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Click on a thumbnail to go to Google Books.
Unbowed: a Memoir (2006)
by Wangari Maathai
No current Talk conversations about this book.
I really loved this book. She is such a strong and inspiring person.
RIP Wangari. ;(
Wangari Maathai is a Kenyan activist who won the Nobel Peace Prize in 2004. She founded the Green Belt Movement, planting trees across Kenya to stop the soil erosion resulting from deforestation during the colonial years. She was vocal on both women's and environmental issues, challenging the government and organizing protests.
While her life has been interesting and her contributions significant, my attention flagged halfway through. The writing was uninspired, often with extraneous detail. There was little insight to her personal life and emotions, so she came across as single-minded. About two thirds of the way through this book, I set it aside to read something else. When I picked it up again I still couldn't get into it, and skimmed the last 100 pages.
Beautifully written and captivating true story. This is an author and woman to watch.
Unbowed is the memoir of Wangari Maathai, a Kenyan woman who founded the Greenbelt Movement and in the process took on what seemed at times like the entire Kenyan government. The book describes her life in beautiful poetic detail from her childhood in a small village, to her life at boarding school and then in America for college, and then her return to Kenya and her struggles to assert herself there. Along the way she describes all special things that she did or that happened to her. From the outset Maathai makes it clear that she is special and was born that way. This constant building up of herself is furthered by the first person narrative, which prevents the opinions of others from coming through. Considering the kinds of political and personal controversies she has been involved with, this is a rather pressing flaw. Because or in spite of this however, Unbowed is the kind of book that never stops being interesting, no matter what the author is talking about. It is the village kid made national hero story for the modern age, and considering the effect that Maathai has had on the environmental movement, an important story too.
References to this work on external resources.
Wikipedia in English (2)
Amazon.com Product Description (ISBN 0307275205, Paperback)In Unbowed, Nobel Prize winner Wangari Maathai recounts her extraordinary journey from her childhood in rural Kenya to the world stage. When Maathai founded the Green Belt Movement in 1977, she began a vital poor people's environmental movement, focused on the empowerment of women, that soon spread across Africa. Persevering through run-ins with the Kenyan government and personal losses, and jailed and beaten on numerous occasions, Maathai continued to fight tirelessly to save Kenya's forests and to restore democracy to her beloved country. Infused with her unique luminosity of spirit, Wangari Maathai's remarkable story of courage, faith, and the power of persistence is destined to inspire generations to come.
(retrieved from Amazon Thu, 12 Mar 2015 18:25:14 -0400)
The recipient of the 2004 Nobel Peace Prize describes her life as a feminist, political activist, and environmentalist in Kenya, detailing the 1977 establishment of the Green Belt Movement and her role in the transformation of Kenya's government.
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text:
Product Pathways - NF-kB Signaling
IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Biotinylated) #7543
PhosphoSitePlus® protein, site, and accession data: IkB-alpha
|100 µl (10 western blots)
|In Stock
|carrier free and custom formulation / quantity
|email request
|MW (kDa)
|Human, Mouse, Rat, Monkey, Bovine, Pig, Guinea Pig
|Mouse IgG1
Species cross-reactivity is determined by western blot using the unconjugated antibody.
Applications Key: W=Western Blotting
- 7543:
- Western Blotting
Specificity / Sensitivity
IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Biotinylated) detects endogenous levels of total IκBα protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a GST-IκBα fusion protein corresponding to the amino terminus of human IκBα protein.
This Cell Signaling Technology antibody is conjugated to biotin under optimal conditions. The biotinylated antibody is expected to exhibit the same species cross-reactivity as the unconjugated IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) #4814.
The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8).
- Baeuerle, P.A. and Baltimore, D. (1988) Science 242, 540-6.
- Beg, A.A. and Baldwin, A.S. (1993) Genes Dev 7, 2064-70.
- Finco, T.S. et al. (1994) Proc Natl Acad Sci USA 91, 11884-8.
- Brown, K. et al. (1995) Science 267, 1485-8.
- Brockman, J.A. et al. (1995) Mol Cell Biol 15, 2809-18.
- Traenckner, E.B. et al. (1995) EMBO J 14, 2876-83.
- Chen, Z.J. et al. (1996) Cell 84, 853-62.
- Karin, M. and Ben-Neriah, Y. (2000) Annu Rev Immunol 18, 621-63.
Application References
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know!
Companion Products
This product is intended for research purposes only. The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

subset: commoncrawl


text:
Jefferson County, Florida- September 10, 2012
On September 10, at 9:45 am, a collision occurred between a vehicle and a pedestrian.
Laticia Ann Slaughter, 32, of Perry, Florida was driving a 2011 Honda UT, northbound on US 27. The UT was traveling in the outside lane, and crossed the lane edge line striking a pedestrian.
The pedestrian was Carol Hernandez, age 35, also of Perry, Florida. Hernandez had been walking in the paved shoulder area off the highway. She has been transported to Tallahassee Memorial Hospital and is listed in serious condition.
FHP reported to the scene and Jefferson County EMS and Sheriff's Office assisted at the scene.


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Rock Band High Flight Society Mourns the Unexpected Loss of Their Drummer
On the morning of May 20th, rock band High Flight Society's beloved drummer Scotty Lockridge passed away unexpectedly. The announcement was made via their Facebook page.
Open to all, the viewing was held on Wednesday May 23rd and the funeral on Thursday at The Cedartown Church of God in Cedartown, GA.
Band members Jason Wilkes, Michael and John Packer have been received much support in the past week from family, friends, fans and even strangers.
Heartfelt messages from fans were sent to the band members in response to the sad news.
"At least we all know he's making God laugh with his crazy antics. You left behind such a great inspiration Scotty, maybe if the story is true it'll be you drumming in heaven when we hear thunder," wrote Kaitlyn Reese on their Facebook page.
Another Facebook fan Patti Hamilton wrote, "Such loss and devastation in this world. But we know there will be a sweet reunion in that glorious Kingdom to come. Praying for Christ's strength, peace and comfort for all of you now."
BREATHEcast encourages you to say a little prayer for the band and for the family members of Scotty Lockridge.
BREATHEcast RECOMMENDS
Colton Dixon to Collaborate with Leeland, Melinda Doolittle and Tricia Baumhardt of Superchick?
Starfield Selling Their Rarest Collection You Can Get
Colton Dixon Received Surprise Honor of 'Colton Day' Declared by Mayor of Murfressboro
Hyland Filming an Exclusive Acoustic Video
Facedown Records Announce New 'More Than Sound Tour' Headlining War of Ages
Fans Help Unlock Owl City's New Album 'The Midsummer Station' Art
Jimmy Needham Starts a 2-day Blog Topic on Lust & Porn Addiction
Third Day's Mac Powell To Release Solo Country Album
Michael W. Smith Encourages Fans to Vote for His Favorite Hockey Player


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Board of Directors
Nap Hosang
Board President
Dr. Hosang is a founding member of the Center for Entrepreneurship in International Health and Development (CEIHD), now Impact Carbon. Nap is a faculty member at the School of Public Health, UC Berkeley, where he is also on the steering committee of the campus-wide Center for Global Public Health, with a special interest in the management of maternal and child health outcomes in poor, rural communities. He is also a practicing obstetrician/gynecologist in Northern California (with Kaiser-Permanente). Nap earned his medical degree in Jamaica, and his MPH and MBA from the University of California, Berkeley.
JoAnn Dunaway
Board Secretary
JoAnn has an extensive background in management, management consulting, and development in a variety of industries including information systems, financial services, and manufacturing. Areas of expertise include strategic institutional partnerships, cross-cultural management, business development within emerging economies, coordinating complex fund-raising initiatives, and management of professionals. JoAnn holds an MBA from the Haas School of Business at the University of California, Berkeley.
David Charron
Board Treasurer
David Charron is Executive Director of the Berkeley Innovative Leader Development Initiative and Interim Executive DIrector of the Lester Center for Entrepreneurship and Innovation at the Haas School of Business at Berkeley where he lectures on entrepreneurship. He has been working in the field of entrepreneurship and innovation since 1987. David holds a B.S. degree in Mechanical Engineering from Stanford University and an MBA from the Haas School of Business at the University of California, Berkeley
Arno Hesse
Arno is the co-creator of Bernal Bucks, a local money pilot highlighting the economic livelihood of the Bernal Heights neighborhood in San Francisco. The initiatives provides bonuses for residents who buy local, lowers transaction fees for businesses, and also helps fund community projects. Arno is also the Founder and Execution Strategist of ActEdge, where he formulates and executes marketing strategies and works on market entries, re-positioning, segmentation, launches, organic growth and mergers. Arno holds an MBA from the Haas School of Business at the University of California, Berkeley.
Stefan Maxwell
Stefan serves as the director of the Pediatrix Medical Group, Neonatal Intensive Care at Women and Children's Hospital in Charleston, WV and also as clinical assistant professor of pediatrics at West Virginia University School of Medicine. Stefan Maxwell, M.D. has a BSc and a medical degree from the University of the West Indies.


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Bankruptcy Law
Bankruptcy Law Questions? Ask a Bankruptcy Lawyer Now.
i qualify easily, but can you recommend a lawyer who will take payments? recently out of the military and currently enrolled in college, funds are limited but steady. I am in the San Fernando valley area.
DISCLAIMER: Answers from Experts on JustAnswer are not substitutes for the advice of an attorney. JustAnswer is a public forum and questions and responses are not private or confidential or protected by the attorney-client privilege. The Expert above is not your attorney, and the response above is not legal advice. You should not read this response to propose specific action or address specific circumstances, but only to give you a sense of general principles of law that might affect the situation you describe. Application of these general principles to particular circumstances must be done by a lawyer who has spoken with you in confidence, learned all relevant information, and explored various options. Before acting on these general principles, you should hire a lawyer licensed to practice law in the jurisdiction to which your question pertains.
The responses above are from individual Experts, not JustAnswer. The site and services are provided "as is". To view the verified credential of an Expert, click on the "Verified" symbol in the Expert's profile. This site is not for emergency questions which should be directed immediately by telephone or in-person to qualified professionals. Please carefully read the Terms of Service (last updated February 8, 2012).


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Capita Symonds has four speakers at this year's Ecobuild, the
world's biggest event for sustainable design, construction and the
built environment:
▪ Seminar – Tuesday 1st March,
10.45-12.15, North Gallery Room 10
Refurbishing Britain: A plan for every
Anthony Petrilli, Capita Symonds, will be
speaking on 'Implications for construction sector.'
▪ Seminar - Tuesday 1st March,
15.45-17.00, North Gallery Room 6
Regulations Revealed: CRC Energy Efficiency
Scheme – beyond the introductory phase.
Suzanne Roberts, Capita Symonds, will be
speaking on 'Latest update on the scheme: who does it apply to,
what are the qualifying parameters and resulting obligations, how
does it work, key dates and phases?'
▪ Fringe - Tuesday
1st March, 16.15-17.00, UK-GBC Theatre
Lisa Skinner, Capita Symonds, will be taking
part in the session: 'Community Engagement: Exciting Or
Excruciating?: Will the Localism Bill make community engagement
exciting or excruciating?'
▪ Seminar – Thursday
3rd March, 14.15-15.45, South Gallery Room 29
Energy in Buildings: The future's efficient,
the future's smart.
Yianni Spanos, Capita Symonds, will be
speaking on 'Smart metering specification and roll out update.'
For further information go to www.capitasymonds.co.uk/ecobuild2011
Ecobuild – www.ecobuild.co.uk –
takes place from Tuesday 1st March to Thursday 3rd March at ExCeL,
Capita Symonds' 'Cool
Workspace' installation (pictured above) is situated at S240,
entrance S1.
Capita Symonds to Unveil Office Nightmares
Ecobuild 2012
See all events


text:
COLUMBUS, Ohio (AP) — The American Civil Liberties Union says it is joining third parties in Ohio in opposing a fast-moving bill that sets new hurdles to ballot access in the battleground state.
The legal organization planned to testify against the bill Tuesday. Representatives of the Green and Libertarian parties also were scheduled to speak against the proposal at the Statehouse hearing.
The Republican-controlled Ohio Senate could vote as soon as Tuesday on the measure, sending it to the House.
The bill introduced in September by Cincinnati Republican Bill Seitz (syts) comes as Ohio Republicans face growing competition from tea party supporters. They say they may support a third-party challenger to Gov. John Kasich (KAY'-sik) in next year's governor's race.
Seitz says the legislation updates minor party rules in the wake of a lawsuit.


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Graham Sterling Starr - March 11, 2010
Bart and Monica Starr of Kansas City, Mo. are the proud parents of a son, Graham Sterling Starr, born March 4, 2010 at St. Luke's Hospital in Kansas City.
Graham weighed 7 pounds 11 ounces and was 19 1/2 inches in length.
Grandparents are Bob and Gail Starr of Lincoln, Neb. and Garvin and Connie McClenahan of Grant, Neb.
Great-grandparents are Herman Heart of Cozad, Neb. and Doris McClenahan of Grant.
Welcoming him home is big sister Iris Olivia soon to be two years old.


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Chronic Back Pain Breakthroughs
Ouch, that aching back! If you've ever moaned in agony from back pain, rest assured—albeit uncomfortably—that you're not alone. About eight in ten Americans will suffer from it at some point in their lives. After colds, it's the No. 1 cause of missed work. It's a major drain on the American economy, costing more than $90 billion a year in medical bills. Yet a cure for the common backache is as elusive as ever.
Part of the problem is the complexity of the spine, a miraculous structure of bone and cartilage that surrounds nerves linking the brain to the rest of the body. The lower back, called the lumbar region, bears most of a person's weight on five vertebrae separated by disks that work like shock absorbers to provide cushioning and flexibility. Muscles and ligaments supply further support. But over time, the effects of aging decrease bone mass and muscle elasticity, and contribute to disk degeneration, leaving the lower back vulnerable to injury—and millions of people susceptible to pain.
Back pain can originate from many sources, and treatments are just as varied, from conservative approaches like exercises and massage, to more risky prescription medications and surgery. Unfortunately for many patients, these choices often provide only temporary relief, and some have debilitating side effects.
But the search for a magic bullet continues, and we may be closer than ever. Doctors and scientists are reporting success with these new and coming-soon treatments that can ease back pain for some sufferers while offering hope to all.
Next: This "pain pacemaker" blocks back pain to the brain
Thanks! You're on our list.
And about to get a whole lot healthier.
Just found the worst page in the entire dictionary. What I saw was disgraceful, disgusting, dishonest, and disingenuous.
Client: We need you to log in to the YouTube and make all our company videos viral.
From clientsfromhell.net
My cat just walked up to the paper shredder and said, "Teach me everything you know."
"Just because you can't dance doesn't mean you shouldn't dance." —Alcohol
@yoyoha (Josh Hara)
My parents didn't want to move to Florida, but they turned 60 and that's the law.
—Jerry Seinfeld
Q: What do you call an Amish guy with his hand in a horse's mouth?
A: A mechanic.


text: Haven't been posting for a while, but I'm still riding. Sad to see all the hatin' on riding around Atlanta. My biggest complaint is road condition. My commute takes me through East Atlanta, Reynoldstown, Old 4th Ward, Midtown, Piedmont Park to around Ansley. There are ways to avoid most of the worst streets. That said, this afternoon on the way home, I just busted it right down Peachtree St., mostly to avoid the aftermath of the Dogwood festival in the park. And it was awesome. School buses, police cars and people that live in the suburbs are the worst to ride around in that order. If anyone needs help avoiding bad streets in those areas, I'd be happy to try and help.


text:
Images: US Air Force Academy Football [Image 9 of 12]
Photo by Michael Kaplan
Falcon head coach Troy Calhoun leads the U.S. Air Force Academy Falcons into Falcon Stadium as Air Force met conference rival Wyoming at Falcon Stadium in Colorado Springs, Colo., Sept. 21, 2013. The Cowboys defeated Air Force 56-23. (Air Force Photo by Mike Kaplan/Released)
This work, US Air Force Academy Football [Image 1 of 12], by Michael Kaplan, identified by DVIDS, is free of known copyright restrictions under U.S. copyright law.
Date Taken:09.21.2013
Date Posted:09.23.2013 14:53
Photo ID:1024276
Size:2.14 MB
Location:U.S. AIR FORCE ACADEMY, CO, US
Hometown:MCMINNVILLE, OR, US


text:
Download Educational Comics that Align with Common Core!
The Cool School Rap is a downloadable educational comic series that breaks down science concepts for grades 4-8. Aligning with the new Common Core standards, The Cool School Rap guides students' learning through word bubbles, illustrations, examples, and diagrams. The Cool School Rap also promotes inquiry in science with the incorporation of "Inquiry Ideas" within many individual comics and accompanying comics that are written in the packages.


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Naval museum likely to claim bomber if it is raised
San Diego Is a custody battle likely between two aviation museums for the rare Navy SB2C-4 Helldiver bomber that's been resting on the muddy bottom of Lower Otay Reservoir?
Probably not, said retired Capt. Bob Rasmussen, director of the National Naval Aviation Museum in Pensacola, Fla.
Reached Friday at the museum, Rasmussen said it's "unlikely" that the San Diego Air & Space Museum will permanently keep the plane, which crashed in 1945 and remains buried in mud at the reservoir.
James Kidrick, president and chief executive of the San Diego museum in Balboa Park, said Friday that he would like to see the plane stay here.
Not happening, Rasmussen said.
"There are certain circumstances where it might be there for a while," Rasmussen said. "But fortunately, the Navy owns the plane. We may be able to arrange for it to be there (in San Diego) on loan for a while. But I told Jim that he'll get it when I'm 150 years old. The bottom line is this plane is rare, and this is the national aviation museum. It belongs here."
Rasmussen said both museums enjoy a tremendous working relationship in which the San Diego museum has planes on loan and has even restored planes for the Pensacola-based national museum.
"Several years ago, they did restoration work for us on a plane that was brought up out of the Pacific Ocean," Rasmussen said.
A&T Recovery, a Chicago-based company, has been contracted to examine and possibly raise the Helldiver.
The bomber, nicknamed "Big-tailed Beast" by those who flew it, was deemed to be intact by A&T divers who inspected it Thursday. Sensors will have to be used to determine if the plane is intact below the mud.
Rasmussen said Friday that he looked at some video shot by A&T diver Keith Pearson and expects a preliminary report from A&T owner Taras Lyssenko later Friday.
He said he could make a decision on whether to recover the plane as soon as Monday afternoon.
"I've looked at a few pieces of video, but I haven't made any decision yet," Rasmussen said. "I'm awaiting their preliminary report.
"I'll take the report and take some time with it, chew on it a little bit. But I need to remind everyone that it's going to be a while before anything is done. Even if I say let's do it, there are a bunch of hurdles to jump through before we see that plane. I'm hopeful we're going to get it. I'm optimistic."
Pearson spent an hour Friday morning at the Helldiver site, which is in 85 feet of water roughly 200 yards southeast of the boat dock and about 300 yards from shore.
Visibility is very low on the reservoir floor, he said, and it turns to zero with "one fin kick."
"I took video around the airplane, and it's buried up to the cockpit and the cockpit is full" of sediment, Pearson said.
His dive was followed by one from a the Navy's Mobile Diving and Salvage Unit 1. In the afternoon, Pearson descended again to snap photos and record video footage of the aircraft.
The divers were accompanied by ranger-divers from San Diego's lakes system.
Thursday's examination stemmed from an incredible discovery in February, when bass fishermen Duane Johnson and Curtis Howard spotted the plane on Johnson's Humminbird fish finder.
Johnson alerted Otay Lakes reservoir keeper Bryan Norris, who brought in the Navy after a remotely operated vehicle revealed that the Helldiver belonged to that service.
Based on preliminary photos and video, the Navy traced the aircraft's history to May 28, 1945. The bomber's engine failed during a practice mission and pilot E.D. Frazar made a wheels-up, flaps-down forced landing. He and gunner Joseph M. Metz swam to shore.


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|Cape Life
|Apr 06, 2013
First Semi-Annual Bowling and Cornhole Tournament, 10 a.m., 1103 S. Central Avenue, Laurel. Half of proceeds will benefit the Delaware Breast Cancer Coalition. Cost for team is $50 per team; $25 person. Registration forms available at Bryan's Bowling Center, 1103 South Central Ave., Laurel and at bryansbowlingcenter.com.


text:
Imad Jandali, MD is Board Certified in Pediatrics and received his medical degree from theUniversity of Alexandria.
Dr. Jandali completed his Internship and Residency inPediatrics at Jacksonville Health in Florida.
Dr. Jandali specializes in pediatrics at Regional Medical Center Bayonet Point and is a practicing pediatrician atAll Pediatric Care, PA in Spring Hill, Florida.


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14/03/2008/2:51 pm, Little Farmers Cay
We thought we had seen the best of the Bahamas - the water, the sky, the friendly people, and then we moved again and saw even more. These Exuma Islands are so full of beautiful communities; we just keep shaking our heads and marveling.
After a day of "housekeeping" jobs in Black Point, we headed back to Madcap to make an early night of it - stopping on the way to chat with Laurie and Frances (Glory Days). They return to Manotick, ON each summer and are old hands at spending winters in the Exumas. One thing we were pleased to hear them comment on was the value of making the first trip a shakedown cruise. We sometimes wonder if we should have made additional purchases before we left, but they supported the idea of finding out what we need and don't need, and then getting it for the next time. It's the old "Just GO" thing. Too often, when would-be cruisers wait until they have every single item purchased and every detail planned, something happens and they don't make the trip at all. There are boaters here in every kind of vessel - beautiful or weathered - with up to the minute technology or with paper charts and VHF only - with all the mod cons or with the bare minimum.
We tucked into the southeast end of Little Farmers Cay again and tied up to an Ocean Cabin mooring. After settling ourselves down, we took a run over to say hello to our neighbours, Abbie, Jeff and little 9-month-old John on Last Paradise. Now there is a young family with adventure in their blood. Hailing from Michigan, they're full-time cruisers with experience in the South Pacific and with plans to sail back to New Zealand. When we admired their courage, Abbie just smiled and said "Captain John" is a fine sailor who requires them to adjust their timetables, but not their cruising lifestyle.
Ashore, we strolled up to Ocean Cabin to pay our $10.00 per night for the mooring and see who might be about. We found three very cheery fellows in the tiny bar - all from the Bahamian Patrol vessel we had seen tied up at the dock. We joined them and spent the next hour in gales of laughter as they joked and teased. Conversation ranged from their jobs (keeping an eye out for boats smuggling drugs or humans) to our itinerary, to their favourite methods of making peas'n rice, to the Family Islands Regatta at the end of April, with a whole lot of good-natured ribbing of each other and of us. The Peas'n Rice bit was fascinating - I don't even remember quite how we got into it, but I mentioned that I'd been experimenting with ways to prepare it and all of sudden, two of them were telling me how they make it. These men know their way around a kitchen!
Cruisers kept strolling in... Sandy and Dana (Sol Purpose), Bruce and Carla (Deuces Wild), Jim and Nancy (Solitaire) and their guests Lori and Dana, Jeff and Abbie and John (Last Paradise). Terry and Ernestine Bain are the owners of Ocean Cabin and they kept everyone supplied with Kalik, all the while accepting reservations for dinner and directing VHF callers to their moorings. Their daughter, Khadejah, arrived in from school and flung her arms around her parents with a big hello. Two other daughters are in Fort Lauderdale - one in high school and one in university. We saw some pictures and they are all lovely.
On the way back to the dock, we stopped to request some fish from Jeffery and he later met us at the beach with freshly caught grouper fillets and a bag of lobster tails. Oooh - we'll eat well for a few days. For dinner, I pan fried the grouper and made a new kind of rice and beans - this one with kidney beans and coconut milk - and a bowl of cole slaw. My plan had been to make a banana cake but the warm breeze and starry night made me want to get out of the galley. Perhaps tomorrow...
Friday night ended with full stomachs, and full hearts - full of this beautiful place with welcoming Bahamians, the camaraderie of fellow cruisers, the caves and coral heads and fishing spots we'll explore over the next few days. Tomorrow is the All Age School Fair - with games and food and music.
The wind has pretty much died down and we'll have a few days of light and variable wind before the expected northerly on Sunday night and Monday. This may be a very good spot to be tucked away.
13/03/2008/11:39 am, Bitter Guana Cay
We spent a couple of nights at Bitter Guana Cay instead of going straight to Black Point Settlement. We had noticed this anchorage a couple of times but had never stopped there until prompted by Strathspey, and we're really glad we joined them.
It's a beautiful little bay bordered by snowy white cliffs rising high above a sandy beach.
There is plenty of clear green water close to shore, iguanas on the beach and white-tailed tropicbirds in the air, and an osprey perched on the cliff. What a delight! One tropicbird circled overhead just as we were anchoring, and the next morning 6 or 7 were circling around. These are white birds with bland bands on their wings and long streaming white tails - very distinctive. We wonder if they are curious too - the only time we saw them flying about was when boats were entering or leaving the anchorage. It is nesting season so we might all have been considered intruders.
Jim donned snorkel gear, checked our anchor and continued on to the beach where I joined him and we had a stroll with the iguanas. One of our books mentioned that there had once been iguanas there, and the Explorer chart notes that it is a protected habitat. Sure enough, we found quite a colony of them - every bit as large and prehistoric-looking as the ones on Allan Cay. Some are assertive -or perhaps just greedy. They came rushing at anyone who stepped on the beach, but we found they stopped about a foot away. We're pretty sure they were looking for handouts and when they discovered we had nothing for them and were not threats, they pretty much left us alone.
Jim helped Mary winch Blair to the top of their mast to check the VHF radio connection while I took pictures from Madcap, and then they joined us for champagne and munchies to honour Blair's approaching birthday and the probable conclusion of our travels together on this trip. Once they have enjoyed the company of their children in this area, they will head north, while we continue on our journey southward for another month or so. It is hard to believe that it has been over 8 months since Strathspey and Madcap left Ontario together. Since then, we've traveled together off and on as we each "followed wind, weather and inclination" as Jim is fond of describing our itineraries. As they headed out of the anchorage on Wednesday morning, we waved them off with regret; it is unlikely that we will have any more sightings of Strathspey or hear the sounds of the pipes at dusk on this trip.
Midwatch and Renaissance left as well - the water had gotten quite rolly - and we had the place to ourselves. Because the forecast was for the wind to drop over the course of the day and most nearby anchorages were also open to the west, we opted to stay here. We went ashore, picked our way through the sea grapes and grasses to the eastern side where it was lovely and calm. After a swim, we put our attention to a search for sea beans, and I found one! Beachcombers prize these beans, and I've been looking unsuccessfully for a while; the only other one I spotted was in the park and I had to leave it there.
Sea beans are washed onto these shores from trees throughout the Caribbean, Central America and South America (and occasionally from Africa) and so it seems something of a marvel to pick one up. While there are lots of nuts and drift seeds to be found, the keepers are the shinies - hamburger beans, sea purses, sea pearls and sea hearts. My particular bean is a sea heart - not really heart shaped but with a slight indentation in the top - a rich dark brown and about 4 cm across. Sea hearts grow on vines called "monkey ladders" in the Costa Rican forests.
The wind stayed up at 10-15 knots from the west all day giving us quite a bouncy time of it. We kept discussing the possibility of moving but whenever we monitored a radio conversation from Big Majors Spot or Black Point, we heard complaints of rough water so we thought we might as well continue where we were.
We managed to read our books and I made Chicken Souse - pretty much like a Canadian chicken stew with lemon juice and hot sauce added - for dinner. The wind did lay down a bit so that our night was reasonably comfortable.
We moved this morning - Thursday - to Black Point for laundry and internet. Then we are headed to Little Farmers in time for the All Age School Fair on Saturday. Well ...that is the plan...unless wind, weather and inclination cause another change!
10/03/2008/10:31 pm, Staniel Cay
We watched the giant ship, Mystique, pull out of Sampson's Cay as we drank our morning coffee. Despite its huge superstructure, it apparently draws only 4 feet, and with its powerful engines and thrusters, it turned on a dime. We spotted the owner down on the lower deck and a female passenger watching from an upper deck, and at least 7 crewmembers releasing lines and scurrying about. The captain was high above at the controls. Yesterday the crew wore white golf shirts and navy shorts and spent a lot of time polishing stainless and cleaning windows. Today, under grey skies, they sported navy shirts and khaki pants as they attended to the business of departure. This is the shakedown voyage for the ship - according to the gossip we collected on the dock; the owner has had it for only a few weeks and is taking a little trip around (480 gallons of fuel an hour - no sails) before it goes back to the states to be totally renovated inside.
Now Jim and I try quite hard really to be non judgmental, but it seems almost incomprehensible that this giant ship - 164 feet long - is for the use of two people and needs to be gutted and redecorated. Does it "need" that overhaul, or will hundreds of thousands of dollars be spent just to reflect the tastes of new owners? We had a few other words come to mind as we contemplated the dollars and materials and the size of the footprint, but suffice it to say ... it is hard for us to understand how so much money could be spent on a boat.
We have met cruisers who are out here exploring the Bahamas with very little money and on boats without all the bells and whistles - some of them only 27 - 30 feet in length. Our suspicion is that they are just as happy and having just as good a time.
After lovely eight minute showers (token - $4.00) we pulled up our anchor and headed back to Staniel Cay. The parts Jim ordered to fix our head (toilet) were delivered to the Yacht Club by Watermakers Air so he has his next little job lined up. The problem seems to be that the hand pump has lost its prime. Maybe a leak in the seal? We hope it is a straightforward fix.
It felt almost like coming home as we pulled into our customary anchorage just in front of the yacht club. We dinghied ashore to make a couple of phone calls and met up with several cruisers we've seen in other places. I took a walk down the road past "our" cottage - Atlantica - and up to Brenda's house where I bought a loaf of cinnamon-raisin bread. Her hand lettered sign, "Bread" rests on a lawn chair outside her door whenever she has been baking, and we have enjoyed many loaves from her oven. I stopped to chat a bit with her and with Rhonda, the woman who was so kind to us all, and particularly to Margaret when she visited here with Pat and Sean. Rhonda was a great connection for Marg when the rest of us went off on the boat to the park for a couple of days.
I strolled on up the hill to the Pink Pearl Store to visit with Miss Flo and to pick out one of her baskets to bring back to the boat. She and her daughters plait the local fronds of grass into mats and baskets. Most of them are flat but I like the round coils, done with a needle. Some are made from sisal, some from silver top. Last week, I watched some women in Black Point sit in the shade, plaiting (pronounced platting) the long ribbons of grass that are then sent off to Nassau and made into baskets, placemats, floor mats, and lots of other creations
There was something very satisfying about being able to walk from dock to house to store, saying a farewell to people we've gotten to know, however briefly, in the time we have been visiting in this area. A few roosters wandered around yards; people waved from porches; laughter rolled along the dock from the fellows who work at the yacht club. It seemed a far cry from the conspicuous consumption we had seen earlier in the day. I know which I like better. As I left, Flo told me I have a good husband, and when I reported that comment back to Jim, he thought she was very perceptive!
There aren't very many boats here tonight - just three of us in our usual spot at the edge of the channel, and another 3 or 4 in closer to the shoreline. We spotted some masts over near Club Thunderball, and counted about 20 boats in Big Majors Spot as we came by.
It is amazingly still tonight - no wind to speak of at all - a marked difference from the last 2 or 3 days when the wind has hardly dropped below 15 knots, and although it's been overcast much of the day, there have been only a few sprinkles of rain.
The darned old generator is working away on the foredeck and I'm trying to stop resenting it and be grateful that it does some good for our sluggish batteries. That problem is still hanging over our heads - how is it that they lose their charge so rapidly? We have no freezer, no water maker, no air-conditioning, the fridge is on the lowest possible setting, we are using LED battery powered lanterns now instead of our mast top anchor light at night and we plug in the computers only when the engine is on or the generator is running. How can energy be such a huge issue???
We'll meet up with Strathspey here in the morning before going to Black Point for a day or so.
I am a long way away and I expect you have had lots of suggestions but I keep wondering if the Diodes in your alternator are leaking. Have you tried isolating it or unhooking it when the engine is not running to see if a charge will last longer?


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Power your gaming machine with the Cool Power Gamer CP-G880 ATX power supply! The CP-G880 features 880-watts of power and a super silent 4.72-inch (120 mm) fan that lights up with a cool blue LED. This Gamer Series power supply is equipped with one 20+4-pin ATX power connector, one 4+4-pin EPS/ATX power connector and two 6-pin PCI Express power connectors! Six SATA power connectors, six large Molex 4-pin power connectors and two small floppy power connectors provide enough power for several storage drives! Other features include over current protection, over voltage protection, short circuit protection and much more! Get up to 880-watts of power with this Cool Power Gamer CP-G880 ATX power supply!
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Good PSU for the Price
By Al
from San Antonio, TX
About Me Heavy Duty User
Best Uses
Comments about Cool Power Gamer Series CP-G880 880W 20+4-pin Blue LED Fan ATX Power Supply w/SATA, PCIe & Dual 12V Rails (Black):
Good high power PSU for the price. However, of the two I purchased in Oct. 2012, one has already shorted out and smoked. The other continues to run well.
Service and delivery comments:
Delivery was as stated when ordered.
Bottom Line No, I would not recommend this to a friend
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Get it works
By GEEK
from Portland OR.
I have mine running a 5870 and a 6950 and a 670 have had no problems now over a year fantastic P.S.
Bottom Line Yes, I would recommend this to a friend


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I have been playing and teaching slide guitar now for quite some time (I'm even starting my new "Slide Guitar Summit" album next week), and I can certainly say that there are no shortcuts when it comes to what the right, or picking hand must do to make you a good slide player! Like other finger-style approaches, slide guitar is very dependent upon one being able to "isolate" the strings you want to play, and to minimize accidental sounds caused by other strings being sounded by the slide.
This is the kind of feat that is either easily and naturally "fallen into" or it's something that can take painstaking years of trying until it becomes "natural" to you. For some reason, when I wrote my first book, Slide Guitar, when I was just 20 years of age, it actually amazed me just how much I had already come to know about using the proper techniques when it came to blocking and dampening for slide guitar! It absolutely had to have come to me very naturally, because I was so completely self-taught, and as of yet had not really been exposed to many other players who could've influenced me. On recordings yes….Son House, Elmore James, Robert Johnson and many others certainly influenced the sounds I was after, but I never got to really watch or be taught by anybody. No doubt, a small amount of early Classical guitar had to have helped my right-handed abilities, and the fact that my teacher always promoted "accent" strokes, and being sure to land your thumb as well as other fingers on adjacent strings wherever possible.
There's little doubt that this emphasis on the "accent stroke", where one lands on the adjacent string helped me in becoming a good "dampener" when it came to isolating strings. Now of course, many of the early slide players actually played in a rather "hard" and primitive manner, where many strings were struck at the same time. I took an immediate interest in the Dobro and lap steel styles early on too, so I think that also may've helped me become a more "accurate" finger-picker when it came to slide styles, and to this day I enjoy all three approaches; Dobro, lap steel and "upright" slide!
So, be sure to watch my Gibson lessons, read my Slide Book (Oak Publications) and even my Hot Licks videos, and pay close attention to that right hand! It is the main thing that will enable your slide playing to go from just "adequate" to GREAT!
Gibson.com's Arlen Roth, affectionately known The King of All Guitar Teachers, is music lesson pioneer and the quintessential guitarist. An accomplished and brilliant musician — and one of the very few who can honestly say he's done it all — Roth has, over the course of his celebrated 35-year career, played on the world's grandest stages, accompanied many of the greatest figures in modern music and revolutionized the concept of teaching guitar.


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YES Special Course on Smart Energy Systems: Policies, Practices, and Technologies
7th-19th September 2014
Bremerhaven, Germany
Download detailed course program and faculty list (pdf, 0.2 mb)
Download course call (pdf, 0.7 mb)
Course Outline
Shifting paradigms on energy systems is one of the most important challenges towards a sustainable future. While the current focus is primarily driven by the "energy mix agenda" – from fossil to renewable energy sources – it is necessary to redesign energy systems as a whole. The YES Special Course on "Smart Energy Systems" provides deep insights into systemic design principles, energy and climate technologies and policies, participative social change, and best practices.
Course Audience
The course ist directed to graduate students and young professionals from all disciplines and countries engaged in industries, businesses, professional associations, think-tanks, public administrations, academic institutions, international organizations, and NGO. YES Alumni are especially encouraged to participate.
In the course, participants learn to…
- learn about technological, political and social tools and frameworks towards sustainable energy systems
- enhance skills in business modeling, project design, and management
- strengthen know-how to facilitate transformative processes in society
- work on a tangible case study to "Transform your Country's Energy System"
- live and learn in an inspiring setting outside of Bremerhaven in the middle of agricultural farmland
- visit Europe's largest wind park area
Course Partners
Day-to-day schedule
|Su, 7.9.
|Arrival at Hamburg Main Station, transfer to Bad Bederkesa.
|Mo, 8.9.
|Introduction: Sustainability and the role of smart energy systems.
|Tu, 9.9.
|Energy Systems I: Smart energy systems, technological strategies, renewable energies.
|We, 10.9.
|Excursion Day: Wind energy & socio-economic transformation of Bremerhaven.
|Th, 11.9.
|Energy Systems II: Smart cities and communities, smart grids and crowd energy.
|Fr, 12.9.
|Business Practices: Business Solutions & models for the new energy era.
|Sa, 13.9.
|Policies & Politics I: Climate and energy policies in perspective.
|Su, 14.9.
|Policies & Politics II: Understanding political & social system dynamics.
|Mo, 15.9.
|Energy Systems III: Modeling & linking stakeholder dimensions.
|Tu, 16.9.
|Excursion Day: Climate Science.
|We, 17.9.
|Projects in Practice: entrepreneuring, myclimate cases & a global view.
|Th, 18.9.
|Wrapping up: Group work presentations, reflections, discussions.
|Fr, 19.9.
|Departure: Transfer to Hamburg, visit at EBC University, individual departures.
Core faculty, present during whole course
|Dr. Stefan Gara
|Managing director, ETA Environmental consulting. PhD in physics. Will provide input on policy issues, stakeholder analysis and transformation strategies for smart cities, mobility, energy systems.
|Mr. Klaus Elle
|Artist and freelance educator in art and creativity. Leader for creative activities during the course.
|Mr. Dominik Mösching
|Program manager YES, myclimate education. M.A. political science, PhD candidate in sociology & organization science, University of St. Gallen. Will provide input on political and social dynamics. Course facilitator and YES Alumnus.
Main faculty members, present for 3-7 days
|Prof. Dr. Stefan Schleicher
|Professor at the Karl Franzens University Graz and the Wegener Center for Climate and Global Change. Climate and energy economics, energy transitions and innovative economic structures, emissions trading.
|Ms. Carolin Vierhaus
|myclimate carbon market expert and coordinator for climate projects and energy systems throughout Africa.
|Mr. Rasmus Einarsson
|MSc in engineering and complex adaptive systems. Consultant in energy modeling for cities. Course facilitator and YES Alumnus.
|Dr. Matt Gardner
|Director, Sustainserv Inc. PhD in chemistry and long experience in environmental research and education, Harvard. Will provide input on business models and leadership.
|Madis Org
|Consultant for Spatial Planning and Energy Strategy. YES Alumnus
|Dr. Roger Baud
|Founder YES and ACTIS, PhD in social psychology, ETH Zürich. Long experience in sustainable development.
Additional faculty and speakers
|Dr. Christoph Mayer
|Prof. Dr. Meinhard Schulz-Baldes
|Klimastadt Bremerhaven
|Andreas Huber
|Club of Rome, Desertec Foundation
|Franziska Walther
|Ashoka. YES Alumna
|Klara Lindner
|Hinrich Eden
|SSC Wind
|Dr. Christoph Lattemann
|Jacobs University Bremen
Application closed
- Tuition Fee: EUR 850 for students, EUR 1.500 for professionals (covering accommodation, meals, all local travels, transfers from and to Hamburg, all activities and materials during the program, post-course membership in YES Alumni network)
- Discounts: Applicants from Non-OECD countries -20%, YES Alumni: -15% additionally
- Participants are responsible for the organization and payment of their travel to Hamburg as well as any possible visa and insurance fees
- Admission criteria
- Selection process
The participation fees are considerably subsidized by our course partners.
Limited amount of additional tuition fee subsidies is available. Participants are encouraged to seek further support for their expenses from universities, foundations, corporations or professional associations.
Are you representing an institution willing to send participants? You're welcome! Please contact email@example.com for conditions.


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He and his wife, Kristi, live in Elbert, a small town on the eastern Colorado plains.
Kristi Wysocki told ABC News that, at times, the terrorists were only a few feet from where her husband was hiding. She said she felt that her husband "made it to hell and back."
A family spokeswoman said she wouldn't be doing any other interviews. In the statement, Steven Wysocki asked for privacy as he recovers from the ordeal.
(Copyright 2013 by The Associated Press. All Rights Reserved.)


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Hey look! An interview with Gearbox CEO Randy Pitchford that doesn't go into the kerfuffel surrounding the development and release of Aliens: Colonial Marines!
Of course, that's because this interview with GamesIndustry International was conducted before that game's release. It's a great discussion and it covers many interesting topics from violence in games to how game developers weigh the importance of artistic expression versus what's commercially viable but what caught our eye was Pitchford's comparison of the ESRB and the NRA.
"Think about the world's relationship and the game industry's relationship with the ESRB. The ESRB is our self-regulated ratings body; the industry created this body to put labels on games. Most publishers, we pay for the ESRB, but we also have this high tension relationship. They're really good at their jobs – they hold the industry accountable to fitting within the guidelines of whatever the label is and they will label appropriately. If you cross a line they will put you in a different spot, whether you want to be in that spot or not. And compared to the movie rating system, they have the best awareness and understanding of what their rating system is, and they have the best enforcement. Retail participates. That's awesome."
"Imagine if the NRA was actually advocating for gun laws; imagine if the NRA had the same relationship with the gun industry that the ESRB has with the game industry," he continued. "Instead of the NRA saying don't make any laws, now it would be like, 'F**k, the NRA's making me do all this so my guns are safer, and I get why they're doing it but it's kind of a pain in my ass.' That's how the game industry's relationship is with the ESRB. We love that it's there but we've got to deal with shit; we have to go through a process to get the rating. If we don't the retailers won't stock us, and when some of the content pushes the line a little bit they're going to call us on it and we have to deal with that. Imagine if the NRA had that same relationship with its industry, the rest of the country would be like 'Go NRA!' They could be good guys."
Source (story and pic): GamesIndustry International
-Reporting from San Diego, GamePolitics Contributing Editor Andrew Eisen


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Home > News, Alerts and Tips > News and Alerts
News and Alerts
CDC Finds Salmonella Outbreak Related to Clinical and Teaching Labs
The Centers for Disease Control and Prevention issued it final report on their investigation of a multistate outbreak of Salmonella typhimurium infections on 1/17/12. Their analysis indicates the outbreak was the result of exposure in clinical and teaching microbiology laboratories. The investigation focused on potential risk factors in microbiology laboratories that work with infectious agents like the strain of Salmonella typhimurium. CDC collaborated with state and local health departments, the American Society for Microbiology, and the Association of Public Health Laboratories to conduct a survey to identify areas where improvements in biosafety and laboratory safety training can be made to prevent future illnesses.
Between August 20, 2010 and June 29, 2011, a total of 109 individuals infected with the same strain of Salmonella typhimurium were reported from 38 states . Infected individuals ranged in age from less than 1 year to 91 years old, and the median age was 21 years. Sixty-one percent of patients were female. Twelve percent of patients were hospitalized. One death was reported. Several of those sickened are children who live with someone who works or studies in a microbiology lab.
Please review the advice to lab workers and supervisors from CDC below. For full details on the CDC investigation go to > http://www.cdc.gov/salmonella/typhimurium-laboratory/011712/index.html
Advice to Students and Employees in Clinical and Teaching Microbiology Laboratories
Be aware that bacteria used in microbiology laboratories can make you or others
who live in your household sick, especially young children, even if they have never
visited the laboratory.
- If you work in a laboratory, it is possible for you to bring bacteria home through contaminated lab coats, pens, notebooks, and other items that you use in the microbiology laboratory.
- Avoid taking laboratory supplies outside of the laboratory o to limit contamination.
Persons working with any infectious agents, including Salmonella bacteria, must
be aware of potential hazards, and must be trained and proficient in biosafety
practices and techniques required for handling such agents safely, in particular,
- Wash hands frequently while working in and immediately before leaving the microbiology laboratory and follow proper hand washing practices. This is especially important to do before preparing food or baby bottles, before eating and before contact with young children.
- Leave food, drinks or personal items like car keys, cell phones and mp3 players outside of the laboratory. These items may become contaminated if you bring them into the laboratory or touch them while working in the laboratory.
- Wear a lab coat or other protective garment over personal clothing when working in a microbiology laboratory. Remove protective garment before leaving for non-laboratory areas (e.g., cafeteria, library, or administrative offices). Dispose of protective garment appropriately or deposit it for laundering. Lab coats should be removed from the laboratory only when they are to be laundered by the institution.
- If you work with Salmonella bacteria in a microbiology laboratory, be aware that these bacteria can make you sick. Watch for symptoms of Salmonella infection, such as diarrhea, fever, and abdominal cramps. Call your health care provider if you or a family member has any of these symptoms.
Advice to Laboratory Directors, Managers, and Faculty Involved with Clinical and Teaching Microbiology Laboratories
- A comprehensive set of biosafety guidelines for work with Salmonella and other similar human pathogens can be found in the Biosafety Level 2 section of the CDC/NIH Biosafety in Microbiological and Biomedical Laboratories manual, the Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories MMWR Supplement, and the Guidelines for Biosafety Laboratory Competency MMWR Supplement.
- Either non-pathogenic or attenuated bacterial strains should be used when possible, especially in teaching laboratories. This practice will help reduce the risk of students and/or their family members becoming ill.
- Persons working with infectious agents, including Salmonella bacteria, must be aware of potential hazards and trained and proficient in the practices and techniques required for handling such agents safely.
- Advise all persons working in the laboratory to watch for symptoms of Salmonella infection, such as diarrhea, fever, and abdominal cramps, and to call their health care provider if they or a family member have any of these symptoms.
- All students and employees using the laboratory should be trained in biosafety practices.
- Ensure that handwashing sinks have soap and paper towels. Require students and employees to wash their hands before leaving the laboratory.
- Do not allow lab coats to leave the microbiology laboratory, except to be cleaned by the institution.
- Do not allow food, drinks or personal items like car keys, cell phones and mp3 players to be used while working in the laboratory or placed on laboratory work surfaces.
- Provide students with dedicated writing utensils, paper, and other supplies at each laboratory station. These items should not be allowed to leave the laboratory.
If you work with Salmonella bacteria in a microbiology laboratory, watch for symptoms of Salmonella infection, such as diarrhea, fever and abdominal cramps. Call your health care provider if you or a family member has any of these symptoms.
News and Alerts Archive
- August 24, 2012 - Community Household Sharps Collection
- January 1, 2012 - CDC Finds Salmonella Outbreak Related to Clinical and Teaching Labs
- May 5, 2011 - June 2011 Safety Expo
- January 14, 2010 - Outbreak of Human Salmonella Associated with Contact with Water Frogs
- November 6, 2009 - STONY BROOK UNIVERSITY ANSWERS THE CALL TO RECYCLE!
- July 22, 2009 - OFPC Inspections
- Feburary 6, 2009 - Peanut Containing Products Recall
- January 15, 2009 - Port Jefferson Rescue
- October 25, 2007 - MRSA Bacterial Infections
- June 6, 2007 - EPA Environmental Quality Award
- July 12, 2005 - If You See Something, Say Something
- August 30, 2004 - 3 Students Die in Frat House Fire
- December 4, 2003 - Winter Weather Safety
- August 26, 2003 - Motor Vehicle Crashes
- May 16, 2003 - University SARS Guidelines
- May 13, 2003 - Closing the Door on Lab Safety Hazards
- May 5, 2003 - North American Occupational Safety and Health Week (NAOSH)
- April 11, 2003 - Ozone-Depleting Chemicals Management
- March 13, 2003 - Habitat for Humanity Fundraiser
- January 30, 2003 - Recall of Back-Up Power Supply Systems
- January 21, 2003 - Interim final rules for select agents and toxins


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What happened to this guy? I miss the threads started by him.
Took a break I guess.
Too busy minding his own business!
Wow... This was a total disappointed.
Must be busy sitting in his lawn turning down women that want to **** his manliness and laughing at his dog messing with kids trespassing on his lawn
Oh we will fight, fight, fight for Iowa State,
and may her colors ever fly!!!
In Accordance with Prophecy
I was expecting a story...
"Winning isn't everything, it's the only thing."
Obviously nothing outrageous has happened to him lately. I mean, he doesn't seem like the type that would just make up a story. I'm sure the next time someone wears axe in his neighborhood, we'll hear about it.
James Taylor AKA nolookpass AKA nlp AKA sgtknock can be found regularly @ Hawkeyelounge.com or HROT. Usually making fun of all things Cyclone and espousing the benefits of Pleasant Hill. East Side Pride and thorough discussion of the SE Polk weight room are also common themes. His next public appearance should be @ the state fair where he works a stand. Look for a middle age man with a goatee, grey hair, muscle shirt and a small *****. Very easy to spot.
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I am proud to announce the availability of Mapping Adventures: New Expeditions! The fruits of labors from staring at an immense amount of pixels is finally ready to be shared. The online store for all things about Mapping Adventures is now online.
Mapping Adventures Online Store!!
I will be announcing details soon about the first expansion: Dungeon Explorers. I will be at PaizoCon for the weekend creating custom maps and selling this pack along with a special creature tile. It looks SO cool! Thanks for the support. Please share your comments and I will pick the best and post them on the site and reward those that I do pick with a unique tile. So unique that it will never be used in any future product. See you then!


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As General Manager Engineering and a Research Manager for Microsoft Research, Gavin Jancke built over the last 8 years and currently runs the Advanced Development Group and Web Experience Teams within the organization. He is also a member of the MSR Research Management Team that guides and runs the Redmond Lab and takes a leading role in setting engineering strategy, direction and capability for the global division.
The 35+ person multi-disciplinary Advanced Development team develops software & hardware technologies and components based on Microsoft Research innovations, from technical transfer to the main Microsoft product groups, large scale prototyping and deployment, to internal lab engineering needs. Since the team was created over 250 engineering projects have been fulfilled.
Recently he managed and led the engineering effort for the Kinect for Windows SDK Beta which was honored as one of the "10 Most Innovative Tech Products of 2011" at the 2011 Popular Mechanics Breakthrough Awards.
In his spare time he still engineers code and of late developed a new color barcode format that has a high density storage capability. This evolved into a new Microsoft product & business called Microsoft Tag which Jancke envisioned with a marketeer from the Consumer Marketing Group, secured VP funding, architected, led & managed the development and rollout of the product which launched at the Consumer Electronic Show 2009. Since the launch Microsoft Tag is rapidly gaining traction being used by major corporations & media companies and has surpassed 2 billion impressions. Over 20m Tags could be found in May 2010 issues of various major magazine publications, several Tags appear daily in every print issue of the USA Today national newspaper. The barcode format was exhibited in the New York Museum Of Modern Art Design and Elastic Mind exhibition in 2008 - see Microsoft Researchers at Intersection of Science and Art
Prior to his latest position he worked in the Chairman's Office as part of Bill Gates' technical advisory staff working on a variety of research projects in the fields of Search and Telephony which have eventually become integrated into products such as MSN Desktop Search. Before this Jancke was a research engineer in Microsoft Research's Collaboration and Multimedia team engineering a variety of projects from peripheral awareness interfaces which became the Windows Vista Sidebar, to collaboration software evolving into Microsoft Roundtable.
Prior to Microsoft Research, Jancke was Development Lead in Microsoft's SQL Server product for 8 years, spanning several versions of the product from V4.2 through V7.0. Here he lead the engineering for the graphical administration and query tools for the product line.
Jancke first started Microsoft in the UK subsidary on a 1 year university industry placement program when he was 19 years of age working in Product Support Services supporting the Windows Software Development Kit and OS/2 Presentation Manager Development Kit. From then he worked off and on within Microsoft as an intern working in the SQL Server team which he subsequently joined in full time employment, and a contractor until finally moving out to the United States.
Personal Research Projects
- High Capacity Color Barcode
- Press release: International Organization Licenses Microsoft's New Multicolor Barcode Technology For Identifying Audiovisual Works
- Seattle PI: Software Notebook: Color is key to Microsoft's next generation barcode
- CNET News: Microsoft gives bar codes a splash of color
- IT Jungle: Microsoft Breaks the Color Barrier for Barcode
- Dr Dobbs: Color Bar Codes: More Than Just a Pretty Face
- Biometric ID Card Technology
- Enhanced Telephony
- Stuff I've Seen
- Sideshow: Peripheral awareness software
- Telepresence, Tele-Meetings, and Connected Spaces
- TELEP: Tele-Meetings
- Presenting to Local and Remote Audiences: Design & Use of the TELEP System (CHI2000)
- Silent Partners: Microsoft Research featured article on TELEP
- Video Windows/Virtual Kitchen
- Linking Social Spaces: Technical and Social Issues (CHI2001)
- Fancy Meeting You Here: Microsoft Research feature article on Virtual Kitchen
- TELEP: Tele-Meetings
US Patents
- 7,751,585 - System And Method For Encoding High Density Geometric Symbol Set
- 7,676,066 - System And Method For Selectively Encoding A Symbol Code In A Color Space.
- 7,697,506 - System And Method For Enhanced Computer Telephony Integration And Interaction.
- 5,701,137 - Method for separating a hierarchical tree control into one or more hierarchical tree controls in a graphical user interface.
- 5,764,913 - Computer network status monitoring system.
- 5,917,499 - Interactive graph display system.
- 7,043,572 - Method and System for Providing a Peripheral Service to a Host Computing Device.
- 7,162,473 - Method and system for usage analyzer that determines user accessed sources, indexes data subsets, and associated metadata, processing implicit queries based on potential interest to users.
- 7,185,290 - User interface for a system and process for providing dynamic communication access and information awareness in an interactive peripheral display.
European Patents
- 05105314.8 - System and method for encoding high density geometric symbol
- Pablo Sala and Gavin Jancke, Robust Segmentation, Registration, and Decoding of Tri-2D High Density Color Barcode, no. MSR-TR-2006-119, September 2006.
- Susan Dumais, Edward Cutrell, JJ Cadiz, Gavin Jancke, Raman Sarin, and Daniel C. Robbins, Stuff I've seen: a system for personal information retrieval and re-use, in SIGIR '03: Proceedings of the 26th annual international ACM SIGIR conference on Research and development in informaion retrieval, ACM Press, New York, NY, USA, January 2003.
- JJ Cadiz, Gina D. Venolia, Gavin Jancke, and Anoop Gupta, Designing and Deploying an Information Awareness Interface, no. MSR-TR-2002-87, August 2002.
- J. J. Cadiz, Gina Venolia, Gavin Jancke, and Anoop Gupta, Designing and deploying an information awareness interface, in CSCW '02: Proceedings of the 2002 ACM conference on Computer supported cooperative work, ACM, New York, NY, USA, 2002.
- JJ Cadiz, Anoop Gupta, Gavin Jancke, and Gina Danielle Venolia, Sideshow: Providing Peripheral Awareness of Important Information, no. MSR-TR-2001-83, September 2001.
- Gavin Jancke, Gina Danielle Venolia, Jonathan Grudin, J. J. Cadiz, and Anoop Gupta, Linking public spaces: technical and social issues, in CHI '01: Proceedings of the SIGCHI conference on Human factors in computing systems, ACM, New York, NY, USA, 2001.
- JJ Cadiz, Jonathan Grudin, Anoop Gupta, Gavin Jancke, and Gina Danielle Venolia, Linking Public Spaces: Technical and Social Issues, no. MSR-TR-2000-93, September 2000.
- Anand Balachandran, JJ Cadiz, Jonathan Grudin, Anoop Gupta, Gavin Jancke, and Elizabeth Sanocki, Distance Learning Through Distributed Collaborative Video Viewing, no. MSR-TR-2000-42, May 2000.
- Jonathan Grudin, Anoop Gupta, and Gavin Jancke, Presenting to Local and Remote Audiences: Design and Use of the TELEP System, no. MSR-TR-99-71, September 1999.
Patents Pending
- Enhanced Telephony Computer User Interface Allowing User Interaction and Control of a Telephone using a Personal Computer
- Method and System for Providing a Peripheral Service to a Host Computing Device
- System and Methods for Personal Ubiquitous Information Retrieval and Reuse
- A System and Process for Dynamic Communication Access and Information Awareness in an Interactive Peripheral Display


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Theres more fun watching a ghost movie than reading a scary book. But Annie Zaidis novel, Gulab, ticks all the right boxes for an entertaining read. To start with, the book is all of 184 pages, it is a love story, it has a ghost, it has intrigue and a twist in the tale.
One summer day, Nikunj arrives in an unknown city to attend long-lost love Sairas funeral after receiving an anonymous telegram summoning him to the graveyard. But just as Saira was not to be found after a powerful earthquake years ago, her grave also eludes Nikunj.
However, in his search for the grave, he encounters two other men who have come to pay respects to their respective wives.
All three of them zero in on the same grave, claiming it to be the one. Arguments and fisticuffs later, the mystery is still unresolved. A mysterious woman claiming to be Sairas friend also arrives and the arguments escalate. In places, things actually get funny.
As they go to one mans house for proof that the grave dweller is, indeed, his wife, Nikunj realises in horror that the woman both other men are claiming to be their wives is none other than Saira.
But ones wife died years ago, while the second mans wife died just a day back. All three men are hopelessly in love with Saira, or the illusion of her. In another twist, Nikunj discovers lookalikes of his children in one mans kids.
What is happening? When did Saira actually die? Is any man really her husband? Who is the mysterious friend who claims to know Saira well?
As we get answers to all these questions as the book progresses to a finish, Zaidi delivers another punch with an unexpected ending. A book to be read in one go!


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What you're getting yourself into: 2100 words (6-8 minutes read time, plus 3 video tutorials)
Key Points Ahead:
- The muscle-up is really just the combination of 4 skills.
- There are 3 main exercises you should work on to strengthen your body for the muscle-up.
- I'll give you my programming recommendations for training the muscle-up, including a sample 3-day training schedule.
It's a move that demonstrates overall body strength and coordination that even very fit people have a hard time performing the first time they try it. But that doesn't mean it's out of your reach if you train right.
Most of the problems people have with this skill involve improper form and lack of strength in the right places. In this tutorial, I'll show you everything you need to know, from the correct grip to the important details of proper technique, and even the best way to organize your workout.
Follow these instructions, complete with videos and pictures, and you'll gain the strength and form for that perfect muscle-up.
- The muscle-up in 4 simple steps
- Specific exercises to build strength for the muscle-up
- Programming for muscle-up success
Part One: A Step-by-Step Guide to the Muscle-Up
When you see the muscle-up done as one smooth movement, it may seem intimidating or out of reach.
In reality, though, it's a simple combination of a few separate movements, each of which can be improved and strengthened. Put them together and – voilà! – you've got the muscle-up. Let's take a look at each part of the muscle-up.
Muscle-Up Step 1 – The False Grip
The correct start to a proper muscle-up begins with the grip.
Unless you are using momentum – in other words, swinging your legs and kipping up – you'll need to use a false grip. This particular method of gripping allows your hands to come over the top of the rings after you pull yourself up.
In a normal grip the rings are more in your fingers rather than your wrists, and you won't have a "shelf" to push off from, the false grip makes that happen.
This video shows three fundamental rings grips. Since we're only concerned with the false grip for the muscle-up, you can skip to 2:17 for an explanation of the grip:
In the false grip, as demonstrated in the video, the rings are set in the hand nearer to the crease of the wrist. This is definitely an awkward position for most people at first, and it takes some time and practice to get the technique down, and to figure out the tweaks in positioning that are best for you.
It also takes time to build up the wrist, forearm, and hand strength to maintain this position as you pull your whole body up and over your hands.
(Learning to grip the rings is rough on your hands, so check our hand-care tips for ring training.)
Muscle-Up Step 2 – The Pull
Once you've got your false grip technique squared away, the next step is pulling your body up as strongly and smoothly as possible. This means having a good proficiency in pull-ups.
(If you need stronger pull-ups, this article will help you out.)
A strong pull is key to a good muscle-up, and without it, you'll be unable to do one without swinging and kipping.
In your pull-up, maintain the false grip and keep your elbows close to your sides throughout the movement. You may choose to have the elbows out as you get stronger since this will make the exercise more difficult, but can make the transition to the top position smoother.
Start with your feet slightly in front of you, then pull hard and think of getting your chest to the rings and hands to your armpits. I like to say that muscle-ups are just like you're "putting on a shirt."
Muscle-Up Step 3 – The Transition
For the transition, keep yourself tight at the top of the pull and get your shoulders above your hands. That means you'll have to do a strong pull as high as possible, then lean forward at the top to get into the right position.
The position you'll end up in is essentially the bottom of a dip.
(It's essential here that your shoulders and chest are ready for this stretched and loaded position, so if you have flexibility issues, go here and get to work! You don't want to hurt yourself in training. Remember, we train to improve, not get injured!)
Again, keep your elbows close in to your sides, then lift your chest up as you prepare to push up to the top position.
Muscle-Up Step 4 – The Push
At this point after a successful transition, you've gotten through the most difficult part of the skill, which is the coordination between a strong pull and this push.
From the bottom dip position, keep an upright posture and visualize your body moving as a solid unit as you push up to the top position, rolling your thumbs outward and locking your elbows out at the top.
Part Two: The Best Exercises for Muscle-Up Strength
As you've read above, the muscle-up is broken down into the grip, the pull, the transition, and the push. So it's important to include strength and conditioning exercises that aid directly into those particular skills and moves.
False Grip Pull-Ups
This straightforward exercise is just as it sounds.
To master the false grip muscle-up, you'll want to train strong pulls in the false grip position. It'd be hard to get more specific than false grip pull-ups to train that skill!
You can work this with three different hand orientations, pulling yourself as high as possible with each:
- Hands facing toward you
- Hands facing each other
- Hands facing away from you
These different hand positions can be practiced in separate sets on the same day, or by alternating hand positions with each set. Play with it and see what works for you.
Eventually, you'll want to move to a pull variation where you start with palms facing you then rotate them away as you pull up to the rings. This mimics the motion of the muscle-up.
The Baby Muscle-Up
The transition point can be a difficult position to simulate, because it's a dynamic point that can change depending upon your pull and the particular body positioning you end up with at the top.
For this reason the best practice is to actually perform the movement itself, and this can be quite tricky. This is where the baby muscle-up comes in.
With the baby muscle-up, you'll assist yourself by keeping your feet on the floor so that you can do a lot of repetitions of the important transition point movement. Lower your rings so that you can be in the bottom of the dip position with your knees bent and feet touching the floor.
In this video I'll show you how to perform the baby muscle-up on a bar, but the same principles apply to the rings:
Practice the baby muscle-up, paying particular attention to your body positioning right before and after the transition, and make it as consistent and smooth as possible. Lots of repetitions in practice will pay off once you get your feet off the ground.
The baby muscle-up is a combination of strength and technique practice, and is quite a gem for getting to a successful muscle-up.
Ring Dips with a Pause
Another simple, but not easy, exercise that will help strengthen your muscle-up is performing dips with a pause in the bottom position, going as deeply as possible without risk of hurting yourself.
This is the exact position before the push to the top position in the muscle-up, and you can directly improve the specific strength needed for that skill by adding this into your routine.
Again, be sure you have the necessary flexibility and tolerance for this position before attempting this exercise. You'll be on the fast path to injury if you ignore pain and stiffness.
You can practice these with full body weight resistance, and also with your feet still on the ground to decrease load. Work on gradually increasing weightbearing through your arms until you can pick your feet up off the floor for the whole time.
Part Three: Exercise Programming for the Muscle-Up
You'll want to have a consistent regimen of strength and skill training in order to achieve a successful muscle-up.
I recommend at least two days a week of strengthening exercise and at least three days a week of the baby muscle-up, with an emphasis on treating the baby muscle up as a learning session rather than a distinct strength exercise.
Treating these moves as skills, you should be fresh and ready for practicing as perfect technique as you can muster. As such, I recommend more sets of less repetitions, rather than going to fatigue in higher reps and compromising form.
It's also important to vary your speeds in the pulls and baby muscle-ups. Faster speeds can get you to that transition point a bit more easily, and the slower speed gives you an idea of your weak points in the range. Both are important for improving your skill in the muscle-up.
Example 3-Day Routine:
Note well that the following is a strength / skill routine – NOT a gymnastics training program.
Gymnastics is a great sport that builds incredible ability, but gymnastic-style training isn't always the most efficient method for fitness-oriented strength training. This sample routine is designed for the average fitness enthusiast who wants to get strong and develop their muscle-up technique.
Day 1
- False Grip Pull-Ups (8 sets of 3 at a slow speed)
- Dips with a Pause (6 sets of 4)
- Baby Muscle-Up (5 sets of 5 at a slow speed)
Day 2
- False Grip Pull-Ups with hands facing each other (8 sets of 3 at a faster speed)
- Dips with a Pause (5 sets of 5)
- Baby Muscle-Up (8 sets of 3 at a faster speed)
Day 3
- Rest on strength exercises as needed.
- Baby Muscle-Up (8 sets of 3 at a slow speed)
There are many ways to set up a program to help you work toward the muscle up, but this sample program is a great place to start if the muscle-up is one of your goals.
Putting it All Together from the Bottom Up
When you're ready to put everything together and start training for the full muscle up, you'll want to start by going through some important progressions.
In this video, I'll take you through a series of muscle up variations that build on one another:
The muscle-up on the rings can be a surprisingly difficult maneuver to otherwise strong and fit trainees.
It's a unique combination of strength and coordination that requires not just repetitive practice, but correct practice of the right things and good attention to the details of proper technique.
With the right approach, technique, and dedicated practice, the muscle-up is an accessible move for most people. The most important thing is to build a solid foundation of skills and strength, and you'll get there with time.
My Recommended Gymnastic Rings
We get a ton of questions about which rings are the best, and honestly, there are a lot of great options out there now that didn't exist just a couple of years ago.
If you're just starting out, you can get by with a cheap set off Amazon.com, but we prefer using the wooden gymnastic rings from Rogue Fitness. They are comfortable to grip, easy to adjust, and are built right for safe and dependable use – I've been using mine almost daily or over two years now.
Build Your Strength Systematically
The rings challenge your body in ways that can't really be replicated with other training tools, and there's a steep learning curve for getting comfortable with how to safely engage the body to perform basics – and especially more advanced skills like front and back levers.
We recommend using a systematic and patient approach like we teach in our Rings One program to gain mastery over your body and build upper body and core strength with the rings.
Rings One: Our Introduction to Gymnastic Ring Training
Learn all the basics of safe and effective ring training while developing your strength for perfect, strict muscle-ups and other combination moves:
Whether you're ready to pump out muscle-ups or still new to this type of training, working with the rings is challenging.
But if you work at it consistently, the results are worth it.


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Melia Albrecht's studies have taken her to South Korea, Egypt and Turkey, but Lanterman High School, just a few blocks from campus, is the place that really stands out to the USC Dornsife junior.
That's where Albrecht volunteers with Best Buddies, an organization that fosters one-on-one relationships with people who have intellectual and development disabilities.
"Best Buddies is my favorite," said Albrecht, a double major in international relations at USC Dornsife and public relations at the USC Annenberg School for Communication and Journalism. "I think it's important that you have one organization you do just for fun — one that you do because it makes you happy."
That's just one of the many activities on this Trustee Scholar's résumé, along with the USC Helenes, USC Dornsife Ambassadors, Council on International Education Exchange (CIEE) scholarship program and Marshall's Women's Leadership Board.
"Exploring and talking to people is the best way to learn," Albrecht said. "This is probably one of the best chances you are ever going to have in your life — to be surrounded by so many brilliant people who are all doing something different."
Melia Albrecht is double majoring in international relations and public relations, while also completing an honors multimedia program. Photo by Madisen Keavy.
German-born Albrecht is also completing an honors multimedia program. And last semester, she spent her spring break traveling to South Korea as one of 40 university students from around the country chosen by the CIEE.
"I spent 10 days in Seoul with a host family eating the food, meeting different people and seeing new things," she said.
Her favorite part of the experience came when she visited the demilitarized zone, which sparked the flame to continue her travels to unlikely international destinations like Egypt.
Thanks to a USC Dornsife Summer Undergraduate Research Fund (SURF) grant, she was able to do just that. She traveled to Egypt and Turkey where she met and interviewed international leaders. With a dream of someday working for National Geographic, it's no surprise that Albrecht's favorite interview was with the editor-in-chief of CNN Turkey.
Albrecht shows no signs of slowing down. An undergraduate scholar this year with USC Dornsife's Levan Institute for Humanities and Ethics, she also has internships with the Los Angeles World Affairs Council and Annenberg's "Journeys In Film" program.
But she always makes time for Best Buddies.
"Melia truly cares about each person she meets and this is easily seen through her relationship with her friend she met through Best Buddies, Norma," said Albrecht's friend and fellow USC Dornsife undergraduate, Melina Sutton. "She could be speaking at a conference about international relations or traveling the world, but she never forgets the people who have made an impact on her life."


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If you're Serious about Investing in...
The World Vaccines Market Is Predicted...
Researchers Are Developing Ways to Edit...
Traditional Tissue Biopsies Are Not Providing...
BioFocus, the service division of Galapagos, has entered a three-year collaboration with Biogen Idec where it will use its SilenceSelect® platform and human skin models to deliver new assays and identify validated, disease-modifying targets in scleroderma to the biotech firm.
BioFocus will receive an up-front payment, FTE funding, and will be eligible to receive success payments for the target discovery milestones it delivers, and also for development milestones achieved by Biogen Idec. The firms say the total value of this collaboration could reach $31 million.
"We believe Galapagos has unique expertise with relevant human primary cells, positioning them well to find new targets for disease-modifying therapies against scleroderma," said Jo Viney, vp of discovery sciences at Biogen Idec.
According to BioFocus, its SilenceSelect collection consists of up to 17,000 shRNAs that can be used to knock down over 5,000 different human druggable targets. These 5,000 genes, the firm says, represent more than 11,000 transcript variants.
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Chemical: Drug
denileukin diftitox
PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB annotates drug labels containing pharmacogenetic information approved by the US Food and Drug Administration (FDA), European Medicines Agency (EMA), the Pharmaceuticals and Medical Devices Agency, Japan (PMDA), and Health Canada (Santé Canada) (HCSC). PharmGKB annotations provide a brief summary of the PGx in the label, an excerpt from the label and a downloadable highlighted label PDF file. A list of genes and phenotypes found within the label is mapped to label section headers and listed at the end of each annotation. PharmGKB also attempts to interpret the level of action implied in each label with the "PGx Level" tag.
See the legend for more information about drug label sources and PGx Levels.
We welcome any information regarding drug labels containing PGx information approved by the FDA, EMA, PMDA, HCSC or other Medicine Agencies around the world - please contact feedback.
1. FDA Label for denileukin diftitox and IL2RA
The FDA-approved drug label for denileukin diftitox (Ontak) notes that it is indicated for patients with persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the IL-2 receptor. Confirmation of malignant cells expressing CD25 is necessary prior to administration of the drug.
Denileukin diftitox (Ontak) is indicated for patients with persistent or recurrent cutaneous T-cell lymphoma. The FDA-approved drug label for denileukin diftitox states that confirmation that a patient's malignant cells express CD25 is necessary prior to beginning treatment with the drug.
Excerpts from the denileukin diftitox (Ontak) label:
Ontak is a CD25-directed cytotoxin indicated for the treatment of patients with persistent or recurrent cutaneous T-cell lymphoma whose malignant cells express the CD25 component of the IL-2 receptor.
CD25 Tumor Expression and Evaluation...Confirm that the patient's malignant cells express CD25 prior to administration of Ontak. A testing service for the assay of CD25 expression in tumor biopsy samples is available.
For the complete drug label text with sections containing pharmacogenetic information highlighted, see the denileukin diftitox drug label.
*Disclaimer: The contents of this page have not been endorsed by the FDA and are the sole responsibility of PharmGKB.
Genes and/or phenotypes found in this label
- efficacy, Indications & usage section, Description section, Clinical pharmacology section, Warnings and precautions section
- source: U.S. Food and Drug Administration
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
- Diphtheria toxin precursor
- NAD(+--diphthamide ADP- ribosyltransferase)
- denileukin diftitox
- Ontak
- Ontak (Seragen Inc)
PharmGKB Accession Id
A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.
Source: Drug Bank
Other Vocabularies
- ATC: Other antineoplastic agents (L01XX)
- UMLS: denileukin diftitox (C0717670)
- RxNorm: denileukin diftitox (214470)
Information pulled from DrugBank has not been reviewed by PharmGKB.
Pharmacology, Interactions, and Contraindications
Mechanism of Action
Denileukin diftitox binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells.
Source: Drug Bank
Denileukin diftitox (Ontak) directs the cytocidal action of diphtheria toxin to cells which express the IL-2 receptor. The human IL-2 receptor exists in three forms, low (CD25), intermediate (CD122/CD132) and high (CD25/CD122/CD132) affinity. Malignant cells expressing one or more of the subunits of the IL-2 receptor are found in certain leukemias and lymphomas including cutaneous T-cell lymphoma (CTCL). Ontak interacts with the high affinity IL-2 receptor on the cell surface and inhibits cellular protein synthesis, resulting in cell death within hours.
Source: Drug Bank
Absorption, Distribution, Metabolism, Elimination & Toxicity
- 0.6 - 2.0 mL/min/kg Lymphoma
Source: Drug Bank
Chemical Properties
- UniProtKB:
- National Drug Code Directory:
- 62856-603-01
- DrugBank:
- Therapeutic Targets Database:
- FDA Drug Label at DailyMed:
- 42dfffb1-d0f3-42d5-944c-64f092fc436e
Clinical Trials
These are trials that mention denileukin diftitox and are related to either pharmacogenetics or pharmacogenomics.


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Oslo Conference: Landmines banned
17-09-1997 News Release 97/25
Geneva (ICRC) - The International Committee of the Red Cross (ICRC) and the International Federation of Red Cross and Red Crescent Societies wholeheartedly welcome and endorse the new treaty of international humanitarian law forever banning anti-personnel mines, which was concluded earlier today at a Diplomatic Conference in Oslo. " This is a victory for humanity. It shows that it is possible, with determination and perseverance, to make significant improvements in international humanitarian law " , said Louise Doswald-Beck, head of the ICRC delegation to the Conference.
The treaty contains an unambiguous prohibition on the use, production, stockpiling and transfer of anti-personnel mines. It requires the destruction of stockpiled mines within four years and of mines in the ground within ten years.
Since the lCRC launched its appeal for a total ban on anti-personnel mines in February 1994, the entire International Red Cross and Red Crescent Movement has worked strenuously to raise public awareness of the problem and to encourage diplomatic and military circles to strive for this historic breakthrough. " The Red Cross and Red Crescent Movement will do its utmost to achieve universal ratification of the treaty and to ensure its earliest possible entry into force so as to end once and for all the horrendous suffering caused by anti-personnel mines, " added Louise Doswald-Beck.
The treaty will be formally adopted by the Oslo Diplomatic Conference on Thursday and opened for signature in Ottawa, Canada, on 3-4 December. The vast majority of the 106 States that officially launched the process in Brussels in June 1997 are expected to sign the treaty, whic h will enter into force once 40 signatory States have ratified it. In the meantime, States are nonetheless expected to respect the core obligations it lays down.