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The Literary FrontierBy Fred Shedian
Posted at August 2, 1999 - 5:00 AM GMT
When a person talks about the Star Trek Franchise, most of the time they are referring to the television shows and theatrical releases. Novels and other writings not seen are normally not considered "canon" within the universe, cast aside by quite a few readers as not important. Yet, these books were what kept the franchise alive and mysterious in the 70's and 80's. Although a movie would come out now and again, novels brought people in and continued character development. In recent years, have the importance of these literary works been downplayed?
We have been watching consistent Trek for an extended period of time now. The viewers have a solid source of entertainment to keep their addiction to the show under control. Yet, it is the novels that help us to really understand who our beloved characters are. A simple book using an episode as it's basis reveals so much more. In cases like this, many times the book is closer to the original concept of the script. The book "Relics" comes to mind.
Regretfully, as more television based Trek has entered our homes, it seems that the number of paperback Star Trek is on the decline. The quality of stories are better than ever, yet when I look in bookstores I see more and more unsold books for TOS, TNG, DS9, and VOY. Is it possible that people have forgotten to investigate these important resources the franchise has produced?
I have to agree with the majority of book readers when I say that the writers TV Star Trek could get some valuable help from novel writers. These individuals seem to have a more consistent approach to characterization, development of a show, and overall quality performance. Reading over some of the Voyager books, I am in awe and wonder why these folks are not in Hollywood writing the visual version.
A problem our society faces is the fact many do not comprehend the importance and educational use of reading. To an extent, reading material on a computer helps with the comprehension. However, I believe most can agree that nothing sparks our imaginations better than a good book.
In a time when many fans are annoyed or disenchanted with what we see each week, perhaps salvation can be found in the literary version?
I invite everyone to take an adventure back with Doctor McCoy shortly before his retirement in the late 2260's, see what adventures Captain Sulu encountered as he commanded the Excelsior, learn about how the Klingon Empire found honor within it's enemies, find out about the emergency aboard the Enterprise-E days before her commissioning, discover what sparked Kira's promotion, and learn about the early adventures of Captain Janeway before Voyager.
They sound like interesting episode promos, don't they? The best part is, if these were turned into an episode some would run four hours long and keep us entertained the entire time. I hope everyone will take an opportunity to investigate the franchise within the Star Trek Franchise, one in which Pocket Books takes us to: "Space, the literary frontier."
Fred Shedian writes a weekly 'A Take On Trek' column for the Trek Nation.


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Costume jewellery necklace, help me find a chunky nice one for summer!(2 Posts)
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Board Member at Old Republic International Corporation
Director since 2004. Formerly Director - Insurance Group with Standard & Poor's Corp. until 2003. He brings significant business experience and knowledge of the risk factors connected with the insurance industry by virtue of his long career as a lending officer with a major banking institution and with the aforementioned rating agency.
Source: Old Republic International Corporation on 04/14/2017
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BROOKLYN TROLLEY CRASH.; Half a Dozen Persons Slightly Injured -- Woman's Narrow Escape.
Half a dozen persons were slightly injured and a car partially wrecked in a trolley accident in Brooklyn yesterday afternoon on Smith Street, between Atlantic Avenue and Pacific Street. Workmen had been repairing the street, and considerable loose earth had been filled in over the crown of the sewer.
May 19, 1900
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People in everyday life leave traces of their activities. I like to use portraits to capture these traces and details. The portraits represent not only the look and appearance of the subjects, but also communicate layers of meaning. Different viewers will have different feelings about it and interact with it in a different way so that it reflects their own everyday life. These are the elements and the significance that I want my paintings to convey to viewers.
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Examiner.com article: To Transform a City, begin with your neighbors
I've published another article as the "Raleigh Practical Christianity Examiner" on Examiner.com. The article is called "To Transform a City, begin with your neighbors."
As you may have guessed, the articles introduces the book To Transform a City by Eric Swanson and Sam Williams. Since Examiner.com articles can only be 200-300 words, I had to be very brief.
Here is the introduction to my article:
Around the United States, and even in North Carolina in the "Bible belt," Christians are concerned about the death of "Christian America." While some decry the loss of Christendom and privileges for Christian organizations, others see opportunities for discipleship.
Please jump over to Examiner.com, read my new article, and interact with it there.
One Comment
Comments are closed. If you would like to discuss this post, send an email to alan [at] alanknox [dot] net.
Great article Alan!


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Montview Playground
See all playgrounds in Hornsby Heights
Playground added by clare, March 12, 2013
This playground is fenced, is suitable for toddlers, has sun shade, is suitable for all abilities, has seats, has tables, is near a bikepath
A large fenced playground with trees, picnic tables, swings and a bike path. The play equipment proper includes 2 slides, 2 nets, a climbing wall, clock, stepping stones, spinner and rockers. Next to a large oval and basketball courts and near a toilet block, toddlers' playground and a BMX track, so something for everyone! Not too busy either. :)
Review by clare, March 12, 2013


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In Stock
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Label: Hatology
Catalog ID: Hatology620
Squidco Product Code: 7201
Format: CD
Condition: New
Released: 2006
Country: Switzerland
Packaging: Cardstock foldover
Recorded January 16th, 1969 in Los Angeles by J.W. Hardy and Pete Welding.
John Carter-alto, tenor saxophone, clarinet, flute
Bobby Bradford-trumpet
Tom Williamson-doublebass
Bruz Freeman-drums
Highlight an artist name or instrument above
and click here to Search
1. In the Vineyard 10:30
2. Karen on Monday 6:50
3. Sticks and Stones 6:17
4. The Village Dancers 8:50
5. Seeking 6:31
6. Song for the Unsung 7:57
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descriptions, reviews, &c.
"This was the debut on disc of the John Carter - Bobby Bradford Quartet (then under the cooperative name New Art Jazz Ensemble), and captures their marvelous cohesiveness, moral vibrancy, and quiet determination in equal measure. Subsequent recordings (and there were precious few of them) may have widened our view of their talents slightly, but didn't necessarily alter any early assessment of their unique capabilities. Their music was fresh and vital from the git-go, and remains so."-Art Lange, from the CD liner notes


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Date: June 14, 2017 08:30 AM
Contact: Andrea Gross, 800-622-4971: ext. 2301
Location: College of St. Benedict's850 Abbey Plaza, Collegeville
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Season 1 of Teaching and Learning Moments with Teacher Plus had educationists discussing solutions to the various problems that teachers face in their classrooms. In Season 2 we feature artists who talk about the major influences of teachers/mentors in their lives and the unique perspective that they bring to their students.
This week we talk to Ravi Kumari Kashi—painter, sculptor, photographer and installation artist. His work explores everyday themes such as desire, gratification and consumerism. Kashi is also a Sahitya Akademi Award winner. He writes in Kannada and English.
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NFL Scoring Down Big Through Week 2 ESPN Sees Ratings Increase For Week 2 "MNF" Chargers/Rams Officials Stand Behind L.A. Market Blank Says Jones-Goodell Report "Mischaracterized" Newgarden Could Be Key For IndyCar In '18 NBA 2K Esports League Dir Breaks Down Venture League Notes "SNF" Week 2 Is Lowest Rating In A Decade Jones Denies Impeding Goodell Extension Talks NFL Players To Soon Begin Voting On De Smith's Future
Upcoming Conferences and Events
SBD/March 4, 2014/Leagues and Governing Bodies
Foot Fault? NFL Considers Experimenting With Extra-Point Attempts From 25-Yard Line
Published March 4, 2014
PLAYOFF EXPANSION A GOOD THING? In addition to the extra point, one of the main NFL talking points this offseason is the potential expansion of the postseason to 14 teams. Reports that support is growing for adding two teams to the playoffs has generated a lot of chatter on sports talk TV shows in recent days. ESPN's Dan Le Batard said adding teams to the playoffs is "diluting everything" accomplished in the regular season. Le Batard: "You're making the 16 games right now -- each one of them that matters more than regular-season games matter in other sports -- matter a lot less." ESPN's Bomani Jones said, "Go look at who just missed the playoffs this last year and you tell me how many of those teams you really wanted to see play another down of football. There really aren't that many of them. We've got enough" ("Highly Questionable," ESPN, 2/28). FoxSports.com's Bill Reiter said, "I hate it on every single level. ... This protects mediocrity. Some team that should have their GM and their head coach on the hot seat instead gets to pretend they had success because at 9-7 they made the playoffs" ("Rome," CBSSN, 2/28). ESPN's J.A. Adande said, "It's one more game but it's a diluted game. ... The playoffs should not be the province of mediocre." The Dallas Morning News' Tim Cowlishaw said that the league is "eventually going to get to 16 teams in the playoffs," but thinks that is "too much" ("Around The Horn," ESPN, 2/28).
ALL ABOUT THE BENJAMINS: The Boston Globe's Bob Ryan said expanding the NFL playoffs is "not the worst thing that ever happened and it's certainly something that is predictable." He added, "It's about making money. It's about the opportunity to open up the gates one more time for everybody involved." Columnist Kevin Blackistone said expansion of the playoffs is "all about cheddar" and the league "is even talking about putting that playoff game right on Monday night where they know they can even sell more ads" ("Around The Horn," ESPN, 2/28). WEEI-FM's Michael Holley said the NFL right now is "the one sport ... where there is a true sense of genuine accomplishment about making the playoffs." He added, "This is such an obvious money grab. There is not a demand for this" ("Numbers Never Lie," ESPN2, 2/28). CBS Sports Network's Jim Rome said playoff expansion is "about two things: Getting two extra playoff games on TV during the first weekend and getting the Cowboys into the playoffs, which means it's really about one thing, money." CBSSports.com's Bruce Feldman said, "This is how the NFL got to be the king, because the NFL has the most business sense" ("Rome," CBS Sports Network, 2/28). NFL Network's Heath Evans said the NFL's current playoff system is the "best of the best, and America proves it every year by the ratings we get." But the reason teams will likely be added is because the "ratings we get are so good" ("NFL Total Access," NFL Network, 2/28).


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Enquire allowed me to understand what my child was entitled to educationally and how the school should be supporting my son – helped relieve my anxieties.
What is additional support for learning?
Additional support for learning means giving children extra help or support so they can get the most out of their education.
A child or young person is said to have 'additional support needs' if they need more – or different support – to what is normally provided in schools or pre-schools to children of the same age.
It doesn't just apply to children who have long-term learning difficulties or disabilities. Children can need support for many reasons. Some may need a lot of support all the way through school. Others will only need a small amount for a short time.
Read our handy summary – Understanding the basics: What is additional support for learning?
Find more detailed advice and information about additional support for learning in our guides and factsheets.
Additional Support for Learning isn't just a good idea – it's the law.
The Education (Additional Support for Learning) (Scotland) Act 2004 came into force in 2005 and was amended in 2009. The law sets out how pupils should be helped to get the right support to become successful learners and explains how parents can make sure this happens.
To find out what the law means in practice see The parents' guide to additional support for learning. For more information on amendments contained in the 2009 Act see our two page summary – ASL-Act-2009-changes
You can view the 2004 Act in full, and the full 2009 Act is also available. Supporting children's learning code of practice is the guidance which explains the law.


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Reviews - The Living Room4
2 Drury Road, Alum Chine,, Bournemouth, BH4 8HA
Customer Reviews
Our reviews are from genuine LateRooms.com customers. We verify that the customer has stayed before leaving a review.
96% would recommend it to a friend
Customer service
Food quality
Room quality
The Living Room
A brilliant find, thank you.
Very friendly - Breakfast fantastic! loads to choose.
Relaing stay at a comfortable. quirky B&B
the Living Room is in a really good position between Westbourne shops and restaurants and the sea via Alum Chine.
The bed was really comfortable. The room had all we needed including 2 comfortable chairs. the breakfasts were great
Read More Less
family day trip
2 adults 2 children 10 years and 3 years in the family room.
We had a very warm welcome and the room was great kids straight to their room lovely and clean everything was great. A stroll down to the beach took 10.minutes along to the pub for dinner and back. Lovely bath for the kids adults had a shower which was the only let down, the power of the shower was not really any use so would recommend getting that sorted but we were at the top of building so understandable. Other then that the stay was brilliant would definitely recommend.
Read More Less
Beautiful quirky place, friendly atmosphere, amazing breakfast
Lovely room and bathroom (water pressure slightly lacking but walled in shower keeps you warm), full range of really delicious breakfasts and really friendly staff.
The downstairs lounge/coffee area would have been a great place to spend time if we'd had more of it. Free brownies were gorgeous!
Read More Less
Second visit
Lovely welcome.
A very comfortable room with a great shower. There is a really nice atmosphere of home from home.
Read More Less
pleasent bed and breakfast
Stayed here for a weekend break.
Pleasant greeting on arrival and shown where the essentials were, the dinning room. Room was small but big enough for two nights with usual tea and coffee facilities. Added bonus of free homemade brownies and flapjacks in an airtight container on the landing with a selection of books and magazines. Room would have got 5 stars if it weren't for the loss of water pressure in the shower in the morning. Breakfast was excellent and I even purchased a slice of homemade banana cake with cinnamon butter for the drive home on the Sunday. Would I go back. Definitely.
Read More Less
The Living Room - Salubrious. Great bath mats. February 2015.
Situated a short walk from Westbourne and its useful amenities including shops, restaurants and cafés; this spacious accommodation with its charming hosts, was just the healing respite that The Doctor (46) had ordered.
I would have liked to stay longer to have taken advantage of the proximity to beach, potential walks, and the great food. (Compliments to the chef.) The proprietor of this establishment should feel justifiably proud in the standard of property and customer service that they offer. I intend to return.
Read More Less
Great Stay
We were only there for one night, but would have happily stayed longer.
The Hostess and Host were very warm and welcoming and even though we arrived early our room was ready. The room was beautifully decorated and cosy and had everything we wanted. The Breakfast menu was to die for and we were spoilt for choice. There was also a coffee shop which we did not use but the menu looked very inviting. Would definitely recommend to friends and would stay again.
Read More Less
The Living Room
Easy to find and a warm welcome from the owner who couldn't have been more friendly and helpful with information about the local area.
Lovely room and breakfast - chocolate brownies in the room were an added bonus.
Read More Less
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- 1
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text: I'm thinking about selling my boat, so here you go. It's a 2004 moomba mobius LS gravity games edition with 115 hrs, 310 hp indmar 350, wakeplate, perfect pass, gravity ballast (1250 or 1500lbs I'm not sure),bimini top, depth sounder, heater, hot/cold shower, drivers seat with adjustable height bolster, heavy duty factory moomba cover, new steering cable, just added kicker sub and polk tower speakers and 2 amps. I upgraded the cd player to the kenwood kdc 232 mr to play burned cd's and it has a drivers remote. I can sell with or without the system since the tower speakers haven't been installed yet. It's been a great boat with a great wake and it has every option you can think of. I'm looking for 27,500 without the system or 28,500 with it and I will finish installing the tower speakers.


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Phruby, ya know i almost got going last night, i had the house to myself, but i opted to finish my wifes garden for her. So, i'll get started tomorrow!
Boy dont i know what you mean chewie, I'm only averageing 50 hrs a week, but all my spare time, i'm doing the stuff my wife "shouldnt" be doing.
Page created in 0.062 seconds with 18 queries.


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One thing you can expect to see a lot more of, now that Google purchased SketchUp (a popular 3D modeling package which will probably become the most popular in the world now), is a surge in the number of 3D models in Google Earth. If Google will release a new version of GE that supports texture mapping (which allows you to put photo textures onto sides of 3D models), you would have even more realistic looking models. Maybe the next release will have this. Anyway, here's a list of just a few of the best new 3D models for GE published in the last week:
- Mikimoto Store in Tokyo, Japan – This unique building (shown in the picture above) was modeled by 'pivnice' and published at his blog ZNO – I call it the Swiss Cheese building 🙂
- Glen Canyon Dam, Arizona – Excellent model! Posted by 'jpwade', it really fits in well with the 3D terrain.
- Casa Malaparte in Capri, Italy – sometimes known as the most beautiful house in the world. Posted by 'pivnice'.
- Blender Gets in Way – Stefan Geens at OgleEarth decides to play with SketchUp – see his post. for why this is funny.
- Aurland Lookout – 'pivnice' again, a unique bridge structure in the fjords of Norway
For all the 3D models blogged here, read the 3D Models Category.
About Frank Taylor
Frank Taylor started the Google Earth Blog in July, 2005 shortly after Google Earth was first released. He has worked with 3D computer graphics and VR for many years and was very impressed with this exciting product. Frank completed a 5.5 year circumnavigation of the earth by sailboat in June 2015 which you can read about at Tahina Expedition, and is a licensed pilot, backpacker, diver, and photographer.


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The Word's out. We're getting a reputation. Xlibris delivers the best in marketing solutions. Consistently delivering quality as well as timely campaigns and author-centric services will do that. But, don't take it from us. Here's what our authors have to say…
Judy K. SniderGoldy's Baby Socks
"Xlibris' marketing services, especially the online listing and channel program, helped my book 'get out there'. I am so happy with Xlibris that I just signed up with them to get my book done in Spanish. Thanks so much."
Will-Allen JamesonUnraveling at Glory House, Too Tough to Die, Too Poor to Leave
"I couldn't improve on your marketing message for my book. You did a great job!! Thanks so much for your time, interest, and talent. I'm very pleased with your work"
Diana Harrison1409
"I am very happy with the Web Design Marketing Service. Again, thanks much for all that you have done."
Maurice C. FillionPriest
"You've moved my Email Marketing Campaign with speed and effectiveness. I appreciate your courtesy and your dedication"
Jean SolbertWhy We Go Hunting
"The EMC and the info sent have satisfied me in every way. The e-mail creative ad was so perfectly written. Really unbelievable. I am very pleased."
Kim TennantThe Ordinary Extraordinary Boy
"One thing I have truly enjoyed about dealing with Xlibris is the staff is so helpful and courteous, and also that the internet communication is quick and efficient."
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|Principal Amount
|Principal Amount
|Tendered as of the Early
|Title of Old Notes
|Participation Date
|8.80% Subordinated Notes due 2019
|$1,186,184,000 (79.08%)
Capital One Financial Corporation (NYSE: COF) announced today that its subsidiary, Capital One Bank (USA), National Association ("COBNA") received the early tender results of its previously announced offer to exchange any and all of its outstanding 8.80% Subordinated Notes due 2019 (the "Old Notes") for a combination of new Subordinated Notes due 2023 (the "New Notes") and cash. Based on information provided by D.F. King & Co., Inc., the exchange agent for the exchange offer, the aggregate principal amount of the Old Notes validly tendered for exchange and not validly withdrawn as of the early participation date for the exchange offer (5:00 p.m., New York City time, on February 5, 2013) will satisfy the minimum size condition with respect to the New Notes to be issued pursuant to the terms and conditions of the exchange offer. The following table indicates, among other things, the principal amount of the Old Notes validly tendered for exchange as of the early participation date:
The exchange offer will expire at 11:59 p.m., New York City time, on February 20, 2013, unless extended or earlier terminated by COBNA. In accordance with the terms of the exchange offer, tendered Old Notes may no longer be withdrawn following the early participation date, except in certain limited circumstances where additional withdrawal rights are required by law. COBNA expects to deliver the New Notes and cash in exchange for accepted Old Notes on February 11, 2013 (in the case of Old Notes tendered and accepted for exchange at or prior to the early participation date) and on February 22, 2013 (in the case of Old Notes tendered and accepted for exchange after the early participation date but at or prior to the expiration date).


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Sasha is a fan of this new action flick staring Denzel Washington.
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Tell him as much as I agree with him , that he is not worth going to prison over, that his daughter would not want that.
Quoting Rivera Ancient:"
Quoting E&J=my world:" Hm, not quite. If he's sentenced to death, ... [snip!] ... doing so, or even planning it."
 So you're okay with murder, if you're not the one doing it. Got it.
Some could say you also seem to think it's ok if you did not report this, and allowed it to happen as a result of that! You should be reporting this to the police!
Quoting Rivera Ancient:"
Quoting ♥Love♥:" Why not think that? I could not trust ... [snip!] ... You wouldn't want someone dead who murdered your baby? Personally I think it's a pretty understandable reaction."
This. I have said it many times on here before... unless I had another kid, if someone killed Lily they'd be dead. No joke. I wouldn't have mercy either. And if that earns me the death chair or life in prison I'd consider it justice and A-ok, because Id find it worth it.
I dont get the "I might be next" attitude... dude I wouldnt kill anyone in the world unless they hurt Lily. I wouldn't tear apart her killer and then turn around and kill the man I love... it makes no sense.
If someone kills my child, they are going to die a slow and painful death if they ever get out of prison. I would not care if that meant prison or death for me.
I am guessing that everyone in here that says they would seriously kill anyone that hurt/killed their child has only one child... because you're all saying that you wouldn't care about going to prison...
Because if you have more children, where does a dead sibling and a mom in prison get them in life?

Quoting The Pretender:" I am guessing that everyone in here that says they would seriously kill anyone that hurt/killed their ... [snip!] ... about going to prison... Because if you have more children, where does a dead sibling and a mom in prison get them in life?"

If any one of my children were murdered like the one described in this thread, I would lose my mind.. I would have to live every day knowing how my child left this earth. I couldn't do it. I could not possibly live knowing that the evil p***e o* s**t who did that to them was free to live their life and hurt someone else's child. I would do my best not to get caught. If it wasn't me that killed him, it would be someone else in my family. It's easy to say "let the justice system do it's job" but if it were my child, I know I wouldn't be that rational.


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The Minnesota Senate rejected an elections bill today that would have created an earlier primary date in Minnesota.
The Senate voted 35-30 to send the bill back to conference committee for further negotiations. The move doesn't kill the bill for the session, but it sends a signal that the Senate was not in favor of a June primary. Several senators, including Sen. Dick Cohen, DFL-St. Paul and Sen. Warren Limmer, R-Maple Grove, said the June primary would create longer election seasons in Minnesota.
"What I hear when people discuss elections is that people find the length of elections tiresome," Cohen said.
Supporters say a June primary would increase voter turnout. They complained that the current August primary comes at a time when many people are vacationing.
"We all know that there's a tradition of vacationing in August," said Sen. Terri Bonoff, DFL-Minnetonka. "A June primary allows more people to participate in the process."
Bonoff also mentioned that the leaders in the DFL and Republican Parties supported the move to an earlier primary.
Today's Senate action comes several weeks after the House voted to move the primary to June. The conference committee will have to meet again to determine whether it should keep the June primary in the bill that includes several other elections issues.
Gov. Mark Dayton said he supports a June primary.


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New York (Oct. 10)
Funeral services were held today for Rabbi Hirsch Manischewitz, 52, vice-president of the famous baking firm founded by his parents, who died of a heart attack during Yom Kippur services at the Congregation Ohab Zedeb here. Born in Cincinnati, whither his parents, Rabbi Dov Ber and Natalie Rose Manischewitz, had migrated from Memel, Lithuania, a few years earlier, Rabbi Manischewitz was educated in Palestine at Yeshivoth Etz Chaim, 1901-07; Torath Chaim, 1908-10, and Meah Shearim, 1910-14. In August, 1914, he returned to Cincinnati, where he remained until 1931, when he moved to New York.
A representative of more than thirty institutions or organizations of higher Jewish learning in Europe and Palestine, Rabbi Manischewitz was president of the Federation of Palestine Jews, Israel Orphans Home for Girls in Jerusalem, Beth Yeshomin Eishel of Warsaw, vice-president of the Mizrachi Organization of America, executive members of Yeshiva College, Orthodox Jewish Congregations of America and Canada, and treasurer of the United Charities Institutions of Jerusalem.


text:
PNEUMOVAX 23 - streptococcus pneumoniae type 1 polysaccharide antigen, a, streptococcus pneumoniae type 2 polysaccharide antigen, a, streptococcus pneumoniae type 3 polysaccharide antigen, a, streptococcus pneumoniae type 4 polysaccharide antigen, a, streptococcus pneumoniae type 5 polysaccharide antigen, a, streptococcus pneumoniae type 6b polysaccharide antigen, a, streptococcus pneumoniae type 7f polysaccharide antigen, a, streptococcus pneumoniae type 8 polysaccharide antigen, a, streptococcus pneumoniae type 9n polysaccharide antigen, a, streptococcus pneumoniae type 9v polysaccharide antigen, a, streptococcus pneumoniae type 10a polysaccharide antigen, a, streptococcus pneumoniae type 11a polysaccharide antigen, a, streptococcus pneumoniae type 12f polysaccharide antigen, a, streptococcus pneumoniae type 14 polysaccharide antigen, a, streptococcus pneumoniae type 15b polysaccharide antigen, a, streptococcus pneumoniae type 17f polysaccharide antigen, a, streptococcus pneumoniae type 18c polysaccharide antigen, a, streptococcus pneumoniae type 19f polysaccharide antigen, a, streptococcus pneumoniae type 19a polysaccharide antigen, a, streptococcus pneumoniae type 20 polysaccharide antigen, a, streptococcus pneumoniae type 22f polysaccharide antigen, a, streptococcus pneumoniae type 23f polysaccharide antigen, a and streptococcus pneumoniae type 33f polysaccharide antigen, a injection, solution
Merck & Co., Inc.
PNEUMOVAX1 23 (Pneumococcal Vaccine Polyvalent) is a sterile, liquid vaccine for intramuscular or subcutaneous injection. It consists of a mixture of highly purified capsular polysaccharides from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae, including the six serotypes that most frequently cause invasive drug-resistant pneumococcal infections among children and adults in the United States.{1} (See Table 1.) The 23-valent vaccine accounts for at least 90% of pneumococcal blood isolates and at least 85% of all pneumococcal isolates from sites which are generally sterile as determined by ongoing surveillance of U.S. data.{2}
PNEUMOVAX 23 is manufactured according to methods developed by the Merck Research Laboratories. Each 0.5 mL dose of vaccine contains 25 μg of each polysaccharide type in isotonic saline solution containing 0.25% phenol as a preservative.
|Pneumococcal Types
Registered trademark of MERCK & CO., Inc. COPYRIGHT © 1986, 2007 MERCK & CO., Inc. All rights reserved
Pneumococcal infection is a leading cause of death throughout the world{3} and a major cause of pneumonia, bacteremia, meningitis, and otitis media.
Strains of drug-resistant S. pneumoniae have become increasingly common in the United States and in other parts of the world. In some areas as many as 35% of pneumococcal isolates have been reported to be resistant to penicillin. Many penicillin-resistant pneumococci are also resistant to other antimicrobial drugs (e.g., erythromycin, trimethoprim-sulfamethoxazole and extended-spectrum cephalosporins), therefore emphasizing the importance of vaccine prophylaxis against pneumococcal disease.
Pneumococcal infection causes approximately 40,000 deaths annually in the United States.{1}
At least 500,000 cases of pneumococcal pneumonia are estimated to occur annually in the United States; S. pneumoniae accounts for approximately 25-35% of cases of community-acquired bacterial pneumonia in persons who require hospitalization.{1}
Pneumococcal disease accounts for an estimated 50,000 cases of pneumococcal bacteremia annually in the United States. Some studies suggest the overall annual incidence of bacteremia to be approximately 15 to 30 cases/100,000 population with 50 to 83 cases/100,000 for persons 65 years of age and older and 160 cases/100,000 for children less than two years of age.
The incidence of pneumococcal bacteremia is as high as 1% (940 cases/100,000 population) among persons with acquired immunodeficiency syndrome (AIDS).
In the United States, the risk of acquiring bacteremia is lower among whites than among persons in some other racial/ethnic groups (i.e., blacks, Alaskan Natives, and American Indians).
Despite appropriate antimicrobial therapy and intensive medical care, the overall case-fatality rate for pneumococcal bacteremia is 15-20% among adults{4}, and among elderly patients this rate is approximately 30-40%. An overall case-fatality rate of 36% was documented for adult inner-city residents who were hospitalized for pneumococcal bacteremia.{1}
In the United States, pneumococcal disease accounts for an estimated 3,000 cases of meningitis annually. The estimated overall annual incidence of pneumococcal meningitis is approximately 1 to 2 cases per 100,000 population. The incidence of pneumococcal meningitis is highest among children six to 24 months and persons aged ≥ 65 years; rates for blacks are twice as high as those for whites or Hispanics. Recurrent pneumococcal meningitis may occur in patients who have chronic cerebrospinal fluid leakage resulting from congenital lesions, skull fractures, or neurosurgical procedures.{1}
Invasive pneumococcal disease (e.g., bacteremia or meningitis) and pneumonia cause high morbidity and mortality in spite of effective antimicrobial control by antibiotics.{4} These effects of pneumococcal disease appear due to irreversible physiologic damage caused by the bacteria during the first 5 days following onset of illness,{5,6} and occur regardless of antimicrobial therapy.{5,7} Vaccination offers an effective means of further reducing the mortality and morbidity of this disease.
In addition to the very young and persons 65 years of age or older, patients with certain chronic conditions are at increased risk of developing pneumococcal infection and severe pneumococcal illness.
Patients with chronic cardiovascular diseases (e.g., congestive heart failure or cardiomyopathy), chronic pulmonary diseases (e.g., chronic obstructive pulmonary disease or emphysema), or chronic liver diseases (e.g., cirrhosis), diabetes mellitus, alcoholism or asthma (when it occurs with chronic bronchitis, emphysema, or long-term use of systemic corticosteroids) have an increased risk of pneumococcal disease. In adults, this population is generally immunocompetent.{1}
Patients at high risk are those who have a decreased responsiveness to polysaccharide antigen or an increased rate of decline in serum antibody concentrations as a result of: immunosuppressive conditions (congenital immunodeficiency, human immunodeficiency virus [HIV] infection, leukemia, lymphoma, multiple myeloma, Hodgkin's disease, or generalized malignancy); organ or bone marrow transplantation; therapy with alkylating agents, antimetabolites, or systemic corticosteroids; chronic renal failure or nephrotic syndrome.{1,8}
Patients at the highest risk of pneumococcal infection are those with functional or anatomic asplenia (e.g., sickle cell disease{9} or splenectomy), because this condition leads to reduced clearance of encapsulated bacteria from the bloodstream. Children who have sickle cell disease or have had a splenectomy are at increased risk for fulminant pneumococcal sepsis associated with high mortality.{1}
It has been established that the purified pneumococcal capsular polysaccharides induce antibody production and that such antibody is effective in preventing pneumococcal disease.{6,10} Clinical studies have demonstrated the immunogenicity of each of the 23 capsular types when tested in polyvalent vaccines.
Studies with 12-, 14-, and 23-valent pneumococcal vaccines in children two years of age and older and in adults of all ages showed immunogenic responses.{10,11-14} Protective capsular type-specific antibody levels generally develop by the third week following vaccination.{13}
Bacterial capsular polysaccharides induce antibodies primarily by T-cell-independent mechanisms. Therefore, antibody response to most pneumococcal capsular types is generally poor or inconsistent in children aged < 2 years whose immune systems are immature.{1}
The protective efficacy of pneumococcal vaccines containing 6 or 12 capsular polysaccharides was investigated in two controlled studies of young, healthy gold miners in South Africa, in whom there was a high attack rate for pneumococcal pneumonia and bacteremia.{13} Capsular type-specific attack rates for pneumococcal pneumonia were observed for the period from 2 weeks through about 1 year after vaccination. Protective efficacy was 76% and 92%, respectively, in the two studies for the capsular types represented.
In similar studies carried out by Dr. R. Austrian and associates,{15} using similar pneumococcal vaccines prepared for the National Institute of Allergy and Infectious Diseases, the reduction in pneumonia caused by the capsular types contained in the vaccines was 79%. Reduction in type-specific pneumococcal bacteremia was 82%.
A prospective study in France found pneumococcal vaccine to be 77% effective in reducing the incidence of pneumonia among nursing home residents.{16}
In the United States, two postlicensure randomized controlled trials, in the elderly or patients with chronic medical conditions who received a multivalent polysaccharide vaccine, did not support the efficacy of the vaccine for nonbacteremic pneumonia.{17,18} However, these studies may have lacked sufficient statistical power to detect a difference in the incidence of laboratory-confirmed, nonbacteremic pneumococcal pneumonia between the vaccinated and nonvaccinated study groups.{1,19}
A meta-analysis of nine randomized controlled trials of pneumococcal vaccine concluded that pneumococcal vaccine is efficacious in reducing the frequency of nonbacteremic pneumococcal pneumonia among adults in low-risk groups but not in high-risk groups.{20} These studies may have been limited because of the lack of specific and sensitive diagnostic tests for nonbacteremic pneumococcal pneumonia. The pneumococcal polysaccharide vaccine is not effective for the prevention of common upper respiratory disease in children.{1}
More recently, multiple case-control studies have shown pneumococcal vaccine is effective in the prevention of serious pneumococcal disease, with point estimates of efficacy ranging from 56% to 81% in immunocompetent persons.{1,21-26}
Only one case-control study did not document effectiveness against bacteremic disease possibly due to study limitations, including small sample size and incomplete ascertainment of vaccination status in patients.{27} In addition, case-patients and persons who served as controls may not have been comparable regarding the severity of their underlying medical conditions, potentially creating a biased underestimate of vaccine effectiveness.{1,19}
A serotype prevalence study, based on the Centers for Disease Control pneumococcal surveillance system, demonstrated 57% overall protective effectiveness against invasive infections caused by serotypes included in the vaccine in persons ≥ 6 years of age, 65-84% effectiveness among specific patient groups (e.g., persons with diabetes mellitus, coronary vascular disease, congestive heart failure, chronic pulmonary disease, and anatomic asplenia) and 75% effectiveness in immunocompetent persons aged ≥ 65 years of age. Vaccine effectiveness could not be confirmed for certain groups of immunocompromised patients; however, the study could not recruit sufficient numbers of unvaccinated patients from each disease group.
In an earlier study, vaccinated children and young adults aged 2 to 25 years who had sickle cell disease, congenital asplenia, or undergone a splenectomy experienced significantly less bacteremic pneumococcal disease than patients who were not vaccinated.{1,28}
Following pneumococcal vaccination, serotype-specific antibody levels decline after 5-10 years.{1} A more rapid decline in antibody levels may occur in some groups (e.g., children).{1} Limited published data suggest that antibody levels may decline in the elderly > 60 years of age.{29,30}
The Advisory Committee on Immunization Practices (ACIP) states that these findings indicate that revaccination may be needed to provide continued protection.{1} (See INDICATIONS AND USAGE, Revaccination.)
The results from one epidemiologic study suggest that vaccination may provide protection for at least nine years after receipt of the initial dose.{22} Decreasing estimates of effectiveness with increasing interval since vaccination, particularly among the very elderly (persons aged ≥ 85 years) have been reported.{23}
PNEUMOVAX 23 is indicated for vaccination against pneumococcal disease caused by those pneumococcal types included in the vaccine. Effectiveness of the vaccine in the prevention of pneumococcal pneumonia and pneumococcal bacteremia has been demonstrated in controlled trials in South Africa, France and in case-control studies.
PNEUMOVAX 23 will not prevent disease caused by capsular types of pneumococcus other than those contained in the vaccine.
Vaccination with PNEUMOVAX 23 is recommended for selected individuals as follows:
The ACIP has vaccine specific recommendations for the prevention of pneumococcal disease. Available from: http://www.cdc.gov/mmwr/PDF/rr/rr4608.pdf{1} and http://www.cdc.gov/vaccines/recs/provisional/downloads/pneumo-Oct-2008-508.pdf{31}
NOTE: The ACIP recommends routine vaccination for immunocompetent persons 65 years of age and older.
Pneumococcal vaccine should be given at least two weeks before elective splenectomy, if possible.
For planning cancer chemotherapy or other immunosuppressive therapy (e.g., for patients with Hodgkin's disease or those who undergo organ or bone marrow transplantation), pneumococcal vaccination should be administered at least two weeks prior to the initiation of immunosuppressive therapy. Vaccination during chemotherapy or radiation therapy should be avoided. Based on literature reports, pneumococcal vaccine may be given as early as several months following completion of chemotherapy or radiation therapy for neoplastic disease.{32,33} In Hodgkin's disease, immune response to vaccination may be impaired for two years or longer after intensive chemotherapy (with or without radiation). During the two years following the completion of chemotherapy or other immunosuppressive therapy, antibody responses improve in some patients as the interval between the end of treatment and pneumococcal vaccination increases.{32}
Persons with asymptomatic or symptomatic HIV infection should be vaccinated as soon as possible after their diagnosis is confirmed.
The ACIP states that pneumococcal vaccine may be administered at the same time as influenza vaccine (by separate injection in the other arm) without an increase in side effects or decreased antibody response to either vaccine.{1} In contrast to pneumococcal vaccine, influenza vaccine is recommended annually, for appropriate populations.{34}
The ACIP has recommendations for revaccination against pneumococcal disease in persons at high risk who were previously vaccinated with PNEUMOVAX 23 or the pneumococcal conjugate vaccine.{1,31,35}
If PNEUMOVAX 23 is used for revaccination, a single 0.5 mL dose is administered subcutaneously or intramuscularly.
Hypersensitivity to any component of the vaccine. Epinephrine injection (1:1000) must be immediately available should an acute anaphylactoid reaction occur due to any component of the vaccine.
For planning cancer chemotherapy or other immunosuppressive therapy (e.g., for patients with Hodgkin's disease or those who undergo organ or bone marrow transplantation), the timing of the vaccination is critical. (See INDICATIONS AND USAGE, Timing of Vaccination.)
If the vaccine is used in persons receiving immunosuppressive therapy, the expected serum antibody response may not be obtained and potential impairment of future immune responses to pneumococcal antigens may occur.{36} (See INDICATIONS AND USAGE, Timing of Vaccination.)
Intradermal administration may cause severe local reactions.
Caution and appropriate care should be exercised in administering PNEUMOVAX 23 to individuals with severely compromised cardiovascular and/or pulmonary function in whom a systemic reaction would pose a significant risk.
Any febrile respiratory illness or other active infection is reason for delaying use of PNEUMOVAX 23, except when, in the opinion of the physician, withholding the agent entails even greater risk.
In patients who require penicillin (or other antibiotic) prophylaxis against pneumococcal infection, such prophylaxis should not be discontinued after vaccination with PNEUMOVAX 23.
PNEUMOVAX 23 may not be effective in preventing pneumococcal meningitis in patients who have chronic cerebrospinal fluid (CSF) leakage resulting from congenital lesions, skull fractures, or neurosurgical procedures.
Routine revaccination of immunocompetent persons previously vaccinated with a 23-valent vaccine is not recommended. However, revaccination once is recommended for persons aged ≥ 2 years who are at highest risk for serious pneumococcal infections and those likely to have a rapid decline in pneumococcal antibody levels. (See INDICATIONS AND USAGE, Revaccination.)
The health care provider should determine the current health status and previous vaccination history of the vaccinee. (See INDICATIONS AND USAGE, Revaccination.)
The health care provider should question the patient, parent or guardian about reactions to a previous dose of PNEUMOVAX 23 or other pneumococcal vaccine.
The health care provider should inform the patient, parent or guardian of the benefits and risks associated with vaccination. For risks associated with vaccination, see WARNINGS, PRECAUTIONS, and ADVERSE REACTIONS. Patients, parents, or guardians should be told that vaccination with PNEUMOVAX 23 may not offer 100% protection from pneumococcal infection.
Patients, parents and guardians should be instructed to report any serious adverse reactions to their health care provider who in turn should report such events to the vaccine manufacturer or the U.S. Department of Health and Human Services through the Vaccine Adverse Event Reporting System (VAERS), 1-800-822-7967.{37}
Animal reproduction studies have not been conducted with PNEUMOVAX 23. It is also not known whether PNEUMOVAX 23 can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. PNEUMOVAX 23 should be given to a pregnant woman only if clearly needed.
It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when PNEUMOVAX 23 is administered to a nursing woman.
PNEUMOVAX 23 is not indicated in children less than 2 years of age. Safety and effectiveness in children below the age of 2 years have not been established. Children in this age group respond poorly to the capsular types contained in this polysaccharide vaccine. (See CLINICAL PHARMACOLOGY, Immunogenicity.)
Persons 65 years of age or older were enrolled in several clinical studies of PNEUMOVAX 23 that were conducted pre- and post-licensure. In the largest of these studies, the safety of PNEUMOVAX 23 in adults 65 years of age and older was compared to the safety of PNEUMOVAX 23 in adults 50 to 64 years of age. Of 1007 subjects enrolled in this study, 433 subjects were 65 to 74 years of age, and 195 subjects were 75 years of age or older. No overall difference in safety was observed between these subjects and younger subjects. However, since elderly individuals may not tolerate medical interventions as well as younger individuals, a higher frequency and/or a greater severity of reactions in some older individuals cannot be ruled out.
The most common adverse experiences reported with PNEUMOVAX 23 in clinical trials were:
Local reaction at injection site including soreness, erythema, warmth, swelling and induration
Fever ≤102°F
Other adverse experiences reported in clinical trials and/or in post-marketing experience with PNEUMOVAX 23 include:
General disorders and administration site conditions
Fever (> 102°F)
Decreased limb mobility
Peripheral edema in the injected extremity
Digestive System
Thrombocytopenia in patients with stabilized idiopathic thrombocytopenic purpura{38}
Hemolytic anemia in patients who have had other hematologic disorders
Hypersensitivity reactions including
Anaphylactoid reactions
Serum Sickness
Angioneurotic edema
Musculoskeletal System
Nervous System
Guillain-Barré syndrome
Febrile convulsion
Increased serum C-reactive protein
In post-marketing experience, injection site cellulitis-like reactions were reported rarely; between 1989 and 2002, when approximately 43 million doses were distributed, the annual reporting rate was <2/100,000 doses. These cellulitis-like reactions occurred with initial and repeat vaccination at a median onset time of 2 days after vaccine administration.
Systemic signs and symptoms including fever, leukocytosis and an increase in the laboratory value for serum C-reactive protein may be associated with local reactions.
In a clinical trial, an increased rate of local reactions has been observed with revaccination at 3-5 years following primary vaccination.
For subjects aged ≥65 years, it was reported that the overall injection-site adverse experiences rate was higher following revaccination (79.3%) than following primary vaccination (52.9%). For subjects aged 50-64 years, the reported overall injection-site adverse experiences rate for re-vaccinees and primary vaccinees were similar (79.6% and 72.8% respectively).
In both age groups, re-vaccinees reported a higher rate of a composite endpoint (any of the following: moderate pain, severe pain, and/or large induration at the injection site) than primary vaccinees. Among subjects ≥65 years of age, the composite endpoint was reported by 30.6% and 10.4% of revaccination and primary vaccination subjects, respectively, while among subjects 50-64 years of age, the endpoint was reported by 35.5% and 18.9% respectively. The injection site reactions occurred within the 3 day monitoring period and typically resolved by day 5.
The rate of overall systemic adverse experiences was similar among both primary vaccinees and re-vaccinees within each age group. The rate of vaccine-related systemic adverse experiences was higher following revaccination (33.1%) than following primary vaccination (21.7%) in subjects ≥65 years of age, and was similar following revaccination (37.5%) and primary vaccination (35.5%) in subjects 50-64 years of age. The most common systemic adverse experiences reported after PNEUMOVAX 23 were as follows: asthenia/fatigue, myalgia and headache.
Regardless of age, the observed increase in post vaccination use of analgesics (≤13% in the re-vaccinees and ≤4% in the primary vaccinees) returned to baseline by day 5.
Do not inject intravenously or intradermally.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. PNEUMOVAX 23 is a clear, colorless solution. The vaccine is used directly as supplied. No dilution or reconstitution is necessary. Phenol 0.25% has been added as a preservative.
It is important to use a separate sterile syringe and needle for each individual patient to prevent transmission of infectious agents from one person to another.
Withdraw 0.5 mL from the vial using a sterile needle and syringe free of preservatives, antiseptics, and detergents.
Administer a single 0.5 mL dose of PNEUMOVAX 23 subcutaneously or intramuscularly (preferably in the deltoid muscle or lateral mid-thigh), with appropriate precautions to avoid intravascular administration.
Store unopened and opened vials at 2-8°C (36-46°F). All vaccine must be discarded after the expiration date.
The ACIP states that pneumococcal vaccine may be administered at the same time as influenza vaccine (by separate injection in the other arm) without an increase in side effects or decreased antibody response to either vaccine.{1} In contrast to pneumococcal vaccine, influenza vaccine is recommended annually, for appropriate populations.{35}
No. 4739 — PNEUMOVAX 23 is supplied as one 5-dose vial of liquid vaccine, color coded with a purple cap and stripe on the vial labels and cartons, NDC 0006-4739-00.
No. 4739 — PNEUMOVAX 23 is supplied as one 5-dose vial of liquid vaccine, in a box of 10 five-dose vials, color coded with a purple cap and stripe on the vial labels and cartons, NDC 0006-4739-50.
No. 4943 — PNEUMOVAX 23 is supplied as a single-dose vial of liquid vaccine, in a box of 10 single-dose vials, color coded with a purple cap and stripe on the vial labels and cartons, NDC 0006-4943-00.
Manuf. and Dist. by:
MERCK & CO., INC., Whitehouse Station, NJ 08889, USA
Issued June 2009
Printed in USA
1 Dose Vial (0.5 mL/dose)
Vaccine Polyvalent
Do not use in children less than 2 years of age.
U.S. Govt. Lic. No. 2
Rx only
10 Single-Dose 0.5 mL Vials
Pneumococcal Vaccine Polyvalent
Do not use in children less than 2 years of age.
Each 0.5 mL dose contains 25 mcg of polysaccharide from each pneumococcal capsular type.
Contains phenol 0.25% added as preservative.
Rx only
Manuf. and Dist. by:
5 Dose Vial (0.5 mL/dose)
Vaccine Polyvalent
Do not use in children less than 2 years of age.
U.S. Govt. Lic. No. 2
Rx only
5 Dose Vial
Do not use in children less than 2 years of age.
Each 0.5 mL dose contains 25 mcg of polysaccharide from each pneumococcal capsular type.
Contains phenol 0.25% added as preservative.
Rx only
Manuf. and Dist. by:
pneumococcal vaccine polyvalent injection, solution
|Marketing Information
|Marketing Category
|Application Number or Monograph Citation
|Marketing Start Date
|Marketing End Date
pneumococcal vaccine polyvalent injection, solution
|Marketing Information
|Marketing Category
|Application Number or Monograph Citation
|Marketing Start Date
|Marketing End Date
|Labeler - Merck & Co., Inc. (001317064)
|Merck & Co., Inc.


text:
Gene Therapy in Treating Women With Refractory or Relapsed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Peritoneal Cancer
Recruitment status was: Active, not recruiting
- Full Text View
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
RATIONALE: Gene therapy may make the body build an immune response to kill tumor cells.
PURPOSE: Phase II trial to study the effectiveness of gene therapy in treating women who have refractory or relapsed ovarian epithelial cancer, fallopian tube cancer, or peritoneal cancer.
|Fallopian Tube Cancer Ovarian Cancer Primary Peritoneal Cavity Cancer
|Biological: herpes simplex thymidine kinase Drug: ganciclovir
|Phase 2
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|A Phase II Trial of In Vivo Gene Therapy With the Herpes Simplex Thymidine Kinase for the Treatment of Ovarian Cancer
|Study Start Date:
|June 2000
- Determine the efficacy and safety of in vivo gene therapy with herpes simplex thymidine kinase (HSVtk) vector producer cells (VPC) followed by ganciclovir in women with refractory or relapsed ovarian epithelial adenocarcinoma, fallopian tube cancer, or peritoneal cancer.
- Determine any development of systemic immunity to this regimen or tumor in these patients.
- Determine the toxic effects of intraperitoneal HSVtk VPC in these patients.
OUTLINE: All patients receive an intraperitoneal catheter prior to infusion.
Patients receive herpes simplex thymidine kinase (HSVtk) vector producer cells (VPC) IP over 15-60 minutes on day 0, followed by ganciclovir IV 2 times daily on days 28-41. Treatment repeats for up to 3 courses in patients with stable or responsive disease.
Patients are followed every 3 months for 1 year.
PROJECTED ACCRUAL: A total of 14-20 patients will be accrued for this study within 18-24 months.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Histologically confirmed, refractory or relapsed, ovarian epithelial adenocarcinoma, fallopian tube cancer, or extraovarian peritoneal cancer for which no curative therapy exists
- Must have tissue available from tumor biopsy to grow tumor cells ex vivo
- Must have failed standard therapy with both a platinum agent (cisplatin or carboplatin) and paclitaxel
- Site of disease must be less than 5 cm in greatest diameter
- Evaluable disease by CT scan, physical exam, or laparoscopy
No significant peritoneal fibrosis either from disease or prior surgery
- Surgical lysis of adhesions allowed
- 18 and over
Performance status:
Life expectancy:
- Not specified
- WBC greater than 2,000/mm3
- Absolute neutrophil count at least 1,000/mm3
- Platelet count at least 50,000/mm3
- Hemoglobin at least 8.5 g/dL (without transfusion)
- Bilirubin no greater than 2.0 mg/dL
- SGOT or SGPT no greater than 4 times upper limit of normal (ULN)
- Alkaline phosphatase no greater than 4 times ULN
- Hepatitis B surface antigen test required prior to study if transaminases greater than 2.0 times ULN
- No hepatitis B surface antigen
- Amylase normal
- PT and PTT normal
- Creatinine no greater than 2.0 mg/dL OR
- Creatinine clearance at least 50 mL/min
- No cardiac dysfunction by history and exam
- No ischemic heart disease that may be considered anesthetic or operative risk
- No lung disease that may be considered anesthetic or operative risk
- HIV negative
- Not pregnant or nursing
- No acute viral, bacterial, or fungal infection requiring medication within 14 days prior to study
- No patient with greater than 2 L of ascites at the time of intraperitoneal infusion
- No underlying condition that would preclude compliance
- No allergies to study reagent
Biologic therapy:
- Not specified
- See Disease Characteristics
- No concurrent chemotherapy
Endocrine therapy:
- Not specified
- Not specified
- See Disease Characteristics
- No concurrent high dose vitamin regimens
Please refer to this study by its ClinicalTrials.gov identifier: NCT00005025
|United States, Iowa
|Human Gene Therapy Research Institute
|Des Moines, Iowa, United States, 50309
|Study Chair:
|Charles Joseph Link, MD
|John Stoddard Cancer Center at Iowa Methodist Medical Center
|ClinicalTrials.gov Identifier:
|NCT00005025 History of Changes
|Other Study ID Numbers:
|Study First Received:
|April 6, 2000
|Last Updated:
|November 5, 2013
Keywords provided by National Cancer Institute (NCI):
recurrent ovarian epithelial cancer
fallopian tube cancer
primary peritoneal cavity cancer
Additional relevant MeSH terms:
Ovarian Neoplasms
Fallopian Tube Neoplasms
Peritoneal Neoplasms
Endocrine Gland Neoplasms
Neoplasms by Site
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Fallopian Tube Diseases
Abdominal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Peritoneal Diseases
Antiviral Agents
Anti-Infective Agents
ClinicalTrials.gov processed this record on September 21, 2017


text:
Capricious canine mutant to follow Lion-O...
For a great selection of film, comic and TV action figures and collectibles, check out BigBadToyStore.com, BriansToys.com, ToyWiz.com, PastGenerationToys.com, Urban-Collector.com, MonkeyDepot.com, HobbyLinkJapan.com, and Sekaido.com.
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Coming in December from Icon Heroes, Jackalman is presented in this 6 inch scale resin statue atop a detailed base. Amongst the mutants, Jackalman can be both loyal and traitorous at the same time if it is to his benefit. He is also one of the more humorous and cowardly of the bunch.
- 6 inch scale polyresin statue
- Based on the classic 1985 Thundercats
- Full sculpt cobblestone environment figure base
- Meticulous body sculpt in battle stance
- Stands approximately 7.5" tall with base (Figurine is approximately 5.5" tall and base is approximately 2" tall)*
- Item weight: 1 lb*
*Details are based on estimates
Source: shopiconheroes.com/thjaremistao.html


text:
UNDATED - Governor Nathan Deal has a full calendar this week, and his schedule has him in north Georgia for at least four events.
The governor a stop Tuesday afternoon at Holiday Marina on the shores of Lake Lanier, where he will sign into law new boating legislation for the state. Those new laws were prompted by deadly accidents on Lanier last summer.
The governor and first lady will be at a dinner in Gainesville Thursday night for My Sister's Place.
Then on Friday morning, Governor Deal takes part in a ribbon cutting for the city of Demorest's new streetscape project. He wraps up the day making comments at the inauguration of Dr. Bonita Jacobs, who becomes president at the newly consolidated University of North Georgia.


text:
The Regnum Christi Movement offers its members some guidelines of a gospel-based spirituality as an ideal of Christian life. The spiritual path that Regnum Christi members walk mainly consists in knowing, loving, imitating, and proclaiming Christ. This is the path and these are the goals.
Below, we offer some resources that can help nurture the spiritual life of Movement members and of any Christian.
Daily Prayer 2013-04-15
Listen to podcast version here.
Father Daniel Ray, LC
John 6: 22-29
After Jesus
had fed the five thousand men, his disciples saw
him walking on the sea. The next day, the crowd
that remained across the sea saw that there had
been only one boat there, and that Jesus had
not gone along with his disciples in the boat, but
only his disciples had left. Other boats came from
Tiberias near the place where they had eaten the
bread when the Lord gave thanks. When the crowd saw
that neither Jesus nor his disciples were there, they
themselves got into boats and came to Capernaum looking
for Jesus. And when they found him across the sea
they said to him, "Rabbi, when did you get
here?" Jesus answered them and said, "Amen, amen, I
say to you, you are looking for me not because
you saw signs but because you ate the loaves
and were filled. Do not work for food that
perishes but for the food that endures for eternal life,
which the Son of Man will give you. For
on him the Father, God, has set his seal." So
they said to him, "What can we do to
accomplish the works of God?" Jesus answered and said
to them, "This is the work of God, that you
believe in the one he sent."
Introductory Prayer:
Lord, I believe that you are present here
and now as I turn to you in prayer. I
trust and have confidence in your desire to give
me every grace I need to receive today. Thank you
for your love, thank you for your immense generosity
toward me. I give you my life and my love
in return.
Petition: Lord, increase my faith.
1. Food of
Eternal Life: Some television evangelists preach a "Gospel of
Prosperity," promising financial and health benefits or general well-being
for those who follow Christ in their church. "Good things
will come your way!" they say. While these earthly
things are good, Christ shows us that his greatest
gifts are not the "loaves that fill," but the grace
and eternal life that can be ours through faith.
Faith is both our offering to God and his
gift to us. It opens our heart to receive the
gift that never perishes: eternal life.
2. No Complacency
in Faith: Christ didn't stay with the crowds, but
rather he crossed over to Capernaum. The crowds, still
full with the bread of the miracle of the loaves,
had to figure out where Christ went, get in
their boats, and find him. When Christ seems to have
moved on us, we need to get into our
boat and row—to look for him, to seek him in
prayer, to be renewed in his sacraments. He wants
us to follow him pro-actively, not passively sitting on
the shore with our boat in dry-dock. We need
to shove off into the waters of prayer and row.
3. What Must We Do? "This is the work of
God…." Our belief (faith) in the one the Father
sent is the result of both God's work in our
lives and our work to use and make that
gift of faith grow. Above all, faith is God's gift
to us. But it is a gift that grows
only when we exercise it, use it, and ask for
more. Just as a runner must run more to
be a better runner, to believe more we need to
believe more. Only then is our heart open to
receive the gift of greater faith.
Conversation with
Christ: Lord, I don't want to settle for seeking
only the "loaves that fill," but the joy and salvation
that comes from believing in you. "I believe; help
my unbelief!" (Mark 9:24). Show me what I must
do to follow you. Make your path clear to me,
and give me the strength to follow it.
Resolution: When faced with any difficulty, obstacle, or frustration
today, I will exercise my faith in God and
seek to do his will.
The daily meditation is a service of Regnum Christi that offers people a Gospel reflection through e-mail. You can view the weekly meditation on this link or listen the podcast version here.
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You're more than welcome to Edit the info or Upload a manga chapter for share. You can also keep track this manga by subscribe the RSS feed or Bookmark it.
|Kiriga Yuki
|Kiriga Yuki
|Comedy, Fantasy, Romance, Shoujo, Supernatural
From Aerandria:
The story begins from the moment a young devil boy transfers to an Academy for angels located deep inside the forest. He was tasked to clean out the monsters in a nearby forest but after successfully doing so, the angels asked him to become the Academy's Knight to prevent a 'great catastrophe!' Sounds great! But, wait... a devil who's a Knight in an Academy for angels?!


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1 pm plc ("1pm" or the "Company")
Trading update and appointment to the board
12 February 2007
1pm, the AIM quoted leasing company specialising in small business finance,
announces today a trading update and the appointment of Mike Johnson as non-
executive chairman of 1pm.
Trading Update
Following flotation, a wide ranging and detailed business review was embarked
upon which led to an examination of every element of the operation necessary to
take the company forward in the most efficient way. As part of this process,
the Company visited a large number of brokers who were keen to refer business to
1pm; consequently there is significant demand for the Company's services.
However, as is often the case when dealing with large financial institutions, it
has taken more time to arrange additional borrowing facilities to meet this
demand than originally anticipated. As a result, revenues and profits will be
lower than market expectations in the current financial year. The Directors are
confident that new facilities will be put in place and that new business levels
will rise significantly during 2007.
The first new facility that 1pm has secured is with Siemens Financial Services
block discounting division. This facility is of £0.5m. The Company is in
process of securing new facilities with other lending banks and will keep the
market informed of progress.
Andrew Dearden, Block Discounting Manager, Siemens Financial Services, said,
"1pm is an extremely well run and professional outfit with some excellent
customers. They are exactly the type of service orientated organisation we want
to be associated with and we look forward to cementing the relationship over the
coming months and years. "
Appointment of Mike Johnson as Non-Executive Chairman
The Company is also delighted to welcome Michael Richard Johnson, aged 63, as
Non-Executive Chairman to the board of 1pm. Mr Johnson was appointed as Non-
Executive Chairman to the board on Friday 9 February 2007. Mike, a successful
entrepreneur with over 30 years' experience in the asset finance industry, has
been brought in to help accelerate the growth of the business. His appointment
will greatly strengthen the management team of 1pm and represents a major coup
for the company.
Mike, was managing director and founder of Suffolk Street Group plc, and was
responsible for creating its small ticket leasing vehicle Equitable Asset
Finance and ultimately negotiating the group's sale to First Sierra Finance of
Houston Texas. He then developed Haydock Asset Finance for the Haydock Finance
Group before co-founding One World Leasing, where he was Executive Chairman,
spearheading the Group's entry strategy in the small ticket market place.
Mr. Johnson was previously a director of both One World Leasing SPV Limited and
One World Leasing Limited.
Mike replaces Steve Grey as Chairman of the company, but Steve will remain on
the Board as a non-executive director, where he continues to provide the benefit
of his many years' experience at board level for Abbey Business and GE Capital.
Mike Johnson has confirmed that there are no further disclosures required under
Schedule 2 paragraph (g) of the AIM Rules.
Contact details:
For further information contact:
1pm plc 08707 397 397
John Stickley
SVS Securities plc 020 7638 5600
Ian Callaway
Peter Manfield
ARM Corporate Finance Limited 020 7512 0191
Nick Harriss
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BarryBasics worn during rehab in Cleveland Ohio
"Thank God someone created BarryBasics. My daughter wore BarryBasics following major surgery on both arms and one leg. The snaps made it possible for her to wear clothes that let the nurses do what they had to do -- and kept my daughter covered and warm. She could not have doner her rehabilitation without these clothes. THANK YOU BarryBasics!"
Marianne, Cleveland, Ohio


text:
Greetings from the (corn) field! The Air Resources Laboratory is collaborating with the U.S. Environmental Protection Agency and North Carolina State University in a 3-year project to measure and model ammonia fluxes in forest and agricultural lands. L-R: Mary Hicks, John T. Walker, Lauren Elich, Tilden Meyers, R. Laureen Gunter, and Jesse Bash.
The NOAA Ship Rainier docked at NOAA's Western Regional Center (WRC) and held an Open House for the employees of the WRC campus before heading out to sea. On this unusually blustery and gray Seattle day, only the courageous few braved the elements to show their NOAA pride. The WRC hosts the greatest variety of NOAA programs and the most NOAA employees outside of Washington, D.C.
Beginning its second decade of continuous operations the Marine Optical Buoy (MOBY) was successfully deployed from the University of Hawai'i Research Vessel Ka'imikai-O-Kanaloa (KOK) in Hawaiian waters off Lana'i. L-R: Terence Houlihan, Darryl Peters, Kent Hughes, Eric Stengel, Yong Sung Kim, Mark Yarbrough, Michael Ondrusek, and Michael Feinholz.
Greetings from NOAA Fisheries Northwest Region.This photo was taken at the first Open Rivers Initiative dam removal project, on the Calapooia River, Oregon. This dam removal, coupled with another downstream, will open up 50 miles of newly accessible salmon and steelhead habitat. L-R: Melissa Jundt, Micheal Tehan, Mike Crouse, Barry Thom, Christy Fellas, and Ben Meyer.
Greetings from the San Joaquin Valley of California! The National Weather Service Office in Hanford provides forecasts, advisories, watches and warnings for a large and geographically diverse area of interior Central California. L-R: Chris Stachelski, Steve Mendenhall, James Brotherton, Paul Jones, Kevin Durfee, and Jim Knutson.
Greetings from Cameroon, West Africa! During the week of September 3-7, 2007, the NOS Office of Response and Restoration sent a member to Douala, Cameroon, to co-teach a class on Incident Command System with the U.S. Coast Guard to 30 students from the governments of Cameroon, Equatorial Guinea, and Gabon. Students are shown with instructor Mark Dix of OR&R and other instructors.
The National Data Buoy Center commemorates NOAA's 200th celebration with a catfish fry attended by NDBC and its technical services contractor, Science Applications International Corporation. Led by NDBC Director Dr. Paul Moersdorf (2nd from R) and SAIC's Program Manager Ted Neville (t3rd from L) over 100 employees, spouses and children attended and enjoyed a beautiful afternoon.
Greetings from the NOAA Air Resources Laboratory, Special Operations and Research Division, Desert Rock Meteorological Observatory, which provides meteorological services and support to the NNSA Nevada Test Site. L-R: Marc Pitchford, Karen Balecha, Rick Lantrip, Don Kim, Paul Rogers, Ray Dennis, Darryl Randerson, Don Bullard, Phil Abbott, Kip Smith, Ogie Olanday, and James Wood.
Managers from the Weather Service Offices in Micronesia gathered on Guam for a week-long meeting at WFO Guam to discuss regional issues among the offices. L-R: Johannes Berdon (WSO Chuuk OIC), Maria Ngemaes (WSO Koror MIC), David Aranug (WSO Yap MIC), Chip Guard (WFO Guam WCM), Genevieve Miller (WFO Guam MIC), Eden Skilling (WSO Pohnpei OIC), and Reginald White (WSO Majuro MIC).
Participants celebrating the launch of a tsunami buoy in the Indian Ocean took time to commemorate NOAA's 200th celebration on the deck of the Indonesian R/V Baruna Jaya III before it left Jakarta in mid-September with the buoy and four NOAA climate buoys on board.
The scientists and crew of the NOAA Ship OSCAR DYSON crossed the Arctic Circle during the Bering-Aleutian Salmon International Survey in the Chukchi Sea and Eastern Bering Sea Shelf. To celebrate, everyone got their "Bluenose".
Personnel from the NOAA Marine Protected Area (MPA) Center visit the MPA located at the center of the Monterey Day coastline, the Elkhorn Slough National Estuarine Research Reserve. L-R: Charlie Wahle, Lauren Wenzel, Joe Uravitch, Kirti Datla, Mimi D'Iorio, Kara Meckley, Lisa Wooninck, Mike O'Farrell, BJ Atanasio, Alex Choe.
NOAA/NMFS staff members of the SEFSC Engineering Laboratory located in the John C. Stennis Space Center, MS. This laboratory is the oldest tenant agency located at the NASA Stennis facility. L-R: Lee Howard, Walt Gandy (Chief), Rex Herron, Ken Wilkinson, Nelson May, Woody Nero, Charles Thompson, Rebecca Spiker, Ian McCoy, Jeneane Davis, Travis Burke, and Donna Spiers.
Greetings from NOAA's National Weather Service office in Lincoln, Illinois! We have been serving a population of approximately 1.6 million people across central and southeast Illinois for the last 12 years. The WFO contributed to the local balloon festival by launching its routine evening balloon and radiosonde which was cheered on by family members and spectators along a nearby highway.
The habitat and marine chemistry section of Auke Bay Laboratories, Alaska Science Center (NOAA) is collaborating with Norwegian researchers in the study of polar cod. The experiment is in Ny lesund, Svalbard Islands, the fourth northernmost permanently inhabited location in the world. L-R: Arve Kristian, Mark Carls (kneeling) Woytek Moskal, Cedric Couret, and Jasmine Nahrgang.
200th Celebration Greetings from the Emerald Isle of Kodiak, Alaska! A group of severely wounded U.S. veterans from the Iraq war and Afghanistan conflict were invited to Kodiak as part of the Wounded Warrior Project's Kodiak Outdoors Program. NOAA personnel and veterans Ryan Pavlu(under NOAA), Brian Neumann, Dan Barnes, and Kevin Pannell (kneeling) and Tom Carpenter (far right standing.)
Greetings from the NOAA Knoll in Seattle, Washington! The NOAA Fisheries Office of Law Enforcement (OLE) is dedicated primarily to the enforcement of laws that protect our Nation's living marine resources. Administrative personnel of OLE offices from all over the country met in Seattle to review procedures and policies.
employees from WFO Fairbanks and NOAA/NESDIS CDAS (Command and Data Acquisition Station) staffed a booth at the Tanana Valley State Fair. A wide ariety of NOAA information was provided to fairgoers including NOAA Weather Radio All Hazards, sustainable fisheries, plus coastal information. L-R: Ed Plumb and Kelly Songster, NWS Fairbanks, and Bonny Pagel, NESDIS Fairbanks.
To commemorate NOAA's 200th celebration, National Weather Service employees and families from the Nebraska Weather Forecasting Offices in Hastings and North Platte participated in a friendly game of softball. It was hard fought and close but in the end North Platte took home the trophy.
Employees from NOAA's National Ocean Service, National Marine Fisheries Service, National Weather Service, National Estuarine Research Reserve System, and National Sea Grant College Program teamed up to feature "One NOAA" at the annual North Carolina Seafood Festival in Morehead City.
NOAA Fisheries Service's Northeast Regional Office hosted a three day public event with the Gloucester Maritime Heritage Center celebrating Gloucester's maritime heritage and NOAA's 200th. L-R top: Mark Kurlansky author of "Cod"; Jill Ortiz, Kathie Ciarametaro, Marcy Scott: L-R bottom: Grandson of Susan Johnson, Tim Keeney giving award to Capt. Arthur Wardwell, NOAA Corps (ret.)100
Scientists from NCCOS' Center for Coastal Monitoring and Assessment, Office of Coast Survey, and NOAA's Great Lakes Environmental Research Laboratory collect zebra mussels attached to rocks in Lake Erie for NCCOS' Mussel Watch Program. L-R: Cliff Cosgrove and Dr. Gunnar Lauenstein with Andrew Yagiela on the boat.
The 2007 Humboldt Bay Maritime Expo was held on Woodley Island in Eureka. Thousands of locals and visitors came out for a day of education and fun. The National Weather Service, National Ocean Service, National Marine Fisheries Service, and Sea Grant all participated as part of "One NOAA". L-R: Gerry Wheaton, Jeffrey Lewitsky, Rick Rodgers, Susan Schlosser, and Debbie Richie.
The Knauss Fellows spent a day in the refuge removing invasive species and learning different aspects of the management of Haystack Rock Unit of the Oregon Islands National Wildlife Refuge.
A warm NOAA Teacher at Sea greeting from a variety of NOAA ships! Twenty-five teachers were sent to sea to work side-by-side with NOAA scientists on cutting- edge research. The teachers were then able to bring what they learned back to their classrooms to share with their students. Since its inception in 1990, the program has introduced over 500 teachers to the ocean science on NOAA ships.
The Flower Garden Banks National Marine Sanctuary hosted an educator workshop called "Down Under, Out Yonder." Participants were introduced to the biology and ecology of coral reefs through a series of presentations and activities for two days on land, then headed out to the sanctuary for three days of diving.
Greetings from the National Weather Service in Great Falls, Montana! The National Weather Service in Great Falls, Montana is home to some of the nation's most extreme weather. Lowest temp in continental U.S.-70F at Rogers Pass 1954; greatest 24-hour temperature change of 103 degrees F in Loma from -49 to 54 on 01/14-15/1972. Also (not a record) 143mph gust at Miller Colony on 2/21/2002.
A celebration greetings from the Inland Northwest! A celebration at NOAA's National Weather Service Forecast Office in Spokane attracted 400 visitors. L-R back: Dwight Williams, Ron Miller, Bob Tobin, Steve Bodnar, and Kerry Jones; Middle: Mike Fries, Jeremy Wolf, Vern Ballard, Royce Fontenot, Greg Koch, and Todd Carter. Front: Laurie Nisbet, Chrisha Layh, and Robin Fox.
An award ceremony for Doug Hollier, National Weather Service volunteer cooperative weather observer. Doug won the prestigious Thomas Jefferson Award, given for unusual and outstanding achievements in the field of meteorological observations. L-R: Jimmy Nunn, Roger Erickson, Andy Patrick, Todd Mogged of NWS Lake Charles; Tim Osborn, NMFS; and Doug Hollier and family.
Greetings from Wellfleet, on Cape Cod Massachusetts! Employees from the Northeast Regional Office of the National Marine Fisheries Service along with HQ staff participated in the 7th Annual Wellfleet OysterFest in October. L-R: Brian Hooker, Paul Perra, Peter Kelliher, David Bean and Carli Bertrand.
Omaha NWS staff hosted a Cooperative Observer Appreciation Celebration and Awards Presentation with more than 40 observers attending. Holding plaquesL-R: Bob Brehm, Raymond, NE (Holm Award); Jim Perley, Little Sioux, IA (20 years); Daryl Obermeyer, Auburn, NE (30 yrs); and Swede Crosier, Oakdale, NE (Stoll Award 50 years.)
NOAA Fisheries personnel participated in the 5th International Fisheries Observer Conference in Victoria, British Columbia. Nearly 300 delegats from 40 countries attended. L-R: NMFS delegation, Todd Dubois, Dr. James Nance, Samantha Brooke, Kevin Busscher, Amy Martins, Dr. Lisa Desfosse, Dr. John Boreman; (seated from left): Mike Tork and Teresa Turk.
Nearly 3,000 educators from around the State of California participated in the participated in the California Science Teachers Association's annual conference. L-R: Claire Fackler, National Marine Sanctuary Program; partner Jessica Neely of PBS-affiliate KQED; Jessica Stock, Cordell Bank NMS; Debra Herring Channel Islands NMS volunteer; and National Park Service partners.
Greetings from National Marine Fisheries Service in New Jersey! New Jersey is home to several thriving commercial fishing ports posting landings of 100 million pounds in 2006. L-R: Alissa Wilson, Anna Macan, Ingo Fleming, Joanne Pellegrino, and Walt Makowski.
Greetings from the Columbia River estuary! Here you see a crew from the Pt. Adams Biological Field Station in Hammond, Oregon at a beach seine sampling site where we investigate juvenile salmon life histories, habitat requirements, and migratory behavior. L-R: Regan McNatt, Rick Nelson, and Curtis Roegner.
Valdez is known as the "Snow Capital of Alaska," where seasonal snowfall can exceed 560 inches, more snow than any sea-level station in the United States. Besides normal NWSFO duties, NWS Valdez office serves as the regional hub for the collection of ship observations via satellite telephone. L-R: Rob Brooks, Gordon May, Debra Elliott, OIC, Wendy Zwickl, and Ron Williams.
A cross-NOAA workshop was held to assess how NOAA uses Global Positioning System (GPS) technologies in operations and research. The 2-day workshop involved 56 participants from across most line offices and many locations. GPS is mainly used within NOAA for navigational purposes but also for tracking radio sondes, storm damage marking, datum referencing, and numerous other uses.
NOAA Ships RONALD H. BROWN and NANCY FOSTER see eye to eye on meeting NOAA's mission! Following their annual Ship Inspection, the two Commanding Officers had a chance to show off their ship handling skills while posing for a photo in Charleston Harbor. Though the two ships share a pier in Charleston, rarely do they see each other due to their demanding schedules.
The Florida Key's National Marine Sanctuary cruise aboard the NOAA Ship NANCY FOSTER yielded an opportunity to assist other programs in need of valuable data. In coordination with NOAA's Undersea Research Center and the Sanctuary, FOSTER worked to create a 1 meter resolution image of the area surrounding the Aquarius Habitat and then supported coral disease studies in the Sanctuary.
200th Greetings from Seattle, Washington!The children of the on-site daycare Little Anchor, their teachers and the parents parade through the NOAA hallways on Halloween and are greeted by many of the employees from Fisheries, Weather Service, Law Enforcement, Workforce Management, NOS, Facilities, Security, etc. It's always an annual treat for everyone.
Cartographers of the Office of Coast Survey's Marine Chart Division, Products Branch gather in Hassler Park to pay tribute to Ferdinand Hassler, first superin tendent of the U.S. Survey of the Coast. L-R: Frank Powers, Paul Spence, Richard Cole (with chart), Patrick Chauvet, Mark Hetrick, Joe Robinson, Mike Gaeta, Holly Johnson, Pramod Singh, John Barber, Dan Morrow, Pearce Hunt, Tangdi Yang.
Greetings from Milford, Connecticut! NOAA Fisheries Aquaculture and Enhancement Division scientists Lisa Milke and James Widman are joined by Kirk Shadle and his students from the Bridgeport Regional Vocational Aquaculture School onboard the vessel Catherine Moore during a cruise to deply an experiment that will analyze overwinter mortality of bay scallops.
Personnel and family members from the National Weather Service Office in Grand Junction, Colorado participate in their annual Adopt a Lake clean up program, a service they have participated in since 1992. They clean two lakes at nearly 10,500 feet. L-R: Doug Crowley, Lisa Pringle, Jim Pringle, Matt Figgs, Melissa and Troy Lindquist: front, Weston, Nolan, Zoe, Madison and McKibben Lindquist.
200th Greetings from NOAA's Climate Prediction Center! The CPC can be traced to 1979 as a growing awareness of climate events and their societal influence (such as El Ni¤o; the severe winter blocking pattern of 1976; and ozone depletion) peaked the interest of the nation.
Close to 100 NOAA's Oceans and Human Health Initiative investigators gathered at the Great Lakes Environmental Research Laboratory field station for their annual meeting. This field station is a renovated 1905 Coast Guard station and the oldest building NOAA operates. Attendees represented the three NOAA OHH Centers and distinguished scholars, external grantees,and advisory panel members
Greetings from Isla Negra, Chile! Participants from the U.S., Chile, Peru, Ecuador, Colombia, Panama, and Mexico attended the First International Workshop on Tools for Marine Protected Area Management Effectiveness. L-R: Sonya Padr¢n, Brad Barr, Anne Walton all of NMSP, Susie Qashu, Elizabeth Taylor, Debra Purce, and Gonzalo Cid of NOS-IPO.
The NOAA Fisheries Laboratory in Panama City, Florida held an open house to commemorate NOAA's 200th Celebration. Personnel from three laboratories of the Southeast Fisheries Science Center participated. Teams from the Galveston, TX Pascagoula, MS laboratories displayed over 100 loggerhead sea turtles and technologies used to prevent sea turtle entrapment in shrimp nets.
Greetings from Navigation Response Team 6, located in Suisun Bay. The team a hydrographic survey around Reserve Fleet vessels. Aging warships and supply vessels are anchored here and maintained by the Dept. of Transportation's Maritime Administration. L-R: Edmund Wernicke, Eric Moore, Laura Pagano.
Greetings from the Desert Southwest! The NOAA National Weather Service Forecast Office in Tucson, AZ, is located on the University of Arizona campus and co- located with USGS offices. L-R: Krist'l Palacio, Chris Rasmussen, Glen Sampson, Glenn Lader, Evelyn Bersack, Erik Pytlak, Norm Phelps, and Chad Kahler.
NOAA NMFS Milford Laboratory and partners teamed up to provide a Teacher Research Experience on board the NOAA R/V Loosanof. L-R back: Ann Guerrera, Krista Bauchman, Valerie Cournoyer, Tracy Bennett, and George Sennefelder; L-R front: Lorrie Martin, Alix Brands, Lawrence Poppe, Ivar Babb, Werner Schreiner, and Capt. Bob Alix. On deck: Dann Blackwood.
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Last Updated:
June 10, 2016


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Meal Mix Gift Basket
If you want to give a charitable gift to less fortunate ones, then surprise them with this coupon of a meal mix gift basket every month for 12 months. Print this and distribute them as gifts and prepare the gift basket that you are going to give every month.
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