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HEREFORDSHIRE'S award-winning Home Farm – 2013's Wye Valley Area of Outstanding Natural Beauty – will open its gates to the public on Sunday (June 8) as part of Open Farm Sunday.
The Welsh Bicknor farm scooped last year's prize – which recognises efforts to conserve and enhance the beauty of an area – and entrees are now being accepted for the 2014 competition.
"We just want to hear about those examples of great farming practice that enhance the landscape," said Andrew Nixon, Wye Valley AONB development officer.
"Farms can be nominated for all sorts of reasons, they may demonstrate excellent examples of building restoration or conservation of drystone walls, care for wildlife habitats or conserve rare breeds or contribute to community life."
Those looking to check out the gold standard, or just enjoy the Herefordshire countryside, will be able to take a 2.5-mile walk around Home Farm, on the Courtfield Estate.
The winning farm in 2014 will collect £400 in prize money – with cash prizes also awarded to second and third spots – and the farm award trophy made by local sculptor Steve Bluett.
The deadline for nominations is July 11 and the winner will be announced at the Monmouthshire Show on August 28.
Nominations need to be written up on a single side of A4 paper, explaining the special contribution the farm has made and including your name, address, telephone and email details, and sent to AONB Farming Awards, FREEPOST SWC 4106, MonmouthNP25 3ZZ.


text: Todd Cochran previously ran the website The Dumbing of America. His work has also appeared on MTV, CBS Radio and in NME and SPIN Magazine. A Detroit native, she studied literature and journalism at Wayne State University and now lives in Texas. You can follow him on Facebook and Twitter.

subset: commoncrawl


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Release Notes: This version no longer crashes if it starts without KMix
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text:
Combinatorial chemistry
Combinatorial chemistry comprises chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process. These compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software.[citation needed] Combinatorial chemistry can be used for the synthesis of small molecules and for peptides.
Strategies that allow identification of useful components of the libraries are also part of combinatorial chemistry. The methods used in combinatorial chemistry are applied outside chemistry, too.
Synthesis of molecules in a combinatorial fashion can quickly lead to large numbers of molecules. For example, a molecule with three points of diversity (R1, R2, and R3) can generate possible structures, where , , and are the numbers of different substituents utilized.[citation needed]
The basic principle of combinatorial chemistry is to prepare libraries of very large number of compounds then identify the useful components of the libraries.
Although combinatorial chemistry has only really been taken up by industry since the 1990s,[citation needed] its roots can be seen as far back as the 1960s when a researcher at Rockefeller University, Bruce Merrifield, started investigating the solid-phase synthesis of peptides.
In its modern form, combinatorial chemistry has probably had its biggest impact in the pharmaceutical industry.[citation needed] Researchers attempting to optimize the activity profile of a compound create a 'library' of many different but related compounds.[citation needed] Advances in robotics have led to an industrial approach to combinatorial synthesis, enabling companies to routinely produce over 100,000 new and unique compounds per year.[citation needed]
In order to handle the vast number of structural possibilities, researchers often create a 'virtual library', a computational enumeration of all possible structures of a given pharmacophore with all available reactants.[1] Such a library can consist of thousands to millions of 'virtual' compounds. The researcher will select a subset of the 'virtual library' for actual synthesis, based upon various calculations and criteria (see ADME, computational chemistry, and QSAR).
Combinatorial synthesis – peptides[edit]
The combinatorial "split-mix synthesis"[2] is based on the solid phase synthesis developed by Merrifield.[3] If a combinatorial peptide library is synthesized using 20 amino acids (or other kinds of building blocks) the bead form solid support is divided into 20 equal portions. This is followed by coupling a different amino acid to each portion. The third step is mixing of all portions. These three steps comprise a cycle. Elongation of the peptide chains can be realized by simply repeating the steps of the cycle.
The procedure is illustrated by the synthesis of a dipeptide library using the same three amino acids as building blocks in both cycles. Each component of this library contains two amino acids arranged in different orders. The amino acids used in couplings are represented by yellow, blue and red circles in the figure. Divergent arrows show dividing solid support resin (green circles) into equal portions, vertical arrows mean coupling and convergent arrows represent mixing and homogenizing the portions of the support.
The figure shows that in the two synthetic cycles 9 dipeptides are formed. In a third and fourth cycles 27 tripeptides and 81 tetrapeptides would form, respectively.
The "split-mix synthesis" has several outstanding features:
- It is highly efficient. As the figure demonstrates the number of peptides formed in the synthetic process (3, 9, 27, 81) increases exponentially with the number of executed cycles. Using 20 amino acids in each synthetic cycle the number of formed peptides are: 400, 8,000, 160,000 and 3,200,000, respectively. This means that the number of peptides increases exponentially with the number of the executed cycles.
- All peptide sequences are formed in the process that can be deduced by combination of the amino acids used in the cycles.
- Portioning of the support into equal samples assures formation of the components of the library in nearly equal molar quantities.
- Only a single peptide forms on each bead of the support. This is the consequence of using only one amino acid in the coupling steps. It is completely unknown, however, which is the peptide that occupies a selected bead.
- The split-mix method can be used for the synthesis of organic or any other kind of library that can be prepared from its building blocks in a stepwise process.
In 1990 three groups described methods for preparing peptide libraries by biological methods[4][5][6] and one year later Fodor et al. published a remarkable method for synthesis of peptide arrays on small glass slides.[7]
A "parallel synthesis" method was developed by Mario Geysen and his colleagues for preparation of peptide arrays.[8] They synthesized 96 peptides on plastic rods (pins) coated at their ends with the solid support. The pins were immersed into the solution of reagents placed in the wells of a microtiter plate. The method is widely applied particularly by using automatic parallel synthesizers. Although the parallel method is much slower than the real combinatorial one, its advantage is that it is exactly known which peptide or other compound forms on each pin.
Further procedures were developed to combine the advantages of both split-mix and the parallel synthesis. In the method described by two groups[9][10] the solid support was enclosed into permeable plastic capsules together with a radiofrequency tag that carried the code of the compound to be formed in the capsule. The procedure was carried out similar to the split-mix method. In the split step, however, the capsules were distributed among the reaction vessels according to the codes read from the radiofrequency tags of the capsules.
A different method for the same purpose was developed by Furka et al.[11] is named "string synthesis". In this method the capsules carried no code. They are stringed like the pearls in a necklace and placed into the reaction vessels in stringed form. The identity of the capsules, as well as their contents, are stored by their position occupied on the strings. After each coupling step the capsules are redistributed among new strings according to definite rules.
Combinatorial synthesis – small molecules[edit]
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Dynamic combinatorial chemistry[12][13][14] uses a different approach for the synthesis of compound libraries. Dynamic combinatorial libraries are generated from an array of reactive building blocks that can react with one another through reversible reactions. In this case, the product distribution in the library is determined by the relative stability of the members. A component of the library can be stabilized by adding a template than can form non-covalent bonds with it. This alters the product distribution and favors the formation of the stabilized library member at the expense of the components.
Deconvolution and screening[edit]
The synthesized molecules of a combinatorial library are 'cleaved' from the solid support and mixed into solution. In such solution, millions of different compounds may be found. When this synthetic method was developed, it first seemed impossible to identify the molecules, and to find molecules with useful properties. Strategies of purification, identification, and screening were developed, however, to solve the problem. All these strategies are based on synthesis and testing of partial libraries.
The earliest strategy, the "Iteration method" is described in the above-mentioned document of Furka notarized in 1982. Identification of the sequence of the active peptide involves removal of samples after each coupling step of the synthesis before mixing. These samples are used in the step-by-step identification by testing and coupling starting at the N-terminus.
The "Positional scanning" method[15] is based on synthesis and testing of a series of sub-libraries in which a certain sequence position in all components is occupied by the same amino acid.
"Omission libraries"[16][17] in which a certain amino acid is missing from all peptides of the mixture as well as "amino acid tester libraries"[18] that contain those peptides that are missing from the omission libraries can also be used in the deconvolution process.
If the peptides are not cleaved from the solid support we deal with a mixture of beads, each bead containing a single peptide. Smith and his colleagues[19] showed earlier that peptides could be tested in tethered form, too. This approach was also used in screening peptide libraries.[20] The tethered peptide library was tested with a dissolved target protein. The beads to which the protein was attached were picked out, removed the protein from the bead then the tethered peptide was identified by sequencing.
A somewhat different approach was followed by Taylor and Morken.[21] They used infrared thermography to identify catalysts in non-peptide tethered libraries. When the beads were immersed into a solution of a substrate. the catalyst containing beads were glowing because of the heat evolved in them and could be picked out.
The components of combinatorial libraries can also be tested one by one after cleaving them from the individual beads.
If we deal with a non-peptide organic libraries library it is not as simple to determine of the identity of the content of a bead as in the case of a peptide one. In order to circumvent this difficulty methods were developed to attach to the beads, in parallel with the synthesis of the library, molecules that encode the identity of the compound formed in the bead. The attached molecules may form peptide[22][23] or nucleotide[24][25] sequences or a binary code.[26]
Materials science[edit]
Materials science has applied the techniques of combinatorial chemistry to the discovery of new materials. This work was pioneered by P.G. Schultz et al. in the mid nineties[27] in the context of luminescent materials obtained by co-deposition of elements on a silicon substrate. His work was preceded by J. J. Hanak in 1970[28] but the computer and robotics tools were not available for the method to spread at the time. Work has been continued by several academic groups[29][30][31][32] as well as companies with large research and development programs (Symyx Technologies, GE, Dow Chemical etc.). The technique has been used extensively for catalysis,[33] coatings,[34] electronics,[35] and many other fields.[36] The application of appropriate informatics tools is critical to handle, administer, and store the vast volumes of data produced.[37] New types of Design of experiments methods have also been developed to efficiently address the large experimental spaces that can be tackled using combinatorial methods.[38]
Diversity-oriented libraries[edit]
Even though combinatorial chemistry has been an essential part of early drug discovery for more than two decades, so far only one de novo combinatorial chemistry-synthesized chemical has been approved for clinical use by FDA (sorafenib, a multikinase inhibitor indicated for advanced renal cancer).[39] The analysis of poor success rate of the approach has been suggested to connect with the rather limited chemical space covered by products of combinatorial chemistry.[40] When comparing the properties of compounds in combinatorial chemistry libraries to those of approved drugs and natural products, Feher and Schmidt[41] noted that combinatorial chemistry libraries suffer particularly from the lack of chirality, as well as structure rigidity, both of which are widely regarded as drug-like properties. Even though natural product drug discovery has not probably been the most fashionable trend in pharmaceutical industry in recent times,[citation needed] a large proportion of new chemical entities still are nature-derived compounds,[citation needed] and thus, it has been suggested that effectiveness of combinatorial chemistry could be improved by enhancing the chemical diversity of screening libraries.[42] As chirality and rigidity are the two most important features distinguishing approved drugs and natural products from compounds in combinatorial chemistry libraries, these are the two issues emphasized in so-called diversity oriented libraries, i.e. compound collections that aim at coverage of the chemical space, instead of just huge numbers of compounds.[citation needed]
Patent classification subclass[edit]
In the 8th edition of the International Patent Classification (IPC), which entered into force on January 1, 2006, a special subclass has been created for patent applications and patents related to inventions in the domain of combinatorial chemistry: "C40B".
See also[edit]
- Combinatorics
- Cheminformatics
- Combinatorial biology
- Drug discovery
- Dynamic combinatorial chemistry
- High-throughput screening
- Mathematical chemistry
- Molecular modeling
- ^ E. V.Gordeeva et al. "COMPASS program - an original semi-empirical approach to computer-assisted synthesis" Tetrahedron, 48 (1992) 3789.
- ^ Á. Furka, F. Sebestyen, M. Asgedom, G. Dibo, General method for rapid synthesis of multicomponent peptide mixtures. Int. J. Peptide Protein Res., 1991, 37, 487-493.
- ^ Merrifield RB, 1963 J. Am. Chem. Soc. 85, 2149.
- ^ J. K. Scott and G. P. Smith Science 1990, 249, 404.
- ^ S. Cwirla, E. A. Peters, R. W. Barrett and W. J. Dower Proc. Natl. Acad. Sci. USA 1990, 87, 6378.
- ^ J. J. Devlin, L. C. Panganiban and P. E. Devlin Science 1990, 249, 404.
- ^ Fodor SP, Read JL, Pirrung MC, Stryer L, Lu AT, Solas D, 1991. Light-directed, spatially addressable parallel chemical synthesis. Science 251, 767-73.
- ^ H. M. Geysen, R. H. Meloen, S. J. Barteling Proc. Natl. Acad. Sci. USA 1984, 81, 3998.
- ^ E. J. Moran, S. Sarshar, J. F. Cargill, M. Shahbaz, A Lio, A. M. M. Mjalli, R. W. Armstrong J. Am. Chem. Soc. 1995, 117, 10787.
- ^ K. C. Nicolaou, X –Y. Xiao, Z. Parandoosh, A. Senyei, M. P. Nova Angew. Chem. Int. Ed. Engl. 1995, 36, 2289.
- ^ Á. Furka, J. W. Christensen, E. Healy, H. R. Tanner, H. Saneii J. Comb. Chem. 2000, 2, 220.
- ^ Lehn, J.-M.; Ramström, O. Generation and screening of a dynamic combinatorial library. PCT. Int. Appl. WO 20010164605, 2001.
- ^ Corbett, P. T.; Leclaire, J.; Vial, L.; West, K. R.; Wietor, J.-L.; Sanders, J. K. M.; Otto, S. (Sep 2006). "Dynamic combinatorial chemistry". Chem. Rev. 106 (9): 3652–3711.
- ^ Lehn , J. - M. ( 2007 ) Chem. Soc. Rev . ,36 , 151 – 160.
- ^ Á. Furka, F. Sebestyén WO 93/24517.
- ^ T. Carell, E. A. Winter, J. Rebek Jr. Angew. Chem. Int. Ed. Engl. 1994, 33, 2061.
- ^ E. Câmpian, M. Peterson, H. H. Saneii, Á. Furka Bioorg. & Med. Chem. Letters 1998, 8, 2357.
- ^ E. Câmpian, J. Chou, M. L. Peterson, H. H. Saneii, Á. Furka, R. Ramage, R. Epton (Eds) In Peptides 1996, 1998, Mayflower Scientific Ltd. England, 131.
- ^ J. A. Smith J. G. R. Hurrel, S. J. Leach Immunochemistry 1977, 14, 565.
- ^ K. S. Lam, S. E. Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski, R. J. Knapp Nature 1991, 354, 82; and its correction: K. S. Lam, S. E. Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski, R. J. Knapp Nature 1992, 360, 768.
- ^ S. J. Taylor, J. P. Morken Science 1998, 280, 267.
- ^ J. Nielsen, S. Brenner, K. D. Janda J. Am. Chem. Soc. 1993, 115, 9812.
- ^ V. Nikolaiev, A. Stierandova, V. Krchnak, B. Seligman, K. S. Lam, S. E. Salmon, M. Lebl Pept. Res. 1993, 6, 161.
- ^ S. Brenner and R. A. Lerner Proc. Natl. Acad. Sci. USA 1992, 89, 5381.
- ^ J. Nielsen, S. Brenner, K. D. Janda J. Am. Chem. Soc. 1993, 115, 9812.
- ^ M. H. J. Ohlmeyer, R. N. Swanson, L. W. Dillard, J. C. Reader, G. Asouline, R. Kobayashi, M. Wigler, W. C. Still Proc. Natl. Acad. Sci. USA 1993, 90, 10922.
- ^ X. -D. Xiang et al. "A Combinatorial Approach to Materials Discovery" Science 268 (1995) 1738
- ^ J.J. Hanak, J. Mater. Sci, 1970, 5, 964-971
- ^ Combinatorial methods for development of sensing materials, Springer, 2009. ISBN 978-0-387-73712-6
- ^ V. M. Mirsky, V. Kulikov, Q. Hao, O. S. Wolfbeis. Multiparameter High Throughput Characterization of Combinatorial Chemical Microarrays of Chemosensitive Polymers. Macromolec. Rap. Comm., 2004, 25, 253-258
- ^ H. Koinuma et al. "Combinatorial solid state materials science and technology" Sci. Technol. Adv. Mater. 1 (2000) 1 free download
- ^ Andrei Ionut Mardare et al. "Combinatorial solid state materials science and technology" Sci. Technol. Adv. Mater. 9 (2008) 035009 free download
- ^ Applied Catalysis A, Volume 254, Issue 1, Pages 1-170 (10 November 2003)
- ^ , J. N. Cawse et. al, Progress in Organic Coatings, Volume 47, Issue 2, August 2003, Pages 128-135
- ^ Combinatorial Methods for High-Throughput Materials Science, MRS Proceedings Volume 1024E, Fall 2007
- ^ Combinatorial and Artificial Intelligence Methods in Materials Science II, MRS Proceedings Volume 804, Fall 2004
- ^ QSAR and Combinatorial Science, 24, Number 1 (February 2005)
- ^ J. N. Cawse, Ed., Experimental Design for Combinatorial and High Throughput Materials Development, John Wiley and Sons, 2002.
- ^ D. Newman and G. Cragg "Natural Products as Sources of New Drugs over the Last 25 Years" J Nat Prod 70 (2007) 461
- ^ M. Feher and J. M. Schmidt "Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry" J. Chem. Inf. Comput. Sci., 43 (2003) 218
- ^ M. Feher and J. M. Schmidt "Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry" J. Chem. Inf. Comput. Sci., 43 (2003) 218
- ^ Su QB, Beeler AB, Lobkovsky E, Porco JA, Panek JS "Stereochemical diversity through cyclodimerization: Synthesis of polyketide-like macrodiolides." Org Lett 2003, 5:2149-2152.
External links[edit]
- English version of the 1982 document
- "The concealed side of the history of combinatorial chemistry"
- IUPAC's "Glossary of Terms Used in Combinatorial Chemistry"
- ACS Combinatorial Science (formerly Journal of Combinatorial Chemistry)
- Combinatorial Chemistry Review
- Molecular Diversity
- Combinatorial Chemistry and High Throughput Screening
- Combinatorial Chemistry: an Online Journal
- SmiLib - A free open-source software for combinatorial library enumeration
- GLARE - A free open-source software for combinatorial library design


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97 F3d 1457 Perrymore v. Cooper Communities Inc
97 F.3d 1457
Russell PERRYMORE, Appellant,
COOPER COMMUNITIES, INC., Appellee.
No. 96-1258.
United States Court of Appeals, Eighth Circuit.
Submitted Sept. 10, 1996.
Decided Oct. 1, 1996.
NOTICE: Eighth Circuit Rule 28A(k) governs citation of unpublished opinions and provides that they are not precedent and generally should not be cited unless relevant to establishing the doctrines of res judicata, collateral estoppel, the law of the case, or if the opinion has persuasive value on a material issue and no published opinion would serve as well.
Before MAGILL, FLOYD R. GIBSON, and MORRIS SHEPPARD ARNOLD, Circuit Judges.
Russell Perrymore appeals the grant of summary judgment to Cooper Communities, Inc., in a case involving alleged wrongful discharge, age discrimination, and outrage. We have read all of the materials submitted by the parties and have considered their arguments. We see no error by the district court1 and therefore affirm the judgment. See 8th Cir. R. 47B.
The Honorable Jimm Larry Hendren, United States District Judge for the Western District of Arkansas


text:
Christina Aguilera Biography
Christina Maria Aguilera, 18 December 1980, Staten Island, New York, USA. Aguilera was one of several US teen pop stars to rise to huge popular acclaim in the late 90s. Of Irish and Ecuadorian descent, her mother played violin and piano professionally while her fathers position in the military resulted in the family travelling extensively around the world. Finally settling in Wexford, Pittsburgh, Aguilera began performing at school talent shows, before making her first professional appearance at the age of eight on the nationally syndicated Star Search show. When she was 10 she sang the national anthem for the Pittsburgh Steelers and Pirates. She joined [ Walt ] Disneys Mickey Mouse Club at the age of 12, appearing alongside future pop stars JC Chasez and Justin Timberlake of *NSYNC, and Britney Spears. Aguilera spent two years with the Mickey Mouse Club before moving to Japan to record All I Wanna Do, a hit duet with local pop star Keizo Nakanishi.
Back in the USA in early 1998, Aguilera recorded Reflection for the soundtrack of Disneys full-length animation Mulan. Her rapid ascent to stardom continued when she signed to RCA Records shortly afterwards. Her debut album was recorded with a host of leading songwriters and producers. Genie In A Bottle, a lightweight urban pop number with an infectious hookline, went to the top of the US charts in July 1999. Written by UK-based songwriter Pam Sheyne, the single stayed at the top for five weeks, making it the biggest selling US single of the year. The other tracks on Aguileras self-titled debut included upbeat dance anthem Love Will Find A Way, soulful ballad So Emotional, and the requisite Diane Warren blockbuster, I Turn To You. The album entered the US album chart at number 1 in September. A month later Genie In A Bottle entered the UK singles chart at number 1. Aguilera proved herself a genuine rival for Spears teen pop crown when she returned to the top of the US charts in January 2000 with What A Girl Wants and again in October with Come On Over Baby (All I Want Is You). In a shrewd marketing ploy, she then released a Spanish-language collection of her hits, Mi Reflejo, and the seasonal My Kind Of Christmas. The singer enjoyed a transatlantic chart-topper the following summer with a cover version of LaBelles Lady Marmalade, recorded with Lil Kim, Mya and Pink for the soundtrack of the movie Moulin Rouge.
Aguilera unveiled a new sexually-charged image on her second studio album, 2002s Stripped. The set was initially a commercial flop on both sides of the Atlantic, although it picked up momentum in the UK when Aguilera enjoyed surprise chart-toppers with the singles Dirrty (featuring Redman) and Beautiful (written by Linda Perry of 4 Non Blondes fame). The latter also broke into the US Top 5 and helped push Stripped back up the charts. Further transatlantic hit singles from the album included Fighter, Cant Hold Us Down and The Voice Within, while Beautiful picked up a Grammy Award for Best Female Pop Vocal Performance.
Aguilera was involved with two popular singles in 2004. The first, a remake of the Rose Royce disco classic Car Wash, was recorded with rapper Missy Elliott for the Shark Tale soundtrack. The second saw her collaborating with Nelly on the salacious Tilt Ya Head Back. Aguilera married music executive Jordan Bratman on 19 November 2005. Her lengthy absence from the charts in a solo capacity was broken in summer 2006 when Aint No Other Man climbed into the US Top 10. The attendant Back To Basics was the singers first US chart-topper since her 1999 debut. Inspired throughout by traditional jazz and blues, this deliriously fun double album featured one disc of modern, beat-driven material and another recorded live on analogue equipment.
Source: The Encyclopedia of Popular Music by Colin Larkin. Licensed from Muze.


text: Arts Notes: Dec. 29, 2013 By Staff reports December 28, 2013 Story Share Closing at Clay CenterCHARLESTON, W.Va. -- The "Trees of the World" exhibit will close at the Clay Center for the Arts and Sciences of West Virginia Dec. 31. Decorated by area students, this exhibit features trees reflecting holiday traditions from countries around the globe.The "Reason for the Season" planetarium show will continue through Epiphany on Jan. 6. Viewers are encouraged to gaze up at the winter sky and let the stars and constellations reveal stories of the world's many holiday traditions. Shows are at noon and 2 p.m. Sunday and 11 a.m. and 2 p.m. Wednesday through Saturday.Holiday break activities continue for school-age children. On Dec. 29 from noon to 4 p.m., children can do crafts related to the Netherlands. They will make Dutch pottery paper plates. On Dec. 30, they create a craft related to China: snake pencil toppers. Activities are free with gallery admission."Dinosaurs: Giants of Patagonia" and "Sea Monsters: A Prehistoric Adventure" are the giant-screen films showing through Jan. 4. "Dinosaurs" can be viewed 1 and 4 p.m. Wednesday through Sunday. "Sea Monsters" can be viewed noon and 3 p.m. Wednesday through Saturday and 3 p.m. Sunday.Ethan Murrow's "Positions of Power, Land View" exhibit will close Jan. 5. Visitors examine land, places and people from an aerial perspective in this exhibit featuring graphite and wall drawings, installation and video.Clay Center for the Arts and Sciences of West Virginia, 10 a.m. to 5 p.m. Wednesday through Saturday, noon to 5 p.m. Sunday, One Clay Square, Charleston; www.theclaycenter.org, 304-561-3570. The Clay Center will be open special holiday hours. In addition to the regular hours, they will be open 10 a.m. to 5 p.m. Dec. 30 and 10 a.m. to 3 p.m. Dec. 31. A Smart Pass (includes galleries, film and planetarium) costs $14.50 for adults and $12 for children, teachers and senior citizens; galleries only cost $7.50 for adults and $6 for children, teachers and seniors. Members get free, unlimited access to galleries and planetarium shows, as well as discounts on films.Jewelry workshopsCHARLESTON, W.Va. -- Kymberly's Kreations will begin jewelry-making workshops Jan. 6. Participants can enjoy wine and snacks while putting together their own beaded jewelry creations under the guidance of Kymberly Young, owner of the shop. Designers select their beads and spacers from a large variety to create their own jewelry. At 5:45 p.m. every Monday, an alcohol-free jewelry design class is offered with soft drinks, bottled water and snacks. "Design & Wine" will begin at 5:45 p.m. every Tuesday and Thursday. At 2 p.m. on Saturdays, beaded jewelry classes are offered for children and adults. Saturday classes can be incorporated into birthday parties.Classes cost $45 per adult and $35 per child. Participants using their own supplies can attend for $25 per session.To register for the classes, call Young at 304-437-1069. Proceeds from the classes help animal rescue efforts. Participants are encouraged to bring donations of dog and cat food and cat litter to assist rescue animals.Kymberly's Kreations, Suite 100, Medical Arts Building, 1021 Quarrier St.Gallery staff honoredHUNTINGTON, W.Va. -- Renaissance Art Gallery director Fern Christian was honored with Tri-State Artists Association's Community Service award at their 2013 Christmas dinner. Kathy Hollet also was honored. Both have served on the TSAA board of directors, served as president, and have spent thousands of hours on committees to support TSAA's mission and its membership. They are the first recipients of the association's community service award. Recipients of the award must have a minimum of 10 years of uninterrupted membership and community service in the association to be eligible for the award.Christian is the founder and director of the Renaissance Art Gallery, an artist-cooperative gallery, where she teaches painting on Monday mornings. Hollet has mentored new members, taught art classes, and wrote grants for the TSAA.Renaissance Art Gallery, 900 Eighth St., Suite 20, Huntington. 304-525-3235 or 304-453-3187 or firstname.lastname@example.com; www.orgsites.com/wv/renaissance; http://renaissancegalleryart.blogspot.com. Gallery hours are noon to 4 p.m. Friday and Saturday, 1 to 4 p.m. Sunday. Studio hours 10 a.m. to noon Monday, 1 to 7:30 p.m. Wednesday and 10 a.m. to noon Saturday.To have your announcement included in Arts Notes, email firstname.lastname@example.com or send it to Arts Notes, The Charleston Gazette, 1001 Virginia St. E., Charleston, WV 25301. Artwork can be submitted electronically or by mail. Deadline for inclusion in the Sunday Gazette-Mail is the Tuesday before Sunday publication. Story Share Story Share Trending Now 1 WV Gov. Justice discharged from Johns Hopkins Hospital after two-day stay 2 'Snubbed' Kyle Bosch trying to get WVU o-line right 3 Kanawha magistrate facing judicial misconduct charges 4 PHOTOS: Girls Night Out in Charleston 5 WR Jovon Durante leaving WVU for FAU Live Life Fully: Glass half empty? Fill it Previous Story Book Notes: Dec. 29, 2013 Next Story


text:
Sewickley library exhibit celebrates the child inside grown men
John Stupp got his first car when he was a child in the 1950s.
Today, he has many more that he keeps in his basement, although some now are displayed in Sewickley Public Library's latest exhibit, "The Toys of Grown-Up Boys," which runs through June 30.
Stupp of Sewickley, whose wife Betty Stupp is the children's clerk at the library, has contributed his collection of miniature model cars, replicas of vehicles driven at the Targa Florio, an Italian auto race, in the 1950s, 1960s and 1970s, to the exhibit.
His "toys" are one of six collections displayed at the library during regular library hours.
His miniature vehicles, called slot cars, come in several sizes, are powered by an electric motor and can be driven around a track that has a slot cut into it.
A guide pin or blade holds the car in place while it runs, and a hand-held controller increases or decreases speed.
Stupp's display also features photos and posters of the real Targa Florio, which began in 1906 in Sicily, and pictures of Stupp's own basement replica of the racetrack, which took a year to plan and build.
"Italians have a long history of racing between towns on the same roads used for local traffic, and the Targa was the last Italian sports-car road race of this type," he said
"The historical pictures of the Targa from its earliest days, up to its conclusion, with villagers crowded on every roadside in the mountains and with narrow village streets winding through picturesque Italian towns — this inspired me to build a race course complete with towns, people and scenery."
Part of the track is elevated in the "mountains," and the other part runs down into a valley, around a lake and through a village that is modeled after the real Sicilian village of Collesano, near Palermo.
Stupp said he has been interested in racing since he was a boy growing up in Cleveland following the sports car racing rivalries among Ferrari, Alfa-Romeo, Jaguar, Corvette, Porsche, Ford Cobra and Ford GT-40s.
He remembers the famous drivers of the era in the pages of Sports Car Graphic and Road & Track Magazine.
His slot-car collection began with an Aurora HO car set that ran alongside an HO train set that he got for Christmas one year. A few years later, he also received a Strombecker racing set.
Also showing off his "toys" is Jim Wiltman, of Sewickley Heights, who will have some of his collection of bobbleheads, which at one time numbered about 300.
After giving some away, he said, he still has about 50, many of Hall of Fame players.
The collection began about 15 years ago when he and his children, Stephanie, 21; Von, 19; and Fritz, 15, regularly attended Pittsburgh Pirates and Pittsburgh Penguins games together.
At that time, he said, only certain bobbleheads were given out at the games to recognize noteworthy players, but, now, they are given as more of a promotional item of current players, some wearing different types of jerseys.
The one bobblehead he said he will never give away is of former Pittsburgh Pirate and Baseball Hall of Fame player Roberto Clemente.
He also kept his first one of Pirates Hall of Fame second baseman Bill Mazeroski, along with one of Hall of Fame player Willie Stargell and more recent Pirate players Jason Bay and Freddy Sanchez.
Also in his collection is a Mark Recchi bobblehead that came out the day before the Penguins traded him in 2006. Wiltman said he was told the Penguins held off trading him until they were able to give away his bobblehead.
He said he and his children still go to the games and collect the bobbleheads. They give some of the duplicates away.
Others displaying their toy collections at the library are Norm Voigt of Pittsburgh, husband of librarian Mary Jean Voigt, trolleys and buses; Bobby Linn of Dormont, Star Wars figures and spaceships; John Gardner of Denver, father of librarian Meghan Snatchko, train engines and cars; and Howard Stuber of Rochester, firetrucks.
Joanne Barron is a staff writer for Trib Total Media. She can be reached at 412-324-1406 or firstname.lastname@example.com.


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Pastor Cheryl Roshon of Polk United Methodist Church writes about keeping love and Jesus at the fore
Current subscribers have full access to all online news content as part of their subscription. If you are a current subscriber, please log in with your website account information for full access. If you are a current subscriber, but have not yet registered for access to the website, please call our Circulation Department at (419)281-0581


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Hi all.I have a wordpress blog which is hosted on there servers.Like xxx.wordpress.com.And I want to show my old as well as new posts to this blog.Due to i am not hosting the blog,I cant use plugins.So when I came to know about rss graffity app,I added it to my page and nothing happened.Means there are no posts on my timeline.Can anyone tell where I am going wrong?Or what is the procedure of adding this app?Please help me.
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LG Optimus Me P350 User Reviews
Overal user rating
The overall rating is the average of all user reviews, while the overall alternatives are the ones that has been listed most.
Camera4/10Multimedia6/10Internet7/10Call quality6/10Battery6/10Reception4/10Display5/10Build quality7/10Text input4/10Everyday usage2/10UI speed2/10
Post new review
Please note that each user review reflects the opinion of its respectful author and not of Phone Arena.
posted on 30 Oct 2012, 03:39 (Posts: 0; Member since: 30 Oct 2012)
LG Optimus Me
jeykumar has owned it for less than year before publishing this review
"A Budget Smart Phone"
i have been using this smartphone about 4 months...a decent phone..
I rooted the phone installed custom rom..now the phone is really fast..supports some apps..
not suitable for playing games..Build quality 7/10Reception 4/10Call quality 6/10Internet 7/10Multimedia 6/10Camera 4/10UI speed 2/10Everyday usage 2/10Text input 4/10Display 5/10Battery 6/10
- Budget Smart Phone
- Pocket Friendly
- Good Batterylife
- Durable
- Low Processor
- Lags
- Poor Camera
- No Flash, auto focus
2 out of 2 people found this review helpful. Do you?Report
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In addition to Mark's crazy drunken stories about being in a high-speed chase we get to hear Michelle Smoller's Movie Minute! where she interviews movie goers outside the Magic Johnson theatre in Harlem about Expendables 2. Oh it's not going to be awkward at all!
Heavy is proud to be the home of 'My Dumb Friends' with Sean Donnelly and Dan St. Germain. Check back for new episodes every Thursday!
Here is a video of Mark on Comedy Central!


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These gluten free chocolate cookies are based on my gluten-free chocolate chip cookies, and are just as good. Crisp on the outside, chewy on the inside, with the added bonus of a deeply chocolaty flavor. My husband and I prefer the original version, the kids prefer this version – which will you like better? I bet you're curious to know. :)
Gluten Free Chocolate Cookies
Prep and Cool time
Cook time
Total time
Author: Vered DeLeeuw
Recipe type: Dessert, Gluten-Free, Low-Carb
Yield: 15 cookies
- 6 tablespoons unsalted butter, soft
- ½ cup sugar
- ¼ cup unsweetened cocoa powder
- 1 teaspoon pure vanilla extract
- 1 large egg
- ¼ teaspoon baking soda
- ¼ teaspoon kosher salt
- 1¼ cups almond meal/flour
- ½ cup (84 grams) dark chocolate chips (60% cacao)
- Preheat oven to 350 degrees F. Line two cookie sheets with parchment paper.
- Using a handheld electric mixer, beat together the butter and sugar until creamy. Add the vanilla and the egg, mixing to incorporate, then mix in the cocoa, the baking soda and the salt.
- Gradually mix in the almond meal, ⅓ at a time, until well-blended.
- Using a spatula, fold in the chocolate chips.
- Drop dough by rounded tablespoonfuls (I used a 2-tablespoons ice cream scoop), three inches apart, onto the prepared baking sheets. Do not flatten.
- Refrigerate 30 minutes – this will help prevent the cookies from spreading too much as they bake.
- Bake 20 minutes. Allow to cool completely on the baking sheets, about 30 minutes. This will help achieve a crispy exterior and a chewy interior.
Nutrition Per Serving
Serving size: 1 cookie; Calories: 158; Fat: 12g; Carbohydrates: 12g; Sugar: 9g; Sodium: 48mg; Fiber: 2g; Protein: 3g


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|Federal Information & News Dispatch, Inc.
Chairman Ryan, Representative
I would like to begin by saying a little about the role of the
I am appearing before your Committee today in my role as an independent technical advisor to
In view of your Committee's interest in budgetary impacts, and the
I would also like to caution the Committee about the uncertainty of financial projections for health insurance programs. Certain aspects of projections, such as the demographic characteristics of the population, are relatively predictable. n1 Projections of health cost trends, however, are much more uncertain and depend critically on future economic developments, advances in medical technology, and other factors.
It is helpful to consider
Health spending in the U.S. has generally increased at a significantly faster pace than the economy, rising from 5.2 percent of GDP in 1960 to 17.9 percent in 2010. The upward trend has fluctuated somewhat, depending on the business cycle (which affects GDP growth) and on faster or slower periods of health cost growth. For example, national health expenditures represented about 13.8 percent of GDP for much of the 1990s, reflecting stronger-than-average real economic growth during much of this period and the widespread adoption of managed care health plans. Conversely, the share of GDP devoted to health care accelerated sharply in the early 2000s in part as a result of the public backlash against health care utilization controls and the economic recession that began in 2001.
From their enactment in 1965,
Chart 2 shows the proportion of total U.S. health expenditures by source of payment for 1976 compared to 2010. n2
Chart 2--Distribution of national health expenditures by source of payment, 1976 and 2010
Source of payment 1976 2010
Individual's out-of-pocket costs 27% 12%
Private health insurance 24% 33%
Veterans Admin.,
Other third-party payers and programs 11% 7%
Public health 2% 3%
Investment 9% 6%
* The
* Expenditures by private health insurance plans grew at a somewhat slower rate as a result of the widespread adoption of managed care plans, including health maintenance organizations and preferred provider organizations. In addition, many employers sought to reduce cost growth by taking advantage of competition among insurers and through more frequent adjustments in employee cost-sharing requirements. Also, the proportion of the population with employer-sponsored insurance has declined over time.
* Contrary to popular conceptions, the aging of the post-World War II "baby boom" generation did not have a large impact on the increase in
Chart 3 helps to explain why health care costs tend to increase at a faster rate than the overall economy. As indicated, health care cost growth averaged 9.6 percent per year from 1965 to 2010. About 1.0 percentage point is attributable to the growing population (more people, more health expenditures, all else equal). General, economy-wide inflation contributes to higher medical prices, adding about 4.0 percentage points on average over this period.
In addition, medical prices tend to grow at a somewhat faster pace than general economic inflation, since (i) a greater proportion of health care is produced by human capital than in the economy at large, and (ii) productivity improvement is lower for health care providers, reflecting their higher labor share and the individualized nature of many health services. Together, these factors have increased medical prices by about 1.4 percent annually above the level of economy-wide price growth, as measured by the GDP implicit price deflator.
Over time, people tend to use more health care services, and the services tend to be more complex and expensive as new technology is developed. The "volume and intensity" of services per person has added about 2.9 percentage points per year to personal health care expenditure growth. Together, the increases in population, general prices, excess medical-specific prices, and volume and intensity, plus a small contribution from changes in the age and gender distribution of the population, have resulted in an overall average growth rate for personal health care expenditures of 9.6 percent over the last 45 years.
Similarly, growth in the economy can be decomposed into several roughly corresponding factors. The first of these is the increase in the number of workers, which has averaged 1.7 percent during 1965 to 2010--aided in part by the entry of the baby boom generation into the labor force.
The impact of general economic inflation, at 4.0 percent, is the same for both health expenditures and nominal economic growth. The increase in real (inflation-adjusted) GDP per worker occurs primarily as a result of productivity gains and has averaged 1.2 percent over this period.
Collectively, these economic growth factors add up to 6.9 percent, which has been well below the 9.6-percent growth in health expenditures. (As suggested by the trend variations shown in chart 1, the differential between health cost growth and economic growth has not been constant over time.) Going forward, employment growth is likely to be somewhat slower than overall population growth as the baby boom generation leaves the work force. The effect of general inflation is the same for both categories, but, based on past trends, labor productivity growth isunlikely to keep pace with continuing increases in excess medical prices plus the volume and intensity of services per person.
Another way to assess the causes of rapid health care expenditure growth is through an economic analysis of the key factors leading to increased demand for services and higher costs. Chart 4 summarizes the most recent research in this area, as published by
Factor Contribution to growth (percent)
Income effects 28-41
Relative medical price inflation 8-21
Demographic effects 7
Change in insurance coverage 10
Technology 26-45
Income growth has long been identified as a primary contributor to higher health spending. As individuals, or nations, become "richer," they tend to spend an increasing amount on health care. Smith et al. estimate that real per capita income growth during 1960 to 2010 was responsible for between 28 and 41 percent of the increase in real per capita health expenditures.
Relative medical price inflation (above and beyond economy-wide inflation) was found to have contributed between 8 and 21 percent. Demographic effects were not substantial over this period, but they explain about 7 percent of total health cost growth, while broader availability and higher levels of health insurance account for another 10 percent.
The impact of technology on health cost growth is usually measured as the residual, after all of the factors above have been estimated. In the Smith et al. analysis, technology is estimated to account for between 26 and 45 percent of historical real health expenditure growth per person. (In practice, other factors that are not separately estimated will also be included in the residual category. Such factors are believed to have only a small effect.) Technological advances contribute to expenditure growth both through the adoption of new treatments, devices, and drugs, such as implantable defibrillators, and through the ability of the health sector to apply existing services to a broader group of people, for example heart bypass and hip replacement operations to older patients. Although some new technologies enable the provision of existing services at lower costs, historically most technology has been cost-increasing. Growing incomes and the widespread availability of health insurance facilitate a ready market for new developments, even if their cost is much higher than existing treatments.
As the Trustees and I have cautioned, it is important to note that the actual future costs for
The primary sources of financing for the
* Payroll taxes--Part A of
* Income taxes on
* Beneficiary premiums--Parts B and D of
* Payments by States--With the transfer of prescription drug costs for dual Medicare-Medicaid beneficiaries to Part D of
* Fees on prescription drugs--Starting in 2011, manufacturers and importers of brand-name prescription drugs are required to pay annual fees, with the payments credited to the Part B trust fund account. These payments reduce the premiums and general revenues otherwise required to finance Part B.
* Federal general revenues--Roughly three-fourths of Part B and Part D costs are met by the general fund of the Treasury. As with beneficiary premiums, general revenues for these programs are reset annually and increase at the same rate as program expenditures. Consequently, income for Parts B and D automatically matches expenditures without the need for legislative adjustments. As a result of this financing basis, and the slowdown in payroll tax receipts due to the 2008-2009 recession, general revenues recently became the largest source of
* Interest--Any
In the early years of
Chart 6 shows past and projected
Expenditures are projected to increase as a share of GDP thereafter, but at a slower rate than historically as noted previously.
Together, the SGR formula and the reduced payment updates under the Affordable Care Act are estimated to permanently reduce
The first approach is to simply reduce payments to providers--hospitals, doctors, and pharmaceutical companies. This blunt strategy can work, often quite well, in the short run. It is inherently limited over the medium and long term, however, unless accompanied by other measures to reduce the underlying quantity of services provided. If only
If the SGR provision continued to be overridden and the productivity adjustments to other provider payment updates became unworkable, then future
Chart 7 shows the long-range projection of
In 2010, total
For comparison, costs under the illustrative alternative projections increase rapidly throughout the long-range period, reaching 10.7 percent of taxable payroll in 2085, compared to 6.2 percent under current law. Thus, depending on the long-range feasibility of the SGR provision and the slower payment updates for other providers,
It is possible that providers can improve their productivity, reduce wasteful expenditures, and take other steps to keep their cost growth within the bounds imposed by the
The effect of the baby boom generation on
Historically, total (Federal plus State) expenditures on behalf of
Chart 9 shows Federal, State, and total
Chart 9--
Medical assistance payments (MAP):
Acute care benefits2
Long-term care benefits2 76.3 36.7 113.0
Capitation payments2 71.5 32.4 103.9
DSH payments2 8.7 6.5 15.2
Adjustments3 4.7 3.6 8.3
Subtotal MAP 259.7 123.4 383.1
Administration payments 10.1 8.0 18.1
Vaccines For Children program 3.8 0.0 3.8
Gross outlays 273.5 131.4 404.9
Collections -0.8 -0.1 -0.9
Net outlays 272.8 131.3 404.1
Chart 10 presents the distribution of
As indicated in chart 11,
States have taken many steps in recent years to try to reduce
Chart 12 shows projected
My final graph (chart 13) illustrates the level of national health expenditures as a percentage of GDP under several hypothetical cost growth rates in the long-range future. On average during 1960 through 2010, per capita health care spending increased at the rate of growth in per capita GDP plus another 2.6 percentage points. If that long-range past trend continued in the long-range future, national health expenditures would represent more than 100 percent of GDP--an obviously impossible situation. The pursuit of better health will continue to be extremely important, but it cannot crowd out food, clothing, housing, and all other necessities and desires of life.
Over the last 20 years, health spending has increased at the rate of GDP plus 1.9 percent. Even if this rate continued into the indefinite future, health care would represent an untenable proportion of total economic production. As the late economist
Most people would agree that certain developments, which could reduce the rate of health spending growth, would be very undesirable. For example, if individuals' premiums and cost-sharing liabilities were to increase significantly faster than their incomes for a sustained period, then many might find these costs unaffordable and have to drop out of their insurance plans and forgo needed services. Health expenditure growth would slow--but only because an increasing amount of appropriate care would be forgone. A similar situation could occur if employers continue to face cost increases for their group health insurance plans that outstrip their revenue increases, forcing them to scale back or drop their employee coverage to remain financially viable. Alternatively, if payment rates to health care providers were reduced or slowed too much, as may have already occurred for some State Medicaid plans and as may be the case in the future for
Many ideas have been developed and tried over the years in an effort to reduce health care cost growth. Examples include the development of prospective payment systems and other bundled-payment mechanisms; the widespread adoption of managed care plans; efforts to facilitate more prudent use of health care services through consumer-driven health plans and medical savings accounts; use of "lean production" techniques by hospitals and other facilities; and, most recently, the development of accountable care organizations, medical homes, disease management, and other efforts to better integrate the delivery of care. Most of these efforts have had some positive impact on lowering the level of health care costs, but there is relatively little evidence that they have succeeded in reducing cost growth rates.
As indicated by the Smith, New house, and Freeland analysis of the causal factors underlying health care cost growth, the two largest contributors have been rising incomes and new medical technology. It is not surprising that increasing incomes prompt both individuals and nations alike to seek better health care. This trend could persist for many years, although demand for continually more and better health care services would presumably slow if meeting that demand could be accomplished only by reduced consumption of other necessities or high-priority goods and services.
The development and adoption of new medical technology may prove to be pivotal in future efforts to slow health care cost growth. Numerous studies have found that most new health technology has been cost-increasing, encouraged by comprehensive insurance coverage that shields individuals from most of the additional direct costs of using the new technology. Over time, as all payers continue to seek ways to reduce costs and as providers can no longer be assured of revenue flows that will automatically adjust to their higher cost levels, the medical research and development community may direct their efforts more toward new treatments, devices, and drugs that can provide health outcomes that are equal to or better than those provided by existing technology but at a lower cost.
Signs of such a change in focus are already apparent. For example, efforts are underway to produce a one-time-use implantable defibrillator, which would be just as effective in an emergency as the existing multiple-use devices but would cost far less. In overseas health markets, most developing nations cannot afford the expensive health technology produced in the U.S., and a market is developing for somewhat less effective--but far less expensive-- technology, such as fewer-slice / lower-field-strength MRI machines. As this market grows, U.S. providers, payers, and developers may join in.
A related area of policy consideration is "comparative effectiveness research." While controversial, the potential benefits of these efforts are significant. There have been many examples of new drugs and devices that have offered only a limited improvement (if any) over existing treatments but that cost substantially more. The introduction of the proton pump inhibitor drug Nexium, when the nearly identical drug Prilosec was about to lose patent protection, is a well-known example. n13 It is reasonable to expect that science can be applied to assess whether a new technology's minor gains justify what might be a major increase in expenditure.
Finally, public and private efforts to research alternative health care delivery systems and payment methods could lead to innovative new approaches with the ability to improve the quality of care and/or reduce the cost of care. The program authorized by the Affordable Care Act, through the new
Thank you for this opportunity to meet with your Committee. I applaud your efforts to strengthen
n1 For example, in 1957 noted actuary and demographer
n2 The National Health Expenditure accounts also track health care spending by type of service (such as hospital care, physician services, and prescription drugs) and by source of financing (governments, businesses, and households). The historical and projected NHE accounts are available at http://www.cms.gov/NationalHealthExpendData/01_Overview.asp .
n4 For hospitals, skilled nursing facilities, home health agencies, diagnostic laboratories, and most other providers of health services,
n5 Federal Insurance Contributions Act and Self-Employment Contributions Act, respectively.
n6 The Affordable Care Act also specifies that individuals with incomes greater than
n7 These projections are drawn from the 2011 Medicare Trustees Report and thus do not reflect the Budget Control Act of 2011, the Temporary Payroll Tax Cut Continuation Act of 2011, or the Middle Class Tax Relief and Job Creation Act of 2012. The forthcoming 2012 Trustees Report will incorporate these impacts.
n8 Orszag, Peter R., "How Health Care Can Save or Sink America," Foreign Affairs Vol. 90, No. 4, July/
n9 As described in my
n10 To help illustrate the degree to which the current-law projections potentially understate actual future costs, the
n11 The forthcoming 2011 Actuarial Report on the Financial Outlook for
n12 "National Health Spending Projections Through 2020: Economic Recovery and Reform Drive Faster Spending Growth," Health Affairs Vol. 30, No 8 (2011). http://www.cms.gov/NationalHealthExpendData/01_Overview.asp .
n13 See, for example, Dr.
Read this original document at: http://budget.house.gov/UploadedFiles/FosterTestimony_2-28-22012.pdf
|(c) 2010 Federal Information & News Dispatch, Inc.


text:
Sold Out
lightweight cotton jumpsuit in natural with soft elastic waist. shoulder ties allow you to adjust the length. please note. sizes run small, we suggest that you go up a size.
also available in white, navy, and blue & white stripe
size and fit
Sizes are indicated in years so when selecting sizes, choose the size closest to your babys age.
Please contact us if you have any questions about the sizing of this product.
garment care
100% pure cotton gauze. cold gentle machine wash. air dry.
we dye the fabrics of our carriers and accessories using only plants & herbs. Due to this, in some instances, the lack of chemicals can result in small colour runs, or fading in areas where the natural mordant may not have taken to the fabric.
Please take care when washing and use an organic or gentle environmentally friendly detergent.


text:
- Sound: 8
- Overall Impression: 8
- Reliability & Durability: 7
- Action, Fit & Finish: 6
- Features: 8
Users' score:
(2 votes)
Price paid: C$ 350
Purchased from: Local Music Store
Sound — 8
I play mostly prog, classic rock and a bit of alternative. This bass is better suited to the last two, but it's very versitile. The part that makes it great is that one pick-up plays the treble end and the other carries the low end. So there are several tones that can be made by tweaking the volume on both of them. Also being a hollow-body, it can fake an upright fairly well and play softer styles like folk. The only flaw in this area is that because of the short neck scale, the lowest string doesn't sound as good as the other three.
Overall Impression — 8
This is a great bass for a good price, (At least where I got it). The shorter scale also means that if it's your first bass (it is my fisrt) there isn't too much of a strain compared to a 34'' scale neck. However, as I've progressed, having a short scale neck becomes a problem for feel and a low end tone. Still a great bass for beginners.
Reliability & Durability — 7
I haven't played this bass too much live, but it has been fine for nearly 4 hours straight in practice. The hardware is great and can go on forever, and it probably will. Still, being a hollow-body I don't think it can take quite as much of a beating as a solid-body.
Action, Fit & Finish — 6
The set-up on the bass wasn't bad, the action was a little low. This only became a real problem when the strins shifted a bit, and then the low E string was buzzing against some of the higher frets. That's probably the only problem I've had with this bass.
Features — 8
This is the Jay Turser immitation of the Hofner "Beatle-bass". However, it's built nearly as well as the real thing. - Made in Indonesia, around 2004/05 - 22 frets, rosewood fretboard, 30'' scale - maple body (I think), maple set-in neck - 2 passive humbuckers - each pick-up has a volume knob and on/off switch - foating bridge As I said at the beginning, this is a Beatle-bass replica, but in my opinion it's almost as good as a Hofner, and better than the Epiphone version. I'll admit that part of the reason I got it was at the time, I REALLY liked The Beatles.


text:
John Nebeker Massey
b.30 Nov 1820 New Castle County, Delaware
d.14 Nov 1906 Monroe County, Iowa
Family tree▼
m. 30 Nov 1841
m. aft Jan 1896
Facts and Events
John N. Massey's parents moved from Delaware (probably by way of Ohio, where several Massey cousins later lived) to Fountain County, Indiana, before 1838. John, a surveyor by trade, was in Peoria, Illinois, during 1838-39, then returned to Fountain County. (This is from a tattered and undated news clipping, probably from an Albia, Iowa, newspaper.) John became acquainted with the family of David Rowles, married David's daughter, known in the family as "Rosella," in 1841, and accompanied his father-in-law in the migration to Monroe County, Iowa Territory, in 1844.
In the summer of 1845, John surveyed the plat of Albia (originally called Princeton), which became the seat of Monroe County in 1846. He was elected County Surveyor that fall. He was elected County Judge in 1855, but was declared ineligible as he also held the office of School-Fund Commissioner.S3
"Then came the long-beamed break-plow, . . . which every person who has passed the residence of John Massey, south of Albia, during the last twenty-five years, has noticed leaning against the front-yard fence. Some months ago the writer, in passing, had the pleasure of seeing Mr. Massey's son, Ressie, plowing with this relic of a past generation. He was scouring it along the right-of-way of the railroad by way of preparing it for farming purposes."S4
Land claims in Fountain County:S12
Monroe County, Iowa, 1850 census:S5
Monroe County, Iowa, 1856 State Census:S6
Monroe County, Iowa, 1860 census:S7
Monroe County, Iowa, 1870 census:S8
Monroe County, Iowa, 1880 census:S9
Monroe County, Iowa, 1895 State Census:S10


text:
Well, what do we have here? What could be the fabled iPad mini has surfaced on Chinese microblogging site Sina Weibo, SlashGear reports.
The photo is a little gloomy, putting it politely, and there's not much detail. But this rear shot could be the closest we've come yet to seeing the iPad mini.
The rear shell is completely solid, so if genuine, Apple's smaller tablet won't have a rear-facing camera. That shouldn't be too much of a hindrance, considering the Nexus 7 and Amazon Kindle Fire do fine without. And who's taking pictures using their iPad camera anyway? If you do this at gigs, just know people are pointing and giggling at you.
It's far from certain this shot is genuine. The person posting it has no history of leaking Apple gear. And it seems to have been shot in a well. But the logo looks like the real deal. And the finish seems to match that of its bigger brother.
Apple is rumoured to be announcing an iPad mini on 12 September, alongside the next iPhone. What's that? You thought Steve Jobs hated 7-inch tablets? Well so did everyone, until yesterday, when an email emerged from Apple's Eddie Cue on the subject. He said he'd broached the topic of a smaller iPad and Jobs had seemed "very receptive" to the idea.
Jobs was notorious for changing his mind, and often went public on topics to wrong-foot competitors. He slammed netbooks at the launch of the original iPad, shortly before Apple unveiled the MacBook Air, which many would say is Apple's version of a netbook.
The iPad mini is rumoured to have a 7 or 8-inch screen and is thought to be Apple's response to Google's Nexus 7. The Nexus 7 comes in at a bargainous £160, so here's hoping Apple can keep the cost down.
What would you like to see in an iPad mini? Let me know in the comments or on Facebook.


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In the last 90 days, 8 listings have been listed, which means new listings might be going fast. You'll want to be prepared to tour spaces as quick as possible. About 150% of the office spaces in the Evansville East Side are subleases, so you might be able to snag a great spot on a short term. There aren't many listings below 2,000 square feet on the market, so finding a space for a small business might be tough.
Even though the median size is 10,000 sqft, there are still 0 office spaces below 2,000 sqft. Most buildings in this region are approximately 1 stories. Most buildings in this region were built in 1974 and are Class B.
Not much of the real estate is used for commercial space, so it might be hard to find office space. Professional services is the dominant industry in this market. Commute by bike is the most popular way to get to work amongst Evansville East Side residents. Commuting around an hour a day is the norm for those who opt to reside in this part of town.
Trends and status of the commercial real estate market in Evansville East Side.
Market Report
Real time and historical data on commercial real estate listings in Evansville East Side.


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BP Comment Quick Links
January 12, 2010
Expanded Horizons
Stories Big and Small
So oft in theologic wars,
The Goal
The goal of all baseball observers is to understand the game and its players in the richest way possible. For the sabermetrically inclined, the goal often means including fielding, baserunning, and the full picture of offensive value. Some carry out this search numerically, using WARP or WAR. Others seek knowledge through infographics. But the essential thread is comprehensivist.
The impulse to understand all aspects of player worth is not limited to those who hang their hats on processor cycles. The ink-stained wretches and beat writers, too, seek to gain full understanding, even if their methods can, at times, differ. Many of those who go to the ballpark every day claim it is the only way to grok all aspects of the game.
As the great philosopher Bill Waterson has noted, seeing a situation from all perspectives at once can be as paralyzing as it is informative. The task for those who follow the game must be to expand horizons up to the point beyond which one would lose the individual perspective that makes enjoyment of the game personal. In the journey to this balanced point of view, there can be no tools more valuable than curiosity and doubt.
The Big Unit and Looking Backward
Imagine Randy Johnson as the elephant in the parable of the "The Blind Men and the Elephant," most familiar from John Godfrey Saxe's poem of the same name. In it, several blind men feel different parts of an elephant, gaining local knowledge but ignorant of the entire beast. For example, some who have encountered Johnson found him to be so unpleasant personally as to overshadow his on-field accomplishments. Our new editor-in-chief, John Perrotto, saw the intelligent and funny man behind the mullet. Henry Schulman of the San Francisco Chronicle eulogized Johnson's 22-year career by noting that his "sidearm delivery [�] made left-handed hitters find religion." But none of these views captures the entire story.
The numbers are too overwhelming to overlook: 4,875 strikeouts, 89.7 WARP3, 91.8 rWAR (12th all-time among pitchers), 303 wins, and five Cy Young Awards (including four in a row). Among left-handed pitchers, only Lefty Grove, Sandy Koufax, and Steve Carlton even deserve mention in the barstool debate over the greatest of all time. And yet, a yellowed box score or a quick SQL query can't tell the full story either. Fungoes used its version of fielding-independent game score (FIGS) to rank Johnson's best outings, and his 20-strikeout, no-walk, no-homer outing from May 8, 2001 scored an impressive 98, ahead of even his perfect game. It is here that I must differ with the DIPS ranking. I was sitting in the cheap seats, acting like a hooligan, for Johnson's perfect game. The PBP data from Retrosheet does a reasonable job conveying the dominance, but even the Project Scoresheet stringer had to add a heterodox bold line to the ninth inning data: "the last pitch was a 98 mph fastball." At 40 years old, Johnson became the oldest member of the perfect game club. It was the most physically dominant performance I have ever seen.
Johnson's legend, like all great frontier legends, began in the backwoods of the Wild West. Whispers among scouts of the gangly pitcher in Northern California dubbed "Ichabod Crane"-whose pants didn't quite fit but who struck out hundreds in a single high school season-spread quickly. He took his electrifying fastball south on the I-5 to the University of Southern California, where he continued to show promise despite walking 188 batters in 243
The two iconic moments of Johnson's career, never to be omitted from the annals of baseball lore, help telegraph his transformation from wild man to pitcher. During the 1993 All-Star Game, Johnson struck out John Kruk on four pitches. The first, a fastball a good two feet above Kruk's head, led Kruk to indicate for the camera his elevated heart rate. The next three pitches were: (1) a fastball over the plate at the knees (strike looking), (2) a sweeping slider over the plate (a 540-degree flailing swinging strike), and (3) another sweeping slider (same swing, same result). That season, Johnson struck out 308 batters and allowed only 185 hits for the Mariners, but he walked 99 batters and hit another 16.
Eight years later, during spring training with the Diamondbacks, Johnson ended the life of an innocent dove with a fastball that was officially ruled "no pitch" (tell that to the bird). But the collision was surely the hapless bird's fault; Johnson's control had reached enviable levels. That season, Johnson struck out 372 and walked just 71 in 249
I have no way of knowing what a blind man feeling Randy Johnson's hair would report.
Looking back on a career, it can be difficult to separate the legend from the stats, the person from the player, the anecdotes from the data. The answer, I think, is to consider it all. From any view, Randy Johnson was one of the most memorable players in the history of baseball.
Ryne Reynoso and the Organization Minor Leaguer
Looking forward on a minor leaguer's career can be even more difficult. The fog of war and anecdotes can be even hazier for players in the low minors. Gone are the days where players and teams advertised their availability in The Sporting News. Nowadays, team-specific bloggers rank hundreds of prospects, and video of even fringy players is disseminated through YouTube. How is one to keep up with the fire hose of information?
One way is to ask Kevin Goldstein, whose knowledge is encyclopedic and whose Rolodex runs deep. Another way is to read reports in local newspapers, that dying breed. With this two-pronged approach, I promise nothing less than complete disconnect. As an example, take Ryne Reynoso, Player of the Year of the Idaho Mountain Express. The hometown pitcher, who spent most of last season with the Mississippi Braves, posted a middling 148-127-59-89 line at Double-A in 2009. The Mountain Express, however, points to his "ebullience" and "gregarious nature." From reading this small-town report, we can also learn that Reynoso and his bullpen comrades dug a 14-foot hole while on the road.
Prospect experts will tell you Reynoso's best path to the major leagues is probably in the bullpen, as his low-90s heat dances dangerously in the upper half, and his secondary offerings are no better than average. But how, then, would you learn that Reynoso shares an apartment in Atlanta with Tommy Hanson and Kris Medlen? Or that he hit .311 with a .511 slugging percentage as a sophomore at Boston College?
The Future
In a world where the 3D blockbuster Avatar has raked in over a $1 billion worldwide, it is no surprise that the cutting edge in sports television is a 3D channel from ESPN. While it remains unclear exactly what to expect from 3D television (as Justin Peters reports), it is unquestionable that more data is available now than ever before. Blinkers fall on all eyes, and groupthink is an all-too-common trap, but if we remain vigilant, we can use this information to our advantage.
Recently, the Crawfish Boxes wondered what effect the web has had on fan scouting. While there is a lot of professionalism in scouting that cannot be captured simply by video and statistics, it is true that a certain amount of being there has been substituted for the overwhelming information available on the internet. The same holds for sabermetrics. With learning resources available on general statistics and probability (I favor Khan Academy) and specific primers on subjects like SQL databases (Colin Wyers leads the way here), sabermetrics has definitively entered the "please try this at home" category.
Question(s) of the Day
What are the most under-reported aspects of baseball coverage? What are the biggest blind spots of baseball writers (SABR-inclined and otherwise)? What online resources best help to remedy those blind spots?
14 comments have been left for this article.
BP Comment Quick Links
John Carter
Don't forget Warren Spahn. That's four of the great pitchers of all time - pretty good representation considering their proportion of the population - and that most batters bat right-handed.
Jan 12, 2010 09:56 AM
Yes, you are right I should have included Spahn. Not that this is particularly a knock against him (and of course he was a great pitcher), but much of Spahn's value came from his longevity more than his dominance. I'd take RJ's peak over Spahn's peak, for sure.
Jan 12, 2010 11:32 AM
Peter Hood
I do think you've missed one very salient fact. Spahn spent 3 years 1943-5,his age 22-24 period, fighting in WWII. Hard to know how much of an impact that had but it certainly cost him some MLB time.
Jan 12, 2010 17:22 PM
I think that's an important point, and certainly worth taking into consideration.
Jan 12, 2010 19:48 PM
Richard Bergstrom
Or, WWII might have helped him...
Jan 13, 2010 23:23 PM
Man, I haven't seen grok used in years. Go Martians!
Jan 12, 2010 12:23 PM
I'd just like to thank you for the Calvin & Hobbes quote.
Jan 12, 2010 14:19 PM
I think one area that can be expanded is "types" of pitching motions and effects of pitchers career.
Jan 13, 2010 09:58 AM
To answer your question, I think the most underreported aspect of baseball is minor league injuries. The confluence of your job (prospects) and will carroll's job.
Jan 13, 2010 13:06 PM
To be clear, if my job is expertise with regard to prospects, I think we're all in trouble.
Jan 13, 2010 13:23 PM
I distinctly remember watching Johnson's perfect game in the seventh inning and thinking 'this isn't fair, there's NO WAY they're ever even touching him'--and they didn't. I'm not sure anyone was even close to getting a hit in that game.
Jan 16, 2010 20:00 PM
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A Composite Leading Indicator of Tunisian Inflation
This paper investigates the possibility of constructing a composite leading indicator (CLI) of Tunisian inflation. For doing so, partial information about future inflation rate provided by a number of basic series is analyzed first. Based on the correlation analysis, a few of these basic series are chosen for construction of composite indicator. Empirical results show that the deviation from long???term trend of two monetary aggregates (M1 and M3), short???term interest rate (TMM), real effective exchange rate and crude petroleum production, are important leading indicators for inflation rate in Tunisia. Accordingly, based on monthly data on these basic series, one composite indicator is constructed and its performance is assessed by using turning point analysis, granger causality tests, and impulse response functions. The results indicate that our composite indicator is useful in anticipating changes in inflation rates in Tunisia.
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|01 Mar 2010
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Mulled Wine-Poached Apples Recipe
For a satisfying touch of sweetness at the end of a meal without a heavy dessert, try these ruby red apples. The spice and wine sauce makes them very special.&$151;Taste of Home Test Kitchen
- 1 bottle (750 milliliters) merlot
- 1/2 cup Mulling Spices
- 6 medium apples, peeled and cored
- 1. In a Dutch oven, bring wine and Mulling Spices to a boil. Reduce heat; carefully add apples. Cover and simmer for 15-20 minutes or just until apples are tender, turning once.
- 2. With a slotted spoon, remove apples to a large bowl. Bring wine mixture to a boil; cook, uncovered, until liquid is reduced to about 1/2 cup. Cool. Pour over apples; cover and refrigerate for at least 1 hour before serving. Yield: 6 servings.
Nutritional Facts
1 poached apple with 4 teaspoons syrup: 240 calories, 0 fat (0 saturated fat), 0 cholesterol, 12mg sodium, 38g carbohydrate (32g sugars, 2g fiber), 0 protein.
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© 2017 RDA Enthusiast Brands, LLC


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AN IT worker has been banned from staying at a Basingstoke hotel for writing "There's a large snake in my trousers" on a customer comment form.
Jason Payne stayed at Hilton Basingstoke, in Old Common Road, Black Dam, on Saturday, February 8, for a friend's birthday.
The 35-year-old computer programmer, from London, booked his room using the booking.com website. On the comments section, he wrote: "There's a large snake in my trousers. Hope that's OK."
He said hotel staff laughed when they read the comment when he checked into the hotel.
But on Tuesday last week, he received an email from Cathrin Wurst, the hotel's front office manager, advising him staff would "not be able to accept any future bookings" from him.
She said the hotel was not willing to accept comments that put staff in an "uncomfortable situation" and added they were neither appropriate nor funny.
She told Mr Payne: "At reception, the team members are required to confirm any requests or comments the guests have made in their bookings, which means any comment you make will most definitely get read (out), and I cannot interpret putting a comment like this on to a booking in any other way than trying to embarrass the person who will read it."
Mr Payne told The Gazette: "I think she's a fuddy-duddy, taking really what was a puckish remark far too seriously, and she has no sense of humour.
"It was a joke. I have heard far worse said on CBBC and on TV shows like Loose Women and Jeremy Kyle. The only person who was ever going to see it was an adult, and they are exposed to far worse than 'There's a snake in my trousers'."
He added he has posted the reply on the internet, on sites such as Twitter and Reddit, and sent an email to staff at the investment bank where he works with the hotel's reply.
In a statement, the hotel chain confirmed the incident took place and said the decision was taken "at the discretion of the hotel team".
The statement added: "Hilton Basingstoke continues to operate a legitimate pet-friendly policy, and the guest is welcome to check in at the many other properties in the Hilton Worldwide portfolio."


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Contact Stokes Mortgage Capital today to find out what makes us stand out from the competition! Reaching us is easy. Simply call us at 323-223-1000 and speak with one of our mortgage consultants.
APPLY NOW to complete our secure online loan application and receive priority processing!
Stokes Mortgage Capital
Ph: (323) 223-1000Privacy Policy


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Travel along the Garden State Parkway and the Atlantic City Expressway long enough and you'll notice them: bridges that seemingly span nothing.
On the Atlantic City Expressway, there's one near milepost 13 in Hamilton Township, behind the Timber Glen condominium complex.
That bridge seems to serve little purpose other than to provide a 40-foot-tall graffiti canvas for youths. A meandering dirt road starts on Lombard Street by the housing complex, but after going under the highway it peters out about 100 yards later, in a tangle of mud, downed trees and apparent illegal dumping.
There are several more bridges on the Garden State Parkway that span a whole lot of nothing.
One is at about milepost 5.1 in Middle Township and another is at milepost 23.1 in Upper Township. Both provide access between quiet residential communities and the tidal marsh.
A third, at milepost 36.3 in Egg Harbor Township, is behind the Cardiff Center, and also sports an impressive coat of graffiti.
It's all the stranger, considering that these cost money to build. The truth is that all of the mystery bridges are remnants of a time when there were a lot more trains and a lot fewer cars, according to detailed maps from the New Jersey Department of Transportation called straight-line diagrams.
On those maps, the Atlantic City Expressway travels over a railroad line belonging to the "Penn Reading R.R." That was the train that used to deliver supplies and passengers to the nearby Atlantic City Race Course, a line that was apparently in operation when the expressway opened in 1964.
The last train ran on that line in October 1967, according to the local railfan website SJRail.com, and the rails were taken up in 1974. The dates are based on railroad management orders from the time and personal observation, said Mike DiMunno, the site's manager. These days, all that's left of that line is a stub that crosses Aloe Road in Galloway Township and dives into the woods behind the old Lenox China factory on Tilton Road.
Similarly, the DOT diagrams show the parkway bridges cross now-vanished tracks belonging to the "Penn Reading Seashore R.R."
The bridge in Middle Township spanned the former rail link to Wildwood, while the one in Upper Township carried cars over one to Ocean City. While the parkway opened in 1954, the last passenger train in Wildwood was in December 1972, according to SJRail.com, and the final freight train ran in June 1974. The line was officially abandoned in February 1976 and the tracks pulled up in 1977.
The Ocean City line closed in October 1981 when the train bridge over Crook Horn Creek broke. NJ Transit officially abandoned it the next year.
Rails still lie beneath the Egg Harbor Township bridge, although they are thickly crusted with orange rust and buried beneath pine needles. These rails abruptly end at the Black Horse Pike, and the Atlantic County Bikeway uses the old railroad right of way on the other side of the highway.
While no trains pass under this bridge, trains still serve industrial customers east of the bridge several times a week.
An occasional story about life in the region that just doesn't make sense. If you have an idea for a Nonsensical, email email@example.com.
Contact Derek Harper:
Follow @dnharper on Twitter


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Botanist's Glossary
In everyday language, we refer to plants by their common names. L'OCCITANE has personalized this glossary by including information about the traditional uses of these plants – the inspiration behind many of the L'OCCITANE True Stories. This glossary details a collection of approximately 150 plants used in the L'OCCITANE formulas, and was written with Laurence Chaber and Pierre Lieutaghi from the Association EPI*.


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The Balmain Raffia Panel Monk dress shoes are detailed with patent leather,monk with tonal raffia woven panel,and adjustable buckle strap at vamp. Aged silver-tone metal toe piece. Contrast stitched welt and rubber crepe wedge sole. They come in black and are imported from France. These are crispy.
Price:$1,250 USD
Buy Here..http://www.barneys.com/on/demandware...ault/Home-Show


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Have HVAC Questions? Ask an HVAC Expert for Answers
GMS90453BXA not sure if the O is O or 0 ( letter or number) but that is on the tag inside the unit on the left side so this is hopefully correct now
Yes, we had turned off the unti since the we saw that it was outside where the unit was frosted up so then the fan would continue to run with the controls on auto and off which made my grandpa think it was the thermostat then the blower motor would come on and off on and off and you would hear a clicking noise on the furnance. So, we then thought it was the capacitor. Also, want to mention that i was at work and my wife was home claimed that grandpa changed a fuse in the unit and that there is two fuses, I can only find one which she claijms is not the one grandpa changed. The one I found is good though but the one she claims was changed i cant find
Both answers are yes
I have a paper clip and am listening to do whatever you tell me to
THsi new therm is digital and has no switch to turn off....to turn it on auto digitally it turns cool on, which is since this one has no switch to click on auto.....however, I did go try the test to the R and G on the circuit board and nothing is happening....just worried I have not done right w the termostat
Nothing happening
Purple fuse is good and my wife is holding the switch in when i ask her to
Yes, immediately
thats correct
THis did kick the blower motor on! yeah! So.....???
so just leave the wires cool h n line h connected
cool h to eac doesnt work


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