text:
Free Shipping on Pet Supplies over $49!
The Deluxe Bark Control Collar is specifically designed with the patented Perfect Bark technology that senses your dog's barking then sends a safe but irritating static correction. It features a progressive correction that increases to the next strongest level if the dog continues to bark, helping to reduce and eliminate the annoyance. The Deluxe Bark Collar is a durable, waterproof collar that contains 10 levels of correction. Includes an adjustable nylon collar, battery (PetSafe RFA-188), operating guide and one year warranty.
Note: The Deluxe Big Dog Collar features a two color LED for good/low battery.
The little dog unit is ideal for dogs up to 55 lb. with a neck size up to 16".
The big dog unit is ideal for dogs 40+ lb. with a neck size up to 28".


text:
6-year Antibody Check After Third Vaccination Against Japanese Encephalitis
This study has been completed.
Medical University of Vienna
Information provided by (Responsible Party):
Herwig Kollaritsch, Medical University of Vienna
ClinicalTrials.gov Identifier:
First received: January 16, 2014
Last updated: February 20, 2015
Last verified: February 2015
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
The purpose of this study is to determine whether there are persisting antibodies against Japanese Encephalitis 6 years after the last vaccination with IXIARO(R) and to adapt or confirm mathematical models accordingly.
|Post Other Specified Vaccination Encephalitis
|Other: Blood draw
|Phase 4
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
|Official Title:
|Neutralizing Antibody Titers 6 Years After the Third Dose of Inactivated Japanese Encephalitis Vaccine and Projected Duration of Protection
Resource links provided by NLM:
MedlinePlus related topics: EncephalitisU.S. FDA Resources
Further study details as provided by Herwig Kollaritsch, Medical University of Vienna:
Primary Outcome Measures:
- Geometric Mean Titer (GMT) for JEV neutralizing antibodies determined by PRNT [ Time Frame: 1.5 years ]
Secondary Outcome Measures:
- Seroprotection Rate (SPR) defined as rate of subjects with JEV neutralizing antibody titers ≥1:10 in a PRNT [ Time Frame: 1.5 years ]
Other Outcome Measures:
- Projected mean duration of protection after a booster dose of JE-VC [ Time Frame: 1.5 years ]
|Study Start Date:
|February 2014
|Study Completion Date:
|June 2014
|Primary Completion Date:
|June 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Single arm
1 blood draw
Other: Blood draw
One-time blood draw
Detailed Description:
Japanese Encephalitis (JE) is a potentially devastating mosquito-borne viral disease. The JE virus (JEV), a Flavivirus, is endemic to many regions in Asia, and while JE is primarily a pediatric disease in the endemic regions, travelers from non-endemic regions to Asia are usually naïve to the virus and may be at risk for contracting JE at any age.
The present study aims to investigate antibody titers at approximately 6 years after the third dose of JE vaccine (JE-VC), in a cohort of participants from an earlier booster dose trial, to strengthen the statistical model of the duration of protection after the booster.
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Subjects who received a booster dose of JE-VC in study IC51-311
- Subjects who are willing to give written informed consent to participate in the trial
Exclusion Criteria:
- Subjects who received a further dose of any Japanese Encephalitis Vaccine since study IC51-311
- Severe immunosuppression (as result of medical conditions or medication) since study IC51-311, such as history of radiation therapy or cytostatic therapy
- simultaneous participation in another clinical study
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02039440
Please refer to this study by its ClinicalTrials.gov identifier: NCT02039440
|Institute for Specific Prophylaxis and Tropical Medicine
|Vienna, Kinderspitalgasse 15, Austria, 1090
Sponsors and Collaborators
Medical University of Vienna
|Principal Investigator:
|Herwig Kollaritsch, Prof. Dr.
|Medizinische Universität Wien, Institut für Spezifische Prophylaxe und Tropenmedizin 1090 Wien, Kinderspitalgasse 15
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 21, 2017
|Responsible Party:
|Herwig Kollaritsch, Ao.Univ.-Prof. Dr.med.univ., Medical University of Vienna
|ClinicalTrials.gov Identifier:
|NCT02039440 History of Changes
|Other Study ID Numbers:
2013-004366-34 ( EudraCT Number )
|Study First Received:
|January 16, 2014
|Last Updated:
|February 20, 2015
Additional relevant MeSH terms:
Encephalitis, Japanese
Encephalomyelitis, Acute Disseminated
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Encephalitis, Arbovirus
Arbovirus Infections
Virus Diseases
Encephalitis, Viral
Central Nervous System Viral Diseases
RNA Virus Infections
Flavivirus Infections
Flaviviridae Infections
Infectious Encephalitis
Central Nervous System Infections
Demyelinating Autoimmune Diseases, CNS
Autoimmune Diseases of the Nervous System
Demyelinating Diseases
Autoimmune Diseases
Immune System Diseases
Immunologic Factors
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on September 21, 2017

subset: commoncrawl


text:
akizawa prevented Japan's destruction - and then he vanished. Six months later, clues lead Saki to the Big Apple in search of her missing friend. Meanwhile, the remaining Selecao are plotting their final move. Some of them would prefer Takizawa dead and out of the way. Some might even be willing to help him achieve his goals. Unfortunately, some are prepared to destroy everything if it means claiming checkmate in Mr. Outside's puzzling game.Overview from themoviedb.org
<> Free subtitles & video converter from freemake company


text:
Friday May 4, 2007 6:29 pm
LawnBott Mows While Saving the Planet
Posted by Sheila Franklin Categories: Household, Misc. Tech, Wireless / WiFi
Spring is upon us and although we like the green stuff coming up, we would rather not have to mow it. Productivity's LawnBott will do that unpleasant chore for you. It will run up to 4 hours or 33,000 square feet on a charge even during a light rain. The gadget will navigate up to 27º slopes or work by remote if you want to manuever it around that gigantic Elm tree in your back yard. Available in four models, owning the eco-friendly bott does not come cheaply, but for the $1,749.00 to $2,899.00 we figure it is worth the investment.
Read More | Productivity via SciFi
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text:
Debt vote no game-changer in Senate
It was once billed as a defining moment that threatened Senate careers: a vote to raise the federal borrowing limit at a time of skyrocketing debt and public fury as red ink spilled out of the Capitol.
But Tuesday's Senate vote revealed that it's not that cut and dry.
Story Continued Below
Republicans who earlier this year hoped Senate Democrats would be forced to carry the water for President Barack Obama and singlehandedly deliver the votes to raise the debt limit were left without much of a political bludgeon after Tuesday's vote. And politically vulnerable Democrats breathed a sigh of relief at the bipartisan 74-26 Senate vote.
In the end, the final deal may have neutralized both parties' ability to seize on the vote to attack vulnerable senators whose fate will determine whether Republicans win back control of the Senate in 2012.
"I don't think it'll have any impact because there's no revenues, there's nothing done to Social Security or Medicare," Senate Majority Leader Harry Reid told POLITICO Tuesday.
Indeed, when everyone from liberals like Sherrod Brown (D-Ohio) — up for reelection next year — to conservatives like Roger Wicker (R-Miss.) — also up for reelection — voted for the same massive debt bill, it's hard to find a distinct campaign advantage for 2012 on this one vote.
But there were clear divisions between Republican and Democratic lawmakers who'll face off in Senate races in Montana, Nevada and Missouri, and it remains to be seen whether the public accepts the deal as a credible budget plan. If it fails to control budget deficits, lawmakers who backed the plan could face outrage from tea party activists already disappointed by the deal. Or if the House-Senate committee created by the new law overhauls entitlements, the left may be furious.
With 23 Democratic Senate seats in cycle, compared to just 10 for the GOP, Republicans believe that the public's anger with Washington will hurt Democrats far more — while Democrats believe that the GOP will be blamed for causing an ugly fight that took the economy to the brink.
Still, vulnerable Democratic senators, particularly from red states, believe voters won't punish them for backing a bipartisan plan aimed at slashing budget deficits — especially a measure supported by Republican leaders of Congress.
"Who voted against it?" asked Florida Sen. Bill Nelson, a Democrat whose seat is targeted in 2012. "The extreme left, extreme right. Florida is not extreme in its politics."
Texas Sen. John Cornyn, chairman of the National Republican Senatorial Committee, which is charged with winning back the Senate majority next year, also voted for the plan. He said the real defining issue in 2012 will be over the strength of the economy under Obama, and he said voters would clearly see where the parties stand when Republicans push for a constitutional balanced-budget amendment, a proposal most Democrats oppose.


text:
|12 Mar 2012
Windows 7 Ultimate 64-bit
Anyone still playing old games?
Even though there's a lot of new games today, which look better, there's still something about old games (Diablo II, Star Wars Empire at War, Galactic Battlegrounds,etc.) that makes me want to play them. No, not because I have played them before and I have memories of them, (I have only played some,) there's that charm within those games...
Anyone here who's like me?
Games I play:
Stronghold Crusader (playing this atm)
Commandos II
Captain Claw
Heroes I
Heroes II
Heroes III
Heroes IV
Red Alert II / Yuri's Revenge
C&C Generals / Zero Hour
Robin Hood (forgot the exact title, plays like Commandos)
Star Wars Galactic Battlegrounds/Clone Campaigns
|My System Specs
|12 Mar 2012
ultimate 64 sp1
wow - those are old games! i still occasionally play company of heroes and medieval 2 against a friend who has an old PC.
they were both released waaaaaaaaaay back in 2006, which is a couple of generations ago in the gaming world...
|My System Specs
|12 Mar 2012
Windows 7 x64 Ultimate
Sometimes I like to indulge in a little gaming nostalgia but it never really lasts too long. and hour or so just for the feeling. But there are way too many new things as it is, just no time to spend on the past
|My System Specs
|12 Mar 2012
Windows 10 64bit
oldest game i kind of play once a while is age of empires and some games from 05 like gta sa and vice city and halo 1 from 02
|My System Specs
|12 Mar 2012
Microsoft Windows 7 Home Premium 64-bit 7600
Anyone still playing old games?
i also really enjoy kid chameleon on the mega drive emulator.
in the early 90's i could complete it in 12 hours and the gaming mags at the time said pros took 18 hours ,
sadly i dont have the time these days to get that kind of hook back.
|My System Specs
|12 Mar 2012
Windows 8.1 Pro
I still play sometimes the old SSI games, AD&D series, so that is showing my age.
|My System Specs
|12 Mar 2012
Windows10 Pro - 64Bit vs.10547
Dungeon Siege and Dungeon Siege/Legends Of Aranna have been on my PC since release in 2000/2002..
Microsoft Game Studios - Dungeon Siege: Legends of Aranna
also the two brilliant Dungeon Siege mods, MageWorld and Lands Of Hyperborea..
Jim Farris, Author and Composer - Home
- can't praise them highly enough..
|My System Specs
|12 Mar 2012
Win7 Pro x64
Still got both my Crusader: No Remorse and Crusader: No Regret discs, although the last time I managed to get them to install and play was in the mid-2000s.
Was watching a friend play the recent Deus Ex game and thought to myself, hey, this is what an updated Crusader game should look like. Albeit with more combat though, Deus Ex seems to be more of a sneaking around thing.
|My System Specs
|12 Mar 2012
Windows 7 Ultimate x64 (XP, 98SE, 95, 3.11, DOS 7.10 on VM) + Ubuntu 10.04 LTS Lucid Lynx
Some of the old games I still play (on DOSBox) when I get some time
Karateka (1984)
Dangerous Dave (1988)
Prince of Persia (1989)
Wolfenstein 3D (1992)
Spear of Destiny (1992)
Halloween Harry (Alien Carnage) (1993)
Bio Menace 1, 2, 3 (1993)
Blackthorne (1994)
|My System Specs
|Thread Tools
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Hello, first time poster looking for help as I can't diagnose my issue after trying numerous things. Currently when I play a game the BSOD happens randomly, I can go a whole day without it, or it can happen frequently. It happens the most when I close or exit a game, then it'll kick to a blue...
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text: Feedback 1 Start 2 Preview 3 Complete 0% We'd love to hear your feedbackThank you for visiting the revamped EAC website.We are interested in your feedback and are keen to find out what you think about it. We would appreciate if you would answer a few questions about your experience today.NOTE: Questions marked with an asterisk * require an answer to be given. What is your overall feeling about the revamped EAC website? * - Select -HateDislikeNeutralLikeLove What is your feedback about? * - Select -Site Design (look and feel, layout, organisation, colours, etc.)Performance (speed, bugs, crashes, etc.)Content (press releases, statements, photos, videos, social media posts)General feedbackOther... What is your feedback about? Other... How do you rate your overall experience? * - Select -PoorBelow averageAverageGoodExcellent Did you find what you were looking for? - None -YesNo What else would you like to share with us? Preview Start Preview Complete Leave this field blank Preview


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Are There Many People That Collect Ruger Revolvers?
View Single Post
November 18, 2012, 03:51 PM
Join Date: November 17, 2012
Posts: 34
Well its easy to think that if your careful all will be well.
I was target shooting with a fired cases box on the ground between my feet to dump my empties and had loaded the 6th chamber the muzzle was pointed down and into the box and I lowered the hammer as usual. It discharged with only the weight of the hammer. The hole in the corner of the box was an inch to the left of my big toe on my right foot. I had shot about a half dozen full cylinders prior to the accident I mean prior to the careless discharge.
No such thing as an accident when a round goes off unintentionally or lands where it shouldn't its always carelessness.
Heed the warning. I would never alter one but I will never again set down on a live round.
The good thing is I still have ten toes and a good reminder when I put the box down for my empties.
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Sally Hansen Just Feet Visible Effect Foot Creme
- 1 reviews See the Breakdown
- Product Info | Add Your Review
Sally Hansen Just Feet Visible Effect Foot Creme Reviews
Nice foot cream, but I don't like the smellThis is a pretty nice foot cream. It moisturizes well, but I really dislike the medicinal-minty fragrance that it has. I'll use it up, but I'll also look for another foot cream to purchase next time. Ingredients: Water, Propylene Glycol, Cetyl Alcohol, Ethylhexyl Palmitate, Dimethicone, Cetearyl Alcohol, Hydrogenated Polyisobutene, Glyceryl Stearate SE, Stearic Acid, Magnesium Aluminum Silic...read moreate, Glyceryl Stearate, PEG-100 Stearate, Aloe Barbadensis Leaf Extract, Shea Butter, Menthol, Peppermint Oil, Tea Tree Leaf Oil, Salicylic Acid, Polysorbate 60, Triethanolamine, Methylparaben, Propylparaben, Imidazolidinyl Urea. — 9 years, 7 months agozernelle | 130 reviews
This review is: Helpful | Not helpful | Inappropriate | 3 of 3 people said helpful
Home » Reviews » Body » Hand, Foot + Nail Treatments » Sally Hansen Just Feet Visible Effect Foot Creme
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Media Center
College Hockey, Inc. welcomes media inquiries and interview requests about the sport. We also maintain a comprehensive list of media contacts at the Division I schools.
Please direct inquiries to:
Nate Ewell
(617) 340-6572
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2016-17 CHI Media Kit (.pdf)
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Facts & Figures
- 30% of all NHL players played college hockey
- 200 NHL Draft picks are playing college hockey in 2016-17
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- 240 former college players currently work in NHL front offices, including 10 general managers and 9 head coaches
- Nine NCAA goaltenders have scored a goal
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College Hockey, Inc. has produced 30-second video and audio public service announcements promoting college hockey that media outlets and institutions are welcome to use.
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Institutions, teams, leagues and media outlets are welcome to use the College Hockey, Inc. logo and link to collegehockeyinc.com. Downloads available below:
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text:
AVENGED SEVENFOLD - Hail To The King Album Streaming At iTunes
August 20, 2013, 4 years ago
AVENGED SEVENFOLD will release their new album, Hail To The King, on August 27th via Warner Bros. Records. An update from the band follows:"We have been waiting to show you all our brand new album, Hail To The King, for far too long. It took us nine months of writing, recording and preparation so that we could put out an album we are all proud of from start to finish. Well I'm excited to announce that the wait is over. We have teamed up with our friends at iTunes to start streaming the full album right now until it's released on August 27th. The stream is high quality and you can listen to the whole album as many times as you'd like. So plug in your best set of headphones and turn it up to 10. Head over there now to listen and pre-order. We hope you enjoy it as much as we do. See you all on the road!"
Listen to Hail To The King here.
Produced by Mike Elizondo, Hail To The King is the follow up to the band's 2010 release, Nightmare, which debuted at #1 on the Billboard Top 200 Album Chart, Hard Rock Chart and Digital Chart.
Hail To The King tracklisting:
'Shepherd Of Fire'
'Hail To The King'
'Doing Time'
'This Means War'
'Crimson Day'
'Coming Home'
'Acid Rain'
'Hail To The King' video:
On August 26th, one day before the release of Hail To The King, Avenged Sevenfold will play a free show for their fans at the Hollywood Palladium. The show is a special thank you to their fans and for fans to celebrate the release of the new album with the band.
Avenged Sevenfold has always been a trailblazing force in fusing the worlds of music and video games. In the past, the band's music and likeness have appeared in the best-selling video game Call of Duty: Black Ops 2 and the band even have their own custom Xbox controller. With Hail To The King being released by on August 27th, Avenged Sevenfold have joined forces with Machinima, the number one global video entertainment network for young males, to bring fans brand new original video content.
From the creative minds of Avenged Sevenfold, and featuring new music from their forthcoming album, Hail To The King is a six-episode animated series, which tells the fictional story of the Death Bat - the band's longtime trademark. Directed by Metalocalypse producer Jon Schnepp, this unique and innovative animated series will air this fall on Machinima's HappyHour channel. Machinima has released the premiere trailer, providing a first-look at the series.


text:
Chevrolet Repair Questions? Ask a Chevy Mechanic for Answers ASAP
HiCustomer Thank you for asking your question on Just Answer.
Can you tell me the Model of truck that you have?
If you are not sure, you can send the Vehicle Identification Number (VIN), and that will tell me.
Thanks, XXXXX
It is a good chance that the problem is the blower motor resistor. Here is the schematic for that system.
But before you try to change the resistor pack, you might want to check the High Speed Relay. If it has a bad connection on one of the contacts, it would have the same symptoms at the resistor pack being bad. Here is a diagram of the relay connector.
If you remove the relay and connect a jumper wire from connectors C1 & B2, then the blower motor should work on the lower speeds IF the resistor pack is OK. Then all you would have to do is replace the High Speed Relay and that should fix it.
If the blower does NOT work on the lower speeds after putting in that jumper, then the resistor pack is probably bad.
Here is a diagram of the components of the system.
You MAY be able to get to these components by removing the insulator panel on the passenger side and the glove box.
I hope this helps. Please let me know if you have more questions.
Take Care, Greg A.


text:
Alabama will soon change the way it taxes motor fuels.
Beginning Oct. 1, gasoline and other fuel will be taxed upon removal from the bulk terminal or import into Alabama, rather than at the distributor level.
The new law will not affect the rate of tax or the purchase price of fuels paid at the pump, according to the Alabama Department of Revenue.
State Revenue Commissioner Julie Magee said the change will streamline tax return reporting and payment requirements.
"The terminal rack is the point at which fuels physically leave a terminal and are delivered into a tank truck, rail car, or other means of transfer." Magee said in a statement. "The only exception will be when fuels are imported into Alabama by ways other than the terminal transfer system or when fuels are blended in Alabama outside the terminal transfer system. In these cases, taxes will be imposed upon import or blending."
Fuel distributors currently file monthly state gasoline or motor fuel tax returns with the Alabama Department of Revenue. With the new law, all fuels, excluding dyed diesel, will be reported on one tax return instead of separate payments for each fuel type.
Fuel suppliers, distributors, importers, terminal operators, exporters, motor fuel transporters, blenders, and aviation fuel purchasers are required to obtain a license to register for the fuel taxes and will be required to file monthly tax returns by the 22nd day of the month following the tax reporting period. A new application and bond form also are to be submitted to the ADOR before licensing.
Also as a result of the new law, fuel distributors will no longer be able to purchase gasoline and diesel fuel tax-free and sell it tax-free to entities exempted by Alabama law, including the U.S. government, city and county boards of education, and private and church schools grades K-12. Tax-exempt entities will have to apply for a fuel tax exemption license to buy fuel tax free.


text:
We are excited to announce the 2013 On The Road tour! On The Road brings the magic of the Summer Camp Music Festival to your town. This spring we will visit multiple cities across the midwest and beyond searching for the best talent the area has to offer. At every stop artists and bands will compete for a chance to perform at the Summer Camp Music Festival on Memorial Day Weekend. The winners are chosen by audience voting and participation. Check out www.facebook.com/summercampontheroadfor info on how to sign your band up for the tour and check us out On The Road….
1/19 : Wooly's * Des Moines, IA
1/25 : The Bluebird * Bloomington, IN
2/01 : Old Rock House * St. Louis, MO
2/22 : The Woodlands Tavern * Columbus, OH
2/23 : The Yacht Club * Iowa City, IA
2/28 : Cervante's Other Side * Denver, CO
3/01 : High Noon Saloon * Madison, WI
3/08 : The Abbey Pub * Chicago, IL
3/09 : The Abbey Pub * Chicago, IL
3/13 : The Blind Pig * Ann Arbor, MI
3/15 : Mojo's * Columbia, MO
3/16 : The Mousetrap * Indianapolis, IN
TBA : Minneapolis, MN
TBA : Boulder, CO


text:
Office of the Commissioner of Sales Tax 8th floor, Vikrikar Bhavan, Mazgaon, Mumbai 400010.
No. Build-Devep/Adm. Relief.06-10 /Adm-8 Mumbai, dated 04-01-2014
Trade Circular No. No. 1T of 2014
Sub: Audit Report to be filed by developers in form 704 for 2012-13.
Background :
I. The Maharashtra Chamber of Housing Industries (MCI-II), Promoters and Builders Association and 10 other petitioners filed Special Leave Petition(SLP) before the Hon. Supreme Court against the order of Hon. Bombay High Court (Writ Petition no. 2022). The Supreme Court has decided these petitions by its common order dt. 26/ 09 /2013. The Supreme Court while upholding the Constitutional validity of the amendment to the definition of Sale of MVAT Act, has clarified that
(i) " The activity of construction undertaken by the developer would be works contract only from the stage when the flat purchaser enters into a contract with the developer and that the value addition to the goods transferred after such agreement can only be made chargeable to tax by the State Government."
(ii)The Court has further stated that, "taxing the sale of goods element in a works contract is permissible even after incorporation of goods provided tax is directed to the value of goods at the time of incorporation and does not purport to tax the transfer of immovable property. The mode of valuation of goods provided in Rule 58(1A) has to be read in the manner that meets this criteria." The Court has directed the State Government of Maharashtra to bring clarity in Rule 58 (1A) as indicated above.
2. In order to give effect to the Supreme Court judgment, it is necessary to amend Rules 58(1) and 58(1A) of the Maharashtra Value Added Tax Rules,2005. The amendment to these rules is under consideration. However, it may take some time to effect the amendment.
3. The prescribed date for filing the report of the audit under section 61 in Form 704 for the financial year 2012-13 is 15th January 2014. In absence of amendment to rule 58(1) and rule 58(1A), it may not be possible to complete the audit of developers.
4. In view of the above, it is administratively decided that if an Audit Report in form 704, pertaining to developer for the period 2012-13, is filed within one month from the due date i.e. on or before 15th February 2014, then penalty u/s 61(2) shall not be imposed.
If any member of the trade has any doubt, he may refer the matter to this office for further clarification.
Commissioner of Sales Tax, Maharashtra State, Mumbai.


text:
Pencil credits from Jerry Bails Who's Who
Story originally featured Captain Flight; renamed Captain Burke in this story; relettered with mostly identical copy; original title "The Isle of Missing Men".
Pencil credit from Who's Who
app. between TERRIFIC COMICS #16 / WONDER BOY #17
Statement of Ownership at bottom. Title listed as Fantastic Illustrated with Illustrated handwrittin.


text:
What are you wearing this weekend? You mean you haven't thought about it at all? Don't sweat it, we picked three great looks for you:
Saturday night: We've shown you lots of drop-dead sexy looks for a night on the town, but sometimes date night is just you, your guy and a giant box of Junior Mints at the movies. If you're heading to the multiplex, might we suggest this comfy look Julianne Hough recently wore? Her Madewell jeans (on sale for $74.99), Matt Bernson wedges and black tee (like this $32 Alternative Apparel one) are casual, but the plunging neckline and sassy moto jacket more than spice up the casual ensemble.
Splash News Online
Sunday brunch: Oxfords, like bold eye makeup, are things that girls seem to love but guys have been less enthusiastic about. So that's why Taylor Swift's outfit is perfect for catching up with the ladies over mimosas on Sunday morning. Plus, all the pieces, including a sheer top (hers is Helmut Lang, but this Mango one is more affordable), flirty skirt and yes, even those brogues (this Forever 21 pair is just $24.80), are so versatile, so you'll get plenty of wear out of them after the bubbly buzz wears off.
Monday morning: Rosario Dawson's Lela Rose print sheath (this similar Ann Taylor dress is $98) and Lana Jewelry hoops are perfectly conservative and work-appropriate, but she adds a little fun via her glossy silver pumps (nab this Colin Stuart pair for $34.99). If you work in a very buttoned-up office, this is the perfect outfit to color outside the lines a little, while still following all the rules to the letter.
Tell us: Which outfit(s) will you try this weekend?
–Alex Apatoff


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Elefantti Long ApronCute, simple and stylish. "Elefantti" meaning elephant in Finnish, is designed by Laina Koskela in 1969 as a result of a design competition by Finlayson and the Institute of Industrial arts. These cunning little elephants melt the hearts of people of all ages.
• Size of long apron is 70 x 85 cm (27.6 x 33.5 in)• Material is 100% cotton• Product color is black/white• Wash at 40C (104F)• Designed in Finland, made in Latvia


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News & Events
05-19-2011 | Sugar Grove
Blacksmith Appointed to CMAP Committee, Chamber Board
Waubonsee Community College Director of Governmental and Multicultural Affairs Lulu Blacksmith was recently appointed to both the Chicago Metropolitan Agency for Planning (CMAP) Citizens' Advisory Committee and the Aurora Regional Chamber of Commerce Board of Directors.
As a member of the Citizens' Advisory Committee, Blacksmith will provide input on proposed regional plans and policies, make recommendations regarding CMAP's Public Participation Plan, and assist in the dissemination of public information and materials.
During her three-year term on the chamber of commerce board, Blacksmith will help business development in the City of Aurora.


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This year at the B&E Invitational we are proud to announce the addition of a Friday night concert! The event will be held at Centre Bernard Taillefer, ARC 1800.
Artists performing at this year's event include L'Entourloop, I Woks Sound & Reggae Mylitis Band and Scratch Bandits Crew! Doors will open at 21:00h.
For more info and tickets go to www.iwokssound.fr/ventilo-fest/


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Yesterday...Lost with Cards 2-1 on the road...teams score a total of 1 run in last two picks...fade me, not doing so good
Posted Record 35-15 after 50 picks in 49 days 70%, going to keep it going with 50 more over 50 days...just getting lucky right now, be careful tailing!!
Today..MLB..Yankees -106
and good luck
i dont think you are lucky ,you are a very good capper imo and we all go thru some losing streaks but you are hitting over 70% most of the time and that is amazing at that .
continue on doing what you have and i always check to see who you are on and i dont mind saying i tail you along with my own picks and you have been just great
Vasquez - I'll go for the ride. Lst couple of starts were ok.


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- All Things to Do
- Attractions & Tours
- Arts & Culture
- Aviation/Hot Air Balloons
- Beer, Wine & Spirits
- Casino & Racing
- Outdoor Recreation
- Religious Shrines & Churches
- Shopping
- Special Offers
From fabulous fall festivals and events to foliage and frightening fun, Bucks County, PA has everything you need to enjoy the changing colors of one of the most picturesque times of year in the countryside. Ideally located 75 miles south of New York City and 25 miles outside of Philadelphia, Bucks County is the perfect destination for a weekend excursion this autumn.
Here are some of the top festivals and events taking place throughout Bucks County this fall. For even more activities, check out our Events Calendar. Note: This information reflects the 2015 season. Check back for 2016 dates.
• New Hope Arts & Crafts Festival, September 26 and 27- Known for its strong arts and crafts community, the quaint river town of New Hope is hosting its 22nd Annual Arts and Crafts Festival this month. Browse the work of talented local artists during this juried show, nosh on delicious food, enjoy live entertainment and more.
• Froehlich's Farm Festival, September 26-October 31 - Celebrate the changing of the leaves, the chill in the air and Halloween at Froehlich's Farm from the end of September throughout October. Enjoy a hayride around the 100-acre farm, get lost in a three-acre corn maze, find the perfect pumpkin from the farm's patch, ride your favorite pony, build a scarecrow, win prizes and warm up with some hot cider!
• Perkasie Fall Festival, October 4 - Enjoy food, artisans, raffles, a scavenger hunt, train rides and live music as they line the streets of the historic downtown of Perkasie. Start with an exciting Color Dash 5k at Bucks County Community College. Kids and the young at heart can have fun at the petting zoo, on pony rides and inflatables at Perkasie Town Center and Menlo Park. Create a scarecrow and bring it for judging! Then sample this year's chili cookoff and pie-baking contest.
• Historic Fallsington Day, October 10 - Visit the "Village that Time Forgot" for a time-honored community event at Historic Fallsington. Journey back in time to Quaker Pennsylvania with the help of colonial and Native American dance performances, crafters and folksingers. Visitors can walk through the 300-year-old town and explore the historic buildings left behind, browse the variety of tables at the old-fashioned flea market, learn how to write with a quill pen, or take in a puppet show from the entertainers that will be present all day. You can also try your luck at winning the highly coveted Fallsington Quilt, a one-of-a-kind handmade quilt that will be on display throughout the day.
• 39th Annual Historic Bristol Day, October 17 - Bristol, Bucks County has a variety of festivals throughout the season and one of the most popular annual festivals is Historic Bristol Day. This free, family-friendly street fair celebrates the town's diversity with a variety of arts and craft vendors, food vendors, entertainers, children's games, a sailing regatta on the Delaware River, a car show, and much more.
• Autumn Alive!, October 17 - The streets of Quakertown celebrate the spirit of the season during the 16th Annual Autumn Alive! This family-friendly event in Upper Bucks County features music, games, prizes, crafts, beer tasting, a pet parade and more. Quick tip: this festival is pet-friendly, so bring your favorite furry friend along for the fun!
• Crafts in the Meadow, October 17-18 - Head over to the Tyler Park Center for the Arts for a weekend-long craft show! Come see the area's best in craftsmanship while enjoying live music, performing arts and refreshments.
• Apple Festival at Peddler's Village, November 7-8 - If you love apples, this is the festival for you! Fall is the perfect time for apple-picking and Peddler's Village celebrates the season all weekend long as they serve up a variety of apple-themed baked goods and treats. Participate in pie-eating contests, enjoy a variety of live entertainment, sample a variety of apple-themed dishes, and browse the work of local artisans lined up along the beautiful cobblestone streets of this 18th-century-style shopping village.
• The Count's Halloween Spooktacular, September 26-November 1 - Bring the little ones and your best Halloween costumes to Sesame Place® for this family-friendly Halloween Tradition. Each year the nation's only amusement park dedicated to the award-winning children's television show Sesame Street® is turned into a not-so-spooky Halloween haven for children of all ages. Come together as a family to find your way through two mazes, enjoy three Halloween shows, take a thrilling hayride with your favorite furry friends and watch an exciting Neighborhood Street Party Halloween Parade.
• Fall at Shady Brook Farm, October 2-October 31 - Take a wagon ride down to the patch to find your pumpkin and enjoy a variety of inflatable attractions, a giant corn maze and more at PumpkinFest! On select evenings, stay for PumpkinFest After Dark, a not-so-scary event for the younger kids, featuring a moonlit corn maze and more. At nightfall on weekends, the friendly farm turns into a den of terror! HorrorFest invites visitors to walk through the Barn of Horror, test your bravery as you trek through the bloody fields of Carnage, ride through the spooky woods on the Hayride of Horror and face aliens head-on at the 3-D Alien Encounter.
• Haunted Halloween Train, October - Hop aboard New Hope & Ivyland Railroad throughout the month of October for their spooky Haunted Halloween Train Rides. Once this terrifying train leaves the safety of the station, there's no telling what horror may lurk among the antique railcars. For a kid-friendly alternative to the terror of these haunted train rides, put on your best Halloween costumes for the Trick or Treat Trains. After your "spooky" ride returns, children can trick-or-treat around the station for some extra special surprises!
• Haunted Bucks County, October - Fall may be known for its beauty, but it is also one of the spookiest times of year and Bucks County has plenty of ways to terrify you. Grab a flashlight and take to the streets with Ghost Tours of New Hope to hear the chilling tales of the area's former residents who may have never left during a lantern-led walk. Explore the darker side of Bucks County during one of the many haunted hayrides in the area such as Valley of Fear's Original Haunted Hayride in the woods behind Phoenix Sport Club, where you can hop off the hayride and test your aim in Zombie Paintball. Also check out Midnight Productions' Sleepy Hollow Hayride. After your bone-chilling ride, enter the House in the Hollow. Only the bravest will travel deep inside to discover the secrets of the manor.
• Embark on a charming and historic adventure of the Bucks County Covered Bridge Driving Tour. Peppered throughout our country back roads, view the twelve beautiful covered bridges and marvel at their incredible authenticity and rich surrounding beauty.
• Experience Bucks County's fall foliage at new heights with the US Hot Air Balloon Team! Drift above miles of breathtaking landscapes as you soar on a picturesque adventure.
• View the gorgeous fall foliage at ground level with a scenic drive along River Road/Route 32. Stop by the eclectic bunch of restaurants and shops sprinkled along the way and enjoy the afternoon taking in the crisp autumn air with wading sounds of the Delaware River in the background.
• Every weekend in October, board the New Hope and Ivyland Railroad for their annual Fall Foliage Excursion Train. All aboard their 1920s vintage passenger coach for a 2 ½ hour journey through the picturesque country side.
• Spend a leisurely fall afternoon strolling through Washington Crossing Historic Park. Learn about the rich history of the park and witness events from the past. For a bird's-eye view of the county, climb to the top of Bowman's Hill Tower, located on the grounds of the park. The tower provides visitors with breathtaking views across 14 miles of pristine countryside.
• Spend an afternoon biking along the Delaware Canal Towpath for an afternoon of scenic views and family fun. Stop along the way to enjoy a picnic in the park while taking in the picture-perfect sights.


text:
Submit News
Intel's Cuts Median Q3 Earnings Outlook by $1.1B USD
Jason Mick
September 7, 2012 12:53 PM
Recipient E-mail
Sender E-mail
Ultrabooks may not be selling as well as expected; 7.7 percent drop in outlook warns of trouble ahead
Intel Corp. (
) on Friday announced a trimming back its Q3 2012 earnings predicition from
an already gloomy
$14.3B +/- 0.5B USD to $13.2B +/- 0.3B USD. The 7.7 percent dip was blamed on a variety of factors.
Specifically, Intel
[Intel] is seeing customers reducing inventory in the supply chain versus the normal growth in third-quarter inventory; softness in the enterprise PC market segment; and slowing emerging market demand. The data center business is meeting expectations.
So what does that mean?
The inventory reductions could be attributable to several factors. First, Windows 8's
touch-screen mandate
for laptops may be leading to supply chain frustrations due to tight supply for the fast-growing display technology. Second, some OEMs have
expressed concerns
regarding the risk that Microsoft Corp.'s (
Windows 8
could be poorly received by customers. Changes like the
unwrapping of the Start Menu
into the new "
Windows 8 Theme
" side screen have
outraged some Windows traditionalists
Third, OEMs are moving towards the competition -- ARM Holdings, Plc.'s (
titular architecture. OEMs appear to be responding to ARM's conquest of the tablet and smartphone space by
racing their Windows RT
(ARM Windows 8)
products to market
. Lastly, OEMs may be reacting to weaker than expected Ultrabook demand, slowing purchase orders.
David Schmook, head of North American operations at Lenovo, said in
a previous interview
, "[Intel meeting its 2012 ultrabook targets is] going to require a very strong first couple of weeks of launch of Win 8. They'll be a lot bigger than they are now. I don't know if it will get all the way up to 40 percent."
The mobile sector's biggest winner, ARM is now looking to horn in to Intel's PC hegemony via its power-efficient system-on-a-chips. [Image Source: Digital Trends]
The good news for Intel is that ARM chipmakers who rely on third party fabs like Samsung Electronics Comp., Ltd. (
) and Taiwan Semiconductor Manufacturing Comp., Ltd. (
) (TSMC) have
barely squeaked onto the 28 nm node
. Meanwhile, Intel is already mass-producing at 22 nm and will move to
14 nm node in 2014
. Samsung has plans for 14 nm, but it appears Intel is at least a bit ahead at the moment.
Intel did offer another scrap of good news -- it thinks it can repurpose existing machinery/resources at its fabs for the 14 nm die shrink, which it says will allow it to cut capital spending from $12.9B USD to $12.1B USD. That should help it post a bit better net earnings numbers come Q3's official figures.
"I'd be pissed too, but you didn't have to go all Minority Report on his ass!" -- Jon Stewart on police raiding Gizmodo editor Jason Chen's home
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Prospect Education Center
645 North Prospect St.
Porterville, CA 93257
- Compare with other schools in Porterville
- Compare with nearby schools
- School Type: High School
- District: Porterville Unified
- Ranking compared to similar schools:
- Achieved API growth target: No
- Teachers with Full Credentials: 100%
- Teachers with Emergency Credentials: 0%
- School Schedule: Standard
- Grades: K-12
- K-3 Class Size: 1
- Grades 4-6 Class Size: 2
- Core Academic Courses: 8
Student Information:
- GATE students: 3%
- English learners: 14%
- Reclassified as English proficient: 7%
- Migrant education program participants: 6%
- Eligible for free/reduced price lunch: 48%
- Special education within past two years: 10%
Parent's Education:Overall Average Education4: 2.34
(based on the 96% who responded)
|Graduate School
|College Graduate
|Some College
|High School
|Not a High School
Student Ethnicity:
|American Indian
|Two or More
Median Home Price (Zindex) for zip code 93257:
Related Schools:
Bartlett Middle rank: 3 in Porterville
Belleview Elementary rank: 3 in Porterville
Butterfield Charter High rank: 1 in Porterville
Citrus High rank: A in Porterville
Granite Hills High rank: 4 in Porterville
Harmony Magnet Academy rank: 10 in Strathmore
John J. Doyle Elementary rank: 2 in Porterville
Los Robles Elementary rank: 3 in Porterville
Monache High rank: 6 in Porterville
Monte Vista Elementary rank: 3 in Porterville
Olive Street Elementary rank: 3 in Porterville
Pioneer Middle rank: 3 in Porterville
Porterville High rank: 4 in Porterville
Prospect Education Center rank: 1 in Porterville
Roche Elementary rank: 2 in Porterville
Santa Fe Elementary rank: 6 in Porterville
Sequoia Middle rank: 4 in Porterville
Strathmore High rank: 1 in Strathmore
Vandalia Elementary rank: 2 in Porterville
Vine Street Community Day rank: in Porterville
West Putnam Elementary rank: 3 in Porterville
Westfield Elementary rank: 5 in Porterville
- The State Rank is determined by a school's API Score in comparison to all other schools in California. (1 is the worst, 10 is the best). An equal number of schools occupy each rank. * This rank comes from the 2013 California Academic Performance Index (API) Growth report.
- The API Score is a number between 200 and 1000 that reflects a school's performance on statewide student assessments administered in 2013.
- Alternative Schools receive APIs but do not receive ranks
- Parent Education is the average of all responses where "1" represents "Not a high school graduate" and "5" represents "Graduate school."
- More information: 2012-13 Academic Performance Index Reports Information Guide (PDF; 629KB; 65pp.)
- "Conditional admission" is admission based upon either documentation of having received some but not all required immunizations and of not being due for any vaccine dose at the time of entry or upon documentation of a temporary medical exemption to immunization in accordance with Section 6050. Continued attendance after conditional admission is contingent upon receipt of the remaining required immunizations in accordance with Sections 6020 and 6035.
©2014 California School Ratings - Ratings on 9823 California Schools terms of use Feedback:


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To help you deploy commercial private and public clouds based on Windows Server 2008 R2 Hyper-V, System Center, and related products, Microsoft offers a set of programs and initiatives called Hyper-V Cloud. These programs can help you:
Build your own private cloud with help from the Hyper-V Cloud Deployment Guides and Hyper-V Cloud partners.
Get a pre-validated private cloud configuration from Hyper-V Cloud Fast Track OEM partners. Hyper-V Cloud Fast Track partners have worked with Microsoft to combine hardware and software offerings based on a reference architecture for building private clouds.
Find a service provider in the Hyper-V Cloud Service Provider Program who can host a dedicated private cloud for you.
Microsoft is also investing in a set of engagements to help customers with IaaS assessments, proofs-of-concept, and deployments with help from our partners or Microsoft Services. The investments are designed to help reduce the risk, cost, and time associated with testing and deploying a cloud environment.
Deploying Microsoft's private cloud infrastructure also positions you to take advantage of the Windows Azure public cloud platform through powerful identity, development, and management tools. These tools span across private and public cloud environments so that you can more easily build, migrate, or extend out to the public cloud and benefit from virtually unlimited scale and even greater efficiencies whenever you need it.


text:
When it comes to interior design, the team at Giannone Petricone Associates is best known for its restaurants. It seems fitting, then, that the model vignette they designed at Fabrik Condos — where they're also the architects — was a kitchen. "There's this gentle balance of slick, and rough and ready," Ralph Giannone, architect and principal, says of the space. He combined colour with texture while staying representative of the people he sees at the Richmond and Spadina location. "It's a very creative work/live area, and there's a young spirit to it — a young provocative culture to that neighbourhood." Suites at Fabrik, by Menkes Developments, range from 424 to 1,388 square feet and from the mid $200,000s to $495,990. The sales office is located at 770 Bay St., Toronto and is open Monday to Thursday from noon to 6 p.m. and weekends and holidays from noon to 5 p.m. For more information, call 416-591-7700 or visit menkes.com.
1. Chosen to elicit a response, the burgundy colour of the upper cabinets "has incredible vibrancy," Mr. Giannone says. The high-gloss lacquer cabinetry adds pop and pizzazz to the kitchen. "A bit of colour in your life is not a bad thing," the designer adds.
2. A growing trend among Mr. Giannone's residential clients, open shelving goes a long way to creating a casual kitchen. Not to mention, it's perfect for showcasing favourite cookbooks and accessories. "The kitchen is not strictly functional anymore," he explains.
3. "It's not smooth, it's not slick, it's actually got a tactile quality to it," the designer says of the wood veneer lower cabinets, which feature a deep grain texture. His goal? To offer a more "natural connection to the wood" — one that feels "authentic" to the touch.
4. The design concept behind the kitchen? Three Ls. There's the L shape created by the wood cabinetry, the L of the red cabinets and a third L in the shape of this white back-painted glass backsplash. "It's this wonderful balanced composition that we liked," Mr. Giannone says.
5. Scaled-down appliances complete the space. The most controversial among them? The microwave. "Typically we see a lot of those vent microwave units that sit above the range," the designer says. "We put it under the counter, clearing up the top to be as clean as possible."
6. This cast glass ball pendant light fixture adds sparkle. "It was important for us to create that niche to add a bit of design flourish," the designer says. A different light fixture with different personality would transform the space completely, he adds.


text:
Fun spaces with light and color
Inspire your child's creativity with this playful light by Philips. Timeless, cheery, and fun, it is a perfect addition to your child's bedroom. See all benefits
This Philips light is delivered with long cables to offer you a maximum flexibility during installation. Choose the perfect height matching your needs.


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Grandi announces second retirement
Thomas Grandi has retired again, and this time he means it.
Thomas Grandi has retired again, and this time he means it.
After 15 season on and one off, Grandi, one of the most successful male Canadian team skiers ever, has elected to forego another shot at the Olympics and re-retired. He had taken 2008 off, but returned hoping to answer some lingering questions. He made it into the points twice this season finishing 17th in slalom at Wengen and 25th in slalom at Alta Badia. He had hoped for better.
"I came back because I felt the pull of the Olympics and to attempt some things I wasn't able to on the first go around, a slalom win and an Olympic medal."
In his career, starting on the World Cup at Oppdal March 23, 1993, Grandi collected two GS wins (the only Canadian male to win a Cup GS) tallied five slalom and four GS podiums and 36 top ten scores between the two disciplines.
He was in seven World Championships topping out with a fifth in GS (top placing for a Canadian male) and sixth in slalom (3rd best placing by a Canadian male). Both his top placings came in 2005.
He made the Canadian Olympic teams of '94, '02 and '06 finishing with a nine in slalom (a bestfor Canadian males) and an 10th in GS (2nd best among Canadian males) with both tallies coming in 2006.
He also won 11 Canadian National titles and three U.S. titles.
He is married to Canadian cross country skier Sara Renner and they have a daughter, Aria.
"I now have a greater purpose and that is to be a father and a husband. My wife will continue her journey to Vancouver 2010 and I will be there to support her and take care of our daughter," Grandi said.
"I want to thank the people that cheered and supported me. I will miss you and I will miss crossing the finish and seeing #1," Grandi said. "There are lots of things I will miss, ski racing is amazing. I gave it a great run and I have no regrets."


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If you thought, as we did, that with the last of the Bugatti Veyron 16.4 supercoupes having been commissioned, there wouldn't be much news from Bugatti until its next model is announced in a couple of years, you were wrong. Seems that Bugatti designers and marketing partners are having as much fun with the topless Grand Sport model as they had building special-edition coupes like the Veyron Fbg par Hermès. The most recent case in point: the stunning Bugatti L'Or Blanc (that's "white gold") for which Bugatti teamed up with German porcelain maker Königliche Porzellan-Manufaktur Berlin (KPM).
Yes, porcelain. While we wouldn't have put it past Bugatti to render a Grand Sport entirely in porcelain, we might not want to be the ones to see if it could hit 253 mph, as do other Veyrons and Grand Sports. Fortunately, the L'Or Blanc's gorgeous, elaborately hand-painted blue-and-white body will not break into a million shards if a wayward shopping cart taps a fender. But porcelain is used in seven locations on the L'Or Blanc, including the wheel centers, fuel and oil filler caps, and the large "EB" badge on the back. Five places inside the cabin are rendered in porcelain as well: the center-console surround (basically the piece that wraps the transmission tunnel); signed trim plates on each side of the center console; the removable, diamond-polished dish atop the center console (part of a matching picnic set!); and a relief between the seatbacks depicting an elephant standing on its hind legs.
According to Bugatti, that elephant—which recalls a sculpture by Ettore Bugatti's younger brother, Rembrandt, that was used as the original radiator mascot of the Bugatti Royale—was the inspiration for the partnership between Bugatti and KPM. Bugatti claims that it has wanted to use that symbol all along as it has built Veyrons and Grand Sports, and the KPM partnership presented the perfect opportunity. It is a partnership that Bugatti intends to continue, the company says, so expect to see more porcelain, and more elephants, on future Bugattis.
Should you decide that you want a new porcelain butter dish with a 250-plus-mph Bugatti wrapped around it, this one-of-a-kind Grand Sport is still available for purchase for a mere €1.65 million, or about $2.4 million.
[nggallery id=184]


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Are You a Caregiver?
Perhaps you are doing things for your parent or spouse that they used to do themselves – like regularly running errands? paying bills? picking up medications? driving them to the doctor? arranging home care? preparing their meals? helping them dress? If you're spending more and more of your time and your physical and emotional energy seeing to the well-being of an older person you care about, you're a caregiver.
If you have primary responsibility for your grandchild or another young relative and are dealing with everything from behavior issues to school, medical appointments and legal and financial issues, you're a caregiver.
You may not think of yourself as a caregiver because in your view you're not doing anything out of the ordinary – It's only natural for family members to take care of each other.
But caregiving can be very stressful. It can affect your quality of life and even your health. It's important to get the services and supports you need to help you cope.
Caregiver programs in every borough can assist you with:
These programs don't replace what you do. They help you be a better caregiver.
Find a Caregiver Program in your borough
NYC Caregiver
One of the best sources of information for caregivers in New York City is NYC Caregiver. NYC Caregiver offers a wealth of information, resources and links for caregivers and grandparent caregivers. Topics range from caring for yourself to dealing with legal and financial issues.
DFTA's Alzheimer's and Caregiver Resource Center provides free counseling and assistance to New Yorkers caring for persons with Alzheimer's and other forms of dementia.
DFTA's Grandparent Resource Center is a resource for grandparents or other elders raising younger relatives.
Net of Care is Beth Israel Hospital's source of information and resources for New York City caregivers.
Next Step in Care of the United Hospital Fund offers easy-to-read guides to working with health care providers.
Willing Hearts Helpful Hands of the Parker Jewish Institute offers free respite to family caregivers in Queens and Western Nassau Counties. Trained volunteers help ease the caregiving burden.
Caregivers Connections provides weekly support groups, workshops and health-related classes over the phone for caregivers through conference call technology. Anyone living in the five boroughs can participate in this DOROT program.
The Eldercare Locator is a nationwide directory assistance service for caregivers. If you're worried about older relatives living in another city or state, the Locator will provide you with names and phone numbers of local organizations that offer the services they need. Call Eldercare Locator at toll-free 1-800-677-1116.
The National Family Caregiver Alliance offers information, advice, fact sheets and publications. A Family Care Navigator locates services anywhere in the United States.
The National Alliance for Caregiving supports caregivers with booklets, tip sheets, webcasts and other materials.


text:
I have been loving all of the dipped color trend.
Like dipped curtains…
Or dipped baskets,
and furniture!
So why not take that same idea and use it to dress up an ornament. You might remember last years Time Capsule Ornaments. I asked the kids a series of questions. Fun things that years from now we will enjoy reading! I loved it so much I wanted to come up with another idea to capture their innocence. Because we all know they grow up too fast!
I always try to encourage love and friendship between siblings. So with this years ornament I asked each of the kids to tell me what they loved about their brother or sister!
So cute to see what they wrote about each other!
The challenge always becomes how to know whose ornament is whose. That is where the color dipping came in. Pink for Blair, turquoise for Jude and robin's egg blue for Rhett!
I started with a clear plastic ball.
Rolled each note and tied it with ribbon.
Tucked it inside each ball.
Taped off the ball.
Then I painted each one.
I let them dry and put a total of two coats of paint on them. Then put a clear glossy coat so the paint wouldn't scratch off. Plus, you know I like a little sparkle! =)
I was absolutely tickled to death with how these turned out!! Maybe my favorite decoration yet! As an added treat Josh and I each wrote notes to the kids telling them what we loved about them!
P.S. Over at The Hollie Rogue, I am offering a free print from my shop!! Check it out!


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Four Star recruit Chris Little has a plan in mind. The 6-5, 342-pound offensive lineman knows how he's going to go about his commitment process and when he hopes his final decision will occur.
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I'm trying to come from ModX over to SilverStipe, thinking there is more flexibility. There seems to be some limitations that are quite frustrating to me.
I understand the concept of MVC, so please don't post back saying this shouldn't be allowed.
From within the admin...let's say I am editing the Home page's content. How could I include another page directly from here. I know I can do it from within the templates, but I build pages for clients, and a large majority of clients don't need to know HTML if they are using a CMS.
Secondly, is it possible to call something like :<% control MyLinkedImage %>$Image<% end_control %> from the content section of the HomePage? Again using the CMS?
I'm basically trying to find an easy way that my clients could include something or use controls that I've made for them without having to open a php or ss file.


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You can read about the announcement here. It's good to see the Eclipse Foundation, Zend Technologies, and IBM coming together on this and it will be interesting to see the reaction from the PHP community.
I would probably have a lot of use for such an IDE. How about you? Post your opinions in the comments.
Jim Hsu
PHP IDE approved by Eclipse Foundation
JohnFeller 110000RUW6 Tags:  eclipse php 3,446 Views


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Can anyone recommend a specialist in pigmentation anywhere in the US that may be able to help resolve my PIH ( post-inflammatory hyperpigmentation) post Fraxel repair. I am 10 months post laser and hyroquinone is not working. I have been using it for over six months.
Hyperpigmentation Treatment Specialist Recommendation?
Doctor Answers 1
Post laser hyperpigmentation is difficult to treat
Post Fraxel Repair hyperpigmentation is not that common if appropiate consultation is done prior to the treatment as to avoid sun exposure, and use of bleaching creams
Having said that I have seen a number of patients who have hyperpigmented after Fraxel Repair laser.
These were generally Fitzpatrick type 3 or 4 skin who agree that they did not stay out of sunexposure.
Treatments wise we have been able to help using Hydroquinone and none Hydroquinone based bleaching creams in combination with Retinoic acids as well as light chemical peels.
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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In the rapid-paced smartphone space platform updates are a big selling point for phones and a concern for existing phone customers. Platforms need updates to add features and squash bugs and customers are often watching and waiting for the next version to get released. Palm Pre and Pixi owners may be wondering about future updates to the webOS platform, given the looming takeover of Palm (s palm) by HP (s hpq). The "merger" won't take place for a few months but it's reasonable to think the webOS development effort at Palm is in a wait and see mode. HP is going to control things soon, and that's not a good climate for near-term advancement of the webOS platform.
HP didn't allay any concerns current Palm customers have with the initial statement by CEO Mark Hurd that HP "didn't buy Palm to be in the smartphone business." Smartphones like the Pre and Pixi were not even mentioned by HP about the forward plans for the webOS platform. HP quickly back-pedaled and cleared up the confusion by the statement, and stated that smartphones did play a future role in HP's webOS effort.
It is a legitimate question given lack of solid information about HP's plans for the platform, and Palm's current flux waiting for the takeover to happen– will there be any future updates for the Palm Pre and Pixi? No one involved wants to go on record to address this, but all parties involved make it clear that it is "business as usual", implying that future versions of webOS will appear for existing customers at some point. That's not the same as it actually happening, though.
Palm hasn't set the smartphone world on fire with massive sales of its handsets, but there are thousands of webOS phone owners affected by the merger. It doesn't help matters that Palm has already seen some key webOS developers leave the company prior to the HP merger being finalized. There are also some major telcos with a stake in this situation.
Related research on GigaOM Pro (sub. req'd): To Win In the Mobile Market, Focus On Consumers


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Can IPL Make Stretch Marks Worse?
Doctor Answers 10
IPL not much help for stretch marks
Striae or stretch marks are due to relatively rapid expansion of skin and/or significant loss of collagen due to corticosteroid. Fresh stretch marks may be red (or vascular) and IPL may be mildly helpful in getting them to become more blanched and white. That is pretty much it. I would start with prescription strength topical retinoid which can help to stimulate collagen and subtly improve texture of stretch marks. Ongoing studies are underway to confirm few anectodal reports of successful treatment of stretch marks with Fractional CO2 laser resurfacing.
Learn more: http://www.drwilliamting.com/What_s_New.html
No, you may even get some tightening with IPL treatment of stretch marks.
IPL will not make your stretch marks worse. You may even get a little bit of tightening. The heat produced by IPL is not enough to do much at all for stretch marks, but it certainly won't make them worse.
IPL and Stretch Marks
I haven't seen IPLs make stretch marks worse, not to discount your experience. Initially they may appear more red and perhaps swollen such that the stretch marks will appear worse but over time, it should improve-by how much? that's hard to say. I prefer to use a fractionated laser such as Fraxel or Profractional to improve stretch marks. It does a decent job on them depending on the severity. VBeam also does a good job on new onset stretch marks. Good luck to you, hope this information helps!
You might also like...
Stretch mark treatment
IPL should not make stretch marks worse. However, there are few treatments that will make these straie better. IPL and laser therapy can reduce redness or pigmentation of stretch marks, but will not entirely alleviate them. These are challenging problems. A conservative treatment regimen includes topical retinoids.
IPL for stretch marks
Improving stretch marks is difficult. Using a light based treatment to achieve this can be difficult. The idea is that the energy from the IPL will turn on some amount of collagen growth and treat any redness from visible vessels in the area. Realistic expectations are the key when trying to treat stretch marks and some other devices may be more helpful. As far as making you worse , That would be unusual and unexpected.
IPL treatment for stretch marks
IPL treatment might improve the appearance of your stretch marks slightly if your stretch marks are still red. It is highly unlikely that it would make the appearance of your stretch marks worse. There are some other modalities that might help your stretch marks, such as retinoid creams and some lasers. Unfortunately at this time we do not have a way to markedly improve the appearance of stretch marks, although many patients are happy with moderate improvement.
IPL and Stretch Marks
Stretch marks are NOT marks, they represent permanent CRACKS through the skin. These appear after rapid skin expansion (pregnancy, obesity, certain disorders such as Cushing's etc). As such, they cannot be erased by ANY modality (lasers, IPL,creams, lotions, rollers, pills, yoga etc, etc)
The ONLY thing we can do for them with IPL or lasers is to reduce the amount of blood vessels that run through these cracks and thereby render them white/silver earlier. Period. Attempts to shrink them are on-going but in my opinion have been much MORE predictably successful at shrinking the size of YOUR purse.
Intense Photo Light will not hurt the stretch marks but is just another way to separate you from your hard earned money, in my opinion.
IPL for Stretch Marks
We have been treating Stretch marks with lasers for the past 5 years and we have never seen any that have gotten worse because of Laser treatments. Many have not responded well, but we do not know any reason why they would get worse.
Stretch marks are extremely difficult to treat, especially if you have the thin, white or silvery type. We have treated many different stretch marks successfully and a good many without any appreciable results as well. The easiest type of marks to revise are new stretch marks that are pink (Caucasians) or brown (Hispanics, Asians and African Americans).
We have also had pretty good results revising the texture of marks - making them less rough and deep. But, thin white stretch marks with less color than the surrounding tissue are extremely difficult to treat and we do not have a good solution for them currently.
We do not use IPL to treat stretch marks. We use the following:
- Pulsed dye lasers (red/textured stretch marks)
- Q-switched lasers (brown/textured stretch marks)
- Aramis laser(textured stretch marks)
Strongly Doubt It
IPL treatment for stretch marks is an acceptable, though often fruitless, treatment for stretch marks.
It would seem on the surface of things that IPL treatments should be excellent for stretch marks. After all, they are supposed to disrupt collagen which signals the fibroblasts to pump out more collagen and elastin. An early study, published in Dermatologic Surgery 2002 Dec: 28 (12) indeed concluded that IPL was a safe and effective modality for treating stretch marks. However, a more recent study published in Aesthetic Plastic Surgery 2008 May; 32 (3) contradicted this finding. These investigators, although admitting there was histologic change,( improvements under the microscope, )did not feel that the clnical gains were minimal.
I can find nothing in the literature that would indicate that IPL WORSENS stretch marks. Further, it does not make sense to me biologically that it would.
You might try another form of treatment such as Fraxel. There is much more in the literature showing this to be a helpful in the fight against stretch marks. However, even Fraxel has its limitations so I would hate to see you disappointed a second time.
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


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Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data from RNAi therapeutic programs toward genetically validated targets in cardiovascular metabolic diseases, including ALN-PCSsc targeting PCSK9 for the treatment of hypercholesterolemia, and a newly named program, ALN-AC3, targeting apolipoprotein C-III (apoCIII) for the treatment of hypertriglyceridemia. These data are being presented at the Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) 2014 Scientific Sessions being held May 1-3 in Toronto, Ontario. In an oral presentation titled " A Subcutaneous, Potent and Durable RNAi Platform Targeting Metabolic Diseases, Genes PCSK9, ApoCIII and ANGPLT3" new pre-clinical data utilizing the company's GalNAc-siRNA conjugate platform demonstrated robust and durable knockdown of these key cardiovascular metabolic disease targets. Amongst other data, Alnylam presented new single-dose durability data for ALN-PCSsc showing robust knockdown of PCSK9 and reductions in LDL-C that support once-monthly and possibly once-quarterly subcutaneous dosing regimens. Specifically, a single dose of ALN-PCSsc maintained greater than 50% LDL-C reductions for over three months in the absence of statin co-administration. The company plans to file an investigational new drug (IND) application, or IND equivalent, for ALN-PCSsc by late 2014 or early 2015. "As evidenced by these data presented at ATVB, we are building the beginnings of a promising pipeline of RNAi therapeutics toward genetically validated disease targets in the cardio-metabolic space. We see this as an attractive area for continued investment for Alnylam given the large number of liver-expressed disease-causing genes and the emerging profile of our GalNAc-conjugate platform enabling subcutaneous delivery with potent disease gene knockdown, a wide therapeutic index, and highly durable effects. These features are exemplified with ALN-PCSsc, where new non-human primate pre-clinical results demonstrate significant knockdown of PCSK9 and reductions in LDL-C with very durable effects, lasting over three months. We believe that this level of durability should readily support a once-monthly and possibly a once-quarterly subcutaneous dosing regimen, and thus represents what should be a highly competitive profile with anti-PCSK9 monoclonal antibodies. We look forward to advancing ALN-PCSsc toward clinical trials by the end of this year or early next," said Kevin Fitzgerald, Ph.D., Senior Director, Research at Alnylam. "In addition, new rodent data with ALN-AC3, our GalNAc-siRNA conjugate targeting apoCIII, showed up to 95% knockdown of ApoCIII and up to 68% reduction in triglycerides. These pre-clinical results warrant further efforts to advance this new RNAi therapeutic program into later stages of development."
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Jason McKenzie Web Services
JMWS is a web design, SEO, web marketing and e-commerce company located in Boise, Idaho. While we are located in Boise Idaho, we have clients all over the United States. For custom quality webdesign at a price you can afford please contact us. The consultation is free and if we can't offer you the solution that will best fit your needs, we will send you where you can.
Location Information
Boise, ID 83713
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Phone: (208) 340-6842
Services Offered by Jason McKenzie Web Services
Jason McKenzie Web Services Portfolio
Clean Clear Cut Magento eCommerce Stores
Look what we did for CeeDubs.com. They love it!! We also incorporated their blog.
Small Business Custom Sites
Fun, quick, and easy. Have a new custom site at a price you can afford. Contact us for a free no obligation quote. We are located in Boise, Idaho and work with clients across the U.S.
Services Used: CSS + Google Apps + HTML + PHP + SEO + Web Design
Word Press Sites
Custom Word Press Web site integrated with Pay Pal. Easy to navigate, user friendly.
Services Used: WordPress


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Cannot get script to open Excel file
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Joined: 17 Aug 2009
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Posted: 17 Aug 2009 at 5:52pm
I need to do a SaveAs on an attachment with Excel so it is in the newest version of Excel. Here is my script:
Sub Main()
' commands start here
WScript.Sleep 10000
strFile = "c:\reports\wrongformat\content_wrong.xls"
Set objExcel = CreateObject("Excel.Application")
strFile1 = "c:\reports\content.xls"
objExcel.Workbooks.Open strFile
Set objSheet = objExcel.ActiveWorkbook.Worksheets(1)
objExcel.Application.DisplayAlerts = False
objExcel.ActiveWorkbook.SaveAs strFile1, -4143
End Sub
If I run the script manually, it works perfectly. If Email2DB runs the script, it gives this error:
Script error: (&H800a03ec) Microsoft Office Excel cannot access the file 'c:\reports\wrongformat\content_wrong.xls'. There are several possible reasons:
• The file name or path does not exist.
• The file is being used by another program.
• The workbook you are trying to save has the same name as a currently open workbook. Line 11
As you can see, I am working with local directories only, no network locations. I opened the permissions wide up for Everyone. I can't figure out why the script won't work when Email2DB runs it.
Edited by Typoman - 17 Aug 2009 at 6:58pm
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The problem here is that the Microsoft Office Scripts can not be called or created via a Service, this is what Email2DB runs as.
When running through the script editor you are running as your user, this is why it goes through fine.
When Email2DB processes an email it is as a service and as such the script cannot be executed and you are presented with the Script Error.
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It's a slow summer and I thought this Twitter exchange was a little funny:
POB: havent slept in 33 hrs....
Sonny: don't nobody care
POB: y u steady hatin?
Sonny: lol, you know you my boy
POB: ya aight
Printable View
" don't nobody cares" haha
I wonder why POB can't sleep?! being nervous about being unemployed soon would make anyone sleepless I suppose.
I feel old when I read stuff like that. I only understood half of it.
Far more interesting than what I seen up on the HoopsHype.com Twitter feed:
Donyell Marshall: On way to hospital to get these cyst taken out my arm and back.
Read more: http://hoopshype.com/twitter.html#ixzz0nCBZZEA0


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Editor's Note: TheStreet ratings do not represent the views of TheStreet's staff or its contributors. Ratings are established by computer based on metrics for performance (which includes growth, stock performance, efficiency and valuation) and risk (volatility and solvency). Companies with poor cash flow or high debt levels tend to earn lower ratings in our model All three major indices are trading up today with the Dow Jones Industrial Average ( ^DJI) trading up 47 points (0.3%) at 15,382 as of Tuesday, May 21, 2013, 12:50 PM ET. The NYSE advances/declines ratio sits at 1,570 issues advancing vs. 1,367 declining with 136 unchanged. The Financial Services industry currently is unchanged today versus the S&P 500, which is up 0.2%. A company within the industry that increased today was T. Rowe Price Group ( TROW), up 0.82. TheStreet Ratings group would like to highlight 5 stocks pushing the industry higher today: 5. Discover Financial Services ( DFS) is one of the companies pushing the Financial Services industry higher today. As of noon trading, Discover Financial Services is up $0.84 (1.75) to $49.04 on average volume Thus far, 2.4 million shares of Discover Financial Services exchanged hands as compared to its average daily volume of 4.9 million shares. The stock has ranged in price between $48.33-$49.23 after having opened the day at $48.36 as compared to the previous trading day's close of $48.19. Discover Financial Services, a bank holding company, provides direct banking and payment services in the United States. It operates in two segments, Direct Banking and Payment Services. Discover Financial Services has a market cap of $23.4 billion and is part of the financial sector. The company has a P/E ratio of 10.7, below the S&P 500 P/E ratio of 17.7. Shares are up 25.0% year to date as of the close of trading on Monday. Currently there are 14 analysts that rate Discover Financial Services a buy, no analysts rate it a sell, and 4 rate it a hold. TheStreet Ratings rates Discover Financial Services as a buy. The company's strengths can be seen in multiple areas, such as its revenue growth, solid stock price performance, growth in earnings per share, increase in net income and expanding profit margins. Although no company is perfect, currently we do not see any significant weaknesses which are likely to detract from the generally positive outlook. Get the full Discover Financial Services Ratings Report now. Exclusive Offer: Jim Cramer's 'go-to' small/mid-cap guru Bryan Ashenberg only buys stocks he thinks could return 50-100%. See his top picks for 14-days FREE.
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text:
Iqua first hit the scene with its Iqua 603 SUN, a hands-free Bluetooth headset that maintains a full charge almost indefinitely due to its built-in, tiny solar panel. This week, the company announced that the Iqua Vizor SUN, a solar-powered Bluetooth device designed for use in the car and first announced in September, is in stock for $119.95 in the Apple Store.
The Vizor SUN is a hands-free speakerphone that the company claims will provide hours of talk time, and can also recharge itself using the sun's natural energy, without having to connect a wire to your car's DC power socket or cigarette lighter. In addition, the Vizor SUN offers the usual array of controls, including answer call, reject call, end call, redial the last number used, and volume adjust.


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TEMPE, Ariz. - As Josh Hamilton hammed it up with a series of good-natured wisecracks, a serious Albert Pujols sat in silence two seats away, arms crossed.
Mike Trout was in the middle, grinning.
"Hello guy in the booth, what's your name?" Hamilton asked.
"Happy Valentine's Day."
"Do I have time to go to the bathroom?"
The Los Angeles Angels' new slugger might have the biggest personality of this talented trio. Biggest swing? To be determined, though Pujols and Trout aren't about to pick against Hamilton in a home run contest.
Hamilton led an entertaining back-and-forth for 30 minutes Thursday at a cactus-lined hotel perched above the team's spring training site in the Arizona desert.
No joint nickname for these power hitters. Not yet, anyway.
The Angels will hold their first full-squad workout today at Tempe Diablo Stadium with the three stars together at last. Hamilton, the 2010 AL MVP, received a $125 million, five-year contract in mid-December, a year after Pujols' $240 million, 10-year deal.
Manager Mike Scioscia insists he's not getting too excited until everybody is healthy and in the lineup come opening day, which still feels way off.
Scioscia realizes with his roster, there's no avoiding the constant attention that will be on his club in Orange County considering the high-profile moves and a lineup of stars.
"It's going to be good to get them in the clubhouse," the skipper said before the pitchers and catchers worked out Thursday. "I think we're excited about getting that whole group in here tomorrow and getting started. We know what we need to accomplish in the spring and we're going to focus on that, and from there we're going to look toward opening day once we get through spring. Hopefully, you get through spring in one piece and get guys where they need to be and you can watch that lineup play that day and hopefully for a long time from there."
Hamilton and Pujols have more than one thing in common. They both have a strong faith, and have even traded Bible verses at first base.
"He's a great guy. Every time he goes to first base, it seems like he always has a verse for me, 'What you got for me?'" Hamilton said.
This spring, Pujols is easing back from arthroscopic right knee surgery in October, but plans to be full strength by opening day.
Hamilton has maintained his weight at 225 pounds, where he ended last season. He cut out bread and gluten, then added juice drinks.
"Don't use a headline 'Hamilton juicing,'" he quipped. "I already feel better. My joints feel better, energy level's up, caffeine's down. I didn't lose any weight, I just didn't gain any."
Scioscia has thought about lineups with Hamilton batting second but plans to go with Pujols in the No. 3 slot and Hamilton cleanup to best take advantage of Pujols' on-base percentage.
"Right now to try and lengthen our lineup out to where we want to be, it makes more sense to have him in the cleanup spot and we'll adjust as our offense evolves, if we have to," Scioscia said.
The Angles are in a must-win now mode after an 89-73 season in 2012 for a third-place finish in the AL West and a third straight year out of the playoffs.
The Angels are counting on the addition of Hamilton to get them off to a fast start after beginning 6-14 last spring and then enduring a 5-13 funk in the first 19 days of August.
"We can't have that one little hiccup at the beginning of the year and find ourselves scoreboard watching," Trout said.
Hamilton fills a void in center field left by the departure of clubhouse leader Torii Hunter. Trout will shift to left, and said that's fine with him if it helps the Angels become a contender again.
The 31-year-old Hamilton hit a career-high 43 home runs last season and batted .285 with 128 RBIs in 148 games.
"Josh was a little streaky last year, but still the numbers are there and that threat's there and that production is there," Scioscia said.
"And that's going to be huge for us."
Pujols certainly will be looking to boost his April numbers and be more consistent.
He batted .190 with no homers in April last year, then finished with a .285 average with 30 homers, 50 doubles and 105 RBIs. Trout, meanwhile, produced one of the most impressive rookie seasons ever. He led the AL in runs (129) and stolen bases (49), hit 30 homers with 83 RBIs and finished second in the batting race at .326 behind Triple Crown winner Miguel Cabrera.
"Last year was last year. Let's talk about 2013," Pujols said. "I'm one of those guys I don't like to look for excuses. Sometimes you try to press, that's human nature. If you don't do that, you aren't human."
If all goes as Scioscia envisions it, Pujols and Hamilton will provide the kind of middle-of-the-order punch the Tigers have in Cabrera and Prince Fielder.
"We hope, much along the lines of what you saw with Prince Fielder and Miguel Cabrera, those two guys in the middle of the order fed off each other and really formed an incredible middle of the lineup," Scioscia said. "And I think we have the potential to do that with Josh and Albert. I do think those guys are going to get comfortable, feed off each other and be productive."
Their bond might go deeper than just on the field, too.
Hamilton, who has acknowledged he will always be an addict, believes he has already begun to build a reliable support system like the one he had the past five years in Texas.
"Moving to a new city it's important to have someone hold you accountable," he said. "You find guys who you put in your circle."
On Thursday, Hamilton only had to look to his left and see Trout and Pujols. Clearly, two guys he can count on.
Pujols makes it clear the Angels won't get ahead of themselves at this early stage, even if the end goal is getting back to the playoffs.
"There's no guarantee to us," he said. "Let's concentrate on today."


text:
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text:
Results - October 2009
Computational Alanine Screen 1ILP CXCR1 project
Chemokines are small soluble chemotactic proteins that are recognized by chemokine receptors on immune cells and other cell types. They direct these cells to their site of action in inflammation or development.
Crystal structure of 1ILP
Due to their role in chronic inflammation, allergies, autoimmune diseases and cancer, chemokines have become a target in drug discovery. Starting from existing structural data (PDB: 1ILP) of a chemokine interleukin-8 CXCL8 bound to a N-terminal peptide of its corresponding receptor CXCR1. We used the all-atom free-energy PFF02 on POEM@HOME to calculate the interaction energy differences between the wild-type complex and all alanine-exchanged peptides to determine the interaction hot spots. These changes are rationalized by decomposing the interaction energy differences into ther most impotant physical contributions.
Structure of the Interleukin dimer bound to the 19 N-terminal amino acids of its cognate receptor CXCR1. The N-terminal methionine was exchanged for alanine.
The results of our analysis agree with available experimental functional assays, indicating that this approach is suitable for computational alanine screening and may help to identify competitive peptides as starting points for the development of inhibitors of protein-protein interactions for pharmaceutically relevant targets.
The following two graphs show the results for the docking simulations carried out on POEM@HOME.
Energy vs. RMSD plot of all relaxed conformations of 1ILP yields two candidate conformations with nearly identical energy. The chemokine is shown in blue, while the competing peptide conformations are shown in red and magenta.
Further relaxation of the lowest 60 conformations uniquely identified the native model to within 0.5 Angstroem. The chemokine is shown in blue, the native model in red and the docked model as spheres.
A link to this article is for example here. If you do not have access to this article, very often libraries provide access free-of-charge.