text:
Chromatography Research International
Volume 2011 (2011), Article ID 860168, 8 pages
LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avendia Ipiranga, 2752/402, 90610-000 Porto Alegre, RS, Brazil
Received 12 July 2010; Revised 3 December 2010; Accepted 14 December 2010
Academic Editor: Toyohide Takeuchi
Copyright © 2011 Magda T. Martins et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Liquid chromatography (LC) and ultraviolet spectrophotometric (UV) methods for lamotrigine (LTG) determination were validated. The LC separation was achieved on an ACE RP-18 as stationary phase and 0.3% triethylamine in water (v/v) pH 4.0 : methanol (62 : 38, v/v) as mobile phase. Detection was achieved with a photodiode array at 279 nm. The detection response for LTG was linear (). The specificity and stability were proved using stress conditions. The CV (%) values for intraday and interday precision were less than 2.0%. The method was accurate and robust. The -student test proved that the LC and UV methods are interchangeable.
1. Introduction
The development of new antiepileptic drugs for epilepsy over the last decade has been spurred by the fact that the available antiepileptic drugs did not provide optimal care for patients with epilepsy [1]. LTG is a new antiepileptic drug that is currently used as an add-on therapy or monotherapy in patients with partial and secondary generalized seizures [2]. Lamotrigine (Figure 1), 3,5-diamino-6-(2,3-dichorophenyl)-1,2,4-triazine, C9H7Cl2N5, mol. Wt. 256 g, is chemically unrelated with other antiepileptic drugs in current use, differing in structure and pharmacology. LTG has a broad spectrum in antiepileptic activity [3, 4]. The efficacy of seizures treatment depends on the drug quality, which requires suitable monitoring. The quality controls of the anticonvulsant drugs are fundamental for the well-being of patients and are imperative for the development of routine analytical methods that can reliably measure these. Assays reported in the literature for lamotrigine determination in biological fluids include high-performance liquid chromatography [4–17]. Emami and collaborators [18] described a method for lamotrigine tablets by high-performance liquid chromatography, using reversed phase and related substances which may coexist in solid pharmaceutical dosage forms. Youssef and Taha [19] described methods for lamotrigine determination in tablets using a liquid chromatography with reversed phase and colorimetric method at 529 nm. A literature review revealed that an official monograph of LTG in tablets does not present in any pharmacopoeia. Recently, a validated stability-indicating LC method for lamotrigine using acetonitrile and aqueous trifluoroacetic acid was published [20]. Meanwhile, the aim of the present study was to develop and validate rapid, simple, and selective liquid chromatography method for LTG quality control in tablets. Furthermore, stress testing of the drug was also conducted, as required by the International Conference on Harmonization [21] to support the suitability of the method, corroborating the main advantage of this process in addition to the economic advantages of routine tests against the proposed methods found in the literature. The development of stability-indicating analytical method provides information about possible degradation pathways and demonstrates the capability of the analytical method in distinguishing LTG in presence of degraded products. The ICH guidelines requires performing stress testing of the drug substance, which can help identify the likely degradation products and can be useful to establish degradation pathways [21]. Due to this, the present method was validated by specificity, in placebo samples and forced-degradation samples, linearity, accuracy, repeatability, intermediate precision, and robustness.
2. Experimental
2.1. Materials
Lamotrigine reference substance (assigned purity of 99.41%) was supported by Cristália Produtos Químicos Farmacêuticos LTDA (São Paulo, Brazil). The pharmaceutical dosage form (manufactured by Cristália Produtos Químicos Farmacêuticos LTDA, São Paulo, Brazil) as tablets for oral administration (claimed to contain 100 mg of lamotrigine per tablet, and the following inactive ingredients: mannitol, pregelatinized starch, dibasic calcium phosphate, corn starch, sodium starch glycolate, magnesium stearate, crystallized silicon dioxide, and tartrazine yellow colorant) was obtained commercially.
LC-grade methanol was purchased from Tedia (Fairfield, USA). Triethylamine and phosphoric acid were purchased from Merck (Darmstadt, Germany). Distilled water purified by a Millipore Milli-Q UF-Plus apparatus (Millipore) was used to prepare the mobile phase. The 0.01 M HCl solutions were prepared using Quimex (Merck, Brazil) concentrated hydrochloric acid and purified water.
2.2. Instrumentation and Chromatographic System
The assay was developed and validated using an Agilent liquid chromatograph (Santa Clara, CA, United States) equipped with a model LC-1200 series with G1311A Quaternary pump, ALS G1329A auto sampler, TCC G1316A thermostat column compartment, DAD G1315B photodiode array detector, SCL-10Avp system controller and ChemStation manager system software which was used to control the equipment and calculate data from the LC system. Chromatographic separation was achieved in an ACE RP-18 octadecyl silane column (150 mm × 4.6 mm i.d., particle size 5 μm) maintained at room temperature. The mobile phase was composed of triethylamine 0.3% in water (v/v) pH 4.00, adjusted with phosphoric acid 10% and methanol (62 : 38, v/v). The flow rate was 1.0 mLmin−1 with isocratic elution. The mobile phase was prepared daily, filtered through a 0.45 μm membrane filter (Millipore) and degassed by the chromatographic system prior to use. LTG was determined by UV photodiode array at 279 nm. The injection volume was 20 μL, and the time run was 10 minutes.
An UV-VIS recording spectrophotometer UV-160A (Shimadzu, Kyoto, Japan) at 267 nm, using 1.0 cm quartz cells and S M software was used for the development and validation of UV method.
The Digimed potentiometer, model DM-20 (São Paulo, Brazil), was used to determine the pH of solutions.
The ultrasonic bath UCS 5000 (Unique, São Paulo, Brazil) was used for solutions preparation.
2.3. Samples Preparation
2.3.1. Samples for LC Analysis
The LTG standard stock solutions were prepared by dissolving pure, accurately weighed compound in methanol, obtaining 500 μgmL−1. This solution was kept in an ultrasonic bath for 15 minutes. Appropriate dilution of this stock solution was prepared using mobile phase to obtain 40 μgmL−1, as the reference standard solution.
Twenty tablets were weighed, and the average weight was calculated. Tablets were crushed to a fine powder. An amount of the powdered tablets, equivalent to 25 mg of lamotrigine, was transferred to 50 mL volumetric flask with methanol. This flask was kept in an ultrasonic bath for 15 minutes and then shaken for 15 minutes by a mechanical shaker. The volume was completed with methanol and the solution reached 500 μgmL−1. The solution was filtered through a 0.45 μm membrane filter (Millipore), and an aliquot of the filtrate (4.0 mL) was diluted with the mobile phase in a 50 mL volumetric flask to 40 μgmL−1, as the working sample solution.
2.3.2. UV Method Samples
Lamotrigine reference standard was accurately weighed (10.0 mg) and dissolved with 10 mL of 0.01 M HCl in a 20 mL volumetric flask. It was kept in an ultrasonic bath for 15 minutes. The volume was completed with the same solvent (500 μgmL−1). An aliquot of 2.0 mL of this solution was diluted in a 50 mL volumetric flask, and the volume was completed with the same solvent (20 μgmL−1).
Twenty tablets were accurately weighed and finely powdered. An amount equivalent to 25 mg of lamotrigine was transferred to a 50 mL volumetric flask with 25 mL of 0.01 M HCl. This volumetric flask was kept in an ultrasonic bath for 15 minutes and shaken by a mechanical shaker for 15 minutes. The volume was completed with the same solvent (500 μgmL−1), and the solution was filtered. An aliquot of 2.0 mL of this solution was diluted in a 50 mL volumetric flask, and the volume was completed with 0.01 M HCl (20 μgmL−1).
2.4. Validation of LC Method
2.4.1. Specificity
At the first moment, the specificity was evaluated through the placebo sample solution. It was prepared in the same way of the sample solution in the presence of all inactive ingredients of the formulation but without lamotrigine. Forced degradation studies were performed in order to provide an indication of stability and method specificity [21–23]. The main focus has been generating representative degradation samples for developing stability-indicating analytical method. Stress testing should include the effect of temperature, oxidation, photostability, and susceptibility of the drug substance to hydrolysis across a wide pH range when in solution [22]. Samples submitted to forced degradation should be controlled to avoid the appearance of secondary degradation products. It is interesting to degrade around 5–15% [22, 23]. The stress conditions employed were UV C light, oxidant media, acid, base, temperature, acid associated with heat, and base associated with heat. Samples were analyzed against freshly prepared solutions. The solutions were analyzed through their chromatographic profiles and the peak purity tool was used. The placebo solutions were submitted to the same degradation conditions to verify any interference. All solutions were injected in triplicate.
2.4.2. Effect of UV Light
An amount of powder equivalent to 20 mg of lamotrigine from crashed tablets was transferred to a 20 mL volumetric flask with methanol (1 mgmL−1); the solution was submitted to an ultrasonic bath for 15 minutes. An aliquot of 1 mL from this solution was placed in a stopped-flow spectrophotometer 1 cm cell (Plastibrand) and wrapped with parafilm. The lamotrigine methanol solutions () were exposed for 24 h to UV chamber (100, 18, 17 cm) with mirrors and an UV fluorescent lamp, model 30 W Ecollume ZW emitting radiation at 254 nm. After the degradation treatment, the samples were diluted to 40 μgmL−1 with mobile phase. Samples submitted to identical conditions, but protected from light by aluminum foil, were used as control.
2.4.3. Effect of Alkaline Hydrolysis
In order to carry out the alkaline hydrolysis and acid hydrolysis, a stock solution of lamotrigine was prepared in methanol (2.0 mgmL−1). An aliquot of 5.0 mL was diluted in a 10 mL volumetric flasks with 1.0 M NaOH and 1.0 M HCl. The solutions were allowed to react for 2 h and 7 h at room temperature. After that, 2.0 mL of the solutions were transferred to a 50 mL volumetric flask, neutralized with 1.0 M HCl (alkaline solution) and 1.0 M NaOH (acid solution) and then diluted with mobile phase to 40 μgmL−1 (), filtered, and analyzed by LC method.
The effects of both parameters (hydrolysis and heat) were also evaluated, since no degradation peaks could be observed under acid or base conditions. 2.0 mL were kept from the acid and alkaline stock solutions and allowed to react for 2 h. The flasks containing the solutions were kept in a bath with controlled temperature (80°C) for 2 h. After that, the solutions were neutralized with 1.0 M NaOH (acid solution) and 1.0 M HCl (alkaline solution), diluted with mobile phase to 40 μgmL−1 (), filtered, and analyzed by LC method.
2.4.4. Effect of Oxidation
To promote the oxidation, a stock solution was prepared in methanol (2.0 mgmL−1). An aliquot of 5.0 mL was diluted in a 10 mL volumetric flask with 30% hydrogen peroxide solution and left to react for 6 h at room temperature. After that, the solution was diluted in mobile phase to 40 μgmL−1 (), filtered, and analyzed by LC method.
2.4.5. Effect of Heat
An amount of powder equivalent to a 50 mg of lamotrigine was transferred to a 50 mL volumetric flask with HCl 0.01 M. An aliquot of 1.0 mL from this stock solution was placed in a glass flask and kept in an oven for six days to study the effect of heat (60°C ± 1). After the specified time, this solution was diluted to 40 μgmL−1 with mobile phase.
2.5. Linearity and Limits of Detection (LOD) and Quantitation (LOQ)
The linearity of the method was tested on standard curves ranging from 10.0 to 80.0 μgmL−1. Appropriate amounts of lamotrigine stock solution (0.5 mgmL−1) were diluted with mobile phase and prepared in triplicate. The linearity was evaluated by linear regression analysis, which was calculated by the least-square regression analysis.
The LOD (detection limit) and LOQ (quantitation limit) were evaluated using a sequence of dilutions with known concentrations. The minimum concentration at which the lamotrigine can be detected (LOD) and quantified (LOQ) was established by the ChemStation software with the measure of S : N (signal : noise) in the HPLC equipment [24].
2.5.1. Precision
Precision of the method was determined by repeatability (intraday precision) and intermediate precision (interday precision), analyzing six lamotrigine sample solutions prepared at 40.0 μgmL−1 in triplicate in three different days [25, 26]. The results were expressed as coefficient of variation (CV%) of the measurements.
2.5.2. Accuracy
This parameter was determined by the recovery test, which consisted of adding known amounts of lamotrigine reference standard to the samples' solutions in the beginning of the process. This test was realized by assaying three different solutions, three replicates each, containing 10.0, 20.0, and 40.0 μgmL−1 of lamotrigine standard solution added to lamotrigine sample solution, corresponding to 25, 50, and 100% of the nominal analytical concentration of lamotrigine (40 μgmL−1).
2.5.3. Robustness
Robustness was evaluated by small changes made in the chromatographic conditions, such as pH values of aqueous phase, percentage of methanol in the mobile phase, and flow rate. For each experimental run, two injections were performed: lamotrigine sample and lamotrigine standard solution, both with the same concentration (40 μgmL−1).
2.5.4. System Suitability
System suitability tests are based on the concept that the equipment, electronics, analytical operations, and samples to be analyzed constitute an integral system that can be evaluated as such. This parameter ascertains the suitability and effectiveness of the operating system [26, 27]. The parameters available were theoretical plates, capacity factor, peak asymmetry, or tailing factor.
2.5.5. Solutions Stability
Lamotrigine stock standard solutions were prepared in methanol and 0.01 M HCl (500 μgmL−1), stored at 4°C, and analyzed in the period of a month by LC method to verify this stability in both solvents.
2.6. Validation of UV Method
2.6.1. Specificity
The method specificity evaluation was performed by preparing a placebo containing the same excipients of the commercial product.
2.6.2. Linearity
The linearity was analyzed through the standard curves ranging from 5.0 to 40.0 μgmL−1. A stock solution (500 μgmL−1) of lamotrigine was prepared, used for dilution and preparation of three calibration curves in the same day with the following concentrations (5.0, 10.0, 15.0, 20.0, 25.0, 30.0, and 40 μgml−1). The linearity was evaluated by linear regression analysis, which was calculated by the least square regression method.
2.6.3. Precision
The precision was determined in six replicates of lamotrigine samples (20.0 μgmL−1) by repeatability (intraday precision) and interday precision. The CV% was determined.
2.6.4. Accuracy
Accuracy was performed by recovery of known amounts of lamotrigine reference standard added to the samples in the beginning of the process. This test was realized by assaying three different solutions, three replicates each, containing 5.0, 10.0, and 20.0 μgmL−1, of lamotrigine standard solution added to lamotrigine sample solution, which corresponds to 25, 50, and 100% of the nominal analytical concentration of lamotrigine (20 μgmL−1).
2.6.5. Robustness
The robustness was evaluated making changes in the step of drug extraction, using ultrasonic bath for 15 minutes, mechanical shaker for 15 minutes, or both. Three replicates of each one were used. The methods were compared and analyzed by analysis of variance (ANOVA).
2.6.6. Sensitivity
The LOD and LOQ were mathematically determined using directly the calibration plot. It as calculated as 3.3 ρ/S and 10 ρ/S, respectively, where ρ is the standard deviation of intercept and S is the slope of the calibration plot [22].
3. Results and Discussion
3.1. LC Method
3.1.1. Selection of Chromatographic Conditions
The HPLC procedure was optimized to develop a method to determine lamotrigine when the drug was submitted to degradation conditions. The literature review revealed that, at this time, the HPLC has been considered as the technique of choice for the separation and determination of lamotrigine. The chromatographic conditions were chosen after words to test different mobile phases with different proportions of organic solvent. Methanol is commonly used as an organic solvent in HPLC, and reversed-phase chromatography was performed with various mixtures of methanol-water [23]. The pH value of aqueous phase was checked before mixing with methanol. The adjustment of solution to pH less than 4.5 results in lamotrigine predominantly as the ionized form () with λmax at about 270 nm. The acid value of pH is important to maintain the lamotrigine soluble in the mobile phase. Aqueous phases containing phosphate buffers were also described in the literature. Acceptable separations, with a retention time of 6.5 minutes for lamotrigine, were obtained using an Ace RP-18 octadecyl silane column (150 mm × 4.6 mm, particle size 5 μm) and the mobile phase composed of 0.3% triethylamine in water (v/v) pH 4.0 and methanol (62 : 38, v/v). A simple mobile phase without buffer addition is an advantage in routine analysis, since it requires short time in equipment and column cleaning. The basic additive triethylamine was important to improve peak shapes that could be observed in Figure 2. The retention time observed allows a fast determination of the drug, which is important for routine analysis.
3.1.2. Specificity
An essential requirement for the separation analysis is to verify the purity of the separated species and the conviction that nothing is interfering with the principal peak [24]. The LC chromatograms recorded for the mixture of the inactive ingredients revealed no peaks within retention time around 6.5 minutes, and the peak purity was 99.99% (Figure 3).
Lamotrigine solutions were submitted to forced degradation studies to induce the presence of degraded products. The guidelines explicitly require conduct of forced decomposition studies under a variation of conditions, like pH, light, oxidation, dry heat, and separation of drug from degradation products [24]. The assays with UV light are an integrate part of stress tests. In literature review, guanabenz, which is chemically similar to lamotrigine, is sensitive to acid, alkali and light stress conditions [24, 25]. When submitted to UV radiation for 24 h, the drug content exhibited a decrease (9%), but there were no degradation peaks detectable in the chromatogram. Under alkaline conditions, lamotrigine content had a decrease for 2 h (12,6%) and more extensively for 7 h (23,7%), but there were no detectable degradation peaks. The samples submitted to acid conditions showed a similar degradation profile to that done in alkaline settings but less was extensive (8,8%) for 2 h and (14,9%) for 7 h. When the exposition was an association of acid and heat or base and heat, the extent of degradation was higher and additional peaks emerged. The good resolution of lamotrigine peak and the other ones in both situations could be observed (Figure 4). Lamotrigine peak purity was 99.99% for acid and alkaline conditions associated with heat. We could observe two degradation products more hydrophobic than lamotrigine that elutes with a longer retention time on a reversed-phase column. They appeared in 8 minutes (D8) and 10 minutes (D10). These degradation products are formed by promoting of heat being more extensively in alkaline conditions. The peak purity of D8 was 99.97% and for D10 it was 99.99%, suggesting interesting products to be isolated and studied. This method could separate these degradation products, becoming a stability-indicating method.
When the oxidation with H2O2 30% was promoted, it did not show any emerged peaks in the chromatogram and the lamotrigine content had a little decrease (5, 3%). The same situation occurred with the temperature (60°C) for 6 days that did not promote lamotrigine degradation (2, 3%), demonstrating that temperature is not a preponderant factor in lamotrigine degradation.
The chromatographic peak purity tool, applied for lamotrigine peak in the chromatogram, demonstrated that it was pure in all cases, confirming the absence of other substance in the same retention time. Since the main peak of lamotrigine was not found attributable to any other peak, the method proves to be suitable to analyze this drug. When the area decreased and degradation peaks were not observed in chromatogram, this could be attributed to the situation when the products formed do not absorb UV radiation [23]. The LC method was optimized to resolve degradation products from the drug that were formed in acid and alkaline settings promoted by heat.
3.1.3. Linearity
Linearity was established by least squares linear regression analysis of the calibration curve. The regression equation for lamotrigine was found by plotting peak area () versus the concentration () studied from 10.0 to 80.0 μgmL−1. The representative linear equation was , and the correlation coefficient () was highly significant. The validity of the assay was verified by analysis of variance (ANOVA), obtaining (; ) with no deviation from linearity ().
3.1.4. Precision
The precision results of the HPLC method demonstrated that the variability was low with CV (%) values ranging from 0.53 to 1.71 for intraday and 1.24 for interday precision. The CV values lower than 2% indicate the good precision of this method. At each level of the lamotrigine concentration, three determinations were performed.
3.1.5. Accuracy
At each level of lamotrigine concentration three determinations were performed. The mean recovery was (mean ± SD) , and . These values show the good accuracy of the proposed HPLC method.
3.1.6. Robustness
The robustness testing was performed in order to evaluate the susceptibility of measurements due to deliberate variations in analytical conditions [19, 23]. The changes in operational parameters did not lead to important changes in the performance of chromatographic system. The response determined in the robustness test is the percentage of the drug in relation to the nominal dose on tablet sample, and the CV% between them was 0.77. The robustness study has proved that in every employed condition, the chromatographic parameters agreed with established values and the assay data remained acceptable.
3.1.7. Sensitivity
The LOD value obtained with the signal-to-noise about 3.8 : 1 was in the concentration of 0.05 μgmL−1 of the drug. The LOQ value obtained with the signal-to-noise about 10 : 1 was in the concentration of 0.15 μgmL−1 of the drug. These results showed the good sensitivity of the method to determine and quantify lamotrigine.
3.1.8. System Suitability
System suitability was evaluated to verify if the chromatographic system was adequate for the analysis to be done. The approximate results were theoretical plates (), capacity factor (), peak asymmetry, or tailing factor (). The values for these parameters were satisfactory in accordance with the literature [28, 29].
3.1.9. Solution Stability
The solution evaluated demonstrated to be stable at least for 30 days in methanol and for 15 days in HCl 0.01 M.
3.2. UV Method
3.2.1. Selection of UV Conditions
The UV-VIS method is extensively used in quality control of pharmaceutical products due to the potential of the great majority of the drugs to absorb energy in these wavelengths. Lamotrigine presents a structure with aromatic rings, making the absorption in UV region possible. The method is fast, easy, of low cost and shows the advantage of not generating a lot of solvent discharges [30]. At first, different solvents like methanol, ethanol, 0.1 M HCl, and 0.01 M HCl were tested. The maximum absorption region in different solvents and their intensities could be determined by UV spectrophotometer. The lamotrigine solutions prepared with ethanol and methanol demonstrated maximum absorption in 307 nm and solutions prepared with HCl presented maximum absorption at 267 nm. After preliminary tests, the choice was the use of 0.01 M HCl. This solvent was evaluated for the development of the analytical method, in which the drug was shown stable during the studied period and presents the advantage of eliminating organic solvents in the analysis.
3.2.2. Specificity
The specificity determination is very important during the validation of nonchromatographic methods, since there is no step of separation before the determination [30, 31]. In pharmaceutical analysis, UV spectrophotometer can be a quantitative method when there is no interference of the inactive ingredients of the pharmaceutical formulation. The UV spectra obtained through the analysis of the placebo solution did not present any interference in the maximum of 267 nm of lamotrigine, demonstrating the specificity of the method. The spectrum is showed in Figure 5.
3.2.3. Linearity
Linearity for UV method was determined over the concentrations ranging of 5.0 and 40.0 μgmL−1, with significantly high value of correlation coefficient () and the linear regression equation . The validity of the assay was verified by means of the ANOVA. According to it, there is linear regression and there is no deviation from linearity ().
3.2.4. Precision
The precision experimental values obtained for UV method were for intraday ranging from 0.35 to 1.17 and 0.71 for interday precision. The results showed the low CV (%) and the good precision of this method.
3.2.5. Accuracy
The analytical accuracy is the nearness of the results obtained against the real values [30]. At each level of lamotrigine concentration, three determinations were performed. The results were expressed as percent recoveries and the means were 97,6, 98,9, and 99,4%. These values showed the good accuracy of the UV proposed method.
3.2.6. Robustness
The results of the experiments in the robustness test for UV method are expressed in percentage of the drug in relation to the nominal dose, calculated using a standard solution. The values obtained for different extraction procedures are demonstrated in Table 1. The validity of the assay was verified by means of the ANOVA. According to it, .
3.2.7. Sensitivity
The LOD and LOQ values mathematically obtained for UV method were 0.29 μgmL−1 and 0.88 μgmL−1, respectively.
3.3. Comparison between LC and UV Methods for Lamotrigine Determination
The comparison between the UV (; mean (%) ± SD) and the HPLC method (; mean (%) ± SD) was performed through the statistical -student test at 0.05 significant level of the mean experimental values obtained in the determination of lamotrigine in tablets by each method. The test did not show statistical difference between the two techniques ().
The LC method developed is very simple, and results confirm suitable accuracy, specificity, and precision. In this study, a HPLC and an UV method were developed and validated for the quantitative determination of lamotrigine in tablets. There is no significant difference between the validated LC method and UV method, suggesting that both can be interchangeable.
The authors wish to thank LEPCQ, LCQFar for technical support.
- F. D. Fuchs and L. Wannmacher, Farmacologia Clínica, Guanabara Koogan, Rio de Janeiro, Brazil, 2004.
- J. O. McNamara, Goodman & Gilmans: As Bases Farmacológicas da Terapêutica, McGraw Hill, Rio de Janeiro, Brazil, 2003.
- E. Ben-Menachem, "New antiepileptic drugs and non-pharmacological treatments," Current Opinion in Neurology, vol. 13, no. 2, pp. 165–170, 2000. View at Google Scholar
- C. L. Cheng, C. H. Chou, and O. Y. P. Hu, "Determination of lamotrigine in small volumes of plasma by high-performance liquid chromatography," Journal of Chromatography B, vol. 817, no. 2, pp. 199–206, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. Croci, A. Salmaggi, U. De Grazia, and G. Bernardi, "New high-performance liquid chromatographic method for plasma/serum analysis of lamotrigine," Therapeutic Drug Monitoring, vol. 23, no. 6, pp. 665–668, 2001. View at Publisher · View at Google Scholar · View at Scopus
- M. M. Castel-Branco, A. M. Almeida, A. C. Falcão, T. A. Macedo, M. M. Caramona, and F. G. Lopez, "Lamotrigine analysis in blood and brain by high-performance liquid chromatography," Journal of Chromatography B, vol. 755, no. 1-2, pp. 119–127, 2001. View at Publisher · View at Google Scholar · View at Scopus
- M. Torra, M. Rodamilans, S. Arroyo, and J. Corbella, "Optimized procedure for lamotrigine analysis in serum by high-performance liquid chromatography without interferences from other frequently coadministered anticonvulsants," Therapeutic Drug Monitoring, vol. 22, no. 5, pp. 621–625, 2000. View at Publisher · View at Google Scholar · View at Scopus
- N. R. Barbosa and A. F. Midio, "Validated high-performance liquid chromatographic method for the determination of lamotrigine in human plasma," Journal of Chromatography B, vol. 741, no. 2, pp. 289–293, 2000. View at Publisher · View at Google Scholar · View at Scopus
- Y. Bottiger, J. O. Svensson, and L. Stahle, "Lamotrigine drug interactions in a TDM material," Therapeutic Drug Monitoring, vol. 21, no. 2, pp. 171–174, 1999. View at Publisher · View at Google Scholar · View at Scopus
- E. Vidal, C. Pascual, and L. Pou, "Determination of lamotrigine in human serum by liquid chromatography," Journal of Chromatography B, vol. 736, no. 1-2, pp. 295–298, 1999. View at Publisher · View at Google Scholar · View at Scopus
- P. Angelis-Stoforidis, D. J. Morgan, T. J. O'Brien, and F. J. E. Vajda, "Determination of lamotrigine in human plasma by high-performance liquid chromatography," Journal of Chromatography B, vol. 727, no. 1-2, pp. 113–118, 1999. View at Publisher · View at Google Scholar · View at Scopus
- K. M. Matar, P. J. Nicholls, S. A. Bawazir, M. I. Al-Hassan, and A. Tekle, "A rapid liquid chromatographic method for the determination of lamotrigine in plasma," Journal of Pharmaceutical and Biomedical Analysis, vol. 17, no. 3, pp. 525–531, 1998. View at Publisher · View at Google Scholar · View at Scopus
- B. C. Sallustio and R. G. Morris, "High-performance liquid chromatography quantitation of plasma lamotrigine concentrations: application measuring trough concentrations in patients with epilepsy," Therapeutic Drug Monitoring, vol. 19, no. 6, pp. 688–693, 1997. View at Publisher · View at Google Scholar · View at Scopus
- M. Cociglio, R. Alric, and O. Bouvier, "Performance analysis of a reversed-phase liquid chromatographic assay of lamotrigine in plasma using solvent-demixing extraction," Journal of Chromatography, vol. 572, no. 1-2, pp. 269–276, 1991. View at Publisher · View at Google Scholar · View at Scopus
- S. M. Addolorata, B. Francesca, C. Matteo, A. Mario, and M. A. Raggi, "Rapid HPLC analysis of the antiepileptic lamotrigine and its metabolites in human plasma," Journal of Separation Science, vol. 30, no. 14, pp. 2249–2255, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Bompadre, A. Tagliabracci, M. Battino, and R. Giorgetti, "Determination of lamotrigine in whole blood with on line solid phase extraction," Journal of Chromatography B, vol. 863, no. 1, pp. 177–180, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- E. Griner-Sosanko, D. R. Lower, M. A. Virji, and M. D. Krasowski, "Simultaneous determination of lamotrigine, zonisamide and carbamazepine in human plasma by high-performance liquid chromatography," Biomedical Chromatography, vol. 21, no. 3, pp. 225–228, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. Emami, N. Ghassami, and F. Ahmadi, "Development and validation of a new HPLC method for determination of lamotrigine and related compounds in tablet formulations," Journal of Pharmaceutical and Biomedical Analysis, vol. 40, no. 4, pp. 999–1005, 2006. View at Publisher · View at Google Scholar · View at PubMed
- N. F. Youssef and E. A. Taha, "Development and validation of spectrophotometric, TLC and HPLC methods for the determination of lamotrigine in presence of its impurity," Chemical and Pharmaceutical Bulletin, vol. 55, no. 4, pp. 541–545, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. Pollisetty, M. Khagga, R. R. Buchi, and S. S. V. Koduvi, "Development of a validated stability indicating LC method for lamotrigine," Chromatographia, vol. 70, no. 1-2, pp. 271–276, 2009. View at Publisher · View at Google Scholar · View at Scopus
- International Conference on Harmonization (ICH), "Validation of Analytical Procedures: Validation of Analytical Procedures: methodology Q2B," Consensus Guideline, November 1996.
- British Pharmacopoeia 2005, Not Avail, London, UK, 2005.
- United States Pharmacopeia, USP Convention, Rockville, Md, USA, 2008.
- S. Klick, P. G. Muijselaar, J. Waterval et al., "Toward a generic approach for: Stress testing of drug substances and drug products," Pharmaceutical Technology, vol. 29, no. 2, pp. 48–66, 2005. View at Google Scholar · View at Scopus
- Proceedings of the International Conference on Harmonization (ICH), Stability Testing of New Drug Substance and Products: Methodology Q1A(R2), 2003.
- Proceedings of the International Conference on Harmonization (ICH), Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2 (R1), 2005.
- M. Bakshi and S. Singh, "Development of validated stability-indicating assay methods—critical review," Journal of Pharmaceutical and Biomedical Analysis, vol. 28, no. 6, pp. 1011–1040, 2002. View at Publisher · View at Google Scholar · View at Scopus
- R. L. Snyder, J. Kirkland, and L. Glajch, Pratical HPLC Method Development, Jonh Wiley & Sons, Hoboken, NY, USA, 1997.
- G. A. Shabir, "Validation of high-performance liquid chromatography methods for pharmaceutical analysis: understanding the differences and similarities between validation requirements of the US Food and Drug Administration, the US Pharmacopeia and the International Conference on Harmonization," Journal of Chromatography A, vol. 987, no. 1-2, pp. 57–66, 2003. View at Publisher · View at Google Scholar · View at Scopus
- FDA, Center for Drug Evaluation and Research. Reviewer Guidance: Validation of Chromatographic Methods, Rockville, Md, USA, 1994.
- H. G. Brittain, "Validação de métodos não-cromatográficos," Pharmaceutical Technology, vol. 2, no. 3, p. 4, 1998. View at Google Scholar


text:
I am only just learning pointers and finding them quite difficult. When I try to compile I get pointers.c:18: error: expected ';', ',' or ')' before '&' token. I am not to sure what this means.
Is it ok for me to do this?
int alpha;
void getAlpha(int &alpha)
.... rest of code.
Sorry if this doesn't make sense

subset: commoncrawl


text:
- Home
- Artificial Landscape Rocks
- Insulated Pouches for Artificial Rocks
- Insulated Pouch (34"W x 24"H)
Insulated Pouch (34"W x 24"H)
Insulated Pouch (34"W x 24"H)
Product Description
Cold weather areas can require insulation for pipes pumps or other utilities. All of our insulated pouches and rings now have built-in grommets making it easy to secure around pressure tanks irrigation pipes or pumps. Pouch can be placed over pipes to protect from the cold. Two years UV protection when used without an enclosure.
- Compatible with our Rock enclosure AR612
- Dimensions: 34"W x 24"H
- 2 Color Options: Green or Desert Tan


text:
Tristar Products Inc.
Direct Response marketing companies news. Information on Tristar Products product branding and marketing strategies including information on commercials, ads and overall branding strategies.
| Article
Cover Story: Product Power 1 Sep, 2017
| Article
The Stars Align! 1 Oct, 2014
| Article
Just the Right Blend 1 Oct, 2013
| General Info
2012 DRMA MOY Nominee - Tristar Products 1 Aug, 2012
©2017 Questex, LLC. All rights reserved. Reproduction in whole or in part is prohibited. Please send any technical comments or questions to our webmaster. Contact Us | Terms of Use | Privacy Policy |


text:
So I just finished watching the first 65 minutes or so of the debate, and here are my thoughts,
1. This was the character Romney should have been playing all along - Romney at his best is a less affable and empathic (but more personally decent) Bill Clinton. A big part of Clinton's appeal is his ability to talk policy in ways that relate to people's lives. Romney is the guy who studies hard, knows his facts, and is focused on results. So when Romney shows that he is using his big brain and formidable work ethic to explain policies that benefit the public, he comes off as reassuring and somewhat likeable. When Romney tries to become likeable by avoiding policy issues, he comes across as phony and condescending. The smart, policy-focused Romney is the most likeable Romney that is going to come across on television. Hopefully that lesson has sunk in. The more Romney talks about the issues, the better off he is.
2. The big lesson of this cycle's debates: Stop underestimating the intelligence of the American public - Looking at the post-debate polls, the Romney that showed up at the debate made a much better impression than the "humanized" Romney of the Republican convention. Why did they like yesterday's Romney? Probably for the same reason Republican primary voters ultimately liked Romney's primary debate performances more than Michelle Bachmann's and Herman Cain's. The lesson of this debating season is that if you have a plausible explanation for our circumstances, have proposals that connect to people's lives, and can defend your proposals, people tend to like it. Having substance and making an effort to communicate that substance works a lot better than Cain's 9-9-9, or Gingrich's moon colonies, or Romney's convention story about roses or Obama's trying to skate through yesterday's debate on smugness. I'm not saying that the American public is some kind of Brookings Institution seminar audience. Obama and Romney would both probably have gotten failing graded from such a crowd. I am saying that the public is smarter and more interested in the candidates showing issue mastery than the campaigns seem to think. It's not for nothing that the two best received remarks of the general election season have been Bill Clinton's Democratic convention speech and Romney debate performance.
3. The prevent defense is still for losers - Obama wanted the debate to be a nonevent. He spent the first part of the debate trying to make the debate a low key affair of two guys with Obama having slightly better ideas. The result that Obama was just incredibly boring for the first fifteen minutes or so. I would hear two sentences of Obama and if I didn't force myself to focus, I started hearing Charlie Brown's teacher. I think that may have been partly intentional on Obama's part. The problem was that Romney didn't play along and by the time Obama realized Romney was getting in some hits, much of the damage was done. I think Obama wishes he had tried to turn it into a slugfest.
4. Time - I haven't seem all of the debate but Obama seems to be doing more of the talking and Jim Lehrer is forever trying to shut Romney up.
5. Finally a mention Of IPAB by Romney - I thought Romney did very well on Medicare, but he left a few points on the field in regard to Obama's centralized rationing board. It wasn't totally clear that Romney is for a defined Medicare benefit to go along with competitive bidding.
6. Nobody is rope-a-doping anybody - Romney didn't give a bad convention speech and have a lousy September in order to lull Obama into a false sense of security. Romney just picked a bad strategy for a while. Obama didn't look bad yesterday as part of master plan to destroy Romney in later debates. He just ran into a better opponent than he expected and running out the clock was the wrong answer on that night. What both of them are doing is very hard.


text:
There is an interesting name to take heed to this year aside from the other marquee rhymers everyone is pegging for greatness at the moment. Yep, don't look now but Killa Kyleon is slowly crafting a nice auroa around his name. I think we can all agree his showing on K.R.I.T.'s "Moon & Stars (Remix)" was beyond impressive and this time he comes back solo with the CyFyre produced "Get Rich Or Die Trying." Consider this highway music as it's smooth as baby skin and an easy listen as Killa and Yung Chill effortlessly explain the importance of the paper chase by any means necessary.
Ashley Outrageous' The Playlist Vol. 2 looks to be turning into quite the release, doesn't it? This and the Smoke DZA track from yesterday officially have me interested.[audio:http://www.archive.org/download/KillaKyleon-getRichOrDieTrying/KillaKyleon-GetRichOrDieTryingprod.ByCyfyre.mp3%5D
Killa Kyleon Feat. Yung Chill – "Get Rich Or Die Trying"
Respect: AO
The Houston Texan also took his talents to Weezy and Boi-1da's banger "Bill Gates," which also made TSS' year end list.


text:
The creative team behind Guardians of the Galaxy took to Facebook this morning in order to answer fan questions before posting the official second trailer for the highly anticpated foray into the cosmic side of the Marvel Cinematic Universe. In all, the Q&A featured Chris Pratt (Starlord), Dave Bautista (Drax the Destroyer), Vin Diesel (Groot) Karen Gillan (Nebula), Director James Gunn, and Marvel Studios President & Producer Kevin Feige.
Below are the highlights from the Q&A. For all the questions and answers, be sure to check out the Guardians of the Galaxy Facebook page linked below.
For Dave Bautista: Do you now prefer drax's tattoo's over your own?
Dave Bautista: Drax's tattoos are way cooler than mine, but the similarity is that both of our tattoos tell our life stories.
If/when Marvel gives the go-ahead for a sequel, would you be willing to revisit Guardians as the director?
James Gunn: I believe I am contractually obliged to do that whether I want to or not. But, of course, I'd love it. I love these guys so much - the guys at Marvel and the cast. They've become very close friends.
Given his history in comedy, James Gunn, why was Chris Pratt the right guy to be Star Lord?
James Gunn: It's difficult to say what casting is like, but when someone fulfills a role completely, becomes a character, and even goes beyond what you originally expected, you just know. I don't know if I believe in true love and soul mates, but I do believe certain roles have soul mates, and Star-Lord and Chris are soul mates.
James Gunn, Are there going to be appearances by any of the other Guardians of the Galaxy from the Abnett/Lanning run without going into specifics? Either way, this movie looks rad.
James Gunn: Maybe sorta.
Will we get Starlord's origin told?
James Gunn: We get a large part of Star-Lord's origin. But there is always more to give up.
Will the movie be connected with any episode of Agents of S.H.I.E.D?
James Gunn: Maybe.
How do you even begin to create the vision for the production design for something like this? Did you have free reign to hire the designers you wanted?
James Gunn: Yes, I did. Charlie Wood, our production designer, was one of my primary partners on this film. We started with long long discussions, lots of photos, and my love of the artist Chris Foss - who we actually hired to work on the movie. He's a classic science fiction artist from the 70s and 80s.
I've loved the posters so far, especially the latest one. But any chance of a "villains" poster, as well?
James Gunn: There is indeed a chance of that and more. Bring on Yondu!!
Was their any kind of specific influence when shooting this movie?
James Gunn: So many. One of the biggest influences was - and no one is going to expect this answer - Magritte's Empire of Light paintings. I was also very influenced by many of the great space epics and science fiction films AND westerns like the films of Sergio Leone. Not to mention of course the comics, especially Abnett and Lanning and Jim Starlin.
James Gunn why couldn't the movie be any longer? Did you film everything you really wanted to?
James Gunn: Yes. The movie is just what I want it to be.
For James and Kevin: Was there ever a time when you had very opposing visions on a scene or character and how did you resolve that issue?
James Gunn: Every day. But the great thing about Kevin and me working together is that neither one of us have big egos about what we're doing. What's important is always creating the best movie possible, not getting what we want just because we think we're right. The truth is we agree 99% of the time. Those times that we don't, we talk about it, argue about it. Usually one of us wins the argument (our editors Fred Raskin and Craig Wood are often a part of these arguments). In those times no one wins we screen both versions and see what the audiences think. But, again, this has been over relatively minor stuff. Also, I trust Kevin on a lot of big issues and I think he trusts me a lot when it comes to comedy and character stuff. It's a really fun and enlivening partnership.
James there is so much great work you have done in the past. What was the factor that enticed you to take on Guardians?
James Gunn: I love raccoons, Marvel comics, and space operas. How could I pass this up? When would I give another chance. At one point in time our producers Jeremy Latcham and Jonathan Scwartz thought I was biologically engineered to make this movie. It's everything I love.
Is there going to be any mention of Drax's past in the movie or Rocket's adventures on Halfworld? Or even better if the Hulk has had interaction with Rocket before like in the comics?
James Gunn: We find out a little about their pasts. No Hulk in this movie, sorry.
To Kevin or James Gunn: For us fans of the original guardians can we expect anything else cool beyond Yondu (easter egg or otherwise)?
James Gunn: Easter egg wise, yes.
To Kevin Feige: In the Guardians of the Galaxy's film will have some easter egg from the Avengers 2 or 3 films?
Kevin Feige: Yes.
Is there a final cut? If so, how long is the movie?
James Gunn: The movie is very very close to final. We're around two hours long.
For Chris Pratt - What's Starlord's equipment like? Does he use the Elemental Gun? Can you keep it?
Chris Pratt: Yes. It's not the exact elemental gun that you see in the comics but it's close. His gun is awesome. Two great blasters and they are amazing and sadly they did not let me keep one but the next time i see one I'm going to steal it.


text:
7720 Katy Freeway @ Silber Rd next to IKEA
Directions Houston, TX 77024
Contact Your local Houston Dodge Chrysler Jeep Ram Dealership
When you visit Helfman, Texas' Largest Houston Dodge Chrysler Jeep Ram Dealerships you will experience the world class service of a knowledgeable and experienced staff. Come see us in person at 7720 Katy Freeway @ Silber Rd next to IKEA @ Silber Rd next to IKEA and Test Drive the newest Dodge Chrysler Jeep Ram Vehicles & browse a very large Inventory of Preowned Used Cars for sale in Houston. Get your personalized car price quotes, find convenience in scheduling automotive Repair Services. Experience our Parts Department, Expert Staff whom are Trained and Certified to assist you in your Auto Parts selection. We offer more Auto Finance and Vehicle Lease Options, check out Our Specials, Military Discounts and Specials, get more Money for your Trade In at Helfman your local Houston Car Dealership serving Houston, Northwest, Clear Lake, Spring, Gulfgate, Port Arthur, Beaumont, Katy to Galveston.
We offer Convenience, Selection, Savings, and our Best Car Prices direct on our website. Look at our vehicle inventory, when you find the vehicle you like, set up a test drive by contacting our friendly sales staff or submitting a short form on our inventory details pages/Contact us form.
We know there are many choices when it comes to a Car Shopping websites for where to find cars and buy cars. We would like to say thank you for allow us to help you shop and find the perfect vehicle and to trust us with your Auto Service in Houston Texas and Northwest, Clear Lake, Spring, Gulfgate, Port Arthur, Beaumont, Katy to Galveston.Dodge Chrysler Jeep Ram Sales
Imagine driving a stylish and sporty Dodge Chrysler Jeep Ram in Houston to your driveway by this afternoon! Helfman Dodge Chrysler Jeep Ram has the inventory to get you into the perfect vehicle and on the road. Our Dodge Chrysler Jeep Ram car dealership is stocked with all of the latest Dodge Chrysler Jeep Ram models. Get a great deal on a Dodge Chrysler Jeep Ram in Houston TX by calling or visiting Helfman Dodge Chrysler Jeep Ram in person.
New Dodge in Houston
Dodge Avenger, Caliber, Challenger, Charger, Grand Caravan, Journey, Viper, Nitro, Durango
Helfman Dodge is a great place to look for your new Dodge in the Houston, Katy, Spring, Gulfgate Texas Areas.
New Ram Truck in Houston
Ram 1500, 2500, 3500, Chassis Cab, C/V Tradesman, ProMaster
Helfman Ram is a great place to look for your new Ram in the Houston, Katy, Spring, Gulfgate Texas Areas.
New Chrysler in Houston
Chrysler Town & Country, 200, 300
Helfman Chrysler is a great place to look for your new Chrysler in the Houston, Katy, Spring, Gulfgate Texas Areas.
New Jeep in Houston
Jeep Patriot, Grand Cherokee, Wrangler, Wrangler Unlimited, Compass, Liberty
Helfman Jeep is a great place to look for your new Jeep in the Houston, Katy, Spring, Gulfgate Texas Areas.
When it comes to Car Shopping for high quality and competitively priced used cars locally in Houston, Helfman Dodge Chrysler Jeep Ram is your destination/used car dealership. We maintain a huge selection of used cars produced by today's top auto manufacturers and from sources such as 'cars for sale by owner' and 'trade ins'. You want to buy a used car in Houston that has been through a highly detailed inspection by our auto technicians and will run like new for many years to come.
Our finance department is here to simplify the process of getting a car loan in Houston. We work with multiple financial institutions to secure your low interest car loan. Start the car loan process online by completing our secure online finance application.
Get Dodge Chrysler Jeep Ram Service and car repair from the folks you can trust at Helfman Dodge Chrysler Jeep Ram. There's a reason why we are a preferred destination for repairs and service for so many around Houston. It's because of our superior service, trained mechanics. * We also have free Wi-Fi in our service waiting area for your convenience and more. Visit us at 7720 Katy Freeway @ Silber Rd next to IKEA @ Silber Rd next to IKEA, Houston, Harris County, Texas and join the thousands who already rely on us for their automotive needs.
Multi-million dollar Dodge Chrysler Jeep Ram car parts inventory, Factory Direct Genuine OEM Mopar Parts for your Dodge Chrysler Jeep Ram Auto Parts and Accessories; engineered to fit your car, oil filters, spark plugs, belts, brakes, tires, batteries, exhaust system, ignition, shocks, struts, radio, DVD Players and more.
Auto body repair, collision damage repairs, full car painting, dent removal, cosmetic repair & refinishing, restoration, lease vehicle touch up, fleet services, back to showroom condition.


text:
CHARLTON boss Chris Powell heaped the praise on Ricardo Fuller after the striker's sublime goal set his side on their way to three points against Peterborough.
Bottom-of-the-table Peterborough had been the better side before Fuller struck 13 minutes from the final whistle with the returning Yann Kermorgant wrapping things up late on.
But it wasn't all cheers for Powell as Fuller went down clutching his hamstring having fired the Addicks ahead and he is now a big doubt for Saturday's derby at Millwall.
"We certainly needed something like that to break the deadlock," said Powell.
"It is part of the reason I brought a player like him to the club, a player that is a bit of a maverick talent.
"He's quite special when he gets the ball to his feet, he doesn't score many like that though, usually they come from mazy dribbles but it was a superb goal and it came at a crucial time because Peterborough were definitely in the ascendancy.
"It needed something like that to break the deadlock."
He added: "Ricardo felt his hamstring again.
"It's the story of our season so far, but we'll monitor him and hopefully it will settle down.
"I don't think it has completely gone but he's had problems in that area this season and we've got to do our best to make sure we get him out on that pitch more often than not."
Peterborough will consider themselves hard done by to come out of the game with nothing and Powell acknowledged the visitors had played well.
The Valley chief said: "Peterborough definitely played their part.
"It doesn't matter where you are in the Championship table, any team can perform and they performed very well.
"Obviously they're down there for a reason and maybe it's because they don't have that real cutting edge.
"But their approach play was very good, they have good principles but of course you've got to win the game and that's why we're out there.
"As managers you live and die by your results.
"Once we went 1-0 up the game was a bit more stretched and we got the second goal, which was very well worked, and a clean sheet too was good.
"There's going to be times where we're going to play better and not get much in return, so I'll definitely take this.
"We've played better this year and lost."
The victory was Charlton's fourth in five matches and with neighbours Millwall currently on a 12-match unbeaten run, Saturday promises to be a real battle.
Powell said: "We've lost one game in the last eight and we're playing against a team that are really in a good place.
"We've done particularly well away from home this year and I'll be looking for us to carry that on in a place that will test you on and off the field.
"It will test your physical and mental capabilities but that's why we're in this game.
"I'm looking forward to it and I'm sure it will be a real good local London derby."
But Charlton will have to face the rampant Lions without ever-present centre-half Michael Morrison, who picked up his fifth booking of the season on Tuesday evening.
Powell couldn't hide his disappointment with the news, but admitted it opens a window for another one of his defenders to impress.
He conceded: "It's a shame because I think he's done particularly well this season and did well under pressure from a lot of approach play from Peterborough.
"I thought he made some good timely interceptions and tackles and it's a shame.
"But that's why you have the squad.
"I've got Matt Taylor and Dorian Dervite who both want to play and sometimes you get an opportunity through someone else's misfortune, whether that's through injury or suspension, as it is in this case.
"It has happened so often this year with injuries and now someone gets an opportunity in what is a huge game against a team that are definitely in form.
"It's a local derby and we need to make sure that we're ready for it."
Follow us on Twitter @NewsShopperSprt


text:
Ask a Mechanic Online and Get Answers to Your Car Questions
Welcome to Justanswer, My name isXXXXX am here to help.
If the plugs are fouling out then there is definately a problem with the running condition of the vehicle, The first thing I would check is the compression if the rings are weak this can cause very quick fouling of the plugs
The other thing is the Oxygen sensors this will make the vehicle run lean or rich fouling out the plugs
I would run seafoam through the engine then check those two things if the problem is still happening then try a different set of plugs which are colder than these ones
Let me know if you have any questions. If this was helpful please take a moment to kindly press the green ACCEPT button in the lower right hand corner. Thanks in advance Danny
Let me know if you have any questions. If this was helpful please take a moment to kindly press the green ACCEPT button in the lower right hand corner. Thanks in advance Danny
you didn't say anything about plug wires.
You didn't explain what an extender id.
The plug wires are not going to foul out the plugs
Extender is not going to help at all
If the plugs are getting fouled out then its the combustion of the engine running not anything to do with the location
A bad plug wire will not foul out the plug?
If the plug wire is not firing the cylinder at all this will cause it to get wet
But the problem is your stating the plugs are fouling out
Then you need to get to the source of the problem. You can check the wires to ensure they are giving off a nice spark at each one but normally when this happens the car is always going to be missing on a cylinder even with the new plugs
If the car has constant misfiring then I would change the plug wires and check the coil operation
Ok Thanks. I was haveing to text this info to my son. That took extra time on both of our parts. You did a fime job.


text:
Would you suggest gum reducing surgery, and then crowns/veeners? I have some bonding now, that is chipped and dis-coloring. Is a gum lift/grafting a smart choice before veeners/crowns?
I Hate my Gummy Smile, Should I Have Gum Reduction Surgery Before Getting Crowns/Veneers? (photo)
Doctor Answers 7
Gummy Smile Correction, Then Veeners
Gummy smile
Good luck!
A "gum lift" would improve your smile
Great question! You must have already done some research to realize that a "gum tissue lift" would greatly improve the esthetics of your smile since there is currently an excessive gum tissue display. There are a few different options available, but you need to find a dentist with advanced training in cosmetics to best determine the type of gum tissue surgery that is needed. A detailed exam including x-rays and photos will be needed. Many times gum tissue procedures can be done with lasers. Other times, people are referred to a periodontist for the gum tissue procedure.
To answer your second question, yes you should definitely have the gum tissue lift done before the crowns and veneers. That is the best way to ensure a beautiful result because then the crowns and veneers can be the ideal shape and size for you.
You might also like...
Laser gum re shaping, use a safe laser!
In fact, ask to see pictures of cases that the cosmetic dentist and periodontist have completed.
Then you can you see what you might expect to look like after your treatment.
Gummy Smile
I would be cautious in your case. It looks like you have a lot of gum in your smile. Typically, gum can only safely be raised by 2-3 mm. THe gums should then be allowed to heal for many weeks before the veneers. THere may be a refinement surgery necessary. The gum lift surgery may get you close enough to where you want to be. The other more dramatic solution is upper Jaw surgery where the upper jaw is impacted up - this is more indicated when there is 6 or more mm of excess gumminess. We call the condition vertical maxillary excess - VME. Make sure you get a few consultations an clearly communicate your expectations. Make sure you see before and after photos of the doctor's own work that is specifically applicable to you. THese types of cases are often botched. Do not do the laser crown lengthening. I do it myself and it is for mild cases only. You need full surgical crown lengthening
Gum Surgery is done Before Crowns/Veneers
Ideally you always want to do gum surgery (elective or not) before you do your crowns and veneers. In the front of your mouth this may mean waiting 4-8 weeks for final healing prior to starting the dental work. I find a laser to be much gentler to the gums and results in speedier healing. Sometimes this is not possible. It is very important that you are using an experienced Dentist & possibly Periodontist team. You will need x-rays and a thorough checking of your bone height and gum health prior to starting. The Cosmetics with a "gum lift' in the right hands can be quite stunning. Good Luck.
Gummy Smile...Gum Reduction before veneers or crowns?
You would first start with the appearance of a gummy smile that you dislike. I would use waterlase laser on a tooth by tooth basis and remove portions of the bone material and gum tissue, thereby exposing more of the tooth structure.Then the crown lengthening and gingival trimming would be monitored very closely to assure a perfect match for each new veneer that was to be placed on the tooth.The final cosmetic result should show a harnony and symmetrical balance between the amount of gum showing and the the length of the tooth to create a natural beautiful smile. Make sure you find a dentist who uses laser technology to do the gum reduction! Good luck and enjoy a beautiful new smile!
These answers are for educational purposes and should not be relied upon as a substitute for medical advice you may receive from your physician. If you have a medical emergency, please call 911. These answers do not constitute or initiate a patient/doctor relationship.


text:
Join Liz Nolan as she visits the chronicles of this passionate and spectacular art.
Each week an opera, a story, a glimpse into the lives of the characters, both real and imaginary, who have shaped the form as we know it today.
Sweet bird of youth- The Swallow, or La Rondine, is Puccini's poignant tale of a courtesan who yearns to escape her gilded cage, and fly into the arms of her beloved.
Kiri Te Kanawa and Placido Domingo star in a great recording under Lorin Maazel.
RTÉ lyric fm, Sunday 28 April, 7pm-8pm


text:
|If you like my books, essays, etc. you might want to put your name on this private email list (no spam ever) for advance notices, coupons, and occasional freebies. Tell your friends too! Books Leaving Footprints Newsletter. Previous gifts include a short story, a poem and a half-off coupon for the newest book. Sign up, and don't miss out!"
Thursday, January 29, 2009
Where the Deer Rest
Today we surprised a couple of deer again. I don't have a lens on the digital camera that can get a very good picture, but you can see two of them racing away across the top of the hill.
Here is the kind of track I usually see on my walks, just where one single deer strolled, or ran, through the snow. This pathway was made by one deer. Almost every day the trails are new. We either get a light dusting of snow that softens the old ones, or more likely, the wind blows and smooths the surface over entirely.
But the other day when I walked over to the son's trailer, I found where those deer in the top picture are running to whenever I scare them up from their munching on remnants of grain from the local farm co-op next door. That's the space-station looking thing just over the hill in the next picture.
Here you can see a very much trodden down path. It's so wide and compacted that you might think it's one that I've been snowshoeing. But it is all from multiple deer walking it, over and over. When I turn around in this same spot, I see where the deer have been hanging out to rest and find protection from the weather. They have trampled most of the area under a grove of cedars. I let Maggie stay in the picture so that it gives a sense of the proportion.
4 comments:
- rainfield61 said...
When the deer run, the track is a single line, I assume, base on the picture and your description. When the deer walks, am I going to see 2 parallel lines or ... ?
- January 30, 2009 at 3:58 AM
- Sharkbytes (TM) said...
Oh dear, I haven't explained it very well then. I will try to get some good pictures of deer tracks. The snow is too fluffy today (we had several more inches last night again), but you've given me a good assignment.
A single track might be walking or running... the spacing will tell, but yes, one deer will make two parallel lines if the snow is fluffy-deep enough that it wasn't lifting its feet above the surface.
- January 30, 2009 at 9:06 AM
- Ratty said...
I don't know how I missed this one before. I've been tired the last few days. I really, really love the picture of the running deer! I don't think there is an open enough area near me to see them run very clearly. I only saw them do it one time, but they were quickly out of sight. There must be quite a few deer near you, with all of the tracks in the bottom photo.
- February 1, 2009 at 12:31 AM
- Sharkbytes said...
There is a herd- I counted 16 one day- that hang out near the grain elevator. They dump the dregs of the trucks in the field so of course it's always being pawed and trampled by the deer to get the grain.
- February 1, 2009 at 11:42 PM


text:
LearnHindiwith Us!Start Learning!
The national anthem is called राष्ट्रगान (Rastryagaan). जन गण मन (Jana Gana Mana) is the national anthem of India. It was written by Nobel laureate Rabindranath Tagore in 1911 and in the same year, it was sung for the first time by Indian National Congress (A political party). After Independence of India from British rule, it was officially adopted by the Constituent Assembly as the Indian national anthem on 24 January 1950.
Although, it was written in Bengali with heavy use of Sanskrit words, it was adopted in Hindi as it was originated also from Sanskrit and thus, shares many Sanskrit words. The national anthem of India consists of 5 stanza must take approximately 52 seconds.
Devanagari Script:
जन गण मन अधिनायक जय हे
भारत भाग्यविधाता
पंजाब सिन्धु गुजरात मराठा
द्राविड़ उत्कल बंगा
विन्ध्य हिमाचल यमुना गंगा
उच्छल जलधि तरंगा
तव शुभ नामे जागे
तव शुभ आशीष मागे
गाहे तव जयगाथा
जन गण मंगलदायक जय हे
भारत भाग्यविधाता
जय हे, जय हे, जय हे
जय जय जय जय हे!
Romanized Hindi:
Jana-gana-mana-adhinayaka, jaya he
Tava shubha name jage,
Tava shubha asisa mange,
Gahe tava jaya gatha,
Jana-gana-mangala-dayaka jaya he
Jaya he, jaya he, jaya he,
Jaya jaya jaya, jaya he!
English Translation:
Thou art the ruler of the minds of all people,
Dispenser of India's destiny.
Thy name rouses the hearts of Punjab, Shindhu,
Gujarat and Maratha,
Of the Dravida and Orissa and Bangla;
It echoes in the hills of the Vindhyas and Himalayas,
mingles in the music of Yamuna and Ganges and is
chanted by the waves of the Indian Ocean.
They pray for thy blessings and sing thy praise.
The saving of all people waits in thy hand,
Thou dispenser of India's destiny.
victory forever.
Great post about our National Anthem. Thanks for sharing.
Thanks, but what about the other 4 stanzas out of 5??.Awaiting egerly
can i have meaning of national anthem in hindi not in english.
why is it that there is only one stanza out of 5 pls write the other four in hindi 2
Hi All,
This is 2nd stanza..
Aharaha tava ahwaan Bhaan prachaarita,
Sunithav udhaar vaani
Hindu Bauddh Shikh Jain Parashikh,
Musalmaan Christaani
Purav pashchim aashey,
Tava sinhaasan paashey
Premhaar hoy gaathaa
Jana gana iky vidhaayako jaya he,
Bharata bhaagya vidhaata
Jaya he jaya he jaya he Jaya jaya jaya jaya he.
3rd stanza…
Pathana abhbhudhay bandhur panthaa,
Yuga Yuga dhaavith Daathri
Hey chirsaarathi, tava ratha chakre,
Mukhurith patha din raatri
Daaruna viplav maajhey,
Tava shankhadhwani baajey
Sankata dukkho traatha
Jana gana patha parichaayak jaya hey,
Bharata bhaagya vidhaata
Jaya he jaya he jaya he Jaya jaya jaya jaya he.
Ghor timir ghan nivir nishithey,
Peedith murchhith deshey
Jagrath chil thav avichala mangala,
Natanaya ney animeshey
Duhswapney aatanke,
Rakshaa kariley ankey
Snehamai tumhi maataa
Jana Gana Duhkh Thrayaka jaya hey,
Bharata bhaagya vidhaatha
Jaya he jaya he jaya he Jaya jaya jaya jaya he
5 th..
Raatri prabhatil udila rabichhabi,
Purva udaya giri bhaaley
Gaahey vihangam punya sameeran,
Nava jivano rass dhaley
Thava karunaaruna ragey,
Nidritha bhaarat jagey
Tava charane nath maatha
Jayo Jayo Jayo Hey, Jaya Rajeshwar
Bharata bhaagya vidhaata
Jaya he jaya he jaya he Jaya jaya jaya jaya he.
koi mujhe ye btaega ki ye humara national anthem kyo hai ??? Ye song gorge pancham k liye Wlcm song tha… Matlab Isme Gorge Pancham ko bharat ka Bhagya Vidhata btaya gya h jo ki bilkul galat h… Koi Foreigner humare bharat ka Bhagya Vidhata kese ho sakta h…. ???
vikash singh:
what is meaning of national anthem of india in word to word. please reply me anyone at firstname.lastname@example.com
thankyou paancho stanzas ke meaning btane ke liye
Piyushraj Keshaw:
Its my favorite song
Its my favorit song
भारत माता की जय ……..
I will salute always, if I'm hearing the song
super machi
I want meaning of all 5 stanzas in hindi
saniya yadav:
Salute to Rabindranath tagore and you all
sujal raj:
super post


text:
New Year's Eve at The District
New Year's Eve at The District
Additional Information
Music from Avian and Nick Thomas from The Spill Canvas and a special DJ set from Wes Eisenhauer of Soulcrate. Elisabeth Hunstad also will perform in the lounge beginning at 8 p.m. The evening also will include giveaways, signature food and drink specials and champagne. The event is free and is an all ages show.


text:
I have read through the old posts about vent-a-hood, but does anyone have anything to say about the newer models?
What is the current wisdom about the VAH is it worth the money or can you recommend something else?
My hood will be 60" and going over two 30" GE monogram ranges installed side by side.
Any advice or experiences are appreciated.


text:
Still King of the Slates
Thanks to the states new term-limit laws, this Junes election will give L.A.s African-American community its first taste of competitive politics in decades. But political operator and onetime Assemblyman Willard H. Murray Jr. casts a long shadow over the Crenshaw District: With two open seats in the California Legislature, the question is, will Murray continue to dominate?
The race for the 26th state Senate seat, being vacated this year by popular 20-year incumbent Diane Watson, features Murrays son, Assemblyman Kevin Murray, 38 years old, against Marguerite Archie-Hudson, a former assemblywoman and protégé of former Assembly Speaker Willie Brown. Kevin Murray, in turn, is leaving his 47th Assembly District to an even more hotly contested campaign between Samuel J. "Joey" Hill Jr., Murrays current chief of staff, and the well-connected newcomer Herb Wesson. In these heavily Democratic districts, which stretch along Interstate 10 from the Harbor Freeway to Culver City, and from the Fairfax district to Manchester Boulevard, slate mailers and endorsements have often been decisive and Willard Murray built his career as the "slate-mail king" of South-Central, gaining control over the doorknob slate cards that thousands of voters traditionally take with them into the polling booth. The family slate-mail operation, United Democratic Campaign Committee, could prove a trump card in both races. Moreover, Representative Maxine Waters is sponsoring her own mailer and her slate touts Kevin Murray. Which makes Archie-Hudson something of a longshot, despite a solid reputation and years of political experience. Educated at Harvard University, Archie-Hudson cut her political teeth during the 1980s on the staff of county Supervisor Yvonne Brathwaite Burke and running Willie Browns Southern California operation. Between 1990 and 1996, Archie-Hudson represented the 48th Assembly District in Sacramento, becoming chair of the Higher Education Committee and eventually being named Democratic whip. Archie-Hudson also achieved what Murray hoped to but could not: She was selected to serve on the prestigious Democratic National Committee. But Murray is the heavy in this race. Articulate and confident even cocky Murray is a former entertainment lawyer who was groomed for politics under his fathers worldly tutelage. First elected in 1994, he ascended to the chair of the powerful Assembly Transportation Committee, and in a bold move, launched a dark-horse campaign for the speakership in just his second term. In the meantime, his colleagues made him chair of the Legislatures African-American Caucus. "There is a void of leadership in the African-American community," says Dermot Givens, Murrays campaign manager. "Kevin Murray wants to fill that void." Both Murray and Archie-Hudson are traditional liberals, and differ little over policy. The candidates agree along the lines of an apparent emerging statewide consensus on the priorities of investing in education, addressing health-care reform and fixing the states infrastructure. Without issues to run on, Murray is stressing his personal intimacy with the area. He was raised in View Park, and contends that a life spent inside the 26th distinguishes him from his opponent. "Iam
this district," Murray told theWeekly
. "I grew up in this district, and I understand it. People know that." And while Archie-Hudson has herself represented portions of the district, shes pushing the question of character. Her political mail highlights a record of service, and asserts, "We know her. We can trust her." Its a point on which Murray is vulnerable. Murray was the subject of a sweeping ethics investigation by the states Fair Political Practices Commission in 1996. The probe resulted in a commission complaint against Murray, his father and their campaign apparatus, alleging 50 violations of the states Political Reform Act. The younger Murray in particular was rebuked by FPPC staffers for what they deemed a "pattern" of not filing campaign-contribution reports and failing to declare income related to the family slate-mail company. For his part, Kevin Murray dismisses the infractions as mere administrative oversights. "There was no deceit," he told Copley News Service. "It was negligence." The commission is currently considering the matter and could levy a fine as high as $104,000. The complaint was the second major filing lodged against the elder Murray now 67 years old, and his United Democratic Campaign Committee. In 1989, the commission fined Willard Murray $12,500 for failure to disclose $76,000 in late contributions to his Assembly campaign, as well as failure to report a $12,500 contribution to the campaign from the slate-mailing firm. Under the guidance of veteran political consultant Richie Ross, Archie-Hudson made Murrays character the target of her first mailer, a post card accusing Murray of voting to cut Supplemental Security Income (SSI) to the elderly while using taxpayers money to buy a sports car. Murray calls the charges unfair, clarifying that he simply voted to approve a budget deal that had been approved by the Democratic leadership. As for the car, Murray said it was simply a matter of personal taste. This type of campaign does not bode well for voter turnout in a district where recent campaigns for the Assembly have been decided by as little as 25 percent of the electorate. "When the discussion tends to be personal in a campaign, it doesnt tend to be a motivator for people to vote," observes Raphael Sonenshein, author ofPolitics in Black and White
. What does bring people out, Sonenshein says, especially in the African-American community, are endorsements from recognized leaders. On that front, Murray appears to have dominated. Representative Waters, always a pivotal endorsement, is backing him, as are Reverend Cecil Murray (no relation) at the First AME Church, a slew of other religious leaders and the California Federation of Labor. Archie-Hudson managed to wrangle the support of outgoing state Senator Diane Watson and former Mayor Tom Bradley, but with perhaps as much as $100,000 less than Murrays estimated $300,000 in the bank, her campaign will be an uphill battle. Down the ballot, the race for Murrays 47th Assembly District seat is even more combative. Samuel Joey Hill, currently Murrays chief of staff, is facing Herb Wesson, right-hand man to L.A. County Supervisor Yvonne Brathwaite Burke for the right to represent the neighborhood in Sacramento. Politicos across Los Angeles, it seems, are lining up for one or the other candidate. "Every Democrat is taking sides," says Dick Rosengarten, the publisher of the political newsletterCalpeek
. "Its an insider race between two well-connected guys." Locally, the race is so contentious, some say, people backing the opposing candidates have stopped speaking to each other. Aside from Murray, the key political influence belongs to Supervisor Brathwaite Burke, who is flexing her political muscle and reputation to get Wesson elected. "Yvonne would like to be able to go to Sacramento and have her former aides in office," comments political consultant Rick Taylor. Without much name recognition, both candidates have battled for endorsements and campaign contributions. Wesson, a longtime operative in downtown politics, appears to have the financial edge. Some estimate his current war chest to be twice that of Hill, but Hill is surprising people with his ability to raise money. Still, Wesson told theWeekly
he anticipates spending $500,000 in the race, while Hills people predict $300,000. Chief of staff to L.A. City Council Member Nate Holden before moving over to Brathwaite Burkes staff in 1992, Wesson has eyed public office for some years. The City Council was his first choice, and he began to raise money and support from local officials, organized labor and businessmen as early as 1994. When Holden chose not to retire, Wesson set his sights on Sacramento. "I do two things well," Wesson told theWeekly
. "I am one hell of a Pop Warner [football] coach, and the other thing is serving the people. I cant wait to wake up in the morning to serve the people." Again, with little disagreement over the liberal agenda, the race has become a debate over who is more experienced. With a dozen years in L.A. politics under his belt, Wesson portrays himself as the candidate better able to hammer out deals. But Joey Hill, whose political career has largely been in the state capital, contends that he is the only one in the race with the knowledge of Sacramento to hit the ground running. "I dont think Herb should be running for this seat," said Les Robeson, Hills political director. "Hes prepared to work in local government not in Sacramento." Hill, in fact, learned the ropes of state politics under the tutelage of the last two leaders of the state Senate, former Presidents Pro Tem David Roberti and Bill Lockyer. He also worked for Assemblywoman Teresa P. Hughes , who is now his mother-in-law, before joining Murrays staff in 1994. While his backing comes largely from the state capital, he has garnered the support of civil rights leader Reverend James Lawson and retiring state Senator Diane Watson. With allegiances to both Brathwaite Burke and Murray, Maxine Waters, notably, has remained neutral. Hill is hoping his connection to Kevin Murray proves pivotal. According to his staff, Hill has his name on nine of the 11 candidate slate mailers to be sent out election week. Wesson, meanwhile, is depending on organized labor to counter. His campaign office is also serving as a headquarters for the "No on 226" campaign, which he hopes to piggyback to victory on June 2. Opines Taylor: "Its a good old-fashioned, knockdown, drag-out race."
Get the ICYMI: Today's Top Stories Newsletter Our daily newsletter delivers quick clicks to keep you in the know
Catch up on the day's news and stay informed with our daily digest of the most popular news, music, food and arts stories in Los Angeles, delivered to your inbox Monday through Friday.
Recommended for You
Powered by SailThru
Upcoming Events
Los Angeles Lakers vs. New Orleans Pelicans
TicketsSun., Oct. 22, 7:30pm
CSUN Mens Soccer
TicketsWed., Oct. 25, 7:00pm
Los Angeles Lakers vs. Washington Wizards
TicketsWed., Oct. 25, 7:30pm
The Sapphire Sisters
TicketsSat., Oct. 7, 7:00pmpowered by goldstar
Sponsor Content


text:
Valentine's Day Gift Ideas
The Gift Ideas That'll Guarantee You Win Valentine's Day
The AskMen Acquire team thoroughly researches & reviews the best gear, services and staples for life.
Australia World Cup Soccer Jersey
It's officially time to jump back on the bandwagon. The Socceroos are the real deal again. After sweeping to victory in the Asian Cup, the bar has been set, and there is already talk of world domination on the cards. Whether or not this happens is irrelevant; you want to be suitably dressed should the occasion arise.
$100 at Sport Shop
Ted Baker Double Wrap Bracelet
For a man, accessories can say a lot about his style. This woven leather bracelet will look perfect for anyone with a casual, relaxed dress sense.
$79.95 at The Iconic
Herschel Novel Weekender Bag
Every man needs a good overnight bag in his arsenal. Consider it your "go bag". You'll never know when you need to go, but you will want to look the part when you do. Not to mention it's an exceptional style upgrade on existing carry-on luggage, thanks to the built in shoe compartment..
$179.95 at The Iconic
Bonds Besties Skinny Trackpant
It's time to update you gym gear. Those old gym shorts just won't do unfortunately, especially if you just signed up for the yoga class. Bonds make the best track pants. Fact. Pick up a pair of their modern-style skinny fit and you'll be cutting a whole different figure when you work out. Go for a marlble grey, the running colour of choice of the great Muhammad Ali.
$49.95 at Bonds
AskMen may receive a portion of revenue if you click a link in this article and buy a product or service. The links are independently placed by our Commerce team and do not influence editorial content. To find out more, please read our complete terms of use.


text:
Notes on Sebelius' Resignation, Politics & Medicare Money, 2nd Amendment — Physician's First Watch
Notes on Sebelius' Resignation, Politics & Medicare Money, 2nd Amendment
By Joe Elia
To commentators, Kathleen Sebelius' resignation as Secretary of Health and Human Services late last week seemed the result of administration worries about the effect the Affordable Care Act could have on 2014's mid-term elections.
The Wall Street Journal characterized the resignation as "one more attempt to dodge political responsibility" for the botched rollout. Meanwhile, the New York Times' editorial page editor blogged that the President's recitation of his administration's accomplishments "didn't even mention his own health law."
And speaking of medicine and politics, it transpired that Medicare's two biggest billers in 2012, together collecting almost $40 million, made generous political contributions to Democrats, according to a Times account. One of them, found to have overbilled Medicare by $9 million, "hired the former head of the Justice Department's Medicare fraud task force" to defend himself.
Last week, the American College of Physicians urged activism on gun control. In the Washington Post, former Associate Justice John Paul Stevens suggested this: Change the Second Amendment to read "A well regulated Militia, being necessary to the security of a free State, the right of the people to keep and bear Arms [when serving in the Militia] shall not be infringed."
Wall Street Journal editorial (Subscription required)
New York Times blog (Free)
New York Times story on contributions (Free)


text:
I love the male models, if it wasn't for them, I wouldn't enjoy it as much as I am
I love the male models, if it wasn't for them, I wouldn't enjoy it as much as I am
The average dog is a nicer person than the average person
-Andy Rooney-
I can't decide if I like the men and women models competing with each other. It seems a bit like comparing apples to oranges.
"...each affects the other, and the other affects the next, and the world is full of stories, but the stories are all one." - Mitch Albom, one helluva writer.
When you throw a rock into a pack of dogs, you know which one you hit by the one that yelps!
I have to admit I was wrong, and putting the guys in has worked better and proved more interesting than I thought it would be (based on past efforts to do a male models show).
And based on a voiceover at the end of the recap show inviting viewers to try out for the next cycle, the format's going to be around for cycle 21-- Tyra's call-out was to guys as well. So I'm starting to think a male model is definitely going to win this one, especially since 4 girls and 5 guys are moving on to Bali and the home stretch.
BTW, when I raised the question of whether "personality" mattered, I didn't mean it in the sense of a model being likeable, therefore she/he wins.
I was referring to the way they dismissed Lisa D'Amato in C5 after "the diaper incident"-- they didn't make any acknowledgment of it that week, and she wasn't even in bottom two. But she was eliminated the following week after relocating to London, despite the judges having noted at panel that she was out-performing all the others in that week's "models in a phone booth" shoot. When Tyra addressed the reason she was standing in bottom two, she cited Lisa having a personality that sometimes burned a little too brightly.
So when I wondered if "personality" still mattered post-Cover Girl responsibilities, I wasn't referring to "Jourdan: bland / Nina: cutie-pie / Renee: Miss Crankypants" personality-- I meant "Is Phil too bat-$#!+ crazy to be safe to let loose on a real, paying client with a high-dollar campaign?" personality!
Last edited by SurrnderDorothy; 09-29-2013 at 12:02 PM.
So Phil didn't come back. I love how Jourdan turns everything that happens into something about her I hope Jeremy's time apart from this lot, has given him a new perspective.
Renne is getting on my last nerves, clean your nasty dishes up .!!
The average dog is a nicer person than the average person
-Andy Rooney-
I was amazed they didn't keep Phil in for the "good reality TV" factor and give him a makeover; I'll sort of miss him (and his chest hair).
I'm very happy Jeremy was the male model chosen to return; I just hope he steps it up with his modeling now that he's back in competition, though the couple of shots they showed of his post-elimination work looked really good. (I really wish he'd still been in the week they did the "flung paint" shoot; IMO his shot was equal to Jourdan's and Renee's and was the best of the guys' shots.)
I just hope the tension between Jeremy and Jourdan doesn't take his focus off to the point where he gets eliminated again . While it's fun to see her frazzled, she's strong enough that she's less likely to get eliminated before F4; unfortunately, he's not as strong a model and has some physical limitations in his face with the sleepy-eye thing (it's cute/sexy but doesn't work with everything they throw at them, and he needs to "show a new face" once in a while).
Alexandria-- *sigh*. I really feel sorry for her, getting put back in only to be immediately cut (I actually thought it was going to happen to Jeremy). But the minute she mentioned her heart problem it was obvious she wasn't going to continue, and probably better for her that she didn't. She's beautiful and I hope she hooks up with someone and gets work after the show.
Renee's attitude is really bad, but [rant]so typical of so many people I encounter in her age group. If you confront them with something they did wrong, they refuse to even acknowledge it and try to make it about you calling them on it-- "singling them out" or "being in their face/up in their business." And why do people think, "Oh, my bad." is an appropriate response to everything they're called on? Don't they see how dismissive it is?[/rant] (For the record: in my job, I have to supervise university students 40+ hrs/wk)
I thought it would be Jeremy that came back. I'm not surprised he got the social media vote as he's typically handsome.
And I do like when he annoys Jourdan (as she needs to come down a peg) but I don't believe that he no longer likes her - I believe he has vestiges of interest.
Chris shouldn't have written what he did in the note. Describing the dish as ratchety - of course it got Renee's back up. But he was not wrong to write a note, or even point it out to her, albeit in different words. They're living with a bunch of people. Show some courtesy, wash your stuff. But Corey is all kinds of great the way he was talking it through with everyone. I really like him as a person. His photo this week not so much. It looked like he had a merkin on his head.
If you type "google" into google you can break the internet.
I thought Renene looked even more like a young Beverly Johnson..wow.! But her attitude sucks. I not a fan of Jeremy, I find him so blah-I don't see him staying around long.
I didn't care if Alexandra stayed or not, another blah model.
The average dog is a nicer person than the average person
-Andy Rooney-
So yeah, maybe Alexandra can come back again when she can't stay so long I was never that impressed with her anyway. She looks like a model, but that's it. I just realized last night that she reminds me of Alana from Face Off.
I'm not happy to see Jeremy back in the competition. I'd much prefer Phil. Clearly, he really wanted to be there. Poor guy was shaking like a leaf before the announced the results.
I'm so sick of the bad attitudes. Do they not realize that the entire show is a job interview? If they don't win, they still could have a career. Acting like a petulant child who can't get along with anyone isn't going to make someone want to hire them after the show is over.
Anti-intellectualism has been a constant thread winding its way through our political and cultural life, nurtured by the false notion that democracy means that 'my ignorance is just as good as your knowledge.' - Isaac Asimov
I was thinking of the immortal words of Socrates, who said, "... I drank what?"
I would have rather had Phil return too.
I like Cory and I agree with his assessment.
Apparently this is not shown here in St. Louis. The CW site is tripping out. Where can I catch the episodes online?
"My life gets less like chess and more like whack-a-mole every day."
<-- "I'm Hexy and I know it!"


text:
Weather may have triggered the inadvertent activation of several outdoor warning sirens today in the region, said Lake County Emergency Management Agency Director Larry Greene.
"At 12:32 p.m. this afternoon, several outdoor warning sirens located in Lake, Geauga and Ashtabula counties inadvertently sounded," Greene said. "It's believed that the activation may have been attributed to heavy thunderstorms and lightning that moved through the area at the time."
Technicians are inspecting the siren system in wake of the miscue.
"In the meantime, the Lake County Emergency Management Agency is advising residents there is no cause for concern," Greene said.


text:
Washington State Department of Ecology - June 19, 2013
BELLINGHAM - The Washington Department of Ecology (Ecology) has approved the city of Burlington's updated shoreline master program.
The city's shoreline program will result in significant improvements in the protection, use, development and restoration of roughly three miles of shoreline and the water quality of the Skagit River and Gages Slough.
The new master program combines local plans for future shoreline development and preservation with new shoreline development ordinances and related permitting requirements.
"Burlington has developed a shoreline master program that will help the statewide effort to protect the economic and environmental health of our waterways. We appreciate the city's work to involve many interested parties in this update. Together, we are protecting our treasured shoreline resources now and for future generations," said Erik Stockdale, Ecology's acting regional shorelines program supervisor.
Cities and counties statewide are in the process of, or soon will be, updating or developing their master programs under the state's 1972 voter-approved Shoreline Management Act.
Shoreline master programs are the cornerstone of the act. The law requires cities and counties with regulated shorelines to develop and periodically update their locally tailored programs to help minimize environmental damage to shoreline areas, reserve appropriate areas for water-oriented uses, and protect the public's right to public lands and waters.
The city brought diverse local interests to the table to work collaboratively. Burlington collaborated over three years with waterfront property owners, environmental interests, local governments, tribes and state agencies. The shoreline master program process began with a thorough inventory of existing land-use patterns and environmental conditions and was completed by city staff.
Burlington's shoreline master program:
Media Contacts:
Larry Altose, Ecology media relations, 425-649-7009, email@example.com
Bob Fritzen, Ecology shoreline planner, 360-715-5207, firstname.lastname@example.com
Margaret Fleek, Planning Director, City of Burlington, 360-755-9717, firstname.lastname@example.com
For more information:
Burlington's master program:
Shoreline master programs (www.ecy.wa.gov/programs/sea/shorelines/smp/index.html)
Our Living Shorelines web portal (www.ecy.wa.gov/livingshorelines/index.html)
Ecology's social media (www.ecy.wa.gov/about/newmedia.html)
Copyright © Washington State Department of Ecology. See http://www.ecy.wa.gov/copyright.htm


text:
The depth and talent on the Anaheim Ducks' blue line took a hit Wednesday when the team announced that defenseman Cam Fowler likely will miss the rest of the regular season with a sprained left MCL suffered last week.
The expected recovery time is 3 to 5 weeks.
Fowler's injury comes at a bad time because the San Jose Sharks have taken advantage of the Ducks' recent struggles to tie them atop the Pacific Division standings with 97 points entering Wednesday's games.
Fowler, 22, has tallied 36 points in 67 games this season. His powerful shot, play-making skill and impressive skating ability will be missed on the Ducks' power play, which already is struggling with just a 16 percent success rate.
Luckily for the Ducks, they got veteran blueliner Stephane Robidas back in the lineup Tuesday night following his four-month recovery from a broken leg. He was acquired from the Dallas Stars just before the NHL trade deadline earlier this month.
Powered by WordPress.com VIP


text:
> PM: I wonder if we can get this functionality in the backend's parser - > ie, for the API interfaces, they can set a variable on startup that > disables begin, commit and rollback, then when they need to use them, it > can then either temporarily clear the variable, or use a prefix that > forces the statement to work? > > PM: enableSQLTransactions can then act immediately above this > functionality. That's what I was hoping for. > 2. prepare -- should return false if the transaction is read-only, true > if it will commit, throw an exception if it will rollback Works fine now that I've added a check for *ABORT STATUS*. > 3. isCriticalError -- should tell me if a critical error occured in the > connection and the connection is no longer useable > > How do I detect no. 3? Is there are certain range of error codes, should > I just look at certain PSQLExceptions as being critial (e.g. all I/O > related errors)? > > PM: Don't rely on the text returned from PSQLException to be in English. > We are pretty unique in that the driver will return an error message in > the language defined by the locale of the client (also depends on if we > have translated the errors into that language). What I could to is add a > method to PSQLException that returns the original id of the Exception, > and another to return the arguments supplied. That may make your code > more portable. I'm not looking into the messages, I know their language dependent. I even added two or three new error messages, but only in English. I'm looking for either specific error codes, range of error codes, or some class extending PSQLException that will just indicate that this connection is no longer useful. For example, if an I/O error occurs, there's no ReadyForQuery reply, there's garbled response, etc. arkin > > Peter > > -- > Peter Mount > Enterprise Support > Maidstone Borough Council > Any views stated are my own, and not those of Maidstone Borough Council. > > ************ -- ____________________________________________________________ Assaf Arkin arkin(at)exoffice(dot)com CTO http://www.exoffice.com Exoffice, The ExoLab Company tel: (650) 259-9796
Next: From: Jan Wieck Date: 1999-12-09 19:43:17 Subject: Weired FK problem Previous: From: Don Baccus Date: 1999-12-09 16:00:50 Subject: check contraints incorrectly reject "null"
Next: From: Adolfo Diaz Date: 1999-12-09 20:14:57 Subject: Apache+PostgreSQL+PHP3 Previous: From: Assaf Arkin Date: 1999-12-09 18:14:16 Subject: Re: [INTERFACES] Transaction support in 6.5.3/JDBC