text:
Wenger SYNERGY GA-7305-14 Carrying Case (Backpack) for 16" Notebook - GrayItem#: YYS1-3177519 | Model#: 27305140
Currently Out Of Stock!
Wenger SYNERGY GA-7305-14 Carrying Case (Backpack) Product Details
The Synergy 16" / 41 cm computer backpack is full of pockets and padding to protect all of your electronic accessories including up to a 16" / 41 cm widescreen laptop
Manufactured by: SwissGear
Warranty provided by: SwissGear
UPC No: 092837730540
Mfg Part No: 27305140
Box Size:
( Length:0, Width:0, Depth:0)
Shipping Weight: 3.6500 pound(s)
Click here for full warranty and support information
- SwissGear logos are registered trademarks of SwissGear. All others trademarks and copyrights mentioned herein are the property of their respective owners.


text:
Panasonic PT EZ570UL - LCD projector - 5000 lumens - WUXGA (1920 x 1200) - 16:10 - HD 1080p - no lens - LAN (PTEZ570UL)Item#: 9104827 | Model#: PTEZ570UL
- Price:
- $4,299.99
- Shipping:
- Temporarily out of stock. Order today and we'll deliver when available. (Details)
Panasonic PT EZ570UL LCD projector Product Details
The PT-EZ570UL features the highly durable optical engine with inorganic LCD panels and polarizers providing up to 10,000 hours of service without maintenance. The PT-EZ570UL offers low maintenance with the dust-resistant cabinet design and a washable Eco filter that needs no replacement for up to 12,000 hours. The PT-EZ570UL offers a long lamp replacement cycle of up to 4,000 hours. With the lamp power set to Auto, the intelligent lamp control system automatically adjusts the lamp output in accordance with the brightness of the projected image and reduces it by up to 70%. It also combines with color shift correction, which corrects the shift in the color balance that occurs when the lamp out put drops, resulting a reduction in power consumption while excellent color reproduction is maintained.
The PT-EZ570UL comes without a standard lens so you may choose the best lens for your particular application. Choose from a wide lineup of lenses projector including short-throw, long-throw zoom and fixed-throw lenses for rear projection use. The lenses attach and detach with one - touch ease.
Additional features of the PT-EZ570UL include a built-in 10-W speaker and a quiet design which keeps noise levels down to a quiet 31-dB which does not interrupt meetings or classes. Side-by-side and Picture-in-picture functions provide effective presentations and lectures. Two different image sources can be simultaneously displayed onto a single screen. By switching to picture-in-picture mode you can display a sub-window onto the main screen and position in any of the four corners.
Ease of filter and lamp replacement make the total cost of ownership low on the PT-EZ570UL. The filter is easily replaced from the side and the lamp from the top of the projector allowing for ease in maintenance.
Device Type: 3LCD projector - HD 1080p
Built-in Devices: Speaker
Networking: Ethernet
Data Link Protocol: Ethernet, Fast Ethernet
Localization: Taiwan, United States
Brightness: 5000 lumens
Contrast Ratio: 5000:1
Image Size: 40.2 in - 400 in
Throw Ratio: 1.7 - 2.8:1
Uniformity: 90 %
Resolution: WUXGA - WUXGA (1920 x 1200)
Native Aspect Ratio: 16:10
Video Bandwidth: 230 MHz
Display Format: 6,912,000 pixels (1920 x 1200) x 3
Color Support: 1.07 billion colors
Max Sync Rate (V x H): 100 Hz x 120 kHz
Lamp Type: UHM 330 Watt
Lamp Life Cycle: Up to 3000 hour(s) / up to 4000 hour(s) (economic mode)
Features: Picture in picture, Closed Caption, High-bandwidth Digital Content Protection System (HDCP), Daylight View Technology, Side-by-Side, 3LCD Technology, Deep Color, PJlink, Web Remote Control, Crestron RoomView, 16:10 aspect ratio support, e-mail alerts, Direct Power Off, Dust Resistant Cabinet, Eco Filter, Inorganic Materials, Intelligent Lamp Contro
Type: No lens
Video Input
TV System: NTSC, SECAM, PAL, PAL-N, PAL-M, NTSC 4.43, PAL 60
Analog Video Signal: RGB, S-Video, composite video, component video
Digital Video Standard: Digital Visual Interface (DVI), High-Definition Multimedia Interface (HDMI)
Video Interfaces: VGA, HDMI, S-Video, DVI
Video Modes: 1080/24p, 1080/60i, 480/60p, 720/60p, 1080/50i, 720/50p, 576/50p, 1080/50p, 1080/60p, 1080/30p, 480/60i, 1080/25p, 576/50i, 1035/60i, 1080/24sF, 1080/25sF, 1080/30sF
LAN and Wireless Image Transferring Protocols: Wired LAN
Video Output
Analog Video Signal: RGB
Type: Integrated
Sound Output Mode: Mono
Output Power / Channel: 10 Watt
Speakers: 1 x mixed channel - 1.5 in
Input Device
Type: External
Expansion / Connectivity
Interfaces: 1 x DVI-D input - 24+1 pin digital DVI ¦ 1 x HDMI input - 19 pin HDMI Type A ¦ 1 x RGB input - 15 pin HD D-Sub (HD-15) ¦ 1 x composite / component video / RGB input - BNC x 5 ¦ 1 x composite/component video input - RCA x 3 ¦ 1 x S-video input - 4 pin mini-DIN ¦ 1 x RGB output - 15 pin HD D-Sub (HD-15) ¦ 2 x audio line-in - mini-phone stereo 3.5 mm
Included Accessories: Cable cover, 2 x AAA batteries, wireless / wired remote control
Cables Included: 1 x VGA cable - 6 ft
Security Features: Security lock slot (cable lock sold separately), password protection, control panel lock, security bar
Compliant Standards: RoHS
Nominal Voltage: AC 120/230 V (50/60 Hz)
Power Consumption Operational: 490 Watt
Power Consumption Operational (Standby): 0.4 Watt
Software / System Requirements
Software Included: Drivers & Utilities, Logo Transfer Software, Multi Projector Monitoring & Control Software
Dimensions & Weight
Width: 19.3 in
Depth: 14.6 in
Height: 6.5 in
Weight: 21.16 lbs
Environmental Parameters
Min Operating Temperature: 32 °F
Max Operating Temperature: 104 °F
Humidity Range Operating: 20 - 80% (non-condensing)
Sound Emission: 37 dB
Sound Emission (Economic Mode): 31 dB
Related Items
Manufactured by: Panasonic
Warranty provided by: Panasonic
UPC No: 0885170083592
Mfg Part No: PTEZ570UL
Box Size:
( Length:0, Width:0, Depth:0)
Shipping Weight: 34.5000 pound(s)
Click here for full warranty and support information
- Panasonic logos are registered trademarks of Panasonic. All others trademarks and copyrights mentioned herein are the property of their respective owners.

subset: commoncrawl


text:
Ten young women will compete for the title of Miss Coon Rapids 2014 at the annual Miss Coon Rapids Scholarship Pageant which takes place Saturday, Nov. 23, 7 p.m., in the auditorium of Coon Rapids High School.
The candidates, their talent and their sponsor are:
• Makenzi Kovar, comedy monologue, Dino's Gyros.
• Kirsten Malcolm, dance, TGIF.
• Grace Christenson, vocal, Warners' Stellian.
• Paris Becker, lyrical dance, Coon Rapids North Star Lions Club.
• Tori Larson, motivational speech, Mississippi Dunes.
• Kayla Brown, skating routine, John Roberts Co.
• Kami Kaderlik, vocal, Pro Biz Sports.
• Bailey Reese, violin, Goulds Jewelry.
• Kami Patrin, monologue, Coon Rapids Fire Department.
• Amanda Moder, dance, Around Town.
In tandem with the Miss Coon Rapids Pageant tomorrow, the pageant committee is also sponsoring the annual Miss Coon Rapids Outstanding Teen Pageant, whose winner also goes on to state competition.
The five candidates and their talent are:
• Mia Pagnac, cello.
• Kallie Jo Ascheman, vocal.
• Annika Kovar, gymnastics routine.
• Leah Mau, vocal.
• Breanna Smith, ribbon dance.
There is a new director of the pageants this year – Theresa Leggate.
Active as a volunteer on the pageant committee for many years, Leggate takes the helm from Diane Buszta, who had been pageant director for decades.
Buszta is now the state director for the Miss Minnesota Outstanding Teen Pageant.
This will be the second year that the pageant has taken place in November, rather than during Coon Rapids Snowflake Days in early February as in the past.
The switch in dates was made primarily to allow the new Miss Coon Rapids more time to prepare for the Miss Minnesota Scholarship Pageant, which takes place each year in June. The Miss Minnesota winner advances to the Miss America Scholarship Pageant.
But the pageant will be back at Coon Rapids High School this year; it was at Anoka-Ramsey Community College a year ago.
There will be a dress rehearsal this evening (Friday, Nov. 22) at the high school, then the contestants are back at the high school tomorrow morning (Nov. 23) at 8 a.m. for the judges interview followed by a run-through of the pageant program.
The Miss Coon Rapids and Miss Coon Rapids Outstanding Teen pageants are "open" pageants.
Candidates for Miss Coon Rapids must be between the ages of 17 and 24 and live, work or go to school within the state to participate. Proof of residency or college enrollment is required.
There are five competition areas in the Miss Coon Rapids Pageant – talent worth 35 percent of the total score, judges interview 25 percent, evening wear 20 percent, lifestyle and fitness in a swimsuit 15 percent and on-stage question 5 percent.
As part of the 10-minute press conference style interview with the pageant judges, contestants present a platform on an issue or program of their own choosing.
Eligibility for the Miss Coon Rapids Outstanding Teen Pageant is a young woman between the ages of 13 and 17 living in or going to school in Minnesota.
Contestants are judged in six areas – private interview 30 percent of the score, scholastic achievement 5 percent, on-stage question, 5 percent, lifestyle and fitness 10 percent, talent 35 percent and personal appearance and poise in evening wear 15 percent.
Miss Coon Rapids Emily Kallis and 2013 Miss Coon Rapids Outstanding Teen Kathryn Kueppers will relinquish their titles Nov. 23.
Both finished third runner-up in their respective state competitions earlier this year.
Reserved tickets for the pageant are $15 for main floor seating in the auditorium and $9 for balcony seating.
To purchase tickets call John Leggate at 763-757-4971 or email [email protected].
Peter Bodley is at [email protected]


text:
Open Splenectomy
Laparoscopic Splenectomy
Quirón has an internationally prestigious medical staff, the largest in the sector, and is also the principal hospital network in terms of patient numbers and care facility area. The group administers 38 healthcare centers, more than 2,864 hospital beds and 7,500 associate doctors.
Spleen Removal Surgery
upon request
HM Hospitales is a hospital group with six private hospitals in Madrid: three general hospitals, a cardiovascular hospital, an oncological center and a women's health hospital.
Xanit Hospital Internacional is a modern private hospital located in the suburbs of Malaga, Spain. The hospital is modern (opened in 2005), and the staff include over 200 specialists in all medical specialties.
idcsalud Hospital General de Catalunya provides medical services in over 25 specialties, being one of the most technologically advanced hospitals in Europe, with an excellent medical care capacity to carry out complex surgeries and medical conditions.
An ISO certified modern private hospital, which was opened in 2006, and is part of the Quirón Hospital Group. This tertiary care hospital 400 has certified physicians from all medical specialties capable of treating the most complicated medical cases.
Head of Division of General and Digestive Surgery
Head of Division of Thoracic Surgery
Hospitales San Roque has been consolidated over time in the health sector, with a strong bet for the future with the increase of its facilities and installations and the most advanced technologies designed to give the best health care and welfare to the patient.
Medimar International Hospital is a tetriatry care hospital with 200 physicians, 50 resident and 150 affiliated, providing healthcare services to the residents of Alicante, as well as to over 25,000 foreign patients a year.
The Ruber International Hospital is designed as a "whole hospital". thus achieving maximum efficiency in the organization and development of the various medical, welfare, educational and research activities.
Sant Joan de Déu-Barcelona Children's Hospital is one of the leading medical centers in Europe for childhood and adolescence medicine and offers a comprehensive and multidisciplinary approach to health care from birth through 21 years of age.
A modern (opened in 2007), general, private hospital located in Madrid, part of the NISA group of hospitals. The international patients department can assist patients with accomodation and trasportation, and can communicate in English as well as in Spanish.
This information is intended for general information only and should not be considered as medical advice on the part of Health-Tourism.com. Any decision on medical treatments, after-care or recovery should be done solely upon proper consultation and advice of a qualified physician.
What is Spleen Removal Surgery?
Spleen removal surgery, known as splenectomy, is a surgical procedure in which a diseased or damaged spleen is partially or completely removed.
How is Splenectomy Performed?
Spleen removal surgery can be performed by an open surgery or by a laparoscopic method. The surgery may be done to completely remove the spleen that is enlarged or ruptured, or the spleen may also be partially removed.
Open-complete splenectomy to remove an enlarged spleen
Copyright © 2008 - 2017 Health-Tourism.com, All Rights Reserved


text:
NewswireToday - /newswire/ -
Hazlet, NJ, United States, 2011/08/25 - Comrise Technology, Inc., a leading minority-owned IT staffing company was recently recognized by Staffing Industry Analysts on its 2011 Diversity Staffing Firms list - Comrise.com / StaffingIndustry.com.
New Jersey-based Comrise Technology, Inc., a leading minority-owned IT staffing company specializing in direct and contract staff augmentation, recruitment process outsourcing (RPO), payroll services, vendor management, and managed IT solutions, was recently recognized by Staffing Industry Analysts on its 2011 Diversity Staffing Firms list.
With headquarters and branch offices throughout the U.S. and China, Comrise has built a global reputation by providing top-caliber consultants and professional services to a wide range of industries, including IT, Telecommunications, Financial Services, Pharmaceuticals, Clinical Research, and Electronics. Comrise works closely with clients in order to deliver world-class professional consultants who will streamline their business operations.
Comrise General Manager, Thomas Liou, said: We are honored to appear alongside other staffing companies who share our commitment to diversity. We believe it is this commitment that sets Comrise apart and allows us to offer the highest levels of customer service to our clients around the world. Comrise continues to seek new opportunities to work with companies that value our minority status in forming many mutually beneficial business relationships. In fact, Comrise is also committed to passing on the same benefits to its own network of suppliers through Comrise Technologys Supplier Diversity Program.
About Staffing Industry Analysts
Staffing Industry Analysts (staffingindustry.com) is the global advisor on contingent work. Known for its independent and objective insights, the companys proprietary research, award-winning content, data, support tools, publications, and executive conferences provide a competitive edge to decision-makers who supply and buy temporary staffing.
About Comrise
Established in 1984, Comrise Technology (comrise.com) is a minority-owned and minority-managed IT services company with headquarters in the U.S. and China. For nearly 30 years, Comrise Technology has been a leading provider of direct and contract staff augmentation services, recruitment process outsourcing (RPO), payroll services, vendor management, and managed IT solutions. With headquarters in the U.S. and China, Comrise provides local talent and resources on a global scale.
Written by / Agency / Source: Comrise Technology, Inc.
Availability: All Regions (Including Int'l)
Traffic Booster: [/] Quick Newswire Today Visibility Checker
Distribution / Indexing: [+]


text:
The Week Ahead: The Rajasthan International Folk Festival
Highlights of news and events related to India this week:
Monday, Oct. 10: Over 20 U.S. universities will be touring India accompanied by Indian officials to meet with Indian partners and explore opportunities to cooperate further. The trade mission will last for five days.
Tuesday, Oct. 11: Rashtriya Janata Dal chief Lalu Prasad Yadav is expected to begin a march in Patna to urge Bihar chief minister Nitish Kumar to investigate corruption scams in his state.
Wednesday, Oct. 12: India with 19 other nations is likely to participate in an exercise to test the operational capacity of the Indian Ocean tsunami alert system.
The Rajasthan International Folk Festival, which brings together 250 musicians and performing artists, starts in Jodhpur today and runs until Oct. 16.
The India-Africa Business Summit, aimed at tracking the progress made in bilateral trade, begins today.
Software giant Infosys Ltd. is set to announce their financial results for the July-September quarter today.
Thursday, Oct. 13: Bhutan braces for a royal wedding as King Jigme Khesar Namgyel Wangchuck is set to marry his fiancé Jetsun Pema today.
The Hero Indian Open Golf, a three-day tournament is set to begin in New Delhi today.
Friday, Oct. 14: The India-England One Day International Series begins in Hyderabad.
"Mod," a movie starring Ayesha Takia and Rannvijay Singh is due for release today.


text:
05-21-2008 #1Starlight Guest
PC Gamer Hints Diablo 3 on August 2008 Edition?
Another fan-fueled Diablo Rumor Mill has propelled out in full swing after PC Gamer's July edition wrapped up with the following text:
"NEXT MONTH: Have you ever had a secret that you're just dying to blurt out, but you can't for another month, and the stress of holding it in makes you want to do the pee-pee dance? That's what the PC Gamer staff is doing right now, because the August issue will be chock-full of exclusives, including a top-secret cover story so huge we had to go to [CENSORED] to get it. Just 30 days more ..."
Here are a few thoughts to ponder on this brainstorming puzzle PC Gamer unleashed:
- PC Gamer was probably among the Gaming press Magazines who visited Blizzard Entertainment early on May, a few weeks ago.
- If you remember, PC Gamer knew about the Starcraft II announcement last May 2007. Blizzard Entertainment made the announcement at the Blizzard Worldwide Invitationals (WWI) at Seoul, South Korea.
- PC Gamer can't talk about it for the next 30 days ... the 2008 Blizzard Worldwide Invitationals at Paris, France takes place on June 28-29.
- June 29 is the date Diablo II shipped on USA (2000) and the same date the expansion Lord of Destruction shipped on Europe a year later (2001).
- Notice how PC Gamer replaces a swearing with [CENSORED]? Could this be a clue as to what the game they refer to? Because CENSORED really sounds like HELL ... as in ... Diablo?
More PlayStation 3 News...


text:
Mustchin made his Scotland debut on the summer tour to Argentina last year and has been an important member of the Edinburgh team for the past 18 months.
His absence reduces Hadden's lock options although he still has first-choice pairing Jim Hamilton and Nathan Hines ready for action with some able deputies to call on.
These may include Jason White and Simon Taylor, who are both back-rowers by trade, but can play in the engine room if required.


text:
Food Lion Deals 8/24: Chicken leg quarters, Tyson chicken, pork loin
Posted August 24, 2016
Food Lion has some great deals starting Wednesday, 8/24 including chicken leg quarters, Tyson chicken, pork loin, ground chuck, top sirloin steaks, flounder, Oikos yogurt, Coke, Skippy peanut butter and more!
These deals are valid Wednesday, August 24 – Tuesday, August 30, 2016
Box Tops Bonus: Buy any 5 General Mills or Annie's Box Tops for Education products and get 20 bonus Box Tops when you use your MVP card. Offer valid 8/24 – 8/30/16.
Green peppers, .69 each
Russet potatoes, .79/lb
Mangoes, .89 each
Red onions, .99/lb
Red vine cluster tomatoes, $1.29/lb
Food Lion baby carrots, 16 oz, $1.29
Red seedless grapes, $1.49/lb
Yellow or white nectarines, $1.49/lb
Fresh Express salad blends, 6 – 11 oz package, $2
Gala Apples, 3 lb bag, $3.29
Food Lion chicken leg quarters, .49/lb (sold in 10 lb bag)
Nature's Place whole chicken, $1.59/lb
Boneless pork loin, $1.79/lb.
Nature's Place boneless pork loin, $2.49/lb
80% lean fresh ground chuck, $2.99/lb
Inland Market Tilapia fillets, 10 oz, $2.99
Boneless center cup pork chops, $3.49/lb
Boneless top sirloin steaks, $3.99/lb.
Sirloin fillet, $4.89/lb
Food Lion Arrowtooth flouder, 32 oz, frozen, $4.99
Food Lion raw shrimp, 26 – 30 count, frozen, $5.99
Johnsonville breakfast sausage patties or links, 9 – 12 oz select $2.99
Food Lion cooked ham or American cheese at the deli, $2.99/lb
Ball Park meat franks, 14 - 15 oz, 2 for $4 - $1/2 coupon from in-store kiosk = $1.50 each
Oikos Greek yogurt, 5.3 oz, .88 - .75/4 from 8/14 SS
Taste of Inspirations, 10 oz, BOGO for $1.49 each
Food Lion natural cheese slices, 8 oz, $2.00
Almond Breeze Almond Milk, 64 oz., $2.50 - .50/1 coupon from 7/24 SS
Taste of Inspirations fresh salsa, 16 oz, $2.50
Edy's ice cream, 48 oz, $2.50
Tyson frozen breaded chicken, select, family pack, 25.5 – 32 oz, $3.99 (photo shows chicken nuggets) - $1 coupons fro 8/14 SS or 7/24 RP =$2.99
Freschetta pizza, select, $3.99
Misc. Grocery
Betty Crocker Hamburger or Chicken Helper, 4 – 12 oz select, $1 - .75/3 coupon from 7/10 SS and possibly 8/28 SS
Hunt's Snack Pack, 5 for $5 - $1/5 coupon from in-store coupon kiosk AND .45/3 coupon from 7/31 SS
Juicy Juice juice, 64 oz, $2.50 - .55/1 coupon from 8/21 or 5/22 SS
Gatorade, 32 oz, .89
Betty Crocker brownie and cake mix, $1.00
7UP or Canada Dry products, 2 ltr, $1.00
Skippy peanut butter, 16 – 16.3 oz, $2.50 AND Buy 2 Get 1 Free - .50/1 coupon from 7/31 SS = 3 for 4 (after 2 coupons)
Doritos, 9.5 – 11.5 oz, BOGO for $2.15 each
Food Lion sodas, 12 pack cans, $2.39
Coke products, 6 count bottles, 4 for $10
Lay's potato chips, 2 for $5
Maxwell House coffee, 22 – 30.6 oz, $5.99
Garnier shampoo or conditioner, 13 oz, select, 2 for $5 - $3/2 coupon possibly in 8/28 RP insert = 2 for $2
Scott paper towels 8 mega rolls or bath tissue, 6 – 12 rolls, $4.99
Coupons: .65/1 paper towels coupon from 7/31 SS, .75 bath tissue coupon (8 or more rolls) from 7/31 SS
Arm & Hammer laundry detergent, 122.5 – 150 oz, $5.99
Food Lion Coupon Basics
Food Lion does not double coupons.
They have no limits on number of total number of coupons they will take, unless specified in the ad. You may only use a maximum of 10 (ten) coupons for the same item per customer. This includes coupons that are downloaded onto your personal MVP Card.
BOGO items ring up at half price so if you only buy 1, it rings at half price. You can use a coupon on each BOGO sale item.
You cannot use Food Lion store coupons and manufacturer's coupons on the same item. "Stacking" coupons like that is not allowed per the Food Lion coupon policy.
You can see their entire coupon policy on their website HERE.
The ad indicates that prices are valid for stores in these cities: Apex, Bunn, Cary, Clayton, Franklinton, Fuquay-Varina, Garner, Holly Springs, Knightdale, Louisburg, Morrisville, Raleigh, Rolesville, Wake Forest, Wendell, Youngsville, Zebulon. If you do not live in one of these cities, your ad may be different and you can check for any differences on FoodLion.com.
E-Coupons: You can now load RedPlum.com manufacturer's coupons to your Food Lion MVP card and when they scan your card at the register and you buy the qualifying items, the discount will come off automatically. I spoke with corporate and they confirmed that these are manufacturer's coupons and not to be combined with paper manufacturer's from the newspaper and other sources. She said their policy is only 1 coupon per product. No e-coupons will double. Click HERE for more information.
Quality Guarantee: Food Lion offers a double money back quality guarantee on all Food Lion store brands.
This post may contain affiliate links and I appreciate your using them!


text:
Conference Scorecard: ACC up, Big 12 down
Miami's 21-20 win against Oklahoma helped get the ACC out of last place in our BCS nonconference standings, while the Sooners' struggled continued a rough trend for the Big 12, which went 0-3 against BCS conference opponents.
The Big 12 doesn't play another nonconference game against a BCS league opponent, so their 4-7 record is now final until bowl season. When you consider that the Big 12 went 3-0 in such games on the opening weekend, that means they're 1-7 since, the lone win coming from Kansas against Duke.
And if you look at wins against ranked opponents as opposed to losses as ranked teams, the Big 12 is the worst of the BCS leagues, with just one win against a ranked opponent (Oklahoma State beat Georgia in its opener) with four losses as ranked teams. That minus-3 differential stands out -- the ACC, Pac-10 and Big East are plus-1, while the SEC and Big 10 are both even.
The SEC remains the BCS league to beat, as the only conference with a winning record against other BCS league opponents. The Big East now has matched the Pac-10 for the second-best mark at 6-6, thanks to West Virginia's win against Colorado. And the Big 12 doesn't play another nonconference game against a BCS league opponent, so their 4-7 record is now final until bowl season.
League Nonconf Vs. BCS
Big East 23-7 (.766) 6-6
Pac-10 19-9 (.679) 6-6
Big Ten 25-9 (.735) 5-7
Big 12 34-13 (.723) 4-7
It's worth noting that Notre Dame is 3-1 now against BCS opponents. The inter-conference games grow less frequent in the second half of the season -- there are just 13 more the rest of the year -- the ACC still has seven, and the Big East and SEC have four left, but the Pac-10 has just three and the Big 10 two.
There's just one BCS vs. BCS game in each of the next three weeks -- Indiana at Virginia, then Notre Dame-USC and Notre Dame-Boston College. The Georgia Tech-Vanderbilt game on Halloween is the only other BCS showdown (except for Notre Dame games) until Thanksgiving weekend, when there are five such games to crown a regular-season champ to the conference battles we've been tracking.
Our BCS buster update shows no wins this week against BCS opponents -- the Mountain West is now 5-9, Conference USA is 3-13, the Western Athletic is 2-9, the Mid-American is 3-21 and the Sun Belt is 2-15. As a whole, the BCS outsiders are 15-67 against BCS competition, winning 18.3 percent of the time.


text: From the popular and award-winning Law & Order franchise comes Law & Order: Special Victims Unit. This hard-hitting and emotional series chronicles the exciting cases of the NYPDs Special Victims Unit as they try to crack the citys most heinous crimes. Featuring a celebrated cast that includes Christopher Meloni (TVs Oz), Mariska Hargitay (TVs ER), Dann Florek (The Flintstones), Richard Belzer (TVs Homicide: Life on the Street), Dean Winters (TVs Oz) and Michelle Hurd (Random Hearts).Includes Episodes: 1. Payback, 2. A Single Life, 3. Or Just Look Like One, 4. Hysteria, 5. Wanderlust, 6. Sophomore Jimx, 7. Uncivilised, 8. Stalked, 9. Stocks & Bondage, 10. Closure, 11. Bad Blood, 12. Russian Love Poem, 13. Disrobed, 14. Limitations, 15. Entitled, 16. The Third Guy, 17. Misleader, 18. Chat Room, 19. Contact, 20. Remorse, 21. Nocturne & 22. Slaves.Special Features:Special Victims Unit: The Beginning Dann Florek Walk ThroughCheck stock and price


text:
He Doesn't Know If You've Been Bad or Good
Santa is at the mall. He poses with children. I have a child. She looks cute in red sweaters. Her parents are ambivalent about Santa. This is kind of where we are, right now?
1. Santa was a lot of fun, and it did not actually bum me out a lot when I found out, and I was damn near twenty.
2. Some kids do not get Christmas presents from Santa because their parents do not have any money, and then they go to school and other kids have presents from Santa.
3. A bunch of kids are Jewish. A bunch of kids are Muslim. Those kids generally still manage to have imaginations and the spirit of youthful vigor in their hearts, and are not immediately taken to the Lowell mills at the age of two.
4. If you decide NOT to do Santa, you are kind of just switching the burden of deception onto your kids, because people will go crazy on them if they do not play along with the others, which sometimes does involve flat-out lying, even though Santa may not be a "lie" per se.
5. WHAT is this Elf on the Shelf thing? It seems to have happened overnight, but now everyone seems to do it? Parallels include bikini waxing and casting Jessica Chastain, not that either of those things are necessarily un-good?
6. There's an internet now, so good luck with everything. It's not like olden times, when you had to write insipid letters to newspapers and get smarmy answers. Google: "santa real?"
7. How is this different from religion? I mean in terms of "oh, we don't do that, but you do you." That seems to work fine for religion, but gets super-controversial with Santa. Can you just say "what do YOU think?" incessantly?
8. A woman in a comment section once said: "I am not busting my ass working two jobs to afford presents and then giving credit to a made-up white man." Speaking of, do you just do one gift from Santa, or all of them from Santa?
9. If, in general, the entirety of your spiritual conviction is watching "The Muppet Christmas Carol" six times a year and then smiling beatifically at everyone you meet for the next week, will it all just take care of itself?
10. It must be really shitty for specifically non-Christian teachers to have to play along every year, especially when that part of the year begins at the end of October now, and especially if you teach kids at the cusp age for "waaaaaaait a minute," and especially if you're a little hungover and just want to explain about didgeridoos or whatever your lesson plan was. And then maybe you accidentally end up on Fox News with a grinch hat superimposed on your aching head?
11. What happens if it becomes a series of escalating one-ups? "Oh, Jimmy's parents leave cookies for Santa and then they find crumbs the next day!" "Jimmy's parents showed him reindeer hoofprints on their roof!" "Jimmy got a six-page single-spaced letter back from Santa telling him why he was the best little boy in town!" "Jimmy gave me a funny cigarette and now you have to take time away from Google Image searching Sean Bean to attend a meeting."
12. Eh, whatever, we'll probably just do it.


text:
Happy day to all you lefties. You may not have known until you picked up this paper and tried to open it, that today is International Left-Handers Day. What a surprise!
For what it's worth, this paper is for you!
Today has been selected by the powers that be, the day you and your "special gift" are recognized. Today's Southwest Times is designed just so you can have a taste of functioning in a left-handed society and for your counterparts to recognize the obstacles you have to hurdle to function in a right-handed society.
We hope you enjoy this paper, and make sure all your other "southpaw" friends get a copy of the Times for their enjoyment.
The editorial staff really enjoyed putting this edition together, and I know the advertising staff had a good time selling it.
Today's edition is dedicated to a very special person, my own mother, Frances Pettigrew. Even though she has been gone for some 33 years, I know she knows I do this little thing every year just as a remembrance of her.
While I was working in Iowa, I became aware of this day and lobbied hard for a chance to do a left-handed paper. My boss finally gave in, and when it was printed, it was so popular, we decided to enter it in the Better Newspaper Contest held yearly by the Iowa Newspaper Association. To my shock, it won first place!
Just after this contest, one of my friends from Burlington, Iowa came in one day and handed me a book all about left-handers. She said she had purchased it a few weeks before, but just hadn't gotten the opportunity to give it to me. I couldn't believe it, but the day she gave me the book was the anniversary of my mother's death. I'd been pretty sad that day until then, but after that, I was elated, as I knew her giving me this book on this day meant my mother was saying thank you for the thought.
You see the main reason I want to do this paper yearly is because of a story my mother used to tell about how embarrassed she was in school as a little girl when the teachers would tie her hand behind her back to try and make her write with her right hand.
Needless to say, that experience marked her and she always seemed to think less of herself and her accomplishments than she should. Believe me, all that I've ever heard about left-handed people being talented and creative was true about her. She was the most talented seamstress I've ever seen, making many beautiful items, including some of the most beautiful draperies you've ever seen for the church's sanctuary and our house.
Sewing was just one of her many talents, but, as I said, she never got over the embarrassment of the classroom.
So, Mom, this paper is in recognition of you, your many talents and your beautiful soul.
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text:
garlic mustard – Alliaria petiolata
- Appearance
- Alliaria petiolata is an herbaceous, biennial forb. First year plants are basal rosettes which bolt and flower in the second year. Plants can be easily recognized by a garlic odor that is present when any part of the plant is crushed.
- Foliage
- Foliage on first year rosettes is green, heart shaped, 1-6 in. (2.5-15.2 cm) long leaves. Foliage becomes more triangular and strongly toothed as the plant matures.
- Flowers
- Second year plants produce a 1-4 ft. (0.3-1.2 m) tall flowering stalk. Each flower has four small, white petals in the early spring.
- Fruit
- Mature seeds are shiny black and produced in erect, slender green pods which turn pale brown when mature.
- Ecological Threat
- Alliaria petiolata is an aggressive invader of wooded areas throughout the eastern and middle United States. A high shade tolerance allows this plant to invade high quality, mature woodlands, where it can form dense stands. These stands not only shade out native understory flora but also produce allelopathic compounds that inhibit seed germination of other species. Alliaria petiolata is native to Europe and was first introduced during the 1800s for medicinal and culinary purposes.
Sites reporting this species
- Appalachian Scenic Trail
- Skamania County, WA
- Clackamas
- Westfield River, Massachusetts
- Champlain Valley of Vermont
- iMap Invasives - New York
- Vermont Inst. of Nat. Sci.
- Cleveland Elementary
- Cuyahoga Valley National Park
- SuAsCo, Massachusetts
- Southern Indiana
- Saint-Gaudens National Historic Site
- Marsh-Billings-Rockefeller NHP


text:
Learning to Tie
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pa dave
Senior Member
Join Date: Feb 2012
Location: South Eastern Pennsylvania
Posts: 233
Re: Learning to Tie
I started out with a kit, and I agree with the above...you can do better piecing a kit together. None the less, I used that kit for some time and I still use many of the tools. Look at what is included in the average kit, then watch a number of videos on tying to see if any of them are rarely used, or if there are ones that are used regularly that aren't in the average kit. The big disappointment was the tying materials, which where scant and very poor quality. If you live close to a fly shop and have easy access to supplies, only buy what you need for a particular pattern or three that you want to tie, and go back for more when needed. If you have to drive an hour, or have to rely on internet suppliers, you may want to do a bit of research to make sure you don't end up ordering again in a week. Of course, with the price of gas and the low weight of the materials, shipping could well be less that the gas needed to go to the shop. Personally, I like to see them first and you can only do that at the fly shop, and I like to use my local shop as much as possible...or I did before they closed up.
There are great websites for fly recipes and YouTube videos are great. One I'd recommend searching for is David Cammiss. He has a number of lessons done for various skill levels. Books can be really frustrating because you see what each step looks like, but seeing it done is much easier to follow.
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text:
There's Only ONE GUY Born in the 1800s Left….In the World!
The last man alive who was born in the 1800s lives in Kyoto, Japan. Jiroemon Kimura is 116-years-old and I imagine you, like I, cannot say his name, so let's just call him, "Bob"….
Bob was born back in 1897 and there's no other guy left who was born before 1900. A pretty cool title. He's hoping it lasts a while.
Bob is what is known as a Supercentenarian, someone who has lived past their 110th birthday. Can you say, Supercentenarian? Sure you can.
Now, insofar as women are concerned, there are 10 of THEM left who were born in the 1800s. That means if all of these women sign onto the website I'm creating called "1800swomenwhowanttogetbusywithasupercentenarian.com," Bob will be a very lucky man…or very unlucky, depending on how strong his old ticker is!
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text:
A relação entre a proporção de protestantes e IDH nos estados do Brasil : uma abordagem ecológica
There is evidence that behavioral and lifestyle changes, encouraged by the Protestant churches in Brazil (especially Pentecostals and Neo-Pentecostals), are positively associated with variables such as health and income, which are, in their turn, considered into the Human Development Index (HDI) In this sense, the present study, is a preliminary and exploratory exercise in ecological level, on the relationship between the proportion of Protestants and the HDI for each state (UF) in Brazil. Through a regression model, we observed positive relationship between HDI and the proportion of Protestants. However, in the case of ecological relationships at the state level, it is premature to say that also occur in the cities, in neighborhoods and communities. More importantly, it is not possible to extrapolate this relationship to individuals. In view of these findings, one of the directions that we intend to advance this research is the incorporation of other scales of data analysis.
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|Date of creation:
|May 2011
|Contact details of provider:
| Postal: Cedeplar-FACE-UFMG Av. Antonio Carlos, 6627 Belo Horizonte, MG 31270-901 Brazil
Phone: 55-31-3409-7100
Fax: +55 31 3201-3657
Web page: http://www.cedeplar.ufmg.br
More information through EDIRC
|Order Information:
| Postal: Cedeplar-FACE-UFMG Av. Antonio Carlos, 6627 Belo Horizonte, MG 31270-901 Brazil
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text:
Don't miss out on a lower price on this hotel
Get an overview of this hotelSuburban hotel with full-service spa and restaurant
Collecting Nectar Points
Special Offer: Book by 2 August 2017 and collect double Nectar points!
Simply enter your Nectar card number when you check out. Your points will be credited 35 days after you return from your trip.
*Terms and conditions apply.
Popular property highlights
Situated in a shopping district, this spa hotel is 0.6 mi (0.9 km) from metrocentre and within 6 mi (10 km) of Tyne Bridge and St. James' Park. BALTIC Centre for Contemporary Art and Gateshead Millennium Bridge are also within 6 mi (10 km).
Hotel Features
This hotel features a full-service spa, a restaurant, and an indoor pool. Free WiFi in public areas and free self parking are also provided. Additionally, a fitness center, a bar/lounge, and a coffee shop/café are onsite.
Room Amenities
All 150 rooms offer comforts like Egyptian cotton sheets and pillow menus, plus 24-hour room service and flat-screen TVs with satellite channels. Other amenities available to guests include WiFi, coffee makers, and down comforters.Information missing or incorrect? Tell us!Opens in a new window
Newcastle Gateshead Marriott Hotel Metrocentre
Hotel Amenities
Hotel Amenities
In addition to a full-service spa, Newcastle Gateshead Marriott Hotel Metrocentre features an indoor pool and a spa tub. The hotel offers a restaurant and a coffee shop/café. A bar/lounge is on site where guests can unwind with a drink. A computer station is located on site and wireless Internet access is complimentary.
This 4-star property offers access to a business center and meeting rooms. Event facilities measuring 5640 square feet (524 square meters) include conference space. This business-friendly hotel also offers a fitness center, a sauna, and spa services. Onsite self parking is complimentary.
Newcastle Gateshead Marriott Hotel Metrocentre has designated areas for smoking.
- Express check-out
- Safe-deposit box at front desk
- ATM/banking
- Number of floors - 5
- 24-hour front desk
- Breakfast available (surcharge)
- Free newspapers in lobby
- Conference space
- Express check-in
- Fitness facilities
- Full-service spa
- Designated smoking areas (fines apply)
- Computer station
- Free WiFi
- Luggage storage
- Business center
- Dry cleaning/laundry service
- Total number of rooms - 150
- Meeting rooms 9
- Restaurant
- Conference space size (meters) - 524
- Number of meeting rooms - 8
- Year Built 1989
- Conference space size (feet) - 5640
- Pool sun loungers
- Free self parking
- Sauna
- Spa tub
- Indoor pool
- Bar/lounge
- Coffee shop or café
- Wedding services
- Elevator/lift
- Designated smoking areas
- Laundry facilities
- Multilingual staff
- Garden
- Number of buildings/towers - 1
- Spa services on site
- Steam room
Family Friendly Amenities
- Family Hotel
- Indoor pool
- Free Wi-Fi
- Laundry facilities
Available in all rooms:
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Premium TV channels
- Pay movies
- Premium bedding
- Hair dryer
- Air conditioning
- In-room climate control (air conditioning)
- Coffee/tea maker
- Daily housekeeping
- Private bathroom
- Free toiletries
- Iron/ironing board
- Desk
- Hypo-allergenic bedding available
- In-room safe (laptop compatible)
- Satellite TV service
- Flat-panel TV
- WiFi (surcharge)
- Shower/tub combination
- Room service (24 hours)
- Connecting/adjoining rooms available
- Rollaway/extra beds (surcharge)
- Blackout drapes/curtains
- Down comforter
- Egyptian-cotton sheets
- Pillow menu
Where to Eat
Full breakfasts are available for a surcharge and are served each morning.
The Rare Grill Restaurant - This restaurant serves breakfast and dinner. Guests can enjoy drinks at the bar. A children's menu is available.
Chats Bar - This bar specializes in British cuisine and serves lunch, dinner, and light fare.
24-hour room service is available.
Nearby Things to Do
An indoor pool and a spa tub are on site. Other recreational amenities include a sauna and a fitness center.
Children under 16 years old are not allowed in the swimming pool, health club, fitness facility, or spa tub without adult supervision.
Spa Services
The Comfort Zone has 2 treatment rooms. Services include massages, facials, body wraps, and body scrubs. The spa is equipped with a sauna and a steam room.
- Steam room in spa
- Number of treatment rooms 2
- Manicures and pedicures
- Body wraps
- Body scrubs
- Sauna in spa
- Massages
- Body treatments
- Facial treatments
If you have requests for specific accessibility needs, please note them at check-out when you book your room.
- Accessible bathroom
- In-room accessibility
Hotel Policies
Check-in time ends at midnight
Check-in time starts at 3 PM
Check-out time is noon
Payment types
Children and extra beds
- Children are welcome.
- Kids stay free! Up to 2 children 16 years old and younger stay free when using existing bedding.
- Rollaway/extra beds are available for GBP 15.00 per stay.
- Cribs (infant beds) are not available.
- Pets not allowed (service animals welcome)
You need to know
Extra-person charges may apply and vary depending on property policy.
Optional extras
- Fee for full breakfast: GBP 15.95 per person (approximately)
- Fee for in-room wireless Internet: GBP 8.00 per day (rates may vary)
- Rollaway bed fee: GBP 15.00 per stay
Hotel Name
- Marriott Hotel Gateshead Newcastle
- Marriott Hotel Metrocentre
- Metrocentre Marriott Hotel
- Newcastle Gateshead Marriott Hotel Metrocentre
- Newcastle Gateshead Marriott Metrocentre
- Newcastle Marriott Hotel Metrocentre
- Newcastle Marriott Metrocentre
- Marriott Gateshead
We should mention
Reservations are required for massage services and spa treatments. Reservations can be made by contacting the hotel prior to arrival, using the contact information on the booking confirmation. Up to 2 children 16 years old and younger stay free when occupying the parent or guardian's room, using existing bedding. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


text:
|Publication number
|Publication type
|Application number
|Publication date
|Nov 13, 2007
|Filing date
|Aug 5, 2004
|Priority date
|Jun 4, 1998
|Fee status
|Also published as
|Publication number
|David Utley, John W Gaiser, Rachel Croft
|Original Assignee
|Curon Medical, Inc.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (106), Non-Patent Citations (10), Referenced by (29), Classifications (15), Legal Events (5)
|External Links: USPTO, USPTO Assignment, Espacenet
This application is a divisional of U.S. patent application Ser. No. 09/994,375, filed Nov. 26, 2001, now U.S. Pat. No. 6,790,207, which is a continuation-in-part of U.S. patent application Ser. No. 09/304,737, filed May 4, 1999, now U.S. Pat. No. 6,464,697, and a continuation-in-part of U.S. patent application Ser. No. 09/090,794, filed Jun. 4, 1998 and entitled "Method for Treating a Sphincter" (now abandoned).
In a general sense, the invention is directed to systems and methods for treating interior tissue regions of the body. More specifically, the invention is directed to systems and methods for treating dysfunctions of organs and tissue in the gastrointestinal tract.
Disorders of organs or tissue of the gastrointestinal tract can be caused by as neurological factors (such as abnormal nerve impulses) or by physical factors (such as excess tissue volume).
For example, intestinal motility (i.e., the contraction of intestinal muscles and the propulsion and movement of the lumenal contents) is controlled by nerves and hormones, as well as by electrical activity in the muscular wall of the intestine. There are several disorders that involve abnormal motility and result in abnormal and uncomfortable visceral sensations. These disorders can cause significant discomfort and distress in the absence of gross physical abnormality of the intestine.
For example, irritable bowel syndrome (IBS) is a common disorder of the intestines. IBS can lead to crampy pain, gassiness, bloating, and changes in bowel habits. Some people with IBS have constipation (difficult or infrequent bowel movements) others have diarrhea (frequent loose stools, often with an urgent need to move the bowels); and some people experience both symptoms intermittently. Sometimes the person with IBS has a crampy urge to move the bowels, but cannot do so. The cause of IBS is not known, and as yet there is no cure. IBS can be characterized as a functional disorder because there is no sign of disease when the intestine is examined, often IBS is just a mild annoyance, but for some people it can be disabling.
Dyspepsia is another example. Dyspepsia is literally translated as 'bad digestion" and is commonly known as indigestion. Motility-like dyspepsia causes persistent or recurring abdominal pain that is centered in the upper abdomen. People with motility associated dyspepsia also may experience bloating, nausea, burping and a feeling of fullness that occurs soon after eating. It is an extremely common symptom complex, affecting as much as one-fourth of the United States adult population.
There are other disorders affecting the gastrointestinal tract that are characterized by abnormal tissue conditions not associated with neural abnormalities.
The invention provides systems and methods that treat disorders of the gastrointestinal tract by applying one or more treatment agents to tissue at or near the region where abnormal neurological symptoms and/or abnormal tissue conditions exist. The treatment agent is selected to either disrupt abnormal nerve pathways, e.g., associated with dysmotility and/or discomfort, and/or to alleviate abnormal tissue conditions, e.g., to stiffen tissue in order to alleviate disease.
One aspect of the invention provides systems and methods that apply a selected treatment agent into contact with tissue at or in a region of the gastrointestinal tract where dysmotility and/or abnormal visceral sensations exist. The application of the treatment agent can provide relief from the pain and symptoms of nerve-related gastrointestinal disorders, such as irritable bowel syndrome or motility-like dyspepsia. Application of the treatment agent may also attenuate the dysmotility and alleviate the dysfunction itself. The systems and methods may be used as either a primary treatment modality, or may be applied before, during, or after some other primary intervention.
According to this aspect of the invention, the treatment agent includes at least one vanilloid compound. Presence of the vanilloid compound evokes a desired tissue response, which includes at least one of the following, e.g., the interruption of nerve impulses which leads to a reduction of the symptoms that are associated with abnormal nerve impulses, the diminution of pain impulses, the attenuation of the dysmotility, and/or the alleviation the disease state itself. The vanilloid treatment agent may be applied to surface tissue, or, alternatively, it may be injected into subsurface tissue. In one embodiment, the systems and methods can also apply energy to the tissue region td form at least one lesion in conjunction with application of the treatment agent.
Another aspect of the invention provides systems and methods that apply a selected treatment agent into contact with tissue at or in a region where an abnormal tissue condition exists in order to affect normal functionality.
According to this aspect of the invention, the treatment agent includes at least one sub-type of a cytokine. Presence of the cytokine evokes a desired tissue response, which can include, e.g., an initiation of a localized healing process including influx of white blood cells and fibroblasts, followed by deposition of collagen, and subsequent tissue compliance reduction and tightening. These effects will result in a reduction of tissue volume. The cytokine treatment agent may be applied to surface tissue, or, alternatively, it may be injected into subsurface tissue, including the submucosa.
Features and advantages of the inventions are set forth in the following Description and Drawings, as well as in the appended Claims.
The invention may be embodied in several forms without departing from its spirit or essential characteristics. The scope of the invention is defined in the appended claims, rather than in the specific description preceding them. All embodiments that fall within the meaning and range of equivalency of the claims are therefore intended to be embraced by the claims.
This Specification discloses various systems and methods for treating dysfunctions of organs or tissue in the gastrointestinal tract. Still, it should be appreciated that the disclosed systems and methods are applicable for use in treating other dysfunctions elsewhere in the body, e.g., for treating sphincter barrier dysfunctions in the lower gastrointestinal tract or in the upper gastrointestinal tract. The systems and methods that embody features of the invention are adaptable for use with catheter-based systems and surgical techniques, as well as systems and surgical Techniques that are not necessarily catheter-based.
I. System Overview
A tissue treatment system 10 that embodies features of the invention is shown in
A. The Tissue Treatment Device
The tissue treatment device 12 serves to apply the treatment agent 20 to the targeted tissue region 16 to obtain a desired therapeutic effect. The therapeutic effect can comprise either alteration of nerve impulse pathways in the region 16 or a physical alteration of tissue characteristics in the region 16.
The tissue treatment device 12 includes one or more agent delivery ports 22. The one or more delivery ports 22 can apply the treatment agent 20 to surface tissue in the region 16. Desirably (as
The tissue treatment device 12 can include single or multiple ports 22 located single or multiple tissue piercing members 24 to inject the treatment agent 20. As
Alternatively, the tissue treatment device 12 may employ air powered, needle-less injection technology.
B. The Delivery Device
The configuration of the delivery apparatus 14 for the device 12 can also vary, depending upon the accessibility of the treatment site and the particular treatment objectives desired.
If the treatment site can be directly visualized the delivery apparatus 14, the source 18, and the treatment device 12 can comprise a syringe 100 and a needle 102, as
If the treatment site can not be directly visualized or is otherwise not as readily accessible, the delivery apparatus 14 can comprise an endoscope 106 having an interior lumen 104 passed down the esophagus through the mouth, as
C. The Tissue Treatment Agent
The treatment agent 20 is selected from a group of candidate agents based upon the physiologic effect or effects that are desired. One or more candidate agents may be applied, either as a primary treatment modality, a neoadjuvent treatment modality, or an adjuvent treatment modality.
In the illustrated embodiment, the group consists essentially of two candidate agents: (1) Vanilloid Compounds, and (2) Cytokine Sub-Types.
The treatment agent 20 can comprise a vanilloid compound. Vanilloid compounds have a unique capacity to bind to a membrane receptor in sensory neurons. Capsaicin is one of many vanilloid compounds. Capsaicin is a powerful basic compound which is derived from chili peppers.
The specific neuron for capsaicin is deemed "VRl". This receptor is expressed only on small unmyelinated C-fibers (nerves typically involved in special visceral sensation and pain).
Exposure to vanilloid compounds variably reduces the responsiveness of the neuron to stimuli. In many cases, the neuron may actually degenerate either temporarily or permanently, thus impairing transmission of pain signals or other special sensory signals.
The term "vanilloid compound" as used herein means a compound or a mixture of compounds having a biologically active vanillyl group. vanilloid compounds include both naturally occurring vanilloids, synthetic vanilloids, pharmaceutically acceptable salts of the vanilloid compound (whether natural or synthetic) as well as pharmaceutically acceptable derivatives and/or analogues thereof (whether natural or synthetic). Examples of natural vanilloid compounds include both the crude extracts and the purified extracts of active vanilloid compounds from: capsicum, cayenne pepper, black pepper, paprika, cinnamon, clove, mace, mustard, ginger, turmeric, papaya seed and the cactus-like plant Euphorbia resinifera.
Synthetic vanilloid compounds such as synthetic capsaicin are disclosed in WO 96/40079, which is incorporated herein by reference. The vanilloid compound family includes: Capsaicin; Dihydrocapsaicin: Nordihydrocapsaicin; Homocapsaicin: Homodihydrocapsaicin. Alternatively, resiniferotoxin (RTX) is derived from the euphorbia cactus and is considered a capsaicin-like compound. This substance also activates the VRl receptor and attenuates or eliminates afferent nerve function, although it may not illicit the rapid heat sensation that other vanilloids produce.
Other examples of vanilloid compounds include capsaicin ((E)-(N)-[(4-hydroxy-3-methoxyphenyl)-methyl]-8-methyl-6-nonenamide); eugenol(2-methoxy-4-(2-propenyl)phenol);zingerone(4-(4-hydroxy-3-methoxyphenyl)-2-butanone); curcumin(1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione); piperine(1-[5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine); resiniferatoxin(6,7-deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-20-(4-hydroxy-3effective salts, analogues, derivatives or equivalents thereof.
The treatment agent 20 can include capsaicin, another vanilloid compound, RTX, or combination thereof, alone or in combination with other substances (which will be generically called a vanilloid-containing treatment agent 20).
The vanilloid-containing treatment agent can be applied through the port 22 or ports 22 to the mucosal lining or extrinsically to the outside of an organ. The vanilloid-containing treatment agent can also be injected into the targeted tissue region or organ wall.
The treatment agent 20 can be a solution, a gel, a powder, a pellet, or other form. The treatment agent may be released immediately, or, be a sustained release product such as a slow released implant, slow release gel, coated pellet, microsphere, or other form.
The vanilloid-containing treatment agent 20 may be applied or injected as primary therapy, or, as a neoadjuvant or adjuvant procedure. For example, RF energy may be used to incite a wound, followed by application of the vanilloid-containing treatment agent to facilitate exuberant wound healing.
In dyspepsia and irritable bowel syndrome, the use of a vanilloid-containing treatment agent can serve to diminish the pain impulses or could attenuate the dysmotility and alleviate the disease state.
An example of vanilloid materials that can be used is produced by Afferon and is called RTX, which has been instilled into the lumen of the urinary bladder for the treatment of urge incontinence. There are also several topical, over-the-counter capsaicin products for topical analgesic applications.
2. Cytokine Sub-Types
The treatment agent 20 can include one or more subtypes of cytokines. A cytokine, in the natural state within the body, is a protein produced and released by a biological cell that has an effect on the local environment surrounding the cell. Cytokines are involved in many cellular processes, such as wound healing. The mechanism of action would depend on the specific cytokine utilized.
The term "cytokine subtype" as used herein means any polypeptide that affects the functions of other cells, and is a molecule which modulates interactions between cells in the immune or inflammatory response. A cytokine subtype includes, but is not limited to monokines and lymphokines regardless of which cells produce them. For instance, a monokine is generally referred to as being produced and secreted by a mononuclear cell, such as a macrophage and/or monocyte but many other cells produce monokines, such as natural killer cells, fibroblasts, basophils, neutrophils, endothelial cells, brain astrocytes, bone marrow stromal cells, epideral keratinocytes, and B-lymphocytes. Lymphokines are generally referred to as being produced by lymphocyte cells. Examples of cytokine subtypes include, but are not limited to, interleukin-1. (IL-l), tumor necrosis factor-alpha (TNF alpha) and tumor necrosis factor beta (TNF beta).
Other cytokine subtypes include TGF-β (transforming growth factor β); PDGF (platelet derived growth factor) b-FGF (basic fibroblast growth factor): IGF-l (insulin-like growth factor 1); EGF (epidermal growth factor); and VEGF. Some of these cytokines are available commercially, could be produced commercially, or can be extracted from a persons harvested platelets (platelet releasates). The effects of a given cytokine upon tissue physiology can include one or more of the following: smooth muscle and fibroblast mitogenic effects (induces division and growth of cells); stimulation of the release of cytokines from other cells; chemoattractant (bringing new healing cells into local region); decrease of collagen enzyme activity allowing collagen to build up; inflammation; and angiogenesis (development of new blood vessels).
The treatment agent 20 can include a cytokine sub-type or combination of cytokine sub-types, alone or in combination with other substances. The cytokine-containing treatment agent can be applied by the port or ports 22 to the tissue or organ wall, or injected into the tissue or organ wall.
The cytokine-containing treatment agent 20 can be a solution, a gel, a powder, a pellet, or other form. The treatment agent may be released immediately, or, be a sustained release product such as a slow released implant, slow release gel, coated pellet, microsphere, or other form.
The cytokine-containing agent 20 may be applied or injected as primary therapy, or, as a neoadjuvant or adjuvant procedure. For example, radio frequency (RF) energy may be used to induce the wound healing process, followed by cytokine application to facilitate more exuberant wound healing.
The application of a single cytokine or mixture thereof, as primary, neoadjuvant, or adjuvant therapy for abnormal tissue conditions (e.g., excess tissue volume) could have the various mechanical and therapeutic effects. With or without an inciting wound event (such as RF), cytokines can serve to initiate the process of healing within the local region. This process includes, but is not limited to, influx of white blood cells and macrophages, stimulation of fibroblast and smooth muscle division and collagen secretion, new blood vessel growth, wound contraction and tightening, maturation of the new or existing collagen framework, and reduced tissue compliance. These tissue effects could improve the compliance and reduce the tissue volume.
Examples of cytokine materials that can be used include commercially available Regranex, which is recombinant human PDGF-BB. This material has been applied as a gel for promoting the healing of diabetic foot ulcers. Platelet granules contain many of the cytokines listed above, and the cytokines can be extracted with a fairly simple technique (platelet releasates). Platelets (harvested as a pooled platelet product or from autologous donation) provide a source of cytokines for extraction. TGF-β and PDGF are considered to be the most important substances for the purpose of initiating the wound healing process.
Various features of the invention are set forth in the following claims.
|Cited Patent
|Filing date
|Publication date
|Nov 5, 1928
|Mar 31, 1931
|Raney Edwin M
|Surgical instrument
|Feb 8, 1968
|Jun 23, 1970
|Hines James R
|Surgical expanding arm dilator
|May 31, 1973
|Aug 26, 1975
|Al Corp Du
|Disposable cryosurgical instrument
|Mar 28, 1975
|Mar 15, 1977
|Olympus Optical Co., Ltd.
|Electrical apparatus for treating affected part in a coeloma
|Jan 31, 1978
|Apr 8, 1980
|Frecker William H
|Tongue locking device
|Oct 24, 1980
|Feb 2, 1982
|The Procter & Gamble Company
|Method of producing analgesia
|Sep 24, 1980
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|International Classification
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text:
Add the Twins to the list of teams that have interest in Masahiro Tanaka, 1500ESPN.com's Darren Wolfson reports. Wolfson does, however, quote a Twins official who says Tanaka's posting is a "long process" and it's "difficult to know where it stands."
#MNTwins official on Tanaka: "Long process & very difficult to know where it stands." Nonetheless, Twins, like many teams, are interested.
— Darren Wolfson (@DarrenWolfson) December 28, 2013
For more on this story visit: Charlie Wilmoth, MLB Trade Rumors


text:
Clipper Cuts: Salon Or Barber?With this year's fashion for ladies buzz cuts, it's important to advise that almost all the shaving is actually happening
at barbershops rather than salons. There are a number of reasons for this. Many salons will refuse to shave off a girl's
hair out of a lack of confidence. They are afraid of a negative reaction when the hair starts tumbling to the floor, which
makes the first clippering, especially from long, intimidating for the hairdresser. Also salons are usually nervous of doing
an all over headshave as they just don't have the experience. Barbers do it all the time, and do not argue or refuse, so you
better make your mind up first because a barber/barberette will have the clippers through your hair as soon as you agree
the length. This is good as a way of overcoming your nerves and you'd better get used to all the attention. This starts
when you're in the chair with the barber razoring off your locks and will continue as you will be turning heads.
My salon, however, is not missing out on the trend as we do ladies buzzcuts regularly. Usually they come in as groups
especially for the first shave. Remember, barbershops will do a more precise crewcut with better tapering and finish but
be sure you want it before you walk into the barbershop and sit in that big chair. HAVE FUN!
Nothing like the feel of a good clipper cut. The feel of the hair clipped is so erotic. I love to feel a freshly cut head whenever I can. Its been 2 years since you wrote this. Is your hair still buzzed?
I've never in my life heard of a beauty salon refusing to buzz off all of a chicks hair and I doubt you'd find any that would refuse to shave a woman's head with a razor either. Anyway, short and sexy haircuts for chicks is where it's at. Buzzed sides and nape are super hot.
I love to have it all buzzed off.
and where might this salon be?
i do my own clipper cuts, about twice a month to keep my style looking neat :) also the men in my family come get theirs done by me. xx
Really, any reason why not?
One can tell that you certainly enjoy your work!


text:
(jargon) To figure out something by meditation or by a sudden flash of enlightenment. Originally applied to bugs, but occasionally applied to problems of life in general. "How'd you figure out the buffer allocation problem?" "Oh, I zenned it."Contrast grok, which connotes a time-extended version of zenning a system. Compare hack mode. See also guru.
Last updated: 1996-09-17


text:
The Carbios-INRA project will focus on the development of innovative bioprocesses for recovering plastic waste and producing biopolymers.
Carbios and INRA are both members of the TWB research center [2] and will share know-how, expertise and human & technical resources over a five-year period. The goal is to develop effective biobased industrial processes that (as an alternative to conventional chemistry) add value to plastic waste and enable the production of economically competitive biosourced polymers.
The multidisciplinary collaboration will include R&D staff from TWB, the 3BCar Carnot Institute and two INRA groups (from the MICALIS laboratory in Paris and the Biological Systems and Processes Engineering Laboratory from INSA Toulouse, both of which are led by Alain Marty, Emeritus Professor of Enzymology). The INRA groups will focus on enzyme screening, enzymatic catalysis and cell engineering.
This project will enable Carbios to better address environmental, societal and economic issues concerning the recovery of plastic waste. Intensive exploitation of plastics means that over 100 million tons of plastic waste is generated worldwide every year. This alarming environmental issue has prompted a collective awareness of the need to find alternative production and consumption paradigms for a sustainable, environmentally responsible future. Carbios is developing innovative industrial solutions for transforming plastic waste into a novel, high-quality, renewable raw material for the plastics industry. The company offers a viable economic alternative to the depletion of agricultural resources (which might better be used to feed people) and the rarefaction of fossil fuels.
Carbios CEO Jean-Claude Lumaret commented that "although Europe generates almost 25 million metric tons of plastic waste each year,[3] only 20% of that is recycled. The recovery of such an important renewable resource is a key business issue. We are delighted to have signed this partnership agreement with LISBP and Micalis - two INRA R&D groups that are internationally renowned for their know-how and expertise in enzymatic bioprocesses. By combining our skills and resources, the resulting synergy will be an impressive driver for innovation and the development of breakthrough industrial bioprocesses".
François Houiller (Chief Executive, INRA) added that. "This exciting partnership with Carbios at TWB represents one of the highest-value collaborations ever between INRA and a start-up. Carbios has convinced us of their solid technical and industrial expertise. The collaboration will enable us to pool our know-how and will underpin applied research, with the shared objective of exploiting renewable resources".
Pierre Monsan (founder of the TWB research center) concluded by saying "we are thrilled to welcome Carbios, a company that meets all our criteria for collaborative projects. TWB is promoting innovative industrial biotechnologies as part of its support for the emergence of a bio-economy based on renewable carbon."
The €7 million collaboration will be included in the THANAPLASTTM consortium's overall budget of €22 million over five years. This consortium will bring together 60 researchers and will also receive €9.6 million in financial support from the French state innovation agency OSEO as part of the latter's Strategic Industrial Innovation program. CARBIOS (as the project's initiator and leader) will contribute most of the budget (€15 million) and will receive €6.8 million of the €9.6 million provided by OSEO.
THANAPLAST™ is seeking to create industrial value from plastics that have come to the end of their useful lives. The consortium will leverage biological catalysts with exceptional properties (e.g. resistance to heat, extreme pH and specific chemical reactions) and will develop and patent innovative technologies for producing, transforming and recycling a broad range of plastic materials.
About Carbios
Carbios is a young innovative green chemistry company whose mission is to find biological solutions to environmental and sustainable development issues faced by industrial businesses. The company is part of the "circular economy", which exploits and reuses waste. Carbios is developing innovative industrial bioprocesses for optimizing the technical, economic and environmental performance of polymers (including thermoplastic materials and synthetic or food-based fibers) by leveraging the unique properties of biological catalysts (enzymes). The company has initially chosen to focus its work on a strategic application sector: plastics. Carbios' growth strategy is based on a clear business model for industrial value creation that targets attractive markets, develops innovative, competitive bioprocesses and licenses them to major industrial stakeholders for commercialization. The company is positioning itself as an intermediary between basic research and industrial companies. Carbios was founded in 2008 with financial support from the leading European venture capital firm Truffle Capital[4] via the latter's Holding Incubatrice Série I Chimie Verte[5] fund. For more information, please visit: www.carbios.fr
Emmanuel Maille - Director of Corporate and Business Development.
Web site: www.carbios.fr
Caroline Carmagnol - +33 6 64 18 99 59 - firstname.lastname@example.com
Christian Berg - +33 1 42 68 86 41 -
About INRA: www.inra.fr
David Charamel
06 31 71 19 07
Lise Poulet
About TWB: www.toulouse-white-biotechnology.com
Pierre MONSAN
email@example.com / 05 61 55 94 15


text:
When Final Fantasy All the Bravest was first teased, fans believed that it was a port of Final Fantasy V or even Final Fantasy VI for iOS. Sadly this wasn't the case and it ended up being a brand new Final Fantasy game that depending on how you look at it, probably isn't worth your time or money.
Requiring no real skill, All the Bravest tasks you with using the famed system to defeat enemies by essentially swiping your finger across the screen over and over again.
To start off, you're given a Warrior from Final Fantasy I, but more characters will appear as you progress the game. The list of characters consists of classes from the original Final Fantasy through to Final Fantasy V. Selecting moves, items, magic etc. is non-existent. All character sprites get a small meter that must fill up before they are able to attack again. Simply touch a sprite and they will attack one of the enemies on the other side of the screen.
Enemies can kill you in one hit without fail and if you lose all of your characters the game asks you if you want to revive your party with an hourglass or a continue. Despite charging for the game, after using up your three "free" hourglasses, you're asked to pay an addition $0.99 if you want any more. If you don't want to spend the money, the game pauses right where your party met their demise and you have to wait until your party is revived. After a while the game will remind you with a notification that your party is back.
Sometimes during battles the game will go into fever mode and play the familiar Chocobo theme. Now it's your job to go all out and poke each sprite in your party as many times as you can. Again this requires no skill or decision making what so ever.
Gil and weapons are almost pointless and are best described as collectables. There are no stat screens, but apparently the weapons you find by defeating monsters and bosses can give you a bit of a boost stats such as attack or magic. Your gil count is basically a score that sits there without having anyway to spend it. No character interaction between shop keepers is present.
Now we get to the heart of the problem of Final Fantasy ATB, the downloadable content. Square Enix has used downloadable content to bring in the dough before but this game takes the cake.
In order to receive any premium Final Fantasy characters for your party you must spend $0.99 for each one. However, you can't even choose the character to buy. And on top of that if you were expecting to buy a favourite character such as Cloud or Lightning you might get a gag character such as a pig. If you really want to give Square Enix your money then spend $3.99 for each new map of iconic locations such as Midgar or Zanarkand. However, even those don't really alter the experience - it's just the same old thing in a different setting.
It feels as though Square Enix has really let the fans down with this iOS game. If you can look past the freemium model that you're asked to pay for, the gameplay is decent, but Square Enix shouldn't have to resort to this kind of gig to bring in the funds.
What was once a tease that made players hopeful for ports or even a remake, turned out to nothing but a crude disappointment. If you are expecting to go into Final Fantasy All the Bravest looking for a classic, you will be sorely disappointed. There's also a good chance you'll feel that way even if you go into it with an open mind.
When Final Fantasy All the Bravest was first teased, fans believed that it was a port of Final Fantasy V or even Final Fantasy VI for iOS. Sadly this wasn't the case and it ended up being a brand new Final Fantasy game that depending on how you look at it, probably isn't worth your time or money.


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Do you have a piece of furniture that needs a new look? And you have the patience and intestinal fortitude to transform said piece of furniture with fabric and Mod Podge? Then this project is for you. Maggie covered her entire IKEA Billy bookshelf with fabric and it looks like something you would pay a lot more money for. I'd recommend a bit of experience with Mod Podge before tackling a project like this, but it can be done. Learn more at the link below.
Bookshelf refresh at Maggie Rose Interiors


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Detail Information
- Cyclin H is targeted to the nucleus by C-terminal nuclear localization sequencesA Krempler
Department of Biophysics, University of the Saarland, Building 76, 66421 Homburg Saar, Germany
Cell Mol Life Sci 62:1379-87. 2005..Phosphorylation in the vicinity of the NLSs by cyclin C/cdk8 or protein kinase CK2, however, does not influence the nuclear translocation of cyclin H...
- Detection of a polymorphic 27 bp insertion/deletion in exon 4 of the canine calcitonin/calcitonin gene-related peptide gene I (CALCA)S Wende
Institute of Veterinary Medicine, University of Gottingen, Germany
Anim Genet 31:238-9. 2000
- Molecular analysis and chromosomal assignment of the canine CALC-I/alpha-CGRP geneS Wende
Institute of Veterinary Medicine, University of Gottingen, Groner Landstrasse 2, 37073 Gottingen, Germany
Mamm Genome 11:736-40. 2000..31 kDa (pI 7.9) and 14.13 kDa (pI 8.5) of the calcitonin and alpha-CGRP precursor, respectively...