text:
NEW YORK (TheStreet) -- Markets turned sharply lower on Friday on concerns of a slowdown in the global economy.
Caught in the headwinds, these four Brazil-based stocks suffered share losses over the session. By late afternoon, steel companies Companhia Siderurgica Nacional (SID) and Vale SA (VALE) had dropped 4.5% to $4.85 and 1.5% to $12.95, respectively.
Oil and gas miner Petroleo Brasileiro Petrobras SA (PBR), commonly referred to as Petrobras, unloaded 3.3% to $11.77, while Sao Paulo-based brewer Ambev SA (ABEV) sank 3.1% to $6.78.SID data by YCharts
TheStreet Ratings team rates COMPANHIA SIDERURGICA NACION as a Hold with a ratings score of C. The team has this to say about their recommendation:
"We rate COMPANHIA SIDERURGICA NACION (SID) a HOLD. The primary factors that have impacted our rating are mixed -- some indicating strength, some showing weaknesses, with little evidence to justify the expectation of either a positive or negative performance for this stock relative to most other stocks. The company's strengths can be seen in multiple areas, such as its revenue growth, notable return on equity and compelling growth in net income. However, as a counter to these strengths, we also find weaknesses including weak operating cash flow, a generally disappointing performance in the stock itself and generally higher debt management risk."
Highlights from the analysis by TheStreet Ratings Team goes as follows:
- SID's revenue growth has slightly outpaced the industry average of 3.9%. Since the same quarter one year prior, revenues rose by 13.6%. This growth in revenue appears to have trickled down to the company's bottom line, improving the earnings per share.
- The company's current return on equity greatly increased when compared to its ROE from the same quarter one year prior. This is a signal of significant strength within the corporation. In comparison to the other companies in the Metals & Mining industry and the overall market, COMPANHIA SIDERURGICA NACION's return on equity significantly exceeds that of the industry average and is above that of the S&P 500.
- COMPANHIA SIDERURGICA NACION reported significant earnings per share improvement in the most recent quarter compared to the same quarter a year ago. This company has reported somewhat volatile earnings recently. But, we feel it is poised for EPS growth in the coming year. During the past fiscal year, COMPANHIA SIDERURGICA NACION swung to a loss, reporting -$0.14 versus $1.36 in the prior year. This year, the market expects an improvement in earnings ($0.93 versus -$0.14).
- The debt-to-equity ratio is very high at 3.67 and currently higher than the industry average, implying increased risk associated with the management of debt levels within the company. Regardless of the company's weak debt-to-equity ratio, SID has managed to keep a strong quick ratio of 2.09, which demonstrates the ability to cover short-term cash needs.
- Net operating cash flow has decreased to $272.23 million or 32.78% when compared to the same quarter last year. In addition, when comparing the cash generation rate to the industry average, the firm's growth is significantly lower.
- You can view the full analysis from the report here: SID Ratings Report


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New Delhi: Some Indian Institutes of Technology (IITs) are experiencing qualms about the new-format Joint Entrance Examination (JEE) for students seeking admission to the elite engineering schools.
Contrary to the hard-sell that the new, two-stage format being introduced this year will make life easier for the IITs and their aspiring students, it could prove to be a cumbersome exercise and a logistical headache, said the administrators of three of the older IITs.
The format works this way: the first part of the joint entrance examination known as JEE-Main is open to all students and their performance in the test will be key for admission to all centrally-funded technical colleges like the National Institutes of Technology, but not to the IITs.
The 150,000 top rankers in the JEE (Main), conducted between 7 April and 25 April, will qualify for appearing in the next stage, called JEE-Advanced, for admission to the IITs and the Indian School of Mines, Dhanbad. These 150,000 candidates also need to finish among the top 20 percentile of students in their school board examinations.
Some IIT administrators are concerned about the possibility of students from a particular state or a few states cornering a majority of the 150,000 top spots in the JEE-Main to qualify for appearing in the JEE-Advanced. That may hinder the smooth conduct of the second stage of the exam in that state or region, given that the preparations for the exam are on an all-India basis.
"The IIT-Main exam results will come out in the first week of May and the registration for JEE-Advanced will start from May 8. Technically you will have little time for arranging new exam centres and other related logistical supports (in the event of the above scenario). This could create a problem," said a senior administrator at an IIT.
For example, if Bihar and Tamil Nadu students form a sizeable portion of the top rankers, then IITs may have to redraw the exam plan. Right now, the IITs have arranged just two centres for Tamil Nadu and four for Bihar.
"What has happened because of the two-tier exam system is that it has become cumbersome. Earlier, we knew how many students are there from a state and prepare accordingly but the new system has taken away that advantage. You have to plan and execute everything from registration to delivery within a period of three weeks," said a professor at IIT-Kharagpur, requesting anonymity.
The professor said that not just arranging extra exam centres, but moving staff and securing question papers at fresh test centres could prove to be a challenge.
"IITs have a tradition of offering fool-proof entrance (tests), but that needs robust preparation. Under this new system, it may prove to be a challenge this time," he said.
IIT-Delhi, which is coordinating the conduct of JEE-Advanced, shares some of the concerns.
"It's a challenge. Students from which state will perform better is unknown and may throw a surprise," said R.K.Shevgaonkar, director of IIT-Delhi. "We will soon sound out to potential exam centres besides those which we have finalized so far."
What's more, the requirement that those appearing in JEE-Advanced must finish in the top 20 percentile of their school board exams doesn't necessarily inspire confidence that IITs will get a better crop of students this year, one professor said.
For example, students scoring at least 58% and above in their class 12 board exam in West Bengal and 64% in Bihar fall in the top 20 percentile while in Andhra Pradesh, a student scoring a minimum of 87% belongs to the category. For Central Board of Secondary Education (CBSE) students, the comparative score is 78%.
The new format may not reduce the burden for students either.
"The number of entrances is still two. Students have to register twice, sit for the exam twice. So, where is the question of (it becoming) less burdensome for students? Internally we knew that this system may not be (the) best," said a professor from IIT-Bombay, who declined to be named.
The format of the IIT-JEE, one of the toughest examinations in the country with just two of every 100 candidates qualifying for admission to the institutes, was tweaked after complaints over the falling standards of IIT students.
IIT aspirants are upset over the top 20 percentile requirements.
"I fail to understand how a student's scoring 79% is less talented than somebody scoring 80% and getting qualified to sit for the JEE-Advanced. This is little unfair for many students who are sitting on the fence of that 20 percentile yardstick," said Dipak K., an IIT aspirant from Delhi.

subset: commoncrawl


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The Visit
Brock and his parents flew to Nevada, then made a two-hour drive to Cedar City, Utah. There, they checked into their hotel before Brock was treated to a nice dinner at a local steakhouse.
Brock met several coaches and team members and bounced questions off them about the program and specifically the kicking situation. After dinner, they went back to one of the player's dorms and played video games, shooting the breeze and talking about Southern Utah football.
The next day, Brock took an official tour of the campus, learning about the history of the school and the academic opportunities he would have. Before they left to go back to California, a Southern Utah coach pulled Brock aside and offered him a scholarship.
Brock didn't commit right away, but he liked Southern Utah a lot. He had a leader with signing day approaching fast.
Decision Time
Whatever Brock Miller eventually decides, it will be the end of an exhausting process that will have countless rewards.
Brock Miller
For one, he will play college football--something a lot of kids dream of. All the different steps of the recruiting process, including the final decision, brought the Miller family closer together. And Brock learned a valuable lesson early on that will make him a success in life: there is no substitute for effort.
High school football is finished, but Miller still trains every day, working on his kicking, his strength and his flexibility. His dad set up a big net in the back yard for Brock to kick into. After Brock killed the grass, Doug installed a patch of artificial turf for Brock to practice kicking on.
Brock Miller is just a face in the recruiting crowd, quick to say that he's hardly the best prospect out there. But future recruits can learn something from Brock's approach.
After all, it worked.
"Work hard every day," Brock said, "because that way you know that at the end of the day, I put in 100 percent, so when the next step comes around I'm going to be ready for it."
UPDATE: As thousands of high school players made their intentions official on signing day, so too did Brock Miller. He picked Southern Utah and will join the Thunderbirds for the 2009 season.
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The undefeated Denver Broncos are averaging 42.3 points per game which is 10 more than the second-place Green Bay Packers. The team is led by 37-year-old quarterback Peyton Manning who is two years removed from season-ending neck surgery. Benjamin Hochman of the Denver Post joined Bill Littlefield to discuss Manning's potentially record-breaking season and the Broncos.
BL: Benjamin, is it safe to say that Peyton Manning's neck is just fine?
BH: I would make that argument. There is no question about it. Watching Peyton Manning is like watching a college kid playing Madden or some video game and just dominating the opposition. It's stupid and stupendous.
BL: After the Bronco's 37-21 win over the Raiders on Monday night Manning said, "That was a couple of self-inflicted wounds. We had to settle for field goals. We had pretty good field position to have a turn over there that's something we gotta correct." Listening to Manning you would think the Broncos had just lost that game. Was he really that upset about the team's performance?
BH: Now we've seen Peyton Manning on Saturday Night Live. We know he can do a little acting. One could wonder if he's putting on this persona of someone who must be a perfectionist. Or we look at it the other way, this guy's just a mad scientist and needs perfection. He cooks things up and wants it to be perfect. If there's a play with a team up 30 late in the game and some guy takes the wrong step he's gonna let that guy know about it. Yes, the Broncos are doing very well so far. 3-0 ain't bad. But at the end of the day all that matters is the playoffs. One radio host in Denver said that the Broncos are playing 20 preseason games. Nothing matters until the playoffs. But if you ask Peyton, what he's trying to do is set the tone so that when they get in the playoffs they'll be unstoppable.
BL: Well. one thing might matter during the regular season. Peyton Manning is on pace to set some records. What records are those?
BH: My goodness. You could argue — I mean he's numerically on pace to set records for touchdowns and passing yards, and maybe more exciting for the coaches is the fact that he has yet to throw an interception yet. The fact is Peyton Manning is playing better than Peyton Manning has ever played.
BL: Last season, Peyton Manning's first in Denver, he had a solid showing certainly but nothing quite like this. What has changed?
BH: Well, a lot of the receivers have been saying that he has more zip on his ball heading into this year. Then, of course, there is the emergence of two players. One being Julius Thomas, who fantasy owners now know, the tight end who has emerged and scored a touchdown in every game. He hadn't played in previous years. And then the acquisition of Wes Welker. Welker might be most famous for being the player that Giselle was screaming about because Welker dropped passes in the Super Bowl a couple years back, but Wes Welker — the little guy — is one of the most reliable receivers Peyton Manning has, and he's caught a touchdown in every game as well.
BL: You have suggested that Manning might be the most dominant 37-year-old of all time. That would be a small sample though, right?
BH: That's true. That's true. You look at some seasons Brett Favre had, I mean they weren't bad, but a wild card I could throw out there is Warren Spahn the old Braves pitcher. A lot of people don't remember Warren Spahn, but when he was 37 he led the National League in wins, in innings pitched, complete games, and for you current sports fans, in WAR and WHIP.
BL: Will Manning and the Broncos offense continue to be this spectacular through the rest of the season? It's a little hard to think that anybody would.BH: I mean, that's the thing. We saw Tom Brady and Wes Welker go undefeated in the regular season a few years back and that was extraordinary. I would wonder if maybe a team like the Kansas City Chiefs — an up-and-coming team in the [AFC West] division, understanding the importance of playing Peyton Manning and the Broncos and with new coach Andy Reid looking to make a mark in the division — if maybe that's the team that defeats Denver. I mean, there are four guys catching the ball and you could ask 10 different people and they would say different guys [are] the best receiver they have. I mean, it's a great problem to have and by the way, the guy throwing the ball is one of the most accurate guys in NFL history.


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Download the ICS Branding Pack
15 September 2017
14 September 2017
13 September 2017
12 September 2017
11 September 2017
07 September 2017
30th November - 1st December 2012
The ICS in conjunction with the Philippine Urological Association will be hosting a three hour afternoon Urodynamics workshop and a half day morning coursein Manila. The course will take place between Friday 30th November-Saturday 1st December 2012 and will be held at the Dusit Thani Manila Hotel.
The local coordinators are Dr. Joel Patrick A. Aldana and Dr.Marie Carmela M. Lapitan.
The ICS speakers for this event are Margaret Sherburn, Vincent Tse and Patrick Woodman.
The topics that they will be presenting are below:
Vincent Tse;
• Basic Urodynamics Workshop
• Overview and management of Refractory OAB
Margaret Sherburn;**
• Current Conservative Treatment for Female SUI
• What is the evidence for rehabilitation in POP
Patrick Woodman;
• Current Recommendations on Diagnostics for SUI and occult SUI
• Current Surgical & Minimally Invasive Treatment for Female Urinary Incontinence
• Complications of SUI Surgery: Recognition and Management
• ICS Classification and evaluation of Pelvic Organ Prolapse
• Role of the mesh in POP surgery
• POP Repair: vaginal vs. abdominal approach
For more information please see the below link entitled Course Information for a copy of the event programme.
For more information please contact Dr. Marie Carmela M. Lapitan; email@example.com Dr.Eliza M. Raymundo; email@example.comfirstname.lastname@example.com
Alternatively please contact the Jenny at the ICS office; firstname.lastname@example.com


text:
Diwali Card, Mantra, SMS, WP
by: ITINDIA • 6
All Android applications categories
by: ITINDIA • 6
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Get involved in the festive season with amazing and lovely wallpapers and mantras for all the five days of the festival with this app. Wish all your friends and relatives by sending cards and sms from this cool app.
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text:
The Santa Barbara City Council is set to get an update tomorrow on a new hospital helipad in the city which is helping to save lives, but isn't making some of its neighbors very happy.
As part of a massive rebuilding project, Cottage Hospital added a helipad, which allows critically injured, or ill people to be flow to the facility in circumstance when minutes could make a big difference.
The helipad has been much busier than expected with dozens of flights since opening February 5th.
During its first week alone, there were 13 flights, including five between 10 p.m., and 5 a.m., leaving some neighbors upset over noise.
Hospital officials have been meeting with area residents about the concern, and say they've talked to helicopter operators about issues like flights paths, to try to minimize the disturbance.
The hospital is scheduled to update the Santa Barbara City Council on the situation when the council meets at 2 p.m. tomorrow.


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|Comments on Photo
|Add Comment
By Eric Wiessinger
Oct 24, 2012
Assuming I'm doing this per the OP this definitely goes. I've done it from a stand-start but the couple of variations on the sit-start are hard and/or sharp. I've attached a photo with some markup showing the stand-start holds I used. Pretty cool compression moves in the middle!
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text:
Powells Point (GNIS FID: 992775) is a populated place located within the Township of Poplar Branch, a minor civil division (MCD) of Currituck County.
The elevation of Powells Point is 10 feet. Powells Point appears on the Jarvisburg U.S. Geological Survey Map. Currituck County is in the Eastern Time Zone (UTC -5 hours).
Currituck County: Subdivisions (MCDs) | Cities & Towns | ZIP Codes | Features (airports, churches, hospitals, etc.)
BIG Map |
Driving Directions |
Data Source - USGS GNIS FID: 992775
BOUNDARY MAPS: Township of Poplar Branch | Currituck County
Duck, NC
(5.8 miles E)
Southern Shores, NC (7.2 miles E)
Kitty Hawk, NC (10.7 miles SE)
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(13.5 miles SE)
Coinjock, NC (13.9 miles NNW)
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text:
In an exclusive interview with Maddog Rock Radio, GREAT WHITE frontman Jack Russell was asked if there is a chance of the band releasing any new music in the near future. "Absolutely!" he replied. "[Guitarist] Mark [Kendall] and I have been talking about doing another record and getting the original members back together to do a new album and also a DVD from a live show. I think that'd be a lot of fun and I've talked to a few of the guys already and everyone seems into it so we'll see what happens."With regards to whether he is planning any more solo albums, Russell said, "Yes, I am. That's where my heart and soul is at this point. Don't get me wrong because I love GREAT WHITE but there are other things inside of me that needs to come out. It's nice to be able to do both things and to have the inspiration to do both. There are certain things I can't say with GREAT WHITE that I can say in my solo work." Read the rest of the interview here.
JACK RUSSELL: Original GREAT WHITE Lineup To Reunite For Album, DVD
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text:
First we showed you absurd baby products.
Then we topped it off with bizarre mom products that — shockingly — may have been worse.
And now we're moving on to the most ridiculous potty training products to assist in the diapers-to-toilet transition. Parents today are using more than just training potties and Everybody Poops:
1. Tinkle Tubes
Yes, the Tinkle Tubes can be used as an "emergency potty," but it's also used as a "penis extender" for little boys to stand and pee. Even better? Parents no longer have to touch their son's "little soldier" when helping them urinate. Yes, they said "little soldier." ($5.99 at Baby Rock Apparel)
2. Potty Mitts
Wait! You forgot your plastic germ shields! And to think we all survived on soap and water alone. ($3.99 for a 20-pack)
3. My Pee Pee Bottle
For something that's designed to hold urine, they sure make it look like something designed to hold juice.
4. Poteez: The Disposable Potty
Protect your outdoorsy child from the dangers of trees and grass. Instead, have your kids poop in a cardboard box that you'll then immediately throw in the trash — or leave on the side of the road. Because, really, are you putting a poop-filled cardboard box in your trunk?
5. Peter Potty Urinal
I'm sorry, but if you're big enough to pee into a stand-up urinal then you're big enough to use the big boy potty. I don't need another plastic contraption to clean out. ($39.99)
6. Toilet Buddies
I refuse to believe I have to put hideous stickers all over my toilet in order to get a toddler to potty train — especially when the characters have names like CaCa Cow and Poo P. Bunny. Toilet Buddies even makes ridiculous toilet music.
7. Piddlers Toilet Targets
You could spend $6 on 30 of these toilet targets — or you could spend $4 for a few thousand Cheerios or Fruit Loops targets. Up to you.
[main image: Potty Training Power]
Also check out:


text:
Minnesota's planting season is downright optimistic
Below-average rainfall from August through December last year, and not much snow so far this year, has some farmers and gardeners worried about drought. Don't worry, says Thomas Hoverstad, a scientist with the University of Minnesota's Southern Research and Outreach Center in Waseca. Hoverstad spoke with Edie Schmierbach of the Mankato Free Press and said that the lack of moisture and snow cover means farmers won't have to wait as long to get into their fields to plant this spring. "This situation is not bad news," he said. Minnesota is usually wet in the spring, Hoverstad said, with fall rains used to recharge the soil's moisture level. "We didn't get that last fall, but hopefully in March and April we can replace that," he said. Roger Engelson of Green Thumb Garden Center in Mankato said warm temperatures caused lilacs to bud early and then freeze. If you avoid pruning them, they may come back for 2013, he said. Flower beds will have spotty shows of crocuses and daffodils, but they should come back next year as well, he said.
To avoid inevitable legislative budget cuts, the Sleepy Eye school board approved a plan for a four-day school week and will send the plan to the state Department of Education for approval, writes Fritz Busch of the New Ulm Journal. The schedule will begin next school year. Board member Ron Geiger said the four-day week transition avoids making further cuts. A committee found adopting a four-day week would save the district more than $80,000 a year, It will add 2,748 instructional minutes and 370 staff working minutes a year by adding an hour and 20 minutes to each school day and closing buildings on Mondays. Eight-period school days next fall would begin at 7:55 a.m. and end at 4 p.m. This year, school days start at 8:15 a.m. and end at 3:01 p.m.
Hospitality Minnesota President Dan McElroy told the New Ulm Chamber of Commerce last week that state hospitality and tourism is still struggling to regain its pre-Great Recession levels, writes John Moniz of the New Ulm Journal. McElroy said 2012 was the first year many of the subtypes in the industries returned to normal levels. He said the rest will also return in the next couple of years if the economic recovery continues. He offered some stats: The tourism and hospitality industries employed an average of 235,000 people in 2010; almost all revenues are spent locally or subject to local sale tax; tourism is the second biggest private employer after manufacturing and, in 2010, accounted for $11.3 billion in total sales, or 5 percent of the gross state product, along with $4 billion in wages and $732 million in sales tax revenues, or 17 percent of the total state sale tax; there are almost 10,000 restaurants, 870 hotels, 850 resorts and nearly 500 campgrounds. McElroy attributed to the large number of hospitality and tourism businesses to the sheer size of Minnesota and the wide diversity in both its outdoor terrain and city attractions, like the Mall of America in Bloomington and the Mayo Clinic in Rochester. He also said the newest tourism draws have been outdoor activities, including bird watching, bicycling and cross-country skiing.
Speaking of tourism, Peter Passi of the Duluth News Tribune writes that Duluth's hospitality industry thrived in 2011. Last year, the city received nearly $8.2 million in local tourism taxes collected by hotels, motels, restaurants and bars. Tourism tax revenue rose more than $400,000 from 2010, climbing 5.3 percent. "I think it really points to some of the economic recovery we're seeing that's better and faster than we anticipated," said Dave Montgomery, chief administrative officer for the city of Duluth. "Duluth is attracting people, and they're feeling more comfortable about staying in hotels and going out to restaurants." The city has $748,800 more than what it had forecast for tax collections in 2011. Some will go to pay off more than $129,000 in overdue utility bills at the Great Lakes Aquarium, but most will go into a reserve fund to use for capital improvements to local tourist attractions, to cover unanticipated costs and possibly to pay for new projects.
Sajid and Amanda Ghauri of Moorhead have spent their 20 years of marriage reveling in their multicultural life together, writes Roxane B. Salonen of the Fargo Forum. Sajid was from Pakistan, a student at Minnesota State University Moorhead. Amanda Wray was a local girl. He first saw her in the library and "it was love at first sight," he said. She later fell for him during the Heritage Dancers campus folk-dancing group he joined to be near her. During their courtship, some questioned Sajid's intentions, concerned he might be after a green card. But "every time I came back and was face to face with Sajid, we just connected on so many levels; on a human level but also on a spiritual level. And when you feel something is right, you have that strength to follow through," Amanda said.
They celebrated a two-culture wedding where the bridesmaids wore saris while the bride wore a traditional Western gown. Now they have four children, ages 15 to 2. Asked what makes for a successful marriage, Sajid concluded: "You have to ignore each other's weaknesses, talk to each other and help each other out. … And if you can, go out of your way and help somebody out. And don't expect anything back."
The old creamery building in Hendricks, vacant for 30 years, is due for a facelift. Jason Markkula, who renovated the Hendricks bank building and turned it into a hunting lodge, plans to rehabilitate the decayed but solid structure and put a microbrewery in it, writes Steve Browne of the Marshall Independent. Markkula said he and his friend started Bank Brewing Company to give back to the community: Part of the profits from two of the company's brands, Walleye Chop and Rooster Lager, go to Pheasants Forever to buy land for wildlife areas. Bank Brewing brands are currently brewed in Cold Spring and Lucan. Now Markkula wants the company to have its own brewery. "We've always talked about how the creamery building would be a great place to have a brewery. It's such a visible landmark in Hendricks and it deserves to be restored," Markkula said.
Vince Robinson, enterprise facilitator of the Lincoln County Enterprise Development Corporation, said there are currently two grant applications to rehabilitate the structure. One is a redevelopment grant from the Minnesota Department of Employment and Economic Development for $57,000. The second is from the federal Small Cities Development Program to be used for projects around Hendricks, of which $40,000 would be used to update doors, windows and insulation in the creamery. Hendricks City Administrator David Blees said the brewery should generate three to five new jobs right away and possibly more after the first year it's operational. "Hopefully we'll be brewing in the creamery in 2014," Markkula said.
The Moorhead City Council rejected a petition to repeal a paraphernalia ban, writes Wendy Reuer of the Fargo Forum. City Clerk Jill Wenger said 1,797 of the 2,915 submitted signatures were found invalid when names were not legible, the person was not a Moorhead resident or not registered to vote. Discontent owner Tom Tepley, who helped organize the petition with other smoke shop owners and employees, said "we registered over 1,100 people. There was no doubt in my mind it was going to get thrown out. It didn't surprise me." The petition seeks to repeal the paraphernalia ban passed in November which makes selling or possessing any item law enforcement deems drug paraphernalia a misdemeanor. The ordinance is stricter than state law, under which an item must be proved to have been used for drug use. The petition review process took six days for Wenger, five city staff members and eight Moorhead police volunteers.
City Manager Michael Redlinger said volunteers were necessary because the cost of using staff time for certification would have been "astronomical." Tepley said using police department volunteers tainted the process. The petition needs at least 1,847 signatures to move forward. Tepley closed his Moorhead shop Jan. 11 after the ordinance took effect. He said he may open again and circulate the petition in his stores.
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$ saved by Sleepy Eye
Although the Sleepy Eye school district may save $80,000 (which seems pretty minimal), I would imagine that parents will more than pay for that with child care and kids will pay for it with longer days and longer breaks between lessons.
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text: Neil Brock Posted October 6, 2011 General Questions: First things first, where can I download the FM 2012 Demo? The demo this year is only available to download and play via the Steam platform. If you don't already have Steam, you can download and install it from here: http://store.steampowered.com/about/?snr=1_4_4__11 If you already have Steam, the demo can be found here: http://store.steampowered.com/app/901788 A general FAQ in regards to Football Manager and why the game is on Steam this year can be found here: http://community.sigames.com/showthread.php/275972-Football-Manager-2012-Activation-Steam-FAQ How do I install the FM 2012 Demo? You can download and install the game by clicking here: http://store.steampowered.com/71280/ - Click the green 'Install Demo' button for the Football Manager 2012 Demo - You should now be informed of the game size and estimated download time, make sure you have enough space on your hard-drive to install the game - Click the 'Next' button - Choose whether you want a start menu shortcut and/or a create desktop shortcut, then click 'Next' - The demo should now begin downloading; you can track the process of the download by looking at the blue process bar at the bottom of Steam - Click 'Finish' - If you click in the 'Library' section, the demo should be highlighted in yellow showing you how much of the download has been completed and the current download speed - When the game finishes downloading there will be a pop-up in the bottom right hand corner of Steam telling you it's completed - Go to your Library, right click on the Football Manager 2012 Demo and click 'Play Game' - The game will perform the first time set-up and when complete will launch the game I've gone to start up my game via the Football Manager 2012 Start Screen, but 'Start New Game' is greyed out – why is this? Included in the demo are the Quick Starts only, so to start the game click the Quick Start and choose the league which you wish to play. Bear in mind the available leagues will depend on what region demo you have downloaded. What are the minimum specs for running the Football Manager 2012 demo on my system? PC OS - Windows XP/Vista/Windows7 Processor - XP - 1.4ghz or faster Vista/W7 - 2.0hgz or faster Memory - XP-512MB Ram, Vista/W7 - 1GB Ram Video Card - 128MB minimum. Supported Chipsets – Nvidia FX5900 Ultra or greater; ATI Radeon 9800 or greater; Intel 82915G/82910GL or greater Earlier cards may only display 2D Match Viewer Mode and are not supported. Laptop versions of these chipsets may work but are not supported. Mac OS – OS X 10.5.8/10.6.x or higher Processor – Intel Processor Video Card – 128MB Nvidia GeForce 7300 GT or greater, ATI Radeon X1600 or greater Please note, if you system doesn't meet the requirements, the game may work, but we/SEGA do not offer support on these machines. We suggest people who aren't certain if it'll work do indeed try the demo first before buying the game. What leagues can I run via the Demo? In the demo you can only run 'quick start' games, which only run one league and a small database. The demo includes the following: Australia, Belgium, Denmark, England, France, Italy, Netherlands, Norway, Scotland, Spain and Sweden. Will I be able to download the Demo no matter where I am? I'm afraid users in Germany, China, Hong Kong, North Korea and South Korea will not be able to download the Demo. 0 Share this post Link to post Share on other sites


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text:
32 thoughts on "January 21, 2013"
It's cheaper to pay dolts to count your stuff than it is to pay your own employees, because they can't be trusted in the first place. Dolts, of course, are "professional."
Perhaps they are at least bonded?
I was bonded by my company, because I was driving the vehicles, and counting in pharmacies., but most of the people I worked with couldn't get bonded by a dominatrix with superglue.
Lol, that last bit made me laugh! We sell a variety of higher quality "Super Glues" that have differwent viscosities and cure/drying times and I always warn customers who aren't familiar with such glues that no matter which you chose, the work the fastest on flesh……udually to what ever you're trying to repair or assemble!
Well off the 'bonded' subject but the faster the super glue cures, the higher the apparent heat generated. Nasty little skin burns…
JoeX, I snarfed my coffee. Ow…
But, you're right – I used to work with similiar characters. I was much happier hiding on the stock shelves. Yes, that's right ON – all the way at the top.
LOLOLOL!!! And I know a couple of Dommes who would just love to glue something… er, did I say that out loud?
I don't know if they are bonded. The picture doesn't show the legs of the chaingang.
Although the orange does remind me of Guantanamo Bay jumpsuits.
I've seen people commited to "community service" sentences dressed the same way for picking up litter and such!
It was more expensive for my store.
The inventory guys fudged up our inventory big-time. So the management was forced to give us drones extra shifts to make up for their mistakes.
That, Kiwi, I can fully believe! They did it to one of the stores I used to work. They did it two years in a row before they caught on that it wasn't such a good idea. Now they use their own employees and close the store for one day.
I wanna see what kind of positive spin Lana can put on this one. Although, her coming-to-accept-reality would be a GREAT storyline to have. Some things just don't have positives, and a sketchy, unreliable inventory crew is one of them. Corporate CEOs giving themselves bonuses so they can cut payroll is another. Dungeon Masters that have no clue what goes on at the store level is another. A lot of these have a lot to do with retail, don't they?
Based on her question alone I think she may have finally realized that there isn't much to be positive about when it comes to Grumbels…
I think Lana sees reality, but she's able to spin it deliberately.
It's a skill, not a delusion.
Ahhh REGIS, so glad I don't have to deal with them anymore.
Who is REGIS?
Is that your final answer?
I thought Regis was the hair salon place.
I thought Retail and Grocery Inventory Specialists Inventory Service (RGIS) was a soul-sucking job.
Apparently, I'm mistaken.
@Golden Toad You are correct about that being a soul-sucking job. I loathe to say this but I would take a day in retail over ever working with hem again.
It's actually RGIS who has always done our inventory, I have just always called them REGIS so I have a name to blame.
Hey, they're professional counters… they learned by watching Sesame Street…
OK, I'll bite: What is EGRGIS and acronym for?
Can't remember if they ever revealed the acronym, but if you say it out loud, it's "egregious"!
as in "an egregious waste of time and money"…
I know a couple of people that did the REGIS route. Uncompensated driving (you get to deduct the gas and mileage for taxes, but that's little compensation in June or December), flex hours, supervisors on call 24/7, screwed up sleep schedule, and massive turnover. Something something getting exactly what you pay for.
On the one hand, the orange uniforms are kinda funny. When I worked for the Retail and Grocery Inventory Specialists Inventory Service (RGIS), we sometimes joked how the place felt like "Hotel California" ("You can check out any time you like | But you can never leave").
On the other, I have never seen uniforms that look like "prison" uniforms.
At RGIS (http://www.rgis.com/us_en/), we wore maroon and grey polo shirts and non-jeans trousers (black prefered/required depending on team). Mostly maroon for regulars, mostly grey for team leads (like me). Washington Inventory Services International (WIS / WISI) (http://w3.wisintl.com/), wore blue polos. I've never met someone from American Inventory. And yes, there are tons of other companies that do inventories (http://www.isninv.com/).
I do know that some of my coworkers are ex-cons, and one who wasn't but was "banned for life" for stealing from one of the clients we routinely counted. I do know that many inventory personnel look uncouth. But until you talk with or witness a crime by one, you never know if that human being is "good" or "bad". The last season that I worked for RGIS, first time in years that someone from my district was caught stealing was someone who had been with us off and on for years, and had no record of a crime. The individual had stolen a boxless item from a case (and no store associate around due to cutting hours) with the claim of waiting to ask someone about it and "forgotten". Considering that person was approached by the client's internal audit manager during lunch break while eating an unpaid-for meal from the client's deli-case, it is likely a pattern of behavior.
-former inventory zombie
I wonder hope much stock "disappears" when stores use such companies to do inventory. I have heard more than a few stories on the subject.
Gotta love inventory services. I'll never forgot the night one of their drones pocketed a pair of sunglasses, but was too stupid to cut off the security tag on the way out. I was more concerned about the counts he had already completed than the $8 sunglasses he attempted to pilfer. What really got me was that his supervisor tried to make excuses before I kicked his butt out the door!
For the past few weeks I've been experiencing problems with the comic image only loading partway and then disappearing. Some days it's worse than others. It's only been happening on this site. Anyone else experiencing this? Are you working on getting the problem resolved, Norm?
What browser are you running? I am running FireFox. I had problems with IE doing that on some sites thats why I went to FireFox. I have no problems with FireFox loading this page.
I've been having the same problem, and yep, it's IE. Sadly, I read from my work computer, which I don't have the authority to upgrade to Firefox or Chrome.
Regis is a serviced office rental company.
We pay them a slightly larger fee than we would pay to just lease a bare office & they take care of electricity, aircon, break-room supplies, reception, phones … Probably saves us half an employee all-up & they have coverage 52 weeks a year, 8 AM to 6:30 PM.


text: I've got a couple LP shirts and they seem to be beautifully made, with a very unique style to the way the placket and collar are cut. Recently, a reputable seller on EBay stated that he was selling a "Loro Piana Made by Borrelli" shirt. Then, a few days ago, I saw another one on EBay with the same claim -- that the LP shirts are made by Borrelli. There is no similarity at all between the cut of the Borrelli shirts I have to the LP shirts. LP is simply unique. Not much hand stitching in LP, as in Borrelli, but the cut is quite interesting to examine. Does anyone know if this claim on EBay holds any water.


text:
Posted by Tim Cranton
Associate General Counsel
Recently I blogged about the successful takedown of the Waledac botnet by the Microsoft Digital Crimes Unit in an action dubbed "Operation b49." Our intention was to disrupt the Waledac botnet for the long term, as well as mark a new phase in our efforts to combat botnets. Today, we've released some of the early findings that we and other researchers have made on the impact of Operation b49. Highlights include greatly reduced communications within the bot network, a drop-off in new infections and some interesting news about post-takedown spam levels.
To review the findings in detail, take a look at our post on the Microsoft Malware Protection Center blog. We're very encouraged by the initial outcomes of this action, but there's much more work yet to be done. Stay tuned.


text:
Section Menu
Haub School Online MBA a "Best Value"
Thursday, March 22, 2012
PHILADELPHIA (March 22, 2012) – Saint Joseph's University's part-time MBA program was recognized as a "Top 25 Best Value Online MBA Program" in a recent ranking.
Business MBA, a national ranking agency, released the "Top 25" ranking on March 21. The Haub School of Business' online MBA ranked No. 11.
"Given the soaring costs of higher education, and an uncertain job market, we believe that it is important to direct students towards MBA programs that offer the best combination of a high quality education and affordability," says James Harrity, president of Business MBA.
Saint Joseph's online MBA is a 53-credit hour AACSB accredited program. Students may transfer up to 20 hours of previously earned credits into the program. Several different concentrations are offered. The cost of the program is$45,898 for 53-credit hours and financial aid is available.
The Haub School introduced the online MBA in 2011 in response to student demand. Stephen Porth, Ph.D. '80, executive director of graduate programs and associate dean, says the flexibility of the program makes the online option a popular one with students. "This format better meets the needs of many in our student population as they juggle work, family life and education," says Porth.
For more information on Saint Joseph's online MBA visit: http://www.sju.edu/academics/hsb/grad/online/mba/index.html
The largest Jesuit undergraduate business school in the country, the Haub School is an international AACSB-accredited institution in business and accounting, offering programs at the bachelor's, master's and executive master's levels. The school was named one of the nation's top business schools in Princeton Review's "The Best 294 Business Schools"; included among Bloomberg BusinessWeek's "Best Undergraduate Business Schools"; ranked No. 12 in the nation for infusing ethics in the curricula by The Aspen Institute; and, for eight consecutive years, has been recognized by Beta Gamma Sigma, the honor society for AACSB with either the Gold, Silver or Bronze Chapter Award.
Media Contact
Carolyn Steigleman, Director of Communications for the Haub School of Business, 610-660-1355, firstname.lastname@example.com


text:
The New Pact for Europe project was launched by the King Baudouin Foundation (Belgium) and the Bertelsmann Stiftung (Germany) and is supported by a large transnational consortium of institutions.
The King Baudouin Foundation (KBF) is an independent, pluralistic foundation working in Belgium and at the European and international level.
The Bertelsmann Stiftung is the largest private operating non-profit foundation in Germany, created in 1977 by Reinhard Mohn. The foundation is active in political, social, economic, educational, cultural and health-related issues.
The BMW Foundation brings together leaders from across communities, cultures and countries to drive Social Innovation, promote Global Dialogue, and encourage Responsible Leadership.
The Calouste Gulbenkian Foundation is a Portuguese private institution of public utility whose statutory aims are in the fields of arts, charity, education and science.
The European Policy Centre (EPC) is an independent, not-for-profit think tank, committed to making European integration work.
The Open Estonia Foundation (OEF) is a non-governmental not-for-profit public benefit foundation established in 1990 with the support of the philanthropist George Soros. The foundation is based in Tallinn, Estonia, and is affiliated with the global Open Society Foundations (OSF) network.
The Open Society Initiative for Europe aims to contribute to more vibrant and legitimate democracies in the European Union by working with a wide range of civil society actors and strengthening less central voices.


text:
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AR-15 rifle
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Cops: Teen Used New AR-15 to Kill 'Dream Girl'
Allen Ivanov had to read the manual just before shootings
- The teenager accused of killing three people at a house party near Seattle bought his AR-15-style rifle so recently he had to study the instruction manual before the rampage, police say. According to court documents, 19-year-old Allen Ivanov has told police that he bought the Ruger firearm just a week...
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Supreme Court: Bans on Assault Weapons Stay
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Car Dealer Offering Free AR-15 Assault Rifles
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AR-15 Inventor's Family: He'd Be 'Sickened' by Mass Shootings
Eugene Stoner's kids, grandkids say he designed the rifle for military use only, not civilians
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How Orlando Shooter's Gun Differs From an AR-15
Shooting renews debate over semiautomatics
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Newtown Families' AR-15 Suit Is Chugging Along—Surprisingly
That's not to say its chances look good
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New York Times
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Lawmaker Is Giving Out Free Assault Rifles
Says death threats won't disrupt his plan
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Supreme Court Rejects Move on Assault Weapons
Justices refuse to hear case against weapons ban
- Acting in the aftermath of the San Bernardino mass shooting, the Supreme Court on Monday rejected an appeal from gun owners who challenged a Chicago suburb's ban on assault weapons. Two conservative justices said they would have heard the case and struck down the ban. The Illinois State Rifle...
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ATF: San Bernardino Rifles Were Legal—at First
Weapons used by San Bernardino shooters altered for more power after purchase
- The weapons used by the San Bernardino shooters may have been legally obtained , but that doesn't mean they remained legal under California law. The two .223-caliber semiautomatic weapons and two 9mm pistols said to have been carried by Syed Rizwan Farook and Tashfeen Malik in Wednesday's attack were...
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Walmart To Stop Selling AR-15s
Retailer claims the decision was financial, not political
- Walmart, which sells more guns and ammunition than any other retailer in the country, will stop stocking AR-15s and other high-capacity firearms known as modern sporting rifles in the coming weeks, Quartz reports. Rumors about the change were circulated yesterday and confirmed to multiple sources today. Interestingly, a Walmart spokesperson...
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DC Cops: Lawmaker's Assault Rifle Not a Problem
Gun laws don't apply to congressman's office
- Critics of conservative GOP Rep. Ken Buck's fondness for guns appear to have shot themselves in the foot. After the congressman tweeted a photo of himself and Rep. Trey Gowdy holding an assault rifle in his office last week, police received complaints that the AR-15 might violate Washington, DC'...
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Zimmerman Search Turned Up Lots of Weapons, Ammo
He ditches public defender for private lawyer
- Cops found a hefty cache of weapons and ammo at the home George Zimmerman shared with his girlfriend after his arrest on domestic violence charges last week, CNN reports. A search turned up three handguns, a 12-gauge shotgun, an AR-15 rifle, and 106 rounds of ammunition, according to court documents...
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Assault Rifle Stolen From Congresswoman's Home
Weapon was unsecured in pro-gun lawmaker's garage
- Pro-gun lawmaker Rep. Renee Ellmers might need to introduce some tough new gun control measures in her own home: An AR-15 rifle was stolen from the congresswoman's home last week after it was left leaning against a gun locker in an unlocked garage, the Raleigh
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Ga. District's Defense Plan: Assault Rifles in Safes
Police introduced idea
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Cops: Santa Monica Gunman Assembled Own Weapon
Zawahri appears to have built his AR-15 to dodge gun laws
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Shooter's family had troubled past
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Man Gets Pulled Over, Fires AR-15 at Cop
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Gunman Dead in Shooting at Houston Airport
He may have killed himself while being confronted by security
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Iowa City's Police to Buy AR-15s With Own Money
Plan would see $55 deducted from paychecks for 1.5 years
- Police in Marion, Iowa, a small city of 38,000 in the eastern end of the state, are planning to upgrade to AR-15s ... by buying the $2,000 weapon themselves, reports Fox News . Half of Marion's 50-strong police force intend to get the new weapon, and are willing to...
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We Women Need AR-15s for Self-Defense
'National Review' essayists make their case for semi-automatic rifle
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EXPLORATORY RESEARCH ON FACIOSCAPULOHUMERAL DYSTROPHY Release Date: November 8, 2000 RFA: AR-01-002 National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Neurological Disorders and Stroke Letter of Intent Receipt Date: February 1, 2001 Application Receipt Date: March 14, 2001 THIS RFA USES THE "MODULAR GRANT" AND "JUST-IN-TIME" CONCEPTS. IT INCLUDES DETAILED MODIFICATIONS TO STANDARD APPLICATION INSTRUCTIONS THAT MUST BE USED WHEN PREPARING APPLICATIONS IN RESPONSE TO THIS RFA. PURPOSE The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute of Neurological Disorders and Stroke (NINDS) invite exploratory and developmental research grant applications (R21) that will broaden the base of inquiry on Facioscapulohumeral muscular dystrophy (FSHD). HEALTHY PEOPLE 2010 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS led national activity for setting priority areas. This request for applications, Exploratory Research on Facioscapulohumeral Dystrophy, is related to the priority area chronic disabling conditions. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople/. ELIGIBILITY REQUIREMENTS Applications may be submitted by domestic or foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as Principal Investigators. Participation in the program by investigators at minority institutions is strongly encouraged. Investigators who have questions about eligibility should contact one of the program officials listed under INQUIRIES. MECHANISM OF SUPPORT Research projects will be supported with the exploratory/developmental research grant (R21). The Exploratory/Developmental research mechanism (R21) is used for support of creative, novel, and/or high risk/high payoff approaches that could produce innovative advances in this field. This includes feasibility studies, protocol planning, and the incorporation of new disciplines and technologies. This mechanism provides the means to acquire the necessary pilot information, to attract talented new investigators from related disciplines, and to foster the development of interdisciplinary, inter-institutional collaborative efforts among investigators with diverse training and expertise. Applicants may request up to three years of support. Applications for research at a single institution may request up to a maximum of $125,000 direct costs per year. Applications that include a consortium/contractual arrangement may request up to a maximum of $150,000 direct costs, including the facilities and administrative costs (indirect costs) of the consortium institution. These awards are not renewable. If desired, the specific aims of the R21 project may be incorporated into a research project grant application (R01) submitted prior to the termination of the R21 award. This RFA is a one-time solicitation. Responsibility for the planning, direction, and execution of the proposed project will be solely that of the applicant. Specific application instructions have been modified to reflect "MODULAR GRANT" and "JUST-IN-TIME" streamlining efforts. Complete and detailed instructions and information on Modular Grants can be found at https://grants.nih.gov/grants/funding/modular/modular.htm. FUNDS AVAILABLE It is anticipated that for FY 2001, approximately $1.0 million total costs will be available for the first year of support for this RFA. This funding level is dependent upon the receipt of a sufficient number of applications of high merit and on the availability of funds. It is anticipated that up to 5 new grants may be awarded in FY 2001 under this program. Direct costs will be awarded in modules of $25,000. Facilities and Administrative costs will be awarded based on the negotiated rates. Applicants may request up to three years of support. RESEARCH OBJECTIVES Background: Facioscapulohumeral muscular dystrophy (FSHD) is the third most common genetic disease of skeletal muscle. It affects approximately one in 20,000 persons. FSHD is an autosomal dominant disease that initially affects muscles of the face (facio), scapula (scapulo) and upper arms (humeral). Symptoms may develop in early childhood and are usually noticeable in the teenage years with 95% of affected individuals manifesting disease by age 20 years. A progressive skeletal muscle weakness usually develops in other areas of the body as well; often the weakness is asymmetrical. Life expectancy is normal, but up to 15% of affected individuals become severely disabled and eventually must use a wheel chair. Non-muscular symptoms frequently associated with FSHD include subclinical sensorineural hearing loss and retinal telangectasias. The pathophysiology of FSHD is not known. Muscle histologic changes are non specific for the muscle wasting. There is evidence of early inflammatory changes in the muscle, but reported responses to high dose open labeled corticosteroid treatment have been negative. Animal studies of anabolic effects of beta adrenergic agonists on models of muscle wasting led to an open trial of albuterol (a beta adrenergic agonist) in which limited preliminary results support an improvement of muscle mass and strength in FSHD. Preliminary studies of muscle cultures suggest an increased sensitivity to oxidative stress, but require further exploration. More than 95% of cases of FSHD are associated with the deletion of integral copies of a tandemly repeated 3.3kb unit (D4Z4 repeat) at the subtelomeric region 4q35. Inheritance is autosomal dominant, though up to one-third of the cases appear to be the result of de novo (new) mutations. The deletion appears to result in global dislocation of gene expression. If the entire region is removed, there are birth defects, but no specific defects on skeletal muscle. Individuals appear to require the existence of 11 or fewer repeat units to be at risk for FSHD. Though the nature of the DNA mutation is known, it has not been possible to identify a gene or mechanism that causes FSHD and a novel position effect has been postulated to explain the disease phenotype. In addition, some cases of FSHD are the result of rearrangements between subtelomeric chromosome 4q and a subtelomeric region of 10q that contains a tandem repeat structure highly homologous (95%) to 4q35. Disease occurs when the translocation results in a critical loss of tandem repeats to the 4q site. Finally, there is a large family with a phenotype indistinguishable from FSHD in which no pathological changes at the 4q site or translocation of 4q-10q are found. NIAMS and NINDS sponsored a conference on FSHD in May 2000. This was followed by a brief session in which researchers considered possible approaches for increasing knowledge about the pathogenesis and treatment of the disease. A brief summary may be seen at: http://www.nih.gov/niams/reports/fshdsummary.htm Scope and Objectives: The NIAMS and NINDS seek to broaden the base of knowledge concerning the pathogenesis of FSHD and possible therapies by encouraging exploratory research. Because exploratory projects may require a preliminary test of feasibility, this initiative will provide short-term support for such preliminary work. Each research plan should begin with a short paragraph describing the feasibility of the approach to increase knowledge about disease pathogenesis and disease processes that might be ameliorated. Applications in response to this RFA should address issues related to characterizations and pathogenesis of FSHD. Examples of areas included in this RFA are listed below. o Characterize the molecular pathogenesis of FSHD and elucidate the role of the 3.3 kilobase tandem repeats in maintaining of heterochromatin structure and the mechanism of tandem repeat deletions in this critical region of 4q. o Determine the relationship between repeat length and its effect on penetrance. Determine also whether the loss of certain repeats is always associated with FSHD clinical expression, since there may be specificity in chromosomal transactions and the resulting pathogenesis. o Determine the gene sequence and whether the repeats are acting as suppressors or insulating units. The region containing the site associated with at least 95% of FSHD cases is composed almost entirely of the 3.3 kilobase repeats, which are not translated. Few genes have been found near the multi-repeat locus, suggesting that FSHD may result from alterations in the chromatin structure. In particular, the data suggest that you need a minimum size of repeats in order to have a compact heterochromatin structure. o Clarify how similarity of regions on chromosomes 4 and 10 may relate to FSHD. There is a region on chromosome 10 that appears to be largely identical (95% homology) to that on chromosome 4 at the FSHD locus (4q35). Studies on affected and unaffected populations show that there is a high amount of exchange between the homologous regions on chromosomes 4 and 10. Although disease has never been associated with alterations on chromosome 10, the frequency of such exchanges may be related to the high proportion of new (i.e., non-familial) cases of FSHD encountered. o Characterize changes in muscle as the disease develops. This would be facilitated by non-invasive ways of looking at the muscle and microvasculature in affected and non-symptomatic regions. Studies using improved imaging techniques would provide better assessment of patient muscle, including vasculature, that is pre-atrophic. o Determine basis of differential involvement of muscles, reflected by the regional pattern of disease. Comparison of muscle groups might show the cause of relative specificity of affected muscles. Comparing expression patterns of RNA and protein in affected and non-affected muscle will provide insights into alterations occurring as the disease progresses. o Explore the role of inflammation in FSHD. While FSHD has been described as the most inflammatory form of muscular dystrophy, there is no evidence that disease severity is lessened by administration of the anti-inflammatory drug prednisone. It is necessary to explore the relationship between inflammatory cells, muscle cell death, and blood vessels. o Study properties of muscle cells derived from affected tissue. Cells cultured from FSHD muscle show increased sensitivity to oxidative stress. This needs to be followed up by studies verifying that this occurs in vivo and establishing how this cellular phenotype develops. o Determine if a nonstandard locus produces FSHD. Characterize the gene defects in the family with FSHD phenotype but no linkage to the 4q35 locus to pursue a better understanding of FSHD disease processes. o Create new models of FSHD. The development of new models of the genetic pathogenesis of FSHD would provide a tool to research scientists in muscle biology, attracting new investigations to pursue understanding of disease pathogenesis and eventual therapies for FSHD. INCLUSION OF WOMEN AND MINORITIES IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of the NIH that women and members of minority groups and their subpopulations must be included in all NIH supported biomedical and behavioral research projects involving human subjects, unless a clear and compelling rationale and justification are provided that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing research involving human subjects should read the UPDATED "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research," published in the NIH Guide for Grants and Contracts on August 2, 2000 (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-048.html); a complete copy of the updated Guidelines are available at https://grants.nih.gov/grants/funding/women_min/guidelines_update.htm: The revisions relate to NIH defined Phase III clinical trials and require: a) all applications or proposals and/or protocols to provide a description of plans to conduct analyses, as appropriate, to address differences by sex/gender and/or racial/ethnic groups, including subgroups if applicable; and b) all investigators to report accrual, and to conduct and report analyses, as appropriate, by sex/gender and/or racial/ethnic group differences. Investigators also may obtain copies of the policy from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. INCLUSION OF CHILDREN AS PARTICIPANTS IN RESEARCH INVOLVING HUMAN SUBJECTS It is the policy of NIH that children (i.e., individuals under the age of 21) must be included in all human subjects research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them. This policy applies to all initial (Type 1) applications submitted for receipt dates after October 1, 1998. All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines" on the Inclusion of Children as Participants in Research Involving Human Subjects that was published in the NIH Guide for Grants and Contracts, March 6, 1998, and is available at the following URL address: https://grants.nih.gov/grants/guide/notice-files/not98-024.html. Investigators also may obtain copies of these policies from the program staff listed under INQUIRIES. Program staff may also provide additional relevant information concerning the policy. LETTER OF INTENT Prospective applicants are asked to submit, by February 1, 2001, a letter of intent that includes a descriptive title of the proposed research; the name, address, and telephone number of the Principal Investigator; the identities of other key personnel and participating institutions; and the number and title of this RFA. Although a letter of intent is not required, is not binding, does not commit the sender to submit an application, and does not enter into the review of a subsequent application, the information that it contains allows NIH staff to estimate the potential review workload and avoid conflict of interest in the review. The letter of intent is to be sent (e-mail, fax or post) to Dr. Tommy Broadwater at the address listed under INQUIRIES. APPLICATION PROCEDURES The research grant application form PHS 398 (rev. 4/98) is to be used in applying for these grants, with the modifications noted below. These forms are available at most institutional offices of sponsored research; from the Division of Extramural Outreach and Information Resources, National Institutes of Health, 6701 Rockledge Drive, MSC 7910, Bethesda, MD 20892-7910, telephone 301/710-0267, Email: email@example.com; and on the Internet at https://grants.nih.gov/grants/funding/phs398/phs398.html. The RFA label found in the PHS 398 (rev. 4/98) application form must be affixed to the bottom of the face page of the application. The RFA label and line 2 of the application should both indicate the RFA number. Failure to use this label could result in delayed processing of the application such that it may not reach the review committee in time for review. The sample RFA label available at: https://grants.nih.gov/grants/funding/phs398/label-bk.pdf has been modified to allow for this change. Please note this is in pdf format. For purposes of identification and processing, item 2a on the face page of the application must be marked "YES" and the RFA number "AR-01-002" and the words "EXPLORATORY RESEARCH ON FACIOSCAPULOHUMERAL DYSTROPHY" must be entered on the face page. BUDGET INSTRUCTIONS Modular grant applications that include a consortium/contractual arrangement may request direct costs in $25,000 modules up to a yearly maximum of $150,000 direct costs, including the facilities and administrative costs (indirect costs) for the consortium institution. Applications proposing research at a single institution may request up to a maximum of $125,000 direct costs per year. The total direct costs must be requested in accordance with the program guidelines and the modifications made to the standard PHS 398 application instructions described below: PHS 398 o FACE PAGE - Items 7a and 7b should be completed, indicating Direct Costs (in $25,000 increments up to a maximum of $125,000 for research at a single institution, or up to a maximum of $150,000 for research involving a consortium/contractual arrangement) and Total costs (Modular Total Direct plus Facilities and Administrative (F&A) Costs) for the initial budget period, and Items 8a and 8b should be completed indicating the Direct and Total Costs for the entire proposed period of support. o DETAILED BUDGET FOR THE INITIAL BUDGET PERIOD - Do not complete Form Page 4 of the PHS 398. It is not required and will not be accepted with the application. o BUDGET FOR THE ENTIRE PROPOSED PERIOD OF SUPPORT - Do not complete the categorical budget table on Form page 5 of the PHS 398. It is not required and will not be accepted with the application. o NARRATIVE BUDGET JUSTIFICATION - Use a Modular Grant Budget Narrative page. (See https://grants.nih.gov/grants/funding/modular/modular.htm for sample pages.) At the top of the page, enter the total direct costs requested for each year. o Under Personnel, list all project personnel, including their names, percent of effort, and roles on the project. No individual salary information should be provided. o For Consortium/Contractual costs, provide an estimate of total costs (direct plus facilities and administrative) for each year, each rounded to the nearest $1,000. List the individuals/organizations with whom consortium or contractual arrangements have been made, the percent effort of all personnel, and the role on the project. Indicate whether the collaborating institution is foreign or domestic. The total cost for a consortium/contractual arrangement is included in the overall requested modular direct cost amount. Include the letter of intent to establish a consortium. Provide an additional narrative budget justification for any variation in the number of modules requested. o BIOGRAPHICAL SKETCH - The Biographical Sketch provides information used by reviewers in the assessment of each individual's qualifications for a specific role in the proposed project, as well as to evaluate the overall qualifications of the research team. A biographical sketch is required for all key personnel, following the instructions below. No more than three pages may be used for each person. A sample biographical sketch may be viewed at: https://grants.nih.gov/grants/funding/modular/modular.htm. - Complete the educational block at the top of the form page; - List position(s) and any honors; - Provide information, including overall goals and responsibilities, on research projects ongoing or completed during the last three years; - List selected peer-reviewed publications, with full citations. o CHECKLIST - This page should be completed and submitted with the application. If the F&A rate agreement has been established, indicate the type of agreement and the date. All appropriate exclusions must be applied in the calculation of the F&A costs for the initial budget period and all future budget years. o PAGE LIMITATION - In keeping with the pilot/feasibility nature of the requested studies the application (aims, background and significance, preliminary data and experimental design and methods) is limited to 20 pages. Tables and figures are included in the 20-page limitation. o APPENDIX - An appendix or additional supporting materials will not be accepted with the exception of originals of photos used in the application. o The applicant should provide the name and phone number of the individual to contact concerning fiscal and administrative issues if additional information is necessary following the initial review. APPLICATIONS NOT CONFORMING TO THESE GUIDELINES WILL BE CONSIDERED UNRESPONSIVE TO THIS RFA AND WILL BE RETURNED WITHOUT FURTHER CONSIDERATION. Submit a signed typewritten original of the application and three signed photocopies, in one package to: CENTER FOR SCIENTIFIC REVIEW NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE, ROOM 1040 - MSC-7710 BETHESDA, MD 20892-7710 BETHESDA, MD 20817 (for express/courier service) At the time of submission, two additional copies of the application must be sent to: Tommy L. Broadwater, Ph.D. Scientific Review Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases 45 Center Drive, Room 5AS-25U - MSC 6500 Bethesda, MD 20892-6500 Telephone: (301) 594-4952 FAX: (301)-402-2406 Email: firstname.lastname@example.com In order not to delay review, it is important that applicants comply with this request. Applications must be received by March 14, 2001. If an application is received after that date, it will be returned to the applicant without review. Only one R21 grant application may be submitted by a Principal Investigator. REVIEW CONSIDERATIONS Upon receipt, applications will be reviewed for completeness by CSR and responsiveness by NIAMS and NINDS. Incomplete and/or non-responsive applications will be returned to the applicant without further consideration. Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review group convened by the NIAMS in accordance with the review criteria stated below. As part of the initial merit review, all applications will receive a written critique and under a process in which only those applications deemed to have the highest scientific merit, generally the top half of the applications under review, will be discussed, assigned a priority score, and receive a second level review by the appropriate national advisory council. Review Criteria The goals of NIH-supported research are to advance our understanding of biological systems, improve the control of disease, and enhance health. For this initiative, the proposed project must have the potential for developing approaches or information that may lead to significant increases in understanding or treating FSHD. In the written review, comments on the following aspects of the application will be made in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered in the assignment of the overall score. (1) Significance. Does this study address issues important to understanding and treating FSHD? If the aims of the application are achieved, how will scientific knowledge about FSHD be advanced? What will be the effect of these studies on the concepts or methods that drive research on FSHD? (2) Approach. Are the conceptual framework, design, methods, and analyses adequately developed, well-integrated, and appropriate to the aims of the project? Does the investigator acknowledge potential problem areas and consider alternative tactics? (3) Innovation. Does this application have the potential for ground breaking advances that may lead to new approaches to research on FSHD? Does the project employ novel concepts, approaches or method? Are the aims original and innovative? Does the project challenge existing paradigms or develop new methodologies or technologies? If the project is not innovative but is essential to move the field forward, the applicant should mention and discuss this aspect in the proposal. (4) Investigator. Is the investigator appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers (if any)? (5) Environment. Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed experiments take advantage of unique features of the scientific environment or employ useful collaborative arrangements? Is there evidence of institutional support? The initial review group will also examine the provisions for the protection of human and animal subjects, the safety of the research environment, and conformance with the NIH Guidelines for the Inclusion of Women, Minorities and their subgroups, and children as Subjects in Clinical Research. The personnel category will be reviewed for appropriate staffing based on the requested percent effort. The direct costs budget request will be reviewed for consistency with the proposed methods and specific aims. Any budgetary adjustments recommended by the reviewers will be in $25,000 modules. The duration of support will be reviewed to determine if it is appropriate to ensure successful completion of the requested scope of the project. AWARD CRITERIA The following will be considered in making funding decisions: o Scientific merit of the proposed project as determined by peer review; o Importance of the area to understanding and treating FSHD; o Potential for ground breaking advances that may lead to new approaches to research on FSHD; and o Availability of funds. INQUIRIES Inquiries concerning this RFA are encouraged. The opportunity to clarify any issues or questions from potential applicants is welcome. Direct inquiries regarding programmatic and scientific issues to one of the following persons: Richard W. Lymn, Ph.D. Muscle Biology Program National Institute of Arthritis and Musculoskeletal and Skin Diseases 45 Center Drive, Room 5AS-49E Bethesda, MD 20892-6500 Telephone: (301) 594-5128 FAX: (301) 480-4543 Email: email@example.com Giovanna M. Spinella, M.D. Division of Fundamental Neuroscience and Developmental Disorders National Institute of Neurological Disorders and Stroke 6001 Executive Boulevard, Room 2132 Bethesda, MD 20892 Telephone: (301) 496-5745 FAX: (301) 402-0887 Email: firstname.lastname@example.com Direct review inquiries to: Tommy Broadwater, Ph.D. Review Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases 45 Center Drive, Natcher Bldg. Rm. 5A25U Bethesda, MD 20892-6500 Telephone: (301) 594-4952 FAX (301) 480-4543 Email: email@example.com Direct inquiries regarding fiscal matters to: Melinda Nelson Grants Management Officer National Institute of Arthritis and Musculoskeletal and Skin Diseases 45 Center Drive, Room 5AS-49F, MSC 6500 Bethesda, MD 20892-6500 Telephone: (301) 594-3535 FAX: (301) 480-5450 Email: firstname.lastname@example.com Karen D. Shields Grants Management Branch National Institute of Neurological Disorders and Stroke 6001 Executive Boulevard, Room 3264 Bethesda, MD 20892 Telephone: (301) 496-9231 FAX: (301) 402-0219 Email: firstname.lastname@example.com AUTHORITY AND REGULATIONS This program is described in the Catalog of Federal Domestic Assistance No. 93.846 (NIAMS) and No. 93.853 (NINDS). Awards are made under authorization of sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and administered under NIH grants policies and Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. This program is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. The PHS strongly encourages all grant and contract recipients to provide a smoke free workplace and promote the non-use of all tobacco products. In addition, Public law 103-227, the pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care or early childhood development services are provided children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
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