text:
JIM LEHRER: And finally tonight: federal stimulus money and a school system in upstate New York.
The reporter is John Tulenko of Learning Matters television, which produces education stories for the "NewsHour."
JOHN TULENKO: When Andrew Walker started high school in Rochester, New York, his learning disability made graduation seem unlikely.
ANDREW WALKER, Student: Sometimes, I would be having problems figuring things out. Like, sometimes, I'm reading something and I don't really get it. I would raise my hand. I didn't know what I was doing. I just wasn't learning.
JOHN TULENKO: But a program to train students with special needs for the work force, Rochester's Work Experience Program, put Andrew on track for on-time graduation. Now a senior, he's in small academic classes that meet every morning, and, every afternoon, he earns school credit building this house.
ANDREW WALKER: When it's finished, I could just come back and look at it, like, yes, I did that. That's pretty beautiful, give you a lot of pride.
JOHN TULENKO: But with the economy in recession, Rochester schools began cutting back on programs like this one.
Carleen Meers is the director.
CARLEEN MEERS: I went to look at certain budget lines, and they were markedly different than what I had expected.
JOHN TULENKO: How different?
CARLEEN MEERS: Well, some lines at zero. And that's a little scary when you're looking at a salary line. And I said, this can't be right. This can't be right, because we can't run the program.
JOHN TULENKO: Work Experience wasn't the only program in jeopardy.
Jean-Claude Brizard oversees Rochester's 60 schools and its budget of $700 million.
JEAN-CLAUDE BRIZARD, superintendent, Rochester City Schools: We had a $50 million budget shortfall coming into last fiscal year. At the time, we were predicting about 500 layoffs, which would create a big problem for us as a district. I know, as a city, we couldn't put 500 individuals in the streets.
JOHN TULENKO: Then, in February, the president signed the stimulus, sending $100 billion to the nation's schools to be spent over two years.
U.S. PRESIDENT BARACK OBAMA: Because we know America can't outcompete the world tomorrow if our children are being outeducated today, we're making the largest investment in education in our nation's history.
Stimulus spending in Rochester
JOHN TULENKO: This year, Rochester's share was about $30 million. Here and in most other districts, the bulk of the money restored jobs -- $1.6 million brought back the staff of the Work Experience Program.
CARLEEN MEERS: We have an alternate pathway to graduation. We have an opportunity for students to have choice. That could have been a big loss.
CHILDREN and CONNIE CASTANEDA, Strong Start coordinator: One, two, three, four, five.
CONNIE CASTANEDA: Good job.
JOHN TULENKO: One hundred and sixteen thousand from the stimulus also restored Strong Start, a program serving 757 kindergarten and first-graders.
CONNIE CASTANEDA: I like the way you're doing it.
JOHN TULENKO: Coordinator Connie Castaneda was saved from a layoff.
CONNIE CASTANEDA: Many of our children come in not recognizing basic colors, basic numbers. They don't have basic vocabulary. We catch the problems early on and help the children have an extra boost, so that they will be able to succeed in the years to come.
JOHN TULENKO: Stimulus dollars not only averted cuts. They also helped successful schools, like World of Inquiry, grow.
STUDENT: Greeting for today is to say -- which means hello in Iroquois' language.
JOHN TULENKO: This is the district's most popular elementary school. But over 100 families are on a waiting list to get in.
Roxanne Henry's children got in by lottery.
My kids have opportunities here that I wasn't able to have at such a young age.
JOHN TULENKO: How is your kids' education different?
ROXANNE HENRY: It's so much tactile. They get to feel it. They get to touch it. They get to see it. They get to experience it. Growing up, we mostly read about it. And, here, they're doing it. And it makes such a big difference for them.
Taking students into the community
JOHN TULENKO: World of Inquiry uses a model called expeditionary learning. Here, semester-long research projects take students into the community.
STUDENT: It's like you become an expert on a subject, like wolves. We went to the zoo last year, when I was in fifth grade. You would ask like, are they really mean? Would they eat you after they already ate something?
JEAN-CLAUDE BRIZARD: The school has had tremendous success in literacy and mathematics. Right now, it's number one in science, number one in mathematics in the city of Rochester, despite the fact that it has 70 percent of its kids coming in at or below poverty level.
JOHN TULENKO: To help families lining up to come here, Rochester opened a second school just like it. Ninety-five thousand dollars in stimulus money is going to train the teachers.
How much training will the staff here get?
CHERYL DOBBERTIN, Expeditionary Learning: Three to five years of work intensely with us.
JOHN TULENKO: Cheryl Dobbertin is with Expeditionary Learning. Education nonprofits like hers are seeking out stimulus contracts nationally.
Testing companies are also lining up contracts. Like many districts, one of Rochester's biggest purchases, three-quarters-of-a-million dollars, is for software and tests to track student performance.
Do you really think we need more tests?
JEAN-CLAUDE BRIZARD: Yes. In districts, we have often fragmented databases. I want to be able to easily tie in programs to kids to effectiveness of those programs. It's hard to do that.
JOHN TULENKO: Overall, the stimulus helped Rochester hold the line. Of the 500 layoffs expected, only 12 teachers lost jobs. Nationally, according to the U.S. Department of Education, the stimulus saved some 325,000 education jobs, but that number may drop as economic conditions worsen.
And, in fact, in New York and other states, new budget gaps have emerged, and new cuts are coming. Cities like Rochester are trying to protect programs the stimulus restored.
JEAN-CLAUDE BRIZARD: We're already all working on figuring out how to keep those programs by being more efficient, by looking for other opportunities. We're looking at a staffing reduction over the next three years, but, hopefully, do it through attrition. If we don't do what we have to do, the inevitable is going to face us in about a year or two.
JOHN TULENKO: Already, Rochester has eliminated some 200 positions through retirement and attrition. But it has more scaling-back to do.
Here and elsewhere, stimulus funds run out in two years. If districts cannot come up with replacement money of their own, then programs the stimulus paid for may again disappear.


text:
"I left the duckrabbit course full of enthusiasm and confidence. It must have worked because only my second attempt at gathering material for a photofilm made the front page of the Guardian website." Emma Wigley, Interactive Media Officer, Christian Aid
Next week is a very special duckrabbit workshop, being run in conjunction with QUAD and FORMAT International Photography Festival, in the beautiful market town of Belper, part of a World Heritage area.
The workshop runs from 26th to the 30th November and you have the chance for the photofilms you produce on the course to be exhibited at the FORMAT festival in 2013.
There is one place left….
So if you're a photographer, journalist, audio producer, communications specialist or storyteller looking to learn the art of photofilm production please do get in touch if you'd like to snap it up.
For full details of the workshop visit this page.

subset: commoncrawl


text:
i've added a barracks on top of the medical bay, it's small but i had to do it quick because i was off schedual for a new update.it is on top of the medical bay connected to th main compound by a bridge.i got some orange troops to.
Another thing is i gave the green guys guns because this is a army base and a army -in my world-should have guns.
i added some commandos with multi firing plasma guns (or in english laser chain-guns)
well thats all for now!


text:
Looking to buy AK
I've recently joined here and I've been reading a whole ton of threads already up on the site. I guess I'll start with what my intended uses are. Primarily I really wanted a gun to shoot at the local range, and to have the gun double as home protection (only if it really ever came to that, I live in pretty nice suburbs). I've looked into AKs and I know I don't want a WASR. My budget is around 4-5 hundred, but I will push it to 600 if it is really worth it for the gun. I don't think I have a particular preference in regards to 5.45 or 7.62, but I think I'm probably going to end up with 5.45. I really like the Yugos I've looked at and I really want to find one with a chrome lined barrel. Here's a few I've considered buying... anyone with experience with these I would greatly appreciate the feedback/help!
M72 RPK Sporter 7.62x39 Rifle
AKM74 M74 Sporter Rifle, 5.45x39 Caliber w/ Side Rail. By CAI.
Tantal Sporter Rifle Cal. 5.45x39mm Century Arms
AK 47 Assault Rifle Sale
Bulgarian AK-74 Rifle - 5.45x39 - With 3 Mags #AKAGUN74
Also, are recoil buffers a good idea to put on? Thanks!
Hey, good luck with your purchase. Good decision to go with the AK. I have a Yugo and a WASR-10 and I love them both. The WASR has a chrome lined barrel while the Yugo doesn't but it has a heavier barrel. I've put a bunch of rounds through both and haven't had a single jam or misfire. I can't say which I prefer, maybe the Yugo as it's an underfolder, but I love the look of the wood on my WASR.
Personally, I prefer 7.62x39. Bigger round with a bigger punch. It's pretty close ballistically to the 6.8 - not an exact match, but pretty close. I think you'll find the ammo generally cheaper, and you can fire wolf/tula ammo through it all day. It loves that stuff, and cleaning isn't a big issue with the AK as it breaks down very easy.
One other thing about my Yugo... It has some off size items on it - maybe it's just the underfolder (not sure - I'm not an AK expert). But I know I ordered some addons for it and while they fit the WASR, the Yugo had a gas tube that was longer than standard, and a lower handguard that was longer. I didn't do an exhaustive search, but I wasn't able to find too many accessories for the non standard Yugo.
Good luck!
Thanks! Now I'm looking to get a .22 rifle also for shooting lol. Im looking at some arsenals but theyre a bit over my budget.
Also. how are IOs in quality? they seem ok for the price
The 5.45x 39 is known for it's wounding potential, flatter trajectory, lower recoil and greater accuracy. It's availability is based solely (maybe an exception I don't know of?) on importation.
The AK does not "DOUBLE" well as a "home defense" weapon. It is a powerful rifle that penetrates walls, car doors and many other solid objects. DO NOT USE IT FOR A "HOME DEFENSE" WEAPON, ESPECIALLY IN THE SUBURBS! ! !
How are bulgarian 74s? Correct me if Im wrong, but the WASRs dont come with chromed barrels? The ones Ive looked at I dont remember seeing that. Im hoping to get some feedback on IOs, bulgarians, and polish tantals before I make a run out to the gun shop.
Hornady Manufacturing Company :: Ammunition :: Rifle :: Choose by Caliber :: 5.45X39 :: 5.45X39 60 gr V-MAX Steel Case
This guys have some good prices on AKs & other guns.
Classic Arms Inc.
The only way someone should use it as a home defense weapon is if its their only choice and even then its iffy.if you had to,HP would have to be the round of choice.But a shotgun is the best home defense weapon
I would, however still like to see Winchester, Remington or any other (preferably even lower class) mass commercial manufactures, come up a target/mil-spec line for this cartridge, just to know that the continued supply is available domestically.
But it's a start!
Future availability has always been a major concern for me in regards to the 5.45. All it will take is a stroke of the (Presidential) pen for imports to cease.
The 7.62 has an established manufacturing and fan base. With Winchester, Federal and Remington all making ammo its future availability is more assured.
|All times are GMT. The time now is 11:45 AM.
Copyright ©2000 - 2017, Jelsoft Enterprises Ltd.


text:
Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention (PROSe-ICD)
This study is currently recruiting participants.
Verified August 2017 by Johns Hopkins University
Johns Hopkins University
University of Maryland
Washington Hospital Center
Virginia Commonwealth University
National Heart, Lung, and Blood Institute (NHLBI)
Information provided by (Responsible Party):
Johns Hopkins University
ClinicalTrials.gov Identifier:
First received: August 11, 2008
Last updated: August 10, 2017
Last verified: August 2017
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Biospecimen Retention: Samples With DNA
Show Detailed Description
The overall hypothesis of this study is that subtle interactions between structural (substrate) and functional (trigger) abnormalities of the heart, some of which are genetically-determined, can be used to identify patients at high risk of sudden cardiac death (SCD). Such information may be used to better define patients most likely to benefit from replacement of an internal defibrillator (ICD). The prospective, observational study to enroll, categorize and follow patients who receive an ICD pulse generator replacement for primary prevention of SCD (PROSe-ICD) was established to :
- to gain a better understanding of the biological mechanisms that predispose to SCD
- to develop readily determined clinical, electrocardiographic, genetic and blood protein markers identify patients with an increased risk of dying suddenly
|Heart Failure, Congestive Death, Sudden, Cardiac Arrhythmia Cardiomyopathies
|Study Type:
|Study Design:
|Observational Model: Cohort
Time Perspective: Prospective
|Official Title:
|Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention (PROSe-ICD)
Further study details as provided by Johns Hopkins University:
Primary Outcome Measures:
- Arrhythmic Sudden Death defined as a therapy from the ICD for rapid VT or VF or a ventricular arrhythmia not corrected by the ICD [ Time Frame: 10 years ]
Secondary Outcome Measures:
- All cause mortality, CV mortality, heart transplant, LVAD, and ICD explantation or ICD Disabled [ Time Frame: Total period of observation in the study ]
Biospecimen Retention: Samples With DNA
Whole blood drawn at 6-12 month intervals
|Estimated Enrollment:
|Actual Study Start Date:
|June 2003
|Estimated Study Completion Date:
|March 2020
|Estimated Primary Completion Date:
|March 2020 (Final data collection date for primary outcome measure)
|Ages Eligible for Study:
|18 Years to 85 Years (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Study Population
Patients with ischemic or non-ischemic cardiomyopathy undergoing their first ICD generator replacement for primary prevention.
Inclusion Criteria:
- History of acute MI at least 4 weeks old
- Non-ischemic LV dysfunction for at least 9 months
- Who have an EF < or = to 35%
- Undergone first ERI generator replacement of an FDA-approved ICD for primary prevention of SCD within 12 months of enrollment
Exclusion Criteria:
- ICD generator replacement for secondary prevention
- Inability or unwillingness to provide valid informed consent
- New York Heart Association Class IV heart failure
- Patients with pre-existing Class 1 indications for pacemaker therapy.
- CRT-D devices.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00733590
Please refer to this study by its ClinicalTrials.gov identifier: NCT00733590
|Contact: Barbara Butcher, BSN
|443 287-3472
|United States, District of Columbia
|Washington Hospital Center
|Washington, D.C., District of Columbia, United States, 20010
|Contact: Zayd Eldadah, MD, PhD 202-877-7865 email@example.com
|United States, Maryland
|University of Maryland Medical Center
|Baltimore, Maryland, United States, 21201
|Contact: Stephen R Shorofsky, MD, PhD 800-492-5538 firstname.lastname@example.com
|Johns Hopkins University School of Medicine
|Baltimore, Maryland, United States, 21205
|Contact: Barbara Butcher, BSN 443-287-3472 email@example.com
|Contact: Gordon Tomaselli, MD 410 955-2774 firstname.lastname@example.com
|United States, Virginia
|Virginia Commonwealth University School of Medicine
|Richmond, Virginia, United States, 23298
|Contact: Kenneth Ellenbogen, MD 804-828-7576 email@example.com
Sponsors and Collaborators
Johns Hopkins University
University of Maryland
Washington Hospital Center
Virginia Commonwealth University
National Heart, Lung, and Blood Institute (NHLBI)
|Principal Investigator:
|Gordon F Tomaselli, MD
|Professor of Medicine Johns Hopkins University
More Information
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Johns Hopkins University:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Cheng A, Zhang Y, Blasco-Colmenares E, Dalal D, Butcher B, Norgard S, Eldadah Z, Ellenbogen KA, Dickfeld T, Spragg DD, Marine JE, Guallar E, Tomaselli GF. Protein biomarkers identify patients unlikely to benefit from primary prevention implantable cardioverter defibrillators: findings from the Prospective Observational Study of Implantable Cardioverter Defibrillators (PROSE-ICD). Circ Arrhythm Electrophysiol. 2014 Dec;7(6):1084-91. doi: 10.1161/CIRCEP.113.001705. Epub 2014 Oct 1.
Cheng A, Dalal D, Butcher B, Norgard S, Zhang Y, Dickfeld T, Eldadah ZA, Ellenbogen KA, Guallar E, Tomaselli GF. Prospective observational study of implantable cardioverter-defibrillators in primary prevention of sudden cardiac death: study design and cohort description. J Am Heart Assoc. 2013 Feb 22;2(1):e000083. doi: 10.1161/JAHA.112.000083.
Tereshchenko LG, Cheng A, Fetics BJ, Butcher B, Marine JE, Spragg DD, Sinha S, Dalal D, Calkins H, Tomaselli GF, Berger RD. A new electrocardiogram marker to identify patients at low risk for ventricular tachyarrhythmias: sum magnitude of the absolute QRST integral. J Electrocardiol. 2011 Mar-Apr;44(2):208-16. doi: 10.1016/j.jelectrocard.2010.08.012. Epub 2010 Nov 20.
Stempniewicz P, Cheng A, Connolly A, Wang XY, Calkins H, Tomaselli GF, Berger RD, Tereshchenko LG. Appropriate and inappropriate electrical therapies delivered by an implantable cardioverter-defibrillator: effect on intracardiac electrogram. J Cardiovasc Electrophysiol. 2011 May;22(5):554-60. doi: 10.1111/j.1540-8167.2010.01958.x. Epub 2010 Nov 18.
|Responsible Party:
|Johns Hopkins University
|ClinicalTrials.gov Identifier:
|NCT00733590 History of Changes
|Other Study ID Numbers:
5R01HL091062 ( U.S. NIH Grant/Contract )
|Study First Received:
|August 11, 2008
|Last Updated:
|August 10, 2017
Keywords provided by Johns Hopkins University:
defibrillator, implanted
electrophysiological study
Additional relevant MeSH terms:
Heart Failure
Death, Sudden, Cardiac
Death, Sudden
Heart Diseases
Cardiovascular Diseases
Pathologic Processes
Heart Arrest
ClinicalTrials.gov processed this record on September 21, 2017


text:
The Opposition Leader promised this week that every Australian household would receive a free floppy disk drive and monochrome monitor under an Abbott-led government.
Launching the Coalition's long awaited resptonse to the government's National Broadband Network program, Mr Abbott denied that providing a floppy drive and monitor without the computing box to plug them into would leave Australian households with a second best solution.
"Second best is the sort of Labor extravagance that is bankrupting this country," he said. "If people want more they can easily spend a few thousand dollars to upgrade to a very fast 386 or even 486 computing box."
When asked by Leigh Sales what a '386 computing box' was, he admitted he wasn't "across the brief" but, "Here's everyone's favourite! The internet's Malcolm Turnbull!"
Mr Turnbull immediately deflected criticism of the lack of a computing box, by pointing out that the monochrome monitor was not some old fashioned TRS 80 green screen, but rather a much cooler-looking mandarin-hued model, which was more than adequate for most people's needs.
"WordStar looks smashing on this," he said.
When asked how much input he'd had into the final policy he smiled and insisted it was all Mr Abbott's work, "All of it. Nothing to do with me. Make sure you write that down."
The policy launch, which took place in a futuristic studio setting, and was attended by dozens of the nation's top technology writers was an accident, sources close to Mr Abbott admitted later.
"It was supposed to be just Tony and Dennis Shanahan," the spokesman said. "Dennis can't even read his emails. A secretary types them out for him. We thought he'd be good for us."
Instead, Mr Abbott had to repeatedly defer to his communications spokesman to handle the demanding technical details of the policy. Mr Turnbull admitted the whole thing was "really just a bag of dicks", but urged the assembled journalists to take note of how much more impressive he looked than his leader when talking about this stuff.
Mr Abbott, repeatedly trying to plug one of the demo model floppy drives into a power point said he "wasn't really a tech head".
Reaction to the announcement was frothingly positive in the News Limited press, where news that the NBN would not be able to compete with Telstra was hailed as 'excellent' by major shareholder and noted Sith Lord, Rupert Murdoch.


text:
Canadian Dollar Declines on China Before Rate Decision
The Canadian dollar traded at almost its lowest in eight months versus its U.S. counterpart as crude oil, Canada's largest export, dropped to its weakest level in 10 weeks before the central bank's interest-rate decision.
The currency fell against the majority of its 16 most- traded peers after a report showed companies in China, Canada's third-largest destination for exports, are expanding at a slower-than-forecast pace. The so-called loonie pared losses as stocks rose on improved risk appetite. The Bank of Canada is forecast to hold its interest rate steady when it meets March 6.
"If the statements were to sound increasingly dovish, that tends to see the loonie come under renewed pressure," Joe Manimbo, market analyst for Western Union Business Solutions, a unit of Western Union Co. (WU), said of the central bank in a phone interview from Washington. "I would suspect a sideways Canadian dollar in the run-up to the Bank of Canada meeting."
The loonie, as the Canadian dollar is known for the image of the aquatic bird on the C$1 coin, fell 0.1 percent to C$1.0273 per U.S. dollar at 5 p.m. in Toronto after declining as much as 0.4 percent. It touched C$1.0342 on March 1, its lowest point since June 29. One loonie buys 97.34 U.S. cents.
Canada's benchmark 10-year government bond fell, with yields rising one basis point, or 0.01 percentage point, to 1.81 percent. The 2.75 percent security maturing in June 2022 fell seven cents to C$108.01. The Standard & Poor's 500 Index of stocks rose 0.5 percent after falling 0.4 percent.
Crude Drops
"Traders are finding it easy to sell the Canadian dollar on any negative news or any geopolitical hiccup," Adam Button, a currency analyst at Forexlive.com, said by phone from Montreal. "And when there is good news, the Canadian dollar rallies are minimal."
Canada's dollar extended losses as futures on crude oil fell as much as 1.5 percent to $89.33 a barrel in New York, the lowest since Dec. 26, before trading at $90.28. S&P's GSCI Index of 24 raw materials slid for a fifth day, declining 0.4 percent.
Western Canada Select, the benchmark for oil-sands bitumen, traded at a discount of $27 to U.S. West Texas Intermediate, close to a three week high and above the 200-day moving average of $23.30.
The loonie declined earlier as China's non-manufacturing Purchasing Managers' Index fell to 54.5 in February from 56.2 in January, the Beijing-based National Bureau of Statistics and China Federation of Logistics and Purchasing said in a statement yesterday. A reading above 50 indicates expansion.
Interest Rate
Bank of Canada officials have held the benchmark interest rate at 1 percent since September 2010 to support the economy. Trading in overnight index swaps today showed investors have priced in as much as 17 basis points of easing by the central bank by its December meeting, data compiled by Bloomberg showed. A week ago, they had priced in two points of easing.
Central bank Governor Mark Carney said Feb. 25 some of the risks to the economy he highlighted last month are materializing and policy makers are sticking to their assessment that interest-rate increases have become less urgent than they had anticipated.
Future traders reversed wagers the loonie will rise against its U.S. counterpart, betting it will fall for the first time in eight months, figures from the Washington-based Commodity Futures Trading Commission show.
Hedge funds and other large speculators had 21,433 more bets the Canadian dollar would fall than bets it would gain, so- called net shorts, on Feb. 26, compared with 19,379 more bets it would gain, or net-longs, a week earlier.
Sequester Effect
"I expect data out of North America, particularly the U.S., to be more positive, more risk-friendly, and I don't necessarily see the U.S. dollar appreciating on the back of that because of the sequester," said Dean Popplewell, head analyst in Toronto at the online currency-trading firm Oanda Corp., by phone from Toronto. "So that could give the Canadian dollar a risk proxy support, despite a less hawkish Bank of Canada."
Automatic across-the-board cuts of $85 billion to the U.S. federal government's budget, known as the sequester, went into effect March 1, with presidential aides and congressional leaders signaling the reductions would continue for weeks, possibly months.
Both Canada and the U.S., the country's largest trading partner, are forecast to have added jobs in February when they release employment data on March 8, according to economists surveyed by Bloomberg.
Canada added 8,000 jobs last month from a net job loss in January, according to a Bloomberg survey of 18 economists. The U.S. increased by 160,000 new jobs, according to a separate survey of 70 economists.
Canada's dollar has fallen 1.2 percent this year among 10 developed nation currencies tracked by the Bloomberg Correlation-Weighted Index. The U.S. dollar has gained 2.7 percent and the euro is up 1.3 percent.
To contact the reporters on this story: Taylor Tepper in New York at firstname.lastname@example.com; Ari Altstedter in Toronto at email@example.com
To contact the editor responsible for this story: Dave Liedtka at email@example.com


text:
The Golden Spider (2012) – 176 pages;
$3.99 Kindle/$7.99 paper
A fantasy/science fiction novel created primarily for children aged 9-14, The Golden Spider, rich in story and vocabulary, is also a good read for older kids and adults who like this genre. The cosmic battle of good versus evil and life against death plays out in the adventures of Jeremy Taylor, his friends Sandy and Zack, his wise and telepathic cat, and the golden alien who leads them on a cosmic journey. Together, they battle a wily and titanic dragon in search of a sacred book that contains the key to Earth's salvation.
Morning and Begin Again (2012) – 186 pages;
$9 Kindle/$13 paper
In Morning and Begin Again, the poems are grouped according to life's great themes: childhood, love, transience, depression, nature, places lived in and visited, and remembrances of loved ones lost. The overall theme is death and rebirth, in both inner and outer life. These poems are not obscure or abstract conceptual puzzles, but rather are grounded in remembered and imagined events and tell stories about living: its depths and shallows, whelms and hollows. The goal is, through image and sound, to involve and move readers, to power and intensify their lives by enabling them to share in the poet's most potent and fascinating experiences.
Animal Songs (2010) – 140 pages; $14.00
Exploring animals as creatures in their own right and as metaphors for the human experience, these 71 poems range in tone from foreboding to comical. With over 50 original illustrations by an accomplished artist and a full-color original cover, Animal Songs will set your mind humming with ideas and images and will make an appealing gift for lovers of animals and poetry alike.
Watch Dan read from Animal Songs. (Video)
The Pitch is on the Way: Poems About Baseball and Life (2008) – 112 pages; $13.00
How does it feel to love, play, and watch baseball as a kid and as an adult? After a Foreword by Peter Magowan, ex-President of the SF Giants, 50 poems and 21 professional illustrations depict the players and the plays; the challenges of each position; the ups and downs of hitting and fielding; the role of support staff like umpires and coaches; and baseball's fabled history.
Hear Garrison Keillor read the poem "Child's Play" from "The Pitch is on the Way" on The Writer's Almanac program from August 30, 2012.
A Family Album (2006) – 144 pages; $17.00
Darkly humorous and sharply perceptive poems describe the joys and sorrows of a second-generation Jewish childhood with perfectionist parents and a schizophrenic child. Verbal portraits of eccentric relatives abound in this tale of the losses and small triumphs of a family under siege by mental illness. Includes 23 family album photos and expressive graphic designs and 2 CDs of the author (a trained actor) reading all the poems.


text:
My application does not use any transactions (other than the implicit per statement ones that must exist), but I think I did edit some functions in pgadmin around that time so it may be that bug or something similar/related. I didn't bother to upgrade to 8.1.4 because I thought it was just a security fix that didn't apply to me. I'll upgrade tonight during off hours. ----- Original Message ----- From: "Tom Lane" <tgl(at)sss(dot)pgh(dot)pa(dot)us> To: "Cstdenis" <cstdenis(at)fanart-central(dot)net> Cc: <pgsql-bugs(at)postgresql(dot)org> Sent: Friday, May 26, 2006 8:05 PM Subject: Re: [BUGS] BUG #2458: Postgresql crash > "Cstdenis" <cstdenis(at)fanart-central(dot)net> writes: > > [ SIGSEGV in plpgsql_xact_cb ] > > I think this is probably an instance of the bug patched here: > http://archives.postgresql.org/pgsql-committers/2006-03/msg00022.php > > If you're certain that your applications never redefine a plpgsql > function that might be in active use, then we might need to look > harder. Otherwise, please update to 8.1.4 and see if the problem > recurs ... > > regards, tom lane >
Next: From: Volkan YAZICI Date: 2006-05-27 08:03:45 Subject: Strange random() Correlation Previous: From: Tom Lane Date: 2006-05-27 03:05:52 Subject: Re: BUG #2458: Postgresql crash


text:
Transformation Bill Deal-Making Comes Down to the Wire
June 17, 2011 -- In the final weeks of the Oregon legislative session, negotiations on a monumental bill to transform the Oregon Health Plan have largely taken place behind closed doors.
House Bill 3650 was moved to the Joint Ways and Means Committee two weeks ago before all the amendments had been ironed out. Rep. Tim Freeman (R-Roseburg) said lawmakers were still working on three aspects of the bill in recent weeks.
The bill aims to consolidate the roughly 40 managed care organizations that currently administer the Oregon Health Plan into regional organizations that can more effectivity manage chronic conditions and deliver preventive care. Those efforts are estimated to save roughly $700 million in total funds – $240 million in general fund dollars – by the end of the next biennium.
Reportedly still holding up the legislation is a controversial aspect related to collective bargaining for home health workers, which are expected to play an important role in the newly revamped Medicaid program.
The Service Employees International Union has lobbied strongly for language in the bill that would allow the union to organize home health workers as a single unit, while Republicans have argued strongly that it should be removed. A compromise reportedly would give those workers the option, but not require collective bargaining.
As the bill now awaits approval from a subcommittee of the Joint Ways and Means Committee, sources say this union issue could be the last piece that needs agreement.
The issues recently finalized include a section related to Indian Health Services in order to allow tribal health center to participate in newly formed regional coordinated care organizations, but not make that a requirement.
"The intent is to hold them harmless," Freeman said. "We wanted to make sure we weren't somehow disenfranchising them or make sure we weren't over emphasizing their need to be involved."
Lawmakers also solidified an aspect of the bill related to the governance of the new coordinated care organizations.
"The majority of the board has to be the ones who are at financial risk, along with a strong voice for consumers on that board," said Sen. Alan Bates (D-Ashland).
One piece of the bill that would have instituted a drug formulary for mental health drugs under the state Medicaid program was eliminated. That provision was estimated to save around $7 million, while others thought it could increase costs due to unexpected hospitalizations possibly from drug interactions.
"Broadly speaking the bill will do what we want it to," Bates said. "At a certain point you have to say the basis of the bill is there. Most of this doesn't take place until February. We can tweak it then."
The massive piece of legislation is still facing strong criticism that the estimated savings will not be realized next biennium.
Freeman said he doesn't view this as savings. "There will be less money to provide the services, but this transformation bill will allow those people in the community who provide those services to manage those cuts better and coordinate their efforts," Freeman said. "The intent is to better coordinate care with less money."
For related stories click here.


text:
Two weekends ago I ran a half marathon. I paced a friend for most of it, took off at the very end, and finished in 1:42 and change. It felt easy, like I was trotting along. I must not be in as terrible shape as I thought. I have quite a few photos from the race, so I will try to write a race report. I definitely have time right now!
I caught some virus and have been sick for over a week now. I am supposed to start antibiotics today or tomorrow since my sinuses aren't clearing. I missed two days of work, last Friday and this past Monday, and now I am home again because now I have an eye infection. It's gross. I haven't even felt like running for a while, but I am thinking about it still because I bought more race photos and I am about to sign up for another race or two this summer.
I got a message from the folks at marathonfoto saying my photos from Boston 2012 were going offline soon. I went ahead and bought them since this was such a special race for me. Race Report here: No Picnic in Boston…
I went ahead and bought them all. Sometimes race photos are worth it. This one, taken somewhere towards the finish I believe, is my favorite:
At the start:
At the halfway mark I believe:
After finishing:
I was so proud putting that medal around my neck – or did the volunteer do it for me? I can't remember. I was dazed and hot and happy and exhausted.
I struggled to get to Boston 2012. It was my second marathon and I ended up with a stress fracture that only healed up in time to let me start training for the April race around the end of December/beginning of January. I also ended up dealing with Mononucleosis (Epstein Barr Virus) during training, which made running more difficult. I remember going out for a 17 mile run and having Matt come look for me on a bicycle because I was so slow. I literally laid down in the driveway after I was done.
But thanks to my family (Matt and my dad would take turns running or riding a bike with me while I ran) and my friends, I made it to the start line in Hopkinton, only to be greeted with a near 90 degree race day. It was crazy. I remember walking to the start line from Athlete's Village with grim determination and a healthy dose of fear I tried to bury. The rest of the runners were as determined as I was to finish, but we all knew (well most of us knew) that it wasn't going to be our best finish time and very risky to even attempt running a marathon that day. The director cautioned us to slow way down and take extra fluids. Be careful, run safe. Most of us that took that advice made it to the finish. We were helped on our way by each other and encouragement and support from the spectators, who set up sprinklers, handed out water and ice, fed us orange slices, popsicles, and otter pops. Convenience stores brought out coconut water and gatorade. The fire departments set up mist tents. I have never felt so much love and support in a race as I did during the 2012 Boston Marathon. I have never cried in a marathon, but I cried twice that day: once at the start, once at the finish.
It meant so much to be there and it meant so much that the people of Boston wanted me and the other runners there. I will never forget the support I had to get there and to get through the race. The people along the course bought things with their own money, gave their time to help us that day. They didn't have to, but they wanted to and they did. I was so grateful for their kindness. I am still grateful.
That is why I was incredibly sad and angry about what happened in Boston 2013. I can't talk or write about it much, except to say that it was horrible and I was afraid, sad, and angry all at once. I will never make sense of what happened because it is senseless, evil and I will never understand.
I do understand, more than ever, that it is my family and friends who make my life better. I don't know where I would be without them. And the kindness and willingness of strangers to help that will make this world better. I would have never made my dream a reality without my family, friends, and good people along the Boston marathon course.


text:
Click song titles to play/pause audio
Philip Glass's haunting and melancholic Quartet No. 2, shot on an appropriately bleak day in Chicago by Hamid Bendaas and Michael Hwang.
"Serious Business" features world premieres by Sky Macklay, David Reminick, and Chris Fisher-Lochhead...and a not-world-premiere by Josef Haydn.
Classical music can always benefit from a dose of the funny.
Each piece on Serious Business looks at humor in music from a different angle – not necessarily with the goal of making the listener laugh, but as a sophisticated subject to be explored (without taking that subject too seriously).
The music of Astor Piazzolla is well known to North American audiences, but what came after the Tango Nuevo revolution?
Spektral Quartet teamed up with accordion and bandoneon virtuoso Julien Labro to uncover exactly that with the blistering album, From This Point Forward.
The Spektral Quartet's debut, CHAMBERS is a time capsule of Chicago's vibrant new-music scene from 2010-13. From exquisite microtonal harmonies to textures at the edge of the audible to hyper-kinetic guitar-pick strumming, CHAMBERS leads listeners through six rooms, each filled with a distinct voice and unique acoustic.


text:
Dirk Nowitzki scored 24 points and the Dallas Mavericks rallied in the fourth quarter to beat the Los Angeles Clippers 106-100 Wednesday, improving the NBA's best road record to 27-10 with their fifth straight win.
Nowitzki missed the first of two free throws midway through the period, snapping his streak of 74 in a row - longest in the league this season - that dated to the fourth quarter against Indiana on March 4.
He got ample chance to make up for it, when Mo Williams was hit with consecutive technicals and ejected with 6:02 remaining and Nowitzki made both. Williams scored 19 points, making all nine of his free throws.
Blake Griffin had 25 points and 17 rebounds for his 57th double-double of the season. He came off the bench in the fourth to erase most of the Clippers' 16-point deficit, scoring six points in an 11-0 run that left them trailing 96-91 with 3:20 left.
But Jose Barea answered with five straight points to push the Mavs' lead to 101-91. He finished with 22 points. Jason Kidd had 10 assists.
Earlier in the fourth, Nowitzki scored six points - four on free throws - in the Mavs' 13-1 run that produced their first double-digit lead of the game, 96-80. Nowitzki missed another free throw in the final minute.
Eric Gordon added 15 points for the Clippers, who've lost nine in a row and 15 of their last 16 to the Mavs. Dallas has won its last five road games against the Clippers.
Down by six with 7 seconds left, Gordon airballed a 3-point attempt.
The teams traded leads in a tight third quarter. With the Clippers leading by one, the Mavs outscored them 12-6 to lead 75-70 going into the fourth. Peja Stojakovic and Brian Cardinal hit 3-pointers in the spurt.
The Clippers blew a 13-point lead in the first, when Williams scored their first nine points. Dallas tied the game at 44-all late in the second and scored the final two baskets to lead 48-46 at the break.
Notes: The Mavs improved to 13-1 against the Pacific Division, with their only loss to the Lakers, who await on Thursday. ... The Clippers' franchise record for double-doubles is 69 set by Bob McAdoo in 1974-75, when the team was in Buffalo. ... The crowd of 19,060 was the Clippers' 16th sellout of the season.


text:
Nokia blesses Google Talk - report
Tablet seeks users
A device that no one uses will feature a chat service with no users, the Wall Street Journal reports today.
The device is Nokia's next Wi-Fi tablet, and the chat client is Google Talk, the IM service which is capable of making SIP voice calls. To be announced Tuesday, the hardware will be Nokia's successor to the Linux-based 770, which crept onto the market late last year. It's designed as a mobile web browsing device, rather than a phone or a PDA, that fits perfectly into a pair of speedos.
VoIP was always on the roadmap for 2006, Nokia said a year ago when it announced the 770. It's much more of a significant win, however, for Google, which at last finds an OEM to take its neglected and late-to-market IM chat client.
The 770 has found an enthusiastic, but very limited, audience of Debian developers, many of whom have received one from Nokia. But after the initial rush of enthusiasm, we're still not sure anyone has bought one. Or even whether that was intention. Nokia executives hoped that ISPs in the competitive European broadband markets would offer 770s to punters.
For now, Nokia will be pleased it has been well received by the Linux community. And we're just delighted that someone has squeezed a server operating system into a consumer device designed to display a few angle brackets.
More significant than the news with the magic 'G' word in it, is the disclosure that the price point for the Nokia 770's successor remains the same at $399.
That's $100 more than a Wi-Fi capable Palm TX. It's brutal out there. ®


text:
Goldman Sachs Publishes Dodd-Frank Act Stress Test Summary
The Goldman Sachs Group, Inc. (NYSE: GS) (Company) today announced that
as required under the Dodd-Frank Wall Street Reform and Consumer
Protection Act (DFA), the Company and Goldman Sachs Bank USA have
published a summary of the results of the DFA stress tests performed by
each of them under the Federal Reserve's severely adverse scenario. The
results are available in the Investor Relations section of our web site, www.gs.com/shareholders.
The Goldman Sachs Group, Inc. is a leading global investment banking,
securities and investment management firm that provides a wide range of
financial services to a substantial and diversified client base that
includes corporations, financial institutions, governments and
high-net-worth individuals. Founded in 1869, the firm is headquartered
Posted-In: News Guidance Contracts Management Global


text: I am running some shower control valve lines and using Pex for the first time. My question concerns how to properly secure pex lines to a shower control valve. One option would be to secure the vertical pex lines to the framing members to a pex T with a horizontal pex line then running to the valve. The other option would just secure the vertical pex partially to the framing member and then bend the line and attach it to the valve. Is one option better than the other? Does it matter?


text:
So take this night,
Wrap it around me like a sheet.
I know I'm not forgiven
But I need a place to sleep...
Black Lab
Any proper orthochronous Lorentz transformation (including ordinary rotations and relativistic boosts) can be represented by
and Q* is the transposed conjugate of Q. The coefficients a,b,c,d of Q are allowed to be complex numbers, normalized so that ad - bc = 1. Just to be explicit, this implies that if we define
then the Lorentz transformation (1) is
Two observers at the same point in spacetime but with different orientations and velocities will "see" incoming light rays arriving from different relative directions with respect to their own frames of reference, due partly to ordinary rotation, and partly to the aberration effect described in the previous section. This leads to the remarkable fact that the combined effect of any proper orthochronous (and homogeneous) Lorentz transformation on the incidence angles of light rays at a point corresponds precisely to the effect of a particular linear fractional transformation on the Riemann sphere via ordinary stereographic projection from the extended complex plane. The latter is illustrated below:
Roger Penrose described this as "the first step of a powerful correspondence between the spacetime geometry of relativity and the holomorphic geometry of complex spaces". The complex number p in the extended complex plane is identified with the point p' on the unit sphere that is struck by a line from the "North Pole" through p. In this way we can identify each complex number uniquely with a point on the sphere, and vice versa. (The North Pole is identified with the "point at infinity" of the extended complex plane, for completeness.)
Relative to an observer located at the center of the Riemann sphere, each point of the sphere lies in a certain direction, and these directions can be identified with the directions of incoming light rays at a point in spacetime. If we apply a Lorentz transformation of the form (1) to this observer, specified by the four complex coefficients a,b,c,d, the resulting change in the directions of the incoming rays of light is given exactly by applying the linear fractional transformation (also known as a Mobius transformation)
to the points of the extended complex plane. Of course, our normalization ad - bc = 1 implies the two conditions
so of the eight coefficients needed to specify the four complex numbers a,b,c,d, these two constraints reduce the degrees of freedom to six, which is precisely the number of degrees of freedom of Lorentz transformations (namely, three velocity components vx,vy,vz, and three angular specifications for the longitude and latitude of our line of sight and orientation about that line).
To illustrate this correspondence, first consider the "identity" Mobius transformation w ® w. In this case we have
so our Lorentz transformation reduces to t' = t, x' = x, y' = y, z' = z as expected. None of the points move on the complex plane, so none move on the Riemann sphere under stereographic projection, and nothing changes in the sky's appearance. Now let's consider the Mobius transformation w ® -1/w. In this case we have
and so the corresponding Lorentz transformation is t' = t, x' = -x, y' = y, z' = -z . Thus the x and z coordinates have been reflected. This is certainly a proper orthochronous Lorentz transformation, because the determinant is +1 and the coefficient of t is positive. But does reflecting the x and z coordinates agree with the stereographic effect on the Riemann sphere of the transformation w ® -1/w? Note that the point w = r + 0i maps to -1/r + 0i. There's a nice little geometric demonstration that the stereographic projections of these points have coordinates (x,0,z) and (-x,0,-z) respectively, noting that the two projection lines have negative inverse slopes and so are perpendicular in the xz plane, which implies that they must strike the sphere on a common diameter (by Pythagoras' theorem). A similar analysis shows that points off the real axis with projected coordinates (x,y,z) in general map to points with projections (-x,y,-z) points.
The two examples just covered were both trivial in the sense that they left t unchanged. For a more interesting example, consider the Mobius transformation w ® w + p, which corresponds to the Lorentz transformation
If we denote our spacetime coordinates by the column vector X with components x0 = t, x1 = x, x2 = y, x3 = z, then the transformation can be written as Xʹ = LX where
To analyze this transformation, note first that we can decompose any Lorentz transformation into the product of a simple boost and a simple rotation. Let v1, v2, v3 denote the components of the velocity of the origin of the Xʹ coordinate system in terms of the X coordinates, let v denote the magnitude v = (v12 + v22 + v32)1/2, and let g denote the "boost factor" γ = (1−v2)−1/2. By inverting L and examining the expressions for x, y, z given xʹ = yʹ = zʹ = 0, we find that
Any matrix representing a transformation from the X coordinates to a system at rest with the Xʹ coordinates must have these values as the top row. In addition, if we want the velocity of the origin of the X coordinates to have the components –v1, −v2, −v3 relative to the transformed coordinates, then the first column of the transformation matrix must have the same values as the first row. The L matrix does not satisfy this latter requirement. Therefore, if we define a "pure boost" as a Lorentz transformation between two inertial coordinate systems such that the two see each other moving with velocities (v1,v2,v3) and (-v1,-v2,-v3) respectively, then the L transformation is not a pure boost.
Still, we can clearly apply a pure boost from X to a system of coordinates whose spatial origin always coincides with the spatial origin of Xʹ, so this system can differ from Xʹ only by a pure spatial rotation. In general, if we spatially rotate X so the motion is along the x axis, apply a simple pure boost, and then spatially rotate back, we can construct a pure boost to a state of motion moving with any given velocity v1,v2,v3. This leads to the unique pure boost
where Q = (g-1)/v2. Equating the elements of the top row with those of L, we can express the velocity components in terms of the Mobius parameter p
Thus we can write the pure boost part of L as
We know that our Lorentz transformation L can be written as this pure boost B followed by a pure spatial rotation R, i.e., L = RB, so we can compute the rotation R = LB−1, which in this case gives
This represents a rotation about the yʹ axis through an angle of
The correspondence between the coefficients of the Mobius transformation and the Lorentz transformation described above assumes stereographic projection from the North pole to the equatorial plane. If instead we project from the North Pole of the Riemann sphere to a complex plane parallel to (but not necessarily on) the equator, and if the North Pole is at a height h above the plane, then every point in the plane is a factor of h further away from the origin than in the case of equatorial projection (h=1). Therefore, the transformation w ® (aw+b)/(cw+d) on the equatorial plane maps to the transformation is w ® (a'w+b')/(c'w+d') where
It's also worth noting that the instantaneous aberration observed by an accelerating observer does not differ from that observed by a momentarily co-moving inertial observer. We're referring here to the null (light-like) rays incident on a point of zero extent, so this is not like a finite spinning body whose outer edges have significant velocities relative to their centers. We're just referring to different coordinate systems whose origins coincide at a given point in spacetime, and describing how the light rays pass through that point in terms of the different coordinate systems at that instant. In this context the acceleration (or spinning) of the systems make no difference to the answer. In other words, as long as our inertial coordinate system has the same velocity and orientation as the (ideal point-like) observer at the moment of the observation, it doesn't matter if the observer is in the process of changing his orientation or velocity. (This is a corollary of the "clock hypothesis" of special relativity, which asserts that a traveler's time dilation at a given instant depends only on his velocity and not his acceleration at that instant.)
In general, the effect of the finite Mobius transformation
for complex constants a,b,c,d can be classified according to the value of the "squared trace"
We call this the "conjugacy parameter", because two linear fractional transformations are conjugate if and only if they have the same value of s. The different kinds of transformations are listed below:
0 £ s < 4 elliptic
s = 4 parabolic
s > 4 hyperbolic
s < 0 or not real loxodromic
We note that pure rotations (a special case of elliptic transformations) have the form
where an overbar denotes complex conjugation.
Iteration of the function f(z) generates the discrete sequence f1(z) = f(z), f2(z) = f(f(z)), f3(z) = f(f(f(z))), and so on for all fn(z) where n is a positive integer. It's not difficult to show that these iterates are cyclical with a period m if and only if s = 4cos(2kp/m)2 for some integer k. We can also give an explicit expression for fp(z) where p is any complex number. This effectively gives us the infinitesimal generator of the finite transformation. To accomplish this we must (in general) first map the discrete generator f(z) to a domain in which it has some convenient exponential form, then apply the pth-order transformation, and then map back to the original domain. There are several cases to consider, depending on the character of the discrete generator.
In the degenerate case when ad = bc with c ¹ 0, the pth iterate of f(z) is simply the constant fp(z) = a/c. On the other hand, if c = 0 and a = d ¹ 0, then fp(z) = z + (b/d)p. The third case is with c = 0 and a ¹ d. The pth iterate of f(z) in this case is
Notice that the second and third cases are really linear transformations, since c = 0. The fourth case is with c ¹ 0 and (a+d)2/(ad-bc) = 4, which leads to the following closed form expression for the pth iterate
This corresponds to the case when the two fixed points of the Mobius transformation are co-incident. In this "parabolic" case, if a+d = 0 then the Mobius transformation reduces to the first case with ad-bc = 0.
Finally, in the most general case we have c ¹ 0 and (a+d)2 /(ad-bc) ¹ 4, and the pth iterate of f(z) is given by
This is the general case with two distinct fixed points. (If a+d = 0 then s = 0 and K = -1.) The parameters α and β are the coefficients of the linear transformation that maps the real axis to the locus of points with real part equal to 1/2. Notice that the pth composition of f satisfies the relation
so we have
Thus , which shows that f(z) is conjugate to the simple function Kz. Since α+β is the complex conjugate of β, we see that h(z) can be expressed as
This enables us to express the pth composition of any linear fractional transformation with two fixed points, and therefore any corresponding Lorentz transformation, in the form
This shows that there is a particular oriented frame of reference (i.e., an orientation as well as velocity boost) represented by h(z), with respect to which the relation between the oriented frames z and f(z) is purely exponential.


text:
They've fought a volcano to tour North America, so the very least you could do is turn out to hear first wave British shoegaze legends Chapterhouse bend nature to its will with howling guitars. Chapterhouse begins its brief journey on Friday, October 1. It may prove to be the group's final act.
Because fame is fickle, especially in Great Britain, Chapterhouse was swept up in the early '90s as darlings of "the scene that celebrates itself" before being unceremoniously dismissed as pointy-headed navel contemplators by a hyperbolic media suddenly in thrall to Britpop.
History has been far kinder to Chapterhouse, whose legacy has survived thanks to a stellar debut (Whirlpool), a genre-defying sophomore effort (Blood Music), and an expansive career retrospective which left its fans longing for more. With their North American tour looming, Andrew Sherriff and Stephen Patman took the time to speak to PopMatters.
"Bar another volcano, we'll be there," says Sherriff, joking about the eruption of Eyjafjallajökull, which left Patman stranded in Japan back in May just as the band was meant to begin the tour it is finally able to undertake.
"Although we were psyched up and really wanted to come out and do the shows, we were also quite tired, because there was an intense period where we had the Japan tour and the Scala gig in London as well," Sherriff said. "It was quite full on, and in a way we had more time to be relaxed for this tour. We've been taking full day rehearsals rather than evening rehearsals, and we feel that we're in a better state to cope with this now."


text:
New Drives..Time to backup
Would you partition at all with this method? For instance, on your boot drive, would you have C: Window OS D: programs Then when this is mirrored onto the drive which has the scratch disk would that have a partition for the scratch disk, a partition for the Windows OS mirror and a partition for the programs mirror?? If you used Raid 1 to do the mirroring, could you still assign the scratch disk to "just" the second drive and have it separate from the Raid array?
Scott Eaton wrote:
Use Acronis (or another product) to keep a periodic mirror image of
your c: drive on the drive you currently you use for your scratch
disk. Given they are the same size, I can assume they are identical
in other respects, and the scratch disk should make an ideal
back-up drive.
This way if your boot drive takes a dive, or the OS gets corrupted,
or you get hit by some serious trojans or malware (poor security
advice in this forum makes that a high probability) then all you
have to do is switch the cable on your HD's, and you are back in
business. No screwing around with DOS booters, corrupted CD images,
non compliant USB chipsets etc. I've imaged thousands of systems
from Network boot disks I've built myself, but now my preferred
back-up method is simply to keep a cloned HD in the machine, and
clone it weekly because tools like Paragon and I believe Acronis
can do live system backups while the OS is up. I now do this with
all my critical system servers as well. If something goes wrong
with anything on the C: drive, software or hardware, I just
switch to the cloned drive and everything is good.
Use your 320gig as a general data dump, and get as much data off
your C: drive as possible. If your C: drive is kept clean and only
hosts the OS and program files, it will likely not exceed 25% of
utilization and you can keep your scratch disk there with no
performance penalty. So, you solve two problems for the price of
Old Crow, Yukon Territory
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|.....the ROYAL LOTUS 2017/08/25-NEW YORK..... by Chiwat
from Wild flowers
|Coffee and Mango cake by clicker88
from Another cup of coffee


text: Warning: This is extremely TMI, so those with delicate constitutions may prefer not to continue reading. Bloomberg News has an excerpt of Sheryl Weinstein's book—Madoff's Other Secret— about her alleged affair with Ponzi schemer Bernard Madoff. Weinstein writes, "Bernie had a very small penis. Not only was it on the short side, it was small in circumference. That he was now pointing it out to me was telling. It clearly caused him great angst. I wanted to be careful how I responded. Men and their penises have a strange and unique relationship...[However] I liked this man and didn't want to emasculate him. His tiny penis hadn't prevented me from climaxing...On the bright side, oral sex would be a breeze." Way to look on the bright side! Weinstein met Madoff while handling finances for the Hadassah organization (she invested millions of the group's money with Madoff). Madoff's lawyer said Weinstein's claims were just "allegations she has made. I certainly hope she was more discreet about her obligations to Hadassah than she was about her sex life [which is] far less interesting." Zing! [Via Daily Intel] .So much for any hope he ever had of having a cool prison name, like "Stimulus Package."


text:
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We recently did our first design using Allegro version 16.5 and I am having problems highlighting parts when using the viewer of the same version.
In the past I could zoom in anywhere on the PCB, click the "I" icon then use find to locate the part by refdes and the highlighted part would jump to the middle of the display.
With the new version this does not happen. What is does now is zoom out so you can't find the part. I can open 16.3 PCBs in the 16.5 viewer and it works like I just described above where the part jumps to the center screen with no change in zoom. Has anybody else seen this behaviour?
I'm just the guy trying to debug PCBs in the engineering lab and this is one of the most important features I use and now it's broke....
I showed our PCB designer and she did not know how to make it work either.
I'm still on 16.3 so I'm not sure but this might be what you are looking for.
In reply to Mstrghettorigg:
I've just tried doing exactly as you have described and it appears to work correctly. I'm using the 16.5 physical viewer and performing the following steps:
1. Turned all subclasses off except Pkg_geom - Place bound top and bottom and Pin - Top and bottom
2. Ensured I have no other active commands and zoomed in to an arbitrarily small area anywhere on the board. (This might be the important step you are missing)
3. Selected the "I" icon (information)
4. Selected Find - Symbols only
5. Using "Find By Name" selected "Symbol (or Pin)"
6. Clicked "More" to open the "Find by Name or Property" menu.
7. Arbitrarily selected a component from the list of refdes on the left and observed it being added to the "Selected objects" list on the right.
8. Clicked "Ok" and observed my screen automatically zoom and highlight the selected component.
Let me know how you make out.
MstrghettoriggI'm still on 16.3 so I'm not sure but this might be what you are looking for.http://www.cadence.com/Community/forums/t/23167.aspx?PageIndex=1
Add the commands shown in this above mentioned link and then you can use "ctrl-f" which will bring up a pop-up bux where you can enter the reference you are looking for. It works well.
I ran into this issue a while back and started that thread. It is a very good thread if your designer has the time to read through it all. Lots of good info in it.
In reply to budnoel:
Thanks for the reply. I gave it a try and it did the same thing. I normally do this when zoomed in and it usually keeps the zoom I have or zooms in closer.
I'm going to read thru the find thread and see what I can learn from that. I also forwarded it to our designer. I can't work on this full time so it might take me awhile to figure it out...
UPDATE: I was chatting with one of our EEs and he showed me a different way to zoom to the part that works in 16.5!
Click on the "i" icon, click on the find tab, select symbol in the Design Object Find Filter, select symbol in the FindByName, type the refdes in the FindByName entry box and hit return. The show element dialog box will pop up. Click on the origin-xy number. That will center the refdes on the screen. Click on the zoom icon until the part is displayed to your desired size.
Alternately you can type "symbol refdes" on the command line and it will open up show element dialog. Then clik on the origin-xy number to center the part and zoom as needed.


text:
Which version of Windows 7 are you using is it 32 or 64bit? And I also noticed you said XP SP2 - it should be SP3 for gaming these days.
Click Here for G2Play for great deals
Oh and Don't forget some tuts on ASM and defeating DMA
Clicky Here for them
yes, i'am using dual os, but almost game installed and run on 7 (32 bit).
Yeah, talking about bottlenecking, (DABhand also mentioned before), i dont have good hint for this... but Assasin creed II 1.02 patch (a game which should be processed by more than 2 cores?)is working fine in our rig. But you have point that the number of cpu core which needed to run recent games are more-than-2-cores cpu (Link)
And actually there is one more obstacle, i hope this is the last one, is static noise coming from my GTX 460, but i think it would be nice to have take a break.. because IT'S weekend!(is it?), but every comment is very welcome.
We looking foward for further discussions. Have a nice weekend.
I was wondering about noise coming from graphics stuff too, because whenever I move the mouse and I'm in my headphones, I hear some weird static noise that mirrors my mouse movement, and pretty much just anything that happens on the screen, I hear some static that's in sync with every movement. It's very strange. It happened with my old 5200, 7300, and my 285GTX.
* Updated game trainers and cheats daily
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* Request which games get new trainers
* Priority support with any problem


text:
Skype was dying anyway
All those people who claimed skype was the best should ask why they did not pay for the premuim services earlier.
Skype was making a loss year after year, they would have died eventually or they would have been bought by Google which would have assimulated Skype into google talk (could be a good thing or a bad thing), Apple would have done they same as they prefer their brand name (facetime) over the Skype one.
Why worry, its not going to change much and I don't think the multi platform support will dissapear (apart from the linux version, which is a maybe).


text:
Navigating the Big Data Archipelago
July 1, 2013
We are awash in data, and our ability to process, analyze, and manage this data is directly correlated to our incumbent understanding of the data's rich value. Discover 10 best practices for a marketer's big data journey.
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text:
Daniel Johnston to Open for The Breeders and Neutral Milk Hotel at The Hollywood Bowl, 9/18
Daniel Johnston will make his debut at the Hollywood Bowl, opening for The Breeders and Neutral Milk Hotel on September 18 at 8 p.m.
Daniel Johnston has spent the last 20 or so years exposing his heartrending tales of unrequited love, cosmic mishaps, and existential torment to an ever-growing international cult audience, gaining considerable notoriety as an outsider and indie music genius. The bulk of his considerable acclaim snowballed from a series of homemade, lo-fi cassettes which Daniel started recording and handing out on the streets of Austin in the early 80s. Daniel has produced hundreds of songs and art pieces, compulsively expressing a frank, painful, and heart-rending account of love, life, and loss that strikes a chord in the heart of thousands who hear him. He has a remarkable following of fans, most notably the late Kurt Cobain who often wore Daniel's "Hi How Are You" T-Shirt. Daniel has produced over twenty albums, as many singles, and his music is included on numerous compilations, movie soundtracks, and television commercials. His art has been exhibited around the world including the Whitney Museum of American Art. Throughout his career, Daniel's songs and drawings have been informed to some degree by his ongoing struggle with manic depression - lending an added poignancy to his soul-searching times. The Devil and Daniel Johnston is a 2005 documentary film that chronicles Johnston's life from childhood up to the present, with an emphasis on his experiences with bipolar disorder, and how it manifested itself in demonic self-obsession. The film won the Documentary Directing Award at the 2005 Sundance Film Festival.
Neutral Milk Hotel, The Breeders and Daniel Johnston will perform on Thursday, September 18, 2014, at 8 PM at THE HOLLYWOOD BOWL, located at 2301 N Highland Avenue, Los Angeles, CA 90068. Tickets for the Hollywood Bowl 2014 summer season are available now at HollywoodBowl.com or via credit card phone order at 323.850.2000.


text:
Sallie Auld is placing earphones over some tender ears as she again helps test children's hearing in schools throughout Pasco County.
The volunteer stint with the Sertoma Speech and Hearing Foundation is one she adores, one she has been doing for four years now.
"I love it," said Ms. Auld, 72, in between testing 4-year-old students in the Head Start program at Quail Hollow Elementary. "I just love working with the children, and it makes me so happy when they can hear."
Of course, children this age sometimes need a little coaxing, but a colorful sticker often helps. And they don't always understand the instructions to "raise your hand when you hear the beep."
Not a problem, according to Ms. Auld, who has volunteered in the schools ever since her now-adult children were elementary students in Miami.
"You just watch their eyes," she said. "They may not raise their hands, but you know they hear it when their eyes light up."
>> More volunteers are needed to conduct hearing screenings at remaining schools. To help, call (727) 834-5479 or toll-free at 1-866-999-2443.


text:
ucy has moved into a house in Magnolia where her guild Fairy Tail is located. As Lucy is talking about how great her house is Natsu and Happy barge in, to Lucy's dismay. As she fails to get them to leave she shows them her Celestial spirits before then opening the gate of Canis Minor to form a new contract with the spirit, which she names Plue. After inviting her to join him to make up a team, Natsu presents her with a job to steal a book from the mansion of Duke Everlue. They travel to Shirotsume Town to meet the client who is desperate to get the book. They find the book and Lucy insists on reading it because she beliefs it contains a secret despite Everlue furiously trying to reclaim the book.Resumen IMDb.com
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|Nombre del documento
|Fairy Tail - S01E03 - Invade! The Everlue Mansion!.srt


text:
Laverne Cox was a vision at the 2014 BAFTA Los Angeles TV Tea in a Valentina Kova Fall 2014 White Long Sleeve Peplum Blouse and White Curved Hem Pencil Skirt:
Her top was paired with navy trousers for the perfect office-chic ensemble.
Her skirt was shown in navy with a red, fringe-accented top and fierce pointed-toe pumps. The curve of Laverne's skirt was brought closer to the knee for a more demure look.
Yes Laverne! I wanted a bit more in the shoe choice here, but I think it's safe to say she's been positively flawless in the style department of late.
What do you think? Hot! or Hmm…?
*Also at the party were Ashley Madekwe in Christian Dior and Niecy Nash in a $326 Clover Canyon Painted Metal Printed Zip-Front Dress. Thoughts on their choices?
Images: Getty


text:
TAMPA, Fla. -- Finally, there was some consistency out of a Tampa Bay Buccaneers quarterback.
"I'm not commenting at this time," Josh Freeman said.
Then he said the same thing again and again. I heard Freeman give the same answer at least nine times after Sunday's 13-10 loss to the Arizona Cardinals.
This is what it has come to: Freeman, who once was considered the franchise quarterback, was the first player out of the locker room. He was chased through a tunnel by a large group of media members and, after at least the 10th "I'm not commenting at this time," Freeman put in ear buds to get away from the noise.
Freeman, who was benched in favor of rookie Mike Glennon, didn't even play in the game. But he's still a huge part of the story of what quickly has become one of the NFL's most dysfunctional franchises. He previously told ESPN he wanted a trade. He didn't even get to spend the game on the sidelines with his teammates.
According to coach Greg Schiano it was a "mutual decision" to have Freeman sit in a suite with the other inactive players. That sounds to me like "We don't want this guy anywhere near the team. We're going to get rid of him one way or the other during our bye week."
Schiano made his point with his power play on Freeman. He started Glennon to prove a point. Schiano has coveted Glennon ever since he unsuccessfully tried to recruit him to Rutgers. When the move was made, Schiano said it was because Glennon gave the Bucs the best chance to win.
The irony here is that it really didn't matter who the quarterback was. The Bucs, who controlled the game most of the way, were destined to lose this game no matter what.
The problems run much deeper than the quarterback.
"It starts with me," Schiano said. "It's everyone. It's our coaching and our playing. The quarterback's part of that, but there's a bunch."
Yeah, there's a bunch of something, and it's not good. The Bucs sent a pretty strong signal that they were ready to win this year when they signed safety Dashon Goldson and traded for cornerback Darrelle Revis.
But, one month into the season, the Bucs are 0-4 and there are signs of disarray that go way beyond the rift between Freeman and Schiano.
"I know this team will stay together," Schiano said. "These first four don't count any more than the next 12. We'll take them one at a time. We've got good football players, a good team. We're just not playing very well right now."
The Bucs head into the bye week with the prospect of Glennon as the starter for the rest of the season, and it sure feels like Freeman will be traded or released.
Does it really matter that the Bucs now have a Schiano "guy" playing quarterback?
I don't think it does. This is a very flawed football team. The Bucs made some late mistakes to lose the opener to the New York Jets. They made more the following week in a similar loss to New Orleans.
These guys know how to lose the close ones. But this one was particularly painful because it started with some promise. Glennon played well (not great, but not bad) for the first 56 minutes. Led by a defense that played well all day, the Bucs held a 10-3 lead.
With 3:12 remaining, Glennon had a pass intended for Vincent Jackson intercepted by Patrick Peterson. That set up a quick Arizona touchdown to tie the game. With 56 seconds left Glennon, again throwing for Jackson, was intercepted by Peterson to seal the loss.
"Mike stepped in there like he was supposed to step in there,'' left tackle Donald Penn said. "I thought he handled it very well. He took control of the huddle, took control of the offense, and we have to help him out more. We have to make more plays, we have to finish our drive better and make it easier. We need to help this defense out. They're playing their butts off, and we have to pick it up."
First it was Freeman vs. Schiano. Next, it could be defense vs. offense. The Bucs head into their bye week with a slew of problems.
"I am concerned because we're not doing it, so we have to find a way to get the tide turned and get to playing the way we're capable of,'' Schiano said. "That all starts with me. As the head coach, I've got to make sure we're doing everything that we can within our power to perform better."
Schiano is right in saying it starts with him. If nothing else, Sunday showed it doesn't matter who is playing quarterback for the Bucs. The issues start at the top, and are running in a lot of different directions.


text:
NEW YORK (TheStreet) -- Cree Inc (CREE) shares were upgraded to "buy" from "hold" by analysts at Needham on Wednesday.
The firm set a price target of $64 on the stock.
Must Read: Warren Buffett's 10 Favorite Growth Stocks
STOCKS TO BUY: TheStreet Quant Ratings has identified a handful of stocks that can potentially TRIPLE in the next 12 months. Learn more.
Cree shares are up 2.7% to $57 in pre-market trading today.
The firm sees an worldwide interest in LED lighting growing and believes that Cree is positioned to be at the forefront of the growth.
"Based on strengthened demand for LED lighting, we believe CREE will deliver strong revenue and earnings growth in the coming quarters," Needham analysts said. "Longer term, we believe LED lighting is entering a phase of rapid adoption in multiple markets worldwide, and in our view CREE remains the best idea for investors to leverage this trend."
Separately, TheStreet Ratings team rates CREE INC as a Buy with a ratings score of B-. TheStreet Ratings Team has this to say about their recommendation:
"We rate CREE INC (CREE) a BUY. This is driven by a few notable strengths, which we believe should have a greater impact than any weaknesses, and should give investors a better performance opportunity than most stocks we cover. The company's strengths can be seen in multiple areas, such as its robust revenue growth, largely solid financial position with reasonable debt levels by most measures, impressive record of earnings per share growth, compelling growth in net income and good cash flow from operations. We feel these strengths outweigh the fact that the company has had lackluster performance in the stock itself."


text: Struggling telecom-equipment vendor Lucent Technologies last week named its president and CEO, Patricia Russo, as chairman, replacing longtime head Henry Schacht, who remains as an outside board member. Russo returned to Lucent in 2002 after a two-year stint as president and chief operating officer of Eastman Kodak. Before that, she was head of Lucent's Service Provider Network division, which is the area where Lucent has staked much of its come-back potential.


text:
Name: LimaranAge: 27Occupation: Sports Programme ManagerRockin': The Nokia Lumia 1320 and flare dress from ZaloraBest Quote So Far: "I lift weights the size of men but am still as feminine as the girl next door"
Pics: Smartphone or Camera? CameraHashtags: Important or pointless? Important! Plants or Zombies? PlantsXbox One or PS4? PS4
"If only I could record my life on Google Glass so everyone could actually see how ecstatic I am to be part of the Cover Girl Search. You should have seen me on my first photo shoot - I was a nervous wreck!
Like you, I love tech. I'm always in awe of how it's advancing. From when me and my brother took turns to play DOOM 3D and Alley Cats after completing our homework, I've never been able to live without gadgets and gear. Now, instead of floppy disks and Pentium, it's smartphones, cameras, and wearable tech. Next I want a self-driving car.
Follow me over the next six weeks (on Twitter and Instagram too!). Let me keep you entertained with my insights into a world of fashion, fitness, and lifestyle tech."
CLICK HERE and vote for Limaran to enter the S$5,000 tech bundle lucky draw.
Thanks to our sponsors...
The Stuff Singapore Cover Girl Search is powered by Nokia, Canon and Funan Digital Life Mall, and sponsored by Pioneer, Lenovo and Clarke Quay. It's supported by Zalora, Phantom Models, Power 98, Opera, WATSinside, and photography studio Vineyard Productions. All sponsors will be with us online and at offline events throughout the entire campaign - until the winner rocks the cover of our August issue. Hold on tight, it's set to be a whole heap of fun...


text:
Anna R Bergdall
Affiliation: Centers for Disease Control and Prevention
Country: USA
Detail Information
- Love and hooking up in the new millennium: communication technology and relationships among urban African American and Puerto Rican young adultsAnna R Bergdall
Oakridge Institute for Science Education, Division of Reproductive Health, U S Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
J Sex Res 49:570-82. 2012..Future research should explore emerging communication technologies and implications for psychosocial development, dating violence, and sexual behavior...
- In their own words: romantic relationships and the sexual health of young African American womenColleen Crittenden Murray
Emory University, Rollins School of Public Health, Atlanta, GA 30322, USA
Public Health Rep 128:33-42. 2013..e., strategies that simultaneously protect against unintended pregnancies and sexually transmitted diseases [STDs]) and how relationship factors influence their use of DP methods...
- A qualitative study of contraceptive understanding among young adultsMarion W Carter
Centers for Disease Control and Prevention, Atlanta, GA, USA
Contraception 86:543-50. 2012..This study describes contraceptive understanding, sources of information and consequences of contraceptive misunderstandings among urban, young adults...


text:
World Grand Prix Darts Betting
Taylor romps to 11th Grand Prix title
Record Breaking Power now 15/8 for World Championship
Published : 14/10/13 20:17 PM
Chisnall out to achieve the impossible
Taylor does not lose Grand Prix finals but will be pushed by Chizzy
Published : 13/10/13 11:04 AM
Tenacious Wade can push Taylor
Expect Chisnall to win another close semi-final
Published : 12/10/13 11:54 AM
Anderson can at least out score Taylor
Wade v Whitlock should go all the way
Published : 11/10/13 07:46 AM
Barney could just topple MVG
Pipe can push Lewis
Published : 09/10/13 21:59 PM
Taylor has too much for in form Asset
Newton can derail Flying Scotsman
Published : 09/10/13 06:25 AM
MVG can start title defence in style
In form Barney good price for comfortable win
Published : 07/10/13 20:33 PM
Wade vulnerable to Beaton at Grand Prix
Klaasen and Finnan can also pull off upsets
Published : 06/10/13 21:58 PM
Taylor looks unstoppable ahead of Grand Prix
Hamilton provides each-way value
Published : 04/10/13 22:27 PM
Dutch invasion to topple King
Mighty Mike to take the crown.
Published : 14/10/12 13:31 PM
World Grand Prix Betting
The World Grand Prix of darts is a PDC sanctioned tournament held in Dublin each October. The tournament is played over a sets format, similar to the PDC World Championship, but also has a unique 'double in, double out' feature. Players must begin their throw in each leg by hitting a double, then also finishing on a double.
World Grand Prix darts betting first began in 1998 under a different format at the Casino Rooms in Rochester Kent. It was then moved to Crosbie Cedars Hotel in Rosslare, County Wexford for the 2000 tournament before moving to the CityWest Hotel in Dublin where it has remained ever since.
World Grand Prix Information
Venue: CityWest Hotel, Dublin
Sponsor: PartyPoker.net
Founded: 1998
Number of Players: 32
Format: Sets – 'Double in, Double out'
Current Champion: Phil Taylor
Past Champions: Phil Taylor (10), James Wade (2), Alan Warriner, Colin Lloyd
World Grand Prix Darts
Phil Taylor has rewarded those backing him in World Grand Prix darts betting markets on nine previous occasions. He won the title for the first three years of its existence and has since won back-to-back titles on three spate occasions.
James Wade is the only other player to win multiple World Grand Prix titles while Shayne Burgess, John Part, Terry Jenkins and Raymond van Barneveld have all lost in two World Grand Prix betting finals. Colin Lloyd and Alan Warriner have both won the title once apiece and have also been beaten in the final of the event once each.
World Grand Prix Darts Betting News
Our World Grand Prix Darts betting news page brings you all the latest news and information from the event. Betting odds on the latest matches, form, statistics and head-to-head results can all be found in our individual match previews and summaries. Make Darts Betting News your one stop guide before placing all your darts bets.


text:
D4T or Abacavir Plus Vitamin Enhancement in HIV-Infected Patients (DAVE)
This study has been completed.
University of British Columbia
CIHR Canadian HIV Trials Network
Information provided by:
University of British Columbia
ClinicalTrials.gov Identifier:
First received: August 31, 2005
Last updated: September 24, 2008
Last verified: September 2005
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this study is to determine the best way to treat people on d4T (stavudine) with high levels of lactic acid. Switching from d4T to abacavir will be assessed. Adding riboflavin and thiamine will also be assessed.
Participants will be randomly assigned to one of four groups:
- Group 1 participants will continue to take d4T as part of their antiretroviral (ARV) regimen, and will be given the vitamin supplements
- Group 2 will continue to take d4T without vitamin supplements
- Group 3 will switch from d4T to abacavir and receive the vitamins
- Group 4 will switch from d4T to abacavir without vitamin supplements.
The study plans to involve eighty participants from Canada and Argentina for a treatment period of 16 weeks and a follow-up visit at week 24.
|Acidosis, Lactic
|Drug: d4T Drug: Abacavir Drug: Riboflavin and Thiamine (Supplementation)
|Phase 2 Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|Randomized, Open-Label Study of Continued Stavudine Versus Abacavir Substitution With or Without Riboflavin and Thiamine Supplementation in HIV-Infected Patients Who Have Elevated Venous Lactic Acid While on Stavudine-Based Therapy (DAVE)
Resource links provided by NLM:
MedlinePlus related topics: HIV/AIDS
Drug Information available for: Thiamine Riboflavin Stavudine Abacavir Abacavir sulfateU.S. FDA Resources
Further study details as provided by University of British Columbia:
Primary Outcome Measures:
- Proportion of patients per arm with random venous lactic acid (RVLA) below or equal to 2.1 mmol/L* at 16 weeks. (* Confirmed by a second determination 7-14 days later.) [ Time Frame: 16 weeks ]
Secondary Outcome Measures:
- Rate of decline of RVLA levels [ Time Frame: Unspecified ]
- Absolute level of change of RVLA levels using baseline values as a covariant [ Time Frame: Unspecified ]
- Proportion of patients improving/normalizing exercise testing mitochondrial dysfunction pattern [ Time Frame: Unspecified ]
- Time to event: time to normalize venous lactic acid [ Time Frame: Unspecified ]
- Time to event: premature therapy discontinuation, viral load rebound, and progression to a new AIDS defining illness or death [ Time Frame: Unspecified ]
- Proportion of patients with at least three consecutive HIV-1 RNA determinations equal to or below 50 copies/mL during the 16 week follow-up period on an intention to treat basis [ Time Frame: 16 weeks ]
- Change in absolute CD4 from baseline [ Time Frame: Unspecified ]
- Absolute CD4/CD8 counts [ Time Frame: Unspecified ]
- Incidence of grade III and greater adverse drug effects [ Time Frame: Unspecified ]
- Metabolic laboratory assessments (anion gap, lipid and hepatic profile, and hematology) [ Time Frame: Unspecified ]
|Estimated Enrollment:
|Study Start Date:
|August 2001
|Study Completion Date:
|August 2006
|Primary Completion Date:
|August 2006 (Final data collection date for primary outcome measure)
Intervention Details:
Drug: d4T
See Detailed Description.Drug: Abacavir
See Detailed Description.Drug: Riboflavin and Thiamine (Supplementation)
See Detailed Description.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Be HIV-positive
- Be 18 years of age or older
- Have a viral load equal to or below 50 copies/mL
- Have been on a d4T-containing multiple drug regimen (at least three agents in total) for at least six months
- Have been on a stable ARV regimen for the three months prior to enrollment
- Have a venous lactic acid measurement above 2.1 mmol/L within the three months prior to enrollment and two consecutive measurements above 2.1 but lower than 6.0 within a two-week period of screening
- Be willing to discontinue L-carnitine and/or coenzyme Q10
- Be willing and able to provide informed consent
Exclusion Criteria:
- Pregnancy or breastfeeding
- Venous lactic acid equal to or above 6.0 mmol/L
- Previous exposure to abacavir
- Virologic rebound while on a previous regimen consisting of dual or triple nucleoside reverse transcriptase inhibitors (NRTIs)
- Use of hydroxyurea within the three months prior to enrollment
- Use of metformin
- Any acute cardiopulmonary illness or infection
- New AIDS-defining illness diagnosed within four weeks of enrollment
- Riboflavin or thiamine supplementation above 20 mg/day within 30 days prior to enrollment
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00143702
Please refer to this study by its ClinicalTrials.gov identifier: NCT00143702
|Canada, British Columbia
|St. Paul's Hospital
|Vancouver, British Columbia, Canada, V6Z 1Y6
|Canada, Ontario
|Positive Care Clinic
|Toronto, Ontario, Canada
Sponsors and Collaborators
University of British Columbia
CIHR Canadian HIV Trials Network
|Principal Investigator:
|Julio Montaner, MD
|University of British Columbia
More Information
Keywords provided by University of British Columbia:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Dr. Julio Montaner, University of British Columbia
|ClinicalTrials.gov Identifier:
|NCT00143702 History of Changes
|Other Study ID Numbers:
|Study First Received:
|August 31, 2005
|Last Updated:
|September 24, 2008
Keywords provided by University of British Columbia:
Elevated Lactic Acid
Additional relevant MeSH terms:
Acidosis, Lactic
Acid-Base Imbalance
Metabolic Diseases
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Anti-HIV Agents
Vitamin B Complex
Growth Substances
Physiological Effects of Drugs
Photosensitizing Agents
Dermatologic Agents
ClinicalTrials.gov processed this record on September 21, 2017