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Whenever you come together
The primary focus of this blog – and my primary academic focus over the last few years – is church gatherings. Even more narrowly, I have been asking the following question: "According to the New Testament, why should believers gather together as the church?" (For that reason, just over five years ago, I named this blog "The Assembling of the Church.")
Obviously, when you begin to study the gathering (or assembling) of the church, many other ecclesiological issues become important, not least of which would be leadership, fellowship, community, spiritual gifts, Lord's Supper, baptism, and many, many more issues. In fact, a person's understanding of the nature of God, of Jesus Christ, and of the Holy Spirit will affect the way that person gathers with other believers. And, in reverse, the way a person gathers with other believers demonstrates what that person understands about God, Jesus, the Spirit, salvation, etc. (In fact, the way people gather together often says more about their beliefs than what they state concerning those beliefs.)
In the modern church, you will find two primary reasons given for the church to gather together: 1) worship or 2) evangelism. Both of these fall short of the scriptural evidence. First, according to Paul and other writers in Scripture, every aspect of the life of a child of God is to be worship. Second, since we're talking about the church (i.e., those who are already God's children), then evangelism is not needed – they have already been evangelized. (This does not mean that believers should not work together for the express purpose of proclaiming the gospel to unbelievers, but this should not be called a gathering of the church.)
So, according to Scripture, for what purpose should believers gather together?
Paul answers this question very succinctly in 1 Corinthians. Now, when reading this letter, it is clear that the Corinthian church has many problems. Some of those problems surfaced when they gathered together. Paul addressed these issues in 1 Corinthians 14, as part of a longer section in which he addresses spiritual gifts.
However, from a grammatical and discourse standpoint, 1 Corinthians 14 – and especially the last half of the chapter – are the focus of this teaching on spiritual gifts in 1 Corinthians 12-14. Thus, Paul began teaching on spiritual gifts in 1 Corinthians 12:1 so that he could get to 1 Corinthians 14:1 and begin instructing them about meeting together.
So, according to Paul, why should believers gather together:
The one who speaks in a tongue builds up himself, but the one who prophesies builds up the church. Now I want you all to speak in tongues, but even more to prophesy. The one who prophesies is greater than the one who speaks in tongues, unless someone interprets, so that the church may be built up. (1 Corinthians 14:4-5 ESV)
So with yourselves, since you are eager for manifestations of the Spirit, strive to excel in building up the church. (1 Corinthians 14:12 ESV)
I thank God that I speak in tongues more than all of you. Nevertheless, in church I would rather speak five words with my mind in order to instruct others, than ten thousand words in a tongue. (1 Corinthians 14:18-19 ESV)
What then, brothers? When you come together, each one has a hymn, a lesson, a revelation, a tongue, or an interpretation. Let all things be done for building up. (1 Corinthians 14:26 ESV)
In each of these passages, Paul continuously and consistently stresses the same point: when you come together as the church, you should seek to build up (edify) one another. Notice that building up others is more important to Paul than manifesting some gift of the Holy Spirit. (He says it's better not to manifest a gift of the Spirit if that gift only builds up the individual.)
Why is prophesy to be preferred over speaking in tongues (uninterpreted) when the church meets? Is prophesy inherently better than tongues? No, they are both manifestations of the Holy Spirit. But, when the church meets, exercising gifts of the Holy Spirit is not to be our goal. Our goal – our purpose – is to edify one another. So, prophesy is preferred over speaking in tongues when the church meets because the whole church can be edified through prophesy.
These statements are incredible in their scope. Paul says that when gathering with other believers – in fact, any time you are gathered with other believers – you should seek to edify one another, mutually. Paul does not leave an opening from some gatherings of believers in which mutual edification is NOT the purpose. The point of this entire chapter is clear: anytime we are with other believers, it is all of our responsibility to help one another grow in maturity in Jesus Christ. This is not the responsibility of some; it is the responsibility of all.
And, it is in this purpose of gathering together (mutual edification) that we understand Paul's previous instructions concerning spiritual gifts (1 Corinthians 12) and love (1 Corinthians 13).
Can we come together for other purposes? Well, sure. We can come together for many different numbers of purposes. But, if we wish to follow the examples, principles, and instructions that we find in Scripture, then we will only come together for the purpose of building one another up.
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Comments are closed. If you would like to discuss this post, send an email to alan [at] alanknox [dot] net.
I've run in to a lot of people who argue that the instructions laid out in 1Cor 14 are for that specific church or that specific era and that the church has "evolved" from it "primitive" state. Both of those points might have some weight to them but it seems to be what Paul instructed in chapter 14 is a direct application of his core theology of the church found in 12 and 13. Any approach to ministry or gathering should grapple seriously with how the church was designed to work. It is clear, as you have pointed out that according to Paul the people of the church minister to each other through Holy Spirit empowered gifts in love.
Any approach to church gathering that limits the participation to a select few and/or makes it difficult for people to even get to know each other is running against the grain of God's design.
To date this post has had the most impact on my life and thinking about the purpose, form and structure of the church! I recently was part of a new church plant, which looked like it was going to be different from other churches I had been involved in: the focus was to be on smaller "community" groups that really would be the gathering of the church, somewhat as you described here. Yet the promise, one full year later, has not been realized, and I don't think it will. I begin to think that what is important to most Church leaders is control and image. Lots of small groups mutually edifying themselves is not controllable by a human organization. I know I am painting with large brush strokes. But it occurs to me that this is Jesus' church, not a particular pastor's church, and most men put in the position of leadership in the church don't seem to trust God with it. At least in Western Christianity, though I suspect because of the corruption of mankind that this is a problem in the universal church.
My somewhat radical, and perhaps overstated thought is that we need another reformation. Luther's took the mass from the center and put the Bible. I think we need to take the Bible out of the center and put Jesus in. That probably sounds much more radical than what I mean. Notice I do not suggest taking the Bible out of the Church, but rather undo the renaissance and the elevation of education, the weekly lecture by one man or group of men, and substitute mutual edification, which will of course heavily rely on the Bible, but from many who all have Christ indwelling them, and rely also on their life experiences / lessons.
- Zombie Women Unite! « Theological Zombie Student - [...] supporter of this blog and an excellent fellow zombie theologian, Alan, asks why the church gathers, or why it…


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Campbell School, Algansee
Twp., 1925-1926
Left to Right: Back Row: Letha Luxenburger, Mary Frick,
Albert Wentworth, Murl Wentworth (teacher), Lois Burkhart, Lawrence Widler.
Front Row: Clark Sherman, Vera Marsh, Donna Dell Burkhart, Shirley Giffey, Leonard Gottschalk, Roy Gottschalk.
Source: Permission obtained from
The Branch County Historical Society from their book
"History of Branch County, Vol. 2", ©1984, p. 131

subset: commoncrawl


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Man airlifted after being ejected from vehicle in Yellow Medicine County rollover accident
Man ejected from vehicle in roll-over
GRANITE FALLS — A 28-year-old man was transported by North Memorial Air Care for injuries suffered after he was ejected from a vehicle in a roll-over accident at 2:30 a.m. on Sunday in Yellow Medicine County.
Dean Nething was not wearing a seat belt when the 2003 GMC SUV that he was a passenger in rolled multiple times on 570th Street south of 120th Avenue, southeast of Wood Lake, according to the Yellow Medicine County Sheriff's Department.
Briana Nething, 28, was driving the vehicle southbound on 570th Street South. She was transported by ground ambulance. She was not wearing a seat belt.
Alcohol and excessive speed are believed to have been factors in the accident, according to the sheriff's department. It remains under investigation. The sheriff's office and North Memorial Air Care were joined by the Cottonwood and Granite Falls Ambulance and Wood Lake Fire and First Responder units in responding to the scene.


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Bob Cole Divisional Quarterfinals: Philadelphia vs. Winnipeg
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I don't see anything in Kennedy's bio that said he killed penalties.
SI, Heart of the Leafs - Scott Young
It isn't hard to account for Kennedy's greatness. A serious, taut young gentleman of 29 (5 feet 11 inches, 180 pounds) with a skating style more notable for strength and maneuverability than for grace, he has the color that makes Yogi Berra great in baseball and a team-lifting type of leadership that makes Toronto fans very relieved to see him out there every time the going is tough. In addition to his regular turns at center on his own line, he is used both on the Toronto power play (for scoring punch when the opposition is short-handed due to a penalty) and on penalty-killing duties when the Leafs are short-handed and need their best checkers on the ice. On top of this, as team captain, he argues every arguable decision with referees and is put on the ice every time there is an important face-off, because he is the league's best at getting the draw when the puck is dropped. All in all, a very busy young man.
Also, Wikipedia cites Nickleson, Al (April 5, 1954). "Leaf's Ted Kennedy Announces Retirement". Globe and Mail: p. 23 that "along with his regular shift, he would also kill penalties". How many strong defensive players that are fantastic at faceoffs don't kill penalties?
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I'm having my best hair day so far today, its dance around the house happy kind of good, so I thought it would be a good day to do a 10 week cg before and after. The blonde pictures are from my first couple if days cg, and the brunette are from today.
Attachment 35041
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A punt snap flying over Steve Weatherford's head. Three punt returns for touchdowns, all 80 yards or more. No. 25 overall in average kick return yardage (21.2) and No. 25 in average punt return yardage (6.1).
The Giants are also tied for first with three punt return fumbles.
Tom Coughlin has seen the special teams miscues spread rapidly this season, and heading into a lengthy self-scout at the bye week it will undoubtedly be on the docket.
When asked if coordinator Tom Quinn's schemes were at fault, here was Coughlin's answer:
"No. I don't think schematically, I don't believe, is the answer," he said. "We've had the punt returns, which unfortunately sometimes we've out-punted the coverage and there's no more explanation than that. A couple of weeks ago, I discussed thoroughly on. I don't need to go there any longer, but hopefully we've gotten that part of it under control."
We'll have more on this tomorrow when Quinn and Larry Izzo will address the media. What questions do y'all have for Quinn and Izzo?


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Hi There! Is this Your First Time?
Did you know if you Register you have access to free search tools including the ability to save listings and property searches? Did you know that you can bypass the search altogether and have listings sent directly to your email address? Check out our how-to page for more info.
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- Price$1,050,000
- Sq. Ft.10,800
- Acres0.25
1936 Grove St Denver, CO 80204 - $1,050,000
Lot strictly marketed for redevelopment opportunity. Zoned G-MU-3. Lot size is 10,800 sq. ft. Property showings will be scheduled with LOI or offer. 7-8 unit development is likely. Buyer to perform due diligence.
Provided by: LIVE URBAN REAL ESTATE
Essential Information
- Price$1,050,000
- Square Footage10,800
- Acres0.25
- Taxes$3,122
- HOA Fees - Secondary$0
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- TypeLand
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- CityDenver
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- Zip Code80204
- Lot Description10800.00
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- ZoningG-MU-3
Terms and Conditions: The content relating to real estate for sale in this Web site comes in part from the Internet Data eXchange ("IDX") program of METROLIST, INC., DBA RECOLORADO® Real estate listings held by brokers other than LIVE Urban Real Estate are marked with the IDX Logo. This information is being provided for the consumers personal, non-commercial use and may not be used for any other purpose. All information subject to change and should be independently verified.
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Can't finf screen print packages in repositories.
Thanks to all for the quick response and suggestions for a screen capture program. I've tried to find Winsnap, Capture, Xvidcap and Screen Capture using "Puppy Package Manager" but, I couldn't find any of them. Now what am I doing wrong?
It's been a bad day!
Puppy mostly comes with ffmpeg pre installed and newer Puppy ffmpeg likely supports the x11grab feature .
How To Use FFMPEG To Screencast from any Puppy Distro
Wary: ffmpeg improved
I am using Puppy Slacko 5.5 and it seems a screen print utility is already part of that distro.
to access the print screen utility, just press the Print Scr key on the keyboard.
You may have to also pres the Shift key as part of it.
|All times are GMT -5. The time now is 12:55 PM.


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PlayStation 4™|Playstation Vita™|PlayStation 3™|Xbox One™|Xbox 360™|Nintendo Switch™|Nintendo 3DS™|PC Games|Other systems
Diamond Trust of London
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Compatible with Nintendo DS™ (NDS™)
Get informed when this item is in stock by using our Personal Agent from the right.
Works on all systems sold worldwide.
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Works on all systems sold worldwide.
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sold Out of print / Out of stock
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- From the acclaimed game designer Jason Rohrer
- Fly in and out of Angola to buy diamonds from 6 diamond-producing regions
- Direct your agents through 8 rounds, each counting as a month during the lead-up to inevitable UN regulation
- Play single-player mode against the various skill levels of AI or a 2-player Wi-Fi game between 2 nearby DSi units
- Use the DSi camera to snap a picture of your opponent's vault to see if it has been compromised
- Subvert your opponent through secret decisions as you bid on diamonds, pay salaries, and offer bribes
descriptionThe finest diamonds in the world are hidden here. Not hidden, actually, but dug out of the earth by the teeming masses. The diamonds are hidden only to those who are too afraid to come here to Angola, too afraid of conflict. The local market has been soft ever since the biggest player went back to Johannesburg, but we still fly under the radar. We're made-up corporations with made-up names; we have no permanent employees and we work in temporary offices. These temporary offices though, are in the only places that matter for diamonds: Antwerp and London. There are only two firms left with agents in Angola, and we have until December before the UN starts regulating the sale of rough diamonds. Let's make these last 8 months count.
Diamonds for Nintendo DSi is a two-player, turn-based strategy game. The action is based on the dealings, secrets, and espionage of two diamond trading corporations in Angola, a nation rich with diamonds but torn by factional conflict. Each player controls a corporation that deploys hired agents into the region to purchase diamonds. Agents maintain certain corporate secrets about their dealings, but their loyalty is for sale.
further info
|Official Release Date
|Aug 07, 2012
|ESRB Everyone
Titles rated E (Everyone) have content that may be suitable for ages 6 and older. Titles in this category may contain minimal cartoon, fantasy or mild violence and/or infrequent use of mild language.
|Item Code
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SN: 222 | 1007 { 58 } | | WS: 1 | | Cat: 638


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OAKLAND, Calif. — New Golden State Warriors coach Mark Jackson started to explain his plan for a shortened training camp when general manager Larry Riley's phone rang.
"I hope that's a couple of free agents," Jackson joked.
Riley laughed, placed the phone back in his coat pocket and whispered that it "wasn't easy" to ignore the call. The two finished talking with reporters and, before they could return to the basketball operations offices, the phone started ringing again.
Welcome back.
"All of the other things to building a great franchise have taken place, but we haven't been able to do much with basketball," Riley said. "So now, so to speak, it's time to go."
While the reconstructed Warriors management returned to Oracle Arena on Thursday, most players are not expected at the team's practice facility in downtown Oakland — now open again — until next week. Preparations for their return are already under way.
Riley has been busy fielding calls about potential moves. New assistant general manager and eventual successor Bob Myers took a flight to Los Angeles to talk to agents at his old stomping grounds at the Wasserman Media Group and new executive board member Jerry West stayed in contact with everybody.
Just don't expect any major changes anytime soon.
Although trade talk has surrounded leading scorer Monta Ellis for years, breaking up the point guard tandem with Stephen Curry still seems an unlikely possibility at the moment. Riley said he will do his "due diligence" exploring possibilities with the roster but doesn't anticipate a major overhaul before the season begins Dec. 25.
"What's the likelihood the roster will be near the same with some additions on opening day? Very likely," Riley said.
The statement seemed to indicate Jackson will be working with the same incomplete roster as his predecessor, Keith Smart, ousted after one year as a fill-in coach under the new ownership group headed by Joe Lacob that has promised sweeping changes to the underachieving franchise.
The Warriors have made the playoffs just once since 1994. About the only success the franchise has enjoyed is that long-suffering fans in the basketball-crazy Bay Area still regularly pack the arena and can be as vocal as any in a market saturated with sports teams.
Ellis, Curry and forward David Lee are the core of a Golden State team that finished 36-46 last season, a 10-game improvement from the previous year. While moving one of the three will likely be necessary for any overhaul, doing so under the rushed offseason free agency will be tough.
In time, Riley believes bigger changes will come.
"Now will tomorrow or next week show a lot of change? It could be, because we don't know exactly what we're dealing with and what additions we're making to the team," Riley said. "But this organization has a lot of confidence that our future is good. And I'm not talking about 10 years from now. We're not talking about that. We're talking about short-term future."
Then he turned to Jackson and muttered, "I hope you agree with that."
"Absolutely," Jackson replied. "I wouldn't be sitting here. Somebody else would be sitting here."
The first-time head coach has his own obstacles to overcome.
The only preaching Jackson could do all summer and fall is at his ministry in the Los Angeles area. He held meetings with his new coaching staff in Oakland and a "boot-camp" style one in Southern California one week to overload them with information.
"I think it would've been a nightmare if we didn't have basketball back," Jackson said.
Training camps are scheduled to open Dec. 9, under the parameters that a new collective bargaining agreement will be ratified in time. In the meantime, Jackson and his coaching staff are not permitted to have any contact with players who might be hanging around the facilities.
Jackson is using the time wisely.
He stopped by the San Francisco 49ers headquarters to speak with Jim Harbaugh this week and has another meeting in the works with Oakland Raiders coach Hue Jackson. The first-year NFL head coaches have had remarkable success in turning around the two Bay Area football franchises, and they did so despite a work stoppage that shortened training camp.
Jackson hopes to duplicate the success on the hardwood.
"The reason I wanted to do it is because of the great success both those guys have had in changing the culture. Great leaders. They've turned things around. They've made it the same things that I look forward to making this — team, we, collective, buy in or you're out, having fun," Jackson said.
"Neither one of those coaches used a shortened preparation time as an excuse," he said. "Neither one of those staffs. And we won't either."
Follow Antonio Gonzalez at: www.twitter.com/agonzalezAP


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By Jan Lee Buxengard
Caledonia Argus
Zion Evangelical Church in Brownsville will celebrate its 150th anniversary on May 4 through 5. It is a time for the people to remember God's faithfulness throughout the generations; a time to rejoice in God who makes us, sustains us and carries us forward; and a time to renew your own commitment to the kingdom of Christ, according to church leaders.
Events of the weekend start with a cemetery walk on Saturday, May 4 beginning at 2 p.m. The schedule on Sunday, May 5 begins with 10 a.m. worship at the church, followed by a noon luncheon (by invitation) at the Brownsville Community Center and a 2 p.m. anniversary service at the church.
The Rev. Jason Brannan is the current pastor of the congregation, which has a long history of faithful people.
In the early 1850s settlers who left their homes in Germany re-established themselves in the Brownsville area. These immigrants, who shared a background of Evangelical Lutheran faith and considered faith the center of their community, began meeting in each other's homes for worship services and later, as their numbers grew, gathered at the local school house.
During those early years they were served by Lutheran pastors from La Crosse until 1862 when the Rev. Fachtman from La Crosse assisted them in forming a congregation. That fall this group of Christians agreed to purchase a lot for $50 and began building a wood frame building as a permanent house of God. The structure, built at the cost of about $800 and completed the following spring, was modest but a place where all could gather and worship God.
The congregation chose "Deutsche Evangelische Lutherische Zion's Kirche" (German Evangelical Lutheran Zion's Church) as its name.
A small house in back of the church was purchased in 1863 to serve as a parsonage. The Rev. Ludwig Ebert, who also served churches in La Crescent and Crooked Creek, became the first resident pastor.
His first recorded baptisms were on December 28, 1862, when he baptized the three sons of Mr. and Mrs. Johannes Jakob Harer in their home. The first church baptism was Johanna Keller on March 1, 1863. The first recorded marriage was that of Andreas Ernst Wonhof and Maria Bader in August of 1864. A double wedding ceremony in October of 1865 united Jakob Meinzer and Maria Geiwitz and Jakob Geiwitz and Maria Meinzer. The first confirmation took place on April 3, 1864. There were 20 participants in the first communion held on Christmas 1862.
A growing congregation
An additional lot north of the church was purchased in 1895 and a school house built beside the church where Sunday school and confirmation classes were taught by the minister, all in German.
The growing congregation needed a larger sanctuary, so in 1904 the church was remodeled and made larger and a new reed organ purchased. A steeple was added over the entrance, including a large bell with the inscription "Geshenk des Jugenvereind der Evangelische Lutherischen Zion Gemeind" (Literally: gift from the youth group of the Evangelical Lutheran Zion Congregation.) Hitching posts, connected by heavy chain, provided a place for the teams of horses to be tied.
A new wing or fellowship hall was added to the white church in 1957 to provide space for a growing Sunday school. Volunteers from the congregation provided most of the work on the new building.
By the late 1970s the need for a new sanctuary brought about another building project, as the old church building was deteriorating. During construction, which began in November 1979, church services were held in the fellowship hall. The original altar, pulpit and baptismal font were placed in the new building, and the original bell now had a prominent spot in front of the structure. Dedication of the new sanctuary took place on June 15, 1980.
There have been various fundraising events such as fish fries, dinners, brunches, the sale of four cookbooks and more. Their annual roast pork and sauerkraut supper has been a tradition at Zion for over 70 years.
Name changes
On Jan. 25, 1864, a constitution was adopted, but the church was not officially a part of any synod of Minnesota. Twenty-five years later in May of 1889 a revised constitution was made to conform to the Evangelical Synod of North America, and the church became a member of the Minnesota District and became Zion's Evangelical Church.
In 1938 the Evangelical Synod added "Reformed" to their name, so the church became "Zion Evangelical and Reformed." A merger between this denomination and the Congregational Church changed the name again in 1957 to Zion United Church of Christ. In 1975 the congregation dropped their affiliation with the U.C.C. and once again the little white church became Zion Evangelical Church. At that time a new constitution was written, a Statement of Faith was adopted and Zion became an independent church.
Shared pastors
Peace Church at Crooked Creek joined with Zion in 1886, and two years later Zion Church at Hokah was added to the union, all being served by the same pastor. This meant a great deal of traveling and in horse and buggy days it was impossible for the minister to be in each church on the same Sunday. After a 50-year period the three point charge was dissolved because the congregations desired weekly instead of monthly services.
From 1964 to 1984 Zion Evangelical Church in Brownsville and Zion Evangelical Church in Hokah once again shared a pastor; however, they separated again in 1984 when the congregations had grown to the point where they felt they needed a full time pastor of their own.
Ministry and faithful service
Zion Evangelical Church has had many wonderful pastors and the members are grateful for their leadership and ministering.
Organizations and groups within the congregation continue to provide Christian fellowship, support and leadership for the church. There are opportunities for education, teaching, Bible study, ministering, music and fellowship for people of all ages.
Over the years the church has sponsored radio and nursing home ministry, missionaries and a variety of missions, both at home and abroad.
Zion Evangelical Cemetery
"Gottesacker," translated "God's Acre," was the name given to the three-acre parcel of land deeded in October 1866 to trustees of the German Lutheran Church as a final resting place for members of Zion Evangelical and the Church of the Holy Comforter.
"The cemetery walk on May 4 is a way to share memories of those who have gone on," commented lifelong member Kathy (Ideker) Fitzpatrick.
"We are told God wants us to stop, pray and listen to what He wants us to do," stated Lorene (Wohlers) Miller, "and then step out in faith to do His will."
The celebration is a time to remember, rejoice and renew.


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It's the part of Denver nicknamed "The Hell Hole†– a section of Denver that rarely makes the news unless it's bad news.
On Saturday, several black churches from Denver gathered in the McIntosh neighborhood off N.C. 16 to change that negative perception.
They held a block party to reach out to the community with a message of hope and Christian love in what was termed the "McIntosh Project.â€
According to organizer Lewis McLean, a member of Rock Hill United Methodist Church on Old Plank Road, 19 churches were invited to participate in the event that ran 11 a.m. – 3 p.m.
"As of lunchtime, we had five churches here participating,†said McLean. "I sent out fliers and even talked to other church's representatives at different functions.â€
The event was a first both for the churches that participated and the community, where about 50 people turned out for music, food and ministry.
"It's a perfect time for missions work between Lent and Easter,†said Rock Hill UMC pastor Frederick Bowman. "It was a strong commitment from Lewis and his leadership that made this happen. It's a way to build bridges in the community.â€
Pastor Franklin Lowery of Gold Hill Baptist Church called the turnout "wonderful†despite all of the negativity in the neighborhood.
"We can have all the classes and seminars in the world but we need God to change people's hearts,†said Lowery.
Lowery also said what's important for the Church as a whole is what is done to reach out to people.
"There's too much in-house ministry and not enough outside the church walls,†he said. "We have to do what's needed and this is something that takes effort.â€
He added similar projects like the "McIntosh Project†can go on "as a joint effort continuously.â€
"It's about Kingdom building,†said Lowery.
Pastor W.J. Neal of Christ Missionary Church in Charlotte came to the block party with free clothes for the neighborhood.
"It's important to be here today,†he said. "It's a great commission God has given us to preach to the people in the community. We want to be able to reach out and lead people to Christ. This is the best way to reach unchurched people.â€
Gilbert McLean of Rock Hill UMC agreed with Neal's sentiment.
"We're here to let people know that the Church as a corporate body is here for them,†he said.
He added that several people from McIntosh has been coming to Rock Hill UMC.
"We wanted to be sure that they still come,†said McLean. "We hope to let the people know that we care.â€
Rock Hill UMC pastor Frederick Bowman also ministered to the crowd on the message of the prodigal son.
"Who's been prodigal. Look around you,†he said. "We're here to help you, McIntoshes. We're here to show you we're prodigals.â€
He added that it's time for the community to wake-up to "its true condition.â€
"God has blessed us and we need to let him know our true condition,†preached Bowman. "People must come to themselves and realize their condition is because of 'little ol' me'.â€
by Jon Mayhew
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WASHINGTON (Oct. 17)
As ground was broken for the United States Holocaust Memorial Museum here yesterday, Senate Majority Leader Robert Dole (R. Kans.) pledged that the Senate would ratify the United Nations treaty against genocide this fall.
"We'll do it this year," Dole told some 700 people attending the groundbreaking ceremony in a huge tent on the site of the planned 300,000-square-foot museum, just some 150 yards south of the Washington Monument.
Dole told the Jewish Telegraphic Agency later that he expected to bring up the treaty on the Senate floor sometime in November and expected it to be approved since President Reagan has urged its adoption and the majority of the Senate favors it.
He said he doubted that conservatives who have opposed ratification since President Truman first sent the Genocide Convention to the Senate in June 1949 would conduct a filibuster since Sen. Jesse Helms (R. NC) has approved several reservations in the bill that would limit World Court jurisdiction.
At the ceremony, Elie Wiesel, chairman of the U.S. Holocaust Memorial Council, thanked Dole for his pledge. "I am not naive to believe that treaties will prevent mass murder, but the absence of such treaties may give the enemy of humankind the wrong signal," Wiesel said. "Would a genocide treaty have prevented the murder of the Jews by the Nazis? I doubt it. But its absence gave the enemy of humankind the wrong signal."
The most moving point of the ceremony came when Wiesel and other Holocaust survivors mixed American soil with soil from the former concentration camps of Auschwitz, Bergen-Belsen, Dachau, Theresienstadt and Treblinka and the Warsaw Jewish Cemetery, to be used in building the foundation of the museum.
The U.S. Army Band played "Ani Ma'amin" during this poignant moment. There was also a processional of divisional colors of the U.S. Army units that liberated the death camps.
Although the U.S. government donated the land on which the museum is being built for a scheduled opening in 1989, the $100 million needed for its construction, equipment and endowment is being raised through a nationwide campaign headed by two Holocaust survivors, Miles Lerman, of Vineland, N.J., and Sigmund Strochlitz, of New London, Conn.
President Reagan is honorary chairman of the campaign, and Interior Secretary Donald Hodel said yesterday that this is a "signal to the entire nation" that the museum is an "important objective of the American people."
Reagan, in a message read at the ceremony by Hodel, stressed the importance of the museum's being built among so many major American monuments. "With our children and our children's children in mind, we are creating on this spot a place of remembrance and warning," Reagan said. He said that "when in the years to come our children emerge from this museum with the lessons of totalitarianism fresh in their minds" they will have greater appreciation of "democracy, justice under God," symbolized by the other monuments.
All the speakers stressed the necessity of remembering the Holocaust in order to prevent it from ever happening again. Dole noted that Gen. Dwight Eisenhower visited one of the liberated death camps so in the future he could bear witness if there was a claim that the Nazi atrocities were not true.
But Dole noted that 40 years later, memories were fading and many survivors had died. He said if it is hard to remember the inhumanity of the Holocaust "think about the fate of Leon Klinghoffer …. Lest we forget for one moment, think about what happened yesterday or the day before or last week as well as 40 years ago."
Wiesel also said that the murder of Klinghoffer by terrorists "is today as abhorrent as state terror was when from Hitler's Berlin, it dominated part of Europe from 1933 to 1945."
Mark Talisman, vice chairman of the Holocaust Council, said the museum will be a reminder not only of the Nazi atrocities against Jews and others but of the silence of governments and people while it happened. "Had they done otherwise, there would be no need at all to be here today," he noted. He said there is no "better place than here at the seat of our government" for the museum "so as to remind us forever of our precious responsibility never to allow the darkness of the Holocaust to be repeated against any people."
Wiesel said that only Israel with its Yad Vashem and the U.S. have national museums dedicated to the memory of the six million Jews who died in the Holocaust.


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are you guys buying these spendy 22 bolt guns ???
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January 15, 2013, 06:00 AM
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I've had an "early" CZ452 Varmint and had a difficult time getting it to shoot well. I finally free-floated the barrel and bedded the action. That made all the difference, but it wasn't the rifle for me.
A a year or so ago, I bought a new/used CZ455, .22WMR and it had problems that I corrected, including bedding, firing pin shape, and trigger pull. It now shoots MOA at 100 yards with the right ammo, but with other ammos varies from 1 1/4 to 3 MOA. I was immediately attracted to the woodgrain of this rifle and apparent newness in the used gun rack. It's lightness and accuracy make it my favorite walk-about rifle.
The 455 is a switch-barrel design, but because I never intend to shoot either .17 HMR or .22LR in it, I LockTite-d the barrel in with Steeve and Bearing Mount. It worked for my Ruger 10-22, and seems to have helped the 455.
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These crunchy golden twice-cooked potato skins are both a fantastic family snack this Christmas or a finger food option for a festive party. No matter when you serve them, they'll always be a hit!
Christmas, Finger food, Party food
Preheat oven to 220C. Wash potatoes and dry with paper towel. Scatter rock salt evenly over a baking tray. Place potatoes on salt and prick each one a few times with a fork. Bake for 30 minutes or until tender.
When potatoes are cool enough to handle, cut into quarters or sixths lengthways, depending on how big the potatoes are.
Throw the rock salt away, wipe the baking tray and arrange potato skins on the tray. Drizzle with olive oil and bake for 20 minutes or until golden and crunchy. Remove from oven, slide into a serving dish and season with salt.
Serve skins with sour cream or yoghurt, and an impressive cocktail, of course.


text: Pokemon Store Korea Jolteon Plush$41.99 Pokemon Store Korea 2017 Jolteon plush. Made of soft polyester. Manufacturer: 3rd Round by Nintendo (Pokemon Store Korea) Condition: Brand New, Unused Item Approx. Dimensions: Height (10 inches) Release Date: 2017 Material: Soft Polyester Only 5 left in stock Add to cart Add to Wishlist Product added! Browse Wishlist The product is already in the wishlist! Browse Wishlist Category POKEMON PLUSH Tag


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Welcome to www.shirenza.co.za!
Shirenza Labrador Retrievers strive to breed top quality, excellent temperament and beautiful dogs altogether with lots of love and dedication. My Labradors are the most loving, loyal and obedient dogs one can own. We live on a farm in South Africa and here my dogs can run freely, playing and swimming. They are also taken for long walks in the fields where they can have the opportunity to retrieve balls and if it may also birds. They are fed on a good diet of Royal Canine and treats. The Retriever's best characteristic is the ability to socialize with little children and their well known "best friend and companion" status make this dog an excellent member of one's family.
Having a Labrador is a 12 year commitment. Read more about it on our other pages.
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Taras Young, cultural professional and award winning hacker reports on #chs11!
By AmbITion
10 May 2011
Over the weekend, I was incredibly fortunate to take part in what was – to my knowledge – the first proper Scottish hack day, Culture Hack Scotland. For those not familiar with the term, a hack day is essentially 24 hours in which a large group of geeks, furnished with everything they need – raw […]


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It only takes a minute to get started. Fill out our simple sign up form and login to the site.
This step is discretionary but will dramatically multiply your chances of getting interest from other over 50s members on the site. Write a little something about yourself, your pasttimes and upload some good photos of yourself.
Use our website's state-of-the-art search to spot over 50s members who satisfy your needs. Or just scan through listings and spot folks that appeal to you.
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- Credit Cards Accepted:
- Days & Hours: Mon.-Fri. 11am-7pm; Sat. 10am-4pm; Closed Sunday
We are conveniently located in the heart of Old Town. We are a Full Service Bridal Boutique with Tuxes and beautiful dresses for all occasions. Our inventory includes distinguishable high couture fashion along with impeccable service.


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Taliban FM Hints Bin Laden Still in Afghanistan
Taliban Foreign Minister Wakil Ahmed Mutawakel said Saturday he was unaware of Osama bin Laden having left Afghanistan before or after an Islamic clerics' resolution that he be asked to do so.
"I have not heard any report that he has left Afghanistan," the minister told AFP.
He was the most senior Taliban official to comment on bin Laden's whereabouts since Thursday, when Afghan Islamic scholars adopted a resolution recommending that the Taliban persuade bin Laden to leave.
Mutawakel said: "The Islamic Emirate has listened to the resolution of the ulema [scholars] and, as usual, paid it the utmost respect."
But he said he did not know if it had been passed on to bin Laden.
A spokesman for the Taliban's supreme leader Mullah Mohammad Omar said earlier he had no idea whether the Saudi-born militant was still in the country.
Bin Laden has been based in or around the Taliban's stronghold in the southern city of Kandahar since 1996 but there has been speculation he may have slipped out of the country earlier this week -- KABUL (AFP)
© 2001 Al Bawaba (www.albawaba.com)


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Raving Rabbids Travel in Time is a hilarious party game where Rabbids travel back in time in a washing machine to the greatest historical moments and mess them up! Play over 20 mini-games with 5 different types of gameplay including flying, dancing, jumping, and pointing games in different historical environments from pre-history to Egypt to King Arthur. You can sabotage your opponents and play seamless online/offline gameplay with up to 4 players. Pick between 30 unique historical costumes, such as Indian, Cowboy, Egyptian, and Musketeer.
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Change of plan as some AHL Syracuse players already on way to Lightning camp
AHL Syracuse general manager Julien BriseBois on Saturday confirmed five Crunch players are headed to Tampa for the Lightning's training camp:
Defensemen Keith Aulie (whom we already knew) and Matt Taormina, and forwards Cory Conacher, Pierre-Cedric Labrie and Mike Angelidis. BriseBois said more players will be recalled after Saturday's game. He also said the five named players will not play Saturday against Rochester and neither will defenseman Evan Oberg, though BriseBois said Oberg will not be at camp.
The names were first reported by the Syracuse Post-Standard.
The announcements and process is different than what Lightning general manager Steve Yzerman recently explained, that announcements would be made after Saturday's game and that there would be no advance scratches. But in the end, BriseBois said he and Yzerman wanted those five players to be able to make Sunday's start of camp.
Aulie, Labrie, Angelidis and Taormina (all on AHL only contracts) will have to clear waivers to get back to the Crunch if they do not earn a place on the Lightning. Conacher, who has an NHL element in his contract) would not need waivers to be sent down.
All this, of course, is dependent on the Players' Association ratifying the new collective bargaining agreement and signing with the league a Memo of Understanding. Both are expected today.


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SOBEFest Events 2013
Link Time: Check Out the Events at This Year's SOBE Wine and Food Fest
- Your guide to the South Beach Wine and Food Festival — Zagat
- Guy Fieri's restaurant has a parody website — Grub Street New York
- . . . and that website is full of a bunch of ripped-off jokes — Eater
- E. coli fears spark a 38-state spinach recall — Delish
- Check out these amazing food GIFs — HuffPost Taste
- Potato and avocado tacos for breakfast — Big Girls Small Kitchen


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Research Topics
J S McCune
Affiliation: University of Washington
Country: USA
Detail Information
- Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics of Immunosuppressants in Allogeneic Hematopoietic Cell Transplantation: Part IIJeannine S McCune
Department of Pharmacy, University of Washington, Box 357630, Seattle, WA, 98195, USA
Clin Pharmacokinet 55:551-93. 2016....
- Pharmacokinetics, Pharmacodynamics and Pharmacogenomics of Immunosuppressants in Allogeneic Haematopoietic Cell Transplantation: Part IJeannine S McCune
Department of Pharmacy, University of Washington, Box 357630, Seattle, WA, 98195, USA
Clin Pharmacokinet 55:525-50. 2016..In Part I of this article, we review the alloHCT process to facilitate optimal design of pharmacokinetic and pharmacodynamics studies. We also review the pharmacokinetics and TCI of calcineurin inhibitors and methotrexate. ..
- Association of fludarabine pharmacokinetic/dynamic biomarkers with donor chimerism in nonmyeloablative HCT recipientsJeannine S McCune
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Cancer Chemother Pharmacol 76:85-96. 2015..In this study, we evaluated whether fludarabine-based pharmacologic biomarkers were associated with clinical outcomes in HCT recipients...
- Population pharmacokinetic/dynamic model of lymphosuppression after fludarabine administrationJeannine S McCune
Department of Pharmacy, School of Pharmacy, University of Washington, Box 357630, Seattle, WA, 98195, USA
Cancer Chemother Pharmacol 75:67-75. 2015....
- Variation in prescribing patterns and therapeutic drug monitoring of intravenous busulfan in pediatric hematopoietic cell transplant recipientsJeannine S McCune
University of Washington School of Pharmacy, Seattle, WA, USA
J Clin Pharmacol 53:264-75. 2013....
- A limited sampling schedule to estimate mycophenolic Acid area under the concentration-time curve in hematopoietic cell transplantation recipientsHong Li
Department of Pharmacy, Box 357630, University of Washington, Seattle, WA 98195, USA
J Clin Pharmacol 52:1654-64. 2012..5, 3, 5, and 6 hours from the start of the infusion precisely estimated MPA AUC(0-12 h) for Q12-hour IV MMF. A comparable schedule (2, 2.5, 3, 4, and 6 hours) similarly estimated MPA AUC(0-8) (h) for Q8-hour dosing...
- Potential of chemotherapy-herb interactions in adult cancer patientsJeannine S McCune
University of Washington, Seattle, WA 98195, USA
Support Care Cancer 12:454-62. 2004....
- Influence of age upon Ifosfamide-induced nephrotoxicityJeannine S McCune
University of Washington Medical Center, Seattle, Washington, USA
Pediatr Blood Cancer 42:427-32. 2004..Ifosfamide-induced nephrotoxicity is well recognized in children, although it has also been reported in adults. Whether ifosfamide nephrotoxicity is more common in children than in adults is not known...
- Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylationJeannine S McCune
Department of Pharmacy, University of Washington, Seattle, WA 98195, USA
Drug Metab Dispos 33:1074-81. 2005..CYP2B6 protein could not be detected in this panel of human renal microsomes. In conclusion, CYP3A5*1 genotype is associated with higher rates of ifosfamide N-dechloroethylation in human liver and kidneys...
- A pilot pharmacologic biomarker study of busulfan and fludarabine in hematopoietic cell transplant recipientsJeannine S McCune
School of Pharmacy, University of Washington, Box 357630, Seattle, WA 98195 7630, USA
Cancer Chemother Pharmacol 69:263-72. 2012..Our goal was to evaluate pharmacologic biomarkers pertinent to both medications in these patients...
- Personalized dosing of cyclophosphamide in the total body irradiation-cyclophosphamide conditioning regimen: a phase II trial in patients with hematologic malignancyJ S McCune
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Clin Pharmacol Ther 85:615-22. 2009..03); and nonrelapse and overall survival rates similar to those in the controls (P = 0.70 and 0.63, respectively) despite the lower doses of CY administered to most of the patients in the personalized dosage group...
- Cyclophosphamide following targeted oral busulfan as conditioning for hematopoietic cell transplantation: pharmacokinetics, liver toxicity, and mortalityJeannine S McCune
Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA 98195, USA
Biol Blood Marrow Transplant 13:853-62. 2007..Alternative strategies, such as administering i.v. busulfan or CY before BU, should be explored...
- Assessment of ovarian failure and osteoporosis in premenopausal breast cancer survivorsJeannine S McCune
Department of Pharmacy, University of Washington, Seattle, 91895 7630, USA
J Oncol Pharm Pract 11:37-43. 2005..Therefore, we conducted a retrospective chart review to determine the adequacy of ovarian failure and osteoporosis assessment and management in premenopausal breast cancer survivors...
- Cyclophosphamide disposition in an anephric childJeannine S McCune
Department of Pharmacy, University of Washington, Seattle, Washington 98195, USA
Pediatr Blood Cancer 46:99-104. 2006..e., 383 microM*hr). With the recent findings that clinical outcomes are related to CEPM AUC, further data are needed regarding the pharmacokinetics of cyclophosphamide and relevant metabolites in anephric children...
- Pharmacogenomic associations in ABCB1 and CYP3A5 with acute kidney injury and chronic kidney disease after myeloablative hematopoietic cell transplantationE L Woodahl
Department of Pharmacy, University of Washington, Seattle, WA 98195, USA
Pharmacogenomics J 8:248-55. 2008..Since no significant pharmacogenomic associations were observed, tailoring CNIs dosing based on these genotypes is unlikely to lower significantly the risk of renal injury following myeloablative HCT...
- Busulfan concentration and graft rejection in pediatric patients undergoing hematopoietic stem cell transplantationJ S McCune
Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Bone Marrow Transplant 30:167-73. 2002..It may be possible to improve the outcome of HSCT in pediatric patients receiving the BU/CY regimen through optimization of busulfan C(SS) and better definition of the contribution of activated cyclophosphamide metabolites to toxicity...
- Measured versus estimated glomerular filtration rate in the Calvert equation: influence on carboplatin dosingA Donahue
University of North Carolina, University of Washington, CB #7360, Beard Hall, Box 357630, Chapel Hill, NC 27599-7360 Seattle, WA 98195, USA
Cancer Chemother Pharmacol 47:373-9. 2001..The greater negative bias found for the latter three estimates of carboplatin clearance could result in underdosing of carboplatin...
- Evaluation of outcomes in converting from intravenous ondansetron to oral granisetron: an observational studyJ S McCune
School of Pharmacy, University of Washington, Seattle, WA, USA
Ann Pharmacother 35:14-20. 2001..Guideline revision and outcome documentation by the oncology pharmacists resulted in increased compliance with institution guidelines and a 40% cost savings...
- Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphanJ S McCune
University of Washington, Seattle, USA
J Clin Pharmacol 41:723-31. 2001..High inter- and intrasubject variability in DM:3MM and DM:DX were clearly demonstrated and limit the use of dextromethorphan to phenotype endogenous CYP3A4 and CYP2D6 activity...
- Patterns of blood product use among patients with myelodysplastic syndromeS D Ramsey
Research and Economic Assessment in Cancer and Healthcare REACH Group, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Vox Sang 102:331-7. 2012....
- Pharmacogenetics of intravenous and oral busulfan in hematopoietic cell transplant recipientsNissa Abbasi
University of Washington School of Pharmacy, Seattle, Washington, USA
J Clin Pharmacol 51:1429-38. 2011..Clearance of IV busulfan was not associated with GSTA1 (P = .21) or GSTM1 (P = .99). These data suggest that personalizing either IV or oral busulfan dosing cannot be simplified on the basis of GSTA1 or GSTM1 genotype...
- A phase I trial defining the maximum tolerated systemic exposure of topotecan in combination with Carboplatin and Etoposide in extensive stage small cell lung cancerHeidi H Gillenwater
The Multidisciplinary Thoracic Oncology Program, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer Invest 23:511-9. 2005..The purpose of this Phase I trial was to determine the maximally tolerated systemic exposure (MTSE) of topotecan in combination with carboplatin and etoposide...
- Pharmacological considerations of primary alkylatorsJeannine S McCune
Department of Clinical Research, Fred Hutchinson Cancer Rsearch Center, Seattle, Washington, USA
Cancer Treat Res 112:323-45. 2002
- Topotecan disposition in an anephric childLisa C Iacono
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Pediatr Hematol Oncol 26:596-600. 2004..The median topotecan lactone clearance was 15.5 L/h/m off hemodialysis and 18.7 L/h/m on hemodialysis. Topotecan clearance was minimally affected by hemodialysis and was similar to that observed in children without renal failure...
- A phase I/II study of mycophenolate mofetil in combination with cyclosporine for prophylaxis of acute graft-versus-host disease after myeloablative conditioning and allogeneic hematopoietic cell transplantationRichard A Nash
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Biol Blood Marrow Transplant 11:495-505. 2005..Although a significant improvement in the prevention of GVHD was not suggested, compared with CSP and MTX, MMF in combination with CSP could be considered in cases in which MTX is contraindicated...
- Gene expression profiling and breast cancer care: what are the potential benefits and policy implications?Nina Oestreicher
University of Washington, Seattle, Washington, USA
Genet Med 7:380-9. 2005..However, the outcomes associated with gene expression profiling are not clear, and guidelines for the appropriate use of genomic technologies have not been established...
- Fluconazole coadministration concurrent with cyclophosphamide conditioning may reduce regimen-related toxicity postmyeloablative hematopoietic cell transplantationArlo Upton
Clinical Research Division, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington, USA
Biol Blood Marrow Transplant 13:760-4. 2007..No difference in relapsed malignancy was apparent. These data support the hypothesis that fluconazole, when coadministered with CY, decreases CY-related toxicities by inhibiting cytochrome P450 2C9 metabolism...
- Real-time dose adjustment of cyclophosphamide in a preparative regimen for hematopoietic cell transplant: a Bayesian pharmacokinetic approachDavid H Salinger
Departments of Pharmacy, University of Washington, Seattle, Washington, USA
Clin Cancer Res 12:4888-98. 2006..To facilitate real-time dose adjustment, we developed open-source code within the statistical software R that incorporates individual data into a population pharmacokinetic model...
- Reduced incidence of acute and chronic graft-versus-host disease with the addition of thymoglobulin to a targeted busulfan/cyclophosphamide regimenH Joachim Deeg
Fred Hutchinson Cancer Research Center and University of Washington School of Medicine, Seattle, Washington 98109 1024, USA
Biol Blood Marrow Transplant 12:573-84. 2006....
- Pharmacodynamics of mycophenolate mofetil after nonmyeloablative conditioning and unrelated donor hematopoietic cell transplantationLuisa Giaccone
Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, D1 100, PO Box 19024, Seattle, WA 98109 1024, USA
Blood 106:4381-8. 2005..We conclude that increased MPA Css's predicted higher degrees of donor T-cell chimerism after unrelated donor nonmyeloablative HCT and suggest that targeting MPA Css's greater than 2.5 microg/mL could prevent graft rejection...
- Metabolism-based cyclophosphamide dosing for hematopoietic cell transplantGeorge B McDonald
Gastroenterology Hepatology Section, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Clin Pharmacol Ther 78:298-308. 2005..We conclude that metabolism-based dosing of cyclophosphamide is feasible and that a lower cyclophosphamide dose does not affect engraftment...
- Pharmacokinetics of oral mycophenolate mofetil in dog: bioavailability studies and the impact of antibiotic therapyMarilena Lupu
Biol Blood Marrow Transplant 12:1352-4. 2006
- The absolute bioavailability of oral vinorelbine in patients with solid tumorsRichard M Lush
Experimental Therapeutics Program, H Lee Moffitt Cancer Center and Research Institute, and the Department of Interdisciplinary Oncology, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
Cancer Chemother Pharmacol 56:578-84. 2005..Whole blood vinorelbine concentrations were measured using a sensitive LC/MS/MS method. The data from patients were excluded if they vomited within 3 h after the oral dose...
- Imatinib inhibition of fludarabine uptake in T-lymphocytesErica L Woodahl
Department of Pharmacy, University of Washington, Box 357630, Seattle, WA 98195, USA
Cancer Chemother Pharmacol 62:735-9. 2008..Imatinib is an inhibitor of human equilibrative transporters (hENTs), which are responsible for the intracellular uptake of fludarabine...
- A phase II multicenter study of visilizumab, humanized anti-CD3 antibody, to treat steroid-refractory acute graft-versus-host diseasePaul A Carpenter
Fred Hutchinson Cancer Research Center, Clinical Research Division, 1100 Fairview Ave N, Mailstop D5 290, Seattle, WA 98109, USA
Biol Blood Marrow Transplant 11:465-71. 2005..Survival at 180 days was 32% (95% confidence interval, 18%-46%). The administration of visilizumab as used in this study seems to be sufficiently safe and effective to warrant further assessment for treatment or prevention of GVHD...
- Rapid quantitation of cyclophosphamide metabolites in plasma by liquid chromatography-mass spectrometryThomas F Kalhorn
University of Washington Mass Spectrometry Center, Box 357610, Seattle, 98195, USA
J Chromatogr B Analyt Technol Biomed Life Sci 835:105-13. 2006..The development of this rapid analytical method makes it feasible to adjust the dose of cyclophosphamide based on the pharmacokinetic disposition of HCy and CEPM in hopes of decreasing nonrelapse mortality in cancer patients...
- A highly sensitive high-performance liquid chromatography-mass spectrometry method for quantification of fludarabine triphosphate in leukemic cellsThomas F Kalhorn
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Chromatogr B Analyt Technol Biomed Life Sci 820:243-50. 2005..The utility of the assay has been demonstrated by the analysis of F-ara-ATP in human leukemic cells after incubation with 9-beta-D-arabinosyl-2-fluoroadenine (F-ara-A) at clinically relevant concentrations...
- Current status of cetuximab for the treatment of patients with solid tumorsDeborah A Frieze
Seattle Cancer Care Alliance, WA, USA
Ann Pharmacother 40:241-50. 2006..To review the pharmacology, pharmacokinetics, clinical evidence, and safety, as well as the potential directions for use, of the epidermal growth factor receptor (EGFR) monoclonal antibody cetuximab...
- The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytesCeleste Lindley
Division of Pharmacotherapy, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Drug Metab Dispos 30:814-22. 2002..The impact of these effects on the efficacy and toxicity of CPA therapy warrants further investigation...
- The cost of adjuvant chemotherapy in patients with early-stage breast carcinomaNina Oestreicher
Division of Research, Kaiser Permanente, Oakland, California 94612, USA
Cancer 104:2054-62. 2005..The objective of the current study was to evaluate the direct medical cost of adjuvant chemotherapy in women with early-stage breast carcinoma...