text:
FROME Town slipped to a second successive defeat as they were brushed aside at play-off chasing St Albans City last weekend.
In one of only three clashes to survive the wet weather in the Calor League Premier Division, Robins chief Adrian Foster was forced to re-shuffle his defence, with new signing Jack Vallis partnering Josh Ford in the centre of defence and Brandon Mundy moving in to the back line in the absence of suspended duo Mark Cooper and Tim Stephenson.
Frome carved out a chance to take the lead in the the ninth minute, with great build-up play seeing Matt Groves tee up Ben Wood, who then rolled the ball into Aaron Ledgister, but his first-time strike was tipped over the bar by Paul Bastock.
St Albans replied in the 15th minute as John Frendo rolled the ball back to Jamal Lowe from the far post but his strike was held comfortably by Darren Chitty.
The hosts started to get into their stride and in the 23rd minute, Frendo rose above everyone and headed the ball back across the goal but Rhys Baggridge reacted quickly to head over his own bar.
Wood brought another save from keeper Bastock in the 27th minute but two minutes later, Foster's men were behind as an outstanding low cross from Howard Hall was converted by Lowe, who prodded the ball home past Chitty.
The hosts should have doubled their lead a minute later as the ball went through under Ledgister's foot, allowing David Keenleyside a run on goal, but he shot wide with only Chitty to beat.
The pressure continued but Ledgister denied the hosts with two blocks and then keeper Chitty saved well with feet to deny James Comley.
Then, Keenleyside's cross was cleared by Baggridge but the ball was headed back in and Frendo almost slid home at the far post.
Two goals in three minutes just after half-time finally killed off Frome's chances, with the first arriving the the 50th minute as Lowe produced a peach of a pass to Keenleyside, allowing him to beat two defenders and loop the ball over Chitty with the aid of a deflection.
The third then arrived shortly afterwards as a through ball from Frendo set up Comley to shoot home with ease from close range.
Robins keeper Chitty saved superbly in the 62nd minute to deny Lowe and Frome's day was well and truly done and dusted five minutes later as Frendo rounded off a fine performance with a goal as he waltzed through the defence to net his 24th of the season at the near post.
The Robins' only real chance to grab a goal back came in the 75th minute as a great cross from Wood allowed Ricky Hulbert to thunder a shot against the home cross bar.
Foster's side go looking to bounce back when the y host bottom-of-the-table Bashley this weekend.
MORE FOOTBALL NEWS AND REACTION IN THIS FRIDAY'S WILTSHIRE TIMES. FOLLOW US ON TWITTER @WTSport


text:
Thinking about retiring? Timing is key.Comments Email Print
Because most people who retired in the late 1990's benefited from the stock market gains in the early years of their retirement, yet those retiring in the late 2000's started off with market losses. So what, you say? Well, that difference in investment returns – gains in early years vs. losses in early years – can dramatically impact your long-term ability to spend the same amount from your portfolio every year.
So what can you do, since you certainly can't predict what the market will do in the early years of your retirement? One potential key to success may be to divide your retirement spending into time periods – say five-year increments – then match part of your investments to that time-frame and each successive time-frame into the future. In the earlier time periods consider using more conservative strategies because you have little room for error; while in later time periods using more aggressive strategies may be appropriate because they will have time to recover. Thus, matching your investment assets to your exact spending needs may help avoid a major market wildcard.
Disclosures: Rates of return referenced above are hypothetical, are provided for illustrative purposes only, and do not reflect the performance of an actual investment. All investments involve the risk of potential investment losses and no strategy can assure a profit. Securities offered through Securities America, Inc., Member FINRA (www.finra.org )/SIPC (www.sipc.org ) and advisory services offered through Securities America Advisors, Inc. Cedar Brook Financial Partners, LLC and Securities America are unaffiliated. Securities licensed in: AZ, CA, DE, FL, IA, IL, NC, OH, PA, SC. 5885 Landerbrook Drive, Suite 200, Cleveland, OH 44124.

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National Science Foundation Participates in White House Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative
NSF-supported research in this area spans biology, mathematics, physical sciences, engineering, computer science, and social and behavioral sciences
President Obama today announced that the National Science Foundation (NSF) will participate in a White House initiative called Brain Research through Advancing Innovative Neurotechnologies (BRAIN), which is designed to revolutionize our understanding of the human brain. NSF Acting Director Cora Marrett took part in the announcement at the White House, which also included the National Institutes of Health and the Defense Advanced Research Projects Agency, as well as private sector representatives.
"NSF is ideally positioned to support the BRAIN Initiative because of the broad scope of science and engineering research funding we provide to the nation," Marrett said. "NSF's neuroscience and cognitive science research portfolio is expansive, and this initiative enhances efforts that are already underway to explore neurological connections from the cellular to human behavioral levels."
NSF intends to support approximately $20 million in research that will advance this $100 million initiative. The Foundation's contributions will include research into the development of molecular-scale probes that can sense and record the activity of neural networks; advances in "Big Data" that are necessary to analyze the huge amounts of information that will be generated; and increased understanding of how thoughts, emotions, actions and memories are represented in the brain.
Some of NSF's current investments in neuroscience research include:
For more information, go to www.NSF.gov/brain.
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The National Science Foundation (NSF) is an independent federal agency that supports fundamental research and education across all fields of science and engineering. In fiscal year (FY) 2017, its budget is $7.5 billion. NSF funds reach all 50 states through grants to nearly 2,000 colleges, universities and other institutions. Each year, NSF receives more than 48,000 competitive proposals for funding and makes about 12,000 new funding awards.
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text: Almost certainly the best known American during his lifetime, William Cody was a skilled frontiersman in the first half of his life and a celebrity in the second. He got his nickname, "Buffalo Bill," in the 1860s while hunting buffalo for the railroad, killing more than 4,000. After working as an Army scout and in other "frontier" positions, Cody starred in a stage production for a decade before creating his successful "Buffalo Bill's Wild West" show. The show, which dramatized the American West and its cowboys and Indians, toured for 30 years, 10 of those in Europe. Cody continued the Wild West show up until the end of his life, and by his death over 70 million people had seen it.


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Aug. 25, 2009
Texas Hunters Should Ask To Get HIP
AUSTIN, Texas — Texas hunters need to make sure they are Harvest Information Program (HIP) certified before going hunting for dove, waterfowl or other migratory game birds this fall to avoid an unintentional game violation and possible citation. Specifically, hunters need to ask about HIP certification at the license sales counter, because some license clerks may not bring it up.
For several years, the U. S. Fish and Wildlife Service has been working with Texas Parks and Wildlife Department to help improve the quality of Texas HIP certification data that is used to qualify hunters for migratory bird harvest surveys, which some hunters may receive in the mail during the course of the coming hunting season. These surveys of dove and waterfowl hunters help the service and states determine the national harvest, and this information is used to set hunting season and bag limit regulations.
TPWD made a change in the electronic hunting and fishing license sales system this year, and this now means hunters should ask vendors for the HIP certification. Just as in recent years, hunters will answer a series of brief, simple questions about their recent game bird hunting activities to become HIP certified. There is no cost to license buyers for the certification.
"We have heard reports from some hunters that some license vendors are failing to ask if they want to be 'HIP,'" said Vernon Bevill, TPWD small game program director. "It is the hunter's responsibility to tell the clerk issuing their license that they want to answer the HIP questions and be certified."
Bevill went on to say, "The best time to get certified is when you buy the licenses and stamps you need. Tell the license clerk to be sure to ask you the HIP questions right then, and if you forget and remember later you should return to the same store, if convenient, and get certified. The HIP permit is free."
TPWD and the Service are working to improve the accuracy of all migratory game bird harvest surveys. Some hunters think the answers they give in the store is the survey, but HIP certification only places hunters into categories of high, medium or low harvest of dove, ducks or other migratory game birds. The information is collected at the state level and then sent to the Service so they can more accurately survey hunters in states like Texas. Each harvest category is surveyed at slightly different rates to gain the full estimate of dove, duck, and goose harvest.
"In prior years some license vendors would provide incorrect answers and certify hunters without them ever knowing they were certified," said Corey Mason, TPWD dove program leader. "This led to numerous problems with the Texas data, and we need to obtain better information because Texans harvest more dove and waterfowl than any other state in the Central Flyway. "
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text:
AMD Set To Announce New FX Processorsby Brett Howse on 8/26/2014 8:00 AM EST
40 Comments
Back to Article
JDG1980 - Tuesday, August 26, 2014 - linkI don't like at all that they're failing to specify base clock speeds. Will this become a trend like it has with their newer graphics cards? For CPUs, that's absolutely unacceptable.
I want AMD to succeed, but their marketers really make it hard to like them. Reply
nathanddrews - Tuesday, August 26, 2014 - linkAt least it's not as bad* as the Athlon XP+ days, when they named the processors after the relative performance compared to their older CPUs. "Wait, so the Athlon 3200+ is actually running at 2200MHz?"
*Referring only the the PR campaigns of AMD and Intel, not the actual CPUs themselves. Reply
Beany2013 - Tuesday, August 26, 2014 - linkActually, it was meant to help consumers understand that a 2200mhz Athlon was trading blows (well, certainly not far off) from the 3.2ghz P4s of the day:
Show a consumer a P4 2.4ghz, for example and an Athlon 2.2ghz and they'll go for the 'bigger' number every time, even though the Athlon 2.2ghz would walk all over the 2.4ghz Intel chip - so there was at least a fully justified reason for it.
So they had to compare it to something, or they'd be tanked on the showroom floor. Performance rating helped with that.
I'd like to know the low end power usage, idle figures, frankly. I have a CPU monitor on my taskbar (linux, natch) and the CPU doesn't spin up very often - so total TDP isn't that relevant....
But yeah, not ideal by any stretch, and aside from that, AMD need to GTF away from the Piledriver microarch - it's seriously creaking these days, it's sad to say. Reply
nathanddrews - Tuesday, August 26, 2014 - linkContrary to myth, the performance ratings of the AMD CPUs were not created for comparison to Intel CPUs. There were many people that assumed that to be the case, but the product training that AMD supplied to retail employees (CompUSA, Best Buy, etc.) specifically called out comparisons to AMD's own CPUs when addressing the PR, not Intel's. If I had kept that old literature from my retail days, I would scan it for you to see, but you'll just have to take my word for it. :| Reply
Flunk - Tuesday, August 26, 2014 - linkYes, that was what AMD claimed to avoid being sued. Reply
bigboxes - Tuesday, August 26, 2014 - linkWhat Flunk said. You were told that lie to keep AMD from being sued. Everyone knew it was a comparison between the performance of the AMD processors and the rated speed of the Intel chips.
I sure miss being able to build an affordable high end rig. Yes, my main rig is an i7 and is a monster. That's pretty much what us enthusiasts have had to do. I just retired my first dual-core (Athlon 64 X2 4400) due to a failing mobo. Makes me sad. Reply
Samus - Tuesday, August 26, 2014 - linkYep, but now Intel needs a processor rating system since AMD is the one pushing ridiculous clock speeds with diminishing returns. 220w for 5GHz?
An 88w Intel 4790K @ 4GHz stock is faster. And although it costs more, there is more performance headroom in overclocking (4.6GHz+ isn't uncommon) and the fact is runs on nearly 1/3rd the power at full load indicates a lower electric bill and lower cooling costs.
I also question the longterm reliability of motherboard VRM's when pumping out 220w of juice... Reply
just4U - Wednesday, August 27, 2014 - linkWhy would Intel need a rating? They have proven that it doesn't matter if they have the better CPU in regards to and. Their still going to sell boatloads more. Since they took back the performance lead we get slot of side ways jumps but nothing like the jump that was seen with the core & athlon before it. Reply
just4U - Wednesday, August 27, 2014 - linkBah tablet typing.. sorry. Reply
piroroadkill - Tuesday, August 26, 2014 - linkSo it's still crap, but at least it won't be as hot. This wasn't as exciting as it should have been. Reply
barleyguy - Tuesday, August 26, 2014 - linkMight be a nice upgrade from my FX-6300. I mainly use that machine for video encoding (Handbrake or Makemkv), so will be keeping an eye here for benchmarks.
The 6-packs remind me of AMD in the late 90's. They used to have 5 packs, and they also came with a sheet of stickers for the front of machines. That was a popular option back when small computer stores were thriving... Buy 5 AMD processors, build 5 machines, post a sale sign, and profit. ;-)
I'm not sure how much of that goes on nowadays. The small clone builder culture seems to have mostly dried up... Reply
ayqazi - Tuesday, August 26, 2014 - linkWish they'd repackage these into FM2+ like those other FX CPUs they released, then we can use them on more modern motherboards with more form factor variety (I'm looking at you, mini-itx). Reply
ayqazi - Tuesday, August 26, 2014 - linkWhoops, I realised my mistake: I thought they had released FX parts on FM2+, they obviously haven't. Reply
Flunk - Tuesday, August 26, 2014 - linkI'd prefer they release A-series processors that totally blow the FX chips out of the water, then AMD can focus on one line of desktop processors instead of two. Reply
Jumangi - Tuesday, August 26, 2014 - linkThey basically are. These are nothing more than slight updates to CPU's that came out almost 2 years ago. They have somewhat lower power usage which means pretty much nothing in the desktop world. It's AMD trying to milk a little more life out of a processor line that is basically dead now. The future is all about the A series for them. Reply
Kjella - Tuesday, August 26, 2014 - linkThese very minor bumps come from power and frequency binning as well as slightly refined manufacturing tolerances. No new R&D went into making these chips, there's no architecture refinements and no process improvements. As for their remaining line of processors, they're basically laptop chips on steroids. Okay if you need on-board graphics but quoting the Anandtech review: "a dual-core Core i3 Haswell will deliver much better CPU performance than even the fastest Kaveri at a lower price." so if you care enough about graphics to get a discrete card you won't buy it. If you don't care about graphics at all, you won't buy it. I guess it's the cheap all-in-ones but it's the jack of all trades, master of none. Reply
just4U - Wednesday, August 27, 2014 - linkI'd take. A A8-7600 over any i3 on the market today.. the CPU may be slower but for most that's not going to be noticed.... Reply
flyingpants1 - Wednesday, August 27, 2014 - linkI'm sorry, what? Reply
Masospaghetti - Tuesday, August 26, 2014 - linkAMD's marketing is awful. I've rooted for them forever, but they must have a bunch of 10 year olds coming up with new names and brands. Reply
Flunk - Tuesday, August 26, 2014 - linkNew chips that slot into the middle of their product line aren't particularly exciting. 8350 + 100Mhz of turbo = 8370 I guess. Reply
Alexvrb - Tuesday, August 26, 2014 - linkWell I've read some sources that the base clock is also 100Mhz higher. Not that this changes much, and overall I would tend to agree with what you've said. On the other hand if it's a better bin it might be a better overclocker. At a minimum new releases might help to push prices down on the lower models.
Out of curiousity, does anyone know if it's still C0 stepping? Reply
mgilbert - Tuesday, August 26, 2014 - linkI want AMD to succeed as much as anyone, as competition benefits the technology and the end user, but a TDP of 225 watts for a CPU that can't outperform an Intel processor that generates less than half that much heat? AMD has a long way to go... Reply
hojnikb - Tuesday, August 26, 2014 - linkThey should rather focus on the chipset front, insteand of releasing new bins of old arch.
9 series is getting really old now. Reply
SlowSpyder - Tuesday, August 26, 2014 - linkAwesome seeing AM3+ still getting some love from AMD! Reply
Malih - Tuesday, August 26, 2014 - linkDon't really care much about AM socket CPUs anymore, I'm very interested in FM socket CPUs though, I like building a mini ITX systems as a hobby at least once a year. Reply
willis936 - Tuesday, August 26, 2014 - link>new FX SKUs
:( Reply
iwod - Tuesday, August 26, 2014 - linkCome On! All of these FX processors uses Double the Power while being like 50% Slower.
That is a 4x difference in pref / watts!
Has AMD given up completing in x86 market? Reply
LarsBars - Tuesday, August 26, 2014 - linkIf these new SKUs were steamroller or excavator, I think there would be a lot more excitement around them... Reply
LarsBars - Tuesday, August 26, 2014 - linkHa! I like how Brett's AMD FX CPU comparison doesn't even have a core count, that's great! :) Reply
barleyguy - Tuesday, August 26, 2014 - linkThe table in the article has the number of modules for each chip. The integer cores are 2x the number of modules, so all of these processors are 8 cores. Reply
silverblue - Tuesday, August 26, 2014 - linkI find some amusement in the complaints regarding AMD's product naming schemes. It's not as intuitive as it should be, but it could be worse. The general rule - as should be understood by now - is that the first number is the core count, the second is the generation (in odd numbers), the third is its position within the hierarchy (i.e. bigger is better) and the fourth is always a zero. It's only really the 9xxx series which has fouled things up totally. The real shame is that we don't get a 200MHz stepping per every 10 in the model number like we did with Phenom II. Reply
silverblue - Tuesday, August 26, 2014 - link(with a general understanding that the bottom of the rung models would be 2.4GHz as they had two trailing zeroes) Reply
eachus - Tuesday, August 26, 2014 - link"Base frequency" is mostly meaningless with modern CPUs. If the CPU is lightly loaded, you might find it running at 600 MHz or so. Fully load at least one core, and that core will jump to the "turbo" speed. What if you run all cores flat out? Depends on the instruction mix whether the processor will hit the power cap and slow down. How much will it slow down? Depends on the code you are running. I have an AMD 6-core CPU and I dedicate 4 cores to Prime95 if I am not doing other number crunching. Such as trying to get a few percent more performance out of code which fully loads the floating point cores. (How do I get more crunching? Tweaking the code to decrease L2 collisions.)
Now running my fp-code for linear programming, you will top out the fp-units and put a pretty heavy load on the integer CPU portion as well, doing indexing. On an AMD CPU you might as well run the code on half the cores (and make sure to use only even or only odd) cores since that will max out both the fp units and memory access. So what is the right number for max performance? Here you have say three cores running flat out, three cores mostly in halt states, and performance is effectively gated by main memory access. (Yes, I have code that runs much faster when running with all data to and from L2. But for large arrays, you have to use main memory if only to read the data (once) and write the results. And as I said, I keep trying to reduce L2 collisions..)
Oh, and I hope AMD certs these CPUs for DDR3-2166, even though I run my memory there anyway. ;-) Or they could finally start shipping DDR4 SKUs. AFAIK, their CPUs have been DDR4 ready for at least six months, but they need someone to provide mobos. Reply
chiechien - Tuesday, August 26, 2014 - linkNew Piledriver cores? Not helping. Reply
TheinsanegamerN - Tuesday, August 26, 2014 - linkhey, AMD, you know what would be much more impressive and sell way more than yet ANOTHER binned piledriver chip from 2012? AN EIGHT CORE STEAMROLLER CPU!. or a six core. built on 28nm, of course. You are not intel, you cant say "this is what consumers want" and expect people to buy it. Stop making us wait already and give us a new fx steamroller chip. Reply
silverblue - Tuesday, August 26, 2014 - linkIt wouldn't work. The process is tuned more towards power savings and as such won't clock as high. If you were to overclock to at least 8350 levels, it'd probably start to use way too much power... precisely the reason why the architecture is flawed.
In any case, there's not a large difference in single threaded performance, and floating point performance has, rather strangely, regressed slightly, so an FX-class chip would only make sense for multithreading, not gaming. Reply
roadapathy - Wednesday, August 27, 2014 - linkOh, so it's -still- 32nm wafer. Yeah. Talk about putting lipstick on a pig. Does the PR department run AMD or do they sometimes listen to the techies? Reply
Leonard Emery - Wednesday, August 27, 2014 - linkBeing a big AMD fan this is kind of discouraging. No new enthusiast dekstop CPU's for years now. Just crappy refreshes and reworks of the power hungry Piledriver architecture. My next system will be X99. Farewell AMD. My wallet will never be the same.... Reply
flyingpants1 - Wednesday, August 27, 2014 - linkBut you knew this would happen. This is how capitalism works. What exactly do you expect them to do? Reply
East17 - Wednesday, September 03, 2014 - linkAMD will hardly stand a chance, if developers continue to use Intel's compiler and don't patch their products to stop identifying the CPU on the system and running the "most compatible" (read -much slower-) routine every time they find an AMD chip.
Out of respect for their customers, software developers should offer a correctly and completely optimized product.
Intel's compiler of one of the best ones on the market and it's free. But if Intel is free not to play fair, the software developer should do his duty to his customer and offer a correctly optimized product.
I believe that AnandTech should check to see if the benchmarks used treat the processors objectively and point out to the readers the tests that involve software that runs the "most compatible" routine, each time it finds and AMD chip. Reply


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Is HCV the new HIV? Health Activists Meet to Develop Strategies to Improve Access to HCV Treatment
Sean Flynn
March 31, 2009
Another lifesaving treatment is being denied to the world's poor through global pricing that provides access only to the nation's wealthy. A biologic drug called pegylated interferon can cure Hepatitis C (HCV) in over half of the patients that take it. But at a global price of over $20,000 a year, only a small portion of the world's 150 million people living with HCV can afford access.
The situation is reminiscent of the late 1990s when breakthrough triple drug HIV therapies were priced throughout the world at over $12,000 a year, excluding the majority of the affected population from access. Will the same strategies that pressed the lowest global price for an effective AIDS treatment to under $100 a year today be effective at improving access to affordable HCV treatment? That question lied at the heart of a meeting in Kiev last week of public health advocates, academics, lawyers, drug manufacturers and representatives of the Open Society Institute.
This note provides some background information on the problems being faced in promoting access to HCV treatment. The information is derived from presentations at the meeting and in the background documents, particularly from the draft background report circulated to meeting participants by Jeff Hoover, titled: "Shining a Light on a Hidden Epidemic: Why and How Civil Society Advocates Can Support the Expansion of Hepatitis C Treatment in Eastern Europe and Central Asia."
Following the background information, I provide some preliminary thoughts on next steps for public health advocates researching strategies to address IP barriers to HCV treatment access.
HCV Prevalence
Hepatitis is an inflammation of the liver that reduces the liver's ability to filter bodily waste and regulate a wide range of essential biological functions. Hepatitis C (HCV) was identified as a distinct strain in the 1980s. There are three main genotypes of HCV, of which genotype 1 is the most common. It accounts for 60 percent of HCV infections, including the majority in Eastern Europe and Central Asia (EECA). It is also the hardest to treat.
Symptoms from chronic HCV disease vary widely by patient and often include fatigue, depression, aches and pains, and forgetfulness. The lack of clear symptoms makes HCV difficult to diagnose. There are several tests for HCV, the best of which is a PCR viral load test that is relatively expensive and lacks robust generic competition in most countries.
In Russia, Georgia and Ukraine, official statistics suggest that 2-5 percent of the general population is affected with HCV. About half of people living with HIV are co-infected and up to 90 percent of IDUs are infected. Similar levels of prevalence are reported in India and Thailand.
Globally, there are about 150 million people living with HCV. There are 3-4 million new infections a year. HCV is the world's number one cause of liver disease.
The highest prevalence of HCV in the world is in Egypt, where it is estimated that up to a fifth of the population is infected. Widespread transmission in Egypt has been traced to a botched immunization program that for decades used improperly sterilized needles to infect millions of people. Importantly, there is now a generic version of peg-interferon in use in Egypt, as discussed below.
The best available treatment for HCV is a combination therapy including a widely available generic drug, ribavirin, and a widely patented biologic treatment called pegylated interferon (peg interferon). Use of the combination therapy including pegylated interferon was approved by the U.S. FDA in 2001 and has been international best practice for over a decade.
Interferon is a naturally occurring protein that helps boost the immune system and combat the HCV virus. Treatment of patients with non-pegylated interferon combined with ribavirin is effective at suppressing, but not curing, HCV.
Pegylation, which refers to the linking of a peg molecule (which is similar to a long sugar molecule) to interferon provides two major benefits. First, it allows more time between injections of interferon, thus reducing side effects and increasing adherence. More importantly, in about 50-60 percent of patients, peg interferon completely cures the virus, which non-peg interferon combination therapy cannot achieve.
Side effects from peg interferon combination therapy are relatively severe. Side effects include fairly common flu-like symptoms following the weekly injections. More severe depression, anxiety and anemia occur in about a quarter of patients.
The efficacy of the treatment varies depending on the genotype of HCV that a person has. The treatment is about 50 percent effective for Genotype 1 HCV, which is the most common type in many countries. Treatment is more effective in genotype 2 or 3 patients.
Access barriers
The brand name product, which is the only product available in many countries of the region, is provided from two multinational companies -- Roche and Schering-Plough. It is thought that each company has a separate patent on different versions of the drug that share similar properties.
Hoover explains:
"Generic versions of ribavirin are available, but for years pegylated interferon has been available only in two brand-name versions: Pegasys, made by Roche, and Schering-Plough's PegIntron. The lack of generic alternatives means that a standard 48-week course of treatment for HCV infection can cost more than $20,000 even in resource-constrained countries such as those in Eastern Europe and Central Asia. As a result, most health systems either cannot or refuse to pay for the highest-quality HCV treatment for the majority of patients in need."
There are no global price discrimination policies by the multinational companies to lower prices for poorer countries or public programs, as is now widespread for AIDS medications. It appears that every country in the world is being required to pay essentially the same price for access to the drug. This pricing strategy is not surprising – monopoly economic models suggest that the most profitable pricing behavior for a provider of an essential product will be to price to the global top income earners, which may justify a set price for the globe regardless of median income levels (see Flynn, Hollis, Palmedo 2009).
Russia may soon lack any access to peg interferon because of a recent law banning the importation of medicines into the country. According to two people at the meeting, about 6 months ago Russia passed a law banning the marketing of any medicine in Russia that was not locally manufactured. There is no peg interferon manufactured in Russia.
A representative of a Russian pharmaceutical company described the new requirements and explained the main treatment response in Russia is to promote non-peg interferon treatments. As discussed above, non-peg interferon is a dramatically inferior treatment because it cannot cure the disease, as peg interferon can in 50 percent of patients.
Patents and competition
Pegylated interferon is widely patented in the region, including in Russia and Ukraine – the two countries in the region with the largest populations. The patents cover a combination of two non-patentable inventions. Neither peg nor interferon is patentable when used alone.
Two presenters at the meeting referred to an understanding that Chiron holds a patent on the DNA or gene sequencing of HCV that restricts other companies from creating competing diagnostic tests. It seems unlikely, however, that there exist such patents widely outside of the U.S.
Generic peg interferon
In the absence of patent barriers to entry, there would likely be a robust generic market for non-pegylated interferon.
The potential suppliers of peg interferon are quite numerous. A medical researcher at the meeting reported that once a firm has the capacity to make interferon itself, attaching the peg is a relatively simple step that any supplier of non-peg interferon could master. It is estimated that there are at least 20 companies around the world making high quality non-peg interferon presently.
There is a generic version of peg interferon currently available from Egyptian manufacturer Minapharm. The drug, known as "Relferon," has been in use in Egypt since 2006 and is currently sold at about 25 percent of the branded price (approximately $4,000 /year). The patent and licensing status of Relferon is unclear. There have been suggestions that the product may be produced under a patent or know how license from Schering Plough. Hoover's paper reports being told in an interview that a German firm extended a license (presumably a know how license) to it. Minapharm has not responded to inquiries and this information is largely conjecture.
There are reportedly several Chinese companies that currently make peg interferon. There have been unconfirmed rumors of quality problems with these products.
Peg Interferon is patented in India. It is unkown the extent to which it is patented in other possible producing countries such as Thailand, India and South Africa.
Indian pharmaceutical firm Wockhardt challenged a patent granted to Roche in India for Pegasys. That challenge, filed in 2007, was later joined by Indian NGO Sankalp, which works with intravenous drug users and was represented by the Lawyer's Collective. The briefing in the post-grant challenges has been completed and the parties are now awaiting a decision. A key argument in the cases is that peg interferon is a combination of two known substances – peg and interferon – neither of which is itself patentable.
There are other Indian biotech firms, including Shantha Biotech and Bharath Biotech, thought to be interested in peg interferon production should the patent barrier in India be eased.
Downstream innovations
There are companies developing new methods of altering interferon to achieve pegylation in ways that do not violate the Schering and Roche patents and therefore may not need compulsory licenses to supply the world market.
In the U.S., Human Genome Sciences and Novartis are developing "Albuferon." The treatment will presumably be patented and targeted at wealthy countries.
Poly Therics invented (and has patented in four countries) a new pegylated interferon placing a peg in a different part of the interferon molecule. The inventors have licensed Shantha Biotech in India to take the medicine through the final clinical trials and produce and market the product. The drug will go into clinical trials in India in end of 2009. French biotech firm Biomerieux has bought Shantha and is continuing development of the drug. The goal of the firm is to focus initial product marketing in the developing world for approximately $2,000 per course of treatment.
Competition problems in supply of peg raw material
There may be immediate supply problems with obtaining pharmaceutical quality peg to link to interferon. High quality peg is relatively difficult to produce, contrasted with the process of linking the peg to interferon which is reportedly relatively simple.
There is one main supply of peg currently – Nektar in Japan – which supplies Roche and Schering Plough. Nektar has reportedly been very unresponsive to requests to purchase small amounts of peg for developing competing products.
There is one known alternative supplier of peg. Biovectra of Canada was established at a university with government support and now provides peg to Shantha.
Pipeline for new HCV treatments
There are other drugs in R&D pipelines that are attempting to improve the efficacy of the peg interferon treatment by adding a third drug to the treatment cocktail. Any of these drugs appear to be at least two years away from marketing.
Thoughts on the way forward
It appears from the information shared at the meeting that a compulsory licensing or other strategy to bring down patent barriers to the marketing of generic forms of pegylated interferon could be effective at improving access to affordable treatment for HCV. The current global price for pegylated interferon is incredibly high – reminiscent of AIDS drugs in the 1990s before campaigns to shame companies and support generic production began. If there were no patent or registration barriers to marketing generic peg interferon, it seems likely that a large number of generic producers (e.g. those currently making non-peg interferon) would compete in supply markets and force prices down to much more affordable levels. Immediate savings of 75-80% appear likely. Longer term, prices may be pushed much lower.
Patent pools may help promote further downstream innovation, particularly for firms that are seeking to develop new versions of HCV combination therapy that add a third drug to the existing two-drug treatment.
There should be further investigation into the patent and licensing status of Relferon in Egypt. If the product is being produced under license from Schering Plough, could parallel importation be used to access the drug in other countries i.e. does the license exhaust Schering's rights in countries with international exhaustion rules?)? Is the drug one of high quality? Are their licensing or other conditions that would prevent export of the drug to other countries? If so, could those provisions be challenged under patent, completion or human rights law provisions?
India is likely to be a key site of advocacy. If the current challenge to peg interferon patents fail, research into other licensing strategies will become necessary. Given the likely need to establish export capacities in India, these strategies will likely need to include either use of competition grounds for licenses (thus allowing unlimited exports under TRIPS article 31(k)) or utilization of India's "paragraph 6" implementing language.
More research should be conducted on best practices for biologic product registration for implementation in developing countries. Biologic drugs are a new technology, and most countries lack a specifically defined avenue for registering generic versions of biologic treatments. The U.S. is currently developing legislation to open a registration pathway for generic drugs and the EU has had such a regulatory pathway for several years. The issue is unlikely to be addressed in developing country legislation, however. Research should be conducted on best practices for altering or interpreting registration procedures in developing countries to permit registration of quality generic biologic drugs.
On June 3, PIJIP and OSI will convene an expert meeting of IP specialists in Kiev to further discuss possible licensing and other solutions to the IP barriers to HCV treatment.
In September 2009, PIJIP and OSI plan to organize a training on intellectual property and access to medicines for health activists in the EECA.


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Looking for a chance to give your "less than loved" clothes a new lease on life? Cocktails & Clothes is the chance to donate new or gently used clothing to the Arizona Women's Education & Employment (AWEE) free Clothing Boutique for participants to have for job interviews or first week on the job.
Clothes can be dropped off at the annual event tomorrow, March 4, from 4:30 to 7:30 p.m. at the 19th Hole at the Adobe Golf Club at the Arizona Biltmore Resort, 2400 E. Missouri Ave. The event includes a raffle featuring custom-designed gift baskets each valued at $300 or more, a live auction, cocktails and hors d'oeuvres.
Tickets are $65 each and can be purchased at the door or by contacting Susan Lagasse at firstname.lastname@example.com or by calling (602) 223-4333).
Each year, Cocktails & Clothes provides hundreds of new and gently used professional dresses, suits, slacks, blouses, shoes, briefcases and purses, and slacks, shirts, ties, shoes and sports jackets for women, men and young adults entering or re-entering the workforce.
Sperry Van Ness is the Diamond Sponsor. Sapphire Sponsors are Alliance Bank of Arizona and Avnet. Topaz Sponsor is AmTrust Bank. Emerald Sponsors are DMB and Dunlap & Magee.
The event is organized by the Friends of AWEE. Committee members are Phyllis Dumond, Judi Butterworth, Jami Savage, Kathy Jorgenson, Heather Moos, Nicole Ridberg, Carol Vernon, Sharon Contorno, Judy Jones, Arica Bec, Alison Harris, Roseann Marchett, Joe Hogan, Wendy Carlos, Victoria Benavidez and Shannon Ellermann.
For more information, visit www.awee.org.


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DIDEM URER: Mrs. Emine Erdogan noted that the Prophet (saas) is the prophet of love, the prophet of compassion and affection and said, "It is impossible to find any negative moment or any negative scene, let alone for us and our children, but also for the children of societies from other faiths as well. We must not deprive both our children and all the children of the world of learning about such an exemplary life" during her speech at the Holy Birth Week.
ADNAN OKTAR: Very nice. We send our sincere regards to our mother Mrs. Erdogan. We send our respects. May Allah bless her. May Allah grant her a long life. May Allah remove all troubles and harm from her and our Prime Minister. If they have any troubles, may Allah remove them.
We need a brave initiative from the Ministry of Education in order to eradicate Darwinism and materialism. The Ministry of Education should show paleontological evidence, fossils, to the young people. Now there are 500 million fossils already found. There is no need to explain Darwinism or criticize materialism. We will only display the fossils on a table, and the show is over, because they have never changed. This is very clear. Everyone from seven to seventy can understand this.
To end this fallacy, if Mrs. Erdogan gives a speech about this, the ground would shake, as she is not a politician. Let us hear something like this from her . She could say that she is against Darwinism and materialism briefly as she already is. This would be extremely effective as she is the spouse of the Prime Minister. This would also represent the view of our Prime Minister. Maybe the Prime Minister could not say this out loud due to his political status, but our mother could say this easily. She could say, "Let's display paleontological evidences." Our mother could say, "Let's announce that Darwinism and materialism is a fallacy with all the facts against it provided by science." If she could consider and make a brief or detailed explanation of this, this would make history. Of course, this is entirely for the good pleasure of Allah. (Adnan Oktar, April 13th, 2013: A9 TV)
2013-04-23 12:26:53


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No-Contact Jacket
Okay, girlies, this ROCKS! The No-Contact Jacket is a wearable defensive jacket created to aid women in their struggle for protection from violence. When activated by the wearer, 80,000 volts of low amperage electric current pulses just below the surface shell of the entire jacket. This exo-electric armor prevents any person from unauthorized contact with the wearer's body. If an assailant were to grab hold of the wearer the high voltage exterior would interrupt their neurological impulses which control voluntary muscle movement. " The Jacket has a unique electrically insulated rubber layer between the wearer and the electrified outer layer, which will keep the electric current from coming in contact with them.


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Mission. Regulatory Affairs Community members discuss non-proprietary topics and techniques for regulatory activities related to development and commercialization in the biopharmaceutical environment of products intended to diagnose, treat, and cure illnesses, and to share best practices across the global product development industry.
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Topic: Y90 while doing Gem/Cis
Do most people do Y90 while on Gem/Cis or separately? My husband is 38 and completely healthy outside of the CC:). I guess I should say symptom free. He has liver tumors and it has spread to the lymph nodes. The docs who we LOVE are willing to do all at the same time. I am curious if anyone else has done that and how rough was it?


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BT5 ARM? Is the Raspberry Pi invited to the party too? (I mean, I'd expect so, but I only see smartphone threads in this section so I thought I'd ask.)
The RasPi could be a pretty handy tool if paired with BT -- a super-customizable BT card which you could place in seemingly benign containers/locations for gathering data.
Or, y'know, just get a bunch of them spread out over some area and get exceptional wireless coverage, command your own team of nodes, etc.
Oh, yeah, this has to be a thread. Let's discuss any creative uses we can come up with using Raspberry Pi boards/systems and BackTrack.


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Reviews, reviews, reviews...
FreakScore is a weighted average of all aggregated professional and user review scores.
Read more
This product has a FreakScore of 3.9
out of 10 based on 127 scores.
The phone style of this phone is a slider. It can do automatic
Read more
Best Price at Amazon


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All Tags
For extra fun, compete against your friends or play with your family. Reset a quiz and take it again to increase your "Batting" average. Stuck on a question? Quickly bring in a "reliever", by emailing a friend directly from the quiz.
Publisher: Quizner's
Tags: US History Quiz 201, iphone application,
From PDA/MOBILE Software Category:
Of All:


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What is the MS Imagine / DreamSpark / MSDN Academic Alliance?
Who is eligible to download software through the DreamSpark?
What products and services are included in the DreamSpark membership?
Membership does not include Office and FrontPage.
Where can I get this software?
Where can I get help with, or more information about, DreamSpark?
What is the MS Imagine / Dreamspark / MSDN Academic Alliance?
MS Imagine (formerly known as DreamSpark and MSDN Academic Alliance) is a Microsoft Program that provides access to Microsoft software for learning, teaching and research purposes. The Engineering Computing Infrastructure manages this subscription and for each eligible department in the College provides access to DreamSpark through its online webstore at http://engineering-ucsb.onthehub.com. This software may be installed on any number of College lab machines. The software must be used for instructional and research purposes, it may not be used to run the infrastructure of the member departments. In addition, the department's faculty and students may check-out or download the software to install on their personal computers.
The program has two primary goals: 1) to make it easier and less expensive for you to obtain Microsoft developer tools, platforms, and servers for instructional and research purposes and 2) to build a community of instructors who can share curriculum and other learning resources to support the use of these technologies.
Who is eligible to download software through MS Imagine?
Our license allows the following individuals to install MS Imagine software on their personal computers for use in coursework and personal non-commercial projects:
- Students taking at least one for-credit course offered by the member department
- Faculty members of the member department
- Staff directly responsible for administering the MS Imagine program
For information on whether your deparment is eligible, please see Microsoft's documentation by clicking here. If you are not in one of these groups you may purchase Microsoft products through the campus bookstore which has academic discounts.
What products and services are included in the MS Imagine membership?
- Visual Studio .NET Professional (including Student and Faculty Tools)
- Windows 7, 8 and 10, and other Microsoft operating systems
- .NET Enterprise Servers: Windows servers, SQL Server, Exchange Server, Commerce Server, BizTalk Server, Host Integration Server, Systems Management Server, Sharepoint Portal Server, and several others
- Microsoft Project Professional
- Microsoft Visio Professional
- Microsoft Robotics Developer's Studio
- Software development kits (SDKs), betas, new releases, and updates
- Development tools for Windows CE
Membership does not include Office and FrontPage.
No, the membership does not include Office or FrontPage. The focus of DreamSpark is on providing departments, faculty, and students with the tools necessary for specialized research and study in software development and testing. Thus, Microsoft provides products and technologies such as Windows 8, Visual Studio .NET, SQL Server, and Platform SDK.
Office and FrontPage are not in line with these specific goals, since the program is primarily focused on high-end technologies rather than basic web design and consumer applications. Note: the DreamSpark Library does include developer documentation for Office.
The College has entered into the UC MCCA agreement with Microsoft. Our agreement covers Office (all versions, including Mac) for the faculty, lecturers, and staff. Unfortunately, they could not cover the students or researchers as this proved cost-prohibitive. People not covered by the MCCA agreement may obtain Office and other products at academic discounts through the Campus Bookstore.
Where can I get this software?
All software is available through the DreamSpark website. The URL is: http://engineering-ucsb.onthehub.com.The DreamSpark site offers two options for obtaining software:
1) direct download
2) postal delivery (fees may apply)
Where can I get help with, or more information about, MS Imagine?
Please read the MS Imagine FAQ before contacting either MS Imagine support or ECI. Additional information about the DreamSpark program can be found at their website: https://imagine.microsoft.com/en-us.


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This article, Hōzuki Castle, is canon and uses Creative Commons licensed content from our mother site, Narutopedia's Hōzuki Castle article.
The list of authors can be seen in the page history there.
This article, Hōzuki Castle, is the property of SageofDespair.
The Hōzuki Castle (鬼灯城, Hōzuki-jō; ; Literally meaning "Demon Lantern Castle"; ), also known as the Blood Prison (ブラッド・プリズン, Buraddo Purizun; ; ; ), is a large castle that serves as a criminal containment facility located in Kusagakure that appears in Naruto the Movie: Blood Prison. Its master (主, aruji; ; ; ) was Mui, who used the ultimate imprisonment technique to seal the abilities of his prisoners, preventing them from escaping.
The castle is situated near a cliff, where beneath is a raging ocean with tremendous currents that will wash up any attempt escapees and drown them. This, along with the imprisonment technique threatening to reduce anyone who reaches a certain distance from Mui to ashes, makes escape virtually impossible. The prison has no regard of the prisoners' circumstances of being sent there, and outside of the convicts' death, allows them to leave only if the village of the prisoner in question sends an official request for release. Apparently, the prison only admits male prisoners, as Ryūzetsu had to disguise herself as a man in order to infiltrate it.
Deep under the castle is an underground laboratory, which is connected to Mui's office at the top of the castle via a stairway hidden behind a bookcase. Inside is where the Box of Ultimate Bliss resides, embedded as part of a wall, which led others to believe it to be a gateway to the box instead; when the box is to be opened, it will rise to the outside garden of the castle. The lab contains various electronics that fit the stereotypical representation of a mad scientist's laboratory, including a table where a sacrifice to open the Box can be strapped down to and restrained.
While the prison was built under the appearance of holding dangerous criminals, in truth it was for Kusagakure to hide the Box of Ultimate Bliss and use the prisoners, who are no longer being cared for by the villages they originated from, as test subjects by having their chakra sucked out in the lab in an attempt to open the box.
Aside from the imprisonment technique and the lethal whirlpools surrounding the fortress, the castle itself has certain death traps set up in case prisoners attempt to escape. Also, prisoners usually tried to prevent trouble, resulting in an usually quiet and calm environment. Most likely due to these factors, the security is lax, if not outright incompetent, as even though the guards performed strip and body cavity searches, Naruto managed to sneak in a pair of shuriken with wires that saved him from a pitfall trap, and Ryūzetsu managed to hide her gender. Furthermore, in the cases where riots are induced, the guards were incapable of restraining the prisoners, and instead relied on Mui's technique to keep them in check.
Prisoners are let out from morning to sunset for daily exercise and meals, and at the end of the day they are instructed to return to their cells for sleep. Regulation 23 states that attempt escapes or troublemakers result in three days in solitary confinement in the disciplinary cell; clause 6 states second time offenders get five days, third time is a week, and a fourth is permanent.
Plot Overview
Naruto Uzumaki was sent here after being falsely accused of attempting to assassinate the Fourth Raikage, and killing jōnin from both Kirigakure and Iwagakure. This was all part of Mui's plot in order to use the Nine-Tails' chakra to open the Box of Ultimate Bliss to release his son Muku. Several prisoners, such as Ryūzetsu and Maroi, were in fact sent in as spies to prevent Mui from opening the box again. Ultimately, they failed to prevent that, and when Muku came out, he was corrupted by the box's powers and served as Satori's host. After a brutal battle, Muku and Mui died together, and the prison castle was burned down. The prisoners, being freed from Mui's imprisonment technique, attempted to escape but were recaptured by the Konoha 11. Mui and Ryūzetsu's bodies were buried outside the castle, while the box was cast into the ocean of the island.
- The castle is surrounded by the hōzuki plant, also known as Japanese lantern. In Japan, its seeds are used as part of the Bon Festival as offerings to guide the souls of the deceased.
- The sculpture behind the security desk is the Ecstasy of Saint Theresa by Bernini, which illustrates a moment where divinity intrudes on an earthly body.
- The movie claims Hōzukijō is located in Kusagakure. However, it shows that the castle is located on a cliff, by the ocean. Kusagakure is landlocked by four other countries; the Land of Fire, the Land of Earth, and the two unnamed countries where Amegakure and Takigakure are located, and as such, has no access to the ocean.
- The concept of the Hōzuki Castle's terrain is similar to Alcatraz, which is also situated near a cliff with a raging ocean beneath.


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Balance is a group effort of the eyes, inner ear, joints, and muscles. They each send signals to the brain about body position and head movement. The brain uses this information to balance the body. When an inner ear problem exists, the brain may receive conflicting signals. This can cause symptoms such as vertigo (spinning).
Inside the inner ear are three semicircular canals. Each canal contains tiny hairs, crystals, and fluid. These structures help the canals sense up-and-down, forward and backward, and side-to-side motion. Nerves carry the signals from the canals to the brain.
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When I was looking at colleges, I knew that I wanted a Christian college with challenging academics. Grove City College stood out because of its reputable engineering program.
I have always enjoyed math and science, but I particularly love engineering because it allows me to apply the principles of those disciplines towards creating something new and beneficial for society. Consequently, I plan on choosing a career path that will allow me to create innovative products and processes to help developing countries. This is my life's pursuit because I want to use the intellectual gifts God has given me to spread his love in a practical and tangible way.
While at Grove City College, I have been particularly impressed with my professors. Their consistent willingness to help shows their desire for students to succeed. For example, Dr. Clauss makes the classroom environment feel like her living room. She always opens class by interacting with her students on a personal level. She knows all of us by name and remembers the small things happening in our lives. She has personally helped me many times in past semesters, whether it be school related or simply being there as someone to talk to.
Overall though, my favorite part about mechanical engineering at Grove City College has to be the tight-knit community. Since our class sizes are small, we have become a family within our major, creating relationships that extend past just studying together. Some of my closest friends on campus are engineers, which isn't due to a lack of social life. We just truly enjoy each other's company.


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The NumberRiddles are little poems or phrases that pose a question that needs answering. Riddles frequently rhyme, but this is not a requirement.
I am 1, but not 2. I am 3, but not 4. Whenever I am dancing, one will be on the sidelines. I like to play leap frog on a number line. What am I?
AnswerAn odd number
What Next?
See another brain teaser just like this one...
Or, just get a random brain teaser
If you become a registered user you can vote on this riddle, keep track of
which ones you have seen, and even make your own.
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quote:Originally posted by Guest8977Detroit sucks--------------------------------------------------------------------------------So do the Flames, Leafs, Canucks, Coyotes, and Blackhawks according to you. Is there a team you think doesn't suck??
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Acer C7 Chromebook Reviewby Jason Inofuentes on 1/21/2013 12:30 PM EST
63 Comments
Back to Article
Jhlot - Monday, January 21, 2013 - linkCan I put windows on it if I have a copy? Are there drivers from the network/wifi, sound, etc..? It is also listing over $199 at Amazon now but Best Buy has it for $199 http://bit.ly/13ZhP37 Reply
andrewaggb - Monday, January 21, 2013 - linklol, kinda what I was thinking. Can I install Centos 6 on this thing? Reply
owned66 - Monday, January 21, 2013 - link1. a 100Mbps ethernet port (could used usb nics but...)
2. low end wireless card
it uses a custom bios that wont let u install ANYTHING else
heard some ways to circumvent it Reply
cyrusfox - Monday, January 21, 2013 - linkNeed a new bios to run windows (but at 800 MHz, it would be pretty anemic)
ChrUbuntu will work though Reply
StevoLincolnite - Tuesday, January 22, 2013 - linkYeah the performance would be Anemic.
But, again. Faster than Intel Atom and ARM, but then again you wouldn't be buying a device such as this to play Crysis and the Dual-Core 800mhz Sandy Bridge chip would still be a crap-ton better than Atom powered netbooks. Reply
Flying Goat - Tuesday, January 22, 2013 - linkDon't quote me on this, but my understanding is that all ChromeOS devices have a developer switch that will unlock the system, but it will delete all current user data when flipped. Reply
schizoide - Monday, January 21, 2013 - linkForget about windows, has anyone tried making a hackintosh out of it? At $299 it's got to be seriously commodity hardware, seems like it might be possible. Reply
schizoide - Monday, January 21, 2013 - linkErr, $199. Reply
N4g4rok - Monday, January 21, 2013 - link"I wanted to really dislike this experience, and in many ways it was comrpomised"
First line after the conclusion header. Reply
JasonInofuentes - Monday, January 21, 2013 - linkFixed. Thanks. Reply
Andrew911tt - Monday, January 21, 2013 - linkThe people who read this site would never buy this as a replacement for their main device so there is no need to look at how your daily work flow would not work on this device and make it go cry in the corner.
People are looking at this as a second device. I have a great desktop with two monitors and all the bells and whistles if I need to get work done. My second device is a old dell laptop that use in front of the couch or in bed that is the device that this was meant to be/replace. Reply
StormyParis - Monday, January 21, 2013 - linkThe people who read this site act as advisers for many people who might want/need such a machine as a primary PC. Reply
Andrew911tt - Monday, January 21, 2013 - linkAnd any person who would consider this as a primary machine don't have that type of work flow Reply
phillyry - Monday, January 21, 2013 - linkI'd have to agree with StormyParis.
I've actually been considering getting one of these things for my dad as a primary PC simply because he could still check his mail and do his banking while, at the same time, it would be difficult for him to mess it up.
So, let's not make too many assumptions about the readers. We don't all fit your personal usage style or preconceptions. Reply
Andrew911tt - Monday, January 21, 2013 - linkYou are making my point the person who ends up with it is going to be using it very sparingly. Your dad is not going to have the work flow that is described in the article, if would be much more facebook and email. Reply
JasonInofuentes - Monday, January 21, 2013 - linkSo, I think you'd be surprised how many writers see the appeal of the Chromebook. Writing is often a matter of focus. Eliminate distractions and pull together only the resources you need to get the job done. Browser-based publishing tools are polished enough that several of us are actually using them exclusively, including some that even do image manipulations entirely in the browser.
So, the Chromebook as a primary device has a lot of appeal.
What I was trying to make clear is how it falters despite having plenty of potential. I have no doubt that as the performance of Chromebooks improves, and as browser-based publishing and media tools become more capable, that I could move to a Chromebook as a primary writing device. I'd still need a better equipped device for a lot of the benchmarking we do, but it'd very much end up being the second device. Reply
jabber - Tuesday, January 22, 2013 - linkI have the Samsung on order to test out and have just bought a Business Google Apps account.
I have been talking to a lot of the folks in my small business networking circle and they are really interested in it.
All they need is basic word processing and spreadsheet capability. A group calendar and scheduling. All the documents backed up and centrally stored. Pretty perfect for a lot of small businesses.
That and the cost per user is £2.75 a month! If you have a lot of temp staff passing through you just give them a standard App account and then reset the password when they leave.
That and the lack of virus, not having to buy Office and the low cost of the locked down kit. Support costs are lower.
For a lot of businesses its a no-brainer. Reply
Alexvrb - Monday, January 21, 2013 - linkCorrection: Any person who would consider this as a primary machine doesn't have ANY work flow. Flow sure, but work not so much.
You said it yourself, people are looking at this as a second device to complement a real computer. But at that point, I think most people would be happier with a tablet as a second device. Reply
silverblue - Tuesday, January 22, 2013 - linkWhat if you were a author and wanted something cheap and not too small? Reply
silverblue - Tuesday, January 22, 2013 - link'an', rather... I did put writer before, hence the 'a'. Reply
s44 - Monday, January 21, 2013 - linkAs a second device, this is terrible. Active cooling, mechanical storage, total crap battery...
No way should anyone buy this over the ARM Samsung. Reply
lwatcdr - Monday, January 21, 2013 - linkActually I can see a lot of people using this as their only computer. If you do not game then this is ideal for a good number of home users. Thing of what a lot of home users do.
1. Facebook,
2. Amazon.
3 Banking/investments.
4. Email.
5. Netflix.
6. YouTube.
7. Pandora.
8 if a student writing papers.
Will it do Netflix? Doesn't netflix use .Net?
A lack of a spotify app could be an issue but then again RDIO doesn't need an app.
Google Docs is good enough for a lot of folks. With more and more moving to the web this really does make some sence for users. I would probably put Ubuntu on it but that is just me. Reply
tech6 - Monday, January 21, 2013 - linkThe problem with Chromebooks is the Chrome OS which is, at best, a Google side project. It's feels incomplete like an early beta release and the resulting compromises make it overpriced even at $200. Reply
sprockkets - Monday, January 21, 2013 - linkI guess the Nexus 10 review is permanently shelved... Reply
mayankleoboy1 - Monday, January 21, 2013 - link+1.
Still waiting for that. Reply
Death666Angel - Monday, January 21, 2013 - linkThe performance figures are really bad in my opinion. The A15 is dangerously close to the SNB Celeron. I am looking forward to more tests between those chips. And I wonder what the implications are for the 13W IVB/10W Haswell chips.
As for the laptop itself, it costs between 231€ (amazon.co.uk) and 269€ (.nl shop) in Europe, which means it competes with AMD E and C processor based notebooks (starting at 200€ without OS and 270€ / 300€ with full Win7/8 OS) and I don't see any advantage for this one. Reply
cosminmcm - Monday, January 21, 2013 - linkWhat performance are you talking about? This Celeron is the lowest SB can go, it has no HT, no turbo and works at 800 MHz. Anything at a higher frequency would make the difference enormous. And Ivy would only add to that and lower the power consumption.
An AMD E or C would be comparable to the Atom and lose to this Celeron too (800 MHz vs 1700 MHz). Reply
Death666Angel - Monday, January 21, 2013 - linkI didn't draw a performance comparison between the Celeron and the E and C AMDs, I only drew one between the A15 and the Celeron. Yes, it is the lowest one out there and it is clocked even lower. But considering that it is still a chip from Intel, done on a competitive and proven 32nm process with a 17W TDP, the performance delta over the A15 is pretty low in my opinion. And the 13W TDP IVB and low power Haswell chips will get there by significantly reducing clocks as well. I'm not saying it is slower, but considering everything Intel has over the other chips manufacturers, such a small lead is surprising to me. Reply
DanNeely - Monday, January 21, 2013 - linkCeleron chips are Intel's not quite worthless dies salvaged for whatever they can get away with selling them for. They've always had horrid performance/watt numbers. The fact that a near garbage grade 2 year old design is still competitive with the best that Arm has to offer says something completely different; as does Intel's 17W IVB chips being nominally upto ~4-7x faster (dual core, HT, and 1.9-2.8ghz). Chop that in half to look at a single core and you're at ~2.3.5x the performance for only marginally above the A15's max power; do the same with the 13W TDP part (1.5-2.4 ghz) ~2-3x performance at a slightly lower TDP. Reply
extide - Monday, January 21, 2013 - linkThat Celeron may be rated at 17w TDP, but I bet it doesnt even get CLOSE to that in reality. It's probably more in the 5-7W realm realistically. Think about it, 800Mhz, very little cache, no HT, no Turbo... Also considering that the Exynos 5 is running at up to 1.7Ghz, which is over twice the clockspeed, it firmly puts the performance differences into perspective. The Intel chip is straight up smoking that ARM chip. Reply
Spoelie - Tuesday, January 22, 2013 - linkmhz doesn't matter, it's just a function of architecture on a given process node.
With the celeron, you get 15% better cpu performance for 65% of the battery life, which is a pretty lousy showing imo.
On the other hand, at least the GPU is an improvement. Reply
madmilk - Wednesday, January 23, 2013 - linkMHz does matter. Sandy Bridge is not optimized to actively run at 800MHz - its sweet spot is around 3GHz. You pay a huge perf/watt penalty through leakage. An i7 doing the same tasks can go to sleep and power gate in 1/4 the time. Reply
BedfordTim - Monday, January 21, 2013 - linkAgreed. I was surprised how close the A15 was. Given the level of development that has gone into x86 processors, you would expect the code to be faster, and the gap should close with time. Reply
silverblue - Tuesday, January 22, 2013 - linkI think it could be the case that making an architectural change yields significant benefits, however after you while you'd end up like Intel, spending a huge amount of money to eke out a few more percent. I doubt that the next big step for ARM would be anything like A9 to A15 was. Reply
andrewaggb - Tuesday, January 22, 2013 - linkI know when I saw the benchmarks I had to go back and look at the x86 specs. For a second I thought the A15 was way faster than I expected. But then I saw just how crippled the celeron is and everything made sense... Reply
JasonInofuentes - Monday, January 21, 2013 - linkOthers pointed this out, but the take away from performance a performance standpoint is that if you take the second fastest x86 core designs in the market today, gut them, take out their legs, wrap a chain around their neck and put blinders on them, they're still faster than the fastest ARM Cortex-based SoC on the market today.
The big play with A15 is that they have finally reached IPC parity with small notebooks. And while that would have definitely been true 5 years ago when Atom was still fresh and Sandy Bridge was off the edge of Intel's road map slides, it is now not nearly so strong a case. In terms of performance/watt, ARM has done a very very good thing and they should be commended for that. And I have no doubt that a Chromebook equipped with Exynos 5 clocked at 2.3GHz would wipe the floor with the Acer C7. But we're still talking about putting a featherweight champion against a heavyweight punching bag.
We'll explore this relationship a little further, indeed you can get some feel of it in Anand's reviews of the Win8 tablets that have been coming out. Stay tuned. Reply
lmcd - Saturday, January 26, 2013 - linkHmm, but the graphics are an important point, and it seems like ARM (Mali-series) and Nvidia have a better roadmap there. Maybe a T4 Chromebook could take down an Ivy or Haswell ULP? Or an Exynos-Quad?
Worth seeing. Reply
bleh0 - Monday, January 21, 2013 - linkI'll wait till there is a reliable way to put Mint 14 on it. Until then you might as well put money towards the Samsung chromebook. Reply
mutatio - Monday, January 21, 2013 - linkNever mind the fact that this product, in similar fashion to the Droid phones, is designed entirely with the focus of mining, harvesting, and exploiting your personal data for their profit. No thank you, Google. Hell, I'll pay the Dell/HP "premium" of a $299 or $399 laptop/ultrabook to avoid that whole arrangement. Mind you, I've already happily paid the Apple premium to have devices focused on my ease of using them rather than the ease of which my information is exploited. Apple has a much better track record in respecting user's privacy, making the disclosure of it voluntary rather than inherent to the products being used. Reply
phillyry - Monday, January 21, 2013 - linkThat's a good point.
It really does seem like Google's dark side is starting to show now that they've got a death grip on the market.
It's like, "Mawahaha, now that we've got you in, we'll just monitor and monetize every aspect of your virtual life. Hahaha!" Reply
Spoelie - Tuesday, January 22, 2013 - linkThe exact same argument, without a word changed, can be made about Apple's approach to the market. Reply
BadCommand - Monday, January 21, 2013 - linkMaybe I missed it, but there is also the 100 gigs of google drive offered for 2 years for free w/purchase. If you use drive, that storage would be about $5/mo thereby making this device cost basically $80. Not bad. Reply
mike55 - Monday, January 21, 2013 - linkCoincidentally, I took a picture of the Chrome logo on a 13 inch 1280x800 LCD. It was on a much more expensive laptop, though. Here it is for comparison: http://i.imgur.com/qey7gUM.jpg Reply
evilspoons - Monday, January 21, 2013 - linkYou have a typo on your Display page - resolution reads 1136x768 when it should be 1366x768.
Otherwise - thanks for the review. I'm not sure if I'd want one of these, since my Nexus 7 does most of what you'd do with this device just fine, but I am going to keep these in mind for people who just want a web browser / "typewriter" out of a computer. Reply
JasonInofuentes - Monday, January 21, 2013 - linkFixed. Thanks. Reply
whyso - Monday, January 21, 2013 - linkWould be nice to have at least something other than browser tests. Reply
mayankleoboy1 - Monday, January 21, 2013 - linkEh ? But thats all what this Chromebook an do. Strictly browser stuff only. Reply
JasonInofuentes - Monday, January 21, 2013 - linkWe want to explore the relationship between the two Chromebooks further, but until then we can only do what will fit in a browser, since that's all we've got. Reply
lmcd - Saturday, January 26, 2013 - linkAre there any FOSS benchmarks you could recompile for NaCl? Reply
Exophase - Tuesday, January 22, 2013 - linkWhere/how was the 800MHz clock measured? Acer says that the model clocks at the full 1.1GHz:
http://us.acer.com/ac/en/US/content/model-datashee... Reply
JasonInofuentes - Tuesday, January 22, 2013 - linkIn the terminal I was able to run cat /proc/cpuinfo during lots of scenarios and the output was always 800MHz. Since there's no way to run monitoring programs in a Chrome OS instance, and since the clock and voltage tables aren't exposed as they were in the Samsung Chromebook, we don't know whether this is an intermediate state, but based on the results I'm confident of that figure as the max clock. Reply
Exophase - Tuesday, January 22, 2013 - linkAre you sure it said 800MHz for both cores? Can you test it while running a workload you know is pegging the CPU indefinitely, preferably a backgrounded command line task like dd?
Frankly I think the scores don't really add up for 800MHz. Look at what the lower end Samsung Chromebox achieves here:
That uses a Celeron B840 which is clocked at 1.9GHz, and since it isn't running on a battery they'd have no reason to underclock it. If you scale its Sunspider score of 296ms from 1.9GHz to 1.1GHz you get 511ms, which fits perfectly with the values you got in this review. At 800MHz you would expect a number closer to 700ms. This is assuming linear scaling, but given Sunspider is single threaded and these are fairly low clocks for both I doubt you'd get much worse. I also doubt that V8 made huge improvements in its x86 performance since then. Reply
sonnyrao - Sunday, January 27, 2013 - linkHi, it is definitely a 1.1Ghz processor, but has cpu frequency scaling enabled like any other modern system. I'm not sure what scenarios you ran but looking at /proc/cpuinfo isn't really the best way to determine frequency. At the minmum, you should be looking at /sys/devices/system/cpu/cpu*/cpufreq/scaling_cur_freq
but running something like powertop or i7z would be even better (you can copy them onto the C7 from another 32-bit Linux system)
I'd do something like this, put it into dev mode, open a window for crosh (ctrl-alt-t) and run the shell from there sudo to become root
then run
watch -d cat /sys/devices/system/cpu*/cpufreq/scaling_cur_freq
and then run your benchmarks in another window. Reply
jabber - Tuesday, January 22, 2013 - linkI've been trying out Lenovo Q180 Nettops recently. The ones I've been rolling out have the top end 2.1Ghz Atom in them, with 4GB of ram and a HD6450 GPU in them.
Tally this together with a Sandisk Extreme 120GB SSD and the computing experience is pretty good. In all the usual computing tasks I couldn't tell it was an Atom based machine. It felt as fast and fluid as any full size x86 PC I have around. I've rolled a few of them out to small businesses and feedback has been excellent.
The problem with Atom is that makers feel they have an excuse to pair them up with even crappier hardware. Throw in an Atom chip with some decent supporting hardware and you have a pretty good low power setup. Reply
lmcd - Saturday, January 26, 2013 - linkThe graphics tied with Atom are probably the most hindering aspect. Reply
max347 - Tuesday, January 22, 2013 - linkGreat review!
I think the pics could use a little less bokeh though :-) Reply
nathanddrews - Tuesday, January 22, 2013 - linkLOL - first thing I thought of. DOF is cool, but not if you can't even tell what's on the IO panel. Reply
JasonInofuentes - Wednesday, January 23, 2013 - linkFair enough, I'm trying to get a nice light set-up that would facilitate more bokeh-free shots, but in the meanwhile I'm generally just trying to keep people from seeing the mess my house is generally in. :) Thanks for the compliment.
Jason Reply
Notmyusualid - Wednesday, January 23, 2013 - linkAnd it was so dog dam slow, that I GAVE IT AWAY, as soon as I got back from my deployment in the USA.
Really, it gave me chest pains waiting for it to do anything.
I tried upgrading the RAM, and that made very little difference.
I realised quickly that I was wasting my time.
The 10yr old niece was happy to receive it though.... Reply
dj christian - Thursday, January 24, 2013 - linkJustin where did Anand cover the Chrome OS? It would be nice if you could provide us with a link to it.
Thanks! Reply
asa.bender - Sunday, February 17, 2013 - link"So are their any deficits to using the Dev build?" -> "...there..." Reply
Cumbey - Monday, February 18, 2013 - linkThe 20 second bootup and log in time greatly beats my Windows and Mac based computers. The price was more than right. The 320 hard drive storage "covers a multitude of sins", if any there be. I think both Google and Acer got it more than right this time! Thanks to both! Reply
xa3phod - Saturday, March 23, 2013 - linkHey folks. Quick question...if this is your only computer, how do you print? Does it work with network connected printers? Or can you USB connect it to a printer? Reply


text: Lady Gaga released her video finally for the single "Born this Way" and in true Gaga form, it's a mini-epic of a vid. She starts with a spaced-out monologue that's laid over imagery recalling Xanadu, a lot of The Jacksons' "Can You Feel It," Dante's Inferno, some Jem and probably many of the trips Charlie Sheen has in his head lately. With skeleton people, singing mannequin heads, kaleidoscopic images and the birth of a big ball of light, Gaga grabs all the attention she can in this seven-minute vid. The dancing is a bit rough and all over the place, but she knows how to keep your eye on the screen.


text:
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1 pound Shrimps (31-40 counts), shelled and deveined
1/4 pound ground pork
1 (14 oz) Won Ton Wraps
1/4 cup bamboo shoot, strips
Bok Choy
Green Onions, chopped
A few cups of seafood or chicken stocks
A dash of sesame oil
A pinch of ground white pepper
A package of fresh egg noodles
Marinade Ingredients
1 egg
1 teaspoon Shao Hsing Rice Cooking Wine
1 teaspoon fish sauce
2 teaspoon soy sauce
A pinch of ground white pepper
A dash of sesame seed oil
1/2 teaspoon corn starch
1/2 teaspoon sugar
1/4 teaspoon kosher salt (more or less adjust to taste)
To Make the Won Ton Fillings:
Cut shrimps into thirds or fourths depending on their size. In a large mixing bowl, add shrimps, ground pork, bamboo shoots and all marinade ingredients together. Stir until well combined and marinade is evenly distributed.
Slightly dust a large sheet pan with all purpose flour, set aside. Fill a small bowl with tap water, set aside. Spoon a heaping teaspoonful of won ton filling onto the center of a piece of won ton wrap. Dip finger into prepared water and wet all the edges of the won ton wrap. Fold a corner of the wrap to the opposite side to form a triangle. Gently press the sides of the wrap to seal the edges. Pick up the two corners of the filled won ton, wet the tips and press them together. Place onto prepared sheet pan. Continue to fill won ton wraps until all fillings are used up.
To Prepare the Won Ton Soup:
In a medium stock pot, bring water to a boil. Cook the noodles according to the package. Usually just 2 to 3 minutes. Do not over cook the noodles as they are fresh noodles, which cooks up much faster than dried noodles. Use a pair of chopsticks or tongs to move the noodles around when they're cooking. Remove noodles from heat and into serving bowls.
Wait until water return to a boil before dropping the won tons in. Add won tons and cook until the water re-boil again. When the won tons flow onto the top, they're ready. (Keep in mind, if your won tons are frozen, it might take a few more minutes to cook up). Remove from water and divide them into serving bowls.
In a separate pot, heat your favorite seafood or chicken stock until boil. Add bok choy and cook for a few minutes, remove to serving bowls. Ladle stock into serving bowls, sprinkle with green onion, a splash of sesame oil, ground white pepper and serve. It's wonderful with a few drops of chili oil/chili sauce as well.
© 2017 Cuisinart. All Rights Reserved.
© 2017 Cuisinart. All Rights Reserved.