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The Division on Technology and Logistics (DTL) aims to enhance the economic development and competitiveness in developing countries - in particular Least Developed Countries - through efficient trade logistics services and transit transport systems; science, technology and innovation, including increased access to and sustainable use of information and communication technologies; and training and capacity-building programmes for local institutions.
The Division achieves this through analytical work, intergovernmental policy dialogue and the implementation of technical cooperation, training and capacity building programmes.
The Division consists of three Branches, hosts the United Nations Commission on Science and Technology for Development and carries out ASYCUDA, UNCTAD´s largest technical cooperation programme.
A maritime country profile provides a basic snapshot of a country's situation regarding maritime transport and international trade, facilitating convenient cross-country comparisons. The Maritime Country Profiles will be updated regularly as new data becomes available.
Nearly two-dozen managers from 19 ports across the Philippines recently presented the recommendations from case studies conducted as part of UNCTAD's training programme. Port authorities, encouraged by the results, committed to continuing and strengthening the programme.
UNCTAD launched the flagship report on 16 December at an event organized with the Government of Kenya on the margins of the 10th Ministerial Conference of the World Trade Organization.


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I've lost 74 lbs since March 21, 2011, and I'm really excited to join the cycling community. I currently weigh 365 pounds, but by the time I actually buy a bike in December I should be just a bit under 350.
I plan to ride 50/50 road and trail since there's a nice trail less than a mile away from my house. The trail is really easy terrain, no hills, but it is mostly rocks and dirt. I don't plan on doing any jumping anytime soon. So for now most of my riding should be easy. I'm not so much worried about the terrain I'll be riding so much as I am about a bike even just holding my weight. As I get more experienced and drop some more weight though I would like to do some harder trails. So, should I look for front suspension mountain bikes?
Some mountain bike suggestions would really be helpful. My maximum price range would be $1,000.

subset: commoncrawl


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After importing thousands of messages from a pop server, they display in Zimbra mail with a "Received Date" set to the date they were imported, rather than the original received date.
I'm sure there was a better way to import the messages that would have preserved the info (IMAP wasn't an option), but there it is.
So I have a need to alter the "Received Date" displayed in Zimbra Mail to match the sent date on the messages (which will be close enough). I assume this means a sql update script. But I'm having trouble guessing what columns in which tables need to be tweaked.
Any help appreciated!


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Key things you need to know aboutDr. Teasdall:
Dr. Teasdall's Experience
Research training, expertise and qualifications
Dr. Teasdall's Specialties
- Ear, Nose, and Throat
Procedures Dr. Teasdall Performs
- Adenoidectomy
- Diagnostic Nasal and-or Sinus Endoscopy
- See all 19 procedures
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Patient Satisfaction
Patients' feedback on their experience with Dr. Teasdall
Likelihood of recommending Dr. Teasdall to family and friends is 5 out of 5 5 1 3
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- Bogard & Teasdall Mds
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Newegg.com - A great place to buy computers, computer parts, electronics, software, accessories, and DVDs online. With great prices, fast shipping, and top-rated customer service - once you know, you Newegg.
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Great feel but way to floppy and collected lint
This review is from: Insten Black 1X Silicone Case For iPhone 5 / 5S 739001
Pros: Loved the feel, "warm" touch.
Cons: Way too floppy, every time I took it out of my pocket I had to put it back on.
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Greg Gonzalez, a junior from San Bruno, Calif. (Skyline JC), recorded a 7.0 inning complete game no-hit performance last week, helping the Bulldogs to a 1-0 shutout victory at Hawai'i. Gonzalez became the seventh Bulldog to pitch a no-hitter and the first in 34 years to achieve the feat. The performance marked his first collegiate start as a Bulldog as he faced 22 batters, just one over the minimum of 21. Gonzalez sat down 17 consecutive batters and the only blemish to his near perfect game was a pair of walks. He also registered seven strikeouts on the night.
Other Nominees:
2009-10 Athletes of the Week:
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Western France Welcomes New Power Plant
A new combined-cycle power plant at Montoir de Bretagne in the Loire Atlantique region of western France has been inaugurated, according to GE. The plant is currently producing 435 MW of power, which is enough to power about 450 000 households.
The new combined-cycle facility features a GE 109FB combined-cycle system, including a Frame 9FB gas turbine, a high efficiency advanced technology (HEAT) steam turbine and associated generators. The 9FB is an air-cooled 50 Hz gas turbine and the largest member of GE's family of F-technology machines, GE said.
The 9FB for the GDF SUEZ project was manufactured at GE's European gas turbine headquarters in Belfort, France, and shipped to Montoir de Bretagne in early 2009. In combined-cycle operation, the 9FB delivers an energy efficiency of more than 58%. The 9FB is also equipped with GE's dry low NOx combustion system, which limits NOx emissions to 25 ppm or less, the company said.
The plant is owned and operated by GDF SUEZ, the French multinational energy company, which will use it to provide additional electricity to the South Brittany region.
For more information: www.ge.com


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Paramvir Bahl, Matthai Phillipos, and Lin Zhong
25 June 2012
We argue that for computers to do more for us, we need to show the cloud what we see and embrace cloud-powered sight for mobile users. We present sample applications that will be empowered by this vision, discuss why the timing is right to tackle it, and offer our initial thoughts on some of the important research challenges.
|Publication type
|Published in
|International Workshop on Mobile Cloud Computing and Services (MCS)
|Association for Computing Machinery, Inc.
Robert LiKamWa, Bodhi Priyantha, Matthai Philipose, Lin Zhong, and Paramvir Bahl. Energy Characterization and Optimization of Image Sensing Toward Continuous Mobile Vision , ACM International Conference in Mobile Systems, Applications, and Services (MobiSys), 2013.


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Want to be part of Toronto's most passionate and dynamic team of professional fitness coaches?
Do you have a passion for fitness, adventure and inspiring the active lifestyle in others? Think Fitness Studios could be the career path for you. We are always in search for the next key player on our team of fitness specialists. If you think this might be you, we invite you to review the qualifications and apply today.
- Degree/Diploma (kinesiology, exercise science or equivalent is an asset)
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- Required to undergo in-depth integration prior to start
- Provide professional and qualified personal training services and/or class instruction to an array of clientele
- Programming, fitness evaluations
- Participate in fitness events
- Hourly wages for trainers
- Salaried positions for additional roles
- Competitive incentive packages offered
- Company perks
- Great opportunity for management and growth
How to Apply
Resumes may be sent to firstname.lastname@example.com.
Serious candidates only, please.


text: Welcome to North Irving living at its finest, Clarendon Apartments. Take advantage of your free time as you enjoy a refreshing swim in our pool and let your troubles melt away, or enjoy a vigorous workout in our state-of the-art fitness center. Visit our photo gallery to experience the luxurious life that awaits you when you decide to call North Irving apartments home.


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Home > Archives
Monday, 1 January 0001 | MYT 12:00 AM
Tuesday March 1, 2011
By LEONG HUNG YEE firstname.lastname@example.com
KUALA LUMPUR: Maxis Bhd's net profit rose 21.3% to RM610mil for the fourth quarter ended Dec 31, 2010 from RM503mil previously due to increased contribution from the non-voice segment and a bigger subscriber base.
Its revenue rose to RM2.31bil versus RM2.21bil previously.
"The group recorded a quarter-on-quarter revenue growth of 4% or RM94mil primarily driven by an increase in non-voice revenue by RM84mil or 10% to RM893mil. This was contributed by advanced data services, short message service and wireless broadband businesses, partially offset by reduction in interconnect revenue," Maxis said in the notes accompanying its financial results.
The telco's profit from operations stood at RM887mil while earnings per share was 8.10 sen against 6.70 sen posted a year ago.
However, Maxis said the comparative figures did not represent a like-for-like comparison of the operational performance of the group because of the accounting treatment adopted for the business combination by Maxis, which was completed on Oct 1, 2009.
Maxis' EBITDA (earnings before interest, taxation, depreciation and amortisation) margin for the fourth quarter was lower at 50.6% against 51.4% in the preceeding quarter.
During the quarter, Maxis also declared an interim dividend of 8 sen per share and also proposed a final dividend of 8 sen per share totalling up to a RM1.2bil payout.
For the full financial year ended Dec 31 (FY10), Maxis' net profit stood at RM2.3bil on revenue of RM8.87bil. Its EBITDA margin for the year stood at 49.8%.
As at Dec 31, the company had a cash and cash equivalent of RM898mil.
Chief executive officer Sandip Das said Maxis had managed to maintain its EBITDA margin close to 50% level despite margin contraction pressure in its voice segment last year.
"The sluggishness or maturity of the voice market came much faster than we thought," he said at a briefing yesterday.
Going forward, Das expects growth to come from data and broadband. He said the company had spent the past two years since its re-listing in late 2009 building a strong network.
"We need to build (the network) for the tsunami that's to come ... the tsunami for data and broadband," he said, adding that Maxis managed to secure 330,000 net adds in the broadband segment in FY10 to a total of 594,000 subscribers.
As at Dec 31, Maxis' had a total of 13.95 million subscribers while its prepaid subscribers crossed the 10 million mark.
To a question, Das said expected Maxis to achieve a mid-single-digit growth revenue for FY11 to be driven by non-voice services, including data and broadband.
He said non-voice revenue was among the global best in the FY10, accounting for 41.5% of mobile revenue contribution.
"We aim to increase the contribution to 50% by mid-2012. The company will continue to maximise its mobile revenue and continue to be the leader in the market," he said.
On capital expenditure for FY11, Das said the company planned to spend RM1.4bil, of which 40% to 50% would be used to upgrade its 3G network including fibre optic build-up, and about RM300mil for the infrastructure of its fixed line.
One focus this year would be the commercialisation of home services which would take effect next month, he said.
Among the services to be offered include IP-based services (to be delivered over high-speed broadband access), interactive television, telepresence and eHealth hosting services.
Maxis' blended average revenue per user (ARPU) stood at RM51 against RM56 a year ago.
Its prepaid ARPU fell 12% to RM36 in FY10 from RM41 previously while wireless broadband ARPU fell 30% to RM68 from RM97 in 2009.
Chief financial officer Rossana Rashidi said the prepaid ARPU was partly cannibalised due to lifetime schemes and youth plans, which were now being phased out, and revenue-enhancing plans were being introduced.
She said the lower broadband ARPU was due to promotion packages used to encourage take-up from fresh segments.
Teen forced to be sex slave by her friends
Man and girlfriend beaten up in middle of road by Kedah rep
Good Samaritan saves mother and daughter on KTM Komuter
Boy's sex act with sister 'learnt from dad's friend, stepbrother'
Boy sleeping outside home eaten by lion
Man tracks down thief who snatched girlfriend's handbag
Copyright © 1995- Star Media Group Berhad (ROC 10894D)


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Lauren Fendrick
Birth Year: 1982
Resides: Hermosa Beach, Calif.
Height: 6-1
College: UCLA
Web Site: www.laurenfendrick.com
View Lauren's statistical bio on BVBInfo.co
Follow Lauren on Twitter
Follow Lauren on Facebook
Follow Lauren on Instagram
- Placed fifth at the 2015 Beach World Championships with Brooke Sweat, duo eliminated by Germany in the quarterfinals
- Won the 2015 AVP Championship with April Ross, their first tournament together
- Name AVP's Best Blocker in 2014
- Finished the 2014 season ranked 23rd on the World Tour and 21st in technical rankings with partner Brooke Sweat
- In the summer of 1998, Fendrick was the kill leader while playing on the U.S. Girls' Youth National Team
- Received her law degree from USC and has passed the bar exam.
- Was a dual sport athlete at UCLA her freshman year, playing softball and volleyball
- Fendrick and Sweat are currently the second ranked U.S. women's team in provisional Olympic ranking points in 15th place (May 30, 2016)
- In 2016 on the FIVB World Tour: 9th at the Rio Grand Slam, Fuzhou Open and 25th at Maceio Open, Vitoria Open, Xiamen Open, Cincinnati Open, Moscow Grand Slam
- Won silver at the 2015 NORCECA Continental Tour Finals with Sweat, their first event back together after a three-month hiatus
- Opened the 2015 FIVB World Tour tying for ninth with Brooke Sweat at the Fuzhou Open in China. Also finished ninth in St. Petersburg
- Placed fifth at the Porec Major in Croatia with Sweat, their best finish of the Tour to that point until also finishing fifth at the Beach World Championships - knocked out in the quarterfinals by Germany 21-18, 21-15. Took their third fifth-place finish in Yokohama and then in Olsztyn, Poland
- Finished 17th in Stavanger, Gstaad, Long Beach and 25th in Moscow. Finished Top 25 in nine of nine events
- Finished fifth with April Ross at the inaugural FIVB World Tour Finals in 2015
- With partner Brooke Sweat, was one of four women's teams to play in Melhores do Mundo, USA vs Brazil in Rio de Janeiro in late February 2015.
- Won the 2015 AVP Championship with April Ross, their first tournament together ever
- In 2014, advanced to Round 3 at the World Series of Beach Volleyball and Stavanger, Round 2 at The Hague Transavia Grand Slam, Shanghai and Moscow all with Brooke Sweat.
- On the AVP Tour in 2014, Fendrick and Sweat finished second in five events and third in one.
- In 2013, Played in 11 FIVB events, the first two with Nicole Branagh, then partnered with Brittany Hochevar. Best finishes were fifth places at Stare Jablonki, Poland, Long Beach, Calif. and Sao Paulo, Brazil with Hochevar. Was second in blocks on the World Tour (1.02 per game). With Hochevar, played in seven AVP events, taking second in Salt Lake City and Huntington Beach and finishing third in four other stops.
- In the final 2012 FIVB event of the season, competed with Nicole Branagh and finished fourth at the Bangsaen Thailand Open. Competed in nine FIVB World Tour events with Brooke Niles (formerly Hanson), just missing qualifying for the second spot on the U.S. Olympic Team.
- Finished the 2012 season in third place among U.S. teams trying to qualify for the Olympic Games. Took second and third at two Jose Cuervo Pro Beach Series events, one each with Brooke Niles and Rachel Scott.
- In 2011, won the Jose Cuervo Pro Beach Series in Miami with Brooke Niles and the first NORCECA event of the season, in the Cayman Islands, and then advanced from the country quota and qualifier to reach the semifinals in the FIVB season opener in Brasilia, where they finished fourth.
- 2010, Lauren and Ashley Ivy competed in six FIVB events with their best finish a 13th in Seoul, Korea. With partner Brooke Hanson, competed in six FIVB events with their best finish ninth in Sanya, China.
- From 2008-09 with partner Ashley Ivy, competed in 12 FIVB World Tour events, best finishes were fourth and fifth in Phuket, Thailand in 09 and 08, respectively. The pair also played in 12 AVP events in 2009.
- 2008, With Ashley Ivy competed in two FIVB Challenger and Satellite events and won both. Lauren and partner Keegan Featherstone finished 13th at the World University Championship in Hamburg, Germany. Partnered with Angela Knopf and Paula Roco for 11 and one AVP events, respectively.
- 2007, Partnered with Claire D'Amore for one FIVB Challenger and Satellite event, finishing 17th.
- In 2004, Lauren partnered with four different athletes through 10 AVP events, including future Olympian Nicole Branagh, whom she finished ninth with at Hermosa Beach.
- Married to beach volleyball player and USC coach Andrew Fuller since 2013.
- Graduated magna cum laude from UCLA in 2003 with a degree in communication studies.
- Received her law degree from USC and has passed the bar exam.
2014-current - Brooke Sweat
2013 – Brittany Hochevar, Nicole Branagh
2012 – Nicole Branagh, Brooke Niles (formerly Hanson), Rachel Scott
2011 – Brooke Hanson
2010 – Brooke Hanson, Ashley Ivy
2009 – Ashley Ivy
2008 – Paula Roca, Angela Knopf
2007 – Holly McPeak, Tammy Leible, Paula Roca, Brittany Hochevar
2006 – Heather Lowe, Tatiana Minello, Pat Keller, Ann Windes, Diane Pascua
2004 – Paula Roca, Nicole Branagh, Ashley Bowles, Daven Allison
2003 – Danalee Bragado-Corso, Julie Romias, Makalani Hovey
Related Links
FIVB New Team = Undefeated Champions
USAV Ross and Fendrick win AVP Championships in first tournament together
Los Angeles Daily News April Ross teams with third partner for record AVP beach volleyball win
USAV Four beach teams on to the quarterfinals at World Champs
Updated May, 2016
4 tips to improve footwork and speed on the sand
Jan. 27, 2016
Top USA beach athletes give tips to improving footwork and speed
Beach teams take short break before 2016 training begins again
Corinne Calabro Nov. 26, 2015
Beach teams will begin 2016 training in December, begin FIVB World Tour in January
Beach Update: Beach finishes 2015 season at NORCECA Continental Finals
Corinne Calabro Nov. 16, 2015
Top beach teams will finish 2015 schedule at NORCECA finals in Tobago
Four U.S. Teams Gear Up For FIVB World Tour Finals In Florida
Scott Alan Salomon Sept. 28, 2015
The event offers $100,000 to each winning team - the highest prize in international beach volleyball history.
Behind the scenes with the USA athletes at USAvBRA
March 06, 2015
USA beach athletes share their experience playing on Copacabana Beach and their time in Rio de Janeiro
Follow the USA vs Brazil event
Feb. 23, 2015
Follow USA Volleyball and the beach athletes in Rio de Janeiro, Feb. 26-March 1
Top USA beach names to face off against Brazil
Feb. 02, 2015
The top USA and Brazil beach pairs will play in a team challenge in Rio de Janeiro this February
Best Photos of 2014
Dec. 11, 2014
The best photos of 2014, featuring Matt Anderson, Jake Gibb, Kim Hill, Kelsey Robinson and more.
Ross, Gibb are MVPs at AVP Awards
BJ Evans Nov. 19, 2014
Off the Court: With Lauren Fendrick
Tyson Rodgers Nov. 17, 2014
Related Articles
More Stories ›


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Archive - Apr 21, 2013 - News / NCAA Daily
Three-star point guard Shane Rector commits to MU
On Sun, 04/21/2013 - 11:43am.
The Kansas City Star/Terez A. Paylor
Related Players:
Grange on Hoop Summit: Wiggins has work to do
On Sun, 04/21/2013 - 11:41am.
Sportsnet.ca/Michael Grange
Related Players:
Cautious Magic won't rule out Nerlens Noel
On Sun, 04/21/2013 - 2:28am.
Orlando Sentinel/Brian Schmitz
Related Players:
USA Falls To World Team 112-98 In 2013 Nike Hoop Summit
On Sun, 04/21/2013 - 2:13am.
USA Basketball
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AICArkansas" to 40404
To receive Twitter updates from the AICA by text message, text "Follow AICArkansas" to 40404
The purpose of the American Indian Center of Arkansas is to make a positive difference in the Native American population of Arkansas primarily by providing services and partnerships that offer education, welfare, and
employment services while striving to promote a fuller awareness of the benefits and services available by entitlement to eligible persons and encouraging the education of all to the history and current situation of Native Americans in the state of Arkansas.
Check us out on LinkedIn!
Use the pages on the left to find the information you need, and if you still have questions feel free to use the "Contact Us" phone number and email. For help with your job search, go to the "Career Paths" page. To apply for services from the AICA, please download the application from the "Application and Forms" page.
The American Indian Center of Arkansas is doing it's best to promote the interests of American Indians in this state and offer as many helpful services as possible. The AICA is a Section 166 funded organization through the Workforce Innovations and Opportunities Act. This means that our main focus is to provide workforce development and training programs for American Indians in the state of Arkansas. We would also be happy to steer you towards partner organizations that may help you with your goals.
The AICA is a non-profit organization which needs your help to continue to provide these life-changing services to those in need; please, donate any amount you can on our "Donate" page.
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Industry Bulletin | December 24, 2012
Rocky Hill town council will meet behind closed doors with its attorney to determine what steps can be taken, if any, to prevent the opening of a state- sanctioned nursing home for prisoners and the mentally ill. Mayor Anthony LaRosa and three members of the council met Monday in town hall with top state officials and representatives of the iCare Management nursing home chain to discuss the pending opening of the 95-bed facility. The state has said it hopes to have the facility licensed and operating in February.
Contact information: Anthony LaRosa, Mayor, Town of Rocky Hill, Connecticut, 761 Old Main Street, Rocky Hill, CT 06067; 860.258.2700; E-mail: firstname.lastname@example.com; Web Site: www.rockyhillct.gov
OPEN MINDS is going green in May for Mental Health Awareness Month


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After raising railway fares last month and mulling another round of fare hike in the upcoming Rail Budget, the rail ministry is expecting a larger-than-usual helping hand from the government this Budget.
The Railways is betting on its efforts at internal resource generation and stripping down its expenses to work in its favour when it comes to budgetary support from the government.
Sources said there are indications that, unlike last year, the Gross Budgetary Support (GBS) from the finance ministry may not be too far from the requested Rs 38,000 crore.
It is learnt that the GBS could hover between Rs 8,000-10,000 crore, more than last years Rs 24,000 crore when the original demand was for Rs 45,000 crore.
The railway ministry is also likely to seek from the Centre an additional corpus fund for critical safety upgrade a fund it last received during former railway minister Nitish Kumars tenure.
Sources said that a few months after setting out to work towards a plan holiday in terms of new works for the next fiscal, Railways has actually managed to strip down its works programme for the next financial year. This, sources say, could work in Railways favour.
Most zonal railways have not proposed new works for next year. Sources said the size of the works programme could be as low as one-fifth of what is considered usual in rail budgets.
Works like laying of loops to increase throughput especially vis-à-vis freight traffic are likely to be on the cards. A number of new lines, especially last-mile connectivity projects are expected to feature in the Rail Budget next week.
In terms of new trains, for instance, even though most railway divisions along the busy 19,000 km trunk routes have been advising railways against introduction of new trains citing traffic congestion, a few new trains are on the cards, sources said. However, the total number is likely to be less than last years.
The Planning Commission has been urging Railways to increase internal funds generation by way of increasing fares, and also consolidate its works programme by sifting out a large number old works to lower the financial burden on its books.


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Nordic buyout firm Segulah has agreed to sell portfolio business Medstop Group Holding to Oriola-KD Holding Sverige AB, valuing it at SEK1.46bn ($226.7m).
The business, which has 65 pharmacies across Sweden, posted EBITDA of SEK99m on sales of SEK2.3bn in 2012. Its share of the Swedish pharmacy market is currently 7.5 per cent.
Segulah acquired Medstop as part of the privatization of the former pharmacy monopoly Apoteket AB in 2010.
Peter Elving, Segulah industrial partner, said, "We are very pleased with this transaction which will allow Medstop – with its excellent and well-managed pharmacies, systems and infrastructure – to grow and prosper with the support of the Nordic region's largest fully integrated pharmaceutical distribution company.
"I am convinced that Oriola-KD will be a good, long-term owner."
Back in January Segulah-backed concrete products maker S:t Eriks bought granite and natural stone supplier Stenia.
Copyright © 2013 AltAssets


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Oscars App Lets You Feel Like You're Backstage with the Stars!carolyncastiglia
A big thanks to Disney for sponsoring this campaign. Click here to see more of the discussion.
If you've got an Android phone, iPhone or Kindle, download the Official Oscars® App and get ready for this Sunday night's big show! Not only does the app give you exclusive content like backstage interviews with your favorite actors (Meryl Streep! Daniel Day-Lewis! Hugh Jackman! OMGIjustpassedout), you'll get Oscar party tips, red carpet fashion extras, video of rehearsal and – most importantly for a lot of you, I'm sure – a chance to pick winners with your Facebook friends! (There's an online version of "My Picks" as well.) A friend of mine runs an Oscar pool every year, but she just had a baby and is putting the finishing touches on her first book so she can't do the pool this year, so "My Picks" should do nicely in her stead for those of us who would otherwise miss out.
My 7-year-old loves watching awards shows with me, but this year is the first year she'll have seen any of the films being honored at The Oscars besides those in the animated feature category, so she'll be psyched to check out the special interviews with the stars of her current cinematic obsession, Les Miserables. Can't wait to see who wins!
Go here now to download the FREE app, and don't forget to watch The Oscars Sunday night, February 24th starting at 7 pm EST on ABC! I'll be live-tweeting the live show, so follow me on Twitter for jokes and genuine joy when my favorites win gold!


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Senior Research Executive - NPD
- Recruiter
- Elizabeth Norman International
- Location
- London
- Salary
- £27000 - £30000 Per Annum
- Posted
- 21 Jan 2013
- Closes
- 18 Feb 2013
- Ref
- Contact
- Recruitment Team
- Business Type
- Agency, In-house / Client-side
- Specialism
- Research
- Contract Type
- Permanent
- Hours
- Full Time
Senior Research Executive
An exciting opportunity has arisen within a fast growing top 20 research and insights consultancy with an excellent client list covering FMCG, finance, leisure, health and beauty as well as retail.
My client is looking to recruit a Senior Research Executive. Having consistently been nominated for best agency awards as well as having recognition for innovation and creativity this consultant really is going places. Working closely with the AD and RD the SRE will be responsible for ad-hoc and continuous projects for a number of accounts. With excellent variety as SRE you will work across a miss of NPD, brand and ad tracking.
The key responsibilities of the Senior Research Executive will include;
- Building strong client relationships, focusing on their business needs.
- Project manage from set up to delivery with minimum input from AD
- Produce and deliver engaging presentations to clients with clear objects for the client to move forwards
- working closely with internal field and data processing departments, ensuring projects are delivered to a high standard and on time.
The attributes of the Senior Research Executive are;
- Client management skills, compelling presenter and pro active
- Project management skills
- Research knowledge – establish quant skills
- Experience from ideally brands and comms or NPD
- Produce creative and meaningful analyses
- Genuine interest in brands, products and advertising with a desire to make a difference
If this role sounds like you then click APPLY NOW!!


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See All Contributors »
So I'm sitting here looking at my schedule for fall semester, does anyone have a favorite professor (either at ISU or anywhere else) and a story to possibly go with why they are your favorite professor?
Ken Kruempel because of SUPERNODES!
Ken Kruempel - Rofflehaus
In all seriousness, Dr. Kruempel was a really great professor and his class is really the first one that made me buckle down and actually work through a class and made me understand what I was working on.
He may be anal but he makes engineers pay much much more attention to the details
Professor Paul Hollenbach/Religious studies.
Wonderful human being. Sadly...he developed Alzheimers later in life and I am pretty sure he has sinced passed away.
A caring individual.
I took a EE class for non EE majors taught by some guy that kind of looked like a muppet. I think his name was Bartlett, or Barret, or something. He talked about music a lot, and speakers, and all the engineering related to that, and somewhere about halfway through the semeseter he threw out the engineering. He said we weren't doube E's, so we'd never need that stuff anyway and instead he talked about interviewing skills, how to answer certain questions that all interviewers asked, how to negotiate job offers, etc. Turned out to be one of the most important classes I took at ISU.
By the way, during the Engineering portion of this class, I don't think anyone ever scored above 50% on his tests. Man they were hard. The nice thing was, the last day of class he called people up individually to show them their grade in his book. I went up and he pointed to the B next to my name. I kind of sighed and said "ok" and he said, "Hang on, how's this" and he erased the B and penciled in an A.
Last edited by ColoradoClone; 06-12-2008 at 09:18 AM.
Fred Haan
I think the class was Aero 161 or something along those lines (was 5 years ago). Suddenly, in the middle of lecture he starts to sniff and asks, "Do you guys smell something?" We all are looking at eachother like, "Well, it is Gilman, so we always smell something". He continues, "No i seriously smell something". He walks into the hall and comes back with cookies for the class.
Or another story with him was opening day for the Cubs he did an entire lecture with his baseball glove on. Didn't mention anything about, just did the lecture with his glove.
Last edited by dmcbrady; 06-12-2008 at 10:06 AM.
Eric Northway, Religious Studies. I took 205: Intro to World Religions as an elective because I thought it would be interesting. It was! I also learned a lot and Northway made the class entertaining and very enjoyable (not to mention, easy). I liked it so much I took 210: World Religion in America in the summer from him and had the same experience. Great guy!
David Stuart - History of Rock n Roll, etc. Awesome teacher and a good friend
Kathleen Waggoner - Law & Politics & American Judicial Practices. Great Teacher and thought provoking subject matter. She could be a little intimidating to speak to initially, especially with that contraption on her hand and arm, but she was one of my favorite professors there.
Steffan Schmidt - Great guy, Great Educator
Last edited by Cybone; 06-12-2008 at 09:23 AM.
Kevin Scheibe in MIS.
Belknap--Phil 230--the guy tutored death row inmates in Nebraska while he worked on one of his degrees, and had some awesome stories about it. It was the first class that I actually wanted to attend everyday and I hated missing because I knew I'd miss a example that makes things "click" or a good story.
Curtis--Acct 215--former mayor of Ames, lost a finger to a lawn mower, loved going to his class. Had no interest in law beforehand but now I just want to know more.
I think I will split the honor between Dr. Apt and Dr. K. G. Madison.
Dr. Apt, (who taught military history at ISU) until he was taken from us, was the most enthusiastic lecturer I've EVER heard speak. And there was never a class that he "just mailed in".
I remember listening to him with rapt attention, as he got more and more worked up over the topic of the day. He just had "it".
Dr. K.G. Madison taught medieval history, and had a personable manner that was hard to beat. I was an awful writer, until he sat me down in his office once, and in a 30 minute session, taught me all one needed to know in how to write a paper.
After that one lesson, I blossomed into a good writer.
I'm baaack! See my Hot Milk For Breakfast blog under Social Groups for more details
Originally Posted by clone2011
Belknap--Phil 230--the guy tutored death row inmates in Nebraska while he worked on one of his degrees, and had some awesome stories about it. It was the first class that I actually wanted to attend everyday and I hated missing because I knew I'd miss a example that makes things "click" or a good story.
Curtis--Acct 215--former mayor of Ames, lost a finger to a lawn mower, loved going to his class. Had no interest in law beforehand but now I just want to know more.
Sweet! Have him this semester for Acct 215
Originally Posted by Cybone
David Stuart - History of Rock n Roll, etc.
Kathleen Waggoner - Law & Politics & American Judicial Practices. Great Teacher and thought provoking subject matter.
Steffan Schmidt - Great guy, Great Educator
I LOVED his Poli Sci 215 class. He was really funny and had tons of information. I loved it when he would break into a story and start yelling in spanish. Great class and great prof.
Dr. Charles T. Wright, Computer Engineering. Explained interrupts with a parable about his wife making him a sandwich. Sadly he died in a car accident near Eldora in 2000 my senior year at ISU.
ISU - Professor Wilsey, Biology. He was just a funny guy (not intentionally), but didn't seem to care. Somehow knew my name by the end of the class (class size of 250).
Iowa - Professor Holstein, Judeo-Christian studies. Profiles - Jay Holstein - fyi - December 11, 2006 - The University of Iowa
Probably the best professor in terms of keeping the interest of the class. He was just amazing at getting people to come back - even though what he was teaching isn't particularly interesting to most.
The artist formerly known as SouthernHawk
Originally Posted by gogagig
Kevin Scheibe in MIS.
agreed...this guy was rather funny.
Respectable guy, and i think i might have actually learned something in his class........compared to other MIS courses.
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TUSA RS-860 Regulator
The balanced piston R-800 first stage is compact and lightweight. It has a full complement of four low-pressure and two high-pressure ports and is fine- tuned for optimum performance.
The S-60 second stage features a diver adjustable sensitivity control to deliver air smoothly with each breath. The surface position decreases the likelihood of a free flow. In the dive position the control allows the regulator to power assist the diver as they breathe using the venturi effect. The S-60 is also equipped with an ortho-consciously designed mouthpiece to increase comfort and reduce jaw fatigue.
The RS-860 is available in both INT (yoke) and DIN versions.
First stage (R-800)
> Compact and reliable balanced piston first stage
> Instant delivery of air and high airflow for superior performance
> Two H.P. ports and four L.P. ports
> DIN version available as RS-860 DIN (300bar/4350psi)
> Eligible for TUSA CARE Free Parts for Life Program
Second stage (S-60)
> Lightweight compact case design
> Venturi breathing adjustment lever
> Left or right hose layout
> Ortho-consciously designed mouthpiece
> Eligible for TUSA CARE Free Parts for Life Program
Venturi Flow Adjustment
The venturi flow adjustment allows for ease of breathing by controlling the direction of air through the mouthpiece.
Ortho-conscious Mouth Piece
The ortho-conscious mouth piece feature prevents jaw fatigue. The ridges and flexible material allow the diver to have more control of the mouth piece and reduces tension in the jaw.
Cold Water Ready
The cold water ready feature enables the diver to use the regulator in water temperatures below 50°F/10°C.
Advanced Flow System
The advanced flow system allows ease of air flow and makes air delivery smoother due to the curved housing structure.
TUSA Regulators are BALANCED PISTON and BALANCED DIAPHRAGM type SINGLE HOSE REGULATORS.
The regulator reduces high pressure air from the scuba
cylinder to ambient pressure suitable for breathing, through the operation of fi rst and
second stage regulators. The first stage regulator reduces incoming high pressure
air, to an intermediate pressure of approximately 135PSI ( 9.5bar). The second
stage regulator, using a diaphragm operated demand valve, further reduces air from
intermediate pressure to ambient pressure permitting normal breathing. The fi rst and
second stages of the regulator are connected by a low pressure hose. A swivel yoke
(TYPE INT) on the fi rst stage body secures the regulator to the cylinder valve, while
an O-ring surrounding the outlet orifi ce on the cylinder valve ensures an airtight connection to the fi rst stage.
Do not attempt to connect low pressure hoses to the high pressure ports with the use
of an adapter. Improper connection will cause damage to the equipment and could
result in serious personal injury. Low pressure components are not intended to
withstand pressures greater than 28Bar ≒(400 PSI). When installing your accessory
hoses, avoid damaging the O-ring. Tighten gently, but firmly into the first stage housing.
SCUBA complying with EN 250 are not intended for more than one user to breathe from
at the same time.
If SCUBA are configured and used by more than one diver at the same time, then the
cold water and breathing performances may not fulfil the requirements of EN 250.
1. Position the tank valve so the outlet points toward the diver.
2. Remove the dust cap from the first stage inlet and place the yoke (or DIN adaptor)
in the center of the cylinder valve connection.
3. Position the first stage body so that the second stage hose goes over the right
shoulder of the diver.
4. Hand-tighten the yoke screw or DIN adoptorscrew.
5. Check all the hose connections to the first and second stages. If they can be
loosened by hand, they should be tightened with a wrench before pressurizing.
6. Check the submersible pressure gauge to make sure it indicates zero pressure.
7. Open the tank valve slowly to gradually allow air into the regulator.
NOTE: During this operation, depress the second stage purge button to reduce
shock to the valve mechanism. Do not perform this operation in a cold environment
below 10°C (50°F). Performing this in a cold environment may cause "freeze-up" of
the regulator which can render it inoperable. If this occurs, you should contact a
TUSA authorized service center.
8. Check the submersible pressure gauge to ensure that it indicates the proper tank
pressure.- 23 -
9. Check the tank/regulator connection for leakage. If leakage exists, it may be caused
by incorrect mounting of the regulator on the tank valve, or by a damaged O-ring in
the tank valve.
10. To confirm that the regulator delivers air properly, first exhale through the
mouthpiece to blow any foreign matter out of the second stage, then inhale. A few
of these breathing cycles should immediately indicate proper function.
11. If you are using the second stage as an Octopus regulator, it is strongly recommended to utilize an Octopus plug to prevent any foreign matter from entering the
second stage through the mouthpiece.
12. When the second stage is not in your mouth, uncontrolled air delivery can take
place. This can be stopped by turning the second stage upside down and allowing
it to fill with water. Should the air delivery continue, abort the dive and have the
regulator inspected by a TUSA Authorized Service Center.
Providing the best possible preventative and routine maintenance before, after, and
between dives will help to ensure the maximum life of your TUSA Regulator. To achieve
this goal, there are a number of simple, yet important, routine maintenance procedures
that should be followed by the diver after each use of the equipment. The following
procedures should be diligently followed in order to obtain the maximum life and
serviceability from your regulator.
1. After each day of diving, the regulator must be cleaned, inspected, and prepared for
the next use, or for storage. As soon as the regulator is removed from the air
cylinder, reinstall the dust cap over the regulator inlet port. This cap is normally
attached to the First Stage and therefore has been under water. Be sure to dry all
the water out of this cap before securing it over the inlet port. Ensure that the O-ring,
if fitted, is in place inside the dust cap.
2. As soon as possible after diving, the regulator should be soaked in warm, not over
50°C (122°F) water to remove salt and mineral deposits.The preferred method is to
attach the regulator to a charged air cylinder, open the cylinder valve, and
thoroughly soak both the first and second stage regulators . Pay particular attention
to directing water into the mainspring cavity of the first stage regulator, the second
stage mouthpiece, and the holes in the second stage cover. Depress the purge
button several times while the regulator is submerged in water. Dry the regulator by
pressing on the purge button with the mouthpiece pointing down. Place the dust cap
in position in the yoke, or over the DIN screw.
Soaking regulator parts in warm water will remove more salt and mineral deposits
than will conventional rinsing. It will loosen deposits on interior components that
rinsing will not (If no charged air cylinder is available, follow the above procedure but
be very careful NOT to depress the purge button, or leave dust cap off, when the
regulator is submerged in water. Failure to do this will allow water to enter both
regulator stages and may result in internal corrosion).
Simply soak the entire exterior of the first stage thoroughly, and proceed as above
when cleaning the second stage.
3. Store in a clean equipment box, or as an alternative, seal inside a plastic bag. Store
in a clean dry place.
4. Lightly lubricate the yoke screw with silicone grease.
5. Never store the regulator while it is still connected to the diving cylinder.
6. Do not use any type of solvent to clean any part of the regulator. Do not expose any
part of the regulator to silicone spray, as some aerosol propellants attack or degrade
rubber and plastic material.
7. Do not carry the diving cylinder by the regulator as such abuse will eventually
damage the regulator or the cylinder valve. Do not expose the regulator to
unnecessary shocks or impact.


text:
PITTSBURGH—An ongoing exhibition capsulizing the 75-year history of the Pittsburgh Steelers' storied professional football franchise is so impressive, Cleveland Browns fans would enjoy it.
Running through Feb. 10, the exhibition, titled "Pittsburgh Steelers 75th Season Celebration: Treasures from the Pro Football Hall of Fame," is at the Senator John Heinz History Center, 1212 Smallman St., Pittsburgh.
The display is featured in the history center's first floor McGuinn Gallery.
Included in the 5,000-square- foot exhibition are Steelers' items from the Pro Football Hall of Fame in Canton, Ohio, the Western Pennsylvania Sports Museum and the Steelers organization.
The exhibit plays to the hearts of history buffs interested in the founding of the team, those still relishing in the glory years of future Hall of Fame inductees and the Steelers of today.
Greeting visitors is a display depicting how founder Art Rooney had purchased the franchise in 1933 for $2,500.
The team was known as the Pittsburgh Pirates until 1940 when a fan contest yielded the Steelers name.
During the first week of the exhibit, visitors could see the bronze busts of all 19 Steeler Hall of Famers.
Marking the first time the busts have been on display outside of the Pro Football Hall of Fame in Canton, Ohio, the "Huddle of Fame" offered a surreal atmosphere of excitement and memories on how much these men contributed to the Steelers and to the National Football League.
During Thanksgiving weekend, Nov. 23-25, all five Steelers' Vince Lombardi Super Bowl Championship trophies were on display.
The coveted trophies rarely travel outside of the team headquarters and are seldom available for up-close viewing.
Another highlight of the exhibit is dedicated to the Dec. 23, 1972, "Immaculate Reception" of then-rookie Franco Harris.
In the American Football Conference division playoff game, the Steelers were trailing the Oakland Raiders by a 7-6 score with 22 seconds remaining in the game. Quarterback Terry Bradshaw took a fourth down snap and threw toward Frenchy Fuqua.
Harris seemingly came out of nowhere and caught a shoe-top level reflected ball and ran it in for the winning score.
A few years later, Harris would visit Three Rivers Stadium while grounds crews were replacing the worn field turf.
Harris asked for the exact section of turf where he made the storybook catch.
That 15-square-foot piece of turf is on display at the exhibit where an on-demand video is available to relive the moment.
In the same area is a section of plate from the stadium elevator where owner Art Rooney was when the famous catch took place. Rooney was on his way to the locker room during the play and did not see it.
He would not learn of the victory until the team stormed into the locker room.


text:
stephtejeda18's Mom Answers Activity
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text:
Hello all!
I´ve changed the zimbra server, and in the new server I have installed zimbra open source and pasted the old /opt/zimbra.
I execute the zmfixperms and when I start zimbra i have this message:
/opt/zimbra/bin/zmlocalconfig: line 53: exec: java: not found
Unable to determine enabled services from ldap.
Unable to determine enabled services. Cache is out of date or doesn't exist.
The new installations start´s well, I try to copy the zmlocalconfig of the new installation to the /opt/zimbra/bin/ restored and i have the same message.
Any idea for what´s happens?


text:
The HIV-HCV Transplantation Transmission Investigation Team. Centers for Disease Control and Prevention: S. Ramachandran, D. Seem, J. Drobeniuc, T. Durant, J. Easton, L. Ganova-Raeva, G. Garcia-Lerma, S. Holmberg, Y. Khudyakov, L. Kumar, Y. Lin, M. Millis, B. Minske, S. Owen, J. Ponterelli, K. Sullivan, W. M. Switzer, A. S. Youngpairoj and G. L. Xia; Gift of Hope Organ and Tissue Donor Network: M. Mozes and A. Smith; Northwestern University Feinberg School of Medicine: E. DeMayo and V. Stosor; Rush University Medical Center: S. Forrest Dodson; University of Chicago Medical Center: E. A. King.
Transmission of Human Immunodeficiency Virus and Hepatitis C Virus From an Organ Donor to Four Transplant Recipients
Version of Record online: 6 JUN 2011
DOI: 10.1111/j.1600-6143.2011.03597.x
©2011 The Authors Journal compilation©2011 The American Society of Transplantation and the American Society of Transplant Surgeons
American Journal of Transplantation
Volume 11, Issue 6, pages 1218–1225, June 2011
Additional Information
How to Cite
Ison, M. G., Llata, E., Conover, C. S., Friedewald, J. J., Gerber, S. I., Grigoryan, A., Heneine, W., Millis, J. M., Simon, D. M., Teo, C.-G., Kuehnert, M. J. and and the HIV-HCV Transplantation Transmission Investigation Team (2011), Transmission of Human Immunodeficiency Virus and Hepatitis C Virus From an Organ Donor to Four Transplant Recipients. American Journal of Transplantation, 11: 1218–1225. doi: 10.1111/j.1600-6143.2011.03597.x
Publication History
- Issue online: 6 JUN 2011
- Version of Record online: 6 JUN 2011
- Received 20 January 2011, revised 8 April 2011 and accepted for publication 11 April 2011
- Abstract
- Article
- References
- Cited By
- Donor-to-host transmission;
- nucleic acid diagnostics
In 2007, a previously uninfected kidney transplant recipient tested positive for human immunodeficiency virus type 1 (HIV) and hepatitis C virus (HCV) infection. Clinical information of the organ donor and the recipients was collected by medical record review. Sera from recipients and donor were tested for serologic and nucleic acid-based markers of HIV and HCV infection, and isolates were compared for genetic relatedness. Routine donor serologic screening for HIV and HCV infection was negative; the donor's only known risk factor for HIV was having sex with another man. Four organs (two kidneys, liver and heart) were transplanted to four recipients. Nucleic acid testing (NAT) of donor sera and posttransplant sera from all recipients were positive for HIV and HCV. HIV nucleotide sequences were indistinguishable between the donor and four recipients, and HCV subgenomic sequences clustered closely together. Two patients subsequently died and the transplanted organs failed in the other two patients. This is the first recognized cotransmission of HIV and HCV from an organ donor to transplant recipients. Routine posttransplant HIV and HCV serological testing and NAT of recipients of organs from donors with suspected risk factors should be considered as routine practice.
alanine aminotransferase
aspartate aminotransferase
centers for disease control
enzyme immunoassay
highly active antiretroviral therapy
human immunodeficiency virus
hepatitis C virus
mycophenolate mofetil
men who have sex with other men
nucleic acid test
organ procurement organization
organ procurement & transplant network
reverse transcriptase polymerase chain reaction
Although organ transplantation has become more successful over time (1,2), infection transmission from donor to recipient remains a risk of organ transplantation (3). Organ donor screening has reduced the risk for human immunodeficiency virus type 1 (HIV) and hepatitis C virus (HCV); however transmission still occurs (3–9). Screening organ donors for HIV became required in 1985 and for HCV in 1992 (4,6–9).
In October 2007, a deceased donor renal transplant recipient who was sero-negative for HIV and HCV pretransplant, tested positive for both viruses 10 months after transplantation. Since the recipient had no identified risk factors for either infection and infection was recognized shortly after transplantation, the case was reported as a potential donor-derived infection as required by current Organ Procurement and Transplant Network (OPTN) policy (10). The state and local health departments were informed, and an investigation was initiated with assistance from the Centers for Disease Control and Prevention (CDC).
Epidemiologic investigation
Medical records of the organ donor and transplant recipients were reviewed to characterize clinical history, including healthcare risk factors for HIV and HCV (e.g. transfusion receipt) and diagnostic test results. For the donor, additional clinical information and social history was collected through interview of his family and known social contacts to elicit behavioral risk factors for HIV and HCV.
Laboratory investigations
Serum or plasma samples of the donor and recipients were tested by the CDC for HIV antibodies using a third generation ELISA immunoassay (Abbott Recombinant HIV 1 + 2, Abbott Laboratories, Abbott Park, IL, USA). Viral RNA was extracted from available specimens and sequences from three HIV viral regions (pol, env and gag) were amplified by reverse transcription polymerase chain reaction (RT-PCR) as previously described (11–13). PCR amplicons were sequenced and phylogenetically analyzed (Figure 1). HIV-1 pol sequences were examined for drug-resistance mutations (see Appendix A) (14).
Sera were tested for anti-HCV IgG using the ORTHO HCV version 3.0 ELISA (Ortho-Clinical Diagnostics Inc., Raritan, NJ, USA). Reactive results were confirmed with supplemental testing using HCV Matrix (Abbott Laboratories) or RIBA 3.0 (Chiron Corporation, Emeryville, CA, USA). Viral RNA was extracted from serum and a segment of HCV NS5b region, encompassing positions 8275–8616, was amplified using real-time nested PCR (15,16). Endpoint limiting-dilution PCR for HVR1 region was done, and its nucleotide sequence determined from single genomes of HCV as described previously (Appendix B) (16). HVR-1-based phylogenetic trees of HCV quasispecies (see Figure 2) were constructed (PHYLIP package, v.3.6, J. Felsenstein, University of Washington, Seattle, WA, USA) (Appendix C).
Blood product traceback
Units of blood products transfused into the organ donor were identified and associated blood donors were contacted for serologic and nucleic acid testing (NAT).
Case definition
We defined a case as HIV and HCV coinfection in a recipient from the same donor in January 2007 who was uninfected by either HIV or HCV before transplantation.
The organ donor was a Mexican-American male in his late 30s who sustained a blunt head trauma due to a motor vehicle accident in January 2007. He was subsequently declared brain dead, and consent was obtained for organ donation. Family members were unable to provide the donor's medical or behavioral history; in the course of his evaluation, a social contact eventually revealed a history of having sex with another man, and he was designated a 'high risk' donor due to this recognized risk factor. It was unknown whether the donor had ever been previously tested for HIV or HCV.
The donor received a total of 20 units of blood products during his hospitalization. Two serum specimens, pre- and posttransfusion, were tested, per protocol, locally by the Organ Procurement Organization (OPO) and were negative for HIV-1/HIV-2 antibody [Abbott HIVAB™ HIV-1/HIV2 [rDNA] enzyme immunoassay (EIA)] and negative for HCV (Abbott HCV EIA 2.0); results of serologic evaluation for cytomegalovirus, Epstein-Barr virus, hepatitis B and syphilis were all negative. The posttransfusion specimens were significantly hemodiluted (Table 1). A pretransfusion specimen was not available for repeat testing as part of the later investigation.
|Anti-HIV antibody
|HIV Viral Load
|Anti-HCV IgG
|HCV Viral Load
|Pretransfusion (Routine screening results)
|Unavailable for testing
|Unavailable for testing
|Unavailable for testing
|Unavailable for testing
|Investigation results
|Investigation results
|(898 IU/mL)
Blood transfusion traceback testing
All 20 individuals who donated the 20 units of blood products received by the donor were identified and tested for HIV and HCV by EIA and RT-PCR and found negative.
Left kidney recipient
The index case-patient was a male in his early 30s with a history of childhood-onset nephrotic syndrome of unknown etiology and failed deceased donor renal transplantation in 1997. He was HIV- and HCV-negative by serology in 2003 as part of his evaluation for his second transplant. He received his second kidney transplant and was given methlyprednisolone, alemtuzumab (30 mg) and a single dose of rituximab (375 mg/m2) for induction, and maintained on tacrolimus, mycophenolate mofetil (MMF) and prednisone. He denied any risk factors for acquiring HIV or HCV other than hemodialysis. Three months following the transplant, routine laboratory testing revealed elevated liver enzymes (aspartate aminotransferase [AST], 414 IU/mL; alanine aminotransferase [ALT], 660 IU/mL and alkaline phosphatase, 202 IU/mL). Serologic test results for infection by hepatitis A, B and C viruses were negative; HCV RNA testing was not performed. Subsequently, a liver biopsy indicated inflammation and stage II/III fibrosis, and HCV RNA (>10 000 000 IU/mL) was detected in serum. Ten months after the transplant, a kidney biopsy showed Banff 1A acute cellular rejection and a proliferative glomerulonephritis, possibly consistent with HIV infection. Serologic testing revealed positivity for HIV 1/2 antibody by EIA and Western blot. HIV viral load was 520 copies/mL and baseline CD4+ cell count was 16/μL. He was subsequently placed on highly active antiretroviral therapy (HAART) consisting of efavirenz, emtricitabine and tenofovir, resulting in a virologic and immunologic response. Given the diagnosis of newly acquired HIV and HCV infection, immunosuppressive therapy, including tacrolimus and MMF, was decreased. The patient's renal function progressively declined, resulting in reinstitution of hemodialysis, transplant nephrectomy and discontinuation of immunosuppressive medications 14 months posttransplant. Anti-HCV IgG was detected shortly after this, and he was started on anti-HCV treatment with peginterferon α-2a and ribavirin with complete and sustained virologic response. He has subsequently been listed for a combined kidney/liver transplant. His spouse tested negative for both HIV and HCV.
Right-kidney recipient
The right-kidney recipient was a young-adult female with a history of renal disease caused by glomerulonephritis. She was transplanted and received daclizumab for induction and was maintained on tacrolimus, mycofenolate mofetil and prednisone. Her pretransplant HIV and HCV serologies had negative results at the time of transplant. Serum drawn 10 months posttransplant tested positive for HIV antibodies by EIA and Western blot. Her HIV viral load was 34 100 copies/mL and CD4+ cell count was 556/μL. Anti-HCV IgG was negative, but HCV RNA was detected at greater than 5 million IU/mL. AST was 43 IU/mL and ALT 50 IU/mL. She was admitted in January 2008 for complications related to organ rejection and was given zidovudine, lamivudine and efavirenz. Continued rejection led to progressive azotemia requiring reinstitution of hemodialysis and transplant nephrectomy at 19 months posttransplant, at which time immunosuppression was discontinued and she was relisted for kidney transplant. She failed to achieve an HCV virologic response (<6 million IU copies/mL) with 16 weeks of treatment with peginterferon α-2a and ribavirin. As of January 2009 the patient remained clinically stable, with normal liver enzyme activities (AST 16 IU/mL and ALT 20 IU/mL). The patient responded virologically and immunologically to HAART; her regimen was changed to lamivudine, tenofovir and efavirenz because of a detectable viral load; as of May 2010, her CD4 count is 880 cells/μL with an HIV viral load <50 copies/mL. She had no contacts who warranted HIV testing.
Liver recipient
The liver recipient was a female in her late 60s with a history of cryptogenic cirrhosis, who underwent liver transplantation; some details of this donor have been previously published (17). She received four doses of methylprednisolone followed by daily tacrolimus and prednisone. Approximately 6 weeks after transplantation, marked allograft dysfunction developed and liver biopsies demonstrated changes consistent with acute cellular rejection with mild lobular hepatitis. Corticosteroid treatment of rejection led to some improvement in liver enzyme elevation, but persisted with hyperbilirubinemia. One month prior to transplantation, HIV and HCV serologic test results were negative and HCV RNA had been undetectable. Eleven months after transplantation, she was serologically positive for HIV, with an HIV viral load was >500 000 copies/mL and CD4 count of 34 cells/mL. Her HCV serologic testing was negative but her HCV viral load was 5 770 000 IU/mL. Antiretroviral therapy consisting of emtricitabine, efavirenz and tenofovir was initiated with virologic response (HIV RNA <400 copies/mL). Anti-HCV therapy was not given. Multiorgan failure developed 389 days after transplantation secondary to biliary sepsis, and the patient expired. She had no contacts who warranted HIV/HCV testing.
Heart recipient
The heart recipient was a male in his early 60s with a history of ischemic cardiomyopathy. He underwent a heart transplant and received basiliximab and thymoglobulin for induction and was maintained on tacrolimus, mycophenolate mofetil and prednisone. HIV and HCV serologic testing, on serum drawn 1 month pretransplant, were negative. In November 2007 he was found to be positive for HIV 1/2 antibody by EIA and Western blot, with an HIV viral load >100 000 copies/mL and a CD4+ count of 48 cells/μL. Anti-HCV IgG was negative, but the HCV viral load was >4 million IU/mL. Serum AST was 43 IU/mL and ALT was 28 IU/mL. He was subsequently placed on therapy with efavirenz, emtricitabine and tenofovir and achieved rapid and sustained virologic and immunologic responses. He was admitted in December 2007 for biopsy-proven moderate acute cellular rejection, which was treated with a course of prednisone. As of August 2009 the HIV viral load remained undetectable, the CD4+ cell count was 50/μL, and HCV viral load remained >4 million copies/mL (AST of 117, ALT of 47). In August 2009, the patient became noncompliant with his medical care and refused subsequent follow-up. He expired of multiorgan failure in November 2009. His spouse tested negative for HIV and HCV.
Laboratory results
HIV testing: Post-transfusion serum obtained from the organ donor tested at CDC was negative for antibodies to HIV; however, HIV RNA was positive by qualitative PCR. There was insufficient residual sample to perform quantitative PCR. All recipients were confirmed positive for HIV antibodies in their posttransplant samples (Table 2). HIV pol sequences from the organ donor and the liver recipient were not amplifiable; pol sequences from the other three recipients failed to show drug-resistance mutations. The gag and env sequences from all five patients were identical except for a single nucleotide difference found in the liver recipient. Phylogenetic analysis showed close clustering of the HIV sequences from all five patients (Figure 1).
|Posttransplant values at initial assessment—November 2007
|Anti-HIV IgG
|Anti-HCV IgG
|Anti-HIV IgG
|HIV Viral Load (copies/mL)
|Anti-HCV IgG
|HCV Viral Load (IU/mL)
|Left kidney
|23 million
|Right kidney
|4–5 million
|5 million
|1 million
|4–5 million
HCV testing; Post-transfusion serum obtained from the organ donor tested at CDC was negative for anti-HCV IgG, but the HCV viral load was 898 IU/mL. The four recipients were negative by HCV serologic testing in all posttransplantation samples but were positive by HCV RT-PCR. HCV RNA from the donor's serum could not be amplified for sequencing analysis, but HCV in sera of all the recipients was genotype 1a. Quasispecies analysis of HCV in recipient samples showed close clustering (Figure 2).
We describe cotransmission of HIV and HCV from an organ donor to four transplant recipients. Genetic sequences were highly related between HIV and HCV strains infecting all four recipients, confirming transmission from a common donor. The donor was 'high risk' by the OPTN definition, due to history of having sex with another man, and was screened according to current OPTN policy (18). However, serologic screening for HIV and HCV yielded negative results, presumably due to sampling during the 'window period' which follows acute HIV and HCV infection, before seroconversion. However, other possibilities for a falsely negative serology result include hemodilution and assay interference from substances in the specimen (5). An aliquot of the donor's pretransfusion blood was available, but this sample could not be accessed for HIV and HCV retesting due to ongoing litigation, thereby limiting the ability to understand the reason for the false-negative results. Transmission through transfusion of the organ donor was excluded through lookback tracing and testing.
Previous reports of viral pathogens transmitted through organ transplantation underscore the potential for unexpected adverse outcomes of transplantation (19–21). Residual risk of disease transmission should be understood since, unlike many tissues used for transplantation, solid organs cannot be processed, disinfected or otherwise modified to inactivate infectious pathogens, and there is no absolute donor exclusion policy based on behavioral risk history. Further, the timeline for donor evaluation and screening must be done within a few hours after declaration of brain death, and the quality of donor medical and social history assessment is often limited. If only the parents had been interviewed, donor risk would not have been identified.
Laboratory assessment of donors includes serological screening for markers of infection (18). Although NATs for HIV and HCV shortens the interval between infection and detection, their use is currently limited by lack of availability, prolonged turnaround times and false-positive results which may delay or prevent transplantation and is not required by current OPTN policy (22).
The risk of disease transmission through organ transplantation must be balanced against the risk of potential recipients dying while waiting for an organ (23). However, due to organ shortage and because organ transplantation often is lifesaving, organs from donors with known elevated risk including men who have sex with other men (MSM) history often are transplanted whenever the benefit of transplantation is considered to outweigh the risk of potential disease transmission (24–28). Risk-benefit may not be the same, however, for all organ types, or for all candidates on the waiting list for a given organ type, emphasizing the need for careful candidate informed consent.
Current OPTN policy requires that when an organ donor is classified as 'increased risk', the recipients must be informed of, and give consent to, the risk in order to be transplanted with organs from that donor; such a policy was not in place at the time of this transmission event (10). Guidelines recommend that recipients of organs from increased-risk donors be tested at 1, 3 and 12 months posttransplantation (5,22). However, many centers have not implemented such screening practices or rely on serologic testing alone which may yield false negative results; as such, routine testing of recipients with assays that directly detect infection, such as NAT, should be considered. None of the recipients involved in this case were screened posttransplantation (29). Improved screening using NAT for recipients of organs from high-risk donors should allow earlier therapeutic intervention and may prevent further disease transmission through quarantine of residual tissue from the same donor, and could have led to recognition of this transmission event earlier (30). This investigation also highlights the importance of NAT for diagnosis of donor-derived HIV and HCV in the setting of immunosuppression. In this disease cluster, all recipients were seronegative but NAT-positive for HCV, and one had an indeterminate HIV western blot; similar results have been found in other unpublished HCV transmissions.
This transmission event also suggests that screening donors with NAT or combined antibody–antigen assays may identify infectious donors missed by serologic testing alone. Existing data suggest that 0.9% of seronegative organ donors have detectable HCV RNA, in part due to the long window period for HCV (31). Further, organs from HCV-infected donors can be safely used in HCV-infected recipients, minimizing the impact of false-positive results on organ availability (32). In contrast, organs from HIV-infected donors cannot be recovered by OPTN policy, and therefore false-positive results of NAT may result in a net loss of usable organs (22). It also is possible, however, that use of NAT may improve organ acceptance from high-risk donors with negative testing results, expanding the donor pool and balancing or exceeding organ discard from false-positive results.
The lack of recognition and real-time communication of recipient status have been common features of many of the clinically significant donor-derived disease transmissions (3,19,21,33). New diagnosis of HCV in our index patient was not considered to be of donor origin until recognition 7 months after the patient's transplantation. Further, although at least two recipients had liver abnormalities that were noted, it was unknown that similar problems existed in other recipients until the investigation began several months later. Testing of other recipients was only conducted after the index case was reported to the OPTN and the public health system; such testing led to recognition of infection of all recipients. Although the OPTN/UNOS Patient Safety System facilitates communication and categorization of potential disease transmissions, through review by the Disease Transmission Advisory Committee, it is currently limited to organ transplantation in an oversight role and does not include public health investigation. Since numerous tissues may be procured from the same individual who donates organs, broader systems, similar to the recently piloted Transplantation Transmission Sentinel Network (TTSN) (34), are needed to facilitate communication and investigation of potential disease transmissions for events involving other tissues, and for those events of public health significance.
In summary, both HIV and HCV were transmitted from an organ donor to four transplant recipients despite routine negative serologic screening. Recognition of recipient infection was delayed by lack of awareness of potential donor-origin of the infection and by reliance on serology instead of including NAT for recipient testing. Standardization of donor risk assessment, use of NAT in donor screening, routine posttransplant testing of recipients for HIV and HCV by serology and NAT of recipients from high-risk donors may help to further improve the outcomes of organ transplantation.
No commercial organization prepared or funded this document. The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation, except for MG Ison who discloses research funding, paid to Northwestern University, by ViraCor and paid consultation by Abbott Molecular, Biogen Idec, and ViraCor. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
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Appendix A
Unequal nucleotide composition and measurement of phylogenetic signal were determined with the likelihood mapping implemented in the TREE-PUZZLE program (35). Sequences were aligned using Clustal W (36), edited manually and all indels were removed. The best fitting evolutionary model for the aligned sequences was determined using a hierarchical likelihood ratio test in the program Modeltest v3.7 (37). A variant of the GTR model, allowing six different substitution rate categories (rAC= 2.50, rAT= 0.87, rGT= 1, rAG= 6.27, rCG= 0.96, rCT= 6.27), with gamma-distributed rate heterogeneity (α= 0.6041) and an estimated proportion of invariable sites (0.3652), was determined to best fit the data. Phylogenetic relatedness of concatenated donor and recipient HIV env (360-bp) and gag (p17; 396-bp) sequences was inferred using Bayesian inference implemented in the BEAST software program (38). These two HIV regions are commonly used in phylogenetic analyses and comparisons of HIV strains in transmission cases (39,40). The Bayesian calculation consisted of two independent 10 000 000 Markov Chain Monte Carlo (MCMC) generations with sampling every 1000th generation. Convergence of the MCMC was assessed by calculating the effective sampling size (ESS) of the runs using the program Tracer available at http://beast.bio.ed.ac.uk/Tracer. All parameter estimates showed significant ESSs (>150). The tree with the maximum product of the posterior clade probabilities (maximum clade credibility tree) was chosen from the posterior distribution of 5000 sampled trees (after burning in the first 5001 sampled trees) with the program TreeAnnotator version 1.4.6 included in the BEAST software package (38). Both the constant coalescent and Yule process were used as tree priors with a relaxed molecular clock model. Trees were viewed and edited using FigTree v1.1.2 available at http://tree.bio.ed.ac.uk/software/figtree. Resistance was determined using the Stanford genotypic resistance interpretation algorithm available at http://hivdb.stanford.edu/pages/algs/HIVdb.html.
Appendix B
At the limiting dilution, the DNA target templates are presumed to be distributed in a Poisson manner, so that 50% of reactions do not carry template molecules, and thus generate no PCR product. Under such conditions, the positive reactions are most likely to have been initiated from a single-template molecule. Multiple, nested real-time PCR amplifications were performed at the endpoint limiting-dilution determined for each specimen, following which about 50–60 positive amplicons were identified using melting peak analysis. All the HVR1 PCR positive products were sequenced. Sequencing reactions were performed using the BigDye v3.1 chemistry sequencing kit (Applied Biosystems, Foster City, CA, USA), and products were sequenced using an automated sequencer (3130xl Genetic Analyzer, Applied Biosystems). Preliminary sequence analysis was conducted using SeqMan and MegAlign programs from the Lasergene DNA & Protein analysis software (version 7.0, DNASTAR Inc., Madison, WI, USA). The Accelrys GCG Package (Genetic Computer Group, version 11.1-UNIX, Accelrys Inc., San Diego, CA, USA) was used for further analysis. Nucleotide sequences were aligned using the GCG multiple alignment program Pileup.
Appendix C
Frequency distributions of pair-wise distances between nucleotide sequences were estimated using the evolution program in the Accelrys GCG Package. Shannon entropy analysis was applied to measure the extent of quasispecies complexity at suboptimal PCR conditions. This entropy measure was calculated as S =–Σ(pi ln pi), which takes into account the frequency of each sequence (pi) in a given set of quasispecies. The entropy value was then normalized as Sn= S/lnN, to take into consideration the total number of quasispecies sequences (N) analyzed during each PCR. SAS for Windows (Version 9.12, SAS Institute Inc., Cary, NC, USA) was used for the comparison of Shannon entropy and genetic distances.


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Home > Lifestyle > People
Thursday, 19 June 2014 | MYT 6:55 PM
by steve hollandandgabriel debenedetti
Pundits are saying that US president wannabe Hillary Clinton is using her 'Hard Choices' book tour to see if Americans are ready — and they're probably right.
The reception Clinton gets is likely to help her decide whether to launch a bid to be elected the first woman US president. So far, polls point to her as the overwhelming favourite for the Democratic presidential nomination should she run.
Clinton says she will make up her mind about a presidential run after congressional elections in November, though many Democrats think she will run. Those close to her say the book tour will help her decide.
Clinton — a woman whose every move, from her hairstyle to her pending status as a grandmother, is watched with an unsparing eye — will use the book tour to shift the conversation to her foreign policy record.
"I think essentially this is to gauge what the reaction is to the book and gauge what the reaction is as she tours the country," said a Clinton associate. The tour allows her to "get her toe in the water without drowning," the associate added.
Hitting shelves in US bookstores on June 12, Clinton's book and the ensuing tour that passes through New York, Chicago, Philadelphia and Washington, puts her in the public spotlight in a more intensive way than at any time since she resigned as secretary of state early in 2013.
Clinton loyalists believe the book will show her to be a foreign policy pragmatist during what she considers to be the most successful period of her political life. Her four years at the State Department were not, however, without controversy, and Clinton is using the tour to defend her record and explain her reasoning behind key decisions.
Of Benghazi and 'linguistic mistakes'
A chapter is devoted to the Sep 11, 2012, attack by militants on a US facility in Benghazi, Libya, in which the US ambassador to Libya was killed. Republicans have accused then-state secretary Clinton of not doing more to ensure the safety of Americans there.
In an ABC interview that aired on June 9, Clinton said she was "ultimately responsible for my people's safety." But pressed on whether there was more she could have done, Clinton said there were limits. "I'm not equipped to sit and look at blueprints, to determine where the blast walls need to be or where the reinforcements need to be," she said. "That's why we hire people who have that expertise."
Republicans are vowing to keep the issue alive, saying it calls into question how she would deal with foreign policy crises as president. "Benghazi is not going away," said Republican strategist Scott Reed.
In the book, Clinton treads a careful path between being a faithful servant to Obama and someone who would chart her own course on the global stage. In what may be an attempt to head off criticism from the left, she disavows her 2002 Senate vote in favour of the Iraq war — a vote Obama used effectively against Clinton in defeating her for the nomination in 2008.
In the book, Clinton also defends her much-criticised 'reset' in US-Russian relations as a linguistic mistake, an episode that is all the more glaring now with Russia's incursion into Ukraine and Washington-Moscow ties at their lowest ebb since the Cold War.
Clinton says she differed with Obama on deciding not to arm Syrian rebels. She is sceptical about negotiations with the Taliban, a move that gives her some distance from uncomfortable questions regarding Obama's recent swap of five high-value Taliban prisoners for Army Sgt Bowe Bergdahl.
In the book, she wrote: "I acknowledged, as I had many times before, that opening the door to negotiations with the Taliban would be hard to swallow for many Americans after so many years of war."
Flying shoe
For some, it's hard enough to lob footwear at the former first lady. In April, while addressing the audience at an event in Mandalay Bay Hotel in Las Vegas, Clinton was caught on video dodging a flying shoe. "Is that somebody throwing something at me? Is that part of Cirque du Soleil?" Clinton reacted. "Thank goodness she didn't play softball like I did."
The shoe thrower, Alison Michelle Ernst, who was charged with evading security and assault, is currently undergoing a judge-ordered competency evalutation to decide whether or not she was mentally sane when she hurled the soccer shoe and several papers at Clinton.
Regardless of brickbats and flying shoes, Clinton is a woman determined, and the book may just be the deal-breaker.
Not even Republican accusations that the princely sums she's been receiving for public appearances – she is speculated to have been paid up to US$250,000 (RM807,866) for a recent speaking engagement with trade groups in Chicago – is placing her "out of touch" with working class Americans have done much to derail her from the end goal.
"It's a campaign book, but what she is trying to do is set the record straight, then move on to other things. So that's why it's coming out now," said Keith Urbahn, a book agent for conservatives. The book tour recalls Clinton's 'listening tour' of New York state, which she conducted before deciding to run for a New York Senate seat in 2000, an election she won.
"I am convinced that she has already decided to run and that she will run and that she will be the nominee. I think this is just the first phase of the process," said Democratic strategist Bob Shrum, who advised John Kerry on his 2004 presidential run.
But can Clinton convince the rest of America that she's not a 'hard choice'? That remains to be seen. – Reuters
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Dancing with the Stars 7 — Who Will Win?
I am picking Brooke Burke to win this season's Dancing with the Stars. She has been the most consistent, and the judges love her to death. It would take a total meltdown tonight from Brooke Burke for either Lance Bass or Warren Sapp to take the mirrorball trophy out of her hands on Tuesday. Her win would also set up a bit of a rivalry between the show's young male dancers: Mark Ballas and Derek Hough — similar to the rivalry between 2-time champions Cheryl Burke and Julianne Hough.
However, this season kinda reminds me of season 5 when Helio Castroneves and Julianne Hough pulled off the upset vs. Mel B & Maksim Chmerkovskiy. We already had a "runaway" winner last year with Kristi Yamaguchi — it's very possible that the show could mix things up on the last night of the season.
Go Lance and Lacey!!! For the upset win!!!
Watch Dancing with the Stars with me tonight on Rickey TV


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God at Work: How Faith and the Marketplace Intersect
with Dr. David W. Miller
Princeton University Professor and Director of the Faith and Work Initiative at Princeton
Dr. Miller sits down with Dean Turney Stevens to talk about ethics in business, the intersection of faith and work in our lives today, and why he decided to leave a successful investment banking career in London to focus on teaching students and executives about doing the right things.
David W. Miller, Ph.D.
David Miller serves as the Director of the Princeton University Faith and Work Initiative. His academic appointment is Associate Research Scholar and Lecturer. Prior to coming to Princeton, he was at Yale University for five years, where he served as the Executive Director of the Yale Center for Faith & Culture, and taught at both the Yale School of Management and Yale Divinity School. David's signature course is: "Business Ethics: Succeeding Without Selling Your Soul."
David brings an unusual "bilingual" perspective to the academic world, having spent 16 years in senior executive positions in international business and finance. Prior to academia, David lived and worked in London, England for eight years, where he was a partner in a private equity firm that specialized in international investment management, corporate finance, and mergers and acquisitions. Before that, he was a senior executive and director of the securities services and global custody division of HSBC Group.
After his corporate experience, he entered academia, receiving his M.Div. and Ph.D. in ethics from Princeton Theological Seminary. While doing his doctoral work in ethics, David began working with CEOs and senior executives in his capacity as president and co-founder of the Avodah Institute. He continues in this role today.
In addition to his research, writing and teaching, David serves as an advisor to several corporate CEOs and senior executives on questions pertaining to ethics, leadership, and the role of faith at work. He is a frequent speaker at gatherings of business leaders, corporate events, and academic conferences. His views are often cited in the media, including in the New York Times, Wall Street Journal, Fortune Magazine, radio and the major television networks.
David's book, God at Work: the History and Promise of the Faith at Work Movement (Oxford University Press, 2007) challenges business academics and executives, as well as theologians and clergy to think differently about ethics, faith and work.
Miller spoke at the Dean Institute's annual fundraising dinner in Nashville on November 1, 2010 and appeared on the Lipscomb University campus at several student and academic events. At this event, Jack O. Bovender, retired chairman and CEO of Hospital Corporation of America (HCA), received the first annual Dean Institute award for his leadership in creating a culture of high integrity at HCA. More than 150 invited guests attended the dinner at the Frist Center for the Arts.


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