text:
General News of Tuesday, 3 July 2012
Source: GNA
Nana Addo Dankwa Akufo-Addo, Flagbearer of the New Patriotic Party (NPP) in Election 2012, on Monday said that the previous NPP administration of former President John Agyekum Kufuor was the best Government Ghana ever had.
He said the previous NPP Government created jobs for the youth of the country through schemes such as the National Youth Employment Programme and also implemented programmes such as the National Health Insurance Scheme and Free Health Care for pregnant women.
Nana Addo was addressing supporters of the NPP at the campaign launch of Lawyer Sara Adjoa Safo, the party's Parliamentary Aspirant for Dome/Kwabenya in the Greater Accra Region.
He said the NPP was the only party which could improve the standards of living of Ghanaians and called on the people to vote massively for the party on December 7 to save Ghana from the payment of judgment debts instead of paying better salary to teachers.
Nana Addo said his policy for free education up to the secondary level and the improvement of the condition of teachers was achievable.
He said "former president Kufuor's government was building a six-classroom block at 70,000 Ghana Cedis, but now it is 250,000 Ghana Cedis and a bag of cement is being bought for 25 Ghana Cedis. Where are we going?"
Former President Kufuor said jobs which were created under his Government had all collapsed under the National Democratic Congress (NDC) Government led by President John Evans Atta Mills and asked the youth to vote for Nana Akufo-Addo for jobs and development.
He said the first year of his government was difficult, but hard decisions were taken by his Cabinet to manage the 'broke economy' which was left behind by the NDC.
Former President Kufuor said his administration which placed the country to where it was now would not have spent more than 420 million dollars on the payment of judgment debts.
Professor Mike Oquaye, Second Deputy Speaker of Parliament and Member of Parliament (MP) for Dome/Kwabenya, asked the constituents to remember the good work he has done and expressed hope that they would give Lawyer Safo the node to continue from where he would leave.
He said the NPP was a big political party that aimed at improving the lives of Ghanaians and also to develop the human resource and capacity of the country to meet international standards.
Prof. Oquaye also donated 4,000 Ghana Cedis to support the campaign of Lawyer Safo and called on the electorate to vote for her and the NPP to move Ghana forward.
Lawyer Safo said, the constituency has experienced a lot of infrastructural development under Prof. Oquaye and appealed to the electorate to vote for her to continue the good work of the MP.
She said that the NPP policy on free education up to the secondary level was the first ever in Ghana's history.
Lawyer Safo said "the constituency is the World Bank of the NPP in the Greater Accra Region."**


text:
Vehicles sorted from highest to lowest price
Used Sedans Under $13000
Inventory Page 23 of 227
5 Photos
Condition like new clean title
5 Photos
MD inspected, leather interior, sunroof, 6 CD player, navigation system, powered everything....
- 1-Owner Vehicle
6 Photos
Nissan Altima S in Houton TX for less than $7K. Loaded with an economy 4 cylinders engine and...
4 Photos
Black w/V-Tex Leatherette Seating Surfaces and Power moonroof. Turbo Charged! NO ACCIDENTS,...
- Finance Available
4 Photos
Ford FEVER! Drive this home today! If you want an amazing deal on an amazing car that will not...
- Finance Available
6 Photos
This cheap Mitsubishi Galant could be yours for only $174 per month. This vehicle is great for...
- Finance Available
6 Photos
For more information of this Honda Civic for sale in Raleigh, North Carolina, for under $7000...
- Finance Available
8 Photos
A great car at a great price that won't last long and you must see to appreciate it. This...
- Finance Available
- Certified Pre-Owned
6 Photos
Good running car, sold AS-IS, the price is negotiable, windshield has a crack, comes...
12 Photos
Selling our 2000 Toyota Camry XLE V6 sedan under $7000 dollar for an affordable low price....

subset: commoncrawl


text:
How to Clean Hood Filters
Recipe by gailanng
This method is nothing short of a miracle to clean kitchen hood filters. Non-toxic and cheap, cheap, cheap! The only problem you should have is finding the right vessel. I used a roasting pan, but maybe using a disposable aluminum pan would work. Add the soda at the beginning to the cool water so it doesn't fizz and overflow. As embarrassing as it may be for me to show how bad mine were, note the differences. The foremost filter in the picture is one that's been cleaned by this method.
Top Review by lazyme
This is awesome! I knew that my filters were dirty, but had no idea until I tried this. lol. They look great and I don't get sticky fingers touching them anymore. Thanks gailanng for sharing this wonderful keeper. Made for PRMR tag.
See Discussion:17 Reviews
Ingredients Nutrition
- 1⁄2 cup baking soda
- water
Directions See How It's Made
- Fill a large heat-resistant vessle, like a pot or flat rimmed baking sheet with baking soda. Add enough water to fill without spilling over. Place in the hood filter and turn up the heat to a slow boil.
- This takes about 5-10 minutes. Since I placed mine flat in a rimmed baking sheet, I was able to assist the removal of build up with a toothbrush. I, also, with tongs flipped the filter over. The water will foam, raising the residue to the top. Rinse thoroughly.
- Repeat with remaining filters.


text:
Magic spring break cruise 3-11-2012: Carnival Magic Cruise Review by rgrountree
Overall Member Rating
Magic spring break cruise 3-11-2012
Destination: Eastern Caribbean
Embarkation: Galveston
Embarkation - no issues, we got on the boat in around 30 minutes very painless. I would recommend for those driving in from Houston to not use Harbor Side drive to approach the ship. There was a long line of cars waiting to turn into the terminal. Instead stay on 45 until at least 21st street (take left) then turn left on Harborside. No waiting to turn into the terminal from this direction.
Ship info - We really did enjoy the ship. There are lots of option and things to do throughout and lots of public areas between the Promenade (Deck 5) and Lido (Deck 10). There were over 4500 people on board for this spring break cruise. I must say I was concerned about lines and long waits. I can say that there were never really any issues for us around waits or excessive crowding. Sea days More were certainly more busy as would be expected but not unmanageable. We did arrive early for shows as these do fill up early in the theater and spotlight lounge area. Chair hogs were out in force and many chairs were unoccupied by people - only towels.
Stateroom - we had a balcony (8A - 6215) and the cabin did have very good storage options for the 4 of us. No issues with the cabin at all.
Dining: We found the food to be great and enjoyed the food in the main dining room, lido buffet, as well the oceanside barbecue. Main dining service for dinner was fantastic and we enjoyed the service as well as the singing - pretty talented.
Entertainment - we most enjoyed the Juggling/comedy act - we all laughed pretty hard on a simple step ladder joke. Spotlight comedy shows were good too as was the final Legends show with passengers participating.
Key West - we spent half the day onboard the ship enjoying all the amenities all to ourselves - slides, ropes course, hot tubs, lido buffet. We had a great time and I highly recommend staying on board for one port. We did enjoy a few hours on Key West at the aquarium and walking through the streets.
Freeport - We booked with Paradise Cove to go snorkeling at Deadman's reef. Beautiful location and the snorkeling was good - we saw 4 eagle rays, a barracuda, cuddlefish. It is a long swim to get out to the reef but we made it out there and back (tired). It seemed they were overbooked this day. Many customers were waiting on equipment that was not available and it seemed a bit disorganized. We still had fun though. Bring your own equipment if you have it.
Nassau - We did the Dolphin Encounter at Blue Lagoon. The dolphin encounter was great and informative, we all enjoyed the experience. This is a great facility and there are other options on site to play with water toys and a beach, so I recommend going early so you can enjoy all the facility has to offer.
Disembarkation - We did the Self Assist disembarkation which meant we carried our own luggage off the boat. I recommend you do this as you get off the ship first with luggage in hand. Did not take us more than 30 minutes to get out.
Overall - We had a great spring break cruise and really did enjoy ourselves. We would do it again without hesitation. Less
Published 03/20/12
Cabin review: 8A6215 Balcony
We had a balcony cabin 8A on deck six - cabin 6215. The cabin was good for us. We were initially concerned about the proximity to deck 5 but this cabin is well forward of any areas that would be noisy. No issues at all with this cabin and would recommend cabins in the forward area of deck 6.Read All Balcony (8A) Reviews >>
Read Cruise Critic's Carnival Magic Review >>
Great Ship and Crew
They thought of everything
First Time Cruising Family had...
Amber Cove was beautiful!
Cruising with Family
Carnival Magic Very Disappoint...
First Time Cruising Family had...
Not the best Carnival trip
Sponsored Links


text:
DUBAI, UNITED ARAB EMIRATES – The U.S. on Wednesday accused Iran of launching a "highly provocative" rocket test last week near its warships and commercial traffic passing through the Strait of Hormuz, exposing how tensions between the two countries could escalate even after a landmark nuclear deal.
The strategic Persian Gulf waterway, which sees nearly a third of all oil traded by sea pass through it, has been the scene of past confrontations between America and Iran, including a one-day naval battle in 1988.
But Saturday's incident brought no immediate response from Iranian officials or media, while French authorities downplayed its danger.
Military vessels taking part in the war against the Islamic State group in Iraq and Syria also pass through the narrow waterway between Iran and Oman. On Saturday, the aircraft carrier USS Harry S. Truman,destroyer USS Bulkeley and a French frigate, the FS Provence, were passing through it, said Cmdr. Kyle Raines, a U.S. Central Command spokesman.
As they passed, Iranian Revolutionary Guard vessels, hailing other ships in the strait over maritime radio, announced they'd be carrying out a live-fire exercise, Raines said in a statement. After 23 minutes, the Iranian boats fired "several unguided rockets" about 1,370 meters (1,500 yards) from the warships and commercial traffic, he said.
While the rockets weren't fired in the direction of any ships, Raines said Iran's "actions were highly provocative."
"Firing weapons so close to passing coalition ships and commercial traffic within an internationally recognized maritime traffic lane is unsafe, unprofessional and inconsistent with international maritime law," he said.
A French military official, speaking to The Associated Press on condition of anonymity as he was not authorized to be publicly named, confirmed the rocket fire took place Saturday. However, the official said the French military did not consider it to be a threatening event as the rocket fire clearly wasn't directed toward the Western fleet.
The French frigate is now escorting the French aircraft carrier Charles de Gaulle, which is launching airstrikes against the Islamic State group, the official said.
NBC News first reported news of the Iranian rocket fire.
Sen. John McCain, chairman of the Senate Armed Services Committee, responded to Saturday's incident with renewed criticism of the nuclear deal with Iran.
"A rush to sanctions relief threatens to embolden an increasingly aggressive Iranian regime that has no intention of normalizing relations with the West or of retreating from a malign policy intended to destabilize the Middle East," McCain said in a statement released Wednesday. "We need to ensure that U.S. forces are postured to respond to Iranian aggression and finally adopt a comprehensive strategy to counter Iran's malign influence in the Middle East."
The Wall Street Journal reported Wednesday that the U.S. Treasury Department was preparing sanctions against several individuals and companies in Iran, Hong Kong and the United Arab Emirates related to Iran's ballistic missile program. Treasury and the White House declined comment on the Journal report, which was attributed to anonymous U.S. officials.
The Strait of Hormuz is only about 33 km (21 miles) wide at its narrowest point. Ships traversing the choke-point have even less room to maneuver. The shipping lane in either direction is only 2 miles (3.22 km) wide, with a 2-mile (3.22-km) buffer zone between them.
The U.S. Navy's 5th Fleet is based in nearby Bahrain, on the southern coast of the Gulf. It conducts anti-piracy patrols in the greater Gulf and serves as a regional counterbalance to Iran.
U.S. and Iranian forces clashed in the Strait of Hormuz in the 1980s, during the Iran-Iraq war. On April 18, 1988, the U.S. attacked two Iranian oil rigs and sank or damaged six Iranian vessels, including two naval frigates, in Operation Praying Mantis. That came after the near-sinking of the missile frigate USS Samuel B. Roberts by an Iranian mine.
A few months later, in July 1988, the USS Vincennes in the strait mistook an Iran Air flight heading to Dubai for an attacking fighter jet, shooting down the plane and killing all 290 passengers and crew onboard. The shoot-down of the jet came shortly after the U.S. vessel reported coming under fire from Iranian speedboats.
Tensions have persisted in the strait even into this year. Iran sank a replica of a U.S. aircraft carrier in February near the strait and it earlier tested "suicide drones" it said could crash into naval vessels.
Iran seized a Marshall Islands-flagged cargo ship and later released it in May after its forces had earlier surrounded a U.S.-flagged cargo ship transiting the strait. That caused the 5th Fleet to escort commercial ships traveling in the Gulf for a short time.
The Wall Street Journal reported Wednesday that the U.S. Treasury Department was preparing sanctions against several individuals and companies in Iran, Hong Kong and the United Arab Emirates related to Iran's ballistic missile program. Treasury and the White House declined to comment on the Journal report, which was attributed to anonymous U.S. officials.
Iran and world powers led by the U.S. agreed to a landmark nuclear deal earlier this year to limit Tehran's enrichment of uranium in exchange for lifting economic sanctions. Iran has always denied seeking nuclear arms.
The deal reached with moderate President Hassan Rouhani's administration has been panned by Iranian hard-liners, and in the months since, Iran has conducted missile tests criticized by the U.S., as well as aired footage on state television of an underground missile base.
Saturday's rocket fire should be seen as part of a pattern by Iran since its naval loss in 1988, said Eugene Gholz, an associate professor at the University of Texas who is an expert on the use of military power in the Strait of Hormuz. Iran wants to portray itself as the region's major power, but doesn't want to directly battle U.S. naval forces again, he said.
"Theater is a good word for it," Gholz said. "You build a set, you carry out activity on the set, you send actors — in this case (Iranian Revolutionary Guard) special forces — and you hope people are watching and really paying the price of admission."


text:
Hard Work, Innovation, Risk Taking, Sacrifice Are What Built New York's Economy And Will Make It Work Again, Not "Success Taxss"
Legislative column from Assembly Minority Leader Brian M. Kolb (R,I,C-Canandaigua)
October 14, 2011
Here is one thing that former President Bill Clinton and I have in common: We both clearly realize that now is NOT the time to be raising taxes. In fact, here is what President Clinton recently said about proposed federal tax hikes: "Should you raise taxes on anybody right today – rich or poor or middle class? No, because there's no growth in the economy." President Clinton got this one 100 percent correct. In such a tough economy and with over 700,000 New Yorkers out of work, increasing taxes will do even more harm and send the wrong message to private sector job creators. Unfortunately, some liberal politicians in Albany disagree and actually want to bring back New York's "Success Tax" surcharge. This is a bad idea. Never in recorded history has a civilization ever taxed itself to prosperity. Even though we were able to defeat an attempted extension of the Success Tax in the 2011-12 State Budget and stop its passage as stand-alone legislation, there has been renewed talk of reinstituting the Success Tax in 2012. You may recall that the Success Tax surcharge was originally part of $10 billion in new taxes and fees that were enacted as part of the 2009-10 State Budget. I led the fight against that misguided spending plan and now want to make certain the Success Tax is history, ancient history. ALBANY HAS A SPENDING PROBLEM, NOT A REVENUE PROBLEM Supporters of the Success Tax will argue, mistakenly, that state government faces a revenue problem and needs "just a little bit more" of your hard-earned taxpayer dollars to operate. Baloney! The total 2011-12 enacted State Budget (all funds) was $131.2 billion. For a frame of reference, $131.2 billion is roughly enough money to buy eight state-of-the-art aircraft carriers – or 33 General Motors buildings. Does it sound like New York State is cash strapped to you? The truth is that Albany has more than enough money to meet state government's basic obligations and still fund the essential programs New Yorkers count on. Albany does not have a revenue problem – it has a spending problem. TRUTH ABOUT TAXES: WHO REALLY PAYS, WHY SUCCESS TAXES FAIL As the only Legislative Leader in state government with a business background and 25 years experience in the private sector, I know what built New York's economy: hard work, innovation, risk taking and sacrifice. These very same things will get our economy moving again and help put unemployed New Yorkers back to work. Accordingly, here are some basic facts about state tax policy that Success Tax supporters are either unaware of, or simply do not want you to know. Let's call it "Taxes 101" and class is now in session:
- According to the State Department of Taxation and Finance, those with incomes exceeding $200,000 account for 5.5 percent of taxpayers in New York State, yet they pay 54 percent of total Personal Income Tax receipts;
- Less than 1 percent (.6 percent) of the top income earners pay over 32 percent of the total Personal Income Tax receipts;
- Those with incomes under $50,000 account for over half off all taxpayers in New York State (51.7 percent), yet pay a mere 8.4 percent of the total Personal Income Tax receipts;
- When Oregon enacted its Success Tax, the state collected nearly one-third less revenue than projected; and
- When Maryland enacted its Success Tax, it saw roughly one-third of its millionaire households disappear from the tax rolls after its state tax rates increased, as noted in the Wall Street Journal.


text: Icon Item Name Qty Drop Rate Type Jaggi Scale+ ジャギィの上鱗 1 55% Body Carve Avian Finebone 上質な鳥竜骨 1 22% Body Carve Bird Wyvern Fang 鳥竜種の牙 1 15% Body Carve Jaggi Hide ジャギィの皮 1 8% Body Carve Retrieved from "http://monsterhunter.wikia.com/wiki/Jaggia_Carves/MH4-High-rank?oldid=677434" Ad blocker interference detected! Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers Wikia is not accessible if you've made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.


text:
Bollywood actor-producer Anil Kapoor, who is making his debut on the small screen with a fictional show, says he believes in taking risks. The 53-year-old actor will be seen in his television production '24', a suspense drama show based on the American series of the same name.
"I have tried to do out of the box things which are risky, which have a possibility of failing miserably. But I enjoy it when people make fun of me... as it helps me work even harder," Kapoor said in an interview here.
"TV has got the biggest reach. I don't know how many years it is going to last. Now even internet is catching up. We have to pull up our socks as everything is going to be watched on internet," he said.
Even megastar Amitabh Bachchan is coming on TV with a fiction show and Kapoor is quite happy about it. "His coming on a show makes my stand of being in this show ('24') even stronger," Kapoor said. It was the format of the show that drew Kapoor to make it in India. "When I was in US doing '24' over there, I had made up my mind to bring this iconic show to India. I felt this show is relevant in our country today. We wrote an email and negotiated with the concerned officials. I am glad it happened," Kapoor said.
The actor is thankful to Colors channel for partnering with him in taking this programme to the masses. For the Indian version of the show, Anil said that the challenge was to get the same kind of aesthetics, scale and performance.
"Those shows are made at a cost of four to six billion dollar per episode. We are not going to spend that much amount of money. But we had to raise the bar and make the show as effective as the original with lesser time and money. The entire team has put in a lot of passion and hard work. We have put our best foot forward which we hope will be loved by the people," he said.


text:
The present study was undertaken to determine whether the severity of renal failure or hypertension in homozygous cyclooxygenase (COX)-2-deficient (COX-2−/−) mice affected by genetic background or gender. COX-2 deletion was introduced into three congenic genetic backgrounds, 129/Sv (129/COX-2−/−), C57/BL6 (C57/COX-2−/−), and BALB/c (BALB/COX-2−/−), by backcrossing the original mixed-background knockout mice with the respective inbred strains for 9 or 10 generations. Evaluation of the severity of hypertension and renal failure was performed in knockout and wild-type mice at the age of 2.5–3.5 mo. Blood pressure measured by tail-cuff plethysmography was significantly elevated in the male 129/COX-2−/− mice (165.8 ± 9.2 vs. 116 ± 5.1 mmHg, P < 0.05), and to a much lesser extent in the female 129/COX-2−/− mice (127.4 ± 3.3 vs. 102.4 ± 3.3), whereas it was unchanged in the C57- or BALB/COX-2−/− mice regardless of gender. Urinary excretion of albumin, determined by EIA, was remarkably increased in the 129/COX-2−/− (16.4 ± 4.1 vs. 0.16 ± 0.043 mg albumin/mg creatinine, P < 0.001), and to a lesser extent in the male C57/COX-2−/− mice (0.595 ± 0.416 vs. 0.068 ± 0.019). Albumin excretion was not elevated in the male BALB/COX-2−/− or in female COX-2−/− mice on any of the three genetic backgrounds. Histological analysis showed abundant protein casts, dilated tubules, and infiltration of inflammatory cells in the male 129/COX-2−/− mice, but not in COX-2−/− mice in other strains or gender. However, the presence of small glomeruli in the nephrogenic zone was observed in all strains of COX-2 knockout mice, regardless of genetic background and gender. Therefore, we conclude that the severity of hypertension and renal failure in COX-2-deficient mice is influenced by genetic background and gender, whereas the incomplete maturation of outer cortical nephrons appears to be independent of genetic background effects.
cyclooxygenase, also called PGH synthase, is a rate-limiting enzyme catalyzing the metabolism of arachidonic acid to PGH2, the common precursor for the synthesis of bioactive prostaglandins (PGs). COX exists in two distinct isoforms, the constitutive COX-1 and the inducible isoform COX-2 (37). COX-1 is expressed in a wide variety of tissues, and its expression level doesn't appear to undergo robust changes under most experimental conditions. COX-1 mediates housekeeping functions such as platelet aggregation and cytoprotection in the gastrointestinal tract. Some evidence suggests that COX-1-derived PGs may exert vasoconstrictive and sodium-retaining effects (1, 31), but its exact function in the kidney has largely remained elusive. In contrast, COX-2 is much more restricted in its expression and its abundance is highly inducible by growth factors and cytokines as well as physiological stimuli. In the kidney, COX-2 is constitutively expressed in the macula densa and thick ascending limb cells as well as in renal medullary cells in which the expression undergoes dynamic changes under changing states of sodium and water balance (4, 12, 39). COX-2 has been shown to influence renin secretion (6, 40) and renal hemodynamics (21, 22, 29, 32, 33). As in many other areas of research, gene knockout technology has provided powerful tools for studying the functional roles of the two COX isoforms. COX-1 knockout (KO) mice have a virtually normal phenotype, and there are no obvious renal structural abnormalities (19). In contrast, COX-2 KO mice show marked renal pathology, including hypoplasia of the nephrogenic zone and tubular atrophy, starting at postnatal periods (8, 27).
Although the kidney abnormalities in COX-2 KO mice were observed consistently in a number of studies, the severity of the renal dysfunction appears to be variable. COX-2−/− mice, as generated by Dinchuk at al. (8), develop severe renal abnormalities, including an overabundance of immature small glomeruli and multiple foci of dystrophic tubules in the subcapsular zone at postnatal day 2 (PND2), and the average life span of these mice has been reported to be only ∼3 mo. COX-2−/− mice subsequently developed by Morham et al. (27) showed a milder renal pathology, with 75% of the mice having a life span of longer than 6 mo. Since the gene pool of the two COX-2−/− strains represents a mixture of C57/BL6 and 129/Sv DNA, it seems possible that differences in the genetic background may account for the phenotypic variations. Despite the reduced renal function, blood pressure in these mice is usually normal and gender differences in the progression of the disease have not been reported.
The present study was undertaken to determine whether the severity of renal failure or hypertension in COX-2 KO mice is affected by genetic background or gender. COX-2 deletion was introduced into 129/Sv, C57/BL6, and Balb/C congenic genetic backgrounds by backcrossing the original KO mice with the respective inbred strains for 9 or 10 generations. Remarkable differences in the severity of renal failure and hypertension were observed among different strains and between genders, with the most severe phenotype being found in male COX-2 KO mice on 129 genetic background.
Establishment of COX-2 congenic lines.
COX-2−/− mice on a mixed 129/C57 background were originally generated by Dinchuk et al. (8), and the breeder pairs were obtained from Jackson Laboratories. Inbred 129, C57, and BALB mice were purchased from the same vendor. Using the conventional backcross breeding strategy, congenic COX-2 KO strains were generated (3, 16) by crossing male heterozygous COX-2−/− mice with females of each of the inbred recipient strains. After genotyping, male heterozygous offspring were chosen as breeders and again crossed with females of the inbred strains. This breeding strategy was repeated over 3 yr for 9 generations of backcrossing in the case of BALB and for 10 generations in the cases of C57 and 129/Sv. Congenic homozygous mice were obtained by brother/sister mating of heterozygous animals of the N9 and N10 generation, respectively.
Genomic DNA was isolated from a short piece of tail taken at the time of weaning. Genotyping was determined by PCR with COX-2 gene-specific primers positioned in the targeted region and with Neor-specific primers. The sequence of the oligonucleotide primers and their location in the public sequence are as follows: COX-2 sense 5′-GCAGCCAGTTGTCAAACTGC-3′ (bp 961–980) and COX-2 antisense 5′-CTCGGAAGAGCATCGCAGAGG-3′ (bp 1081–1112) (10); and Neor sense 5′-CTTGGGTGGAGAGGCTATTC-3′ (bp 191–210) and Neor antisense 5′-AGGTGAGATGACAGGAGATC-3′ (bp 451–470) (2). For the studies of gender difference in the postnatal period, the gender of the pups was determined by PCR detection of sex-related polymorphism of the SMCX gene. The sequence of the primers is as follows: SMCX sense 5′-CCGCTGCCAAATTCTTGG-3′ and SMCX antisense 5′-TGAAGCTTTTGGCTTTGAG-3′ (provided by Jackson Laboratories). Amplification was carried out for 30 cycles of 94°C for 40 s, 58°C for 40 s, and 72°C for 40 s, followed by a final extension at 72°C for 8 min.
Blood pressure measurement.
Systolic blood pressure was measured by a tail-cuff method using a Visitech BP2000 Blood Pressure Analysis System (Apex, NC) (18). All animals were habituated to the blood pressure measurement device for 7 days. They all underwent 2 cycles of 20 measurements reordered per day for a minimum of 3 days.
Morphological studies.
Kidneys were hemisectioned and fixed by direct immersion in 3% paraformaldehyde for 16 h. After being embedding in paraffin, 5-μm sections were prepared and stained with hematoxylin and eosin. Renal pathology scores were generated by two observers who were blind as to the identity of the specimen. The following parameters were scored on a 1–5 scale (the higher the number, the more severe the injury): interstitial changes (infiltration of inflammatory cells or deposition of matrix), dilation of tubules, and tubular necrosis (sloughing of epithelial cells). A composite injury score was generated by averaging the above parameters.
Albumin enzyme immunoassay.
Mice were placed in metabolic cages for 24-h urine collection. The urine samples were centrifuged at 10,000 rpm for 5 min, and the supernatant was subjected to albumin enzyme immunoassay at 1:13 dilution. The assay was performed using an Albuwell kit according the manufacturer's instruction (Exocell, Philadelphia, PA).
Plasma chemistries.
Plasma blood urea nitrogen (BUN) was determined by the SYNCHRON LX system (LX-20, Beckman Coulter), which detects the changes in the solution conductivity after enzymatic conversion of a nonionic species (urea) to an ionic species (NH4+). Plasma creatinine was determined by the Jaffe method.
Statistical analysis.
Values shown represent means ± SE. Statistical analysis was performed by ANOVA and Bonferroni's tests with a P value of <0.05 being considered statistically significant.
Systolic blood pressure.
Wild-type and homozygous COX-2 mice on various genetic backgrounds in the 2.5- to 3.5-mo age range were subjected to systolic blood pressure measurement using a tail-cuff computerized system. As shown in Fig. 1, blood pressure was significantly elevated in the male 129/COX-2−/− (165.8 ± 9.2 vs. 116 ± 5.1 mmHg, P < 0.05) and to a much lesser extent in the female 129/COX-2−/− (127.4 ± 3.3 vs. 102.4 ± 3.3) mice, but C57/COX-2−/− or BALB/COX-2−/− mice regardless of gender were normotensive.
Adult mice were placed in metabolic cages, and 24-h urine was collected for determination of urinary albumin and creatinine. To eliminate the influence of urine evaporation, the ratio of urinary albumin vs. creatinine is presented. Urinary excretion of albumin, determined by EIA, was significantly increased in the male 129/COX-2−/− mice (16.4 ± 4.1 vs. 0.16 ± 0.043 mg albumin/mg creatinine, P < 0.001), and to a lesser extent in the male C57/COX-2−/− mice (0.595 ± 0.416 vs. 0.068 ± 0.019), whereas there was no albuminuria in the male BALB/COX-2−/− or in female COX-2−/− mice on any of the three genetic backgrounds (Fig. 2).
Renal morphological analysis.
Examples of renal histological sections from male and female adult mice are shown in Figs. 3 and 4. Small glomeruli in the superficial cortex throughout adulthood, a hallmark of the postnatal abnormalities in kidney maturation of COX-2 KO mice, were observed in all congenic COX-2−/− mice, regardless of strain and gender. However, the severity of kidney injury varied markedly between different strains and genders, with the most severe injury occurring in the male 129/COX-2−/− mice. As shown in Fig. 3, renal histology of male 129/COX-2−/− mice exhibited large amounts of protein casts, dilation of tubules, and infiltration of inflammatory cells. In contrast, these pathological changes were much milder in the female counterparts of the same strain or in the BALB/COX-2−/− or C57/COX-2−/− strain. Furthermore, an injury score system was used for semiquantitative analysis of the major pathological parameters as described in previous studies (20). The score was based on a 1–5 scale, with higher numbers indicating more severe injury. As shown in Fig. 5, the highest injury score was found in the male 129/COX-2−/− mice.
Plasma chemistry.
Plasma BUN was significantly increased in all congenic COX-2−/− mice regardless of genetic background and gender (Fig. 6). The greatest increase was found in the male 129/COX-2−/− mice, but the plasma BUN variations in the different congenic strains and genders were not as striking as the histological changes or albuminuria. Surprisingly, plasma creatinine, determined by the Jaffe method, was not significantly increased in any strains of the congenic KO mice despite the clear evidence of renal failure in these mice (data not shown). Plasma Na, K, and Cl concentrations were not significantly altered in the three strains of congenic KO mice when the animals were kept on a normal-sodium diet (data not shown).
Examination of gender difference in young 129 mice.
Considering the remarkable gender difference in 129 strain adults, we performed further studies to determine the time frame for the occurrence of this phenomenon. Specifically, we attempted to compare the renal phenotype between the genders at various postnatal periods including PND7 and 14. Because visible identification of the gender in the pups was difficult, we performed PCR analysis of the SMCX gene, which shows a sex-related polymorphism (Fig. 7). To validate the method, PCR of the SMCX gene was performed on tail DNA of four male and four female mice at weaning. The PCR products were detected as a single band in females while as two bands in males, thus permitting a clear gender distinction. As shown in Fig. 8, the abnormality of postnatal kidney development, as evidenced by the presence of increased numbers of small glomeruli in the superficial cortex, was detected in the 129/COX-2−/− mice at PND7 and was more pronounced at PND14. However, no gender differences in renal histology or in plasma BUN (Fig. 9) were detected in the young 129/COX-2−/− mice.
COX-2 KO mice developed by two independent groups of investigators develop a comparable renal phenotype starting at an early postnatal period (8, 27). The most striking abnormality consists of a persistence of hypotrophic tubules in the nephrogenic zone with a large number of immature glomeruli and dystrophic tubules. A similar renal phenotype can also be produced by pharmacological blockade of COX-2 (17). These observations suggest a critical role of COX-2 in postnatal kidney development. However, the severity of the renal pathology in COX-2−/− mice varies considerably, suggesting the existence of modifying factors. To investigate the possible influence of the genetic background on the renal phenotype induced by COX-2 deficiency, we developed various congenic strains of COX-2-deficient mice using the backcross breeding strategy. Three congenic strains in a C57/BL6, 129/Sv, or BALB/c background were generated by crossing the original COX-2−/− mice into the respective inbred strains for 9 or 10 generations. The entire breeding procedure took ∼3–4 yr, a typical generation time with the conventional backcross protocol (3, 16). To our knowledge, this is the first report on the generation of congenic strains of COX-2−/− mice. These models provide a novel tool for the study of genetic factors that may affect the development of chronic renal disease.
A persistent presence of immature glomeruli in the superficial cortex was observed in COX-2−/− mice in all three congenic strains as previously described in the mixed background C57/129 strain. Regardless of genetic background or gender, the impairment of nephrogenesis in COX-2-deficient mice appears to eventually progress to chronic renal failure, as evidenced by the rise in plasma BUN. These findings demonstrate that COX-2 deficiency alone is sufficient to initiate chronic renal failure, and they suggest that COX-2 plays an important role in the maintenance of renal structure and function. This raises the possibility that COX-2 may be a candidate gene for congenital diseases of kidney development in humans. In support of this notion, the renal pathology of the COX-2−/− mice shares some degree of similarity with that associated with perinatal exposure to nonsteroidal anti-inflammatory drugs in humans (15, 34).
The pathogenesis of chronic renal disease (end-stage renal disease) is multifactorial, and the factors that initiate the disease likely differ from those that contribute to its progression. Elucidation of each of these factors in human studies is difficult but can be achieved using genetic mouse models. Our studies provide evidence that renal failure is clearly initiated by COX-2 deletion, whereas its progression is affected by different factors, including genetic background and gender. Comparing the phenotype of various congenic strains within the same gender reveals remarkable strain-dependent variations. Despite chronic renal failure, male BALB/COX-2−/− mice do not develop hypertension or albuminuria, an observation similar to that in COX-2−/− mice on a mixed genetic background (28). Male C57/COX-2−/− mice show mild proteinuria but no hypertension. In contrast, male 129/COX-2−/− mice develop malignant hypertension and overt proteinuria associated with severe renal fibrosis. In a somewhat milder form, a similar pattern of strain-dependent variations was also observed in female mice. Our findings are in good agreement with the report of Ma et al. (25) on the occurrence of hypertension and proteinuria induced by or nephrectomy in the 129/Sv strain compared with C57/BL6 mice. Taken together, these observations demonstrate that the genetic background is an important factor determining susceptibility to the development of hypertension and chronic renal failure in COX-2−/− mice.
Comparing the gender-specific phenotype in the same strains of mice revealed marked differences with substantially more pronounced renal injury and hypertension in male than in female animals, particularly in the 129 strain. The malignant hypertension, overt proteinuria, and severe renal injuries in male 129/COX-2−/− mice contrast remarkably with the mild hypertension, normal proteinuria, and well-preserved renal structures in the female counterparts. In further investigations of this phenomenon in the 129 strain at various postnatal periods, we found that the remarkable gender difference observed in the adult was absent in early postnatal periods. This age-dependent gender difference represents definitive evidence for the role of gender in the progression of renal failure rather than in the development of the primary renal abnormality. Indeed, chronic renal diseases especially those associated with hypertension tend to be more progressive in men than in women (11, 26, 35). Furthermore, the incidence of hypertension-related renal and cardiovascular disease increases sharply after menopause (14).
The mechanism underlying the susceptibility to hypertension and renal failure in the male mice of the 129 strain is not clear. Some evidence suggests that this could be related to the number of renin genes. Two renin genes (Ren-1 and Ren-2, resulting in four renin gene copies) are harbored by 129 mice, whereas C57 and BALB mice only have one renin gene (Ren-1, resulting in two renin gene copies). Ren-1 is expressed at the highest levels in the juxtaglomerular apparatus of the kidney, whereas Ren-2 is highly expressed in the submaxillary gland as well as in other organ systems including the kidney. Wang et al. (6) examined plasma renin concentration in the offspring of crosses of C57BL6/j and 129Ola mice to evaluate the contribution of one or two renin genes to total plasma renin in a controlled genetic background. Plasma renin concentration was 100-fold higher in mice with two renin genes than in those with one renin gene. In addition, Ren-2 has been found to be an androgen-responsive gene and is expected to be more activated in males than in females (13, 38). In line with this notion, genetic deletion of the Ren-1 gene in 129/Sv mice produces hypotension in females but not in males (7), indicating involvement of Ren-2 in a sexually dimorphic mechanism in the control of blood pressure. These findings suggest that enhanced activity of the renin-angiotensin system resulting from the androgen-activated Ren-2 gene may be in part responsible for the susceptibility to the renal phenotype in the male 129 strain. However, this notion is not supported by a recent observation that plasma renin is lower in C57/BL6 mice with one renin gene than in 129/Sv mice with two renin genes (24).
Although blood pressure and urinary albumin excretion varied strikingly with genetic background and gender, we observed only modest variations in plasma BUN. These findings suggest that different renal injury parameters may be under the control of different genetic factors. In agreement with this notion, linkage analysis performed in the fawn-hooded rat has identified that albuminuria and glomerulosclerosis are influenced by RF1 and RF2 loci, whereas hypertension resides at a different locus, called bpfh (5, 30, 36). Future linkage analysis studies on congenic COX-2−/− mice will be necessary to identify the chromosome locus or loci responsible for the phenotypic variations.
The present study permits a comparison between plasma BUN and creatinine as estimates of renal function in mice. In general, plasma BUN in the various strains of congenic COX-2−/− mice correlates with the extent of the renal pathological changes. In contrast, plasma creatinine, measured by the Jaffe method, did not increase in any of the COX-2-deficient strains, including male 129/COX-2−/− mice. A recent study by Dunn et al. (9) documents that plasma creatinine measured by high-performance liquid chromatography but not the Jaffe method accurately reflects renal function in mice. Taken together, the Jaffe method should not be considered as an accurate method for the determination of plasma creatinine in mice.
It should be pointed out that it remains to be determined whether the congenic COX-2 KO mice, especially those of the 129 strain, develop abnormalities in organs other than the kidney. It has been shown that 35% of COX-2 −/− mice on a mixed genetic background of C57/6J and 129/Ola die of patent ductus arteriosus within 48 h after birth, although the majority of the COX-2−/− mice have normal closure of the ductus arteriosus and live to adulthood (23). Furthermore, 3 perinatal death has not been reported consistently in studies of COX-2 −/− mice. Norwood et al. (28) have observed that the ratios of wild-type, heterozygous, and homozygous COX-2 mice on the same mixed genetic background (crossing +/− males with +/− females) were 1:2:1 as expected. Our studies agree with this report in that our breeding records do not reveal obvious perinatal death of 129/COX-2 KO mice. In this regard, the litter size of 129/COX-2 KO colonies (crossing −/− males with +/− females) was only slightly smaller than that of wild-type colonies (8.17 ± 0.4 vs. 9.5 ± 0.95/litter, n = 6 for KO and n = 4 for WT, P > 0.05). Among the progeny derived from crossing male COX-2−/− with female COX-2+/− mice, the ratio of homozygous and heterozygous mice at 1 mo of age was roughly 1:1 as predicted (average number per litter: 4.5 ± 0.5 in −/− group vs. 3.7 ± 0.6 in +/− group). The reason for the variable survival and possibly variable incidence of patent ductus arteriosus in COX-2 KO mice in different studies is unclear but could be again related to differences in genetic backgrounds.
In summary, in the present study we propagated the COX-2 null mutation in three congenic mice strains, 129/Sv, C57/BL6, and BALB/c, using the conventional backcross strategy. All COX-2−/− mice developed abnormalities of postnatal kidney developmental and chronic renal failure, regardless of genetic background and gender. However, the severity of the phenotype is significantly influenced by genetic background and gender, with most severe hypertension and renal injury being observed in the male 129 strain. Our findings reinforce the dominant role of COX-2 in the maintenance of kidney structure and function and identify genetic background and gender as modifying factors for the progression of hypertension and chronic renal failure.
The work was supported by intramural funds of the National Institute of Diabetes and Digestive and Kidney Diseases and National Institutes of Health Grants DK-064981, DK-066592, and HL-079453 (to T. Yang).
We thank Dr. Donald E. Kohan (Div. of Nephrology, Univ. of Utah) for a critical reading of the manuscript.
The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Copyright © 2005 the American Physiological Society


text:
The PokéCommunity Forums
Pokémon: Main Series Games
Third Generation
> Where do you find yourself most in the Hoenn region?
View Full Version :
Where do you find yourself most in the Hoenn region?
December 29th, 2009, 8:10 PM
I spend most of my time on route 119,120,121, and lillycove :D just gotta love that city.
Teh Blazer
December 29th, 2009, 8:19 PM
For some reason, Mauville (gotta love gambling) or Victory Road (training).
December 29th, 2009, 9:24 PM
Definitly Lilycove.I like making Pokeblocks.
December 29th, 2009, 9:37 PM
The whole of Hoenn was just so awesome, and I am bad at choosing among great things.
But right now, just at this moment, I feel like being in Either Mossdeep or Evergrande City, specially over at some cave, sitting and looking at the panoramic view of the water, the waterfall, the huge green grass fields, and forests. Awesome feeling runs through my veins then!
Actually, Evergrande for training, and Mosdeep because back then I thought that the Rocket would actually be active one day, lol.
December 30th, 2009, 2:40 AM
always for some odd reason hang around lillycove aswell
December 30th, 2009, 6:29 AM
With the Daycare right close to there I used to hatch eggs all the time.
December 30th, 2009, 10:36 AM
The beginning of the game. For some reason, the thought of the beginning of RSE makes me want to restart my game, and by the time I have the Go-Goggles, or sometimes Fortree city, I'm ready to restart again. xD
mondays suck
December 30th, 2009, 10:40 AM
Mauville. I'm ALWAYS stuck against Wattson, and later, when I have collected more money, I often return there to get Game Corner TMs like Ice Beam.
Jesus of Suburbia
December 30th, 2009, 12:38 PM
Here, there. Everywhere. I choose no specific place, but rather tend to wander.
Dark Sceptile
December 30th, 2009, 12:39 PM
I am almost always at Victory Road, Safari Zone, or, no surprise, Lilycove City!
December 30th, 2009, 4:26 PM
Mostly Routes 117,Lilycove City,Evergrande City,and finally,Victory Road.
December 30th, 2009, 4:38 PM
Hey, let's gather at Lilycove City then! There's Covelily Hotel, a Trainer Fan club, it's next to the sea, to the Safari Zone, Mt. Pyre etc.
And there you have berry-blending and CONTESTS!!!
Hm... I love that city.. i gotta catch a Staryu, see ya!
January 20th, 2010, 9:17 AM
Technically, one month hasn't passed yet, so...
I spent most of my 999:59+ game hours riding my Mach Bike back and forth past the Daycare Center.
January 21st, 2010, 11:03 PM
Ever Grande, training high-level Pokémon
Lilycove, shopping, contests and my secret base
Battle Frontier, just fun
January 22nd, 2010, 9:20 AM
Lilycove, as that's where the original Magma/Aqua Hideout is. (I'd so re-explore, if Game Freak had let it open, like they did with the Rocket Hideouts.)
Also, the adjacent route contains my secret base, the patch of earth for four Berries and the man in the city that gives you a Berry a day, so, yeah, I'm there a lot.
January 22nd, 2010, 4:36 PM
all depends on what mood i'm in ^_^
January 22nd, 2010, 4:53 PM
I could see myself in Lilycove or Fortree city
January 22nd, 2010, 5:52 PM
Fortree City, Mauville, Lilycove and the routes around those three places are where I usually find myself. Mainly because of the Daycare, where I usually put my Secret Base, and the fact that I enjoy beating up those two reporters for training constantly. :3
January 22nd, 2010, 10:25 PM
I always find myself in Lilycove and Mossdeep City. I love the Department Store and the Space Center is an interesting place where I drift off to on a daily occasion~
January 24th, 2010, 4:11 PM
Hmm...In Emerald the Battle frontier. Now in Ruby hmm...I'm all over the place.Compete in contests..Fulfilling Hoenn Dex...(Just needed Milotic until i lost it 5 years ago.. :( I was like 7 when i completed it almost) Mostly Lilicove.
January 27th, 2010, 6:29 PM
Well, I'm not as big a fan of Lilycove. Sure it's nice, but it's very cliche.
I usually wind up walking into Fortree City, but mainly because my base is there.
I like Mauville for multiple reasons. Mainly because how it is connected to every other place, by being smack dab in the middle. Also Pokerus is found one route over, and the desert is above.
Like many others, I am a fan of Route 120, due to it's rainforest-like atmosphere.
January 27th, 2010, 7:08 PM
In Pokemon Ruby I'm usually around Lilycove (No supprise right there xP) and Rayquazza's tower, for leveling up wise =)
Shadow Chaos
February 2nd, 2010, 8:57 AM
Pokemon League re-battling the Elite Four; or just leveling up my Pokemon in the wild/against trainers.
February 4th, 2010, 2:28 PM
You'll likely find me in the route just before Lilycove. Something about that Route.... attracts me.
February 5th, 2010, 5:56 AM
I'm definitely more in Lilycove City, participiating in Pokémon Contests. =D <-- But that it when I'm "done" with the whole game!
If I'm still going to win gym batches, fight Team Aqua, my rival, doing quests, fight the Elite Four, ect... Then I'm more in the Victory Road training my pokémon, or again in different routes training my pokémon.
Kikaito plush
February 5th, 2010, 6:30 AM
oh oh Diving around sootopias tring to get a shiny clamperal.
February 5th, 2010, 6:50 AM
befor reseting, I was mostly at lilycove, or most of all at the pokemon league re-battling the elite four.
February 5th, 2010, 6:59 AM
Mauville, daycare
the beach at slateport city,
forget lilycove!! i got a beach!!
February 5th, 2010, 7:48 AM
I am always in the battle tower/frontier.
But I also tend to go to Pacifidlog town.
February 5th, 2010, 8:05 AM
Lilycove FTW! :D Loved that place...
February 5th, 2010, 9:07 AM
Simple!!! Mauville for the win. It connects to my most used areas in the game: Daycare, Route 113, Bike Shop, Route *insert name of route between Mauville and Fortree*. My Emerald file has been lost so I can't play it anymore. :(
February 7th, 2010, 1:14 PM
I mostly around Lilycove City and the route between Mauville and Verdenturf (?) Town.
Favorite city and favorite training route, respectively.
February 24th, 2010, 12:25 AM
Everywhere where Gabby&Tv appear. It's better training than Victory Road.
February 24th, 2010, 12:30 PM
^I agree.
Although... I can usually be found in Sootpolis, Lilycove, or Slateport. Those are my favorite cities in the whole game. :D Big(ger) port/water cities ftw!
Okami Chi
February 24th, 2010, 12:34 PM
I too spent hours is Lilycove. I love that place, it is calm there, plus there is much to do there. I love Hoenn.
February 26th, 2010, 7:01 AM
Oh, Battle Frontier! I really want to have all gold symbols.
February 27th, 2010, 10:19 PM
Well, for some reason I always fly to Mauville without even thinking about it. I think since its in the middle I feel like I am putting less stress on my Pelipper when I make her fly every where else. Plus the day care is right there.
February 27th, 2010, 10:23 PM
Mostly Lilycove (I pretend I live there lol). But sometimes I take a "vacation" to Sootopolis =p I always like to pretend that I've retired from pokemon after I've beaten the game ^_^ Although I've noticed that I talk to myself and my Gameboy while I play O_o
February 28th, 2010, 4:05 AM
Mostly Lilycove (Contests, Safari Zone), Mauville (Breeding), and the Battle Frontier.
February 28th, 2010, 10:53 AM
Well , Mauville (Game Corner ) , Victory Road (training) and Battle Tower Idunno , just playin') .
But mostly , I'm gambling ;) .
February 28th, 2010, 11:24 AM
Fortree, I like to pretend that I'm a wood nymph :3
~Hot n' Cold~
March 3rd, 2010, 1:56 PM
Lilycove City
PokeBlocks for Safari Zone, and competiting in contests... my favorite!
Safari Zone
You get a different experience every time you try, and there are so many Pokemon to catch.
Battle Frontier
It's always fun to duke it out at the Battle Factory, or test your love at the Battle Palace.
March 4th, 2010, 3:18 PM
I'm usually wondering all over the place but the majority of the time I'm in the waters.
After all Hoenn was cursed with so much damn water =/
March 4th, 2010, 3:26 PM
I'm always at the battle tower
March 4th, 2010, 6:54 PM
Either n my secret base, or my friends where I can gain a humongous amount of experience. :]
March 5th, 2010, 10:03 AM
Hm... I'm usually in Verdanturf Town or Slateport, there's just something that I love about those two locations! ;)
March 6th, 2010, 11:28 AM
Lets see. Mauville is pretty common because of the day care, then theres the Cycling Road with Slateport at the end for when I'm egg hatching. Then theres Fallabor town, which I hate, but my friend's secret base is there so I often battle him. And like a lot of other people have said, Lilycove is another one. Usually it's for buying Fire Blasts and talking to the move deleter so I can get my Pokemon onto Diamond.
March 6th, 2010, 11:37 AM
When I used to play it,Elite 4. I was always training new Pokemon to fill my Pokedex up. I miss my level 95 Rayquaza ;_;
March 6th, 2010, 2:04 PM
in may secret base! lol love it
March 7th, 2010, 4:48 PM
You would always find me wandering the Battle Frontier. Gotta love that place.
March 10th, 2010, 10:39 PM
Battle Frontier (Emerald), or in other games, wherever Gabby and Ty appeared or the Lilycove for Master Rank contests.
March 10th, 2010, 11:06 PM
underwater. i just loved the looks and the whole idea of it.
March 11th, 2010, 5:21 AM
I think it's Littleroot. I love the song :D
Shiny Shaymin
March 11th, 2010, 6:51 AM
I'm always in the Battle Frontier, probably because there is a lot to do there.
March 17th, 2010, 8:36 AM
Lilycove for shopping. Victory road for training. I like Fortree fo some reason though :D
March 18th, 2010, 5:57 PM
Definitly Lilycove.I like making Pokeblocks.
The whole of Hoenn was just so awesome, and I am bad at choosing among great things.
But right now, just at this moment, I feel like being in Either Mossdeep or Evergrande City, specially over at some cave, sitting and looking at the panoramic view of the water, the waterfall, the huge green grass fields, and forests. Awesome feeling runs through my veins then!
Actually, Evergrande for training, and Mosdeep because back then I thought that the Rocket would actually be active one day, lol.
March 18th, 2010, 6:17 PM
mauville or whatever...
i mainly just play my ruby version for breeding, cuz after i ev train lvling up is a breeze, via the daycare + the mudslide thing
March 18th, 2010, 7:45 PM
Most of the time I'm at Littleroot still, due to the fact that I keep restarting my game if there's somethig I missed earler in the game.
March 20th, 2010, 8:45 AM
I love lilycove...making pokeblocks is always fun.
March 24th, 2010, 12:52 PM
In between mauville and Mosdeep (Fortree and lilycove included)
i just love that entire area (especially Fortree)
March 24th, 2010, 6:13 PM
I always went to Mauville, to force my pokemon to breed. Yaaaayyy.
love like winter
March 24th, 2010, 7:48 PM
Amazingly, I'm rarely at Lilycove. I rend to be found around Mauville. Breeding and Gamblin'! (I'm almost as bad as Setzer from Final Fantasy 6 xD)
The Girl Once named Tracie
March 29th, 2010, 2:21 PM
I tend to hang around the Safari Zone, or The contest halls. The space center is also a place I like, although I can't say why (;
March 31st, 2010, 2:21 AM
By far it HAS to be Lilycove City . Just the peace&silence there is just so....Hypnotizing ;D
March 31st, 2010, 8:11 PM
Route 105 (North of Dewford, where you can find Regice) :/
I like that place.
Also around Pacifidlog...
April 1st, 2010, 12:11 PM
I usually find myself in the routes around either Lilycove or Slateport, not sure why, lol.
April 2nd, 2010, 9:50 AM
The pokemon league becasue i enjoy thrashing the E4 with Absol
April 4th, 2010, 9:25 PM
Since I like breeding IV's, I spend most of my time near the Pokemon Breeders.
April 5th, 2010, 9:07 AM
I'd say the Pokemon League, Victory Road and The Battle Frontier =)
I'm also very often in Lilycove, of course ^^
April 7th, 2010, 9:02 AM
Lilycove, of course. <3 What's not to love?
April 7th, 2010, 1:06 PM
I spend most of my time at the Pokemon League
April 7th, 2010, 1:27 PM
Well, right now in Emerald I'm trying to get at least one of every pokemon I own to level fifty, so I go through the game with a relatively weak party in the beginning and play through, with some... minor changes, until I've leveled that party up. Once I've found my favorites, I'mma pick six and make them beasty-beasts (:
But, I do enjoy that one city with Roxanne. Not sure why? And Dewford. I'm always trying to make them change what's popular, but right now I'm stuck at "Pochyena Love."
I find it funny I've been playing Pokemon for a while and I still can't commit 100% to a party. There are just so many great Pokemanz (:
April 7th, 2010, 3:52 PM
In Sapphire, I spend a lot of time on the route where the Daycare is. In Emerald, I spend a lot of time at the Battle Frontier, as I haven't beaten that yet.
Destiny Bond
April 8th, 2010, 8:10 PM
The elite four place, owning the crap out of people and the pokemon centre for healing etc.
ionbru xp
April 16th, 2010, 8:16 PM
Fortree,Lilycove and the routes between :D
Oh and also my secret base xD
April 16th, 2010, 8:52 PM
I find myself traveling the whole region because I mixed records with so many people who have made bases all over the place :) its a really good way to level up your pokemon...battling friends in their bases that is.
Jack Kentnon
April 17th, 2010, 2:38 AM
Also I spend my time UNDERWATER!! Between routes 124, and 127, because that's the absolutely hawtest thing I have ever done, ever.
I was so incredibly terribly sad when I could not Dive in Fire Red/Leaf Green and Diamond/Pearl/Platinum. De-fog is a terrible waste of space.
I miss my dive...
April 17th, 2010, 5:22 AM
At the moment, Ever Grande City, because I'm training my team against the Elite Four.
April 17th, 2010, 1:23 PM
Early in the game I was always collecting soot. But then It was Battle Frontier or Victory Road and the occasional contest hall.
April 18th, 2010, 2:01 PM
mainly i spent my time around the daycare. i always loved breeding. hand grown pokemon are the best.
April 18th, 2010, 2:14 PM
im mostly in lilycove, because that is where the move deleter is then i migrate!
April 18th, 2010, 3:05 PM
I was always at Fortree cause it was so cool looking :p.
April 19th, 2010, 5:57 AM
The Elite Four. I grab a Pokemon, give it Exp. Share and train it there.
I almost do that with all of my Pokemon's to evolve and level them. :P
April 19th, 2010, 4:15 PM
Shoal Cave. I'm too busy making Shell Bells xD
April 21st, 2010, 2:46 PM
Slateport City and Mossdeep City, I just love the themes~
April 23rd, 2010, 2:00 PM
Fortree,Lilycove and the routes between :D
Same. I've always loved those areas. Especially with the endless rain on the route right after Fortree.
And Lilycove just seems like such a cool city! "Where the land ends and the sea begins."
April 24th, 2010, 3:37 PM
Pokemon League re-battling the elite four and the champ using exp share to level up a Pokemon I just caught.
April 24th, 2010, 4:31 PM
I find myself in the Battle Frontier, I love battling there, even though I have one silver badge... Nothing else =/
But battling is fun.
April 24th, 2010, 5:49 PM
Spent most of my time at Mauville City and Cycling road. FOr eggs and trainer battles. (:
April 24th, 2010, 6:03 PM
always come back to mauville, to get to the berry master. and that electric guy is cool lol
also, the secret base just off the water there has level 100 everything for training ;D
April 28th, 2010, 2:13 PM
Mauville, and the Route thats exits west from it where the daycare centre is, you can always battle the trainers there and it's a great city with the game corner ect. :)
April 28th, 2010, 2:20 PM
Elite four, training up the Pokemon team, atleast, back when I used to play, hopefully getting back into it soon. Also, Secret bases where always fun to hang around in, and customizing constantly. Then, of course, Lilycove, hanging inside of that department store.
April 28th, 2010, 3:54 PM
Mossdeep. Trying to beat Tate&Liza.
Dawn Rules
April 28th, 2010, 6:13 PM
I live in Dewford Town cuz i love living on small islands like Dewford.
April 29th, 2010, 12:15 AM
I spent most of my time in the secret base for training
June 4th, 2010, 12:51 PM
Lilycove :D
i love that city.
I also like the route with the really tall grass & it rains? (the name escapes me)
June 5th, 2010, 5:34 AM
Here, there. Everywhere. I choose no specific place, but rather tend to wander.
Agreed I have know specific place in Hoenn that I like I just love ever single part!Theres no way to choose one,because I go everywhere.
Alpha King
June 5th, 2010, 5:42 AM
Verdanturf and Fortree! I love the quieter, clean, peaceful towns, plus if you wanna go for a battle there cities near those that are quite the competitive type
June 6th, 2010, 11:52 PM
I happen to hang around Battle Frontier, Sootapolis or Mossdeep. As well as the routes near the towns. Just happens that hang around there.. don't know why :P
June 7th, 2010, 12:06 AM
Mostly Mauville, Lilycove, Slateport, Mossdeep, Pacifidlog, the Battle Frontier and Route 119.
Honestly? I love Hoenn so much that I had trouble trying to pick out the places I frequent the most.
June 7th, 2010, 4:37 AM
Berry Master's house. I love growing all those berries.
June 7th, 2010, 5:42 PM
Slateport i love city life
June 10th, 2010, 5:07 PM
I'm usually in Mauville, gambling xD
June 10th, 2010, 5:14 PM
I'm honestly everywhere in Hoenn. There's just so much to see.
June 10th, 2010, 5:46 PM
Lilycove and Mauville. I don't know why. but it's where I usually Fly to. Maybe it's because of the abundant (semi) strong trainers there?
June 11th, 2010, 10:03 PM
Mostly at the Battle Frontier these days. Though for a while I spent most of my time biking from Verdanturf to Route 118 and back, hatching eggs. Also, when I'm feeling nostalgic, I'll fly to Verdanturf to listen to the music there or I'll pay admission to the Oceanic Museum in Slateport and peruse the exhibits while I listen to that beautiful arrangement of the S.S. Anne music.
June 12th, 2010, 1:23 PM
Hmm, mine would have to be Lillycove
June 12th, 2010, 7:01 PM
Route 123, where my base and many rematches are.
June 12th, 2010, 7:03 PM
I always hang around mountain routes because of the music, and I also love going to Petalburg. It's so nice looking, and your dad is in the town too. Plus, it's where my faithful partner, the level 100 Eevee, Tails, hatched. He's on Platinum now though.
June 13th, 2010, 3:13 AM
I like to hang around Mauville, because of the games corner, and well its just generally awesome.
Steve Moore
June 14th, 2010, 11:58 AM
Don't remember what route it was, but I've been catching Spindas and finding out if every single one is actually different.
June 16th, 2010, 5:33 AM
Slateport all the way, great music and best battle tent
June 16th, 2010, 11:48 AM
Probably lillycove. i usually end up spending a lot of time there for no reason at all...
June 16th, 2010, 8:20 PM
Lillycove (shocker), Mauville, I think because it's central with 4 roads, or Slateport, where I stand to check my Pokedex (love the music) and the Oceanic Museum. Verdanturf is my other Dex-checking spot.
June 17th, 2010, 12:57 AM
Mauville and Verdanturf :) egg hatching spot :D
June 18th, 2010, 8:53 AM
Battle Frontier, and the Egg hatching place, never really liked lilycove
June 24th, 2010, 4:21 AM
Battle Frontier is the best!
June 24th, 2010, 5:29 AM
Fortree. My base is there, and i have literally nothing left in the game to do, so i spend my time making my base
o-/< <- this is Bob
June 25th, 2010, 4:30 AM
I like it best in Mossdeep. :P
June 29th, 2010, 5:50 AM
Mossdeep, I like to Dive and hunt for things down there, Pokemon & items alike.
June 29th, 2010, 10:03 AM
Mauville, since it's close to both the Day Care and my secret base.
Air Pichu
June 29th, 2010, 10:15 AM
I actually mostly find myself in the Battle Frontier, and because of that I have lots of BP and I've got the Silver Symbol for the Battle Pyramid and the Gold Symbol for the Battle Dome.
Otherwise I find myself in Lilycove.
Kai Yamato
June 29th, 2010, 9:12 PM
Mauville City. So I can get all those TMs from the Game Corner.
July 2nd, 2010, 8:44 PM
Lilycove, and the battle frontier
July 4th, 2010, 10:14 PM
Like its been said: Egg hatching and Frontier Battling.
Le Creep!
July 5th, 2010, 4:07 AM
I seem to find myself on Mount Pyre to train my weakling Pokémon, other than that, I use Mauville, mostly for it's Game Corner. Sometimes I use Lilycove for shopping and contests.
July 6th, 2010, 3:53 AM
Wherever my secret base is. I do love my secret base. I think it's in...Fortree? It's been awhile...
July 15th, 2010, 3:37 PM
I find myself in Fortree City a lot because of my secret base, and Mauville City because it's close to the DayCare.
July 16th, 2010, 3:32 AM
Let's see, Maybe Mosdeep City. It's just that it sounds special for me. ;D
Agent Clank
July 16th, 2010, 9:51 AM
I'm either at Fortree (I love that place) or Victory Road.
July 16th, 2010, 9:58 AM
Mossdeep; diving beside it is a voyage of discovery. I've had the games since '03 and I bet there's still places to dive I haven't searched.
July 16th, 2010, 1:30 PM
Hmm,where I am at most in Hoenn... I can't really remember much about it,but I think it was mainly Slateport City.
No I take that back. I remember now. I was lways in Mauville City and Lerdanturf Town. I'm not sure why,but that si where I was always at.
July 20th, 2010, 4:31 AM
For the first half of the game, it was Mauville to breed Pokemon. Then later on, after having gained 5 exp shares, and a bunch of Pokemon to evolve to fill up my Pokemon, I started going through the Elite 4. I ended up beating the elite for 350+ times.
July 21st, 2010, 4:07 AM
I used to love to play in my secret base! I would move it from the tree island south of Mauville, the bush right to the south on the west side of Fortree City, or this tree somewhere east of Lilycove. I also loved just taking the water routes around :)
July 21st, 2010, 6:22 AM
Beating up the Elite 4's a$$ everytime to train my weak Pokemons (Like using Exp Share for them until they can battle on their own). Also Battle Frontier's Battle Tower, and the route beside Fallabor (Ash collecting)
July 21st, 2010, 6:28 AM
Mossdeep. I'm attracted to the white rock o.o
July 21st, 2010, 5:17 PM
Mauville due to the fact that there is a game corner and that you can get valuable TMs from them.
July 21st, 2010, 7:20 PM
I spend a lot of time breeding Pokemon so I usually stick around Mauville.
July 24th, 2010, 11:49 PM
I spend a lot of time breeding Pokemon so I usually stick around Mauville.
I do the same thing. I also stayed in mauville before i started breeding.
July 25th, 2010, 2:42 AM
I really liked to visit Fortree City (It's a rare case when you can see a city on trees) and Desert Area.
July 25th, 2010, 3:59 AM
I'm usually around Mauville-Verdanturf to go do contests, breeding and go to the Game Corner once and a while. Other than that I'm usually roaming the eastern water routes and training.
July 25th, 2010, 4:02 AM
Route 119 trying to catch that darn feebas!
July 25th, 2010, 11:34 PM
I like Lilycove the best. Don't know why but I hang around there the most X)
July 29th, 2010, 12:05 AM
I know I'll get flamed for admitting this, but I spend most of my time at the Battle Frontier cloning Master Balls and vitamins. I know, I'm a noob.
July 29th, 2010, 7:37 AM
I just swim around the ocean constantly, I tend to make my secret bases in the caves above Mossdeep, I love shopping at Lilycove and I really enjoy the music while i'm diving (they should make Diving available again ;3; )
July 29th, 2010, 8:19 AM
I spend most of my time riding my bike through Vendaturf town and Mauville City to hatch eggs and to battle to train weak pokemon. There's also the Slateport City - Cycling Road - Mauville City -Vendaturf Town - Mauville City -Cycling Road - Slateport City routine I always go through. And if I'm not there I would be at the 3 locations of the TV reporters OR the Elite Four.
July 29th, 2010, 3:52 PM
I think in emerald they should have kept the spread out contet halls while still adding the battle tents.
it gives more reason to go to different towns rather than just lilycove.
But to have the option to be a coordanator (spelling?) instead of gym fighter would be a unique ability.
July 29th, 2010, 4:16 PM
Lilycove, Battle Frontier, and Mossdeep. Three favorite places in the game right there. Especially Lilycove, I miss the old contests.
July 29th, 2010, 4:35 PM
I dont think i ever go to mossdeep anymore =/ just nothing to do there except battle the leaders again.
besides the gym the only other things are team magmas invasion and getting beldum (i wish there was a way to catch more beldum =/ )
oh and that dynamic punch tutor, but i wasted that out of curiocity
July 29th, 2010, 5:38 PM
Route 113, but I never have yet acquired a glass table and chair.
July 30th, 2010, 7:23 AM
I'm at Lilycove City a lot too :D
July 30th, 2010, 9:26 AM
battle frontier :D
especially the battle factory. training pokemon is sooo tiring, especially those EV's
August 2nd, 2010, 3:06 PM
i dont know why, but always mauville
i never go in the game corner, probly for the contests in the town next door, but i just dont fly there for sum reason.
August 3rd, 2010, 6:54 AM
Lilycove city (Emerald). I`m crazy grinding pokeblocks and pokemon contests. (Haha I sure have defeated E4 or where got so much time?)
August 13th, 2010, 9:33 PM
I tend to hang around Mauville. Usually there's someone to battle, and there's always the long path to run for breeding. I go to Lilycove sometimes, but for shopping and contests. [Emerald]
August 16th, 2010, 6:55 AM
Mauville, u'll always find me there, Hatching Eggs,Contest and the game corner :)
Musician of Literature
August 17th, 2010, 9:25 AM
I'd spend my time mostly in the elite 4, because I haven't beaten them on my current Sapphire.
But, I spend my time mostly either in Mt Pyre, because you can get a lot of training done there, plus I love the mt pyre music. (especially when you are taking upon the tiring task of finding a Chimecho), Victory Road, Meteor falls, and Route 120 (Grr Feebas).
August 17th, 2010, 9:47 AM
Battle Frontier.
Not because of the frontier brains, but because I hatch a lot of eggs and I like them to say "Battle Frontier" in the description. X3
Ankoku Flare
August 17th, 2010, 10:40 AM
Route 119, spent hours trying to hunt for a darn feebass Dx
August 17th, 2010, 4:03 PM
Slateport city XD
I love it.
August 17th, 2010, 6:15 PM
Pokemon center. Where else can you trade with other games?
August 18th, 2010, 1:09 AM
littleroot town nah, i'm usually at Mauville mating my pokemanz. XD
August 19th, 2010, 2:29 AM
Battle frountier, More spesipicly the battle tower
August 19th, 2010, 7:52 AM
Hm. Since I restarted started the game up and normally have something other to do..I'm still on my journey, so I don't hang anywhere.
August 19th, 2010, 8:00 AM
Battle Frontier for the battles and what not
Peach Fresca
August 19th, 2010, 8:19 AM
Fortree City. It was near my Secret Base, and I loved riding up and down that city. :D
Blackpaw Stormfeather
August 19th, 2010, 8:26 AM
Most definitely the Battle Frontier. I love it there! ♥
September 14th, 2010, 4:44 AM
By far the Battle Frontier. I didn't know there was much else to do in the game after you've beaten it :P! I've also never caught much more than my team of 3 for the battle frontier that I level up throughout the game, and 2 or 3 HM slaves, so I don't really go around looking for pokemon or hatching them :X.
September 15th, 2010, 9:42 PM
I find myself in Mauville more often than the other cities. Don't know why, but it may have something to do with it having 4 routes branching out from different directions.
September 16th, 2010, 10:32 PM
I have always liked lilycove but I'm probably most in Mauville because I've needed to run through there to get to another route/city.
September 19th, 2010, 5:00 AM
In emerald I'm always at the battle frontier, but in Ruby, I'm always at Lilycove, because I can run to get my berries each day and buy stuff for my base which is nearby and go get berries from the berry master...thats a lot of berries.
Dark Pulse94
September 22nd, 2010, 11:19 PM
I always found myself, for some reason, at Mauville City, whether I was hatching an egg, gambling, resetting my record at the bike track, or searching for the Interviewer, to beat, AGAIN!!! I always seemed to be in Mauville
October 2nd, 2010, 11:36 AM
I spend my time at Route 123 (planting berries), Route 119 (training and going to my secret base) and Fortree City (my favorite City in Hoenn).
October 2nd, 2010, 5:02 PM
I always hang around mountain routes because of the music, and I also love going to Petalburg. It's so nice looking, and your dad is in the town too. Plus, it's where my faithful partner, the level 100 Eevee, Tails, hatched. He's on Platinum now though.
October 3rd, 2010, 10:43 AM
I'm saved at the Battle Frontier in Emerald. Gotta finish it so I can fully beat the game~!
The Garchomper
October 3rd, 2010, 12:53 PM
Battle Frontier mainly not much left to do once you have cought all hoen pokemon
October 16th, 2010, 9:42 AM
Lilycove and Battle Frontier. Im just attracted to lilycove. I remember beating master contests and searching the Safari Zone for like a week nonstop for the LightBall Pikachu. I like the Battle Pike. I wish they bring something like that back...
October 16th, 2010, 11:28 AM
Between Route 117 and Mauville City and on my bike. (Emerald)
Ahh ... trying to hatch some eggs.
October 16th, 2010, 2:15 PM
It's been a long time since I played Emerald, but for some reason, I normally found myself drawn to areas near Mauville City.
October 16th, 2010, 9:46 PM
Mauville City. I go from the neighboring town (haven't actually played in a long time so I can't remember the actual name) at the left to the route on the right. Nice place for hatching eggs, I'll say.
October 16th, 2010, 10:30 PM
Mauville City. I spent hours hatching rattatas trying to get a shiny one. Never did. Ha. xD
October 25th, 2010, 7:52 AM
Mauville and Verndanturf (sp? I spell them like I've always pronounced them in my head which can be a little different than the real pronunciation) for the daycare and breeding, then comes Lillycove for contests and the amazing department store. Oh, and it's right by the Safari Zone.
October 27th, 2010, 1:58 AM
Lilycove, Battle Frontier, different routes, Gyms
Lilycove - Contests I've got 4 Master Rank Ribbons with my Sceptile, Pikachu, Gardevoir and Wailord
Battle Frontier - BEST PART OF THE GAME
Routes - Travelling, doing stuff
Gyms - Rematches
November 14th, 2010, 7:51 AM
Probably Lilycove, since I battle around there. XD;
November 16th, 2010, 8:15 PM
I have a weird attachment to Mauville. I don't do anything, I just go there. Not for the slots, not for the Day-Care, just a strange attachment.
November 17th, 2010, 8:11 PM
Mauville... yes, for the reason everyone is thinking of
REPLEKIA has an addiction
Also Lilycove, because I love Staryu :3
November 19th, 2010, 8:20 AM
Lilycove and Battle Frontier, battling is fun! ;3
December 3rd, 2010, 11:20 AM
I usually end up in either Mauville or the route to the right of Fortree.
December 3rd, 2010, 1:22 PM
I find myself in Mossdeep most often. No reason, like someone said above this, just a strange attachment.
December 3rd, 2010, 1:49 PM
The Battle Frontier and the Day Care Centre. Those two places seem to go hand in hand for obvious reasons.
~*!*~Tatsujin Gosuto~*!*~
December 5th, 2010, 12:25 PM
I usually find myself most near the Battle Frontier in Emerald version and as for Ruby and Sapphire, Slateport City because of the Master Rank Hall for the Pokemon Contest and because there is a huge department store there and I tend to by a lot of useless items
December 6th, 2010, 6:07 PM
Well it usually depends on what I was trying to accomplish or complete the last time I've played the game. Usually I'm trying to win each rank of the contests (not going to lie, best contests made) or battling against the Elite Four to level up my random Pokémon used for contests quicker, in order to obtain the moves I need for each type. They all revolve around contests mainly so my save points are usually in front of the Elite Four or inside a Pokémon Contest building. However this only goes for my Sapphire version most of the time.
For Emerald, it's all about the battling. With the Battle Frontier, I'm found in random areas training to battle each Frontier Brain with different sets of teams for each one. So usually it depends where I was left training, otherwise I'm in the Pokémon Center of the Battle Frontier. XD;
♠Dawn Rayne♠
December 6th, 2010, 7:33 PM
The area in between Mauville city and Verdanturf town.
December 8th, 2010, 3:02 AM
I would have to say Lilycove, I definitely love to make pokeblocks. :D


text:
Service Magic
Headquartered in Golden, Colorado, ServiceMagic is the nation's leading website connecting consumers with prescreened, customer-rated service professionals. Since 1999, ServiceMagic has matched millions of consumers with service professionals, resulting in billions of dollars in various home improvement projects for bathroom remodelers, maid services, handymen and many more. ServiceMagic was recently named Colorado Technology Company of the Year and draws nearly four million unique visitors to its website each month. Each of ServiceMagic's professionals is selected from a rigorous screening process, including state-level licensing. Although best known for home improvement services, such as remodeling, roofing or painting, ServiceMagic also provides services for cleaning, photography, senior care, event planning, catering and videography.
Service Magic: 1-866-943-7520


text:
Level II Classes
Classes start in September, 2015
Application Deadline is TBD
If there are not enough Level 2 participants this class term, there will be polarity review classes scheduled. Check back here for this possibility.
In Level II Classes You will learn:
- Energy balance theory
- Theory of healing
- Deepening of the 5 Element Theory
- Theory of energy and body structure
- Theory of energy and the nervous system
- Therapeutic presence skills
This course meets one weekend per month for four months. Classes begin in September.
Learn more about Polarity Therapy classes.
Class Instruction and Private Supervisions
Two, one-hour supervisions with the instructor are scheduled between each class and are included in the tuition.
Dates and Times
Saturday and Sunday from 9 a.m. to 5:30 p.m. each day.
- September TBD
- October TBD
- November TBD
- December TBD
Class Location
World Class Institute of Martial Arts, 31839 Eight Mile Road, Livonia, MI 48152, at end of upstairs hallway.
Please do not call the World Class Institute about this class. Call the Polarity Center at (313) 647-0038.
TBD with a $65 application deposit to hold your place. Payment plans are available.
There are two ways to register and pay:
- Register and pay online with PayPal.
- Download, print and fill out the application form. Mail the form and check to the Polarity Center.


text: Hi, I'm trying to use LVM because of its snapshot and extend/reduce feature. But I found that they have some problem so I started debugging and found something. Please verify that and do further debugging. lvreduce calls pv_release_pe() to mark unnecessary PEs. while doing that it does following calculation. pv_release_pe() { ............... pe_index = ( vg->lv[i]->lv_current_pe[p].pe - LVM_VGDA_SIZE ( vg->pv[pv_num]) / SECTOR_SIZE) / vg->pe_size; ............... } I don't know why you don't just use p instead of long calculation but problem is vg->lv[i]->lv_current_pe[p].pe is not 8192 bytes aligned and first pe value is bigger than 8192. In my case it was 8352. And it frees worng PE. If I subtract 1 from pe_index or just use p then it works fine. So questions Why lv_current_pe[x].pe is not 8192 aligned, Is it intended? does it mean PEs are not aligned in physical disk? Why does the long calculation is needed only to get the same value with p? when is the case that pe_index is different from p? scattered PEs in one VG? Thanks, Soohoon.


text:
Its always hard to write about yourself, battling between not exaggerating your good qualities too much while still trying to remain appealing. I am a very loyal and compassionate person, with an expansive sense of humor and play, and an appreciation for wit (If you can't laugh at yourself life isn't fun). I am honest to a fault, easily excitable, strategic and hardworking while being a terrible procrastinator. I love cooking, running and other athletics, learning or exploring something new, and pretty much anything as long as I'm with good company. I find great satisfaction in others success and enjoyment, especially when I have helped them to find it. I'm currently working full-time/part-time while attending UCSD part-time/full-time. My life is an open book, you just have to turn the pages. I like 'real' (personal or intimate) conversation and will answer *practically* any question someone asks me.
Recently I've heard from several people that the first thing they noticed about me is my 'charisma' - and the narcissist in me had to share that :)
I've very easy to like (If a few mischievous comments don't throw you for a loop lol). I'm almost always happy, animated, and enjoying myself - and ensuring everyone around me is as well.
interests in everything from Ren Fairs to dnd.
Books: A few too many Econ books lol - the last was "the number" - I also tend to read the new york times/economist/pulse every few days to keep up with current events. One of the last good things i read was Sybil, and i found it absolutely fascinating. I really enjoy a good fantasy or sci-fi book when i have the time, and I've read a ridiculous number of them. Favorites have been: wheel of time series by Robert Jordan , Ender' game/shadow of the Hegimon, anything by RA Salvatore or Anne Rice, the Dresdon Files by Jim Butcher, Lord of the Rings/Hobbit, Harry Potter, Neuromancer, Shogun, and many more.
Music: I like any music with interesting lyrics or that you can just relax to - note - not a fan of rap :(
Bands I actively listen too: Linkin park, the killers, Coldplay, perfect circle, blink 182, foo fighters, Marilyn Manson, offspring, system of a down, MSI, bloodhound gang, Aquabats, and varied others of similar nature.
Movies: kill bill 1&2, princess bride, serenity, count of monte cristo, Shawshank redemption, American History X, Lord of the rings 1-3, Dune, pulp fiction, sin city, Animal house, anything monty python, legend, princess mononoke, ghost in the shell, blade runner, dark knight, 300, Avatar, Iron Man, The prestige, from dusk till dawn, Young Frankenstein, Blazing Saddles
... when I think of more I will add them :)
TV: true blood,
venture brothers, Archer, Dexter, Burn Notice,
White Collar, [South Park]], Two and half men[, stargate
universe, big bang theory,firefly, robot chicken, .....
just to name a few. I'm also a huge fan of anime and have seen most of the good things it has to offer: beebop, outlaw star, death note, bleach, FMA, FLCL, Gundam seed/wing, Hellsing, etc.
I figured I'd throw in a Video Game section as well lol, since I've spend more time doing that than movies or music. I have always been a huge halo fan though its one of the few FPS games I've enjoyed playing. I've played a decent number of MMO's and RPG's, I loved FF10,EQ2, morrowind, oblivian, fable, dragonage, Mass effect 1&2, return to krondor, Arcanum, Baldurs gate (I,II, throne of bhal) and others. Dota was a constant companion during my early college years! I currently only play LOL and SWTOR on any kind of regular basis, and only when friends invite me to. Sure I'm forgetting something but that's already a pretty impressive list lol....or maybe impressive is the wrong word lol.
Food: Oooo this is hard.... I love food and I love
cooking. About half the reason i run is so I don't really have to
watch what i eat. I love Mexican food, most Asian cuisine, I
especially love Sushi and Japanese food (and beer/sake lol),
fondue, and so much more. I love good cheese... breads ... and wine :) Good beers are a true wonder to be enjoyed with friends, I know wine (having been raised with it) but I prefer a good beer to a glass of wine most of the time). As a cook - there are many things I love making - mostly because I love eating them. If you even get a chance to eat my cooking, likely it will be one of the following dishes (i can make almost anything I just have some dishes I make VERY well) Chicken dumpling soup, thai peanut chicken stir fry, Lasagna, rosemary potatoes, fried rice, pot pies, Tuscan Bean Soup, Broccoli Beef, Bow-tie casserole, and anything breakfast related, my coffee cake is to die for :)
Something tasty to eat, probably that I cooked
Somewhere to run or bike, exercise is very important to me
A long hot shower after a long day. At least 30 mins or more
A never-ending-supply of books to read
Friends to share everything with :)
(I know this makes 7-8 but my laptop/android phone are vital)
(and 9 would have to be a good beer or glass of wine lol)
What new recipes to try, or old recipes i can improve on, often about why I'm not sleeping yet...especially once it hits about 3am lol
So go ahead and ask- its no fun if I just tell you in advance :)
I am open to meeting people for any number of reasons - you can never have too many friends or meet too many new people :)
My only Criteria are your being Trustworthy and hopefully Fun :)
In terms of Dating....
I'm an absolute sucker for a girl who's a bit of a tomboy ( gamers a bonus ), throw in likes to run and cook and I am sold.... :)
I'm looking for someone Playful: who can make their own fun, Intelligent and Witty: willing to banter at a moments notice, Positive: always making sure the cup is more than 1/2 full, Compassionate, Down to earth, and ..... I'm making a long list aren't I? When it comes down to it I'm looking to fall in love again with a girl who will love and appreciate me as much as I will her.


text:
Pinwheel Afghan/Solid by Annie Dempsey
Welcome! You are browsing as a guestWould you like to see 48 projects made from this pattern and much more? create a free account What am I missing?
© 1996 Oat Couture
by MiniLaura Flickr
by centrepullball Flickr
by purlsbeyondprice Flickr
by Jennknitter Flickr
Pinwheel Afghan/Solid
This pattern is available from patternfish.com for $6.00.
Pattern Description The ever-popular round baby blanket, worked with short row technique. The solid color version is knit in garter stitch.*
Instructions included for dk and worsted weight yarns.
Materials, Double Knitting:
1350 yds. double knitting weight yarn
Knitting needles size 6 (or size needed to obtain gauge)
1 marker
Gauge: 22 sts, 30 rows = 4" in stockinette st.
Materials, Worsted Weight:
1000 yds. worsted weight yarn
Knitting needles size 8 (or size needed to obtain gauge)
1 marker
Gauge: 20 sts, 28 rows = 4" in stockinette st.
For more information, see: http://www.patternfish.com/patterns/9703


text:
MangaReaper is an automated tool to download and manage mangas for Linux, created around Comix viewer (and its various forks).
MangaReaper let the user subscribe to various mangas in a completely automated way, and periodically download the new chapters available. It supports many download sites, such as mangareader, mangafox, or eatmanga.
MangaReaper organizes the downloaded chapters in various libraries of Comix, and let the user manage them. It includes many features such as automatically deleting mangas after a certain number of days or chapters, or viewing the list of the unread chapters.
This tool aims to be as flexible and configurable as possible. Even though it's a bash script, all the interactions are done graphically, thanks to Zenity's fork, Yad.
*** Update ***: A new portable Perl / Gtk3 version is currently under development. The bash version ow serves just as a demo.
- Managing mangas and organizing them in various libraries.
- Automated subscribing to new mangas (all the user has to do is to provide the name of a manga, and eventually the starting chapter, and MangaReaper does the rest).
- Automated downloading of mangas online from various servers.
- Interface to manually download mangas, only requiring its name and the number of the chapter.
- Possibility to activate or deactivate downloading sources at will.
- Option to add an icon in the system tray, either permanently or when new mangas are available, with a fully customizable behaviour.
- Full integration of viewers such as Comix (and its forks).
- List of the newly downloaded mangas that are not yet read.
- Automated deletion of mangas after a certain number of days or chapters (customizable, with the possibility to individually change the settings for every manga).


text:
Study by the NACS/ Coca-Cola Retailing Research Council (CCRRC) identifies five new platforms that can drive convenience retail growth. By Erin Rigik, Associate Editor. A newly released report from the NACS/Coca-Cola Retailing Research Council (NACS/CCRRC) is providing insights into what motivates shoppers to spend more of their hard-earned dollars inside convenience stores. "We began the
CCRRC Study Unveils Growth Opportunities for C-Stores
NACS/CCRRC Releases Report On Shopper Motivations
Study identifies five compelling new platforms that can drive convenience retail growth. Convenience retailers seeking a profitable path to the future now have five compelling growth platforms to explore, following recommendations offered in the final section of a new NACS /Coca-Cola Retailing Research Council (NACS / CCRRC) study posted on www.ccrrc.org. "C-Growth: Using Shopper Research
Divine Disruption
Here's an entirely plausible scenario: At around 8 a.m. on a weekday, customers are lined six deep in front of the only open register at your suburban convenience store. The line has screeched to a halt because a deliveryman running late has flanked the clerk at the register and asked her to sign off on


text:
I take Celexa 20mg daily. I really need to quite smoking but need to know of any adverse reactions to taking a non-smoking pill like Chantix with my Celexa.READ MORE
Can you take a non-smoking pill like Chantix while taking Celexa
Hi Sue!
My best advice would be to ask this question of your doctor or even call your local pharmacist to see if there are any interactions between these two drugs.
I will point you to some literature I have found to research your question. First of all...you might want to visit the official site for Chantix which you can find here. They do state that you need to be aware that Chantix can cause depressive symptoms. A similar question was asked on Health Central about Champix and you can read the answers here.
Here is a site discussing possible drug interactions which you may find here.
The following site probably has the most interesting information of all. This is a thread of comments about the use of Chantix and Champix while taking anti-depressants. You may find this very candid discussion here.
I think anyone who tries to quit smoking has a ton of patience and courage. My three pack a day mother tried to quit smoking years ago and had some success going to a hypnotist.
I wish you the best of luck. Do be cautious and ask your doctor or pharmacist first before taking the two drugs together. Thank you for your question!
Drugs.com has a utility called interaction checker. When you put in the name of the drug it will tell you what drugs wont go with what you are taking. Handy little utility.
You might want to look at the long list for celexa.
It doesnt say anything about chantix. Through experience with chantix. I would say its a one shot deal you have to decide to complete the task, but if you suddenly realize that you are crying. You should stop. It can increase depressive feelings. My doctor asked me to take lexapro(celexa cousin) but I took it with st johns wort and it didnt go well. I recently quit cold turkey for 4 weeks but then had an anxiety attack cause I quit the st johns wort. Almost ready to do it again. They say you truelly only need 3 days of not smoking to get over the hill. It would be a lot better if they just locked us in a room for a week in many different aspects.
Anyway the chantix program seemed to me that it only truelly worked the first time. When I tried it the second time I couldnt tell if it was doing what it was supposed to.
I met a lady that thought that it was ok to take the chantix for months. This is an unnatural chemical attack on the brain. Keep in touch with your doctor while taking it. If you contact the people at chantix they werent much help to me.
Good luck,
PatREAD MOREYou should know Answers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Content posted by community members does not necessarily reflect the views of Remedy Health Media, which also reserves the right to remove material deemed inappropriate.DISPLAY TEXTLINK URL


text:
Related Names
Name Origins
The mountainous borders of Spain contain the Origins of the prestigious surname Marquez.[1][2] The Spanish version of the name was first found in Castile, predominant among the Christian kingdoms of medieval Spain.
The French surname of MARQUEZ was a French topographic name for the dweller at the boundary mark, or one who came from Marck (frontier district) in France.[3] This name is also spelt MARQUETTE and MARQUET. A notable member of the name was Jaques MARQUETTE (1637-75) the French Jesuit missionary and explorer, born in Laon. He was sent in 1666 to North America, where he brough Christianity to the Ottawa Indians around Lake Superior, and went on expeditions which discovered and explored the Mississippi (1673). He wrote an account of the journey. Another noteworthy person was Pierre Albert MARQUET (1875-1947), the French artist, born in Bordeaux. After initial hardships, he became, primarily an Impressionist landscape painter and travelled widely, painting many pictures of the Seine, Le Havre and Algiers.[4]
Some of the first western settlers of this family name or some of its variants in North and South America were:
Marquez as a Surname
There are 49,284 unique Marquez surnames in the United States.
Name Ranking:
Top States for last name Marquez:
Most Popular first names for Marquez:
Most searched for Marquez in the United States in January 2009:
Source: WhitePages.com
External Links


text:
As reported in the Arizona Daily Star on Wednesday, a judge in Pima County Superior Court has issued a cease and desist order to attorneys working on behalf of convicted killer Pamela Phillips.
Judge Richard Fields, who presided of Phillips' first-degree murder trial, ordered her defense team from contacting jurors from the trial.
Phillips was convicted of first-degree murder and conspiracy to commit first-degree murder for the 1996 killing of her ex-husband Gary Triano.
Attorney Paul Eckerstrom with the Pima County Legal Defender's officer has filed motion to vacate the judge's order.
In the motion, Eckerstrom said the cease and desist order prevents the defense from investigating possible juror misconduct.
"Due to the Court's Order, the Defense has been thwarted from continuing the necessary investigation that includes seeking voluntary witness interviews of discharged jurors for the Motion for New Trial...," Eckerstrom wrote.
Eckerstrom also wrote that the order unfairly pertains only to the defense.


text:
Already a customer?
New customer?
As a registered user you can create a list of favorite products and access orders history and tracking.Register
Evans BD22EMAD - EMAD series Clear 22";
single ply of 10mil film providing an ideal balance of punch, power and low-end;
two Externally Mounted Adjustable Damping (EMAD) system and single patch included.
€ 48,00
VAT included
Plus shipping
In stock
Need more information or advice on this product?
You can contact us by telephone from Tuesday to Saturday from 9:00 to 12:30 and 15:00 to 19:30 at number 0423 303236, or you can use the form below to send us an email, we'll get back in 24/48 hours.
We ship to most EU countries in 48/72h. Hold on a little more if you buy during weekend or holidays.
Buy what you want! Shipping costs are fixed at 20€
Choose your payment, we accept PayPal and credit cards but also wire transfers.
You're safe!
The website is protected by a Digicert SHA-256 certificate.


text:
Clue: 'Angie' actor Stephen
We have 1 answer for the clue 'Angie' actor Stephen. See the results below.
Possible Answers:
Related Clues:
- New Deal proj.
- F.D.R. agcy.
- U.S.D.A. power agcy.
- New Deal prog.
- Actor Stephen
- "The Crying Game" star
- Best Actor nominee of 1992
- "Interview With the Vampire" co-star
- Stephen of "The Crying Game"
- Mens ___ (criminal intent)
Last Seen In:
- King Syndicate - Premier Sunday - August 05, 2007
Found an answer for the clue 'Angie' actor Stephen that we don't have? Then please submit it to us so we can make the clue database even better!