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Research Topics
Genomes and Genes
deficiency diseases
Summary: A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)
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Publications253 found, 100 shown here
- Iodine deficiency, iodine content of salt and knowledge of iodine supplementation in the Dominican RepublicT Malasanos
J Trop Pediatr 53:214-6. 2007
- MLYCD mutation analysis: evidence for protein mistargeting as a cause of MLYCD deficiencyP J Wightman
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh, UK
Hum Mutat 22:288-300. 2003..As none of the three mislocalizing mutations are predicted to alter the catalytic function of the peptide, it seems likely that correct subcellular localization of MLYCD is critical for it to function normally...
- Assessment of iodine status using dried blood spot thyroglobulin: development of reference material and establishment of an international reference range in iodine-sufficient childrenMichael B Zimmermann
Laboratory for Human Nutrition, Swiss Federal Institute of Technology, LFV E19, Schmelzbergstrasse 7, CH 8092 Zurich, Switzerland
J Clin Endocrinol Metab 91:4881-7. 2006..Thyroglobulin (Tg) may be a valuable indicator of improving thyroid function in children after salt iodization. A recently developed Tg assay for use on dried whole blood spots (DBS) makes sampling practical, even in remote areas...
- Effect of Brazil nut supplementation on the blood levels of selenium and glutathione peroxidase in hemodialysis patientsM B Stockler-Pinto
University of Sao Paulo, Faculty of Pharmaceutical Sciences, Sao Paulo, Brazil
Nutrition 26:1065-9. 2010..We evaluated the effect of Brazil nut supplementation on blood levels of Se and glutathione peroxidase (GSH-Px) activity in patients on hemodialysis...
- Nutritional deficiencies in morbidly obese patients: a new form of malnutrition? Part B: mineralsOrit Kaidar-Person
The Bariatric and Metabolic Institute, Section of Minimally Invasive and Endoscopic Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA
Obes Surg 18:1028-34. 2008..In this review, we examine the prevalence and manifestations of various mineral deficiencies in obese patients...
- Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG Interagency Meeting on Zinc Status IndicatorsBruno de Benoist
Department of Nutrition for Health and Development, World Health Organization, Geneva
Food Nutr Bull 28:S480-4. 2007..The prevalence of low serum zinc and inadequate zinc intakes may be used to evaluate their impact on the target population's zinc status...
- Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementationJonathan H Siekmann
Program in International Nutrition, University of California, Davis, CA 95616, USA
J Nutr 133:3972S-3980S. 2003..Supplementation with small amounts of meat or milk reduced the high prevalence of vitamin B-12 deficiency in these children...
- Population spectrum of ACADM genotypes correlated to biochemical phenotypes in newborn screening for medium-chain acyl-CoA dehydrogenase deficiencyEsther M Maier
Research Center, Department of Biochemical Genetics and Molecular Biology, Dr von Hauner Children s Hospital, Ludwig Maximilians University, Munich, Germany
Hum Mutat 25:443-52. 2005..Our data might provide technical and medical guidance for decision making in the worldwide efforts to introduce MCADD population screening...
- Assessment of the trace element status of individuals and populations: the example of zinc and copperChristine Hotz
Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
J Nutr 133:1563S-8S. 2003..Because relatively little information is available on zinc toxicity, the discussion concerning the definition of excess intake of trace elements focused primarily on recent work concerning risk assessment of copper toxicity...
- [Prevention and treatment of deficiency diseases with milk and dairy products]Charles Joël Menkes
Académie nationale de médecine
Bull Acad Natl Med 192:739-47. 2008..Calcium and vitamin D should be systematically added to treatments for patients with established osteoporosis and for those with risk factors...
- Spot urinary iodine concentration as a measure of dietary iodine, evaluated in over 3800 young male subjects undergoing medical check-up preliminary to military enrolment in Piemonte and Aosta Valley (Italy)D Fonzo
Regional Centre for Thyroid Diseases, Department of Endocrinology, Ospedale Mauriziano Umberto I, Torino, Italy
J Endocrinol Invest 26:1186-91. 2003..Further population studies are required...
- Thyroid volume in children: role of iodine intakeP Vitti
J Endocrinol Invest 25:666-7. 2002
- Determining median urinary iodine concentration that indicates adequate iodine intake at population levelFrancois Delange
International Council for Control of Iodine Deficiency Disorders, Brussels, Belgium
Bull World Health Organ 80:633-6. 2002..The study was carried out to determine the frequency distribution of urinary iodine in iodine-replete populations (schoolchildren and adults) and the proportion of concentrations <50 micro g/l...
- Double fortified salt at crossroadsB Sivakumar
Division of Biophysics, National Institute of Nutrition ICMR, Jamai Osmania, Hyderabad, India
Indian J Pediatr 69:617-23. 2002....
- Sustainable control of iodinedeficiency in Iran: beneficial results of the implementation of the mandatory law on salt iodizationF Azizi
Endocrine Research Center, Shaheed Beheshti, University of Medical Sciences, Tehran, I R Iran
J Endocrinol Invest 25:409-13. 2002....
- The elimination of iodine deficiency in the Czech Republic: the steps toward successV Zamrazil
Institute of Endocrinology, Prague, Czech Republic
Thyroid 14:49-56. 2004..Neonatal thyroid screening could constitute the major monitoring tool in order to insure sustainable elimination of iodine deficiency in the Czech Republic...
- Current status of iodine deficiency disorders (IDD) and strategy for its control in IndiaSheila C Vir
UNICEF India Country Office, Lucknow Field Office
Indian J Pediatr 69:589-96. 2002..A two pronged strategy needs to be institutionalized for ensuring continued demand for iodised salt, linked to ongoing health, nutrition and education programmes as well as for ensuring supply of quality iodised salt...
- Iron, zinc and iodide status in Mexican children under 12 years and women 12-49 years of age. A probabilistic national surveySalvador Villalpando
Centro de Investigación en Nutrición y Salud, Instituto Nacional de Salud Publica, Cuernavaca Morelos, Mexico
Salud Publica Mex 45:S520-9. 2003..To describe the epidemiology of iron, zinc and iodide deficiencies in a probabilistic sample of Mexican women and children and explore its association with some dietary and socio-demographic variables...
- Nutritional status of indigenous children at boarding schools in northern MexicoJ Monárrez-Espino
Department of Women s and Children s Health, Uppsala University, Sweden
Eur J Clin Nutr 58:532-40. 2004..To assess the nutritional status of Tarahumara children at indigenous boarding schools...
- Micronutrients and genomic stability: a new paradigm for recommended dietary allowances (RDAs)M Fenech
CSIRO Health Sciences and Nutrition, PO Box 10041, Gouger Street, BC, SA, 5000, Adelaide, Australia
Food Chem Toxicol 40:1113-7. 2002..That there is a need for an international collaborative effort to establish RDAs for genomic stability is self-evident...
- Eliminating iodine deficiency disorders--the role of the International Council in the global partnershipBasil S Hetzel
Children s Health Development Foundation, International Council for Control of Iodine Deficiency Disorders, Australia
Bull World Health Organ 80:410-3; discussion 413-7. 2002..It is now a multidisciplinary network of 600 professionals in 100 countries...
- Relations between various measures of iodine intake and thyroid volume, thyroid nodularity, and serum thyroglobulinLone B Rasmussen
Institute of Food Research and Nutrition, The Danish Veterinary and Food Administration, Søborg, Denmark
Am J Clin Nutr 76:1069-76. 2002..Iodine intake can be measured in various ways, and each method may have advantages and disadvantages...
- Iodine and/or selenium deficiency alters tissue distribution pattern of other trace elements in ratsBelma Giray
Department of Toxicology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
Biol Trace Elem Res 95:247-58. 2003..The results of this study indicated that iodine and/or selenium deficiency may modify the distribution and the homeostasis of other minerals...
- Assessment of the iodine concentration in table salt at the production stage in South AfricaPieter L Jooste
Nutritional Intervention Research Unit, Medical Research Council, Cape Town, South Africa
Bull World Health Organ 81:517-21. 2003....
- Prevalence and risk factors of iodine deficiency among schoolchildrenEmel Gur
Department of Pediatrics, Cerrahpasa Medical Faculty, Istanbul University, Turkey
J Trop Pediatr 49:168-71. 2003..As there seems to be no effect from the use of iodized salt in iodine deficiency, the use of a more stable potassium iodate for the fortification of salt may be required...
- [Iodine nutritional status and risk factors for iodine deficiency in infants and children of the french North department]G Pouessel
Unité de Gastro Entérologie, Hepatologie et nutrition, Clinique de Pediatrie, Hopital Jeanne de Flandre, 2, Avenue Oscar Lambret, 59037 Lille Cedex, France
Arch Pediatr 10:96-101. 2003..Iodine deficiency is responsible for a higher mortality and morbidity in neonates and infants. It has not yet disappeared in European countries, especially in Southern and Eastern Europe...
- Influence of iodine deficiency and iodine prophylaxis on thyroid cancer histotypes and incidence in endemic goiter areaB Huszno
Department of Endocrinology, Jagiellonian University, Collegium Medicum, Krakow, Poland
J Endocrinol Invest 26:71-6. 2003..The significant difference between IR of thyroid cancer incidence in the districts of Krakow and Nowy Sacz may be related to differences in the exposure to radiation after the Chernobyl accident...
- Improvement of iodine deficiency after iodine supplementation in schoolchildren of Azerbaijan was accompanied by hypo and hyperthyrotropinemia and increased title of thyroid autoantibodiesK B Markou
Department of Medicine, Division of Endocrinology, University of Patras Medical School, University Hospital, Patras, Greece
J Endocrinol Invest 26:43-8. 2003..The aim of the present study was to evaluate the efficacy, the benefits, as well as the possible side-effects in a follow-up period of 6 and 12 months after the initial administration of iodized oil...
- Iodine deficiency disorders in the Saratov province in RussiaM Svinaryov
Department of Endocrinology, Regional Child Hospital, Saratov, Russia
J Endocrinol Invest 26:16-9. 2003..The work deals with epidemiology of iodine deficiency (ID) in the Saratov province in Russia, with clinical data and thyroid autoimmunity disorders in schoolchildren living in a moderate ID area...
- Correction of iodine deficiency in MacedoniaB Karanfilski
Institute of Pathophysiology and Nuclear Medicine, Medical Faculty, St Cyril and Methody University, Skopje, Macedonia
J Pediatr Endocrinol Metab 16:1041-5. 2003..The new regime of salt iodination was proved to be highly effective in correcting the iodine deficiency in Macedonia...
- Bioavailability of iron, zinc, folate, and vitamin C in the IRIS multi-micronutrient supplement: effect of combination with a milk-based cornstarch porridgeFernanda Kamp
Laboratorio de Bioquimica Nutricional e de Alimentos, Instituto de Quimica, Universidade Federal in Rio de Janeiro, Brazil
Food Nutr Bull 24:S20-6. 2003..Therefore, the tested meal is a suitable vehicle for the multi-micronutrient supplement...
- Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter areaKursad Aydin
Department of Pediatrics, Selcuk University Medical Faculty, Konya, Turkey
Biol Trace Elem Res 90:25-30. 2002..These results suggest that IGF-I and IGFBP-3 levels are affected by thyroid dysfunction as a result of iodine and selenium deficiency. However, IGF-I and IGFBP-3 levels are not associated with goiter...
- The evolving applications of spreads as a FOODlet for improving the diets of infants and young childrenAndre Briend
Institut de Recherche pour le Developpement, Institut des Sciences et Techniques de la Nutrition et de l Alimentation, Paris, France
Food Nutr Bull 24:S34-8. 2003....
- [What is possible, now and right]Rodrigo Fierro-Benítez
Rev Panam Salud Publica 12:301-4. 2002
- [Iodine deficiency exists in many European countries but not in Finland]Bror Axel Lamberg
Duodecim 119:1639-42. 2003
- Chernobyl and iodine deficiency in the Russian Federation: an environmental disaster leading to a public health opportunityRichard J Jackson
National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE Mail Stop F 29, Atlanta, Georgia 30341 3717, USA
J Public Health Policy 23:453-70. 2002..The full realization of this goal will require more time for education, marketing, and possibly legislative action...
- [Iodocasein in the prophylaxis of iodine deficiency in servicemen]A L Rakov
Voen Med Zh 324:37-40, 80. 2003..After the initial examination the persons from the main group were given iodized bread during 9 months. The monitoring results have confirmed the efficiency of iodine prophylaxis with the use iodcasein...
- Successful struggle against iodine deficiency disorders (I.D.D.) in CroatiaZ Kusic
Department of Nuclear Medicine and Oncology, University Hospital Sestre Milosrdnice, Zagreb, Croatia
Coll Antropol 21:499-506. 1997..Control of salt produced in Pag revealed the average KI value of 8.3 mg/kg. On the basis of these results Croatian Ministry of Health proclaimed, on October 9, 1996, a new regulation requiring 25 mg KI in each kg of NaCl...
- Thyroid autoantibodies in women with and without thyroid disorders in an iodine-replete areaA Aminorroaya
Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
East Mediterr Health J 14:325-32. 2008..5% of patients with hypothyroidism, 73.6% of those with hyperthyroidism, 48.9% of those with simple goitre and 35.8% of the control group (P < 0.001). Autoimmunity may have a role in the genesis of common thyroid disorders...
- The evaluation of the iodine content of table salt in LesothoMasekonyela L D Sebotsa
Food and Nutrition Coordinating Office, P Bag A78, Maseru, Lesotho
Afr J Health Sci 9:139-45. 2002..81.8% of the households use adequately iodised salt. This however does not meet WHO criteria for elimination of IDD as a public health problem since less than 90% of effectively iodised salt is being used at household level...
- Pilot study: tendency of increasing iodine content in human milk and cow's milkN Bader
Institute of Nutrition, Friedrich Schiller University Jena, Jena, Germany
Exp Clin Endocrinol Diabetes 113:8-12. 2005..There was no difference in the human milk iodine content between mothers taking supplements and those who did not. Cow's milk samples showed a mean iodine concentration of 178 +/- 131 microg/l (range 48 - 661 microg/l)...
- Validation of spot-testing kits to determine iodine content in saltC S Pandav
Clinical Epidemiology Unit CEU, All India Institute of Medical Sciences, New Delhi, India
Bull World Health Organ 78:975-80. 2000..Therefore, we conclude that until a valid alternative is available, the titration method should be used for monitoring the iodine content of salt at all levels, from producer to consumer, to ensure effectiveness of the programme...
- Perspectives from micronutrient malnutrition elimination/eradication programmesB A Underwood
Institute of Medicine, National Academy of Sciences, Washington, DC 20418, USA
Bull World Health Organ 76:34-7. 1998....
- Candidate noninfectious disease conditionsD Alnwick
Health Section, United Nations Children s Fund UNICEF, New York City, New York, USA
Bull World Health Organ 76:55-60. 1998..These same approaches, if successful, could be used to tackle other important micronutrient deficiencies...
- Persistent iodine deficiency in a cohort of Tasmanian school children: associations with socio-economic status, geographical location and dietary factorsKristen L Hynes
Menzies Research Institute, University of Tasmania
Aust N Z J Public Health 28:476-81. 2004..To determine the adequacy of iodine nutrition of Tasmanian primary school-aged children and to examine possible associations with socio-economic status (SES), location and dietary factors...
- Multiple approaches to micronutrient deficiency in developing countriesK Nagati
Tunis Imm Touta Esc Ab Menzah iv, Tunisia
Forum Nutr 56:282-3. 2003
- [Effect of chronic mild and moderate iodine excess on thyroid anti-oxidative ability of iodine deficiency and non-iodine deficiency Wistar rats]Nuo Zhang
Department of Endocrinology, First Affiliated Hospital, China Medical University, Shenyang 110001, China
Zhonghua Yi Xue Za Zhi 86:1274-8. 2006..To investigate the effects of chronic mild and moderate iodine excess on thyroid oxidative injury and anti-oxidative ability of iodine deficiency and non-iodine deficiency Wistar rats...
- Determination of iodine nutrition and community knowledge regarding iodine deficiency disorders in selected tribal blocks of Orissa, IndiaG Bulliyya
Regional Medical Research Centre, Indian Council of Medical Research, Chandrasekharpur, Bhubaneswar, India
J Pediatr Endocrinol Metab 21:79-87. 2008..To determine the status of iodine nutrition and knowledge of iodine deficiency disorders (IDD) in selected tribal mountainous blocks of Orissa, India...
- Micronutrient deficiencies and gender: social and economic costsIan Darnton-Hill
UNICEF Nutrition Section and Institute of Human Nutrition, Columbia
Am J Clin Nutr 81:1198S-1205S. 2005....
- A case for universal salt iodisation to correct iodine deficiency in pregnancy: another salutary lesson from TasmaniaJohn R Burgess
Royal Hobart Hospital, Hobart, TAS
Med J Aust 186:574-6. 2007..To assess the impact of iodine fortification of bread on the iodine status of pregnant women, and to determine if studies of iodine levels in school-age children were indicative of women's gestational iodine status...
- A field survey of iodine supplementation of primary school children and their parents in a rural village in the endemic area of iodine deficiency disorder, northeastern ThailandViroj Wiwanitkit
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn, Bangkok, Thailand
Rural Remote Health 7:599. 2007....
- Iodine deficiency: an important and severe public health problem in Kayseri, Central AnatoliaN Budak
University of Erciyes Rectorate, 38039 Kayseri, Turkey
J Endocrinol Invest 30:920-4. 2007..The local "Iodine Monitoring Committee" developed an action plan including information/education/ communication activities to sustain monitoring so as to increase the inclusion of iodized salt in the region...
- Profile of iodine content of salt and urinary iodine excretion levels in selected districts of Tamil NaduUmesh Kapil
Department of Human Nutrition, All India Institute of Medical Sciences, New Delhi, India
Indian J Pediatr 71:785-7. 2004....
- Supplementation of algae to the diet of pigs: a new possibility to improve the iodine content in the meatM L He
Institute for Physiology, Physiological Chemistry and Animal Nutrition, University of Munich, Munich, Germany
J Anim Physiol Anim Nutr (Berl) 86:97-104. 2002..05). It is suggested that the carry-over of iodine through feeding pigs with an algae-supplemented feed could be beneficial to both the control of IDD and the improvement of pig production...
- Micronutrients in health and diseaseA Shenkin
Division of Clinical Chemistry, University of Liverpool, Liverpool L69 3GA, UK
Postgrad Med J 82:559-67. 2006..More clinical trials are required with good clinical outcomes to optimise intake in prevention and treatment of disease...
- [Assessment of iodine content of dietary salt in Abidjan (Côte d'Ivoire)]Pierre Adou
Laboratoire de Nutrition, Institut National de Santé Publique, BP V 47, Abidjan, Cote d Ivoire
Sante 12:18-21. 2002..From this arises the need for setting up an effective system of controlling the iodine content in dietary salt to continuously adjust it, taking into consideration the minimum needs of the population...
- An assessment of urinary and breast milk iodine concentrations in lactating mothers from Gorgan, Iran, 2003Hamid R Bazrafshan
Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Iran
Thyroid 15:1165-8. 2005..44, p < 0.0001). Iodine deficiency and goiter were associated (p < 0.0001). UIC and MIC concentrations are sufficient in Gorgan, Iran. However, individual infants remain at risk for low iodine intake via breast milk...
- [Iodine deficiency: current situation and future prospects]Bruno de Benoist
Département de nutrition pour la santé et le développement, Organisation mondiale de la Sante, CH 1211 Genève 27, Suisse
Sante 12:9-17. 2002..In order to reach the goal of IDD elimination, it is important to insist on the sustainability of salt iodisation programmes, which implies an increased commitment of both health authorities and representatives of the salt industry...
- Iodine supplementation of pregnant women in Europe: a review and recommendationsM Zimmermann
Laboratory for Human Nutrition, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Ruschlikon, Zurich, Switzerland
Eur J Clin Nutr 58:979-84. 2004..The objective of this review was to examine the iodine status of pregnant women in Europe and the potential need for iodine supplementation...
- Iodine concentration in salt at household and retail shop levels in Shebe town, south west EthiopiaL Takele
South People Nations and Nationalities People s Regional Health Bureau, Jimma, Ethiopia
East Afr Med J 80:532-9. 2003..To determine the level of iodine in the salt at the retail shop and consumption levels and assess the knowledge, attitude and practice (KAP) of food caterers and shopkeepers about iodized salt and iodine deficiency disorders (IDD)...
- [Neonatal thyrotropinemia (TSH) as an indicator of iodine nutritional level in Castellon and Valencia, Spain (2004-2006)]Carmen Barona-Vilar
Servici de Salut Infantil i de la Dona, Direcció General de Salut Pública, Conselleria de Sanitat, Generalitat Valenciana, C Micer Mascó 31, Valencia, Spain
Rev Esp Salud Publica 82:405-13. 2008....
- Functional dichotomy: glutathione and vitamin E in homeostasis relevant to primary open-angle glaucomaJohn Veach
Br J Nutr 91:809-29. 2004..POAG is not believed to be a 'vitamin-deficiency disease'. The concept of 'vitamin-deficiency diseases' and the recommended daily allowances have not kept pace with the growing understanding of the cellular and ..
- Meeting the challenges of micronutrient deficiencies in emergency-affected populationsZ Weise Prinzo
Department of Nutrition for Health and Development, World Health Organization, 1211 Geneva 27, Switzerland
Proc Nutr Soc 61:251-7. 2002Micronutrient deficiencies occur frequently in refugee and displaced populations. These deficiency diseases include, in addition to the most common Fe and vitamin A deficiencies, scurvy (vitamin C deficiency), pellagra (niacin and/or ..
- Definition and measurement of child malnutritionK Y Ge
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China
Biomed Environ Sci 14:283-91. 2001..overnutrition (overweight and obesity) due to excessive consumption of energy and other nutrients; deficiency diseases due to insufficient intake of one or more specific nutrients such as vitamins or minerals...
- [Ocular Manifestation of Mucopolysaccharidosis I-S (Scheie's Syndrome)]Arne Viestenz
Augenklinik mit Poliklinik der Universität Erlangen Nürnberg, Erlangen, Germany
Klin Monbl Augenheilkd 219:745-8. 2002..Bilateral stromal corneal opacifications are a differential diagnostical challenge to identify associated systemic diseases...
- Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivoStephanie C Colvin
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Proc Natl Acad Sci U S A 108:173-8. 2011The etiology of most pediatric hormone deficiency diseases is poorly understood...
- Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs)Musiliyu A Musa
Florida A and M University, College of Arts and Sciences, Department of Chemistry, 219 Jones Halls, Tallahassee, FL 32307, USA
Curr Med Chem 14:1249-61. 2007..Therefore, the therapeutic goal of SERMs is the prevention of estrogen deficiency diseases without promoting estrogen-associated tumor growth...
- Medical geology in tropical countries with special reference to Sri LankaC B Dissanayake
Department of Geology, University of Peradeniya, Peradeniya, 20400, Sri Lanka
Environ Geochem Health 29:155-62. 2007..Iodine deficiency diseases are more common in the Wet Zone, though their aetiologies are more complicated...
- [Sudden infant death syndrome (SIDS) caused by ATP-depletion following hyperventilation, tissue-hypoxia and hypermetabolism--a hypothesis]E Deixler
IV Medizinische Abteilung, Rheumatologie und Klinische Immunologie, Städtisches Klinikum München GmbH, Krankenhaus Munchen Bogenhausen, Akademisches Lehrkrankenhaus der Technischen Universität München
Z Geburtshilfe Neonatol 213:122-34. 2009..Hypoxia plays a major role in the pathogenesis, but the exact mechanism is not fully understood...
- [Iodine levels in food and soil in different regions in Cameroon]Ibrahim Taga
Faculte des Sciences, BP 24157, Université de Douala, Cameroon
Sante 14:11-5. 2004Iodine deficiency diseases (IDD) are a public health problem in many developing countries, such as Cameroon...
- [Syndrome differentiation and treatment of Taiyang disease in Shanghan Lun]Xue Yang
Department of Classics, School of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China
Zhong Xi Yi Jie He Xue Bao 7:171-4. 2009..To explore the laws in syndrome differentiation of Taiyang disease and the prescriptions and herbs used in its treatment in Shanghan Lun (Treatise on Febrile Diseases)...
- Low exchangeability of selenocysteine, the 21st amino acid, in vertebrate proteinsSergi Castellano
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
Mol Biol Evol 26:2031-40. 2009..for the dependence of vertebrates on environmental selenium (Se) and have an important role in several Se-deficiency diseases. Selenoproteins are poorly characterized enzymes and reports on the functional exchangeability of Sec with ..
- Four novel mutations underlying mild or intermediate forms of alpha-L-iduronidase deficiency (MPS IS and MPS IH/S)P T Tieu
Department of Biological Chemistry, UCLA School of Medicine 90024 1737, USA
Hum Mutat 6:55-9. 1995The alpha-L-iduronidase deficiency diseases (Mucopolysaccharidosis I) cover a spectrum of clinical severity ranging from the very severe (Hurler syndrome, MPS IH) through an intermediate (Hurler/Scheie syndrome, MPS IH/S) to a relatively ..
- Time trend investigation of PCBs, PBDEs, and organochlorine pesticides in selected n-3 polyunsaturated fatty acid rich dietary fish oil and vegetable oil supplements; nutritional relevance for human essential n-3 fatty acid requirementsMiriam N Jacobs
School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom
J Agric Food Chem 52:1780-8. 2004..the prevention and treatment of cardiovascular, immunological, and arthritic diseases, as well as childhood deficiency diseases such as rickets, because of a high content of vitamin D...
- Abnormal sterols in cholesterol-deficiency diseases cause secretory granule malformation and decreased membrane curvatureMARJORIE C GONDRE-LEWIS
Section on Cellular Neurobiology, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
J Cell Sci 119:1876-85. 2006....
- Impact of Giardia intestinalis on vitamin a status in schoolchildren from northwest MexicoL Quihui-Cota
Department of Human Nutrition, Centro de Investigacion en Alimentacion y Desarrollo, A C Hermosillo, Sonora, Mexico
Int J Vitam Nutr Res 78:51-6. 2008..program developers and policymakers should be aware about the distinction between dietary deficiencies and deficiency diseases when current national program strategies for parasitic control and vitamin A supplementation are redesigned.
- The diagnostic importance of photosensitivity dermatoses in chronic alcoholism: report of two casesChrisoula Pipili
Department of Internal Medicine, General Hospital of Sitia, GR 72300, Greece
Dermatol Online J 14:15. 2008Many of the vitamin deficiency diseases have been almost completely eliminated in developed countries. Niacin deficiency is considered one of them...
- Selenium in human and animal nutrition: resolved and unresolved issues. A partly historical treatise in commemoration of the fiftieth anniversary of the discovery of the biological essentiality of selenium, dedicated to the memory of Klaus Schwarz (1914-1Gerhard N Schrauzer
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA
Crit Rev Biotechnol 29:2-9. 2009..To prevent selenium-deficiency diseases in livestock, additions of selenium to animal feed are required and were approved for all species, but the ..
- Selenium: its role as antioxidant in human healthUjang Tinggi
Centre for Public Health Sciences, Queensland Health Scientific Services, 39 Kessels Road, Coopers Plains, QLD, 4108, Australia
Environ Health Prev Med 13:102-8. 2008..Concern for potential deficiency diseases associated with low Se status has led to the establishment of the recommended daily requirements for Se in ..
- Artificial cell biotechnology for medical applicationsT M Chang
Artificial Cells and Organs Research Centre, Departments of Physiology, Medicine and Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Blood Purif 18:91-6. 2000..Artificial cells containing enzymes are being developed for clinical trials in hereditary enzyme deficiency diseases and other diseases...
- Artificial cells for replacement of metabolic organ functionsThomas Ming Swi Chang
Artificial Cells and Organs Research Centre, MSSS FRSQ Research Group on Blood Substitutes in Transfusion Medicine, Physiology, Medicine, and Biomedical Engineering, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Artif Cells Blood Substit Immobil Biotechnol 31:151-61. 2003..Artificial cells containing enzymes are being developed for clinical trial in hereditary enzyme deficiency diseases and other diseases...
- Safety and efficacy of self-administered subcutaneous immunoglobulin in patients with primary immunodeficiency diseasesHans D Ochs
Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98107, USA
J Clin Immunol 26:265-73. 2006..at 3-4 week intervals are currently standard therapy in the United States for patients with primary immune deficiency diseases (PIDD)...
- Biofactors in the Mediterranean dietMariette Gerber
Groupe d Epidémiologie métaboliques, Centre de Recherche en Cancerologie, INSERM CRLC, Montpellier, France
Clin Chem Lab Med 41:999-1004. 2003..Vitamins were first identified because of deficiency diseases still present in certain parts of the world...
- Artificial cells for cell and organ replacementsThomas Ming Swi Chang
Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, Montreal, Quebec, Canada
Artif Organs 28:265-70. 2004..Artificial cells containing enzymes are being developed for clinical trial in hereditary enzyme deficiency diseases and other diseases...
- A mathematical model of neonatal tidal liquid ventilation integrating airway mechanics and gas transfer phenomenaChiara Corno
Bioengineering Department, Politecnico di Milano, Milan MI 20133, Italy
IEEE Trans Biomed Eng 51:604-11. 2004..TLV) was proposed as an alternative to conventional mechanical ventilation in the case of surfactant-deficiency diseases, particularly for very premature subjects...
- Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cellsYanwen Peng
Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, PR China
Cell Biol Int 32:1265-71. 2008..polypeptides have been widely used clinically for the treatment of tumors, infectious diseases and immune deficiency diseases. They have already shown the ability to stimulate the maturation of hematopoietic stem cells towards the ..
- Recommendations for accelerating global action to prevent folic acid-preventable birth defects and other folate-deficiency diseases: meeting of experts on preventing folic acid-preventable neural tube defectsGodfrey P Oakley
Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Birth Defects Res A Clin Mol Teratol 70:835-7. 2004..effective and sustainable programs to prevent folic acid-preventable birth defects and other folate-deficiency diseases. Programs implemented to date by fewer than 40 countries have prevented only 10% of the estimated 240,000 ..
- Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagementJ B Petro
Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
J Exp Med 191:1745-54. 2000Mutations in the gene encoding Bruton's tyrosine kinase (btk) cause the B cell deficiency diseases X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice...
- Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and managementLinda M Griffith
Division of Allergy, Immunology and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
J Allergy Clin Immunol 124:1152-60.e12. 2009..Finally, we discuss the role of high-quality databases in treatment of PIDs and HCT as an element of the infrastructure that will be needed for productive multicenter clinical trials in these rare diseases...
- From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good healthAnthony W Norman
Department of Biochemistry and Division of Biomedical Sciences, University of California, Riverside, CA, USA
Am J Clin Nutr 88:491S-499S. 2008..However, worldwide reports have highlighted a variety of vitamin D insufficiency and deficiency diseases. Despite many publications and scientific meetings reporting advances in vitamin D science, a disturbing ..
- Metabolic changes in malnutritionP W Emery
Department of Nutrition and Dietetics, King s College London, London, UK
Eye (Lond) 19:1029-34. 2005This paper is concerned with malnutrition caused by inadequate intake of all the major nutrients rather than deficiency diseases relating to a single micronutrient...
- Toward a new definition of essential nutrients: is it now time for a third 'vitamin' paradigm?J J Challem
Aloha, Oregon 97006, USA
Med Hypotheses 52:417-22. 1999....
- Two promoters mediate transcription from the human LHX3 gene: involvement of nuclear factor I and specificity protein 1Benjamin C Yaden
Department of Biology B C Y, M G, Indiana University Purdue University Indianapolis, Indianapolis, Indiana 46202, USA
Endocrinology 147:324-37. 2006..Mutations in the human gene are associated with hormone-deficiency diseases. The gene generates two mRNAs, hLHX3a and hLHX3b, which encode three proteins with different properties...
- The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and functionEwald Hannappel
Institute for Biochemistry Faculty of Medicine, University of Erlangen Nurnberg, 91054 Erlangen, Germany
Vitam Horm 66:257-96. 2003..thymic functions in thymic-deprived or immunodeprived animals, as well as in humans with primary immuno-deficiency diseases and in immunosuppressed patients, a standardized extract from bovine thymus gland called thymosin fraction ..
- LHX3 and LHX4 transcription factors in pituitary development and diseaseStephanie C Colvin
Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202 5120, USA
Pediatr Endocrinol Rev 6:283-90. 2009..identified a variety of mutations in the LHX3 and LHX4 genes in patients with combined pituitary hormone deficiency diseases. These patients have complex and variable syndromes involving short stature, metabolic disorders, ..
- The Werner syndrome gene: the molecular basis of RecQ helicase-deficiency diseasesJ C Shen
Department of Pathology, University of Washington, Seattle, Washington 98195 7705, USA
Trends Genet 16:213-20. 2000..Preliminary results indicate that WRN functions as a key factor in resolving aberrant DNA structures that arise from DNA metabolic processes such as replication, recombination and/or repair, to preserve the genetic integrity in cells...
- X-linked agammaglobulinemia in a 10-year-old child: a case studyLissette Estrella
Division of Clinical Immunology, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
J Am Acad Nurse Pract 19:205-11. 2007..To discuss the advanced practice nurse's diagnosis and management of an unsuspected primary immunodeficiency (PI) disease, X-linked agammaglobulinemia (XLA), in a child...
- China: the soyabean-pork dilemmaC Geissler
Department of Nutrition and Dietetics, King s College London, UK
Proc Nutr Soc 58:345-53. 1999..of a nutrition transition in which diseases associated with affluence are becoming more prevalent than deficiency diseases. This transition has led to concern about the evolving dietary pattern...
- Application of agricultural biotechnology to improve food nutrition and healthcare productsSamuel S M Sun
The Chinese University of Hong Kong, Department of Biology, G88 Science Centre South Block, Shatin, NT, Hong Kong, China
Asia Pac J Clin Nutr 17:87-90. 2008..food crop as source of nutrients thus will not achieve a balanced diet and results in malnutrition and deficiency diseases, especially in the developing countries, due mainly to poverty...
- Oral manifestations of primary immune deficiencies in childrenAleksandra Szczawinska-Poplonyk
Department of Pediatric Pneumonology, Allergology and Clinical Immunology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:e9-20. 2009..In this article, symptomatology of selected primary immune deficiency diseases are discussed with particular emphasis on oral manifestations reported in this group of disorders...
- The silkworm mutant lemon (lemon lethal) is a potential insect model for human sepiapterin reductase deficiencyYan Meng
Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
J Biol Chem 284:11698-705. 2009..yellow body coloration, of the silkworm Bombyx mori could be used as the first insect model for human SPR deficiency diseases. We demonstrated that mutations in the SPR gene (BmSpr) were responsible for the irregular body coloration ..
Research Grants62
- ANALYSIS AND MODULATION OF IMMUNITY IN GENE THERAPYPaula Clemens; Fiscal Year: 2003..DESCRIPTION (Abstract): Therapeutic gene transfer is a logical approach to the treatment of inherited genetic deficiency diseases, many of which have no other adequate treatment...
- Cellular &Molecular Defects in Human B Cell DevelopmentCharlotte Cunningham-Rundles; Fiscal Year: 2013DESCRIPTION (provided by applicant): Primary immune deficiency diseases provide an unparalleled resource for investigators in human immunology...
- Role of LHX3 Protein Isoforms in Pituitary DevelopmentSIMON JAMES RHODES; Fiscal Year: 2012..and others have recently described that mutations in the LHX3 gene cause combined pituitary hormone deficiency diseases, and other symptoms such as nervous system problems, in children...
- Bone Marrow Transplant Clinical NetworkEdward A Stadtmauer; Fiscal Year: 2010..hematopoietic stem cell transplantations (HCT) were done in 1968 in three children with congenital immune deficiency diseases. In each instance, stem cells were collected from the bone marrow of sibling donors who were genotypically ..
- Resources to Assist Investigations in Primary Immunodeficiency Diseases (U24)Charlotte Cunningham-Rundles; Fiscal Year: 2013DESCRIPTION (provided by applicant): Primary Immune Deficiency Diseases (PIDDs) include a group of rare diseases whose clinical manifestations encompass multiple clinical specialties...
- In-vivo miRNA Detection Using Structurally Interacting RNA (sxRNA)Scott A Tenenbaum; Fiscal Year: 2011..sxRNA could be an RNA-based alternative to gene therapy for protein deficiency diseases, such as cystic fibrosis, or a cancer therapy...
- LINGUAL SEROUS GLANDS--REGULATION OF ENZYME SECRETIONRUTH FIELD; Fiscal Year: 1992..When the complete mechanism of secretion is known, it will be possible to use this knowledge to treat pancreatic deficiency diseases by stimulating secretion of lingual lipase.
- BONE MARROW TRANSPLANTATION FOR MUCOPOLYSACCHARIDOSISChester Whitley; Fiscal Year: 1993..of introducing large amounts of enzyme-producing cells on a continuous basis into patients with enzyme deficiency diseases; (2) long-term engraftment by normal donor cells results in metabolic correction as demonstrated by ..
- 2nd North American meeting by CIS devoted to primary immune deficiency.Charlotte Cunningham-Rundles; Fiscal Year: 2012..The 2012 CIS Annual Meeting: Primary Immune Deficiency Diseases North American Conference, to be held May 17-20, 2012 in Chicago, represents a major new educational ..
- BIOCHEMICAL BASIS OF SULFATASE ACTIVITYALLEN HORWITZ; Fiscal Year: 1992..The understanding of all these processes will be important in devising strategies for the treatment of enzyme deficiency diseases.
- OVARIAN TOXICITY OF GALACTOSEClaude Hughes; Fiscal Year: 1999..calcium intake for osteoporosis prevention may actually exacerbate osteoporosis, and other serious estrogen deficiency diseases if their diet concurrently advances ovarian failure or inhibits normal ovarian function prior to ultimate ..
- HISTORY AND CULTURE OF FOOD AND NUTRITIONKENNETH KIPLE; Fiscal Year: 1999..But it is also the case that many of the complexities of nutrition, nutritional chemistry, and deficiency diseases can be daunting for the nonspecialist. The proposed project should remedy this...
- ALPHA-GALACTOSIDASES A, B--MOLECULAR/CELLULAR MECHANISMROBERT DESNICK; Fiscal Year: 1999..alpha-Gal B) by characterization of their respective structural domains, enzyme complexes, and deficiency diseases. To facilitate these studies, we 1) isolated and characterized the full-length human and murine cDNAs and ..
- Prolong the Survival of NSCL Patients by a PhytomixHenry Sacks; Fiscal Year: 2006..non-toxic anticancer and immune-enhancing dietary supplements for the treatment of cancer and immune-deficiency diseases. The specific objective is to test whether a specific mixture of "Selected Vegetables and Herbs Mix (SV)", ..
- TOLERANCE IN PRIMATES--THYMIC IMPLANTATION OF STEM CELLMargaret Allen; Fiscal Year: 2002..Depending on the level of chimerism achieved, the potential for introducing allogenic stem cells into an infant without immunosuppression might also have implications for the treatment of genetic deficiency diseases.
- Regulation of Cardiac Carnitine Palmitoyltransferase IGebre Woldegiorgis; Fiscal Year: 2004..The M-CPTI null mice will allow us to construct models that mimic human CPT deficiency diseases and to look for potential gene therapy through retro-transfection of the normal CPT gene.
- ANTIGEN RECEPTOR GENES FROM TH AND TS CELLSEllen Kraig; Fiscal Year: 1991..A better understanding of the molecular controls operating in immune regulation is of primary importance in determining the basic mechanisms and defects in certain immune deficiency diseases and autoimmune disorders.
- Biochemical basis of WRN and RecQ helicase functionDAVID ORREN; Fiscal Year: 2007..Not surprisingly, the human hereditary RecQ deficiency diseases (Werner, Bloom, and Rothmund-Thomson syndromes, caused by defects in WRN, BLM, and RECQL4, respectively) ..
- LINEAGE COMMITMENT OF T-LYMPHOCYTES DURING DEVELOPMENTRobert Arceci; Fiscal Year: 1991..of such processes are furthermore central to any fundamental understanding of a variety of inherited immune deficiency diseases as well as how immune reconstitution occurs following bone marrow transplantation...
- Bi-Annual Meeting of the IUIS Expert Committee on Primary ImmunodeficiencyRaif Geha; Fiscal Year: 2009Primary immune deficiency diseases (PID) provide an excellent window into the functioning of the immune system. During the past 15 years the molecular basis of more than 100 PID has been elucidated...
- Characterization of Corneal Epithelial Stem CellsMary Ann Stepp; Fiscal Year: 2005..Discovering specific molecular markers for the limbal stem cells will aid in the development of treatments for stem cell deficiency diseases of the ocular surface in humans.
- Structural biology of kinase signaling in T-cellsMichael J Eck; Fiscal Year: 2010..Also, they will help us to understand the causes of immune deficiency diseases XLP and SCID at a detailed molecular level.
- Transcription Regulation by B-Cell Receptor SignalingWasif Khan; Fiscal Year: 2004..Identification of these important missing links may reveal new immunotherapeutic targets for intervention in B-cell deficiency diseases such as XLA.
- Bone-Sparing by Ca Salts With & Without Extra PhosphorusRobert Heaney; Fiscal Year: 2008..1 Description, ..
- BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESSRobert Heaney; Fiscal Year: 2001....
- Mitochondrial Nutrients Protect RPE from Oxidant DamageBruce Ames; Fiscal Year: 2006..This in vitro analysis of mitochondrial nutrients may provide the basis for the development of therapeutic agents that can prevent and/or reduce the retinal and RPE pathophysiology observed in AMD. [unreadable] [unreadable] [unreadable]..
- Nutritional Control of Transcription Factor ExpressionMichael S Kilberg; Fiscal Year: 2010..Our long-term goal is to understand how mammalian cells respond to their nutritional environment through gene expression, using amino acid availability as the model. ..
- ALCOHOL, ACETAMINOPHEN, AND LIVER SINUSOID DYSFUNCTIONROBERT MC CUSKEY; Fiscal Year: 2004..A better knowledge of the hepatic pathophysiology of alcohol bringing also should result. ..
- NUTRITIONAL CONTROL OF ASPARAGINE SYNTHETASEMichael S Kilberg; Fiscal Year: 2010..abstract_text> ..
- Contemporary Diagnosis and Treatment of Vitamin D-Related DisordersMarc Drezner; Fiscal Year: 2006..unreadable] [unreadable]..
- Cardiovascular Consequences of Thyroid DysfunctionElizabeth Pearce; Fiscal Year: 2007..Pearce's career as an independent academic clinical investigator with a focus on thyroid disease and epidemiology. ..
- Increasing Screening Colonoscopy Among Minority WomenMoshe Shike; Fiscal Year: 2004..Demonstration of the feasibility of this model can form the basis for a nationwide project using mammography centers to enhance CRCS. ..
- Benefits & Risks of Popular Weight Loss DietsChristopher Gardner; Fiscal Year: 2003..The data generated from this preliminary/feasibility study will be used to strengthen the proposal and design of a future full-scale study. ..
- DO HIGH DOSE B VITAMINS DELAY AGE-RELATED DECAYBruce Ames; Fiscal Year: 2005....
- Diet Therapy of Long-Chain Fatty Acid Oxidation DefectsMELANIE GILLINGHAM; Fiscal Year: 2005..abstract_text> ..
- Impact of Nutritional Status on Immune Function & HealthPamela Fraker; Fiscal Year: 2003..abstract_text> ..
- S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver DiseaseCraig J McClain; Fiscal Year: 2010..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
- Comparing Effects of 3 Sources of Garlic on Serum LipidsChristopher Gardner; Fiscal Year: 2005..The comprehensive approach taken in this study will provide important evidence for both the public and for health professionals as to whether fresh garlic or garlic supplements have beneficial effects on serum lipids. ..
- IRON DEFICIENCY AND DOPAMINEJohn Beard; Fiscal Year: 2004..This expansion of study to other neurotransmitters will significantly contribute to our knowledge of the effects of iron deficiency on brain functioning in early life. ..
- DIETARY FATTY CONTROL OF INFLAMMATIONKevin High; Fiscal Year: 2002..Health relateness: Answering these fundamental questions will shed critical light on the feasibility of utilizing dietary fatty acids to regulate AA metabolism and related clinical disorders. ..
- Androgen deficiency and Osteopenia in Anorexia NervosaKaren Miller; Fiscal Year: 2002..In the third phase of the study, we will examine the effects of administering testosterone on bone density and body mass. ..
- A.S.P.E.N. Research Workshop on Functional FoodsCraig McClain; Fiscal Year: 2002..abstract_text> ..
- MALDI-TOF MASS SPECTROMETERBruce Ames; Fiscal Year: 2002..abstract_text> ..
- ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINSRobert Cousins; Fiscal Year: 2009..Extensive use will be made of transporter localization using immunohistochemistry and immunocytochemistry and zinc fluorophores as visualized by fluorescence microscopy. ..
- DELAYING MITOCHONDRIAL DECAY WITH CARNITINE AND LIPOATEBruce Ames; Fiscal Year: 2001..abstract_text> ..
- Mechanisms of S-adenosylmethionine in NASHCraig McClain; Fiscal Year: 2009..Determine by proteomic analysis of serum and liver biopsies the proteins (esp. oxidative stress, oxidized and mitochondrial proteins) that may play a role in the diagnosis or etiology of NASH, and which may be modified by SAMe therapy ..
- FUNCTIONAL SIGNIFICANCE OF EARLY IRON DEFICIENCYBetsy Lozoff; Fiscal Year: 2008..abstract_text> ..
- Phospholipid and Arachidonic Acid Signaling in EpilepsyNicolas Bazan; Fiscal Year: 2007..abstract_text> ..
- Nutritional Regulation of Ribosomal Protein ExpressionMichael Kilberg; Fiscal Year: 2005..The proposed experiments test important hypotheses and will generate valuable new information regarding the mechanisms by which mammalian cells respond to changes in amino acid availability. ..
- Tuning-Up Human MetabolismBruce Ames; Fiscal Year: 2005..Previous results showed that high doses of key mitochondrial metabolites delay mitochondrial decay and involve Km. 4) Minimizing DNA damage and cancer by optimizing micronutrient levels, particularly in the elderly. ..
- Brucella, Aging and Role of IL-17 in Host DefenseKevin High; Fiscal Year: 2005..The data generated in this proposal will form the foundation of future R01 proposals aimed at enhancing immunity vs. intracellular pathogens in our aging population. ..
- Regulation of Arginase Genes in Sepsis and TraumaSidney Morris; Fiscal Year: 2005..abstract_text> ..
- Effect of Selenoprotein SNPs on Prostate Cancer RiskMargaret Rayman; Fiscal Year: 2005..Reduction of cancer incidence in these sub-groups would reduce the incidence of prostate cancer in the population. ..
- ANDROGEN PRODUCTION IN ADRENARCHE AND PCOSWALTER MILLER; Fiscal Year: 2006..abstract_text> ..
- QUANTITATIVE METALLOPROTEOMICS: THE HUMAN ERYTHROCYTEBruce Ames; Fiscal Year: 2006..abstract_text> ..
- Mitochondrial Metabiolites to Treat Parkinson's DiseaseBruce Ames; Fiscal Year: 2005..This project on PD is a new direction for our work on preventing mitochondrial decay and could lead to an effective and cost efficient prevention /therapy for PD. ..
- Genetics of Congenital Left-sided Heart DefectsKim McBride; Fiscal Year: 2007..The proposed studies will launch the applicant on an independent research career, providing a base on which to advance genetic analyses of CCVM with the aim to reduce their occurrence and provide new treatment opportunities. ..
- Effect of Antioxidants on Inflammatory Markers and FMVDChristopher Gardner; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Arginine and Ovine Model for Fetal Growth RestrictionGuoyao Wu; Fiscal Year: 2007..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. [unreadable] [unreadable] [unreadable]..
- THE PATHOGENESIS OF AUTOIMMUNITY IN A MURINE MODEL OF PRIMARY BILIARY CIRRHOSISMERRILL E GERSHWIN; Fiscal Year: 2010..abstract_text> ..


text:
Ship of Fools: How Stupidity and Corruption Sank the Celtic Tiger
A fascinating and deeply shocking account of the recent financial collapse of Ireland's economy. Writing in stridently polemical tones, prominent Irish journalist O'Toole (White Savage ) blends strong reportage with perceptive cultural analysis to produce a disturbing account of how politicians, property developers, and business elite, through a mixture of corruption, feckless deregulation, and plain incompetence, reaped enormous financial gain at a cost of billions to the Irish taxpayer. Tracing Ireland's indulgent attitude toward political corruption and sleaze from the 1970s to the present, the author outlines various financial scandals, including institutionalized tax evasion and the role of unscrupulous and unethical businessmen in the creation of an unsustainable property bubble, the bursting of which has inflicted serious damage on the economy. Occasionally, the author's rhetorical excesses irritate, and the book's focus on analysis rather than any chronological development of events may leave some readers confused. The book's conclusions are highly provocative, however, such as the remarkable suggestion that Catholic Ireland's obsession with the body as the locus of sin hindered the development of any genuine sense of social morality. An absorbing indictment of unregulated, free-market capitalism. (Mar.)
Release date: 03/01/2010

subset: commoncrawl


text:
So I haven't written in here in a while. The last time I wrote in here I was training for my first marathon. Well I ran my first marathon in December and it was awesome. I finished in 4:46, not fast but I just wanted to finish. The training and the run itself left me pretty beat up and since then I have completely changed how I train and run for the better. I have adopted the Crossfit Endurance model and it has been working great so far. So great in fact that I'm training for my first ultra now. I'm going to be running the Mt. Diablo 50k on June 2. So I'm in my last 2 weeks of build before I go into a taper. I'm going to be running 22 or 23 miles this weekend and 25-26 miles next weekend then taper. I'm really excited and looking forward to running my first ultra, and just to make it a little more special it also happens to be on my 29th birthday right next to my home town. Boom Pretty awesome. So I guess I'll try and write on here a little more.
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Comments (4)
thanks everyone. I'm excited to run my first ultra. If this goes well I've got my eye on a 50 miler later in the year too.
Good luck with the last bit of training and with the ultra!
Crazy cool!
Keep running and writing!
Keep running and writing!
Yes, keep writing!!! Congrats on signing up for your first ultra!!! HOW exciting!!!! We expect a full report!


text:
Photos are for members only!!
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Escort ads, casual sex groups, personal ads, video chat and much more.
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text:
Doing the Right Thing
All of us solo and small firm lawyers have experience with those "dog" cases that drive us crazy and often lose us money in the process. This article, Spotting the Losers, James McElhaney (ABA Journal June 2005) offers some ways to clear the duds off your desk – or pass off cases that may not be valuable to you to another firm that could profit from them. But what I liked best about this article, was the conclusion. Because even though so many of us have lost money off cases or been burned by difficult clients, the author eloquently reminds us that sometimes, we take a loser case because it's the right thing to do:
Finally, don't carry any of these ideas to excess. There are some law firms that have the reputation of taking only 'perfect' cases with wonderful clients who never act difficult and who always make a good impression with the judge and jury. Some of these firms never take on a hard case or represent an annoying client for any reason. They are lawyers who never know the satisfaction of having made a contribution to the development of the law, or never feel the pride of having given some of their time to make the world a little more fair.
Not every deserving case is a popular cause or earns a big fee," said Angus. "There are times when you need to take the albatross that walks in your office just because it's the right thing to do."


text:
Ask Prices, Offers, and Time to Sale in an Online Exchange
By examining an online computer exchange, we find that sellers who place higher nonbinding ask prices have higher outstanding offers and remain on the exchange longer, suggesting a willingness to hold out for higher offers. Additionally, higher ask prices deter buyers from making offers. The results are stronger in thinner market segments, suggesting that gains from waiting for a high price are greater when buyers' tastes are idiosyncratic. These relationships are consistent with models in which buyers engage in costly search and suggest that online exchanges may not eliminate the frictions related to bilateral transactions. (JEL D8, L0, L1) Copyright 2004, Oxford University Press.
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Volume (Year): 42 (2004)
Issue (Month): 1 (January)
Pages: 14-28
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text: 2/17/14 2/09/14 POPSUGAR Fashion Lela Rose Lela Rose Fall 2014 Runway Show | New York Fashion Week A Ladylike Flock of Fabulous Dresses From Lela Rose February 9, 2014 by Justin Fenner 40 Shares Chat with us on Facebook Messenger. Learn what's trending across POPSUGAR. View On One Page Photo 43 of 45 ADVERTISEMENT () Start Slideshow Share This Link Copy What's Your Reaction? Thanks for your reaction Don't forget to share this with your friends! ← Use Arrows Keys → 43 Lela Rose Fall 2014 0 previous images 14 more images Previous Next Start Slideshow Fall 2014CollectionsLela RoseRunwayNew York Fashion WeekFashion Week


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Duchess Kate Wears Matthew Williamson To 'African Cats' Premiere [PHOTOS]
Making their first appearance together since William returned from training in The Falklands, The Duke and Duchess of Cambridge attended tonight's UK premiere of African Cats in aid of Tusk at The BFI Southbank in London. The foundation, of which William has been a patron since 2005, was established to protect wildlife in Africa.
The Disney documentary, according to Grazia, tells the story of a family cheetahs and a pride of lions. William is due to give a speech prior to the screening, which will be attended by about 100 children.
This is the first of three royal engagements Will and Kate will appear at prior to their one-year wedding anniversary on Sunday. Tomorrow they will stop by Goldsmith's Hall, and then make an appearance at the Imperial War Museum. Our friend, Victoria Arbiter told us that the couple will most likely spend their anniversary on Sunday holed up together in Anglesey.
Catherine wore a two-piece dove grey number with embellishments from Matthew Williamson's pre-fall 2012 collection (thanks to WhatKateWore for that speedy discovery). HRH left her gorgeous jewels at home so that the pops of color could get top billing. Her hair, done by The Richard Ward Salon, was perfect and bouncy. William, ever the gentleman, held an umbrella to keep his wife's locks dry.
Susan from What Kate Wore believes that Catherine's outfit was customized by Williamson. When the Daily Express's Richard Palmer asked if the design had been altered in any way, Susan tweeted, "The basic frock is from his pre-fall 2012 collection. He added jewels/beading at collar to match cuffs & v-drop on front."
According to the Daily Mail, The Tusk Trust co-founder Charlie Mayhew spoke about how essential the heir's support is. "It's enormously important and enormously valuable to have as our royal patron Prince William. His role, despite the Tusk agenda, on the global stage (is important) not just for our work but communicating the conservation message that everybody in conservation wants to get across. He's a powerful advocate for conservation in general.
Mayhew added, "Kate as we know got engaged to Prince William out in Africa and she's got the same general love of the continent as he has. She very kindly came to LA (with William) to launch our USA patrons circle. I cannot tell you how successful that was."


text: It's a handmade montage: cake toppers, paper flowers, and petal cones… pants optional #Wedding Porn#DIY#paper flowers#red dress#video games April 30 | Catherine Clark bijouxandbits Jill and Dustin's best men… sans pants. Photo by JillyKay Photography When you start a week on a beach with no pants, you know it's going to be a good week. Sadly, we're all probably at work, pants probably mandatory. But to make up for it, I'm showing you some of my favorite reader submissions from the Tribe, the Flickr Pool, and Pinterest. This week I went a little overboard with the handmade items, but can there ever be too much? There are Legend of Zelda cake toppers, DIYed paper flowers, sweet little petal cones, and even a Han Solo in carbonite candy mold. Tribesmaid Deweyandchaucer's handmade groom's cake toppers from GeekMythologyCrafts on Etsy gets major geek cred. Tribesmaid Creepingminx had some crazy beautiful paper flower bouquets at her wedding. Source: julietinton.squarespace.com via Ariel on Pinterest Tribesmaid Baconkins crafted these Scott Pilgrim comic flowers based on this tutorial. Tribesmaid Befuddledlife has me mesmerized by the flowers, the red hair, the red dress, and amazing makeup. Photo by Shaun McCoy Green and purple petal cones made by Rachel. Related Post A red and black self-catered wedding with group dances and a bounce house Michelle and Jose fused black, red, and a playful sense of fun for their wedding at California's The Secret Garden Lindsay. The pair brought a... Read more Best dance shot or bestest dance shot from BajosMom and her groom? This is Patches, the very well-loved stuffed turtle who acted as ring bearer at Keri and Jeff's wedding. Photo by Derek Warnecke This handmade vintage-style hat fits right in with this week's era-inspired theme! Source: etsy.com on Pinterest After featuring a Millennium Falcon candy mold in this montage, I knew this Han Solo mold would be a great pairing! Source: amazon.com on Pinterest Click these fabulous Clicky Links: What we've pinned this week: DIY ruched fabric runners and some corset-laced tights. This is a super sweet balloon-filled proposal. (The bride enters at 5:26) ᔥ Shutter Life Productions and the groom, Patrick. I really wish I had found this last week during our bookish theme week, but better late than never. These "book fair" kits from Scathingly Brilliant would make awesome favors or wedding party gifts! Offbeat Home talked about how personality type affects getting your house work done, but I think it totally applies to getting your wedding planning tasks done too! Offbeat Mama posted an awesome paper making tutorial and a heart-wrenching story of a wife leaving her family. Talk about diverse topics! Find us on Twitter, Facebook, Pinterest, and Flickr! Psst… what are those weird squigglies after the links, anyway? Hey, photographers! I love you and do my best to attribute all Monday Montage photos, but sometimes brides don't include your info when they submit photos. If I've featured your work but it isn't properly credited, email me! Get your daily dose of Offbeat AWESOME Reporter Name * Reporter Email * Original text Enter the original text here. Edited text* Enter your suggested copyedit here. Notes You can add a note for the editor here. * Required information. Fix Typo Catherine Clark Catherine Clark is Offbeat Bride's Senior Editor. In her spare time she loiters at her local library, makes art, watches movies en masse, plays video and tabletop games, poorly cooks healthy things, cuddles with her feline fur baby, and blogs at BijouxandBits.com. @enidjcoleslaw @bijouxandbits @bijouxandbits PREVIOUS Shannon & Fran's 1920s era vegan-friendly potluck wedding NEXT How I figured out what to wear despite my gender ambivalence Show/Hide comments [ 9 ] Han Solo in carbonite candy molds now in registry! 😀 1 agrees Reply I'm loving the pants optional pic! My fiance and his boys would so do that. I can see it now. Sadly…I don't think my eyes would recover! 1 agrees Reply Holy crap. I need to know where that outfit the man in the photo of the dancing couple got his duds. Need! 1 agrees Reply He got his whole outfit (including the top hat he wore for the ceremony) at http://www.gentlemansemporium.com I actually found them because another bride had posted it on this site! Reply Haha, right after I posted that my friend linked me right to it out of the blue! Now if I can just convince the intended that he needs to wear something similar. Reply hahaha!pants aside, i love the flying tie in the first pic! HAHAHAHA!!!! <3 Reply Love the much-loved ring-bearer – and the confidence of the bride/groom who could carry it off 1 agrees Reply I love that turtle so much. And so does someone else, clearly. 🙂 Reply Adding to the turtle love! Hmmm…My intended has a collection of adorable stuffed moose…surely one of them should be a ring bearer – two rings, two antlers; it all makes sense. Now to convince HIM! 🙂 Reply Join the conversation Cancel Reply Your email address will not be published. Required fields are marked *Comment Participate in this conversation via emailGet only replies to your comment, the best of the rest, as well as a daily recap of all comments on this post. No more than a few emails daily, which you can reply to/unsubscribe from directly from your inbox. No-drama comment policy Part of what makes the Offbeat Empire different is our commitment to civil, constructive commenting. Make sure you're familiar with our no-drama comment policy. Biz owners & wedding bloggers Please just use your real name in your comment, not your business name or blog title. Our comments are not the place to pimp your website. If you want to promote your stuff on Offbeat Bride, join us as an advertiser instead.


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Originally published on December 7, 2015 4:15 pm
There's no denying certain songs are best experienced when played as loud as possible. Since this Friday, 11/11/11, is Nigel Tufnel Day — the unofficial holiday honoring the fictional Spinal Tap guitarist, who cranked his amplifiers past 10 — this week's episode is all about the songs that instantly make you want to turn the volume up.
Such songs can be simple and anthemic, like The Modern Lovers' garage-punk or Kelly Clarkson's roller-coaster pop. Or they can be densely layered, like LCD Soundsystem's studio wizardry or OutKast's all-out aural assaults. But in each case, the message is the same: Let the music, whatever it might be, overwhelm you.
What songs do you prefer to hear as loud as possible? Leave your suggestions here.
Copyright 2015 NPR. To see more, visit http://www.npr.org/.


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NetWellness is a global, community service providing quality, unbiased health information from our partner university faculty. NetWellness is commercial-free and does not accept advertising.
Wednesday, September 20, 2017
Ischemic attack
Is a hypoxic ischemic encephalapathy insult to the brain the same as a stroke? Does a stroke always show up on a MRI? Does it take time for it to show up?
In a sense, yes. Hypoxic ischemic encephalopathy means that the patient has diminished cognitive function due to brain injury that is caused by a lack of blood flow. The most common cause for this is low blood pressure or complete lack of blood pressure as in a cardiac arrest. Brain injury is usually on both sides of the brain, and can be quite severe.
This is a little different from a typical stroke, which generally only involves blockage of one blood vessel, and thus involves only damage to the part of the brain fed by the blocked artery.
Both are similar in that brain cells die due to lack of oxygen and nutrients.
Stroke almost always shows up on a MRI scan. It can take time for it to show up, but we would expect to see the stroke within a day or two after symptoms begin at latest. Some MRI techniques can be used to image a stroke within 30 minutes of onset.
I hope this has answered your questions. If not, please feel free to write back.
Brett Kissela, MD
Assistant Professor of Neurology
Director, Neurology Residency Program
College of Medicine
University of Cincinnati


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Full-figured women rely on Knee Ripped Black Jeans jeans as an essential part of their casual attire. There are many varieties and colors of jeans that are available for this group. If you are a plus size lady you can find jeans that are made for your specific body type whether you are tall or short, pear-shaped or well-rounded. There is a jean available that will emphasize your best attributes and camouflage your flaws. The right fitting jean is a great addition to any wardrobe.
It is important to accept the shape and size of your body, and get over the fact that you are not a size 6 or 8, before you go shopping for a pair of jeans. When you do not accept yourself, they are negative thoughts, and they will make you have a negative image about yourself. Focus on the fact that you are a healthy woman. This will make it easier to find a pair of jeans that is so you!
It depends upon the manufacturer, of course, but larger size jeans usually come in sizes 14 to 28. Size 14 in a plus size garment generally corresponds to a 16 regular. Larger size dungarees are offered with "Misses" measurements and with "Junior" measurements. The former term means that the legs are looser, the hip section is wider, and the waistband sits higher than it does in the Juniors.
Jeans in a "junior" cut fit snugly in the leg and sit low on the waist. They are rather form-fitting, and full-figured shoppers should try on both jean cuts, taking into consideration their comfort and style, as well as the look. Model the different cuts in a full-length mirror, or, better yet, a three-way mirror, so that you can evaluate the fit from a number of perspectives. Make sure you are completely satisfied in every way before you buy. There is no best cut-it is a personal choice.
Full figured women who have a "pear" shape prefer boot cut jeans. A pear shaped body can be described as being biggest in the middle section (from the lower part of the stomach to the upper thighs).
Boot cut jeans are popular because they de-emphasize the longer part of the body, which is a slimming look. Boot cut jeans generally look better with shoes with a heel or even platform shoes instead of shoes with a flat heel.
Tapered jeans usually do not look good on a plus size woman and should be avoided, unless you really want to draw attention to the least liked parts of your body. Tapered style bottoms should really be reserved for the very thin girls.
If you are of a larger size than average, you have already realized that occasionally, the pickings for clothing that is flattering as well as comfortable is often quite scarce. Sometimes, it feels that the only options available are baggy, unattractive and overly expensive to boot! Luckily enough, times are changing and everyone from top-shelf designers to more everyday marketers are realizing that not only do larger women want fun and exciting clothing options, but that they are willing to pay for them too! At this point in time, we are experiencing a renaissance in clothing, and it is no longer difficult or frustrating to find clothing that suits you well.
While shops like Lane Bryant and Torrid have been around for quite sometime, they are still some of the leading voices when it comes plus-sized fashion. If you look closely at the designs available from places like this, you'll note some interesting things about them. The first thing that you'll see is the fact that these clothes are not simply the smaller sizes scaled up. This is actually very important, something that some other designers haven't caught on to yet. You'll find that when you buy clothes specifically tailored to your size, you'll discover that they are actually readjusted for the needs of your own body.
For instance, while some women carry their weight evenly distributed through their bodies, other women will carry their weight primarily in their hips. As can easily be seen just from a written description, two women with two different body types would certainly have different needs when it came to clothing. It is becoming easier to find designers who are interested in reflecting the wide variety in women that they service and providing clothes that fit well and flatter rather than make obvious attempts at concealment.
One thing that many people do not realize is that women as a whole are deciding that what is healthy for them is not necessarily what the magazines and the television tells them, and furthermore, this trend is one that is leading them into healthier lifestyles. With more interest nutrition and good exercise, plus sized women are finding that their shape may be perfect for them, and now there are other sources telling them this too!
If you have been holding back on shopping for a while, hold back no longer! There are plenty of different places for you to search out clothes that both look great and feel great, and if you are in a position to do some shopping, now is a great time to jump right in.
The right pair of denim jeans may be the single most important piece of clothing in your wardrobe and will without a doubt be the most versatile piece in your collection. Plus size denim lines are ever increasing and the trend focused options available in standard sizing are rapidly becoming available for the plus size community. From your favorite tee to a kimono top, your entire look can be changed without ever taking off your denim. However, what looks stylish and sexy on one woman, makes another one look frumpy or outdated. So, how do you know what's right for you? Below are some basic guidelines to follow when shopping for the perfect piece of denim.
The golden rule is: Know what thyself is workin with! If you got it flaunt it, accentuate the positives. Booty like J Lo? Mile long legs? These are the features you want to accentuate. Work with different washes and of the minute denim shapes like boot-cut and wide leg that enhance your favorite features.
What is your body style? Wide Hips, avoid the temptation of drowning yourself in relaxed fit jeans, they will only add inches where you're trying to lose them. Instead draw the eye down and balance the body with a pair of slight flare boot-cut jeans in a mid rise that's fitted throughout the hips. If you have short legs, make sure you pay attention to the length; this is one of the most important aspects when choosing a pair of jeans. Denim should be about a half of an inch above the ground when wearing heels or flats. Darker washes, with a front crease from the knee to the hem, also elongate your legs. A new option re-emerging is the higher waist trouser jean, which not only slims, but creates the illusion of mile long legs. Girls with a boyish figure or a body style considered to be rectangular will want to opt for a cut that will add the illusion of having curves, such as a mid-rise flare leg jean, where the denim is fitted through the hips and thigh, with the flare beginning above the knee.
The devil is in the details; you will want to consider different details of the jean itself. A fan of distressing and aged denim? Make sure not to go overboard. Extreme fading or jeans that appear to be destroyed may be popular with 15 year old pop tarts, but in reality can look tacky and dated. Dark denim in a crisp shape is always chic, as is a medium wash with well placed whiskering. Pay attention to pocket shape and angle. Hexagonal shapes that angle in towards the center tend to work best in creating a heart shaped booty for any body. Pockets placed slightly higher on the tush tend to make a flat booty look perkier and higher. Flap, or cargo pockets, also add some oomph to a small tush. Long pockets that pass the bottom of the tush are fantastic for shaping and lifting an ample booty. Avoid excess fading on the butt and the thighs, as they will make these areas look larger. Also pay attention to a lot of whiskering around the zipper area, which can also accentuate the hips. When considering rise, most women will be best served by a mid rise (a few inches below your belly button).
When choosing the right pair of plus size denim know your body type first and foremost, it is the basis of your search. Know which styles will work with your type and most importantly, what makes you feel fabulous.
The fashion world is a fickle mistress. Things go in and out daily. One day the fashion gurus are declaring that plaid is the new black and suddenly all over New York City mannequins covered in plaid from head to toe suddenly appear in store windows up and down the Garment district. Fashion is fleeting but every now and then a style emerges that takes hold in the minds and hearts of fashion critics the world over. These consistent fashions are giants in a crowd of diminutive and evanescent fashion trends. One of these dependable fashion trends is that of distressed jeans.
Distressed denim is the name for jeans that are designed and manufactured to appear well worn. As if they'd been worn to a hundred rock and roll concerts or washed and folded a thousand times. This style represents the laissez faire, laid-back mentality of today's generation. If the smiley face t-shirt defined the 90s its clear that the distressed jean will define the 2000s. Hundreds of thousands of twenty something's walk the streets of New York City wearing graphic tees and distressed denim jeans and this trend shows no signs of stopping.
How can one get in on this fashion trend? It's easy. There are two options. The first option is to buy a pair of non-distressed jeans and wear them until they're falling apart at the seams. This option is cost-effective but the reality is who really wants a pair of jeans that are falling apart at the seams? The second option is far more pragmatic. Quite simple one could simply buy jeans styled to look and feel like well worn jeans but with the dependability one would assume comes along with buying brand new denim jeans. If one were to take advantage of the second option they'd be able to enjoy the best of both worlds! Comfortable and dependable fashion all rolled up into one.


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Playing Fruit Machines
First of all, it is often better to get to know a game which includes the Casino Mate Pokies games prior to you play it, especially for cash. Ironically, you often see folks that happen to be new to Casinos end up losing capital, simply since they do not have an understanding of the Online Pokies.
They'll make a max bet with no understanding what the amount is going to be, and sometimes a $20 bill can only give 3-4 spins. It really is a fast method to run out of funds. This is just one of the reason why practicing on the fruit machine games is really a superior notion.
The reason to practice on Internet Pokies is it would let you know it more. In case you have to produce a choice throughout the game, then you must have some information from the game itself. By way of example you could be offered the option to take an additional spin or a distinct amount of winnings. Should you know slightly in regards to the fruit machine games then you will be in a far better position to establish what might be one that is most likely beneficial for you.
Bonus Function
The Rainbow Riches fruit slot gives a bonus function recognized as the Road to Riches. This needs the player to end up with 3 leprechaun hats within the winning line. If the player does indeed reach this point, then he or she has won an enormous amount of income.
Gold Symbols
One more function with the game that keeps the player playing with the earnings flying, is the gold symbols. The jackpot might be represented by the pot of gold or the rainbow. Collecting the gold symbols also keeps the player occupied, in no way losing interest within the midst of his or her journey for the finish.
There are a lot of slot machines available online such as the Lions Lair Pokies. Take time to scroll between them for you to find the one that suite you.
What do you think? Your comment:
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Event a big show of support for Elyria High marching band
Joe Medici and Rania Shakkour
The Chronicle-Telegram
ELYRIA — The Elyria High School Pioneer Marching Band Appreciation Day started off hot — literally.
Temperatures hit a high of 82 degrees during the morning and early afternoon hours as residents relaxed in the sunlight, with Jimmy Buffett and James Taylor tunes playing in the background.
"This is what Memorial Day weekend should be about," said Gabriel Munoz of Elyria. "Sitting back on a nice day and enjoying some festival foods."
Several groups of students from local schools made their way through the festival, visiting the assorted tents, grabbing free colored pencils and, of course, making the obligatory stop for an ice cream cone.
By midafternoon, however, it was a different story as dark clouds and high winds blew through Ely Square.
A severe storm warning momentarily prompted several volunteers from the Elyria Schools to take down some of the tents, fearing the high winds might topple them, but school spokeswoman Amy Kren said she still had faith that the concert at night would be a go.
"They just lifted the storm warning, and I have heard that the bulk of the bad weather is south of us, so hopefully we will still be able to hold the concert and the Community Top 10 Awards," Kren said just before 4 p.m.
By 5 p.m., the skies had cleared, paving the way for a pleasant evening concert.
Just before the marching band performed, parent volunteers were handing out 1,000 pink cookies. Children and adults raised their hands in anticipation of the popular cookie. The schools' food services have been making the cookies for years, and they have become well-known among students.
About 1,200 proud parents, alumni and community members were at the 8 p.m. performance.
Marsha Gibson, mother of senior Traci Gibson, a quad drum player, said she was proud of her daughter.
"This is her last performance," Marsha choked. "It's just a proud moment."
The band opened by showering the crowd with inflatable balls, Frisbees, batons and silly string.
Pete Veliconia's daughter, a sophomore flute player, also performed.
"I think it's a great way to share their gift of music," he said.
Contact Joe Medici at 329-7152
or firstname.lastname@example.com. Contact Rania Shakkour at 329-7127 or rshakkour@


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Remember last summer when Jerry Stackhouse got in John Wall's way? Well, check the Top 5 plays from the same NC Pro-Am. There are some gems in here Ryan Harrow, Kyrie Irving, C.J. Leslie, John Henson, Justin Watts and Charles Ward. Oh yeah, and these are just from Tuesday night.
Who's the best player to come out of North Carolina in the past five year?
Follow Aron on Twitter at @the_real_aron.
Follow Dime on Twitter at @DIMEMag.
Become a fan of Dime Magazine on Facebook HERE.


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[caption id="attachment_9414" align="alignright" width="300"] Get together for the troops![/caption]
The stakes were high as the brothers of Phi Gamma Delta at the College of Charleston started planning their FIJI Islander event to support the USO. They knew they wanted to go big in support of America's troops and families. And big they went. They didn't just hold one event. No! They held at least one event every day for an entire week and in the end donated over $10,000 to support USO South Carolina.
FIJI Islander week kicked off on Sunday April 14th with a basketball tournament. The hoops for troops event offered cash prizes and a trophy for the winners. Before the FIJI brothers could reap the success of their first event they were on to event number two. On Monday, students on campus lined up for a rare opportunity to dunk a princess in the dunk tank. As you can imagine, this was a popular event. Later that night the fundraising continued as everyone headed over to Freshberry where a percentage of the proceeds went to support the USO.
Moving on to day three of fundraising, on Tuesday night, a percentage of the proceeds from dinner at Boones supported the USO. Then on Wednesday, a school yard event we all loved as children – a kickball tournament – would get sororities and fraternities on the field together kicking a ball around for a good cause.
This fraternity isn't done yet. On Thursday campus beauties participated in the Princess Pageant complete with talent competition. And Finally on Saturday the big finale FIJI Islander party to celebrate a week of successful fundraising.
This FIJI chapter's donation will go to support troops where it is needed most. Today's USO is always by their side, continuously adapting to the needs of our troops and their families by supporting and comforting, connecting and entertaining in new and imaginative ways. USO's programs and services are made possible by the support of donors like these. - Lisa Ferrari Carter, USO Relationship Manager, Clubs & Organizations
More from the USO
Sep 21, 2017
Cast of NBC's 'The Brave' Shows Support for Military on USO Tour
Actors Mike Vogel, Tate Ellington, Demetrius Grosse, Natacha Karam, Noah Mills, Sofia Pernas and Hadi Tabbal, stars of NBC's "The Brave," teamed up with the USO and visited service members at Kirtland Air Force Base in New Mexico.


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Knit Glove, Poly/Cotton, 2 XL, PR
CONDOR| Zoro #: G0057461| Mfr #: 4NML3
Zoro #: G0057461Mfr. Part #: 4NML3
$0.79 /pr
Orders over $50.00 ship free. DetailsStandard ground shipping
Technical Specifications
|Zoro #: G0057461 Mfr #: 4NML3
|Application: General Maintenance, Material Handling, Assembly, Shipping, and Receiving
|Sold As: Pair
|Item: Knit Gloves
|Size: 2XL
|Color: natural
|Material: Polyester/cotton
|Gauge: 7
|Coating Coverage: Double Sided
|Grip Pattern: Dots
|Grip Material: PVC
|Country of Origin (subject to change): China
Product Description
Ambidextrous Knit Gloves, Material Polyester/Cotton, Size 2XL, Color Natural/Black, Gauge 7, Grip Material PVC, Grip Pattern Dots, Coating Coverage Double Sided, Application General Maintenance, Material Handling,Assembly,Shipping,and Receiving, Sold As Pair, 1 Pair
Restrictions and Compliance
- *1 : California Proposition 65 : This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.
- *2 : California Proposition 65 : This product contains a chemical known to the State of California to cause cancer.


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'Natural Law' ImagesBy Amy
April 20, 2001 - 7:01 AM
A day after revealing a new promotional poster for the episode, UPN has released three new photos and a synopsis for 'Natural Law', set to air May 2.
In a break of their trend from recent times, the site is displaying all of its photos from the episode. Two of the photos, plus the synopsis, may be found on this page, while the third image, a picture of a bedraggled looking Seven with one of the tribesmen, may be found here. Please note that these images are property of Paramount.
On their way to an intergalactic conference, Seven and Chakotay are deterred by an intense force field surrounding a planet. Blasting through to the surface, they find they're without communication to Voyager, with the delta flyer in shreds and isolated in the middle of a primitive society of hunter-gatherers.
Discuss this news item at Trek BBS!
Add TrekToday RSS feed to your news reader or My Yahoo!
Also a CSI: Crime Scene Investigation fan? Then visit CSIFiles.com!


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Lynchburg's White Hart Cafe to Re-Open With Help From Volunteers
Lynchburg, VA - The White Hart Cafe in Lynchburg is closed; its doors though, are wide open.
Inside, volunteers are spending time and money to bring the popular coffee shop back to business. The new owner says he was such a fan of the original; he couldn't stand to see the cafe go.
So with a little help from friends, and a lot of help from strangers, the shop is now set to re-open on September 13th.
The owner, Abe Loper, saying new floors, paint, and upgrades could cost tens of thousands, but thankfully the help has been plentiful.
"If I opened that door at 9 o'clock in the morning, I will meet three or four new people that I have never met before in my life who are going to show up and say can I have a paint brush and help, can I scrape something, can I scrub something?" said Abe Loper, the café's new owner.
The cafe will open just in time for the "Get Downtown" Street Festival. If you'd like to donate to the White Hart's rehabilitation, visit this web page that was set up to take donations.


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Dumbass: Johnnie Gooden Jr. was arrested after claiming to be the newly adopted son of First Lady Michelle Obama and asking a teller at a Chase Bank branch in Bryan, TX, to give him access to her account. The bank teller asked Gooden to leave, but he refused despite being told Mrs. Obama didn't have an account there. He was arrested after police were called on reports of a 'suspicious customer.'
The Houston Chronicle reports Johnnie Gooden Jr. told police that "Mrs. Obama contacted him through Facebook and adopted him and he was now trying to get money out of her bank account."
It's no surprise to learn that this 'genius' has outstanding warrants for resisting arrest and assault on a public servant. He was also charged with pot possession after police found a bag of marijuana in his shorts pocket.