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Stereotactic Radiosurgery After Surgery in Treating Patients With Brain Metastases
This study has been terminated.
(Early analysis indicated SRS not as beneficial post-op as pre-op)
Duke University
National Cancer Institute (NCI)
Information provided by (Responsible Party):
Duke University
ClinicalTrials.gov Identifier:
First received: December 23, 2008
Last updated: August 4, 2014
Last verified: May 2013
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
Detailed Description:
RATIONALE: Stereotactic radiosurgery may be able to send x-rays directly to the tumor and cause less damage to normal tissue. Giving stereotactic radiosurgery after surgery may kill any tumor cells that remain after surgery.
PURPOSE: This phase II trial is studying how well stereotactic radiosurgery works in treating patients with brain metastases.
|Metastatic Cancer Unspecified Adult Solid Tumor, Protocol Specific
|Behavioral: MMSE Behavioral: QOL via FACT-Br Procedure: MRI Radiation: Post-operative SRS
|Phase 2
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Phase II Single-arm Study of Post-operative Stereotactic Radiosurgery for Brain Metastases.
Further study details as provided by Duke University:
Primary Outcome Measures:
- Recurrence Rate at the Surgical Site as Measured by MRI [ Time Frame: 12 months ]The number of months for local recurrence via MRI
Secondary Outcome Measures:
- Rate of Salvage Whole-brain Radiotherapy, Stereotactic Radiosurgery (SRS), or Surgery [ Time Frame: 12 months ]
- Rate of New Brain Metastases Outside of the Adjuvant SRS Site [ Time Frame: 12 months ]
- Quality of Life as Measured by the FACT-Br Subscales [ Time Frame: Every 3 months for 12 months ]
- Preservation of Neurocognitive Function as Measured by the Mini-Mental State Exam [ Time Frame: Every 3 months for 12 months. ]
- Clinical Significance (if Any) of Locally Recurrent Brain Metastasis at the Time of Their Occurrence (Mass Effect, Cognitive Functioning, and Other Symptoms) [ Time Frame: 12 months ]
- Rate of Death Due to Neurologic Causes [ Time Frame: 12 months ]
- Overall Survival [ Time Frame: 12 months ]
|Study Start Date:
|August 2008
|Study Completion Date:
|June 2009
|Primary Completion Date:
|June 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Active Comparator: Post-operative SRS
All patients will undergo SRS with the planned target volume (PTV) defined as the resection cavity plus a 3-mm margin after surgical resection of a single brain metastasis. Dose will be prescribed to the maximum isodose line completely encompassing the PTV using the guidelines established in RTOG 9005. All patients will be evaluated for neurocognitive function via Mini-Mental State Examination (MMSE), Quality of Life (QOL) via FACT-Br, and for local recurrence via MRI every 3 months over the course of the study.
Behavioral: MMSE
Neurocognitive function via MMSE done every 3 months for length of study.
Other Name: Mini-Mental Status ExamBehavioral: QOL via FACT-Br
Quality of Life via FACT-BR every 3 months for length of study.
Other Names:Procedure: MRI
MRI done every 3 months for the length of the study.
Other Name: Magnetic Resonance ImagineRadiation: Post-operative SRS
Single fraction SRS is currently a viable treatment option of intracranial metastatic lesions.
Other Name: SRS
Detailed Description:
- To estimate the rate of recurrence at the surgical site in patients with brain metastases treated with adjuvant stereotactic radiosurgery (SRS) compared with historical data documenting recurrence at the surgical site after surgery and whole brain radiotherapy (WBRT).
- To estimate the rate of salvage WBRT, SRS, or surgery in patients treated with adjuvant SRS alone.
- To estimate the rate of new brain metastases outside of the adjuvant SRS site.
- To estimate patient quality of life after adjuvant SRS alone.
- To assess the effect of surgical intervention and SRS on the preservation of neurocognitive functioning in these patients.
- To determine the clinical significance (if any) of locally recurrent brain metastases at the time of their occurrence (mass effect, cognitive functioning, and other symptoms) in these patients.
- To estimate the rate of death due to neurologic causes, defined as death attributable to the progression of neurological disease.
- To estimate the overall survival of these patients.
OUTLINE: Patients undergo stereotactic radiosurgery over 30-90 minutes.
Quality of life and neurocognitive function are assessed periodically.
After completion of study therapy, patients are followed every 3 months for 1 year and then every 6 months for 1 year.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Age >18 years of age.
- Gross total resection (as verified by the lack of any enhancement in the resection cavity on post-operative MRI) of single brain metastasis confirmed by histology. Patients with up to 4 metastases are eligible if the largest mass is amenable to surgical resection and all non-resected masses are amenable to SRS.
- Patient must be Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA) Class 1 or 2.
- Life expectancy of at least 3 months.
Exclusion Criteria:
- Radiographic or cytologic evidence of leptomeningeal disease.
- Patient with incomplete or partial resection.
- Primary lesion with radiosensitive histology (i.e., small cell carcinoma, germ-cell tumors, lymphoma, leukemia, and multiple myeloma).
- Patients with a resection cavity > 4 cm in maximal extent in any plane on contrasted MRI scan.
- Lesion located in anatomic regions which are not amenable to SRS including the brain stem and optic apparatus.
- Pregnant or need to breast feed during the study period.
- Uncontrolled intercurrent illness including, but not limited to symptomatic congestive heart failure, unstable angina pectoris, or psychiatric illness.
- Brain surgery other than for resection of metastasis.
- Previous brain radiotherapy.
- Contraindication to SRS, WBRT, or MRI.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00814463
Please refer to this study by its ClinicalTrials.gov identifier: NCT00814463
|United States, North Carolina
|Duke Comprehensive Cancer Center
|Durham, North Carolina, United States, 27710
Sponsors and Collaborators
Duke University
National Cancer Institute (NCI)
|Principal Investigator:
|John H. Sampson, MD, PhD
|Duke University
|Principal Investigator:
|Hamidreza Aliabadi, MD
|Duke University
|Principal Investigator:
|John P. Kirkpatrick, MD
|Duke University
|Principal Investigator:
|James E. Herndon, PhD
|Duke University
More Information
Keywords provided by Duke University:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 20, 2017
|Responsible Party:
|Duke University
|ClinicalTrials.gov Identifier:
|NCT00814463 History of Changes
|Other Study ID Numbers:
DUMC-PRO00004373 ( Other Identifier: DUHS IRB )
|Study First Received:
|December 23, 2008
|Results First Received:
|January 23, 2013
|Last Updated:
|August 4, 2014
Keywords provided by Duke University:
tumors metastatic to brain
unspecified adult solid tumor, protocol specific
Additional relevant MeSH terms:
Neoplasm Metastasis
Neoplastic Processes
Pathologic Processes
ClinicalTrials.gov processed this record on September 20, 2017


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A Funky Thing Happened on the Way to the ParkRick Hirsch - Hirsch Music
You can never have too many groovy, funky charts in your combo book, right? This was originally written to feature Steve Wiest with the University of Illinois Jazz Bones. It features your choice of a trombone, trumpet or sax soloist with four trombones and rhythm section.
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text:
Shalom serves as Principal of The Vela Group, VP at Midwestern Career College and Director of Marketing at Certified Health Management. As Vice President, Shalom Klein has grown, managed and developed Moshe Klein, & Associates and MKA Receivables. Shalom oversees a staff of more than 10 associates and the operations of three offices, as well as handling client relationships and consulting opportunities. Shalom also oversees a college and career program at Fasman Yeshiva High School, Hanna Sachs Bais Yaakov and Lubavitch Girls High School.
As Founder of Jewish B2B Networking and Jewish Business News, Shalom Klein saw a need in the small business and Jewish communities and created the vision for what is now the premiere business and employment networking organization across the Midwest. Shalom plans and runs events, oversees volunteers, meets with members / participants, and consults with other organizations in how to plan similar resources. Shalom also was engaged in December 2013 to become the Executive Director of the Jewish Community Council of West Rogers Park, leading marketing and economic development efforts in the Chicago community, which includes Devon Avenue.
Shalom has been the recipient of Keshet's 2013 Community Service Award, the ATT's Young Leadership Award, multiple proclamations from the Illinois General Assembly, Senate, City of Chicago and the Villages of Lincolnwood, Evanston, and Skokie. Shalom earned his Certificate in Jewish Leadership from Northwestern University and Master of Arts degree in Jewish Professional Studies with a concentration in non-profit management along with a Certificate in Jewish Arts Education from Spertus Institute. Shalom is a bone marrow donor and received honorary initiation from the Alpha Epsilon Pi fraternity, and has been named "Jewish Community Hero" by Jewish Federations of North America and listed as one of the "36 under 36" by the Jewish United Fund. Shalom's work has been discussed twice on the floor of the United States Congress.
Shalom is also involved in the following community organizations and initiatives:
Chairman, Economic Development Commission – Village of Skokie
Vice Chairman, Professional Leadership Board – Keshet
Founder and Steering Committee Member – Dempster Street Merchants Association
Co-Chairman – Chicago Yachad
Communications and Government Affairs Committees – Jewish United Fund / Jewish Federation
Board of Directors – Skokie Caucus Party
Small Business Advisory Board – United States Senator Mark Kirk's Office
Job Creation Advisory Board – Illinois State Treasurer's Office
Advisory Board Member – ORT Technical Institute


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It's become something of a cliché, but Springbok coach Heyneke Meyer has picked a good mix of youth and experience for this year's Rugby Championship, showing faith in those who've been in the business for years, but also handing invitations to some promising youngsters.
Veteran performers Victor Matfield, Bakkies Botha, Bryan Habana and Ruan Pienaar are still in the Bok fold and in line to feature at next year's World Cup. But Meyer has also backed Teboho Mohoje, Lood de Jager, Damian de Allende, Jan Serfontein, Handré Pollard and now also Cobus Reinach.
De Allende returns to the squad, along with captain Jean de Villiers, Eben Etzebeth, Frans Malherbe and Pat Lambie, after missing out in June because of a knee injury.
Scrumhalf Reinach's call-up is just reward for an outstanding Super Rugby season. He gets his chance following the unavailability of Fourie du Preez, who'll miss the rest of the year through injury. Reinach follows in the footsteps of his late father, Jaco, who also donned the Bok jersey in the 1980s and early 90s. He'll be the back-up to Pienaar and Francois Hougaard.
Schalk Burger, along with JP Pietersen – both of whom are playing club rugby in Japan – will only be available for selection later in the competition.
The other position, besides scrumhalf, which has caused a few headaches of late, that of third choice hooker, is filled by veteran No 2 Schalk Brits.
The most glaring omission from the squad is prop Coenie Oosthuizen, who up to the June Tests was backed by Meyer to be Jannie du Plessis' back-up as tighthead prop. The Cheetahs man has, however, failed to convert successfully from the loosehead side of the scrum and will now be given time in the Currie Cup to hone his skills as a No 3. Malherbe will be the second choice tighthead in the coming weeks.
Meyer said it was great having De Villiers back in the squad.
"Victor (as captain) and Jan Serfontein (as inside centre) both did superbly well in his absence, but Jean is our captain and I'm sure he will slot back into the side without any difficulty.
The same goes for Eben, Frans and Patrick, all of whom have been part of the squad before.
"We will assess the fitness levels of all the players in the squad in Johannesburg this week. This will not only include the players who missed the June Tests because of injury, but also someone like Beast Mtawarira, who has been out of action for a while. We will deal with every player and his needs individually."
Meyer said he was looking forward to the Rugby Championship, which kicks off next Saturday when Australia host New Zealand in Sydney and the Springboks take on Argentina at Loftus Versfeld in Pretoria (kick-off 5pm).
The Springbok squad will gather in Johannesburg for a pre-competition camp from Monday to Friday this week and then again the following week in Pretoria, where they will prepare for the Test against Argentina.
"We've been steadily improving over the past two years, but another step-up is needed this season," said Meyer. "It's been a theme for us since the start of the season and we must simply keep on accelerating in the coming two months. We've set ourselves some goals for the Rugby Championship and we'll have to be focused and switched on from the moment we get together in Johannesburg."
Forwards: Duane Vermeulen, Willem Alberts, Marcell Coetzee, Teboho Mohoje, Francois Louw, Victor Matfield, Lood de Jager, Bakkies Botha, Eben Etzebeth, Jannie du Plessis, Frans Malherbe, Beast Mtawarira, Trevor Nyakane, Gurthro Steenkamp, Bismarck du Plessis, Adriaan Strauss, Schalk Brits
Backs: Willie le Roux, Pat Lambie, Lwazi Mvovo, Bryan Habana, Cornal Hendricks, Damian de Allende, Jean de Villiers (capt), Jan Serfontein, Morné Steyn, Handré Pollard, Ruan Pienaar, Francois Hougaard, Cobus Reinach
Not considered (injuries): Flip van der Merwe, Pieter-Steph du Toit, Arno Botha, Pierre Spies, Jaque Fourie, Fourie du Preez
In Japan (to be considered later): JP Pietersen and Schalk Burger
August 16: Australia v New Zealand, 12.05pm; South Africa v Argentina, 5pm
August 23: New Zealand v Australia, 9.35am; Argentina v South Africa, 9.40pm
September 6: New Zealand v Argentina, 9.35am; Australia v South Africa, 12.05pm
September 13: New Zealand v South Africa, 9.35am; Australia v Argentina, 12.05pm
September 27: South Africa v Australia, 5pm; Argentina v New Zealand, 9.10pm
October 4: South Africa v New Zealand, 5pm; Argentina v Australia, 9.10pm - Sunday Independent


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MTYP ready to send parents to penalty box
HOCKEY'S back... even at Manitoba Theatre for Young People. In time for the end of the National Hockey League lockout, the kids' theatre has revived one of its top-scoring shows, The Big League by Winnipeg actor/playwright James Durham, for a mainstage run through Jan. 26 followed by a Manitoba tour set to play to more than 27,000 students before the end of April.
Its premiere production in 2005 lasted a then-record 86 performances at MTYP and drew a lot of attention to the scourge of minor-league hockey: parental rink rage. The topical subject matter has drawn interest from theatres throughout the country, especially in Vancouver, where the play has been staged four times, as well as across the Prairies to London and Toronto
The Big League invites youngsters into arena stands to watch 12-year-old Tommy try out for a triple-A hockey team while stickhandling around his dad's increasing pressure to succeed at all costs. It looks at a continuing social problem of parents who forget hockey is just as game and lose track about what's important when they heckle referees, berate coaches or scold the players.
"Everyone knows or remembers a parent who would come to the rink and just scream," says Ron Jenkins, back to direct The Big League again.
Jenkins, a frequent MTYP helmsman, was hardly a teen when his hockey games were marred by a teammate's dad showing up drunk and belligerent, loudly chastising his son. It continued until the coach had the parent banned from the rink.
"As a kid, you really don't know what to say," says Jenkins, who directed another hockey drama called Playing with Fire: The Theo Fleury Story for Calgary's Alberta Theatre Projects last May. "I know it was humiliating for the kid."
If some children see their painful reality captured on stage, so did moms and dads who have recognized themselves and were grateful for having their eyes opened about their rinkside behaviour, says Jenkins, a former Winnipegger who lives in Edmonton.
The Big League's audience sits in stands flanking Leanne Foley's representation of a neighbourhood rink on which the cast of Tiffany Ayalik, Raes Calvert, Brent Gill and Corey Wojcik whirl around on in-line skates. It is presented like an hour-long hockey game, with three periods that reflect the emotional state Tommy and his father are experiencing, before they go into sudden-death overtime.
Get in the game at MTYP today and Sunday at 1 and 4 p.m. as well as Jan. 25 at 7:30 p.m. and again at 1 and 4 p.m. on Jan. 26 Tickets are $15.50 plus GST and are available by calling 204942-8898 or atwww.mtyp.ca
One show that shouldn't be overlooked during one of the busiest times of the Winnipeg stage season is the long overdue debut of Martin McDonagh's savagely dark comedy, The Cripple of Inishmaan.
Anyone who remembers the bleakly funny The Beauty Queen of Leenane or The Lonesome West knows that McDonagh always shocks and entertains. The violence and profane dialogue of his scripts has earned him a well-deserved reputation as the Irish Quentin Tarantino of the stage.
The University of Manitoba students in the Black Hole Theatre are presenting Cripple, the story about the monotony on the isolated island of Inishmaan that is broken when a film crew arrives nearby. Everyone including "Cripple" Billy Claven, want into the movie to escape the boredom.
"McDonagh has said he wants people to leave his plays feeling like they just came out of a rock concert," says director Mike Long, a fourth-year theatre student. "He writes with no regard for the production, about how anyone can stage his plays."
In The Lieutenant of Inishmore, that meant scattering the stage with blood and body parts. Every performance of The Lonesome West features the frenzied destruction of about 100 religious statues and figurines.
"In The Cripple of Inishmaan some- one gets four eggs smashed on them in two minutes," says Long, 25. "It's a dream when you are reading it but then you have to figure out how to do it."
The 1997 Irish yarn has been in the news recently because Harry Potter star Daniel Radcliffe will play the title character in London's West End next June.
Cripple will be presented tonight at 8 p.m. at the Black Hole Theatre, lower level of University College, and also Jan. 23-26. Showtime is 7 p.m. next Tuesday. Tickets are $15, $12 for students and seniors and can be reserved by calling 204-474-6880 or purchased at the door.
The Big League examines the problem of parents who forget hockey is just a game and heckle referees, berate coaches and scold players.


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"You're always thinking - will I ever have a child?"
After going through three very difficult pregnancies, twice miscarrying at 17 and a half weeks and once more at the 18-week mark, Lisa began to wonder if she'd ever have a child.
She shares her experience of her fourth pregnancy, and the support, care and funding that she received from Tommy's and Dr. Andy Shennan, in the video below.
With the help of Tommy's and the staff at St. Thomas, Lisa successfully carried her pregnancy to full-term, and gave birth to two healthy baby girls, twin daughters Holly and Ella. Lisa says, "Without him [Andy], and the funding from Tommy's, I really do believe that I wouldn't have these twins here today."
"It's not just the funding side – it's the emotional. They gave us support, and we are truly grateful to them for all the help they've given us."


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Mental Health
Have Mental Health Questions? Ask a Psychiatrist Online
I believe I can help you with your concern
Give me a minute to read over your question, so that I can best serve you tonight.
May I ask, when did this behavior start?
And have you ever sought out psychological counseling for this behavior?
To varying degrees for the last 6 or 7 years. But feels more out of control now than it has before. I have sought psych help before but not for this behaviour
Well the typically the behavior of binge eating is related to a depressive disorder and eating is your way of "comfort," but that is usually short lasting, which i am sure you can attest to. Also binge eating can be used to punish ones self as well, usually this occurs if a person has a lot of self-blame.
I went through some serious acid reflux in my 11th grade, to the point where I was basically involuntarily anorexic, couldn't keep food down. I think it started about a year after that cleared up. The acid reflux was stress realted
"Also binge eating can be used to punish ones self as well, usually this occurs if a person has a lot of self-blame." This is what it feels like, but it feels so generalized, that I can't figure out why the hell I'm doing it so I can get to the root cause.
Okay, and do you believe that you have any symptoms of depression possibly (e.g. low self-confidence, crying spells, chronic sadness, difficulty concentrating, etc...)?
All of the above
I also have a hypoactive thyroid which I guess is commonly linked to depression
Well it could be a mix of depression and anxiety, these two disorders frequently combine and can result in a binge eating disorder. The punishing one's self is usually related self-blame and low self-confidence, all symptoms of depression
Yes hypothyroidism, i have it too, also can lead to depressive symptoms as well. Are you taking medication for this?
Okay that is good, that is what I take as well
I have these crazy mood swings which usually cooincide with binge eating. But I've had every test that exists for thyroid function and tried adjusting dosages and it seems like i'm on the right dosage.
Most likely you are on the right dosage and your depression/anxiety are separate from your thyroid function
I think the first step you should take is to find a therapist that specializes in eating disorders, I can help you find one if you like
that would be great
What is your zip code so I can look in your area
Okay give me a few minutes to look in your area for you.
Okay so all of these therapists specialize in treating eating disorders and most of them also specialize using Cognitive Behavioral Therapy (CBT) which is considered the best therapy modality for treating binge eating like you described
Also I would like to recommend these great treatment books that use CBT principles as well to help you too
In addition, this is a good link to that helps to link low self-esteem and eating disorders too. It provided great treatment techniques too
In addition, if you are considering using an antidepressant I would recommend Wellbutrin as this can be effective for depressive/anxiety symptoms and actually promotes weight loss as well
Ok, thank you
Is there anything else I can help you with tonight?
I just looked up wellbutrin and it's not recommended for people with eating disorders. I assume they are refering to eating disorders where you deprive your body of food?
Yes usually it is not recommended for individuals with anorexia and bulimia. Since binge eating has effected your health, I did not want to recommend an antidepressant that can actually cause you to gain more weight, which can further depression in some people.
For binge eating it is usually okay to use, but this is up to your general practitioner or a psychiatrist, which ever you choose to seek
Do you have any other questions or concerns that I can help you with?
The specialists you recomended are therapists yes? So they are not in the business of prescribing drugs? (just to clarify)
No, they do not provide medications, they just give therapy. Would you like me to try to find psychiatrists in your are that specialize in eating disorders too? Usually most psychiatrists these days do not provide therapy as often as a psychologist, this is why I only recommended psychologists to you, but I would be happy to try to find a psychiatrist in your area too. Most individuals typically see a psychologist for therapy (once a week on average) and a psychiatrist for medication management (1 every 3 months on average).
k, that's fine. I'll start with this.
I spend too much time reaching out for easy answers: tarrot cards and psychics and shitty cosmo self help guides. I think It'll be good to go to someone who will guide me into introspection. I feel like I'm skirting something lodged pretty deep and I'm scared to find it, but whatever it is it's paralyzing me and I need help. This is good. someone to say something to that isn't a google search engine. I can't really talk to my friends about it. When I try they just get uncomfortable and I end up making jokes to difuse it.
I am so sorry. There is no quick fix for this, but I am positive that the therapist will help you on this journey and will help figure out the root cause and help you stop this behavior for a sustained period of time, so that you feel like yourself again. A therapist will provide a safe environment, so that you can talk about anything and your therapist will be an ally and supporter of yours too
I'm just really unhappy and I can see the fork down the road where I'm either going to get help or do something really gruesome and when I come to the fork I want to choose help.
this is a good time I think
Good for you!! Choosing help is a big step and one that will yield you positive results.
Also those books will provide techniques that can help manage your behavior too, so you can use those and the link until you see your therapist that you choose.
K, I'm not ready to talk about anything else right now, I don't think. Thanks for the links.
I understand, well I wish you all the best and I hope your treatment works swiftly for you. My goal is to provide you with excellent service, so if you ever have any further questions or concerns please do not hesitate to contact me at anytime.
You are most welcome :)


text:
I bought a chromecast and sent it back. Streaming didn't work reliably from my MotoX and I honestly HATED not having a remote. I can't stand having to look at my device to navigate and then up to...
SuperSite for Windows
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Safety Enhancements at Belt Parkway's 4th Avenue Entrance
Brooklyn- State Senator Marty Golden (R-C, Brooklyn) is announcing that the Department of Transportation has responded to his request to study the safety of the entrance to the Belt Parkway at 4th Avenue, and has already installed "quik curbs" and additional signage is set to be installed next week.
Senator Golden received a concern from a local resident after the recent news of the accident on the Taconic State Parkway. Senator Golden immediately contacted the Department of Transportation to bring to their attention the concerns related to the signage, which at times, can cause confusion for motorists getting onto the Belt Parkway.
Senator Golden stated, "I thank the Department of Transportation for their speedy response to installing better and more reassuring signage and markings for all motorists who utilize the 4th Avenue entrance/exit of the Belt Parkway. We need to maintain a safe driving environment for all to the best of our ability, and if these additional "quik curbs" and signs can save lives and prevent accidents, it was well worth the effort."
Golden continued, "I can completely understand the concern in the way this was marked and I do hope now, with the new indicators, motorists will be directed properly and there will no longer be any sense of concern or potential for accidents where cars are mistakenly going in the wrong direction."
Photo #1- The Department of Transportation has installed "quik curbs" at the entrance of the Belt Parkway at 4th Avenue at the request of Senator Golden to review the safety of the entrance/exit ramp (photo courtesy of DOT).


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Mad Men recap: Shame and scandal lead Lane Pryce to a final solution
In a season filled with shocking scenes, Sunday's Mad Men offered perhaps the most stunning, capping the run of Jared Harris's Lane Pryce with a suicide in the office.
Pryce had run out of options, embezzling $8,000 from Sterling Cooper to cover his taxes back in England, then twisting slowly over several episodes as his effort to disguise the chunk of change as a Christmas bonus was undone by circumstance.
Once Don Draper discovered his dishonesty, giving him a weekend to devise a graceful exit, Pryce instead chose a different path -- leaving his partners and family in the lurch with a suicide that allowed him, finally, to duck the consequences of his actions and the inevitable shame resulting from such a startling fall.
Producers did a better job of laying the groundwork for Lane's move than some other shocking scenes this season, exposing the character as a man chafing at the rigid role laid out for him as an Englishman in New York, yet desperate at times to live up to that same image.
One moment, he's showing off his black girlfriend to snark off his veddy British father, the next he's laughing with fellow expatriates at a bar while cheering his favorite soccer team and struggling to keep his son in a very expensive school.
It was a toxic mix of pride, insecurity and longing; at times, Lane didn't even know what he wanted, beyond transcending the life he felt stuck in. Remaining in America to fund the upstart Sterling Cooper agency was the one great rebellious move of his life, and as we learned over the last few weeks, it came at a high price -- dinging him financially to the point that he was constantly on the edge of disaster.
We experienced TV watchers knew the moment he forged Don's signature on a bogus bonus check, that it would only be the start of a spectacular unraveling for Lane. But, true to Mad Men's ways, the end came with a simple discovery -- Bert Cooper looking through bank statements and alerting Don, who tried to give Lane a quiet way out. (can't forget the humorous turn at the end; Lane's first suicide attempt, gassing himself inside the Jaguar his wife bought for him, foiled by the notoriously temperamental auto's inability to start.)
And Lane's final attempt to explain himself, vaulting between obsequious pleas to Don ("I supposed I picked you [for the forgery] because you've been the most decent to me.") and bursts of anger over his view of the embezzlement as a 13-day loan, was a fitting, final showcase for Harris. Keeping us guessing about what Lane actually did until his co-workers arrived in the office Monday morning was the last, compelling touch.
More than many episodes, "Commissions and Fees" felt like an array of smaller storylines gathered around one powerful moment, though one of them included Don's daughter Sally having her first -- gulp -- period.
The payoff of the storyline -- which saw a dismissive Sally run back to her mother for comfort after rejecting her earlier in the episode -- was understandable and telling.
But the road which led there, including Sally calling creepy ex-neighbor boy Glen to Don's apartment in Manhattan, where they both went to a museum and she ditched him once her period started, felt convoluted and a bit unnecessary (perhaps an excuse to give Glen, played by creator Matt Weiner's son, a few more decent scenes this season?)
It was also great to see Roger and Don team up to try convincing Dow Corning that Sterling Cooper deserved their business. Besides giving a little screen time to the most excellent Ray Wise (as Dow's head), I had forgotten what a great team Don and Roger made in the series early days.
More than that, the writers hinted that perhaps the characters had forgotten too -- with Don irritated enough by comments from other on the success of his "little firm," that he wanted to end such talk by landing an even bigger fish.
As the big moments pile up -- Joan's sleeping with a client to get business, Peggy leaving the firm, Lane killing himself -- it makes you wonder: How exactly can Weiner end this season, short of setting off an atomic bomb?


text:
FURIOUS: Cam Preston tells Southern Response's Peter Rose what he thinks.
TRAFFIC JAM: When broken is the new normal.
LISTENING: Protest organiser Steve Gurney talks to Southern Response's Peter Rose
UNHAPPY: Hugo and Emma Kristinsson were told their original engineer was working illegally.
PLACARD PROTEST: High emotions spelt out.
IMPASSIONED: Steve Gurney addresses the protesters otuside Southern Response offices.
CAMPING OUT: Earthquake claimants have set up several protest caravans in the Southern Response carpark.


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never give up, you never know what the future has in store for you....
Sat, Jul 14, 2012 at 2:58 AM
The Music....
WITHOUT MUSIC I think the world would be boring. I think the music moves people and gets them in a happy mood to were no one else can. Music can express how people feel and help others who have a hard time showing their emotions (: Music is the only thing I have in this world that won't bring me down. With music I feel like I can express myself .... music makes me want to dance and...
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The world found out that Amy Winehouse passed away today at age 27, after being found in her London home. Sources are allegedly reporting that her death was an overdose. Further information is to be released in time.
Our thoughts and condolences are with Winehouse's friends and family. Musicians quickly took to their twitter, just like most anyone else, to share their thoughts on the tragic story. Here are a select few:
Stephen Gomez (@Stephen_James) of the Summer Set: Kurt Cobain, Jimi Hendrix, Janis Joplin, and Jim Morrison changed music, Amy Winehouse did not. Her death is nonetheless very sad, but.. I don't think her contributions to music by any means make her part of the #27club. Call me an asshole, whatever. She did have a pretty killer voice though. I never said her death wasn't sad, I never said she wasn't a great artist. Chill out.
Josh Withenshaw (@EAJosh) of Every Avenue: People should stop dying.
Alex Gaskarth (@AlexAllTimeLow) of All Time Low: Really sad to hear about Amy Winehouse. Such a massive talent. Albums on repeat, volume up to 11. Sing on, lady, sing on. RIP
Hayley Williams (@yelyahwilliams) of Paramore: Just read about Amy Winehouse. Can't believe it. She'll never truly be gone cause have you heard that voice? Rest In Peace Amy.
Pete Wentz (@PeteWentz) of Fall Out Boy / Black Cards: super sad to hear about the news. RIP. never take life for granted.
James Euringer (@JimmyUrine) of Mindless Self Indulgence: YOU DIDNT GIVE A SHIT BOUT HER WHEN SHE WAZ A LIVING DRUG ADDICT NOW U MISS HER CUZ SHEz A DEAD DRUG ADDICT FUCK U FUCK HER MOURN DA RECORD
Alex Deleon (@AlexanderDeleon) of the Cab: hate that so many people, especially talented ones, surrender their life to addiction. the only addiction you should have is to life itself.
Ronnie Radke (@RedRumRonnie) of Falling In Reverse: RT @AudreyKitching: if you're struggling with an addiction please get help! It's very serious and should be addressed ... RIP #amywhinehouse :(
Jess Bowen (@theJessSet) of the Summer Set: Making someone's death into a joke isn't going to get you a top tweet.. stop being disrespectful. RIP Amy Winehouse.
Jonathan Olivares (@ShutUpJnthn) of Shut Up And Deal: Terrible about Miss Winehouse. May her soul RIP
Jono Diener (@JonoDiener) of the Swellers: To all the passive aggressive tweets from my friends: it's upsetting Amy Winehouse passed. Don't care she had a drug problem. Just think... People should at least hear what happened in Norway because it seems 2 tragedies at once overshadow each other.
Anthony Raneri (@AnthonyRaneri) of Bayside: I guess I'll never get that Back to Black follow up I've been waiting for. Very bummed about that. RIP
Teddy Roberts (@ThisisHampshire) of Hampshire: Is Amy Whinehouse dead?
Jonathan Weber (@Jwebmusic) of Yours Truly: People ripping on Amy Whinehouse: calm down, she had a problem that took over her life, and I'm pretty sure we all have our problems
Sierra Kusterbeck (@SierraVE) of VersaEmerge: RIP Amy Winehouse. You were a huge inspiration to me.
Not in the smoking crack kind of way. Welcome to the 27 club.
Jerry Roush (@JerryRoush) ex-Sky Eats Airplane, Of Mice & Men: amy winehouse isnt dead... she's just invented "permanent planking". i mean they did try and make her go to rehab...she said no no no. they fucking tried. you said no.
Justin Siegel (@JustinSiegel) of Stars In Stereo: So insanely tragic. I really hope her label can exhibit some self control before exploiting this. RIP.
Mark Hoppus (@MarkHoppus) of blink-182: Too much death and tragedy in the past two days. Love to Norway. RIP Amy Winehouse.
Slade Echeverria (@AnarborSlade) of Anarbor: Wow RIP Amy WInehouse, such an great singer. part of the 27 club
Josh Franceschi (@JoshMeAtSix) of You Me At Six: Amy Winehouse R.I.P What a voice, what a shame. Feel terrible for anyone close to her


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Lino Diaz
Carrollton &
Farmers Branch
Lino Diaz passed away on October 7, 2012 at the age of 63 surrounded
by his loved ones. Lino was born in the Philippines on September 24,
1949 to Lorenzo and Carmen Diaz. On December 20, 1975, he married
Delza Montalbo, and they moved to the US to begin their lives
together. Lino was a devoted husband and beloved father to his three
children, Liezl, Lilian, and Lara. He cherished working for Hunt Oil
Company for over 30 years with colleagues he admired. He also
enjoyed celebrating his strikes and spares with his signature kick
and traveling the globe with his family. Friends and family are
invited to a viewing on Thursday, October 11 from 5 - 9PM with a
Rosary to begin at 8PM at Restland Coppell Chapel. Memorial Mass
will be held Friday, October 12 at 11AM at St. Catherine of Siena in
Carrollton. Interment to follow at
Furneaux Cemetery
in Carrollton. For those who prefer, in lieu of flowers, the family
requests donations to The Alzheimer's Disease Fund or the
Achievement Center of Texas.
Submitted by Edward Lynn
Branch TXGenWebSupported by
Edward Lynn Williams© Copyright
January, 2012


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- Most Recent
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Get Writing!
Share your stories with other KW readers. It's easy - just create your own:
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Go for it and write something and we might use it on Kidzworld! Then you can add it to your Kidzworld profile for everyone to see.
a poem for a child
I only can hope
a reality
It may happen
or, it may not happen
He was only able to smile, laugh, cry, and said "wa, pa, ma"
Indeed, I am concerned
however, this is destiny
that must be followed
life is only temporary
he may realize ..
Funny ... to utter a single word over mine
when I saw him .. I love him
I can only hope .. I hope he's strong with the circumstances that he experienced ...
and ... until he grows up .. I want him to be a bright child
running a straight view of life .................


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Permits for short-term events such as parades, rodeos and parking lot sales would be easier to get under zoning ordinance changes in the works at City Hall.
The proposed amendments are on a list the City Council asked its staff to prepare Tuesday and bring back to the council for approval. No timeline was set.
Part of a push to streamline city processes, the proposed changes also include:
-- Letting city staff members sign off on temporary use permits for carnivals and other short-term outdoor entertainment or enterprises; parking lot sales; and mobile trailers used as temporary classrooms or offices. The council approves those permits now.
-- Allowing individuals, instead of just the council, to initiate changes to a general development plan for the city
-- Allowing staff to approve changes to permits for local shopping centers' signs
-- Permitting individuals to start the process for a new specific plan ---- which is a blueprint for development in a certain area ---- for an amendment to an existing specific plan, or for an amendment to the general plan.
On Thursday, City Councilman John Mullin described the proposed amendments as a good step toward simplifying the city's zoning ordinance in a way that would "speed to market" projects likely to be beneficial to Poway.
"I'm pleased that there's what appears to be such a universal will to do what we can do to make it easier for the businesses to do what they do," he said.
Mullin kicked off the streamlining push last year, when he said he had heard numerous businesses and developers who wanted to invest in Poway complain that the city made doing so difficult. At the time, he was one of eight candidates vying for former Councilwoman Betty Rexford's seat, which she lost in a recall election in June.
Mullin won the election and was sworn in to the council in July. In October, he officially asked the council to consider easing its rules for temporary use and sign permits, the initiation of new specific plan and amendments to the general plan or existing specific plans, and permits for construction projects taking place on hillsides or ridgelines within the city.
The council decided at an initial workshop in February to retain approval authority for hillside and ridgeline development permits.
However, the council agreed during that session that the other proposed changes might be warranted.
Thursday's workshop saw the council focusing on concerns about neighbors' right to be notified about permit and plan amendments before they get approved and the right to appeal staff decisions.
As it stands now, the city notifies all neighbors within 500 feet of the property involved in a permit or plan amendment request. The same neighbors also can appeal decisions to the council.
The council concluded that adjacent property owners ---- rather than everyone within 500 feet ---- should continue to be told about such requests and asked the staff to include that requirement in the proposed ordinance changes.
The council also agreed that adjacent property owners should still be allowed to make appeals to the council. The fee for doing so was lowered from $765 to $100, after the council decided the existing fee was cost-prohibitive.
Mayor Don Higginson characterized Thursday's discussion as a good one. The city will continue to hold public hearings for proposed general or specific plan amendments as well as new specific plans and that any such plans must be approved by the council, he said.
Call staff writer Andrea Moss at 760-739-6654.


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Java Draw Created Jun 16, 2010 470 x 338px Unless noted Copyright 2010 alysha101.
We encourage you to submit a comment and let the artist know what you think of this drawing. Please log in or join to post a comment.
Post a comment
look so delicious, fav & 5♥
all fruits look fantastic and so beautifully drawn! 5/5
excellent draw, so detailed , keep it up 5/5
Looks like real!! 5/5
very well drawn!!
They look fresh, delicious, almost real! 5♥s
This is Almost realistic .. specially the apple and the grape ...a very neat work. Alll the Best for comp...5/5+favs
Looks very realistic and tasty :) I like the perspective from above .. 5 ♥s
wow! wonderful drawing! it looks fresh and tasty! great work alysha! 5♥s


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Open grant, contract, and cooperative agreement listings with closing dates and contacts
Research program and staff contacts for researchers seeking funding
How NIDDK funds clinical research, from preliminary clinical feasibility to large multi-center studies
Tips for applicants; grant review and management resources; and commonly used funding mechanisms, including diversity and small business programs
Grant programs for students, postdocs, and faculty
Application success rates, funding priorities, and trends
Protocols, repositories, mouse models, plasmids, and more
Labs, faculty, and research opportunities located on NIDDK campuses in Maryland and Arizona
Past and upcoming scientific meetings sponsored or hosted by NIDDK
Material transfer agreements, technology licensing, and public/private collaborations
Enlaces a nuestra información en español
Diabetes, digestive, kidney diseases, obesity, weight and more
Health tips from Dr. Griffin Rodgers, Director of the NIDDK
Current research studies and how you can volunteer
Science-based information and tips for planning an outreach effort or community event
Patient and provider resources including select CEUs
Information, tools, and partnership opportunities to improve awareness, prevention, and management of NIDDK-related diseases and conditions
General information about what NIDDK offers and other frequently asked questions
Director and deputy director biographies, Dr. Rodgers' vision statement, and the Director's Update newsletter
Organizational structure and descriptions of offices and divisions
Staff search and staff listed by offices and divisions
President's budget request, congressional testimony, and other legislative information
Strategic plans, research progress reports, and statistical reports
NIDDK Advisory Council, Board of Scientific Advisors, and committees that coordinate research activities
Overview of NIDDK activities in each major research area, including research advances, research coordination, and health information
How to find current openings and related resources
Frequently asked questions about the Institute
Locations in Bethesda, Maryland and Phoenix, Arizona
News releases, research updates, grantee news, and newsletters
Media contacts, statistics, multimedia gallery, and more resources
Upcoming and past meetings
Social media, RSS feeds, and more
Health Information Center
You can also order print materials from our online catalog.
The steps you take to keep your kidneys healthy help the rest of your body too. Talk to your health care provider to find out the steps that are right for you.
If you are at risk for kidney disease, the most important steps you can take to keep your kidneys healthy are:
Find more questions to bring to your next medical visit.
Read about what to do if you have kidney disease.
A doctor explains the two tests for chronic kidney disease (CKD): blood test, which checks your Glomerular Filtration Rate (GFR), and a urine test.
PDF files require Adobe Acrobat
This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The NIDDK translates and disseminates research findings through its clearinghouses and education programs to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts.
This information is not copyrighted. The NIDDK encourages people to share this content freely.
September 17, 2014
Phone: 1-800-860-8747 | TTY: 1-866-569-1162 | Email: email@example.com | Hours: 8:30 a.m. to 5 p.m. Eastern time, M-F


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Raise a glass to your colleagues and customers with a selection from ePromos' assortment of custom drinkware. For a truly generous company gift, choose from our great range of beverage gifts, which includes everything from logo coasters and tumblers to extravagant barware sets! Our Promo-Know-How Specialists will help to refresh your internal marketing strategy with custom drinkware items sure to agree with your budget. Let ePromos top off your plans for customer acquisition and retention with our esteemed promotional products!
This Perfect 8 Essentials Promotional Gift Sets makes the perfect orientation or back-to-college gift! All imprinted with your branding, which is sure to leave a lasting impression on the recipient!
This hot & cold custom tumbler gift set the perfect gift set for any occassion.
The 16 oz. Solo Cup style custom tumblers w/ snacks gift set is a great giveaway to give your brand immediate exposure for any event.
Give these favorite 5 essential items that everyone packaged as one gift with these Perfect 5 promotional gift sets all imprinted with your logo for the ultimate brand exposure.
Give all the essential promotional items packaged in one gift with these Perfect 10 promotional gift sets all imprinted with your logo for the ultimate brand exposure.
This promotional sports bottle also comes with outdoor necessities like sting relief gel and sunblock.


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Iron Studies (Fe) are a set of blood tests to measure and estimate the amount of elemental iron carried in the blood and stored in the body tissues. Iron is an essential component of Haemoglobin, and Iron deficiency is a common cause of anaemia (low blood count).
How the Test is Performed
Iron Studies (Fe) is a blood test. A few millilitres of blood from a vein are required.
Medical Conditions and Symptoms
Iron Studies (Fe) are commonly performed in the setting of anaemia (low Haemoglobin or low blood count), especially a so-called microcytic anaemia, where the red blood cells are decreased in size (measured on the Full Blood Count – FBC – as the Mean Cell Volume – MCV). Iron-deficiency anaemia will often show suggestive clues on the peripheral blood film – a test where the blood cells are looked at under a microscope, and specific abnormalities of cell shape and size are described.
Iron stores, most accurately reflected by the ferritin level, may be decreased long before red blood cell production is affected, and before actual anaemia develops.
Symptoms of anaemia include pale skin and mucous membranes (such as the tongue, and the conjunctiva lining the inside of the lower eyelids), tiredness, shortness of breath on exertion and sometimes postural light-headedness.
A condition called haemochromatosis occurs when the body stores too much iron. This can result in damage to organs such as the heart, pancreas, liver, and skin – so-called "bronze diabetes". A similar situation can occur in people who receive frequent blood transfusions for many years (for example, for thalassaemia), due to a build-up of iron which is carried in the transfused red blood cells.
Test Results Explained
Iron Studies (Fe) consist of a number of components; some are more useful than others. The most accurate marker of total body iron stores is Ferritin – the first component to fall in the setting of iron deficiency. Serum Iron is the next most useful component, giving an estimate of iron being carried in the blood. Transferrin is a protein which caries iron in the blood; it may be increased in the presence of inflammation or infection anywhere in the body and is therefore less useful. Interpretation of these values can be confusing, and the laboratory report usually gives some guidance.
If iron deficiency is discovered, it usually means that the cause needs to be identified and iron treatment started – in the form of iron tablets or liquid. Small amounts of blood loss over a long period of time is a common cause of iron deficiency, and many patients undergo tests such as Upper GI Endoscopy and Colonoscopy – "Tops and Tails" – to search for a bleeding source in the stomach or bowel. Ocassionally, iron deficiency is due to an inadequate diet.
Related Specialists
- General Practitioner (GP)
- General Physician
- General Surgeon
- Haematologist
- Gastroenterologist
- Gynaecologist
- Paediatrician
Related Procedures
- Blood Test (venesection)
- Intravenous Cannulation
- Endoscopy of the Upper Gastrointestinal Tract
- Colonoscopy
Related Tests
- serum Iron
- Transferrin
- Transferrin Saturation
- Ferritin
- Total Iron Binding Capacity (TIBC)
- Haemoglobin
- Full Blood Count
- Urea & Electrolytes
- Blood Group or Crossmatch
- Coagulation Profile
- Endoscopy of the Upper Gastrointestinal Tract (Upper GI Endoscopy)
- Colonoscopy
- Sigmoidoscopy
- Abdominal CT
- Barium Swallow
- Barium Enema
- Faecal Occult Blood (FOB)
Also Known As
- Haematinics
- Wikipedia – Iron deficiency anemia*
- Australian Iron Studies Advisory Panel – for doctors
- haemochromatosis.org.au
* Anemia – American spelling for Anaemia


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7400 East Roosevelt Boulevard
Rhawnhurst, Philadelphia, 19152
Commute to Downtown Philadelphia
Most errands can be accomplished on foot.
Many nearby public transportation options.
Flat as a pancake, good bike lanes.
About your score
7400 East Roosevelt Boulevard has a Walk Score of 80 out of 100. This location is Very Walkable so most errands can be accomplished on foot.
This location is in the Rhawnhurst neighborhood in Philadelphia. Nearby parks include Holy Terrors Youth Org Inc, Mayfair Playground and Pelbano Playground.
Explore how far you can travel by car, bus, bike and foot from 7400 East Roosevelt Boulevard.
7400 East Roosevelt Boulevard has good transit which means many nearby public transportation options. Car sharing is available from Zipcar and RelayRides.
Bus lines:
20 Franklin Mills Mall to FTC
0.0 mi
14 Oxford Vally/Neshaminy Malls to FTC
0.0 mi
1 Parx Casino to 54th-City
0.0 mi
50 Parx/FrankMillMall to Frankford TC
0.2 mi
77 Roosevelt-St Vincent to ChestntHill
0.2 mi
70 Fkd-Gregg/Torr-Cottmn to FRTC
0.2 mi
Car shares:
7400 East Roosevelt Boulevard compared to all of Philadelphia.
Lower crime area.
Higher crime area.
How do you feel walking near 7400 East Roosevelt Boulevard?
Thanks for your feedback!
View all Rhawnhurst apartments on a map.
Search for homes in Philadelphia or find a Philadelphia real estate agent who knows walkable neighborhoods. Links will open on our partner site Redfin.com.
7400 East Roosevelt Boulevard is in the Rhawnhurst neighborhood. Rhawnhurst is the 64th most walkable neighborhood in Philadelphia with a neighborhood Walk Score of 69.
Moving to Philadelphia from another city? View our moving to Philadelphia guide.


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grain: 1/6 of 6
Behind the Label: read and download the best articlesThe Ecologist has produced a printable PDF magazine of the best articles from our popular Behind the Label series more...
US used quarter of 2008 grain crop to make biofuel
25th January, 2010More than a quarter of the total US grain crop was turned into ethanol to fuel cars last year, according to a new analysis more...
Know your oats: grow your own grains
Clarissa Dickson Wright and Johnny Scott
25th August, 2009Growing your own food can go beyond fruit and veg if you have space and the right soil. Read on for Clarissa Dickson Wright and Johnny Scott's guide to grain crops more...
Draining paddy fields could cut methane from rice production
19th June, 2009Chinese scientists have discovered that draining rice paddies just once every growing season may help reduce global methane emissions from the industry by almost a third more...
Factories Around the World Consider Halting Production of Biofuels as Price Soars
26th February, 2007Less than a month after George Bush used his State of the Union address to announce that the US would use biofuels to achieve energy independence, companies across the globe are threatening to stop production because of rising prices. more...
Behind the label: Kellogg's Nutri-Grain Soft Bake Bars
Pat Thomas
1st March, 2006If you 'deskfast' with sugary, fat-filled cereal bars instead of eating a good breakfast you could be doing untold damage to your body and mind. By Pat Thomas more...
grain: 1/6 of 6
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Cold Title New Album
This is one of my favorite bands, so I was very excited to see a new album on the way. 'Superfiction' is the title of the new Cold release, which is scheduled to come on June 28th.
I was lucky enough to hear about 1 minute of the new single, "American Dream". You'll have the chance to hear the whole song on the Banana in March.


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The Pope's Red Stefanelli's
The following is from the News Democrat (IL) via McClatchy-Tribune Information Services, dateline March 5, 2013; byline Roger Schlueter, headline "The devil wears Prada … but what about the pope's red loafers?"
In 2006, Hollywood showed us that "The Devil Wears Prada." Could it be that Pope Benedict XVI made questionable fashion choices concerning his very sole? This was the rumor that began swirling after Cardinal Joseph Ratzinger became Pope Benedict XVI in April 2005. Retiring the brown shoes worn by his predecessor, John Paul II , Benedict brought back the red loafers favored by many previous popes.
His fashion sense, which, included Serengeti sunglasses and Geox-donated walking shoes, quickly gained the notice of designers. In its 2007 list of the best-dressed men in the world, Esquire magazine named Benedict "accessorizer of the year" for his ornate papal habits paired with those red shoes. Perhaps because of that, you'll still find stories that claim Benedict's red footwear are none other than that chi-chi Italian brand Prada costing who knows how much.
Well, those shoes are worth hundreds of dollars a pair, but they aren't Prada — and they didn't cost Catholics a penny. They're the work of Adriano Stefanelli , an Italian shoemaker who, out of love for his church, reportedly began making shoes as a gift for the pope a decade ago.
"When I was a child and people would ask me what I wanted to do when I grew up, I used to answer, 'I'd like to make the pope's shoes,'" Stefanelli told Catholic Online (www.catholic.org) in 2008. "Today, it seems to me, I've realized my childhood dream." . . . The shoes — which Stefanelli describes as "ruby red, almost bordeaux" — are hand-sewn and take nearly a month to make. [They cost about $550 a pair.]
The return to red served several purposes for Benedict, who loves cats and relaxed at night by practicing the piano, [said] Lawrence Cunningham , a professor of theology at the University of Notre Dame . . . . Traditionally, he said, red is worn to symbolize the blood shed by Catholic martyrs. It also signifies the burning fire of God's love. . . .


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You will learn How to get 1st Iqama for your Family- Latest procedure 2017.
Find useful info to make the most of your expat project and get in touch with expatriates
Capital of the Kingdom of Saudi Arabia, Riyadh welcomes every year a large number of high skilled expatriates, settling here to live and work.
Big global foreign companies, as well as diplomatic missions, are settled in the city, offering job opportunities to professional expats. Attractive salaries, noincome tax, skilled profiles are interesting assets to invite you to move here.
Latest articles
You will learn How to get 1st Iqama for your Family- Latest procedure 2017.
I am writing this article so that people may be aware of the procedure to acquire/get a license in Riyadh, Kingdom of Saudi Arabia.
When moving to a foreign country, having a list of useful numbers can definitely help you get around. Here are some.
Riyadh, Saudi Arabia's capital city, has a range of means of transports from which you can choose to move from one place to another.
Saudi Arabia has various means of transports from which you can choose to move from one region to another: bus, train, taxi, etc.
11 months ago
Our blog is about our life in Riyadh and our experience as expats in Saudi Arabia. We write also about our travel experience! Hope you like it!
2 years ago
Saudi Arabia from the perspective of a twenty-something healthcare worker at King Faisal Hospital in Riyadh.
2 years ago
Welcome to our blog.I am a parent volunteer in my kids school.Al Forsan international schools in Riyadh. By FIS parent to parents! NB: it's not an official blog from school, it's my personal blog
Buy, sell and find all you need: deals, furniture, cars, household appliances and many more.
Try it, recommend it! Share your opinion and get in touch with professionals and services tested and approved by expats.
|VEGA Modern Traveler Services Co. Ltd. Dove Plaza, Umm Al Hamam Street , Riyadh


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Here's a novel way to help raise funding for the national park system: Search the Internet.
Yep, thanks to the folks at Yahoo!, there's now a search engine that will generate money for non-profits.
The way it works is you make "Good Search" your search engine of choice. When you install the search engine, you're given a chance to select a charity that you'd like to raise money for. Then, every time you run a search, a portion of the advertising revenue that Yahoo! collects from the advertisers on those search pages will be directed to your charity of choice.
How much can this generate? Last year Internet advertising generated about $6 billion for search engines. With Good Search, the folks at Yahoo! estimate that each individual search will generate one-cent for your charity.
That seems like small change, but in cyberspace things build up quickly. For instance, if 10,000 national park advocates made Good Search their default search engine, Yahoo! calculates they would generate $73,000 a year for the park system simply by running two searches a day.
I did a quick survey of Good Search charities/non-profits directly related to the national parks and found two: the National Park Foundation and National Parks Conservation Association.
Seems like a simple fund-raiser, no?
'Searching' for Park Funding
Here's a novel way to help raise funding for the national park system: Search the Internet.


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I am a female, 5' 8" and I weigh 190 lbs. I have lost upwards of 80 lbs. In the last year and have been left with a still protruding stomach. Now, would liposuction or a tummy tuck be a better remedy for getting more of a flat appearance in my stomach as well as a smaller waist size?
Liposuction Vs. Tummy Tuck After Weight Loss?
Doctor Answers 16
Liposuction vs. tummy tuck
Congrats on your weight loss. Unfortunately, with that much weight loss, you most likely will need a tummy tuck. Liposuction can help taper in the hips and flanks to complement the tummy tuck. My office is only a few miles from you. I would be happy to discuss your options in person. Thank you.
Liposuction or tummy tuck after weight loss
If your abdomen is still protruding, you might have internal abdominal fat yet to lose. Check to see if your abdomen is flat when you lay on your back. If the tummy is still prominent a tummy tuck alone will not keep things in check. Liopsuction is an excellent way to improve contour, though has a very poor track record for sustained weight loss, high volume or not.
Learn more: http://www.peterejohnsonmd.com/tummy-tuck
Tummy tuck is a better option post weight loss
I would agree with the colleague that suggested combination of the liposuction and tummy tuck. You have done a great job by losing the 80 plus lbs. Liposuction will remove fat and you have done that already.
You might also like...
Which Procedure is Best?
Dear B.B. I would agree with most of what has already been said. Without seeing your photos, I would venture to say you need both liposuction and a tummy tuck. We use a laser to help soften the fat before liposuction. I would also recommend Power-Assisted Liposuction because it will remove more fat in a precise manner with a higher degree of safety.
Learn more: http://www.naturallookingresults.com
Three Elements to Abdominal Contouring: Fat, Skin, and Muscle
Choosing the best procedure for abdominal contouring requires evaluation of three elements: Is there too much fat under the skin; Is there too much (loose) skin; What is the condition of the abdominal muscles. Excess fat is best corrected with liposuction, excess skin with skin removal, and separation of the muscles (diastasis) with plication.
In most cases all three components are done at the same time with a full abdominoplasty (tummy tuck). After significant weight loss, the fat component may be less of an issue but still should be considered. Lastly, it is advisable to wait until your weight stabilizes prior to surgery to get the best, longest lasting result.
Tummy improvement after weight loss
For tummy tuck versus liposuction, it is very difficult to give meaningful information without photos.
Thank you for your question.
It is very difficult to give meaningful information without photos. A face-to-face consultation is best.
To know what some of your options are, see two or more board-certified plastic surgeons in your area for a full and complete evaluation to make sure you are a good candidate and that it is safe for you to have surgery. I hope this helps.
Tummy Tuck More Beneficial Than Lipo After Weight Loss
Without the benefit of photos or an exam, I feel that you would have a better result with a tummy tuck than liposuction after your 80 pound weight loss. Liposuction will have little, if any, effect on the excess skin. A tummy tuck will also allow your stretched out abdominal muscles to be tightened.
Tummy Tuck or Lipo After Weightloss
Liposuction helps eliminate bulges of fat from various areas of the body with minimal scarring and quick recover times, which is, in part, what makes it such a popular procedure. While the changes in body contour can be quite dramatic after lipo, liposuction alone does not affect muscle tone or skin tone.
In general, without photos or a consultation, I can say that weight loss often tends to result in sagging or loose skin. A person with hanging skin or a separated rectus abdominis muscle would achieve better results from a tummy tuck.
The rectus abdominis muscle is the vertical muscle in the middle of your abdomen. It functions much the same as how shoe laces work in a shoe. Learn more at the web resource provided.
Learn more: http://www.cosmeticsurg.net/blog/2009/07/07/flat-stomach-more-exercise-or-a-tummy-tuck/
Tummy contouring after weight loss
Congratulations on your weight loss. If you are done with losing weight and your weight loss has stablized, you may benefit from a tummy tuck +/- liposuction of your waist. Another option for weight loss patients is a procedure called a circumferential body lift. A physical exam would be needed to make any recommendations. Please visit with a board certified PS to learn more about your options.
Dr. Basu
Houston, TX
Learn more: http://www.basuplasticsurgery.com
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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ben4321 (483) Hoboken, New Jersey | October 2, 2011
I wouldn't go here seeking out beer, but the food was excellent, and if you need a beer while you are there, there are a decent number to be had. Our service was fine, but kind of slow, with long breaks between courses and lots of apologies from the waiter. The reason to go here though, is clearly the food, which again, was excellent. I'd return, but honestly, the beer would be an after thought in my reasoning.
j12601 (574) Poughkeepsie, New York | January 22, 2009
This is a restaurant that happens to have fairly decent beer. Nothing mind blowing in the beer department, but the food is solid, fresh, and seasonal. On tap tonight were Stella Artois, Dundee Festive, Goose Island Honkers, Ommegang Abbey, Leffe Brune, and a Saranac fruit beer. Bottles have a nice Belgian tint with Chimay, and Rochefort 6, with some of the more well known micros from the US as well. I'd recommend going for the food. Husband and wife owners in the kitchen, both CIA grads. They just added a fixed price menu for $30 with an appetizer, salad, entree, and dessert. Everything on the menu is fair game, with maybe 5 items requiring a small supplement.


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Workers at a carpet tile factory were left 'shocked' yesterday to learn that the plant is to close from the end of next month, with the potential loss of 115 jobs.
One employee at the InterfaceFlor factory in Shelf said the workforce had been expecting to hear about a takeover rather than closure.
The worker, who did not want to be named and has worked at the company for 20 years, said: "The union was called in about an hour before we were told. It was a shock to learn that the factory is closing. We have seen work being transferred to Holland, but were expecting an announcement about a takeover following the death of the InterfaceFlor founder last year. We're all in a state of shock and in limbo until things become clearer."
InterfaceFlor, which has owned the Shelf plant since the late 1970s, said the move was due to falling demand in the UK. It has started consultations with employees and the Unite union over plans to close the Shelf manufacturing and distribution operations in a bid to save about £4 million a year.
Up to 115 jobs, mainly in manufacturing and a few office staff, out of the 204 workforce could be affected by the cuts. The company is looking to offer voluntary redundancy and redeployment opportunities to other parts of its business.
InterfaceFlor intends to keep its UK headquarters in Shelf, along with sales and marketing, design and development and a sample making unit.
Lindsey Parnell, European president and chief executive, said: "It is with regret that I must announce that InterfaceFlor is entering into consultation over ceasing manufacturing at Shelf. The business case for the proposed closure is, however, strong."


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Have Toyota Questions? Ask a Mechanic for Answers ASAP
do you mean when you are going downhill the car picks up speed?
what has the service manager told you at the dealer?
did anyone roadtest the car with you?
ok. when you set the cruise control and are on a flat road the cruise control will maintain the set speed by opening and closing the throttle to maintain the proper speed.when you are going downhill and speed increases all the cruise control can do is close the throttle,if thehill is steep where the car picks up speed the cruise control does not have the ability to apply the cars brakes or downshift the transmission into a lower gear,at that point you would cancel the cruise by hitting the brake pedal and then if necessary down shift to a lower gear. below is copied out of the owners manual.if you have further questions on this let me know
n Situations unsuitable for cruise control
Do not use cruise control in any of the following situations.
Doing so may result in control of the vehicle being lost and could cause an
accident resulting in death or serious injury.
l In heavy traffic
l On roads with sharp bends
l On winding roads
l On slippery roads, such as those covered with rain, ice or snow
l On steep hills
our 2010 toyota camry le cruise control does not always hold the set speed when it goes down hill. What is the problem and how do we address this situation?
this is your post correct? now are you saying this happens without the crusie control on?
now are you saying this happens without the crusie control on?
do you want me to put in a refund request for you?
ok. thank you.
there will be an up coming 2 part recall on your vehicle for the gas pedal getting caught on the floor mat and also a possible brake override system being installed on the camrys as part of this recall. i havent seen any info from toyota as of yet,you can google gas pedal sticking to read info about the recall,i dont think this is what youre describing but maybe worth reading. there hasnt been any reports of the rpms rising or the engine revving caused by the electronic throttle control malfunction according to toyota.
are you driving about the same speed when this happens? if so what is the speed.
or can this occur at all speeds?


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Stone Hedge - located at Oberon
House, Oberon
Rated 5 out of 5 stars 3 reviews
Confirmation within 24hr
From $561 per night {{quote.pricing.message}} Total {{quote.pricing.price | format:'currency':'short'}} for
Min 2 - 4 nights stay
For your added security, this property is only managed in Australia and we never request payments be made to overseas bank accounts.
Well appointed self-contained country house on 140 acres at Oberon. Accommodates up to 15 people. 6 bedrooms, 4 bathrooms. Private access to 2km trout stream. Pool table, table tennis, log fires, central heating. BBQ facilities.
Stone Hedge offers accommodation for large groups of up to 15 people, ideally suited for several families. A fully equipped house, all bed linen supplied. Every thought has been given to comfort. It has six well-appointed bedrooms, two of which interconnect. There are three queen beds, one double bed and eight single beds. All bed linen, pillows, blankets and doonas are provided.
Disabled access and facilities
Two and a half hours drive from Sydney and one hour beyond Katoomba, Stone Hedge is located ten minutes from the township of Oberon.
Local Attractions
At 1100 metres above sea level, with a true mountain climate, including occasional snowfalls, Oberon features restaurants, shops, tennis courts, heated swimming pool and a challenging 18-hole golf course overlooking Lake Oberon. Nearby attractions include Jenolan Caves, Kanangra Boyd National Park, Lithgow, Bathurst and Abercrombie Caves.
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Note: Pricing is subject to change, and a minimum stay period and other conditions may apply. You should confirm pricing with the property owner. Bookings paid through the Stayz online booking system incur a 2% Service Fee.
Prices listed based on 15 adults. Property has 12 beds and can sleep a maximum 15 people.
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Fans of the Jackass collective will rejoice today with news of its fourth feature film, Jackass Presents: Bad Grandpa, due out October 25. This time around however, Johnny Knoxville has ditched the band's perverse assortment of random pranks, opting rather to reprise his role as the senile Irving Zisman in a narrative piece that follows the elderly man cross-country as he gets into his usual antics. With the young Jackson Nicholl tagging along as Irving's grandson, the rest of the film features "real people, real actions, real messed up," as the trailer describes it. Stay up-to-date on the forthcoming film here.
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text: This is a wonderful book which is a series book number 3 of the series. The book is a slow starting book with alot of different characters which you have keep straighten out so you can fiqure if there was a missing person or is the person dead. The story tells you of a friend who is getting married but when the detetective gets to the wedding he finds every one asleep et one missing groom. Two women have started a business together to hire the people in town but after one of the women meets a man and falls in love the two womens relationship becomes strain You will have to read the book to find out what happens . This is a mystery, love story and has religion thru out the book. This is a must to read


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MAC Manish Arora Color Story Information
MAC Cosmetics Manish Arora (October 9th, 2008) (Limited Launch)
(This image is not the promotional image for the launch.)
The Raj is all the rage! Modern to the max, exotic in the extreme, Indian design guru, Manish Arora, has teamed up with MAC to say "namaste" fashion world! His maximilistic vibe puts Vishnu in the vanguard, bursting with Blush-Devil and pink Swoon style and sophistication. With new lipstick, lipglass, blush and Eyes on Manish collections, expect kaleidoscope clash, shocking new combinations, colour-cult compacts! Take a trip to Manish Mania!


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AFRICA was in a celebratory mood after Barack Hussein Obama became America's first black President. The continent, like most of the world, had invested a lot of hope in the Obama presidency. But after more than seven months in office, Obama is yet to distance himself from most of the key foreign policy objectives of the discredited George W. Bush administration.
As far as Africa is concerned, one of the most controversial steps taken by the previous U.S. administration was the setting up of the U.S. Africa Command (Africom) in 2007. Bush, in a major policy speech in 2003, had said that 25 per cent of the oil that the U.S. imported should be sourced from the African continent. The White House, in a statement, spelt out the reasons for setting up Africom: "[It] will strengthen our security cooperation with Africa and set up new opportunities to bolster the capabilities of our partners in Africa." Another stated goal was to strengthen "democracy" on the continent. The most important reasons, to control the rich resources of the continent and to set up military bases there, were not mentioned.
The Obama administration, like the previous one, views Africom as an important tool in the "global war on terror". The "war on terror" is being used by Washington to strengthen its military presence on the continent. The U.S. military presence in the Horn of Africa has seriously destabilised the region. The bloodletting in Somalia is threatening to spread into neighbouring Ethiopia, Kenya and Eritrea. With U.S. backing, Ethiopia has emerged as the regional policeman.
The African Union (A.U.) and other regional groupings such as the Southern African Development Council (SADC) and the Economic Community of West African States (ECOWAS) have rejected the very rationale behind the creation of Africom. The fact that no African country has offered basing facilities for Africom despite the best efforts of the Bush administration illustrates the deep suspicion that the continent has towards Africom.
Most African leaders see Africom as an effort at military intrusion into the continent and a crude attempt to counter Chinese influence. China has funnelled massive development aid into the continent and is the biggest market for the continent's bountiful mineral riches.
It is no surprise that Obama has taken on the Africom agenda from his predecessor, albeit without much fanfare. While candidate Obama was critical of many aspects of the Bush administration's foreign policy, he was supportive of Africom. Obama had said: "There will be situations that require the U.S. to work with its partners in Africa to fight terrorism with lethal force. Having a unified command fighting in Africa will facilitate this action."
Africom is a unified command that brings all U.S. Defence Department programmes in Africa under one umbrella. Missions range from anti-terrorism programmes to maritime security initiatives and military-to-military training exercises with many countries. Throughout the Cold War and more than a decade after that, the U.S. did not have a military command for Africa. U.S. military activity in Africa was conducted by three military commands: the Central Command, which was responsible for Egypt and the Horn of Africa along with West and Central Asia; the Pacific Command, which had strong links with Madagascar and other small islands in the Indian Ocean; and the European Command, which was responsible for most of the continent.
Obama, during his recent visit to Ghana, his first official tour of an African country, did not mention Africom. The Obama administration prefers to pursue its military and strategic objectives in the continent in a low-profile manner – it has doubled Africom's budget and increased funding for counter-terrorism projects in the continent. This includes funding for weapons and military training at a time when American military aid to other parts of the world is drying up.
Most of the funding is going to pro-American authoritarian regimes such as the ones in Ethiopia, Equatorial Guinea and Chad. Impoverished Equatorial Guinea and Chad are big oil producers. Ethiopia has been used by the U.S. to prop up the tottering Transitional Federal Government of Somalia. The Obama administration is paying special attention to the Counter-terrorism Engagement Programme, the official goal of which is to "build political will at senior levels in partner nations for shared counterterrorism challenges".
The 2010 U.S. Federal Budget includes $42 million for the Trans-Sahara Counter Terrorism Partnership (TSCTP) and the East African Strategic Initiative. The TSCTP links the U.S. with Mali, Chad, Niger, Mauritania, Nigeria, Senegal, Tunisia, Morocco and Algeria. The Eritrean government, which once was the favoured recipient of U.S. largesse on the continent, stated that "the misguided acts of intervention and supply of weapons by the U.S. have not advanced the cause of stability in Somalia".
Much of the U.S. military activity in the Horn is conducted from the Camp Lemonier Base in Djibouti. Observers say that the fact that Obama chose Ghana as his first port of call is indicative of the American agenda. The West African state has started producing oil in commercial quantities and is soon going to be an oil exporter. Other West African states are already big oil exporters. Oil and gas deposits are being discovered in the Gulf of Guinea.
Washington has been trying to convince key West African states to host Africom. Liberia at one time was said to be predisposed to hosting Africom. The Bush administration tried to convince Nigeria to engage with Africom. Obama's charm offensive in Ghana, African commentators feel, could be a bid to convince the new government there to be more accommodative towards Africom. Ghana, like Nigeria, is a member of the Non-Aligned Movement (NAM), which remains steadfastly opposed to militarisation.
The stated purpose of Obama's visit was "to strengthen the U.S�relationship with one of our most trusted partners in sub-Saharan Africa, and to highlight the goal sound governance and civil society plays in promoting lasting development". But many Ghanaians are wary of the hidden agenda. Ghana is ideally located to serve as Africom's base as it straddles the vast oil reserves in the Gulf of Guinea.
Base Access Agreement
Ghana already has a base access agreement with the U.S., signed during the Bush presidency. Under this, the U.S. has access to local military bases for combat, surveillance and other military activity. Legally, the bases belong to Ghana, but for all practical purposes the U.S. has a free run. Similar agreements have been signed between the U.S. and the governments of Gabon, Botswana, Kenya, Mali, Morocco, Namibia, Sao Tome and Principe, Senegal, Sierra Leone, Tunisia, Uganda and Zambia. Algeria has allowed the U.S. to fly P-3 "Orion" aerial surveillance aircraft from the Tamanrasset airfield in the south of the country.
This is incontrovertible evidence that though almost all the governments in Africa are ostensibly against Africom, many of them are not averse to lending a helping hand to the U.S. in less visible ways.
The West has a long history of intervening in the region. The proceedings against Charles Taylor, the former President of Liberia in the War Crimes Tribunal, have revealed that the U.S. Central Intelligence Agency (CIA) played a role in his ascent to power. According to Taylor, he was allowed to "escape" from a high-security American prison. Taylor was serving a prison sentence in the U.S. in the late 1980s. Khwame Nkrumah, the first President of Ghana and a pan-African visionary, was overthrown in a CIA-backed coup in 1966.
France, a former colonial power, has 10,000 troops stationed on the African continent. Between 1997 and 2002, France intervened militarily 34 times in the continent. France has drawn up secret defence agreements with many of its former colonies and these give it access on a priority basis to natural resources such as oil, gas and uranium.
During a speech to the Ghanaian parliament, Obama spelt out the American policy for the region: "We have a responsibility to support those who act responsibly in the region and to isolate those who don't, and that is exactly what America will do." The Obama administration has not relaxed the draconian sanctions against Zimbabwe despite a unity government being in place there. Ordinary Zimbabweans are in desperate need of essentials such as food and medicine, but the U.S. administration's priority continues to be to isolate the Zimbabwean President, Robert Mugabe.
Washington has been piling pressure on Sudan by raising the bogey of humanitarian intervention. Among the stated goals of the Obama administration is "ending autocracy in Zimbabwe and human devastation in Darfur". Obama, during one of the debates in the run-up to the presidential election, said that it was in America's "national interests" to intervene in places where ethnic cleansing and humanitarian disasters took place. He mentioned Darfur as a region where the U.S. could provide logistical support.
It is, therefore, not surprising that Africans in general view Africom as a distinct threat to their sovereignty and associate it with neocolonialism.
Islamist insurgents patrol a street in Mogadishu, Somalia, on July 13. "Intervention and supply of weapons by the U.S. have not advanced the cause of stability in Somalia," states the Eritrean government.


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Joe Cole off to a losing start with Liverpool
Joe Cole made his debut for Liverpool yesterday but could not prevent
Roy Hodgson's side losing 1-0 in Germany to Borussia Monchengladbach.
The midfielder started in a strong Liverpool line-up as boss Hodgson included his England World Cup contingent for the first time, including Steven Gerrard , Jamie Carragher and Glen Johnson .
However, Hodgson admitted their extended break has hampered preparations.
'I don't even think we're going to be together as a team as I would like us to be on August 15 as we are still reintegrating players,' he said.


text:
Safety and Effectiveness of Combining Hydroxyurea (HU) With Didanosine (ddI) and Stavudine (d4T) for Treatment of HIV-Infected Adults
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to compare the safety and effectiveness of 9 doses of HU in order to find the best dose of HU to use with ddI and d4T in fighting HIV infection.
HU plus ddI plus d4T appears to be a suitable anti-HIV drug combination for long-term control of HIV. This combination can sharply decrease viral load (level of HIV in the body) with few side effects, making it easy to take.
|HIV Infections
|Drug: Hydroxyurea Drug: Stavudine Drug: Didanosine
|Phase 1
|Study Type:
|Study Design:
|Intervention Model: Factorial Assignment
Primary Purpose: Treatment
|Official Title:
|A Phase I/II Study of the Safety and Antiretroviral Activity of Nine Hydroxyurea Regimens in Combination With ddI and d4T in Subjects With HIV Infection
|Estimated Enrollment:
|Study Start Date:
|May 1999
The combination of HU plus ddI plus d4T appears to be suitable for long-term control of HIV in that it: (1) has a novel resistance/rebound profile demonstrating virus suppression even in the presence of ddI-resistant mutants; (2) can produce a pronounced fall in viral load; and (3) is well tolerated (over 200 patients have been treated for up to 3 years with minimal side effects).
Patients are stratified by antiretroviral experience: naive (no more than 2 weeks of therapy) versus experienced (more than 2 weeks). Patients must discontinue all antiretroviral therapy for at least 28 days prior to randomization to 1 of 9 HU treatment arms. Treatment arms are divided into 3 HU dose categories: very low, low, and medium. Within each category HU is administered daily on 3 different dosing schedules. Depending on viral load, patients on the very low and low dose arms may have the opportunity to intensify their HU dose at any time beyond Week 12, provided no Grade 3 or 4 HU-related toxicity is present (these patients are monitored for an additional 8 weeks following intensification). All patients receive ddI and d4T at the same doses every day. When 50% of patients have completed 24 weeks of treatment, an analysis is made to determine whether or not to continue the 52-week study without modifications. Patients are monitored periodically for changes in plasma HIV RNA, CD4 cell counts, weight, and symptoms.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
Patients may be eligible for this study if they:
- Are HIV-positive.
- Have a viral load of 5,000 to 100,000 copies/ml.
- Are willing to stop all anti-HIV medications for at least 28 days before receiving study drugs.
- Are at least 18 years old.
Exclusion Criteria
Patients will not be eligible for this study if they:
- Have a history of opportunistic (AIDS-related) infection.
- Have a history of pancreatitis or other serious condition.
- Have any cancer that will require chemotherapy within the next 24 weeks.
- Are allergic to ddI or d4T.
- Have received an HIV vaccine within 28 days of study entry.
- Have received a red blood cell transfusion within the past 60 days, or have had repeated transfusions at any time in the past.
- Abuse alcohol or drugs.
- Have received certain medications.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00002427
|United States, California
|AIDS Healthcare Foundation
|Los Angeles, California, United States, 90027
|San Francisco VA Med Ctr
|San Francisco, California, United States, 94121
|United States, Connecticut
|Gary Blick MD
|Stamford, Connecticut, United States, 06901
|United States, District of Columbia
|Dr Bruce Rashbaum
|Washington, District of Columbia, United States, 20037
|United States, Florida
|IDC Research Initiative
|Altamonte Springs, Florida, United States, 32701
|Boulevard Comprehensive Care Ctr
|Jacksonville, Florida, United States, 32209
|Center for Quality Care
|Tampa, Florida, United States, 33609
|United States, Georgia
|AIDS Research Consortium of Atlanta Inc
|Atlanta, Georgia, United States, 30308
|United States, Massachusetts
|New England Med Ctr
|Boston, Massachusetts, United States, 02111
|United States, New York
|Albany Med College
|Albany, New York, United States, 122083479
|Mt Vernon Hosp
|Mt. Vernon, New York, United States, 10550
|United States, Pennsylvania
|Univ of Pennsylvania Med Ctr
|Philadelphia, Pennsylvania, United States, 19104
|Thomas Jefferson Univ
|Philadelphia, Pennsylvania, United States, 19107
|United States, South Carolina
|Coastal Carolina Research Ctr
|Mount Pleasant, South Carolina, United States, 29464
|United States, Texas
|Univ of Texas Southwestern Med Ctr of Dallas
|Dallas, Texas, United States, 75235
|Univ of Texas Med Branch
|Galveston, Texas, United States, 775550835
|Montrose Clinic
|Houston, Texas, United States, 77006
|United States, Washington
|Swedish Med Ctr
|Seattle, Washington, United States, 98122
|Study Chair:
|Franco Lori
|Study Chair:
|Julianna Lisziewicz
|ClinicalTrials.gov Identifier:
|NCT00002427 History of Changes
|Other Study ID Numbers:
|Study First Received:
|November 2, 1999
|Last Updated:
|June 23, 2005
Keywords provided by NIH AIDS Clinical Trials Information Service:
Dose-Response Relationship, Drug
Drug Therapy, Combination
Reverse Transcriptase Inhibitors
Anti-HIV Agents
Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Slow Virus Diseases
Antineoplastic Agents
Antisickling Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Nucleic Acid Synthesis Inhibitors
Reverse Transcriptase Inhibitors
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Anti-HIV Agents
ClinicalTrials.gov processed this record on September 21, 2017


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My cute son-in-law to be, Peter requests this meal each week when we are menu planning.
When I first went gluten free I really missed having stroganoff. I had used cream of mushroom soup when making it. Now I add fresh mushrooms and thicken the sauce with corn starch and water and my family loves it more than the old version! My favorite pasta to use is quinoa. It has a similar flavor to regular pasta and doesn't fall apart when it's cooked.


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Scot Stephen Gallacher was today named in the Ryder Cup team.
Gallacher, Lee Westwood, Ian Poulter and will be Europe's three wild card picks for the Ryder Cup at Gleneagles, captain Paul McGinley has announced.
Loading article content
That meant there was no place for former world number one Luke Donald as Europe look to claim an eighth win in the last 10 stagings of the biennial contest against the United States on September 26-28.
Westwood has made eight consecutive appearances since making his debut in 1997, winning 21 points from 37 matches.
The 41-year-old finished seventh in the Masters in April and won in Malaysia the following week, but suffered a slump in form until a final round of 63 in the WGC-Bridgestone Invitational in August.
He also shared the lead after the first round of the US PGA Championship before finishing 15th, but failed to advance beyond the first FedEx Cup play-off event.
Gallacher came agonisingly close to securing an automatic place on the team by finishing third in the Italian Open on Sunday, just one shot out of the share of second place he required.
However, McGinley stayed on in Turin after missing the cut and witnessed the Scot card a flawless closing 65 to record his 10th top-10 finish of a qualifying campaign which also saw him retain his Dubai Desert Classic title in February.
Poulter has earned the nickname 'Mr Ryder Cup' and it is hard not to see why. This is the third time he has needed a wild card to make the team, but he has raised his game on every occasion and none more so than at Medinah in 2012.
The 38-year-old won all four of his matches and famously birdied the last five holes alongside Rory McIlroy to beat Jason Dufner and Zach Johnson in the Saturday fourballs. He also beat Webb Simpson in the singles to take his record to an amazing 12 wins from 15 matches.