text:
Relevant offers
Former Australian cricketer Shane Warne has showed off his romantic side by posting a series of reflective quotes on Twitter.
Warne and fiancee Liz Hurley have been avoiding questions regarding their relationship status since admitting in September that they were "sorting through some issues".
Speculation their romance was over was rife after Hurley failed to tweet a happy birthday message to Warne on his 44th birthday on September 13.
The pair, usually prolific tweeters, had not communicated with each other on social media for a number of weeks, leading to speculation their romance was over.
Now in a sign that the couple have been working hard to repair their relationship, Warne has taken to Twitter to reflect.
"There comes a time when all of us have to choose between turning the page or closing the book !!" Warne tweeted.
There comes a time when all of us have to choose between turning the page or closing the book !!
— Shane Warne (@warne888) November 25, 2013
Sometimes, two people have to fall apart to realize how much they need to fall back together.
— Shane Warne (@warne888) November 25, 2013
Warne and Hurley, 48, have been engaged for two years.
The cricketer is currently in Australia to cover the Ashes Test series for the Nine Network.
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Press Room
Association News
Jul 20, 2013
September 23 is the effective date of the National Credit Union Administration's final rule on loan...
Jul 15, 2013
The nomination of former Oregon State Senator Richard Metsger (D) will be voted upon at a hearing...
Jul 12, 2013
Mortgage regulations and nonbank supervision are two of many current Consumer Financial Protection...
Jul 12, 2013
Financial institutions, including credit unions that are required to execute reporting requirements...
Jul 8, 2013
A review of the National Credit Union Administration's recently proposed derivatives rule is one of...
Jul 8, 2013
NCUA's Office of Small Credit Union Initiatives is accepting grant applications until July 12, 2013.
Jul 7, 2013
House Oversight & Government Reform Chairman Darrell Issa (R – CA 49) has called on U.S. Health...
Jul 7, 2013
Credit unions have to be in compliance with the new loan participation rules by September 23.
Jul 1, 2013
Amendments to the Uniform Commercial Code (UCC) Article 9 take effect July 1, 2013.
Jul 1, 2013
The NCUA's amended and long-awaited loan participation rule was approved Thursday, June 20, at the...
CU News
Oct 8, 2015
Credit Union Honored for Creating Outstanding Workplace Environment
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The goal of the Fit to Lead program is to institutionalize a culture of health, fitness and...
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Christmas in April is a non-denominational volunteer organization that repairs the homes of senior...
Oct 7, 2015
Credit Unions mourn the loss of Miriam Rivera Lieb Vellek, former CEO of Transportation Federal Credit Union
Update to story - memorial service details included.
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Donations can be made at any of the Credit Union's branch locations between October 9 and December...
Oct 7, 2015
Three individuals and one program to receive CU's highest honors.
Oct 7, 2015
Donation campaign launched in conjunction with anniversary.
Oct 6, 2015
Credit Union Foundation MD|DC proudly presents Motown, The Musical, on March 13.
Oct 2, 2015
Steve Arbaugh, CFO and SVP of Finance at SECU has been elected to the governing board of trustees...
Oct 1, 2015
Sharonne Bonardi, a member of the Board of Directors of SECU, has been named Deputy Comptroller by...
RSS News
Jan 26, 2015
CUNA joined with a group of financial trade organizations in a letter to Congress seeking a set of...
Jan 26, 2015
Goldenwest CU, Ogden, Utah, with $1 billion in assets, has initiated a member advocacy group that...
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No news found.

subset: commoncrawl


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text: Video: Canadian Jesus Christ Superstar heads to Broadway Add to ... The Globe and Mail Published Wednesday, Oct. 05, 2011 4:03PM EDT Last updated Wednesday, Oct. 05, 2011 4:04PM EDT A Canadian production of the classic musical "Jesus Christ Superstar" is making its way to Broadway. Paul Nolan, who plays the title role, says he is amazed at the broad spectrum of fans the show has attracted. Watch More Video: Sam Claflin and Emilia Clarke get up close and personal in 'Me Before You' Author Meg Rosoff receives Astrid Lindgren Memorial Award Chinese company apologizes for offensive TV commercial 'X-Men: Apocalypse' tops box office, but Depp's 'Alice' bombs How French singer Vincent Niclo is wooing new fans with 'Romantique' Johnny Depp's daughter disputes abuse allegations New Winnie-the-Pooh story celebrates the Queen's 90th birthday French artist completely transforms Louvre's pyramid entrance Personal belongings of Marilyn Monroe put up for auction in London How Kunal Nayyar turned up in a Justin Timberlake music video Urinal replaces Donald Trump's 'potty mouth' in Winnipeg nightclub CTV Toronto: Beyonce, Selena Gomez hit the stage Our theatre critic shares his best bets for this year's Stratford Festival Allison Janney speaks out on wage inequality in Hollywood How David Schwimmer found his inner restaurateur for 'Feed the Beast' ShowBiz News: Cosby's lawyers outline defense case in sex-assault trial The Tragically Hip announce dates for upcoming summer tour 'My body is not an obscenity': Japanese creator of vagina art speaks out Who has Neil Young's support in the U.S. presidential election? ShowBiz News: Bill Cosby back in court for sex-assault case Comments AA More Related to this Story Stratford's Jesus Christ Superstar gets two Tony nominations Video: Seana McKenna's gender-bending hunchback Video: J. Kelly Nestruck's Stratford preview


text:
Watch Featured Movies
Cujo: A friendly St. Bernard named "Cujo" contracts rabies and conducts a reign of terror on a small American town.
|IMDB: 6.0/10 Metascore: N/A RT: 59%
|August 10, 1983
|93 mins
|Horror Thriller
|Lewis Teague
|Arthur Rosenberg Billy Jayne Christopher Stone Clare Nono Daniel Hugh Kelly Danny Pintauro Dee Wallace Ed Lauter Jerry Hardin Kaiulani Lee Mills Watson Robert Behling Robert Craighead Robert Elross Sandy Ward
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|Posted by robchar 1 year, 2 months ago
this was my first time watching this one got to say another classic done by Stephen King. They did an all around great job for everything for its time. 5/5
|Posted by TaureDawn 1 year, 6 months ago
Such a scary film - and dog! Love this classic horror flick! 9/10
|Posted by Hellbound999 2 years ago
I just watched this movie for the first time since the nineties and i must say what an underrated movie it really is! It is brilliantly crafted and the dog's "acting" was absolutely fantastic! The trainers did a fantastic job making Cujo look rabid. What patience the dog must have had having all that slimy goo all over him. There were moments where it looked real especially when the little boy was crying. I would bet that he was scared to death and his tears were real. (poor little guy) Well made movie. 8/10
|Posted by IAmMe55455 2 years, 5 months ago
This is a fantastic Stephen King movie. 10/10 easily.
|Posted by becky9541 2 years, 6 months ago
I love this movie!! Amazing horror dog movie. I also remember Atomic Dog as a kid but it doesn't have any links to it on this site. Anyone know where to watch Atomic Dog 1998? Please message me. Thank you :) http://www.primewire.ag/watch-153180-Atomic-Dog
|Posted by purplewitch218 2 years, 8 months ago
one of my Stephen King favorites.. I watched this many times growing up. It was just as thrilling now as it was then. Will be watching again!! 5/5
|Posted by poppinpaula 2 years, 8 months ago
This movie scared me. I never looked at a big,mangy looking dog the same.
|Posted by Elsabern 2 years, 9 months ago
I saw this movie as a teenager but here today to watch it a second time
|Posted by 0reaver0 3 years, 6 months ago
this film gave me nightmares when i saw it at age 7 i was scared of dogs for a while lol 7/10 worth a watch
|Posted by mikey84 3 years, 7 months ago ( Edited 2 years, 7 months ago )
Classic! a must watch if you haven't seen. And the book is an excellent read. 9/10
|Posted by lavalishus 3 years, 8 months ago
if anybody els is looking for a good clasic,this is the right movie!! its my first time watching it in 2012 and i loved it :D
|Posted by elvis1968 3 years, 8 months ago
love it.. one of kings best
|Posted by KissesfromBoston 4 years, 1 month ago ( Edited 4 years, 1 month ago )
Another Stephen King Classic. I do not get tired off watching Cujo. This movie makes me get my dog's rabies shot every year!! 5/5 Stars.
|Posted by NathalieGER 4 years, 1 month ago
Loved that movie! A S.King classic, if you ask me. It was made very easy and looks kind of low budget, but that is the most amazing thing about this film: It is creepy although it is made so easily. Really creeped me out, and I usually don't get scared of dogs so easily. I give it a 8.5 out of 10.
|Posted by tessie86 5 years, 6 months ago
i loved this movie...this is a reason u should give ur dog shots..lol..
|Posted by NickyVNza 6 months ago
Crazy animals... always freak me out! One of the scariest, creepiest movies, even now.
|Comment by gretaroxx is hidden because it exceeded your tolerance threshold. ( ? )
|[ Show/Hide Comment ]
|Posted by gretaroxx 8 months ago
this movie scared the shit out of me when i was a kid. read the book a couple of years ago and it terrified me too. rewatching this movie now, i didn't find it as scary but at least the ending is not as grim as the book's.
|Posted by Banchimae92 1 year ago
Another brilliant film by Stephen King. Loved the book and I do have to say this movie did it justice. No not everything was like the book but it was still really good. 10/10
|Posted by Goopus 1 year, 6 months ago
That little kid was annoying as hell.
|Posted by adranxl 2 years, 6 months ago
that dog though a good movie
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NASA's Terra Satellite Gets an Eyeful
NASA's Tropical Rainfall Measuring Mission (TRMM) satellite captured rainfall rates in Major Cyclone Narelle on Jan. 11 at 0654 UTC (1:54 a.m. EST). The heaviest rainfall was occurring at a rate of 2 inches (50 mm) per hour (in red) and stretched from north to west of the center of circulation.
Credit: NASA/SSAI Hal Pierce
When Terra passed over Narelle on Jan. 11 at 0245 UTC the Moderate Resolution Imaging Spectroradiometer (MODIS) instrument captured a visible image of the storm that clearly showed an eye had formed. Satellite imagery indicated that Narelle's eye was approximately 15 nautical miles (17.2 miles/27.8 km) wide. Satellite imagery also showed that Narelle had become more symmetrical and bands of thunderstorms had become more tightly wrapped into the center since Jan. 10.
Narelle Now a Major Cyclone
On Jan. 11 at 1500 UTC (10 a.m. EST), Tropical Cyclone Narelle's maximum sustained winds had increased to 115 knots (132.3 mph/213 kph), just as predicted by the Joint Typhoon Warning Center (JTWC). Narelle is now a major cyclone and a Category 4 hurricane on the Saffir-Simpson Scale. JTWC forecasters expect Narelle has now reached peak intensity and will begin to weaken hereafter as it moves parallel to the coast of Western Australia.
Narelle was located about 255 nautical miles (293.4 miles/472.3 km) north-northwest of Learmonth, Australia, near 18.3 south latitude and 112.6 east longitude. Narelle was moving to the southwest at 8 knots (9.2 mph/14.8 kph). Narelle is moving along the northwestern edge of a sub-tropical ridge (elongated area) of high pressure that is centered over Western Australia. The JTWC forecast noted that Narelle is expected to round the western edge of this ridge over the next three days before it recurves southeastward. By Jan. 14, the JTWC expects the system will become a cold core low pressure system as it moves over cooler waters and encounters increasing vertical wind shear.
NASA Satellite Sees Narelle's Heavy Rainfall
NASA's Tropical Rainfall Measuring Mission (TRMM) satellite captured rainfall rates in Major Cyclone Narelle on Jan. 11 at 0654 UTC (1:54 a.m. EST). The heaviest rainfall was occurring at a rate of 2 inches (50 mm) per hour and stretched from north to west of the center of circulation.
Warnings and Watches Posted
Until that time, however, warnings and watches are posted along the coastal areas of Western Australia. On Jan. 11, a Cyclone Warning was in effect for coastal areas from Mardie to Cape Cuvier. A Cyclone Watch is in effect for coastal areas from Cape Cuvier to Denham. A Blue Alert is effect for coastal and island communities from Mardie to Coral Bay including Onslow, Exmouth.
At 11 a.m. EST (1600 UTC) on Jan. 11, Onslow was reporting thunderstorms and sustained winds from the east-northeast. Onslow is a coastal town in the Pilbara region of Western Australia, located 1,386 kilometers (861 miles) north of Perth. Thunderstorms are expected to continue in the Pilbara region through Sunday, Jan. 13 as Narelle's center passes by while staying off shore. Onslow, Exmouth and other towns and cities in the Pilbara region are expected to clear by Monday, Jan. 14 as Narelle moves away.
For updates on warnings and watches, visit the Australian Bureau of Meteorology website: http://www.bom.gov.au/. The latest forecast from the JTWC (as of Jan. 11) keeps the center of Narelle over open water and never making landfall in any part of Western Australia. Narelle is expected to pass the southwestern tip of Australia sometime on Jan. 16 and move in a southeasterly direction over the Southern Indian Ocean where it will dissipate.
Rob Gutro | EurekAlert!
Further information:
Further reports about: > Australia > Cape Verde Islands > Cyclone > NASA > Narelle > Pilbara > Pilbara region > Saffir-Simpson > UTC > Warning > coastal areas > nautical miles > satellites > tropical diseases
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|Publication number
|Publication type
|Application number
|PCT number
|Publication date
|Aug 29, 2006
|Filing date
|Jul 6, 2002
|Priority date
|Jul 9, 2001
|Fee status
|Also published as
|Publication number
|Hartwig Preckel, Oliver Wendt, Axel Ehlert
|Original Assignee
|Evotec Oia Ag
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (11), Non-Patent Citations (7), Referenced by (1), Classifications (11), Legal Events (4)
|External Links: USPTO, USPTO Assignment, Espacenet
This is a National Phase Application in the United States of International Patent Application No. PCT/EP02/07554 filed Jul. 6, 2002, which claims priority on German Patent Application No. 101 32 530.4, filed Jul. 9, 2001. The entire disclosures of the above patent applications are hereby incorporated by reference.
The invention relates to a method for monitoring the operability of a liquid delivery device as well as to a liquid delivery device. Liquid delivery devices, for example, are pipetting or dispensing devices as well as pumps.
Dispensing and pipetting devices, for example, are used to fill sample carriers, such as, e.g., titer plates. Such titer plates comprise a plurality of wells, e.g., 1536 or 2080 wells, each well receiving a small quantity of sample liquid. Thereafter, the samples contained in the titer plates are analyzed in, e.g., automatic analysis processes such as the high throughput screening (HTS). A great number of samples is analyzed in a short time in high throughput screening installations in particular. Therefore, it is required to automatically fill the sample carriers with sample liquid.
Automatic dispensing or pipetting devices are employed to fill titer plates or other sample carriers. Such liquid delivery devices comprise a chamber for receiving liquid. Typically, the pressure in this chamber is increased to deliver liquid droplets. To this end, for example, a piezoelement is provided which acts upon the liquid provided in the chamber. Thus, liquid is delivered from a dispensing or pipetting tip by applying a voltage to the piezoelement. Sometimes, the delivered quantities for filling titer plates comprise only a few nanoliters, particularly less than 50 nl. For filling titer plates with a plurality of wells, several dispensing or pipetting devices are typically arranged next to each other and operated in parallel.
The micropumps, i.e., the combination of piezoelements and liquid chamber, are extremely susceptible to failure. Disturbances have an influence upon the liquid quantity delivered by the liquid delivery device. Particularly upon high throughput screening, even minor changes of the liquid quantity have a considerable influence upon the analysis results so that the analysis results are considerably falsified and thus become useless even with small liquid quantity deviations. Such disturbances, e.g., occur because of air bubbles in the chamber or capillaries connected to the chamber, from which the liquid is delivered or to which it is supplied. Further, depositions or efflorescences of or from the liquid may result in partial or complete cloggings. Disturbances may also be caused by liquid droplets at an outlet opening of the liquid delivery device since the flight direction of the drops is changed or the drops are not delivered at all. Disturbances may further occur as a result of changing physical properties of the liquid, such as, e.g., viscosity changes or changes of the composition of the liquid. Furthermore, disturbances may be caused by changing the ambience conditions, e.g., dipping the pipetting or dispensing tip into liquid.
It is the object of the invention to provide a method for monitoring the operability of a liquid delivery device by means of which the operability of the liquid delivery device is improved. Further, it is an object of the invention to provide a liquid delivery device with an improved operability.
This object is solved, according to the invention, with a method according to claim 1 and a device according to claim 19.
In a liquid delivery device with a liquid receiving portion and a transformer acting upon the liquid in the liquid receiving portion 12, e.g., an electromechanical transformer such as a piezoactuator, a response signal produced by a liquid-transformer system in operation is used, according to the invention, to perceive occurring disturbances such as air bubbles, cloggings and the like. The response signal may be, e.g., a current, voltage or charge signal. Either a signal directly emitted by the transformer or a signal obtained by a transform can be used as a response signal. The knowledge forming the basis of the invention consists in that a liquid-transformer system, i.e., a system substantially consisting of mechanical components of the transformer and of liquid onto which the transformer acts, comprises one or more characteristic "fluidic resonances". This means that at least a part of the mass of the liquid covibrates together with the mechanical components of the transformer and influences the vibrational properties in a characteristic manner. The response signal also includes, e.g., information on faults in fluidic partial systems of the liquid-transformer system. Particularly distinct changes occur at the resonance frequency (frequencies), wherein it is particularly possible to detect a frequency shift or attenuation. Characteristic changes of a response signal, however, can also be detected at other frequencies. In this case, e.g., the viscosity and the composition of the liquid onto which the transformer acts have to be considered as well.
Due to an inclusion of air, a clogging or changing physical properties of the liquid, e.g., the viscosity, the liquid-transformer system experiences a change of the vibrating mass. In other words, a response signal changes when the liquid-transformer system is excited by an excitation signal and a disturbance and/or change occurs. The response signal also changes when, e.g., the dispensing or pipetting tip, i.e., a delivering tip of the liquid delivery device, is dipped into liquid or a drop clings to the tip. Thereby, a part of the vibrations is transferred to the liquid into which the tip is dipped or the clinging drop increases the vibrating mass.
According to the method according to the invention, the transformer of the liquid-transformer system is excited by an excitation signal. This excitation is effected, for example, at regular time intervals during operation. At different times, different excitation signals can be used. Preferably, the excitation signal corresponds to a frequency of resonance. An excitation signal close to a frequency of resonance is also preferred. Preferably, the frequency difference between the frequency of resonance and the excitation signal is twice the half-width of the resonance at maximum. In the next step, the response signal of the liquid-transformer system caused by the excitation signal is acquired. Subsequently, the response signal is compared with a reference value. The reference value is, e.g., a preset value or a value stored in a control unit. The comparison between one or more reference values and a response signal can be made directly by means of an appropriate electronic circuit. It is also possible to compare and evaluate the signals in digitized form, respectively, with the use of software, if necessary. Because of a comparison of the response signal with the reference value, it can be decided whether a malfunction of the liquid delivery device is given. If this is true, a correction step is performed.
Preferably, the reference value is a response signal of the liquid-transformer system in which there are no disturbances such as cloggings and the like. This reference value, for example, may be stored in a memory means. Such a reference value is preferably determined by measuring the response signal of an operative liquid-transformer system at a frequency of resonance. This measurement can be performed once and then, the reference value is stored in the memory means. For checking purposes, a corresponding measurement can be repeated at regular intervals. It is also possible to determine a reference value before each measurement. In this embodiment of the method, the correction step is preferably performed when the response signal exceeds or falls short of a limit value.
In another preferred embodiment of the method, a response signal of a disturbed liquid-transformer system, i.e., a liquid-transformer system with a certain type of clogging, for example, is preset as a reference value. This reference value, in turn, may be stored. The reference value can be determined, in turn, by measuring a response signal in a malfunctioning liquid-transformer system and storing it in a control means. In this preferred embodiment of the method, the correction step is preferably performed when the response signal lies within a preset deviation from the reference value. This means that the response signal substantially corresponds to the reference value here so that it can simultaneously be detected which type of disturbance has occurred, e.g., whether there is a partial or a complete clogging. Preferably, several reference values are stored in dependence on occurring disturbance types. Different reference values are stored, for example, for a complete clogging, a partial clogging or a drop clinging to the tip of a pipetting or dispensing means. Thus, it is possible to simultaneously detect the type of disturbance on the basis of the response signal.
The reference value, which may be the reference value of an operative or a malfunctioning liquid-transformer system of a certain type of disturbance, may also be detected by means of substitute models of the liquid-transfer device. It is particularly possible to detect reference values by means of computer simulations.
Preferably, a correction step will only be performed when the limit value has been exceeded/fallen short of or a response signal within a preset deviation from the reference value has occurred repeatedly, e.g., within a preset period of time, or in immediate succession. Thus, a correction step is performed in dependence on statistics.
The liquid delivery pump may also be a pump such as a HPLC pump, for example. In this case, a response signal can be measured directly at the pump or by a succeeding liquid-transformer system. The reference value itself may be variable as to time (f(t)), the variation being calculated or generated as a function of a further measured signal, such as, e.g., as a function of the relation of acetonitrile/water in case of a HPLC pump. By means of the method according to the invention, it is thus possible to determine the composition of the HPLC liquids, e.g., in connection with a preset gradient.
It is also possible, for example, to detect the state of a valve by means of the method according to the invention by the use of an additional liquid-transformer system. As soon as the valve has been opened, there is liquid in a portion located behind the valve in flow direction. Thereby, the response signal changes. Thus, the operability of a valve can be checked by means of the method according to the invention. This is particularly advantageous with microsystem chips.
The reference value, e.g., is a value (e.g., input impedance in case of a frequency), a combination of values (e.g., input impedance in case of several frequencies), a certain limited range of values (partial spectrum (e.g., input impedance between 1000 and 3000 Hz)), an entire spectrum and/or a mathematical function. The reference value can be regarded as a value, i.e., as a single curve, for example, or as a tolerance range, i.e., between two curves, for example. Preferably, the response signal is determined in a first step at a single frequency for determining the error occurred as exactly as possible. This frequency is included in the spectrum of the reference value. If the response signal obtained by this frequency does not permit a clear statement as to the error, the response signal is preferably determined with a combination of frequencies, ranges of different frequencies (partial spectra) or in correspondence with the reference value over the entire spectrum. Thereby, it is possible to detect the exact error in question—if necessary, in several steps.
The correction step may consist in performing a cleaning step or dabbing a dispensing or pipetting tip. Another example for a correction step is to stop the liquid delivery with or without outputting a corresponding signal to the user. Then, in dependence on the detected error, for example, the user may execute a cleaning, a new adjustment or the like at the liquid delivery device. Further, the detected error value may also be stored. Such a storing may be used for statistical evaluations in order to check whether the detected type of error really corresponds to the actual type of error, etc. It is also possible, for example, to neither change the delivered quantity nor perform a cleaning or the like in a correction step but rather merely store the detected error and continue the liquid delivery procedure without any changes. The storing may be performed, for example, with respect to a particular well so that, in a future examination of this well, it is known that errors have occurred when delivering liquid into this well and thus, the measured results might be falsified. Depending on the type of the error occurred, it may be relevant for all the succeeding wells or also for the specific well only.
The method may be carried out, e.g., at regular intervals during a procedure of filling titer plates or other sample carriers. It is further possible to continuously carry out the method according to the invention during the entire filling procedure. This is a particularly preferred embodiment of the method. Preferably, the state of the liquid-transformer system is measured by the signal by which the liquid delivery device is simultaneously operated. To this end, a signal is chosen which is suitable for exciting the liquid-transformer system and includes the frequencies at which the response signal is to be measured. In the simplest case, a sinusoidal signal can be used. To guarantee a corresponding actuation of the transformer, the excitation signal comprises a sufficient amplitude. Thus, it is possible to operate the liquid delivery device as well as to simultaneously carry out a function monitoring with one and the same signal.
The method according to the invention has the advantage that no additional sensor for monitoring the operability of the liquid delivery device is required. The monitoring is rather performed directly via a preferably reversible electromechanical transformer such as a piezoactuator of a micropump, which simultaneously operates the liquid delivery device and performs the operability monitoring as well. Further, a plurality of different errors can be detected by the method according to the invention. Apart from the fact that air or gas bubbles can be detected in the liquid, cloggings, efflorescences and depositions are detectible as well. As described above, it is also possible to detect a dipping of the liquid delivery tip in a liquid. By means of the method according to the invention, it is particularly possible to detect physical changes of the liquid. A change of viscosity caused by temperature variation, for example, is detected by means of the method according to the invention. By means of the method according to the invention, it is also possible to detect that a liquid drop clings to the liquid delivery tip, since the mass of this liquid drop is a part of the mass of the liquid-transformer system and thus, a response signal is produced that differs from the reference value.
The liquid acted upon by the transformer is preferably disposed in a chamber, particularly a chamber of a micropump. Typically, the chamber of a micropump comprises an inlet opening of small diameter for supplying liquid into the chamber. Further, the chamber of a micropump comprises an outlet opening that also has a small diameter. By generating pressure in the chamber by means of a piezoactuator, liquid is ejected from the outlet opening. By such pumps, it is possible to eject minimum quantities of liquid in the range of a few nanoliters or less. By micropumps, single drops or a larger quantity of liquid can be ejected.
In another preferred embodiment of the invention, the generation of the excitation signals as well as the reception of the response signal is effected by means of the transformer. This can be performed by the fact that the transformer generates a pulse as an excitation signal, is switched to reception mode and is thus able to receive the response signal of the system. It is then required, however, that the excitation pulses are very short since the response signal comes very fast because of the small size of the system.
In a particularly preferred embodiment, the delivery of the excitation signal and the reception of the response signal is effected simultaneously or may overlap in time at least partially. With an electric or electromechanical transformer such as a piezoactuator, this may be effected by applying a voltage to the transformer. Then, the response signal of the liquid-transformer system is the current flowing in the transformer, for example. Thus, the response signal is a measure for the "resistance" the transformer meets upon moving the liquid. From this response signal, i.e., the "transformer resistance", information on a disturbance such as an air bubble, a clogging of the nozzle or a covibration of a drop hanging in a nozzle etc. can be obtained. Preferably, the response signal is determined by means of the impedance, the capacitance and/or the admittance of the liquid-transformer system. Preferably, the reference value is determined by means of the impedance, the capacitance and/or the admittance of the liquid-transformer system as well. By means of the electric impedance, e.g., it is easily possible to detect changes in the phase shift between current and voltage, occurring at malfunctions. The input impedance, the input admittance or the input capacitance can be used for measuring.
After having detected a malfunction by comparing the reference value with the response signal, a cleaning cycle, for example, can be carried out as a correction step. A cleaning cycle, for example, is the continuous delivery of a large liquid quantity. This effects the flushing of air bubbles, depositions and the like from the chamber. If, for example, a change of the viscosity of the liquid is detected by the method according to the invention, a change of the excitation signal of the electromechanical transformer can be effected-as a correction step as well so that an adaptation of the delivered liquid quantity to the changed viscosity of the liquid is effected. This results in that a constant drop volume can also be produced with changing viscosities of the liquid. Corresponding excitation signals in dependence on the viscosity are preferably deposited in the memory means.
The different disturbances (air bubbles, depositions, dipping into a liquid) cause a different response signal. Since the response signals can be differentiated, it is possible to detect the type of error on the basis of the response signal. It is possible to directly detect the type of error by a suitable control means in which the different values of the response signals with respect to an error type are stored. This results in that by means of the control means, the reactions can be different in dependence on the type of error. If an air bubble was detected in the chamber, the chamber could be flushed, for example. If, for example, a drop clinging to the liquid delivery tip was detected, it would be possible to simply and effectively rectify the error by dabbing the liquid delivery device on an absorbent cloth or the like.
Further, the method according to the invention is also suitable, e.g., for the monitoring of pumps, particularly HPLC pumps. Here, it is possible not only to monitor the operability of the pump but also to control the pump itself by means of the method according to the invention. When the method according to the invention is employed in connection with pumps, particularly HPLC pumps, a monitoring of the gradient in the HPLC pump is possible. Here, a change of the composition of the liquid because of contamination or the like is detected as a malfunction. As a correction step, the respective pumps of the liquids can here be controlled differently to readjust the gradient.
In a preferred embodiment of the method according to the invention, it is possible to not only provide the excitation signal as a single excitation frequency but as a signal comprising several excitation frequencies, e.g., as a square wave signal. Thereby, it is possible to accommodate several points, partial spectra or an entire spectrum of the response signal. Then, for example, different combinations of frequencies or signals can also be significant for different types of errors.
For exciting the liquid-transformer system for receiving the response signal, it is further possible not to use the same means as that producing the signal acting upon the transformer but to provide different means. The excitation of the liquid-transformer signal, for example, may be effected electrically or magnetically via a transformer and the acquisition of the response signal can be effected mechanically or optically. Furthermore, it is possible that the transformer for the liquid delivery and the function monitoring is not identical.
Further, the invention relates to a liquid delivery device being particularly suitable for delivering minimum quantities. The liquid delivery device comprises a liquid receiving portion, such as, for example, the chamber of a micropump. Further, the liquid delivery device comprises a transformer acting upon the liquid provided in the liquid receiving portion. The transformer is, for example, a reversible transformer, preferably an electromechanical transformer, such as a piezoactuator. In further preferred embodiments, it is, for example, a magnetorestrictive transformer. Further, the liquid delivery device comprises a control means connected with the transformer. The control means serves to excite the transformer with an excitation signal. Further, the control means preferably also serves to acquire a response signal of the liquid-transformer system. It is a response signal to the excitation signal. Further, the control means serves to compare a reference value with the response signal. As described above, the reference value may be, for example, a value or a combination of values etc. of an operative or a malfunctioning system. Preferably, it is stored in the control means.
The liquid-transformer system comprises the transformer and the liquid receiving portion. Substantial for the invention is that the liquid receiving portion is also considered to be a portion having influence upon the response signal. Further, all the other covibrating portions of the liquid-transformer system have influence upon the response signal.
In a particularly preferred embodiment, the transformer simultaneously acts as an actuator and as a sensor. As described above with respect to the method according to the invention, the generation of the excitation signal as well as the reception of the response signal may be effected with a time offset or preferably simultaneously or in an overlapping manner. Here, it is particularly preferred to determine the input impedance, the input capacitance and/or the input admittance of the transformer. If necessary, the response signal is carried out by means of a software or the comparison between the response signal and the reference signal is made by means of a software to be able to detect even extremely minor changes. With droplets clinging to the nozzle or with partial cloggings, for example, the input impedance changes are only extremely small. In this case, it is advantageous to favorably select the frequency at which the comparison of the response signal with the reference value is made in dependence on the liquid-transformer system. Particularly the measuring parameter has to be chosen advantageously. The phase values have proven to be advantageous measuring parameters.
The liquid delivery device according to the invention is particularly suitable for carrying out the above method. The respective components of the liquid delivery device according to the invention and particularly the control means are configured such that they are suitable for carrying out the above method and particularly the preferred embodiments.
Hereinafter, the invention is described in detail with respect to preferred embodiments with reference to the accompanying drawings.
In the Figures:
In the illustrated embodiment, a dispensing device 10 is illustrated as a liquid delivery device. It comprises a chamber 12 filled with sample liquid. Via a channel 14, the chamber is connected with a reservoir. At a dispensing tip 16, an outlet opening 18 is connected with the chamber 12 via a capillary 20.
A rear wall 22 of the chamber 12 has a flexible configuration. A piezoactuator 24 is provided adjacent to the rear wall 22. Via a line 26, the piezoactuator is connected with a control means 28. The piezoactuator 24 can be activated by the control means 28. By activating the piezoactuator, pressure is exerted on the flexible rear wall 22 of the chamber 12. Because of the pressure increase in the chamber 12, droplets 30 are ejected from the outlet opening.
The control means 28 preferably is a computer (
By means of a measuring resistor 42, a response signal 44 is supplied to the control means 28 via the A-D converter 34. The response signal is the response signal of the liquid-transformer system, i.e., the response signal particularly caused by the transformer 24 as well as by the liquid in the chamber 12 and all the liquid communicating therewith (e.g., capillaries 20, drops at the nozzle etc.) The other mechanical parts of the liquid-transformer system, such as, for example, the diaphragm and the capillary 20, have an influence on the response signal. In the operational state, i.e., during the monitoring of the operability, the response signal 44 is the response signal. Before, the reference value is produced with the same circuit illustrated in
The diagram illustrated in
In order to detect a disturbance—an air bubble in the present example—a liquid-transformer system is excited by a signal including the frequency to be analyzed. In the present example, the signal may include a frequency of about 3000 Hz corresponding to the line 52. Subsequently, the complex capacitance from the time signal is analyzed by Fourier transform. At least, this analysis must be effected at the frequency of interest 52. At the resonance frequency (line 52), the curve 46, i.e., the curve of an operative non-disturbed liquid-transformer system is below a limit value φs illustrated by the line 54. The phase angles of the two curves 48,50 representing the response signals in case of disturbing air bubbles lie above the limit value φs. As is clearly apparent from the lower diagram of
Two diagrams corresponding to those of
As can be seen from the diagrams in
|Cited Patent
|Filing date
|Publication date
|Mar 31, 1994
|Nov 17, 1998
|The Technology Partnership Plc
|Apparatus for generating droplets of fluid
|Apr 30, 1999
|Aug 1, 2000
|Packard Instruments Company
|Method for verifying proper operation of a liquid sample dispenser
|Apr 30, 1999
|Sep 5, 2000
|Packard Instrument Company
|Method for dispensing and determining a microvolume of sample liquid
|Dec 3, 1998
|Dec 12, 2000
|Bayer Corporation
|Method and apparatus for aspirating and dispensing sample fluids
|Sep 19, 1990
|Mar 26, 1992
|Werner Kellermann
|Control for dosing system - monitors pump pulses to compute dosing rate and detects pressure fluctuations
|Jul 16, 1993
|Jan 26, 1994
|Pasteur Sanofi Diagnostics
|Method of and device for fluid surface detection using an ultrasonic transducer
|Title not available
|Title not available
|Title not available
|Apr 8, 1998
|Oct 15, 1998
|Packard Instrument Company, Inc.
|Microvolume liquid handling system
|Dec 10, 1999
|Jun 15, 2000
|Aurora Biosciences Corporation
|Fluid dispenser and dispensing methods
|English Language Translation of International Preliminary Examination Report for PCT/EP2002/007554, completed Oct. 28, 2003.
|German Search Report, dated Apr. 12, 2002, 4 pages.
|International Preliminary Examination Report for International Application in German.
|International Search Report for International Application completed Feb. 5, 2003 and mailed Feb. 13, 2003, completed by C. Hanisch.
|Koisumi Yukihisa, Bubble Detecting Device for Ink Flow Path in Ink Jet Printer, Patent Abstracts of Japan, Publication No. 01150549, Published Jun. 13, 1989.
|PTO 06-311, English language translation of Japanese Patent Application HEI 1 [1989]-150549 published Jun. 13, 1989.
|Tomita Mitsuo, Dispensing Apparatus, Patent Abstracts of Japan, Publication No. 11125638, Published May 11, 1999.
|Citing Patent
|Filing date
|Publication date
|Oct 5, 2011
|Oct 28, 2014
|Baxter International Inc.
|Non-invasive radio frequency liquid level and volume detection system using phase shift
|U.S. Classification
|International Classification
|Cooperative Classification
|European Classification
|Jul 6, 2004
Owner name: EVOTEC OAI AG, GERMANY
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:PRECKEL, HARTWIG;WENDT, OLIVER;EHLERT, AXEL;REEL/FRAME:015673/0143
Effective date: 20040624
|Jan 9, 2007
|Certificate of correction
|Feb 18, 2010
|Fee payment
Year of fee payment: 4
|Feb 24, 2014
|Fee payment
Year of fee payment: 8


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10 Most Popular Photoshop Techniques Posted On ePz - We list the Photoshop techniques our members have checked out the most over the last year.
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By: Going Like Sixty - Published: Mar 28, 2008 • References: crystalbridges.org


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Google is testing a brand-new layout for local listings in their regular Google search results, this time with the company's logo displaying on the left-hand side where you would normally see a map icon with location details.
It also appears for businesses that do not have a logo to display, it will show a thumbnail of the location on a map, along with a red Google maps pin.
This test was seen on desktop Chrome.
This style of local pack also brings it much closer to a search results style that Google was testing on mobile last year.
Google does not seem to be pulling the logos from images in the Google My Business listings. Instead they simply pulling the logo straight from the website, and they do seem to be making an attempt to somewhat thumbnail it to show the entire logo.
When expanded, it shows additional listings, with one default Google Maps thumbnail while the remaining listings are all "action shots" similar to what we have seen on hotel and restuarant local packs in the search results.
This local listing is definitely more eye-catching than your standard pack listings. It shows up as a three pack, but it is also expandable to show more listings.
We have seen Google play around with thumbnail images showing in local parks, but it is primarily only been in the hotel and restaurant spaces, where it will show an image of the hotel or one of the restaurant dishes.
Hat tip to Justin Aldridge who spotted it and send me multiple screenshots. He also posted the original image to Twitter.
Jennifer Slegg
Latest posts by Jennifer Slegg (see all)
- Google Adds Thumbnails to Food Related Wikipedia Results - May 27, 2016
- Google Lets Searchers Choose Language When Query In Different Language - May 27, 2016
- Google Showing Third Party Reviews in Local Map Results - May 26, 2016
- New AMP Features Including Social Sharing, Sidebars & Collapsing Sections - May 25, 2016
- Why Google Removed the Right Sidebar AdWords Ads - May 24, 2016


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Fordham's Community Service Program and Campus Ministry are once again sponsoring the annual Food and Coat drives to benefit the local community partners in the Bronx and Manhattan. Community-based organizations such as Part of the Solution (POTS), Concourse House, National Student Partnerships (NSP) and Cathedral Community Cares of St. John the Divine will benefit greatly from your generous support.
Thanksgiving Food Drive - November 10 through 21
Local food pantries are struggling to meet the needs of their clients, particularly during the holiday season. If you would prefer to make a monetary donation, please make checks out to "Campus Ministry."
Non-perishable food items and checks may be brought to:
ROSE HILL: McGinley Center 101 or 102
LINCOLN CENTER: Lowenstein 217
Winter Clothing Drive - December 1 through 19
As the weather gets colder, we will begin to collect warm winter clothing in good condition to be distributed through our community partners. If you would prefer to make a monetary donation, please make checks out to "Campus Ministry."
Coats, sweatshirts, scarves, gloves, sweaters, and socks, as well as checks may be brought to:
ROSE HILL: McGinley Center 102
LINCOLN CENTER: Lowenstein Plaza (bins at the top of the escalator)
For more information, please contact
Rose Hill: 718-817-4501 or firstname.lastname@example.com
Lincoln Center: 212-636-6267 or email@example.com
Rose Hill: 718-817-4510 or firstname.lastname@example.com
Lincoln Center: 212-636-7464 or email@example.com
We thank you on behalf of our community partners and neighbors for your generosity.
Baylor University Board of Regents announces leadership changes and extensive corrective actions following findings of external investigation - *Baylor University || Media Communications || News* Kenneth Starr was the inquisitor of Bill Clinton. He exposed the then President's sexual affair with a...
17 hours ago


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Alternative Investments - Real Estate Investments
What is Real Estate?
Forms of Real Estate Investments
- Free and Clear Equity - A free and clear equity investment confers full ownership for an indefinite period of time. The investor gets all ownership rights. It is an outright purchase of the asset with no encumbrances.
- Leverage Equity - Leverage equity has same ownership rights as free and clear equity but is subject to debt (promissory note) or a pledge (mortgage) to hand over those rights if payments and terms of the debt are not met.
- Mortgages- Mortgages are debt investments in which the mortgage holder receives a stream of payments like a bondholder (principal and interest). Mortgage holders are a type of real estate investor because they are entitled to take possession of the real estate asset if the mortgagee defaults. Mortgages can include a clause for early prepayment, which impacts the investor's payment flows. Investors diversify their real estate portfolios by purchasing mortgages that vary in terms of region, duration of the mortgage and type of property (commercial, residential, etc.)
- Aggregation Vehicles - Aggregation vehicles pool investors' funds together, giving them broader and deeper access to the real estate market.
These include:
- Real estate limited partnerships allow groups of investors to participate in the real estate market with liability limited to the amount of their original investment. Management of the property is left to experts in the field. Like other limited partnerships, a real estate limited partnership is owned by one or more general partners who handle the organization's operations, and by one or more limited partners who participate financially but have no say in the management and operation of the partnership. For limited partners, the risk of loss is limited to their investment. Often, these partnerships are put together to build shopping centers or low-income housing. The appeal to investors is the special tax deductions they hold for developers and that are passed through to the investors. Unfortunately, most individual investors aren't in high enough income brackets to take full advantage of the deductions.
Limited partnerships can be purchased through stockbrokers. Because they are laden with high sales commissions and management fees, investment income - and therefore total return - is reduced accordingly. Limited partnerships are not liquid - selling a partnership interest in a timely fashion is often difficult. A five- to 20-year investment horizon is not uncommon. In many cases, the only option for cashing-out and liquidating the partnership interest is liquidation of the partnership itself. In the past, real estate limited partnerships lost substantial amounts of money for a variety of reasons, including the impact of changes in federal income tax legislation.
- Commingled funds are pools of money made up of contributions from a number of different pension plans or other funds. The money is managed by a professional money manager, be it a bank, insurance company, or independent investment counselor. The fund contributes money to the pool, and it is mingled together - or "commingled" - with the assets of the manager's other clients. When these pools consist entirely of pension money, the commingled funds are tax exempt. Investors take profits on a pro rata basis according to the amount they invested in the fund. They can be open or closed end funds.
- REITs (Real Estate Investment Trusts) are a well-known type of closed end fund that buys, develops, manages and sells real estate assets. REITs allow participants to invest in a professionally-managed portfolio of real estate properties. They distribute or "pass-through" the majority of their cash flows to investors. Most REIT revenues come principally from the rental income their properties generate. In fact, most are actually restricted to generating only property rental income. Since REITs are traded on the major exchanges, they are more liquid than limited partnerships and even compared to traditional private real estate ownership.
Equity REITS invest in and own properties (and are therefore responsible for the equity or value of their real estate assets). Mortgage REITs deal in investment and ownership of property mortgages. These REITs loan money for mortgages to owners of real estate, or purchase existing mortgages (or mortgage-backed securities). Most of their revenue comes from interest earned on the mortgage loans. Hybrid REITs combine the investment strategies of equity REITs and mortgage REITs by investing in both properties and mortgages.
Related Articles
Mutual Funds & ETFs
At Look at REITS vs. Real Estate Mutual Funds (ESRT, TRREX)REITs and real estate mutual funds have their differences, but they both offer liquidity and easy access to diversified real estate assets.
How to Invest in Real Estate Without Buying PropertyInvesting in real estate can require more capital than most investors have available, but there are options to invest in real estate for less.
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Simple Ways to Invest in Real EstateOwning property isn't always easy, but there are plenty of perks. Here are some ways to invest in real estate.
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5 Types Of REITs And How To Invest In ThemReal estate investment trusts are a sound addition to a diversified portfolio. Learn what you need to know to invest.
Credit & Loans
4 Key Factors That Drive The Real Estate MarketWhether you are investing directly or indirectly in property, you need to know the factors that affect its value.
Investing Basics
5 Simple Ways To Invest In Real EstateThere are many ways to invest in real estate. Here are five of the most popular.
What Is a REIT and Does It Belong in My Portfolio?Real estate investment trusts offer a unique way for investors to own a real estate portfolio without the risks of owning single properties.
Home & Auto
Exploring Real Estate InvestmentsDiscover how owning properties can give you a roof over your head or a check in your pocket.
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How You Make Money In Real EstateIf you're interested in the real estate game, make sure you know what factors will affect whether you make money or not.
Stock Analysis
Gains In International Real EstateAfter an impressive housing market run in 2010, many have missed out on U.S. real estate bargains. But steady gains in international real estate have investors looking beyond the borders.
Real Estate Investment Trust - ...A REIT is a type of security that invests in real estate through ...
Blanket MortgageA mortgage which covers two or more pieces of real estate. The ...
Funds Available For Distribution ...An informal measure of the amount of capital that is on hand ...
MortgageA debt instrument, secured by the collateral of specified real ...
Alligator PropertyIn real estate, when the cost of mortgage payments, property ...
Real Estate Short SaleAny sale of real estate that generates proceeds that are less ...
What is the difference between a REIT and a real estate fund?... Read Answer >>
What is the difference between an Equity REIT and a Mortgage REIT?Find out more about real estate investment trusts and the main differences between equity and mortgage real estate investment ... Read Answer >>
How have low interest rates affected the real estate sector?Learn how low interest rates stimulate the real estate sector by making it more affordable to borrow money to invest in real ... Read Answer >>
How do real estate hedge funds work?Understand what a hedge fund is and how it differs from a mutual fund. Learn about the ways in which a hedge fund becomes ... Read Answer >>
What does asset management mean in regards to real estate?Find out what role asset managers play in the real estate markets, how real estate portfolios are selected and why entrepreneurial ... Read Answer >>
Why can real estate be a good addition to a traditional stock and bond portfolio?Discover why real estate can be a good addition to a traditional stock and bond portfolio. Real estate is affected by economic ... Read Answer >>


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Here is a 5 yr old stallion that loves to work cattle and has natural stop and quickness . If you've ever wanted a horse that will watch and hunt a cow…$15,000
http://www.youtube.com/watch?v=aA0B0dIkccU I have decided to sell one of my retired bullfighting stallions, just to let you know this is done in California…$20,000
Completey bombproof stallion sired by an imported 16.3 black PRE stallion. His gaits and disposition are outstanding in the arena. Strikingly beautiful…$26,000
Woodie is: 94.73% foundation bred (FQHA) 5-panel negative Homozygous black (EE). Heterozygous agouti (Aa) AQHA Parentage verified/DNA tested APHA…$6,500
STALLION PROSPECT! SIRE: FRENCH STREAKTOVEGAS by A STREAK OF FLING www.frenchstreaktovegas.com/stallion.html DAM: NOKILLER by DASH FOR PERKS o/o a MASTER…$15,000
Here is a son of Peptoboonsmal that I am offering his 2016 babies for sale. The picture was took when he was two. He is a great stallion that has a super…No Price Listed
2016 STUD FEE $400 - FARM FEE $200 - MARE CARE $9/$11 CONTACT US for special stud fee consideration on your mare. If you want a quiet, good looking…$400
Has been hauled. Ready to go in whatever direction you want. He has been brought through poles and barrels for exercise. He has been sorting and would…$3,500
Powderhorn, CO


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Departament d'Enginyeria mecànica
Altres [3]
Articles de revista [146]
Llibres [11]
Presentacions [2]
Reports de recerca [13]
Working papers [4]
Recent Submissions
Theoretical and experimental investigation on inclined ultrasonic elliptical vibration cutting of alumina ceramics (2016-05-05)
Restricted access - publisher's policyAlumina (Al2O3) is an extremely hard and brittle ceramic that is usually used as an abrasive or a cutting tool insert in manufacturing. However, its growing applications in industrial products make it necessary to conduct ...
A hybrid mixed double-sided incremental forming method for forming Ti6Al4V alloy (2016-05-12)
Restricted access - publisher's policyIncremental forming can be an alternative manufacturing means in producing biomedical parts characterized by the need of patient-specific geometry. A novel hybrid dieless sheet metal forming process, electrically-assisted ...
A dynamic analysis of an integrated lower limb-orthosis model for interface contact pressures estimation (2014)
Conference report
Restricted access - publisher's policy
Análisis del efecto del apriete y la rigidez de contacto en la precisión de un mecanismo de levas conjugadas (2012)
Conference report
Restricted access - publisher's policyLos mecanismos de levas conjugadas requieren de un ajuste con apriete para compensar las tolerancias de fabricación y montaje y al mismo tiempo evitar la separación de las superficies de las levas y los ...
Evaluation of the influence of a planned interference fit on the expected fatigue life of a conjugate cam mechanism- A case study (2013-08-01)
Restricted access - publisher's policyDue to dynamic effects, clearances, manufacturing and assembly errors in form-closed cam mechanisms, the follower jump can also occur. For conjugate cam mechanisms a technique to avoid the follower jump without the use of ...
Numerical models of railway tracks for obtaining frequency response Comparison with analytical results and experimental measurements (2016-03)
Restricted access - publisher's policyMany authors have focused their research on the vibrations caused by railway traffic, and have developed diverse models of railway tracks: from half-track analytical models up to complex numerical models. This paper presents ...
Microfluidic point-of-care blood panel based on a novel technique: Reversible electroosmotic flow (2015-09-11)
Open AccessA wide range of diseases and conditions are monitored or diagnosed from blood plasma, but the ability to analyze a whole blood sample with the requirements for a point-of-care device, such as robustness, user-friendliness, ...
Physics-based motion planning: evaluation criteria and benchmarking (Springer, 2015)
Conference report
Restricted access - publisher's policyMotion planning has evolved from coping with simply geometric problems to physics-based ones that incorporate the kinodynamic and the physical constraints imposed by the robot and the physical world. Therefore, the criteria ...
Reasoning-based evaluation of manipulation actions for efficient task planning (Springer, 2015)
Conference lecture
Restricted access - publisher's policyTo cope with the growing complexity of manipulation tasks, the way to combine and access information from high- and low-planning levels has recently emerged as an interesting challenge in robotics. To tackle this, the ...
Vibration measurements of a wire scanner - experimental setup and models (2016-03-01)
Restricted access - publisher's policyIn the next years the luminosity of the LHC will be significantly increased. This will require a much higher accuracy of beam profile measurement than actually achievable by the current wire scanner. The new performance ...


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Porn Star Heather Hunter Tears Up as She Recalls Starring in 2Pac's X-Rated "How Do You Want It" Video
Porn star Heather Hunter takes us back to 1994 on the set of 2Pac's adult video for "How Do You Want It."
Porn star Heather Hunter takes us back to 1994 on the set of 2Pac's adult video for "How Do You Want It."
MC Eiht talks about 2Pacs gang affiliation and whether or not it was a good look for him.
The first Hip-Hop group to land on the radio, the Sugarhill Gang is still around and still getting their props. Their groundbreaking hit "Rappers Delight" is getting some serious recognition from some people in high places.
It was on this day Sept. 13, 1996 that the music world lost one of the greatest rappers to ever live, Tupac Shakur. If he was still with us, Pac would be 40 years old, but sadly, he was only 25 years old when he was gunned down shortly after a Mike Tyson fight in Vegas. Still to this day, there are no leads and no arrests in his unsolved murder.
Those who've been arguing as to whether or not Tupac is alive will have one more thing argue about soon. Word has it, a new Tupac album is in the works and will be released September 13th. The first single is entitled "Thugz Get Lonely Too" featuring vocals from Al Green.


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Season 4, Episode 19 We're Off to See the Wizard
First Aired: April 25, 2002
An enigmatic wizard seeks the Charmed Ones' help in stopping a coronation in the underworld that would provide the new Source with his full powers. Meanwhile, Phoebe has big news for her sisters and her husband. Phoebe: Alyssa Milano. Piper: Holly Marie Combs. Paige: Rose McGowan.
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