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State Advocacy Issue
Updated July 2011
This is a summary of the laws that AVMA is aware of governing state pharmacy boards' authority to regulate the sale of veterinary prescription drugs.
In a December 19, 2006 decision, the Missouri Supreme Court ruled that the Missouri Practice of Pharmacy Statute could not be read to cover the retail sale of veterinary prescription drugs used for treating animals. The court found that because the statute did not discuss the retail sale of veterinary prescription drugs, nor did it define "drugs" or "patients", it was unwilling to infer, or read into the statute, a legislative intent to regulate veterinary prescription drugs. This decision led to legislation adopted in 2011 that gives the pharmacy board explicit authority over the retail sale of veterinary drugs. It also adds a licensed veterinarian to the board's advisory committee and gives the committee authority to make recommendations on rules and regulations dealing with veterinary legend drugs.
A survey of state pharmacy laws and regulations found that several other states such as California, Delaware, Indiana and Massachusetts have laws which specifically regulate the sale of veterinary prescription drugs and give the authority to the Board of Pharmacy or, in the case of Indiana, to the Board of Animal Health. Additionally, the majority of states do define the term "drug" to include those used in the cure, diagnosis, mitigation, treatment or prevention of disease in man or animal. After further research, it was found that in the overwhelming majority of states, it is apparent that the state's Board of Pharmacy has authority over the retail sale of veterinary prescription drugs. There are, however, a few exceptions.
For example, Iowa does not include animal drugs in the definition of drugs, but it does state that a person other than a pharmacist, physician, dentist, podiatric physician, and veterinarian may not dispense prescription drugs or controlled substances unless they are licensed by the Board. In Maryland, it is not clear whether or not the Board has authority over the sale of veterinary prescription drugs, unless one could argue that they are included in the definition of prescription drugs, which are specifically regulated by the Board. In Wyoming, it is clear that a veterinary drug retailer selling controlled substances is under the authority of the Controlled Substances Act, but there seems to be a void with regard to controlling veterinary prescription drug retailers.
However, with the exception of the court decision in Missouri, no other state was found to have expressly or implicitly determined, either legislatively or judicially, that veterinary legend drugs may be dispensed by non-regulated individuals.
Copyright ©
2017 American Veterinary Medical Association


text:
Why Most Madden Mobile Hack Fail
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subset: commoncrawl


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AI was wondering if anyone could please suggest what can be used to achieve the scalloped design going around the cake tiers in these pics, if I don't have the specific cutter?....thank you!
This is probably not the same, but it is similar:
or this:
If you're going for the rope/string scallops between the bouys(sp?) it's easy to take two thin ropes of fondant and twist them together.
If you mean the lifesaver/round things w/red on them again it's very easy to use two glasses of different sizes or depending on how big you need them use a *large* tip and small one to cut the round shapes.
No need for special tools you might only use once or twice :)
Thank you!!! The frill cutters is probably what I'd need. Found a Wilton mold as well that has a scallop design... wilton is coming out with some pretty neat molds!


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TWO of Hereford United's heroes from last season will be linking up with the Hereford United Supporters Trust (HUST) team.
Former caretaker boss Pete Beadle and assistant Steve Jenkins will be offering their support to the HUST team.
And former United striker Steve Guinan has confirmed he is hoping to get on his boots to play for the HUST side against Worcester City.
Former striker Trevor Benjamim is also planning to be involved in the match against Worcester City.
Speaking earlier today, Beadle said: "I have spoken to Jenks this morning and we are keen to get involved to show support for the rest of the team from last season."
"It is Jenks' birthday today, and he thinks he might be too old now to put on his boots."
HUST will be travelling to Ledbury Town on Monday night to play their first match of the season (7.30pm kick-off).
They will be playing against Worcester City at Malvern Town on August 3; Pegasus Juniors at Old School Lane on August 5; and a Mayor's XI at Hinton.
Former Hereford United chief Graham Turner has agreed to manage the Mayor's XI against HUST on a date to be confirmed


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Anue's flexible per-port licensing may be more economical, because IT doesn't have to pay for ports that won't be used. The base configuration Anue 5204 1-Gb box with four ports licensed is $17,000; the 5236 10-Gb box with four ports starts at $25,000. Licenses to activate additional ports are $800 per port for both models. Gigamon's basic GigaVue-420 (with four 1-Gb ports) lists for $14,995; the 10-Gb GigaVue-2404 (with eight 10-Gb and four 1-Gb ports) has a list price of $45,000. Each GigaVue supports four expansion slots, with various copper/fiber options and network taps for passive monitoring.
The process of setting Layer 2-4 filters is both the most important function of a network monitoring switch and the biggest difference between the Anue and Gigamon offerings.
Creating a simple filter that matches IP source and destination, or TCP and HTTP ports, is a straightforward process with both systems. However, management interfaces--Gigamon's CLI approach versus Anue's GUI--make all the difference in the time it takes to use each vendor's offering. Anue requires only dragging a line between two port objects within the GUI, which then pops up a filter dialog. You fill in the fields as prompted. The interface also includes mouse-over tips and contact-sensitive help.
Creating the same type of filter within Gigamon takes a couple of additional steps as well as mastery of the CLI's syntax. GigaVue users might need to budget some time with the user manual to ensure that they can access the switch's full benefits.
We found that generating sample filters using either switch wasn't much of a challenge in tests, but watching Internet traffic was. Like many organizations, we monitor the Internet for performance, diagnostic, and security reasons, using a variety of tools. Our three WAN ISPs are fed by four router ports with potentially asynchronous routes, so we need to combine these streams to ensure that we see all the traffic and filter it into high and low IP address ranges to balance the load on our monitoring tools.
Gigamon's Map feature combines filters, which can then be applied across multiple network traffic ports. Organizations can direct this combined and filtered traffic to specific tools without overrunning the bandwidth of their interfaces. However, we spent the better part of four hours and some trial and error to get the map and its filters defined and applied.
That said, we found Map to be a powerful problem-solver if you're facing complex collection and filtering snarls, and it's reusable on other interfaces, so it's worth the extra effort up front.
- Easy-to-use GUI speeds up network monitoring tasks
- Flexible configuration options can save companies money on licensing fees
- It filters a wide range of traffic
- Its lack of an API means customers will need bridging software, which will add to the total cost
- Gigamon earns its market-leader status with strong monitoring features and a wide array of configuration options
- CLI is automation-friendly, once you get the hang of it
- Switch handles high-density environments with one-box address and single point of management
- Gigamon has promised a GUI option, so CLI-shy organizations may want to wait before buying
In addition, Anue's Smart Filtering supports Boolean and "and/or" filters, including compound "or" and "and" combinations for complex selections. You don't need to worry about the order of a filter statement, as you would with an access control list or firewall rule.
Note that with power comes responsibility--Gigamon can put filters on incoming network ports or outgoing tool ports; however, if you're not careful, this could affect what traffic reaches each tool.
We tested a beta version of Gigamon's GUI and found it as easy to use as Anue's. Further, because the GUI is a Java applet, rather than a full-blown Java application, Gigamon won't require an installation on the desktop, meaning it can be used on any machine. However, this also means some functionality, like contextual right clicks for menus, won't be as rich.
The Gigamon GUI should make building filters a much faster process and will still let power users create the filter configuration in the CLI format behind the scenes.
Bruce Boardman is senior networking engineer at Syracuse University. Write to us at firstname.lastname@example.com.


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Greensburg Laurels & Lances
On the "Watch List": Jeannette's recovery. An official with the state Department of Community and Economic Development says Jeannette's fouled-up finances are dire but that the city can still turn things around in three or so years and avoid being declared a distressed city subject to state oversight. As Jeannette already is in Pre-Act 47 Early Intervention, we trust the state now will hold the city council's feet to the fire.
An observation: In a prompt turnaround, Irwin Council agreed to rehire ex-police Chief Joseph Pocsatko — fired without explanation — so he could tender his resignation under an agreement that supposedly contains no monetary consideration, officials say. But if he files for unemployment compensation, the borough will not oppose it. This, after Pocsatko threatened a wrongful-termination appeal. Ah, there's the nub of the rub, eh?
Lance: To a grossly ignored pothole. Almost directly in front of the Westmoreland County Courthouse, at the busy intersection of East Otterman and South Main streets in Greensburg, there's a left-lane pothole that's been steadily deepening for weeks. As potholes go, this is a tough one to miss. Let's get it filled before somebody blows a tire.
R.I.P.: Bishop Alphonse Mascherino. His accomplishments extend beyond founding the Flight 93 Memorial Chapel near the jetliner's crash site in Somerset County. He also was a fine goodwill ambassador for the thousands of people nationwide who visit the memorial. Bishop Mascherino, 69, died Feb. 15. From a profound tragedy, he created something positive and enduring.


text: Home > Computer Peripherals > Storage This article was posted on 07/31/2012 SATA SSD has enterprise-class performance The XceedIOPS2 SATA 6 Gbit/s SSD leverages 24 nm enterprise multi-level cell NAND flash and powerful error correction and detection firmware. The drives deliver up to 520 Mbytes/s of sequential read/write speed and up to 60,000/40,000 random read/write IOPS and are available in both 1.8 and 2.5 inch form factors.The unit comes in 50 to 400 Gbyte capacities with data reliability of less than 1 unrecoverable error in 1018 bits read. It features AES-256 encryption, data fail recovery, advanced thermal management features, and high reliability back-up power circuitry and takes 1800 ma active and 500 ma idle (typical). ($200 to $1,400 - available now.)by Jim HarrisonSMART Storage Systems, San Jose, CA, United StatesOEM email@example.com Learn more about SMART Storage Systems Related Articles How to burn any video to a DVD (in case you need reminding) IBM sends infected USB drives to customers; orders their immediate ... What are skyrmions and how can they save computer memory? How to create and mount disc images from CD files Add Comment Text Only 2000 character limit Please login to comment on the article


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A PET store in Kidderminster is marking rabbit awareness week with a series of workshops.
Pets at Home, Crossley Retail Park is holding the sessions on how to care for rabbits responsibly on Saturday and Sunday where highly-trained store staff will be on-hand throughout the day to provide information and advice on how to keep pet rabbits healthy and happy.
Store manager Emma Morgans said: "Rabbits are the UK's third most popular pet, making rewarding pets for adults and supervised older children.
"They're highly intelligent, social, interactive and fun creatures that are extremely clean and can even be litter trained. They have very individual and distinct personalities and often live more than 10-years-old, so having a rabbit as a pet is a long-term commitment."
Rabbit Awareness Week - which runs until Sunday - is an annual event where experts such as vets, pet retailers, welfare charities and manufacturers work together to educate people on how to give owned rabbits the best care possible.
This year's theme is "change one thing", to demonstrate how simple changes to a pet rabbit's environment, health, company, behaviour and diet can make a difference to its life.


text: Every semester, I try to take one random elective, a class that doesn't fulfill any sort or requirement for my degree but just seems interesting. These classes have ranged from Housing & Homelessness in the United States to the Communications Revolution to Engineering Design Visualization, Graphics, & Fundamentals of CAD. This semester, I'm taking a class…Continue reading


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Whether you're planning holiday dinners or looking to expand your recipe collection, here are seven of the best vegan cookbooks around. I have a ridiculous number of cookbooks, and these are the ones I find myself turning to again and again.
1. The Joy of Vegan Baking
When it was published, The Joy of Vegan Baking was the first vegan-baking compendium of its kind, and to this day it remains the best printed resource on the subject of vegan baking. Every time I bake, this is the first book I turn to. That's not so much for the recipes, though I've made the gingerbread scones more times than I can remember. Rather, the section "Better Than Eggs" is my go-to resource for recipe-appropriate egg substitutions, especially when I'm veganizing a recipe. One of the most helpful aspects of this book is Colleen Patrick-Goudreau's suggestions on when to use each of the dozen different types of egg substitutions detailed in the first chapter. Also peppered throughout the book are many helpful tips that offer valuable baking knowledge to both experienced and novice bakers alike.
2. Vegan Brunch
When I'm cooking at home, I have a particularly hard time finding recipes for breakfasts or brunches that really float my boat. Despite having a sweet tooth as ferocious as a yeti, I'm not particularly fond of overly sweet foods in the morning. When Vegan Brunch debuted, it was like a revolution in my frying pan; I'd never dared to imagine that a bowl of pureed tofu could lead to amazingly fluffy omelettes that are far tastier and versatile than their egg-based cousins. Vegan Brunch is still the only major book in the category of vegan breakfast cookbooks. Whether you're a fan of breakfast at any time of the day or a breakfast-is-only-for-the-morning traditionalist, this book should definitely be on your bookshelf.
3. Vegan Artisan Cheese
Although it will be likely be said many times to come by other cookbook reviewers, it bears repeating that Miyoko Schinner's Vegan Artisan Cheese is a ground-breaking work that will forever change how vegans and non-vegans alike view dairy-free cheeses. Applying culturing and aging techniques traditionally used in making their dairy-based equivalents, Schinner has created a variety of nut-based cheeses that resemble many traditional favourites, such as a creamy brie; an aged, sharp cheddar; a hard, grateable parmesan; and a fresh mozzarella very similar to the buffalo mozzarella used in Italian cuisine. Many of the recipes in the book require a bit of planning and, sometimes, a lot of patience as the cheeses age for days or even weeks to their perfect ripeness. Never again, though, will anyone will be able to say with any conviction, "I'd go vegan, except for the cheese. I love cheese!" With a little effort, nearly everyone can happily indulge in the delicious cheese-laden dishes of their dreams.
4. The Asian Vegan Kitchen
I admit that I am one of those cooks who judges a book—and its recipes—by its cover, and I was delighted with this book the moment I laid eyes on it. The sumptuous vegetable masala pictured on the cover hints at the delicious gems within the book's pages. Arranged according to country, the book includes traditional recipes from Burma, Malaysia, Indonesia, and Vietnam, among other countries. Mouth-wateringly gorgeous photos accompany some of the recipes, and the author includes the traditional names of the dishes along with their anglicized names. While there are a few unusual ingredients called for, such as angel mushrooms, candlenuts, and mizuna leaves, many of the dishes call for common ingredients that can be found in most well-stocked markets or purchased online. If you've never experienced the Thai fried noodle dish mee grob, the Indian semolina pudding sheera, or the Japanese spinach salad horenso no goma-ae, this cookbook will introduce you to a delicious new world of cooking.
5. Viva Vegan!
Viva Vegan! is a marvellous collection of traditional recipes from all over Latin America. Even if you're a seasoned lover of Latin foods, Terry Hope Romero's first solo cookbook will have you falling head-over-heels in love with the cuisine all over again. Offerings include popular foods such as Salvadorian stuffed pupusas, unforgettable Venezuelan arepas, Caribbean-inspired tostones, and tortilla-like Mexican sopes. Also included are simpler recipes, such as savoury homemade refried beans (far more affordable than store-bought cans of the stuff), addictive pickled red onions, and a delicious guacamole that, as with the author, will be the only one you ever make. Included throughout the book are helpful primers on subjects such as dried chiles, essential cooking tools, choosing plantains, and how to roll up burritos. Cookbooks as creative as this one will have you discovering many new much-loved dishes for years to come.
6. Vegan Yum Yum
There have been times I've been known to foolishly pass up a recipe because it sounded boring and—as my imagination was lacking—there was no accompanying picture to help whet my appetite. Bright, crisp, glossy photos of recipes are a sure-fire way to get almost anyone excited about food, and this is where Vegan Yum Yum excels above most other vegan cookbooks. One hundred and seventy-four of the book's 290 pages feature gorgeous, detailed full-colour photos of many of Lauren Ulm's beautiful creations. Some of the book's stand-out recipes—of which there are many—include mini blueberry tarts with lemon cream, the much-lauded Hurry Up Alfredo, Chinese broccoli wontons in ginger-soy broth, smoky miso tofu sandwiches, and chard Florentine on toast points. Vegan Yum Yum is simply a gorgeous and inspiring example of how the average person can bust-a-move in the kitchen and easily create some very satisfying food. If ever there were a cookbook to convince someone on the spot that vegan cuisine is both enticing and delicious, this would be it.
7. Veganomicon
There has never been another vegan cookbook more massively popular the world over than Veganomicon. As the name implies, the book is the magnum opus of vegan cuisine, becoming as significant a reference to novice and seasoned cooks alike as The Joy of Cooking has become a mainstay in the world of continental American cuisine. It's not just the amazing array of recipes offered in the book that make it a notable work; it's also the easy-to-navigate layout of the text, as well as the book's helpful headnotes and endnotes that make this cookbook a must-have. While I personally don't need yet another cookbook with an introduction that tells me how to stock a pantry, Veganomicon differs from other books in that it offers up useful introductions on subjects such as "How to Cook a Grain"—that section highlights a number of different grains, their uses, and, of course, how to cook them. Also incredibly useful is the appendix, which arranges the recipes in the book according to icons that denote the recipe types, such as gluten-free recipes and recipes under 45 minutes. Even if you're not much for cooking and don't have more than a cookbook or two to your name, adding Veganomicon to your bookshelf will ensure you need not ever look further for dinner inspiration again.


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Keepsake Cake Server & Fork Set
$ 47.95
The Personalized Keepsake Cake Server & Fork Set is a beautiful set for your special day. Perfect for weddings, showers and anniversaries. This cake server and fork has beautiful vintage detail. The cake server can be personalized two custom lines or a single initial, the forks are engraved with "Mr." and "Mrs."
May be engraved with two first names and wedding date (max of 24 characters per line) or two script custom lines (max of 24 characters per line), or a single script initial on the server at No Additional Cost. Forks automatically engraved with "Mr." and "Mrs."


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Questions? 800.926.2906
for The Temporary Relief Of Symptoms Associated With Female Hormonal Imbalance And Menopause And As An Adjunct To Hormone Replacement Therapy: Hot Flashes, Excessive Sweating, Headache, Fatigue, And Irritability.
1 Tablet Cont.:
sanguinaria 3x,
sepia 4x,
sulfur 4x,
ignatia 4x,
cedron 4x
ana 30 Mg;
stannum 12x
60 Mg;
lachesis 12x
90 Mg.
in General, 1 Tablet Dissolved Under The Tongue 3 Times Daily.
or 3-4 Times Daily, At The Start Possibly Every 1-2 Hours And Additionally At Every Hot Flush: 1 Tablet Dissolved On The Tongue.
form In Which Supplied And Package Size:
bottle Containing 100 Tablets.
pharmalogical And Clinical Notes;
constituents Indications:
sanguinaria (turmeric)
climacteric Disturbances, Hot Flushes, Uterine Polypi, Vasomotor Disorders, Periodical Recurrence Of Headaches.
sepia (cuttlefish)
climacteric Disorders, Nervous Exhaustion, Depression, Apathy, Chronic Inflammation Of The Uterus And Adnexa, Hyperhidrosis.
sulpher (sulphur)
reactant For All Chronic Diseases, Cell Activity Is Influenced Catalytically.
ignatia (st. Ignatiu's Bean)
lability Of Mood, Querulousness, Globus Hystericus, Migraine, Depression.
cedron (cedron Seeds)
periodically Recurring Neuralgia.
stannum (tin)
general Remedy For Debility, Conditions Of Nervous Exhaustion, Visceroptosis.
lachesis (bushmaster)
climacteric Disorders, Palpitations, Hot Flushes.
klimakt-heel Has Proved Effective In The Treatment Of Hormonal Manifestations Of Endocrine Deficiency, Especially In The Climacteric; It Does Not Act As Hormonal Substitution Therapy. By Means Of Klimakt-heel, Without Hormones, Biological Stimulation Takes Place Of The Ovaries And The Superimposed Endocrine Control System (hypothalamus, Interior Lobe Of The Pituitary Gland). The Therapeutical Effect Of Klimakt-heel Is Accomplished Through A Coupling Of Therapeutically Stimulating Active Substances Which, In Accordance With Burgi's Princple, Undergo Potentiatlon.
based On The Individual Homeopathic Constituents Of Klimakt-heel, Therapeutic Possibilities Result For The Treatment Of Manifestations Of Endocrine Deficiency Such As Hot Flushes With And Without Attacks Of Sudation, Palpitations, Pulsation Of The Blood Vessels, Sensation Of Globus, Dejection And Other Neurovegetative Symptoms (dystonia), Exhaustion, Neurosis, Depressive Or Melancholic Conditions Of The Menopause As Well As Climacteric Pruritus Vulvae (in Addition To Mercurius-heel And Mezereum-homaccord, Possibly Also Schwef-heel, Hormeel, Sulfur-lnjeel, Engystol, Galium-heel, Etc.).
after Possible Past Hormone Treatment, The Additional Parenteral Application Is Recommended Of Metro-adnex-lnjeel And Ovarium Suis-lnjeel (forte), Possibly Also Placenta Suis-lnjeel Fforte) Once To Twice Weekly As Mixed Injection I.m.
the Acids Of The Citric Acid Cycle, As Well As Engystol And Traumeel, Act Favorably In Combination.
these Statements Have Not Been Evaluated By The Food And Drug Administration.
this Product Is Not Intended To Diagnose, Treat, Cure, Or Prevent Any Disease.


text:
Ricky Wright
Posted by : February 7, 2013| On :
Wright was born Aug. 1, 1956, in Dallas, to Peggy and William Curtis Wright, and died Jan. 29, 2013, in Corsicana.
He was preceded in death by his father.
Survivors include his children, Jennifer Davidson, and husband Derek, Kristi Wright and Brian Soliz; mother Peggy Wright; brothers Lynn Wright and wife Judy Gay, Roy Wright; grandchildren Gage Bowman, Brenden and Lucian Soliz, Addison Rylie Davidson; many aunts, uncles, cousins, nieces, nephews and friends.


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Earby Youth Hostel weather map
- Recent locations
Your chosen location:
City of London
An error has occurred.
Weather type
Forecast summary
Regional forecast for North West England
Dry and bright with some showers.
This Evening and Tonight:
It will be a dry and bright end to the day, then tonight will stay mostly dry with clear spells, and it will be less humid than last night. A few showers are likely, especially towards dawn. Minimum Temperature 13 °C.
Further showers are expected during the morning, but they will tend to become more isolated in the afternoon. Away from the showers there will decent sunny spells. Maximum Temperature 21 °C.
Outlook for Friday to Sunday:
On Friday there will be sunny spells and one or two showers. Sunny spells are likely over the weekend though some showers are also likely. Generally feeling warm.
Updated at: 1606 on Wed 23 Aug 2017
UK forecast for the next 5 days
Rain clearing from the northeast. Drier and fresher elsewhere.
This Evening and Tonight:
Rain, which will be heavy at times, will linger over the Northern Isles overnight. Elsewhere it will be dry across much of the UK with clear spells, although a few showers are also expected, mainly in western parts.
England and Wales will be mostly dry and breezy with sunny spells. Showers are likely in parts of Scotland, Northern Ireland and the far west of England.
Outlook for Friday to Sunday:
Across the north and west it will often be breezy with sunshine and showers. Further south and east it will often be dry, with warm sunny spells and lighter winds.
Updated at: 1608 on Wed 23 Aug 2017
Outlook for the UK over the next 6-30 days
UK Outlook for Monday 28 Aug 2017 to Wednesday 6 Sep 2017:
On Monday, a band of thick cloud some outbreaks of rain and strong winds are likely to spread eastwards across the country. The rain will be heaviest in the NW and it may remain dry and warm in the southeast, although there is a small risk of one or two thundery showers continuing. Into next week, we are likely to see unsettled conditions, with spells of wet and windy weather, particularly in the northwest. It will be drier in general across the southeast, although there is a risk of some thundery showers here at times. There may be a longer spell of more settled weather in early September. Temperatures will probably be near normal, though perhaps warm at times in the south.
Updated at: 1343 on Wed 23 Aug 2017
UK Outlook for Thursday 7 Sep 2017 to Thursday 21 Sep 2017:
During this period, we are most likely to see changeable weather conditions featuring across the United Kingdom. However, there will be some dry and fine weather at times too. On balance spells of rain and strong winds are likely to dominate in the north and west, with drier and brighter weather more common in the south and east. Temperatures will probably remain close to normal for the time of year in most parts, though they may become warm or very warm at times in the south which may generate some thunderstorms.
Updated at: 1343 on Wed 23 Aug 2017
Location Details
Earby Youth Hostel
Location: 53.9151, -2.1283
Altitude: 172.0 m above mean sea level


text:
Write some Articles -- 2
Budget $30-250 USD
I want someone to write 15 real estate investing articles that are UNIQUE and Grammatically correct. These are going to go on site to try and get an Adsense account approved.
Awarded to:
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45 freelancers are bidding on average $166 for this job
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Columnist Makes Worst Fake Dating Profile Ever and Gets Unbelievable Response
A writer from LA, Alli Reed, wanted to experiment a little bit with online dating. She created the worst online dating profile ever! And, in the first 24 hours she received over 150 responses!
Her fake name was 'aaroncarterfan,' on OKCupid.com and she used a picture of her best friend who is a model, 'hoping to prove that there exists an online dating profile so loathsome that no man would message it,' despite how attractive the picture is.
In the post she said she is 'mean, spoiled, lazy, racist, manipulative and even a gold digger.' She said 'I'm really good at convincing people im pregnat (sic) lol,' and she ended 'the first things people usually notice about me' with, 'Prolly (sic) the first thing they notice is the drink Im throwing in there (sic) face LOL.' Nice.
She said she likes to drink, do drugs, and 'keep America American.' One of her pictures is her in a bikini in a pool with the caption 'I'm PEEING right now!'
She also said she was unemployed but couldn't live without '$$$' and cars and went on to say she enjoyed knocking coffee out of homeless people's hands because it was 'sooooooo funny.' Her parents pay for her law school, but she's not really going to classes at all and 'its awesome.'
After so many men looked past her horrific profile and messaged her anyway, she set her sights to getting them to stop talking to her, so she responded to their inquiries with more ridiculousness! She told one gentleman caller that she likes to pretend to be a 14-year-old on Facebook to make fun of her sister's friends because 'LMAOOOOO bullying is fun.'
But, the guy responded with: 'Lol your so funny. hahaha. you a sexy devil lol :) so dose ur sis know about it? Any plans for the weekend? Btw what's ur number so we can text?'
To another man, she wrote: 'ya lol i fake bein pregnant so much that im like amazing at it, i deserve a nobel proze for it lol. ppl will give u whatever u want if they think ur pregnant SPECIALLY if they think there the dad, omg lol (sic)'
The men kept messaging.
So she threatened to ruin their lives. She told them she'd give them mermaid tattoos and pull their teeth out. It seems that only turned them on more. Hmmmm….
In her article about her experiment she said she could follow her first instinct and 'invest in a high-quality chastity belt and start collecting cats.' But instead she decided to 'stay optimistic and instead offer an impassioned plea.'
She gives some advice to women – 'Don't settle. Figure out how to be happy with who you are and then look for someone who makes your great life even better.'
Not sure I'd come out of that experiment with a lot of hope! Nice work Alli!
Check out the article with the picture – click here.


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- Description
In Marlo Schalesky's breathtaking tale of soulmates divided by tragedy and united by love, Maddie teeters between life and death. Her husband Paul begs her to remember their love, regain consciousness, and come home. She recalls pushing Paul away—just before their love found voice and just as her blindness stole her hopes and dreams. And then she remembers Paul's unselfish, undying love.
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A Love Like Ours (A Porter Family Novel, Book #3)
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Between 1963 and 1979 SAT-verbal scores declined 50 points. This is often attributed to change in the demographics of test-takers, a much broader segment of the population now takes the SAT tests. However, Cornell University researchers Donald P. Hayes, Loreen T. Wolfer and Michael F. Wolfe point out inconsistencies in that explanation, and suggest that simplification of school textbooks lies behind the decline in student's reading comprehension and verbal achievement.
They describe a simple, low-cost experiment that school districts can carry out themselves to test how textbook difficulty affects their student's verbal achievement levels.
Hayes et al. point out three discrepancies between students' performances and the explanation that it is due to the changing demographics of students taking the test. First, scores did not drop during the 1950-1963 period when the population taking the test changed the most and grew the fastest.
Second, scores should have leveled off when the growth and composition of test takers leveled off (remaining fairly stable at 50 percent of the high school population between 1963 and 1979), yet this was precisely when the big decline in scores occurred. Third, the number of students scoring over 600 should have remained about the same.
Instead the entire distribution of verbal scores, from top to bottom, shifted to lower levels. There are now 35 percent fewer students scoring over 600. The number scoring over 700 dropped from 17,500 in 1972 to just over 10,000 in 1993, even as the number taking the test grew. Highly selective colleges report mean verbal declines of about 40 points.
Simplified textbooks may be to blame
Hayes et al. suggest a different reason for the decline, which was first described by Jeanne Chall in 1977. A change in educational philosophy after World War II encouraged publishers and educators to make schoolwork more accessible by reducing the pace of instruction, lowering student workloads, assigning fewer written papers, and simplifying textbooks.
When publishers simplified textbooks, they reduced the depth and breadth of academic knowledge covered, and in doing so, limited the number of uncommon words in texts. After 11 years1 exposure to simplified textbooks, a cumulative deficit in students1 knowledge and advanced verbal skills is likely, according to these researchers.
This hypothesis of cumulative deficit implies a time lag between the production of simplified texts after World War II and a significant effect on students1 learning. The majority of new textbook series did not appear until after 1950; most schools continued to use the harder, older series until the mid-1950s. Children therefore had been exposed to the simpler readers for several years by the time the SAT-verbal scores began to drop in 1963.
Text simplified after WWI and WWII
These researchers analyzed more than 800 texts from all major and most minor publishers, using between 10 and 30 pages of each text (at least 1000 words) as a sample. The most difficult readers generally were published before 1918. After World War I and again after World War II, reading levels were simplified. Today's mean sixth-, seventh- and eighth-grade readers are simpler than fifth-grade readers were before World War II.
Sentences also were shortened from about 20 words to about 14 words for grades 4-8. Since this period of simplification, however, the difficulty of primary readers has been restored to pre-World War II levels, while middle and high school readers remain much simpler than before World War II. Science textbooks have remained about the same over the years.
While acknowledging that changing demographics probably accounts for a portion of the downward trend, Hayes et al. conclude that simplifying textbooks has had an unexpected and undesirable effect on student1s knowledge and skills that is reflected in the dramatic decline in SAT-verbal scores. This hypothesis predicts that unless there is a significant increase in the reading level of schoolbooks, achievement will continue at this low level for many years.
An Experiment
These researchers propose a simple and inexpensive experiment to test their hypothesis. They call for large school districts to match pairs of same-grade classes in different schools. The districts must be large enough to detect the small accumulating effects of comparing large numbers of matching classes using less-difficult and more-difficult texts over a four-year period. If the hypothesis is proven correct, then schools would be in a position to insist that publishers raise the levels of new textbook series.
Schoolbook Simplification and Its Relation to the Decline in SAT-Verbal Scores, American Educational Research Journal, Volume 33, Number 2, Summer 1996 pp. 489-508.
Published in ERN November/December 1996 Volume 9 Number 5


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Hey there, time traveller!
This article was published 22/2/2013 (1642 days ago), so information in it may no longer be current.
Announcements for Faith Briefs must be in our office by Monday, 4 p.m., prior to the intended date of publication. Due to space restrictions, publication is not guaranteed. Please post information on website: http://wfp.to/events
-- Winnipeg Central Aglow meeting, Feb. 25, 7 p.m., Best Western Inn and Suites, 1714 Pembina Hwy. Video teaching by Joyce Meyers on Power Thoughts. $7.
-- The Church of St. Stephen and St. Bede, first of a four-night Lenten Study with Dr. Richard LeBrun, St Paul's College, speaking on The Mystery of Jesuits, Feb. 25, 7 p.m., 99 Turner Ave. 204-837-9812.
-- Lenten Jazz Vespers featuring Neil Watson and Friends, Feb. 28 and March 7, 7 p.m., Crescent Fort Rouge United Church, 525 Wardlaw Ave.
-- World Day of Prayer Services, March 1. Prepared by the women of France. Theme: I was a Stranger and You Welcomed Me. Information or a list of churches: Diane 204-253-5949 or firstname.lastname@example.com.
-- Spiritual Wisdom on Dreams, Eckankar Centre, 470 Provencher Blvd., March 1, 7:30 p.m., March 8, 7:30 p.m., March 15, 7:30 p.m. Free discussion classes to gain insight and guidance regarding your inner spiritual experiences. Information: 204-233-4281 or www.eckankar-mb.ca.
-- Manitoba Christian Writers Association meets March 2 and April 6, 1:15-4 p.m., Bleak House Centre, 1637 Main St. Information: Irene firstname.lastname@example.com or 204-334-7780.
-- Special Services with Dave Duel, Faith Temple, 968 Notre Dame Ave., March 1, 7 p.m., March 2, 7 p.m., March 3, 11 a.m. Free-will offering.
-- Public lecture, CMU Chapel, 600 Shaftesbury Blvd, March 4, 7:30 p.m. Anabaptism as a Missional Movement, by Stuart Murray (Church Planter, Author: The Naked Anabaptist), free.
-- Breakfast with woman of God, Marcia Barrett, Assiniboine Gordon Inn on the Park, 1975 Portage Ave, March 5, 9:30 a.m., Aglow Southwest, $8.75.
-- Community Health and Well Being Program, Temple Shalom, 1077 Grant Ave., March 6, 1:30 p.m. Is it a Mood or a Mood Disorder? Presented by Tara Brousseau-Snider, executive director, Mood Disorders Association of Manitoba. Free.
-- Living Room Immanuel Pentecostal Church, 955 Wilkes Ave., second Sunday of the month, March 10-Dec. 8, 5 p.m., a faith-based support group for persons living with mood disorders.
-- The Upside Down Kingdom Tour, Calvary Temple, 400 Hargrave St., March 12, 7:30 p.m., with Shane Claiborne and singer/songwriter Jason Gray. Information: worldvision.ca/upsidedownkingdom, 1-800-268-5863 ext. 3648, $35/person, $30/2 people, $25/3 or more people.


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The specially designed facility will store a series of collections by the pioneers of photography.
It will hold more than 20,000 images of historic importance, including works by trailblazers such as David Octavius Hill and Robert Adamson.
Temperature and humidity levels will be controlled to provide a stable, cool environment for the images.
The facility also includes Thomas Annan's famous pictures of the crumbling closes of Glasgow, commissioned by the City of Glasgow in 1866.
David Weston, keeper of special collections, said: "We have a wealth of images that mark important periods and individuals in history and these need to be preserved.
Special collections
"The collections exemplify the profound documentary value and aesthetic beauty of photography.
"The store, made possible with significant funding from The Wolfson Foundation, will be an invaluable addition to our special collections section of the library."
Other materials stored include The Pencil of Nature by Henry Fox Talbot, the first book to be illustrated with photographs and a substantial body of photographs reflecting the life and interests of James McNeill Whistler.
Photographic negatives made by William Speirs Bruce on expeditions to the Arctic and Antarctic between 1899 and 1914 are also featured, as well as the photographic record of the life and creative output of James Paterson, one of the 'Glasgow Boys'.
Most Popular Now | 56,514 people are reading stories on the site right now.";


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Revlon Cream Blush Reviews
Glides on SmoothThis is one of the few cream blushes I have tried and really liked. It is very easy to use and the product goes on the skin very smoothly. The colors are fairly saturated and you can build on the skin. This does provide a very natural look. I was especially impressed by how well it blended into skin. I wish it wore a little bit longer - I get about 4 hours of wear out of this, but overall I think this is a fantastic product. — 5 years, 2 months agoTheLacqueredLady | 751 reviews
This review is: Helpful | Not helpful | Inappropriate | 5 of 6 people said helpful
Rosy GlowI heard alot of people raving about this- so I got and I really like it! The texture is really smooth and not too thick. It stays on pretty long and the packaging with the pop out mirror is really cute! — 5 years, 11 months agoaly7 | 396 reviews
This review is: Helpful | Not helpful | Inappropriate | 6 of 7 people said helpful
NaturalThis drugstore blush by Revlon felt velvety soft on my fingertip and looked very natural on my face. The Rosy Glow color looked like a naturally flushed face and although difficult to open, I may purchase it again. — 5 years, 3 months agoleo1999 | 678 reviews
This review is: Helpful | Not helpful | Inappropriate | 2 of 3 people said helpful
Lovely colorI received this Cream Blush in Rose Glow 09 from Revlon and I like it enough to buy again unless it is too expensive ( I don't know the price yet). It is really creamy and easy to apply with the fingertips, it gives a smooth and silky finish and the color is lovely. Definitely a good buy, I recommend it. Ah, and I like the pop-out mirror, I find it very practical. — 3 years, 11 months agohamolla | 78 reviews
Fool ProofThis blush is a wonderful example of how cream blushes are often more blendable, and natural looking than powders. The smooth, creamy consistency makes application virtually fool proof. The natural flush it gives also lasts all day. One trick: Use a blush brush to apply this cream. It will give an airbrushed finish. — 8 years, 3 months agoAmberDB | 189 reviews
This review is: Helpful | Not helpful | Inappropriate | 4 of 4 people said helpful
amazing packaging and great texture cream!haven't found a shade that i like yet in this series but the texture and consistency and wearability is amazing. I would recommend this to a friend if you can get a good color for you. i purchased rosy glow, because i thought that it was the universal go to color for blush but i was SO off. — 5 years, 11 months agoMrsBrunetteBeauty | 89 reviews
This review is: Helpful | Not helpful | Inappropriate | 4 of 6 people said helpful
ImpressedI usually use NARS and this is really good compared to it, especially considering the price. It doesn't last all day but it's easy enough to reapply. It blends well and the color is natural but buildable. I will buy again. Wish they had more colors. — 3 years, 10 months agoDianalizavala | 17 reviews
Hard to blendLet me start by saying that I genuinely wanted to love these. I love the entire colorstay collection from Revlon. However....it's just not the case with these cream blushes. I felt like it was hard to find the right tool to use to blend these (I tried makeup sponges, wedges, various brushes, etc and finally ending up settling on a mini stippling brush as my best bet for blending this out. However....read more..once you get it blended out to a natural look, then its rather sheer & not worth all of that work. I do like the color selection, but won't be buying any more due to the problems that I have had with them. — 4 years, 8 months agomeganelkins0728 | 35 reviews
Pretty colors and easy applicationI have this blush in Just Peachy (peach) and First Blush (dark reddish pink). Both colors easily blend into my fair skin for a natural flush, which is pretty amazing considering how different the colors are. My skin is sensitive, and the blush does not clog my pores or irritate my skin. The mirror is nothing special, but I have used it on occasion when I'm on the go and can't pop into a bathroom to check my makeup. I would definitely by this product again. — 7 years agokatieq | 39 reviews
This review is: Helpful | Not helpful | Inappropriate | 4 of 4 people said helpful
Great Blush With Natural FinishI was really skeptical about cream blushes, mainly because I thought they were like foundation. But this is great; I use a wedge to apply it, and it looks perfect. It's very natural looking, and is WAY better than some powder blushes that make me look like I got slapped across the face. I was surprised that it was from Revlon; I hardly ever use their products because they're a bit expensive. Thi...read mores isn't oily, thick, clumpy or watery. It's got the perfect balance between cream and lotion so it goes on smooth. The color isn't totally true though. I bought 'Rosy Glow' because the rest of them look too dark, but this color comes out more peachy than rosy. It stays on for about 2 hours, but I found pinching my cheeks helps for a burst of color when I need it. I still love it, though (: — 7 years, 7 months agoMissAdventurex3 | 15 reviews
This review is: Helpful | Not helpful | Inappropriate | 3 of 3 people said helpful
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My Reasons for Reporting This


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Knowledge Management Software PLC
16 February 2001
16 February 2001
Knowledge Management Software plc ('KMS')
& Orbital Software Holdings plc ('Orbital')
Merger talks in progress
The Boards of KMS and Orbital announce that they are in
preliminary discussions concerning a merger of the two
companies. It is anticipated that any transaction would
be effected by an offer to be made by HSBC Investment
Bank plc on behalf of KMS resulting in Orbital
shareholders being issued approximately 1.219 new KMS
shares for each existing issued Orbital share and so in
proportion for any other number of Orbital shares held.
On the basis of the share price of KMS at the close of
business on 15 February 2001, this equates to 98.7p per
Orbital share.
The Boards of KMS and Orbital believe that a merger
could provide benefits in terms of the compatibility of
product offerings, the potential for enhanced product
development and in cost savings.
The Boards wish to emphasise that at this stage it is
not certain that the transaction will complete.
A further announcement will be made in due course.
KMS is being advised by HSBC Investment Bank plc and
Orbital is being advised by Broadview International
Knowledge Management Software plc Orbital Software Holdings plc
Stuart Whistance 0161 227 1120 Ian Ritchie 0131 348 3000
Tim Jackson-Smith Kevin Dorren
HSBC Investment Bank plc Broadview International Limited
Simon Murphy 020 7336 9000 Tom S. Anthofer 020 7968 3700
Clive Rates Roger Manship
The Directors of KMS and Orbital accept responsibility for
the information in this announcement. To the best of the
knowledge and belief of the Directors of KMS and Orbital
(who have taken all reasonable care to ensure that such is
the case) the information contained in this announcement
is in accordance with the facts and does not omit anything
likely to affect the import of such information. This
announcement has been approved for the purposes of section
57 of the Financial Services Act 1986 by HSBC Investment
Bank plc.
HSBC Investment Bank plc, which is regulated in the United
Kingdom by The Securities and Futures Authority Limited,
is acting exclusively for KMS and no one else in relation
to the offer and will not be responsible to anyone other
than KMS for providing the protections afforded to
customers of HSBC Investment Bank plc, or for providing
advice in relation to the offer.
Broadview International Limited, which is regulated in the
United Kingdom by The Securities and Futures Authority
Limited, is acting exclusively for Orbital and no one else
in relation to the offer and will not be responsible to
anyone other than Orbital for providing the protections
afforded to customers of Broadview International Limited,
or for providing advice in relation to the offer.
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昨日UNITED FRONTサポートで大阪でドラム叩かせてもらいました🙋 pic.twitter.com/NMPWkEKXvF
— KOTA (@DrKar73) April 30, 2017
Call for Contributions for Project 416 "Dear friends and allies, In recent years, the Singapore punk scene has witnessed the loss of all our dedicated independent and supportive spaces....
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Glymed Plus Serious Action Skin Gel
- 1 reviews See the Breakdown
- Product Info | Add Your Review
Glymed Plus Serious Action Skin Gel Reviews
every day necessityI get breakouts here and there, but I put this on my whole face because it does not dry out my skin and keeps breakouts down to nothing. This will not dry out your skin and it's loaded with good stuff for your face. It's a dual action worker for acne and aging! — 9 years, 1 month agobre_bre | 43 reviews
This review is: Helpful | Not helpful | Inappropriate | 2 of 2 people said helpful
Home » Reviews » Face » Blemish + Acne Control » Glymed Plus Serious Action Skin Gel
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Cairo Almonds
READY IN: 50mins
Recipe by PalatablePastime
Low carb snack; best made a few hours before serving.
Top Review by Annacia
These are yummy. I was leery about the salt amount but went ahead and after a good amount shook of all was good. Whats not to love about fresh roasted, salted and nicely pepper hot nut's? These will make a great munchy/snack/party tray addition. Really glad I gave them a try. :D
See Discussion:1 Review
Ingredients Nutrition
- 1 teaspoon butter or 1 teaspoon olive oil
- 1 1⁄2 cups blanched almonds
- 3 tablespoons coarse sea salt
- cayenne pepper
Directions See How It's Made
- Preheat oven to 225°F.
- Toss almonds with oil and spread on a nonstick baking sheet.
- Toast for about 45 minutes, then toss with salt while warm. Wrap tightly in foil or waxed paper and allow to sit for a couple hours, then shake off excess salt.
- Season to taste with cayenne pepper.


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The first half had me thinking I had the wrong anime. …
- Tags: Adaptations, AIC, Image Gallery, Kotoura-san, Moe, Web Comic
Comment on Kotoura-san "Surprisingly Funny" by Rally:
The first half had me thinking I had the wrong anime.
Recent comments by Rally:
- Adorable Mashiro Nendoroid:
If they do a Benio nendo, does it come with a bonus horrified face for Mashiro?
- Haiyore! Nyaruko-san W Loathsome Loli Anime:
Satomi Arai's narration (she is also Shanta-kun's VA) is meant to parody "Ookami-san to Shichinin no Nakama-tachi", where she provides identical narration to each episode. She also mentions "the girl with the ominous eyes" (Ookami) and "the shy lazy boy" (Ryoshi)
- Top 25 Seiyuu With The Most Beautiful Voices:
Indeed. Any list of this type without Wakamoto in the top five is automatically invalid.
- Haiyore! Nyaruko-san W Apes All:
Ha! I see what you did there…
- "Akane Kisarazu" JGSDF AH-1S Ita-Cobra Formidably Cute:
In order: SH-60J, C-1, MU-2J, YS-11, DHC-8-300 (Coast Guard), OH-1 Ninja, Eurocopter Super Puma (Coast Guard), OH-6E, UH-60JA, UH-1J, CH-47J. Yep. Military otaku as well.


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Bankruptcy Law
Bankruptcy Law Questions? Ask a Bankruptcy Lawyer.
I hope that the information which I provided was helpful to you. However, if I have not fully answered your question, please post me back on this thread with a clarification.
Best wishes for a successful outcome. If you have additional questions, please do not hesitate to submit them to me directly.
Thank you, FLAandNYLAWYER
The one with MBNA I fully intend to settle as per the proposal. It's not an issue.
however I look at the other one i need to ask the question.
How likely in your experience or knowledge would it be for this to be domesticated in the US or indeed the UK creditor filing a law suit against me in the US. Would this be very costly for them to do this. What is the minimum I could do to prevent them taking any action?
I am correct in assuming that unless there is a court proceeding it will not adversely affect my credit rating in the US
okay thanks - only another few questions -
1) How long would it take for a UK Creditor to file a suit in the US on this subject.
2)What is the minimum i can do to prevent them from taking action.
I'm willing to offer to pay a minimal amount.
To put my cards on the table........ I have been in dispute with these creditors and they have not been very flexible with me and i was told by Scots Pro Lawyer that the debt was not enforcable in the US, so I decided to leave and ignore it, again the advise given.
I have a great life here in the US, comfortably financially, getting married next year and
planning to start a family. I refer to question 2 .... I can offer to pay a nominal fee but will not be able to make what they would call minimum monthly payments without it serioulsy affecting the quality of my life. From this perspective if I offered to make nominal payments would that prevent them from taking action.? or do you recommend anything else.
one more for you
When I get married I will be moving into my fiancee's house, it's her house and her asset , I have and will have no claim on it. in this case will her house be classed as an asset. if so how can i avoid this.
so even if they do file suit .....it's not too late to work out a payment plan. ?
Thanks for your advise you've been a great help.
That is correct. And in Texas, wages and homestead are protected.
My pleasure. Please request me directly if you need additional assistance.
Thank you,
I'm sorry but I have two more question and in need of simplification to ease my mind.
It's good to know that in Texas wages and homestead are protected.
So by working out a payment plan will also protect the only assets I have which is my car and household goods?
So all in all ..... there is a lot of time and water to go under the bridge before I need to get into a payment plan which in the end would protect any assets I have?
How long would it take for something like this to actually register in the US ?
It may never actually happen. However if it does, you will be served with a summons and complaint and have 20 days to respond.
Please click ACCEPT/BONUS so that I can get credit for my work


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Roarie-yum Model
Derfla PaintingsArtist/Painter Male Boone, North Carolina, US
My Website: Derfla PaintingsMy MM URL: http://www.modelmayhem.com/derfla
Mayhem # 2537098
About MeMy name is Kent Paulette and I'm a 30-year-old artist painting under the name Derfla. I use uninhibited, energetic brush strokes and knife marks to create paintings with thick icing-like textures. My studio is in the mountains near Boone, North Carolina. I've created over 600 paintings and I have hundreds of paintings hanging in venues spread out across the region.
My favorite subjects to paint are women and one of my biggest goals is to capture their movement. I'm always looking to collaborate with female models.
I've posted my artist statement below so you can read about my process:
From the start of this journey I've opted out of symbolism, instead searching for a more direct way to express one core idea. This has led me to give control over to a process that allows the painting to come to life organically. The painting is able to occur as an uninterrupted event subject to the whims of chance.
I try to apply the paint without hesitation or indecisiveness, and without reacting to what has already been painted. In that all important moment when the paint touches the canvas, I tend to look away, allowing myself to get lost in it. These measures help to fend off the frustration and anxiety that may arise from any lingering tendency to control the outcome.
I do not try to conceal the process, but rather let it be revealed to anyone who is drawn to a closer examination of the painting. The thick texture and visible knife marks proclaim exactly how the painting was created.
I do not try to form an emotional connection with the subject matter. It is simply a passive element in the process, nothing more. This deliberate lack of emotion creates the room needed for my emotional argument, my emotional plea.
Have you worked with Derfla Paintings? Add Credits for Derfla Paintings! >>
Roarie-yum Model
Michael E Cohen Makeup Artist
Peter Keresztury Photographer
ABillings Artist/Painter
figuredraw... Artist/Painter
Kristie California Model
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An Open Study to Evaluate the Efficacy, Safety of Clevudine Monotherapy or Adefovir and Clevudine Combination in Patients With Chronic Hepatitis B
This study has been completed.
Bukwang Pharmaceutical
Information provided by:
Bukwang Pharmaceutical
ClinicalTrials.gov Identifier:
First received: December 19, 2010
Last updated: December 16, 2014
Last verified: December 2014
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This is an open study to evaluate the efficacy, safety of clevudine monotherapy or adefovir and clevudine combination in patients with chronic hepatitis B.
|Chronic Hepatitis B
|Drug: Clevudine 30mg Drug: Clevudine 20mg+Adefovir dipivoxil 10mg Drug: Clevudine 20mg
|Phase 4
|Study Type:
|Study Design:
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|An Open Study to Evaluate the Efficacy, Safety of Clevudine Monotherapy or Adefovir and Clevudine Combination in Patients With Chronic Hepatitis B
Resource links provided by NLM:
MedlinePlus related topics: Hepatitis Hepatitis A Hepatitis BU.S. FDA Resources
Further study details as provided by Bukwang Pharmaceutical:
Primary Outcome Measures:
- Proportion of patients with HBV DNA levels < 300 copies/mL [ Time Frame: 24 week ]
Secondary Outcome Measures:
- The change of HBV DNA form the baseline [ Time Frame: 24week, 48week, 96week ](log copies/mL)
- Proportion of patients with HBV DNA < 300 copies/mL [ Time Frame: 48week, 96week ]
- Proportion of patients with ALT normalization [ Time Frame: 24week, 48week, 96week ]
- Proportion of patients with HBeAg loss and/or seroconversion [ Time Frame: 96 Week ]
|Estimated Enrollment:
|Study Start Date:
|March 2010
|Study Completion Date:
|February 2013
|Primary Completion Date:
|August 2012 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 1
Clevudine 30mg
Drug: Clevudine 30mg
Clevudine 30mg
Other Name: Levovir 30mg
Experimental: 2
Clevudine 20mg+Adefovir dipivoxil 10mg
Drug: Clevudine 20mg+Adefovir dipivoxil 10mg
Clevudine 20mg+ Adefovir 10mg
Other Name: Levovir 20mg+Adefovir 10mg
Experimental: 3
Clevudine 20mg
Drug: Clevudine 20mg
Clevudine 20mg
Other Name: Levovir 20mg
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patient is 18 years and older.
- Patient is documented to be HBsAg positive for > 6 months.
- Patient is HBV DNA positive with DNA levels ≥ 1×10^5 copies/mL within 30days of baseline.
- Patient has ALT levels ≥ 1×ULN
- Patient who is able to give written informed consent prior to study start and to comply with the study requirements.
Exclusion Criteria:
- Patient is currently receiving antiviral, immunomodulatory, cytotoxic or corticosteroid therapy.
- Patients previously treated with interferon, peg-interferon or other immunomodulatory within the previous 6 months.
- Patients previously treated with clevudine, lamivudine, adefovir, entecavir, telbivudine, Tenofovir or any other investigational nucleoside for HBV infection.
- Patient with clinical evidence of decompensated liver disease (Total bilirubin < 2.0mg/dL, Prothrombin time < 1.7(INR), Serum albumin≥3.5g/dL)
- Patient is coinfected with HCV, HDV or HIV.
- Patient has a history of ascites, variceal hemorrhage or hepatic encephalopathy.
- Patient with clinical evidence of hepatocellular carcinoma
- Patient with previous liver transplantation
- Patient is pregnant or breast-feeding.
- Patient has a clinically relevant history of abuse of alcohol or drugs.
- Patient has a significant immunocompromised, gastrointestinal, renal,
- hematological, psychiatric, bronchopulmonary, biliary diseases excluding asymptomatic GB stone, neurological, cardiac, oncologic(except HCC)or allergic disease or medical illness that in the investigator's opinion might interfere with therapy.
- Patient has creatinine clearance less than 60mL/min as estimated by the following formula: (140-age in years) (body weight [kg])/(72) (serum creatinine [mg/dL]) [Note: multiply estimates by 0.85 for women]
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01264354
Please refer to this study by its ClinicalTrials.gov identifier: NCT01264354
|Korea, Republic of
|Samsung Medical Center
|Seoul, Korea, Republic of
Sponsors and Collaborators
Bukwang Pharmaceutical
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on August 16, 2017
|Responsible Party:
|Byung Chul Yoo/Samsung Medical Center, Samsung Medical Center
|ClinicalTrials.gov Identifier:
|NCT01264354 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 19, 2010
|Last Updated:
|December 16, 2014
Additional relevant MeSH terms:
Hepatitis A
Hepatitis, Chronic
Hepatitis B
Hepatitis B, Chronic
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Hepadnaviridae Infections
DNA Virus Infections
Adefovir dipivoxil
Antiviral Agents
Anti-Infective Agents
Reverse Transcriptase Inhibitors
Nucleic Acid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Retroviral Agents
ClinicalTrials.gov processed this record on August 16, 2017


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VOTERS in Clacton will be the ones who decide on Mr Carswell's future as their MP, he said.
As well as defecting to UKIP, the former Tory MP has resigned his seat.
It means voters in Clacton will go to the polls to elect a new MP.
Mr Carswell will stand in the election for his new party.
"As someone who's always answered directly to the independent-minded people of Essex, there is only one honourable thing for me to do," he said.
"I must seek permission from my boss, the people of Clacton. I will now resign from Parliament and stand for UKIP in the by-election that now follows."


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For some, a path to student loan forgiveness
NEW YORK — Wish you could make your student loans disappear?
"There needs to be more awareness about these programs," says Betsy Mayotte, director of regulatory compliance at American Student Assistance, a nonprofit that helps borrowers manage their student debt.
The organization released a loan forgiveness guide this year on its website. The Consumer Financial Protection Bureau, a government watchdog, released a guide over the summer to draw attention to programs.
The programs are not a quick fix. Instead, they enable borrowers to erase their remaining student debt after several years of payments. Most are tied to certain low-paid professions, such as teachers or public defenders, and have other restrictions. Here's a snapshot of several options.
Public service
This program is for those who work in federal, state or local government jobs, or at a nonprofit that's been designated as a 501(c)(3) tax-exempt organization. The CFPB estimates that a quarter of the country's workforce falls into those categories. Individuals must have high student loan balances relative to their income.
Anyone who makes 120 on-time monthly payments toward their student loans and works in a qualifying job for 10 years can apply to have the remaining balance forgiven. The amount of the loans forgiven is not taxed, under current tax law.
Only those with federal Direct Loans will qualify for this program, but some loans, such as the Federal Family Education Loan (known as FFEL) and the Perkins Loan can be consolidated into a Direct Loan. If you don't know what type of federal loan you have, you can find out at nslds.ed.gov.
The program was established in 2007, so no one has received loan forgiveness yet.
Income-based repayment
Borrowers can qualify for reduced monthly payments, and after 25 years the remaining balance is forgiven. The forgiven amount is taxed as income, which means you will likely have to pay a sum to the IRS that's lower than the amount forgiven.
The program is for those whose federal student loan debt is high relative to income and family size. Your lender will ultimately decide if you are qualified. There are other rules, such as which types of federal loans qualify.
Pay as you earn plan
Borrowers can apply to have their monthly payments reduced, and after 20 years of payments, the balance is forgiven. Any forgiven amounts are taxed as income. This program is for those with a high level of federal student loans compared to their income, and who took out their first federal student loan after Oct. 1, 2007.
Other programs
Depending on your job, you may be able to get help with your loans.
Teachers, for example, should see if they're eligible for the teacher loan forgiveness program. They must work at a qualifying school for five consecutive years to receive up to $17,500 in forgiveness on certain federal loans.


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The NCA (National Communication Association) will host its 99th Annual Convention at the Marriott Wardman Park Hotel in Washington DC on November 21-24, 2013.
If you need hotel accommodations in Washington, DC, be sure to visit the American Guest House which is a bed and breakfast inn located just a few minutes from this event. We have great rooms which include WiFi and a complementary breakfast. We are rated in the top ten B&B hotels in the entire Washington DC area and when you stay with us you will see why!
Directions to the Marriott Wardman Park Hotel
View Directions to the Wardman Park Marriott in a larger map
Joseph, Innkeeper


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- Hanna-Kaisa Korolainen
- Jenni Tuominen
- Maija Louekari
- Vuokko Eskolin-Nurmesniemi
- Sanna Annukka
- Noora Niinikoski
- Mikko Laakkonen
- Mika Piirainen
- Maija Isola
- Aino-Maija Metsola
- Anna Danielsson
- Fujiwo Ishimoto
- Erja Hirvi
- Anu Penttinen
- Anu Susi
- Sofia Järnefelt
- Sami Ruotsalainen
- Satu Maaranen
- Anna Teurnell
Maija Isola
Maija Isola was a tremendously versatile and bold artist. She interpreted the events of her era from her own unique perspective and foresaw future trends.
Her body of work includes over 500 prints – a brilliant selection of patterns representing different themes and techniques. She drew inspiration from traditional folk art, modern visual art, nature and her countless trips around the world.
In 1970, Maija Isola wrote to her daughter from Paris:
"Bon soir children. I'm having a wonderful time these days. I've started working. Once again, I feel as if I'll never find the time to do even a fraction of all the things I want to do. – – I had a huge floral still-life of sorts spread out wet on the floor, waiting to be rolled up ... paints in yoghurt pots, and newspaper everywhere, and flowers in vases on the floorboards. I bought those to paint from on Pentecost. Large deep-red roses, small and fragrant, curiously furry pink roses, yellow, orange and white poppies, cowslips in various shades of purple, black tulips and tiny carmine flowers whose name I don't know."


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Stan Sheetz honored; ExxonMobil makes personnel changes.
Stan Sheetz, president of Altoona, Pa.-based convenience chain Sheetz Inc., has been named Western Pennsylvania Ernst & Young Entrepreneur of the Year in the consumer products and services category.
"When the first convenience store opened it was cutting edge. Today, they're everywhere, and to succeed in the business you have to differentiate your store from all the rest," said Sheetz. "That's where entrepreneurship comes in -- at Sheetz we differentiate ourselves by listening to our customers and employees."
Sheetz was one of 24 finalists chosen by an independent panel of judges comprised of local community and business leaders. He and the seven other Western Pennsylvania winners will now be considered for the national Ernst & Young Entrepreneur of the Year Award. Winners in several national categories, as well as the overall national Ernst & Young Entrepreneur of the Year, will be announced in November at the annual awards gala in Palm Springs, Calif.
In other people news, Daniel S. Sanders, president, ExxonMobil Chemical Co., and vice president, Exxon Mobil Corp., will retire on Aug. 31 after more than 43 years of service. Sanders, 64, joined the company in 1961 and was elected to his current job in January 1999.
It is anticipated that the board of directors will appoint Michael J. Dolan as president, ExxonMobil Chemical Co., and elect him a vice president of the corporation effective Sept. 1. In the interim, Dolan will become executive vice president, ExxonMobil Chemical Co., effective Aug. 1. Dolan is currently deputy to the president of ExxonMobil Refining & Supply Co. Dolan, 50, joined the company in 1980. During his career, he has managed many of the major product groups in ExxonMobil Chemical Co. and served as its regional director for the Middle East and Africa.
Stephen D. Pryor, currently executive vice president, ExxonMobil Chemical Co., will become deputy to the president, ExxonMobil Refining & Supply Co., effective Aug. 1. Pryor, 54, joined the company in 1971 and has held his current position since January 2002.


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|Home > National News > Article
"We are a free people," he said.
Police were unaware of the proper interpretation of the Constitution when they charged the boy.
State Parliament is debating an opposition bill making it illegal to burn the Australian flag. The Liberal leader, Colin Barnett, said such actions were immensely hurtful to many people.
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Also in National
Wife wins $700,000 damages over HIV husband
ALP president: Give us policies, not a beauty contest
'Al-Qaeda link' baggage handler's passport confiscated
Chemical salesman sorry about dealings with Amrozi
Drug bust that stung the taxpayer for $84,000
Only the poor are paying too much tax, says ACOSS
Safety fears lead to rural flights threat
DPP says sorry over 'murder' victim who's alive
Running legend to give back half of $1.1m damages
Rivkin goes to hospital then to ground
Secrecy lifted on subsidies for drugs
Fears for Senate as rubber stamp
Police station evacuated after woman presents mortar shell
Councils under the gun to merge and share the wealth
Last Post for bank statements
Students scorn GP pay and inflexible hours
Farmers face another winter of discontent
Pressure mounts over free public transport scheme for school students
Death threat against protected witness
Boy not guilty of burning flag
Thwarted ocean rowers brought ashore
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THE more serious topic of business was put aside in favour of comedy at the last meeting of the year of the Bolton professionals' curry club.
As a Christmas special instead of the usual business oriented speaker, two comedians took the microphone to entertain more than 70 guests.
Salford comic Greg Cook and Bolton comedian Dave Wolfe delivered two entertaining post lunch comedy spots.
The professionals' curry club was set up last year as a joint enterprise by KBL solicitors and RSM Tenon in order to provide a convivial quarterly talking shop for Bolton-based business professionals.
The event is both useful for networking and to listen to guest speakers' opinions on the world of business and finance and how Bolton can benefit.
For many business people the quarterly meeting is a great way to meet contemporaries they might only see infrequently and to discuss a variety of business opportunities.
Sean Greenhalgh, manager of newly opened branch of Swedish bank Handelsbanken in Bolton, said: "It's just a great way of meeting up with fellow professionals.
"When we have different speakers I find it a great way to find out what's going on in Bolton and the wider business world."
Hosts and sponsors of yesterday's lunch were restaurateurs Subhash and Geeta Kotecha, who own Spice Valley in Horwich and Spice Valley in the Valley, where yesterday's lunch was held.
Mr Kotecha said: "I think it's great for people to do some networking with fellow business professionals and people can keep in touch with what's going on in and around Bolton."
Phil Stephenson, managing partner at KBL, said: "It's a great, well attended event, where members of the local professional business community can get together to share ideas.
"There are lots of opportunities where businesses and professionals can meet up and see what's going on in the business community in Bolton."
The membership is selective and those invited to attend are usually partners, decision makers or senior managers in a variety of local professions. At the moment the club is open to bankers, accountants, solicitors, independent financial advisers, insolvency practitioners, estate agents, commercial property agents and developers.
Representatives from Bolton Council, including regeneration and development director Keith Davies and chef executive Sean Harriss, usually attend.
Guest speakers have included Robert Hough from the North West Development Agency, Keith Davies and Sean Harriss from Bolton Council and The Bolton News editor Ian Savage.
Future speakers lined up for next year include representatives from the University of Bolton, Media City and MIDAS


text:
|Product ID
|Est. Delivery:
|Sep, 6 - Sep, 12
|10 days · Refund Money
|1 year(s)
|Bismarck, ND
|Seller Since:
|Feb 11, 2014
Have one to sell? Sell Yours Now
ThermaZone is a powerful and practical pain relieving device that uses thermoelectric technology to provide heating and cooling therapy where and when you need it, without the use of ice. Our technology satisfies a clear unmet clinical need - safe, effective, and targeted localized treatment with highly precise temperature management and consistency. If you have any questions please call us at (701)223-9936 or Toll Free (800)355-2956.
Prescribed by Orthopedic Surgeons to reduce bruising and swelling that may occur after knee surgery. Cryotherapy is proven to reduce bleeding, swelling and bruising and improve range of motion. Procedures may include:
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|Store Location
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All items take 7-10 business days or 14 calendar days to arrive inside the USA via ground shipping.
Item(s) must be returned within 10 days after arrival.
Refund will be given as: Refund Money.
Products must be returned in new and unused condition and must include any and all product packaging, instruction manuals, blank warranty cards and or accessories.
Returns must include customer's complete name, address, phone number and explanation as to why the product is being returned.
Returns received that do not meet the above criteria will be shipped back to the customer at their expense.
All products must be returned within 10 days of receipt or a 20% restocking fee will apply.
Balkowitsch Enterprises, Inc, reserves the right to change our return policy at any time without, incurring any obligations to make the reserved terms applicable to products previously sold.
This return policy does not apply to special order, personalized, custom made or homeopathic products.
Warranty Duration: 1 year(s).
All items have a 1 year warranty unless otherwised specified.


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OAKLEY — Vineyard owner Stan Planchon saw flashlights bobbing in the dark among rows of his zinfandel vines early Monday and knew right away that a grape heist was under way.
His property, six acres of old vines planted near the intersection of Empire Avenue and Laurel Road, was being pillaged. Before police arrived, thieves made off with more than 1,200 pounds of prime grapes grown for California zinfandel giant Rosenblum Cellars, he said.
It was about 1:30 a.m. and his wife had called him to the kitchen to see what was happening, Planchon said.
"I decided to go down and confront these guys, but first of all, I had her call the police," said Planchon, 90, whose family has owned the vineyard since 1902.
Planchon said he drove down and found two vehicles apparently being used by the grape thieves and was able to park his truck to block one of them.
At least two thieves made off in the other getaway vehicle, a truck, Planchon said.
Oakley police said they recovered at the scene a vehicle reported stolen out of Antioch, covered in gas and bullet holes, but released no suspect information Wednesday.
What made the caper particularly unusual, Planchon said, was that his vineyard is surrounded by a six-foot fence he built himself. It's the only vineyard in the area with such a fence, so why would thieves trouble themselves with the added obstacle?
Planchon speculated it was because they knew his grapes were valuable.
"That particular vineyard is about 180 years old," Planchon said, and wines made from its grapes have been featured in Wine Spectator magazine. They're mostly zinfandel grapes, he said, with a field blending that includes the French varietals Alicante Bouschet, which adds rich color to the wine, and Mourvedre, which adds spicy flavor.
Eighty-one plants had been stripped of their grapes, he said. At about 15 pounds of fruit per plant, which sell for $1.25 per pound, he lost roughly $1,500 worth of old-vine, specially tailored grapes.
The vineyard's fruit is featured in wine made by Rosenblum Cellars, an Alameda-based winemaker known for inexpensive, high-quality zinfandel.
Quoted on the Rosenblum website, winemaker John Kane said, "To me, the Planchon vineyard is very historical. It's a really nice wine from the old head prune vineyards, showing great signs of smoked bacon. I'm glad we were able to save it from the development out in Contra Costa County."
Police had no one in custody and named no suspects Wednesday. Anyone with information on the crime can call county dispatchers at 925-646-2441.
Contact Sean Maher at 925-943-8013. Follow him at Twitter.com/OneSeanMaher.


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Potato Chive Soup Recipe
The homespun flavor in every spoonful of this delicate cream soup disguises its easy preparation. Based on a favorite restaurant soup, this version comes in handy when there are extra mashed potatoes from a holiday meal. —Linda Harrington, Hudson, New Hampshire
- 1/2 cup butter, cubed
- 1 medium onion, chopped
- 1/2 cup minced fresh chives
- 1 carton (32 ounces) chicken broth
- 2-1/2 cups mashed potatoes (with added milk and butter)
- 1 cup heavy whipping cream or half-and-half cream
- Oyster crackers, optional
- 1. In a large saucepan over medium heat, melt butter. Add onion; cook and stir until crisp-tender. Add chives; cook 2 minutes longer. Remove from the heat; stir in broth and potatoes.
- 2. In a blender or food processor, process mixture in batches until smooth. Return to the pan; stir in cream. Heat through (do not boil). Serve with crackers if desired. Yield: 8 servings (2 quarts).
Nutritional Facts
1 cup: 293 calories, 25g fat (15g saturated fat), 81mg cholesterol, 791mg sodium, 14g carbohydrate (3g sugars, 1g fiber), 3g protein.
Reviews for Potato Chive Soup
Average Rating
© 2017 RDA Enthusiast Brands, LLC


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Columbia Highlands, in print!
Welcome to "Columbia Highlands: Exploring Washington's Last Frontier," written by Craig Romano, 2007, and published by Conservation Northwest and The Mountaineers Books.
Exploring Washington's last frontier
The Mountaineers Books and Conservation Northwest are proud to present Columbia Highlands: Exploring Washington's Last Frontier, the first book to highlight the Upper Columbia region of Washington in the northeast corner of the state.
Purchase a book for yourself or a friend!
The book, by noted outdoor writer Craig Romano and with thoughtful photography by James Johnston, Paul Bannick, and others, takes the reader on a photographic journey to the place where the Cascades meet the Rockies east of the Okanogan River in Washington. One hundred rich images portray an intimate portrait of the landscape, plants, animals, and people in a beautiful but largely undiscovered corner of the American West.
Protecting a landscape of forest, people, and wildlife
Through image and narrative, Columbia Highlands delves into the importance of protecting this rich landscape as a wildlife bridge for wolves, bears, moose, and lynx and other animals who must roam to survive. And it brings home the importance of protecting the social fabric of our rural communities, along the way highlighting one of the most successful community collaborations in the West, the Columbia Highlands Initiative. The book features biographies of people in the local community who are deeply connected to the land and its future.
Emerging here in the northeast corner of Washington is a new and compelling kind of conservation blueprint that preserves the health of the ecosystem while sustaining a viable rural economy and lifestyle.


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Wow, ABC1's Rake throws down the gauntlet with a knockout cast tomorrow night: Garry McDonald, Don Hany, Jack Thompson, Deborah Kennedy, on top of Richard Roxburgh, Damien Garvey, Matt Day, Danielle Cormack, Russell Dykstra. Truly impressive.
Cleaver's (Richard Roxburgh) affair with the Premier proves costly when her husband, A-G Cal McGregor (Damien Garvey) begins a campaign of harassment against him. David Potter (Matt Day) sues him for defamation, and, after the clown punch-up at Max's birthday party, he's persona non grata to Barney (Russell Dykstra) as well.
Meanwhile, Barney and Scarlet (Danielle Cormack) are having counselling. He's also busy defending Lawrence Fenton (Garry McDonald) – charged with fraud for posing as a board member around town in a campaign aimed against the corporate debasement of the English language.
Cleaver, meanwhile, is defending Damien Trengrove (Don Hany), who's accused of stealing two million dollars from a children's leukemia foundation run by his wife.
Cleaver arrives at ex-wife Wendy's (Caroline Brazier) as her book group discusses A Thousand Lies I Have Told by a new author, JM Doolan, and takes special notice of newly-divorced neighbour Sally (Katrina Hobbs). But both neighbour Sally and author JM Doolan have surprises in store for him.
Against his better judgement, Barney brings Cleaver in on the Lawrence Fenton case when Lawrence gatecrashes a global security conference being held by Cal McGregor for the British Home Secretary. David Potter uses the breach of security to embarrass the A-G, who then charges Lawrence with terrorism.
Cleaver is now defending an innocent ex-school teacher whom Cal is determined to prosecute, and a slimy corporate thief who Cal wants to set free.
8:30pm Thursday ABC1.