text:
ABI-009 Trial in Patients With Advanced Non-hematologic Malignancies
This study has been completed.
Celgene Corporation
Information provided by (Responsible Party):
Celgene Corporation
ClinicalTrials.gov Identifier:
First received: March 7, 2008
Last updated: October 25, 2016
Last verified: October 2016
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- Tabular View
- No Study Results Posted
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Detailed Description:
To determine the maximum tolerated dose (MTD) and dose limiting toxicities (DLTs) of ABI-009 given weekly; to characterize the toxicities of ABI-009; and to determine the pharmacokinetic parameters for ABI-009 when given on a weekly schedule.
|Solid Tumors
|Drug: ABI-009
|Phase 1
|Study Type:
|Study Design:
|Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Official Title:
|A Phase I Trial of ABI-009 (Nab-rapamycin) Administered Weekly in Patients With Advanced Non-hematologic Malignancies
Resource links provided by NLM:
Drug Information available for: Sirolimus Everolimus TemsirolimusU.S. FDA Resources
Further study details as provided by Celgene Corporation:
Primary Outcome Measures:
- Determine the maximum tolerated dose (MTD) and dose limiting toxicities (DLTs) of ABI-009 administered weekly and pharmacokinetic parameters for ABI-009. [ Time Frame: End of Study (EOS) and Follow Up ]
Secondary Outcome Measures:
- Efficacy of ABI-009 in this patient population [ Time Frame: End of Study (EOS) and Follow Up ]
|Study Start Date:
|December 2007
|Study Completion Date:
|June 2011
|Primary Completion Date:
|June 2011 (Final data collection date for primary outcome measure)
|Assigned Interventions
|Experimental: ABI-009
Drug: ABI-009
Other Name: nab-rapamycin
Detailed Description:
No extended description necessary
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Each subject must meet the following criteria to be enrolled in this study.
- Male and female patients with histologically or cytologically confirmed diagnosis of cancer which is not amenable to curative therapy.
- Patients with advanced non-hematologic malignancies for whom no standard therapy exists.
- Measurable disease by RECIST or evaluable disease (e.g., bone metastasis, pleural effusion, ascites, or lesions which do not fulfill RECIST criteria for metastatic disease)
- Off all therapy (inclusive of investigational therapies) for at least 4 weeks prior to study drug administration OR off all daily or weekly therapy (inclusive of investigational therapies) for at least 2 weeks prior to study drug administration and without any side effects associated with these therapies.
- Female patients of child-bearing potential must have a negative serum pregnancy test within 7 days prior to first study drug administration.
- Female patients who are postmenopausal must have 12 months of amenorrhea, surgically sterile, or must agree to the use of a physical method of non-hormonal contraception.
- Male patients must be surgically sterile or agree to the use of a barrier method of contraception.
- Life expectancy of > 3 months.
- ECOG Performance Status of 0-1.
- Patients must be able to provide informed consent indicating knowledge of his/her disease process, the investigational nature of the therapy, alternatives, benefits, and risks including potential side effects.
- Age ≥ 18 years of age.
- No major surgery within 4 weeks before treatment with ABI-009. (A biopsy is not considered major surgery).
- No chemotherapy, hormonal therapy, immunotherapy or radiotherapy within 4 weeks before treatment with ABI-009 (6 weeks for previous treatment with nitrosoureas, mitomycin, or extensive radiotherapy) and no immunosuppressive agents within 3 weeks before study entry (except corticosteroids used as antiemetics).
- No immunosuppressive agents within 3 weeks before study entry (except corticosteroids used as antiemetics).
Required Initial Laboratory Data:
- Hemoglobin > 9.0 g/dL
- WBC ≥ 3,000/µl
- ANC ≥ 1,500/µl
- Platelet count ≥ 100,000/µl
- Total Bilirubin ≤ ULN
- SGOT (AST) SGPT (ALT) ≤ 1.5 x ULN ≤ 1.5 x ULN
- Serum Cholesterol < 350 mg/dL
- Serum Triglyceride < 300 mg/dL
- Adequate renal function with serum creatinine < 1.5 mg/dL and/or creatinine clearance (cockroft formula) ≥ 60 mL/min.
- No active alcohol abuse, drug addiction, or psychotic disorders.
- No known concomitant genetic or acquired immunosuppressive diseases (such as AIDS).
- If obese, a patient must be treated with doses calculated using his/her actual BSA (The physician must be comfortable treating at the full BSA dose regardless of BSA).
Exclusion Criteria:
Subjects who meet any of the following criteria will be excluded from the study.
- Pregnant or nursing women.
- History of allergic reactions attributed to compounds of similar chemical or biologic composition including macrolide (e.g. azithromycin, clarithromycin, dirithromycin, and erythromycin) and ketolide antibiotics.
- Patients have not recovered from adverse affects of radiation therapy or investigational agent within previous 28 days.
- Uncontrolled intercurrent illness that in the opinion of the investigator would limit compliance and tolerance to study requirements
- Patients with known brain metastases or leptomeningeal tumor involvement.
- Receiving any of the following: concomitant antitumor therapy or inhibitors of CYP3A4.
- Patients with history of interstitial lung disease and/or pneumonitis.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00635284
Please refer to this study by its ClinicalTrials.gov identifier: NCT00635284
|United States, California
|Sarcoma Oncology Center
|Santa Monica, California, United States, 90403
|United States, Texas
|University of Texas M.D. Anderson Cancer Center
|Houston, Texas, United States, 77030
Sponsors and Collaborators
Celgene Corporation
|Principal Investigator:
|Ana M. Gonzalez, MD
|M.D. Anderson Cancer Center
|Principal Investigator:
|Sant P. Chawla, MD
|Sarcoma Oncology Center
More Information
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on August 23, 2017
Gonzalez-Angulo AM, Meric-Bernstam F, Chawla S, Falchook G, Hong D, Akcakanat A, Chen H, Naing A, Fu S, Wheler J, Moulder S, Helgason T, Li S, Elias I, Desai N, Kurzrock R. Weekly nab-Rapamycin in patients with advanced nonhematologic malignancies: final results of a phase I trial. Clin Cancer Res. 2013 Oct 1;19(19):5474-84. doi: 10.1158/1078-0432.CCR-12-3110.
|Responsible Party:
|Celgene Corporation
|ClinicalTrials.gov Identifier:
|NCT00635284 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Study First Received:
|March 7, 2008
|Last Updated:
|October 25, 2016
Additional relevant MeSH terms:
Anti-Bacterial Agents
Anti-Infective Agents
Antibiotics, Antineoplastic
Antineoplastic Agents
Antifungal Agents
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
ClinicalTrials.gov processed this record on August 23, 2017


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New Zealand court rules in favor of poker
In a groundbreaking ruling a New Zealand court has delivered a huge blow to opponents of online poker, and poker in general. The ruling comes on the heels of charges being filed that claimed .net poker site domains violated the Gambling Act of 2003. Judge David J Harvey dismissed all charges in the case and went on to further clarify the court's position on online poker, and on live tournament poker.
Not only did the court find that .net websites are not gambling sites, but it also found that they are not related to their .com partner sites.
Additionally the judge rules that poker tournaments –the APPT in particular—is not gambling because of the preset entrant's fee, and the prize-pool awarded at the conclusion of the tournament. The APPT came under fire because of PokerStars.net sponsorship of the tour.
The ruling could have ramifications across the globe as poker players seek to legitimize the game on a number of fronts, most notably that poker is a game of skill.
Here are Harvey's complete remarks:
"Firstly, the nature of the material in the advertisements made it clear that what was being advertised was free websites that do not involve gambling. Secondly, the .com website is not mentioned at any time. Unless the user knew of the existence of the .com website, no association could be made between PokerStars and that particular website. A third reason for rejecting the suggestion that .net and .com sites involve a distinction without a difference lies in the very internet itself….the navigational realties of the internet mean that there is a very significant difference between web addresses of any nature, be they .net .com and .org even although they may be associated with a similar domain name.".
"I do not agree that the way in which the APPT is structured amounts to gambling. It does not involve the payment of consideration based upon the outcome of the game. It involves the splitting of a sum of money derived from the payment of entry fees between the winning players. Although poker is usually associated with some form of gambling, because players do not make side bets on the outcome of each hand that element of wagering upon the outcome, or paying consideration or a stake, is not present".
Tags: Gambling Act of 2003, Judge David J Harvey, New Zealand court, New Zealand court rules in favor of poker
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subset: commoncrawl


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EXCLUSIVE: He co-created 24, in which Jack Bauer often saved the lives of fictitious U.S. presidents. For his next project, Bob Cochran is taking on a man who saved a sitting American president in real life: Allan Pinkerton. Cochran is developing Pinkerton, a 8-10-hour limited series for Starz about the famous spy and detective, with Gerard Butler on board to executive produce. Starz has commissioned a pilot script and a bible for the project, a fictionalized retelling of the exploits of Pinkerton, creator of the Pinkerton National Detective Agency, the first detective agency in the U.S. "He was an amazing guy — he took part in all the great sweeping events of the 19th century," Cochran said. Scottish-born Pinkerton, who emigrated to the U.S. at age 23, stumbled upon sleuthing in 1840s Chicago almost by accident. He served as head of the Union Intelligence Service, the forerunner of the U.S. Secret Service. As such, he guarded Abraham Lincoln on his way to his inauguration and foiled an assassination attempt on him in Baltimore. The little-known episode will be featured prominently in the series, Cochran said. Pinkerton also became "the spy master of the North" during the Civil War. His detective agency was hired by the railroad companies to go after outlaw gangs that were robbing trains, including the one led by the infamous Jesse James. Pinkerton caught many robbers but, in what is considered his biggest miss, he wasn't able to track down James. While working for the railroad companies, Pinkerton was also involved with the Underground Railroad, a network of secret routes and safe houses used mostly in the 1850s to smuggle slaves to freedom in Canada. "On one hand he was enforcing the law, and on the other hand he was breaking the law," Cochran said. "He was interested in right and wrong, not so much in the the law." At his agency, Pinkerton developed several investigative techniques that are widely used today, including "shadowing" aka survailance, "assuming a role" aka going undercover, as well as using mugshots and profiling. At the time of his death in 1884, he was working on a centralized database of all criminal identification records which is now maintained by the FBI. Cochran is executive producing Pinkerton with Angela Mancuso, who, as an executive at USA Network oversaw the network's mini-series Atilla the Hun, written by APA-repped Cochran. It starred CAA-repped Butler in one of his first lead roles. It was Mancuso who suggested to Cochran that they take the project to Starz and reach out to Butler who, like Pinkerton, is Scottish. The actor quickly came onboard as exec producer. Butler and his manager Alan Siegel will exec produce through their Evil Twins production company. Also executive producing And while Pinkerton is developed as a limited series, Cochran is leaving the door open for a potential second series.
Starz Develops Allan Pinkerton Limited Series With Bob Cochran & Gerard Butler
20 Comments
Starz is developing some very cool material. They're doing a great job competing with the likes of Showtime & HBO. Cochran/Mancuso have great taste so looking forward to seeing this. Hope the money lasts at Starz to see it through.
The Pinkerton Agency also supplied the gunmen that protected factories during strikes. They brutalized and killed the workers with impunity.
Hey Justin and Labor History,
Unions have been destroying countries around the world for the last 100 years with their unrealistic benefit demands and worthless work abilities! Anyone seen Greece or France lately? And guess what? It's coming to the U.S. in the near future. Get informed!
Carol Lombardini, is that you?
Cool, love Gerard Butler!
Why can't Gerard Butler star as Pinkerton? He can for once use his lovely Scottish accent.
Strange, I read a feature script a couple months back that was identical to this story and pitch – think it was even shopped as a series focusing on the Lincoln attempt – ideas sure do get recycled in this town
Oh great – a show glamorizing privatized law enforcement. Pinkerton was the forefather to guys like Eric Prince; they were businessmen first. If they couldn't turn a profit, then they weren't involved.
I love what Starz is up to these days!! Between Butler's new show and Neal McDonough's new show – they are coming up with some cool material.
a) I missed the Neal McDonough project, hope it has nothing to do with making believe he's having sex with someone other than his wife.
b) I'd certainly like to see this story made but not in a manner glorifying mercenaries, and Pinkerton's actions during the beginnings of the labor movement are horrendous.
c) Exactly how many people take credit for "co-creating" 24?
In some ways, this is like doing a series about the KKK. Some people might take offense especially since they will be glorifying them as opposed to doing a historical piece that would include warts and all.
Love the idea, but as people have stated their was as much bad done by the Pinkertons as good esp. after Pinkerton's death. Edison used them to spy on, harass and steal from inventors seeking patents he was after. It's even rumored they killed Louis LaPrince for the movie camera and projector he invented, before Edison.
I second labor history's comment. In the late 1800s/early 1900s, the Pinkerton Detective agency were absolutely brutal to workers that "dared" to unionize.
Bob & Angela are both wonderful people & writer/producers. STARZ/C. Albrecht are certainly building a reputation for quality material. This is excellent news. Congratulations to everyone involved.
Gerard Butler decided to be an executive producer, but did he turned down the role as Pinkerton, the Scottish? Good for you, Gerry is becoming more diversified in all areas of producing/creating movies beside acting.
A studio buying a project that glorifies the union-busting Pinkertons, in a contract year? I'm shocked
Gerry is becoming quite a business man. There are other ways to make money than acting. He is showing that he is not just a pretty face.
We have all been privy to Butler's production chops in "Law Abiding Citizen". We know he is a
very capable producer. I also agree that it would
be a great project for him to star in, if his schedule allows for his producing, maybe it will
also allow for him acting in the project.
I, like so many others, hope he takes this
project for producing and acting.
Even better, make it into a Steampunk piece! Then you'd have "The Wild Wild West" though, wouldn't you? (almost, anyway). If Gerard Butler doesn't star, forget about it. Though interesting history, without a compelling lead this is not going to work. But boy, will it ever look good and if it concentrates on the exciting derring-do and avoids the mercenary episodes in Pinkerton's career it could be very watchable. Make it very exciting!
Please, please, please Gerry, star in the Pinkerton series. I, and all your fans want to SEE you ON the screen, not just behind the scene.


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Edward N. "Skip" White, 61, of Carrollton, died Thursday, July 10, 2008, at his home.
Mr. White was born Aug. 15, 1946, in Brunswick, the son of Victor G. and Melvina L. (Underwood) White. He married Donna S. Hedrick of Carrollton on March 31, 1966; she survives of the home.
Additional survivors include: two sons and one daughter-in-law, John White and his wife, Toni, of Brunswick, and Ryan White and Jessica Goetting of Carrollton; two daughters and sons-in-law, Amy Tunnell and her husband, Reed, of Carrollton and Tiffany O'Neal and her husband, Clifton, of Carrollton; one brother and sister-in-law, Jerry White and his wife, Laura Lou, of Brunswick; one sister and brother-in-law, Betty Jane Sims and her husband, Jerry, of Brunswick; and 10 grandchildren, Cody White, Lucinda Tunnell, Presley Tunnell, Levi White, Kylie Self, Keaten O'Neal, Korbin O'Neal, Cami Jo White, Griffin O'Neal and Harley White.
In addition to his parents, two brothers, Wendall and George Willam White, preceded him in death.
Memorial contributions may be made to the family's choice.
Visitation was held from 10 to 11 a.m., Monday, July 14, at the First Assembly of God Church in Carrollton. Graveside services immediately followed the visitation at 11 a.m., at Carroll Memory Gardens Cemetery in Carrollton.
Arrangements were under the direction of Thurman Funeral Home in Norborne.
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Mega-retailer Wal-Mart is looking to take away a chunk of the money-transfer sector dominated by Western Union and MoneyGram.
The company has launched a new program called Walmart-2-Walmart Money Transfer Service that allows customers to transfer money to and from the more than 4,000 Wal-Mart stores in the U.S.
The company says its fees for the transfer will be "up to 50 percent less than similar offerings on the market."
"After listening to our customers complain about the high fees and confusion associated with transferring money, we knew there had to be a solution," Daniel Eckert, senior vice president of services for Wal-Mart U.S., says in a statement.
The company will allow domestic money transfers only. It allows for transfers of up to $900. It will charge a $4.50 fee for transfers of $50 or less and a $9.50 fee for transfers that are more than $50.
Wal-Mart says it is targeting the underbanked and unbanked, many of whom are probably Wal-Mart shoppers.
Shares of Western Union and MoneyGram International both fell in early morning trading Thursday on Wal-Mart's news.
Other companies getting into the finance sector
Wal-Mart isn't the only nonbank company working to push its way into the financial services and payments industry.
For instance, Facebook is reportedly close to gaining regulatory approval in Ireland for an online payment service, according to the Financial Times.
And cellphone carrier T-Mobile earlier this year got into the checking business by offering a prepaid Visa card, access to 42,000 ATMs and an app that customers can use to deposit checks.
Wal-Mart has had its eye on the payments industry for a while. It already has the Bluebird prepaid card and "offers other everyday money services such as check cashing, bill pay, money orders and tax preparation services," the company said in its press release.
What do you think of Wal-Mart's decision to offer money transfers? Will you use it?
Follow me on Twitter: @allisonsross.


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CrewsHair Stylist Male New York, New York, US
My Website: crewshair360
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"Build your dreams and your dreams will build you."
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I'm Crews, (yes, that's my real last name), -- a hair stylist that is always looking to work with cool, creative photographers, make up artists and stylists.
I'm continually blown away and inspired by the talent and creative genius in our industry and am humble enough to know that testing, studying, and practicing are things that I will always have to do to keep my skills sharpened.
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Unlike what some people call a "retirement home," Country Meadows of South Hills of Pittsburgh, Pa., provides multiple levels of care. Our full range of senior services in Pittsburgh include Independent Living, Personal Care, Memory Support Services and Restorative Services. This way, we can support residents in their current life stage and can continue to care for them if and when their needs should change.
Recognized as one of the best retirement communities in Pennsylvania, we are an all-rental senior living community in the Pittsburgh area with no buy-in, offering a spectrum of services where residents have an extraordinary opportunity to enjoy life to the fullest. Visit to see for yourself.
If your family is exploring retirement communities, we hope you will discover we are so much more. Though Country Meadows of South Hills of Pittsburgh is a unique retirement community, click here for what residents and families can always expect of our resident-centered care and programs at any Country Meadows.
Let us show you how we differ from what you may expect in a retirement community. We've helped many families feel at home. We'd love to welcome yours. We hope to see you soon.
Pittsburgh: the Steel City, a strong community. If you appreciate community, then you'll appreciate us. We're located in the beautiful South Hills area of Pittsburgh—a suburban area with shops, theaters, churches and restaurants. Set on 23 acres in Bridgeville within South Fayette Township, our campus is easy to reach via Interstate 79 and close to communities like Upper St. Clair, Mt. Lebanon, Peter's Township, Canonsburg and Meadowlands. Pittsburgh is just a short drive away.
New to the area? How exciting! Pittsburgh has been voted among the best places to retire for its low cost of living, high quality of health care and support of overall well-being. We recommend visiting these websites for more city insights and reasons to enjoy Pittsburgh.


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The Digital Workplace: Designing Groupware Platforms (Vnr Computer Library)
Forward-looking managers and executives will consult this guide for timely advice and practical guidance on integrating today's most advanced communication technologies into their core business operations. Here are all the proven strategies readers need to design, develop and implement new software platforms that integrate work teams and distributed organizations and promote enhanced productivity.
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Home > Wellness > Health Library > Benzodiazepines
Browse and register for related classes.
Benzodiazepine medicines are used to relieve anxiety, induce
sleep, relax muscles, and relieve muscle spasms or seizures. Benzodiazepines
work by slowing down the central nervous system.
Benzodiazepines can be habit-forming and are sometimes used
illegally. Frequent or high-dosage use of benzodiazepines can lead to abnormal
behavior (such as aggression and hostility) and to dependence on the
Common benzodiazepine medicines include alprazolam (Xanax),
chlordiazepoxide (Librium), diazepam (Valium), lorazepam (Ativan), and oxazepam
Current as of:
July 26, 2016
Healthwise Staff
Medical Review:
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My father's skin was quite dark, but it still couldn't hide the scars on the bridge of his nose and on his brow. He had big eyes with long lashes, but the whites of his eyes were yellow. Acquaintances said he had problem with his liver. They were right.
My father's liver was gradually eroded during his life-long battle with alcohol.
I don't know when and where my father took his first sip of alcohol or what drink it was. My mother told me the drinking started from the late 1970s, when he was left in Shanghai by his parents, who came to Hong Kong for a better life.
Without the guidance of his parents, my teenage father dropped out of school in the aftermath of the Cultural Revolution. He just drifted in society.
He was rich and rather trendy then, thanks to the money and clothes sent by his parents from Hong Kong. Wearing his long hair, with a pair of large sunglasses and well-tailored floral-pattern shirts, he strutted proudly on the streets. Sometimes, he carried a transistor radio - like a child showing off a new toy.
At night, he and his friends flocked to restaurants, eating, drinking, talking and flirting with girls - having fun and sometimes a drunken fight. My mother said my father's favourite drink was Baijiu - the Chinese distilled liquor which generally contains over 50 per cent ethanol. He could drink half of a bottle at a time. His drinking abilities were envied by his friends.
I don't know much about my father's relationship with alcohol before I was born, but I do know about it afterwards. When I was 10 years old, my mother divorced my father because of his poverty and violence after he had been drinking. My father tried hard to take care of me and my sister, although he did not have a job. During the day, he was sober and cooked for us. But when the sun went down, my father would become trapped in a world of darkness.
In our narrow half-underground apartment, the air was so humid that mushrooms could grow. In the dim light, my father sat at the corner, against the old furniture he bought with my mother when they got married. He used a plastic cup filled with cheap rice wine. Alone, he would sip from the cup. The 21-inch television would be on and my father would begin to murmur. He was alone, although he had an invisible friend – a bottle of alcohol. I could hear my father talking to the bottle - discussing his glorious past, his unfaithful wife, his careless children and his inability to cope life.
"Alcoholics use alcohol in an attempt to make peace with their sense of the relationship between past, present, and future," Norman Denzin wrote in his book The Alcoholic Self.
I try to use the books on alcoholics to understand my father, but I find I can never fully comprehend him. I am like lots of other children who can never completely understand their parents either. What I do know is emptiness engulfed him; he could never escape, so he could never stop trying to escape through alcohol.
I moved out of my father's apartment after I graduated from university. I wanted to live independently and escape his despair.
Last March, I got a call from my mother, saying my father was in hospital. I was not surprised, because he had fallen and been injured after drinking several times, leaving many scars. But I had not realised the seriousness of his condition until I went to the hospital. He had a cerebral haemorrhage.
The main blood vessel had exploded in my father's brain, damaging 80 per cent of it. His chronic alcoholism had caused hypertension, which brought on an unexpected cerebral haemorrhage. The doctor said my father had died because his brain stopped functioning, but his heart still worked because of the drugs he had been given. Over the next three days, his organs died one by one: lungs, liver and kidneys. We watched the cardiograph fluctuating. Then my father passed away.
It made me question many of the things that had happened during his life. If only my grandparents hadn't left my father? If only he hadn't dropped out of school after the Cultural Revolution? If only he had had more job opportunities? If only he had been more positive about life? If only we had communicated with him more? If only we had realised alcoholism was so serious? If only there were more organisations treating alcoholism? If only there were better policies to restrict alcohol consumption and sales in China? My father's life could have turned out differently. And many Chinese people who have also died from alcoholism could have been saved.
Last June, we found a good place to lay my dad to rest. We buried him in a peaceful countryside. I poured some Baijiu in front of his grave.


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The European Commission has adopted an ambitious Road Safety Programme which aims to cut road deaths in Europe in half in the next decade. The programme sets out a mix of initiatives, at European and national level, focussing on improving vehicle safety, the safety of infrastructure and road users' behaviour.
Much work has already been done in the period 2001-2010 with regard to "passive" safety devices for vehicles such as seatbelts and airbags. Between 2011-2020 a range of new "active safety" measures will come into force for safety equipment including:
*Mandatory electronic stability control (for cars, buses and trucks to reduce the risk of destabilising or rolling)
*Mandatory lane departure warning systems (for trucks and buses)
*Mandatory automatic emergency braking systems (for trucks and buses),
*Mandatory seat belt reminders (cars and trucks)
*Mandatory speed limiters for light commercial vehicles/vans (already in place for trucks)
*For electric vehicles, the Commission will bring forward a package of concrete measures setting technical standards for safety.
*The Commission will examine the possibility of extending the implementation of advanced Driver Assistance Systems, such as anti- collision warnings by retrofitting them to commercial and or private vehicles.


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Advent Calendar
My husband's mom has a really cool advent calendar. She made it from a Busilla kit when her kids were babies (they're both in their 40s now). Dave said he wanted that advent calendar when she died (she encourages us to tell her what we want when she dies), but I knew that his sister would want it as well. I actually thought that she'd somehow snagged it last year when she said she had it, but it turned out my mother-in-law had only loaned it to her. When Dave's mom dies (hopefully not for 30 or more years — that would put her over 100), I don't want to start any wars or bad feelings over any thing. Material possessions are not worth losing family over, so I decided to make an advent calendar myself!
My inspiration started over at homemade by jill. She did an advent sew along that has great instructions, some tutorials, but best of all, a LOT of pictures from people who did the advent sew along. Here's her instructions:
Week 1
Week 2
Week 3
Week 4
Brief discussion on what kind of felt to use
Ornament templates
I scoured Jill's Flickr group to see what ornaments people had made. I needed inspiration for colors, details, and unique ornaments. I wanted this advent calendar to be special to my family, which is why we had to have a football. Football is a big part of our family and part of the Christmas tradition, so that was a must. If I could avoid it, I didn't want to have any duplicates such as ornaments or presents.
I started on this project back in February so there wouldn't be any pressure to finish it at the last minute. I purchased felt from Heather Bailey and got to work on the ornaments. All of the ornaments are hand stitched and stuffed, even the candle.
This was my biggest advent calendar inspiration! I copied the shape of her tree and really made an effort with my ornaments. I wasn't going to machine stitch them, but if something wasn't as close to perfect as I could get it, I did it again.
Inspiration for the acorn and the color of the pockets came from Jeanetics, Rudolph is from See Suzy Spin (and despite the fact that she says the wreath is super easy to make, I couldn't do it and am bummed. Her wreath is super cute!), and the tilted hat on the snowman was inspired by this one. I made the sleigh from a picture I found online, as well as the rocking horse (though there's a good template here). There's a few ornaments I want to redo, and since we're hoping to have another baby someday soon, I'll be making a stocking for the advent calendar for that child. I'd like to have a few extra ornaments, so if you have any suggestions, please let me know! I've tried and failed at making a wreath, holly is an option, but other than making another ornament or present, I'm at a loss. The nativity ornaments seem like an obvious choice, but my husband would rather not have them.
I realized after sewing on almost half the buttons that you really need a button with a shank. They do not make green buttons with shanks. Trust me, I googled the heck out of that question. You can make a shank, though, either with the thread that you use to sew on the button or with a bead. I found some green beads that seemed to be perfect, and I initially thought I would have just one bead in the center of the button, but I couldn't make the button sit correctly on the bead. I eventually figured out that I could have one bead under each hole, not only giving the beads the perfect lift off the felt, but also allowing them to sit just right. Bonus: they add a little bit of sparkle of you happen to be looking at the calendar from the side!
The snowflakes and the candy cane bias tape were my husband's idea, both of which I balked at and have since become my favorite parts of the calendar. The snowflakes add some interesting dimension to areas that would otherwise be bare, and the candy cane striping makes the calendar so much fun! Unfortunately, I wasn't able to find red and white striped bias tape. I don't know if it's a seasonal thing or if it even exists. What I found was on Etsy and was handmade by someone. I ended up needing about 3.5 yards of the bias tape, which I only found out after I bought 3 yards of vintage red and white striped bias tape. The tape that is on the calendar now is what was handmade and was bought after I got the vintage tape and realized I didn't have enough.
Binding the back and front together took more skill than I currently have, so I owe a huge thanks to Amanda for helping me out with it. She patiently sewed the two pieces together when I was afraid to and never made me feel like I was intruding, even though I was there for 6 hours, 4 of which was spent finishing the advent calendar.
As part of the advent calendar, I want to make a tradition of having things we do in the days leading up to Christmas. I want it to be a time of year that we not only slow down and enjoy time as a family, but that we focus on being thankful and kind to others. I thought about having activities in each pocket, but what if you can't do the activity that day? So instead I will have a list of things to do that will go in the pocket on the day that we do them. Things like, "Enjoy mugs of hot chocolate in front of the fire." "Find the home with the best Christmas lights and take them a thank you note." That last one is from here, which really inspired me! It's not just about enjoying the Christmas lights because you thank the people that put up your favorite display. How kind and thoughtful! Maybe one will be, "Open the door for everyone today." Nothing monumental, but something that takes us outside of ourselves. I haven't made up my full list, but I will soon! More inspiration for activities can be found here.


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Medical Definition of Natriuresis
Natriuresis: The excretion of an excessively large amount of sodium in the urine. Natriuresis is similar to diuresis (the excretion of an unusually large quantity of urine), except that in natriuresis the urine is exceptionally salty. Natriuresis occurs with some diuretics and diseases (as of the adrenal) and can lead to the salt-losing syndrome characterized by dehydration, vomiting, low blood pressure, and the risk of sudden death.
Natriuresis is a ancient language hybrid of the Latin natrium = sodium and the Greek ouresis = a making water.
Last Editorial Review: 5/13/2016
Back to MedTerms online medical dictionary A-Z List
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Diagonal Square Pillow by Patons
Welcome! You are browsing as a guestWould you like to see 3 projects made from this pattern and much more? create a free account What am I missing?
© Patons
Diagonal Square Pillow
This pattern is available for free.
This dynamic pillow is worked from different angles and looks particularly good in variegated shades. Shown in Patons Decor. (Patons Yarns)
Skill Level: Easy
Patons® Decor (100 g/3.5 oz)
5 balls
Size 4½ mm (U.S. 7) knitting needles or size needed to obtain tension. One 18 ins 45.5 cm square pillow form.
19 sts and 38 rows = 4 ins [10 cm] in stocking st.
One square = 9 ins [23 cm]
Make 8 squares.
Finishing: Sew 4 squares together to form large square. Sew 3 side seams. Insert pillow form. Sew remaining seam. Sew pom-pom to center of cushion.
Pom-pom diagram is provided in pdf download (May 2009).
For more information, see: http://www.yarnspirations.com/pattern/knitting/diago...


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Family-Centered Diabetes Project
This study has been completed.
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Information provided by:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ClinicalTrials.gov Identifier:
First received: August 8, 2000
Last updated: February 12, 2010
Last verified: February 2010
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
The purpose of this project is to determine whether a diabetes lifestyle program will improve the lives of Native American people living with diabetes. We recruited Native American people living in 8 Pueblo communities served by 3 Indian Health Service clinics. Forty percent of people living with diabetes in those communities participated in an interview and had height, weight, blood pressure and hemoglobin A1c measured at the beginning. Then they received a lifestyle program in either groups or one-on-one, or another group which got the intervention after one year (comparison group). The program was developed using input from community members, tribal leaders, and clinic staff, and was taught by community members in or near the participating communities. After each session, participants were asked for feedback about the curriculum. After the program ended, the interview and clinical measures were repeated. Feedback to tribal leaders and clinical staff is ongoing.
|Behavioral: lifestyle (exercise, diet, and family and community support)
|Study Type:
|Study Design:
|Primary Purpose: Treatment
|Official Title:
|Family-Centered Diabetes Project for Pueblo Native Americans
Further study details as provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
|Ages Eligible for Study:
|18 Years and older (Adult, Senior)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Male or female 18 years or older with diabetes living in a participating Native American community served by one of three participating Indian Health Service clinics.
Exclusion Criteria:
- Unable to complete a yearly interviewer administered questionnaire and clinical measures of height, weight, blood pressure, and fingerstick hemoglobin A1c.
- Unable to participate in 5 lifestyle intervention meetings occurring over a one year period.
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00006159
Please refer to this study by its ClinicalTrials.gov identifier: NCT00006159
|United States, New Mexico
|University of New Mexico School of Medicine
|Albuquerque, New Mexico, United States, 87131
Sponsors and Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|Principal Investigator:
|Janette S. Carter, MD
|University of New Mexico School of Medicine
More Information
Additional Information:
Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on August 22, 2017
Additional Information:
The intervention curricula, Strong in Body and Spirit! (participant version) is located at this web site and may be downloaded.
Gilliland SS, Carter JS, Perez GE, Two Feathers J, Kenui CK, Mau MK. Recommendations for development and adaptation of culturally competent community health interventions in minority populations with Type 2 diabetes mellitus. Diabetes Spectrum 11:166-174, 1998.
McFee T, Cunningham-Sabo LD, Perez GE, Gilliland SS, Carter JS. A feast day poster: Healthful and successful modification of holiday foods. J Nutr Educ 29:356B, 1997. (two page ''GEM'' article)
Stolarczyk LM, Gilliland SS, Lium DJ, Owen CL, Perez GE, Kriska AM, Ainsworth BE, Carter JS. Knowledge, attitudes and behaviors related to physical activity among Native Americans with diabetes. Ethn Dis. 1999 Winter;9(1):59-69.
Carter JS, Pugh JA, Monterrosa A. Non-insulin-dependent diabetes mellitus in minorities in the United States. Ann Intern Med. 1996 Aug 1;125(3):221-32.
Carter JS, Wiggins CL, Becker TM, Key CR, Samet JM. Diabetes mortality among New Mexico's American Indian, Hispanic, and non-Hispanic white populations, 1958-1987. Diabetes Care. 1993 Jan;16(1):306-9.
Carter J, Horowitz R, Wilson R, Sava S, Sinnock P, Gohdes D. Tribal differences in diabetes: prevalence among American Indians in New Mexico. Public Health Rep. 1989 Nov-Dec;104(6):665-9.
Carter JS, Gilliland SS, Perez GE, Skipper B, Gilliland FD. Public health and clinical implications of high hemoglobin A1c levels and weight in younger adult Native American people with diabetes. Arch Intern Med. 2000 Dec 11-25;160(22):3471-6.
Griffin JA, Gilliland SS, Perez G, Helitzer D, Carter JS. Participant satisfaction with a culturally appropriate diabetes education program: the Native American Diabetes Project. Diabetes Educ. 1999 May-Jun;25(3):351-63.
Griffin JA, Gilliland SS, Perez G, Upson D, Carter JS. Challenges to participating in a lifestyle intervention program: the Native American Diabetes Project. Diabetes Educ. 2000 Jul-Aug;26(4):681-9.
Carter JS, Perez GE, Gilliland SS. Communicating through stories: experience of the Native American Diabetes Project. Diabetes Educ. 1999 Mar-Apr;25(2):179-88.
Gilliland SS, Willmer AJ, McCalman R, Davis SM, Hickey ME, Perez GE, Owen CL, Carter JS. Adaptation of the Dartmouth COOP Charts for use among American Indian people with diabetes. Diabetes Care. 1998 May;21(5):770-6.
Carter JS, Houston CA, Gilliland SS, Perez GE, Owen CL, Pathak DR, Little RR. Rapid HbA1c testing in a community setting. Diabetes Care. 1996 Jul;19(7):764-7.
Gilliland FD, Owen C, Gilliland SS, Carter JS. Temporal trends in diabetes mortality among American Indians and Hispanics in New Mexico: birth cohort and period effects. Am J Epidemiol. 1997 Mar 1;145(5):422-31.
|ClinicalTrials.gov Identifier:
|NCT00006159 History of Changes
|Other Study ID Numbers:
carterj (completed)
R01DK047096 ( U.S. NIH Grant/Contract )
|Study First Received:
|August 8, 2000
|Last Updated:
|February 12, 2010
Keywords provided by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK):
lifestyle intervention
Native American
community intervention
Additional relevant MeSH terms:
Diabetes Mellitus
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
ClinicalTrials.gov processed this record on August 22, 2017


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New Zealand Post has increased its stake in electronic business-to-business service provider the Electronic Commerce Network (ECN) from 60 per cent to 100 per cent for an undisclosed figure.
ECN allows businesses to share data irrespective of the software they are running.
The company has around 750,000 messages passing through its switch every month.


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Escapee who stabbed detective in Texas vows not to go back to prison
GRAPEVINE, Texas — The Florida prisoner who stabbed a detective and escaped near Dallas while being transported to Nevada is "a schizophrenic" who vowed not to return to prison, according to authorities and a 911 call released on Wednesday.
Alberto Morales, 42, escaped on Monday by using a piece from his eyeglasses to stab Miami-Dade Detective Jaime Pardinas, one of two officers transferring the prisoner by car to Nevada. The escape happened while they were stopped in a Wal-Mart store parking lot in Grapevine, a community near the Dallas-Fort Worth International Airport.
Grapevine police spokesman Robert Eberling said authorities continue to search near the airport and will do so until they believe they should look elsewhere. He said the search covers "any place anybody can hide," including yards and drainage ditches.
Eberling said inmates who knew Morales in prison have told investigators that he had vowed not to return.
"He's made it pretty clear that he's not going back to prison," Eberling said.
On a recording of a 911 call released Wednesday, Pardinas can be heard breathing heavily as he tells the operator that he's been stabbed. He described Morales' height, weight and appearance and then added, "He's a schizophrenic."
On another 911 call, a bystander told the operator: "There's a guy with a gun and somebody on the floor bleeding." The caller than clarified that "the guy with the gun is helping the guy that's bleeding."
Pardinas, 54, remained hospitalized Wednesday after undergoing surgery for deep stab wounds to the neck, shoulder and back and a collapsed lung, said Miami-Dade police Sgt. Patricia Bimonte.


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Did you like this post? Visit a popular post on Why I Wear Skirts All The Time or a tutorial for a quick but elegant hairstyle. Also, please come join me on Facebook I'd love to chat with you there!
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November 22, 2012 by · Leave a Comment


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Have you tried this recipe? Let us know what you think! Share your feedback with the Jetboil community.
When hot chocolate takes 30 seconds to make, you might start drinking a lot more of it. We won't hold it against you if you buy the packets of Swiss Miss or Carnation, but here's a good recipe if you're a diehard do-it-yourselfer.
Ingredients:1/3 cup cocoa1 1/3 cup instant nonfat dry milk1/2 cup sugar2 tablespoons powdered non-dairy creamer1/4 teaspoon saltOptional: instant coffee
Mix all ingredients and store in a zip lock baggie.
To one cup hot water, add 1/3 cup dry mix (about four to six heaping tablespoons) and stir well. Add a little instant coffee for mocha. Life is good.


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Type of Document Master's Thesis Author Culli, Daniel R. Author's Email Address firstname.lastname@example.com URN etd-06032004-112424 Title "Never Could Read No Road Map": Geographic Perspectives on the Grateful Dead Degree Master of Science (M.S.) Department Geography & Anthropology Advisory Committee
Advisor Name Title Kent Mathewson Committee Chair Andrew Curtis Committee Member Craig Colten Committee Member Keywords
- music geography
- acid rock
- san francsico
- carnivalism
- carnivalesque
- grateful dead
Date of Defense 2004-03-25 Availability unrestricted AbstractThe Grateful Dead hold a unique niche in the musical, social, and cultural history of the United States. However, while the volume of available academic literature concerning the band is increasing, the Grateful Dead remain to be nearly ignored by academia and, to this point apparently, completely ignored by cultural geographers. This paper introduces the Grateful Dead into the field of geography. I analyze the geography of certain aspects of the band, such as its context in San Francisco, the carnival atmosphere of the entire phenomenon, the over 2300 tour dates, as well as the huge catalog of lyrics sung by the band throughout their thirty year career. I intend this thesis to serve as an introduction to geographic research of the Grateful Dead phenomenon as well as a basis for further geographic research of it, offering some ideas for further research in the final chapter. Files
Filename Size Approximate Download Time (Hours:Minutes:Seconds)
28.8 Modem 56K Modem ISDN (64 Kb) ISDN (128 Kb) Higher-speed Access Culli_thesis.pdf 1.32 Mb 00:06:05 00:03:08 00:02:44 00:01:22 00:00:07
If you have questions or technical problems, please Contact LSU-ETD Support.


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Check Availability
Gift options are limited due to availability on the date requested. You may wish to consider a different delivery date for a broader selection.
Happy Kwanzaa! A time for African-Americans to celebrate and embrace their heritage and culture, reaffirming all that has come to be and all that is yet to come with seven days of festivities. Choose from our selection of beautiful flowers, gorgeous and full plants, and gourmet treats.
Shipped Farm Fresh in a Gift Box Sun-Drenched Summer Rose Bouquet - VASE INCLUDED
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Wonder Woman (not Batman) is real star of 'Justice...
How the Warriors are spending their championship offseason
California's lesser-known wine hotspot was named best small...
Trump Calls Peaceful Boston Protesters 'Agitators'
'Free speech rally' cut short after massive counterprotest
Traffic nightmare hits Oregon leading up to eclipse (photos)
Body of white shark, likely struck by boat, vandalized after...
Evacuation orders affect hundreds in California, Oregon
These 52 celebrities don't drink alcohol
Kevin Durant trades barbs with fired ESPN reporter Britt...
Monthly Archive for January, 2014
The Long Lost David Mamet Interview, from 1994
Note: In November, 1994, I did a telephone interview with David Mamet. Fifteen minutes after I finished writing up the interview, the San Francisco Chronicle went on strike, and so the article never …
Peter Cowie on Satyajit Ray
Here is the latest in Peter Cowie's Flashback series. This one is about Satyajit Ray. …
American Cool
On February 7, the National Portrait Gallery in Washington, D.C. is launching an exhibition called "Americoan Cool," which will explore the definitions of cool and offer examples of it, through …
Replay: Jane Pauley Leaves the Today Show, October 27, 1989
I have never been an early riser. Left to my own devices, I'm almost never up before 8:30 and usually not before 9. But for some reason on October 27, 1989, I was up early enough to witness the above …
50 Years Since 'Dr. Strangelove'
Every year — or most years — if we're lucky, it's every year — there's what I like to call The Thing That Happened in Cinema. It's the movie that does something different, that pushes the art form …
Gallery of the Under-rated 2014
It's the time of the year to honor the Underrated. The above gallery contains selections by me and by readers, and feel free to add to it. It's an opportunity to call attention to some good work …
Replay: Ringo Starr at the Shoreline
Ringo Starr brought his All-Starr Band to the Shoreline in the summer of 1989, and I reviewed it. Here's what appeared in the paper two days later: Ringo Starr, a performer everyone likes but …
Replay: Sheena Easton at the Shoreline, 1989
Note: Sheena Easton was a pop star of the 1980s. We didn't know it at the time, but this tour probably marked the end of her ten years or so of popularity, though perhaps there were hints of that in …
Replay: Red Skelton at the Circle Star, 1989
This was one of the more unexpected shows I've ever seen. Red Skelton was appearing at the Circle Star Theater, doing a long standup act, and I went, figuring it would be OK, kind of old-fashioned, …
Replay: Billy Joel in April, 1990
Every so often, usually by accident, I run into something on my computer from the days before we went electronic that I think somebody somewhere conceivably might possibly might want to read …


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About Us
Mark Nicolini,C.H.A
Mr. Nicolini is a dynamic hotel and corporate housing professional. He possesses over twenty five years of Hotel, Food & Beverage, and Corporate Housing experience. He brings the quality and customer service of a 5-Star hotel experience to the world of temporary, serviced apartments. "Hospitality" is his key.
In the late 1980's Mr. Nicolini seized the opportunity to train in Japan in preparation for the 1988 Seoul Olympic as a member of the U.S. Judo Team. He lived in Japan for six years and learned much about the art of Zen.
His career highlights include the formation, management, and operation of Guardian Property Management SA de CV, consisting of a management and operation portfolio of three condo-hotel resorts, four restaurants, and five bars on the oceanfront in Cancun, Mexico.
Returning to the United States in early 2001, Mr. Nicolini joined prestigious Accor Hotels, where he was awarded Accor North America General Manager of the Year in 2004. He later moved to a position with Woodfin Hotels and Suites as the East Coast Regional Director of Operations. Most recently, Mr. Nicolini served as the General Manager of the Greater Washington D.C. market for a major world-wide serviced apartment, corporate housing provider.


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Thanksgiving with Celebrities: Past and Present (PHOTOS)
It's that time of year again! The holiday season is underway with Thanksgiving just days away. And what better way to spend Turkey Day than with your favorite stars.
Some celebrities like Hilary Duff and Alyssa Milano have celebrated at the Annual Macy's Thanksgiving Day Parade while others, such as Mariah Carey and Stephanie Pratt give back to their communities and serve meals to the less fortunate. And this year wCelebuzz has all the scoop on what your faves like Miley Cyrus, Beyonce and even Demi Lovato have planned.
Click through the gallery to find out how celebrities give thanks and where they reflect on what they are most grateful for.
Happy Thanksgiving!


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Travel in Rajasthan, India: The Lake Palace in Udaipur
Second stop: The City of Lakes
Founded in 1567 by Maharana Udai Singh on the advice of a sage, Udaipur was the last of the Mewar capitals. Its romance and intrigue are almost mythical, the enduring source of inspiration for poets and artists. (And, um, this was the setting for that James Bond flick, Octopussy.) Surrounded by mountainous terrain, situated next to three lakes-- Pichola, Fateh Sagar and Udai Sagar—the city is like an oasis in the desert. The maze of narrow streets are lined by colorful markets, temples and gardens exploding with color. Set on a hill along the shores of Lake Pichola, the white City Palace seems to soar above the city. Enter through the Elephant Gate, wander the courts with carved arches, through pavilions and terraces with hanging gardens, and notice the blue tiles, inlaid mirrors, and miniature paintings depicting heroic historical scenes. Head to the markets for excellent shopping: pick up a few of the engraved miniature paintings depicting historic battles and epics, and leather books made with handmade paper (pressed with dried flowers).
Udaipur's Lake Palace is one of the most romantic spots in the world. It appears like a brightly lit castle floating on water. Though when we visited last year, Rajasthan was suffering a serious drought, so the lake had dried up to nothing. We walked along the treeless plain of the lake-bed and noticed the water buffalo navigating the emptiness. In the distance, women's saris appeared like billowing sails of color. The white marble palace seemed to be its own solitary island. And to think-- this 250-year old palace has been transformed into a magical luxury hotel. The Taj Lake Palace was originally built as a summer residence, designed with marble pillars, elaborate glasswork, colorful murals, and all the sumptuous details of a royal residence. Rooms offer stunning views of the Lake and Aravali mountain range. The Grand Royal Suites offer Jacuzzi tubs, marble bathrooms with rainforest showers, beautifully detailed artwork and crystal chandeliers.
The Taj Lake Palace, Official Site
The Taj Lake Palace, Five Star Alliance
Banyan Tree Bangkok
Sathon, Thailand
In this sprawling metropolis, Banyan Tree Bangkok stands out as a much-needed 'sanctuary for the senses' and a rejuvenating spa retreat. The Only All-suite Hotel, Banyan Tree Bangkok is situated in the heart of the Bangkok's... more >>
Banyan Tree Bintan
Bintan Island, Indonesia
Hike in a rainforest teeming with giant trees and lush life, hillside terrain, secluded beaches and the sweet song of birdlife. Immerse yourself in a natural sojourn on Bintan island. Banyan Tree Bintan delivers views of the... more >>
Banyan Tree Phuket
Cherngtalay, Thailand
An island paradise of golden sunsets and perfect moments, Phuket offers fine beaches, turquoise seas and warm sunny weather. Discover the romance and beauty of this island with Banyan Tree Phuket. This is a destination that... more >>
Sofitel Angkor Phokeethra Golf and Spa Resort
Siem Reap Province, Cambodia
Sofitel Angkor Phokeethra offers five-star accommodations close to the magnificent Angkor Wat, World Heritage. Experience this luxury resort - consistently rated as one of the best Siem Reap hotels - which combines between Khmer... more >>
Sofitel Legend Metropole Hanoi
Hanoi, Vietnam
A proud prominent feature at the heart of Hanoi since 1901, the French colonial style Sofitel Legend Metropole Hanoi has a long tradition of welcoming playwrights, ambassadors and heads of state, a luxury place for many... more >>


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Rye beat Ardsley 62-39 this afternoon at Ardsley High School in a game emblematic of the Garnets' season. Today, their inconsistency played out in the span of one game. They led 21-4 early, allowed a 10-0 run and erupted for 25 points in the third quarter.
It was just another ho-hum night for Rye, which is a threat in Class A if it can ever deliver for 32 minutes against a quality opponent. Max Twyman, the three Mikes (Garofalo, O'Neill, and D'Antoni) and Andrew Livingston can all score. That's a dangerous group whenever shots are falling.
Here's my game story on Rye and its victory today:
ARDSLEY After a strong weekend earned it Mamaroneck's Sound Shore Classic title, Rye visited Ardsley to confront its greatest adversary: itself.
The up-and-down Garnets, who seem in constant pursuit of greater consistency, quickly found themselves chasing it again. A sluggish second quarter irked coach John Aguilar, who, despite a comfortable lead, told his team comfortable wasn't good enough.
"There was some yelling, but it was more just telling the boys that if we're going to be that Class A team that's one of the contenders, we need to step it up and show it in the third quarter," Aguilar said.
Indeed, the Garnets erupted for 25 points to take control and went on to beat Ardsley 62-39 Tuesday night.
Max Twyman (pictured right) finished with a game-high 16 points and eight rebounds. Mike O'Neill added 15 points and sank three of Rye's 10 3-pointers.
"We're trying to be more consistent," said Twyman. "We're trying to have hard practices every practice and not take possessions off. That's been our weakness, taking plays off."
The Garnets were on early and led 21-4 before they fell into a lull the last five minutes of the half. Ardsley's Gabe Kardish (13 points) scored to spark a 10-4 Panthers run that was only quieted by Twyman's tough 3 to end the half.
Point guard Mike Garofalo (pictured upper left, with Kardish) then keyed Rye's strong third-quarter surge. He facilitated the offense and found open shooters, finishing with 12 assists to go with seven points, six rebounds and four steals.
It propelled the Garnets (8-5) into next week, when they have rival Harrison and one-loss Byram Hills on the schedule.
"I definitely think there's no team that can beat us when we're on our game," Twyman said. "We just have to show that through the end of the season."
Pressure defense will be key. Rye forced 18 turnovers against Ardsley (3-11), almost all of them before Aguilar pulled the starters just inside the six-minute mark of the fourth quarter.
"We pride ourselves on being aggressive on defense, getting steals," Garofalo said. "We can't really rebound. That's one of our weaknesses because we don't really have a big man. We just work together. We enjoy playing with each other."
Ardsley victimized Rye's undersized front line for 13 offensive rebounds, but the offense continued to struggle. It has been especially quiet since starting point guard John Scrofani was lost for the season when he re-injured his knee over Christmas break.
"We're not going to dwell on it. We have a big week next week with Eastchester, Sleepy and Woodlands," first-year coach Josh Javer said. "If we can get one of those league games, we'll make sectionals. That's still a reachable goal."


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"Invensys Involved" Program Supports Local Communities
Organization Steps Up to Provide Bikes for Needy Kids in Houston, Student Mentoring in Massachusetts
By Keith Larson, VP Content
For Invensys Operations Management, the commitment to "support" extends well beyond its customers and products. Indeed, through the company's "Invensys Involved" program, Invensys and its employees support a broad range of education, health and safety, civic enrichment and environment causes.
"Since its inception, Invensys has been committed to supporting community-building activities in the locations where we operate," says Sudipta Bhattacharya, Invensys Operations Management CEO and president. "We understand that stronger, healthier and more vibrant communities provide better environments for us to conduct business and better places for our colleagues, customers and partners to live."
Invensys Involved is a corporate-wide community investment strategy intended to build and sustain relationships of trust. "Because we are growing and expanding our presence in numerous geographies and industries, our community involvement activities must make a positive impact in the wide variety of locations where we operate," Bhattacharya says.
Two recent examples of Invensys Involved making a positive impact in its communities include its support of Elves & More in Houston and Career Pathways in Foxboro, Mass.
In Houston, 100% of the ticket proceeds from Invensys Operations Management's annual employee appreciation party went to Elves & More, a non-profit organization that provides new bicycles to at-risk and impoverished children. With the donation, Elves & More supplied 100 bicycles and 100 helmets to students at Fondren Middle school. The team's commitment did not stop there; volunteers from Invensys Operations Management took part in building and delivering the bicycles.
"Thank you for your support," says Rebecca Roberts, Elves & More executive director. "Through your partnership, students signed contracts to improve academically in after-school programs and also achieved goals which they set with their teachers. Together we are changing lives—one bike at a time!"
Career Pathways, a program being piloted by a local high school in Foxboro, Mass., is designed to provide students an opportunity to work in fields of interest before entering the workforce or university. Students receive course credit along with performance reviews by their student mentor.
Invensys Operations Management has supported this initiative by providing positions in process engineering, precision machining and occupational health and safety. Students in the engineering track participated in design and process reviews, engineering support tasks and use of advanced applications. Students in the precision machining track worked with experienced machinists and operated state-of-the-art machining equipment. The occupational health and safety track provided students with exposure to workplace safety, medical monitoring and wellness strategies.
Based on positive feedback, Invensys Operations Management plans on expanding this program to include software development and hardware engineering in future years.
"We continue to help improve the quality of life in the communities in which we all live and work," Invensys' Bhattacharya says. "We're Invensys, and we're not standing on the sidelines. We're involved."
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Most people have rented a house or an apartment at some point in their lives. While it is fairly straightforward to get into a rental lease, it can be more challenging if a tenant (or a landlord) wants to get out of one—particularly if it's a long-term lease.
How Fixed-Term Leases End
Fixed-term leases obligate landlord and tenant to the entire lease term, typically one year.
A landlord may end a lease prematurely if the tenant violates the lease—for example by failing to pay rent or by damaging the rental property. But even if a landlord has a good reason for ending a lease early, he or she must comply with numerous state rules, procedures and forms for terminating the tenancy, filing an eviction lawsuit, and using the security deposit to cover any losses.
Unless the landlord agrees to cancel the lease, the tenant is legally obligated to pay rent for the entire lease term (with some exceptions—for example, if the landlord seriously violates the lease, such as by failing to provide habitable premises). Tenants have a way out in most states, however—and that's because most landlords have the legal duty to "mitigate damages" by trying to find a replacement tenant, rather than sitting back and collecting rent from the outgoing tenant.
How Month-to-Month Rental Agreements End
A month-to-month rental agreement provides more flexibility than a fixed-term lease. Under the laws of most states, a landlord or tenant can end a month-to-month rental agreement with a short amount of notice (typically 30 days).
Advice on Ending a Tenancy
Tenants who want more advice on notice required to end a tenancy, breaking a lease, and getting the security deposit back, should see Moving Out of a Rental.
Landlords who want more information, should see the Evicting a Tenant or Ending a Lease section of Nolo.com, especially the Terminating a Lease or Rental Agreement FAQ.
Getting Help from a Landlord-Tenant Lawyer
The law surrounding the early ending of a residential lease can be complicated for both landlords and tenants, especially if the tenant does not want to move out or if the landlord doesn't want the tenant to leave. Plus, the facts of each case are unique. This article provides a brief, general introduction to the topic of how leases and rental agreements end. For more detailed, specific information, please contact a landlord-tenant lawyer.
Questions for Your Attorney
- I'm renting out my condo for the first time, and may need to move back in a few months. What language should I include in my lease to give me this flexibility?
- My tenant just moved out with five months left on his lease. I'm having a difficult time finding a new tenant. I expect the old tenant to pay rent until I find a new tenant. He says he won't. How can I collect?
- One of my tenants is really difficult to deal with. He pays rent on time, but he's unpleasant to me and other tenants in the building. Unfortunately, he has seven months left on his lease. Is there a way I can (legally) get him to leave early?


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The Veteran & Military Center provides a new Veteran Student Orientation before the start of each term (Fall, Spring, Summer). This orientation is open to all veterans and military-connected service members who are new or transfer students to assist with bridging the gap between the military and campus culture.
New students are emailed details of the orientation upon admission to Wright State University. Orientations are held in August, January and May.
Topics covered at orientation include: transition from military to campus, military transfer credit, financial aid, Disability Services, career development, GI Bill benefits, and tips for success in college.
If you are unable to attend one of our orientations, you can complete the online Transfer and Nontraditional orientation via https://www.wright.edu/transfer/orientation. This orientation consists of multiple modules that you can complete in any order. You can return to it whenever you like.
Spring 2018 Orientation
Details TBD-check back for updated information.
RSVP to firstname.lastname@example.com


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Disability Accommodations
Swarthmore's Student Disability Service is pleased to work with students with disabilities to identify accommodations that will allow equal access to college programs and services. If you are a student with a documented disability and have not already done so, please complete the online Voluntary Disability Disclosure Form by June 1. Please send your supporting clinical documentation by the recommended date of June 15. Some accommodations can take many weeks to arrange, and we want to be sure that your needs are met in time for classes.
To learn about the Student Disability Service and the accommodations process, please visit our Student Disability Service website.
Questions? Contact Leslie Hempling, Director of Student Disability Service at email@example.com or 610-690-5014. Fax: 610-328-8487


text: After the Newtown tragedy, Dicks Sporting Goods—which presumably entered the modern sporting rifle (MSR) market purely for financial gain when it saw other sporting good stores selling them by the truckload—screwed over hundreds or thousands of customers. It cancelled the rifles they'd ordered, as if they were criminals. DSG's respect for their customers was and […]Read the rest of this entry »


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They frolic in empty boxes and stick their heads under faucet streams of water. They dance on tippy toes and fly through the air with Pop-Tarts. They play piano wearing little frocks and get tickled to distraction to the delight of millions on YouTube.
I speak, of course, of the cat stars of the Internet, a place filled with felines and their wacky uploading humans since the dawn of bandwidth. Now, after years of viral viewing, they're coming into their own in lucrative and altruistic ways.
Corporate kittydom is happy with the higher profile for the cat meme, which actually goes back to the '70s, when swapping VHS tapes was big and the word meme was barely known. It means, by the way, all the crazy, viral themes that spread online faster than you can say nom, nom, nom (cat-vid speak for the sound of a cat eating.)
Roly poly Maru, the megastar in Japan with millions of views for nearly 300 videos since 2007, has three books and a calendar, among other swag for sale. The squishy-faced, often blissed-out Scottish fold who loves boxes and bags was used by Uniqlo when the Japanese brand launched its San Francisco store in October.
Not to be outdone, Simon's Cat, a funny feline in a series of line-drawn animated videos out of London, has a book and an online store, as does Henri, who lends his fame and some of his dollars to cat charities.
Even the funny-faced Grumpy Cat, whose real name is Tartar Sauce, coughs up some bucks to animal welfare groups, while captions for her still photos fly around the Internet and she sells T-shirts off her website.
So why cats?
Cats are fluffy and unpredictable and usually kept behind closed doors, which lends them allure and appeal when it comes to vapid, funny or deranged video. At least that's what cat fans think.
"Cats are going to do what they want to do, and that's one of the reasons that we love them," said David Kargas, a Fresh Steps spokesman who worked on Catdance, an evening of felines on screen that coincided with January's Sundance Film Festival in Park City, Utah.
These days in the cat-video game, acts of charity are expected as much as laughs, said William Braden, the Seattle filmmaker who morphed a pampered family cat named Henry into the French-speaking Henri for a 2006 film school project. Cranking out Henri videos and managing the black-and-white long hair's growing projects are now Braden's full-time job.
"On the one hand, you'd be stupid not to do charity because fans are sensitive," Braden said. "On the other hand, for the love of God, I make a living doing this. … How horrible would I be if I didn't give a little bit of it away?"


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Contact Us NowClick to fill out contact formFree Configuration AnalysisClick to fill out contact formWith MBX's 20-year tenure in the hardware business and 100% focus on purpose-built systems, we've developed a flexible framework to build performance-optimized platforms for your software and launch your hardware program in about 70 days.
Can it be done faster? Sure. But speed is no substitute for quality. Our unwavering commitment to maintaining over 99% quality rating is too important to sacrifice by rushing the process. Every one of our customers who made the switch from another OEM appliance builder to MBX would adamantly agree.
We build systems for some of the largest and most demanding application developers in the world. We're ready to take on your toughest challenges and show you why it's worth making the switch.


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I've gotten a couple of emails about the carnival that is set up outside of the Best Buy in Knightdale.
There's not a lot of information online about it. But Brian Bowman, the town's public information office, scouted out some information. It runs through Sunday. Hours are 5 p.m. to 10 p.m., nightly through Friday. It's noon to 11 p.m., Saturday, and 1 p.m. to 11 p.m., Sunday.
Mike, a Go Ask Mom reader who I met at the Harlem Globetrotters the other week, also went out there for more details. He said that all you can ride wristbands are $20 each and the food stands had $2 off coupons for the wrist bands when he was there.
The carnival is between Target and Best Buy at the shopping center just off Knightdale Boulevard near the interchange with I-540. I'm told you won't miss the Ferris wheel.
According to Knightdale's Facebook page, the carnival, in partnership with the Knightdale Police, donated about $14,000 to Special Olympics.


text: I have pretty much switched everyone over to bi weekly mowings now. We havent had any rain for quite a while and most are dirt brown already! And this year was going so good? It really sucks to be at the mercy of the weather all the time! How can you run a business without knowing what you will be bringing in from month to month? Hopefully we get a wet fall, but I doubt it. It was good while it lasted though! I guess thats why this season has gone so fast, its already sept.?????


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Spring Break Cruise: Carnival Triumph Cruise Review by SailingVol
Overall Member Rating
Spring Break Cruise
Destination: Eastern Caribbean
Embarkation: New Orleans
This is a smokey ship. I had read this in previous reviews and didn't know how to take that, but this is very true. There are designated smoking areas, but they are not policed by any means. The casino is dreadfully smokey at night so be aware!
The food quality was very well prepared. The menu was more tame than food on other ships I have been on, but the quality was top notch.
I enjoyed having a young entertainment staff. Jenn and Chicken were wonderful Cruise Director and Assistant. They were everywhere all day long and I really appreciated their energy! Entertainment fantastic! More Go to the late night comedy and burlesque show. Sometimes, it is nice to enjoy a dirty joke now and then without the sensor for family audiences.
If you are not from Louisiana, or New Orleans for that matter, you will feel like a minority. I think I can say I heard "Whoo Dat" more times in one week than I will the rest of my life :)
Another point to be weary of, is the buffet lines. This is something else I read about on many cruise reviews. Many cruisers were discussing this as well on board. Everyone seemed to have their own opinion as to why the lines are longer than other ships, but no one really knows. All I can say is, space out your eating times to avoid the inevitable lengthy line.
We found a quieter spot on the back of the ship to lay out. If you go back where the pizza station is and up one level, there is much less action since you are away from the hustle and bustle of the main pool. Big thumbs up here! You might have to grab your own chair, but it is oh so worth it!
THE GYM IS AMAZING! Very spacious with top of the line equipment. I worked out twice, and the equipment is nicer than that at my gym at home. It does get very hot, but that just burns more calories right? :)
Couple of things about the room. 1. We had an interior stateroom and there is a radio in the wall that plays on the speaker in the ceiling! We were smitten with this! 2. The closet space was impressive for the size of the room-we had three 26 year old women with enough space for all of our clothes 3. Our very small shower flooded once
Embarkation: Needs more attendant lines for check in. Once we were corraled to get on the boat, embarkation was passable. Just be prepared to hurry up and wait. Hotel recommendation: STAY AT THE DRURY INN!!!! Hands down, best for your money! They have a happy hour with drinks (alcoholic and non) and food. They also have a comp breakfast with hot food including a waffle station. They room was enormous and extremely comfortable. We paid $35 for parking for the week! Just be sure to tell them you are doing the Cruise and Park. Paid $7 each way for the taxi to and from the terminal. I cannot stress enough how relieved we were to not park at the terminal. This place is extremely clean, the staff is great, and it is blocks from the French Quarter.
Debarkation: This was a breeze! We did self assist and it was beyond easy. We each only had one bag plus "carry on" so we could carry it all ourselves. This put us in the first group to get off the ship, and saved us tons of time. Once we were off, we found a taxi and got back to the hotel in no more than five minutes!! We learned when parking at the terminal, they will only allow one person to go get the car while the rest of your party waits at the doors for you to find the car and drive around the block back to the terminal.
All in all a nice cruise! Less
Published 04/22/10
Cabin review: 1327
Quiet location Bathroom flooded once Tiny shower Dated decor Radio in the wall is very cool! Closet space was larger than expected
Port and Shore Excursions
Read Cruise Critic's Carnival Triumph Review >>
Incredible experience
This ship was too large to enj...
Fantastic 40th Anniversary Cru...
Decrepit ship, food failures, ...
Absolutely wonderful experienc...
Carnival Triumph review - seco...
Had a great time!!
Family Cruise
First cruise - The crowds both...
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Emerging Infections 1
- Edition:
- 1st
- Author(s):
- 9781555811211
- Format:
- Paperback
- Publication Date:
- November 06, 1997
- Content Details:
- 298 pages
- Language:
- English
Your Cart:
List Price: Sorry, not available in your region
Also of Interest
The Biology of Cancer, Second Edition
The Immune System, Fourth Edition
Molecular Biology of the Cell, Sixth Edition
About the Book
Book SummaryThis book is the first of an annual series of books which will be based on ICAAC Symposia on Emerging Infections. The editors are in the forefront of the scientific and clinical communities dealing with emerging pathogens. Each chapter is written by an expert in the field and will cover basic science as well as clinical topics. This book and the series will be valuable and popular for a wide range of people working in the fields of infectious diseases, internal medicine, and clinical microbiology.
ContentsTable of Contents Epidemic Dengue and Dengue Hemorrhagic Fever: a Global Public Health Problem in the 21st Century 1. Hemorrhagic Fevers: How They Wax and Wane 2. Recurrent Emergence of Venezuelan Equine Encephalomyelitis 3. Flying Foxes, Horses, and Humans: a Zoonosis Caused by a New Member of the Paramyxoviridae 4. The Reemergence of Rabies 5. Emerging Human Ehrlichioses: Recently Recognized, Widely Distributed, Life-Threatening Tick-Borne Diseases 6. The Reemergence of Severe Group A Streptococcal Disease: an Evolutionary Perspective 7. Patterns in the Emergence of Epidemic Meningococcal Disease 8. Escherichia coli O157:H7 9. Bartonella: an Emerging Human Pathogen 10. Epidemic Diptheria in the Newly Independent States of the Former Soviet Union 11. A Convergence of Tick-Transmitted Diseases within the Lyme Disease Transmission Cycle 12. Helicobacter pylori and Gastroduodenal Disorders 13. The Changing Nature of Nontuberculous Mycobacteriology 14. Emerging Fungal Pathogens: Evolving Challenges to Immunocompromised Patients 15. Emerging Enteric Protozoa: Cryptosporidium, Cyclospora, and Microsporidia 16. Emerging and Reemerging Infections: the Critical Societal Determinants, Their Mitigation, and Our Responsibilities 17. Addressing the Challenges of Emerging Infectious Diseases: Implementation of the strategy of the Centers for Disease Control and Prevention


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Cleveland Hopkins sees passenger traffic edge higher in 2013Comments Email Print
Passenger volume for the year was 9,072,126, up 0.68% from 2012's 9,010,473 passengers, an increase of 61,653 travelers.
"While the increase is modest, we still look at it as a great positive," said Ricky Smith, director of the city airport system, in a news release. "Over the last several years, largely due to the national recession, CLE has experienced passenger traffic reductions.
"This increase is an indicator that demand is slowly coming back," he said.
Contributing to the increase in passengers was a 32% increase in international travelers, the city reported. Passengers can connect directly to Montreal; Toronto; Cancun, Mexico; Punta Cana, Dominican Republic; and Nassau, Bahamas, from Cleveland.
It also helped that passenger volume in December jumped 6.25% from the like month of 2012.


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CROCS 'Cayman' Sandal
Can't argue with comfort. Thanks Santa. I didn't realize you are so fashionable.
This has got to be one of the best shoe storage inventions of the century - the Shoe Wheel by Rakku. Sleek and gorgeous. Get to stare at my fab collection of clip clops. I found it at tszuji
This is the best bento box ever!Added 9 Years Ago from Amazon.com
Easy interface, great for storing unlimited amounts of photos... I have way too many photos on my Flickr account... 25,000+ to be exact!Tags: cameras, storage, digital, video, photography, community, family, photos, digital photographyAdded 9 Years Ago from Flickr


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air max 2016 shoe
Designed to offer maximum flexibility and cushioning, the full length Nike Air Max 2016 Shoe is designed with an engineered mesh upper for ventilation. The midsole is grooved for greater foot flexibility. A clear rubber outsole offers fabulous multi-surface traction and a smooth foot strike.
- Full-length Max Air unit delivers flexible cushioning
- Engineered mesh upper ventilates your forefoot
- Integrated Flywire cables ;leave your foot with an adaptive support
- Hexagonal flex grooves bring greater forefoot flexibility
- Rubber Waffle outsole provides great multi-surface traction
You can return your items for free within 14 days of purchase. Returns numbers must be requested within 7 days of receiving your order and you will have a further 7 days to return unsuitable items. For more information please refer to our Returns Policy page. We deliver straight to your doorstep across the UAE and GCC; if you require further information please refer to our Shipping Policy page.
If you need any assistance please use our chat.


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First Look: Ben Whishaw as the Young, New Q in 'Skyfall' Revealed
by Alex Billington
July 12, 2012
Source: 007.com
One of my personal all-time favorite characters is Q, from the Bond series, originally played by Desmond Llewelyn in 17 of the original Bond films. Llewelyn sadly passed away in 1999, and while they've toyed with the character, ever since the Daniel Craig Bonds have started, they've kept Q entirely out of the equation. But then they announced Ben Whishaw would be playing Q in Sam Mendes' Skyfall. How would he look? Would he be extremely young, or just a smart scientist? Would he better than John Cleese (ugh)? Well, now we know, the first official photo of Whishaw as Q has been revealed, and he looks good. But also very young.
Here's the shot of Ben Whishaw as Q, debuted on 007.com. It's not too much, but I like his glasses at least.
Skyfall is being directed by Sam Mendes (American Beauty, Road to Perdition, Jarhead, Revolutionary Road, Away We Go), from a script by John Logan, Neal Purvis and Robert Wade. Skyfall will once again star Daniel Craig as James Bond 007, along with Javier Bardem, Dame Judi Dench as M, Ralph Fiennes, Albert Finney, Naomie Harris, Bérénice Marlohe, Helen McCrory, Ola Rapace with Ben Whishaw. You can also follow the official twitter @007 for updates as well, they've been tweeting photos and more. Columbia Pictures, Eon Productions and MGM have Skyfall set to hit US theaters on November 9th this fall. We'll continue to keep you updated on all things Bond. Read my on set experience from Istanbul and stay tuned.
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