text:
The treatment of immunobullous diseases consists of three phases:
- Control: period of intense therapy given to suppress disease activity until no new lesions appear. The duration of this phase is weeks.
- Consolidation: Drugs and doses are maintained until complete clearance of lesions.
- Maintenance: Medications can be gradually tapered aiming for the lowest dose that prevents new lesions from appearing.
- Relapse may occur at any time, resulting in renewed disease control effort. (z).
The main focus of treatment has been medications with potent anti-inflammatory properties (corticosteroids) as well as medications that reduce antibody production.
The drugs used for treating immunobullous disorders can be classified into rapid and slow acting (see Table below), topical and systemic, or immunosuppressant and anti-inflammatory.
Pemphigus Vulgaris
Pemphigus is a particularly difficult disease to treat. Anti-desmoglein antibodies are produced in all forms of pemphigus. These antibodies bind to adhesion molecules on the epithelial cell surface, which leads to separation of keratinocytes from each other and to blister formation. The exact mechanism by which this occurs is uncertain but likely involves inflammatory pathways triggered by binding of antibodies to the adhesion molecules. Therefore, therapy is intended to reduce the production of pathogenic antibodies and to inhibit the other pathways involved in the disease process (aa). It is unclear at this time, whether drug therapy's effect on reducing autoantibody synthesis is more or less significant than the effect of decreasing the inflammatory response
A recent analysis of therapeutic approach identified the following patterns and opportunities for improving care:
- Early expert evaluation: as "the long delay from onset of symptoms to expert evaluation is quite striking". In PV, similarly to other autoimmune diseases, if the process is not promptly and appropriately controlled, the disease becomes more resistant, making the condition more difficult to treat.
- Confirmation of the clinical diagnosis: by tissue biopsy specimen for histopathologic and both indirect and direct immunofluorescence examination.
- Although still under evaluation, consideration of early adjuvant immunosuppression in moderate and severe cases: e.g. azathioprine or mycophenolate mofetil.
- Review of the length of adjuvant immunosuppressant use: The vast majority (82%) of experts use adjuvant immunosuppressants for 2 years or less (bb).
Pediatric pemphigus vulgaris maybe more refractory to treatment than the adult form. (aa)
Systemic corticosteroids are the best established therapy for the management of PV. If used in high enough doses, they rapidly control of disease activity is achieved in almost all patients, resulting in decreased mortality (o, e).
Initial Therapy
Initial therapy is determined by the extent and rate of the progression of lesions. Localized, slowly progressive disease can be treated with intralesional injections of corticosteroids (triamcinolone acetonide, 10 to 20 mg/ml) or topical application of high-potency corticosteroids (o). New lesions that continue to appear in a limited number may be controlled with low-dose systemic corticosteroids (b).
If the disease fails to respond to the measures above, or is extensive or progressing rapidly when first seen, then it is generally treated with high-doses of systemic steroids (prednisolone, prednisone, methylprednisolone, dexamethasone), orally or by IV. The doses required will vary depending on the activity and severity of the disease and can range from 1 to 2 mg/kg/day of prednisone equivalents, often in split daily doses initially.
Formally, when no alternate therapeutic approaches were available, doses over 250 mg/day of prednisone were sometimes required to control the disease. Now that alternates approaches are available, if the disease remains active despite high doses of corticosteroids (e.g., 90 to 120 mg/day of prednisone equivalent), one of the following approaches could be considered for rapid control (o):
- Use of an immunosuppressant (added to the glucocorticoids).
- If the disease is unresponsive or particularly severe, IVIG or plasmapheresis may be used.
- The use of corticosteroids and immunosuppressives prior to IVIG or plasmapheresis may help to prevent rebound phenomena that may otherwise occur (o) due to an increase in level of pemphigus antibodies.
- Intravenous immunoglobulin (IVIg), usually given at a dosage of 400 mg/kg/day for 5 days or in higher doses for 3 days. The procedure may need to be repeated every 4 weeks for several cycles. It is very expensive. The use of IVIg for the treatment of skin diseases has recently been reviewed.
- Plasmapheresis, normally performed three times a week, involves removal of 1 to 2 L of plasma per procedure. This procedure is being replaced by IVIg, which can reduce circulating levels of pemphigus antibodies almost as rapidly and may be safer.
- Pulse therapy with mega doses of intravenous methylprednisolone, given at a dosage of 1 g/day for 5 days.
- (The TNF-a inhibitors such especially Rituximab are currently being investigated for efficacy in the treatment of Pemphigus Vulgaris).
No comparative studies have yet evaluated the relative effectiveness of these procedures (o). Once disease activity is controlled, the patient is maintained on the type and dose of medications required to establish control until approximately 80% of lesions are healed. Therapy should not be tapered while new lesions are appearing. (b)
Maintenance Therapy
Once most lesions have healed, the dose and type of medication that controlled disease activity are gradually tapered to reduce the risk of side effects. This is important since most patients who die today with pemphigus die due to complications of therapy (e). The rate of dose reduction is an art, determined by clinical response and disease activity. (o).
Systemic steroids are the mainstay of therapy, but longer-term treatment and higher doses often causes significant side effects: therefore consider:
- Screening and risk assessment of possible side effects e.g. diabetes, glaucoma, osteoporosis, hypertension, GI bleeding, hyperlipidemia, tuberculosis is required prior to and during treatment.
- The use of adjuvant therapies, which may help reduce the steroid dose, limit side effects and still control disease (o).
- Adjuvant therapies include various immunosuppressive drugs (see below) and anti-inflammatory drugs such as gold, dapsone, and antibiotics such as tetracycline and minocycline.
- It is recommended to give concomitant calcium and vitamin D (non-activated) supplements to all patients on corticosteroids.
- It is recommended to give bisphosphonates to all patients (e.g. most male and post-menopausal) on long term steroids, unless contra-indicated (e.g. premenopausal women anticipating pregnancy in the future) – see section on management later.
A recent study of prescribing practices from academic and tertiary care centers
indicated that initial steroid dose ranged from 1 – 1.5mg/kg/d (q).
Long-term dosing approaches varied as follows:
- 37% of physicians polled stated that their goal is to eliminate corticosteroids completely; 11% had a goal of an alternate daily prednisone dose of 5 mg;
- 26% were comfortable with a dose of 5 mg/d; and 26% were satisfied with 10 mg/d.
- Immunosuppressants: (as adjuvant medications)
Depending upon the response and or tolerance of medication, adjuvant (immunosuppressive) therapy may be substituted or added to corticosteroid therapy, in an attempt to spare or reduce prednisone dose and its associated complications (i). Very few controlled studies of adjuvants have been done, so that their effectiveness remains uncertain, as does their relative safety.
In a recent review of prescribing practices (q) Azathioprine was the most frequently used adjuvant immunosuppressant, then Mycophenolate mofetil (CellCept®), cyclophosphamide, and cyclosporine in that order. Forty-six percent of respondents in that review reported they maintain steroid-sparing immunosuppressants in their patients for 6 months to 1 year, whereas 36% continue the immunosuppressants for 1 to 2 years, and 18% maintain this regimen indefinitely.
There are a number of clinical trials underway to better evaluate these adjuvant therapies (e).
Azathioprine is a well-established choice as an adjuvant drug for the management of pemphigus (i). Typical dosage is 2.5 mg/kg/day. It is believed (but not proven) to have a steroid sparing effect, and may reduce mortality and increased remissions versus corticosteroids alone (c).
Azathioprine should be titrated to TPMT activity (i) (Azathioprine is best avoided in patients with very low TPMT levels (which exists in 1: 200-300 of the general population (d), and should be used at reduced doses, e.g. 0.5 mg kg-1, in those with low levels (~ 10%). This group is particularly at risk for bone marrow suppression and thus anemia, thrombocytopenia, and leucopenia (x). TPMT is an enzyme that converts azathioprine into its inactive metabolites Patients with high levels (~ 10%) are at risk of under-treatment using standard doses. Other side effects of this drug include abnormal liver function tests, nausea, hypersensitivity reactions and increased susceptibility to infection.
The dose should be titrated upwards according to clinical response and side-effects, and doses up to 3.5-4 mg kg-1 may be required. Monitoring includes a CBC and platelet count every 1-2 weeks with changes in dosage, and every 1-3 months thereafter
Mycophenolate mofetil
Mycophenolate mofetil is safe and effective for adjuvant treatment for pemphigus. MFM is an ethylester of mycophenolic acid which is metabolized to the active drug mycophenolic acid (MPA). MPA is a product of several Penicillium species. This immunomodulatory drug selectively inhibits inosine monophosphate dehydrogenase (IMPDH) in the denovo pathway of purine synthesis (cc).
Total daily doses of 2–3.5 g (depending on body weight) are typically given in two divided doses with glucocorticoids (i). It is believed to have a glucocorticoid-sparing effect. At usual doses, MMF is generally well tolerated. Compared to other immunosuppressants, such as methotrexate, azathioprine and cyclosporine, the relative lack of hepatonephrotoxicity with MMF offers an important therapeutic advantage.
The most common side-effects are gastrointestinal (i.e., nausea, diarrhea, abdominal cramps, constipation, vomiting and anorexia) and genitourinary (i.e., urgency, frequency, dysuria, hematuria and, occasionally, sterile pyuria). These occur in up to 36% and 40% of patients, respectively (dd). Also lymphopenia, anemia, thrombocytopenia, and increased risk of opportunistic infections.
Remission rates of about 70% in patients with pemphigus vulgaris and 45% in patients with pemphigus foliaceus, with a median time to achieve complete remission of nine months (range, 1-13 months) demonstrated at higher doses of about 35-45 mg/kg/day have been reported (ee).
Like most other therapies, there have been no controlled trials of Methotrexate in Pemphigus (e). Case series suggest 10-25mg/week usually in combination with prednisone may be helpful. Methotrexate may have a glucocorticoid-sparing effect. Recent studies have shown low-dose methotrexate (up to 15 mg weekly), as monotherapy or adjunctive therapy, to be efficacious in bullous pemphigoid (x) which should only be used if other more established therapies are exhausted. Side effects include hepatic fibrosis, cirrhosis, pulmonary infiltrates or fibrosis, nausea/vomiting, and lymph node swelling. Screening for hepatitis prior to initiation of therapy is recommended. Monitoring includes CBC, platelet count, AST, albumin, creatinine every 4-8 weeks (eee).
Oral cyclophosphamide can be considered an alternative to azathioprine.
It is believed to have a glucocorticoid-sparing effect, and some cases of prolonged remission have been documented (i). The dose used is 1-3mg/kg/day.
Cyclophosphamide is a potent cytotoxic agent which can cause severe cytopenia and hemorrhagic cystitis (bladder inflammation). Because of these potential toxicities, the drug should be reserved for patients who don't respond to other immunosuppressives.
Other side effects include neutropenia, alopecia, GI disturbances, raised transaminases, thrombocytopenia, and secondary infertility (i).
Recommended monitoring includes a CBC and platelet count every 1-2 weeks with changes in dosage, and every 1-3 months thereafter, with urinalysis and urine cytology every 6-12 months after cessation (eee).
Chlorambucil is an alkylating agent of the nitrogen mustard group of chemotherapeutics which works by binding DNA strands and preventing its replication.
Chlorambucil orally at 4 mg day and titrated upwards according to clinical response could be considered as an adjuvant drug if more established options cannot be used, but there are limited data to support its use (i). Side effects include myelosuppression and monitoring includes CBC and platelet count every 1-2 weeks with changes in dosage, and every 1-3 months thereafter (eee).
IVIG treatment is still experimental, although it seems to be effective for the initial suppression of the condition in some patients. The actual degree and length of effectiveness and the optimum dosages and intervals are still being determined. There has been increasing use and interest in early use of IVIG, which has been reported in some patients to rapidly control active PV. IVIG selectively and rapidly decreases circulating pathogenic autoantibodies in PV when combined with other treatments, such as prednisone, and immunosuppressives (jj,ll), although more evaluation of such combinations is necessary). Adequate and frequent medical supervision of treatment is necessary (kk).
IVIG is given through an IV line, each cycle lasting up to 5 days, at a dose of 1 to 2 g/kg per cycle. Several cycles are usually required. Cost and availability of this agent limits its use.
Repeat courses can be considered as an adjuvant, maintenance agent in recalcitrant disease, where more conventional therapies have failed or cannot be used.
For autoimmune bullous disease the recommended guidelines for IVIg are as follows:
- Failure of conventional therapy;
- Significant adverse effects from conventional therapy;
- Contraindications, relative or absolute, to the use of high-dose long-term systemic therapy;
- Progressive disease despite conventional therapy;
- Uncontrolled, rapid debilitating disease (mm).
Plasmapheresis: is recommended for disease suppression in severe recalcitrant disease. Plasmapheresis is extracorporeal treatment which acts rapidly on disease activity by lowering the load of the causative auto-antibodies in the patient's circulation. IVIG seems to work similarly but is safer. It should be used only in conjunction with other immunosuppression, since there can otherwise be rebound of autoantibody production. A variant therapy, immunoadsorption (IA) has been tried effectively in a case study as adjuvant therapy in pemphigus (nn).
Other Drugs
5mg/kg/day. This is one of the few drugs that has been studied in randomized trials, in which it did not show effectiveness, and is therefore not recommended as an adjuvant therapy on the basis of increased morbidity and mortality rates. The use of cyclosporine is limited by its toxicity, especially hypertension and dose-related loss of renal function. The loss of renal function with cyclosporine appears to be largely, but not entirely, reversible with discontinuation of the drug. Many medications may increase cyclosporine levels and thus increase the risk of nephrotoxicity. Therefore, cyclosporine treatment is primarily confined to patients with refractory disease (oo)
Anti-inflammatory agents
Anti-inflammatory agents such as dapsone, tetracyclines, and gold are used as they also may have a steroid sparing effect in mild to moderate disease (e), often in patients who are in maintenance phase but corticosteroid-dependent. Dapsone is a first-line treatment in dermatitis herpetiformis, linear IgA disease, and milder cases of pemphigus foliaceus:
Dapsone must be started after glucose-6-P-dehydrogenase screening and is administered as 7.5mg/kg/day, up to 200mg/day.
Gold may also have a steroid sparing effect. It is not commonly used because of side effects (proteinuria, nephritic syndrome, dermatitis, urticaria etc. (e). It is administered as 50 mg IM injections of gold thiomalate or as the oral form auronafin.
Tetracycline antibiotics
Tetracycline, doxycycline and minocycline have been used by some in glucocorticoid-dependent patients in the maintenance phase of therapy, often with niacinamide (nicotinamide). It is administered as tetracycline 2g/day and niacinamide 1.5g/day (in divided doses, or minocycline 100mg twice daily) and niacinamide 1.5g/day (in divided doses.
Cholinergic agonists
These can affect desmosomal adhesion, and acetylcholine seems involved in the acantholysis of pemphigus (e). It may be beneficial for some patients, but there are no completed trials to date. Examples are pyridostigmine bromide and pilocarpine.
Desmoglein 3 Peptides: A phase I clinical trial was completed.
Biologic agents
A variety of biological agents are being introduced in the management of pemphigus. The one with the most evidence suggestive of effectiveness is rituximab, as others have been used in too few patients to determine effectiveness (ff).
Rituximab, an anti-CD20 chimeric monoclonal antibody, is approved for use in non-Hodgkin lymphoma. It reduces circulating B cells and prevents their maturation into antibody-secreting plasma cells (o). However, there is a case report of partial remission from recalcitrant, life-threatening pemphigus vulgaris after treatment with rituximab (anti-CD20 antibody) and IVIG (gg). In another recent study (hh) the efficacy of rituximab for severe pemphigus was demonstrated when it achieved 86% complete remission 3 months after receiving four weekly infusions.
Administered as 375mg/m2, infusions over 4 wks. Some patients treated with this regimen contracted severe infections, one of which was fatal (o). In summary, a single cycle of rituximab has shown to be effective in pemphigus. Because of its potential severe side effects, its use should be limited to the most refractory disease. (hh)
The following drugs have been used in few patients and studied infrequently at this time:
Infliximab a chimeric IgG1 monoclonal anti-TNFa antibody (ii). It is usually administered at a dose 5 mg/kg, frequently in combination usually with MTX).
This drug's safety and efficacy in PV patients have not been established.
With infliximab (and etanercept – see later), caution should be exercised when considering the initiation of TNF inhibition in patients with an increased risk of infection (IDDM, CHF, renal insufficiency, debility, etc.) and should be avoided in those with active serious infections (e.g., sepsis, tuberculosis) or chronic and recurrent infections.
Patients starting infliximab (or any other TNF inhibitor) should have a PPD test and/or chest x-ray to check for underlying tuberculosis (TB). If there is underlying or inactive TB, anti-TB treatment should be added before starting infliximab.
Compared with etanercept, there is a higher risk of side effects with rituximab, including anaphylaxis, reactivation of tuberculosis, and the production of neutralizing autoantibodies.
Etanercept is a TNF-a inhibitor administered as 50 mg subcutaneous injection weekly. It is a chimeric fusion protein. It has not been approved for use in Pemphigus or Pemphigoid.
There are a number of side effects, including the development of autoantibodies in approximately 3% of patients, injection site reactions, and a concern about infections and autoimmune demyelination.
Adalimumab is another TNF-a inhibitor, and a fully human monoclonal antibody that has shown beneficial effect in Pemphigus in some limited case studies. It is administered as 40 mg biweekly. Also reported is concomitant use with mycophenolate mofetil (e).
Topical Therapy
PV is largely managed with systemic therapy but adjuvant topical therapy may be of additional benefit, although there are no controlled studies to confirm this.
Topical high potency steroid therapy may help reduce the requirement for systemic agents.
Intralesional injections have demonstrated efficacy.
There have been anecdotal reports concerning the treatment of pemphigus with topical tacrolimus as an adjunct. (e.g. 0.1% tacrolimus ointment twice daily for 3 to 4 weeks while continuing systemic immunosuppressive therapy, or 0.03% topical tacrolimus (applied twice daily) to the systemic regimen for ocular lesions) (pp).
For multiple oral erosions, 'corticosteroid mouthwashes are practical, for example, soluble betamethasone sodium phosphate 0.5 mg tablet dissolved in 10 mL water may be used up to four times daily, holding the solution in the mouth for about 5 min. Isolated oral erosions could be treated with application of triamcinolone acetonide 0.1% in adhesive paste or clobetasol 0.05% gel. Topical cyclosporine (100 mg/ m1) in oral pemphigus has been described and may be of some benefit but is expensive (qq).
Intralesional therapy with an injectable corticosteroid may be useful for the management of discrete lesions.
There are similarities in the management of BP and Pemphigus Vulgaris in that systemic steroids are the mainstay of therapy. In patients with extensive disease, other immunosuppressive agents, such as azathioprine, mycophenolate mofetil, and rarely cyclophosphamide, can be added as steroid-sparing agents. Unlike pemphigus however (rr),
- Bullous Pemphigoid normally, but not invariably, responds to lower doses of systemic corticosteroids (alone or combined with other oral or topical agents), with most patients improving on prednisone at a dosage of 80 mg/day or less;
- Topical corticosteroids (high potency) are commonly used for management of lesions.
- In an open prospective study of 18 cases, low-dose methotrexate was shown to be effective for maintenance of clinical remission induced by initial short-term use of potent topical steroids;
- Considering that the prognosis of untreated BP is better than that of pemphigus, side effects of treatment are of greater concern.
- Two small studies of severe ocular mucous membrane pemphigoid suggest that this condition responds more favorably to treatment with cyclophosphamide combined with prednisone, whereas dapsone suppresses some cases of mild to moderate disease.
General guidelines for therapy
Pemphigoid is a condition of the elderly who are more likely to be in poor health, much more susceptible to side effects, and may be taking multiple medications.
- Avoid aggressive non-validated treatments
- Objectives of treatment
- Control of itch and skin lesions
- Avoid serious side effects (mortality)
- Cost-effectiveness
Therapy algorithm (l)
- For Localized BP:
- Use potent topical steroids (validated). As elderly people have low tolerance for standard regimens of oral corticosteroids, a 2002 study (l) showed topical corticosteroid therapy is effective for both moderate and severe bullous pemphigoid (this would not be localized, so it is confusing to put this here) and is superior to oral corticosteroid therapy for extensive disease.
- For Extensive BP:
- Potent topical steroids (validated)
- Higher doses of oral steroids (validated) e.g. 0.75 mg/kg prednisone
- Combined treatments (not validated)
- Topical/Oral steroids plus systemic treatments e.g.
- Immunosuppresants: MTX, azathioprine, mycophenolate mofetil, cyclophosphamide, chlorambucil
- Other: Tetracycline and nicotinamide
- Routine use of immunosuppressive drugs has shown
- No additional benefit (no improvement in disease control, no reduction in doses of steroids)
- More severe complications
- IVIG: Potentially useful in reducing the doses of steroids used, but poor data
Pemphigoid Gestationis
The goals of treatment are to relieve pruritus and to suppress extensive blister formation, and to minimize the risk for the mother and fetus. The lowest effective dose of medication is used. Non-medical therapy includes tepid baths, compresses, and emollients. Topical therapies include antihistamines and topical or intralesional steroids, such as triamcinolone. In moderate to severe cases, systemic steroids remain the mainstay of therapy (typically prednisone 0.5 mg/kg/d). Limited experience with adjuvant or other immunosuppressive therapy exists (h).


text:
The Revel team is hiring! Developers, White Box Quality Engineers and Program Managers.
My organization is having a bit of a growth spurt and we're looking for good folks with a passion for Photography and making high-quality, easy-to-use software for desktop, tablets, phones and the web. Here are the positions we're looking to fill:
The Revel client team is looking to hire two senior computer scientists. This team is building the Revel client for desktop and mobile. You can find out more about the positions from this link and this link.
Prefer coding in Ruby to ObjC or C++? The Adobe Revel web services team is hiring both a computer scientist and white box quality engineer.
The Adobe Camera Raw team is looking for a talented engineer with a passion for photography. This image processing engine not only powers applications like Lightroom on the desktop, but also Revel on mobile, and is a major part of other products like Photoshop, Photoshop Elements and others.
Finally, we're also looking for an experienced Program Manager to work with me, the engineers, and our Product Managers.
If you are attending the Siggraph conference next week and would like to talk more about any of these positions, leave a comment here or send me a tweet and we can talk.
For more information, see http://www.adoberevel.com/.

subset: commoncrawl


text:
Topic: Barb "The Commander" at Home Hospice
Hi Barb.... Whether one night or a few months, your still with us and our hearts beat furiously for your comfort and ease of mind. You are a remarkable person full of love and unselflishness who deserves nothing less than triumph support full of respect and dignity. Although your in Ohio and I in Kansas, If anything comes to mind that I could possibally do for you to feather your journey; Well Commander you just give the order.
God Bless,
Jeff G.


text:
SAINT LEO, Fla. – The no.15-ranked Saint Leo women's tennis team, in the midst of a seven-match winning streak, fell to the no.2-ranked Embry-Riddle Eagles, 5-2, Saturday afternoon from the Saint Leo Tennis Center.
The match was the final regular season contest for the Lions and also marked the final home competitions for seniors Jeanette McDonald and Selma Hidass.
The Eagles, a perennial national championship contender at the NAIA level, used a doubles sweep of the Lions to propel them to the victory.
The Lions drew close to the Eagles in doubles and both top and three-flight doubles were on the wrong end of 8-5 decisions. Still, the Lions were able to mount a comeback in the singles session as both Emily Singleton and Maria Benkirane were able to collect wins at the no.2 and no.4 spots, respectively.
Singleton, ranked no.25 in the country, posted a convincing defeat of no.5 Rocio Frej Vitalle, 7-5, 6-0. Meanwhile, Benkirane left no doubt in her decision with Kristina Marova, 6-2, 6-1.
The women, who finished third in the Sunshine State Conference, will now begin preparations for the SSC Tournament which is scheduled to begin on Thursday, April 19, in Lakeland, Fla. Florida Southern College will act as host for the tournament. Opponents and times are yet to be determined.
For more on the nationally-ranked women's team, visit SaintLeoLions.com.


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Advocates are making the connection
Last week I had the opportunity to take the SAAM act on the road, and I was fortunate to be heading to one of my favorite places on the planet: Jersey. The great folks at the New Jersey Coalition Against Sexual Assault (NJCASA) host an ongoing training institute to educate and inform practitioners on sexual violence prevention and survivor-centered approaches. When NJCASA reached out to NSVRC and our partner Alison Bellavance from Planned Parenthood of Northeast, Mid-Penn & Bucks County, I was so excited to be returning to my home state to train on one of my favorite topics - healthy sexuality.
Our training focused on "Making the Connection" between healthy sexuality and sexual violence prevention. Alison's background as a sexuality educator and my experience in the anti-sexual violence movement really shape how we understand healthy sexuality and share this connection. Alison and I have had a few opportunities to co-present this topic, and it's always cool to be able to see advocates and educators begin to make or strengthen the connection between these fields and frameworks. I'll be honest, it's also just really fun to present on a topic that sells itself: good sex!
Connecting the dots
So how did advocates connect the dots? Our activities, discussion and dialogue connected that healthy sexuality bolstered sexual violence prevention in the following ways:
Healthy sexuality engages everyone. Sexuality is a part of each of us throughout the lifespan. Life enriching information and skills that support healthy sexuality are relevant to all of us at each stage of life. Sexuality is much more than sex, and all of us experience sexuality on emotional, social, cultural and physical levels.
Healthy sexuality challenges social norms. Many of us were not taught about sexuality in a comprehensive or life enriching way, but that doesn't mean society, media and corporations are not sharing messages about sex and sexuality. The problem is that these messages about sex are often negative and unhealthy. Healthy sexuality challenges these negative messages and critically examines the norms that create conditions where sexual violence is acceptable.
Healthy sexuality dismantles oppression. Healthy sexuality validates the many voices, experiences and differences that are silenced and oppressed in mainstream messages about sex and sexuality. Characteristics of positive sexuality include respecting the rights of others and treating all genders, sexual orientations and identities with respect. When sexuality is expressed in healthy ways this challenges attitudes that objectify, sexualize or silence populations based on gender, orientation, identity, race, age, ability, income, or other factors.
Healthy sexuality promotes self-care. A landscape of negative lesson, messages and values that often take center stage in society's discussion of sex hurts all of us. For those working to end sexual violence and those who have experienced sexual violence this can be even more difficult. Embracing, sharing and promoting a positive framework for sexuality can be incredibly healing. Not only can healthy sexuality strengthen our self-care through positive reframing, but we also have the opportunity to imagine and encourage a healthier future for all.
Healthy sexuality empowers us. Healthy sexuality is about the possibility and power of a positive alternative. It's about the potential for social change and a future that is free from sexual violence. On an individual level, it's the skills and behaviors that contribute to our wellbeing. But it's also about creating a climate and context where we all have a voice to challenge negative messages and set a higher standard for communities, institutions, media and society.
How do you connect the dots? Share a comment below telling us how you make the connection between healthy sexuality and sexual violence prevention.
Filed under
Posted by lpalumbo on 11/12/2012


text:
What Went Wrong with NV3x: A Moratoriumby Derek Wilson on 4/19/2004 4:12 PM EST
- Posted in
- GPUs
18 Comments
Back to Article
WizzBall - Tuesday, May 04, 2004 - linkNice article... sooo, when are we going to see the follow-up to this now that ATI came forward with their cards ? May I suggest 'What went wrong with NV4.x' ? :D Reply
TrogdorJW - Tuesday, April 27, 2004 - linkHey... anyone else having password issues, or is that something my company network admins f'ed up? I keep entering my password, but it doesn't get remembered. Ugh.... Reply
TrogdorJW - Tuesday, April 27, 2004 - linkPersonally, I think it's all about the alliteration: "The Pixel Pipe Performance Picture!" :)
Anyway, I imagine the moratorium will end once the R420 is released and we can talk about all four chips (R3xx, R4xx, NV3x, and NV4x), right? Yeah, that's it....
On a side note, I wonder how much going from FP24 to FP32 would cost ATI in terms of transistors, not to mention the Shader Model 3.0 stuff. It's not that we really need it, but going from 24-bit to 32-bit color basically makes everthing that operates on the data 25% larger in terms of transistor usage. Add in the other missing SM3.0 features, and I think a 160-180 million transistor R420 would suddenly become a 222 million transistor NV40. Basically, I think performance from the next generation cards will be about the same given the same GPU/VPU and RAM speeds. The only difference will be that NV4x has SM3.0 support, which looks to be a marketing point more than anything. Reply
greendonuts3 - Thursday, April 22, 2004 - linkthat's "Post-Mortem", as in "Post-Mortem Analysis" as in "Autopsy," not "Moratorium," as in "banzored."
Thank you very much.
And DON'T forget to hyphenate "Post-Mortem."
"Post Mortem" means "dead letter" or some such.
ianmills - Thursday, April 22, 2004 - linkthis article is crap. The real reason NV30 sucked is because nvidia slept with 3Dfx and got caught pixel herpes. Reply
TauCeti - Wednesday, April 21, 2004 - linkMoratorium:
> We have stopped -- we are done with NV3x analysis.
Well, if you have _stopped_ writing NV3X-content, it is _not_ a moratorium.
After a moratorium ends, you are obliged to continue with your _suspended_ activity.
Besides that: good article ;)
DerekWilson - Wednesday, April 21, 2004 - link#11:
We have stopped -- we are done with NV3x analysis. I'll admit that the title could have been phrased a bit better, but we did mean moratorium... Of all the articles I have written I think I've gotten the highest volume of emails on this one -- to tell me that I don't know what moratorium means ;-)
But on topic ... The big problem with an article like this (or any architectural or deeply technical article) is balancing depth, clarity, and length.
If you guys have any suggestions on balancing these aspects in another way, please let us know. We want to write the articles that you want to read! Reply
GomezAddams - Wednesday, April 21, 2004 - link"Can it not be a moratorium on NV3x articles?"
It will be when you stop writing them. ;)
I thought it was a pretty decent article too. I am looking forward to one that compares ATIs next contestant on these issues.
Personally, I can handle a lot more detail but I would prefer not to spend so much time reading articles. :)
Phiro - Wednesday, April 21, 2004 - linkMy earlier outburst aside, it's a very good article. Reply
DerekWilson - Wednesday, April 21, 2004 - linkCan it not be a moratorium on NV3x articles? I thought it was funny ;-)
fp16 vs fp32 and image quality is a very tough nut to crack. there are a lot of things going on on the side of compiler optimizations that we really need to look into in order to understand what's going on.
also, rotated vs. ordered grid has no performance difference. or it shouldn't anyway. we wanted to focus on performance in this article. Reply
PrinceGaz - Tuesday, April 20, 2004 - linkMaybe they've been saving this article up until after the NV40 was launched? I must admit I subconciously substituted postmortem myself when reading it.
Well put together article Derek, it clearly explains some of the problems that led to the entire GeForce FX (NV3x) range of cards always being in second-place behind equivalent R3xx cards (the NV34 core FX5200 had no R3xx based competitor).
I'm surprised no mention was made of the FP16/FP32 performance issue with the NV3x core and the consequences that is having on image quality, and also how its inferior ordered-grid anti-aliasing couldn't compare with the rotated-grid used in the R3xx. Reply
Phiro - Tuesday, April 20, 2004 - linkwahahahaa a "moratorium" hahaha
You guys need to quit looking up big words that sound like the word you really mean to use, and actually grow some vocabulary.
How about "postmortem"? Do you even know what the word "moratorium" means? Reply
Cybercat - Tuesday, April 20, 2004 - linkNice work, you made it user friendly, so even I can understand it! lol, when it comes to explaining graphics architectures to me, that's no small feat. Reply
newuser12 - Monday, April 19, 2004 - linkthis article is depressing, being as I have an mx-440....... :( Reply
ZobarStyl - Monday, April 19, 2004 - linkBy this hardware I meant the x800 sorry. Reply
ZobarStyl - Monday, April 19, 2004 - linkThank you, Derek, for politely avoiding going into the current speculation war about the new hardware...frankly no one but ATI knows how this hardware is going to hold up against the 6800, and it's sad that people on both sides have already pronounced winners and losers. A good article; it sheds light on these dark times for nVidia. I'm no fanboy...frankly I'm most swayed by their quality driver support rather than the sheer speed factor. Reply
Modal - Monday, April 19, 2004 - linkThanks for this elucidating article; I find articles of this type (that is "this is what your hardware is doing and why") very interesting. Reply
Regs - Monday, April 19, 2004 - linklol. I just find it funny you wait until now to write this article. But then again, you would likely have a better understanding when we could compare it to the NV40. Reply


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Alexander Disease
National Organization for Rare Disorders, Inc.
It is possible that the main title of the report Alexander Disease is not the name you expected.
General Discussion
Alexander disease is named after the physician who first described the condition in 1949 (WS Alexander). It is an extremely rare, usually progressive and fatal, neurological disorder. Initially it was detected most often during infancy or early childhood, but as better diagnostic tools have become available has been found to occur with similar frequency at all stages of life. Alexander disease has historically been included among the leukodystrophies--diseases of the white matter of the brain. These diseases affect the fatty material (myelin) that forms an insulating wrapping (sheath) around certain nerve fibers (axons). Myelin enables the efficient transmission of nerve impulses and provides the "whitish" appearance of the so-called white matter of the brain. There is a marked deficit in myelin formation in most early onset cases of Alexander disease, and sometimes in later onset cases, particularly in the front (frontal lobes) of the brain's two hemispheres (cerebrum). However, white matter defects are sometimes not observed in later onset cases. Instead, the unifying feature among all Alexander disease cases is the presence of abnormal protein aggregates known as "Rosenthal fibers" throughout certain regions of the brain and spinal cord (central nervous system [CNS]). These aggregates occur in astrocytes, a particular cell type in the CNS that helps maintain a normal CNS environment. Accordingly, it is more appropriate to consider Alexander disease a disease of astrocytes (an astrogliopathy) than a white matter disease (leukodystrophy).
Supporting Organizations
ELA - European Association Against Leukodystrophies
- 2, rue Mi-les-Vignes
- 54521
- Laxou Cedex, 61024
- France
- Tel: 33383309334
- Fax: 33383300068
- Email: email@example.com
- Website: http://www.ela-asso.com
Genetic and Rare Diseases (GARD) Information Center
- PO Box 8126
- Gaithersburg, MD 20898-8126
- Tel: (301)251-4925
- Fax: (301)251-4911
- Tel: (888)205-2311
- Website: http://rarediseases.info.nih.gov/GARD/
March of Dimes
- 1275 Mamaroneck Avenue
- White Plains, NY 10605
- Tel: (914)997-4488
- Fax: (914)997-4763
- Email: firstname.lastname@example.com or email@example.com
- Website: http://www.marchofdimes.org and nacersano.org
NIH/National Institute of Neurological Disorders and Stroke
- P.O. Box 5801
- Bethesda, MD 20824
- Tel: (301)496-5751
- Fax: (301)402-2186
- Tel: (800)352-9424
- Website: http://www.ninds.nih.gov/
United Leukodystrophy Foundation
- 224 N. 2nd St.
- Suite 2
- DeKalb, IL 60115
- Tel: (815)748-3211
- Tel: (800)728-5483
- Email: email@example.com
- Website: http://www.ulf.org/
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders (NORD). For a full-text version of this report, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
Last Updated: 2/20/2014
Copyright 2014 National Organization for Rare Disorders, Inc.
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Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


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HOUSTON - Asians are much more likely to be college-educated than Anglos, according to a new survey from Rice University's Kinder Institute Houston.
The Kinder Institute Houston Area Asian Survey is the first systematic look at the local Asian population based on three surveys conducted over a 16-year period. The findings were released by Stephen Klineberg, Kinder Institute co-director and Rice sociologist.
"Houston has become the single most ethnically diverse large metropolitan region in the United States, and the three Houston Area Asian surveys provide a rare look at this rapidly growing population over time," Klineberg said. "Houston's Asian communities will play increasingly important roles in all aspects of our city's life as the 21st century unfolds."
The surveys were conducted in 1995, 2002 and 2011 along with the annual Kinder Institute Houston Area Survey. They directed questions about demographics, life experiences and societal issues to all of Houston's varied Asian communities. The surveys explored the similarities and differences among the Houston area's four largest Asian communities: Vietnamese, Indian/Pakistani, Chinese/Taiwanese and Filipino.
The surveys found many of Harris County's Asian adults are U.S. born children of immigrant parents. U.S. born Asians are more likely than Asian immigrants to be college-educated. Approximately 58 percent of first-generation Asians are college educated compared to 61 percent of the second generation. In contrast, only 37 percent of Harris County's U.S. born Anglos have college degrees.
Despite levels of education that are much higher on average than those of Anglos, Asians generally have lower household incomes. Thirty-six percent of Anglos report household incomes of more than $75,000,compared with only 28 percent of all Asians.
The 2010 U.S. Census counted 280,341 Asians in Harris County. That is 6.9 percent of a more than four million population. The Vietnamese are the largest Asian community in Harris County, followed by the Indians, Chinese, Filipinos and Koreans.
Since 1994, the Kinder Institute's Houston Area Survey has been expanded to reach large representative samples from Harris County's Anglo, African-American and Hispanic populations.
Copyright 2013 by Click2Houston.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Hear from a NASA scientist and a NASA engineer as they describe their roles in the design and development of one aspect of the James Webb Space Telescope. The video reveals the importance of collaboration in continually moving exploration forward.... (View More) NASA eClips™ Launchpad video segments, designed for grades 9-12, support project-based and problem-based learning experiences in science, mathematics, and career and technical education classrooms. (View Less)
Materials Cost: Free per student
This slide set focuses on the first discovery of an Earth-like planet orbiting a Sun-like star. It is one of a series of short, topical presentations on new developments from NASA astrophysics missions, relevant to introductory astronomy topics.... (View More) These resources are intended to help instructors include the latest discoveries (not yet in their textbooks) into their courses. The slide sets are constructed to be easily included as a lecture supplement including synopsis, references, and graphics. (View Less)
This slide set focuses on the discovery of a massive dust cloud in a supernova remnant. It is one of a series of short, topical presentations on new developments from NASA astrophysics missions, relevant to introductory astronomy topics. These... (View More) resources are intended to help instructors include the latest discoveries (not yet in their textbooks) into their courses. The slide sets are constructed to be easily included as a lecture supplement including synopsis, references, and graphics. (View Less)
This 12-page educational comic book introduces readers to the Global Precipitation Measurement (GPM) mission. Using the Japanese anime art style, the comic book explains the satellite technology and the mission goals and applications. Supplemental... (View More) materials to support the story include an overview of the GPM mission, a description of the satellite and its instruments, examples of the data it collects, descriptions of some of the constellation partners, and a glossary of science terms used in the comic. Links are provided to additional related resources, including a template for learners to create their own comic. The Japanese anime/manga style of art was chosen because the GPM mission is a collaboration between NASA and JAXA, the Japan Aerospace Exploration Agency. (View Less)
Students simulate the process of remote sensing by using common materials to represent Earth's different ground coverings and a light meter to represent satellite instruments. The concept of albedo and its importance in Earth's radiation budget... (View More) are introduced. The lesson uses the 5E instructional model and is part of the book, "Tour of the Electromagnetic Spectrum." (View Less)
Materials Cost: $1 - $5 per group of students
The MISSIONMaker program uses art and the making experience to investigate NASA mission design, engineering and space exploration. Using common materials, students build a rover that incorporates six simple machines. The building instructions... (View More) include design challenges, background information and examples of how NASA spacecraft incorporate and use those same simple machines. The lesson includes step-by-step instructions, templates, explanatory YouTube videos, and additional related resources. (View Less)
Materials Cost: $1 - $5 per group of students
This multi-phased learning package progresses from guided engineering to an open mission-design challenge. Each step is scaffolded and includes easy-to-implement teaching tools, lessons and art activities. Learners, working in collaborative teams,... (View More) build an O-Rex spacecraft model. The building process incorporates inventing, designing and engineering- leading to a deeper understanding of NASA mission work. A leader guide, instructions, templates and a YouTube video are included and accessed through the Related & Supplemental Resources. (View Less)
Materials Cost: 1 cent - $1 per group of students
Create a 3D model of the Chandra spacecraft. Note: requires a 3D printer.
Using a plastic tray filled with sand to represent a planetary surface, learners simulate the effects of wind, water, and impacts. They will compare the surface effects they create with actual images of planetary surfaces- and determine the causes... (View More) of the features in the images. This activity was designed to be used in a library program. (View Less)
Materials Cost: $5 - $10 per group of students
Interested in becoming a citizen scientist? Join Dr. Michelle Thaller as she explains how the general public, using scientific protocols, careful observations and accurate measurements, can help NASA make exciting new discoveries. NASA eClips™ are... (View More) short, relevant educational video segments. These videos inspire and engage students, helping them see real world connections. The Real World series of NASA eClips™ connects classroom mathematics to 21st century careers and innovations and are designed for students to develop an appreciation for mathematics through real-world problem-solving. (View Less)
Materials Cost: Free


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Unchecking the Boxes
This week the Feminism Blog is proud to feature a guest post from Erica Rich, NSVRC Training Specialist, and a former sexual health education professional and coordinator of an LGBTQ youth group.
□ Male □ Female
One of the first things we tend to do upon seeing a person is to place them into a gender category—boy or girl, male or female, man or woman. But what happens when someone comes along who isn't so easy to place—when we can't tell just by looking at them which box to check? This situation tends to make people pretty uncomfortable.
I remember a series of Saturday Night Live skits from back in the 90's about a character named Pat, who was neither clearly masculine nor clearly feminine in appearance or behavior (often termed androgynous). The people who met Pat would go to great lengths to try to figure out whether Pat was a man or a woman while at the same time trying to avoid offending Pat by asking. The characters would stumble over which pronouns to use (he or she), whether to call Pat "Sir" or "Ma'am", and even which haircut or skincare product to offer. The skits featuring Pat were so popular that they were turned into a movie, "It's Pat".
The skits about Pat, humorous as they may have been, highlighted some of the real challenges that people face if they don't fit neatly into the male or female boxes that we have created. We live in a culture in which everything from clothes to toys to colors is gendered and there isn't much room for in-between. Have you ever tried to buy a baby shower gift for a couple who has decided not to find out the baby's sex until birth? Even talking about people who are gender non-conforming (those who do not adhere to society's rules about dress and activities for people that are based on their sex) is difficult as we don't have the language in place. I'll admit, even I had a difficult time writing about Pat without saying "he" or "she", or resorting to the grammatically incorrect term "they".
While the people in the SNL skits generally tried to be sensitive towards Pat by not making assumptions or using inappropriate terms, the reality for gender non-conforming people is starkly different. In a recent school climate survey, 29% of LGBT students who said they conformed to traditional gender roles reported being verbally harassed by peers. When the question was asked of LGBT students who identified as gender non-conforming, that number nearly doubled, at 58.7%. Gender non-conforming LGBT youth were also more than twice as likely to report being physically assaulted (8.9%) than those whose gender identities more closely matched their biological sex (4.0%).
The unwritten rules about what is acceptable for males and what is acceptable for females—along with the idea that those are the only two possibilities—are so deeply rooted in our culture that those who attempt to bend or break those rules are often faced with harassment and violence. A binary gender system that promotes violence and harassment against gender non-conforming people is a system that promotes sexual violence. Instead, let's work toward a system that values all people, thinks outside of the two boxes, and respects each person's right to individual expression.


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Cheap Super Computer
There is a device that can add, subtract, multiply, divide, do any mathematical problem, write in any language, find out any universal problem, tell you any secret, and solve all human questions. It was invented quite a long time ago, is small enough to fit in your pocket, has a deleting device on it as standard equipment and only costs a few cents. How can a store sell such a magnificent device for a few cents without losing money? What is this great product and why hasn't the world used it for its maximum power?
AnswerIt's a pencil.
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Classic Films of a Bygone Era 8Trivia brain teasers have some element of trivia in them, but they are not just pure trivia questions.
Below are four (4) anagrams of film actors from a classic film from the Silver Screen. Your job is twofold: firstly, try and name these people and secondly, ascertain the classic movie they all featured in. I have included the number of letters of each actor's name in brackets.
An actor! He'll gush (7, 8)
Wide, cracked rich (6, 9)
The hot, slim calm (6, 8)
Humane or area (7, 5)
HintMemorable quotes:
"Ohh, you asked me why I saved you. I tried to carry you off, and the next day, you gave me water, and a little pity."
"How about you, doctor? Doesn't she set your pulse running?
"I'm a widower four times over, sire, but I could begin all over again gladly."
[to one of the stone gargoyles] "Why was I not made of stone - like thee?"
AnswerCharles Laughton
Cedric Hardwicke
Thomas Mitchell
Maureen O'Hara
The film: The Hunchback of Notre Dame (1939)
The cast:
Charles Laughton - Quasimodo
Cedric Hardwicke - Frollo
Thomas Mitchell - Clopin
Maureen O'Hara - Esmeralda
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Uncle Jessie's fishing lure
Established in 1999, this lure has become a go-to favorite to catch white perch. Even better, although Uncle Jessie's lure was designed specifically for white perch, it will actually catch a variety of fish. It has received North Carolina Citation awards for white perch, bream and brown trout. The lure has plenty of weight and flash and can be thrown on spinning or bait casting gear. You can purchase them through the website or you can call longtime angler Chris Morris of Morris Tackle, an Albemarle EMC member who lives in Tyner. $4 each.
Morris Tackle
(252) 221-8448


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This is odd.
Esteemed military strategist and House Speaker Nancy Pelosi announced this evening that the Iraq campaign in the War on Terror "is a failure," adding that President Bush's troop surge "has not produced the desired effect."
"The purpose of the surge was to create a secure time for the government of Iraq to make the political change to bring reconciliation to Iraq," Pelosi told anchor Wolf Blitzer on CNN's Late Edition. "They have not done that."
Who hasn't, precisely? "The troops have succeeded!" crowed Pelosi. "G-d bless them."
Well, that's a relief. The troops are off the hook; Pelosi made it plain a minute or so later that it was actually President Bush who had failed to do their job.
Meanwhile, the U.S. military today released exerpts from captured letters, including one written by Abu-Tariq, emir of al-Qaeda's al-Layin and al-Mashahdah sectors in Anbar province, a focal point of the recent troop surge.
Of the loss of Anbar province, Abu-Tariq wrote: "This created weakness and psychological defeat. This also created panic, fear and the unwillingness to fight. The morale of the fighters went down.... There was a total collapse in the security structure of the organisation."
The emir complained that the supply of foreign fighters had dwindled and that they found it increasingly hard to operate inside Iraq because they could not blend in. Foreign suicide bombers, determined to kill "not less than 20 or 30 infidels," grew disillusioned because they were kept hanging about and only given small operations. Some gave up and went home.
One can only guess that communication difficulties must have prevented Abu-Tariq from receiving Nancy Pelosi's memo regarding his success in containing the U.S. troop surge. Just imagine the frustration in the leadership caves along the Pakistani border as Osama bin Laden and his lieutenants come to grips with the realities of managing high-echelon intelligence assets in far-away Washington!
Of course, if the Democrats take the White House in November, OBL and his cronies will really be in for a shock. It should take about five minutes for the Clibama administration to wrest open the jaws of defeat, declare victory in Iraq, and pull chocks for home.
Unless al-Qaeda doesn't get that memo, either...


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Poach Pods
add vinegar to the pot? watch the simmering level? spoon the whites together? and they might not even poach correctly? too much effort for a little Eggs Benedict. now just crack an egg into a poach pod, drop it into a pot of simmering water, and they come out perfectly, roundly, poached


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Cake serves 15. Cookies each serve 1.
Prepare cookie recipe. Spray pan with vegetable pan spray. Press cookie dough into pan cavities; press cookie sticks into dough. Bake and cool cookies following recipe directions.
Place cooled cookies on cooling grid over a parchment-lined cookie sheet. Cover with thinned leaf green tinted royal icing; let set until firm. Remove white Sugar Sheet from plastic backing. Using 2nd smallest round cutter as a guide and black FoodWriter marker, trace 4 circles on the back of the sheet. Cut out circles and attach to iced cookie pops with piping gel. Let dry.
Bake your favorite 2-layer cake recipe or mix in 9 in. round pan. Cool cake in pan on cooling grid 10 minutes. Remove from pan and cool completely. Wrap cake circle with Fanci-Foil wrap. Arrange cooled cake layers on prepared cake board.
Spatula ice cake with buttercream icing. Cut 5/8 in. wide strips from bright green Sugar Sheet.. Attach as bottom border to cake, using piping gel if needed.
Using Rotary Cutter or knife, cut 1/4 in. x 5 in. long bright yellow Sugar Sheets! strips; position end of quilling tool over end of strip. Twist quilling tool to wind strip around. Continue twisting to create a spiral, guiding end of strip around tool with your other hand. Secure end with piping gel; set aside.
For flower petals, use Rotary Cutter or knife to cut strips of desired colors of Sugar Sheets 1/4 in. wide x 3-1/2 in. long, 2-1/2 in long and 1-1/2 in. long (10 each required for full flower; 7 each for half flowers). Start with shortest strip. Brush one end with damp brush, bend strip over to form a loop and pinch ends together to secure. Repeat for next largest strip, forming a loop around first loop. Brush end with damp brush and pinch ends together to secure. Repeat with next largest strip. Continue building groups of loops to form flower petals.
Arrange flower petals as full flowers and half flowers on cookies and cake, securing with piping gel. Cut 1/4 in. wide x 3 to 5 in. long bright green Sugar Sheet strips. Twist into swirls and "s" shapes and attach to sides of cake with piping gel. Insert Cookie Pops into cake top.


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About the Book
Finally, we have an outdoor design book that is both inspirational and practical. The various design concepts are demonstrated using actual projects designed and built by outdoor designer Lucas Congdon of Lucas Lagoons, Inc. in Sarasota, Florida. All water features and landscapes are built using only natural materials and each job is unique. You will find ideas on every page as well as instructions for incorporating Lucas's concepts into your own outdoor design.
About the Creator
I am an award winning exterior designer and the President of Lucas Lagoons Inc. I began my career working in my parent's landscaping business in Vermont almost 15 years ago. It was there I developed my natural talent for working with stone. The Vermont mountain influence can be seen in many of my exterior designs. I moved to Sarasota nine years ago, and seven years ago, I started Lucas Lagoons, Inc. with Barbara Luehring to design and build luxury outdoor living areas and lagoons in Sarasota, Florida and surrounding areas.
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WINTER PARK, Fla. - Saint Leo junior guard Marcus Ruh has been recognized as the Sunshine State Conference Men's Basketball Player of the Week it was announced by league officials on Monday afternoon.
Ruh helped the Lions win their fifth straight SSC game in a row, averaging 22.5 points, 7.5 rebounds, 4.5 assists, 2.0 steals, and 1.0 block per game. The Green Bay, Wisc. native opened the week by tallying 19 points, nine rebounds, seven assists, four steals, and two blocks in a 75-72 victory at Florida Southern. Seventeen of his 19 points came in the second half. Ruh then collected 26 points, six rebounds, and two assists in a 61-49 win over Nova Southeastern.
In two contests, he shot 60 percent (18-for-30) from the field and 88 percent (7-for-8) at the free throw line. The Lions' win streak has guaranteed their first winning season since 1997-98.
Ruh is one of 24 Saint Leo student-athletes, and three this week, to be named SSC Player of the Week in 2011-12.
The Lions will take their win-streak and memorable regular season into its final week where they will host cross-bay rival Eckerd College on Wednesday night. The matchup between the conference's no. 2 and no. 3 teams will tip-off at 7:30 p.m. in the Bowman Center. For the latest news, information, and updates on Lions' Basketball and all other Saint Leo Athletics, visit SaintLeoLions.com.
Click here for the entire Sunshine State Conference Weekly Release for the period ending February 19.


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Our art gallery includes many colorful abstract paintings for sale, with new pieces added daily. Expressionist, colorist, mixed media, futurist, surrealist, and other styles
Found 3091 matching paintings
link to us - subscribe - about - contact us - press room - login
The Daily Painters Art Gallery - www.dailypainters.com
© 2017 Daily Painters Gallery. All artwork is copyrighted by the individual artists.
Images may not be reproduced without the permission of the artist.


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ABOUT 10,000 homes in Oxfordshire were under the threat of flooding last night as a surge swept through the county's waterways.
The total included almost 5,000 homes in Oxford itself that were placed on red alert by the Environment Agency as residents were urged to take action.
Several rivers were also peaking last night as the Environment Agency worked to try to minimise the number of properties at risk.
Environment Agency statistics showed that the River Cherwell at Kings Mill in Marston, Oxford, was a centimetre higher than during the July 2007 floods.
Sand and bags were made available at PC World in Botley Road, and Bullstake Close for all worried Oxford residents, as more than 4,500 sandbags were delivered to countywide properties.
The county council said rest centres were being set up in the event of evacuations.
Defence barriers were deployed near Hinksey Lane, South Oxford and at Osney Island in the hope of protecting hundreds of properties from damage.
Nick Gee, 45, a pest controller from Binsey, said: "I heard the warnings and went charging out to get some sandbags. Binsey is a little community village of about 20 houses and I have a Land Rover so I am doing the runs for the village. The water surrounds us on both sides."
Yesterday officials said 14 homes or businesses had been recorded as being flooded in Oxfordshire since Thursday.
Rainfall overnight Sunday and into yesterday morning resulted in nine flood warnings – where immediate action must be taken – placed on rivers in Oxfordshire, with five coming in quick succession shortly after 8am.
Hundreds of residents living near the River Cherwell from Lower Heyford down to Cherwell Bridge, the Thame, and Thames and tributaries at Kennington, New Botley, New and North Hinksey and Grandpont, Binsey, Osney and Osney Island, Newbridge and Kings Lock above Oxford were all placed on the highest warning issued by the Environment Agency.
Environment Agency spokeswoman Jessica Davison said residents must prepare for the worst.
"River levels are still increasing and we cannot rule out any property flooding in the next few days," she said.
"We are working with our partners in and around Oxford where there are very high numbers of properties at risk to warn the public and erect the demountable defences."
High-risk flooding areas across Oxfordshire were targeted as a combined effort between emergency services, district councils, the county council and the Highways Agency kicked into gear.
The slip road into Kennington was closed by Vale of White Horse District Council to prevent drivers entering the village from the Oxford end and to offer protection to residents living near the flood plain.
Oxfordshire County Council Fire and Rescue Service's operations and resilience manager Nigel Wilson, urged residents of properties in potential flood areas to stay alert.
"Failure to heed these warnings puts drivers and passengers at the risk of being trapped in their vehicle and any disturbance of the flood water from a passing vehicle increases the damage to surrounding properties," he said.
Among those picking up sandbags at PC World in Botley Road was Andy Egan, 49, of Earl Street. He said: "The first thing my four-year-old son Kai wanted to save and move upstairs was his Lego. The water may well come across Botley Road to our road as it did in 2007."


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- Silver electroplated
- Post hoop earrings with clear rhinestones
- Hypoallergenic surgical steel posts
- Rhinestone pendant
- Textured link chain
- Clasp closure
- 17"-20" Adjustable chain
- Protected with Montana Armor
Complete any outfit with this dazzling rhinestone earring and necklace set by Montana Silversmiths. This set features post hoop earrings that are set on hypoallergenic surgical steel posts are are detailed with clear rhinestones. That matching silver pendant is also detailed with magnificent clear rhinestones that will look great for just about any occasion. The pendant hangs on a textured linked chain silver necklace that is adjustable so you can wear this necklace at the perfect length. Wear these earrings and necklace together or separately for a great look any time! To maintain you jewelry's brilliance wipe it occasionally with a damp cloth. DO NOT use chemical or abrasive cleaners, as that will remove the protective coating on the jewelry.
Style(s): JS1132, JS1133
Count on Montana Silversmiths to provide an incredible array of distinctive buckles and jewelry inspired by the west featuring classic authentic designs with unique modern flair. Fit your life and style with Montana Silversmiths extraordinary quality and classic styling, make them you own "The West Your Way."
Montana Silversmiths distinctive western home decor "Montana Lifestyles" makes the perfect compliment to any western interior by richly capturing the spirit of the West in authentic sculptures, tabletop dinnerware, picture frames and more. Montana Lifestyles set the stage for family and friends serving as conversation pieces and as a backdrop for memories that will be treasured for a lifetime.
Established in Columbus, Montana in 1973, Montana Silversmiths® is a pioneer manufacturer and distributor in the western industry. Their skilled craftsmen are the finest in the western industry, perfecting a combination of traditional western designs and crisply executed engraving styles which include buckles, jewelry, and lifestyle products for the western enthusiasts. The company has a solid stable of trusted brands including Montana Lifestyles™, Cowboy Kickers™ Footwear, Attitude Buckles, and of course, the world renowned Montana Silversmiths® Buckles and Jewelry.


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The Valley Art Center's 31st Annual Art by the Falls juried art festival will take place June 7 and 8 at Riverside Park in Chagrin Falls.
More than 120 artists from around the country will display and sell their work 10 a.m. to 7 p.m. June 7 and 11 a.m. to 5 p.m. June 8. From fine jewelry, fiber and wearable art, exquisite paintings and photography to striking sculpture, pottery, art glass, hand crafted wood pieces, metal art and art for your garden, the show offers something for almost everyone's taste and budget.
A make and take children's booth will keep the little ones busy with a creative project for a donation while parents have time to shop and meet with friends.
In addition to exceptional artwork and several renowned artists demonstrating their craft, such as woodcarver David F. Shankland, the show includes an artful selection of live music and performances in the park during the show hours. Performances range from folk and rock to Native American flutes, and even belly dance and modern dance troupes will perform. Of course there is a delicious selection of food to choose from with seven vendors participating.
As always, admission is free. It doesn't get any better than that, according to VAC Executive Director, Mary Ann Breisch. She said the event draws artists to the region from throughout the nation and Canada and hundreds of patrons visit the show year after year.
"There's always something new to surprise and delight our visitors," Breisch explained. "There will be some exciting exhibitors who will be new to this event along with veterans who consistently manage to bring fresh artistic ideas to the show. Our artists look forward to the event as much as their patrons."
In addition, this year Valley Art Center and Chagrin Arts will present the first ever Chagrin Falls Music Crawl June 7 from 6 to 9 p.m. after Art by the Falls.
Volunteers are needed for the event. Contact valleyartcenter.org or call 440-247-7507.


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Results 1 to 9 of 9
- Join Date
- Dec 2011
- Posts
- 45
About the Retro City Rampage WIT...
Link of the review: http://www.rockpapershotgun.com/2012...ampage-review/
Well, I think it's the first time that I've seen blatant advertising on RPS.
It's just logical to think that RPS have been promoting Hotline Miami to hell, and for some reason they need to bash on potential customers that will buy Hotline Miami instead of RCR.
In the Retro City Rampage there's no mention of the 10 years that took Brian Provinciano to finish that game. No mention of the technical achievement to fit SO MUCH CONTENT on just a couple megabytes. No mention of the BIT.TRIP and Meat Boy mini games included, that are awesome per se, and worth at least a buck each (yes, the minigames). Besides, the PC version is awesome considering that the game is also on Vita and other consoles: you can get plenty of filters (my, when I turned on that CGA filter...), windowed mode, borderless, etc.
Why Alec can't see that it's just a game without a story, a parody of itself? It feels like a Wario Ware Inc., but done much better. Is a casual game? Yeah, you can pick it up, finish a couple of missions then turn it off in 10 minutes. Or, you can try the challenges and tear your hair out, as with getting that perfect score on BIT.TRIP.
Whilst, as far as I can see, Hotline Miame IS pretty good, but it's just another tactical shooter, done in 2D. And that's all the gameplay it has. Enter a mission, shoot guys, get out. And that's it.
I might still get HM though, but all this advertising made me real sick.
- Join Date
- Jun 2011
- Posts
- 291
I'm not really sure what you're trying to say here. That it's just advertising for Hotline Miami?
- Join Date
- Jun 2011
- Location
- Lagoon West, Vermilion Sands
- Posts
- 5,046
As much I agree with the point that the amount of work that went into that title and that it was the creation of a single person should be aknowledged, I don't think that it should be used as an excuse. As a consumer, I'm not going to enjoy a title more just because I know how much trouble it took its developer to actually make this thing. You can admire his work and you can even decide to buy the title simply because you want to reward/support this paticular developer (which was the reason why I bought Retro City Rampage), but in the end it comes down to whether or not I actually enjoy the game. Since I like hamfisted humour and absurd stories, I enjoy Retro City Rampage, but I can see why people don't like it and it does not surprise me that there are a lot of people who don't really know what to make of this game.
I also can't follow your argument when it comes to the apparently 'blatant advertising' of Hotline Miami. How would RPS benefit from that? I don't see any connection between the developer and/or publisher of Hotline Miami and RPS.
Of course there could be some kind of evil conspiracy behind this, but seriously, if a Gaming site would decide to be corrupt it would most certainly try to receive bribes from more wealthy companies and not from some kind of niche-developer.
Do you know what I think? I think you're just upset that a reviewer whose opinions you usally trust, does not like the game in the way you like it. Maybe it's because you're emotionally more attached to this product then Mr. Meer was, but be it as it may, it does not matter. It's not the job of a reviewer to tell you what to like and dislike. It's his job to state his opinion about a cetain product and hopefully find some reasons as to why he likes/dislikes certain things. It's then up to the consumer to decide how much the reviewers points actually matter to him.
The world doesn't care how hard you worked. Only the result matters. If you're shit at something and you work really hard, you're probably still going to produce shit. Hard work is usually necessary but never sufficient in itself to creating something great.
You're aware that you can comment directly on the articles, right? Not sure why this needed to have a topic created for it.
oh dear, here comes the paranoid, insulted internet again.- Tom De Roeck.
verse publications & The Shopkeeper, an interactive short.
"Quantacat's name is still recognised even if he watches on with detached eyes like Peter Molyneux over a cube in 3D space, staring at it with tears in his eyes, softly whispering... Someday they'll get it." - The Conclave
I'm afraid the amount of work that goes into something can't be a factor when it comes to describing subjective enjoyment of it, which is what our "Wot I Think" reviews are concerned with.
As for it being attacked as a consequence of us favouring Hotline Miami on an "advertising" basis, well, that's complete nonsense, without any basis. For all I know we could end up hammering HM too, we've not reviewed it yet.
I find it remarkable that anyone still believes that our reviews are swayed by advertising money when we have a *consistent* record of attacking games that we're advertising. Look at my Of Orcs & Men review for an example of that happening last week.


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You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
"Loved that I could personalize the card with my colors and wording. Also, getting to see an example of my product before finalizing the order was very reassuring!"
"Lovely invitations, delivered to us quickly and in great condition. Excellent experience working with the graphic designer."
"Personalization was EASY fill in the blanks! I used custom colors and even making changes was an easy process. I was looking for nice and simple and i was very happy with what i got. if you are into fancier options they can dress it up shine it up and all that. you get to customize and pick everything. my guests thought they were very pretty."
"Loved these invitations. The quality of the paper was great. They turned out just as I had hoped for my daughter's wedding invitations."
"Wedding Paper Divas was recommended to us by friends who ordered their wedding invitations here too. We found the website and the design process very simple to use. The price was fantastic and the delivery service top notch! On top of that we could not be happier that we chose to order our wedding invitations here!"


text: Year in Review Amanda Morris | News Editor Anna Morris | Assistant News Editor An overview of top news stories from the past academic year. More > "Chappy K," Harley Davidsons and Faithfulness: A Q-and-A with Chaplain Stephen Kellough Amanda Morris | News Editor On the morning of Monday, April 28, the usual chapel bells calling students into a time of worship rang longer than usual — 25 times, to be exact. As the bells rang, all in attendance stood to give Wheaton College chaplain, Stephen Kellough, a standing ovation for the 25 years that he has served as chaplain. More > From the Chaplain's Office Sarah Kenny | Features Editor The students, staff and faculty that traffic through the Chaplain's office are greeted by the smiling and accommodating Marilyn Brenner, who has overseen the front desk of the office since her arrival in 1996. More > General Education Revision Process Continues with General Educaton Summit Amanda Morris | News Editor Several months after faculty members voted down a proposal for a new general education curriculum, the Wheaton College administration has created a General Education Summit composed of faculty, student, administrative and staff representatives to move general education reform into its next phase. More > Wheaton Softball Closes Out Season Sam Smith | Staff Writer The Wheaton softball team ended its season with a 3-3 record in the final six games. More > Mid-Week Victories Set Up Fight-or-Flight Weekend Judah Newby | Assistant Sports Editor The Wheaton Thunder baseball team enters the final weekend of the regular season on the outside looking in to the postseason party. However, not all hope is lost. More > Wheaton Track Teams Nab Fourth at Benedictine James Connelly | Staff Writer Both the men's and women's Thunder track teams finished fourth out of 17 and 14 teams, respectively, at the Benedictine Twilight Invitational on Friday, April 25. More >


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Ansel Adams: A Life's Work
23 May, 2009 - 4 Oct, 2009
The exhibition includes over 80 photographs by the 20th Century master, and celebrates Adams as an artist and conservationist.
A Life's Work features an overview of Adam's work from his early years in Sierra Nevada and Yosemite Valley, to his work in the Japanese Internment Camp at Manzanar, as well as his well-known masterpieces.
As one of the most celebrated and renowned artists of the 20th century, Ansel Adams expanded the practice and appreciation of photography as no other photographer has before, or since. As an environmentalist and a vital member of the Sierra Club, his efforts as a pioneer and crusader for the preservation and protection of America's natural beauty has been duly celebrated and recognized. His legacy as an environmental activist continues to mount importance and relevance today, as his photographs and images perpetuate the vital message of preservation and conservation for younger generations.


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Garment worker Rikta, 27, who worked on the third floor of Rana Plaza, poses for a portrait at Enam Medical College, in Savar, near Dhaka, Bangladesh. Rikta had her right arm amputated inside the rubble when she was rescued nearly 72 hours after the building collapsed.
© The Financial Times Ltd 2016 FT and 'Financial Times' are trademarks of The Financial Times Ltd.


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Cool Trucker Girl /Mudflap girl Soaps for Men!
Finally there are some fun and good smelling soaps out there for the men in your life. These organic, handmade soaps come in wonderful and hilarious shape of the famous Mudflap girls (or trucker girls)! Sophisticated colors like two tone brown and orange or sparkly navy blue make them the perfect gift for the holidays! Papaya Mango, gingerbread and black lime are just a few of the scents. Check them out!


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Here's the weekends activities.
I broke out the Heavy and filled her up.
5 ea 10lb hams using Bob's injection glaze
1 Turkey Breast marinated in a butter herb
3 Racks of babybacks
2 ea 10 lb picnic shoulders
2 ea 5 lb brisket flats
5 lb chicken breasts in an asian theme
20 or so Sweet Italian sausages
and here's two from Memorial day.
Next up we'll see how many burgers and dogs we can fit on her on Friday!


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The FT reports this morning that Michel Barnier, Europe's top financial regulator, has shelved plans to rein in the credit rating agencies. Barnier, who is internal market commissioner, had to bow to objections elsewhere in the EU. We report that Barnier still unveiled proposals to transform the business model of the big agencies but has ordered some last-minute "technical work" that amounts to a ceasefire.
Both Barnier and the rating agencies were discussed in the House of Lords last night, where former City minister Lord Myners was on scathing form. First the Labour peer (a former chairman of Marks & Spencer) criticised the "flawed thinking" from the European Commission on the issue. He then continued:
I worry very much about Mr Barnier. I met Mr Barnier when he was a Minister. He came to see us at the Treasury. He came down the corridor and I was watching him. I am a great fan of art and I was rather impressed that he stopped to look at every painting. I thought this is a man with whom I share a common interest-until I realised he was actually looking at his reflection in the glass on every painting, and adjusting his hair or his toupee. This to me is a man whom we should treat with a very long spoon. I hope the Minister will take due care in working with Mr Barnier because we have been forewarned that this man intends to seek even more powers than those he announced today. He said he wants to return to the issue of censoring


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T-Mobile to slash the prices of its "Even More" unlimited plans even more
The Even More Plus, which is hard to come by these days, unless you beg for it in the stores, will go down to $69.99 from the current $99.99, while the Even More contract customers will get $20 shaved off their monthly bill, down to $79.99.
It is not entirely clear if existing customers will be automatically included, they have to call, or what's the deal here. We'll know more in just a week's time, when the Samsung Galaxy S 4G gets delivered to the shelves with its 21Mbps-capable HSPA+ radio.
source: T-MoNews
10 Comments
2. Ash (unregistered)
You got it wrong, EM+ is the cheaper one. Not EM
3. snowgator (Posts: 3604; Member since: 19 Jan 2011)
Only one of the four major carriers not giving me service in rural IL. Stupid, stupid T-Mobile. But, I am happy for those who have option. (Stupid T-Mobile.)
4. oddmanout (Posts: 443; Member since: 22 May 2009)
I'm paying 79.99 for 500 talk, unlimited messaging, and unlimited web. If their gonna match the price of their 500 talk plan with the unlimited talk plan, they should lower the 500 talk plan as well.
10. strawberrychick2869 (Posts: 1; Member since: 26 Feb 2011)
I Have the same plan. Even More Plus 500 plan 500 mintues unlimited text and web and i pay 74.56, does this mean they are going to cut the price in half? or no?
i was thinking about switching to the Pre-Paid $50 a month bc its unlimited talk and text,which is cheaper.i wonder why most peoplewontuse that plan instead of this one. its much cheaper
5. Antbed (unregistered)
Dont think they will lower n e other plans. Frm wat my mngr told me...its just a promotional plan. Right now they hve the 1500 mins unlimited txt and web for 79.99 so I guess its replacing tht plan.
6. joey18 (Posts: 597; Member since: 20 Jul 2010)
tmo has much better plans verizon or att. are similar plans ....4g plans are going to b espenced 120 at month is to much ....
7. Landmarkcm (Posts: 506; Member since: 11 Aug 2009)
This will be a good plan for Tmo too bad there coverage still sucks. I just switched to Att from Sprint now that they offer unlimited anymobile which is awesome. So on there 450 min plan which after my discount is 33$ and then unlimited mobile calling and messaging add on for 20. Plus data 200 for fifteen (which is all I need 90 percent using wifi) Im good.. Gotta love this industry though it's ever changing! Verizon on the other hand is just the biggest RIP ever! I dont care how good there "network" is LOL..
8. Ange S (unregistered)
@oddmanout you're right-in all fairness, yours should also be lowered! Got to love this industry...you can never really plan ahead for anything-ever changing and for 1ce it's a positive change! For me Straight Talk works just great and costs me $25 less than Tmo's improved pricing-also unlimited everything and on AT&T network (or Verizon if you're zoned right).
9. ssjassassin (Posts: 108; Member since: 31 Aug 2009)
Phone arena really? EM+ Unlimited TTW is 79.99 EM Unlimited TTW is 99.99. If they drop the price it will be a promotional plan. T-Mobile loves promotional plans and so do the customers. They set a focus on a type of customer and offer the right promo to set them up. The 4G do more plans focused primarily on family's of two or more smartphones. A family of four could have all smartphones with 3000 minutes unlimited talk and text for 200 plus tax. The closest you could do at verizion is 700 for 250 plus tax unless you got hooked in for the free add a line credit that goes away after your contract then it is more like 230.


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By guest blogger Geeta Sachdeva
Next weekend is Mother's day. How about taking the opportunity to get some wedding stress off your mind? Plan a wonderful day with your Mom. Remember that these past few months have probably been a whirlwind for her as well. So why not involve her in the planning process, seek her advice and make her feel that you value her opinion? Make the most of this time, and tell her the wedding of your dreams will be incomplete without her support.
A great idea would be to give her a handmade Mother's day gift that shows how much she means to you. A personalized photo album would be great for showcasing your childhood memories.
Another cool idea would be to have two cards in contrasting colors placed on adjacent pages, using one as a frame for pictures or memorabilia and the other for writing comments! (I got the Wild Grass Wedding Reception Cards in chocolate and soft pink from Wedding Paper Divas.)
Here is a page from my scrapbook. I hope it inspires you!
Image courtesy: Matteus Pan


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Thanks to DV8Mad for the idea
Here are other Lowballs that are going on:
The originator of the Lowball DV8Mad's Lowball: http://www.cheapassg...ad.php?t=270054
CD's Lowball: http://www.cheapassg...ad.php?t=168998
Fatboy's Lowball (It's almost monthly): http://www.cheapassg...ad.php?t=204259
Ash Burton's: Lowball: http://www.cheapassg...ad.php?t=292283
Starmask2k3 Lowball: http://www.cheapassg...ad.php?t=271317
Gotian's Lowball: http://www.cheapassg...ad.php?t=270281
Goguenator's Lowball: http://www.cheapassg...ad.php?t=287084
Lowball Rules
1) Simply type in your max bid for these items in the forum replies. No PMs. No Emails. Just reply in the forum reply section. This is to keep bids public and to keep my PM box from overflowing as it has in the past.
2) I will update the page to reflect your bids and at the end of the period I will declare the winners and tell you where to send the money.
3) $1 minimum for any items. You can win them for as little as you bid. So if you bid $1.00 and win it, it's yours for a $1.00 (plus shipping). If someone bids $5 and you outbid them for $10, you win the item for your max bid and pay whatever you bid plus shipping ($3-$5 USD or so).
4) Please note that you will be expected to pay the amount you bid plus appropriate shipping if you have the highest offer at the end. Negative feedback may be left for those who choose not to follow through with payment.
5) Shipping for Box Sets, Special Editions and heavier items will be slightly higher. I will try to list approximate shipping next to these items.
6) International buyers are welcome, but please note your shipping is likely to be more expensive.Simple as that ^_^ If you have any questions just ask.
Shipping Estimates (For Games/Single-Disc DVDs):
US Residents: $3.00 per game (includes shipping/packing materials)
If buying more than one item please add $1 per additional item.
* If you end up with a bunch of light things, I will refund some of the shipping to you afterward if it's more than a few bucks difference.
Shipping are going to be sent by USPS First Class, Priority, or Media Mail (depending on the items won).
Guides shipping starts at 3.00 flat. The heavy guides are $4.
My Paypal address is firstname.lastname@example.com. PM Before or after sending payment.
FlingSmash game only (sealed) $5- Mixer236
Games and DVDs
Shadow of The Colossus (GH, sealed) $6- yellowdog
DDRMax: Dance Dance Revolution $1-dustdingo
DDRMax2: Dance Dance Revolution
Dance Dance Revolution SuperNova $1-dustdingo
Dance Dance Revolution Extreme $1- dustdingo
Dance Dance Revolution Extreme 2
Balder's Gate: Dark Alliance II (No case or manual) $5- thejam
:GBC: Rayman (Game only)
Prince of Persia (2008 version, sealed/cardboard) $1 thejam
Space Chimps (sealed)
Lost Season 5 (sealed) $3-yellowdog
SWAT (sealed)
The Incredibles $1- Vulgarism
Monsters Inc. $1- Vulgarism
God of War 2 LE guide (heavy guide) $3-battousai11
God of War 3 guide $1- kobberbean
God of War Ghost of Sparta guide $1-battousai11
Demon Summoner guide $2- kobberbean
Call of Duty: Modern Warfare 2 guide (Heavy guide)
Lego Indiana Jones 2 guide
Super Mario Galaxy 2 LE Guide $2- kobberbean
Bioshock 2 guide $1- thejam
Medal of Honor LE Guide
Bully SE guide (Heavy Guide) $1- thejam
Blue Dragon guide $1- thejam
Alan Wake guide
Iron Man 2 guide
Super Street Fighter 4 guide $2- DudeImGodly
Singularity guide
Zelda: Spirit Tracks LE guide (Heavy Guide) $2- DudeImGodly
Books, Comics, and Gaming Stuff
White Wii Remote without Motion Plus $3- dustdingo
Eternal Sonata Faceplate $1- DudeImGodly
Deathsmiles Faceplate $4- DudeImGodly
Growlanser Art Book & Media Disc (came with Limited edition) $1-yellowdog
PiranhaPad PC Controller
Ghost Rider: The Visual Guide
X-Men Deadly Genesis #1
Wolverine #66 (old man Logan Part 1)
Young Avengers #3
Deadpool #1 (2009)- $1- kobberbean
Wolverine #50 (1992)
End of the LowballComic Book Sale
$1 each or 7 for $5
Marvel Team-Up #1(1997)
Marvel Team-Up (1997) #2
X-Man #3 (AOA)
Cable #87 (dream's end storyline)
Divine Right # 11
Angel (buffy) (1999) #1
Classic X-men #1
X-men #180
Green Goblin #1
Sensational Spider-Man #0
X-Nation 2099# 1
New Warriors #5 (2000)
Nova #1 (1998)
Nova #2 (1998)
Nova #3 (1998)
Starjammers #1 (2004)
Peter Parker: Spider-Man #30 (2001)
Buffy The Vampire Slayer #14 (First Series)
Amazing Spider-Man #507
Amazing Spider-Man #506
Amazing Spider-Man #505
Amazing Spider-Man #519
Amazing Spider-Man #520
Amazing Spider-Man #521
Thunderbolts #36
Thunderbolts #38
New Excalibur #1
X-Force (Not the Cool New One but 2004) #1
WildCats: Divine Intervention #1 (Divine Right Tie-In)
Ultimate Elektra #1
Thundercats: Dogs of War #2
Soul Saga #1
Uncanny X-Men #466
Uncanny X-Men #467
Wolverine #38
Captain America #25 (Vol. 2)
Captain America #26 (Vol.2)
Captain America #27 (Vol.2)
X-Men: The End #1 Book One
X-Men: The End #1 Book Two
$2 each or 7 for $10
MK: Spider-Man #1
MK: Spider-Man #13
Ultimate Fantastic Four #5
Ultimate Fantastic Four #3
Ultimate Fantastic Four #6
X-men Deadly Genesis #1
New X-Men #1
Ultimate X-Men #61
Ultimate Nightmare #1
1602 #1
New X-Men #20
Ultimate Spider-Man #47
Ultimate Spider-Man #49
Avengers: The Initiative #2
Young Avengers #3
Civil War: The Return #1
Wolverine #66 Old Man Logan part 1
Wolverine #50 Volume 1 (die Cut)
Amazing Spider-Man #544 (Beginning of ONE MORE DAY)
X-Men: Endangered Species #1
Uncanny X-Men #444
Uncanny X-Men #445
$3 each or 4 for $10
Cyblade/Shi #1 (first Witchblade appearance)
Deadpool #1 (2009)
Uncanny X-men #269
Ultimates 3 #1
Spawn #9
Avengers #500 (Avengers Disassembled)
$5 each
Kingdom Come #2
Sailor Moon #1
Runaways Vol. 4- True Believers (Digest Size)
Runaways Vol. 5- Escape To New York (Digest Size)
Bundles Prices listed
Captain Marvel (2003 series) #1-13 (Crazy Captain issues) $12 or Best Offer
Ultimates 2- #1-8 $12
Out There #1-14 $13
Super Pat Lee Bundle (Darkminds 1/2,3, 5-8; Warlands #1-3 and Neon Cyber #1-4) $7
Bishop: The last X-Man #1-6 $5
Deadpool (1997 series) #1-2 $10
Mystique #1,3-6- $7
Cable & Deadpool #1-4 $15
Superman/Batman #1-3 $12
Maverick 2-3, 7-9- $6
Deathlok #1-8 $10
Ultimate Spider-Man #3 BO
Ultimate Spider-man #7 BO
Regular Tradelist
Here Is The List of comics that must leave my home:
Edited by WeaponX2099, 29 May 2011 - 06:33 AM.
New stuff


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This year my husband and I bought a Viking stainless steel grill with porcelain grill grates. The grill is great, but it is a bear to clean. Does anyone have any suggestions on how to clean the stainless steel portion so that it does not take an entire day to clean. Also, I have in the past cleaned the porcelain grill grates with Oven cleaner, however, it takes two or three applications of the oven cleaner (with scrubbing in the utility sink in between applications). Anyone know of a quicker and easier way of cleaning these grates?
Anne P.


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Topic: F5U vs. Xeloda
Hi all,
Does anyone know why some Dr.s treat with F5U, and some with Xeloda, when I've heard that they are the same thing? -and F5U is so much more difficult to treat with because it is a 2 day long IV. My husband's Dr. treats with Xeloda, and when we requested trying F5U, he said it was the same thing, but I'm wondering if we're missing something.


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Get the Recipe
The idea for this cake started with a mad scheme to shellack the case base with chocolate and marshmallows, then outfit it with lightning bolt-like shards of brittle and other Halloween-inspired over-the-top additions. And then I made the cake and took a bite. It was pillowy, moist, and tender, with autumnal flavors that lingered well after the last crumb had been cleaned off the plate with a decisive jab of an index finger. This cake didn't need to be tricked out. It would have been a waste to draw attention away from it with toppings, and so it lies under only a light dusting of confectioners' sugar.
Though this recipe arrives during the Halloween season, it is a cake well-suited for any of the upcoming holidays. It's made warm with allspice, cinnamon, and cloves. Freshly grated ginger cleanly cuts through and comes to the forefront of the cake. Along with bittersweet, heady molasses and pumpkin puree, this becomes something more than the run-of-the-mill dusty spice cake. It is much more nuanced, delicate, and decidedly grown up.
Get the Recipe
About the author: María del Mar Sacasa is a recipe developer, food stylist, and author of the food blogs High Heels & Frijoles and Cookin' and Shootin'.
Behind her girly façade lurks a truck driver's appetite. Read about her cravings and suffer through her rants on Twitter @HHandFrijoles and see her constant stream of food images on Instagram: mdmsacasa