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Amazon fires away at Google by rolling out cloud music player
Internet retail superpower Amazon (AMZN) is gunning for Google (GOOG) and its place as the top provider of Android app services. Just about a week after rolling out its new Amazon Appstore that sells apps for Android devices, Amazon has rolled out a new cloud music service that works on PCs and Android devices.
Amazon's Cloud Player works by allowing users to upload their music to Amazon's servers from a PC or Mac that's linked to an Amazon account. Once that's done, the music can be streamed from Amazon over an Internet connection to any supported device, for free. That means PCs and Macs can receive and play the music, as well as Android phones and tablets – Amazon has added the cloud player on its Android MP3 app, so anything uploaded to the Amazon cloud can be played right away.
Users start with some free server space – 5GB, to be exact – that can be used to upload MP3 and AAC music files. Buying an album of MP3s from Amazon's music service automatically bumps that storage quota to 20GB, with the Amazon MP3s
That's a boon to Android users, who can use the service right away without any cost. It demonstrates a big push from Amazon to take a chunk of the mobile market for Android away from Google. The Android Market that Google created is coming along, but it's still far from being as solid as Apple's (AAPL) iTunes App Store, and that can push users and developers alike to adapt the Apple system. The Android Market has problems with helping users find apps and stopping developers from stealing from one another, and while Apple has some similar issues, its control and iTunes ecosystem mitigate a lot of the problems that Google continues to struggle with.
Enter Amazon, which has a new Android app store to compete with Google and has already garnered some big exclusive deals for its store. Most notably is Angry Birds Rio, the latest iteration of Rovio Mobile's gaming phenomenon, which ties in with the upcoming Fox animated movie Rio. Amazon has grabbed other exclusives along the way, and is leveraging its substantial retail infrastructure to help it compete in the app space.
To the cloud!
And then there's the Cloud Player, a service with which neither Google nor Apple has anything to compete. That gives Amazon even more power – right now, the Cloud Player doesn't support iOS devices through their Mobile Safari web browser (and it seems no other available browsers in the App Store work with the Cloud Player, either). That means Amazon has effectively locked out Apple users from the service; whether the company eventually allows iOS to access the Cloud Player is up to Amazon, and it could cost iDevice owners when they could get the service for free.
Google and Apple are both (supposedly) working on cloud music services of their own. We've been hearing rumors that Google is priming to roll out its own music service, similar to what it recently did with e-books. Reportedly, Google was struggling with what Amazon seems to have overcome: the battle with record companies over storing things digitally in the cloud. Apple's side may be stalled by the desire to incorporate video streaming into its service, or by technical considerations that are going with the big server farm (at the cost of $1 billion) it recently built to reportedly be the backbone of its coming cloud services.
Regardless of what the other two companies are up to, there's one big glaring fact that remains: Amazon has cloud-based music, Google and Apple don't.
It's clear that Amazon has a real battle plan for Android and the mobile space, and it's rolling it out blitzkrieg-style. The company is firing away with both barrels and providing services to the mobile space that just aren't available anywhere else.


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Why can't we send referees to the penalty box? Two minutes for unsportsmanlike conduct? Seriously, can the powers that be think about it? I've never been all that concerned about beer-league refereeing, in my 16 years of playing at UBC … Continue reading
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The 10 O'Clock: DiPietro happily takes $1.5 million a year through 2029, plus a roster spot with the Charlotte Checkers
Weekend Warmup: Five sporting events to watch this weekend
Yes, you know the Canucks are playing the New Jersey Devils on Friday (SNP, TEAM 1040, 4 p.m.) and the Dallas Stars on Sunday (SNP, TEAM 1040, noon). But that's not what the Weekend Warmup is about. The WW points … Continue reading

subset: commoncrawl


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.- In an emotion filled ceremony this weekend Archbishop Kazimierz Nycz was formally installed as the new Roman Catholic Archbishop of Warsaw. Nycz took the helm of the archdiocese following a scandal which saw several Polish clerics admit to having succumbed to pressure to cooperate with the formerly ruling Communist regime.
At the Palm Sunday ceremony Archbishop Nycz urged Catholics not to "betray the Christian roots of Europe, the Christian concept of life from conception to natural death, the Christian understanding of marriage and family, freedom in raising children and everything which is human dignity," according to the German Press Agency (DPA).
The archbishop also said his priorities will include establishing good relations among the clergy, with lay people and creating more open contacts with the young. He stressed that in a modern pluralistic society the Church cannot fulfill its mission without the lay. He added, he would welcome the faithful to address expectations with regard to his performance in duties.
Pope Benedict XVI appointed Nycz on March 3 on the heels of a scandal which erupted in January when Archbishop Stanislaw Wielgus dramatically backed out of assuming the post over allegations he had co-operated with communist-era secret police.
Nycz, 57, was recently identified in a new book, 'Priests and the Security Police,' as being a clergyman of outstanding fortitude who did not succumb to pressure to co-operate with communist intelligence services, the DPA reported.
Nycz holds a doctorate in theology and carries the reputation of being humble and an open and effective communicator. He also played a pivotal role in organising visits of the late Pope John Paul II to his Polish homeland.


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Today's Deals:【Beeconomic】 IPL Hair Removal and Whitening for Underarms: One Session (P480), Six Sessions (P2400), or Unlimited Sessions until December 31, 2013 (P3840) at Vergutz Medical Spa (Up to P48000 value)
VOUCHER RULES Groupon is valid from April 22 – December 31, 2013 Failure to redeem Groupon within validity period will render Groupon invalid No refunds for unused sessions Limit 1 Groupon per person per day May purchase multiple Groupons and may be given as gifts Sessions are non-transferable and should be consumed by 1 person only Results of treatment may vary from person to person Arrive at least 15 minutes before appointment Please expect a high demand for weekend bookings. It is recommended to book well in advance Visits must be 2 weeks apart REDEMPTION DETAILS Groupon printed vouchers are strictly required upon redemption Groupons may be redeemed at: Californian Bloom, Rm. D. VNU Arcade, Cebu North Road, Paknaan, Mandaue City, Cebu Valid only at the branch indicated on the voucher Reservation is strictly required; call 2-3 days in advance: +632.421.1918 / +63917.863.9968 Provide the following information upon making your reservation: Full name Contact details Voucher Code Security Code Date and time of reservation RESTRICTIONS Walk-ins will not be entertained Reschedules are subject to availability Cancellation on the day of reservation / no-show shall forfeit the voucher Operating hours: Monday – Saturday, 10:00am – 9:00pm Vouchers are not valid for use on special occasions and public holidays Offer does not apply on group event bookings Vouchers cannot be used in conjunction with senior citizen card, or any other promotion Bring valid IDs / Goverment issued ID All paid transactions are non-refundable No cash back or credit for any unused amount See the rules that apply to all deals


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TV: John's Mandela magic
by Stuart Vose
Defender recalls meeting ahead of Nelson Mandela Day.
Saturday's game against Manchester United is Nelson Mandela Day at the Stadium of Light - and John O'Shea is lucky enough to have met the man himself.
Log on to SAFC TV now to watch O'Shea talking about going face-to-face with the former South African president and the club's work with the Nelson Mandela Foundation.


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"We still do it like we supposed to – Street Certified" is the chant heard throughout M.O.P.'s new track with Mobb Deep.
With M.O.P. currently working on an album (one of the contributors includes DJ Premier), a new track was bound to be released. What better way to resurface than to release a track with another legendary group from NYC, Mobb Deep. M.O.P.'s Billy Danze and Lil' Fame and Mobb Deep's Prodigy and Havoc each spit aggressively over the track's menacing production. "Street Certified" was premiered by DJ Whoo Kid on Shade 45 earlier this week so forgive the radio rip, an official single should make its way to soundcloud and audiomack soon.
M.O.P. isn't the only group making a comeback. Mobb Deep also dropped the first taste of their album, The Infamous Mobb Deep, late last week. 2014 is starting to look good for fans of both groups.


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Nov. 5, 2005
Recap | Final Stats | Notes
WSU Head Coach Bill Doba
"Our kids battled their butt off. They gave it everything they had . I thought they played decent in the second half, better than we have been playing. I took points off, I had confidence in that offense. It looked like it had just a yard, I was told it was a yard, I thought sure we could make it. I felt at the time the wind was blowing, if we took the field goal and three points, then we are kicking into the wind and the score is tied, we were having trouble stopping those guys and if they are throwing the football going down the field, I just wanted to win with these guys and give them a chance to win and I thought a tie at the time they go down and kick a field goal and then we are behind again with the wind in our face. The kid kicked two great ones, I thought they were threw, but they were both just a little left. Tough loss for our kids.
(Hesitation on not kicking field goal) I thought about it long and hard. They way we were moving the ball and running the ball I thought surely we could get a yard. That is the play we worked on all week. It was a toss. It was our goal line play. We put the heavy people in to run it and they just didn't execute well enough.
(Momentum at that time) I just thought we would get a yard and a touchdown we would be up by four. It is tough enough kicking into that wind. If you gave them a short field, a couple of first downs, they kick a field goal and you are down three again.
(Realization No Bowl) They were not real happy. I imagine it set in, I think they realize that.
(Taken points off before) I don't remember, I really don't know if I have or not.
(Defense got ball back) If it was tied, they would be throwing the football. They were just running the ball to kill the clock. So it would have been an entirely different game. You can't second guess. They would have had an entirely different philosophy coming out after us offensively.
(Difference in second half) The coaches did a good job at halftime and got them fired up and ready to go. They came out. It is tough, tough on these guys. They just keep coming back every week, it amazes me. They've got to do it again, two more times.
(Season a surprise, thinking you could get back into the bowl picture) It is a big surprise. A play here, a play there, an interception, a fumble, we competed well in five of the losses. Could have gone either way.
(Approach for last two games) We've got two neighbors coming in. You have the Ducks, then the Apple Cup and that has to be our bowl game. It will be theirs too. It ought to be a heck of a bowl game.
WSU PLAYER Loren Langley
(Long attempts) The 50 yarder I thought was good the whole time. I probably should have adjusted for the wind a little more. It blew left right at the last second and hit the post. Kind of upsetting. The 52, I wanted to make them both, but it didn't end up happening. I felt good, I felt like I kicked both of them pretty well.
(Points off board) I thought it was a good idea, actually. I though our offense was running well. I thought we had a shot to go ahead and take the lead. I thought it was a good idea to go for it because we had been doing well. I wasn't too frustrated at all. A field goal is a field goal from that short. It's not that big of a deal. If we had got it and then got stopped later I could have kicked another one. That wasn't a big deal to me. I honestly thought it was a good idea and that we should have gone for it.
WSU PLAYER Jerome Harrison
(Tough not going to a bowl game) I can't answer that or I get in trouble. I have no nice words to say about that, especially when I feel I was the reason we are not going. I should be able get a half yard in my sleep, with our without blocking, but I had blocking so I should have got the a half yard.
(Agree with going for the first down) Always, can't go against Coach Doba, he's the head coach. If he says go for it, I'm with him 110 percent.
(Lots of yards but no wins) It is disappointing. I would rather have 10 yards and six wins, than all these yards and all these losses. It is very tough. I just feel I should be doing more. If I was doing more we would be winning, so evidently it is not enough yards.
(100 yard streak mean anything) Not a thing. I'm not going to a bowl. Only these next two games mean something.
(playing in front of his mom) It is the best feeling, the best feeling in the world. She's the reason I'm here, I'm blessed to have here. It is always good to play in front of the women that made you, that made you the man you are. And she looks good, that makes me look pretty handsome too, so I thank here for that.
(final two games) We have great seniors, great individuals, great leaders and captains. Out of this oh and six, this part, the seniors and captains never let nobody put their heads down or start blaming or pointing fingers. We don't have a great group of individuals instead of athletes. We don't have that problem in our lockerroom.
WSU PLAYER Alex Brink
(Thoughts on the call) I think it was the right call. I think we would all be calling it probably the best call of the year if we get that half yard. I that was the way to go. If you put three points up and it is tied, maybe we get a break. That was the way to go at the time.
(were they overloaded on the side you were running) They had two guys outside and at the snap one guy jumped inside, he thought we were going to sneak, so we were probably better situation at the snap than we were prior to the snap. I think it was a play call.
(Late Sack) They covered it well. It was a route we ran earlier in the game. It think the corner kind of saw it. We were trying to get it to our inside receiver. They guy came through late. He made a hell of a play.
(Trandon Harvey) He's a leader, he kind of typifies those senior leaders who step up when their number is called, He hasn't been a guy all year we have looked to, but when we do look to him he's a guy who comes through for us. He's battled through some adversity and really come out and made some big plays for us.
(disappointed in not qualifying for a bowl) It is the worst disappointment, it is kind of what we were playing for these last three games. We really wanted obviously to go to a bowl and get that extra month of practice and go down and have an extra game. We have two games and we just have to battle and work hard.
(Next game - Oregon, special) I love playing Oregon, but I guess it doesn't really matter. It is another Pac-10 team and another Pac-10 opponent, just trying to get a win.
(Pac-10 win) We just need to work hard. You can't throw in the towel and say, we are not going to a bowl so we can't go play these two games. We have to go and work hard and battle. We have something to play for and we need to get a Pac-10 win, we have big games against the Ducks and the Dogs.
WSU PLAYER Mkristo Bruce
(Big three and out late) It was great to see our defense clicking. It hurts every time we come out and get them third and long and they just convert automatically. The crowd got into it, we had a lot of help. Bam, big play, have to start over again. It hurts.
(first to second half) It was just a different mentality. I think people started to realize if we don't win this game we are not going to a bowl game. It didn't turn out our way. Cougar defense, we started to show what real Cougar defense is at the end, which is bringing 11 hats to the ball, solid defense.
Arizona State Quotes
Head Coach Dirk Koetter
(on Rudy Carpenter's play) "I think Rudy did awesome. The first half, Rudy was spectacular. Rudy is still going through some growing pains, and at times trying to do too much. He's had so much success that I think sometimes Rudy thinks he's got an 'S' underneath that No. 12 and that he is Superman. He's got to learn that sometimes it's not there and you have to abort the mission. All young quarterbacks go through that. The flip side of that is that Rudy can make some plays running around. He did that in the first half tonight."
(on stopping the Cougars on fourth down after the offsides penalty) "There is no doubt in my mind when they had that field goal and we jumped offsides that they would go for that; the way they were running the ball. I think we would have probably done the same thing had the shoe been on the other foot. That was a huge, huge defensive play."
Quarterback Rudy Carpenter
(on the game) "We had a great game plan this week. We didn't want to get in third and long where we had to make conversions. But when we did, we did a great job converting them; guys were open and coming up with big catches. The offensive line did a great job giving me time too."
(on if he anticipated Zach Miller being open or if it played out that way) "It kind of just played out that way. We had a lot of things where it was either/or. If they played this coverage we had this; if they played that coverage we had someone else. They played a lot of the coverage we didn't expect them to play, so Zach was open a lot of times in the middle of the field and he came up with some big plays."
Tight End Zach Miller
(on why he was open) "They (WSU defense) were really getting deep...they would just leave me in the flats. They fixed that as the game went on but it worked for us for awhile."


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אנחנו בפייסבוק
Communications Ministry lifts ban on bringing Apple's new computer into country
Itai Smuskowitz
Published: 04.25.10, 11:08 / Israel Business
Itai Smuskowitz
iPad receives immigration visa: The Communications Ministry will notify Customs authorities on Sunday that it is now permissible to bring Apple's new computer into the country.
About a week and a half ago, the ministry deemed it forbidden
to bring the iPad into the country, citing incompatibility with Israel's Wi-Fi standard as it is configured to run on American Wi-Fi settings. Some 20 devices brought from abroad were confiscated and transferred to Customs.
The ministry lifted the ban Saturday night, claiming that tests run on the computers revealed that the device automatically adjusts its wireless broadcast intensity to match local standards, making it possible to run iPads in Israel without placing unnecessary strain on Wi-Fi networks.


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Let's make this simple. Detoxing is a natural process that is designed to occur on a daily and seasonal basis. Here is how the daily detox rhythm works: If you eat an early dinner (before 6 pm) and water fast for 13 hours, and get a good night's sleep your body will go through a […]
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Recently I was lucky enough to speak with Erica Salmon. Clearing a few moments from her non-stop schedule, she talked about her fashion creation Fantasy Fashion League as well as some current trends. The game puts your style savvy to use and is the fashionista's answer to fantasy football. While names like Manning and Urlacher are replaced by Valentino and Karl Lagerfeld, the concept is very similar. Check out the game at Fantasy Fashion League.com.
A Socialite Life: Not only do you have a Fashion League and a Celeb League, you are adding a new Beauty League option. Where did the addition stem from?
Erica Salmon: The game was lacking a beauty element and it was a factor that is often requested. It flexes your trend muscles and offers an upper hand to those whose forte isn't designer savvy. We were honored to team up with mark. (a division of Avon) to offer more options. We are proud to offer the Beauty League option for FREE. I am very excited to see how the new option goes.
ASL: Who is your red carpet pick this year?
Erica: Beyonce. Hands-down Beyonce. She has been my pick for most of the season. With all her Grammy awards and current nominations, she is an excellent source of points. I also think this is the year of the men. Last year George Clooney reigned, but this year offers more variety of male talent.
ASL: There are a ton of offers on your site. If you purchase a card to play in the Award Show Season for just $10, you also receive a year subscription to your choice of Lucky, Glamour, W, or Cookie. That is an amazing offer. Tell me about how that came to play.
Erica: The fashion gods smiled upon us and we were able to team up with Conde Nast. All of our big points come from the magazines the first Tuesday of every month. It just made sense to offer the magazines. Also we are awarding a trip for two to The Fashion Insider's LA Experience during Oscars Weekend. It ends January 15th, so you better hurry and submit an entry. It will be a ton of fun with shopping, a day of beauty, a tour and Santa Margherita Pinot Grigio tasting, and pre-Oscar party.
More of the Interview with Erica Salmon After the Jump.
ASL: On a not so fashion-related topic, what is your favorite TV show?
Erica: That is a good question. I don't get the opportunity to watch much television but the Soap Network ran an "Ugly Betty" marathon. It is a great show and plays to the fashion industry with a humorous twist. I also enjoy "Entourage."
ASL: Recently we had a huge Ugg debate. Do you have an opinion on the subject of the trend?
Erica: They are a trend but I do not own a pair. It really depends on what area you live in. Some parts of the country are just hitting the Ugg phenomenon while other parts have had their fill for the past few years. I just see little girls in my son's class wearing them and I base my feelings from that.
A special thanks to Erica and the entire team that makes Fantasy Fashion League work!


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Meteor stickgals face pair of losses
The Montrose Area field hockey team faced a 7-0 loss at home on Wednesday to Pittston and was handed a 3-1 loss from Berwick on the road on Tuesday afternoon.
Against Pittston, the Patriots scored five first half goals to put the Meteors at a 5-0 deficit at halftime, before chipping in a pair of goals in the second half to hand Montrose the 7-0 loss.
Montrose took four shots on goal and had two corner kicks while Taylor Wright had nine saves on goal.
On Tuesday, Berwick's Kelsey Rinehimer scored at 20:06 in the first half before Montrose's Katie Stranburg would knock in a goal at 18:08 with an assist from Anna Hamernick to make it a 1-1 game.
However, a pair of goals from Berwick's Brittany Fisher and Ashton Mensinger in the second half doomed the Meteors.
Montrose had 17 shots on goal and seven corners while Wright had eight saves on goal for the meteors.


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Immune Boosting Smoothie
Drink this smoothie whenever you need a boost of strong immunity, or whenever you feel like you might be getting sick. This smoothie will boost your immunity and strengthen your resilience to getting ill.
Total time: 10 minutes
Serves: 1
2 oranges, peeled and seeds removed
1 cup strawberries
1. Put all ingredients into a blender like a Vitamix and blend until smooth.
2. Drink!
1. Add ice for a cooler, thicker smoothie.
2. Freeze strawberries for a cooler smoothie.
+ Vegan and raw living nutrients
+ High in antioxidants
+ High in Vitamin C
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+ Increases energy
+ Aids Weight Loss
+ Healing Phytonutrients
EVERY single recipe on this website uses nature's ingredients, only. * Always choose ORGANIC, local and seasonal whenever possible.
This recipe was created by Liana Werner-Gray in NYC 2013.
Photo thanks to Rock'n Raw Photos– Raw and Unedited
This recipe is part of © 2013 The Earth Diet ™ All Rights Reserved
Print Recipe


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Every so often, so many items capture my attention that I either have to get them down on paper or accept the fact that I can never hope to catch up. But never let it be said that Prelutsky took the easy, logical, sane, commonsensical, approach.
To get the ball rolling, let me confess that I not only tend to shy away from non-fiction books in general, but even more so when it comes to biographies. I have multiple problems with them. To begin with, they are written by researchers and academicians, and so I usually find the writing dry and humorless. For another, they tend to begin with a rundown on the subject's ancestors. Although parents and grandparents may have played a huge role in the way the person turned out, if I wanted to read about them, I'd be reading their biographies. My third reason, shameful as it must sound to many of you, is that I'm not that interested in reading five or six hundred pages about any one person.
Before opening the floodgates to well-intentioned suggestions for my reading list, understand I have come to these conclusion through experience, not rumor. To me, sitting down with a biography is the equivalent of asking someone for the time and being told how to make a watch.
I confess that as cynical as I am, even I'm shocked that so many people seem to be up in arms over the NSA keeping track of millions of phone numbers, but are seemingly unconcerned that the ObamaCare website has rolled out the equivalent of a red carpet for every computer hacker between here and Timbuktu. They don't even have to say "Open Sesame" in order to know everything about you, including your medical history, your birthday, your social security number, your bank account and, yes, even your telephone number.
By this time, I assume everyone has seen the stomach-turning video of the little black child in a diaper being coached by his gangbanging uncle to repeat the most vulgar words imaginable. What I found interesting is that when some cop in Omaha used the word "thug" in referring to the uncle, the ACLU immediately jumped in to denounce him for employing a racist term. It's one thing to be a knucklehead and quite another to hire a skywriter to let the world know about it.
Everyone knows that "thug" is a generic word that has no racial connotations. Thugs come in all sizes, shapes and colors. But the mopes at the ACLU who'd go out of business if they couldn't trump up cases based on matters as trivial as hurt feelings or intentional misinterpretations of the Constitution, let us all know that whenever they hear "thug" or, I assume, "bully," "dope dealer," "rapist" or "scumbag," they immediately assume the reference is to a black person. I'm just asking, you understand, but doesn't that qualify as racist?
Although the next presidential election is still nearly three years off, I am already hearing from those who are certain that Obama is planning to pull off a coup so he can become a dictator for life.
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If your experience with Garrisons in World of Warcraft: Warlords of Draenor has been anything like mine, you're struggling to find enough Garrison resources to upgrade all your buildings and still send your followers on those snowball's chance in Hell missions in case the RNG gods shine upon you. The Lumber Mill is a medium size building that's great for increasing your Garrison resources because it allows you to exchange 10 Timber for 20 Garrison resources per work order. That amount increases to 30 resources if you assign a follower named Phylarch the Evergreen to work on the Lumber Mill. But what's the fastest way of getting that Timber?
Warlords is Punishing Me for Leveling Wrong
I haven't done any quests in the Dread Wastes. Yes, that dark, sha-infested zone back on Pandaria. I only ever went there to hunt rares and get to Heart of Fear. The Dread Wastes were always just a place that I went through to get somewhere else. Dread Wastes (and Townlong Steppes, which I did finish) was optional content, and that's okay.
Carmelo and I hit level 90 while questing in Kun-Lai Summit. We had done every quest we could find in the Jade Forest, Valley of the Four Winds, and Krasarang Wilds. We had gotten halfway through Kun-Lai when we hit 90. Our gear was in the 430-440 range when we did, and we needed to reach 450 to do heroic dungeons. So we started earning reputation for the Golden Lotus, which would unlock Justice Point gear and dailies for the August Celestials and Shado-Pan. We were capped on Justice Points from Cataclysm, so we didn't need to run any dungeons to earn more. (Though we did run dungeons for gear, most of which was disenchanted.) We had collected several stacks of Windwool Cloth from our journey, which Carmelo crafted into cloth gear for us.
We were doing dailies, running dungeons, running scenarios, and occasionally farming materials while waiting for a queue. Don't get me wrong, we didn't like being forced to do Golden Lotus dailies every day before we could do other stuff, but at least there were dailies to do.
Warlords of Draenor is a different beast altogether.
Time Travel in Warlords of Draenor
I always hate it when my fiction turns to time travel for plot devices because it's so rarely done properly. Blizzard recently revealed its new World of Warcraft expansion called Warlords of Draenor. In a tinfoil hat edition of Know Your Lore, Matthew Rossi delves into what he believes the expansion means for the manipulation of time we've seen in WoW. I have a bit of a different take on what the new storyline means and how time travel within WoW works.
WoW's Character Model Update: A Closer Look
Have you ever noticed how much better Guild Wars 2, The Last of Us, and Assassin's Creed look compared to World of Warcraft? It's because the artists at Blizzard are lazy! They could have updated all of the old character models by now if they just put in a little bit of effort. I also think we should have advanced character customization similar to Saints Row or Mass Effect. Also, all of the current armor looks terrible, so they should spend a few minutes fixing that, too.
Are you cringing yet? If I were reading that paragraph in a comment, I would be.
Updating the old character models is a monumental task. Last time, I covered the basics of what a model is. Today, I'm going to be telling you about the things Blizzard does that makes a model update more complicated than most players think.
WoW's Character Model Update: A Primer
Want to make me cringe? Make a post on Blizzard's official World of Warcraft forums, or a fansite's WoW forums, and demand that Blizzard updates the character models for WoW. Say that updating the models is easy and the artists are lazy. Be sure to mention how other games like RIFT, Guild Wars 2, or The Last of Us have much better looking character models. Then, include a wish-list of things you want to see on the updated character models.
I cringe because nearly everyone demonstrates a complete lack of understanding of how WoW's models work, let alone character modeling at large. Updating the models is a monumental task. There is a lot going on under the hood. There isn't some magic button the artists can click that instantly upgrades everything to a higher polygon count. (Even if there were, there'd still be quite a bit of work to do to get the models ready for use in-game!)
Updating character models isn't going to be an easy task. First, let me try to explain what a model is. We can get into updating the character models later.


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A former Marine stationed here in Eastern Carolina has been convicted for killing a friend's toddler daughter near a Southern California desert military base.
A San Bernardino County jury in Joshua Tree on Thursday found 23-year-old Joshua Kruzik guilty of second-degree murder and assault on a child resulting in death.
Kruzik was a corporal at New River Air Station in Jacksonville when he fatally stuck 18-month-old Audrey Allen to make her stop crying. That happened in California where he was training. He had agreed to babysit the toddler for her parents, who were fellow Marines.
Kruzik faces a possible life prison term when he's sentenced on Nov. 30.
Kruzik was dishonorably discharged.


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LINCOLN COUNTY, Mo. (KSDK) - A Foley, Mo. man has been charged after a woman was found handcuffed to a steering wheel Friday.
Deputies were called to the 100 block of Wild Horse Drive in Foley to find the woman handcuffed to a steering wheel. She told authorities she had been arguing with 32-year-old Tracy Lynn Muse while they were driving, and he threw her cell phone out the window.
She said Muse grabbed her by the throat and slammed her head into the vehicle's console while she was still driving. She said once they arrived at the home, Muse continued to assault her and handcuffed her to the steering wheel, removed the starter fuse from the vehicle to prevent her from leaving, and then took the keys.
Police say a concerned citizen called 911.
Muse drove from the home in a separate vehicle. He was arrested in Troy and charged with felony domestic assault and false imprisonment. He is currently held at the Lincoln County Jail on a $25,000 cash-only bond.


text:
ELYRIA – Two more people have been indicted in connection with the death of 3-year-old Jesse Crum Jr. in March.
Dallas Jones, 55, and Therese Jones, 50, are each charged with three counts of endangering children. The Joneses own the Amherst home where Jesse was staying when he was injured.
Alyson Sweany, Jesse's mother, was indicted last week on three counts of endangering children as well. She allegedly violated her duty to care for her child, according to prosecutors.
Jesse was taken to MetroHealth Medical Center on March 12, but died a few days later. He suffered head injuries caused by violence of an undetermined origin, according to the Cuyahoga County Coroner's Office.
Sweany's attorney has said Jesse was injured accidentally a few days before he was taken to the hospital. He had appeared normal until the day he was taken to the hospital, attorney John Chambers has said.
The Jones were also charged with illegal cultivation of marijuana, possession of marijuana and possession of drug paraphernalia.
The couple, who were arrested this afternoon, are the parents of Peter Jones, who hanged himself in their home in June. He had been awaiting sentencing on charges of endangering children for scalding Jesse while giving the boy a bay in January 2009.
For more on this story, see Saturday's Chronicle.


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Smart Driving
Want to save money and reduce pollution, too?
Sometimes called "Eco-Driving," Smart Driving is a set of strategies and techniques that maximize fuel efficiency by improving driving habits and vehicle maintenance. These actions can improve gas mileage, reduce fuel costs, increase safety, and lessen stress. Smart driving also helps improve air quality by reducing greenhouse gas (GHG) emissions from our cars.
Here are a few simple tips to help improve your gas mileage while driving your existing vehicle:
Choose the least congested routeChoosing the least congested route keeps you from idling in traffic, which cuts down on the amount of emissions from your car's tailpipe. Go to the 511 Traffic page to get the current traffic conditions, driving times and alternate routes to find the least congested way to go.
Slow downFollow the speed limit. When driving on freeways, reducing your speed from 75 miles per hour to 65 miles per hour can improve your gas mileage by 15 percent.
Smooth and steadyAccelerate and decelerate smoothly. Reduce aggressive driving to increase your gas mileage by up to 33 percent (highway) and 5 percent (street).
Tune it upFollow the manufacturer's recommendations for regular oil changes, service and maintenance. Improve your mileage by 4 percent by keeping your car in good working condition.
Lighten the loadClean out your car and the trunk. For every 100 pounds you remove, your fuel economy will increase by 2 percent.
Pump 'em upCheck your tire pressure monthly. Keep your tires inflated to the recommended pressure, and you'll improve your fuel economy by 2-3 percent.
Smart driving activities, when done together, can improve vehicle efficiency by up to 15 percent, and in some cases up to 30 percent, all while reducing the emissions that pollute our air.
You Can Help!
MTC is looking for Bay Area drivers to participate in our smart driving pilot program. Learn more about smart driving and earn incentives for your participation.
Three easy to remember steps:
Anticipate – Adapt your speed to what is happening ahead.
Drive a Steady Speed – Follow the speed limit and avoid aggressive acceleration and deceleration.
Maintain Your Vehicle – Regularly inflate tires, change the oil, and check filters.


text:
CORNELIUS – The body of Matthew Bell, the 33-year-old charter boat captain who fell off "The Ragin' Mistress" during a cruise Sept. 1, was discovered by a boater Sept. 13, Sgt. Barry Rowell of the N.C. Wildlife Resources Commission said.
Members of the Cornelius firefighters recovered his body that Saturday afternoon near Marker D4, off Shearwater Point Drive in Cornelius.
A Charlotte resident, Bell was on the charter boat in an unofficial capacity along with 102 other passengers and six crew members the evening of the accident. Luxury Yacht Charters, the company who runs the vessel, did employ him as a charter boat captain, according to Rowell.
Rowell added that details remain unknown regarding how Bell fell into the 100-foot depths of the lake two weeks ago. An investigation is ungoing, he said, and an autoposy will be performed.


text:
St.Valentine's Day chocolate seal
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PAPA The Man - The Myth - The Legend Designed by PhLong
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JOIN US THIS WEEK for a short discussion about BioInformatics LLC's upcoming multi-sponsor report: Lab Budgets and Sources of Funding in 2014: The Market Outlook for the United States, Europe and Asia.
This informational webcast will take place at two different times:
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- Get an overview of the economic landscape that frames the report
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Join your colleagues on this discussion about our upcoming published report on lab budgets and sources of funding in 2014.
BioInformatics LLC has been conducting market research on scientific markets for almost two decades. We look forward to providing you with an overview of our upcoming published report.
Register Here!


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The World Vaccines Market Is Predicted...
Researchers Are Developing Ways to Edit...
RNAi Is Working on Tactics to...
To Know Where Biosimilars Are Going,...
A team of researchers report developing a quicker technique to separate E. coli strains based on specific SNPs. Using this, they were able to isolate more virulent ones.
"It used to take three months to score one gene individually," says Thomas Whittam, Ph.D., Hannah distinguished professor at the National Food Safety and Toxicology Center at Michigan State University (MSU). "Now, we are working with a new, more rapid system that can do thousands of genes per day."
Using this system, which detects SNPs in 96 loci of the bacteria, the researchers looked at the DNA of more than 500 strains of O157:H7. They discovered that individual bacteria could be separated into nine major groups called clades.
E. coli makes people sick because they produce toxins, called Shiga toxins. These toxins block protein synthesis. What the investigators found was that the different clades produced different kinds of Shiga toxins in varying amounts based on their DNA.
"For the first time, we know why some outbreaks cause serious infections and diseases and others don't," Dr. Whittam reports.
Aside from MSU, researchers from the University of Medicine and Dentistry of New Jersey, Michigan Department of Community Health, Illinois Institute of Technology, and the Centers for Disease Control and Prevention were also invovled. The study was published on March 10 in the Proceedings of the National Academy of Sciences.
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hi I was wondering whether anyone knows of a way to order which dependencies get called first. The issue I have is that I am including geronimo jaxws spec 2.2, but the jre version of javax.xml.ws.Service is being picked up instead of the dependency version. I tried putting the dependency first on the dependency list and tried dependency-management to no success (maybe I am using it wrong). When in eclipse i can tell it to pick up the jars in maven dependencies first, but i don't know how to do that in maven.
Many thanks.


text:
An Afternoon with Author Donia Bijan
For Donia Bijan's family, food has been the language they use to tell their stories and communicate their love. In 1978, when the Islamic revolution in Iran threatened their safety, they fled to California's Bay Area, where the familiar flavors of Bijan's mother's cooking formed a bridge to the life left behind. Now, through the prism of food, award-winning chef Donia Bijan unwinds her story, finding at the heart of it all is her mother, whose love and support enabled Bijan to realize her dreams.
There will be a book signing and reception after her talk.
Domingo, 12/02/12 at 2:00 pm
Persona de Contacto:
Cynthia Rider
Número de Contacto:
650.574.4842 x236
Foster City
Tipo de evento:
Author Program
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药物信息为Tramadol Hydrochloride (Physicians Total Care, Inc.): PRECAUTIONS
- 外部链接相关的Tramadol Hydrochloride (Physicians Total Care, Inc.)
The administration of tramadol hydrochloride may complicate the clinical assessment of patients with acute abdominal conditions.
Impaired renal function results in a decreased rate and extent of excretion of tramadol and its active metabolite, M1. In patients with creatinine clearances of less than 30 mL/min, dosing reduction is recommended (see DOSAGE AND ADMINISTRATION). Metabolism of tramadol and M1 is reduced in patients with advanced cirrhosis of the liver. In cirrhotic patients, dosing reduction is recommended (see DOSAGE AND ADMINISTRATION).
With the prolonged half-life in these conditions, achievement of steady-state is delayed, so that it may take several days for elevated plasma concentrations to develop.
- Patients should be informed that tramadol hydrochloride may cause seizures and/or serotonin syndrome with concomitant use of serotonergic agents (including SSRIs, SNRIs, and triptans) or drugs that significantly reduce the metabolic clearance of tramadol.
- may impair mental or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.
- Tramadol hydrochloride should not be taken with alcohol containing beverages.
- Tramadol hydrochloride should be used with caution when taking medications such as tranquilizers, hypnotics or other opiate containing analgesics.
- The patient should be instructed to inform the physician if they are pregnant, think they might become pregnant, or are trying to become pregnant (see PRECAUTIONS, Labor and Delivery).
- The patient should understand the single-dose and 24-hour dose limit and the time interval between doses, since exceeding these recommendations can result in respiratory depression, seizures and death.
CYP2D6 and CYP3A4 Inhibitors
Concomitant administration of CYP2D6 and/or CYP3A4 inhibitors (see CLINICAL PHARMACOLOGY, Pharmacokinetics), such as quinidine, fluoxetine, paroxetine and amitriptyline (CYP2D6 inhibitors), and ketoconazole and erythromycin (CYP3A4 inhibitors), may reduce metabolic clearance of tramadol increasing the risk for serious adverse events including seizures and serotonin syndrome.
Serotonergic Drugs
There have been postmarketing reports of serotonin syndrome with use of tramadol and SSRIs/SNRIs or MAOIs and a2-adrenergic blockers. Caution is advised when tramadol hydrochloride is coadministered with other drugs that may affect the serotonergic neurotransmitter systems, such as SSRIs, MAOIs, triptans, linezolid (an antibiotic which is a reversible non-selective MAOI), lithium, or St. John's Wort. If concomitant treatment of tramadol hydrochloride with a drug affecting the serotonergic neurotransmitter system is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases (see WARNINGS, Serotonin Syndrome).
Based on the mechanism of action of tramadol and the potential for serotonin syndrome, caution is advised when tramadol hydrochloride is coadministered with a triptan. If concomitant treatment of tramadol hydrochloride with a triptan is clinically warranted, careful observation of the patient is advised, particularly during treatment initiation and dose increases (see WARNINGS, Serotonin Syndrome).
Use With Carbamazepine
Patients taking carbamazepine may have a significantly reduced analgesic effect of tramadol hydrochloride. Because carbamazepine increases tramadol metabolism and because of the seizure risk associated with tramadol, concomitant administration of tramadol hydrochloride and carbamazepine is not recommended.
Use With Quinidine
Tramadol is metabolized to M1 by CYP2D6. Quinidine is a selective inhibitor of that isoenzyme, so that concomitant administration of quinidine and tramadol hydrochloride results in increased concentrations of tramadol and reduced concentrations of M1. The clinical consequences of these findings are unknown. In vitro drug interaction studies in human liver microsomes indicate that tramadol has no effect on quinidine metabolism.
Potential for Other Drugs to Affect Tramadol
In vitro drug interaction studies in human liver microsomes indicate that concomitant administration with inhibitors of CYP2D6 such as fluoxetine, paroxetine, and amitriptyline could result in some inhibition of the metabolism of tramadol. Administration of CYP3A4 inhibitors, such as ketoconazole and erythromycin, or inducers, such as rifampin and St. John's Wort, with tramadol hydrochloride may affect the metabolism of tramadol leading to alteted tramadol exposure.
Potential for Tramadol to Affect Other Drugs
In vitro studies indicate that tramadol is unlikely to inhibit the CYP3A4-mediated metabolism of other drugs when tramadol is administered concomitantly at therapeutic doses. Tramadol does not appear to induce its own metabolism in humans, since observed maximal plasma concentrations after multiple oral doses are higher than expected based on single-dose data. Tramadol is a mild inducer of selected drug metabolism pathways measured in animals.
Use With Cimetidine
Concomitant administration of tramadol hydrochloride® with cimetidine does not result in clinically significant changes in tramadol pharmacokinetics. Therefore, no alteration of the tramadol hydrochloride dosage regimen is recommended.
Use With Digoxin and Warfarin
Post-marketing surveillance has revealed rare reports of digoxin toxicity and alteration of warfarin effect, including elevation of prothrombin times.
A slight, but statistically significant, increase in two common murine tumors, pulmonary and hepatic, was observed in a mouse carcinogenicity study, particularly in aged mice. Mice were dosed orally up to 30 mg/kg (90 mg/m2 or 0.36 times the maximum daily human dosage of 246 mg/m2) for approximately two years, although the study was not done with the Maximum Tolerated Dose. This finding is not believed to suggest risk in humans. No such finding occurred in a rat carcinogenicity study (dosing orally up to 30 mg/kg, 180 mg/m2, or 0.73 times the maximum daily human dosage).
Tramadol was not mutagenic in the following assays: Ames Salmonella microsomal activation test, CHO/HPRT mammalian cell assay, mouse lymphoma assay (in the absence of metabolic activation), dominant lethal mutation tests in mice, chromosome aberration test in Chinese hamsters, and bone marrow micronucleus tests in mice and Chinese hamsters. Weakly mutagenic results occurred in the presence of metabolic activation in the mouse lymphoma assay and micronucleus test in rats. Overall, the weight of evidence from these tests indicates that tramadol does not pose a genotoxic risk to humans.
No effects on fertility were observed for tramadol at oral dose levels up to 50 mg/kg (300 mg/m2) in male rats and 75 mg/kg (450 mg/m2) in female rats. These dosages are 1.2 and 1.8 times the maximum daily human dosage of 246 mg/m2, respectively.
Tramadol has been shown to be embryotoxic and fetotoxic in mice, (120 mg/kg or 360 mg/m2), rats (=25 mg/kg or 150 mg/m2) and rabbits (=75 mg/kg or 900 mg/m2) at maternally toxic dosages, but was not teratogenic at these dose levels. These dosages on a mg/m2 basis are 1.4, =0.6, and =3.6 times the maximum daily human dosage (246 mg/m2) for mouse, rat and rabbit, respectively.
No drug-related teratogenic effects were observed in progeny of mice (up to 140 mg/kg or 420 mg/m2), rats (up to 80 mg/kg or 480 mg/m2) or rabbits (up to 300 mg/kg or 3600 mg/m2) treated with tramadol by various routes. Embryo and fetal toxicity consisted primarily of decreased fetal weights, skeletal ossification and increased supernumerary ribs at maternally toxic dose levels. Transient delays in developmental or behavioral parameters were also seen in pups from rat dams allowed to deliver. Embryo and fetal lethality were reported only in one rabbit study at 300 mg/kg (3600 mg/m2), a dose that would cause extreme maternal toxicity in the rabbit. The dosages listed for mouse, rat and rabbit are 1.7, 1.9 and 14.6 times the maximum daily human dosage (246 mg/m2), respectively.
Tramadol was evaluated in peri- and post-natal studies in rats. Progeny of dams receiving oral (gavage) dose levels of 50 mg/kg (300 mg/m2 or 1.2 times the maximum daily human tramadol dosage) or greater had decreased weights, and pup survival was decreased early in lactation at 80 mg/kg (480 mg/m2 or 1.9 and higher the maximum daily human dose).
There are no adequate and well-controlled studies in pregnant women. Tramadol Hydrochloride should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Neonatal seizures, neonatal withdrawal syndrome, fetal death and still birth have been reported during post-marketing.
Tramadol hydrochloride should not be used in pregnant women prior to or during labor unless the potential benefits outweigh the risks. Safe use in pregnancy has not been established. Chronic use during pregnancy may lead to physical dependence and post-partum withdrawal symptoms in the newborn (see DRUG ABUSE AND DEPENDENCE). Tramadol has been shown to cross the placenta. The mean ratio of serum tramadol in the umbilical veins compared to maternal veins was 0.83 for 40 women given tramadol during labor.
The effect of tramadol hydrochloride, if any, on the later growth, development, and functional maturation of the child is unknown.
Tramadol hydrochloride is not recommended for obstetrical preoperative medication or for post-delivery analgesia in nursing mothers because its safety in infants and newborns has not been studied. Following a single IV 100 mg dose of tramadol, the cumulative excretion in breast milk within 16 hours postdose was 100 µg of tramadol (0.1% of the maternal dose) and 27 µg of M1.
The safety and efficacy of tramadol hydrochloride in patients under 16 years of age have not been established. The use of tramadol hydrochloride in the pediatric population is not recommended.
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function and of concomitant disease or other drug therapy. In patients over 75 years of age, daily doses in excess of 300 mg are not recommended (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION).
A total of 455 elderly (65 years of age or older) subjects were exposed to tramadol hydrochloride in controlled clinical trials. Of those, 145 subjects were 75 years of age and older.
In studies including geriatric patients, treatment-limiting adverse events were higher in subjects over 75 years of age compared to those under 65 years of age. Specifically, 30% of those over 75 years of age had gastrointestinal treatment-limiting adverse events compared to 17% of those under 65 years of age. Constipation resulted in discontinuation of treatment in 10% of those over 75.
- Drug Information Provided by National Library of Medicine (NLM).


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Hi Secrets Family
I was able to touch the same microphone that Elvis & Johnny Cash(plus others)used!!
Graceland was beautiful but sad
Love Johnie xoxo
Sunridge Woods Villa Oct 2000 & 2002
Esprit/Calabay Parc Oct 2004
Sunset Ridge Oct 2008
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thx for the card x
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text:
anabolic steroid
Anabolic steroids, technically known as anabolic-androgenic steroids (AAS) or colloquially as "steroids", are drugs that mimic the effects of vocal cords, testicles, and body hair (secondary sexual characteristics). The word anabolic comes from the Greek ἀναβολή anabole, "that which is thrown up, mound", and the word androgenic from the Greek ἀνδρός andros, "of a man" + -γενής -genes, "born".
Anabolic steroids were first isolated, identified, and synthesized in the 1930s, and are now used therapeutically in medicine to stimulate bone growth and appetite, induce male puberty, and treat chronic wasting conditions, such as cancer and AIDS. The American College of Sports Medicine acknowledges that AAS, in the presence of adequate diet, can contribute to increases in body weight, often as lean mass increases, and that the gains in muscular strength achieved through high-intensity exercise and proper diet can be additionally increased by the use of AAS in some individuals.[1]
Health risks can be produced by long-term use or excessive doses of anabolic steroids.testicular atrophy may also be caused by anabolic steroids.
counterfeit drugs are sold to users.
[edit] History
[edit] Isolation of gonadal AAS
The use of [8]
In the 1930s, it was already known that the testes contain a more powerful androgen than androstenone, and three groups of scientists, funded by competing pharmaceutical companies in the Netherlands, Germany, and Switzerland, raced to isolate it.[8][9] This hormone was first identified by Karoly Gyula David, E. Dingemanse, J. Freud and Ernst Laqueur in a May 1935 paper "On Crystalline Male Hormone from Testicles (Testosterone)."[10] They named the hormone testosterone, from the stems of testicle and sterol, and the suffix of ketone. The chemical synthesis of testosterone was achieved in August that year, when Butenandt and G. Hanisch published a paper describing "A Method for Preparing Testosterone from Cholesterol."[11] Only a week later, the third group, Ruzicka and A. Wettstein, announced a patent application in a paper "On the Artificial Preparation of the Testicular Hormone Testosterone (Androsten-3-one-17-ol)."[12] Ruzicka and Butenandt were offered the 1939 Nobel Prize in Chemistry for their work, but the Nazi government forced Butenandt to decline the honor, although he accepted the prize after the end of World War II.[8][9]
Clinical trials on humans, involving either oral doses of [13]
[edit] Development of synthetic AAS
The development of muscle-building properties of testosterone was pursued in the 1940s, in the Soviet Union and in [5]
Three major ideas governed modifications of testosterone into a multitude of AAS: Alkylation at 17-alpha position with methyl or ethyl group created orally active compounds because it slows the degradation of the drug by the liver; esterification of testosterone and nortestosterone at the 17-beta position allows the substance to be administered parenterally and increases the duration of effectiveness because agents soluble in oily liquids may be present in the body for several months; and alterations of the ring structure were applied for both oral and parenteral agents to seeking to obtain different anabolic to androgenic effect ratios.[17]
[edit] Pharmacology
[edit] Routes of administrations
There are four common forms in which anabolic steroids are administered: oral pills, injectable steroids, creams/gels for topical application, and skin patches. Oral administration is the most convenient. Testosterone administered by mouth is rapidly absorbed, but it is largely converted to inactive metabolites, and only about 1/6 is available in active form. In order to be sufficiently active when given by mouth, testosterone derivatives are alkylated at the 17 position, e.g. fluoxymesterone. This modification reduces the liver's ability to break down these compounds before they reach the systemic circulation.
Testosterone can be administered embolism (clot) in the bloodstream.
Transdermal patches (adhesive patches placed on the skin) may also be used to deliver a steady dose through the skin and into the bloodstream. Testosterone-containing creams and gels that are applied daily to the skin are also available, but absorption is inefficient (roughly 10%, varying between individuals) and these treatments tend to be more expensive. Individuals who are especially physically active and/or bathe often may not be good candidates, since the medication can be washed off and may take up to six hours to be fully absorbed. There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering anabolic steroids for non-medical purposes.[19]
The traditional routes of administration do not have differential effects on the efficacy of the drug. Studies indicate that the anabolic properties of anabolic steroids are relatively similar despite the differences in pharmacokinetic principles such as [20]
[edit] Mechanism of action
The [24]
The effect of anabolic steroids on muscle mass is caused in at least two ways:basal metabolic rate (BMR), since an increase in muscle mass increases BMR.
[edit] Anabolic and androgenic effects
As the name suggests, anabolic-androgenic steroids have two different, but overlapping, types of effects: anabolic, meaning that they promote virilising), meaning that they affect the development and maintenance of masculine characteristics.
Some examples of the anabolic effects of these hormones are increased [30]
The androgenic effects of AAS are numerous. Depending on the length of use, the side effects of the steroid can be irreversible. Processes affected include pubertal growth, sebaceous gland oil production, and sexuality (especially in fetal development). Some examples of virilizing effects are growth of the clitoris in females and the penis in male children (the adult penis does not grow, and will eventually get smaller even when exposed to high doses of androgens), increased growth of androgen-sensitive hair (pubic, beard, chest, and limb hair), increased vocal cord size, deepening the voice, increased libido, suppression of natural sex hormones, and impaired production of sperm.[31]
The androgenic:anabolic ratio of an AAS is an important factor when determining the clinical application of these compounds. Compounds with a high ratio of androgenic to an anabolic effects are the drug of choice in androgen-replacement therapy (e.g., treating hypogonadism in males), whereas compounds with a reduced androgenic:anabolic ratio are preferred for anemia and osteoporosis, and to reverse protein loss following trauma, surgery, or prolonged immobilization. Determination of androgenic:anabolic ratio is typically performed in animal studies, which has led to the marketing of some compounds claimed to have anabolic activity with weak androgenic effects. This disassociation is less marked in humans, where all anabolic steroids have significant androgenic effects.[18]
A commonly used protocol for determining the androgenic:anabolic ratio, dating back to the 1950s, uses the relative weights of ventral Hershberger assay.
[edit] Body composition and strength improvements
A review spanning more than three decades of experimental studies in men found that body weight may increase by 2–5 kg as a result of short-term (<10 weeks) AAS use, which may be attributed mainly to an increase of lean mass. Animal studies also found that fat mass was reduced, but most studies in humans failed to elucidate significant fat mass decrements. The effects on lean body mass have been shown to be dose-dependent. Both muscle hypertrophy and the formation of new muscle fibers have been observed. The hydration of lean mass remains unaffected by AAS use, although small increments of blood volume cannot be ruled out.[33]
The upper region of the body (thorax, neck, shoulders, and upper arm) seems to be more susceptible for AAS than other body regions because of predominance of androgen receptors in the upper body. The largest difference in muscle fiber size between AAS users and non-users was observed in type I muscle fibers of the vastus lateralis and the trapezius muscle as a result of long-term AAS self-administration. After drug withdrawal, the effects fade away slowly, but may persist for more than 6–12 weeks after cessation of AAS use.[33]
The same review observed strength improvements in the range of 5–20% of baseline strength, depending largely on the drugs and dose used as well as the administration period. Overall, the exercise where the most significant improvements were observed is the [38]
[edit] Adverse effects
Anabolic steroids can cause many [46]
High doses of oral anabolic steroid compounds can cause liver damage, as the steroids are metabolized (17α-alkylated) in the digestive system to increase their bioavailability and stability.[3]
There are also sex-specific side-effects of anabolic steroids. Development of breast tissue in males, a condition called [52]
A number of severe side-effects can occur if adolescents use anabolic steroids.
For example, the steroids may prematurely stop the lengthening of bones (premature epiphyseal fusion through increased levels of estrogen metabolites), resulting in stunted growth. Other effects include, but are not limited to, accelerated bone maturation, increased frequency and duration of erections, and premature sexual development. Anabolic steroid use in adolescence is also correlated with poorer attitudes related to health.[53]
Other side-effects can include alterations in the structure of the [58]
[edit] Psychiatric effects
A 2005 review in [62]
Large-scale long-term studies of psychiatric effects on AAS users are not currently available.[64]
[edit] Aggression and hypomania
From the mid-1980s onward, the media reported "roid rage" as a side-effect of AAS.[65]
A 2005 review determined that some, but not all, randomized controlled studies have found that anabolic steroid use correlates with [68]
A 2006 study of two pairs of identical twins, in which one twin used anabolic steroids and the other did not, found that in both cases the steroid-using twin exhibited high levels of aggressiveness, hostility, anxiety, and paranoid ideation not found in the "control" twin.[72]
[edit] Depression and suicide
The relationship between AAS use and depression is inconclusive. There have been anecdotal reports of depression and suicide in teenage steroid users,[74]
[edit] Addiction potential
In an animal study, male rats developed a conditioned place preference to testosterone injections into the nucleus accumbens, an effect blocked by dopamine antagonists, which suggests that androgen reinforcement is mediated by the brain. Moreover, testosterone appears to act through the mesolimbic dopamine system, a common substrate for drugs of abuse. Nonetheless, androgen reinforcement is not comparable to that of cocaine, nicotine, or heroin. Instead, testosterone resembles other mild reinforcers, such as caffeine, or benzodiazepines. The potential for androgen addiction remains to be determined.[75]
[edit] Medical and ergogenic uses
[edit] Medical uses
Since the discovery and synthesis of testosterone in the 1930s, anabolic steroids have been used by physicians for many purposes, with varying degrees of success, for the treatment of:
- Bone marrow stimulation: For decades, anabolic steroids were the mainstay of therapy for hypoplastic anemias due to leukemia or kidney failure, especially aplastic anemia.[76] Anabolic steroids have largely been replaced in this setting by synthetic protein hormones (such as epoetin alfa) that selectively stimulate growth of blood cell precursors.
- Growth stimulation: Anabolic steroids can be used by pediatric endocrinologists to treat children with growth failure.[77] However, the availability of synthetic growth hormone, which has fewer side effects, makes this a secondary treatment.
- Stimulation of [79]
- Induction of male puberty: Androgens are given to many boys distressed about extreme delay of puberty. Testosterone is now nearly the only androgen used for this purpose and has been shown to increase height, weight, and fat-free mass in boys with delayed puberty.[80]
- [81]
- Stimulation of lean body mass and prevention of [85]
- [89]
- Gender Identity Disorder, by producing secondary male characteristics, such as a deeper voice, increased bone and muscle mass, facial hair, increased levels of red blood cells, and clitoral enlargement in female-to-male patients.[90]
It should be noted that although steroids do have medical uses, they may also have side effects – for example, the potential risk of citation needed].
[edit] Ergogenic use and abuse
Between 1 million and 3 million people (1% of the population) are thought to have misused AAS in the United States.[95]
Anabolic steroid users tend to be disillusioned by the portrayal of anabolic steroids as deadly in the media and in politics.[98]
Anabolic steroids have been used by men and women in many different kinds of professional sports to attain a competitive edge or to assist in recovery from injury. These sports include bodybuilding, weightlifting, shot put and other track and field, cycling, baseball, wrestling, mixed martial arts, boxing, football, and cricket. Such use is prohibited by the rules of the governing bodies of most sports. Anabolic steroid use occurs among adolescents, especially by those participating in competitive sports. It has been suggested that the prevalence of use among high-school students in the U.S. may be as high as 2.7%.[99] Male students used anabolic steroids more frequently than female students and, on average, those that participated in sports used steroids more often than those that did not.
[edit] Legal and sport restrictions
[edit] Legal status
The legal status of anabolic steroids varies from country to country: some have stricter controls on their use or prescription than others though in many countries they are not illegal. In the U.S., anabolic steroids are currently listed as Schedule III Thailand.
[edit] United States
The history of the U.S. legislation on anabolic steroids goes back to the late 1980s, when the U.S. Congress considered placing anabolic steroids under the Controlled Substances Act following the controversy over Ben Johnson's victory at the 1988 Summer Olympics in Seoul. During deliberations, the American Medical Association (AMA), Drug Enforcement Administration (DEA), Food and Drug Administration (FDA) as well as the National Institute on Drug Abuse (NIDA) all opposed listing anabolic steroids as controlled substances, citing the fact that use of these hormones does not lead to the physical or psychological dependence required for such scheduling under the Controlled Substance Act. Nevertheless, anabolic steroids were added to Schedule III of the Controlled Substances Act in the Anabolic Steroid Control Act of 1990.[105]
The same act also introduced more stringent controls with higher criminal penalties for offenses involving the illegal distribution of anabolic steroids and human growth hormone. By the early 1990s, after anabolic steroids were scheduled in the U.S., several pharmaceutical companies stopped manufacturing or marketing the products in the U.S., including Ciba, Searle, Syntex, and others. In the Controlled Substances Act, anabolic steroids are defined to be any drug or hormonal substance chemically and pharmacologically related to testosterone (other than estrogens, progestins, and corticosteroids) that promote muscle growth. The act was amended by the Anabolic Steroid Control Act of 2004, which added prohormones to the list of controlled substances, with effect from January 20, 2005.[106]
[edit] United Kingdom
In the United Kingdom, anabolic steroids are classified as class C drugs for their illegal abuse potential, which puts them in the same class as doping regulations in sports.
[edit] Status in sports
Anabolic steroids are banned by all major sports bodies including [119]
[edit] Detection of use
The most commonly employed human physiological specimen for detecting anabolic steroid usage is urine, although both blood and hair have been investigated for this purpose. The anabolic steroids, whether of endogenous or exogenous origin, are subject to extensive hepatic biotransformation by a variety of enzymatic pathways. The primary urinary metabolites may be detectable for up to 30 days after the last use, depending on the specific agent, dose and route of administration. A number of the drugs have common metabolic pathways, and their excretion profiles may overlap those of the endogenous steroids, making interpretation of testing results a very significant challenge to the analytical chemist. Methods for detection of the substances or their excretion products in urine specimens usually involve [123]
[edit] Illegal trade
Anabolic steroids are frequently produced in pharmaceutical laboratories, but, in nations where stricter laws are present, they are also produced in small home-made underground laboratories, usually from raw substances imported from abroad.[127]
In the late 2000s, the worldwide trade in illicit AAS increased significantly, and authorities announced record captures on three continents. In 2006, Finnish authorities announced a record seizure of 11.8 million AAS tablets. A year later, the DEA seized 11.4 million units of AAS in the largest U.S seizure ever. In the first three months of 2008, Australian customs reported a record 300 seizures of AAS shipments.[128]
In the U.S., Canada, and Europe, illegal steroids are sometimes purchased just as any other illegal drug, through dealers who are able to obtain the drugs from a number of sources. Illegal anabolic steroids are sometimes sold at gyms and competitions, and through the mail, but may also be obtained through pharmacists, veterinarians, and physicians.[130]
[edit] See also
131.Tygart, Travis T. "Steroids, the Media, and Youth." Prevention Researcher Integrated Research Services, Inc., Vol. 16 Supplement. December 2009: 7–9. SIRS Researcher. Web. 25 Oct 2010.
[edit] References
- ^ Michael Powers, "Performance-Enhancing Drugs" in Joel Houglum, in Gary L. Harrelson, Deidre Leaver-Dunn, "Principles of Pharmacology for Athletic Trainers", SLACK Incorporated, 2005, ISBN 1-55642-594-5, p. 330
- ^ 7556805.
- ^ 16606610.
- ^ 1917226.
- ^ c Hartgens and Kuipers (2004), p. 515
- ^ http://acb.rsmjournals.com/cgi/pmidlookup?view=long&pmid=12880534.
- http://rphr.endojournals.org/cgi/content/full/57/1/411.
- ^ 7817189.
- ^ 11176375.
- ^ David K, Dingemanse E, Freud J, Laqueur L (1935). "Uber krystallinisches mannliches Hormon aus Hoden (Testosteron) wirksamer als aus harn oder aus Cholesterin bereitetes Androsteron". Hoppe Seylers Z Physiol Chem 233 (5–6): 281. doi:10.1515/bchm2.1935.233.5-6.281.
- ^ Butenandt A, Hanisch G. (1935). "A Method for Preparing Testosterone from Cholesterol". Chemische Berichte 68: 1859.
- ^ Ruzicka L, Wettstein A (1935). "Sexualhormone VII. Uber die kunstliche Herstellung des Testikelhormons. Testosteron (Androsten-3-one-17-ol.)". Helvetica Chimica Acta 18: 1264. doi:10.1002/hlca.193501801176.
- ^ ISBN 0-415-28030-3, page 6
- ^ 0-7864-1128-7.
- 16510635.
- ^ Justin Peters The Man Behind the Juice, Slate Friday, Feb. 18, 2005, Accessed 29 April 2008
- ^ Hartgens and Kuipers (2004), p. 516
- ^ ISBN 0-07-145153-6, p. 674–676
- ^ 17931410. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2131752/.
- 11366379.
- 16641486. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2242507/.
- 16238547. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1276946/.
- 15352158.
- ^ 9593936.
- 8855787.
- 2199753.
- 12960001.
- 16424293.
- 16540931.
- 10710012.
- http://rphr.endojournals.org/cgi/content/full/57/1/411.
- ^ L.G. Hershberger, E.G. Shipley, R.K. Meyer, Myotropic activity of 19-nortestosterone and other steroids determined by modified levator ani muscle method, Proc. Soc. Exp. Biol. Med. 83 (1953), 175–180
- ^ c Hartgens and Kuipers (2004), p. 519-527
- ^ b Hartgens and Kuipers (2004), p. 528
- http://linkinghub.elsevier.com/retrieve/pii/S0140-6736(76)90001-5.
- 7018798.
- ^ 8637535.
- 11701431.
- 14609147.
- ^ Tokar, Steve (February 2006). "Liver Damage And Increased Heart Attack Risk Caused By Anabolic Steroid Use". University of California – San Francisco. http://www.medicalnewstoday.com/medicalnews.php?newsid=38069. Retrieved 2007-04-24.
- ^ "DailyMed: About DailyMed". Dailymed.nlm.nih.gov. http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=3607. Retrieved 2008-11-03.
- 1586105.
- 8821428.
- ^ Hartgens and Kuipers (2004), p. 543
- 17274777.
- http://linkinghub.elsevier.com/retrieve/pii/S002604950300060X.
- 779604.
- ^ Hoffman JR, Ratamess NA (June 1, 2006). "Medical Issues Associated with Anabolic Steroid Use: Are they Exaggerated?" (PDF). Journal of Sports Science and Medicine. Archived from the original on 20 June 2007. http://www.jssm.org/vol5/n2/2/v5n2-2pdf.pdf. Retrieved 2007-05-08.
- 12185103.
- ^ 2104626.
- 2991700.
- 14576190.
- 11927236.
- 10499702.
- 9778553.
- 1829849.
- 9113423.
- 4079743.
- 15984895.
- ^ 18599224. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2646607/.
- 12230967.
- ^ Hartgens and Kuipers (2004), p. 514–515
- 12938869.
- 16356691.
- ^ Pat Lenehan, "Anabolic Steroids: And Other Performance-enhancing Drugs", CRC Press, 2003, ISBN 0-415-28030-3, page 23
- 15660958.
- http://www.ajph.org/cgi/pmidlookup?view=long&pmid=18923108.
- 8969015.
- 8855834.
- http://archpsyc.ama-assn.org/cgi/content/full/57/2/133. Retrieved 2007-04-24.
- 16529916.
- 12762541.
- ^ "Teens & Steroids: A Dangerous Mix". CBS (CBS Broadcasting Inc.). 2004-06-03. Archived from the original on 10 July 2007. http://www.cbsnews.com/stories/2004/06/03/eveningnews/main620967.shtml. Retrieved 2007-06-27.
- 1551042.
- http://linkinghub.elsevier.com/retrieve/pii/S0031-9384(04)00350-6.
- http://jcem.endojournals.org/cgi/content/full/86/11/5108.
- 2429792.
- 16540931.
- 8970686.
- 9329341.
- 8996996.
- 11320105.
- 17824721.
- 11730258.
- 17050889.
- 17403329.
- 17367445.
- 9497881.
- 10619981.
- http://jcem.endojournals.org/cgi/content/full/88/8/3467.
- 18514731.
- 8355384."
- 17512138. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2383927/.
- http://www.medscape.com/viewarticle/533461. Retrieved 2007-04-24.
- http://www.mja.com.au/public/issues/mar16/copeland/copeland.html.
- ^ Eastley, Tony (January 18, 2006). "Steroid study debunks user stereotypes". abc.net.au. http://www.abc.net.au/am/content/2006/s1550328.htm. Retrieved 2007-04-24.
- 15317640.
- 16585446.
- 2199753.
- ^ "Title 21 United States Code (USC) Controlled Substances Act". US Department of Justice. Archived from the original on 1 August 2009. http://www.deadiversion.usdoj.gov/21cfr/21usc/844.htm. Retrieved 2009-09-07.
- ^ "Controlled Drugs and Substances Act". Canada Department of Justice. http://laws.justice.gc.ca/en/ShowFullDoc/cs/C-38.8//20070425/en?command=home&caller=SI&fragment=anabolic&search_type=all&day=25&month=4&year=2007&search_domain=cs&showall=L&statuteyear=all&lengthannual=50&length=50. Retrieved 2007-04-25.
- ^ Deacon, James (2). "Biceps in a bottle". Maclean's: 52.
- ^ "Steroids". Australian Institute of Criminology. 2006. Archived from the original on 2007-04-05. http://web.archive.org/web/20070405033442/http://www.aic.gov.au/research/drugs/types/steroids.html. Retrieved 2007-05-06.
- ^ "Library of congress search". Library of congress. http://www.glin.gov/search.action?searchDetails.andSubjectTerms=true&searchDetails.hitsPerPage=10&searchDetails.includeAbstractFields=false&searchDetails.includeAllFields=true&searchDetails.includeNameFields=false&searchDetails.includeNumberFields=false&searchDetails.includeTitleFields=false&searchDetails.issuanceDateFrom=&searchDetails.issuanceDateTo=&searchDetails.offset=0&searchDetails.publicationDateFrom=&searchDetails.publicationDateTo=&searchDetails.publicationJurisdictionExclude=false&searchDetails.publicationLanguage=&searchDetails.queryString=steroid&searchDetails.queryType=ALL&searchDetails.searchAll=true&searchDetails.searchJudicialDecisions=false&searchDetails.searchLaws=false&searchDetails.searchLegalLiterature=false&searchDetails.searchLegislativeRecord=false&searchDetails.showSummary=true&searchDetails.sortOrder=default&searchDetails.subjectTerm=%5B%5D&searchDetails.subjectTerms=&searchDetails.summaryLanguage=&searchDetails.activeDrills=&searchDetails.offset=0&showSummary=true&refineQuery=anabolic&refineQueryType=ALL&refine=Refine+Search. Retrieved 2007-05-06.
- ^ "News from DEA, Congressional Testimony, 03/16/04″. http://www.usdoj.gov/dea/pubs/cngrtest/ct031604.html. Retrieved 2007-04-24.
- ^ http://es.fifa.com/mm/document/afdeveloping/medical/50/29/56/fifadocregulations_09.01.09_e.pdf
- ^ "Olympic movement anti-doping code" (PDF). International Olympic Committee. 1999. http://www.medycynasportowa.pl/download/doping_code_e.pdf. Retrieved 2007-05-06.
- ^ "The nba and nbpa anti-drug program". NBA Policy. findlaw.com. 1999. http://news.findlaw.com/legalnews/sports/drugs/policy/basketball/index.html. Retrieved 2007-05-06.
- ^ "NHL/NHLPA performance-enhancing substances program summary". nhlpa.com. Archived from the original on 2 June 2007. http://www.nhlpa.com/PerformanceEnhancing/index.asp. Retrieved 2007-05-06.
- ^ "List of Prohibited Substances" (PDF). nflpa.com. 2006. http://www.nflpa.org/pdfs/RulesAndRegs/ProhibitedSubstances.pdf. Retrieved 2007-05-06.
- ^ "World anti-doping code" (PDF). WADA. 2003. Archived from the original on 7 August 2007. http://www.wada-ama.org/rtecontent/document/code_v3.pdf. Retrieved 2007-07-10.
- ^ "Prohibited list of 2005″ (PDF). WADA. 2005. http://www.wada-ama.org/rtecontent/document/summary_2005.pdf. Retrieved 2007-05-06.
- ^ "Spain's senate passes anti-doping law". Associated press (Herald Tribune). October 5, 2006. http://www.iht.com/articles/ap/2006/10/05/sports/EU_SPT_Spain_Doping.php. Retrieved 2007-05-06.
- ^ Johnson, Kevin (2006-02-20). "Italian anti-doping laws could mean 3 years in jail". USA Today. http://www.usatoday.com/sports/olympics/torino/2006-02-19-anti-doping-laws_x.htm. Retrieved 2007-05-06.
- dead link]
- ^ "Protection of health of athletes and the fight against doping" (PDF). WADA. 2006. http://www.wada-ama.org/rtecontent/document/national_laws_sports_code_legislative_part_En.pdf. Retrieved 2007-05-06.
- ^ "Anti-doping legislation in the netherlands" (PDF). WADA. 2006. http://www.wada-ama.org/rtecontent/document/Dutch_Legislation_Concerning_Doping_Jan_2007.pdf. Retrieved 2007-05-06.
- ^ "The Swedish Act prohibiting certain doping substances (1991:1969)" (PDF). WADA. 1991. http://www.wada-ama.org/rtecontent/document/National_Laws_Swedish_Act.pdf. Retrieved 2007-05-06.
- ^ Mareck U, Geyer H, Opfermann G, Thevis M, Schänzer W. Factors influencing the steroid profile in doping control analysis. J. Mass Spectrom. 43: 877–891, 2008.
- ^ Fragkaki AG, Angelis YS, Tsantili-Kakoulidou A, Koupparis M, Georgakopoulos C. Schemes of metabolic patterns of anabolic androgenic steroids for the estimation of metabolites of designer steroids in human urine. J. Steroid Biochem. Mol. Biol. 115: 44–61, 2009.
- ^ Blackledge RD. Bad science: the instrumental data in the Floyd Landis case. Clin Chim. Acta. 406: 8–13, 2009.
- ^ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 95, 393, 403, 649, 695, 952, 962, 1078, 1156, 1170, 1442, 1501, 1581.
- ^ Assael, Shaun (2007-09-24). "'Raw Deal' busts labs across U.S., many supplied by China". ESPN The Magazine. Archived from the original on 14 October 2007. http://sports.espn.go.com/espn/news/story?id=3033532. Retrieved 2007-09-24.
- http://books.google.com/?id=I7-D2jH-OJ4C&pg=PA3.
- ^ Black, Terry (1996). "Does the Ban on Drugs in Sport Improve Societal Welfare?". Faculty of Business, Queensland University of Technology. http://irs.sagepub.com/cgi/content/abstract/31/4/367. Retrieved 2007-04-24.
- http://books.google.com/?id=2w-oAl42t5cC&pg=PT183.
- http://linkinghub.elsevier.com/retrieve/pii/S0376-8716(08)00191-9.
- ^ "Steroids". National Institute on Drug Abuse. GDCADA. Archived from the original on 2007-09-11. http://web.archive.org/web/20070911222757/http://www.gdcada.org/statistics/steroids.htm. Retrieved 2007-09-13.
- ^ "The Drug Enforcement Administration's International Operations (Redacted)". Office of the Inspector General. USDOJ. http://www.usdoj.gov/oig/reports/DEA/a0719/app2.htm. Retrieved 2007-09-13.
Tygart, Travis T. "Steroids, the Media, and Youth." Prevention Researcher Integrated Research Services, Inc., Vol. 16 Supplement. December 2009: 7–9. SIRS Researcher. Web. 25 Oct 2010.
Eisenhauer, Lisa. "Do I Look OK?." St. Louis Post-Dispatch (St. Louis, MO). Nov. 7 2005: HF1+. SIRS Researcher. Web. 25 Oct 2010.
[edit] Further reading
- D. Kochakian, Charles (2000). Anabolic Steroids in Sport and Exercise. Human Kinetics. ISBN 0-88011-786-9.
- Daniels, R. C. (February 1, 2003). The Anabolic Steroid Handbook. Richard C Daniels. p. 80. ISBN 0-9548227-0-6.
- Gallaway, Steve (January 15, 1997). The Steroid Bible. Belle Intl; 3rd Sprl edition. p. 125. ISBN 1-890342-00-9.
- Llewellyn, William (January 28, 2007). ANABOLICS 2007 : Anabolic Steroid Reference Manual (6th Ed.). Body of Science. p. 988. ISBN 978-0-9679304-6-6.
- Roberts, Anthony; Brian Clapp (January 2006). Anabolic Steroids: Ultimate Research Guide. Anabolic Books, LLC. p. 394. ISBN 1-59975-100-3.
- Yesalis, Charles E. (July 2000). Anabolic Steroids in Sport and Exercise. Human Kinetics Publishers; 2nd edition. p. 493. ISBN 0-88011-786-9.
- Sigmarsson, Victor (January 15, 2007). Inside Secrets: The Bodybuilder's Guide To Buying Steroids On The Internet!. SA LABS LLC ; 2nd edition. p. 7. ISBN 978-1-4507-5402-6.
Tygart, Travis T. "Steroids, the Media, and Youth." Prevention Researcher Integrated Research Services, Inc., Vol. 16 Supplement. December 2009: 7–9. SIRS Researcher. Web. 25 Oct 2010.
[edit] External links
This article uses material from the Wikipedia article anabolic steroid, which is released under the Creative Commons Attribution-Share-Alike License 3.0.


text:
In the past three seasons, Barça's handball team have maintained an 85% win rate in official competitions
Titles won by Barça these past three seasons
2 Ligas (2010/11 and 2011/12)
1 Champions League (2010/11)
1 Copa del Rey (2009/10)
3 Lligues dels Pirineus (2009/10, 2010/11 and 2011/12)
1 Asobal Super Cup (2009/10)
2 Copes Asobal (2009/10 i 2011/12)
Analysing Barça Intersport's results this season, one can observe that Xavi Pascual's men have reached an 88.2% win rate in the six official competitions that the team have played in this season. This win rate has led Barça to three titles this season: Asobal League, Asobal Cup and Liga de los Pirineos.
45 victories in 51 matches
Barça's handball team, in the 2011/12 season, played 51 official matches. 30 of them were in the Liga Asobal, 14 in the Champions League, 3 in the Copa del Rey, 2 in the Asobal Cup, 1 in the Spanish Super Cup and 1 in the Liga de los Pirineos.
Of these 51 matches, the Azulgranas won 45. Barça lost one game in the Asobal League, against BM Atlético; three in the European competition against Zagreb, Montpellier and Copenhagen, and one in the Super Cup, also against the Madrid side.
85% win rate in the last three seasons
Barça's win rate in the last three seasons, all of them with Xavi Pascual on the bench, totals 85%.
In the 2009/11 season, Barça played 54 matches and won 48 of them, tied 2 and lost 4. The team's win rate was 88.8%.
In the following season, 2010/11, the Azulgranas played 52 matches and won 42 of them, tied 3 and lost 7. The team's win rate was 80.76%.
In total, over the past three seasons, Barça have maintained an 85.9% win rate in official matches.


text:
Stumble It!
Men's Business - a funny cowboy poem set in the Wild West by Australian poet Graeme King.
A cowboy walked into a bar and
slumped upon a stool,
he threw a large tequila down and
said: "I've been a fool!
Eliza Jane had promised me that I
would be the one -
and now I find she's walking out
with Jake the banker's son!"
A gambler drinking whisky heard
his story and was moved,
he said: "I've loved a lot of
girls, and this one thing I've proved:
They promise you a life of joy,
of love and laughs and song,
then leave - the very instant
someone better comes along!"
The guy at the piano said: "I
loved this girl in Maine,
she had a smile and figure that
would drive a man insane,
I asked the question, she said
yes, but never said 'I do'
she left me for a guy who played
guitar and fiddle, too!"
"My sweet Marie," the barman
said, "so pretty, young and clean,
we planned to make our future
somewhere west of Abilene,
I went off on a cattle drive and
left her all our dough,
she ran off with some outlaw -
they're still down in Mexico."
The Sheriff moseyed over, "Love
ain't all it's said to be,
I fell in love when I was young
and just a deputy,
I sold my horse to buy her stuff,
to dress her up in furs,
but then she wed some other guy
'cause he had bigger spurs!"
The cowboy bought them all a
drink - they toasted single life,
the guy at the piano sang about a
cheating wife,
a few drinks more and every man
inside the bar was mad,
and cursing every girl on Earth
for treating them so bad.
The bar doors slowly opened and a
pretty girl stepped in,
she batted huge black lashes and
flashed all the men a grin:
"Well, hello, boys, I'm Rita-Mae,
and I've just moved to town,"
a dozen six-guns fired at once,
and cut the woman down.
It seems she hadn't noticed that
no females were around,
they all live out on Garter Hill,
and six feet under ground,
oh yes, the West was wild, and
quite dangerous back then,
she never should have came to
Stag - the town of jilted men.
The sequel:
more of my
FUNNY POEMS here
Original pictures by Graeme King
©Kingpoetry2008 BACK to TOP
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- Please share my poetry with others


text:
At least once a week I ride by this corporate business park building, with a great big logo on the side of it. It's not a great logo either. It's not even good. In fact, it's lame. Every time I look at it, I cringe and think what could have been. That logo could have been my design.
You see, a few years ago I had an opportunity to work with this company, the very one that owns that building. I was contacted by an independent marketing consultant, who through a friend of a friend who knew I was a logo design specialist. The client was a rather prominent Southern California corporation with about eight subsidiaries under their wings. Even at the time, they were successful because of their product and not from their branding image.
So, I was contacted to see if I could meet with them and check out my availability for the project. Well, after a rather thorough run-through of their logo design needs, I thought I had hit the mother lode. Not only did they need a new corporate logo, but a complete family of logos for all eight of the subsidiaries, including a graphic standards study for corporate identity, collateral, websites and company vehicles. This was a big project and I was up for the task.
Upon returning to my studio, I went ahead and busily put together a complete estimate and proposal for the promising new project. Of course, a sudden panic sets in. That sort of nervous panic that begins when those somewhat menacing timelines appear in black & white on the page. How am I going to do this? What about my other work? I might need some help.
But, don't count your chickens before they're hatched.
I get a phone call from the marketing consultant with a few extra parameters that needed to be included in the estimate. He says they needed some ideas on how the collateral pieces could be done with some simple layouts. And before they could decide on the designer, maybe some possible ways that the logos could be tied together. Oh, and that even though they had several logos to design, that the client was very cost sensitive. Uh oh.
Really. Layouts? Logo themes? Hey, who isn't cost sensitive.
Well, my spidey-sense got triggered pretty quickly after that conversation and went into over-drive. How was I going to handle those requests and still keep my integrity? I'm not giving away the milk for free. What's to keep them from taking these suggestions and having their obviously under-qualified in-house lackey do the work? It's certainly not coming from me.
Then I got an idea. When I submitted the estimate and proposal, I included a very rough outline of the collateral items in simple line art for their reference. Nothing too specific and just vague enough to satisfy the request. Then, just as vaguely I suggested the logos could be tied together with color, graphic elements, icons, typefaces, etc.—you know, the obvious answers, but not to the point of giving it away. I then priced everything accordingly for a logo project of this size and scale and submitted it.
Almost immediately I got a response phone call from the marketing guy. He thought the design fees were too high. He thought the extras were not specific enough. He wanted to negotiate. Hmm.
I'm not above negotiating with anyone, but I've got to feel like I'm getting something out of the deal. And after much discussion and a couple more phone calls, I decided to walk away.
When the design fees started plummeting enough, I started thinking of the side of the building. When the logo finally made it on to the penthouse level for everyone to see, how would I feel? Would it be a job well done, or would I feel like I got robbed? I had a distinct sense it would be the latter.
I'm glad now I can ride my bike past that building and think of what could have been, instead of finding another route.


text:
|In a New York minute
|Written by Lincoln L. Hayes
If you were around in the winter of 2002 and majority of 2003, you may recall I worked at the old D&J Hardware as my after school job.
In college, the knowledge I gleaned working there paid off in my technical theater classes—being able to tell a claw hammer from a ball peen put me well ahead of some of my classmates. (They went to performing arts high schools. Go public education!)
I never really thought my time at D&J would really pay off more than that, but then last Wednesday happened.
I currently work at a restaurant called City Winery in SoHo ("South of Hudson," a neighborhood in Manhattan), and last Wednesday, my general manager asked for my help hanging a lighted sign in our window. I told him he would want to use some hardware so he didn't have to lock the chain in place (like a carabiner or something).
He asked me to run across the street to the hardware store and get whatever I thought would work. He also gave me the company AMEX Gold Card. A bit overkill for what turned out to be $11-worth of hardware, but whatever works, I guess.
I went over, and as I'm waiting for help, I see someone I recognize: Peter Green, an actor known for his roles of Zed in Pulp Fiction, Redfoot in Usual Suspects and most recently Jimmy McMannus in too-shortly-lived ABC series Life on Mars. I thought, "Cool! The dude who played Zed is here!" and that was about it.
Then I'm up at the counter being helped, and he says, "Excuse me, can you help me with this?" I looked at the guy behind the counter, and he helped Mr. Green and that was that. He then goes to a display of what I'd describe as light-industrial space heaters. You know, like the ones farmers have in the shops by their work benches. My dad'll know what I'm talking about...
Anyway, again he turns to me and says, "Can you help me with this?" I said, "I don't actually work here. I work across the street." He apologized, saying he mistook my black shirt and apron for the black shirt the employees of the store were wearing (though why they'd be wearing aprons with City Winery printed on them is beyond me).
I said, "No problem," and after I minute I added, "Loved your work on Life on Mars. Great show, though way too short-lived. And you had a great story arc." He thanked me and agreed, then we went about our business again.
Another minute later, he said, "Would you happen to know anything about these?" I said, "Well, I did used to work in a hardware store..."
I then proceeded to talk him out of buying the $70 space heater he was thinking of buying for his mother to heat her drafty bedroom (awwww), and that he could probably get something cheaper and more effective at Staples or Office Depot because all he needed was one of those "under the desk" jobbers.
He thanked me, shook my hand and introduced himself. I told him my name, said "You're welcome," and he left.
So thank you, D&J Hardware, for giving me the appearance of knowing what I'm doing in a hardware store. I got to meet a movie star because of it.


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