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Who says you have to leave Bucks County to have some summer fun? Check out our ultimate list of spectacular summer events happening right here in Bucks!
Recurring Summertime Events
Annual Summertime Events
Summer Festivals and Fairs
Outdoor Family Fun
Summer Shopping
Outdoor Dining
Recurring Summertime Events
Rose Bank Wine Concert Series
Shady Brook Farm, 931 Stony Hill Road, Yardley
Who doesn't love wine, food, and a concert? Shady Brook Farms is once again hosting the Rose Bank Wine Concert series on Friday nights from 6:00pm till 9:00pm until the end of August. Bring the whole family to hear great local bands, enjoy wine tasting by Rose Bank Winery, and relax on the beautifully landscaped E.P. Henry patio. crackers, cheeses, chips and dips from our Farm Market, and sandwiches from our full service Deli, or grab a burger or dog hot off the grill. There is a playground for the children, and Uncle Dave's Homemade Ice Cream will be open for business. Wine will be sold by the glass or by the bottle.
The Grapevine Express
New Hope & Ivyland Railroad, 32 West Bridge Street, New Hope
Join them for a Romantic Wine and Cheese Excursion at 5:00pm on Saturdays and Sundays May 26th thru October 28th. Ride the rails in first class comfort in our beautifully restored, air conditioned Parlor Car for a 50 minute tour. Enjoying fine cheeses, toasted crackers and exclusive vintages from various regions. Each month a different region will be featured.
Evening Stars Dinner Trains
New Hope & Ivyland Railroad, 32 West Bridge Street, New Hope
Passengers can ride the rails in first class comfort, enjoying dinner and cocktails while appreciating the strolling scene provided by the Bucks County countryside. Check out the New Hope & Ivyland Railroad website for more information.
Murder Mystery Dinner Trains
New Hope & Ivyland Railroad, 32 West Bridge Street, New Hope
The New Hope & Ivyland Railroad and Act 1 Productions bring you another season of mystery on the rails. An edge-of-your-seat, whodunit evening of suspense and comedy! The wild 40's cast of Act 1 Productions is at it again with a new act for 2012 called "Muriel's Murder". Another comedic murder mystery, sure to make you laugh and be on the edge of your seats with a whodunit murder mystery. Food, fun, great staff, rolling ride through the country and the antics of Act 1 Productions all combine to give you and your family a great night out. Check out the New Hope & Ivyland Railroad website for more information.
New Hope/Lambertville Friday Night Fireworks
New Hope/Lambertville Bridge
Friday Night Fireworks display of the wonderful Delaware River every night from Memorial Day weekend until the end of August. Orchestrated by Garden State Fireworks, a glittering ten-minute firework show will illuminate the sky over the Delaware River for the summer season. In addition, most retail businesses on both sides of the river will stay open late. Fireworks start at 9:30pm.
2012 Summer Wine & Music Series
Crossing Vineyards and Winery, 1853 Wrightstown Rd, Washington Crossing
Starting on Friday, June 8th, join Crossings Vineyards and Winery for their summer Wine & Music Series! They will be featuring 7 all-time favorite performances along with a brand new one! These events start at 7:00pm and is rain or shine. You should also bring a lawn chair for your comfort. Seating is available for buffet diners and there will also be wine and cheese available for purchase.
Sesame Street Concert Series
Sesame Place, 100 Sesame Road, Langhorne
Come join your Sesame Street friends for a variety of concerts this summer! With a variety of family-friendly performances, there is something for everyone! Click on the link above to find out when all the these fantastic concerts are happening.
Doylestown Sounds of Summer Series
Lenape Middle School, 313 West State Street, Doylestown (rain location)
The Sounds of Summer Series returns yet again for another wonderful season of music. Performers both new and old are returning to play your favorite songs. Check out their Doylestown Summer Guide for more information about who is playing and exact times!
Cruise Nights 2012
Shady Brook Farm, 931 Stony Hill Road, Yardley
Rev your engines for Shady Brook Farm's Cruise Night! ALL cruisers are welcome to participate or just come and check out all the cars every Tuesday from 6:00pm – 9:00pm. There will be 10 general trophies, 5 special theme night trophies weekly, free admission, 50/50, music, playground for kids, food, drinks, and ice cream available.
Summer Concert Series 2012
Falls Township Community Park, Phase I Pavilion, 9125 Miller Creek Rd, Levittown.
All Summer Concerts are held at the Falls Township Community Park, Phase I Pavilion, 9125 Miller Creek Road in Levittown from 6:00pm – 8:00PM. Bring your own chair
Movies in the Park
Linton Park, South Lincoln & Penn, Newtown
Live music will be performed before each movie. Music starts around 8 p.m. and the movies begin at dark. These events are sponsored. Here's the 2012 schedule:
June 20: "The Muppets" (PG), music: Evan King
June 27: "Scooby Doo" (PG), music: Cowpals
July 11: "Beetlejuice" (PG), music: Peter Joseph
July 18: "Rear Window" (PG), music:Brianna Nelson/Katie Marshall
July 25: "The Wizard of Oz" (G), music: Trevor Leonard
August 1: "Tangled" (PG), music: Keith Monacchio
Annual Summertime Events
May & June
Annual Civil War Encampment
Mercer Museum, 84 South Pine Street, Doylestown
Saturday, May 26th (10:00m – 4:00pm); Sunday, May 27th (12:00pm – 4:00pm)
Visit with military engineers and map makers, join the ranks of new recruits answering the President's call for troops to defend the Union, learn about Civil War era medicine, and interact with local civilians. Various demonstrations and activities scheduled throughout the day. Rain or Shine. Program helps mark the American Civil War Sesquicentennial – five years of programming and exhibits commemorating the 150th anniversary of the War. Presented in collaboration with the 50th Pennsylvania Volunteers – an historical interpretation and re-enacting unit. Included with museum admission.
Antique Appraisal Night
Craven Hall, Street Rd & Newtown Rd, Warminster
June 1st (6:30pm – 9:00pm)
Professional appraisers will review your items at $8 each or $20 for 3 items (maximum). This successful event can be considered a mini Bucks County Antiques Road Show. Find what your treasure is worth! Barry S. Slosberg, Inc, Auctioneers / Appraisers of Philadelphia have been in business for four generations and have generously given of their time & talent to support Craven Hall Historical Society, Inc. for this memorable event.
Tyler Tasting Party
Tyler Mansion, 275 Swamp Road, Newtown
June 1st (6:30pm – 10:00pm)
Join Bucks County Community College for their annual Tyler Tasting Party, a premier food and wine tasting event. This event raises funds for students enrolled in the College's Historic Preservation Program, and to restore and maintain Tyler Hall, the French-Norman style mansion on the National Register of Historic Places and cornerstone of the Newtown campus. The growth of this event over the years, which annually attracts more than 500 people, remains a source of pride to the Foundation.
Little Girl's Tea
Craven Hall, corner of Street and Newtown Roads, Warminster
June 2nd (1:00pm – 3:00pm)
Craven Hall will host a special tea, just for young ladies aged 6-11. Their favorite dolls are also invited! Cookies, pastries, finger sandwiches, and tea will be served in the splendor of this gracious mansion. Presentations by period-dressed guides will add to this fun event. Youngsters can design their own hat, provided by Craven Hall, to wear to the tea. Colonial games and a craft project are also planned. The cost of the tea is $20 per child. Dolls are admitted for free. An adult must accompany all children. Light refreshments will be served to mom or dad who must remain at Craven Hall for the duration of the tea.
2012 Fine Art & Contemporary Crafts Show
Peddler's Village , Lahaska
June 2nd – 3rd (10:00am – 6:00pm)
This juried outdoor exhibition features a variety of original artwork including paintings, drawings, photographs, sculpture, jewelry, and contemporary crafts. Cash prizes awarded in three categories; "Fine Art", Contemporary Crafts", and "Photography". Live entertainment and children's activities.
Legacy Sweepstakes & Lawn Party
Mercer Museum, 84 South Pine Street, Doylestown
June 24th (4:30pm – 6:00pm)
Will you be the lucky winner of the 27th annual Mercer Legacy Sweepstakes? The lucky Grand Prize Winner will choose between a new car from Thompson BMW and $20,000. Our Second Prize Winner will receive a $750 VISA gift card from Monument Bank. Third prize is a $500 gift certificate to Bucks Country Gardens. Legacy Sweepstakes entries costs $100 and only 600 will be sold. In addition, each entry entitles you and a guest to enjoy refreshments, entertainment, and a silent auction at the Legacy lawn party, sponsored by Thompson BMW and Monument Bank. All proceeds from the sweepstakes support educational programs at the Mercer Museum and Fonthill Castle.
Concert Under the Stars
Tinicum Park, 963 River Road Upper Black Eddy
June 30th (gates open at 6:00pm, concert begins at 8:00pm)
Happy Birthday America! Join us and celebrate with an unforgettable evening of light classical, popular, and patriotic music under the stars at scenic Tinicum Park along the Delaware River. Over the years, the Concert Under the Stars has become an increasingly popular holiday tradition and quintessential Bucks County experience! So bring a picnic, bring your family, bring your friends, and enjoy a spectacular Independence Day celebration! Purchase tickets for this Happening List finalist here!
July & August
Fonthill's Old-Fashioned 4th of July Celebration
Fonthill Museum, East Court Street & Route 313 , Doylestown
July 4th (12:00pm – 5:00pm)
Experience "the good-old days" as Fonthill recreates an early 20th century July Fourth Celebration. Festivities include a decorated bike parade, a town ball game (19th-century baseball), a watermelon eating contest, free old-time games and live music. Food available. Gate tickets: $4 adults, $2 members, $1 youth (age 5-17) , Free children (4 and under). For more information, call 215-348-9461 or email: [email protected]
32nd Annual Revoluntionary Run
Washington Crossing Historic Park
July 4th (Registration starts at 6:00am)
Join the Upper Makefield Business Association in conjunction with the Upper Makefield Township as they sponsor the 32nd Annual Revolutionary Run! This run begins in Washington Crossing Historic Park, out and back along the scenic Delaware River. Along with the 5k fitness run is a 1 mile fun run. Be aware of the weather because this run is rain or shine!
Discovery Day
Bowman's Hill Wildflower Preserve, 1635 River Road, New Hope
July 14 (10:00 a.m. to 4:00 p.m)
Bowman's Hill's 13th annual Discovery Day is the perfect time for you, your family and friends to have your "Mind, Heart and Spirit Bloom" at the Preserve. This free community event is an opportunity for all ages to experience a sampling of what the Preserve has to offer. rain or shine. Guided wildflower walks offered throughout the event will take you on a stroll through the heart of our meadow, filled with brilliant native perennials and grasses and beautiful butterflies.
Kids Triathlon
Central Bucks Family YMCA, 2500 Lower State Road, Doylestown, PA 18901
August 5 (6:30am – 12:00pm)
Registration is now open for our award winning (Bucks Happening List "Best Summer Event") Kids Triathlon. Competitive categories begin at age 6 and modified divisions are available for age 3-5. Click here for Kids Tri webpage. Contact Rachel Mauer for details, 215-348-8131, x1143.
Farm to Table (Heritage Conservancy)
Lindsay Farm, Warminster
August 4th (5:00pm – 8:30pm)
Join Heritage Conservancy for the award winning, 4th Annual Farm to Table event held at the preserved Lindsay Farm. There will be locally grown food prepared by acclaimed chefs from Earl's Bucks County & Jamie Hollander Gourmet served in a rustic and picturesque outdoor setting.
55th Annual New Hope Auto Show
New Hope-Soluebury High School
August 11th – 12th (9:00am – 4:00pm)
The New Hope Automobile Show has become a showplace for the magnificent antique and classic automobiles that compete. This year the show is limited to just 250 vehicles per day. So to ensure your place on the field, be sure to register early. Remember, all vehicles must register in advance. Admission to the show is $5.00 per person. $3.00 for Senior Citizens 62 and over, children under 12 accompanied by an adult are free. Active duty military and dependents are free. Parking is $5.00.
Annual Beer Event: A World of Beer
Fonthill Castle, East Court Street & Route 313 , Doylestown
August 17th (7:00pm – 10:00pm)
Celebrate and drink local! This year's annual beer event will celelbrate a world of beer! Local breweries and homebrewers will provide a tasting of their creations inspired from brewing techniques used in many different areas of the world. Music and light fare included. The cost is $35 for non-members, $28 for members. Registration is required. To register for the event, you can call (215) 348-9461 or send an email [email protected]
Summer Festivals & Fairs
Sycamore Street Summerfest 2012
Sycamore Street, Newtown
June 2 (12:00pm – 9:00pm)
With the theme of "Takin' It to the Street", the Sycamore Street Summerfest is a family fun event to kick off the summer in Newtown with local vendors, great food, face painting, and more! This event will feature the Summerfest as well as the Corvette Show from 1:00pm – 7:00pm and the Strawberry Festival from 12:00pm – 4:00pm.
Strawberry Festival
Shady Brook Farms, 931 Stony Hill Road, Yardley
June 9th – 10th & 16th – 17th (11:00am – 4:00pm)
Take a wagon ride to the patch to pick-your-own strawberries. Inflatable attractions, samples, and more! FREE admission, berries sold by the pound.
Delaware Canal Festival
Bristol, New Hope, Yardley, and Morrisville
June 22nd through June 24th
Celebration of Freedom
Peddler's Village, Lahaska
June 30th (4:00pm – 10:00pm)
Join Peddler's village in their annual "Celebration of Freedom." Live entertainment, children's acitivities, and picnic-style favorites await you are this patriotic event. Fireworks will be displayed at 9:15pm and will be accompanied by music courtesy of Signature DJs. Admission is free.
Southampton Days
1255 Second St. Pike, Southampton (between Tamanend Park and Klinger Middle School)
July 2nd – 7th
Events provide fun for the whole family. Games, rides and entertainment for small children. Rides and entertainment for teens. Bands for teens and adults along with food, crafts, children's games and bingo for everyone. The event is organized so that other community organizations can raise funds and advertise their services. By providing our community organizations the opportunity to promote their organization, everyone in our community can benefit.
Tinicum Arts Festival
Tinicum Park, 963 River Road, Upper Black Eddy
July 14th (10:00am – 6:00pm), July 15th (11:00am – 5:00pm)
A Great Bucks County Tradition, the Tinicum Arts Festival returns to the shady grounds of Tinicum Park. Gather with friends and neighbors to enjoy the works of over 180 regional artists in the centerpiece Art Barn. Delight in the creations of over 130 artists and craft artisans displayed under the trees. Discover treasures at the White Elephant Tent. Choose from literally thousands of volumes at the Book Wagon. Place a bid at the Silent Auction. Enjoy outstanding live musical entertainment while savoring a fresh-squeezed lemonade, a tasty sandwich or a home-baked desert in the picnic grove. Special activities for children and summer fun for everyone at the Tinicum Arts Festival.
Peach Festival Featuring the Annual Sidewalk Sale
Peddler's Village, Lahaska
August 11th – 12th (10:00am – 6:00pm)
Come enjoy various peach treats throughout the Village while taking advantage of sizzling savings in every shop. Enjoy musical entertainment throughout the weekend. Parking and festival admission is free!
Peach Festival
Shady Brook Farm, 931 Stony Hill Road, Yardley
August 12 (11:00am – 4:00pm)
Since 1949, features fun for the entire family including children's activities, entertainment, rides, music, commercial vendors, exhibit, plus a wide variety of food and attractions. Due to the weather during last year's fair, there may be significant changes to the fair this year. Admittance to the fair is a $10 per vehicle per day. Sunday will be a $5 fee for the day per vehicle. There is also a 5 day pass available for $30. Check out the website for more information.
Outdoor Family Fun
Open Air Theatre
The Washington Crossing Open Air Theatre, produced by the Downtown Performing Arts Center of Lambertville, New Jersey, features a full season of musicals, plays, children's theatre and "First Monday Movies" from June through October. Shows and movies can be seen on Friday, Saturday, Sunday and the first Monday of each month all summer long. For a full list of all the great shows they will be bringing to their outdoor stage this year, check out their website.
For anyone looking for a great hike or just to spend some time in the sunshine, Bucks County has a multitude of parks to visit. Along with our own park guide, there are many parks with family friendly fun, such as Central Park that has what is known as Kids Castle, an eight story wooden playground structure designed and named by children of Doylestown Township through an art contest. For the Bucks County super walkers, there is a Delaware Canal State Park with its canal trail.
Delaware River Tubing, the closest and most inexpensive river tubing, rafting, kayaking, and canoeing outfitter in the tri-state area. Each river rental includes a free BBQ meal at "The Famous River Hot Dog Man" while tubing, rafting, kayaking, or canoeing down the river.
Honey Hollow has several hiking trails (open daily from 9am-5pm), as well as an educational center, hosting various classes & field trips.
The flying trapeze, nighttime rafting, and more! Looking to do something a bit more adventurous than relaxing by a pool this summer? Lucky for you, Bucks County is chock-full of fun adventures! Check out six local activities to help you get your summer adventure fix.
Summer Shopping
Rice's Market is a 30 acre outdoor market open on Tuesdays and Saturdays. Vendors come from all around, as they have for over 100 years, to sell their goods. Some things you can expect to find are antiques and collectibles, jewelry, fresh fruits and vegetables, Amish meats and baked goods, clothing, and handbags. On a typical market day, Rice's will host as many as 700 vendors!
263 Marketplace Indoor Shoppers Village
700 York Rd, Warminster
This indoor shopper's village opened in November 2010 and features over 60 stores. Here are some of the products you can find here: antiques, apparel, awnings, eyewear, carpets and flooring, children's boutique items, collectibles, cookware, flea market, jewelry, kitchenware, locksmith, local items, motorcycle apparel, sports memorabilia, and tee shirts. They also have a live auction.
Penn's Purchase
5861 York Rd, Lahaska
Penn's Purchase Factory Stores is not just a great shopping destination; it's also a great place to spend the day. Whether with family, friends, or just by yourself, Penn's Purchase Factory Stores is a great getaway and easy to get to from anywhere. Come for the shopping, stay for the day.
Peddler's Village
Routes 202 & 263, Lahaska
Peddler's Village has something for everyone from 70 specialty shops and six restaurants to the luxurious 70-room Golden Plough Inn and Giggleberry Fair family entertainment center. We invite you to celebrate favorite traditions at our 11 annual festivals and events. The Hospitality Center is staffed and ready to serve you, whether you need maps, directions, reservations, gift certificates or other information. When visiting, stop at the Peddler's Village Hospitality Center in the lobby of the Cock 'n Bull Restaurant (#54).
Outdoor Dining
One of the best ways to maximize the summer sun is by finding the best restaurants with outdoor seating. Here are a few places with outdoor accommodations that we have reviewed with outdoor seating. Even if you are looking for a place to keep cool from the summer heat, you can check out Restaurant Guide for more selections!
Anton's at the Swan
Bobby Simone's
The Black Bass Hotel
Cross Cultures
Green Parrot
Hamilton Grill Room
It's Nutts
Issac Newton's
Lambertville Station
Martine's River House


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(dox ay' zoe sin)
P : Caution when used during pregnancy
L : Caution when used during lactation
Molecule Info
|| See TERMINOLOGY & ABBREVIATIONS |
Doxazosin indications-
Doxazosin is indicated for the treatment of hypertension and can be used as the sole agent to control blood pressure in the majority of patients. In patients inadequately controlled on single antihypertensive therapy, Doxazosin may be used in combination with a thiazide diuretic, beta-adrenoceptor blocking agent, calcium antagonist or an angiotensin-converting enzyme inhibitor.
Benign prostatic hyperplasia: Doxazosin is indicated for the treatment of urinary outflow obstruction and symptoms associated with benign prostatic hyperplasia (BPH). Doxazosin may be used in BPH patients who are either hypertensive or normotensive.
Dosage & Administration
Doxazosin may be administered in the morning or the evening.
Hypertension: Doxazosin is used in a once daily regimen: the initial dose is 1mg, to minimise the potential for postural hypotension and/or syncope. Dosage may then be increased to 2mg after an additional one or two weeks of therapy and thereafter, if necessary to 4mg. The majority of patients who respond to Doxazosin will do so at a dose of 4mg or less. Dosage can be further increased if necessary to 8mg or the maximum recommended dose of 16mg.
Benign prostatic hyperplasia: The recommended initial dosage of Doxazosin is 1mg given once daily to minimise the potential for postural hypotension and/or syncope (see section 4.4). Depending on the individual patient's urodynamics and BPH symptomatology dosage may then be increased to 2mg and thereafter to 4mg and up to the maximum recommended dose of 8mg. The recommended titration interval is 1-2 weeks. The usual recommended dose is 2-4mg daily.
Children: The safety and efficacy of Doxazosin in children have not been established.
Elderly: Normal adult dosage.
Patients with renal impairment: Since there is no change in pharmacokinetics in patients with impaired renal function, the usual adult dose of Doxazosin is recommended.
Doxazosin is not dialysable.
Patients with hepatic impairment: There are only limited data in patients with liver impairment and on the effect of drugs known to influence hepatic metabolism (e.g. cimetidine). As with any drug wholly metabolised by the liver, Doxazosin should be administered with caution to patients with evidence of impaired liver function
Should overdosage lead to hypotension, the patient should be immediately placed in a supine, head down position. Other supportive measures may be appropriate in individual cases.
If this measure is inadequate, shock should first be treated with volume expanders. If necessary, vasopressor should then be used. Renal function should be monitored and supported as needed.
Since Doxazosin is highly protein bound, dialysis is not indicated.
Doxazosin is contraindicated in:
1) Patients with a known hypersensitivity to quinazolines (e.g. prazosin, terazosin, doxazosin), or any of the excipients
2) Patients with a history of orthostatic hypotension
3) Patients with benign prostatic hyperplasia and concomitant congestion of the upper urinary tract, chronic urinary tract infection or bladder stones.
4) During lactation (for the hypertension indication only, see section 4.6: Fertility, pregnancy and lactation)
5) Patients with hypotension (for benign prostatic hyperplasia indication only)
Doxazosin is contraindicated as monotherapy in patients with either overflow bladder or anuria with or without progressive renal insufficiency.
Special Precautions
Postural Hypotension/Syncope:
Initiation of Therapy - In relation with the alpha-blocking properties of doxazosin, patients may experience postural hypotension evidenced by dizziness and weakness, or rarely loss of consciousness (syncope), particularly with the commencement of therapy (see section 4.2: Posology and method of administration). Therefore, it is prudent medical practice to monitor blood pressure on initiation of therapy to minimise the potential for postural effects.
When instituting therapy with any effective alpha-blocker, the patient should be advised how to avoid symptoms resulting from postural hypotension and what measures to take should they develop. The patient should be cautioned to avoid situations where injury could result, should dizziness or weakness occur during the initiation of Doxazosin therapy.
Use in patients with Acute Cardiac Conditions:
As with any other vasodilatory anti-hypertensive agent it is prudent medical practice to advise caution when administering doxazosin to patients with the following acute cardiac conditions:
- pulmonary oedema due to aortic or mitral stenosis
- high-output cardiac failure
- right-sided heart failure due to pulmonary embolism or pericardial effusion
- left ventricular heart failure with low filling pressure.
Use in Hepatically Impaired patients:
As with any drug wholly metabolised by the liver, Doxazosin should be administered with particular caution to patients with evidence of impaired hepatic function (see section 4.2: Posology and method of administration). Since there is no clinical experience in patients with severe hepatic impairment use in these patients is not recommended.
Use with PDE-5 Inhibitors:
Concomitant administration of doxazosin with phosphodiesterase-5-inhibitors (eg sildenafil, tadalafil, and vardenafil) should be done with caution as both drugs have vasodilating effects and may lead to symptomatic hypotension in some patients. To reduce the risk of orthostatic hypotension it is recommended to initiate the treatment with phosphodiesterase-5-inhibitors only if the patient is hemodynamically stabilized on alpha-blocker therapy. Furthermore, it is recommended to initiate phosphodiesterase-5-inhibitor treatment with the lowest possible dose and to respect a 6-hour time interval from intake of doxazosin. No studies have been conducted with doxazosin prolonged release formulations.
Use in patients undergoing cataract surgery:
The 'Intraoperative Floppy Iris Syndrome' (IFIS, a variant of small pupil syndrome) has been observed during cataract surgery in some patients on or previously treated with tamsulosin. Isolated reports have also been received with other alpha-1 blockers and the possibility of a class effect cannot be excluded. As IFIS may lead to increased procedural complications during the cataract operation current or past use of alpha-1 blockers should be made known to the ophthalmic surgeon in advance of surgery.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Chest pain, fatigue, headache, influenza-like symptoms, pain, hypotension, palpitation, abdominal pain, diarrhoea, nausea, oedema, dizziness, dry mouth, somnolence, dyspnoea, respiratory disorders, vision abnormalities, impotence, urinary tract infection, increased sweating, anxiety, insomnia. Vertigo, orthostatic hypotension, arrhythmia, hypotension, arthralgia/arthritis, muscle weakness, myalgia, kinetic disorders, ataxia, hypertonia, muscle cramps, flushing, tinnitus, sexual dysfunction, rhinitis, epistaxis, polyuria, urinary incontinence, fatigue/malaise, face oedema.
Drug Interactions
Decreased hypotensive effect with NSAIDs. Increased hypotensive effect with alpha-blockers, diuretics, ACE inhibitors, calcium-channel blockers.
Pregnancy Category (US FDA)
Use during pregnancy: As there are no adequate and well-controlled studies in pregnant women, the safety of Doxazosin during pregnancy has not yet been established. Accordingly, during pregnancy, Doxazosin should be used only when, in the opinion of the physician, the potential benefit outweighs the potential risk. Although no teratogenic effects were seen in animal testing, reduced foetal survival was observed in animals at extremely high doses. These doses were approximately 300 times the maximum recommended human dose.
Use during lactation:
Doxazosin is contraindicated during lactation as animal studies have shown that doxazosin accumulates in milk of lactating rats, and there is no information about the excretion of the drug into the milk of lactating women. The clinical safety of Doxazosin during lactation has not been established, consequently Doxazosin is contra-indicated in nursing mothers.
Use during breast-feeding: Alternatively, mothers should stop breast-feeding when treatment with doxazosin is necessary
Mechanism of Action
Doxazosin is a potent and selective post-junctional alpha-1-adrenoceptor antagonist. This action results in a decrease in systemic blood pressure. Doxazosin is appropriate for oral administration in a once daily regimen in patients with essential hypertension.
Doxazosin has been shown to be free of adverse metabolic effects and is suitable for use in patients with coexistent diabetes mellitus, gout and insulin resistance.
Doxazosin is suitable for use in patients with co-existent asthma, left ventricular hypertrophy and in elderly patients. Treatment with Doxazosin has been shown to result in regression of left ventricular hypertrophy, inhibition of platelet aggregation and enhanced activity of tissue plasminogen activator. Additionally, Doxazosin improves insulin sensitivity in patients with impairment.
Doxazosin, in addition to its antihypertensive effect, has in long term studies produced a modest reduction in plasma total cholesterol, LDL-cholesterol and triglyceride concentrations and therefore may be of particular benefit to hypertensive patients with concomitant hyperlipidaemia.
Administration of Doxazosin to patients with symptomatic BPH results in a significant improvement in urodynamics and symptoms. The effect in BPH is thought to result from selective blockade of the alpha-adrenoceptors located in the muscular stroma and capsule of the prostate, and in the bladder neck.
Absorption: Following oral administration in humans (young male adults or the elderly of either sex), doxazosin is well absorbed and approximately two thirds of the dose is bioavailable.
Biotransformation/Elimination: Approximately 98% of doxazosin is protein-bound in plasma.
Doxazosin is extensively metabolised in man and in the animal species tested, with the faeces being the predominant route of excretion.
The mean plasma elimination half-life is 22 hours thus making the drug suitable for once daily administration.
After oral administration of Doxazosin the plasma concentrations of the metabolites are low. The most active (6' hydroxy) metabolite is present in man at one fortieth of the plasma concentration of the parent compound, which suggests that the antihypertensive activity is in the main due to doxazosin.
There are only limited data in patients with liver impairment and on the effects of drugs known to influence hepatic metabolism (e.g. cimetidine). In a clinical study in 12 subjects with moderate hepatic impairment, single dose administration of doxazosin resulted in an increase in AUC of 43% and a decrease in apparent oral clearance of 40%. As with any drug wholly metabolised by the liver, Doxazosin should be administered with caution to patients with impaired liver function.
ATC Classification
C02CA04 - doxazosin; Belongs to the class of alpha-adrenoreceptor antagonists, peripherally-acting antiadrenergic agents. Used in the treatment of hypertension.
Search Google: Doxazosin
Brand/Product Info
|Brand Name
|Dosage Form
|Pack Size & Price
Gen. MedInfo
Why Doxazosin is prescribed?
Doxazosin is used in men to treat the symptoms of an enlarged prostate, which include difficulty urinating, painful urination, and urinary frequency and urgency. Doxazosin is also used alone or in combination with other medications to treat high blood pressure. Doxazosin is in a class of medications called alpha-blockers. It relieves the symptoms of BPH by relaxing the muscles of the bladder and prostate. It lowers blood pressure by relaxing the blood vessels so that blood can flow more easily through the body.
How should Doxazosin be used?
Doxazosin comes as a tablet and an extended-release tablet to take by mouth. The doxazosin tablet is usually taken with or without food once a day in the morning or in the evening. The doxazosin extended-release tablet is usually taken once a day with breakfast. To help you remember to take doxazosin, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your Doctor to explain any part you do not understand. Take doxazosin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Swallow the extended-release tablets whole; do not split, chew, or crush them.
Your doctor will start you on a low dose of doxazosin and gradually increase your dose, not more than once every 1 to 2 weeks. If you stop taking doxazosin for a few days or longer, consult your doctor. Your doctor will have to start you again on the lowest dose of doxazosin and gradually increase your dose.
Doxazosin controls high blood pressure and the symptoms of BPH but does not cure them. It may take a few weeks before you feel the full benefit of doxazosin. Continue to take doxazosin even if you feel well. Do not stop taking doxazosin without talking to your doctor.
Other uses for Doxazosin
This medication may be prescribed for other uses; ask your Doctor for more information.
What Special Precautions to follow?
Before taking doxazosin,
- inform your Doctor if you are allergic to doxazosin, prazosin, terazosin, or any other medications.
- inform your Doctor what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antihistamines; clarithromycin; ipratropium; itraconazole; ketoconazole; medications for erectile dysfunction such as sildenafil, tadalafil, or vardenafil; medications for high blood pressure; medications for HIV/AIDS including atazanavir, indinavir, nelfinavir, ritonavir, or saquinavir; medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or urinary problems; nefazodone; telithromycin; and voriconazole. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- inform your doctor if you have angina; low blood pressure; or if you have or have ever had prostate cancer or liver disease. If you are taking the extended-release tablet, tell you doctor if you have constipation, short bowel syndrome, or narrowing or a blockage of the intestines.
- inform your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking doxazosin, consult your doctor.
- talk to your doctor about the risks and benefits of taking doxazosin if you are 65 years of age or older. Older adults should not usually take doxazosin because it is not as safe as other medications that can be used to treat the same conditions.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking doxazosin. If you need to have eye surgery at any time during or after your treatment, be sure to inform your doctor that you are taking or have taken doxazosin.
- you should know that doxazosin may make you drowsy or dizzy. Do not drive a car, operate machinery, or perform dangerous tasks for 24 hours after the first time you take doxazosin or after your dose is increased.
- you should know that doxazosin may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking doxazosin, when your dose is increased, or if your treatment has been stopped for more than a few days. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. If you experience these symptoms, sit or lie down. If these symptoms do not improve, consult your doctor.
What special dietary instructions to follow?
Follow your doctor's directions for your meals, including advice for a reduced salt diet.
What to do if I forget a dose?
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. Check with your doctor if you have missed two or more doses.
What side effects can this medication cause?
Doxazosin may cause side effects. Tell your doctor if any of these symptoms or those listed in the SPECIAL PRECAUTIONS section are severe or do not go away:
- headache
- tiredness
- swelling of the hands, feet, ankles, or lower legs
- shortness of breath
- weight gain
- muscle or joint pain or weakness
- abnormal vision
- runny nose
- decreased sexual ability
- rapid, pounding, or irregular heartbeat
- chest pain
- shortness of breath
- hives
- painful erection of the penis that lasts for hours
Some side effects can be serious. If you experience any of these symptoms, consult your doctor immediately:
Doxazosin may cause other side effects. Consult your doctor if you have any unusual problems while taking this medication.
What Storage conditions are needed for this medicine?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture. Throw away any medication that is outdated or no longer needed. Talk to your Doctor about the proper disposal of your medication.
In case of emergency/overdose
In case of overdose, consult your Doctor. If the victim has collapsed or is not breathing, consult local medical emergency services.
Symptoms of overdose may include:
- drowsiness
- dizziness
- lightheadedness
- fainting
- seizure
What other information should I know?
If you are taking doxazosin extended-release tablets, you may notice something that looks like a tablet in your stool. This is just the empty tablet shell, and this does not mean that you did not get your complete dose of medication.
Keep all appointments with your doctor. If you are taking doxazosin to control high blood pressure, your blood pressure should be checked regularly to determine your response to doxazosin.
Do not let anyone else take your medication.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
This information is provided for reference only and not a replacement for and should only be used in conjunction with full consultation with a registered medical practitioner. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, mph-bd shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise.

subset: commoncrawl


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A Study of Commercial DEFINITY® to Monitor the Effects of the Heart's Pulmonary Artery Pressure
- Full Text View
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Pulmonary Heart Disease
|Drug: Definity
|Phase 4
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
|Official Title:
|A Phase IV, Open-Label Safety Evaluation of the Effect of DEFINITY® on Pulmonary Artery Hemodynamics in Patients With Normal and Increased Pulmonary Artery Pressure
- Percent Change in Pulmonary Artery Pressure Change From 1 Minute Pre-dose to 31 - 35 Minutes Post Dose [ Time Frame: 31-35 minutes minus baseline ]Percent change in pulmonary atery pressure change from immediately pre-dose to 31 - 35 minutes post dose
- Immunology Panel- Complement 3A (C3A) [ Time Frame: Out to 70 minutes ]Evaluate the Immunology Panel after the administration of DEFINITY
- Immunology Panel- Complement 5A(C5A) [ Time Frame: Out to 70 minutes ]Evaluate the Immunology Panel after the administration of DEFINITY
- Immunology Panel- Interleuken-6 [ Time Frame: Out to 70 minutes ]Evaluate the Immunology Panel after the administration of DEFINITY
- Immunology Panel- Tryptase [ Time Frame: Out to 70 minutes ]Evaluate the Immunology Panel after the administration of DEFINITY
|Study Start Date:
|July 2009
|Study Completion Date:
|December 2009
|Primary Completion Date:
|December 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Low Pulmonary Arterial Pressure
Subjects with pulmonary arterial pressure (PAP) of < or = to 35 mmHg.
Drug: Definity
one bolus dose of Definity per intravenous injection, 30-60 second injection, dose value calculation = maximum of 10 microliter/kg patient weight
Other Name: Perflutren Lipid Microsphere
Experimental: Elevated Pulmonary Arterial Pressure
Subjects with a PAP of > or = to 35 mmHg.
Drug: Definity
one bolus dose of Definity per intravenous injection, 30-60 second injection, dose value calculation = maximum of 10 microliter/kg patient weight
Other Name: Perflutren Lipid Microsphere
Detailed Description:
This Phase IV safety study will provide safety data on potential systemic and pulmonary hemodynamic effects caused by the administration of DEFINITY® in patients who are to undergo right heart cardiac catheterization for clinical reasons. Using a right heart catheter for direct measurements of pulmonary artery hemodynamics will allow accurate assessments of potential alterations of the pulmonary vasculature. This will be further investigated by the inclusion of two patient populations, one with a baseline pulmonary artery pressure < 35 mmHg, and one with elevated baseline pulmonary artery pressure. The addition of immune parameter measurements will assess a potential link between systemic and pulmonary alterations and potential immune reactions following DEFINITY® administration.
The inclusion of patients in this study is not based on a required echocardiogram with DEFINITY® administration because patients would be exposed to an unjustifiable risk of invasive right heart catheterization and are unlikely to consent to such a procedure. Therefore, patients undergoing heart catheterization for clinical reasons, or patients who are undergoing pulmonary artery hemodynamic assessments will be enrolled and receive DEFINITY® in this study.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Appropriate candidate scheduled to undergo right heart catheterization and measurement of pulmonary artery hemodynamics for clinical reasons
- Be male or female above the age of 18
- Female patients who no longer have child-bearing potential
Women of Child-Bearing Potential(WOCBP) who:
- are not pregnant and have been using an adequate and medically approved method of contraception
- have a negative urine pregnancy test
- Be able and willing to communicate effectively with study center personnel.
Exclusion Criteria:
- Women who are pregnant or lactating
- Known hypersensitivity or contraindication to or greater heart block
- Previous heart transplant
- Known right-to-left shunt (including atrial septal defect)
- Severe pulmonary artery hypertension (i.e., > 75 mmHg
- Current uncontrolled ventricular tachycardia
- Second-degree or greater heart block
- Any contraindications for the use of a right heart catheter
Please refer to this study by its ClinicalTrials.gov identifier: NCT00918866
|United States, Illinois
|Northwestern Memorial Hospital
|Chicago, Illinois, United States, 60611
|University of Chicago Medical Center
|Chicago, Illinois, United States, 60637
|United States, Minnesota
|Methodist Hospital
|St. Louis Park, Minnesota, United States, 55426
|United States, Missouri
|Cardiovascular Consultants
|Kansas City, Missouri, United States, 64111
|United States, New Jersey
|Holy Name Hospital
|Teaneck, New Jersey, United States, 07666
|United States, Ohio
|The Cleveland Clinic Foundation
|Cleveland, Ohio, United States, 44195
|United States, Oregon
|Oregon Health and Sciences University
|Portland, Oregon, United States, 97239
|United States, Texas
|The University of Texas Medical Branch at Galveston
|Galveston, Texas, United States, 77555
|Study Director:
|Veronica Lee, MD
|Lantheus Medical Imaging
|Responsible Party:
|Lantheus Medical Imaging
|ClinicalTrials.gov Identifier:
|NCT00918866 History of Changes
|Other Study ID Numbers:
|Study First Received:
|June 4, 2009
|Results First Received:
|December 17, 2010
|Last Updated:
|March 30, 2015
Keywords provided by Lantheus Medical Imaging:
Phase 4
pulmonary artery pressure
Additional relevant MeSH terms:
Heart Diseases
Pulmonary Heart Disease
Cardiovascular Diseases
ClinicalTrials.gov processed this record on September 19, 2017


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While analysts are forecasting a slowdown for most Latin American economies in 2013, Bombardier–in its 20-year forecast released in June this year–expects to see an improved market in 2014 and believes that as early as 2016, the Canadian manufacturer will "surpass its prior delivery peak year of 2008."
Most of that growth will come from the company's large-cabin, ultra long-range line of business jets: the Global 6000; and the new Global 7000 and Global 8000, due for certification in 2016 and 2017, respectively. Bombardier's analysts expect key growth markets, including Brazil, to receive "a significant share of business jet deliveries during the next 20 years."
As a mark of its growing regional market, Bombardier sponsored its fourth "Safety Standdown Latin America," held in São Paulo over the two days preceding LABACE 2013. It was open to all the region's business jet operators and their service teams, suppliers, maintenance technicians and partners.
Earlier this year, in January, Bombardier's ultra long-range Global 6000 received certification by the Agência Nacional de Aviação Civil. With that approval, Bombardier's full line of Learjet, Challenger and Global business jets now has Brazilian certification.
Dassault sold its first business jet in Brazil in 1978, according to Dassault Falcon president and CEO John Rosanvallon, who claims the French OEM holds a 66-percent share of the large-cabin business jet market. "We've seen countries like Brazil become the epicenter of business aviation's recovery over the past several years," Rosanvallon declared last August at LABACE 2012. "The elements remain in place for continued business aviation growth, and increased Falcon market share in Brazil."
He emphasized that success also means servicing and supporting what the company sells and, as a result, Dassault Falcon continues to expand its Dassault Service Center in Sorocaba, about 80 kilometers (50 miles) west of São Paulo. The center is now certified to work on U.S.-, Bermuda- and Argentina-registered Falcons as well as those registered in Brazil, and has EASA approval. The facility is also supported by approximately $2 million in high-usage parts.
Embraer claims Brazil as home ground and the company's large-cabin Legacy 600, Legacy 650 and Lineage 1000 combined fleet in Latin America now totals 30 aircraft, all but two in service in Brazil. "Embraer Executive Jets is seeing a growing demand for larger, longer-range aircraft worldwide," said executive jets president Ernie Edwards. "Sales of the Legacy 650, for instance, are going well in China, Asia Pacific and Latin America, and we see sweet spots in each region."
While the Legacy 650 doesn't have the legs of its Bombardier, Dassault and Gulfstream competitors, it does have a large cabin and nonstop range from São Paulo to Miami or Cape Town, South Africa. Certification of the new Legacy 500 is expected in 2014 and, while officially a mid-size business jet, Edwards sees it as "a game changer," with nonstop range from São Paulo to Panama City or Freetown Sierra Leone.
This year at LABACE, Embraer has staked out a chalet (No. 5115) large enough to accommodate one of each of its larger aircraft, including the Legacy 500, Legacy 650 and Lineage 1000.
As with other manufacturers with a growing presence in Latin America, Embraer has begun expanding its service and support in the region. In March last year, it announced an agreement with the state of São Paulo that will see the addition of a 19,950-sq-m (215,000 sq ft) service center at Bertram Luiz Leupolz Airport in Sorocaba. Construction of the $25 million facility will be carried out over the next five years.
Gulfstream isn't on its home field in Latin America, but the Savannah, Georgia-based company views the region as something of a personal market playground. "We have about a 45-percent market share in the large-cabin category, from the Gulfstream IV through Gulfstream 650," said senior regional v-p Roger Sperry. "And we're looking at ways to gain more." In Latin America, he said, "Our installed base was 90 aircraft in 2008, and as of June 1 that number was 176 and growing." More than half of that number is based in Brazil and Mexico.
Sperry noted the growing number of large-cabin customers who are not only based in Latin America, but are doing business there from distant locals. "I cover Asia as well and it's amazing the number of customers there who are doing business in Latin America. There is no business today that is not global, and if you're expanding, you're expanding outside your region," he added.
He also pointed to the fact that Mexico, Brazil and Venezuela are buying more mid-cabin business jets than anywhere else globally. "Today, we have 2,159 Gulfstreams around the world, and eight percent of them are in Latin America."
And Gulfstream is not merely selling airplanes in Latin America, said Sperry. As far back as 2009, the OEM realized that supporting and servicing what you sell is key to a successful program in the long term and it designated Jet Aviation in Sorocaba, Brazil, as a repair facility. With sales growing, and with Jet Aviation owned by Gulfstream parent company General Dynamics, the Sorocaba center was rebranded as Gulfstream Brazil in June last year.
Of the more than 175 Gulfstreams in service in Latin America today, 70 are large-cabin, long-range and ultra long-range business jets of the GIV size and larger. So, it should be no surprise that the Sorocaba facility has grown to a full-fledged service center capable of heavy maintenance work, from airframe inspections to engine changes.
In fact, the growth of service and support facilities at Bertram Luiz Leupolz Airport by the various OEMs is indicative of the growth of business aviation in Latin America, and in particular in Brazil. "And based on conversations with our customers," concluded Gulfstream's Sperry, "we expected a lot more people to attend the show from outside Brazil."
In all, it spells good news for the sale of large-cabin business jets in Latin America well into the future, and for the continued growth of the LABACE event.


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HONEST Salisbury City boss Mikey Harris is fully aware of the exciting opportunities the January transfer market offers but is in no rush to adjust his successful squad.
The shopping window is set to be used at full capacity by many clubs across the country, including sides with sizeable budgets in the non-league scene.
But the City leader remains levelheaded on what the Old Sarum club can realistically spend over the next few weeks.
"We'll see what's available," Harris stated.
"Obviously there are a few players I've got my eye on but whether we'll be able to bring them in remains to be seen. It's important we're sensible in terms of our budget and if we are bringing players in, then there maybe need for movement out.
"We'll assess the situation and look to improve the squad if we need to. But, as I said in my programme notes on Saturday, I don't believe wholesale changes are necessary.
"Everyone can see we have a squad here that works hard and is achieving a relative amount of success. For me it's about subtle improvements here and there."
One of the wealthiest clubs in the division, likely to be splashing out, is Forest Green Rovers, City's opponents today (3pm), pending a pitch inspection at 9.30am.
They will head to Gloucestershire on the back of some impressive results and with more players set to return from injury.
The 29-year-old added: "It's going to be a very difficult game."
"They've got a quality squad of players and their manager has an abundance of options available.
"It's a game we'll look forward to as the rivalry between the two clubs is well documented and hopefully we can pick up a positive result."
The meeting in November was a horror show for City, who were hammered 4-1 on the night, with England C striker James Norwood pulling the strings.
And Norwood, with ten goals to his name, is a player Harris knows his team will have to deal with.
"He's a dangerous player on his day and one we know plenty about. We'll certainly have to keep him quiet if we want to be successful."
Potentially making their Forest debuts today are Crystal Palace loanee Jerome Binnom-Williams and veteran striker Lee Hughes.
- Salisbury travel to FC Halifax Town on Tuesday night (7.45pm) in a rearranged fixture.


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A message to biotech start-ups, scientist-entrepreneurs and life sciences organizations banking on your exciting protein-based drug-discovery programs and technologies: When it comes to the timing of your investment, if you don't pay now, you might pay (much) more later.
Outsourced Pharma spoke with service providers about the decision-making process regarding the timing of crucial—and at times hefty—investments in development and production of proteins. Above all, they stress the decision to put your money to work upfront or hold off investment until further clinical validation will follow you for a long time.
Investment strategy will influence the timing and progress—or in some cases, lack of progress—of your overall program. It can also affect your chances for out licensing down the road (more on that later). This may not be a unique business conundrum, but for an early-stage life sciences company, the risk-reward stakes are high.
In A Hot Space (And The Hot Seat)
The promise of biologics investigation and ultimately commercial biopharmaceuticals and biosimilars is driving innovative platforms and technologies for protein research and reagents, purification and expression, and development and manufacturing advancements. There is a palpable elevation in motivation at both the scientific and C-suite level to move protein-based programs into the pipeline.
According to Genetic Engineering and Biotechnology News, the three top-selling drugs in 2013 were biologics: AbbVie's Humira with global sales reaching $10.65 billion; J&J/Merck's Remicade at $8.94 billion, and Genentech/Biogen Idec's Rituxan at $8.92 billion. Cellcutluredish.com reports 8 of the top 15 best selling drugs in 2013 were biologics. Paul Bridges, worldwide head of Parexel Consulting, has said that by 2016 he expects even more biologics such as protein-based drugs will populate the top 10 list.
The promise of the role of proteins in new drug development has been a long time coming. For example, years ago, a first wave of monoclonal antibodies (MAbs) were disappointments, both clinically and economically. Some drug makers invested in expensive manufacturing infrastructure for a demand that failed to materialize.
Today as well, the reality and the hope can clash in the lab and clinic. Protein-based drug companies of all sizes look to rapidly identify a robust host strain that can be sufficiently and reliably scaled for production. Identifying a host strain producing high titers of soluble, active protein is critical to minimize long-term cost of goods, and avoid potential regulatory delays due to poor quality or insufficient productivity of the selected host. The hope is to meet analytically rigorous specifications of protein quality, yield, and potency that lead to the rapid development of a clinical and commercial stage manufacturing process.
But companies must decide relatively early in the process if a significant investment should be made or not. Opinions differ, and we are told, are often based on an individual decision-maker with some past experience. For all early stakeholders, though, and for potential partners and suitors, risks and their mitigation options need to be clearly understood.
Option 1: Limit Upfront Financial Risk
No surprise the first option regarding protein production is to take the least expensive approach—and usually the one of least internal resistance—early in the process. Despite initial enthusiasm for new programs, funds may be low, and as we all know failure in the clinic is an unfortunate but common part of the business.
Minimizing instrument and equipment purchases, streamlining contracts with providers, and limiting time spent on robust development and quality testing can save significant upfront investment dollars and still provide the requisite amount of material to conduct initial clinical trials. In a relatively short amount of time and limited cash outlay, a company potentially gains enough data to bolster internal interest if competing for dollars with other programs, provide fodder for VC investment, and gain visibility for shopping-out a program to pharma or other potential acquirers or partners.
There are risks, though. The most obvious is that the protein, lacking further study before heading to trial, may not meet desired quality or safety attributes. This could, in fact, negatively bias the trial, in a way setting yourself up for failure (instead of doing everything to gain initial success). As troubling, this quick-and-easy approach could result in a substance profile that then differs at later phase study. It may also preclude the best production process for a steady supply of material in the future.
However, some startups or academia-based investigators may feel they have no choice; they simply do not have the funding to do otherwise at an early stage. Moreover, some companies (big and small) are primarily looking for verification that the protein will perform as expected. Perhaps borrowing a page from the "fail fast" approach of their small molecule brethren, if the protein doesn't perform as expected, companies can opt out of the program quickly without significant investment. Holding onto the purse strings can, in hindsight, look like a wise management and business decision if the program fails.
Another "positive" here is that less-than-desired initial results in the clinic might point the way to adjustments in strategy, such as moving to a promising backup program. And as mentioned above, even with the protein under-performing, there is at least some potential the increased program visibility and additional data might entice a partner with a similar program and/or deeper pockets.
Hopefully, though, positive results are returned from the clinic. At this point, companies may find it easier to fund requisite toxicology study and further process and development work to move to initial human trials. Now no compromise on quality can be in the thought process, and the scaling up of production of material is also a major consideration.
However, since this first option is more a fear of failure than a plan for success, there is the potential that even good results can have an unfortunate side. If the protein is not of sufficient titer, quality, or scalable under stringent cGMP standards, you might need to re-engineer a cell line or strain. Providers of these services tell us it is not unusual to have to repeat studies just performed to demonstrate attributes of the new material. This going-back-to-go-forward scenario can end up a larger financial burden than companies would have carried upfront. Of course, there is no guarantee the next trial returns more favorable results.
There is a final calculus for this option of least investment upfront. It is the expectation that the program will be acquired or partnered, so any subsequent investments for development et al. will be picked up by another company. Indeed, this is why funding is done in rounds and is a common business strategy in many industries: Get through proof of concept and then bring in more dollars.
But again, kicking the investment can down the road could have unintended financial repercussions. For one thing, the program may look riskier to a potential big pharma acquirer, who will discount the need for further investment when negotiating a licensing or purchasing deal. Conversely, savvy pharma will see the inherent value in a program that has taken on upfront costs and taken out more uncertainty. There is recoverable value in marketing a robust program for a high quality cell line or strain. And this brings us to Option 2.
Option 2: Risk Investing Early And Plan For Success
Many of the pros and cons for making upfront initial investments actually came out directly above. Fundamentally, you invest more early to ensure your best shot on goal in your initial trials and subsequent partnering activities. You enter the game with a better-known protein of higher quality and potential for robust scalability. You aim for results you can take major advantage of in your next phases, and if it is part of the strategy, at the negotiating table.
A provider we spoke with pointed to perhaps the weightiest of factors. "Although there are many considerations on many levels when making this decision, it ultimately comes down to perceived success for the project. If you believe the product you're working on is going to be successful, you should consider making the appropriate investment upfront and saving yourself money, time, and effort down the line." And, we might add, if you don't have that faith, why should potential investors or partners (or in some cases even the FDA)?
Perhaps less straight-forward but also a question of personal perception is: Do more managers (or investigators) get booted from their jobs or experience a loss of confidence in their abilities because they planned for success or planned for failure, no matter the ultimate results of initial trials? The answer is certainly debatable, but your thinking on this may be revealing of the strategy you pick.
The science of proteins and protein production applied to drug discovery, development and manufacturing has advanced over the years. This is both a cause and effect in the proliferation of startups, entrepreneur-scientists in academic settings, and others in this field who rely on outsourcing service providers to progress their programs. In turn, providers have improved their services and technologies—and success probabilities. One provider told us that nowadays, with the appropriate investments, it successfully provides customers high quality material in sufficient supply for clinical trials around 85 percent of the time.
Perhaps, then, the decision to invest more sufficiently upfront to give your program the best chance of success has grown easier to make. With larger companies excited by the prospects of protein-based programs, and data suggesting a sustained comeback in VC funding of biotechnology, here's hoping if you need it, the funding is there to do so.
Editor's Note: Topics such as this regarding development and manufacturing outsourcing strategies, analysis and advice will be discussed in a fully open format at the Outsourced Pharma West Conference and Exhibition, November 10-11 in San Francisco. The conference will provide the opportunity to learn from experts at pharma, biotechs and CRO/CMO. For some informative pre-conference discussion, visit the Outsourced Pharma West Blog.


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Florence Welch + Josh Homme Duet on Johnny Cash's 'Jackson'
A duet between British singer/songwriter Florence Welch (of Florence + the Machine) and desert metal legend Josh Homme (of Kyuss, Queens of the Stone Age, Eagles of Death Metal and Them Crooked Vultures) might not seem like the most likely time to tear a page from the Johnny Cash songbook — but then, the duet partners themselves seem like a pretty unlikely fit.
Of course, that doesn't mean they don't sound great together — or that they weren't able to find their way inside the Cash classic 'Jackson,' about a bored husband and wife who each secretly pine for the bright lights and excitement of the titular big city. Taking the stage for Florence + the Machine's taping of 'MTV Unplugged,' Welch and Homme delivered a suitably smoky performance of the song, then followed it up with a his 'n' hers version of 'Try a Little Tenderness' as made famous by Otis Redding.
You won't be able to see the performances of 'Jackson,' 'Tenderness' (or the rest of Florence + the Machine's set) until MTV airs the episode on Sunday (April 8), but thanks to the magic of the Internet, you can at least hear Welch and Homme's 'Jackson' duet. Have a listen below, and just imagine how great these two would sound if they cut an entire album of old murder ballads.
Listen to Florence Welch and Josh Homme Perform 'Jackson'


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Win a 55″ TV, Surround Sound and Blu Ray with K945, The Sandbar and Warner Bros. Records this Sunday for the BIG GAME!
SUPER Large Games That Are Big are pretty cool! It's like a national holiday in America, whether you like the teams playing or not! Plus, the commercials are pretty cool… and they look even better on 55 inches. Just saying! Join the party with K945 at the Sandbar on this special SUPER Sunday… You know the Sunday we're talking about! Two teams are playing… the 49ers and the Ravens. Yep, that's the one, THIS Sunday, February 3rd! We'll have the game, fantastic food, plenty of adult beverages and your chance to score a SUPER sized 55 inch TV, surround sound and Blu Ray courtesy of Muse, Warner Brothers Records and K945! You can log on to your K945 VIP account to get registered to win or listen to get registered to win. It's that easy! Plus, we'll get even more peeps registered this Sunday at the Sandbar. And YES, you do have to be present at the Sandbar to win. It's MADNESS! Get it? Nevermind… SMH
FYI… Super Large Games That Are Big = a word we can't say legally… Just sayin'!


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Black River Latest Label To Partner With Clear ChannelPrint This Post
Black River Entertainment is the latest label to ink a broadcast and digital revenue-sharing agreement with Clear Channel Entertainment. The deal will include Clear Channel's 850 stations across 150 markets, along with its IHeartRadio digital platform.
"Black River has proven its ability to find, develop and promote an extraordinary set of artists with outstanding musical talent and a genuine passion for country music," said Clear Channel CEO Bob Pittman. "Clear Channel is delighted to work together with Black River artists, helping lead the way to a sustainable digital music industry that benefits everyone – artists, fans, record labels, and broadcasters."
The independent label is home to Craig Morgan, Kellie Pickler, Glen Templeton, and the John King Band. The company is also home to Black River Publishing, Black River Management, and two historic Nashville studios, Sound Stage and Ronnie's Place.
"Every day at Black River, we are focused on finding ways to develop our roster of incredibly talented artists for a long-term career in country music," said Gordon Kerr, CEO, Black River Entertainment. "We are thrilled to enter into this partnership with Clear Channel and to deliver more for our artists while continuing to bring fans music they love."
Clear Channel has also formed similar agreements with Warner Music Group, Big Machine, Dualtone, Glassnote Entertainment Group, Wind-Up Records, and several more in recent months.
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Lynchburg Police at Schools Today Following Newtown Shooting
Lynchburg, VA - Due to Friday's mass shooting in Connecticut, the Lynchburg Police Department has placed an officer at every school Monday.
According to a school district spokesperson, the officers will be on hand for arrival and dismissal. Administrators will also be making rounds at all schools.
Officials say this is just to a way to ease parents' minds and give them a chance to ask questions.


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Queens Park Rangers will have to assess Charlie Austin's shoulder injury, the club's assistant manager Kevin Bond has revealed.
The striker got the opening goal in the 2-1 home win against Bolton Wanderers on Tuesday following several minutes of treatment.
He tried to carry on but eventually had to come off in the second half, and Bond admits that losing Austin would be a big blow to QPR's promotion hopes.
"Charlie's got a problem with his shoulder and we don't yet know the extent of it," Bond told Sky Sports News.
"He had to come off after going on as long as he could. In the end it was too much for him and we'll have to assess it.
"He's as game as they come and got his goal from a great cross by Matt Phillips. We know we're reliant on Charlie and didn't need reminding."
Austin has 14 league goals this season.


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THT Awards
Welcome to the awards.
All stats are for Monday, June 11th through Sunday, June 17th. Please see the week one column for award definitions and explanations.
This week's proof that assigning wins and losses to a pitcher is an arcane practice that must stop
Good luck division
Cole Hamels knows how to win. And by that I mean he won Wednesday's game in Minnesota despite giving up seven runs in six innings on eight hits and two walks. Didn't you know that getting his friends Jim Thome, Hunter Pence, and Carlos Ruiz to smash the Twins pitching staff about the head and neck and dance around the bases is a skill?
Bartolo Colon allowed five runs in five innings on nine hits and three walks, striking out four in Coors Field. Given how Coors has played in recent weeks, that likely isn't as bad a performance as it looks. But that doesn't make it a good performance and Jeremy Guthrie was absolutely gutted by the White Elephants, allowing seven runs in five frames, giving Colon a win despite an ugly line. It also bears mentioning that the two bullpens combined to allow one run in eight innings after the starters hit the showers.
At the same time Matt Cain was posting his 101 game score perfect game, Tom Milone and Josh Outman were throwing baseballs and posting game scores that add up to 54. Outman was in line for the win despite allowing five runs in five innings until Rafael Betancourt gave up three runs and blew the save.
Bruce Chen was hammered for six runs in an inning and two-thirds on seven hits. He failed to strike out any of the 12 Cardinals he faced and gave up home runs to Yadier Molina and Matt Holliday. But he avoided the loss in a wild game that I will talk more about in the holds category.
Bad luck division
Zack Greinke threw seven frames against his former team. He struck out eight, walked none. The only run he gave up was one an Alex Gordon solo home run. But the Brewers offense was stymied by Luis Mendoza and the Royals bullpen and Greinke walked away with a no-decision.
Mike Minor has not had many solid performances this year. Lady luck has not blessed him with exceptional results on balls in play. And he has not pitched well. So it was likely very frustrating to watch Jonny Venters blow the lead that he had inherited from Minor. Minor had allowed only one run to the vaunted Yankee lineup, striking out four, walking one.
Wade Miley and Matt Harrison combined to go 15 innings, giving up only one run on nine hits, striking out 11, walking three. Neither got the win and Miley actually got the loss.
Jake Peavy tossed seven frames with only one run allowed on a Carlos Beltran home run. He struck out six Cardinals and posted a 69 game score, but got the loss as that solo home run was the only run scored in the game.
Hector Noesi gave up only one run, that being a solo home run from Yonder Alonzo in seven innings of work. He struck out five, walked three and yielded five hits. But the Mariners were shut out at home by the Padres and Noesi got the loss.
Ian Kennedy held the Angels to two runs in an eight inning complete game. By my saying that he threw eight innings and was the only pitcher the Diamondbacks used in the game, you know already that he received the loss. Kennedy posted a 68 game score, striking out six, walking none.
Madison Bumgarner held the Mariners to one run in eight innings on three hits and a walk. He struck out four and posted a 75 game score but received a no-decision. His opponent, Felix Hernandez, who I haven't talked about much this season, threw seven frames, allowed one run on six hits, walked one, struck out seven, got a no-decision.
Jose Quintana and Chris Capuano combined for 16 innings, allowed one run on 11 hits between the two of them, walked one, struck out 18. Neither got the win as Addison Reed squandered Quintana's lead.
Vulture Award
Ronald Belisario allowed a run and blew the save only to watch the Dodgers score off Matt Thornton and hand him a win.
Sean Doolittle allowed two runs to blow the save for Oakland. The Oakland lineup then picked him up, scored another pair of runs off Joe Thatcher and Luke Gregerson, giving Doolittle the victory.
Jonathan Broxton blew the lead in the 14th in St Louis. Then in the next half inning, Yuniesky Betancourt launched a two run home run and Broxton successfully defended the lead to ensure that he himself got the win.
Matt Albers got a blown save/win combo in the Sunday night Red Sox/Cubs match.
Wes Littleton Award
Chris Perez recorded his 21st save of the season pitching the ninth inning, protecting a two run lead. The three batters he faced were Casey McGehee, Pedro Alvarez, and Jose Tabata. Now keep in mind that Pittsburgh as a team is averaging only 3.42 runs per game. At the end of the game, the three batters in question possessed season lines of .235/.329/.348, .189/.254/.373, and .230/.291/.340 respectively. And had they defied the odds and put somebody on base, the next two batters up were Rod Barajas (.228/.288/.396) and Josh Harrison (.225/.296/.393). So the chances of digging their way out of even a two run lead with only three outs to play with seem pretty remote. It should surprise nobody that the Pirates were shut out in that game and managed only eight base runners in nine frames.
When Evan Scribner entered the game in the seventh, he inherited a seven run lead. Because of the three inning clause of the save rule, he got his first career save and was then sent back to Sacramento. The Padres have only scored seven or more runs in five games this season in nine or more innings. I'm not sure what would have to happen for them to score seven in three innings.
Please hold the applause
In the Bruce Chen game on Saturday, we had Sam Freeman get a hold for the Cardinals despite allowing two runs in an inning and walking two. We also had Tim Collins get a hold and a loss as the base runner he had left for Greg Holland who scored ended up putting the Royals down to stay. Holland gets the blown save. Collins gets the hold but also gets the loss.
The same day that Collins posts the hold/loss combo for the Royals, Thatcher does the same for the Padres against the A's in the Sean Doolittle game mentioned in the Vulture Award.
Clay Rapada entered the game against the Braves Monday up by three runs with no outs in the ninth. He retired Martin Prado via strikeout and was immediately pulled for lefty Boone Logan. Rapada got the hold despite the lack of any danger given that he was brought in to face one batter with only three outs available to the opponent and a three run lead.
Any sufficiently advanced defense is indistinguishable from pitching
Normally this is the point where I say that all perfect games and no hitters have a healthy dose of luck involved and they do. But when Cain strikes out 14 and only 10 balls are in play outs, I don't have much to talk about. That was truly a masterful performance against an overmatched opponent. I will say that I find it amusing that because the Giants lineup tortured J.A. Happ early and often, Cain's dominance only amounted to a .10 WPA, less than that of either Melky Cabrera or Brandon Belt.
Randy Wolf struck out only one of the 26 Royals he faced. He walked two and allowed six hits, but BABIP good fortune prevailed and Wolf only yielded one run.
Joe Carter Award
Jay Bruce collected seven RBI this week while batting .100/.231/.400. For some perspective, that is the same number of ribbies possessed by Trevor Plouffe, who smacked five home runs and Brandon Belt, who tossed up a 1.400 OPS. In fact, Bruce's .631 OPS was the lowest by a batter with seven RBI by a margin of 405 points.
Also deserving mention here are Alex Rodriguez, Brandon Inge, and Desmond Jennings. That particular threesome each drove in six and ended the week with lines of .182/.250/.364, .231/.286/.462, and .115/.148/.154. Jennings managed to find a way to drive in six runs during a week where he had only four total bases.
Sanchez Award
As offensive numbers have declined in the past few years, it gets harder to bash a player like Ben Revere who this week smacked 10 hits in 30 plate appearances with no walks and no extra base hits. .333/.333/.333 is a better line than it was during the offensive boom of the previous decade and a half. I still submit this note for your consideration though.
On a similar, but inferior scale, Justin Upton went .320/.320/.320 in 25 PA.
Twins shortstop Brian Dozier collected seven hits in 23 PA, which is good. Not as good is the fact that only one of those seven went for extra bases and he took no walks, leading to a .304/.304/.348.
Brian Roberts posted a .318/.304/.318 in 23 PA in his welcome return from concussion.
Roberts' teammate J.J. Hardy went .308/.308/.346.
Kelly Johnson went .292/.292/.292 in 24 PA. That translates to seven singles and nothing else.
Derek Jeter went .290/.290/.355 in 31 PA.
Harmon Killebrew Award
Two sluggers bated .235 this week and still posted very impressive lines. Adam Dunn belted three home runs and walked five times for a nice .235/.409/.765 line in 22 PA. Jose Bautista sent two balls over the fence, chipped in a double, and walked eight times against just one strikeout and ended the week at .235/.480/.647.
Steve Balboni Award
It's actually a minor miracle that Bryan LaHair managed to post a .143/.250/.214 line given that he fanned 10 times in 16 plate appearances. That is not a typo. He really did strike out in almost two thirds of his plate appearances.
Despite a home run and two walks, it seems fair to say that Cody Ransom got dominated by pitchers this week given that he struck out 11 times in 26 PA and closed the week at .125/.192/.250.
Justin Maxwell fanned 10 times in 25 PA, leading to a .222/.263/.444 line.
Giancarlo Stanton, Dan Uggla, Omar Infante, Jed Lowrie, Shin-Soo Choo, Josh Willingham, and Jason Castro are some of the other notable players who struck out at unhealthy rates and subsequently had subpar weeks.
Three true outcomes
Brandon Moss smoked five home runs, walked twice, and struck out 10 times in 25 PA this week for Oakland. I did not see that coming.
Dunn, the patron saint of the TTO, went three-five-eight in 22 PA.
Lowrie posted a one-three-eight in 23 PA.
Austin Jackson went one-seven-eight in 29 PA.
Curtis Granderson: three-five-seven in 31 PA.
The anti-TTO
Norichika Aoki went zero-one-zero for the Brewers in 31 PA, though he did have two of the secret fourth true outcome, HBP.
If you are a stickler about such things, Ichiro Suzuki went zero-zero-one in 27 PA.
Ben Revere went zero-zero-two in 30 PA.
This week's MVP
AL: You know it has been a weird week in the AL when you are contemplating Plouffe and Moss. Trevor Plouffe and Brandon Moss? Yes. Plouffe rapped out three singles, a double, and five home runs. He walked five times and posted a .391/.500/1.087. Moss was the headliner in TTO. All eight of his hits were extra base hits. He walked twice, and ended at .348/.400/1.130.
NL: Joey Votto is a more conventional choice. Votto smoked six singles, two doubles, and two home runs. He walked six times, and had a .467/.607/.857 line.
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I just discovered Kraftynook.blogspot.com! Holy cow – there are some wonderful free SVG files over there!
There are many fantastic sets (for personal use only) available to download for free & the blog owner only asks for thanks so be sure to leave her some love in the comment section of the files you download!
The files are hosted on Google Drive and are easy to download.
Here's a little tutorial on how to download these fantastic files!
Each image is it's own file so you can easily select just those that you want. Here's one of my favorite sets – I <3 Star Wars!
Click "CLICK HERE TO DOWNLOAD" below the picture of the set & you'll be taken to Google Drive.
Click on the filename beneath the image to take you to the download page.
Click on the arrow pointing down to download the SVG file.
You can navigate to the other files in the folder by using the arrows on the side.
When you're done, click on the X to return to Google Drive and use the back button to navigate easily back to Kraftynook.com to find new treasures to download!
Just a few of my favorites from Kraftynook:
Have fun & be sure to leave comments on the Krafty Nook blog if you enjoy the files!!
Looking for more free files? Be sure to check out this post!


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Road test: Audi's A5 coupe is elegant, sporty and economical
A couple of years ago, not too long after the current model was introduced, I was extolling the virtues of the A4 Quattro, Audi's premium all-wheel-drive, mid-size sedan.
It struck me then, as it still does, that the A4 was right-sized for a post-toddler family of four in an automotive world that was starting to realize that bigger is not necessarily better.
I also found that the A4's turbocharged four-cylinder engine offers a superb blend of smooth performance and fuel efficiency, and its sophisticated suspension provide an excellent blend of ride and handling.
The only down side was the nearly $40,000 price tag, which is not outrageous for a premium German sedan but admittedly not right-sized for the average family.
Now, let's change the picture a bit. It's 2011 and the kids have cut the cord (physically, if not financially). Mom and dad are mostly empty nesters and seldom have need to transport more than themselves.
Freed from the endless chores of child-rearing and maybe even with a few dollars they can call their own, they are ready to resume a lifestyle they recall, perhaps not quite accurately, as exciting and carefree.
It's time to buy a new car. The wild youth of yore wants something a little less frumpish than the family sedan, something more exciting ,more stylish, more individualistic.
But there's a catch. The tight-fisted exchequer of the estate hates the idea of losing that captivating blend of performance and fuel efficiency, What's the point of owning a fancy car if all you are doing is running back and forth to the gas station?
Of course, like migrant birds the kids will return from time to time and the family will occasionally have to travel together under the same roof.
Not to worry. Once again, and for just a couple of thousand dollars more, Audi might have just the right blend of performance and practicality.
I'm talking about the A5 coupe,
Its elegantly clean lines set it apart from the crowd and its two-door configuration adds a sense of upscale intimacy. This car commands attention, no matter what car it is parked next to. Your friendly restaurant valet might just assign it a spot in the front row.
And, yes, there is actually comfortable room for four, although entrance and egress will be accomplished most easily by the youngest passengers.
Best of all — I'm talking to you, exchequer — the A5 has virtually the same powertrain as the A4. It is equally quick, perhaps even a bit more agile and a tad more stingy in its consumption of fuel.
Initially, Audi thought many U.S. buyers of this premium coupe might prefer a slightly smoother, more powerful V-6 engine, But they apparently were wrong.
The V-6 has been dropped and the only engine offered for 2011 is the familiar turbocharged 2-liter, 211-horsepower, four-cylinder model that will propel driver and passenger to 60 miles an hour in about 6.5 seconds.
It will return an EPA-rated 21 to 31 miles per gallon of premium fuel teamed with a six-speed manual transmission or 21/29 mpg with the six-speed automatic.


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Oh and before I forget, a recipe for you. When I was in college, one of my roommates would always make pasta with olive oil and parmesan. It's such a simple dish but loaded with flavor - almost like a grown up version of the noodles with butter that I'm sure we all ate as children :) I've kept it in the back of my repertoire and when I'm feeling lazy and have parmesan, I'll throw it together. However, it's basically become impossible for me to eat pasta without "healthifying" it. So, I expanded upon this simple dish and came up with the recipe below.....
Parmesan Pasta
1/2 cup brown rice pasta
1/2 cup edamame, shelled
1/2 tbsp olive oil
1 tsp garlic
1/4 tsp red pepper flakes
1/4 cup parmesan cheese
1. Boil brown rice pasta according to package directions - during last minute of cooking, add frozen edamame. Drain.
2. Add olive oil, garlic, red pepper flakes and parmesan. Toss to coat!
|Love these noodles - such a fun shape!


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GRAND RAPIDS, Mich. — Meijer is investing more than $160 million in new store construction and remodeling.
The investment includes the construction of six new Meijer supercenters and major remodel projects for an additional five stores. Michigan, Indiana and Illinois will each welcome two new Meijer supercenters, with remodel projects planned at an additional four Michigan stores and one Meijer location in Illinois.
"We are pleased to continue to invest in the Midwest communities that have supported us for so long," Hank Meijer, co-chairman and co-CEO said. "By keeping prices low and maintaining our focus on customer service, we have been able to continue to grow during a tough economic cycle."
According to the company, each new store will create at least 250 full- and part-time jobs. Meijer has opened 29 new stores since 2007, and remodeled dozens of others. This has resulted in the creation of thousands of jobs and millions of dollars of tax revenue pumped into local communities.
The new Meijer supercenters opening in 2013 include:
Swartz Creek, Mich.
Portage, Ind.
Detroit, Mich.
Danville, Ill.
Evergreen Park, Ill.
Warsaw, Ind.
Meijer 2013 remodel projects include:
Lansing, Mich. (S. Pennsylvania Road)
Taylor, Mich.
Flint, Mich. (Hill Road)
Springfield, Ill.
Grand Rapids, Mich. (Knapp's Corner)
The remodel projects will include a variety of specific enhancements both in and outside the stores, such as lighting, heating, refrigeration, exterior lighting and parking lot maintenance. Additionally, the introduction of newer technology in key areas during the remodel process will result in reduced energy usage and more energy-efficient stores.
Two of the stores will go through a significantly more comprehensive remodel program. The South Pennsylvania Road Meijer in Lansing will be totally rebuilt, within a 14-month timeframe that will transform the aging site into an all-new store. The Knapp's Corner Meijer will be the first to benefit from a new Meijer flagship remodel that will test design elements which may be considered for future stores.
"We will continue our process of slow, steady growth," Meijer said. "This has allowed us to focus on our customers and team members, while supporting the communities where they work and live."


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COLORADO – Metallic Tie Choker
In stock
Military Green Tie with a golden horn charm
Lengh: 29cm – Adjustable with an extension chain
Read our advice section to take care of your choker.
Registered Design – Reproduction is prohibited
Additional Information
|0.02 g
Our Metallic Tie are printed with metallic and solid inks. As pretty and practical they are, they are delicate products.
With time and extended use, the print can crumble and disappear.
To maximize their resistance and prevent them from being damaged too quickly, we invite you to follow these tips:
- For your first use, start using them as a bracelet. This gently relax the elastic fiber.
- When you want to wear them as hair ties, do not extend it too strongly, this may damage the pattern.
Once in the hair, position it so that the pattern is visible and do not undergo torsion.
Care Tips :
- Avoid wet them too often
- Always dry flat to ensure their elasticity.