text:
Research Topics
Genomes and Genes
ciliary motility disorders
Summary: Disorders characterized by abnormal ciliary movement in the nose, paranasal sinuses, respiratory tract, and spermatozoa. Electron microscopy of the CILIA shows that dynein arms are missing. The disorders manifest as KARTAGENER SYNDROME, chronic respiratory disorders, chronic sinusitis, and/or chronic otitis.
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Publications158 found, 100 shown here
- Ciliary dyskinesia in the nose and paranasal sinusesM Jorissen
ENT Department, Head and Neck Surgery, , Leuven, Belgium
Acta Otorhinolaryngol Belg 51:353-66. 1997..However, these investigations are not always conclusive. Functional and ultrastructural ciliary evaluation after ciliogenesis in tissue culture is essential and crucial...
- When cilia go bad: cilia defects and ciliopathiesManfred Fliegauf
Department of Paediatrics and Adolescent Medicine, University Hospital Freiburg, 79106 Freiburg, Germany
Nat Rev Mol Cell Biol 8:880-93. 2007..Several molecular mechanisms involved in cilia-related disorders have been identified that affect the structure and function of distinct cilia types...
- MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesisCorey L Williams
Department of Cell Biology, University of Alabama, Birmingham, AL 35294, USA
J Cell Biol 192:1023-41. 2011....
- Modeling human disease in humans: the ciliopathiesGaia Novarino
Neurogenetics Laboratory, Institute for Genomic Medicine, Howard Hughes Medical Institute, Department of Neurosciences and Pediatrics, University of California, San Diego, La Jolla 92093, USA
Cell 147:70-9. 2011..Sitting at the interface between simple and complex genetic conditions, these diseases provide clues to the future direction of human genetics...
- Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome)C Guichard
Laboratoire de Génétique Moléculaire Humaine, Equipe d Accueil 3088, Université C Bernard Lyon 1, 69373 Lyon Cedex 8, France
Am J Hum Genet 68:1030-5. 2001..Finally, this study demonstrates a link between ciliary function and situs determination, since compound mutation heterozygosity in DNAI1 results in PCD with situs solitus or situs inversus (KS)...
- The ciliopathies: a transitional model into systems biology of human genetic diseaseErica E Davis
Center for Human Disease Modeling, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
Curr Opin Genet Dev 22:290-303. 2012....
- Architecture and function of IFT complex proteins in ciliogenesisMichael Taschner
Max Planck Institute of Biochemistry, Department of Structural Cell Biology, Am Klopferspitz 18, D 82152 Martinsried, Germany
Differentiation 83:S12-22. 2012..In this review we will give an update on the knowledge of the structure and function of individual IFT proteins, and the way these proteins interact to form the complex that facilitates IFT...
- A meckelin-filamin A interaction mediates ciliogenesisMatthew Adams
Ciliopathy Research Group, Section of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, University of Leeds, Leeds LS9 7TF, UK
Hum Mol Genet 21:1272-86. 2012..Concurrent with these processes, the meckelin-filamin A signalling axis may be a key regulator in maintaining correct, normal levels of Wnt signalling...
- Tubulin tyrosine ligase-like 1 deficiency results in chronic rhinosinusitis and abnormal development of spermatid flagella in miceP Vogel
Lexicon Pharmaceuticals, Pathology Department, 8800 Technology Forest Place, The Woodlands, TX 77381 1160, USA
Vet Pathol 47:703-12. 2010....
- Disruption of a ciliary B9 protein complex causes Meckel syndromeWilliam E Dowdle
Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, 94158, USA
Am J Hum Genet 89:94-110. 2011..Our data indicate that B9d1 is required for normal Hh signaling, ciliogenesis, and ciliary protein localization and that B9d1 and B9d2 are essential components of a B9 protein complex, disruption of which causes MKS...
- Making sense of cilia in disease: the human ciliopathiesKate Baker
UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Am J Med Genet C Semin Med Genet 151:281-95. 2009..We review the common clinical phenotypes associated with ciliopathies and interrogate Online Mendelian Inheritance in Man (OMIM) to compile a comprehensive list of putative disorders in which ciliary dysfunction may play a role...
- Homozygosity mapping of a gene locus for primary ciliary dyskinesia on chromosome 5p and identification of the heavy dynein chain DNAH5 as a candidate geneH Omran
University Children s Hospital Freiburg, Freiburg University Hospital for Ear, Nose and Throat, Freiburg, Germany
Am J Respir Cell Mol Biol 23:696-702. 2000..On the basis of the Chlamydomonas model for PCD, this gene represents an excellent candidate for PCD...
- Ultrastructural expression of primary ciliary dyskinesia after ciliogenesis in cultureM Jorissen
ENT Department, UZ GHB, Leuven
Acta Otorhinolaryngol Belg 54:343-56. 2000..In conclusion, inherited abnormalities in primary ciliary dyskinesia are expressed after ciliogenesis, while secondary abnormalities are virtually absent, thereby facilitating the ultrastructural diagnosis...
- Primary ciliary dyskinesia: genes, candidate genes and chromosomal regionsMaciej Geremek
Institute of Human Genetics, Polish Academy of Sciences, 60 479 Poznan, Poland
J Appl Genet 45:347-61. 2004..In this review, the disease pathomechanism is discussed along with the genes that are or may be involved in the pathogenesis of primary ciliary dyskinesia and the Kartagener syndrome...
- Primary ciliary dyskinesia: age at diagnosis and symptom historyM E Coren
Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
Acta Paediatr 91:667-9. 2002..Mean age at diagnosis was 4.4 y despite a history of neonatal respiratory distress in 37/55 cases, situs inversus in 38/55 cases and early onset troublesome rhinitis in 42/55...
- Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesiaG Pennarun
Institut National de la Santé et de la Recherche Médicale U468, Hopital Henri Mondor, 94010 Creteil, France
Am J Hum Genet 65:1508-19. 1999..These data reveal the critical role of DNAI1 in the development of human axonemal structures and open up new means for identification of additional genes involved in related developmental defects...
- Ciliary defects and genetics of primary ciliary dyskinesiaEstelle Escudier
AP HP, Service de Génétique et d Embryologie médicales and Inserm U 933, Hopital Armand Trousseau, 26, avenue du Docteur Arnold Netter, 75571 Paris Cedex 13, France
Paediatr Respir Rev 10:51-4. 2009..The relative contribution of DNAI2 is currently being assessed. In all the other patients with ODA or other ultrastructural defects, the causative genes remain to be identified...
- Ciliary dysfunction in developmental abnormalities and diseasesNeeraj Sharma
Department of Cell Biology, University of Alabama at Birmingham, School of Medicine, Birmingham, Alabama, USA
Curr Top Dev Biol 85:371-427. 2008....
- Craniofacial ciliopathies: A new classification for craniofacial disordersSamantha A Brugmann
Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, California 94305, USA
Am J Med Genet A 152:2995-3006. 2010..Finally, we propose that some non-classified disorders may now be classified as craniofacial ciliopathies...
- The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndromeMarion Delous
Institut National de la Santé et de la Recherche Médicale INSERM U 574, Hopital Necker Enfants Malades, 75015 Paris, France
Nat Genet 39:875-81. 2007..Our findings show that mutations in RPGRIP1L can cause the multiorgan phenotypic abnormalities found in CORS or MKS, which therefore represent a continuum of the same underlying disorder...
- Discordant organ laterality in monozygotic twins with primary ciliary dyskinesiaP G Noone
Department of Medicine, University of North Carolina at Chapel Hill, 27599 7249, USA
Am J Med Genet 82:155-60. 1999..This is consistent with the hypothesis that situs inversus occurring in patients with primary ciliary dyskinesia is a random but "complete" event in the fetal development of patients with PCD...
- Meckelin is necessary for photoreceptor intraciliary transport and outer segment morphogenesisGayle B Collin
Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Invest Ophthalmol Vis Sci 53:967-74. 2012..In this study, the retinal morphology and ciliary function in a mouse model for Meckel Syndrome Type 3 (MKS3) throughout the course of photoreceptor development was examined...
- Identification of CC2D2A as a Meckel syndrome gene adds an important piece to the ciliopathy puzzleJonna Tallila
National Public Health Institute, Institute for Molecular Medicine Finland, Helsinki 00290, Finland
Am J Hum Genet 82:1361-7. 2008....
- The ciliopathies: an emerging class of human genetic disordersJose L Badano
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Annu Rev Genomics Hum Genet 7:125-48. 2006....
- The coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formationAnita Becker-Heck
Department of Pediatrics, University Hospital Freiburg, Freiburg, Germany
Nat Genet 43:79-84. 2011..CCDC40 localizes to motile cilia and the apical cytoplasm and is required for axonemal recruitment of CCDC39, disruption of which underlies a similar variant of PCD...
- Clinical and molecular features of Joubert syndrome and related disordersMelissa A Parisi
Center for Developmental Biology and Perinatal Medicine, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Boulevard, Bethesda, MD 20892 7510, USA
Am J Med Genet C Semin Med Genet 151:326-40. 2009....
- Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndromeHeleen H Arts
Department of Human Genetics, Radboud University Nijmegen Medical Centre and Nijmegen Centre for Molecular Life Sciences, 6500 HB Nijmegen, The Netherlands
Nat Genet 39:882-8. 2007..This work identifies RPGRIP1L as a gene responsible for JBTS and establishes a central role for cilia and basal bodies in the pathophysiology of this disorder...
- Cranioectodermal Dysplasia, Sensenbrenner syndrome, is a ciliopathy caused by mutations in the IFT122 geneJoanna Walczak-Sztulpa
Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin 14195, Germany
Am J Hum Genet 86:949-56. 2010..Still, by identifying CED as a ciliary disorder, our study suggests that the causative mutations in the unresolved cases most likely affect primary cilia function too...
- Axonemal localization of the dynein component DNAH5 is not altered in secondary ciliary dyskinesiaHeike Olbrich
Department of Pediatrics and Adolescent Medicine, University Hospital, Freiburg, Germany
Pediatr Res 59:418-22. 2006..DNAH5 localization is not altered by SCD, indicating a high potential for immunofluorescence analysis as a novel diagnostic tool in PCD...
- Simplified cell culture method for the diagnosis of atypical primary ciliary dyskinesiaM Pifferi
Department of Pediatrics, University of Pisa, Via Roma 67, 56126 Pisa, Italy
Thorax 64:1077-81. 2009..The diagnosis of primary ciliary dyskinesia (PCD) can be challenging, and it may be particularly difficult to distinguish primary ciliary disease from the secondary changes after infections...
- Function and ultrastructure of cilia in primary ciliary dyskinesiaH Felix
Klinik und Poliklinik für Otorhinolaryngologie, Hals und Gesichtschirurgie, Universitatsspital Zurich
Schweiz Med Wochenschr 130:699-704. 2000..e. after ruling out the other well known causes) with "situs inversus"...
- The secondary nature of ciliary (dis)orientation in secondary and primary ciliary dyskinesiaMark Jorissen
Department of ENT, Head and Neck Surgery, University Hospital Leuven, Leuven, Belgium
Acta Otolaryngol 124:527-31. 2004..The etiology, pathogenesis, consequences and relevance of ciliary (dis)orientation are still unclear...
- Success rates of respiratory epithelial cell culture techniques with ciliogenesis for diagnosing primary ciliary dyskinesiaM Jorissen
ENT Department, UZ GHB, Leuven
Acta Otorhinolaryngol Belg 54:357-65. 2000..In a total of 84 patients (10.3%) the final diagnosis was primary ciliary dyskinesia. Eighteen percent of the samples were considered normal, in 24% secondary ciliary dyskinesia was diagnosed...
- Genetic defects in ciliary structure and functionMaimoona A Zariwala
Department of Medicine, Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Annu Rev Physiol 69:423-50. 2007..Recent mutational analysis demonstrated that 38% of PCD patients carry mutations of the dynein genes DNAI1 and DNAH5. Increased understanding of the pathogenesis will aid in better diagnosis and treatment of PCD...
- Cilia-related diseasesB A Afzelius
Department of Zoophysiology, Arrhenius Laboratories F3, Stockholm University, SE 106 91 Stockholm, Sweden
J Pathol 204:470-7. 2004..Ciliary malfunctions due to genetic errors tend to be systemic and life-long, whereas acquired diseases are local and may be temporary only...
- Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndromeYosuke Kobayashi
Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Aichi 474 8522, Japan
Mol Cell Biol 22:2769-76. 2002..Collectively, Pol lambda(-/-) mice may provide a useful model for clarifying the pathogenesis of immotile cilia syndrome...
- Loci for primary ciliary dyskinesia map to chromosome 16p12.1-12.2 and 15q13.1-15.1 in Faroe Islands and Israeli Druze genetic isolatesD Jeganathan
J Med Genet 41:233-40. 2004
- Computer-assisted analysis helps detect inner dynein arm abnormalitiesEstelle Escudier
Unité fonctionnelle de biologie de la reproduction, Département de génétique, cytogénétique et embryologie, Groupe Hospitalier Pitié Salpêtrière AP HP, Paris
Am J Respir Crit Care Med 166:1257-62. 2002..Computer-assisted analysis of ciliary micrographs improves the characterization of inherited axonemal defects...
- Inner dynein arm defects causing primary ciliary dyskinesia: repeat testing requiredC O'Callaghan
Dept of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
Eur Respir J 38:603-7. 2011..Patients suspected of PCD due to an inner dynein arm defect or radial spoke defect should have the diagnosis reassessed if it has been based on only one diagnostic sample...
- A locus for primary ciliary dyskinesia maps to chromosome 19qM Meeks
Department of Paediatrics, Royal Free and University College Medical School, University College London, London WC1E 6JJ, UK
J Med Genet 37:241-4. 2000..3-qter at alpha (proportion of linked families) = 0.7. A 15 cM critical region is defined by recombinations at D19S572 and D19S218. These data provide significant evidence for a PCD locus on chromosome 19q and confirm locus heterogeneity...
- Biosynthesis of Wdr16, a marker protein for kinocilia-bearing cells, starts at the time of kinocilia formation in rat, and wdr16 gene knockdown causes hydrocephalus in zebrafishWolfgang Hirschner
Interfaculty Institute for Biochemistry, University of Tuebingen, Tuebingen, Germany
J Neurochem 101:274-88. 2007..Wdr16 can be considered a differentiation marker of kinocilia-bearing cells. In the brain, it appears to be functionally related to water homeostasis or osmoregulation...
- [Congenital immotile cilia--a rare syndrome of academic interest. An unexpected explanation why the heart ends up of the left side]Bjorn Afzelius
Avdelningen för zoofysiologi, Stockholms universitet
Lakartidningen 100:1148-9, 1152. 2003
- [The research progress of the nasal mucosal cilia]De Min Han
Zhonghua Yi Xue Za Zhi 83:172-4. 2003
- Cilia, primary ciliary dyskinesia and molecular geneticsR Chodhari
Department of Paediatrics and Child Health, Royal Free and University College Medical School, Bloomsbury Campus, Rayne Building, 5 University Street, WC1 E 6JJ, UK
Paediatr Respir Rev 5:69-76. 2004..This may also allow the development of new methods for diagnosis, prevention and treatment of PCD...
- The roles of cilia in developmental disorders and diseaseBrent W Bisgrove
Huntsman Cancer Institute Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
Development 133:4131-43. 2006..Here, we summarize an emerging view that in order to understand some complex developmental pathways and disease etiologies, one must consider the molecular functions performed by cilia...
- Ciliary ultrastructure in primary ciliary dyskinesia and other chronic respiratory conditions: the relevance of microtubular abnormalitiesM Lurie
Department of Pathology, Carmel Hospital, Technion Medical School, Haifa, Israel
Ultrastruct Pathol 16:547-53. 1992..Ciliary microtubular abnormalities of any kind were no more frequent in cases of primary ciliary dyskinesia than in other cases. The same was true for transposition and radial spoke defects...
- Cilia: tuning in to the cell's antennaWallace F Marshall
Department of Biochemistry and Biophysics, University of California San Francisco, 600 16th St, San Francisco, California 94143, USA
Curr Biol 16:R604-14. 2006..While these diseases highlight the pivotal roles of cilia in physiology and development, the mechanistic link between cilia, physiology, and disease remains unclear...
- [Comparison of the mucociliary transport rate of rhinitis sicca and atrophic rhinitis]Xiaotong Zhang
Department of Otolaryngology, Second Hospital of Xi an Jiaotong University, Xi an 710004
Lin Chuang Er Bi Yan Hou Ke Za Zhi 17:646-7, 649. 2003..To study the mucociliary transport function of rhinitis sicca and atrophic rhinitis, and to explore the standard of diagnosis...
- Nasal ciliary beat after insertion of septo-valvular splintsG Piatti
Institute of Respiratory Diseases, Ospedale Maggiore di Milano, IRCCS, University of Milan, Italy
Otolaryngol Head Neck Surg 130:558-62. 2004..We evaluated the local tolerance of a newly shaped device, the Guastella/Mantovani splint (G/M-SVS), with respect to the physiological mechanism of mucociliary clearance...
- Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disordersWilliam J Snell
Department of Cell Biology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell 117:693-7. 2004....
- Obstructive azoospermia associated with chronic sinopulmonary infection and situs inversus totalisKentaro Ichioka
Department of Urology, Kurashiki Central Hospital, Kurashiki, Okayama, Japan
Urology 68:204.e5-7. 2006....
- [Primary ciliary dyskinesia in situs inversus without bronchiectasis]J Gierich
, Fachkliniken Wangen,
Pneumologie 51:1127-32. 1997..Early start of the life-long treatment depends on early diagnosis which should be based on well-defined criteria...
- [The circadian rhythm of ciliary beat frequency of human nasal cilia in probands with healthy lungs and in patients with chronic obstructive lung disease. Includes adrenergic stimulation by terbutaline]A Thomas
Ruhrlandklinik, , Essen-Heidhausen
Pneumologie 47:526-30. 1993..9 Hz). In contrast to, neither a circadian variation of the ciliary beat frequency nor a stimulation by terbutaline could be observed in a group of fifteen patients with chronic bronchitis or bronchiectasis at 600, 1200, 1800 and 2400...
- Polycystic kidney disease--the ciliary connectionAlbert C M Ong
Sheffield Kidney Institute, Division of Clinical Sciences North, University of Sheffield, S5 7AU, Sheffield, UK
Lancet 361:774-6. 2003..Autosomal dominant PKD is one of the most common human genetic diseases and results from mutations in PKD1 or PKD2. These genes encode two proteins, polycystin-1 and polycystin-2...
- Clinicopathologic reports, case reports, and small case series: usher syndrome type 1 associated with primary ciliary aplasiaGian Marco Tosi
Arch Ophthalmol 121:407-8. 2003
- Abnormal central complex is a marker of severity in the presence of partial ciliary defectA Tamalet
Pediatric Pulmonology and ENT Departments, Armand Trousseau Hospital (AP-HP, Paris, France
Pediatrics 108:E86. 2001..Detection of CC abnormalities is a marker of severity and required intensive therapy and close follow-up...
- Culture of cells harvested with nasal brushing: a method for evaluating ciliary functionElina Toskala
Department of Otorhinolaryngology, Tampere University Hospital, Tampere, Finland
Rhinology 43:121-4. 2005..Usefulness and reliability of nasal brush samples in a monolayer cell culture was studied for evaluation of ciliary movement...
- Ultrastructural ciliary findings in nasal obstructive diseasesS Monini
Department of Otorhinolaryngology, II Medical School of the University La Sapienza, Rome, Italy
Rhinology 43:251-6. 2005..According to the findings derived from this study, mechanical nasal obstruction seems to cause major alterations on the nasal ciliary arrangement, thus determining a functional impairment on the whole nasal function...
- [Clinical and ultrastructural features of ciliary dyskinesia]Rodrigo Iñiguez C
Departamentos de Otorrinolaringología, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile
Rev Med Chil 135:1147-52. 2007..Ciliary dyskinesia (CD) is a low incidence genetic illness, that presents with a wide clinical spectrum. Also, there are transitory conditions that present with ciliary anomalies, secondary to infectious diseases of the airways...
- Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesiaL Bartoloni
Division of Medical Genetics, University of Geneva Medical School and, Geneva, Switzerland
Genomics 72:21-33. 2001..In the absence of pathogenic mutations, the DNAH9 gene has been excluded as being responsible for autosomal recessive PCD in these families...
- The human dynein intermediate chain 2 gene (DNAI2): cloning, mapping, expression pattern, and evaluation as a candidate for primary ciliary dyskinesiaG Pennarun
Institut National de la Santé et de la Recherche Médicale U468, H pital Henri Mondor, Creteil, France
Hum Genet 107:642-9. 2000..No mutation was found in the DNAI2 coding sequence of the twelve patients investigated. However, ten intragenic polymorphic sites and an EcoRI RFLP have been identified, allowing the exclusion of DNAI2 in three consanguineous families...
- Microtubular discontinuities as acquired ciliary defects in airway epithelium of patients with chronic respiratory diseasesJ L Carson
Department of Pediatrics and Cell Biology and Anatomy, University of North Carolina at Chapel Hill
Ultrastruct Pathol 18:327-32. 1994..These data provide evidence that ciliary microtubular discontinuities represent acquired ciliary defects reflective of chronic airway disease injury and are not components of a primary structural abnormality in PCD...
- [Immotile cilia syndrome--ultrastructural deviations of the nasal cilia]J Byloos
Brugmann-Kinderziekenhuis, Dienst K.N.O, Brussel
Acta Otorhinolaryngol Belg 43:515-21. 1989..Dyskinetic or dysfunctional cilia result clinically in the immotile-cilia syndrome. Differentiation between congenital and acquired anomalies is important. An early diagnosis as part of the therapeutic approach should be considered...
- Correlation of presentation and pathologic condition in primary ciliary dyskinesiaGregory Y Chin
Department of Otolaryngology Head and Neck Surgery, University of Southern California Keck School of Medicine, Los Angeles, USA
Arch Otolaryngol Head Neck Surg 128:1292-4. 2002..To better characterize primary ciliary dyskinesia (PCD) and improve the diagnosis of this uncommon disorder...
- Ciliary structure in health and diseaseB A Afzelius
Arrhenius Laboratories F3, Stockholm University, Sweden
Acta Otorhinolaryngol Belg 54:287-91. 2000..The inborn disease named immotile-cilia syndrome is characterized by the cilia being defective. It is a highly heterogeneous disease in that more than a dozen subgroups characterized by different ciliary defects have been recognized...
- A two-cilia model for vertebrate left-right axis specificationClifford J Tabin
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 17:1-6. 2003
- Structure and function of mammalian ciliaPeter Satir
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY, USA
Histochem Cell Biol 129:687-93. 2008..This view has had unanticipated consequences for our understanding of developmental processes and human disease...
- [Ultrastructural changes of the nasal mucosa in primary ciliary dyskinesia]S Knipping
Universitätsklinik und Poliklinik für Hals, Nasen, Ohrenheilkunde, Kopf und Halschirurgie, Martin Luther Universitat Halle Wittenberg, Magdeburger Strasse 12, 06097 Halle Saale
HNO 50:483-7. 2002..Special attention should be given to ultrastructural changes of nasal or bronchial mucosa if a young patient suffers from recurrent severe respiratory infections...
- Nasal nitric oxide in atypical primary ciliary dyskinesiaMassimo Pifferi
University of Pisa, Department of Pediatrics, Via Roma 67, 56122 Pisa, Italy
Chest 131:870-3. 2007..Atypical cases of primary ciliary dyskinesia (PCD) may present with minimal transmission electron microscopy (TEM) defects. The diagnostic role of nasal nitric oxide (nNO) levels was evaluated in those patients...
- Ciliary function and the role of cilia in clearanceWendy Stannard
Division of Child Health, Department of Infection, Immunity and Inflammation, Institute of Lung Health, University of Leicester, Leicester, United Kingdom
J Aerosol Med 19:110-5. 2006..These defenses may be disrupted by viral and bacterial infections, by inhaled toxins, and by inherited diseases such as primary ciliary dyskinesia and cystic fibrosis...
- Genomic analysis of Meckel-Gruber syndrome in Arabs reveals marked genetic heterogeneity and novel candidate genesRanad Shaheen
Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Eur J Hum Genet 21:762-8. 2013....
- Primary ciliary dyskinesia: when to suspect the diagnosis and how to confirm itClaire Hogg
The Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Paediatr Respir Rev 10:44-50. 2009..Recent advances in the screening and diagnostic tests available will be outlined, as well as some future directions that aim to enhance the current diagnostic techniques...
- Bronchiectasis and sino-nasal disease: a reviewC M Philpott
Department of Otorhinolaryngology, Essex Rivers Healthcare NHS Trust, Colchester, UK
J Laryngol Otol 122:11-5. 2008....
- Analysis of genetic inheritance in a family quartet by whole-genome sequencingJared C Roach
Institute for Systems Biology, Seattle, WA 98103, USA
Science 328:636-9. 2010..Family-based genome analysis enabled us to narrow the candidate genes for both of these Mendelian disorders to only four. Our results demonstrate the value of complete genome sequencing in families...
- Ciliary syndromes and treatmentMichal Klysik
Texas Tech University Health Science Center, 4800 Alberta Ave, El Paso, TX 79905, USA
Pathol Res Pract 204:77-88. 2008..In this review, attempts are made to outline selected, yet key topics related to ciliary function in health and disease...
- Bronchiectasis in children with recurrent pneumonia: an immunopathological damage associated with secondary ciliary dysmotilityM Pifferi
Department of Pediatrics, University of Pisa, Pisa, Italy
Int J Immunopathol Pharmacol 21:215-9. 2008..Whether ciliary dysmotility is a cause or a consequence of anatomical lesion is a matter of speculation. Very likely there is an amplification and self-maintaining mechanism between the two events which may lead to more serious disease...
- Bronchiectasis: the consequence of late diagnosis in chronic respiratory symptomsDeniz Dogru
Department of Pediatrics, Pulmonary Medicine Unit, Hacettepe University, Ankara, Turkey
J Trop Pediatr 51:362-5. 2005..Early diagnosis and treatment will increase the quality of life and survival of patients with bronchiectasis, which has irreversible and progressive complications if untreated...
- Neutrophils potentiate platinum-mediated injury to human ciliated epithelium in vitroCharles Feldman
Division of Pulmonology, Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa
Inhal Toxicol 17:297-301. 2005..If such effects also occur in vivo they may play a role, at least partly, in the pathogenesis of airway disorders that may manifest in exposed workers...
- The Meckel syndrome protein meckelin (TMEM67) is a key regulator of cilia function but is not required for tissue planar polarityAmanda C Leightner
Department of Biochemistry and Molecular Biology, Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Hum Mol Genet 22:2024-40. 2013..Together, these data suggest that defective cilia loading, but not a global loss of ciliogenesis, basal body docking or PCP signaling leads to dysfunctional cilia in MKS3 tissues...
- Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesiaYan J Zhang
Cystic Fibrosis Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7248, USA
J Biol Chem 277:17906-15. 2002..In cilia from PCD cells, DNAH7 was undetectable, whereas intracellular DNAH7 was clearly present. These studies identify DNAH7 as an inner arm component of human cilia that is synthesized but not assembled in a case of PCD...
- Ups and downs of nitric oxide in chesty childrenSimon Godfrey
Institute of Pulmonology, Hadassah University Hospital, PO Box 12000, Jerusalem, Israel
Am J Respir Crit Care Med 166:438-9. 2002
- Primary ciliary dyskinesiaA Bush
Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK
Acta Otorhinolaryngol Belg 54:317-24. 2000..Patients should be followed up by specialists familiar with the different ways of managing the upper and lower airway complications...
- Pathophysiology and treatment of airway mucociliary clearance. A moving taleP Cole
Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
Minerva Anestesiol 67:206-9. 2001..Methods of rectifying this defect promise to restore MCC to normal and interfere in the vicious circle of inflammatory lung damage...
- Ciliary assessment in bronchiectasisK W Tsang
University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China
Respirology 5:91-8. 2000....
- Primary ciliary dyskinesia in a Staffordshire bull terrierM De Scally
Bryanston Veterinary Hospital, P O Box 67092, Bryanston, 2021, South Africa
J S Afr Vet Assoc 75:150-2. 2004..To the authors' knowledge, this is the first case of PCD described in the Staffordshire bull terrier and the first report of PCD in South Africa...
- A mammalian radial spokehead-like gene, RSHL1, at the myotonic dystrophy-1 locusM Eriksson
Department of Molecular Medicine and Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Biochem Biophys Res Commun 281:835-41. 2001..Expression of the mammalian homolog was detected in the adult testis. We suggest that this gene, which we have called Radial Spokehead-Like 1 (RSHL1), is a candidate gene for familial primary ciliary dyskinesia...
- From quantitative protein complex analysis to disease mechanismY Texier
Division of Experimental Ophthalmology and Medical Proteome Center, Centre for Ophthalmology, Eberhard Karls University Tubingen, Nägelestr 5, D 72074 Tubingen, Germany
Vision Res 75:108-11. 2012..This review focusses on some selected recent studies using affinity purification-based protein complex analysis, thereby exemplifying the great possibilities this technology offers...
- Earliest ultrasound findings and description of splicing mutations in Meckel-Gruber syndromeChristel Eckmann-Scholz
Department of Gynecology and Obstetrics, University Hospital Schleswig Holstein, Campus Kiel and Christian Albrechts University Kiel, Arnold Heller Straße 3, 24105 Kiel, Germany
Arch Gynecol Obstet 286:917-21. 2012..A splice site mutation in the MKS4 gene could be detected. Clinical management accounting risk assessment for future pregnancies is discussed and early ultrasound markers in MKS are described...
- [Pediatric pulmonology]H Bisgaard
H S Rigshospitalet, Børneafdelingen
Ugeskr Laeger 163:6391-5. 2001..This article summarises the status of this specialty, and the training syllabus, and highlights key research questions...
- Mutations in RPGRIP1L: extending the clinical spectrum of ciliopathiesOlivier Devuyst
Division of Nephrology, Université Catholique de Louvain Medical School, B 1200 Brussels, Belgium
Nephrol Dial Transplant 23:1500-3. 2008
- The cell biological basis of ciliary diseaseWallace F Marshall
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 180:17-21. 2008..The clinical complexity of the ciliopathies can therefore only be understood in light of the basic cell biology of the cilia themselves, which I will discuss from the viewpoint of cell biological studies in model organisms...
- Clinical variability in ciliary disordersKirk Mykytyn
Nat Genet 39:818-9. 2007
- Secondary ciliary dyskinesia in upper respiratory tractB Bertrand
ORL and HNS Department, Cliniques Universitaires de Mont Godinne, Yvoir, Belgium
Acta Otorhinolaryngol Belg 54:309-16. 2000..To distinct from ultrastructural images between primary and secondary ciliary dyskinesia is often uneasy because some of the findings in secondary ciliary dyskinesia obviously mimic those dedicated to primary ciliary dyskinesia...
- Unusual ciliary abnormalities in three 9/11 response workersJames T McMahon
Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Ann Otol Rhinol Laryngol 120:40-8. 2011....
- Liver and kidney disease in ciliopathiesMeral Gunay-Aygun
Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, 10 Center Dr, Bldg 10, Rm 10C103, Bethesda, MD 20892 1851, USA
Am J Med Genet C Semin Med Genet 151:296-306. 2009..This review focuses on the kidney and liver disease found in the different ciliopathies...
- Ciliary dyskinesia associated with hydrocephalus and mental retardation in a Jordanian familyM al-Shroof
Houston Medical Center, Warner Robins, GA 11554, USA
Mayo Clin Proc 76:1219-24. 2001..The unusual presentation of ciliary dyskinesia, hydrocephalus, and mental retardation may be due to a new genetic mutation...
- [Association between heroin consumption in pregnancy and structural abnormalities of the respiratory cilia in newborn infants]A Mur Sierra
Sección de Neonatología Servicio de Pediatría Hospital del Mar Universidad Autónoma de Barcelona
An Esp Pediatr 55:335-8. 2001..To describe structural abnormalities of the respiratory cilia in newborn infants whose mothers consumed heroin during pregnancy...
- Clinical application of nasal nitric oxide measurementS Carraro
Department of Pediatrics, Unit of Allergy and Respiratory Medicine, University of Padova, Italy
Int J Immunopathol Pharmacol 23:50-2. 2010..Particularly low concentrations have been described in children with primary ciliary dyskinesia, so nNO measurement has been proposed as a reliable screening test for this chronic lung disease...
- [Primary ciliary dyskinesia. report of three cases]R Busquets Monge
Servicios de Pediatría Anatomía Patológica, Hospital del Mar, Universidad Autonoma de Barcelona, Spain
An Esp Pediatr 54:513-7. 2001..Although the syndrome cannot be cured, as in other chronic pneumopathies, early diagnosis and appropriate treatment can considerably reduce morbidity...
- [Recombinant human DNase in conditions other than cystic fibrosis]Kim Kristensen
Paediatrisk klinik 2, 4072, Rigshospitalet, DK 2100 København Ø, Denmark
Ugeskr Laeger 172:616-9. 2010..There are no controlled studies on rhDNase in primary ciliary dyskinesia or atelectasis...
- Respiratory ciliary function in bone marrow recipientsW Y Au
University Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
Bone Marrow Transplant 27:1147-51. 2001..Further studies are indicated to evaluate this important phenomenon, which could be an important cause of the susceptibility for BMT recipients to respiratory infections...
Research Grants8
- Genetic Modifiers of CF Liver DiseaseMichael Knowles; Fiscal Year: 2008..Better understanding of the pathobiology of hepatic fibrosis in CF will identify novel targets to prevent (or reduce) the development of CFLD. ..
- Genetic Disorders of Mucociliary ClearanceMichael Knowles; Fiscal Year: 2008..Finally, we will work with the DTCC to coordinate and expand current websites to provide information to the lay public, patients, and medical professionals for education, referral, and recruitment of study subjects. ..
- Centriole Orientation During Left/Right Symmetry Breaking in the MouseWallace Marshall; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Small Molecule Inhibitors of CiliaWallace Marshall; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- SODIUM-CALCUIM EXCHANGE IN THE RENAL MICROCIRCULATIONPhillip Bell; Fiscal Year: 2003....
- Cellular Mechanisms for Tubuloglomerular FeedbackPhillip Bell; Fiscal Year: 2009..Overall these studies should provide important new information regarding the role of ATP in macula densa signaling, activation of the tubuloglomerular feedback mechanism, and control of glomerular hemodynamics. ..
- Zic3 and the Control of Body Pattern FormationSTEPHANIE WARE; Fiscal Year: 2005..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..


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At Gemvara, we believe that the jewelry you wear should be one of a kind, like you. That's why we make each piece to order, one at a time, just the way you want it. Choose alexandrite and rose gold or green amethyst and palladium: it's your choice. Mix and match gems and precious metals for a look that's exactly you. It's jewelry for all life's occasions, from an anniversary or holiday to your own personal milestones and celebrations. Celebrate her graduation with a brilliant gift of jewelry that will always remind her of you. Gemvara uses only the highest quality materials to craft your amethyst casual and fun jewelry design with meticulous attention to detail. Our precious metals are recycled or responsibly mined. Royal purple amethyst is the gem of tranquility. Tibetan Buddhists use amethyst rosaries to enhance the peace of meditation. Gemvara's amethyst is a rich purple color with exceptional cutting. Our wide selection of amethyst casual and fun jewelry by Ji Hwang, Damon Washington, Carl Ansley, and other talented designers means you can find jewelry that's exactly your style. You can also shop by style, choosing our Our Picks, Lucky Charm, or Featured Curation Collections. Gemvara's fine quality amethyst casual and fun jewelry is designed to be passed down for generations to come, crafted by hand in the United States.
We can help right away. Chat with a jewelry expert now!

subset: commoncrawl


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I had my first Active FX procedure done at the end of June 2009. I was given medication at the office that knocked me out. I didn't feel much while they were doing the procedure. I had it done at 9am and don't remember much until around 9pm. I slept in a recliner chair the first day and night.
I did nothing to my face the first day or night. I got up the next morning and started the aftercare procedure. I went out in public the second day with a hat and sunglasses. People asked about my face and I told them what I had done.
I was pleased with the results but still wanted more done around my eyes, my forehead and around my mouth. I went back at the end of February 2010 for a retouch to those three areas and I am very pleased.
I did take off work for the week after I had it done both times. Most people after the first week said I looked like I had a sunburned face.
I will do it again when I need it.


text: Vans Classic Slip-on Shoes - Black/White UK Size 6 (B-Stock)ConditionThese shoes are an ex-display model in generally good condition. The white soles of the shoes have gotten slightly dirty on display and the box has some slight wear & tear.Product DescriptionThe Classic Slip-Ons need no one to sing their praises; they have become such a part of skate culture and contemporary style, effortlessly proving their iconoclastic relevance from the skate spot to the big screen and every walk of life around the globe. Their popularity comes from unmatched quality, and they have hence become a big time influence on our Off The Wall efforts to innovate, every step of the way.Canvas uppers.Vulcanized waffle rubber outsoles.Solid colorways.Please note that this item is b-stock, reduced and as such is a one-off.Unfortunately we can only accept returns on b-stock items if they are faulty and reported within 14 days.Check stock and price


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Taj Mahal The symbol of Love is situated in Agra, The Taj Mahal of Agra is very famous India Tours as they take tourists closer to the monument of pure and eternal love. It is built by the Mughal emperor Shahjahan in memory of his beloved wife Mumtaz Mahal. Standing grandly on the banks of River Yamuna, the Taj Mahal is synonymous with love and romance.
The purity of the white marble, the delicate ornamentation, expensive gemstones used and its picturesque location, all make Taj Mahal travel increase a place amongst the most popular ones. The Taj Mahal Tours of India Agra is thus truly enthralling and visitors are charmed by the beauty and glory of such a great work of art. Tourists in large numbers flock at the venue of the monument.
It is Indias most renowned monument and is also one of the Seven Wonders of the World. The splendid Taj Mahal monument is more than 350 years old. A combined workforce of 20,000 people toiled hard for 22 years to build this structure, which clearly surpasses everything else in beauty and elegance. It is also amazing that the Taj Mahal in Agra cost the exchequer 32 million rupees even at that time.
India journey is incomplete without experiencing the Taj Mahal. This supreme temple of love has become the monument of a man's love for a woman. The color of the Taj changes with every change that takes place in the sky. The golden pink Taj at dawn turns into dazzling white at noon. Giving way to the sultry orange at sunset is the milky blue at night. Viewing the Taj on Full moon nights is a blissful experience. One visit to experience the architectural beauty of Taj is a must for everyone. And once there, you will obviously feel like re-visiting it.
During your Taj Mahal visit you will see that though its layout follows a distinctly Islamic theme, representing Paradise, it is above all monument to romantic love. Taj Mahal is regarded by most modern visitors on his Tours to India. Taj Mahal as the symbol of eternal love. Shah Jahan built the Taj to enshrine the body of his beloved wife, Mumtaz Mahal, who died shortly after giving birth to her fourteenth child in 1631.
The emperor was devastated by her death, and set out to create an unsurpassed monument to her memory- Its name, Taj Mahal is simply a shortened, informal version of Mumtaz Mahals palace title. Construction by a workforce of some 20,000 men from all over Asia commenced in 1632 and took over twenty years, not being completed until 1653.
Marble was brought from Makrana , near Ajmer in Rajasthan, and semi-precious stones for decoration were carried to Agra from Persia, Russia, Afghanistan, Tibet, China and the Indian ocean. When the emperor ShahJahan died in January 1666, his body was carried across the river Yamuna to lie alongside his beloved wife in his peerless tomb.


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My Link Page
Auomatic Link Building
Category List >
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Bad Debt
| Add Link
Page generated on Apr 2, 2014
Secondly, back links can work by popularity. What I mean by this is that if you get a high ranked site to back link to your site, this carries over. So that high ranked site's URL is in the back link and that further draws people to your website.
Lastly, you need to make sure the back links are relevant. The more off topic your back links are the more useless they are. You need links from websites similar to yours that deal with the same product or information. If you get back links that really have nothing to do with your website, they will be pretty much worthless.
Those three factors work in tandem with one another. Your back links should abide by all three of those. You need to make sure your links are relevant, try to get them from high ranked sites, and make sure you get a lot of them. If you do not do all three of those you wont be getting the most out of those links.
Link building Services are what allow you to get links that fit all those parameters. They can provide you with links from high ranked sites and that fit all those criteria.
However a lot of these services require a fee of some sort. On top of that they might remove your links if you cancel or quit. So when looking into such services make sure to do your homework and find one that works for you.
Another thing you should keep in mind is there are two types of back links. There is reciprocation and one way. Essentially the reciprocation back links are just as they sound. Their site will link to you but your site will also link to them. This can be a double edged sword since it makes you climb rank, but it also helps your competitors climb in rank as well.
The other link, the one way one, allows their site to link to yours without you linking toyours. This is the best one to use since it helps you climb up in rank without allowing them to climb up. It is also harder to get, but is also the type provided by link services.----------------------------------------------------------------------
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Byblos Bank chairman François Bassil expects the combined net profits of the Lebanese banking [2] sector to plunge by 5-10 percent at the end of 2012 due to political bickering and the volatile situation in neighboring Syria. "Our growth in assets and deposits will be close to 8 percent this year ... close to last year's figures. However, the net profits for all commercial banks may fall by 5-8 percent if the economy and political situation continue to deteriorate," Bassil told The Daily Star Monday in an interview at the bank's headquarters.
Some leading banks have actually seen their profits fall in the first quarter of this year despite adopting measures which attempt to contain the negative impact of both the economic slowdown and raging war in Syria. [3]
Most of these banks have increased their provisions for non-performing loans since the crisis in Syria started 16-months ago. This measure, which is seen as essential, has apparently affected the profitability of most of the leading banks. But the profits of the leading banks are still considered relatively high in spite of the fragile situation the country is experiencing.
The latest data on Lebanon's banking sector [4] revealed that the total assets held by Lebanese commercial banks reached $144.86 billion at the end of May 2012, up by 8.07 percent from May 2011 and 3.05 percent from December 2011
Banks claim to have wide cash surpluses, arguing that all they need is stability and more investment opportunities to diversify their revenues.
Bassil also expressed his deep indignation at the government's impotence and inability to address the crucial economic issues facing the sector. "I don't feel the presence of the government. The constant bickering between the ministers has driven the national economy to the brink of disaster," he said. Bassil said that Lebanese banks can easily use portions of their excess cash to finance some of the vital government projects.
"Investment opportunities abroad are scarce these days as a result of the economic recession in some European countries. It is natural we support the idea of investing part of our portfolio in government projects as part of the Public-Private-Partnership," he said. Bassil painted a bleak picture of the economy in general.
"Some agencies and the International Monetary Fund project a growth of 3 percent at the end of 2012. Frankly speaking I doubt we will have 1 percent growth if the situation does not improve," Bassil warned. He admitted that the deteriorating situation in Syria had proven devastating to both the Lebanese economy and tourism sector.
"What makes matters worse is the indifference of the government, which has failed to take any steps to contain the consequences of the deteriorating situation in Syria," Bassil said.
The recent campaign by the U.S. group United Against Nuclear Iran to discredit the reputation of the Lebanese banking sector was at the heart of comments made by Bassil, who vehemently dismissed all accusations of money laundering and terrorist funding.
"All of the U.S. officials who we met have praised the measures taken by Lebanese banks to curb any attempt to deal with Iranian and Syrian banks. We are complying strictly with all U.N. Security Council resolutions," Bassil said. He stressed that Lebanese banks never received Iranian funds.
"Since the liberalization of the Lebanese economy after the French withdrew from Lebanon, we have never received or dealt with Iranian banks or financial institutions. All of the foreign banks in Lebanon abide by the laws of the Central Bank," he said.
Some U.S. agencies have questioned how a small country like Lebanon with its relatively low GDP can have high assets and deposits in its banking system, and have suggested that most of these funds have been generated through illicit means.
"All of these reports are pure fabrication. Most of the deposits are from Lebanese expatriates in Africa, South America, Europe and oil-rich Arab countries," Bassil explained.
The former president of the Association of Banks in Lebanon also denied allegations that U.S. officials threatened to take punitive measures against Lebanese banks. "These reports are false and unfounded. U.S. officials want us to maintain our vigilance and prevent any attempt to launder money." He pointed out that Lebanese expatriates outnumber the residing Lebanese citizens.
Remittances and capital inflows, which amount to more than $8 billion a year, have buttressed the Lebanese economy and helped improve the balance of payments.
Bassil maintained that all Lebanese banks operating in Syria are refraining from granting new loans to Syrian citizens or accepting any new transactions.
"Naturally, deposits in Lebanese banks in Syria have shrunk since the crisis started. But we have no intention to exit this market – the country will eventually return to normal. Syria is still a promising market for Lebanese banks and for this reason we have no plans to leave it," he said.
[1] http://www.syndigate.info
[2] http://www.albawaba.com/business/lebanese-banks-government-debt-424869
[3] http://www.albawaba.com/lebanese-banks-will-abide-syria-sanctions-salameh-410274
[4] http://www.albawaba.com/business/lebanon-bank-deposits-425132
[5] http://www.dailystar.com.lb/


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Tiger Woods is taking an "indefinite" break from golf.
In a statement posted on his Web site on Friday afternoon, the headline-grabbing golf star admitted for the first time that he has been unfaithful.
"I am deeply aware of the disappointment and hurt that my infidelity has caused to so many people, most of all my wife and children," Woods wrote in the post. "I want to say again to everyone that I am profoundly sorry and that I ask forgiveness. It may not be possible to repair the damage I've done, but I want to do my best to try."
Woods offered his thanks to those that have stood by him over the last two weeks of headlines and the host of stories generated by the numerous alleged mistresses who have stepped forward with their stories.
"I would like to ask everyone, including my fans, the good people at my foundation, business partners, the PGA Tour, and my fellow competitors, for their understanding. What's most important now is that my family has the time, privacy, and safe haven we will need for personal healing," he wrote.
"After much soul searching, I have decided to take an indefinite break from professional golf. I need to focus my attention on being a better husband, father, and person," Woods' statement continued. "Again, I ask for privacy for my family and I am especially grateful for all those who have offered compassion and concern during this difficult period."


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Static html output option for SSI
I searched and didn't see any posts about this except for some comments I left in other posts.
I would love the ability to output my blog to html either as a whole or selectively. There are several php/cgi programs out there that do this kind of thing like Links 2.0 and X-cart.
My most pressing need is to easily output to a text file or static html file the text of my most recent post. Furthermore, I need the ability to specify how many characters to output. For example, I have a non-wordpress page that I would like add "Most Recent Blog Entry" to. There is room for only 500 characters but the most recent entry might be 1500 characters. I'd like to specify an output of 500 characters only, formatted or non-formatted, so that I may use a simple SSI (server side include) or PHP include on a non-wp page. CG-FeedReader works but requires me to change to a php file extension and that's not possible for page I'm working on. It also doesn't let you limit characters.
- The topic 'Static html output option for SSI' is closed to new replies.


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New Course REPEAT POLICY effective on Fall 2013 courses and beyond - READ THIS BEFORE YOU REGISTER
Repeating Courses—When a student repeats a course, the higher grade will be computed in the cumulative average. Grades from both attempts will remain on the transcript. A repeated course does not earn additional credit toward graduation unless the first attempt received a failing grade.
1. If a student's grade is lowered below the level required by the major due to academic dishonesty, the student may retake the course, but only with the agreement of the department chair and only on a pass/fail basis, even if the major has already been declared. The original grade remains on the student's transcript.
2. If a student fails a course due to academic dishonesty and the course is not required for the major, the student may not retake the course.
3. If a student's grade is lowered due to academic dishonesty and the course is not required with a higher grade for the major, the student may not retake the course.
4. In all other cases, a student who wishes to retake a course must submit a petition to the Academic Petitions Committee. The petition must provide a more in-depth explanation of the student's reason(s) for retaking the course than merely stating "to raise my GPA." Pending the Committee's approval, the student may register to retake the course only after the class-based portion of the pre-registration process is complete.
BE AWARE--financial aid or veterans' benefits may be affected by a repeated course. Students should contact the student financial services office to determine if repeating a course would jeopardize a grants or scholarships.


text:
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Gender: M Meaning of Damek: "son of the red earth" Origin of Damek: Slavic variation of Adam
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You Can't Scare Me, I Am An Arietes Sweatshirt
Product Color:
Product information
Sweatshirt You Can't Scare Me, I Am An Arietes is the all-time ultimate in comfort with its classic, relaxed fit. On the surface rich cotton with You Can't Scare Me, I Am An Arietes, inside flannel for the softest sensation. Medium to heavy weight ensuring warmth and makes it great, weather as a throw-over in rainy and windy weather or to protect against the snow and ice in the winter.
Crew-neck for those that don't like the common hood. Stretched cuffs and hem assure a lasting shape. Aries Sweatshirt comes in 12 basic colors. Heather Grey: 80% Cotton/20% Polyester. Remaining Colors: 100% Cotton.
Sku: SR1WH0000028021010100001SGRE00000


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What Do You Keep Open All Day?
In the past year, my web habits have changed more than in any year in recent memory. Whereas just a few years ago my web surfing consisted of visiting certain sites of interest at certain times of the day, I now have several tabs open all day in Firefox in which information is being constantly refreshed (either through the browser refresh button or AJAX). I think this has a lot to do with the web's move toward the functional utility and away from mere content.
When I look at what's so compelling about these particular sites and applications that makes me want to keep them in front of me all day, I notice they fall pretty neatly into three categories:
- Social
- Business applications
- Niche content
Some of them straddle lines, but mostly they're pretty clear cut. Let's look at what I keep open in my browser tabs all day:
- Wordpress Dashboard at Hespos.com (social) - This is the main command center for my blog at Hespos.com. If I want to type out a quick missive, or if a comment comes in from a reader, this is where it all happens.
- Message Boards (social) - I actually have two tabs open that keep track of two message boards I'm active on. One is private, and it gives me access to a group of friends I've engaged in casual discussions with for several years. Another is public, The Straight Dope Message Boards. If I run into a problem, I can ask a question in the General Questions forum and hundreds of exceptionally smart people, many of them experts on whatever topic I'm asking about, will stumble over one another to answer it. It's like answers.com but faster.
- Social News Sites (social, niche content) - I keep three tabs open on social news sites. My sites of choice are TotalFark, Digg and Reddit. Why? Because the links posted here show up in the mainstream press anywhere from a day to a week later. They're like incubators for the news stories that will eventually become part of the mainstream news consciousness. And you get bonus snarky headlines to boot. I have these tailored to pick up on stories that will interest me, like any percolating news about digital marketing, the economy or brand advertising.
- Facebook (social) - Some of my colleagues ask me why I put effort into Facebook at all. Two big reasons and a lot of little ones. The first is that if you're going to talk social to clients, you need to live social. The second is that I'm getting business out of it.
- LinkedIn (social) - Not nearly as cool as Facebook, but I'm still connecting with prospects and friends there. LinkedIn seems to be the social networking choice for brand marketers that would be potential clients for Underscore.
- Twitter (social) - I initially didn't think Twitter was important. Now I have a couple hundred people following me. Sometimes, your Twitter followers can help you solve problems that need immediate solutions. Like "I need a great intellectual property lawyer, like yesterday." or "Anyone know how to configure a RAID 0 array on a NAS device?"
- 14dayz (business application) - Web based timesheeting system. We just started using this, and it's great. Pick whatever you're working on from a list of projects and enter your time online. Or, just click a little icon next to a job and the system starts a timer. Click again and the timer stops and the time you just spent gets attributed to the job you specified. And it integrates well with other systems we're using.
- Sage RSS reader (niche content) - Okay, this is more of a Firefox extension than anything else, but it places all your RSS feeds in one place and you can use a browser tab to visit all the content headlines that you want to read. I have search feeds set up from blog search engines that will show up in Sage any time an indexed blog mentions our brand terms, so any time someone mentions "Hespos" or "Underscore Marketing" out there, I usually know about it withinin a couple minutes. We have similar search feeds set up for client brand terms. Sage also helps me follow what's going on with the various trade pubs.
- Various ad server reporting engines (business application) - Technically, I have to keep these open in Internet Explorer rather than Firefox (damn ActiveX controls...), but I can jump into campaigns at a moment's notice and see how they're serving out.
- comScore (business application) - Good for running a quick crosstab to see which sites have the lock on certain demographics or user groups.
- Netvibes (social, niche content) - Another web aggregator. I use it to aggregate content on a particular outdoor sport. This helps feed stories on a social network we're launching for the sport.
- FriendFeed (social) - Keeps track of many of the activities I engage in on the aforementioned social sites, lets my friends and associates know what I'm doing there, and gives me visibility into what they're doing socially.
I think it's interesting that over time, it's less about one-off visitation with these sites and applications. Their utility is constantly needed and/or constantly changing, so it's important to stay on top of them by checking in a few times a day.
No doubt a lot of people might find this particular arrangement of sites and applications to be dizzyingly confusing, but hey - it's different strokes for different folks. All of the things in these tabs support doing business smartly, quickly and efficiently.
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quote:That politician Gibson story was dismissed by the resident experts here a few weeks ago. The Gibson was named for that sniveling artist who drew the Gibson Girls -no two ways about it , so let's not hear any more apocrophal stories.
quote:Originally posted by GrampyI would love to include The Hour, but I have only seen quotes from it. It is my Holy Grail of Martini books. I've been seaching for it for years.
quote:Originally posted by seafarer johnI saw a man bounced out of a neighborhood bar in Poughkeepsie once, for ordering a "Johnny Walker and Coke"!
quote:Originally posted by GrampyUnlike the Martini, at least the actual history of the Stalini has been well-documented.
quote:Originally posted by dendanquote:Originally posted by GrampyUnlike the Martini, at least the actual history of the Stalini has been well-documented.Was there an actual reciept for it?
quote:Originally posted by seafarer johnI suggest we all send letters to our local papers and the food editors of national papers informing them of the Roadfood "Stalini " contest winner as a means of getting our name acceptedby those poor benighted souls who drink that swill. Also, we should petition Old Mr, Boston to change the name from "Kangaroo" to "Stalini". My letter to the boys and girls of the food section of the NYTimes will be in the mail by the weekend, as will a letter to the local press. Seafayer: I agree. the name should be immeidately solidified. I wil never order another one with the namePaul E. SmithKnoxville, TNIn order to get the editors attention ( a notoriously obtuse lot of dull mordant glob), I suggest use of phrases like, "International Roadfood . com", "15,000 members participated", "judging by three widely recognized gourmets (my guess is they collectively weigh about 900 pounds and have a collective belt of about 150 inches)", "poor little orphan bastard now has a name", "the sanctity of the Martini", etc, etc.
quote:Originally posted by cunamaraI like Bushmill's and prefer their Black Bush, an almost-single-malt of undeclared age. Any comments from Irish drinkers (Irish "mixers" pointedly excepted)?Tom
quote:Originally posted by clothier[Aqua Velva? You're kidding me, right?This is the joke post to seperate out the posers, isn't it?
quote:Originally posted by Rick F.quote:Originally posted by clothier[Aqua Velva? You're kidding me, right?This is the joke post to seperate out the posers, isn't it?+/-. Rumor had it that it could be drunk safely if it was filtered through bread. (Bearing in mind that this was believed at a small university in a "dry" county.) Nobody I knew had the nerve to try it, though. . . .


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Welcome to WebmasterWorld Guest from 188.8.131.52
Forum Moderators: open
I used to have a bookmarklet in my browser to make searches using ATW from the browser URL bar. Today I noticed it didn't work anymore and realized the following change has been made:
the "&query=" parameter transmitted to the server is now "&q="
Since Altavista and Alltheweb are about to merge, I suspect this is a move to unify the querries between the 2 search engines (Altavista also uses the &q parameter for searches).
Interestingly enough yahoo remains with its own syntax.
On the website, ATW hasn't yet updated the pages about their search tools (http://www.alltheweb.com/help/tools/index).
Do you know anything about that move? Am I making any mistake here?
For the record, here is now the typical ATW search string I use in my browser(s):


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BURBERRY, Celine, Mary Katrantzou and Temperly all graced the London Fashion Week runway, but only one show drew the likes of Kate Moss, Anna Wintour and Ellie Goulding all at once - Topshop Unique.
The unstoppable fashion chain unveiled its latest Unique collection for Spring Summer 2014, showcasing every trend you could possibly need to get you through the hottest season.
Billowing dresses in the colours of the earth, sun, sky and sea were paired with graphic prints, fringing, frills and panels. Anything bearing interesting embellishments are also a must this season, as seen on Cara Delevingne.
Silk, suede and lace are materials to watch out for come summer time, and demin blues are proving once again to be a fashion staple.
"Spring/Summer trends are all about dressing like you're on a holiday - think balmy beach days and dancing the night away in Ibiza wearing an embellished dress with metallic slide sandals," Topshop personal shopper Nikita Lindstrom told news.com.au.
"In Topshop's Unique SS14 collection you will see geometric patterns in hues of green and blue, and beautiful light fabrics - and you may even find yourself digging about in your cupboard for an old pair of plimsolls," she said.
SS14 beauty trends to have on your radar include nude lips, impact eyes and loose, natural hair.
"The look is dishevelled, decayed and sultry" Topshop beauty consultant Hannah Murray said backstage.
"We have used the new matte bronzer to sculpt the face and achieve that undone, lived-in, effortlessly cool Ibiza beach beauty."


text: Enzo Mari was born in Novara, Italy where he studied classics and literature at the Academia di Brera in Milan from 1952 to 1956. As a student, Mari supported himself by working as a visual artist and freelance researcher. In a period when Italian design was flourishing as enlightened industrialists collaborated closely with designers to rebuild their businesses, he also became interested in design and painstakingly taught himself about it. His first project for Danese was 16 Animali, or 16 Animals, launched in 1957.


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What Can We Learn From Deborah Shank?
The national media and the blogosphere are abuzz since the WSJ reported on the story of Deborah Shank. As explained by the Los Angeles Times:
Shank, a former overnight shelf-stocker for Wal-Mart in southeastern Missouri, was driving her minivan when she was broadsided by a semi and suffered permanent brain damage. Unable to walk without help, she lost the ability to care for herself or interact meaningfully with her family. Now 52, she lives in a nursing home.
Wal-Mart started out as one of the good guys in this story, paying almost $470,000 of her initial medical bills. But three years after Shank's husband sued and settled with the semi driver's employer, the retail giant changed hats. It demanded every penny back, plus interest and legal fees — more, in fact, than the $417,477 the settlement had placed in a special-needs Medicaid trust fund for Shank's future healthcare expenses.
Several things strike me about this story.
First, the WSJ incorrectly described Wal-Mart's cause of action against Ms. Shank as a subrogation claim. The WSJ stated:
In insurance circles, the recovery practice is called "subrogation." Employers and insurers say it's necessary to ensure that medical expenses aren't paid twice. By recovering those costs from someone who's been compensated elsewhere, they argue, they're saving money for everyone on the plan.
But this isn't classic subrogation. Subrogation is generally thought of as an insurer's right to step into the shoes of the party whom an insurer compensates and sue any party whom the insured could have sued. Wal-Mart isn't standing in the shoes of Ms. Shank and suing the trucker, which it almost certainly has the right to do. Wal-Mart is suing under a contractual provision which gives it a right to sue its insured for indemnification and eschewing its subrogatory rights.
Second, although Wal-Mart claims it needs this contractual right to prevent its insureds (the Deborah Shanks of the world) from double recovering, Wal-Mart is using this right to take easy money. That is, there is no evidence that Ms. Shank recovered twice. Ms. Shank likely had claims for pain and suffering, lost wages, loss of consoritum, etc. The settlement agreement could have stipulated that none of the money was going to pay her medical bills and Wal-Mart still would have had the right to sue her for indemnification. And Wal-Mart would have done so, because it is much easier to collect based on the clear contract language than in a subrogation lawsuit against the trucker. Think of it this way, presumably Ms. Shank settled for pennies on the dollar in her tort lawsuit, but Wal-Mart got nearly a full recovery from Ms. Shank. Why? Because Wal-Mart didn't have to establish the trucker's negligence or defeat the trucker's tort defenses as it would have if it had brought the subrogation claim.
Third, I wonder why Wal-Mart and other private insurers are doing this now, when the provisions apparently have been in the insurance contracts for years. One could speculate that private insurers feel emboldened to sue their insureds because Congress blessed this same practice for Medicare in 2003. As part of the same law that created the new Medicare prescription drug plan, Congress granted Medicare the right to recover its from beneficiaries who settle tort lawsuits.
Fourth, these indemnification lawsuits are justified as necessary to reduce the costs of medical insurance. But they might have an enormous impact on the civil and tort system. Injured parties have less incentive to bring and settle tort claims where they are forced to indemnify an insurer, because their expected recovery is much lower. This undermines the access function of the courts and the deterrence and corrective justice function of tort, not to mention undermines the social policy for health insurance. I wrote about these same issues (although in the Medicare context) in a forthcoming paper. Check it out.


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Almost four years from the start of the global financial crisis, the world economy remains fragile, and unemployment is unacceptably high.
There are about 200 million people unemployed worldwide, with nearly 75 million youth unemployed. Growth is weakening in a number of countries and uncertainty and risks have intensified, driven in particular by events in Europe.
The scale of the human cost tells us that a return to growth is urgently required.
When the G20 meets in Mexico on June 18-19, its challenge is to shift public expectations from a pessimistic mindset of ongoing crisis and concern about the future to an optimist mindset of growth and stability.
We need resolute action to address the uncertainty confronting the global economy and chart a path for strong, self-sustaining economic and jobs growth.
We see two elements to this.
First, the immediate concerns are with Europe and we need a clear message from Europe that it is taking decisive steps to stabilise and strengthen its banks and that it is focused on restoring growth while meeting the need for fiscal consolidation.
A crucial element of restoring confidence in Europe is agreement on a "road map" for the euro zone to underpin its monetary union by a fiscal union and a banking union, including pan-European supervision and deposit insurance.
It is essential that Europe moves quickly to ensure its banks are adequately capitalised and back-stopped. We welcome the decision by Spain to seek financial assistance from the euro group to recapitalise Spanish banks as required.
Decisive steps to ensure the health of the banking sector are not only necessary to reduce some of the risks that are preoccupying markets, but healthy financial institutions are vital for economic growth.
Europe must have credible fiscal consolidation plans to restore fiscal sustainability, but it is also essential that it has a strategy for growth that includes policies aimed at boosting investment, freeing-up product and labour markets, deregulating business, promoting competition and building skills.
These reforms, including deeper institutional integration, will be politically difficult and will take time before their full benefits are apparent, but setting a clear pathway will underpin public confidence in the sustainability of European growth and co-operation.
We do not underestimate the magnitude of the reforms that Europe has achieved in recent years.
Since the G20 met at Cannes, for example, Europe has increased its firewalls by €200 billion ($252 billion), restructured Greek debt, taken steps towards strengthening its banks and banking regulations, laid out rules for fiscal discipline, as well as implementing a range of employment and product market reforms.
But the magnitude of the challenges confronting Europe is such that far more decisive reforms are urgently required. We have confidence that Europe will act together to meet these challenges and we will continue to support Europe, because European stability and growth matter for us all.
Second, we need a clear message from the G20 that all its members are delivering policies for strong, sustainable and balanced growth.
To be meaningful, the message must be backed up with action.
G20 members must demonstrate that their policies are clearly directed at restoring economic growth and creating jobs, and that they will be accountable for meeting their commitments in full.
It also requires an unambiguous message from world leaders about resisting protectionism and opening trade and investment.
In particular, we think an early delivery on trade liberalisation by an international agreement on trade facilitation is the right step and would reduce the costs of trade and put momentum in trade liberalisation.
The G20 must demonstrate in Los Cabos that it is continuing the process of International Monetary Fund reform, including through countries delivering on the commitment to increase IMF resources by more than $US430 billion, and ensuring that the quota and governance structure of the IMF reflects the shifts in economic influence that have been taking place over the past decade and will continue in the future.
Economic growth and new jobs are crucial to improving people's livelihoods both now and for future generations. The reforms to secure these objectives are not easy and change will not happen overnight, but the world is expecting the G20 to deliver.
The Australian Financial Review


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Hartzell Propeller's parent company, Tailwind Technologies, has purchased the assets of Kelly Aerospace Energy Systems of Montgomery, Ala., for an undisclosed amount. According to Joe Brown, group president of Tailwind Technologies, the company's newest division has been renamed Hartzell Engine Technologies and will remain in Montgomery. Mike Disbrow, senior vice president of sales, marketing and customer support at Hartzell Propeller, will lead the new division. Disbrow has more than 20 years' experience in the general aviation industry. "The acquisition of the Energy Systems assets of Kelly Aerospace continues our growth strategy through the formation of a new business with a broad suite of engine and aircraft accessories," Brown told AIN. Hartzell Engine Technologies' product line will include turbocharger systems, alternators, starters, Janitrol heaters, fuel pumps, oil filters, ignition harnesses, magnetos, voltage regulators and MCUs and a large range of other electrical components, primarily serving piston-engine general aviation and military aircraft, as well as piston- and turbine-powered helicopters.
Tailwind Buys Kelly Aerospace Energy Systems' Assets
- October 6, 2010, 12:58 PM


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NeoCrumb, LLC
Orlando, FL 32810, US
NeoCrumb, LLC was formed to promote a new family of products for the plastics industry. Using a proprietary process, we are able to bond rubber from recycled tires with virgin/recycled plastic to create an entirely new composite compound.
Please view our EquityNet 'Entrepreneur Spotlight' here: https://www.equitynet.com/blog/entrepreneur-spotlight-sam-tamiz-lawrence-deneault/
NeoCrumb has developed an innovative product that can change the face of the plastics industry. Called PolyCrumb, the product is a replacement for virgin resin used in plastic extrusion and injection molding machinery, but with far broader application and versatility.
Current plastic extruders and injection molders contend with tight margins, in the region of 5 – 7%. Because of PolyCrumb's unique characteristics, its application in the production process can result in immediate and significant cost savings, resulting in increased profit margins of 25% to 50%. Reasons include:
– Injection molded at lower temperatures
– Less shrinkage and faster cooling times of the end product
– The price of PolyCrumb is lower than virgin resin
We make PolyCrumb using a proprietary process that mixes rubber from scrap tires with various polymers, whether virgin or recycled, to create an entirely new composite compound. The product comes in the form of granular pellets and has applications as both a polymer and an elastomer.
PolyCrumb demonstrates environmental responsibility. Scrap tires continue to pose a serious environmental headache, as a lack of a cost-effective industrial application results in millions of scrap tires being dumped in landfills across America.
To date, we have tested the product, proven the ability to manufacture at any given quantity, and made initial presentations to customers. Customers have shown incredible enthusiasm for PolyCrumb, and their feedback has been essential to optimizing our product offering. This has resulted in an initial basket of around 20 PolyCrumb products, each with slight variations to meet differing needs.
Our reason for this round of fundraising is to execute an almost vertical sales growth. Based on current indications, we could be at a $12 million run rate by year-end.
Products / Services
PolyCrumb is made using an innovative and proprietary process that mixes tire-derived crumb rubber with various polymers, whether virgin or recycled, to create an entirely new family of composite compounds. PolyCrumb possesses the characteristics of virgin resin, but with far broader application and versatility. PolyCrumb comes in the form of granular pellets – similar to existing products used in plastic extrusion and injection molding machinery – and has multiple applications in the plastics industry.
Some of the key benefits of using PolyCrumb in the manufacturing process include:
– Injection mold at lower temperatures
– Increased throughput
– Reduced lead times
– Create stronger and less brittle products
– Can be made from 100% recycled materials
The unique characteristic of PolyCrumb is that it has applications as both a polymer and an elastomer, giving us and our customers total flexibility.
Director Finance
Lawrence Deneault
Lawrence has been in the financial services industry for over 30 years. During the 1980s, he managed a financial services firm in Los Angeles, where he developed a series of financial products to help manufacturers of capital goods and high technology products get their goods to market. In 1990, Lawrence represented a client to oversee the financing and development of the first major cable television network in Turkey. From there, he worked on various landline and cellular telecoms projects throughout Central Europe. In the mid 1990s, Lawrence moved into the equity markets and established an institutional brokerage firm in London and New York, to service some of the largest institutions in Europe. The firm was sold in 2003 to a publicly-held firm in Sweden. Lawrence brings to NeoCrumb extensive knowledge of the financial markets. He has been responsible for funding the company and structuring its financial operations.
Director Manufacturing/Production
Robert Salveson
Robert (Bob) has 30 years of experience in corporate controllership positions; CPA firm management for a 65 person firm specializing in auditing private and public entities; and mergers & acquisitions, strategic business planning, taxation, and financial and organizational management. Bob's experience extends past the aforementioned as he has evaluated prospective emerging growth and microcap companies for potential investors while filling various managerial roles such as President, CEO, or CFO. He has been President and COO of a soft gel encapsulation firm that ran 24/7, a controller and cost accountant for a building materials manufacturing during its startup phase and is therefore familiar with manufacturing processes and procedures. He graduated from the University of Florida with a B.S. degree with a major in accounting.
Director Business Development
Dan Dorey
Dan has extensive experience in the development of new business opportunities for startup enterprises, as well as for those looking to re-invigorate their business strategies. Dan's strengths lie in using his in-depth knowledge of markets to optimize sales strategies. Through a mixture of training programs, reorganization of distribution networks, and improved communications with clients, he has successfully helped companies increase their sales, refine their product offerings, and streamline their overall approach to sales and marketing. Dan brings to NeoCrumb particular expertise in the fields of sales and marketing, having already developed strong links within the plastics industry from previous experience. Leveraging his knowledge and experience, Dan has been responsible for sourcing much of the sales opportunities currently available to NeoCrumb.


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A council is to exhume the body of a woman buried in the wrong grave for seven years. Irene Cheevers said she was "gobsmacked" when she was visited by Cookstown District Council (England) officials on the anniversary of her aunt's death and was told she had been interred in the wrong plot.
Ina Cheevers died, aged 83, on January 17, 2003 and for seven years her niece and next-of-kin, Irene, had been tending the grave in the council-run cemetery on Westland Road. She had erected a small plaque with her aunt's name engraved on it as a memorial to her.
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Fashion Resume: Sky Ferreira
Whether worn in 1920 or 2013, this timeless orange organza dress is guaranteed to turn heads, no matter the era.
This green gown — embroidered with pearls, stones, and sequins — is the absolute epitome of that 1920s decadence.
The 10 Most Gorgeous Gowns from the Spring 2014 Bridal Shows


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Rane Sixty Two Z Special Edition DJ Mixer
Turntablism is alive and more creative than ever. Rane and Serato are proud to be supporting partners in that creativity with the introduction of the Rane Sixty-Two Mixer for Serato Scratch Live. For more than a decade, artists have chosen innovative Rane instruments to advance their art and three generations of TTM series mixers have been the top pick for many of the world's best performers.
Main Features
- Full-featured mixer and DJ software package
- Take your skills to the digital realm with Serato Scratch Live
- Flexible I/O let you use both analogue and digital audio
- Limited Edition Z-Trip with Purple and Yellow highlights
- Includes custom high-grade purple cables by Oyaide for Rane
- Read More
The Sixty-Two is a plug-and-play package supporting two computers, two-deck digital vinyl simulation, SP-6 sample player, software and hardware effects and all the record and playback channels you need. Software controls for Library, Loops, Cues and SP-6 are laid out for fast and intuitive access. Choose the Sixty-Two and join a community of users dedicated to advancement of the art.
The Sixty-Two Mixer supports both analogueue and Digital Vinyl Simulation (DVS) playback. The mixer is bundled with Serato Scratch Live and includes a fully integrated MIDI controller for software controls.
A typical setup includes operation with two Scratch Live DVS channels, SP-6 sample player on an independent USB Aux playback channel and Software effects enabled on the USB digital insert in the FlexFx loop. This setup also allows recording PGM1 post-fader, PGM2 post-fader and the Main mix.
Front and Rear Panels
The Headphone output is available on both 1/4 inch and 3.5 mm TRS jacks.
Cueing can pan between Cue & Main Mix, or Split Cue operation.
PGM Inputs 1-4
The Sixty-Two has four stereo analogue inputs for PGM 1 through PGM 4. Any of these analogue inputs may be set for Phono or Line Input using the PH - CD switches. Any of the four analogue inputs may be used for Scratch Live vinyl emulation control. Input 1 or Input 2 may be selected for Scratch Live Virtual Deck 1 control. Input 3 or 4 may be selected for Scratch Live Virtual Deck 2 control. Control input sources are selected in Scratch Live.
Mic Input
The Mic Input accepts an XLR or a balanced or unbalanced 1/4 inch plug. The Mic has a switchable line level option to connect a wireless receiver.
Analogue Outputs
All analogue outputs come from the same 'Main Mix' signal. Main and Session outputs each have their own Level control. The Main output is on balanced 1/4 inch TRS (tip-ring-sleeve) jacks, though unbalanced TS (tip-sleeve) plugs may be used. The Session output is on regular unbalanced RCA jacks. Because all signals are identical, users may use any of these outputs as the 'main' output if a different cable type is required for connection.
Serato Scratch Live
Easily import your playlists and iTunes library. You can drag from Explorer (Windows) or the Finder (Mac) into the Scratch Live library. The crate and subcrate system helps organise your library and sets. Hot-swap external drives with fast automatic library merging and retention of crates. Browse your music collection by album, artist, BPM, or genre, with optional album art display. Intuitive search function can be applied to any field to find things quickly. Edit ID3 tags with full Unicode support.
Preprocessing of MP3 files is not required except to detect corrupt files or use the auto-BPM and auto-gain functions. Auto-BPM detects tempo information for tracks without it, saving it with each file. A tap tempo button allows you to enter your own. Auto-gain lets you set a target gain on any or all songs in your library. You can also manually adjust individual gain, remembered in each song file.
Scratch Live supports all these file formats: Fixed and Variable Bit Rate MP3, MP4, AIFF, AAC, ALAC, WAV, OGG Vorbis, CD Audio and direct from the mixer. Record from your mixer's Aux output and immediately scratch as if it was on vinyl. Record direct from vinyl or CD and save as a 24-bit 48 kHz or 96 kHz stereo file.
The Virtual Deck shows everything about the speed and position of a track. As the vinyl rotates, so does the line on the label. The circular progress bar around the edge is a visual representation of the position within the song. The time and remaining time are displayed in minutes and seconds. The turntable speed as a percentage of pitch shift is on the left, and the pitched BPM is on the right.
Different operating modes can be assigned to each Virtual Deck:
Absolute Mode — exact reproduction of record movement, needle drop through tracks – just like normal vinyl. The beginning of the track is mapped to the start of the record.
Relative Mode — skip-free scratching, jump to cue points, and pitch bend buttons combined with turntable control. This mode observes the relative forward and backward movement of the record, but does not regard the position within the record.
Internal Mode — mix with just your laptop using features modelled on DJ CD players. Rewind, Bend down, Play / pause reverse, Play / pause forward, Bend up, Fast forward.
Auto mode — play a sequence of tracks automatically.
With Key Lock on, the key or pitch of the song stays locked at what it would be if the track was playing at normal speed, regardless of the platter speed of the turntable or CD player. Key Lock has scratch detection, so it automatically turns off when scratching for a natural scratching sound.
Variable zoom waveforms centred around current position display horizontally or vertically. Waveforms are coloured by frequency so you can distinguish instruments visually. Full track overview lets you quickly find where the beat drops, find breakdowns and choruses, and jump to any part of the song. The tempo display assists with rapid tempo matching of tracks. When the two tracks are matched to the same tempo, the peaks will line up. Beat display emphasises the transients in tracks -- these are matched up when the two tracks are beat matched. Visual markers can be set for up to 5 cue points per song and triggered from the keyboard. Save up to 9 loops per track -- these loops are saved in the file, and will be present when you reload. Censor expletives on the fly with an instant quick-reverse and catch-up with no loss of timing or pitch.
System Requirements
• Intel 1.83 GHz Core Duo or better.
• OSX 10.5.8 or higher.
• Available 2.0 USB port.
• 1024 x 768 screen resolution.
• 5400 RPM hard drive. 7200 RPM for high-resolution audio playback.
• 2 GB RAM (a large library will like more RAM).
• Intel processor, 2.2 GHz Core Duo or better.
• Windows XP with Service Pack 3 or higher.
• Windows Vista with Service Pack 2 or higher.
• Windows 7, recommended over Vista.
• Available 2.0 USB port.
• 1024 x 768 screen resolution.
• 5400 RPM hard drive. 7200 RPM for high-resolution audio playback.
• 2 GB RAM (a large library will like more RAM).
- This product will be ordered in from our suppliers as required. Please contact us for availability.
This item is normally sent to Mainland UK addresses by DPD who generally provide a one-hour window of delivery on the morning of delivery by email or text message. If you need this item faster, please upgrade to a Before 12 service at checkout.
FREE delivery within mainland UK
UK Non-Mainland: £ 12
Rep. of Ireland and Mainland Europe: from £ 15 (calculated at checkout).
Order this item before 4pm and receive it on the next working day, mainland UK only*
1 Recommended Accessory
Additional Information
Brand Rane Condition New
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731111 10680443531
In Stock!
Simply Suspects is a game of suspicion and betrayal. In this game, each player gets the chance to play a suspect of a crime. Each suspect has the opportunity to tamper with the evidence so it points to another suspect–but be careful, if the evidence points to you when you reach the Grand Jury, you'll be eliminated from the game! Simply Suspects offers lots of opportunities for players to be creative and think quickly. The fast pace of this game will keep kids and adults alike thrilled! 2 to 6 players.
For ages 8 and up.
• Fun, suspenseful board game
• Each player is a suspect of a crime
• Tamper with the evidence to point to other suspects
• Avoid accusation by the Grand Jury
• Fast-paced game that encourages creativity
• 2 to 6 players
731112 In Stock!
316 - Board Games -
375 - Games, ages 9-12 - Games
382 - Games, ages 12+ - Games
389 - Gifts $15-$25 -
393 - Boys Gifts -
394 - Girls Gifts -
657 - Shop All Ages 9-12 -
658 - Shop All Ages 12 and up - 12+ years old
936 - 9 years old -
937 - 10 years old -
Delivery time estimates do not apply to personalized, large or heavy items (over 20lbs.) that require special shipping, items shipped directly from the manufacturer, or out-of-stock items.
Delivery estimates only apply to the contiguous United States. Saturday, Sunday and national holidays are not considered business days for these estimated transit days.