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I am 40.5 and was recently tested with high FSH. I have secondary infertility. I am seeing a RE(Susan Willman), OB(Kurt Wharton) and an acupuncturist. My husband also has sperm issues. We are considering an unmedicated IUI for the first cycle since I like to give acupuncture and herbs a try for maybe 1 to 3 cyles. Our insurance does not cover any infertility treatments. IUI at Dr.Wharton is around $300 and IUI at Dr.Willman is around $900. IVF is not an option for us due to finances and my high FSH. A couple of questions: *If I don't go on meds, does it matter who does the IUI? *Or should I be more aggressive and go on meds right away? Dr. Willman is okay with waiting on meds. Anon
Hi - I finally realized I want to have a baby at age of 42. As I was always healthy and all my tests, and my husband's, were good we took time trying to get pregnant naturally. Finally, last December we started seeing Dr Susan Willman at RSC in Orinda. We had a couple of IUIs, did Clomid challange once and concluded it was not of great help for me. I kept on believing it would happen and finally my age hit me as i turned 44 in June. I tried Femara last cycle and it didn't work so I finally asked for IVF to learn that they would not do it for me since I was too old. I have HealthNet and am now wondering if there is any other place that may consider me for IVF. Some earlier posts talk about UCSF being more accommodating? Any advice on how to get accepted for IVF somewhere would be greatly appreciated. I still believe I can get pregnant. Also, I saw Dr Angela Wu, acupuncturist, for 6 months- I enjoyed the treatments but found her practice too industrialized w/o attention to individual. Everyone was very nice and kind at her place though. Anyhow, thanks in advance for any advice you might have! -hopeful
Another thing that I found very helpful was to join RESOLVE, which is a national organization helping people deal with infertility. My husband and I took part in a couples group led by a therapist who had also experienced infertility. It was enormously helpful and cathartic to be able to talk with others who were going through the same thing. anonymous
I would like to learn from other women who may have had a similar experience. I had an easy pregnancy at age 37 with my first child. I'm now 40, and I've suffered three miscarriages in the last eight months; all pregnancies ended at about seven weeks. The most recent miscarriage was analyzed and the doctor found a chromosomal problem with the fetus. It's possible that the other two pregnancies ended for the same reason, but we don't know definitively. I am trying to decide what to do. I am willing to risk the emotional and physical toll of further miscarriages if I end up with a healthy pregnancy, but my doctor didn't have any information about the odds of this happening given my history. So I'm feeling a little lost. Has anyone else gone through something similar, and learned what the chances are for a healthy pregnancy after multiple miscarriages at this age? Are there such statistics? Is there anything I can do? The doctor mentioned donor eggs, and IVF, but I'd like to learn more about my chances before going down that route. Many thanks for any advice. anon
I did a lot of reading to try to understand what could be happening, and from what I found, the odds are actually in your favor for a successful pregnancy; I think they're even better because you have had a child. I found Jon Cohen's book ''Coming to Term'' (you can get it off of Amazon)to be really informative, a nice combo of scientific information with personal stories. He is a science writer whose wife had 4 miscarriages in a row before having their 2nd child, so he started researching and ended up writing this book. If I remember right, statistically close to 70% of women who have had 3 (may even be 4) miscarriages will eventually carry to term. Good luck. Anon
I have a lovely son that he delivered at 38 weeks via planned C- section and the support I needed from the therapist and the physician were both key for me. I can only imagine that coming new to this area will be challenging as well as a ''fresh start'' for you. Making connections to folks who can support you will help in your dreams of starting a family. Good luck and feel free to contact me.
Peace, Katy
The good news is that you are getting pregnant pretty easily and if you can take the emotional roller coaster you might have a good chance of a successful pregnancy. The other good news is that you can carry a pregnancy successfully and if you do decide at some point to go the Donor route you have a very good chance of success (it's comforting to know that your last chance plan has a high rate of success).
I can share some info I've learned along the way. If you can afford it I'd go consult with an RE as soon as possible. Once you get into your 40s time is very important. They may run some more tests (antral follicle count and FSH) and give you a better sense of statistics. Try to find someone who works with older woman - some clinics are very concerned with there statistics which are all posted on the CDC and may push you towards donor egg before you feel ready. There are a few things that some research argues helps embryo quality - in no particular order. 1. lots of antioxidants, 2. cutting out coffee and alcohol and recreational drugs (these hurts quality of the egg evidently) 3. acupuncture with someone who specializes in fertility. Since the egg is recruited 3 months before ovulation all these things are long term. If money is no issue you may want to try IVF with your own eggs or even a medicated IUI since it will increase your chances and may give you some answers.
Good luck! It's a really hard decision and unfortunately there are no easy answers. anon
Help, I really need some advise. After struggling with infertility and failed IUI's we finally took the plunge and went for IVF. All the initial tests looked great so I started taking the drugs. At 41 I knew the odds were not in my favour, I was prepared for the possibility that some embryos might not develop and that those that did might not take. What I was not prepared for was that I would only produce 2 follicles and therefore not even be able to go ahead with IVF. So now I'm trying to figure out where to go next. Unfortunately my hormones made me burst into tears every time I tried to talk to the doctor so I didn't get much info from him. Has anyone out there had a similar experience? Is there anything I can do to boost the amount of follicles I produce. The doctor said we should try again in a couple of months but there was a good chance we would have the same results. Any suggestions are appreciated.
What I learned from all of it is that the doctors cannot predict what your body will do in the future. My doctors were baffled by my last cycle and told me I could have gotten pregnant that cycle with no intervention. There is a bigger ''cycle'' that is happening in addition to your little monthly cycles. You may have several more great cycles before menopause or you might not. You might have one really great cycle next month or next year. My point is that several bad cycles indicate a problem but there is no way to fully predict future cycles unless your doctors have found a very specific, very definite problem. All the doctors at my clinic were urging me to give up and they were wrong.
But I feel your doctor is doing the right thing by preparing you for the fact that it might not happen. You should be thinking about this possibility but at the same time try to maintain some sanity. Ha! I laugh as I write this thinking back to how many times I burst into tears trying to have a conversation! There is nothing wrong with you to be feeling this way. Take very good care of yourself. As stupid as this sounds you really need to pamper yourself. Eat very good food, get lots of rest, go for walks in beautiful places, stay away from people who aren't supporting you etc. And remember that all the initial tests looked good.
Many issues come up with infertility. For me it was a huge financial drain. We ended up borrowing thousands of dollars from our family. So it also comes down to what do you want to do over the next couple of years. How do you want to spend your money and can you stand all the discomfort, both physical and emotional, that comes with fertility treatment? I was at the end of the road with my last IVF. If that failed I was not going to try again and I had reached a point where I was OK with that. Are you OK with not trying any more? If you are then maybe start exploring how to build your family in another way. Also, early on I felt so devastated but I did comes to terms with it BEFORE I got pregnant. It is a long process but you will survive this. I feel for you
I am 42 yrs old and was 14 wks pregnant when I had some very mild (what I thought)gas pains one evening, went away, came back the next morning(not painful),I went to the bathroom and my water broke. I started bleeding immediately, and had no heartbeat at the hospital and a D&E. I had just had a sonogram 3 days prior and heartbeat and measurements were fine. When I was 29 I had a fetile demise at 20 wks. (no HB at regular appt and baby had stopped growing at 17 wks)OB will not consider these 2 connected due to different fathers(I am remarried) and a baby I had in between(4 yr old boy, also 18 yr old girl and 14 yr old boy) Insurance has not covered checking baby for genetics either time and I am not sure as to whether due to my age or some other problem, I should try this again. 2 D&E's and feeling very sick with these 2 pregnancies and the sadness of the miscarriages(and felt healthy and wonderful with the other 3 pregnancies) scares me to try again. Any advice would be appreciated. l.
I've my first daughter at age 42 and I've been trying for 18 months for a 2nd child, with 1 failed IUI and 2 failed IVFs. I'm getting ready for a 3rd IVF attempt but I'm losing all faith and losing all hope that we will succeed and would like to know if anybody out there who's 44 and above and have conceived naturally or thru IVF using own eggs? I've been on acupuncture and also TCM for 3 months now but not hopeful that these would help increase the chances. I was on acupuncture and TCM during my last IVF attempt. I would appreciate anybody out there who could give me some hopeful advice. My husband and I had eliminated using donor eggs or adoption. My husband has good sperm count and motility. I'm very guilty that I'm the one responsible for not being able to grant my daughter a sibling as she loves babies and will be a good big sister. Hopeless Advanced Maternal Age Mom
She did a series of plastic surgeries on my uterous, made it a good place to grow in and set me up with the egg brokers. (my words, not hers) That was an amazing process. I could write a lot about it but, in the end, we got a lovely woman who was the same chop suey mix that I am. She had the same hands, feet, coloring, texture, and general build as me. However, she had no history of insanity or anything except the occaisional alcoholic in her background, which, in my case was trading up.
So, while I felt a lot about having to have a donar egg, I also feel a lot of relief knowing that I am the only one genetically pre-disposed to senile dementia and paranoid delusions in our little family. As a mother, there is enough powerlessness!
OK, you have one child and you want another. Why not let your husband's sperm get with a younger version of yourself in the dish? You probably have a great gene pool and it is sad... Well, so many woman have heartbreaking results with want want wanting that second child. If the gap is too big, and if the second child is medically fragile? I don't know, it is all hard.
There are so many parts of it to mesh together. How your husband feels is a big part. Infertility can rip you to shreds and people rip each other up about it sometimes. I certainly felt ''barren'' and ashamed. I was sad that I had to spend my nest egg.
My husband was awfully proud of his motility count and it was hard. ''That's nice honey!''
You know, a life saver for me was someone I met on the other side of the curtain at the fertility clinic. We saved each other a bundle calling and talking the fertility lingo... She was the only person in my world who knew what I was talking about. I guess that's where RESOLVE and other groups are so helpfull...you can flame off and get something to hold on to when you feel adrift... I'll listen off list if you need me. ad
Do what you need to, and if the next round of IVF works, mazel tov! But if not, deal with your grief and try to refocus your loving attention on your daughter and all that is great about being together. Best wishes. anon
I suspect that your stress over the situation is interfering with your plans... but its hard to be casual and carefree when you think you're time's running out. For me, the trick was giving up. Once I knew it wasn't going to happen, it happened.
Maybe it would help to remember that your daughter will be fine either way. You're the one who will have to deal with disappointment...and you will, if you have to. Good luck! Third Kid's the Charmer
I know you have this dream of having a second child and sibling for your first but it is a reality that fertility declines rapidly after age 40. You were blessed to have your first after 40. Please stop feeling guilty. You have no control over your fertility decline. Men don't have this same decline so its normal that your husband would continue to be fertile. Its no one's fault just life.
If you really want a sibling there are many options: egg donation, open adoption, public adoption...Don't get stuck in the idea that there is only 1 way. You never know, this may be an opportunity to find the child you meant to have, I know it was for us :) happiest mom
My husband and I are in our forties. We are trying and trying to have a second child. We tried chinese herb and acupuncture for about a year to no avail. We checked our bodies with an ob and found nothing wrong. Any advice, ob/gyn, therapies, acupuncturist recommendation is much appreciated. anon
If you think I'm exaggerating, let me just say that the national average live birth rates for 44-year-old women undergoing IVF with their own eggs for fresh cycles is 3.3%, but at CCRM it is 16.5%, and no other center in the country can approach that. (These are 2006 statistics, which will be published in the next couple of months on SART.ORG) Childless till CCRM
I'm very sorry that your eggs lost a critical year while you discovered that acupuncture and chinese herbs are no more effective than placebos. I don't know if a lawsuit could ever recover enough to compensate for what might have been.
On the bright side, I know foster parents who adopted lovely children who had been placed in their care. If you want a girl, there are thousands of girls in Chinese orphanages still waiting for parents. Too late smart
I am 42 with FSH 7 and have had 3 failed IUI's using frozen donor sperm. My doctor says that , though my FSH is in ''normal range''( his term) and I am making 5-7 follicles a cycle on clomid alone, egg quality may be a factor in my lack of success. I cannot afford IVF as my insurance does,'t cover any of it and I am SMC of a 4 year old. Is there anyone out their who is my age w/ similar FSH level who had success w/ IUI who didn't use fresh sperm? Am I just waisting my money? Thanks dc
I got pregant after my 9th attempt (also using Clomid with 5 -7 follicles a cycle) and I miscarried. Sad, but true.
I got pregant again after my 11th attempt. Here's what worked - you need to cover the cycle. When I knew the follicicles were ready, I used a non-washed vial at home. (Think Turkey Baster only smaller) the next morning I had an IUI. It worked. I have a beautiful daughter to show for it.
Interestingly enough when she was 2 1/2 she said to me. I've been inside you before. (she started talking at 7 months). I said ''oh really.'' Yes, she said, but the rule is you have to decide if you want to be a boy or a girl. I wanted to be a girl, not a boy, so I had to start over.
Life's good - you'll get there - keep trying. Mom of a girl who did not want to be a boy
After trying to get pregnant for a year, I was successful after taking Prometrium for 2 months. Unfortunately, I was diagnosed with a ''missed miscarriage'' at 9.5 weeks (embryo had stopped growing at 7.5 weeks) and just had a D&C. I am trying to work through the grief, but I'm pretty confident that I'd like to try again.
I am seeing Dr Huibonhoa right now, whom I like in general, but she seems overworked (she initially forgot to tell me about test results indicating insufficient Progesterone). Before I got pregnant, she suggested IVF right away since I'm 40. I would like to stay away from ART for a while since I know that I can get pregnant.
I'd love advice on what I can do to enhance my fertility, what tests I should look into to ensure I can have a viable pregnancy, and what I need to monitor during early pregnancy to ensure the next one goes well (e.g.should I work with an RE?) I'd specifically appreciate recommendations for practitioners and other concrete information. Anonymous, please
Yesterday I had my second miscarriage within 8 months. This pregnancy resulted from having sex one time after having gone off birth control. It appears that while I can get pregnant, I cannot stay pregnant due probably to old eggs and chromosome issues.
I have been reviewing articles by Jon Cohen who wrote a book about miscarriage and older women which actually seems somewhat uplifting. I would like to explore the option of ''PGD'' pre genetic diagnosing eggs to essentially weed out the bad ones. This seems like a better option than just having miscarriage after miscarriage, however at 44 it would appear that the fertility clinic cut off age is 43.
Are there no exceptions? Even if it is shown the woman can become pregnant? Is the only option donor/adoption at this point. Any advice would be so greatly appreciated.
My insurance (blue shield) said that they did not cover any fertility. But they did pick up all of the tests and blood work and of course the pregnancy & birth. Willman's fee was not as much as other women I have talked to had to pay.....
Now I have met women who did not love her. She does not emit one ray of false hope. But, if she does give you something to hold onto, you can believe it. Besides, I have 2 perfect children thanks to her. I think that she is very good. Wishing you well!
I don't know why, I don't know how, but either docs are not trained to look for this, or it is simply exquisitely difficult to see with the various imaging technologies. We've found a doctor who excels at this, and I really think you can't afford not to consult with him. Any woman who suffers multiple miscarriages of unknown etiology should raise a high index of suspicion for suptate uterus. A septum is a non-vascular portion of the uterine wall. The fetus grows until it hits the septum, at which point it is denied blood flow and must miscarry.
I feel a bit like a snake-oil salesman here; I'm never this vehement about anything. But I've seen this diagnosis missed so many times that I am awestruck. Believe me, there is a lot of quackery out there. You are incredibly vulnerable right now and willing to try anything. (I sent a vial of cryogenically frozen sperm to the animal science lab at the Univ of Nebraska, but that's another story.) The bottom line is that at your age, you don't have much time. Your docs will tell you not to be concerned until three miscarriages, but you don't have that luxury.
The doc you need is Charles March, and unfortunately he's in LA. I really wouldn't accept anyone else--they just don't yet know how to look for septums. So do yourself a favor, spend 100 bucks on a flight to LA, see Dr. March and put this to rest. It may even be possible just to FedEx him your images. But don't fart around with immunology, acupuncture, off-the-wall genetic testing and everything else out there until you are dead sure that you don't have a septum. And PLEASE PLEASE PLEASE don't ''just try it again and see what happens'' like your docs probably want you to. If you have a septum, your baby will miscarry. End of story. Sorry to be so blunt. I know this is a miserable thing to be going through. But time is of the essence and you can't afford not to know for sure. Dr Charles March is at 310-828-3310 310-828-4008 If you have any questions, please don't hesitate to email me. Best of luck. Don't give up. zac
Hi, I am 41, have a beautiful boy who is nearly three, and have been trying to conceive again for about 1.5 years. I had some tests that confirmed that my FSH is about 14, which is of course high. We also know that my husband's sperm is not great, high count but low mobility (it was the same when we conceived our 1st baby, however). I am doing accupuncture to enhance fertility, and soon may do a cycle of ovarian stimulation w. FSH plus artificial insemmination. Basically, what I hear from the doctors is that a pregnancy for us is a long shot, which makes me extremely sad. I am beginning to have a very hard time staying hopeful, even though I feel that hope is important to help us conceive. Additionally, my over-40 friends who have been trying to conceive all are pregnant now--but not me. It hurts.
Does anyone have any hopeful stories of conceiving after 40 with a high FSH? Or any words of wisdom, or spiritual practices that helped with attitude? I sure would be grateful for the help. Thank you! Trying to hope for a miracle
If you are seriously attached to having another child that is genetically yours, I would highly recommend foregoing IUI (artificial insemination) and go straight to IVF wth ICSI (where they inject the sperm right into the egg). The odds of IUI working are not good in your situation, especially in consideration of your male factor issues. I would be afraid that after several tries you'll find you've spent as much money as you would have on IVF and wasted 6 months.
In the meantime there are some homespun things you and your husband can do to improve the situation....
YOU Give up sugars and carbs and eat protein and green vegetables. Follow something like the Atkins diet. (after 3 years of trying this is what finally worked for me). Relax and stay stress free (ha ha!)
HUSBAND Tons of Vitamin C and L-Arginine. No cigarettes, alcohol and ESPECIALLY NO POT (this has totally ill effects on motility) for 3 months prior to trying (sperm life cycle 90 days).
Sending you best thoughts and apologies if this message seems abrupt, vague in places and does not offer much spiritual advice. anon
My husband also has male factor issues (normal volume and count, but low motility and morphology). We conceived our first child spontaneously despite being told that we would not be able to conceive without IVF/ICSI due to the male factor issues. We very much wanted to avoid IVF/ICSI for our second child, so we had been trying almost everything else possible for the past 28 months. We tried varicolcelectomy and Proxeed for my husband (didn't help), and 5 cycles of Clomid with IUI. Nothing worked. In retrospect, I wish my Reproductive Endocrinologist had been more forthright with me. The sad truth is If you're 40 or over, particularly if you have male factor issues, you're wasting valuable time by trying anything other IVF with ICSI. Also, high FSH gives you another unfortunate twist. Many IVF clinics will discourage you from even trying IVF unless your FSH is 10 or less. You will be given the ''your chances with your own eggs is less than 1%, why don't you try donor eggs'' speech.
All that being said, it is not impossible, but it is difficult to conceive with your own eggs at 40+ with high FSH. You should, however, do your research and go into this with your eyes open. Here are my suggestions
1. Ask yourself how much you really want a second child and if the second child must be your biological child. You'll find that infertility takes over your life, and it's good to be really clear on what you're doing before embarking. You'll be told over and over again that your chances of conceiving will be much better if you use donor eggs, but that is a big step to take emotionally. You may also wish to consider adoption. While considering these options, it's probably a good idea to seek out counseling. RESOLVE has the names of therapists who specialize in infertility issues and can help you work through the whole biological child v. donor egg vs. adoption issue.
2. Ask yourself how much time and money you want to invest in the process of having a second child. We ended up spending 2+ years, and many, many thousands of dollars, even though we are fortunate enough to have infertility insurance. We had to take out a 2nd mortgage on our home to finance our costs. I also ended up quitting my job because the infertility journey was taking so much time and energy.
3. Get support and info. There is a ''Women over 40 with high FSH'' support board at www.network54.com/Forum/53068 that is an excellent source of info. Other websites I've found useful are ivfconnections.com and fertileheart.com. There's an excellent list of books at the ivfconnections.com website that you might want to check out. In particular, read Julia Indichova's book ''Inconceivable'' about a woman who conceived naturally at the age of 44 with FSH of 42. Fertileheart.com is her website.
4. If you decide you want to pursue treatment with your own eggs, find yourself an EXCELLENT Reproductive Endocrinologist (i.e., a fertility expert). Do not waste your time with Gyns. Also, you need to find yourself the RIGHT RE. Most REs will tell you that they do not recommend treatment at your age and with your FSH. I would do as much research about high FSH/REs as possible. The high FSH support board is a good place to start. Locally, I would stay away from any RE/clinic other than Dr. Christo Zouves at Zouves Fertility Center in Daly City (www.goivf.com) or possibly Dr. Miliki at Stanford. The top REs nationally for high FSH are Dr. Sher at SIRM in Las Vegas and Dr. Jerome Check at Cooper Institute in Marlton, New Jersey. They have very different approaches and are each quite controversial. Each has a pretty good success rate with women with high FSH, however.
5. If you want to try with your own eggs, I highly recommend Traditional Chinese Medicine as an alternative therapy. The big ticket item around here is Dr. Angela Wu on Clement Street in S.F. (www.wushealingcenter.com). Her practice is devoted to fertiliy issues and she has a lot of success with older/high FSH women. She is, however, VERY expensive - expect to pay $200+ per treatment, including herbs. Also, it takes a lot of time and energy to trek out to the outer Richmond once or twice per week. Again, you need to decide upfront how much time, money and energy you want to put into this. I've also heard and read excellent things about Dr. Y.C. Chiang in El Cerrito. Other local acupuncturists who treat infertility are Leslie Oldershaw in Piedmont and Nancy Rakela and Marty Lee Kennedy in Berkeley. Also check out www.easternharmony.com. There's an excellent article about maternal age and egg quality there with TCM suggestions on improving egg quality.
6. Don't overlook the male factor issue. Many REs believe that the best way for older women with high FSH to conceive is naturally. The only urologist around here worth much in terms of infertility is Dr. Paul Turek at UCSF. There might be something that can be done about your husband's condition.
7. If you really want a child, believe that you will get the child that is meant for you, whether the child comes to you from your own eggs, through donor eggs or adoption.
Best of luck to you! Been there
Sometimes I wonder if I stopped stressing out that month. (''Probably won't work but we might as well have fun!'') Maybe that helped. Who knows. Probably just a fluke. But if you can try not to worry too much... I know that's hard to do.
That being said, I had also started to think about adoption or invitro. Good luck! FSH is just a number
I am looking for a fertility specialist in the Berkeley area. I have searched the UCB Parents archives and found the information there to be from 1998 and 1999. I am forty one years old with two kids eleven and sixteen. I really want another baby. However I do not feel that I need in vitro or artificial insemination. I am just interested in drug therapy. Any advice or recommendations would be good. Alexandra
We are considering having a third child - our first two are in middle school and high school. I would really like to have a baby but my husband is 10 years older than I am, feels he is too old, and also feels it would put a financial strain on the family. I would like to hear from other parents who had a baby after 40 - how did it work out for you?
Finances are usually a concern. You need to ask yourselves how much you and your husband really want to do this, is it somewhat realistic or would it cause severe hardship and whether you can reach an agreement which works for both of you. We have no regrets and while my husband isn't particularly verbal, I know that despite his initial misgivings, this child has enriched his life immeasurably and he is truly grateful for him. Good luck!
There are a couple of good resources on the web for people interested in fertility issues and over-40 pregnancies: Low-tech Ways to Conceive (FAQ from various newsgroups) -LONG- Pregnancy After 40: email discussions on ParentsPlace.com
We ended up joining a Resolve support group which was terrific. In the group of 6 couples, 4 over 40, 2 of the over 40 year olds did get pregnant and give birth to healthy children. Both of the under 40 year olds did likewise. The rest of us adopted. IVF was used for all but one of the pregnancies. For both women over 40 who gave birth, donor eggs were used. Obviously this is just anecdotal info but I thought you might be interested. If you go the IVF route, be sure to get info from the program you choose not merely on number of pregnancies they have also on number of babies carried to term.
My first and only child was born at age 39 and quite frankly I should have attempted pregnancy earlier, "if " I had been serious. Of course I wasn't "ready" at an earlier age and am very pleased with my decision.
Our clocks are all different and my periods became "very iffy" by 42. There is some thinking that heredity (our mothers) has something to do with this. I am very grateful for my only child and all that I can give simply because I am an "older" Mom.
We know that there are wonderful success stories out there . . . and some not so wonderful stories. All things in life really have a strange way of working out exactly the way they are supposed to" with or without medical intervention". I wish you the best of luck and success in whatever decision and choices you make.
The most helpful thing was when I figured out when I ovulated, by charting my temperature before rising each AM, then started timing sex for my fertile days.
When I first started trying to get pregnant at 35, my doctor became concerned and started me and my husband on some tests. Several of my friends were trying for the first time in their thirties, and not getting pregnant either. First, it just takes longer at that age. Second, our own concerns, our doctors' concerns, and all the publicity about biological clocks, made us incredibly anxious. Unfortunately, tension and anxiety sometimes interfere with getting pregnant.
It's likely to help, and it won't hurt, if you cut down on your stresses and do relaxing things. I got pregnant the first time after finally getting a pet cat, as I had been wanting to do for a while. Coincidence? Maybe. Or maybe not. Other people advise taking a relaxing vacation. Good luck.
We tried 3 cycles of it with no luck and were told to use donor eggs. The last cycle I used 6 amps of metrodin (same as pergonal) each day for 10 days. That was $3000 for those drugs alone, but we were lucky that our insurance covered it.
We went for a 2nd opinion at UCSF (I was going to Chetkowski in Berkeley) Dr. Schriock looked at my FSH test levels from day 2 of my cycle and said given my results, he never would have done a cycle. My odds of producing eggs were low, odds that one would implant lower, odds of miscarriage were growing and odds of deformities growing.
Sorry for such lousy news. All I would suggest is you go to a specialist from the start and have them explain all the test results right off. The reason we kept trying was because we are blessed with a healthy son that they didn't think we would conceive AND insurance paid for most everything.
You can definitely put mine on the Success side. I was 45. My first and at that time, only, daughter was 21 - years, not months, and on her own. I got pregnant on an "oops." I'm sure the fact that I wanted very much to have another child was helpful. My now 7-yr-old daughter was born with both my daughter and my husband's grown daughter as birth coaches in the L & D room. Tama scored 9 1/2 on her Apgar and is a normal, "spirited" child who is the light of my life.
Our story became something of a legend among a group of (a little younger) friends who had been trying to get pregnant. And most or all of them did end up conceiving. So don't feel like it's hopeless, sisters. We're living proof that it's not.
And I'd like to say that even though adoption is long, tedious and expensive, I feel certain that a child is a child, and an adopted child is every bit as much "your" child as a birth child, and you will become just as attached and just as in love, even though she doesn't come through your body.
By the way, my older daughter has her own daughter, age 4. The two girls are the best of friends and mine takes her "aunt" role very seriously. We think of ourselves as heavily invested in kids over here, and the truth is, kids of all ages are right up there in my list of the top 5 things of life.
I would love to hear from other older moms of 6-8 yr olds. I find myself so much more patient and skilled at parenting this time around, even though this child is so-o-o much more challenging than the first one.
P.S. I spent the Fourth w/friends and met a woman who had her first, a boy, at 43, after trying for years and finally adopting a precious little girl. She says 1) there's no difference in the intensity of her love for the two kids, and 2) she believes she couldn't get pregnant because her daughter had to "find" her and be adopted into her family first.
At 45 I decided I wanted a baby. I got pregnant at 45-1/2, with very little intercourse. I had an uneventful pregnancy with no nausea, and I was only tired for an hour or so on two occasions. I had a natural vaginal delivery and my son is perfect. I'm incredibly lucky and was motivated to change my mind about having a baby due to all the infertility around me. I swam every day until two weeks before the birth, when I felt like quitting. The day I went into labor (13 days before due date), I walked on the pier at the Berkeley Marina, ate hot Mexican food, sat at an outdoor cafe, went home when my water broke, went to the hospital when my contractions were down to four minutes and gave birth five hours later. I never went to Lamaze classes because I thought they would scare me, and I knew I knew how to relax and breathe because of years of martial arts and yoga. I also thought that women have been having babies for thousands of years and that I could too.
I always had a hopeful, positive can-do attitude, I ate lots of food while I was trying to get pregnant, and I've always been very athletic. I guess I'm just lucky, and I pray it happens to everyone else who wants one. The best moment in my life was when amnio went ok, because with any woman that age there is a one in 38 chance of the baby having the 23rd chromosome be defective. I'm not bragging, just trying to give hope to people who are trying so hard. I hope they all get lucky like Andrea (from the last Digest) and me.
I'm never tired now; I don't feel like an older mom, except for the infinite joy, wisdom, and patience part.
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text: Thirty five individuals who all make their living in some form or another by addressing large audiences, attended the launch meeting of the Professional Speakers Association of Namibia earlier this month. The meeting was convened by a former president of the Professional Speakers Association of South Africa, Dr Gustav Gous. As a born Namibian, he noticed the demand for a self-regulatory body as his local client base grew. The association was officially constituted on 11 May after two pilot. Continue reading

subset: commoncrawl


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About KillSwitch
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- Gender* Male
- Ford Model Fiesta
- Ford Year 2003
- UK/Ireland Location Down
- Annual Mileage 10,001 to 15,000
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KillSwitch started following Mk6 Gem Wiring Diagram
Mk6 Gem Wiring Diagram
KillSwitch posted a topic in Ford Fiesta ClubHi guys does anyone know were i can get the GEM wiring for the MK6
(2003) Mk6 Key Coding Problem
KillSwitch replied to KillSwitch's topic in Ford Fiesta Clubyea i got the right key and got it got cut right
KillSwitch started following (2003) Mk6 Key Coding Problem
(2003) Mk6 Key Coding Problem
KillSwitch posted a topic in Ford Fiesta ClubHi guys, i got FOB uncoded and a new blade cut, i have 2 other keys coded to my car that i used to try and code this new FOB key, when u do the coding bit and put the new key in to be coded it does not code right, it will start the engine ( the red light still stays on ) untill u take the key out then it dont work agen, but it opens and closes the doors. ( not remotely ) i dont understand whats going wrong, if it was not coding AT ALL surely it wouldnt even start the engine ? shes a "2003 Fiesta Finesse"
Welcome to the Ford forums KillSwitch :)


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|10 commandments for DOS
|beer v. woman
|beer v. cucumber
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|buy cars like buying computers
|cat dictionary
|10 reasons for being ...
any nationality
|select a programming language
|let it be ... write in C ...
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|you are a computer geek when
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|deal of the week
|corporate lingo
|make your own country song
|program in C
|a career in crime
|real computer scientists
don't write code
|computer - male or female?
|Humor on paper
|dog v. cat
|things to do while
taking a driver's test
|ways to dump annoying dates
|application to live
in eastern washington
|fun things to do in an elevator
|real software engineers don't
|engineers' terminology
|english english everywhere ...
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football player version
|fun things to do in a final
that does not matter
|some suggested excuses
|unexpected finals
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like microsoft
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for long
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text:
There's a mountain of statistics to back up Pete Carroll's decision to go for it on fourth-and-1 Sunday in the Seahawks' loss at Atlanta. It just didn't work out this time.
RENTON — The Seahawks needed about 18 inches.
Instead, they lost more than two feet on a fourth-down play that kept them scoreless in the second quarter Sunday in Atlanta and had a city second guessing its coach after the Seahawks' season ended.
Think Pete Carroll should have opted for a second-quarter field goal instead of handing the ball to fullback Michael Robinson on fourth-and-one?
Me, too.
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But David Romer doesn't necessarily agree.
Now, he didn't watch Sunday's game between the Falcons and the Seahawks. Romer is an economics professor in California who chooses not to talk about NFL fourth-down strategies anymore. But anyone who's interested in anything more than knee-jerk condemnation of coaching decisions that don't pan out should take a minute to consider that Carroll made the right decision according to the years of NFL data Romer analyzed in his study of fourth-down decision-making that was published 10 years ago.
This isn't an argument anyone in Seattle wants to hear right now. Carroll's decision can't be right because it turned out so wrong. Not only was Robinson stopped for a loss, but the Falcons took over possession and scored a touchdown. And no sooner had Seattle lost by two points than everyone was pointing out the chance to go for three points that Carroll passed up.
"I of course wouldn't have done it if I thought we weren't going to make it," Carroll said.
It's the reasons he made that decision that are as important as the result if we're going to offer a fair critique of Carroll's decision to go for it.
Short stuff
"I wasn't concerned that we couldn't handle the line of scrimmage," Carroll said.
Why should he have been?
The Seahawks had gone for it on fourth-and-one three times in the regular season and converted all three. Not only that, they converted 16 of 23 third-and-one plays in the regular season, tied for the seventh-best percentage in the NFL.
Sure, Seattle was stuffed on third-and-one that drive, but that was the result of a miscommunication. Quarterback Russell Wilson was trying to audible out of the play and the noise drowned it out. The result was a play that was undermined before the ball was snapped.
"We made a mistake," Carroll said. "With another shot at it, we felt like we'd knock it out."
And while it was Robinson who carried the ball, not Marshawn Lynch, it's worth remembering that Robinson was Seattle's most successful short-yardage rusher this season. He converted six of seven third-and-one rushing attempts in the regular season, among the best in the NFC.
Risk vs. reward
"We wanted to make something happen," Carroll said. "We needed a spark. We needed to see if we could take advantage of it. I don't want to give them the ball back with just a three-point take-away."
Down 13-0, Carroll was thinking big. While that might seem headstrong in retrospect, his aggressiveness can be justified from a risk-reward perspective.
That's what Romer, the economics professor, concluded when he published his study. He said NFL coaches are too timid, usually choosing to kick instead of going for the first down in hopes of continuing to the end zone.
His statistics found that teams were often better-off going for it if they needed three yards or fewer on fourth down, and the odds generally increased in the opponent's half of the field.
Romer declined to be interviewed on the subject Monday when reached in his office, as he's decided to focus on his real job in economics rather than being the guy everyone calls to question the conservatism of NFL coaches.
But the situation Seattle faced on that fourth down Sunday cuts to the heart of his thesis, which is that the rewards of going for the first down and potentially earning a touchdown usually outweigh the risk of being stopped in a fourth-and-one situation. The probabilities involved in the specific situation Seattle faced in this game made it even more advantageous for Seattle to go for it, because the Seahawks were at the opponent's 11-yard line and, should they turn the ball over on downs, the Falcons would have worse field position than they would likely have on a kickoff after a field goal.
The odds favored Seattle's decision to go for it. It just so happens that, this time, the most likely scenario didn't occur.
The bottom line
I would have opted for the field goal.
The Seahawks were down 13-0, they had driven into Atlanta's half of the field for the second time and they needed something to show for it.
But my opinion is more about instinct than evidence, and I tend to be risk-averse. It's why I can count on one hand the number of times I've played blackjack in a casino and it's the reason I get nervous if I arrive at the airport fewer than 90 minutes before takeoff.
And while I might not have agreed with Carroll's decision to go for it on fourth down even before Robinson was stopped, it's still impossible to say he was wrong. At least not with the mountain of evidence that can be marshaled to justify the risk.
Danny O'Neil: 206-464-2364 or email@example.com.


text:
Oct. 18, 2013
By Kasandra Martinson
MORAGA, Calif. ---The Fresno State men's tennis team finished its first day of Intercollegiate Tennis Association Northwest Men's Regional tournament with seven singles victories on Friday at the Moraga Country Club in Moraga, Calif.
The Bulldogs started the day of competition off strong, winning 5-of-7 singles matches in the round of 128. Ethan Lopez, Sai Kartik Nakireddi, John Darmstaedter, Adriaan DuToit and Sam MacNeil all advanced to the singles round of 64.
Darmstaedter and MacNeil were the only 'Dogs to win their matches in the next round. Darmstaedter came from behind to defeat Pacific's Daniel Alameh (3-6;6-4;6-4). MacNeil won his match over Jayson Amos of Oregon in three sets (3-6;6-1;6-2). Darmstaedter and MacNeil will advance to the singles round of 32 on Saturday afternoon.
Fresno State is set to compete in doubles play tomorrow morning, continued singles matches will follow directly afterwards.
To view the full draw and tournament schedule click here.
Day 1 Results
Singles -- Round of 128
FS Sai Kartik d. UW Wendell Watanabe 6-1;6-3
FS Sam MacNeil[17] d. PAC Alex Hamilton 7-5;1-6;7-5
FS Ethan Lopez d. SM Seif Elsherbini 7-5;7-6(1)
FS Adriaan DuToit d. PSt Ian Risenhoover 6-1;6-1
FS John Darmstaedter d. SAC Joaquin Marquez 6-2;6-1
SM Thomas Hunt d. FS Felipe Fritz 4-6;6-3;6-0
ST Anthony Tsodikov d. FS Nikolas Papic 6-1;6-1
Singles -- Round of 64
FS John Darmstaedter d. PAC Daniel Alameh[17] 3-6;6-4;6-4
FS Sam MacNeil[17] d. OR Jayson Amos 3-6;6-1;6-2
USF Nils Skajaa[17] d. FS Ethan Lopez 7-6(4);6-2
SM Joakim Norstrom[9] d. FS Adriaan DuToit 6-4;6-2
PAC Sem Verbeek[9] d. FS Sai Kartik 6-3;6-0
"Catch the Wave"--Stay connected with the Bulldogs on Facebook (fresnostateathletics), Instagram (fresnostateathletics) and Twitter (@FSAthletics)
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text:
For Adam Wertheimer, the nationwide trend of baby boomers moving from green-lawned subdivisions to urban high rises has meant a lot of business.
Wertheimer is a project manager with BOWA, a Bethesda-based home design and remodeling company. In the past three years, an increasing percentage of the firm's business has come from luxury condo renovations.
"People are moving out of these single family homes in Bethesda and Potomac and into condos in Bethesda, Chevy Chase and Northwest D.C.," Wertheimer said. "We hear the same thing all the time: They don't want the maintenance and they don't need the big house."
A lot has been written recently about baby boomers downsizing with apartments in walkable, urban areas.
According to the U.S. Census Bureau's American Housing Survey, almost 10 percent of households age 55 and older in cities lived in condos in 2011, up from 7.3 percent in 2005 despite a shortage of condos.
"Baby boomers are tired of mowing the lawn," George Washington University land use expert Chris Leinberger told the Wall Street Journal. "They're looking for a more diverse environment."
In our area, Wertheimer says that translates to a lot of 50- and 60-plus-year-olds moving into condos like the Somerset House and Parc Somerset in Chevy Chase and the Park Potomac just west of I-270 near Montrose Road.
"They really like having the elevator accessibility and easy parking. There are a lot of conveniences," Wertheimer said.
And more and more people are realizing that while there are limitations, condo units can be remodeled.
Montgomery County requires a commercial permit for major condo renovations, the intricacies of which can be a learning process from former homeowners who have had an addition put on to their homes.
Luxury condo renovators like BOWA can shift walls and rework spaces to give a space a new look. But condo buildings usually don't allow work to touch the parting wall shared by two units. Builders must also deal with common mechanical systems, plumbing that can't be modified and buildings that include commercial space that typically means concrete floors or ceilings.
Most luxury condo rebuilds involve trim work molding and other design work.
Wertheimer said most of his projects involve condos that are five to 10-years-old. The new batch of luxury condos that have hit the downtown Bethesda market haven't required much work.
"A lot of companies try to get into condo renovation and struggle because they're not used to dealing with building management," Wertheimer said. "But we've seen a huge surge in people who don't want their unit to look like the other units in the building and who are looking for their unit to function in specific ways."
Photos via BOWA
The Enchanted Forest theme park closed for good in the 1990s. But the owner of a nearby farm has moved and preserved many of its parts.


text:
Writer and broadcaster Mark Kermode will become The Observer's new resident film critic next month. Kermode, 50, will replace critic Philip French, who is retiring at the beginning of September shortly after his 80th birthday, having written for London daily The Guardian's sister weekly Sunday newspaper for 50 years.
Kermode said that he was inspired by French: "No-one can match his breadth of knowledge or elegance of expression, but I hope I can bring to the role the passion for cinema which Observer readers expect." Kermode started writing reviews for The Observer in 2002. Lately he has delivered a weekly DVD review column. He is currently a contributing editor to Sight & Sound.
He also presents the "Kermode and Mayo's Film Review" on BBC Radio 5Live, and "The Film Review" on the BBC News Channel. He is also a presenter for BBC2's "The Culture Show" and writes and presents the bi-weekly BBC video-blog "Kermode Uncut." He has written several books on cinema including The Good, the Bad and The Multiplex: What's Wrong with Modern Movies, and Picador will publish his latest book "Hatchet Job – Love Movies, Hate Critics" in October.


text:
As far as holiday gifts go, a brand new shiny zEnterprise wouldn't be too shaby,* and there is enough of a lull in the beginning of the new year for planning that a webcast like Tivoli for zEnterprise – Speeding problem isolation and resolution makes a lot of sense to check out.
If you're new to zEnterprise or even if you've had your system for a while, this is a great opportunity to listen to speaker Randy Scott discuss this topic (and there will be a live question-and-answer session as well as a future replay).
Here's a brief description of the webcast and we look forward to you attending:
This in-depth look at Tivoli Application Management for zEnterprise can help you:
- Integrate end-to-end active and passive monitoring
- View and monitor workloads for composite applications, physical and virtual machines, groups and response times
- Use alerting capabilities for early detection of costly performance problems and outages


text:
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Histroy will be the judge of Rossi. Was he a great rider or, was he a good rider with great machinery .
My belief Rossi will be judged harshly if he does not win another Championship, so expect a bit of paint swapping.
Will Rossi give credit for the M1 development to JL or will he claim it the bike is relatively unchanged since he left.


text:
I'm thinking about riding in the Coast Guard Century in Portsmouth, VA in early August. I don't know the area well, but Portsmouth is part of the Virginia Beach/Norfolk/Hampton Roads metropolitan area, and I'm worried that the urban (?) environment will make for a no-so-bucolic century experience. Here's the information on the ride:
Can someone who knows the area tell me what they think of the quality of the route? Is it going to be endless stoplights and stop signs, or the pleasant harbor spin they seem to advertise?


text:
Knowledge Base - Technical Articles
Error: Could not get metadata record object
|Article ID:
|GIS Portal Toolkit 9.3
Error Message
When the 'Details' or 'Metadata' link of a search result record in GPT 9.3 is clicked, the following error message displays:
"Could not get metadata record object".
"Could not get metadata record object".
This is usually caused by a problem with the MetadataServer, the database connection, or the SDE service. The GIS Portal is not able to retrieve details or metadata for the record because it cannot access them.
Solution or Workaround
There are a number of things to check when this error occurs. Each of the following requires access to the environment on which the GIS Portal is installed and should be investigated one at a time to troubleshoot.
- Check that a port number is included in the cswServletUrl parameter of the gpt.xml file. This parameter appears on or about line 57. The cswServletUrl parameter should have a port number in it even if a redirector has been configured. The redirector may be slow to interpret the request and so the error occurs before the redirect can happen.
- Ensure that the GPT MetadataServer has been installed and that the MetadataServer service is started. This can be checked in the Windows Services dialog box. If the service is started, check that it is dependent on SDE by right-clicking the service, viewing its Properties, and verifying that the ArcGIS SDE service is listed as a service on which the MetadataServer depends.
- Check the Tomcat logs (located at <Tomcat Installation Directory>\logs) for reported errors. The two files to look at are the stdout.log file and the gpt.log file.
- Check the MetadataServer log files (located at <MetadataServer_Install>\log ) for reported errors.
a) Some database connection errors may be visible; if this is the case, check the SDEWORKSPACE settings in the PTWeblink.cfg file (located in the <MetadataServer_Install>\etc folder).The SDEWORKSPACE tag appears twice in this file. Check both instances.
b) If database connection errors are found in this file, correct them, save the file, and restart the MetadataServer service.
- Check that the ESRI license for ArcGIS SDE is up-to-date. The SDE service does not run if the license is expired. Because the MetadataServer service depends on the SDE service, if the SDE service is down, errors will be experienced when interacting with metadata in the Portal.
Created: 1/15/2009
Last Modified: 9/16/2009
Article Rating: (1)
By Anonymous - 11/20/2010 3:17 AM
I have suggested related resources/links that can enhance this article. See below.
i have do all the solutions and configuration is correct, and the metadata service is indexing and store the metadata record but still the problem found


text: Microsoft China Probing Microsoft In Antitrust Suit By Ross Reynolds & Amina Al-Sadi • Sep 2, 2014 Listen Listening... / 7:41 Ross Reynolds talks to Seattle Times economic columnist Jon Talton about the antitrust probe China has filed against Microsoft. Also, who will move to Federal Way now that Weyerhaeuser is moving to Pioneer Square? Teen Girl Loves Computer Science, But Struggles To Fit In By Ahlaam Ibraahim • Aug 26, 2014 KUOW Photo/Ahlaam Ibraahim Listen Listening... / 5:34 It was the first day of freshman year at Rainier Beach High School and everyone had first day jitters. The first period bell rang: computer science class. It wasn't a good experience for 16-year-old Ifrah Abshir. "I could never get it right," Abshir said. "Everything just kept crashing. Nothing worked, and I got mad, and I'm short tempered!" How Amazon's New Phone Competes In The Market By Amina Al-Sadi & Marcie Sillman • Aug 25, 2014 Courtesy GeekWire Listen Listening... / 8:14 Marcie Sillman talks to Todd Bishop, co-founder of Geekwire, about the new Amazon Fire phone, Steve Ballmer leaving the Microsoft board, and more tech news. Seattle: Up In The Computing Clouds By Ross Reynolds & Andy Hurst • Aug 21, 2014 Credit Flickr photo / Roy Kaltschmidt (CC-BY-NC-ND) Listen Listening... / 5:51 Ross Reynolds talks with Wall Street Journal technology reporter Shira Ovide about Seattle's role in cloud computing. Remember Superyacht Serene? Gates Family Is Vacationing Aboard By Carolyn Adolph • Aug 14, 2014 Wikimedia Commons European news media are reporting that Microsoft co-founder Bill Gates has chartered a luxury yacht owned by Stolichnaya vodka magnate Yuri Scheffler. The yacht, named Serene, is the third-largest superyacht in the world. The cost of chartering the boat runs around $2.1 million a week, according to Yacht Charter Fleet. That's roughly $212 a minute. Gates and his family are vacationing in Sardinia. They are reportedly using the yacht's helicopter to go ashore for tennis. The 'Cold War' Brewing Between Amazon And Hachette By Ross Reynolds & Amina Al-Sadi • Aug 11, 2014 Flickr Photo/Guillermo Esteves (CC-BY-NC-ND) Listen Listening... / 8:05 Ross Reynolds and Todd Bishop of Geekwire discuss the latest tech news. Amazon is in a battle with Hatchete over books and with Disney over the pre-order option on movies yet to be released. Also, data from an app suggests that, yes, there does appear to be a "Seattle freeze." From The Past To The Present In Our Communties By Ahlaam Ibraahim & Nia Price-Nascimento • Aug 6, 2014 KUOW Photo / Jenny Asarnow Listen Listening... / 15:57 What are the amazing stories in our community that get looked over? Nia Price-Nascimento learns about West Coast jazz by starting in her sub-basement, and Ahlaam Ibraahim shares how computer science has a huge affect on one girl's life. RadioActive is KUOW's program for high school students. Listen to RadioActive stories, subscribe to the RadioActive podcast and stay in touch on Facebook. Puget Sound's Economy: Taking Hits But Still Standing Strong By Jeannie Yandel & Amina Al-Sadi • Aug 4, 2014 Flickr Photo/Thomas Hawk (Cc-BY-NC-ND) Listen Listening... / 12:47 Jeannie Yandel talks to Jon Talton, economic columnist for the Seattle Times and writer for the blog Rogue Columnist, about the Puget Sound's economic climate. T-Mobile is for sale two companies, Spring and the French company, Illiad, are interested in buying it. Also, what is the biggest danger to the Northwest's economy? Massive Layoffs At Microsoft A Test For Seattle Startup Culture By Ross Reynolds, Andy Hurst & Amina Al-Sadi • Jul 21, 2014 Flickr Photo/Wonderlane (CC-BY-NC-ND)/http://bit.ly/1NM853Z Listen Listening... / 8:43 Last week, Microsoft began the biggest layoffs in the company's history: 18,000 total expected in the next year. So far, about 1,300 local workers have been affected. Jon Talton, business reporter for the Seattle Times, told KUOW's Ross Reynolds on The Record that this event is a test for the local economy. He said the Seattle area is in the midst of an economic boom – driven by Amazon, Boeing's 777X and 737, increased exports and low unemployment. Regrets: Do You Have A Few? By Bill Radke • Jul 18, 2014 KUOW Photo/Michael Clinard Listen Listening... / 52:31 Some Microsoft employees probably regret not taking that other job offer. Seattle's city attorney regrets bringing his pot to work. Should a Seattle theater company regret not casting any Asian American actors for its current show? And you'll regret it if you take I-90 westbound into Seattle next week. What else do you regret? And how would you tell your younger self to avoid regrets? What Happens After A Layoff By Ross Reynolds & Matthew Streib • Jul 18, 2014 Flickr Photo/Fabien Lavocat (CC BY-NC-ND) Listen Listening... / 7:08 Ross Reynolds talks with Kevin Osborne, vice president of client services at Waldron, a human resources consulting firm based in Seattle, about how downsizing companies may provide for laid off employees. An Update On The Microsoft Job Cuts And What It Means For The Region By Ross Reynolds & Amina Al-Sadi • Jul 17, 2014 Listen Listening... / 7:30 Ross Reynolds talks to Todd Bishop, founder of Geekwire, about the announcement that Microsoft will be cutting 18,000 jobs over the next year, including 1,351 in the Seattle region. Microsoft Layoffs Could Make Seattle Hub Of Cloud And Mobile Tech By Bill Radke & Isolde Raftery • Jul 17, 2014 Courtesy of Microsoft Listen Listening... / 4:59 KUOW's Bill Radke speaks with GeekWire's Todd Bishop about Microsoft's layoffs announcement. Listen Listening... / 3:24 KUOW's Bill Radke speaks with Nick Wingfield of The New York Times about Microsoft layoffs. Following the announcement by Microsoft CEO Satya Nadella that the company would undergo a 14 percent reduction in its workforce, conference rooms at the Redmond campus were reserved by the human resources. Major Memo Sent To Microsoft Employees By Ross Reynolds & Amina Al-Sadi • Jul 11, 2014 Flickr Photo/BagoGames (CC BY 2.0) Listen Listening... / 8:48 Ross Reynolds talks to Todd Bishop of Geekwire about Microsoft CEO Satya Nadella's 3,200 word, company-wide memo. Bishop picked out one key section of the missive: Nadella's pursuit of streamlining the company's engineering processes and being more responsive to the market and customers' demands. Facebook Expands Seattle Office Space, Studies Your Emotions By Marcie Sillman & Amina Al-Sadi • Jun 30, 2014 Listen Listening... / 6:22 Marcie Sillman talks to Todd Bishop, tech writer and co-founder of Geekwire about the growing tech industry in the Northwest and Facebook's secret study into manipulating the emotions of its users. Pages« first ‹ previous 1 2 3 4 5 6 next › last »


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The Ubuntu version of the library provided by IBM to accelerate HaplotypeCaller on their POWER8 systems (originally described here) has been updated to fix a bug. You can download it from the original DropBox link.
We all know how HaplotypeCaller analyses can take a long time. IBM is now providing a native implementation of the PairHMM algorithm that leverages the new hardware available in their POWER8 systems. This optimization currently work on the following systems: Ubuntu14 and RHEL7 with POWER8.
To take advantage of this optimization, you need to do the following:
libVectorLoglessPairHMM.so using
-pairHMM VECTOR_LOGLESS_CACHING
Here is an example for running on a P8 system with Ubuntu:
java -Xmx32g -Djava.library.path=/path/to/PairHMM_P8_Ubuntu -jar $GATK_PATH/GenomeAnalysisTK.jar \
-T HaplotypeCaller \
-R $REFERENCE -I $INPUT_BAM --dbsnp $SNP_VCF \
-stand_emit_conf 10 -stand_call_conf 50 \
--pair_hmm_implementation VECTOR_LOGLESS_CACHING \
-o $OUTPUT_VCF
The latest version of the library accelerates HaplotypeCaller using the same floating precision as Java on POWER8. Also, exploiting Simultaneous Multithreading (SMT) along with the vector instructions, it can accelerate HaplotypeCaller more than the previous version, in particular, in the single-thread mode (no
-nct option is specified). For example, the PairHMM computation, which the library accelerates, consumes about a half of the HaplotypeCaller runtime in the single-thread mode, 1.88x speed-up will be expected. The library uses 37% of the available processors by default. The number of threads can be tuned by setting the environment variable
PHMM_N_THREADS. The source code is available here.
If you have any questions or issues (aside from downloading the file), please contact Yinhue Cheng at IBM (email@example.com) or Takeshi Ogasawara at IBM Japan (firstname.lastname@example.com).
Disclaimer: Please note that these libraries are not an official IBM product. You use it entirely at your own risk, and neither IBM nor the author assumes any liability whatsoever, nor do they assume responsibility for maintenance. Please report comments and corrections to firstname.lastname@example.com.
This may seem crazy considering we released the big 3.0 version not two weeks ago, but yes, we have a new version for you already! It's a bit of a special case because this release is all about the hardware-based optimizations we had previously announced. What we hadn't announced yet was that this is the fruit of a new collaboration with a team at Intel (which you can read more about here), so we were waiting for everyone to be ready for the big reveal.
So basically, the story is that we've started collaborating with the Intel Bio Team to enable key parts of the GATK to run more efficiently on certain hardware configurations. For our first project together, we tackled the PairHMM algorithm, which is responsible for a large proportion of the runtime of HaplotypeCaller analyses. The resulting optimizations, which are the main feature in version 3.1, produce significant speedups for HaplotypeCaller runs on a wide range of hardware.
We will continue working with Intel to further improve the performance of GATK tools that have historically been afflicted with performance issues and long runtimes (hello BQSR). As always, we hope these new features will make your life easier, and we welcome your feedback in the forum!
Note that these optimizations currently work on Linux systems only, and will not work on Mac or Windows operating systems. In the near future we will add support for Mac OS. We have no plans to add support for Windows since the GATK itself does not run on Windows.
Please note also that to take advantage of these optimizations, you need to opt-in by adding the following flag to your GATK command:
-pairHMM VECTOR_LOGLESS_CACHING.
Here is a handy little table of the speedups you can expect depending on the hardware and operating system you are using. The configurations given here are the minimum requirements for benefiting from the expected speedup ranges shown in the third column. Keep in mind that these numbers are based on tests in controlled conditions; in the wild, your mileage may vary.
|Linux kernel version
|Architecture / Processor
|Expected speedup
|Instruction set
|Any 64-bit Linux
|Any x86 64-bit
|Linux 2.6 or newer
|Penryn (Core 2 or newer)
|Linux 2.6.30 or newer
|SandyBridge (i3, i5, i7, Xeon E3, E5, E7 or newer)
To find out exactly which processor is in your machine, you can run this command in the terminal:
$ cat /proc/cpuinfo | grep "model name"
model name : Intel(R) Core(TM) i7-2600 CPU @ 3.40GHz
model name : Intel(R) Core(TM) i7-2600 CPU @ 3.40GHz
model name : Intel(R) Core(TM) i7-2600 CPU @ 3.40GHz
model name : Intel(R) Core(TM) i7-2600 CPU @ 3.40GHz
model name : Intel(R) Core(TM) i7-2600 CPU @ 3.40GHz
model name : Intel(R) Core(TM) i7-2600 CPU @ 3.40GHz
model name : Intel(R) Core(TM) i7-2600 CPU @ 3.40GHz
model name : Intel(R) Core(TM) i7-2600 CPU @ 3.40GHz
In this example, the machine has 4 cores (8-threads), so you see the answer 8 times. With the model name (here i7-2600) you can look up your hardware's relevant capabilities in the Wikipedia page on vector extensions.
Alternatively, Intel has provided us with some links to lists of processors categorized by architecture, in which you can look up your hardware:
Finally, a few notes to clarify some concepts regarding Linux kernels vs. distributions and processors vs. architectures:
SandyBridge and Penryn are microarchitectures; essentially, these are sets of instructions built into the CPU. Core 2, core i3, i4, i7, Xeon e3, e5, e7 are the processors that will implement a specific architecture to make use of the relevant improvements (see table above).
The Linux kernel has no connection with Linux distribution (e.g. Ubuntu, RedHat etc). Any distribution can use any kernel they want. There are "default kernels" shipped with each distribution, but that's beyond the scope of this article to cover (there are at least 300 Linux distributions out there). But you can always install whatever kernel version you want.
Previously, we covered the spirit of GATK 3.0 (what our intentions are for this new release, and what we're hoping to achieve). Let's now have a look at the top three features you can look forward to in 3.0, in no particular order:
At this point everyone knows that the HaplotypeCaller is fabulous (you know this, right?) but beyond a certain number of samples that you're trying to call jointly, it just grinds to a crawl, and any further movement is on the scale of continental drift. Obviously this is a major obstacle if you're trying to do any kind of work at scale beyond a handful of samples, and that's why it hasn't been used in recent large-cohort projects despite showing best-in-class performance in terms of discovery power.
The major culprit in this case is the PairHMM algorithm, which takes up the lion's share of HC runtime. With the help of external collaborators (to be credited in a follow-up post) we rewrote the code of the PairHMM to make it orders of magnitude faster, especially on specialized hardware like GPU and FPGA chips (but you'll still see a speedup on "regular" hardware).
We plan to follow up on this by doing similar optimizations on the other "slowpoke" algorithms that are responsible for long runtimes in GATK tools.
Some problems in variant calling can't be solved by Daft Punk hardware upgrades (better faster stronger) alone. Beyond the question of speed, a major issue with multi-sample variant discovery is that you have to wait until all the samples are available to call variants on them. Then, if later you want to add some more samples to your cohort, you have to re-call all of them together, old and new. This, also known as the "N+1 problem", is a huge pain in the anatomy.
The underlying idea of the "single-sample pipeline for joint variant discovery" is to decouple the two steps in the variant calling process: identifying evidence of variation, and interpreting the evidence. Only the second step needs to be done jointly on all samples, while the first step can be done just as well (and a heck of a lot faster) on one sample at a time.
The new pipeline allows us to process each sample as it comes off the sequencing machine, up to the first step of variant calling. Cumulatively, this will produce a database of per-sample, per-site allele frequencies. Then it's just a matter of running a joint analysis on the database, which can be done incrementally each time a new sample is added or at certain intervals or timepoints, depending on the research needs, because this step runs quickly and cheaply.
We'll go into the details of exactly how this works in a follow-up post. For now, the take-home message is that it's a "single-sample pipeline" because you do the heavy-lifting per-sample (and just once, ever), but you are empowered to perform "joint discovery" because you interpret the evidence from each sample in light of what you see in all the other samples, and you can do this at any point in the project timeline.
Our Best Practices recommendations for calling variants on DNA sequence data have proved to be wildly popular with the scientific community, presumably because it takes a lot of the guesswork out of running GATK, and provides a large degree of reproducibility.
Now, we're excited to introduce our Best Practices recommendations for calling variants on RNAseq data. These recommendations are based on our classic DNA-focused Best Practices, with some key differences the early data processing steps, as well as in the calling step. We do not yet have RNAseq-specific recommendations for variant filtering/recalibration, but will be developing those in the coming weeks.
We'll go into the details of the RNAseq Best Practices in a follow-up post, but in a nutshell, these are the key differences: use STAR for alignment, add an exon splitting and cleanup step, and tell the variant caller to take the splits into account. The latter involves some new code added to the variant callers; it is available to both HaplotypeCaller and UnifiedGenotyper, but UG is currently missing a whole lot of indels, so we do recommend using only HC in the immediate future.
Keep in mind that our DNA-focused Best Practices were developed over several years of thorough experimentation, and are continuously updated as new observations come to light and the analysis methods improve. We have only been working with RNAseq for a few months, so there are many aspects that we still need to examine in more detail before we can be fully confident that we are doing the best possible thing. We will be improving these recommendations progressively as we go, and we hope that the researcher community will help us by providing feedback of their experiences applying our recommendations to their data.
Hi, I'm using multi-threading for HaplotypeCaller by setting the nct option. But actually, I found that the speedup it gains isn't in proportional to the increase of the number of data threads. I tried nct as 8,12,16,24 on my machine, and gained a speedup of 4.1x, 4.2x, 4.2x, 4.2x. Seems that there is an upper bound of performance gains when enabling mult-threading for HaplotypeCaller.
I'm wondering what each data thread stands for in HaplotypeCaller. We need to use PairHMM to calculate the likelihood array in each active region. Are we distributing each read-haplotype pair in the region as one data thread and map it to a CPU thread? Or are we distributing the calculation in each region as one data thread?
I want to switch back to Java LOGLESS_CACHING implementation for PairHMM instead of AVX, how can I make this? I think that I may need to change some argument but I don't know where to start.
Thanks, Jay
I'm using 3.3-0-g37228af.
This command gets around a feature that looks like a bug to me:
gatk -T HaplotypeCaller -R ref.fa -I in.bam -o /dev/stdout 2> log.txt | grep -v -e PairHMM -e "JNI call" | bgzip -s - > out.vcf.gz
As you see, one has to remove three lines of the stdout stream written by PairHMM. Like all other logging information, they should go to stderr.
The three lines look like this:
Using un-vectorized C++ implementation of PairHMM
Time spent in setup for JNI call : 3.3656100000000003E-4
Total compute time in PairHMM computeLikelihoods() : 0.008854789
Regard,s Ari


text:
The Bevis Marks Synagogue in the city of London is the oldest synagogue in the United Kingdom and has been in use for more than 300 years. Montefiore was a member of the Bevis Marks Synagogue and when he died, it was decided that his seat would no longer be in use and would be left as a memorial to him. The seat is cordoned and has a plaque with Montefiore's name on it.
One of the seats in the synagogue belonged to the notable philanthropist Sir Moses Montefiore, one of the most famous British Jews of the 19th century. A financier and a banker, Montefiore donated large sums of money to promote industry, education and health among the Jewish community in then-Palestine. His donations helped found the Jerusalem neighborhood of Mishkenot Sha'ananim in 1860.
The synagogue, which also known as Kahal Sahar Asamaim or Sha'ar ha-Shamayim is affiliated to London's Spanish and Portuguese Jewish community. "Everything here dates back from 1701," stated curator Maurice Bitton. "All this furniture is original. Nothing has been changed here in more than 300 years now." Bitton noted that the Bevis Marks Synagogue, which holds traditional Sephardic Spanish and Portuguese services, is the only synagogue in all of Europe that has had prayers continuously for more than three centuries.
Bitton explained that nowadays, the only people who are allowed to sit in Montefiore's seat are special dignitaries, such as former Israeli President Chaim Weizmann, former British Prime Minister Tony Blair, Prince Charles, and Prince Philip. "The most special thing about the synagogue is its age and its history," he stated. "It has been here for 309 years, and it has seen generations of Jews in this country. If these walls could speak they would tell a wonderful story."


text:
Eagle Scout: Enrico Christopher Galassi
eagle scout
Enrico Christopher Galassi
Enrico Christopher Galassi, 18, of Dickson City, has attained the rank of Eagle Scout.
Family: Son of Diane and Enrico Galassi; brother of Alyssa Galassi; grandson of Dolores and Edward Zitterman, Eynon, and Mary Ann and Nazzareno Galassi, Scranton.
School/Community: Senior honor roll student at Holy Cross High School; four-year member of cross country and track and field teams; member of a cappella group; Scholastic Art Gold Key award winner for animation; member and 10-year altar server at St. Mary's Visitation Church, Dickson City.
Scouting Career/Awards: Member of Troop 21, St. Mary's Visitation Church; began his Scouting career as Tiger Cub and progressed through the other ranks of Wolf and Bear; as Webelo earned the Light of Christ and Parvuli Dei religious awards, and the Arrow of Light; progressed through ranks of Tenderfoot, 2nd Class, 1st Class, Star, Life and Eagle; served as scribe, assistant patrol leader, patrol leader, assistant senior patrol leader, and senior patrol leader; earned the Ad Altare Dei and Pope Pius XII Religious awards from the BSA, and the St. Michael the Arch Angel award from Troop 21; Brotherhood member of the Order of the Arrow Lowwapaneu Lodge 191.
Eagle project: Restoration of a multi-use trail at the Lackawanna State Park; in cooperation with park, restored an extensive section of multi-use hiking and biking trail; rock-armoured and elevated sections of trail for proper water drainage; planned and led fellow scouts, leaders, and volunteers from the park, saw to collection of rocks from surrounding areas.
Ceremony: Eagle Court of Honor, Feb. 3, at St. Mary's Visitation Church and dinner at La Buona Vita.
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text:
Festive Cranberry Dessert Squares Recipe
From Thanksgiving through Christmas, you'll find these tart and tasty treats at our house. Although the recipe uses a convenient mix, it's made-from-scratch scrumptious!
- 1 cup fresh or frozen cranberries
- 2 tablespoons sugar
- 1 package (15.6 ounces) cranberry-orange quick bread mix
- 1 cup quick-cooking oats
- 2/3 cup butter, melted
- 2 tablespoons brown sugar
- 1/3 cup all-purpose flour
- 1 cup butterscotch caramel fudge ice cream topping
- 1-1/2 cups chopped dates
- 1 cup chopped walnuts
- 1. In a small bowl, combine cranberries and sugar; set aside. In a large bowl, combine the quick bread mix, oats, butter and brown sugar; set aside 1 cup for topping. Press remaining crumb mixture into a greased 13-in. x 9-in. baking dish.
- 2. Bake at 350° for 10 minutes. Meanwhile, combine flour and ice cream topping until smooth; set aside. Sprinkle the cranberry mixture, dates and nuts over crust; drizzle with ice cream topping mixture. Sprinkle with reserved crumb mixture.
- 3. Bake for 25-30 minutes or until golden brown and bubbly. Cool on a wire rack. Serve warm or cold. Store in the refrigerator. Yield: 15-18 servings.
Nutritional Facts
1 serving (1 each) equals 334 calories, 14 g fat (5 g saturated fat), 23 mg cholesterol, 249 mg sodium, 50 g carbohydrate, 3 g fiber, 5 g protein.
Reviews for Festive Cranberry Dessert Squares
Reviewed Aug. 28, 2013
"Cut in small bars. So tasty & nice for Christmas or Valentines treat.MJG"
Reviewed Aug. 28, 2013
"It is yummy! In place of the boxed bread mix you can use 2 c. each flour & quick oats, 1/2 c. each sugar & brown sugar, 1/2 tsp. baking soda."
© 2016 RDA Enthusiast Brands, LLC


text:
(2-Minute Preview)
This content is for members only.Buried at the base of the Layer Style dialog, the Blend If sliders are among Photoshop's most mysterious and least understood compositing features. Given their extraordinary power, it's a shame that more people don't use them. In this Photoshop Workbench, I intend to demystify these sublime sliders.
To explore the Blend If sliders, we'll use a three-layer document. The bottom layer is a photograph with a broad range of tonal values. The second layer is a grayscale step wedge. The top layer contains the entire color spectrum. We'll work with two layers at a time, sometimes turning layer visibility off and on.
Their are three ways to access the Blend If sliders:
1) Choose Layer>Layer Style>Blending Options.
2) In the Layers panel, double-click in the empty space to the right of a layer name.
3) Click on the Add a layer style icon at the base of the Layers panel and choose Blending Options.
At the base of the Layer Style dialog is a box labeled "Blend If." By default, the pull-down is set to Gray. Within the pull-down, there are also Red, Green, and Blue options.
Beneath the Blend If pull-down are the blending sliders. The "This Layer" sliders are used to make parts of the active (top) layer invisible. The "Underlying Layer" sliders are used to visually "pop" parts of the underlying layer through the top layer.
During this lesson, you'll notice that moving any of the sliders creates a noticeable "tear" in the picture. In most cases, it's more desirable to produce a smooth blending transition. To achieve this, at the very moment when tearing occurs, hold Option (PC: Alt) and grab the inner half of the slider to split it in two. Continue to drag this half to create a smooth transition.
To illustrate all that these sliders offer, we'll first explore them by blending the "Grayscale" layer with the underlying picture. Then, we'll blend the "Colors" layer with the underlying picture.


text:
In BEST WESTERN Los Andes de America Hotel we have always believed that our activities should have a positive impact in the community where we operate and in our environment.
That is why we seek for the viability of our business activity, and at the same time we work together with our staff, our visitors and our society in order to contribute to the development of our community, to preserve our cultural heritage and to protect our environment.
Since 2008 we have been working with the Rainforest Alliance training, developing and implementing best sustainable practices based on Global Sustainable Tourism Criteria.
In September of 2011, we obtained the International Verification Seal of "The Rainforest Alliance Verified TM", for Sustainable Tourism.
We work under 3 sustainability criteria:
1. Managerial
2. Socio-Cultural
3. Environmental
We are committed to be socially responsible and to support the development of the community where we operate. We seek to support the development of our employees, their families and our community; and to preserve and promote the Andean culture.
- Andean Communities Weaver Artisans:
We have developed a program to support the weaver artisans of Sicuani, San Jeronimo and Cusco Andean communities providing them training and organizing trade fairs, where they can sell their products and have a culturally interaction with our visitors.
- Organization of Events and Activities in our Hotel:
- Community Services:
Together with our employees and with our partners support, we develop programs to support the communities where we have our business activities.
- Diversity and Inclusion:
We are committed to ensuring that our work supports a healthy environment. We seek to prevent, decrease or eliminated our environmental impact.
Since 2000 we have started to develop environmental management processes with the ISO 14001 System; which has been complemented in 2008 with the implementation of best environmental practices; with the technical assistance from the Rainforest Alliance.
- Building a Green Hotel:
- Energy Conservation:
- Water Conservation:
- Waste Management and Recycling:
- Raw Material and Inputs:


text:
How Much Does Kiwi Fruit Cost?
Kiwi fruit is one of the many fruits available for human consumption. Before the advent of processed food, fruits and vegetables were the main components of the food we ate. Even though other foods may be more readily available and cheaper, fruit is a very imporant part of your diet. Fruit is very heathly and the kiwi is rich in vitamins C, E and A as well as a good source of potassium. Kiwi can be mixed with other fruits or can be eaten by itself.
How much is it?
- There are several varieties of the kiwi fruit available and this is one of the factors why the price of the fruit can vary. The availability of the fruit in the market would also affect the price since it is not available in every area and is more available certain times of the year. The laws of supply and demand and the competition among grocery stores will also affect the price.
- On average, kiwi at a local grocery store or market can cost $0.25 to $0.75 per fruit. It is not uncommon for grocery stores to have them on sale for 4 for a $1.
- Kiwi can often come as a dried fruit snack. As a dried fruit, plan on spending anywhere from $2 to $5 per pound. For example, a five pound case of dried kiwi can cost $19 to $25.
- An online retailer such as Hirt's Gardens offers kiwi fruits as well as other plants, and you can purchase them any day of the year. The price of kiwi fruit according to the site can range from $5 to $30.
What is going to be included?
- Kiwi fruits boast several flavors and textures; they have the characteristics of pineapple, strawberry and melon. There are several varieties of kiwis available and they each have different colors. The more popular ones are green while there are also yellow varieties of the fruit.
- Kiwi can be made into different byproducts that can be beneficial to the body. Since the fruit has several nutritional benefits, different companies have manufactured the fruit to be used in different health and beauty products.
What are the extra costs?
- There are certainly no additional costs involved when you buy kiwi fruit unless you buy it online since online stores would often charge for the shipping and handling of the product. The cost to ship the fruit would depend on the location from where the product would come and the number of kiwis ordered.
Tips to know:
- Kiwis can be used as garnish to add your favorite drinks; they are also a great addition in any fruit salad. You can also preserve kiwis which exponentially increases its flavor.
- Choosing fresh fruits is an important part when buying them. When you choose kiwis, look for unwrinkled and unblemished kiwis. You should also store them in room temperature away from other fruits since they will ripen quickly.
How can I save money?
- You can save money by browsing different websites that sell kiwi fruit. Fresh kiwi fruit is available in different online stores and can be purchased at discounted price. When you buy in bulk, the seller usually reduce the price of the fruit.
- Kiwi is a seasonal fruits that grows in abundance in a particular season. They are considerably cheaper during this time of year compared to when they are not in season. When in season, consider looking at local farmer's markets to receive the most in savings.
Average Reported Cost: $0
Less Expensive $1 $1.5K $3K $5K $6.5K More Expensive $8k


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My Best Birth
How do people pay for home birth? For the last three months my husband and I have been planning for a home birth, and my insurance (Anthem) covered our midwife. Today I found out that my company is changing insurance companies to a local company (that happens to be owned by the local hospital). This means no midwife coverage. In fact, this insurance company told a friend of mine that home birth i…
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