the UT-A isoforms, termed "UT-A1," (originally called UT1) has an open reading frame of 929 amino acids (21) and is expressed solely in the inner medullary collecting duct (IMCD) (19). A second isoform, termed "UT-A2" [originally called "UT2" (22, 29)] corresponds to the COOH-terminal 397 amino acids of UT-A1. RT-PCR studies in microdissected renal tubules (19) found UT-A2 mRNA in the descending thin limbs of short loops of Henle in outer medulla and in descending limbs of long loops of Henle in inner medulla. UT-A2 expression appears to be absent in descending limbs of long loops in outer medulla. Northern blotting studies have revealed that the abundance of the UT-A2 transcript is increased in rats in response to water restriction (22) and by arginine vasopressin (AVP) infusion (15, 20). UT-A1 mRNA abundance, however, does not appear to be consistently increased by AVP infusion (15) and may even be decreased slightly (20).
Immunolocalization studies of UT-A isoforms showed that peptide-directed antibodies raised to the COOH terminal of UT-A1 (whose COOH-terminal sequence is identical to that of UT-A2) labeled both the IMCD and the thin descending limbs of Henle's loop (13). Immunoblots run with membrane fractions from the inner medulla revealed bands of 97 and 117 kDa (13, 25). The two sizes are the result of different amounts of glycosylation of the same core protein (1). Chronic elevation of AVP in rats does not appear to change the abundance of the 97-kDa form and decreased the abundance of the 117-kDa form (25). A recent study used surface biotinylation to carefully examine the possibility that UT-A1 might traffic to the apical surface of IMCD cells in response to AVP (6). Although trafficking of aquaporin-2 (AQP2) could be clearly shown, the distribution of UT-A1 was unaltered under conditions known to strongly stimulate IMCD urea permeability. On the basis of these data, the prevailing view in the field is that UT-A1 responds to AVP by mechanisms different from AQP2. Recently, the UT-A gene has been shown to produce at least two other transcripts with the cloning of cDNAs for UT-A3 and UT-A4 (8). The renal tubular localization and functional roles of these transcripts remain undefined. The present work describes a new antibody raised to the COOH terminal of UT-A3 that does not appear to recognize UT-A1 or other known urea transporters. This work localizes UT-A3 to the terminal portion of the IMCD.
Experimental animals.
All experiments were conducted in accord with animal protocols for rats approved by the Animal Care and Use Committee of the National Heart, Lung, and Blood Institute. Pathogen-free Sprague-Dawley (Taconic Farms, Germantown, NY; National Cancer Institute, Frederick Cancer Research Facility, Frederick, MD) male rats, weighing 192–225 g, were used in these studies. Body weights of all rats were carefully matched in each protocol, and animals were fed an ad libitum intake of a standard rat chow containing 18% protein and 130 meq Na+/kg (NIH-31 autoclavable rodent diet, Ziegler Brothers, Gardner, PA). The rats were kept in filter-top microisolator cage with autoclaved feed and bedding, to maintain a pathogen-free state.
To obtain the anti-UT-A3, the polyclonal antibody used in these studies, a synthetic peptide was designed for specificity, antigenicity and absence of posttranslational modifications using computer analysis. They were produced by standard solid-phase, peptide-synthesis techniques, purified by high-performance liquid chromatography, and conjugated to maleimide-activated keyhole limpet hemocyanin via covalent linkage to the NH2-terminal cysteine. For each antibody, two rabbits were immunized by using a combination of Freund's complete and incomplete adjuvants. The antisera obtained were affinity purified by using a column on which 2 mg of the immunizing peptide were immobilized via covalent linkage to agarose beads (SulfoLink Kit; Pierce, Rockford, IL). The following published and characterized antibodies were used for these studies: rabbit L194 and L403 [UT-A1, UT-A2, and UT-A4 (characterized in Refs. 13and 25; COOH-terminal 19 amino acids 911–929; sequence: H2N-QEKNRRASMITKYQAYDVS-COOH)]; rabbit L448 [UT-A1 (characterized in Ref. 25; middle loop, amino acids 500–522; sequence: NH2-KVFGKSEHQERQTKEPLPYLYRK-COOH)]; rabbit Q2 [UT-A3 (amino acids 447–460; sequence: NH2-TAKRSDEQKPPNGD-COOH)]; and rabbit L446 [UT-A1, UT-A3, UT-A4 (characterized in Refs. 1 and27; amino acids 56–78; sequence: NH2-EEKDLRSSDEDSHIVKIEKPNER-COOH)].
Other antibodies used were to aquaporin-1 (AQP1; L266, characterized in Ref. 24), AQP2 (L751, sequence: NH2-VELHSPQSLPRGSKA-COOH) and to Na-K-ATPase (Upstate Biotechnology, Lake Placid, NY).
Tissue preparation and immunoblotting.
The rats were euthanized by rapid decapitation. Kidney homogenates were prepared according to Terris et al. (25). Briefly, the kidneys were removed and one kidney was dissected into inner medulla, outer medulla, and cortex. The tissues were homogenized with an Omni 1000 fitted with a microsawtooth generator in ice-cold isolation solution (adjusted to pH 7.6 with NaOH) containing 250 mM sucrose/10 mM triethanolamine, 1 μg/ml leupeptin, and 0.1 mg/ml phenylmethylsulfonylfluoride. Some samples were centrifuged at 200,000g for 1 h (Beckman L8-M ultracentrifuge with a type-80TI rotor) to produce a plasma membrane- and intracellular vesicle-free supernatant. The total protein concentration of all samples was determined with a Pierce BCA Protein Assay reagent kit (Pierce) and adjusted to ∼1 μg/μl with isolation solution. Laemmli buffer (5×; 7.5% SDS, 30% glycerol, 1 M Tris, pH 6.8, bromophenol blue) with 30 mg/ml dithiothreitol (DTT) was added to the samples in a ratio of 1:4 and heated to 60°C for 15 min.
Electrophoresis was performed on Bio-Rad polyacrylamide minigels, and the proteins were transferred electrophoretically to nitrocellulose membranes. After blocking with 5% nonfat dry milk for 30 min, the nitrocellulose membranes were probed with affinity-purified antibody, described above, for 24 h at 4°C, washed, and exposed to secondary antibody (donkey anti-rabbit IgG conjugated with horseradish peroxidase, Pierce no. 31458). Sites of antibody-antigen reaction were visualized by using luminol-based enhanced chemiluminescence (LumiGLO, Kirkegaard and Perry Laboratories, Gaithersburg, MD, or SuperSignal, Pierce). The blots were quantitated by densitometry (model PDSI-P90, Molecular Dynamics, Sunnyvale, CA).
Fixation of tissue and immunocytochemistry.
Kidneys of ketamine-xylazine-anesthetized rats were fixed with 2% paraformaldehyde in PBS by retrograde perfusion through the abdominal aorta, and antibodies were immunolocalized on frozen sections as previously described (27). Sections were incubated overnight at 4°C with primary antibodies diluted to 10 μg/ml. Secondary antibodies were species-specific donkey anti-rabbit and donkey anti-mouse antibodies (Jackson Immunoresearch Labs, West Grove, PA) coupled to Alexa 488 and Alexa 568, respectively (Molecular Probes, Eugene, OR).
Preparation of IMCD suspensions.
Suspensions were prepared as described by Chou et al. (2). The rats were injected with 0.5 ml furosemide (10 mg/ml), and 20–30 min later were rapidly decapitated. Both kidneys were perfused with 15 ml of ice-cold dissection fluid to wash out blood and perfused with 20 ml of prewarmed digestion solution containing 2 mg/ml collagenase B (Boehringer Mannheim, Indianapolis IN), 540 U/ml hyaluronidase (Worthington Biochemical, Freehold, NJ), and 0.5 mg/ml bovine serum albumin dissolved in the basic bicarbonate-buffered tubule suspension solution containing (in mM) 118 NaCl, 25 NaHCO3, 4 Na2HPO4, 2 CaCl2, 1.2 MgSO4, 5 glucose, and 5 sodium acetate (300 mosmol).
After removal of both kidneys, the inner medullas were dissected and finely minced with a razor blade into 1-mm cubes. The minced tissue was transferred into 12 × 75-mm glass tubes, suspended in the same digestion solution, and incubated at 37°C with 95% air-5% CO2 superfusion. After a 30-min initial incubation period, DNase I (Boehringer Mannheim) was added to a final concentration of 0.001%, and the incubation continued for another 20 min. The suspensions were aspirated with a large-bore Pasteur pipette every 15 min to break up large tissue fragments. After the incubation, the suspensions were transiently (10 s) centrifuged at 50 g, and the pellet was resuspended in tubule suspension fluid containing 0.001% DNase I. The supernatants were discarded. This procedure was repeated two more times, and the supernatants were combined. The resulting inner medullary pellet suspensions consisted almost entirely of collecting duct fragments with only very few thin limb fragments, as confirmed by viewing the suspensions under a dissection microscope. The final pellet was resuspended with 1.5–2 ml of tubule suspension fluid to yield a protein concentration of ∼10 μg/50 μl of suspension.
Figure 1 shows a schematic representation of UT-A1 and UT-A3 proteins illustrating epitope locations recognized by the antibodies employed in this study. H1-H4 represent hydrophobic regions likely to contain membrane-spanning domains. The L403/L194 antibodies, previously characterized (13,25), label an epitope at the COOH terminus of UT-A1 not found in UT-A3. For the studies reported here we also utilized antibodies that recognize epitopes in the intracellular loop of UT-A1 (L448) and the NH2 terminus of UT-A1 and UT-A3 (27). The UT-A3 isoform is homologous to the first 460 amino acids of the NH2-terminal end of UT-A1, except that the COOH-terminal amino acid of UT-A3 is aspartic acid whereas the corresponding amino acid in UT-A1 is glycine. The anti-UT-A3 antibody (designated "Q2") was raised to amino acids 447–460 of the COOH terminus of UT-A3.
Characterization of UT-A3-specific antibody.
Figure 2 is a Western blot probed with the Q2 antibody and shows regional localization of bands at 44 and 67 kDa, consistent with the predicted molecular weight of UT-A3 plus glycosylation. For this blot, tissue from the inner medulla, outer medulla, and cortex was homogenized and centrifuged at 17,000g to obtain membrane pellets. The inner medulla was cut into thirds, IM3 representing the inner third (papillary tip), IM2 the middle third, and IM1 the initial third (base). The greatest abundance of both bands was in the inner third of the inner medulla. A light band at 67 kDa was also found in the outer medulla, consistent with the detection of mRNA for UT-A3 there (8). Neither of these bands was detected in the cortex. Interestingly, despite the homology of all but one amino acid with UT-A1, no significant amount of UT-A1 protein (97 and 117 kDa) was detected in any region by this antibody. Other studies (not shown) suggest that the lighter, higher molecular weight proteins labeled in the IM3 and IM2 regions are dimers of UT-A3 proteins.
To further characterize the 44- and 67-kDa proteins, fresh aliquots of the samples used for Fig. 2 were probed with the L446 antibody, specific for a site near the NH2 terminus of UT-A1, UT-A3, and UT-A4. This blot was compared with one probed with antibody L448, specific for an epitope found only in UT-A1. Figure3 shows the results. As expected, L448 labeled proteins in the inner medulla in a pattern and with molecular masses (97 and 117 kDa) consistent with UT-A1. In addition to these UT-A1 proteins, L446 also identified bands at 44 and 67 kDa, the same size as those recognized by the Q2 antibody. Detection of 44- and 67-kDa bands by both Q2 and L446 supports the view that the two antibodies are detecting the same proteins, i.e., UT-A3. Note also that antibody L446 recognizes bands in the cortex that may represent other short UT isoforms.
To evaluate the specificity of the Q2 antibody for UT-A3 protein, preadsorption controls were carried out. Blots were prepared utilizing the 17,000-g fraction from the inner third of the inner medulla (Fig. 4,A–C). The blot in A was carried out with Q2 antibody previously incubated overnight with the immunizing peptide, whereas the blot in B was done with the Q2 antibody incubated alone. All bands were ablated after preincubation with the specific peptide. Note that there are no UT-A1 protein bands at 97 and 117 kDa in B. The blot in B was then stripped of IgG and reprobed with L403 to verify the position of the UT-A1 bands in the blot (C).
Figure 5 shows the immunoblots using 17,000- and 200,000-g pellets and the 200,000-gsupernatant from the three regions of the inner medulla. As previously reported for UT-A1, the greatest abundance of UT-A3 was also in the inner third of the inner medulla, decreasing in abundance in the middle third and base in both the membrane-enriched and intracellular vesicle-enriched fractions. In these heavily loaded gels, high-molecular-mass bands are also detected that appear to be multimers of the UT-A3 protein. There was no detectable protein in the 200,000-g supernatant.
Glycosylation of UT-A3.
To test whether the 44- and 67-kDa proteins are glycosylated, 17,000- and 200,000-g aliquots from the inner third (IM3) of the inner medulla were incubated at 37°C for 1 h with vehicle (−) or PNGase (+) (Fig. 6). Another aliquot (c) was incubated at 4°C to control for possible nonspecific effects of the 37°C incubation. Figure 6 shows that, after incubation with the enzyme, there is a single band at ∼40 kDa, suggesting that the two bands represent different glycosylation states of a single protein. It is significant to note that the 97- and 117-kDa protein bands of UT-A1 are again absent in these blots probed with Q2. The absence of these bands further supports the view that the Q2 antibody does not significantly recognize UT-A1 protein, although, with the exception of the COOH amino acid, it is specific for an epitope also found in the middle loop of UT-A1. The lack of recognition of UT-A1 could be explained if the epitope were inaccessible to the antibody when the loop is intact, as it would be in UT-A1. With UT-A3, the COOH-terminal end is freely available to the antibody.
Localization of UT-A3 to IMCD.
To characterize further the localization of UT-A3 protein, IMCD enriched and non-IMCD enriched suspensions, consisting primarily of thin limb segments, were probed with the Q2 antibody. As can be seen in Fig. 7, UT-A3 protein was not detected in the non-IMCD enriched sample, whereas it was found in the whole inner medulla and IMCD enriched fractions, strongly suggesting localization to the collecting duct. This UT-A3 blot was then sequentially stripped of IgG and reprobed for UT-A1, AQP2, and AQP1 proteins. UT-A1 and AQP2, marker proteins for the IMCD (4, 13), showed a distribution similar to that of UT-A3. To verify the presence of protein in the non-IMCD lane, the blot was probed for AQP1 (thin descending limb marker). As expected, the greatest abundance of AQP1 was found in the non-IMCD enriched fraction.
Immunolocalization of UT-A3.
Antibody Q2 was used to localize UT-A3 by immunocytochemistry. Figure8 shows a low-magnification localization of Q2 labeling in inner medulla (A) with respect to Na-K-ATPase (B). No specific labeling was detectable in the cortex or outer medulla with antibody Q2. Very weak labeling was present in the base of the inner medulla in the IM1 zone, with progressively increased labeling of IMCDs in the intermediate IM2 zone and very strong labeling in the IM3 zone at the tip of the papilla. This labeling pattern corresponds closely to the pattern of labeling seen in immunoblots of these zones (Fig. 2).
The abundance of UT-A3 protein in the IMCD suggests it may be important in renal urea handling. One possible function for another urea transporter in the IMCD would be to function as the basolateral urea transporter. We tested this hypothesis by immunolocalizing Q2 labeling with respect to Na-K-ATPase as shown in Fig.9. Q2 labeling (A) is distributed throughout IMCD cells (presumably in small vesicles) but fails to label the lateral cell membrane (arrows), which are strongly labeled by anti-Na-K-ATPase (B). In Fig. 9 C, labeling by Q2 antibody (shown in red) is directly compared with respect to anti-Na-K-ATPase (shown in green) and shows that UT-A3 labeling overlaps with anti-Na-K-ATPase (shown in yellow) very minimally at the basolateral surface. This localization is consistent with an insignificant expression of UT-A3 in the basolateral plasma membrane.
Urea transport by the kidney is critically important to the urinary concentrating process and regulation of renal water excretion (10, 11). Our understanding of renal urea transport in has been greatly advanced by the identification of distinct epithelial urea transporters via molecular cloning (21, 22, 29). Thus far three urea isoforms have been characterized and localized in the kidney. Of the two UT-A isoforms, UT-A1, also called UT1 (21), produces bands at 117 and 97 kDa (13,25) and is expressed only in the IMCD (19). A second UT-A isoform, termed "UT-A2" (originally called "UT2") (22, 29) corresponds to the COOH-terminal 397 amino acids of UT-A1. UT-A2 is a 55-kDa protein expressed in the descending thin limbs of short loops of Henle in the outer medulla and in descending limbs of long loops of Henle in the inner medulla (19,27). A third renal urea transporter originally called HUT11 (14) and now known as UT-B1 (18) is produced by another gene and localizes to the vasa recta of the renal medulla (26, 28). On the basis of the finding that previous urea transporter isoforms have each localized to distinct renal sites, it was of interest to determine whether the newly identified UT-A3 isoform (8) would be expressed in a distinct renal segment.
Development of UT-A3-specific antibodies.
Previous immunolocalizations of UT-A isoforms (13, 27) used antibodies raised to the COOH-terminal 19 amino acids of UT-A1 whose COOH terminus is identical to that of UT-A2 and UT-A4. These antibodies labeled not only the IMCDs but also the thin descending limbs of Henle's loop, consistent with the expectation that UT-A1 and UT-A2 would both be recognized. Because the different urea transporter isoforms that have been described are alternative splice forms of UT-A1, we believed that it would not be possible to produce antibodies to the short isoforms that do not recognize UT-A1. This represents a major problem for strategies to understand the function of each isoform. Here we characterized an antibody to the COOH terminal of UT-A3 (called "Q2") that would be expected to also recognize UT-A1 because it differs from the sequence for that isoform by only one amino acid. However, immunoblots with this antibody show no labeling of the 97/117-kDa bands known to be UT-A1. There are two strong bands at 44 and 67 kDa in the size range expected for UT-A3 that are ablated by the immunizing peptide. Furthermore, deglycosylation of samples with PNGase showed that both forms are glycosylated forms of the same core protein. The absence of the UT-A1 bands from blots with Q2 supports the view that this antibody does not significantly recognize UT-A1 protein, at least to the extent detectable by immunoblotting. The lack of recognition of UT-A1 could be explained if the epitope were inaccessible to the antibody when the loop is intact, as it would be in UT-A1 or because the epitope depends on the one amino acid that differs between UT-A1 and UT-A3. With UT-A3, the COOH-terminal end could be freely available to the antibody.
Site of UT-A3 expression.
Our immunolocalization studies show that UT-A3 localizes to the terminal portion of the IMCD in a pattern very similar to UT-A1. This was established by two independent assessments. Purified suspensions of IMCDs were prepared using established methods (2), and these blots showed that labeling by the Q2 antibody to UT-A3 was strongly enriched in the IMCD over non-IMCD fractions. The IMCD fraction was rich in AQP2 and had less AQP1 than the non-IMCD fraction, as expected. These findings suggested that UT-A3 is expressed in IMCDs. This was also demonstrated by immunofluorescent localizations showing that Q2 labels IMCD cells with progressively greater intensity toward the tip of the inner medulla.
Possible functional role of UT-A3.
The large abundance of the protein in samples from the tip of the inner medulla suggests UT-A3 may be important in renal urea handling. Physiological measurements have developed evidence for the presence of a phloretin-sensitive pathway for urea at the basolateral as well as the apical surface of the IMCD (3, 23). Because one possible function for UT-A3 in the IMCD would be to function as the basolateral urea transporter, we tested that hypothesis by immunolocalizing Q2 with respect to Na-K-ATPase. The absence of overlap at the basolateral surface is inconsistent with a basolateral function for UT-A3, making it very unlikely that UT-A3 represents the basolateral urea transporter. This function might be accomplished by AQP3, which has been shown to be permeable to urea as well as water (7). Alternatively, basolateral urea flux might be carried out by UT-A4 or another uncharacterized UT (5).
UT-A3 may have a role in mediating the well-established action of AVP on IMCD urea permeability (11, 17). On the basis of the localization of UT-A1 in IMCD cells, it has been presumed that UT-A1 is involved in this action of AVP (21). If so, the regulatory mechanism involved is very different from the action of AVP action on water permeability because neither translocation of UT-A1 (6) nor changes in its abundance appear to occur in response to AVP stimulation (25). UT-A1 expression is, however, regulated by other factors (9, 12, 16, 25). Our finding that the IMCD expresses more than one urea transporter isoform raises the possibility that UT-A3 may mediate the effect of AVP on IMCD urea permeability. Additional work will be required to determine whether UT-A3 functions in this or some other role in the IMCD.
We thank Jie Liu for expert technical help with immunolocalizations.
This work was supported by National Diabetes and Digestive and Kidney Diseases Grant DK-32839 (to J. B. Wade) and by the intramural budget of the National, Heart, Lung, and Blood Institute (project no. Z01-HL-01282-KE; to M.A. Knepper). The Confocal Microscope Facility used for the immunolocalizations was funded by National Science Foundation Grant BIR9318061.
Address for reprint requests and other correspondence: J. B. Wade, Dept. of Physiology, 655 W. Baltimore St., Univ. of Maryland, Baltimore, MD 21201 (E-mail: jwade{at}umaryland.edu).
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2001 the American Physiological Society

subset: commoncrawl


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Dallas' Most Interesting Restaurants No. 22: Small Brewpub
The dishes at Small turn brewpub cliches on their heads.
Kathy Tran
Leading up to our annual Best of Dallas® issue, we're counting down the 50 most interesting restaurants in Dallas. These spots bring something unique or compelling to the city's dining scene, feeding both your appetite and soul.
Normally, brewpubs produce menus that represent everything this list is not about. Picture pretzels with some sort of dip made with beer and cheese, a dry burger and a nacho platter. Brewpubs are supposed to focus on brewing beer; the food is an afterthought. Unless, of course, we're talking about Small Brewpub in Oak Cliff.
Sure, the spot opened late last year and has proceeded to turn out some exemplary beer. Don't pay the place a visit and pass up the peppercorn pilsner, and then do your best to work your way through their well-curated cocktails list.
But it's the food that really makes Small stand out — and not just for a brewpub. The pastas are rolled out by hand, the sauces and condiments are made on-site (all the way down to the vinegars) and chef Misti Norris oversees a house charcuterie program packed with delicious swine, including face bacon.
Then there are the pickled eggs, jerky and other snacks. It's a wonder that this place can even be referred to as a brewpub at all. Sure, there are fermentation tanks filled with beer in the corner, but Norris produces cooking that's on par with fine-dining. It's impossible to get bored while eating here.
Your opinion matters! Be sure to weigh in on our Best Of Dallas Readers' Choice poll. Voting ends September 6.
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333 W. Jefferson Blvd.
Dallas, TX 75208
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Urbandale Restaurant Guide & Dining Reviews
Featured Review
Dim Sum is available on Sundays. I think the hours for dim sum are approximately 11:00 AM until 2:30 or 3:00 PM. It's great to have a dim sum availability in central Iowa again.
Check out the Best Urbandale Restaurant Deals.
Recent Urbandale Restaurant Guide Reviews
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"The breading on the dim sum's dish was heavy and the meat was not fresh. We also order from the Menu and the breading was more than it should be as compare to other resturant in the same industry. If you have dim ... "
Nana's Pizza Pasta Grill
"My very favorite restaurant in all of Des Moines. The food is always excellent and hot when served. Atmosphere is quiet and friendly."
Nana's Pizza Pasta Grill
"Husband and I love it!!! Best place to eat! Professional staff/very clean/wonderful ambience/EXCELLENT food!!!"
Nana's Pizza Pasta Grill
"Excellent!!!! Best food for the buck! Employees helpful and professional. Restaurant was clean and attractive. We aren't just telling our friends, we are bringing our friends!!!!"
J Benjamin's
"Excellent food and service. Highly recommended!"


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HONOLULU • The security footage looks unassuming at first: a Hawaiian Airlines jet parked at a gate at the Maui airport under overcast skies, and workers going through their regular routine. Then, the 15-year-old's legs dangle briefly from the plane's belly and he drops to the concrete.
Hawaii transportation officials released video Tuesday of a California teen hopping from a jet's wheel well April 20 after stowing away for a 5½-hour flight. The video largely confirms previous accounts given by FBI and airport officials of Yahya Abdi's seemingly unbelievable story that he ran away from home, hopped a fence at Mineta San Jose International Airport and climbed into the wheel well of the closest plane.
Abdi survived the flight at 35,000 feet despite low oxygen and freezing temperatures.


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This was created digitally using free-hand drawing tools initially in MS PPT, then layered with textures and the same image with less opacity in PSEv9. I then enhanced it with several color and textured filters using Paintshop Pro X4, Color Efex v3 and Topaz Adjust v5 Simplify v3. I plan to have it produced on large canvas as a house warming gift for my oldest son and his wife, who are in the process of building a new home. (If they don't like it…I may just keep this one for myself =D)
Featured in the INTERNATIONAL SHOWCASE Group on October 27, 2013
Featured in the INSPIRED ART Group on April 23, 2012!
Featured in the PAINTER'S UNIVERSE Group on April 21, 2012!
Featured in the COLOR ME A RAINBOW Group on April 17, 2012!
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Would the ICC help in Syria?
- By David BoscoDavid Bosco is an associate professor at Indiana University's School of Global and International Studies. He is the author of books on the U.N. Security Council and the International Criminal Court, and is at work on a new book about governance of the oceans.
After several months of relative inattention to the issue, there's been a renewed push in the past week to get the International Criminal Court (ICC) involved in Syria. The centerpiece of that effort is a letter drafted by the Swiss government and endorsed by dozens of other countries. Recognizing that the court currently lacks jurisdiction, it calls on the UN Security Council to refer the Syria violence to the Hague-based court, which can prosecute genocide, crimes against humanity, and war crimes. Leading human rights organizations have thrown their weight behind the initiative.
For all the support the Swiss missive has generated, the chances of an ICC referral still look slim. Russia, China and the United States, whose acquiescence is essential, have not backed the call. There's no evidence I'm aware of that they're shifting position on the issue. Their reasons for opposing an ICC role are likely quite different. Russia has consistently backed the Assad regime and knows that an ICC investigation would likely focus on regime higher-ups. China is generally skeptical of the court and intervention in what it sees as internal affairs; Beijing only reluctantly agreed to referrals for Sudan and Libya.
The U.S. decision not to openly support a referral is the most interesting. The Obama administration has taken several steps to improve cooperation with the court and voted for the Libya referral (the Bush administration had abstained on the 2005 Sudan referral). However it appears that the speed with which the ICC prosecutor moved in the Libya case unnerved some administration officials, who worried that the indictments against Moammar Gaddafi, his son, and the regime's intelligence chief might foreclose a negotiated solution. That experience is likely influencing the administration view on Syria.
With three of the Security Council's permanent members unpersuaded, the question of an ICC role in Syria is an academic one. But it's an important academic one, and the Swiss effort has shed some light on what advocates of international prosecutions hope they would achieve. Below are several of the anticipated benefits that have been discussed:
1. An ICC role would deter Syrian government and rebel leaders from committing further crimes. The Swiss letter anticipates that a referral would have "an important dissuasive effect." This expected benefit–often discussed in terms of the "signal" that a referral would send to the warring parties–has been implicit in most of the commentary.
2. An ICC role would encourage greater discipline in the ranks of fighters on both sides. This anticipated effect is somewhat distinct from the deterrent impact on leadership figures. It suggests that local commanders might take greater care in supervising operations to ensure that they don't become the focus of investigations. A commentary by the foreign ministers of Austria, Slovenia, Ireland and Denmark (the "ASID commentary") predicted that "a referral to the ICC would make clear to every fighter on all sides of the conflict that the gravest crimes will eventually be punished."
3. The prospect of ICC prosecutions would help prevent usage of chemical or biological weapons. The legal scholar Jennifer Trahan has argued that the use of these weapons would "raise criminality to a new level that would invite high level prosecutions."
4. An ICC role would encourage defections from the Assad regime. The ASID commentary argued that an international investigation would "give the members of the al-Assad regime a further reason to question their allegiance."
5. ICC prosecutions would marginalize abusers and thereby make a negotiated solution more likely. The ASID commentary included this analysis: "As we saw in other crises, parallel political and judicial processes are mutually supporting. There is no decision to be taken here between either peace or justice – a sustainable, long-term solution requires both." For a further elaboration of this argument, see last week's Human Rights Watch press release.
These claims all come embedded in a broader, principle-based argument: that doing justice is the right thing. But to the extent advocates lean on arguments about the expected consequences of prosecutions, they invite scrutiny based on our growing experience with international justice initiatives. In a later post, I'll try to address these individual claims in more detail, but I think it's fair to say that the evidence for each of them is at best mixed and in several cases based on little more than the hope that beneficial consequences will follow from good intentions.


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A DARRENER who has attended almost all the town council's meetings since it was established, has decided to try for a 'comfortable seat' at the next elections.
Ex-farmer David Horsfield said he will put himself forward as an independent candidate for the next town council elections.
It would see the Grafton Court resident, if he stood in his local Sunnyhurst ward, trying to oust one of Labour incumbents David Smith, Brian Taylor or Pete Hollings.
Mr Horsfield said: "I am virtually the only person who attends nearly all the town council meetings. I have been to more meetings than most of the members, so I might as well try to get a comfortable seat!"
Mr Horsfield said the final straw came when he was 'laughed at' during this month's meeting when he was trying to make a point about leaves being blown by borough council workers into the paddling pool in Sunnyhurst Wood.
He said: "Council members shouted me down and told me it was nothing to do with them.
"And yet they have happily thrown £12,000 at improving the place, not that it has done much good."
Mr Horsfield regularly speaks out at the end of council meetings when the public are invited to speak.
He said: "The council is supposed to be welcoming and ready to listen. But if they don't like what they are hearing, some of them just shout or laugh."
Mr Horsfield said he hoped other like-minded townsfolk would consider challenging for a town council seat.
He said: "It is time we had a town council that can stand up to Blackburn.
"That was the original idea and that is what sold it to voters. It is time we did something about it."


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The U.S. Defense Security Cooperation Agency (DSCA) notified a potential sale to Sweden of 15 Sikorsky UH-60M Black Hawk helicopters. Estimated at a value of $546 million, the request also covers 34 General Electric T700-GE-701D turboshaft engines and 15 defensive aid sets, each comprising AAR-57(V)3 missile warning, APR-39 radar warning and AVR-2B laser warning systems.
If it proceeds, this deal will run alongside procurement of the NH-90 (HKP 14) helicopter, for which Sweden signed a contract in 2001 for 18 high-cabin versions (plus seven options), including 13 tactical troop transport/SAR versions. Saab was nominated as the subcontractor to NH Industries for systems integration. However, the program has been seriously delayed, with only five NH-90s delivered for trials and basic training. In the meantime, Sweden has a large force in Afghanistan, operating from Mazar-i-Sharif in the north of the country as part of ISAF. Earlier this year, Sweden urgently ordered AAI Shadow 200 UAVs to support the force, and now helicopter support for these troops is seen as an urgent requirement.
The Swedish defense minister previewed a decision to seek another medium-lift helicopter at an airpower symposium at Malmen last June. The capability is needed by 2013 to address the current shortfall in CSAR and medevac capability, as well as dramatically increase airlift capacity.
The Swedish defense material agency, FMV, said that any new helicopter deal does not affect the NH-90 procurement, although the likelihood of the seven options being exercised appears to be reduced. According to a renegotiated schedule, Sweden should start receiving fully mission-capable NH-90s in 2012, for operational duty in 2014.


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This giveaway is now closed. Thanks!
Katy Jones, Brioni Greenberg, Tacha Brucher and John Q. Adams, the wonders behind the ever-popular Fat Quarterly quilting e-Zine, have a new book for you!
Fat Quarterly Shape Workshop for Quilters includes 60 quilt blocks, 12 quilts and projects and lots of good information for all quilters. If you're anywhere from a relative beginner to a very experienced quilter you'll find something to love in Fat Quarterly Shape Workshop for Quilters.
Orange Soda Quilt by Katy Jones
Each section of the book focuses on a shape: triangles, stars, diamonds, squares + rectangles, circles and polygons. We love the consistent use of fabrics throughout the various block visuals, and how each of the four authors contributes something unique to each shape section. We think the book would be the perfect support for traditional or online quilting bees, as well as an all-around great resource to have at your fingertips any time.
Cub Crawl Baby Quilt by John Q. Adams
We have one FREE block pattern from the book for you to download and enjoy today. Get your free copy of the Courtyard Garden Block designed by John Adams! You can also comment to win one of TWO copies of Fat Quarterly Shape Workshop for Quilters. Tell us about you and quilting… Do you love traditional designs? Is modern where it's at for you? Are you just starting out? Have you quilted since you were little? Are you super-excited about the new Fat Quarterly book?!
There are still tons of tour dates left with lots more information about Fat Quarterly Shape Workshop for Quilters. Several stops will offer up a new, free block pattern and many of the stops also include a new chance to win the book. Take a look!
- 6/12 ~
- 6/14 ~
6/18 ~ Sarah Fielke's The Last Piece
6/22 ~ Fat Quarter Shop
6/26 ~ Diary of a Quilter
6/28 ~ Amy's Creative Side
7/3 ~ A La Mode Fabric
7/6 ~ It's Sew Kiki!
7/10 ~ Craft Buds!
7/12 ~ Craft Foxes
7/16 ~ {sew} Allegorical
7/18 ~ FatQuarterly.com
» Contests & Giveaways, Products, Sewing Tutorials + Patterns » Fat Quarterly Shape Workshop for Quilters...
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189 Responses to Fat Quarterly Shape Workshop for Quilters ~ Free Block Pattern
Thanks for the chance to win this book! Love finding new ideas for quilts and such!
I have been sewing for about 1.5 yes. I love modern designs and classic blocks
I'm new to quilting so I haven't found my exact style yet. But I love these quilts that you showed here. And I like exact pieces not abstract. Thanks for a chance to win! 🙂
I'm an intermediate quilter and do mostly traditional, but I'm trying to break out of my shell and use more brighter colors. The book preview is inspiring!
I am becoming a modern quilter after about 15 years as a traditional quilter. I think that I like the no rules, no judgment, do what you want to do and love it approach to modern.
I have been quilting for alot of years and enjoy the people that come with it. What a beautiful day it is! Thanks for the chance to win this great book!
I love traditional blocks done in a modern way. This book looks like it will be an excellent addition to the library!
I like the fresh colors and prints of modern but some of the traditional block designs, mainly geometric. I'm not a fan of abstract quilt designs.
i love quilts any way they come. i have been quilting for 14 years. quilting blesses the world around me and me too. thanks for a chance to win this book. it looks awesome. janita
I have been a sewer/Quilter for a very long time.I LOVE modern fabrics used in traditional blocks.thanks for the chance to win a fabulous book.
Quilting became a passion several years ago…started out traditional but am now heading straight on into modern. Love the book. Thanks for the opportunity to win it!
I like symmetry, so I do enjoy a traditional block. However, I love a well-balanced modern look too. I love the bright new patterns. I'm fairly new to quilting. I've flipped through the book and it's beautiful!
I have not a clue how you can pick a winner from all this. I have been quilting about 5 years. I love the idea of leaving things to my grandchildren in years to come. I pray it will be pasted down to family to fmmily….Having said that all I can say is I like the book and would love to win a copy…..Thank You!
I tend to prefer traditional blocks. I love the look of modern quilts, but as a relatively new quilter I am still intimidated by some of the shapes and techniques. I think I could learn a lot from this book!
I've only been quilting 2 years but ilove both traditional and modern quilt patterns, but lean more towards modern fabrics.
I've been quilting for over 20 years, starting out very traditional, civil war, primitive. Today, I'm president of our local modern quilt guild. What a journey!
i'm into modern quilting, which i think can be done with traditional patterns as well, and i'm very excited about this book!
I like traditional blocks with modern colors and fabrics.
I get inspired by modern quilt designs and colors, but I have a lot of respect for the traditional quilts. I'm just starting out and I think this book looks FABULOUS!
I took my first quilting class 20 years ago! I love the fresh, clean look of modern quilts. The book looks awesome! Sure hope I win! :0
I'm enjoying the movement of modern quilting and large square blocks. When I was younger, I thought quilts had to be precisely tiny snippets but now the larger the pieces the more colour and original fabric peeks through. Currently embarking on the Swoon!
Looks like a great book. I´ve been quilting about 20 years, using some traditional designs spiked up with bright colors. I sew by hand or machine, but for the moment hand quilting everything. My favorite part is mixing colors and designs.
I love scrappy quilts.
I'm a brandnew quilter (working on my first quilt now). I'm not sure whether I like traditional or modern styles more, it's so hard to choose!
I have quilted all types of quilts. What ever happened to catch my eye at the time. Vintage, traditional, modern, reproduction, civil war, I love it all.
I finally feel as if quilting, although I loved it before, has spoken directly to me with this modern quilt movement. I am humbled by the remarkable talented young and young at heart quilters that share so openly and willingly. Wow!!
I love combining traditional patterns for quilt blocks with bold, modern fabrics!
Newbie quilter! Would love to win 🙂
I don't think I've ever met a quilt I didn't like. My favorites tend to be two colors and very graphic, or lots of colors and prints all jumbled together, like a charm quilt, or Log Cabin or Pineapple scrap quilts.
I've been quilting for about 11 years, since just before my first daughter was born. I wanted her to have a baby quilt and there was no one in my family to do it for me, so I had to learn how. 🙂
I'm just a beginner at quilting, but I find I'm willing to try anything at least once as far as block design, whether it's machine pieced, hand pieced, paper pieced, I'll try it! Traditional, modern, doesn't matter. I only have to make one block to find out if I would like to make multiples. I am really enjoying the process! Thank you for the free block pattern!
I love traditonal quilting and my daughter loves modern so sometmies we do a mix of it together. thanks!
I have been quilting since May 2011, so I'm pretty new to all this, but I have already sewn about 20 quilttops so far and noone can stop me 🙂
It's not that I am into traditional or modern patterns. It's always a matter of the fabrics that you choose (at least that's what I think…) each and every pattern can look tradidtional when using "traditional looking" fabrics, isn't it?
I love bright and intense colors – that makes quilts almost always look kinda modern, right?
I dig into all sorts of literature about quilting that I can get, I loooove all new books that are published – they light up my breaks at work 😉 (reading about quilting for 5 minutes gives me the power to work for yet another two exhausting yet boring hours…)
Thanks for the chance to win this book!
Modern quilting is more to my taste. I did not grow up within a quilting tradition, but came to love it rather recently, only a few years ago. Love all the wonderful range of fabric patterns available, it is one of the best parts about quilting, the lovely fabric choices.
I am the daughter of a long-time quilter but g did not take it up until several years ago. I love it but do have a hard time juggling it between kids and work and exercise;) I'm very excited about this book – I'm holding out until after my birthday to buy it (in hopes that I get it as a gift). I love modern quilting but also like the cottage/shabby chic looking quilts too.
Very fun give away! Thanks for the try. I am both modern and traditional. I love 30's fabrics and patterns and the new stuff. Send help!
I was crazy about modern blocks when I first started sewing three years ago, but now I love the results when I pair modern fabrics with traditional blocks and patterns. Thanks so much for the giveaway!
I love both traditional and modern quilting, and usually end up making things that are a mixture of both. Thanks!
I love handpiecing the most. Probalbly I am more a traditional quilter, but I love all those modern ones too.
I'm a quilter for about 10 years and use traditional block designs but with modern fabrics and lots of color.
That looks like a great book! Thanks for the chance.
beautiful quilts!
i'm just starting out, so, i'm not sure where my quilting lies. i do like both modern and traditional!
My great aunt taught me to quilt when I was 18. My first quilt was made with polyester fabric from the GC Murphy 5 and 10 cent store. We cut the pieces out with scissors using cardboard templates. Mildred would be amazed with rotary cutters and all of the other advances in quilting. I mostly piece my quilts with fabrics I have collected over 30+ years of quilting.
I've been sewing for awhile, but I just started to quilt. And I LOVE it!
I love this new book and would enjoy owning a copy.
I have a few projects in the works, but I am always looking for new ones.
I am a transitional quilter – I like many of the traditional patterns but in modern fabrics and usually in a larger scale.
I am actually super excited about the book, they do really fun work. I have been sewing/quilting on and off for about 6 years but I don't stay doing one type of technique. I also do needlework, crochet, etc. I have all the supplies to learn to paint and inks and stamps for fabric play. I love all styles and go from traditional to art quilt to thread sketch. I keep trying it all and I so LOVE it.
I am a contemporary quilter as I love clean simple elegant lines
I have only recently started doing quilting and so far it has all been handpieced work too. I love hand stitching dresden plates and hexagons. Thank you for a great giveaway.
I like all sorts of quilting, a mix of modern and traditional is great IMO, new twists on classics!
Great giveaway!
I love traditional quilts (and fav fabrics are 30s, 1800s and batiks) but I've done a few art quilts and some with a very modern twist–guess I just like it all!
I've been quilting just over half a year, and love the modern quilting movement!
I am new to quilting. I really, really, really want to win this book. I like traditional quilts with either feedsack fabrics or modern fabrics. I like lots of white in quilts with prints for color.
I've been quilting for what seems like forever and would love to win a copy!
So far, I've only made little things but am getting increasingly inspired by the modern designs. Would love to win this book to get me started! Thanks for the opportunity.
I am new to quilting and love the freedom and improv of modern quilting, so fresh!
I have been dying to get my hands on a copy!
I'd say I'm pretty modern in my quilting but I like to dabble with things outside of my style…
Although I have sewn for years I have just started quilting this year. Love playing with colours and shapes so would enjoy seeing this book
I think I'm new to the world of quilting. The longer I am here, the newer I feel. I love simple quilts, contrasting quilts, and oh my, art quilts.
I like quilts with modern fabric. I've been into quilting for years, but haven't made that many quilts. The book looks very good.
The book looks awesome — I'll definitely need a copy. I have been quilting about 4 years. I just dove in head first and haven't looked back and I love it. Guess I lean more towards modern designs and those with larger pieces. No tiny stuff for my old eyes.
I've been quilting since 2004, and like more traditional quilting (although I've seen some fantastic modern ones, I've also seen some questionable ones). However, I don't like the old fashioned floral fabrics that used to be the norm. I like a lot of the bright colours in modern designs.
So pretty! I still don't know what modern and traditional mean, but I've been quilting since I was 16. No one seems to care which is which when you send them a quilt.
This book looks great! I am a modern quilter with a nod to traditional style.
I think I am going more towards the Moder Blocks but I still love the traditional older blocks. Would love to win a copy of this book, thanks for the opportunity.
I like traditional quilts with fun, modern, colorful fabric!
Im pretty new to quilting. My mom got me into it (I sew clothes) and we are working on a BOM quilt together. I've sewn a mini art quilt and am making a full size for my daighter's birthday.
Been quilting for a while but discovered Modern Quilting about a year ago. Seeing all those beautiful modern quilts really invigorated me. Thanks for the giveaway.
How fun! I love Modern Quilting, but I am just beginning 🙂
I have been quilting quite a while. I am more a traditional quilter. This book looks terrific.
What a great giveaway, I am a modern quilter with a little experience!
I started sewing in Nov '10 and still learning. I love all the modern patterns and colors so I like trying new ideas.
Thanks for an awesome giveaway.
I really want to learn how to quilt. I like both classic and modern styles. Art Quilts look fun.
I'm relatively new (about 6 months) and loving it. Both as a newbie who likes the freedom of imperfection in some designs and as someone who likes to think outside the box on occasion, I tend to be drawn towards more modern quilting, but sometimes that comes out as wanting to use traditional patterns in a more modern way (modern fabrics, modern colours, adding a flare to the overall design). That said, there are some traditional blocks that make me swoon and I can't wait to have a chance to learn some of them. I guess I'm still in the honeymoon "everythng-is-amazing" phase, because I love it all.
I love both 🙂
Thanks for the chance to win .
A dear friend introduced me to quilting about 5 years ago. I love all quilts modern, traditional, art quilts. The book looks fantastic!
what a great giveaway…. Love those quilts
Great book!
wow beautiful book. I'm quiling since 15 years now, love traditionnal and appliqué quilt! love the bright colors. thank's for the chance to win
I'm always drawn to traditional blocks but I like to do them in bright, modern fabrics, ala Material Obsession.
I've been mostly a traditional quilter although more and more I am drawn to more modern quilts — something about the clean lines and negative space that is so fun to highlight fantastic fabrics! So I guess as far as quilting goes, I'm a mutt!!
I'm still a beginner and I love modern designs! Modern all the way for me!!
Book looks so beautiful. Can't wait to take a deeper look inside.
Modern is very me, although I do have a soft spot for old paper pieced hexagon patterns.
I consider myself more of a modern quilter, but I do like some of the traditional blocks. I've been quilting off and on for the last 13 years–the last three of which have been more on than off.
My mother has quilted for more than 65 years and there is a history of quilters on both sides of my family. I started quilting in earnest about 5 years ago. When I taught high school geometry, my mother's quilts became props for teaching about angles and polygons. The students loved being able to touch the quilts and trace designs with their fingers. I digress. I want this book. I'm both a traditional and modern quilter – good at the geometry though color challenged. Thanks for the chance.
I like both modern and traditional quilts. This looks like an interesting book. Thanks for the chance to win a copy.
I'm a beginning quilter and so far seem to be attracted to a bit of modern and a bit of traditional. Just depends!
I'm so excited to hear more about this book. It sounds so informative and inspiring. I've been quilting off and on for more than 20 years. My background is more traditional and I love all the history. Last summer I started reading blogs and learning more about the online quilting community. Boy, were my eyes opened! There is so many talented and inspiring people doing amazing things and I'm loving it all. At first I wasn't too sure about "modern" quilting but there is alot I like.
Thank you for a super giveaway and a chance to win an amazing book.
Two copies! So Generous!
I've finally have a crafting space and would love to dive into a quilt making project. These look really interesting. I can't wait to try one out!
I have beening quilting for nearly 20 years now. Although I have been drawn to traditional quilts, the modern ones are now calling to me. I love the designs and the bursts of color.
This book would be a great addition to my library. Thank you for the pattern!
A great book, two great quilts and a darling little girl from the back! Cross fingers1
I am a fairly new quilter but I love traditional blocks done with modern fabrics!
I've been quilting for many, many years, modern and improvised is my passion and I am very excited to see the new book…even better if I won it 🙂
I like modern and traditional quilting. Taught myself how to quilt as a teenager by doing it and reading books.
Meet John last week at the Fat Quarterly Retreat in London. The only other guy there and we had a great time.
My mom taught me to Quilt about 8 years ago. Once I started I was hooked. More of a modern quilter but I am open to all types of work. Like working with shapes, colors and prints when planning out my projects.
I am a traditional quilter, but love the new modern fabrics. This book looks awesome. Thanks for sharing a copy!
That book looks fantastic! I'm inexplicably drawn to triangles and hexagons; it'd be good to break free of them some time!
The book looks fabulous!! I've migrated to mostly modern designs (and solids), am in love with my HandiQuilter, and need some design ideas to help me whittle my stash down a little :). (so that I can buy more fabric, of course!). Thanks for the contest!
I consider my quilting style to be "modern traditional" 🙂
I've been quilting 12 or so years and love the trad and mod designs! This book looks great from what I've seen of it, thanks for the chance!
This looks like a fantastic book. Thanks for the chance! I have been quilting for about a year now and sewed home goods before that. I was drawn to modern quilting because of my love of color and contemporary fabrics.
I'm a more traditional quilter and haven't made anything 'modern' yet. But the more I'm seeing modern quilts the more it's making me want to try one. Thanks for the great giveaway.
I have been quilting for a long time but am really wanting to get more into it as my children are much older now. The Modern Quilt Guild was made for me. I'd love to add this book to my library.
I am a brand new quilter, just now working on my very first quilt, and I'm LOVING it so far!!! (Not that I'm making anything super-amazing-fantastic, just having fun with it) I would sure love to win that book, to get me started a bit better!! 🙂
I've been quilting for a long time, but discovered modern quilting in the last few months and it has totally refreshed my interest.
I am excited about the book, definitely! The FQ gang are just so much fun. I like a mix of modern and traditional, but am lately just drawn to improv. I like to make it up as I go. I love trying new-to-me techniques, too! And I've only considered myself a quilter for about a year. I learned to sew when I was a kid, though.
I've only made a few baby patchwork quilts, but I'm gathering up the courage to make something larger with "real" blocks. I much prefer modern quilts, but there are a few great traditional styles that I like, such as windowpane quilts.
I do love traditional quilt patterns!
Great contest, would love to have this new book. Love the blog!
I'm just starting out, so I don't have a ton of exposure to different quilt blocks. But I will say that so far I like traditional blocks or when people take modern twists with them. Thanks for a chance to win though, this book looks awesome!
I'm new to quilting. I made my nephew a quilt. It was so much fun. I love the look of the traditional patterns but love the modern for my home.
I am a thirty something who started quilting 4 years ago and immediately became addicted. My mother and I just started a longarm quilting business in March. My style is non traditional. I like fun bright and fresh fabric patterns. I just signed up for two block swaps on line so this book would be perfect!!
I'd say that my style is somewhat traditional but I do enjoy using the modern fabrics. Thanks for the giveaway!
I want to win this book, it looks great.
Costa Rica
I've been quilting for about 10 years, and I love traditional and modern quilting. I still feel somewhat like a beginner, since I've only actually finished 3 quilts. Many more to come, but right now they're mostly in my head.
I like the traditional patterns with new fabric.
I'm just starting out with quilts for my girls' beds and would love to learn some new things! That block looks fabulous!
I've only made 3 quilts. I'd like to learn to do something other than squares or rectangles. This looks like a great book.
I am just starting out but much prefer the traditional quilts. I am very excited about this book – I think I could learn a lot from it.
I think I just started quilting as I didn't make many quilts by now. But I learned so much by reading blogs and of course making quilts. My style is – I think – something between traditional and modern.
I'm somewhat new to quilting and like to try out different patterns. I think this book will be a lot of fun…especially the orange soda quilt pattern.
I'm a big fan of modern quilting and am just starting out. This book looks like a wonderful resource!
I'm starting to find my own style in quilting (and up my game in harder to piece blocks), which means looking up all kinds of blocks for inspiration. This looks like a fun book to go through!
Just finished my first quilt and I love seeing such inspirational projects! They totally motivate me to get started on my next project.
I love doing traditional work with modern prints or modern flair 🙂
It does look like a great book; thanks for chance to win! I've been quilting about 5 years, some traditional patterns, some a little improvised, but lots of "modern" fabrics used. I love to make baby quilts as gifts and there are so many fun fabrics for that!
i lean towards modern blocks and shapes and love applique, but i try to pick quilts that have a new-to-me technique. i'm still learning and have been quilting 3 of the last five years or so. i've a few books, each about something different in quilting. this book would fit my criteria! thanx for the opportunity to win it.
I've only been quilting for about a year now, but I'm drawn to modern patterns. I still need lots of practice making them come out right though!
I love the modern quilts – particularly those made with all solids. I just haven't really made many myself yet! Thanks for the giveaway!
I am relatively new to quilting but I really love it. I do a blend of modern and traditional. Traditional patterns adapted to have a modern feel through color choice or paring down a design. I am very excited about this because I have started working with shapes and am super excited about triangles at the moment!
Just getting back into sewing. This is a wonderful site! And giveaways too! Thanks
I enjoy quilting and I always have a variety of projects in various steps along the way to becoming a quilt. I enjoy modern and traditional and I have a special fondness for applique.
I'm just learning to quilt, I've finished a very basic baby quilt and am at the point where I need to bind my second slightly less basic baby quilt. I love the traditional patterns but am a big fan of bright modern colors so I am drawn to incorporating both.
I just started quilting again after about 3 years. I just got a new sewing machine and am now in the process of making a quilt for my nephew's wedding. I live bright bold modern designs. thanks!
Hi! I've quilted for decades, but if I have to say how many, you'll know I'm OLD! But I can change my ways. I've gone from thoroughly traditional quilting with dull, muddy fabrics, to slightly liberated quilting with clear, bright and solid fabrics. Thank you for the chance to win that book so I can continue to change my ways.
I've only been quilting for a little over a year now, so I'm still pretty green 🙂 I love more modern quilts and prints usually. Thanks for the giveaway!
What a colorful, charming book! My favorite quilt was the story quilt I made while taking classes at Hiram Weekend College in Hiram, Ohio. With the encouragement of my instructors, my story quilt told of my life-long desire to pursue my forever dream of attending college there & graduating at the age of 58!!
I love traditional quilt shapes, but I am eager to branch out. I love to hand quilt.
Would love a copy of this book! Getting a bit bored of trying to modernise just the basic courtyard steps and stars. I just started quilting this year and I'm amazed by how satisfying it is, particularly compared to garment sewing which is an exercise in despair half the time for me.
I know this has to be a great book. I was a subscriber to Fat Quarterly until it ran out and I haven't renewed again yet. They had such a great variety of quilts and other things so I know that book must be awesome.
Thank you for the block.
Just starting to quilt! On my second quilt!
What a great giveaway!
I'm still new to quilting, but I love the look of modern quilts.
I'm a "old" sewer but a new quilter. I was never interested in quilting until I recently started seeing modern quilting. Now I'm giving it a try! Thanks for the chance to win!
I am just starting my first quilt out of fat quarters..I am excited go see how it turns out. Sounds like a fun book.I would be pleased to have book with different ideas.
This book looks fun! I want to try everything so, I tend to do both modern and traditional. I haven't really settled on a style yet. I learned to quilt about 15 years ago. I only really got into the craft a few years ago when I began reteaching/remembering how to quilt.
I like clean design, so I lean toward modern quilting but like both. I've been sewing for years but only in last two years started quilting in part because of all the wonderful fabrics, great inspiration, and tutorials on sites like yours.
would love to win this book, i've made a couple of simple checkerboard style quilts, but would love to branch out and make some funky modern blocks and put them all together for a quilt
I'm fairly new to quilting. I have a few quilts under my belt, and am looking to expand my knowledge on different shapes and blocks. I love modern quilting with a touch of traditional!
I'm new to quilting and tend to like more modern designs. I have no experience with sewing curved pieces – but I love seeing them on other people's work. I'm always inspired by what others do! Thanks for sharing the book.
I love modern quilting and bright colours. That Orange Soda quilt is right up my alley!
I aspirationally quilt more than I do in real life these days, with two young kids and a work schedule. I hadn't been so into this book because the glimpses I'd seen made it look fairly traditional (complex pieced blocks) but I love the baby quilt pictured here, that mixes blocks with strips — that looks like such a clean-lined, elegant and modern design which also (helpfully!) cuts down on the time to make a hand-made item. Saved for the file…and it makes me hope to win the book! Thanks for the giveaway!
What a great book! I've been quilting since I was a kid and now I'm trying to push myself into a more modern style. We'll see how it goes!
looks like a great book! i aim more towards modern fabrics but i like both mod and traditional piecing.
I am just learning, but I really like modern quilts.
In terms of quilting I'm a newbie. I learned how to quilt in fall 2010 and I've made a few small projects since then and am working on my first full sized quilt currently. I have multiple projects lined up after that. I'm definitely more intrigued by modern quilting designs over the more traditional ones though.
This is so awesome! I am a beginning quilter, and I would love to do some of this stuff!
I'm just learning, but I really like modern ones.
I like somewhat traditional blocks with a modern twist & bright fabrics. What I don't care for is making the same block in the same fabrics over & over again. To me it gets a bit boring & tedious
I'm on year 12 of being a beginner. I've broken free of traditional quilting. Well sort of, because I still love a pinwheel quilt other patterns if they are a little unique.
Fun book, thanks for the giveaway!
I'm just starting out quilting. I have my first baby on the way and am planning on making a quilt for him or her!!
I love modern quilting, I am so excited about this book I was at the FQ Retreat last weekend and they had books in the raffle but I didn't win 🙁 So I would love to have a copy from you! thanks for the giveaway
Thanks for the free pattern!
I love modern and improv!
This looks such a great book!
The book looks fabulous. I am finding more and more that traditional patterns look, just that…traditional, and am being very attracted to more modern designs. I learned to sew, patchwork, crochet and quilt when I was little, but have had little time to pursue much as I worked and raised a child. Now I have more time, and I do many creative things. Most of the quilted things I make now are small…fabric postcards, mugrugs, and other small quilts.
I am just starting out, but I tend toward traditional patterns made with colorful fabrics.
Thanks for the chance!
I just purchased the book – but my daughter would love a copy!
Hi, I am a quilter of about 5 years now but I am also a caregiver and time to quilt is not as easy to find anymore. In the past I have kept busy with traditional patterns and blocks but have a new love interest in the modern quilts–I love how fresh and energetic they are. Thank you for allowing me to see many of the beautiful fabrics available and to read what is happening in the modern quilting world.
I've only made one quilt – and that was a simple strip quilt. I think I like the more modern designs, I'm on the look out for some ideas for my next project
Love that riot of color on the Orange Soda quilt! Seeing that on my bed would make me smile every time I saw it.
I've made a few quilts – one for each of my sons, one for my dad and one for my sister. Mostly just straight lines or patchwork. I'd like to branch out, but I do prefer basic, clean designs over the really complicated ones. I'm really loving that baby quilt in the photo above!!!
I would love to start quilting but it looks so time consuming and my girls barely let me sew as it is.
I'm new to quilting, but have been sewing since I was in middle school. At this point, I lean more towards the traditional designs. The book looks like a great resource!
I have been quilting for 5 years, and am currently balancing several "mommy, I wants" with guilt over not doing anything for the one kid who can't yet talk. I tend towards the more traditional designs. And I love the Fat Quarterly e-zine and am very excited about the book!
I would love to win a copy of the book!
I just started working on my first full size (twin) quilt. I love the more modern style, and modern fabric lines.
I usually do traditional designs but SO want to start trying modern!
I love modern quilting, but the longer I quilt the more I'm fascinated by traditional designs and quilt history, too.
Wow! Thanks gor the great give away! I quilt using bright clear colors and would say Modern is my style. Though I love solids, I tend to sew scrappy using mainly Kaffe, Amy, and such. Stitching quilts has been my main focus for about thirty years, and my stash is ever evolving.
That block is so fun!
I've been quilting for 2o years, getting my start as a teenager with some quilts my mum started before I was born! While I live traditional stuff I'm definitely a modern quilter.
I'm pretty new to quilting. I've read a ton of books but I'm just finishing my first quilt. I'm in love! Quilting is amazing!
I have quilted since I was 10 years old but I feel like I am always learning something new.
I'm a novice quilter and I like the modern designs. I like asymmetrical designs the best. I'd love to win this book.
I'm a new quilter, and I'm all about modern and straightforward. I quilt to relieve stress from work and grad school!
I'm new to quilting so would love to win this book. It looks fantastic! Thanks for the chance and the block!
This looks like a great book. I would love to win. Thanks
I like easy desings that look like work lol. I'm BRAND new to quilting and still scared to piece and finish
What an awesome beautiful book!
I am just a beginner and I love reading your blog, so inspiring! I love traditional quilting and blocks such as FWs ones but I don't use vintage fabrics, I prefer Lecien florals instead. Thank you very much for sharing so many tutorials, I really appreciate that as a beginner!
Oh, what a great giveaway. Promising myself extra quilting time this summer, and these would be great!
« Modern Block of the Month Highlights Winners: Summer Reinvention Challenge + Book Giveaway »


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Set amid varied countryside, the well-signposted 185km St. Boniface Route takes in fascinating places of interest as it makes its way from Mainz to Fulda, two episcopal cities with impressive cathedrals. .
Boniface, born to a noble family in Wessex in 672 or 675 and originally named Wynfreth, was one of the most important preachers and reformers of the early Middle Ages. Even today, many things still recall this Benedictine monk and bear his name. A fascinating trail with plenty of places where pilgrim records can be stamped, the St. Boniface Route is ideal for walkers and modern-day pilgrims. It retraces the path taken by the medieval funeral procession that carried the body of the missionary and church reformer Boniface, who was greatly mourned by the people, from Mainz to his final resting place in Fulda in 754. Along the way, pilgrims can enjoy a variety of scenery including gently rolling vineyards and open plains that give way to densely wooded hills and meandering valleys. Pilgrims will also pass a series of stone monuments to Christian culture, from tranquil abbeys and old country chapels to stone crosses, wayside shrines and romantic village churches. Cities, towns, pretty villages and a number of impressive buildings dating from the Romanesque through to the Gothic and baroque eras stand as reminders of the region's rich and turbulent history. All of the cities, towns and villages along the route are well served by public transport and offer a range of accommodation.
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Web Content, Digital Assets, Form Builder, SEO Tools, Decision Support
Multisite Management, Multilingual Support, Site Synchronization, Deployment Options, Security, Scalability
Personalization, Email Marketing, Mobile, Social Media, Analytics
Integration Platform, Connector for Salesforce, Connector for Microsoft Dynamics CRM, Connector for Marketo, Connector for SharePoint
Product Catalogs, Multiple Storefronts, Targeted Offers, Payment Processing, Order Management
Custom Content Types, UI Framework, ASP.NET MVC Support, Visual Studio Support, Comprehensive API
Behaviour Tracking, Data Integration, 360° Customer Profile
Audience Segmentation, Predictive Analytics, Campaign Recommendations, Campaign Tracking
Marketing Attribution, Conversion Tracking, Persona Profiling, Lead Scoring
Predictive Personalization, Persona-Based Targeting
I have a multi selection list box in one of my custom widget designers. I would like the selected values form this list box to be saved as a list of guid to my controller's property. I cant seem to find any example for this. I have tried to get the selected values from the list box as a java script array and assign it to the Controller property but it doesn't work.
=====Custom Widget designer ascx file=======
<select size="4" multiple="multiple" id="NewsTypes" class="rss-listbox valid">
<option value="63ae86cc-3500-6b76-8c45-ff00006d12a1">Internal News</option>
<option value="96ae86cc-3500-6b76-8c45-ff00006d12a1">External News</option>
======= Custom Widget designer JS file======================
applyChanges: function () {
var controlData = this._propertyEditor.get_control();
var array = [];
jQuery('select.rss-listbox :selected').each(function (i, selected) {
array[i] = jQuery(selected).val();
controlData.NewsTypes = array;
=====Custom widget Controller =============
[Category("Table Data")]
public List<Guid> NewsTypes { get; set; }
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The Agency of Water: Scarcity, Abundance, and Design in Dialog
Tuesday, Feb 15, 20117:26 PMEDT
The Arid Lands Institute upcoming event (Tuesday Feb. 15) is sponsored by the Metropolitan Water District of Southern California. We are very pleased to have brought together 2 really interesting thinkers on the urban water crisis worldwide-both flooding and droughtand we are proud to have the west's largest water utility sponsoring the event. Information about the lecture follows: As part of ALI's ongoing Excavating Innovation lecture series, please join us for presentations + discussion: Tuesday February 15th at 7:00 pm in the Ahmanson Main Space, Woodbury University. The Agency of Water: Scarcity, Abundance, and Design in Dialog Vinayak Bharne Urbanism, Infrastructure & the Urban Water Crisis: Perspectives from Asia & the American Southwest Dilip da Cunha Negotiated Landscapes: Mississippi, Bangalore, and Mumbai Vinayak Bharne, a practicing urban designer and planner, teaches at the University of Southern California in Los Angeles. His work has focused on the critical conservation and reuse of indigenous infrastructures as catalysts for sustainable urban growth and development, with ongoing projects in Iran, India and the American southwest. He is a contributing author of Los Angeles: Building the Polycentric Region (2005), and the forthcoming Aesthetics of Sustainable Architecture (mid 2011). Dilip da Cunha, an architect and planner, serves on the faculty of Parsons School of Design, New York and the University of Pennsylvania. With Anuradha Mathur, his work has focused on cultural and ecological dimensions of contentious landscapes, wet and dry. His work includes Mississippi Floods: Designing a Shifting Landscape (2001); Deccan Traverses: the Making of Bangalore's Terrain (2006); and SOAK: Mumbai in an Estuary (2009). Hadley Arnold, co-director of the Arid Lands Institute, will moderate a discussion on water infrastructure, design strategy, and the public realm. For more information, see: http://aridlands.woodbury.edu/lectures/bharne_dacunha.html ARID LANDS INSTITUTE Woodbury University 7500 Glenoaks Boulevard Burbank, CA 91510 818. 394 3335 T 818. 767 8851 F firstname.lastname@example.com www.aridlands.woodbury.edu
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I have had silicone implants for 20 years. It was a stupid decision of a 20 year old girl.
Although they looked fantastic and natural from day one I started having strange aches and pains in differnt area of my body about 5 years ago. Blood test over the last 3 years have showed that I have a disease associated with the Immune system but further tests to see what disease I have gave all negative results (Lupus, Arthritis, Etc...) I finally had a breast MRI which showed that although the implants were not ruptured they WERE BLEEDING Silicone. All my lymph nodes that are close to the implants are all extremely enlarged. I also just had a sonogram of the chest and the technician told me of patients she sees where silicone has leaked all around the heart.
It is horrible that the truth is not told about what does happen to many womem with these implants. They should not be on the market.
Can anyone recommend a great surgeon for removal in NYC or Palm Beach Area? Thanks.


text: The centerpiece of our 7-acre island property, which has been designated a 'Green Lodging' facility in recognition of our diligent conservation practices, is our oversized pool. As with all our common areas, our pool and its surroundings are meticulously maintained. It also offers a magnificent view of the Gulf, easy access to our outdoor Blue Bar, and a welcoming path to our private tanning beach.


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Washington State
- 3 total posts
- 3 comments
Recent comments from Washington State
If any of you have ever paid for good skin care you will realize the price of this is in range with what the other charge. They say when you get older you should wear less make-up and this product is great for that. I have been able to... READ COMMENT
I love the stuff and I have used Mary Kay since I was 18 now 50 and I was looking for something new. Mary Kay was great. If you price any skin care it will cost $$ and as for the membership it is nice to know that I will not run out and... READ COMMENT
I order the product and am very happy with it. The smell is not so bad and if you would have read all the paper work that came with it you would be ok. I called them the day I got the product and asked them about the club I joined (did... READ COMMENT


text: Members of the Missouri Board of Registration for the Healing Arts said state law made it difficult for them to keep the public safe from dangerous doctors. Soon, they may have a state law that gives them a little more muscle. On Friday, the Missouri Legislature sent Gov. Jay Nixon a bill that would give the board more power to suspend incompetent and impaired doctors and provide patients with more information about their doctors. The reforms were inspired by a Post-Dispatch investigation last year that found the state's policing of doctors to be among the nation's most lax and least transparent. Nixon said he was still reviewing the bill but said it was "a step forward in clarifying and strengthening many sections of the law to help better discipline bad doctors and improve patient safety." If the governor signs the bill, it will take effect Aug. 28.


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C Notes: TLC 'CrazySexyCool'
Here in the office, I made the bold claim that TLC is the greatest* R&B girl group of all time…*Well, in my lifetime. I know there are groups like the Supremes and En Vogue, and Destiny's Child is often given the title of "best" based on their record sales. But T-Boz, Left Eye and Chili were always special. Not only was the trio authentic, they always seemed to have a message in their music and continually stood for girl power. A few dope songs off their 1994 crossover classic, CrazySexyCool.
"Red Light Special"


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"Classic Lube Express is proud to announce that they have been in business for over 15 years and have been blessed with the very same management team since day one!"
Mission Statement
Classic Lube Express is dedicated to providing our customers with the best oil change service they have ever experienced. We focus on incredible customer service, quality work and efficient speed.
Classic Lube Express is a friendly and locally owned business. We offer a variety of products and services, including environmentally friendly oil, to help keep your car maintained. We thrive on our core principles of honesty, integrity, and safety. Stop by and experience the difference.


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This is actually a pretty neat idea. It would be nice if someone came out with a solution like this for WinMo phones. I could finally use a small device that has a keyboard and could do all the features my Harmony can (kind of). Maybe Logitech should release something like this instead of a new remote (since they don't seem to be adding a keyboard to their remotes anytime soon).
How was the response time? I've set my cell up for wireless control using webguide before, but the delay time sucked. It was like 2-3 seconds from the time I hit a button to the time it happened on the TV.


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Botsford News Release
Farmington Hills, Mich. (September 5, 2013)---Zachary J. Baselle, D.O., has joined the medical staff at Botsford Hospital in Farmington Hills. As a member of Farmington Emergency Medical Associates, PLC, Dr. Baselle is among the 19 specially-trained physicians who diagnose and treat patients in Botsford's Emergency and Trauma Center.
After graduating from A.T. Still University's Kirksville College of Osteopathic Medicine in Missouri, Dr. Baselle completed his four-year emergency medicine residency at Botsford. During that time, he served as chief resident of emergency medicine and as an EMS lecturer, providing training for paramedics, local fire departments, and paramedic students. As a resident, Dr. Baselle also gave more than 20 lectures to Botsford staff physicians and residents on a variety of topics involving emergency medicine.
Dr. Baselle has delivered medical care to the people of one of the poorest countries in Latin America---Guatemala---during two medical missions. As an undergraduate student at Albion College, he coordinated the building of two Habitat for Humanity homes that allowed two families to break their cycle of poverty. Also while at Albion, he served as the 2005 class president, chaired the student affairs senate, and served as president of his fraternity, Delta Sigma Phi.
Dr. Baselle is a member of the American Osteopathic Association, the Michigan Osteopathic Association, and the American College of Emergency Physicians.
Beaumont Health is Michigan's largest health care system, based on inpatient admissions and net patient revenue. A not-for-profit organization, it was formed in 2014 by Beaumont Health System, Botsford Health Care and Oakwood Healthcare to provide patients with the benefit of greater access to extraordinary, compassionate care, no matter where they live in Southeast Michigan. Beaumont Health consists of eight hospitals with 3,337 beds, 168 outpatient sites, nearly 5,000 physicians and 35,000 employees and about 3,500 volunteers. In 2015, the organization had $4.1 billion in net revenue with 177,934 inpatient admissions, 17,151 births and 530,860 emergency visits. For more information, visit beaumont.org.
botsford.org, twitter, facebook, blog
MEDIA CONTACT: Lynn C. Anderson, Director, Marketing & Public Relations or Beth Montalvo, Publications & Media Relations Coordinator
Download Attachments: BaselleZachary.jpg


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GENEVA (Jul. 19)
Israel has concluded a free-trade pact with the six nations of the European Free Trade Association.
Under the agreement, to be signed by ministers later this year, all duties and barriers to trade among the signatory countries will be abolished.
The pact, which must still be ratified by Israel and the EFTA countries, is expected to be implemented on Jan. 1, 1993, the same date that the 12-nation European Community is scheduled to complete its economic integration.
EFTA unites in one free-trade area the markets of its members, which are Austria, Finland, Iceland, Norway, Sweden and Switzerland.
It was particularly important for the EFTA countries that the agreement be rapidly implemented in order to avoid the negative effects on trade of a new program of tariffs that had been introduced by Israel in September 1991.
The initiative to start negotiations on a free-trade agreement with Israel was taken by EFTA ministers in March 1991. The goal was to provide EFTA countries with the same trading conditions with Israel as those enjoyed by the European Community and U.S. exporters.
Trade volume (imports plus exports) between EFTA countries and Israel totalled almost $1.7 billion in 1991.
Israel's new foreign minister, Shimon Peres, will be in Geneva on Sept. 17 to sign the pact.


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Would a cloud by any other name sell as well?
My last blog entry 'Does Gartner understand cloud computing' generated a lot of interest, especially in the twitter-o-sphere. This was no surprise, as opinions about this space tend to be very mixed. More so, I suspect that there is frustration with vendors, as your average 'web application' gets re-branded as a 'cloud application' and pitched to IT managers as the coolest thing since SOA, Agile Programming, UML, <other technology hype>. Senior IT professionals really just want to understand what the cloud is, without the hype and without any sales pitch.
So to be fair to Gartner, I thought I should take an attempt at my own definition of cloud computing:
"Cloud computing is defined as a self-service environment for the immediate provisioning of platforms and applications, with billing being based on granular usage consumption metrics."
Take a look at the key attributes: self-service, immediate, granular billing. These attributes are really the main difference between cloud computing and any other technology. It's the reason why having a web server is so 2000, while running a server on Amazon's platform is so 2010: Amazon allows you to spin up images by yourself, makes them immediately available and will bill you for CPU, bandwidth and storage on an hourly basis. These limiting attributes are also the reason that cool new technologies can be implemented, such as the LabSlice virtual training environment – pull down training images on a need-be basis and pay solely for usage of the machine on an hourly basis. Very different from the old model of purchasing servers, deploying them in-house and then paying on an ongoing basis for hardware maintenance, usage and upgrades.
So the next time a vendor pitches you on a cloud solution, simply ask them the following:
1. Does your product offer self-service functionality to each and every one of our employees?
2. Is your solution immediately available to be used by each and every one of our employees?
3. Do you offer granular billing, so that we can pay you solely for what we consume?
By Simon Ellis


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Q:Do you all carry the faux wood blinds in 1/2 inch or 1 inch slats?
A:Our faux wood blinds come in either 1 inch, 2 inch or 2 1/2 inch slats. We also carry real wood blinds in three sizes, 1 inch slats, 2 inch slats, and 2 1/2 inch slats. The only window blind that comes in a 1/2 inch slat would be our aluminum micro mini blinds.
There is no such thing as 1/2 inch faux wood blinds. Faux wood blinds are made with a pvc or vinyl material. This material is created with uv inhibitors so that the faux wood blinds resist warping and discoloration, however, the faux wood blind slats would not maintain stability with such a narrow blind slat.
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Our View
Our View
The White Hall School District will no longer have to meet the No Child Left Behind benchmarks known as Adequate Yearly Progress.
On its best day, NCLB was arbitrary and unrealistic. It required that all students achieve grade-level proficiency by 2014 � regardless of their circumstances.
In late June Arkansas was granted flexibility from some longstanding requirements of NCLB, adopted by Congress in 2001. Beginning with this school year there will be one classification system for all schools, using the same measures and indicators.
The NCLB goal of 100 percent proficient has been replaced with a new goal of reducing proficiency gaps by half by 2017.
It is as if common sense has kicked in when it comes to evaluating schools. It also means parents, teachers and administrators must learn a new language when it comes to evaluating progress in the classrooms.
Educators can focus on specific problems unique to each public school in Arkansas. They will still have rigorous standards, but they�ll be more realistic.
The state will continue to hold schools accountable for closing achievement gaps, but schools won�t be subject to a system of increasingly unrealistic annual target of AYP.
Under the waiver the Arkansas Board of Education establishes its own goals for increasing overall student achievement, as well as the achievement of students in demographic subgroups.
Flexibility means multiple counting of students in more than one subgroup � by race, economically disadvantaged and with disabilities, for example, � would be eliminated. Annual benchmarks will be set with the goal of reducing the failure rate in reading and math by 50 percent within six years.
It requires real change in the lowest performing schools, allows for locally-tailored solutions based on individual school needs, and recognizes schools for success.


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NSL Analytical Signs Agreement with LaFleur
September 9, 2003
NSL Analytical Services, Inc. has named LaFleur & Associates, L.L.C. its newest regional technical sales representative. NSL specializes in chemical and metallurgical testing and analysis for the aerospace, ceramic, chemical, general manufacturing and pharmaceutical markets. LaFleur & Associates is a professional field sales agency specializing in high technology industrial marketplaces. This agreement combines NSL's broad laboratory testing capability with LaFleur's analytical expertise to provide a total materials analysis solution. LaFleur's corporate staff in Sarasota will support the Florida territory, while the regional office in eastern Pennsylvania will support select clients in the eastern U.S. and Canada.
For more information, visit http://www.nslanalytical.com .
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