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Golden Age to Premiere at Kraine Theater March 29
GOLDEN AGE a hilarious and thought-provoking new play by Roberto Aguirre-Sacasa (fresh from his Second Stage Theater hit The Mystery Plays) will receive its New York Premiere at The Kraine Theater on March 29.
Previews begin March 29; Opening Night April 1st at The Kraine Theater.
A Tobacco Bar Theatre Company production directed by Claire Lundberg (Off-Bway's Getting Into Heaven), GOLDEN AGE is a comic book fantasia that journeys through time and space, chronicling the life and times of freckled, red-headed, Archie-esque everyman Buddy Baxter - His rise from high school heartthrob to college misfit to struggling New York writer.
GOLDEN AGE features a cast including Cameron Cash, Michael Chernus, Sarah Elliott, Greg Felden, Christopher J. Hanke, Christopher Kromer, Tami Mansfield, and Chuck Wagner.
GOLDEN AGE also showcases the work of set designer Wilson Chin, costume design by Melissa Levin, lighting design by Matt Richards and sound design by Daniel Baker.
Roberto Aguirre-Sacasa's The Mystery Plays received the Roger L. Stevens Award from the Kennedy Center Fund for New American Plays in 2002. Subsequently, in February of 2004, The Mystery Plays was presented in England as part of the Old Vic/New Voices series before receiving its world premiere in a co-production between 2econd Stage Theatre and Yale Repertory Theatre (winning the Connecticut Critics' Award for Outstanding Play/Production). His other writing credits include The Muckle Man, Say You Love Satan (Excellence in Playwriting Award at 2003 International Fringe Festival in New York City), and Dark Matters. Currently the playwright-in-residence at 2econd Stage Theatre in New York (through a grant from the NEA and TCG), Roberto is working on commissions for Manhattan Theatre Club, the Geva Theatre, and California Shakespeare Festival. He also writes "Fantastic 4" and "Nightcrawler" for Marvel Comics.
Claire Lundberg directed Roberto Aguirre-Sacasa's SAY YOU LOVE SATAN for the 2003 New York Fringe Festival, where it was nominated for a GLAAD Media Award. Other directing credits include: Getting into Heaven (Flea Theater), Three More Sleepless Nights (Drama League Director Fest), Home (Fordham University), The Striker, Pericles, Machinal (Yale School of Drama). She was the Associate Director for Alan Bennett's Talking Heads, and assisted Stephen Daldry on New York Theater Workshop's production of Caryl Churchill's Far Away. She is a graduate of the Yale School of Drama and a recipient of a Drama League Directing Fellowship, and currently works in creative development at Tribeca Films.
The Kraine Theater, 85 E. 4th St. (Between 2nd and 3rd Avenues)
March 29 through April 22
Wednesday, Thursday, Friday @ 7.30p.m. (Saturday, April 23 at 2:30)
Tickets: Adults $15, Students $10. To purchase tickets call SmartTix: 212-868-4444
or online @ www.horseTRADE.info


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Beiber and Slipknot Mashup of 'Psychosocial Baby' [VIDEO]
I'm not the first one to bring you this video. Critter talked about it in March of 2011, saying that it's the only way for Justin Beiber to suck less, and he has a point. This is about the only way I'd willingly listen to J.B., but I won't make it a habit of coming back for more. It's a mashup of the Beibster and Slipknot in a song dubbed "Psychosocial Baby." I'm posting it again because it's just too weird to forget about.
Corey Taylor has talked about this song publicly, saying that he wouldn't mind doing music with Justin Beiber, though there aren't any plans at this point for them to enter the studio and belt out any ballads. Now the question is, which would make better music? J.B. and Slipkot, or paired with Stone Sour?
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The recent whole-genome scan for breast cancer has revealed the FGFR2 (fibroblast growth factor receptor 2) gene as a locus associated with a small, but highly significant, increase in the risk of developing breast cancer. Using fine-scale genetic mapping of the region, it has been possible to narrow the causative locus to a haplotype of eight strongly linked single nucleotide polymorphisms (SNPs) spanning a region of 7.5 kilobases (kb) in the second intron of the FGFR2 gene. Here we describe a functional analysis to define the causative SNP, and we propose a model for a disease mechanism. Using gene expression microarray data, we observed a trend of increased FGFR2 expression in the rare homozygotes. This trend was confirmed using real-time (RT) PCR, with the difference between the rare and the common homozygotes yielding a Wilcox p-value of 0.028. To elucidate which SNPs might be responsible for this difference, we examined protein–DNA interactions for the eight most strongly disease-associated SNPs in different breast cell lines. We identify two cis-regulatory SNPs that alter binding affinity for transcription factors Oct-1/Runx2 and C/EBPβ, and we demonstrate that both sites are occupied in vivo. In transient transfection experiments, the two SNPs can synergize giving rise to increased FGFR2 expression. We propose a model in which the Oct-1/Runx2 and C/EBPβ binding sites in the disease-associated allele are able to lead to an increase in FGFR2 gene expression, thereby increasing the propensity for tumour formation.
Author Summary
Recently, a number of whole-genome association studies have identified genes that predispose individuals to common diseases such as cancer. The challenge now is to understand how the identified risk loci contribute to disease, since the majority of these loci are located within introns (which are discarded after transcription) and intergenic regions, and therefore do not change the coding region of nearby genes. This manuscript describes how two single–base pair changes in intron 2 of the FGFR2 (fibroblast growth factor receptor 2) gene, "the top hit" of the breast cancer susceptibility study, exert their function. We find that the changes alter the binding of two transcription factors and cause an increase in FGFR2 gene expression, thus providing a molecular explanation for the risk phenotype. This is the first functional study, to our knowledge, of the risk loci identified for breast cancer in a whole-genome scan and demonstrates that these studies can be used as valid starting points for studying the underlying biology of cancer.
Citation: Meyer KB, Maia A-T, O'Reilly M, Teschendorff AE, Chin S-F, Caldas C, et al. (2008) Allele-Specific Up-Regulation of FGFR2 Increases Susceptibility to Breast Cancer. PLoS Biol 6(5): e108. https://doi.org/10.1371/journal.pbio.0060108
Academic Editor: Aravinda Chakravarti, Johns Hopkins Medical School, United States of America
Received: December 17, 2007; Accepted: March 20, 2008; Published: May 6, 2008
Copyright: © 2008 Meyer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: We acknowledge the support of The University of Cambridge, Cancer Research UK, Hutchison Whampoa Limited and the NIHR Cambridge Biomedical Research Centre. BAJP is the Li Ka Shing Professor of Oncology at the University of Cambridge.
Competing interests: The authors have declared that no competing interests exist.
Abbreviations: ChIP, chromatin immunoprecipitation; EMSA, electrophoretic mobility shift assay; ER, estrogen receptor; FGFR2, fibroblast growth factor receptor 2; SNP, single nucleotide polymorphism
FGFR2 (fibroblast growth factor receptor 2) plays a pivotal role both in mammary gland development and in cancer [1]. The FGFR2 gene encodes a transmembrane tyrosine kinase and can function as a mitogenic, motogenic, or angiogenic factor, depending on the cell type and/or the microenvironment. Mammary epithelial cells express FGFR2IIIb (including alternatively spliced exon 9), which binds FGF-7 and FGF-10, which are normally expressed by surrounding mesenchymal cells. Mouse models of mammary carcinogenesis have long established the FGF signalling pathway as a major contributor to tumorigenesis [2], and a mouse mammary tumour virus (MMTV) insertional mutagenesis screen for genes involved in breast cancer has identified FGFR2 and FGF10 [3]. In human breast cancer, the expression of FGFR2 has long been known to be elevated in estrogen receptor (ER)–positive tumours [4], which has been confirmed by data analysis performed with the ONCOMINE 3.0 array database [5,6]. Likewise both FGF-7 and FGF-10 have been found to be expressed in a proportion of breast cancers [7, 8]. Functional studies in cell lines have implicated FGFR2 as playing a role in tumourigenesis, with an alternative splicing in the C-terminal domain of FGFR2 giving rise to a more strongly transforming isoform [9]. However, as yet, nothing is known about the mechanism by which FGFR2 acts as a risk factor in predisposition to breast cancer.
We examined the functional implication of genetic variation in the FGFR2 haplotype associated with susceptibility to breast cancer and we demonstrate increased gene expression for the risk allele.
Two independent studies have identified FGFR2 as risk factor in breast cancer [10,11]. We have shown that in Europeans, the minor disease-predisposing allele of FGFR2 is inherited as a haplotype of eight single nucleotide polymorphisms (SNPs) covering a region of 7.5 kb within intron 2 of the gene [10] (Figure 1), in a haplotype block with no linkage disequilibrium with the coding region of the gene. Microarray gene expression analysis on the Nottingham City Hospital cohort, using both the Agilent [12] and the Illumina [13] platforms, indicated that FGFR2 is expressed at higher levels by tumours that are homozygous for the minor alleles than by those with the common alleles (Wilcox p < 0.05). Analysed tumours were all diploid for this region based on array-comparative genome hybridization data [14]. This correlation was independent of either ER expression or p53 mutation status of the cells. Quantitative TaqMan PCR analysis confirmed a significant increase in FGFR2 expression in rare homozygotes, as compared to common homozygotes (Wilcox p = 0.028) (Figure 2). We also examined expression of the FGFR2 ligands FGF-7, FGF-10, and FGF-22, which are usually produced by the surrounding stroma, in 45 normal breast samples as well as the microarray data on tumours, but we found no correlation with genotype. Furthermore, FGFR2 displays a very complex splicing pattern with the most commonly expressed variants of the N terminus of the gene either including exons 1, 2, and 3 or including exons 1 and 2, but lacking exon 3. Again, no correlation was observed between genotype and the presence or absence of exon 3. Thus, the risk genotype correlates with FGFR2 expression itself, rather than affecting its function through receptor-ligand interactions.
Genetic linkage is taken from HapMap, and the positions of the eight candidate SNPs (red lines) within intron 2 are indicated. The two SNPs for which data are presented in this study are shown in green. Red circle: original tagging SNP rs2981582.
Quantitative RT-PCR was carried out using a probe targeting the 3' UTR of FGFR2.
This correlation suggests that the functional SNPs map to a regulatory region within the gene, possibly by altering one or more transcription factor binding sites. Interactions between proteins from nuclear extracts and DNA were examined for the eight most strongly disease-associated alleles (Figure 1). Two of these candidate functional SNPs showed distinct binding patterns in electrophoretic mobility shift assays (EMSA). The common allele of rs7895676 (FGFR2–33) formed strong protein–DNA complexes with nuclear extracts from the breast carcinoma cell lines HCC1954 (Figure 3A) and PMC42 and from HeLa cells (unpublished data), whereas no binding was detected on the minor allele. Competition studies and supershift experiments identify the bound protein as C/EBPβ (Figure 3A). We note that the FGFR2–33 sequence has considerable homology to the C/EBPβ binding site from the interleukin 6 (IL-6) promoter [15] (Figure 3C). The heterogeneity of the observed protein–DNA complexes is most likely due to the presence of multiple C/EBPβ isoforms. For rs2981578 (FGFR2–13), both alleles give rise to a strong protein–DNA complex in HCC1954 cell extracts. However, a second more slowly migrating complex was only seen on the rarer genotype (Figure 3B). Interestingly, both alleles are able to compete for both bands, suggesting that the formation of the upper complex depends on the presence of the lower complex. Inspection of the FGFR2 DNA indicated the presence of a perfect octamer binding site immediately adjacent to the SNP, while the SNP itself lay within a sequence with homology to Runx binding sites (Figure 3C). Competition studies and incubation with specific antisera shows that both alleles bind Oct-1, while only the minor allele binds Oct-1 and Runx2 in HCC1954 nuclear extracts (Figure 3B), as well as in PMC42 cells (Figure S1).
EMSAs on (A) FGFR2–33 and (B) FGFR-13 minor (m) and common (c) alleles, using 5 μg (FGFR2–33) and 2 μg (FGFR2–13) of HCC1954 nuclear extracts. Competitor oligonucleotides (minor, common, and ER as negative control) and antisera are indicated above each lane.
(C) Alignment of the sequence around FGFR2–33 with binding site of C/EBPβ in the IL-6 promoter [15] and of FGFR2–13 with the Oct/Runx site in the β-casein gene [18]. The SNP is shown in red and the allele binding the transcription factor is shown.
(D) ChIP assays for FGFR2–13 and FGFR2–33. Enrichment for the minor (HCC70–/–) and the common (T47D+/+) genotype is given relative to a negative control (TRXR2, located on 22q11.2) after normalisation against rabbit IgG.
To establish whether or not these sites were occupied in vivo, we carried out chromatin immunoprecipitation (ChIP) experiments using the ER+ breast cancer cell lines HCC70 and T47D, which are homozygous for the minor and the common FGFR2 alleles, respectively. In addition, we confirmed that these cell lines were diploid for the FGFR2 locus and only expressed the epithelial-specific isoform FGFR2IIIb [16]. The ChIP analysis was carried out on homozygous cell lines, because the SNP overlapping the C/EBPβ site lies in a repetitive region for which the different alleles could not be distinguished reliably by TaqMan PCR. A representative experiment is shown in Figure 3D. After Runx2-precipitation, the FGFR2–13 site is enriched 2-fold for the minor versus the common allele, confirming the EMSA results. Western blotting indicated that Runx2 is more abundant in T47D cells, thus confirming that differential ChIP in the two cell lines is due to the presence of the SNP. Oct-1 precipitation did not yield enrichment of FGFR2–13 for either allele. The Oct-1 epitope may either be sequestered within a higher-order complex or the antisera used do not work efficiently in a ChIP assay. On the FGFR2–33 site, we observed a 1.7-fold enrichment of C/EBPβ binding on the common allele. In addition, we observe that C/EBPβ can also bind to the minor allele, although less efficiently. Both cell lines contain comparable amounts of C/EBPβ as judged by Western blotting (unpublished data). In conclusion, both the C/EBPβ and the Runx2 binding sites are occupied in vivo.
To test whether differential protein binding could alter the ability of the susceptibility alleles to activate transcription, we multimerised oligonucleotides overlapping both the Oct-1/Runx2 and the C/EBPβ binding sites, cloned these in both orientations upstream of the luciferase reporter gene in pGL3Enh (Figure 4A), and assayed them in three breast cancer cell lines (PMC42, HCC70, and T47D). Transfections were carried out in triplicate and repeated at least twice for each cell line. A representative transfection into HCC70 cells is shown in Figure 4B (see Figure S2 for PMC42 and T47D). In all three cell lines tested, the minor allele at the Oct-1/Runx2 site stimulated transcription 2- to 5-fold over the common allele, independent of orientation, with the average being just above a 3-fold increase (p < 0.01). In contrast, the minor and common alleles of the multimerised C/EBPβ binding site did not show a consistent pattern of activation relative to each other. It varied with the cell lines and the orientation in which constructs were tested. Nevertheless, relative to the parental vector, the common allele always showed transcriptional activation. Compared to the common allele, the minor allele was either not significantly different or gave rise to a smaller degree of activation. However, in the latter case, the rare allele still activated transcription significantly above the enhancer-only construct (p < 0.01). Presumably this reflects the fact that the minor allele of FGFR2–33 still binds C/EBPβ above background levels in vivo (Figure 3D). By comparing the two different sites, we found that for Oct-1/Runx2 the minor allele was more active, while for C/EBPβ, the common site yielded higher levels of transcription in the majority of experiments. Hence their effects were opposing. We therefore assayed a synthetic construct consisting of single sites for C/EBPβ, Oct-1, and Runx2. In this arrangement, the effect of Oct-1/Runx2 clearly predominates, with the minor allele expressed at higher levels, reflecting the situation at the endogenous locus.
(A) Diagram of the concatemerised binding sites cloned into pGL3Enh.
(B) Luciferase assays in HCC70 cells. Results are given as fold increase over pEnh activity. CMV-β-gal served as transfection control. The binding sites are indicated beneath each data point, with [Oct/Runx] and [C-EBPβ] being trimerized, while [C/O/R] contained only a single binding site for C/EBPβ, Oct-1, and Runx2. The asterisk denotes p-values <0.05 in a Student's t-test comparing the common versus the minor allele of each site.
The data presented here lead us to conclude that the Oct-1/Runx2 binding site is the dominant determinant of differential expression between the common and minor haplotypes of FGFR2. Although Runx2 is a master regulator of osteoclast-specific transcription, Runx2 also plays an important role in mouse mammary gland–specific gene expression [17], where Runx2 activity is dependent on Oct-1 [18]. It is intriguing to note that in bone cells, overexpression of constitutively active FGFR2 leads to increased levels of Runx2 mRNA [19]. FGFR2 in turn is responsive to Runx2 in osteoclasts via the OSE2 (osteoclast specific element 2) in its promoter [20]. The description here of a Runx2 site in the FGFR2 gene that is occupied in breast cancer cells, suggests that in the presence of the minor genotype, a similar positive feedback loop could also be established in breast cells. The role of the C/EBPβ binding site on FGFR2 expression has been harder to define. The common allele binds C/EBPβ more tightly and activates transcription more strongly in most cases. Yet in a composite construct the activity of the Oct-1/Runx2 site dominates. This may be because C/EBPβ can directly bind to and synergize with Runx2 [21]. Thus, on the minor genotype, Oct-1 and Runx2 are present and able to synergize with the C/EBPβ bound (as suggested from the ChIP experiments), giving rise to higher levels of transcriptional activation. This is supported by the finding that a single copy of the C/EBPβ/Oct-1/Runx2 site gives rise to higher levels of activation than a concatemerized Oct-1/Runx2 site with six potential interaction sites (Figure 4A). A potential role for C/EBPβ in tumour etiology is supported by the observation that C/EBPβ is highly overexpressed in malignant human breast cells [22]. In conclusion, our evidence supports Oct-1/Runx2 as the probable primary determinant of activity, with C/EBPβ contributing to the risk haplotype.
The increased risk in breast cancer conferred by the FGFR2 allele is predominant for ER+ breast tumours, while there is no significant increase in risk for ER– tumours. Genome-wide analysis of ER binding sites has revealed three potential ER binding sites within the FGFR2 gene [23], and ER and Oct-1/Runx2 may cooperate to increase gene expression. This is consistent with findings that Oct and ER sites often cluster [23]. The risk conferred by the disease-associated genotype may also depend on the signalling potential of FGFR2 in ER+ cells. FGF-7 is over-expressed only in breast tumours that are ER+ [8]. Elevated levels of FGFR2 may then contribute to the establishment of an autocrine signalling loop, reducing the cell's propensity to undergo apoptosis [24]. Alternatively, paracrine signalling by mesenchymally or luminally derived FGF-7 or -10 on cells overexpressing FGFR2 may also drive cell proliferation.
To our knowledge, this is the first functional study on the risk loci recently identified for breast cancer. Our study demonstrates that SNPs identified by whole-genome scans can be used a valid starting points for studying the underlying biology of cancer. SNPs identified in other whole-genome scans for the genetic basis of complex diseases also primarily map in intronic or intergenic regions. Our observation that an identified SNP regulates the expression of the risk allele is therefore likely to be a common theme. Breast cancer is one of the most common cancers in the developed world. The FGFR2 minor allele carries only a small increase in risk and acts as part of a spectrum of risk factors. However, it has a high minor allele frequency (0.4), and FGFR2 is therefore likely to contribute to the incidence of breast cancer in many individuals.
Materials and Methods
DNA from the 170 tumour samples was genotyped using a fluorescent 5′ exonuclease assay (TaqMan) and the ABI PRISM 7900 Sequence Detection Sequence (PE Biosystems) in 384-well format. Duplicate samples were included to assess concordance and quality of genotyping. The genotyping assay was designed for rs2981582, which tags the whole haplotype block associated with the disease [10].
Analysis of FGFR2 gene expression.
Analysis was performed on total RNA from breast tumour cases. cDNA was prepared with the TaqMan Reverse Transcription Reagents kit (Applied Biosystems) using random hexamers, according to the manufacturer's instructions. Expression levels were determined using a TaqMan Gene Expression Assay (Hs00240796_m1, Applied Biosystems) and normalized to four different housekeeping genes.
Statistical analysis.
To assess whether there were significant statistical differences between the expression levels across the genotype groups we used a Wilcoxon test, fitted using the R statistical framework. Elsewhere, Student's t-tests were carried out using Microsoft Excel.
Cell lines and cell culture.
Breast cancer cell lines HCC1954, HCC70, T47D, and PMC42 were cultured in RPMI supplemented with 10% foetal calf serum and penicillin/streptomycin under standard conditions. These cell lines have been characterised extensively, and karyotypes are available at the Cancer Genomics Program of the University of Cambridge (http://www.path.cam.ac.uk/~pawefish).
Small-scale nuclear extracts and bandshifts were carried out as previously described [25], except that Complete Protease Inhibitors (Roche) were used. In supershift experiments, polyclonal antisera against Oct-1 (sc-232x), Runx2 (sc-10758x), and C/EBPβ (sc-150x) were obtained from Santa Cruz Biotechnology, Inc and up to 8 μl were added per reaction, unless otherwise stated. Oligonucleotides (Table S1) were annealed to complementary strands, and the resulting BamHI overhangs filled in with Klenow enzyme, using radiolabelled [α32P]dCTP (GE Healthcare, UK).
Primers were designed using Primer Express (Applied Biosystems) and Lasergene (DNA Star) to amplify regions of up to 100 bp comprising the SNPs of interest, plus one negative control (region of the genome not suspected to bind any of the transcription factors of interest) (Table S1). PCR amplification was carried out with Power SYBR Green Mastermix (Applied Biosystems), using 2 μl of precipitated and purified DNA as described [23]. The antisera were as in the EMSAs, except for C/EBPβ, which was a polyclonal serum from Abcam, UK.
Plasmid construction and luciferase assays.
The pGL3-Enhancer vector (Promega) was linearized with BglII and re-circularised in the presence of annealed oligonucleotides (Table S1). All constructs were verified by sequencing. DNA was prepared using Qiagen kits and transfected into tumour cell lines cultured in 24-well plates. Per well, 500 ng of reporter and 100 ng CMV-β-galactosidase plasmid were tranfected using 2 μl of Fugene 6 (Roche), harvested 36–48 h later and extracts prepared using 100 μl Promega lysis buffer. Luciferase and β-galactosidase activity in 25 μl was measured using Promega reagents. Results are given as ratios of luciferase over β-galactosidase activity.
Supporting Information
Figure S1. EMSA on the Common and Minor Allele of FGFR2–13 using PMC42 Nuclear Extracts
5 μg of nuclear extract and 8 μl of α-Oct-1 (ab15112), α-Runx2 (ab11906), and α-C/EBPβ (ab32358) from Abcam, UK, were included as shown above the lanes. ns, non-specific binding.
Figure S2. Transcriptional Activation by the Minor and Common Alleles of Oct-1/Runx2 and C/EBPβ binding sites of FGFR2
(A) Diagram of the concatemerised binding sites cloned into pEnh. These constructs were assayed in the cell lines.
(B) PMC42 and (C) T47D cells. Results are given as fold increase over pEnh activity. CMV-β-galactosidase served as transfection control. The binding sites are indicated beneath each data point, with [Oct/Runx] and [C-EBP] being trimerized, while [C/O/R] contained only a single binding site for C/EBPβ, Oct-1, and Runx2.
Table S1. Oligonucleotides Used in This Study.
Sequences in brackets show the two alleles (common/minor) of SNPs.
We wish to thank D. Easton, A. Dunning, and P. Pharoah for helpful discussion throughout the project and J. Carroll and K. Green for help and advice with ChIP assays.
Author Contributions
KBM, A-TM, BAJP conceived and designed the experiments. KBM, A-TM, MO performed the experiments. AET analyzed the data. S-FC, CC contributed reagents/materials/analysis tools. KBM, A-TM wrote the paper.
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- 20. Guenou H, Kaabeche K, Mee SL, Marie PJ (2005) A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome. Hum Mol Genet 14: 1429–39.H. GuenouK. KaabecheSL MeePJ Marie2005A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome.Hum Mol Genet14142939
- 21. Gutierrez S, Javed A, Tennant DK, van Rees M, Montecino M, et al. (2002) CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression. J Biol Chem 277: 1316–23.S. GutierrezA. JavedDK TennantM. van ReesM. Montecino2002CCAAT/enhancer-binding proteins (C/EBP) beta and delta activate osteocalcin gene transcription and synergize with Runx2 at the C/EBP element to regulate bone-specific expression.J Biol Chem277131623
- 22. Grigoriadis A, Mackay A, Reis-Filho JS, Steele D, Iseli C, et al. (2006) Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data. Breast Cancer Res 8: R56.A. GrigoriadisA. MackayJS Reis-FilhoD. SteeleC. Iseli2006Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data.Breast Cancer Res8R56
- 23. Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, et al. (2006) Genome-wide analysis of estrogen receptor binding sites. Nat Genet 38: 1289–97.JS CarrollCA MeyerJ. SongW. LiTR Geistlinger2006Genome-wide analysis of estrogen receptor binding sites.Nat Genet38128997
- 24. Hishikawa Y, Tamaru N, Ejima K, Hayashi T, Koji T (2004) Expression of keratinocyte growth factor and its receptor in human breast cancer: its inhibitory role in the induction of apoptosis possibly through the overexpression of Bcl-2. Arch Histol Cytol 67: 455–64.Y. HishikawaN. TamaruK. EjimaT. HayashiT. Koji2004Expression of keratinocyte growth factor and its receptor in human breast cancer: its inhibitory role in the induction of apoptosis possibly through the overexpression of Bcl-2.Arch Histol Cytol6745564
- 25. Meyer KB, Ireland J (1994) Activation of the immunoglobulin kappa 3' enhancer in pre-B cells correlates with the suppression of a nuclear factor binding to a sequence flanking the active core. Nucleic Acids Res 22: 1576–82.KB MeyerJ. Ireland1994Activation of the immunoglobulin kappa 3' enhancer in pre-B cells correlates with the suppression of a nuclear factor binding to a sequence flanking the active core.Nucleic Acids Res22157682


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Buffalo Sabres enforcer Patrick Kaleta is no stranger to suspensions.
On Monday, the veteran forward was suspended 10 games for an illegal hit to the head on Columbus Blue Jackets defenseman Jack Johnson from an October 10 game in Buffalo.
"Although Johnson is eligible to be checked, Kaleta takes an improper angle, misses Johnson's body and does not make a full body check. Instead, he hits Johnson directly on his chin with his left shoulder," said Brendan Shanahan of the NHL's Department of Player Safety.
It's the fourth suspension of Kaleta's career, and it wasn't surprising to see him receive more than five games because his hearing with the league was an in-person one (phone hearings result in five games or less).
This is one play that must be taken out of the game for player safety, and it's encouraging to see the NHL hand out a major punishment to Kaleta, especially since his first three suspensions didn't result in him learning a lesson.
Check out the full explanation of the suspension from the NHL in the video below.
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Police confirm body found is Taneesha Brown, missing Markham woman
MARKHAM Ont. – York Regional Police confirmed to Global News Saturday the body discovered during their search for a missing Markham woman is in fact Taneesha Brown.
Search and Rescue officers found the body in a pond in the area of Edward Jeffries Road and Highway 48 during a ground search.
York Regional Police told Global News there weren't any signs of trauma on her body and they believe she ended up in the pond because of her own actions. They are now assisting the coroner in the investigation.
Police initially did not confirm the victim's identity, but said the victim's clothes matched the description of those Brown was last seen wearing.
Brown, 25, was last seen Jan. 12 when she left a relative's home at 10:45 p.m. in the area of McCowan Road and Castlemore Avenue in Markham.
York police said she told family members she was going outside for fresh air and never returned.
Brown was later spotted speaking to a man on surveillance video a short time later near Bur Oak Secondary School but police said the interaction didn't turn up any clues.
READ MORE: Police identify man in video speaking with missing Markham woman
Anyone with information on Brown's case is asked to contact the York Regional Police #5 District Criminal Investigations Bureau at 1-866-876-5423, ext.7541 or Crime Stoppers at 1-800-222-tips.
© 2016 Shaw Media


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- AHA News Home »
- All articles »
- Online access to medical records may increase use of services
Online access to medical records may increase use of services
AHA News Now
Nov 21, 2012
Patients who have online access to their medical records and clinicians use more clinical services than patients who do not, according to a study at Kaiser Permanente Colorado reported in today's Journal of the American Medical Association. "In the year following activation, members with such access had increased rates of office visits, telephone encounters, and acute care services compared with a matched cohort of members without online access," researchers at the integrated health care delivery system found. "…If these findings are evident in other systems, health care delivery planners and administrators will need to consider how to allocate resources to deal with increased use of clinical services."
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Tom Lane wrote: > "Jim C. Nasby" <jim(at)nasby(dot)net> writes: > > I believe there's something similar for OS X as well. The question is: > > would it be better to do that, or to just delay calling fsync until the > > OS has had a chance to write things out. > > A delay is not going to help unless you can suppress additional writes > to the file, which I don't think you can unless there's very little > going on in the database --- dirty buffers have to get written to make > room for other pages, checkpoint in progress or no. I am afraid a delay between write and fsync is the only portable option we have right now --- there is hope that since the check point write, we will not have a huge number of dirty buffers at the start of the checkpoint that need to be written out. -- Bruce Momjian bruce(at)momjian(dot)us EnterpriseDB http://www.enterprisedb.com + If your life is a hard drive, Christ can be your backup. +
Next: From: Joshua D. Drake Date: 2006-12-30 02:30:21 Subject: Re: psql possible TODO Previous: From: Bruce Momjian Date: 2006-12-30 01:59:34 Subject: Re: psql possible TODO
Next: From: Jim C. Nasby Date: 2006-12-30 04:08:04 Subject: Re: Load distributed checkpoint Previous: From: Stefan Kaltenbrunner Date: 2006-12-29 23:08:56 Subject: Re: [HACKERS] Recent SIGSEGV failures in buildfarm HEAD


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Wednesday, February 04, 2009
4 comments:
Lol! Could it be Yuri Antonov's guitar:)?ReplyDelete
I love these pictures! Thanks for sharing them!ReplyDelete
Why on earth would anyone leave a poor dog chained to something in the middle of the road anywhere?ReplyDelete
The poor dog deserves much better than that!!!
People have to leave their dogs outside to enter a store.ReplyDelete
The dog indeed looks sad in that messy snow, but most probably he or she didn't have to wait too long.
Subscribe to: Post Comments (Atom)


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I thought that there was a thread for questions for MYOM. I can't find it anywhere. I was wondering if there was a link where I could find out the shipping to my zip without having to give all my info or creating an account. If its one thing that I absolutely hate is not being able to get a shipping quote without giving them all my info.
Hi, is this what you need. This will lead you to his website.
Thanks, thats not what I am looking for. If I remember correctly there was a thread for MYOM here on CC.
I remember there was a specific forum for MYOM, but when they redid the web site, it disappeared. I don't remember the username - if someone remembered that, you could send a PM. Perhaps send a PM to Jackie and ask if she knows the contact name on CC......


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For Sure! Uffda Tees T-shirt Design
National Security Adviser, General Jones, Comments on Christmas Day Bomber (video)». Ole and Sven die in a snowmobiling accident, drunker than skunks, and go to Hell.
Ole, Sven, and The Minnesota Vikings.
06.01.2009 · Sven and Ole are walking down a street in Madison, Wisconsin, when and they see a sign. First Christmas Bird Count and a Lifer! My Christmas Prayer; Grouse in the Woods
Sven- Ole Thorsen - Who or What is.
27.09.2007 · section and Sven says to Ole, "Dat's dem." The owner comes over and asks if he can. Christmas Recipes. An error has occurred; the feed is probably down. Try again later.
Panty Jokes
Sven and Ole worked together and were both laid off, so off they went to the unemployment. joke, my brother used to hang a pair of panty hose over his fireplace before Christmas.
Hasty Brook: Sven and Ole
Born in Denmark, Sven- Ole Thorsen has a remarkable sporting background as a champion. A Little Tailor's Christmas Story (1994)
Sven and Ole are sitting in the boat.
Christmas Ornaments; Cinco de Mayo; Earth Day; Halloween; Home Accessories Ice Scrapers. Ole and Sven, working as a search and rescue team, have recovered 826 bodies so far and.
Christmas ole and lena jokes - Add-A-Cart.
14.06.2008 · Swen and Ole sing a special song dedicated tuu der goot. 5:56 Add to Sven & Oly Christmas (opening) by fuscia13 23 views 0:37 Add to Ole and Sven by olddocinsf 112 views
Shortarmguy: Ole and Sven in Hell
17.11.2009 · Ole and Sven had really 'packed on the pounds' by overeating during Christmas and the New Year's Holidays, so their doctor put them on the same
Swen and Ole - YouTube
Anudder Sven. Ole Story. This is a discussion on Anudder Sven. Ole Story within the. A Christmas Story
Ole and Sven: North Dakota heroes - MacNN.
Sven Amundsen ( Sven)'s profile on Myspace, the leading social entertainment destination. In Bed By 9. Merry Christmas & a Happy New Year!
Sven and Ole Joke | Promotional Products.
Born in Denmark, Sven- Ole Thorsen has a remarkable sporting background as a champion. A Little Tailor's Christmas Story (short) Schultz
Sven and Ole - YouTube
Sven- Ole Thorsen lives in Santa Monica in California and. A Little Tailor's Christmas Story: Schultz: The Dangerous: Sven: On Deadly Ground: Otto (as Swen- Ole Thorsen)
SVEN AND OLE « More Funny Jokes
04.11.2010 · Sven is passing by Ole's hay shed one day when through a gap in the door, he sees Ole doing. A Christmas Flash Mob AWESOME! You're Number One!!! Thanks Jacob..... One tough.
The Official Sven and Ole Home Page
Ole, Lena, Sven and others still speak with the marring accent and fractured English. Ole and Lena Christmas Jokes
Ole and Lena - Ask Jeeves Encyclopedia
Uncle asked for a pair of loafers for Christmas. So we sent Sven & Ollie! --Submitted by: Dat couple in Maine! (06-09-01) One Sunday after church Sven meets Ole in the parking.
sven and ole christmas
For Sure! Uffda Tees T-shirt Design


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A Whole Different Animal
June 8, 2010
The Frontier brand needed to be built from the ground up; increasing brand awareness while fending off current and unforeseen competition that threatened to erode market share and growth. The brand's campaign strategy allowed it to create an unparalleled emotional bond in the cold, uncaring airline industry.
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1byOne Foldable Keyboard
Based on 0 ReviewsThe 1byOne Foldable Keyboard, found online at 1byOne.com, is a new foldable keyboard which has been designed to be as portable and yet still useful as possible. How Does It Work? According
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Based on 3 ReviewsAMPY, found online at GetAmpy.com, is a new mobile battery charger that captures energy from your motion and gives you the ability to charge your mobile devices while on the go. How Does It
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Using a spouse agreement contract in your personal financesWritten by Sam
I've just made a Spouse Agreement Contract available in PDF format to the newsletter subscribers. I'll be sending an email out to existing subscribers with a link. If you haven't subscribed to the newsletter yet, you can get the document by doing so.
The short video below describes how the contract works and why it's important. It may seem a little cheesy, but signing the document and having your spouse sign will really increase your commitment to the program.
Posted in 12 Weeks to Fiscal Fitness, Resources | No Comments »


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Funding cuts or state mandates have hit physical education departments hard in recent years, shrinking schedules and forcing some students out of the gym and into remedial reading or math classes.
But middle school students in Hillsborough County will likely see more physical education this fall — and some sports their parents may have never tried — thanks to a key schedule change and creative leadership from schools like Turkey Creek Middle.
This fall, the district will shift from six daily periods to seven at the middle school level, in part to conserve funds in meeting the state class-size amendment. The extra period will allow many students to take more physical education classes, said district supervisor Steve Vanoer.
"Next year, we'll be rolling out educational gymnastics," he said, describing the district's approach. "We'll have tennis, badminton, orienteering, outdoor ed — that's a whole different group of kids, and that's physical activity. We're hoping if we offer enough activity, we'll hook them on one they have a passion for."
Turkey Creek has been at the forefront of a new district effort to teach lifetime sports, along with more traditional team sports. In the process, the school has earned national STARS recognition from the National Association for Sport and Physical Education.
No other Florida middle school holds the STARS designation, which is based on standards from NASPE and the federal Centers for Disease Control and Prevention. Turkey Creek earned the honor in 2004, 2007 and again last month.
Officials from NASPE called the school "one of the elite physical education programs in the country."
On a recent morning, the Turkey Creek's physical education department chairwoman Tecca Kilmer led special-needs students in a high energy session of tae bo, an aerobic exercise that combines elements of tae kwon do with boxing moves.
The students — some of them autistic or with Down syndrome — greeted her with giggles and shouts, but quickly focused on the activity once the music started. Soon, many were puffing from the exertion.
"A lot of them are not very active," said Barbara Brannon, a classroom aide who works with several of the students. "Once they get motivated in this class, they get more exercise than they normally would."
Outside, general physical eduction classes finished their warm-up laps around the track and prepared for a session of Ultimate Frisbee.
"Pretty much all classes do cardio work, running before we get started," said teacher Ira Shaw. "Classroom teachers do bell work, we do cardio."
Promoting physical fitness has been a goal in Hillsborough, as in the rest of the country. Childhood obesity has more than tripled since 1980, according to the National Center for Chronic Disease Prevention and Health Promotion.
But officials here have worked equally hard to teach students healthy habits and instill a love of physical activity, said Kilmer.
"There's a misconception that PE is recess," she said. "We're really teaching kids how to live."
That includes teaching them how to check their pulse and aim for fitness zones within their age group, she said. The five-teacher department has also gone out of its way to develop new programs.
The school's archery club drew 180 applicants and placed 11th at a state tournament. Monthly fitness nights attract dozens of families. Students pull catfish out of a pond dug by the agriculture department, with gear purchased through a grant. And once a year, the school abandons regular classes for Olympics Day.
"They give us a lot of support," Shaw said. "The things we ask to take out of the schedule, that's not common. They act like what we do is important."
Turkey Creek's principal Dennis Mayo said the school believes in its mandate to help students build solid, lifelong fitness habits and fight health threats like obesity.
"That's a scary thought, knowing our kids might not live as long as we will," he said.
Students said it's not all fun and games, but they appreciated their school's enthusiasm for fitness.
"I like it, but it can be a pain when I'm tired," said Ashley Piechowiak, 13.
Victoria Salina, 13, said she likes trying new sports. Four-way volleyball, a rowdy version of the traditional game, is her favorite.
"Chaos?" she said grinning. "Yeah, it is."
Tom Marshall can be reached at firstname.lastname@example.com or (813) 226-3400.


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Project 7 of 21
The concept of CoffeeTime works upon the fact of coffee drives everyone to commence a day by means of the sense of smell and taste.
CoffeeTime wakes up the user by the important elements of the coffee.
The CoffeeTime borrows its shape from an hour glass to have that subtle element of...
show more »


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ATO raises money for Ronald McDonald House
April 17, 2012 • 2,747 views
Filed under Entertainment
Hang on for a minute...we're trying to find some more stories you might like.
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Web Editor's Note: To see more photos of the fundraiser, click here!
Alpha Tau Omega (ATO), a fraternity at WTAMU, hosted a double elimination co-ed softball tournament April 13-14 at the Buffalo Sports Park to raise money for the Ronald McDonald House in Amarillo.
"We have worked with the Ronald McDonald House for many years," Miguel Sosa, ATO president, said. "They have an amazing staff and, for those of us who have had the privilege of meeting the families and children who have been helped by the Ronald McDonald House, they are very appreciative and thankful for what we do."
He said ATO wants to do everything possible to help these families and children.
"Whether it is donating time or raising funds, getting to see the smile on their face is truly a heartwarming experience, and is one of the greatest feelings in the world," Sosa said.Each team had a maximum of 15 players, and there was a required minimum of five girls per team. A total of 14 teams registered for the event, and each group had to pay $150 to participate.
"What wonderful young men to be so concerned with helping other people in the community," Jan Reid, Ronald McDonald House executive director, said. "We're crazy about ATO."
Reid said ATO has helped them with a lot of projects throughout the years and that their help is very much appreciated. She is impressed by the work they put into the tournament and called the event monumental.
A family member from the Ronald McDonald House, Tony Barbour's son, started the tournament on Friday by throwing the first pitch.
Victory and 2 Legit faced off in the championship game, and 2 Legit came out on top with a final score of 13 to 6.
"We thought the event was very good for us to do because it was benefiting the Ronald McDonald House," Lacey Trinidad, 2 Legit team member, said.
2 Legit is a team from Amarillo that heard about the event and decided to get involved.
Ernesto Barrientez and Preslie Wiode were chosen as the MVP's of the tournament.
Sosa estimated that the fraternity raised between $3,000 to $4,000 for the Ronald McDonald House. ATO plans to turn the softball tournament into an annual event.


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Inside scoop on Cannes winners
Who had to hotfoot it from a barge to collect their prize, and what were the upsets of this year's festival? BBC Culture reports from Cannes.
"He actually got the call when he was on his barge with his wife today, and hot-footed it down from Holland to collect this prize." Entertainment reporter Emma Jones reveals that one of the biggest shocks of the Cannes prize ceremony was felt by Timothy Spall, who won the best actor prize for his portrayal of the painter JMW Turner in Mike Leigh's Mr Turner.
"[He] has been the frontrunner for best actor ever since this competition started with his amazing performance in Mr Turner, so it's no surprise to anybody, apart from probably Timothy Spall himself."
Mr Turner was touted as a top contender for the Palme d'Or, but it lost out to Winter Sleep by Turkish director Nuri Bilge Ceylan, who dedicated the prize "to the young people of Turkey, those who lost their lives during the last year".
While it was the bookie's favourite, some were sceptical that the three-and-a-quarter-hour drama could claim the top award. It's the second year in a row that the longest film in contention has won, following Blue is the Warmest Colour's victory in 2013.
Jones gives her take on Ceylan's win, and reveals the reaction after Julianne Moore was named best actress for her role in David Cronenberg's Hollywood satire Map to the Stars. Moore plays a self-obsessed actress suffering a breakdown, and the film has attracted attention for her sex scene with Robert Pattinson in the back of a car.
BBC Culture's report explores the festival's other surprises, including a prize shared by the 83-year-old Jean-Luc Godard and the 25-year-old Xavier Dolan, and the snubbing of favourite Two Days, One Night. The latest from the Dardenne brothers was hotly tipped for both the Palme d'Or and best actress (for Marion Cotillard), yet failed to pick up a prize. "We haven't seen perhaps the more arthouse doyennes of Cannes rewarded," says Jones.
If you would like to comment on this story or anything else you have seen on BBC Culture, head over to our Facebook page or message us on Twitter.


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A SEATING plan for the Scottish League Cup final has been agreed following discussions with Aberdeen and Inverness Caledonian Thistle.
Supporters making the long journey from the Highlands will be housed in the lower tier of the Lisbon Lions stand - the upper tier will be unused - and the near corner of the Main Stand.
Aberdeen will be allocated the rest of the stadium, and both parties declared themselves satisfied with the final arrangements, after Inverness had originally protested when details first entered the public domain.The Inverness chairman Kenny Cameron said: "We are very happy with the allocation agreed, which provides exactly what our fan base was looking for, and thank both the SPFL and Aberdeen for accommodating our wishes."
Loading article content
The chief executive of the SPFL, Neil Doncaster, added: "We believe the agreement reached represents the best possible and fairest result for fans of both clubs and will also help us create a spectacular final for those watching on television."


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All About Vaani Kapoor
Aditya Chopra's highly awaited directorial 'Befikre' released its title track 'Ude Dil Befikre' a few days ago. As per the director, the song is inherently a 'dare song', and it had the lead pair Ranveer Singh and Vaani Kapoor throwing bizarre challenges to each other. The video of the son ... read more
New-age actors don't shy away from locking lips on-screen, and the exuberant actor Ranveer Singh has kissed in almost all his films. He kissed his ex-girlfriend Anushka Sharma, his current lover Deepika Padukone, and has broken all records with Vaani Kapoor in their upcoming film 'Befikre'. ... read more
Vaani Kapoor and Ranveer Singh's latest release 'Befikre', directed by Aditya Chopra earned 21.96 crore in two days. On the first day, the film has minted Rs 10.36 crore while on ... read more
Ranveer Singh launched the wedding song 'Khulke Dulke' from his upcoming film 'Befiker', along with co-star Vaani Kapoor at an event in Delhi. The actor also took the opportunity to reveal his wedding plans, during the song launch on Wednesday (Nov 23). Ranveer said that he wants his weddi ... read more
Vaani Kapoor, the leading lady of YRF's 'Befikre' is rumoured to have lip and chin job done but the pretty actress clarified that she is just one film old and she can't afford surgery. Three years ago, Vaani debuted with YRF's 'Shuddh Desi Romance' and after such a long gap when Vaani again made ... read more
Ranveer Singh and Vaani Kapoor's latest flick, 'Befikre' showed a good response on the opening day. The film fared well on day one. YRF's 'Befikre' registered an opening day occupancy of 45%. ... read more
'Befikre' actors Ranveer Singh and Vaani Kapoor visited the sets of reality show 'Bigg Boss 10' to promote their upcoming film. The duo enlivened the atmosphere inside the house by involving the contestants in some exciting 'dare' games. They start off with a simple challenge and ask Lopam ... read more
Ranveer Singh is a friendly person and goes along well with everyone, but there is a strong buzz that the 'Bajirao Mastani' actor and Sushant Singh Rajput are not on talking terms. According to reports, the reason for this is Aditya Chopra's upcoming film 'Befikre'. Apprantly, director Adi ... read more
Ranveer Singh and Vaani Kapoor starrer 'Befikre', which opened on a great note and showed growth at the box-office during the first weekend, witnessed a dip in its collection through the weekdays. At the end of the films first week run on Thursday (Dec. 15), its total collection was pegged a litt ... read more
Ranveer Singh and Vaani Kapoor starrer 'Befikre', backed by big banner Yash Raj Films, opened to a good start and maintained a steady growth through the weekend. In three days, the Aditya Chopra directorial has grossed Rs 35.21 crores (approx.). 'Befikre' released across 2100 screens and c ... read more


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if you like you add to arc-team? we would like your help!
Sure that would be cool, thanks
I hate to ask this but how to i download this kernel? or do i have to build it myself?
Can this kernel be used on htc sensation pyramid?I want to use something that have OTG support based on 3.4 kernel,or should I say I would like to use it with slimkat rom.Thanks
You can't use this kernel with the sensation
1. Because this kernel was built for the amaze
2. It currently is a sense kernel and not aosp.
You can use only the kernels from the senny forums or your phone won't boot.
Sent from my HTC One using Tapatalk
XDA Developers was founded by developers, for developers. It is now a valuable resource for people who want to make the most of their mobile devices, from customizing the look and feel to adding new functionality.
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Patient Testimonials
"I appreciate all that you did for me."
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"Your talent, concern, kindness, patience and understanding helped me through this trying time. You are all appreciated more than you'll ever know."
"I just had to take a moment to offer my deep appreciation and thanks to you all. Your kindness, professionalism and good humor means so much in tense situations..."
"You and your staff made a most unpleasant experience extremely bearable. Your professionalism, courtesy and personal caring made me feel confident."
"Thank you for being so caring and compassionate. You are a blessing to all of your patients."
"Your professionalism and tender care was very much appreciated"
"I was very frightened, but you and your staff made it so pleasant. I would encourage all new patients to rest easy… they are in excellent and skilled hands."
"The past few months had some very scary moments, but your quiet confidence gave me courage. Thank you for making this process as painless as it was and, mostly, for the great results!"
"I compliment you on the excellent staff personnel with whom I became acquainted."
"Thank you for all the care and support you gave me… I appreciate the kindness that was shown to me by your staff…they were all so nice and helped to keep me calm."
"…express my appreciation for you exceptional skill and professionalism during surgery…appreciation to your staff, whose courtesy and detailed explanations of the procedure were excellent."
"….wanted you to know that your nurses and office personnel were very courteous and helpful… your receptionist, even though fielding numerous phone calls with grace, scheduled an appointment for me while handling many calls in the order received… I very much appreciate her manner."


text:
Ties with China looming over Indo-Japan naval relations
Japan's navy chief, Admiral Katsutoshi Kawano said Tuesday, indicating that cagey Sino-Indian ties were weighing down naval relations between New Delhi and Tokyo.world Updated: Apr 23, 2014 23:00 IST
The Indian Navy is willing but the reluctance of the government is preventing an upswing in Indo-Japan naval ties, Japan's navy chief, Admiral Katsutoshi Kawano said Tuesday, indicating that cagey Sino-Indian ties were weighing down naval relations between New Delhi and Tokyo.
"India has a very good navy and we want to engage more closely," Kawano said.
Kawano said Japan was ready with its technology and equipment to cooperate with the Indian Navy. In fact, India is set to become the first country since the Second World War to buy the US-2 amphibious military aircraft from Japan.
That could be just the beginning, the Japanese navy chief said, adding: "We are very interested in helping India develop its naval technology.''
Concerned about China's rising naval power and fast expanding maritime reach, Kawano said he wants the navies of Japan and India to interact more frequently and develop close links in the Indian Ocean.
Asked about China's fast expanding naval power, he said: "We are very concerned about it". He said China will have a large armed force because it is a big country with more than 1 billion people but Japan too has lot of plans to expand the navy.
On India-Japan naval relations, Kawano said: "As I understand, the Indian Navy is keen and willing. But Indian politics is very complicated," Kawano said, indicating that Japan was waiting for a broad positive response from the Indian government about deepening engagement between the armed forces.
Kawano spoke to HT on-board India's first indigenous stealth frigate, INS Shivalik which sailed to the Qingdao port in eastern China to take part in a multi-lateral naval exercise to mark the 65th year of the founding of People's Liberation Army (PLA) navy.
Admiral Kawano, who is the Chief of Staff, Japan's Maritime Self-Defence Force, said: "We very frequently hold exchanges with the Indian navy. We want to do much more. We have been wanting to join very much the Malabar sea exercises with the United States and India. We also want to do a bilateral exercise with India," Kawano said.
Besides India, ships from Bangladesh, Brunei, Indonesia, Malaysia, Pakistan and Singapore participated in the exercise, held off the Qingdao coast on Wednesday.
Earlier, China snubbed Japan by not inviting Japanese ships to the exercise and announcing that the PLA navy chief, Wu Shengli, will not meet Kawano or any Japanese navy officials during the ongoing Western Pacific Naval Symposium in Qingdao. Tension is running high between the two countries over the ownership of a cluste of islands in the East China Sea.
In January, the Indian the defence ministry had given the go-ahead to invite Japan for the next Indo-US Malabar exercises, held off the Indian coast.
In 2007, China had formally protested when Japan was invited to the Malabar exercise, prompting a decision by the government that India would not take part in military exercises that could be perceived to be positioned against another country.
Admiral Kawano had visited New Delhi in January and had met defence minister, AK Antony and the then Indian navy chief, DK Joshi, discussing issues like combating piracy off the Gulf of Aden.


text:
Deuteronomy 6:6-7King James Version (KJV)
6 And these words, which I command thee this day, shall be in thine heart:
7 And thou shalt teach them diligently unto thy children, and shalt talk of them when thou sittest in thine house, and when thou walkest by the way, and when thou liest down, and when thou risest up.
Psalm 119:9-11King James Version (KJV)
9 Wherewithal shall a young man cleanse his way? by taking heed thereto according to thy word.
10 With my whole heart have I sought thee: O let me not wander from thy commandments.
11 Thy word have I hid in mine heart, that I might not sin against thee.
1 Timothy 5:14King James Version (KJV)
14 I will therefore that the younger women marry, bear children, guide the house, give none occasion to the adversary to speak reproachfully.
2 Timothy 3:15-17King James Version (KJV)
15 And that from a child thou hast known the holy scriptures, which are able to make thee wise unto salvation through faith which is in Christ Jesus.
16 All scripture is given by inspiration of God, and is profitable for doctrine, for reproof, for correction, for instruction in righteousness:
17 That the man of God may be perfect, thoroughly furnished unto all good works.
You'll get this book and many others when you join Bible Gateway Plus. Learn more


text:
Working at Farm Credit is more than a job, it's a way of life. Our employees are committed to our customers' success. We offer a work environment that demands your best, and in return delivers interesting work, co-workers who care and operate with integrity, and meaningful contributions to an essential industry. Our employees have the opportunity every day to demonstrate their passion for agriculture, their commitment to rural America and their dedication to delivering exceptional performance.
As the nation's leading financial resource for agriculture, Farm Credit stays on the cutting edge of technology, evolving business practices and emerging trends. This means we offer a wide variety of challenging opportunities to build and expand your professional experience. While Farm Credit hires many employees with training in credit and finance, we also need people with skills in other specialized areas, such as crop insurance, appraisal services, information technology, human resources and marketing.
Find a career with Farm Credit today, or browse our career categories to learn more about the types of job opportunities we offer. Career areas vary by location.
Changes in the agricultural sector are affecting the value of agricultural assets—land, equipment and grain inventories—that show up on farmers' balance sheets, and will have an impact on owners' equity and working capital. Read More »
Nothing is better for college students to help bolster their resume than real-world experience in their chosen field. Farm Credit and the National Agri-Marketing Association (NAMA) have teamed up for the third straight year up to deliver an exciting professional development opportunity to a select group of agricultural communications students who will collect and distribute original content on NAMA's Facebook, Twitter and Instagram channels during the 2016 Agri-Marketing Conference. Apply now for the opportunity to join the 2016 NAMA Social Media Corps! Read More »
In 2011, Heather Gibson was introduced to Farm Credit at the AFA Leaders Conference. She interned with American AgCredit in Wichita, Kan. after she earned a bachelor's degree in agribusiness from Kansas State University. Next, she began her graduate studies in agricultural economics to Kansas State, and American AgCredit offered her a full-time job opportunity. Read More »
Farm Credit is a proud support of the AgChat Foundation through the National Contributions Program. The AgChat Foundation empowers farmers, ranchers and other agvocates to connect through social media platforms and has built the highly visible #AgChat community on Twitter. Read More »


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My husband isn't the type of person who likes stuff. He has books and he has some classical music CDs, but his wants are few, and this makes shopping for him very tricky. I love him and would enjoy piling presents under the tree for him, but what do you give someone who doesn't want anything? When asked, he'll say things like, "I have you. What more could I want?" While that's really terribly romantic, and he gets major husband points for that, it doesn't help when it comes to celebrating the holidays.
If you've got a person like this in your life, you might consider some of the things I've found useful in solving this gift-giving dilemma.
1. Get them a gift certificate to a store that sells things they are interested in. True, a gift certificate isn't the most personal thing in the world, but it will allow your hard-to-shop-for loved one the chance to get something they'd really like.
2. Consider that perhaps they really don't want more stuff, and instead, give them an experience. Take them to a show or a concert. If they're a really special loved one, follow that up with a nice dinner. This way, they have a beautiful memory to share with you, but not an item that's going to gather dust on a shelf.
3. Think about a time you shared together and find them a gift that reminds you of that time. If you and your husband went to Paris on your honeymoon, find him a framed picture of Paris or a little statue of the Eiffel Tower. It's fun to commemorate those special moments in your life.
4. To go along with this idea, you might consider making them a special scrapbook filled with pictures of things you've done together. Next to the pictures, write down how that event touched your heart and how grateful you are that you could share it with them.
The holidays mean different things to different people. I feel guilt when I don't give the perfect gift, but it really doesn't matter to my husband. Really think about that special person in your life. Could it be that you want them to celebrate in your way, when they just want to celebrate in their own way? Think of the holiday from their point of view, and maybe the perfect solution will present (ha ha, like the pun?) itself.
Related Blogs:
The Most Wonderful Time of the Year
Inexpensive Holiday Gifts: Time


text: Hi I came across this tweed SC on ebay and it really appeals to me. The tweed looks yum, it has 3 patch pockets, basically it has everything I am looking for .... But it is used and cheap and I have no idea of fit, so logically I should pass. What do you think of it ? Does it look dated / odd etc. Anything wrong with it ? Regards


text:
For Bonbébé it's all about quality, taste and products that are perfectly tailored to the different growth stages a baby goes through. When preparing the baby meals and snacks only the best ingredients are good enough, to ensure the meals are full of vitamins, minerals and other nutrients that are important for the growth of your baby. Bonbébé Menu Spaghetti Bolognese is nutritious and delicious and contains important vitamins, minerals and other nutrients that your baby of 15 months and up needs for a good growth.
Usage and Storage
How to use: If the lid of the jar 'clicks' when opening it when you press it before opening it for the first time, don't use the food. Scoop out the food with a plastic spoon. Stir the food well and checkt the temperature before serving it to your child.
Storage advice: After opening, the jar can be stored in the fridge for maximum 48 hours. Warmed jars can not be stored.
How to prepare
Microwave (600 Watt): Warm the unopened jar for 40 seconds. Make sure the food doesn't boil.
Au bain-marie: Warm the unopened jar a couple of minutes in a pan with hot, but not boiling water.


text: واحد من اقوي البرامج لتشغيل أفلام الدي في دي ذات إمكانيات صوتيه ومرئيه عااليه ويدعم ملفات الام بي ثري و الواف والميديا و يدعم الكثير من الصيغ المرئيه و الصوتيه منها .. DVD-Video / SVCD / Video-CD / Audio-CD / DVDonCD(cDVD?cdDVD? miniDVD) / DTS-CD / DivX Videofile / AC3 / AVI / ASF / CDDA / DAT / M1V / M2V / MID / MP2 / MP3 / MPEG / MPG / RMI / VOB / VRO / VRO / WAV / WM / WMA / WMV 10.0.2.701.51 151.18 Mb See layers of movie detail like never before with movies in Blu-ray 3D. PowerDVD 10 brings the magic of Blu-ray 3D to your PC, providing you with the ultimate movie experience. Enjoy stunning HD quality in 3D as PowerDVD 10 delivers the maximum 1080p resolution to each eye. Broad 3D support: PowerDVD 10 delivers Blu-ray 3D to any compatible 3D displayand supports all 3D video file formats. The Universal Player that Upgrades Your Media Experience to 3D and HD - Immerse in amazing depth and realism with Blu-ray 3D playback - CPU/GPU acceleration for smooth playback. Lossless HD audio quality for maximum enjoyment - Convert DVDs and videos into lifelike 3D experience - Play broad range of video formats: MKV, FLV, 3GP, AVCHD, AVCREC, and more - Supports the latest audio formats: Dolby; TrueHD, Digtial EX, Plus, DTS-HD - Make movies social: share bookmark reviews and live comments - Includes TrueTheater Stabilizer and Noise Reduction Available Languages: English, Chinese Traditional, Japanese, Spanish, Korean, Chinese Simplified, German, French, Italian and Russian Preactivated Recompressed Setup: - Installs the Mark II Ultra Max Version, pre-activated & pre-registered - The MoovieLive, Remix and the Comment features are disabled by default - Sets the cursor hide time in Full Screen to 1 second (default = 3 sec) - Unlocks DVD-Audio (MLP) support + TruSurround XT & TSXT Headphone Mode TruSurround XT is the second generation of SRS TruSurround. Building upon its patented predecessor and namesake,TruSurround XT not only solves the problem of playing 5.1 or 6.1 multichannel content over two speakers or headphones, but also utilizes proprietary algorithms from SRS Labs - Dialog Clarity and TruBass - to provide listeners with a truly immersive audio experience. TruSurround XT accepts input from up to a 7 channel (6.1) audio source and processing a 2 channel output. When receiving multichannel content, TruSurround XT virtualizes the channels, creating ''phantom'' speakers that appear to extend all around the listener, producing an amazing surround sound effect. When receiving mono or stereo content, TruSurround XT includes the functionality of SRS WOW to present an expansive three dimensional sound field. Changelog build 2701: Issues resolved: - CyberLink PowerDVD cannot play back the ''MACROSS F MOVIE'' Blu-ray Disc title. - CyberLink PowerDVD cannot play back disc two of the ''Beauty and the Beast'' Blu-ray Disc title. - CyberLink PowerDVD cannot enable hardware acceleration during the playback of videos with .WTS file extension. - CyberLink PowerDVD cannot navigate DVD content that has been ripped. - CyberLink PowerDVD cannot jump to different moments of a video by clicking along the navigational slider, when playing a file with the .M2TS file extension. - Users cannot activate the Ultra version of CyberLink PowerDVD if the standard version was previously installed. - Revision made to the ''drive authentication fails'' warning message encountered during playback. Install: Just run Setup.exe and you are done, it's registered and activated. Note: This Setup does not install the PowerDVD Toolbar (Mini Player Mode) If you want to use it then extract the Tweak Pack and run Enable_Toolbar.bat Note about virus warnings: If you get a trojan or virus warning then it's a false positive! - I've added nothing!! You get exactly the same warning when you download and install the retial version because it's the same setup. I only removed and modified some files to disable MoovieLive, Movie Remix and RichVideo and to make it pre-activated! Here's how to check the Digital Signatures: - Extract Setup.exe with 7-zip and open the directory where you extracted the files - Right click on an exe file, select properties and click on the Digital Signatures tab - Double click on the Signature and read the line below ''Digital Signature Information'' - If it says that the Digital Signature is OK, it means that the file isn't altered! - Click on the ''View Certificate'' button for more information Note: You can update all my releases, the only con is that it will ask to register. Just enter a phony name + email address, and the reminder won't popup anymore. Tweak Pack for PowerDVD 10: Blu-Ray_Region_Reset.bat: Resets the Blu-Ray region settings (remaining changes) Disable_BD_Mouse_Pop-up.bat: Disables the Blu-Ray disk Mouse support Pop-up Enable/Disable_3DFeature.bat: Enables/Disables the 3D Feature Enable/Disable_MoovieLive.bat: Enables/Disables MoovieLive, Remix and Comment features Enable/Disable_CinemaMode.bat: Enables/Disables the Cinema Mode Enable/Disable_CLFLVSplitter.bat: Enables/Disables the FLV Splitter * Reset_HD_Dailog.bat: Resets the High-Definition Content dialog ** Remove/Restore_StartupApps.bat: Removes/Restores the Startup Applications *** Enable/Disable_Toolbar.bat: Enables/Disables the PowerDVD Toolbar (Mini Player Mode) Enable/Disable_Upgrade.bat: Enables/Disables the Upgrade Popups and Buttons -)--- CLFLVSplitter.ax can cause a crash when you play flv videos in Windows Media Player: Disable_CLFLVSplitter.bat unregisters the FLV Splitter, which fixes the problem * -)--- This comes in handy if you selected ''Don't ask me this question again'' and want to re-enable or disable TrueTheater Lightning and Smart De-interlace when playing High-Definition content ** -)--- Removes the Startup Apps BDRegion and RemoteControl10 - Don't run this if you use a remote! موقع البرنامج / Program Page إضغط هنا / Click Here


text:
LEM - The Learning Museum Network
LEM - The Learning Museum started as a three years EU funded project in 2010 with 23 partners from 17 European countries and the United States of America. It had the objective to establish a permanent network and web space for museums and adult educators interested in museum and heritage education, intercultural dialogue and lifelong learning.
LEM's underlying philosophy is to consider museums not only as learning places, but learning organisations themselves: learning from the communities, from the public, from their stakeholders, and also from other agencies, with whom they build alliances to accomplish the ambitious objectives set by policies at national and European level and meet the challenges of the future decades.
When the EU funding ended in October 2013, LEM had 62 additional associate partners which continued to grow during the following months. At the end of 2014 LEM was incorporated into NEMO to become a permanent Working Group called "Learning Museum" with the aim to maintain and expand the network and continue the research and exchange activities carried out in the past.
Additional information on LEM, its history and activities in the past can be found here.
LEM Working Groups and Reports
During its lifetime, LEM established five Working Groups to research specific subjects and encourage the encounter of and the exchange of information among museum professionals in Europe. Each working group produced one or more reports which are downloadable.
The subjects researched and the reports produced are:
New trends in the museums in the 21st century
Report 1: The Virtual Museum
Report 7: New trends in museums of the 21st century
Museums and the ageing population
Report 2: Heritage and the Ageing population
Audience research, learning styles and visitor relation management
Report 3: Measuring Museum Impacts
Report 5: Technology and the public. Evaluation of ICT in museums
Report 6: Audience research as an essential part of building a new permanent exhibition. Stories from the field
Learning facilities and learning spaces in museums
Report 8: Learning Facilities and Learning Spaces in Museums
Intercultural dialogue
Report 4: Museums and Intercultural Dialogue
In addition to its report, the Intercultural Dialogue Working Group has produced in collaboration with the National Cinema Museum of Turin a short film "Shells. Museum for learning. Museum for living.", which shows the many ways a visitor can experience a museum and rediscover his own past.
Mobility and study visits
The LEM network attached great importance to peer learning and established a Mobility Scheme where some partners agreed to host colleagues interested in spending between some days and two weeks in their organisation, for job-shadowing or study visits during the project lifetime (Read a study visit report).
In addition, all Working Groups undertook several study visits to further the knowledge of the researched subject by travelling to places where good practices could be seen in a real work situation.
The idea of learning in a real setting and experiencing other colleagues' practices remains unchanged as LEM becomes a permanent Working Group under NEMO's umbrella.
Learn more about the activities of NEMO's working group LEM - The Learning Museum here.


text:
Just in time for Daytona Bike Week, Allstate Insurance announced the details of four custom-built bikes that will be on display during the Florida motorcycle event. These motorcycles are the result of the very first collaborative effort between three famous bike builders – Rick Fairless, Dave Perewitz and Arlen Ness. Each bike has a special focus on rider safety and protection
"These four beautiful and elaborate creations tell a unique story about out motorcycle product, industry innovations and rider advocacy efforts," said Keith Ruthman, vice president of Allstate's Consumer Household department. "All of these attributes – including safety, customization and advocacy – aim to make the world a better place to ride."
Ness built two bikes for the project, one of which is a 2012 Victory Cross Country that will be used for a sweepstakes giveaway that fans can enter online or at any rally where the bikes will be on display. Fairless' custom motorcycle promotes the Allstate Once is Never Enough (ONE) program that is designed to encourage rider safety on the road. The bike built by Perewitz features a Kicker sound system and custom artwork by Keith Hanson.


text:
I was interested in Aquamid for crow's feet rather than Botox. Would this be a good option?
Aquamid Vs. Botox for Crow's Feet?
Doctor Answers 7
Botox or Aquamid for Crow's Feet
Hi Aussie in Beautiful Melbourne,
Crow's feet are best treated with Botox. "Line" fillers should not be used in this area because of the dynamic muscles. Volume fillers such as your own fat or Sculptra may help by replacing lost volume.
Stay away from Aquamid anywhere in your body. The product has been associated with severe infections in many cases.
Good day,
Dr. P
Avoid Aquamid
Because of the nature of our practice, we see many patients from Europe. We have unfortunately already operated on several unhappy Aquamid patients. Unfortunately, the Aquamid had infiltrated into the tissues and only a partial correction was possible.
The Aquamid seems to behave much like silicone. I would personally put it in the category of the worst of the worst. Just my opinion.
Aquamid vs. Botox for Crows feet
In general, Botox is the best treatment for the crows feet because these wrinkles are the result of underlying muscle contraction.
Fillers are not appropriate for the Crows feet because of the significant degree of movement of this area in combination with thin skin which frequently results in lumpiness. I would strongly discourage you from having Aquamid injected to your Crows feet since Aquamid is a permanent filler (not yet FDA approved in the US). Crows feet wrinkles can be significantly improved with a combination of Botox and laser or chemical peel resurfacing.
Good luck and be safe.
You might also like...
Aquamid and fillers
Dr. Karamanoukian
Learn more: http://www.kareplasticsurgery.com/revision/silicone-removal/
Management options for crows feet
Hello ~
I would not recommend an injectable filler for correction of crows feet as a first line treatment. A chemodenervation agent, such as Botox or Dysport would be a first line treatment. In patients who have static rhytids or wrinkles that are present both in the presence and absence of animation, a resurfacing treatment may be beneficial in conjuction with the chemodenervation agent. Common treatments include chemical peels, such as TCA, and fractionated lasers. Consult with a Board Certified Plastic Surgeon to find out what treatment would best suit your needs.
Best ~
Glenn Vallecillos, M.D., F.A.C.S.
Learn more: http://www.beverlyhillscosmeticsurgeon.com/fillers-injectables.php
Use Botox for Crow's feet!
Aquamid is a filler for deeper tissues.
Crow's feet are primarily a problem caused by repeated muscle contraction and not by true or relative soft deficits .
Botox is the preferred and more targeted approach to managing crow's feet.
Treatment of Crow's Feet
There is a great deal of confusion regarding the appropriate use of fillers (such as Aquamid) and Botox.
Botox is the brand name for a product naturally produced by a bacteria. The product disables the movement of facial muscles. By stopping the muscle from moving, it allows wrinkles to smooth out over time. Botox has no filling effect.
By contrast, fillers fill the space under the wrinkle making it less noticeable. The muscles will still move normally. Examples of fillers are ArteFill, Aquamid, Restylane, Perlane, Hylaform, Radiesse, Sculptra, Elevess, Evolence, Prevelle, Juvederm, Collagen, etc.
Although Botox is sometimes used in the lips and chin, it generally works best in the upper face (forehead, between the eyebrows, crow's feet, etc.).
By contrast, fillers are generally best in the lower face (nasolabial folds, lips, jowls, etc.)
Please keep in mind that Aquamid is considered a permanent filler and should be used cautiously. Currently, Aquamid is not FDA approved in the USA.
We generally recommend our patients to undergo treatment with a temporary filler to make sure they like the result.
We subsequently treat them with ArteFill which is a permanent filler currently FDA approved in the USA with a good track record and excellent results.
IMPORTANT: When selecting a qualified plastic surgeon, make sure that they are certified by "The American Board of Plastic Surgery". This is the only board recognized by "The American Board of Medical Specialties" in the field of plastic surgery.
Unfortunately, there are many unqualified individuals out there posing as plastic surgeons, who prey on uninformed consumers. Checking their credentials is the best way to protect yourself.
Good luck with your treatment.
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


text:
found a new home!
Plenty of my friends are looking
for one too. Find a pet to adopt.
I am already neutered and up to date with shots.
Sterling is a neutered male, Domestic Short Hair black and white, 2 to 4 years old.
Sterling was pulled from a high kill shelter. He was pelted with B-B's and left for dead in a State Park. Sterling is a very affectionate kitty and loves everyone even with what was done to him. He is a loving companion to his 3 legged pal also at the shelter.
Sterling is completely vetted and is looking for his forever home preferably with his pal Trey who is a tripod.
Contact foster at 810-632-6885 or email email@example.com for any further questions. Please can you give these 2 a home together. Sterling and Trey are soul survivors and are bonded.
Sterling, a Howell Domestic Shorthair cat was adopted! Here's how you can benefit by looking at adoption as an option to buying a Domestic Shorthair for sale in Howell, or seeking a Domestic Shorthair cat from a breeder in Howell.


text:
Sean Hannity is leaving New York. We know this because the Fox News host put his underground bunker on the market.
Hannity's home has been listed for $3.6 million, his listing agent told Newsday. That doesn't include the slave quarters.
He will be resettling in Texas or Florida, his second and third choices. A wing nut compound in Idaho was first choice but the confederacy refused to make him their King.


text:
The version information file <project>_private.rc can only be
modified through Project Options|Version info. But i would like to
define the version number in only one place, either for the
"StringFileInfo" section and the dialog boxes.
So for each
release, the new release number has to be changed in only one
Currently, it seems not be possible.
Log in to post a comment.


text:
User:Kristian Ullrich
From OpenWetWare
Revision as of 02:58, 1 November 2013 by Kristian Ullrich (Talk | contribs)
Contact Info
- Kristian Ullrich
- www.labutils.de
- Email me through OpenWetWare or through firstname.lastname@example.com
- 2013 - Scientific coworker in the group of Stefan Rensing plantco.de
- 2012-2012 Short visit in the group of Dirk Inzé System biology of yield
- 2009-2012 PhD in the group of Marcel Quint Quint Lab
- 2008 Diplom (~MSc), Christian-Albrechts-University Kiel, Institue of Molecular Phytopathology (D. Cai Lab)
- 2001-2008 study of Biology at the Christian-Albrechts-University Kiel
Research interests
plant genetics
- phytohormone signaling
- natural variation
- population genomics
software development
- Image processing
- Optimized probe masking for comparative transcriptomics of closely related species. (Pöschl Y, Delker C, Trenner J, Ullrich KK, Quint M, Grosse I) (submitted)
- Toward a comprehensive phylogenetic reconstruction of the evolutionary history of mitogen-activated protein kinases in the plant kingdom. (Janitza P, Ullrich KK, Quint M) frontiers in PLANT SCIENCE 2012 Dec 06.
- A transcriptomic hourglass in plant embryogenesis. (Quint M, Drost H-G, Gabel A, Ullrich KK, Boenn M, Grosse I) Nature 2012 Oct 04.
- Natural Variation of Transcriptional Auxin Response Networks in Arabidopsis thaliana. (Delker C, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M) Plant Cell. 2010 Jul 9.
- Molecular Evolution and Selection Patterns of Plant F-box Proteins with C-terminal Kelch Repeats. (Schumann N, Navarro-Quezada AR, Ullrich K, Kuhl C and Quint M) Plant Physiology Preview 2010 Nov 30.


text:
A Phase I Study of LJM716 in Squamous Cell Carcinoma of Head and Neck, or HER2+ Breast Cancer or Gastric Cancer
This study has been completed.
Novartis Pharmaceuticals
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )
ClinicalTrials.gov Identifier:
First received: May 4, 2012
Last updated: April 21, 2014
Last verified: April 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study has been completed.
|Study Completion Date:
|March 2014
|Primary Completion Date:
|March 2014 (Final data collection date for primary outcome measure)


text:
This spacious family villa with partial sea views is well positioned with a sunny south orientation, in a quiet residencial neighbourhood close to the sandy beach of Cala Vinyas. A beautiful and well maintained garden invites you to spend time on the open and covered terraces, perfect for entertaining, or lying by the pool. The villa offers the following layout: an impressive entrance, kitchen with dining area, spacious lounge with formal dining all flowing out to the terraces. On this level there is also a laundry, guest wc and garage parking. Stairs lead up to the bedroom level where there is a master bedoom suite with a private terrace enjoying distant views to the bay of Palma. Additionally there are three further bedrooms suites, one of them enjoying space for a sitting area or office. Features of the villa include h/c air conditioning, electric radiators, garage parking plus additional parking for a further two cars.
Availability upon agreement.
This material is based upon information, which we consider reliable, but because third parties have supplied it, we cannot represent that it is accurate or complete, and it should not be relied upon as such. This offering is subject to errors, omissions, and change of price or withdrawal without notice. Taxes, notary and register fees must be paid by purchaser, the commission by the seller as stipulated by Spanish regulations.


text:
Saracens' Billy Vunipola was named the Premiership's discovery of the season at last night's end-of-season awards dinner.
The 21-year-old has enjoyed an excellent season both club and country, helping Saracens to the Premiership semi-finals and a first-ever Heineken Cup final, whilst earning his first five caps for England.
Vunipola claimed the gong at the Premiership's end-of-season awards dinner at the Hilton Hotel on Park Lane last night, with director rugby Mark McCall also recognised for another superb season at the helm at Allianz Park.
Jacques Burger was beaten to the Premiership player of the season award by Mike Brown of Harlequins.