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|By Marketwired .
Article Rating:
|January 16, 2013 09:32 AM EST
MONTREAL, QUEBEC -- (Marketwire) -- 01/16/13 -- Preparations are in full swing for Montreal Fashion Week Fall/Winter 2013 (MFW F/W 13), produced by Groupe Sensation Mode in collaboration with P&G Beauty & Grooming. This season, the excitement is being felt more than ever and the event has announced several new features that will rest on attributes that MFW is known for: variety and quality. This rendezvous, which brings together the fashion community, will take place February 4 to 7 at the Arsenal, a contemporary art complex.
"From edition to edition, interest in MFW is undeniable," said Jean-Francois Daviau, co-founder and co-president of Groupe Sensation Mode. "The number of people that have registered to date is very good and we are expecting more than 20,000 visitors, including fashion professionals, designers, artists and media representatives."
In addition to being a platform for Canadian designers to introduce their new collections, MFW provides a varied fashion experience and offers numerous activities, such as conferences, exhibits, artistic performances, and a new concept that marries fashion with cinema: the Fashion Premiere. This series of 21 fashion films, selected by MFW in collaboration with FAT Arts & Fashion Week Toronto and TRIPTYQUE, will be presented throughout the event and will include a tribute to RAD HOURANI directed by Parisian Jean Du Sartel. The McCord Museum will also offer two free activities dedicated to the history of fashion on February 2 and 6.
Among other firsts: MFW F/W 13 will feature a new space at the Arsenal called the Designer Studio by Target, allowing greater flexibility to designers that want to have more creative freedom and stage a non-traditional fashion show or installation with maximum impact.
For the first time, designers participating in MFW will be able to benefit from an international partnership with Russia Fashion Week, which will provide visibility in a growing market with MFW content being broadcast to influencers from the Russian fashion industry.
A large variety of designers, both established and emerging, will show their Fall/Winter 2013 collections at MFW, each representing the different facets that Canadian fashion has to offer. The designers chosen by the MFW selection committee include:
Harricana by Mariouche Nadya Toto (in collaboration with Elle Quebec) Melissa Nepton MARTIN LIM PEDRAM KARIMI (Designer Debut) by THOMAS. (Designer Debut in collaboration with Elle Quebec) Annie 50 (cocktail installation) RUSH COUTURE par/by CLAUDETTE FLOYD (in collaboration with Elle Quebec) Rachel Sin (of Toronto) Ralph Leroy (5th anniversary) COKLUCH Symbiose by hinda A. Matiere Noire Nisse BANG couture L'AUTRE COUTURE DE LUKO MARION
The "Exhibit" concept will also return this season, presenting the creations of six fashion designers:
-- Jennifer Glasgow Design -- Marilyne Baril -- Voyou -- Melow par Melissa Bolduc -- Copious Couture -- Rachel F.
Two fashion shows/special events aiming to promote Canadian talent are also planned. On February 7, Target will feature the collections of five finalists from its Emerging Designer Award. The name of the winner will be announced at the end of the fashion show.
TELIO will also present the creations of 25 finalists for "Canada's Breakthrough Designers 2013" contest, which collects entries from 22 fashion design schools across Canada.
A range of special activities has also been added to the Fall/Winter 2013 program, including a conference by Carly Stojsic of the WGSN agency, a fashion luncheon at the CIMM, the OldWIG pop-up shop, and an artistic fashion installation by Samuel Mercure that will feature live performances.
Members of the public can take advantage of exclusive access to MFW F/W 13: a four-day passport for $175, a one-day pass for $75, and single tickets for individual fashion shows priced at $25 (plus tax and service charge) are available. Tickets are on sale at www.montrealfashionweek.ca and spots are limited. Those who will not be able to get to the Arsenal can watch all of the shows live on the MFW website thanks to PARCE QUE FILMS, the official video partner.
P&G Beauty & Grooming: Proud Partner for a 16th Season
P&G Beauty & Grooming is a dedicated supporter of Montreal Fashion Week and the Canadian fashion industry as a whole. MFW is proud to have such strong and continued support from P&G, which is crucial to the continued development of our designers, both at the national and international levels.
"It is truly a privilege for P&G Beauty & Grooming to support an event with such an unparalleled roster of designers, and strong reputation, both on the Canadian and international scale," said Adema Sangale, Associate Director - Communications for Procter & Gamble Canada. "This week, a talented team of beauty experts will be using our brands, such as Pantene Pro-V, Gillette, Sebastian, Wella Professionals, Olay, and COVERGIRL, and to see our products contribute to the embodiment of Fall/Winter 2013-14 trends is truly unique and fulfilling opportunity, to say the least."
Our partners
Montreal Fashion Week is produced by Groupe Sensation Mode with the valuable support of its major partner, P&G Beauty & Grooming, as well as Target and Rowenta. International collaborators also support to the event: MELIJOE.COM, the number one online boutique for luxury children's clothing in France, and Russia Fashion Week.
Also providing continued support are the ministere des Finances et de l'Economie du Quebec, the ministere des Affaires municipales, des Regions et de l'Occupation du territoire du Quebec (MAMROT), the Montreal Fashion Bureau, Tourisme Montreal and the City of Montreal.
About Groupe Sensation Mode (GSM)
Following a decade marked by a myriad of activities, Groupe Sensation Mode continues to produce and present major fashion events in Canada and around the world. Known for its prestigious annual events such as Montreal Fashion Week and the Fashion and Design Festival, GSM has also created unique concepts such as the Fashion Theatre (on stages in Berlin, Tokyo, New York and London) and the Fashion & Opera Runway Show in Los Angeles. For the past 12 years, the innovative events organized by Groupe Sensation Mode have served as a brand, featuring the creativity and talent of designers. Thanks to partnerships established in a number of fashion capitals including Paris, Berlin and Tokyo, Groupe Sensation Mode is proud of its leadership position among the top.
For more information on Montreal Fashion Week Fall/Winter 2013, please visit: www.montrealfashionweek.ca or follow us on Facebook: www.facebook.com/SensationMode or on Twitter: @Sensation_mode (#SMM).
Valerie Marcoux / Pascale LeBlanc
Torchia Communications
514 288-8290 extensions 214 / 216
[email protected] / [email protected]
SYS-CON Events announced today that MangoApps will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. MangoApps provides modern company intranets and team collaboration software, allowing workers to stay connected and productive from anywhere in the world and from any device. For more information, please visit https://www.mangoapps.com/.
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The essence of data analysis involves setting up data pipelines that consist of several operations that are chained together – starting from data collection, data quality checks, data integration, data analysis and data visualization (including the setting up of interaction paths in that visualization). In our opinion, the challenges stem from the technology diversity at each stage of the data pipeline as well as the lack of process around the analysis.
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Many banks and financial institutions are experimenting with containers in development environments, but when will they move into production? Containers are seen as the key to achieving the ultimate in information technology flexibility and agility. Containers work on both public and private clouds, and make it easy to build and deploy applications. The challenge for regulated industries is the cost and complexity of container security compliance. VM security compliance is already challenging, ...
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Designing IoT applications is complex, but deploying them in a scalable fashion is even more complex. A scalable, API first IaaS cloud is a good start, but in order to understand the various components specific to deploying IoT applications, one needs to understand the architecture of these applications and figure out how to scale these components independently. In his session at @ThingsExpo, Nara Rajagopalan is CEO of Accelerite, will discuss the fundamental architecture of IoT applications, ...
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A strange thing is happening along the way to the Internet of Things, namely far too many devices to work with and manage. It has become clear that we'll need much higher efficiency user experiences that can allow us to more easily and scalably work with the thousands of devices that will soon be in each of our lives. Enter the conversational interface revolution, combining bots we can literally talk with, gesture to, and even direct with our thoughts, with embedded artificial intelligence, wh...
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NHL Scores
Saturday's Results
Kings 5, San Jose 2
St. Louis 2, Ducks 1, OT
Boston 4, Washington 1
Pittsburgh 3, N.Y. Rangers 0
Ottawa 4, Buffalo 3, OT
Minnesota 6, Colorado 4
Winnipeg 5, Toronto 4, SO
Montreal 2, New Jersey 1
Tampa Bay 4, Carolina 1
Columbus 1, Phoenix 0, SO
N.Y. Islanders 4, Florida 3
Chicago 8, Dallas 1
Detroit 5, Vancouver 2
Today's Games
Boston at Pittsburgh, 9:30 a.m.
Winnipeg at Ottawa, 2 p.m.
Buffalo at Washington, 4 p.m.
Nashville at Edmonton, 5 p.m.
Monday's Games
San Jose at Ducks, 7 p.m.
Phoenix at Kings, 7:30 p.m.
Carolina at N.Y. Rangers, 4 p.m.
Philadelphia at Tampa, 4:30 p.m.
Calgary at Dallas, 5:30 p.m.
Chicago at Colorado, 6 p.m.
Minnesota at Vancouver, 7 p.m.
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- Trinity Broadcasting Network co-founder Jan Crouch dies of massive stroke
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subset: commoncrawl


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MPs approve proposal to amend Municipality LawKUWAIT CITY, May 25: The National Assembly approved the proposal to amend the Municipality Law in its first deliberation on Wednesday. The amended law was referred to the Public Utilities Committee which will prepare a report before the second ... Arab Times, 3 days ago
Rio Olympics: As Kenya scrambles to amend WADA anti-doping laws, real anger is emerging - Blasting News United States, 1 day ago
Kenya passes anti-doping law amendments amid Olympic ban threat - Yahoo! News, 2 days ago
196 images for first amendment
Overseas Investors Sell Rs.178 Crore Worth Shares In 2 Weeks
Foreign investors dumped shares worth Rs 178 crore in the first two weeks of May as worries over global economy and amended Indo-Mauritius tax treaty hurt sentiment, reversing the last two months' bullish trend. In March-April, Foreign Portfolio Investors ...Silicon India, 1 week ago Overseas investors sell Rs 178 cr worth shares in 2 weeks Money Control, 1 week ago
RS panel on enemy property to hold 1st meeting tomorrow
The Select Committee of Rajya Sabha on the Enemy Property (Amendment and Validation) Bill, 2016 will hold its first meeting on Monday during which Home Secretary Rajiv Mehrishi will give a presentation. The Select Committee, headed by BJP member ...Business Standard, 2 months ago Rajya Sabha select panel may not give unanimous report Asian Age, 1 month ago Non-BJP states slam Enemy Property Bill, say it fails to recognise succession rights First Post.com, 1 month ago RS panel on enemy property Bill to submit report in 2nd part Business Standard, 2 months ago
Shashank Manohar elected unopposed as ICC's first independent Chairman
The 58-year-old was elected to the post after the ICC Full Council's approval of constitutional amendments proposed by the Board Press Trust of India | Dubai May 12, 2016 Last Updated at 11:42 IST Veteran cricket administrator Shashank Manohar was today ...Business Standard, 2 weeks ago Shashank Manohar elected ICC chairman unopposed Sify, 2 weeks ago Manohar elected unopposed as ICC's first independent Chairman Deccan Herald, 2 weeks ago India's Shashank Manohar elected as new ICC chairman Rediff.com, 2 weeks ago
Will Cabinet decision to amend Act help KSOU?
The State government has taken the first major step for restoring the lost pride of the Karnataka State Open University (KSOU) with the Cabinet on Wednesday resolving to amend the KSOU Act, 1996, for ...The Hindu, 1 month ago
IPL 2016: Delhi Daredevils vs Kings XI Punjab: Squads, date, time, venue, TV listing, live streaming
Both teams having lost their respective first games, will be looking to make amends in the crucial clash. Last Updated: Friday, April 15, 2016 - 12:16 New Delhi: Delhi Daredevils take on Kings XI Punjab in Match 7 of the Indian Premier League 2016 at the ...Zee News, 1 month ago IPL 2016: Kings XI Punjab seek to buck trend and start well against newcomers Gujarat Lions First Post.com, 1 month ago KXIP to meet Gujarat Lions today State Times, 1 month ago IPL strugglers KXIP seek positive start against Gujarat Lions State Times, 1 month ago
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485BXT - FIRST TRUST EXCHANGE-TRADED FUND VI (0001552740) (Filer)
Form 485BXT - New effective date for post-effective amendment [Rule 485(b)(1)(iii)] SEC Accession No. 0001445546-16-008634 Filing Date 2016-05-24 2016-05-24 16:29:58 Filing Date Changed 2016-05-24 Document Format Files Series ...SEC Filings, 4 days ago 487 - FIRST TRUST COMBINED SERIES 523 (0001668128) (Filer) SEC Filings, 4 days ago
BRIEF-Universal Health Realty Income Trust entered into first amendment to the credit agreement entered into on March 27, 2015
May 25 (Reuters) - * Universal Health Realty Income Trust says on May 24, 2016, entered into the first amendment to the credit agreement, entered into on March 27, 2015 * Universal Health Realty Income Trust says revolving line of credit ...Reuters UK, 3 days ago BRIEF-Leggett & Platt says enters first amended and restated credit deal Reuters UK, 1 week ago
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List all words starting with tarty
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1356 members Latest Activity: Jul 9, 2015 A group for regular (and irregular) readers of PZ Myers' blog Pharyngula.
114 members Latest Activity: Dec 1, 2015 Is anyone out there? We are surrounded by Christian Fundamentalists. Some of whom we call family. Tell us your story.
205 members Latest Activity: Dec 23, 2012 For anyone who supports the 44th President of the United States!
201 members Latest Activity: Dec 11, 2015 For the most part we photographers see the world as it truly is through the lens of a camera which is what we also strive to do as atheists and…
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Customer simple forum needed do not use template
we are looking for a customer made for can be made in html or javascript or php , please make this custom do not use joomla or wordpress, i attached the layout of what we want all the pages need to end with .html, and have "-" in between each file name , please make the color scheme match our current site mechlancedotcom that is the site the forum will go on. On the forum page basically you guys will make it then ill give the program to my programers to have them install it. Payment is half to start then once program is made we will release half then you send us the file once we install on our end and our programmers say it works then we will send the second half over.
Users can add other users as friends in this forum and send them message and post comments on peoples topics that they post , users must be a member of the forum to post topics inside categories , only the admin can make new categories.
We do want to add a log in with facebook so users can add more facebook friends to the forum
the sign in with mechlance im not sure how you would make that with out any mechlance coding just let me know what coding you need to make that and ill let my programmers know if its possible in my price range , mechlance is mainly javascript site , users can sign up with the forum without a facebook account and a mechlance account as well.
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Relevant offers
Will Ferrell said he would never participate in a sequel for any of his movies. That was until the love for Ron Burgundy became too much for the Anchorman 2 writer and star.
"The fandom for this movie just kept growing with each year and after doing so many trips to Australia promoting other movies, where, after the second question, all I'm being asked is, 'Are you going to do a sequel to Anchorman?', we thought that maybe we should really do this," Ferrell told Fairfax Media following the Australian premiere of the sequel to the 2004 sleeper hit.
It was understandable then as to why he was decidedly coy and more interested in eating a lozenge than answering, "Are the rumours about an Anchorman 2.5 true?"
"There could be a whole other movie. There are 230 jokes that you could put in and into a recut of the first movie."
Co-star David Koechner, who plays the cowboy hat wearing, catch phrase loving sports reporter Champ Kind, chimed in, "He's not joking. McKay [director and co-writer Adam McKay] has gone through it. Somebody has counted."
Such close attention to detail is not surprising.
Carefully lodged between hilarious scenes of a manic Brick Tamland (played by Steve Carell) wooing Kristen Wiig's character, Chani, and Ron bottle feeding a shark, Anchorman 2 is a subtle slap in the face to the new media and news media especially.
The film is the comedic equivalent of Aaron Sorkin's TV series, The Newsroom.
Anyone who has ever decreed, "This isn't news!" while watching or reading 'the news' will love the jokes, media bosses - not so much. The cameo list however, which boasts strong performances by Harrison Ford, Tina Fey, Jim Carrey and even Kanye West, will have mass appeal.
The original's glass case of emotion is gone. Ferrell and McKay's sequel is all about those in glass houses.
"Some people in the news world will embrace it, but I think there will be a fair amount of denial in it, saying 'We're not that bad', but yes. Yes, you are," Ferrell said.
"There will probably be tears [from real life newscasters] because the curtain has been drawn," Koechner said.
Not only does the film hold a mirror up to the mechanisations of the media, but it is also revolutionising the way movies are promoted. The strategic yet savvy Australian marketing activities are proof of this. Each of the special YouTube videos starring Ron Burgundy released in time for the federal election, AFL grand final and Melbourne Cup all went viral.
"This has been the most comprehensive amount of material I've ever participated in," Ferrell told industry magazine Adweek.
For all the innovation behind the scenes, the final Anchorman 2 product is set in the early '80s and shows just how far Ron, Veronica and the entire Channel 4 news team have come. The days of "Panda Watch" in San Diego are long gone. They are a ratings phenomenon in New York after being hired by Australian mogul and Koala Airlines owner, Kench Allenby (played by Australian actor Josh Lawson), at his new 24-hour news service.
After smoking crack on live TV and investigating the "greatest human mystery that is the vagina", they are swiftly promoted by the Murdoch-esque Allenby to prime time at the station which bears an uncanny resemblance to the real life Fox News network.
"We loved paying homage to one Mr Ronald Murdoch," Ferrell said as Koechner, Carell and Rudd smirked and nodded.
"Ah, it's Rupert Murdoch. His name is Rupert," a minder interjected as our interview came to an end.
"I know, that was the joke," Ferrell replied.
Anchorman 2 opens in cinemas on December 19.
- Sydney Morning Herald
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Native American leader: Reservations offer mission field in plain sight
- March 29, 2016
- By C.C. Risenhoover / Special to the Baptist Standard
Indian reservations are home to some of the highest substance abuse rates in the United States, but a Native American Christian leader believes they could become the seedbed for the nation's next great spiritual revival.
Overcome critics with kindness, Tyler's Dykes urges Christians
- March 25, 2016
- By Andrew J.W. Smith / Southern Seminary
"You may create enemies because of your position, but you should never create enemies because of your disposition," insisted David Dykes, pastor of Green Acres Baptist Church in Tyler.
David Crosby to be nominated for SBC president
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- By David Roach / Baptist Press
Pastor David Crosby of New Orleans will be nominated for president of the Southern Baptist Convention, former SBC President Fred Luter said.
Supreme Court hears arguments regarding contraceptive mandate accommodation
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The Supreme Court considered arguments in a case that challenges the accommodation procedure religious nonprofits can use to opt out of the Affordable Care Act's contraceptive coverage mandate.
TBM continues disaster relief in flooded areas of East Texas
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Around the State: HPU health fair, Baylor nursing school ranks high
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- By Staff / Baptist Standard
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Minister protests execution in Huntsville during Holy Week
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International study reveals gender gap in religion
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IMB: Decreased baptisms and church starts due to record-keeping changes
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- By David Roach / Baptist Press
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Obituaries: David Becker and Alice Frost
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- By Staff / Baptist Standard
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TONS of top BJJ practioners use the spider guard as their primary form of guard from the bottom. This position has won many BJJ tournaments, from local competitions to the Mundials. And although you'd think that these champions would be completely lost in no gi submission grappling competitions like ADCC that's usually just not the case. Even though there aren't any sleeves or collars to hold … [Read more...]
11 Short MMA Conditioning Workouts by Chuck Liddell's Coach John Hackleman
John Hackleman is a friend of Grapplearts and a very successful MMA coach. He runs The Pit Gym and guided Chuck Liddell to UFC Lightweight Champion status and has coached many other MMA fighters. As an MMA trainer he is keenly aware of the importance of conditioning for fighters, but also for 'regular' people training martial arts for self defense. Hackleman is also a very direct … [Read more...]
The 2 Easiest Takedowns for No Gi Submission Grappling and MMA
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Top 10 Throws and Takedowns for BJJ
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Flying Armbar Guard Pull
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How to Pass the Leg Lasso in Spider Guard
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How to Counter the Toreando Guard Pass
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Help us to be there for older people in Wales
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Our new vision
Source : Age Cymru
Published on 25 January 2012 03:30 PM
Each week this winter we're publishing a simple health tip to help older people in Wales keep warm, safe and well.
This week Joanne Bass, our Keep Well this Winter Coordinator offers advice on saving energy.
Joanne says:
"Make sure you're saving energy wherever you can.
"Things you can do to save energy include switching off appliances rather than leaving them on standby, replacing normal lightbulbs with energy efficient bulbs which use one fifth of the electricity, and only boiling as much water as you need in the kettle."
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In a year overflowing with remakes, "Insomnia" was one of the lucky few to make a significant impact with critics and audiences.
In a year overflowing with remakes, "Insomnia" was one of the lucky few to make a significant impact with critics and audiences.
Despite being shut out of the foreign-lingo Oscar category, "Talk to Her" shouldn't be counted out of the upcoming kudos races.
The Slamdance 2003 Film Festival has invited 15 features to compete at its ninth annual event from a record 2,800 submissions. Slamdance runs Jan. 18-25 in Park City, Utah.
Last year's "The Lord of the Rings: The Fellowship of the Ring" proved Oscar gold was no fantasy for director Peter Jackson and his colleagues.
One of the great film success stories of 2002, the sexy, sad and politically charged Mexican road pic "Y tu mama tambien" (And Your Mother Too) can't compete in the foreign-lingo race.
The Academy of Motion Picture Arts & Sciences often smiles on well-liked thesps who do good work behind the camera. Usually, best pic wins come for B.O.-busting blood-sweat-and-tears epics (Mel…
It certainly wasn't the first time Steven Spielberg took the science fiction route, but this time he had the world's most bankable star at his disposal: Tom Cruise.
In only its second year of existence, the category of animated feature is offering up one of the hottest Oscar races, with consideration ads in toon buff magazines and heavy PR activity already…
"8 Mile" is the cultural intersection where Hollywood studio filmmaking meets hip-hop's inner-city origins, and where Eminem has entered the movie star fast lane.
When "My Big Fat Greek Wedding" opened April 19, expectations were as modest as the production itself.
After homering with "The Rookie," Disney and producers Gordon Gray and Mark Ciardi are tackling the gridiron with "Fourteen Feet."


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for just an hour,
while twilight titillates the wolves
and dusk drops the last of her clothes
to bare her blackened soul,
for just an hour, 228 more words
Tags » Introspection
The Most Stressful Yoga Class Ever
Before I get into this yoga class – life updates! As per usual, it's been a while. Is personal blogging even trendy anymore? Isn't it about Tumblr and Twitter and Instagram now? 912 more words
We must not forget to look down and admire the wildflowers, on our pursuit to conquer our destinies.
It is often as maddeningly frustrating to carry on with everyday activities as it can be to gather the courage to begin them. Amidst the frustration of finding one's purpose in the universe, an existential cry determinedly taunts and tortures until its message becomes irritatingly profound: " 727 more words
An Anger Problem
We are taught as a society that anger is bad. Angry children are punished instead of taught to process, angry men are destructive, and angry women are irrational. 231 more words
the things you make
It's May 21st. I'm standing in front of a little stage, tucked into a corner of a commercial building turned residential art collective space, and I am overcome with wonder. 322 more words
Speaking Truth, Husbandically: Revolutionary IMprov HaikuKuhns
Before and After: Introspection FAIL
In about 30 minutes, I have an informal job interview with a consulting firm. They're working with a client who they feel would benefit from my industry experience. 338 more words


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Katy's Typhoon Texas waterpark opens Memorial Day weekend
Longhorns legend Ricky Williams to run marijuana friendly gym
From the sky, this San Antonio-area sinkhole looks like an abyss
Kelly Ripa says she got 'symbol of my stupidity' tattoo in San...
Man, woman accused in April homicide
Jose Canseco's daughter, Josie, 19, poses bottomless for Playboy
Texas state park posts bloodcurdling photo and video of a...
Austin police still searching for suspects after 83...
South Texas police discover 'arsenal' of weapons, body armor...
Photos show 7 Central Texas lakes filling up after 2015-2016...
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Vampire bats feed on S.A. man, pals
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Man killed as car plows into home ID'd
A man who died after a car crashed into his home and ignited a fire has been identified, KSAT-TV reports. John Cardenas, 88, died Sunday morning after the car plowed into his home in the 4200 block of …
Entire UT campus evacuated amid threat
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Grandma dragged from car by cop
A North Texas police department is standing by an officer who dragged a 77-year-old grandmother out of her car after he stopped her for speeding and she repeatedly refused to give him her driver's …


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The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence
Oncogene-induced senescence is an anti-proliferative stress response program that acts as a fail-safe mechanism to limit oncogenic transformation and is regulated by the retinoblastoma protein (RB) and p53 tumor suppressor pathways. We identify the atypical E2F family member E2F7 as the only E2F transcription factor potently up-regulated during oncogene-induced senescence, a setting where it acts in response to p53 as a direct transcriptional target. Once induced, E2F7 binds and represses a series of E2F target genes and cooperates with RB to efficiently promote cell cycle arrest and limit oncogenic transformation. Disruption of RB triggers a further increase in E2F7, which induces a second cell cycle checkpoint that prevents unconstrained cell division despite aberrant DNA replication. Mechanistically, E2F7 compensates for the loss of RB in repressing mitotic E2F target genes. Together, our results identify a causal role for E2F7 in cellular senescence and uncover a novel link between the RB and p53 pathways.
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[Show abstract] [Hide abstract] ABSTRACT: The fundamental biological importance of the Tp53 gene family is highlighted by its evolutionary conservation for more than one billion years dating back to the earliest multicellular organisms. The TP53 protein provides essential functions in the cellular response to diverse stresses and safeguards maintenance of genomic integrity, and this is manifest in its critical role in tumor suppression. The importance of Tp53 in tumor prevention is exemplified in human cancer where it is the most frequently detected genetic alteration. This is confirmed in animal models, in which a defective Tp53 gene leads inexorably to cancer development, whereas reinstatement of TP53 function results in regression of established tumors that had been initiated by loss of TP53. Remarkably, despite extensive investigation, the specific mechanisms by which TP53 acts as a tumor suppressor are yet to be fully defined. We review the history and current standing of efforts to understand these mechanisms and how they complement each other in tumor suppression.
- "Cellular senescence is a distinct cell state involving permanent cell-cycle arrest of cells that remain viable and metabolically active , which is characterized by a discrete transcriptional profile (Shay and Roninson 2004). The TP53 protein controls cellular senescence by activating a number of transcriptional targets that include Cdkn1a, Pml, Pai1, and E2f7 (Pearson et al. 2000; Kortlever et al. 2006; Aksoy et al. 2012 ), some of which (e.g., Cdkn1a) are notable for additional function in cell-cycle regulation . Senescence is often associated with, and is thought to suppress, premalignant lesions preventing their progression to overt malignancy (Collado et al. 2005; Mooi and Peeper 2006). "
[Show abstract] [Hide abstract] ABSTRACT: E2F transcription factors control the oscillating expression pattern of multiple target genes during the cell cycle. Activator E2Fs, E2F1–3, induce an upswing of E2F targets, which is essential for the G1-to-S phase transition, whereas atypical E2Fs, E2F7 and E2F8, mediate a downswing of the same targets during late S, G2, and M phases. Expression of atypical E2Fs is induced by E2F1–3, but it is unknown how atypical E2Fs are inactivated in a timely manner. Here, we demonstrate that E2F7 and E2F8 are substrates of the anaphase-promoting complex/cyclosome (APC/C). Removal of CDH1, or mutating the CDH1-interacting KEN boxes, stabilized E2F7/8 from anaphase onwards and during G1. Expressing KEN mutant E2F7 during G1 impairs S phase entry and eventually results in cell death. Furthermore, we show that E2F8, but not E2F7, interacts also with APC/CCdc20. Importantly, atypical E2Fs can activate APC/CCdh1 by repressing its inhibitors cyclin A, cyclin E, and Emi1. In conclusion, we discovered a feedback loop between atypical E2Fs and APC/CCdh1 , which ensures balanced expression of cell cycle genes and normal cell cycle progression. Keywords anaphase-promoting complex; CDH1; cell cycle
- "This regulatory mechanism is most likely important during late S, G2, and M phases to coordinate the downregulation of E2F target genes. In addition, it might be also relevant during DNA damage, because previous studies have shown that E2F7/8 expression increases during DNA damage434445 and APC/C Cdh1 activity becomes reactivated in G2 cells with DNA damage [46,47]. Further support for an APC/C Cdh1 -E2F feedback loop is provided by the fact that the Emi1-encoding gene FBXO5 and the CDK2-activating genes CCNA2 and CCNE1/2 are known target genes of the activator E2F1–3 [33,48,49]. "
- "Why some WD/DDLS cells undergo senescence and others do not following CDK4 inhibition was not clear. We were unable to link this to the activity of SCF skp2 , the accumulation of p21 or E2F7, the expression of p300 or twist, or the accumulation of DNA damage, telomere attrition, or production of ROS, all well established inducers of senescence whether p53 dependent or independent171819 50]. Because senescence is a preferred outcome of cell cycle exit induced by chemotherapy, and CDK4 inhibitors have achieved Breakthrough Therapy Designation from the FDA and have had some success in treating patients with WD/DDLS, it seemed important to understand this. "
MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition[Show abstract] [Hide abstract] ABSTRACT: CDK4 inhibitors (CDK4i) earned Breakthrough Therapy Designation from the FDA last year and are entering phase III clinical trials in several cancers. However, not all tumors respond favorably to these drugs. CDK4 activity is critical for progression through G1 phase and into the mitotic cell cycle. Inhibiting this kinase induces Rb-positive cells to exit the cell cycle into either a quiescent or senescent state. In this report, using well-differentiated and dedifferentiated liposarcoma (WD/DDLS) cell lines, we show that the proteolytic turnover of MDM2 is required for CDK4i-induced senescence. Failure to reduce MDM2 does not prevent CDK4i-induced withdrawal from the cell cycle but the cells remain in a reversible quiescent state. Reducing MDM2 in these cells drives them into the more stable senescent state. CDK4i-induced senescence associated with loss of MDM2 is also observed in some breast cancer, lung cancer and glioma cell lines indicating that this is not limited to WD/DDLS cells in which MDM2 is overexpressed or in cells that contain wild type p53. MDM2 turnover depends on its E3 ligase activity and expression of ATRX. Interestingly, in seven patients the changes in MDM2 expression were correlated with outcome. These insights identify MDM2 and ATRX as new regulators controlling geroconversion, the process by which quiescent cells become senescent, and this insight may be exploited to improve the activity of CDK4i in cancer therapy.


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Save an average of $37 with 3 coupon codes & deals for warmyourfloor.com. Welcome to Warm Your Floor, the nation's leading radiant heat, electric floor heating resource. We have the largest inventory of electric radiant floor products in the U.S., in stock and ready for immediate delivery, from the leading electric floor heating manufacturers at the best prices. Most importantly, we're passionate about adding warmth to your home from the ground up. We'll help you determine which electric floor heating product is right for your specific application. Send us your room layout and we'll design and quote a floor heating system especially for you. Let us help you and your family begin enjoying the comfort of a warmer floor!
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|By Marketwired .
Article Rating:
|March 26, 2014 09:01 AM EDT
NEW YORK, NY -- (Marketwired) -- 03/26/14 -- Conductor, the global leader in search technology, today announced the release of Content Insights powered by Adobe Analytics for the Conductor Searchlight platform. For the first time, marketers and agencies can unlock the full potential of their content strategy by combining their content marketing activities with their Adobe Analytics performance.
"The next generation integration of Adobe Analytics with Conductor's Searchlight Content Insights is a significant step in the growth and evolution of our content-first approach, and reinforces our dedication to the Adobe Marketing Cloud," says Seth Besmertnik, CEO.
Baruch Toledano, Conductor's Vice President of Product, led the company's efforts to create the Adobe Certified integration. "We're very excited to partner with Adobe and further extend the capabilities of Searchlight," said Toledano. "One of the great product challenges with the new integration has been creating a simple and flexible user experience, while unlocking the power of Adobe Analytics. We built this integration to provide flexibility for users to report on content performance and discover content opportunities using metrics that are most important to their businesses."
Key capabilities include:
- Seamlessly and securely import traffic, conversion and revenue information using a simple, clean and intuitive interface.
- Display and trend any imported metric within Content Insights for comprehensive content analysis and relative importance of content to site as a whole.
- Create and measure content using common business groupings such as products, brands, channels, content authors, and site structure. Content segments can be updated with no dependency on IT internal resources.
- Dynamic content segment membership that can be retroactively applied to prior campaigns.
Conductor was the first Adobe accredited SEO partner to bring analytics-powered SEO to digital marketers with the integration of Adobe Analytics in 2011. Since then, Conductor has successfully deployed hundreds of integrations for the world's leading marketers.
Content Insights powered by the Adobe Marketing Cloud is now fully available to Searchlight customers. For more information on Content Insights visit: conductor.com/contentinsights.
About Conductor
Conductor is the undisputed leader in SEO technology, empowering enterprise marketers to manage and improve their SEO efforts and deliver provable ROI. The company created the first and most widely adopted, cloud-based SEO platform, Conductor Searchlight, which helps marketers scale natural search, monitor competitive market share and boost revenue. Through innovations like the SEO Cloud, Conductor makes it possible for organizations to blend SEO data and workflow across any other form of web marketing. Companies such as FedEx, Siemens, Best Buy, and GE rely on the company's technology platform and team of experts to continually measure and improve their natural search traffic and revenue.
Based in New York City, Conductor has been named one of Crain's Best Places to Work in New York for the third consecutive year and was ranked the 13th fastest-growing software company by Inc. Magazine.
Visit Conductor at www.conductor.com or on Twitter @conductor
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Cloud cascade scarves
Scallop Crochet Scarf
My very first project :)
Star Bowl
Happy Baby Blanket
Best Bunny, lovely when finished I did...
Bedspread (Full size)
suede bag
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Braided Scarf
This didn't look nearly as gaudy as...
Fresh Picked 3/4 Sleeve Cropped Sweater
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Black fuzzy hat!
Black & Red Martha Poncho
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