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WOODWARD KENNELS - North Dakota German Shorthaired Pointer Breeders
Want to list your puppies for sale? Post a classified today!
About WOODWARD KENNELS
At Woodward Kennels, our goal is to breed very conformationally correct GSP's that are also very birdy, and with loving personalities. Pups have TONS of natural instinct. All puppies are vet checked, current on shots by a licensed veterinarian, tails, dewclaws & worming done. All of our dogs have had their hips certified by OFA'd and we take great pride in producing healthy happy puppies. All of our puppies are born in the house and raised in the house to get them used to a home's general sights, sounds and chaos plus of course, lots of hugs and kisses. They are handled from the time they are born until they go to their new owners at 8 weeks. They are exposed to lots of different sounds, textures, and environments. These are definitely family dogs for the home that "turn on" in the field for an incredible hunting partner; however, we encourage some form of puppy social /obedience class for new puppies and their families. We don't raise "kennel" dogs. We have 10 GSP's and they all live in the house with us. They are like our children. Some people have lots of kids, we have 4-legged kids to bring enjoyment to our lives :) Our dogs participate in AKC, NSTRA field trials and hunt tests. Our dogs are great natural bird hunters with outstanding nose and strong desire. They exhibit sweet temperament and expression and are excellent with other animals. They are wonderful hunting partners and exceptional family companions. We expect great hunting dogs from all of the litters that we produce.
Hunting Dog Breeds Raised
German Shorthaired Pointer
Additional Services
Training, Stud Services, Boarding
Breeder Contact Info
EPPING, North Dakota 58843
Breeding quality gun dogs for over 5 years.
701-570-6389Send Email to WOODWARD KENNELSClick here to visit WOODWARD KENNELS website
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Woman killed in explosion outside cracker unit
Last Updated: Friday, March 23, 2012 - 17:22
Kozhikode: A 34-year-old woman, working in a
cracker manufacturing unit at Kakkoor, was killed when
some explosives she was carrying in a bag exploded on Friday.
The woman was carrying the explosives in a plastic bag
when it fell on ground and exploded outside the unit, killing
her on the spot and injuring another.
Two other women, who were working inside the unit, escaped
unhurt, police added.
First Published: Friday, March 23, 2012 - 17:22
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|By Andreas Grabner
Article Rating:
|October 6, 2014 09:15 AM EDT
Are you developing or hosting PHP applications? Are you doing performance sanity checks along your delivery pipeline? No? Not Yet? Then start with a quick check. It only takes 15 minutes and it really pays off. As a developer you can improve your code, and as somebody responsible for your build pipeline you can automate these checks and enforce additional quality gates. And as a PHP Hosting company / group you will be able optimize your deployment and run more of these apps and sustain more load on the same infrastructure.
Just like Java, .NET, and Ruby type applications, the top performance bottlenecks are fairly easy to spot and fixing them improves end user performance and saves compute power for your servers.
Here is what we discovered when analyzing our own Moodle-based educational platform using the 15 Day Free Trial of dynaTrace:
- High PHP Compilation Time: Our App spends up to 66% of the time in compilation
- Bad database access patterns: Some of our web requests execute up to 592 SQL requests
- Inefficient PHP coding: Rendering HTML lists in result pages takes 5+ seconds
If you are interested in learning more about PHP Performance, be sure to check these posts out: Basic PHP Performance Tips (Google Dev) and 5 Things to Improve PHP Performance (DZone).
#1: PHP Compilation Time
In a standard PHP installation every web request processed by the PHP engine will be compiled. The compiled code will not be cached which means PHP needs to re-compile the same code when the next request comes in. In our system we saw compilation time spikes of up to 66% of the total execution time:
Many of our requests spend a lot of time in compiling complex PHP files. Optimizing these files will improve overall response time
It also pays off to analyze PHP Compilation Time long term. In our case we noticed that a new deployment let the Compilation Time Contribution jump to twice of what it was before. Having this insight allows you to review your code changes as well as think off using PHP Compilation Caching using PHP Accelerators.
Warning Signal for PHP Monitoring: A change in our deployment in combination with more traffic on April 3rd caused our PHP Compilation Time contribution to double
Key Takeaways
- Developers: Analyze compilation time of your PHP code to identify complex coding early on
- Testers: Watch out for PHP Compilation Time changes from build to build to identify regressions early on
- Operations: Use PHP Accelerators as part of your PHP deployment in order to speed up overall PHP performance
#2: Bad database access patterns
Bad database access patterns are a common theme in the blog posts we write, mainly focusing on Java and .NET Enterprise Apps. Check out DB Access Patterns Gone Wild or When It Really Is The DB To Blame.
PHP Applications face the same problems. Watch out for the N+1 Query Problem; executing the same SQL multiple times per request or requesting data with multiple SQLs instead of optimizing a single SELECT statement:
Instead of specifying a proper IN-Clause the same SQL is executed hundreds of times with different WHERE-Clause causing unnecessary DB Roundtrips
Executing the exact same SQL up to 95 times is a sign for caching the data instead of requesting it over and over again from the database
To spot these problematic access patterns in production simply monitor the number of database executions and compare them with the incoming transactions as well as total database time as shown in the following chart:
In a production environment you do not want to see many spikes in database execution count and time that don't correlate to incoming load. That would indicate a data-driven performance/architectural problem
Key takeaways
- Developers: Analyze which statements get really executed by your code as well as any third-party libraries you use to access code
- Database Engineers: Watch out for SQL Executions from PHP and sit down with engineers to optimize their SQL queries in their code. Provide guidance on SQL coding or stored procedures instead of having them execute hundreds of SELECT queries
- Testers: When executing load tests watch out for any load-related DB access patterns. Which "static" data is queried all the time and might be better off by caching it in the application?
- Operations: Monitor spikes in # of SQL Executions and whether that relates to a data-driven problem such as a user using a very exotic search term that results in too many SQL queries
For tip #3, and for further insight, click here for the full article
The 19th International Cloud Expo has announced that its Call for Papers is open. Cloud Expo, to be held November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, brings together Cloud Computing, Big Data, Internet of Things, DevOps, Containers, Microservices and WebRTC to one location. With cloud computing driving a higher percentage of enterprise IT budgets every year, it becomes increasingly important to plant your flag in this fast-expanding business opportunity. Submit y...
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The essence of data analysis involves setting up data pipelines that consist of several operations that are chained together – starting from data collection, data quality checks, data integration, data analysis and data visualization (including the setting up of interaction paths in that visualization). In our opinion, the challenges stem from the technology diversity at each stage of the data pipeline as well as the lack of process around the analysis.
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There are several IoTs: the Industrial Internet, Consumer Wearables, Wearables and Healthcare, Supply Chains, and the movement toward Smart Grids, Cities, Regions, and Nations. There are competing communications standards every step of the way, a bewildering array of sensors and devices, and an entire world of competing data analytics platforms. To some this appears to be chaos. In this power panel at @ThingsExpo, moderated by Conference Chair Roger Strukhoff, panelists will discuss the vast to...
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Internet of @ThingsExpo, taking place November 1-3, 2016, at the Santa Clara Convention Center in Santa Clara, CA, is co-located with the 19th International Cloud Expo and will feature technical sessions from a rock star conference faculty and the leading industry players in the world and ThingsExpo New York Call for Papers is now open.
May. 24, 2016 04:00 PM EDT Reads: 1,671
Designing IoT applications is complex, but deploying them in a scalable fashion is even more complex. A scalable, API first IaaS cloud is a good start, but in order to understand the various components specific to deploying IoT applications, one needs to understand the architecture of these applications and figure out how to scale these components independently. In his session at @ThingsExpo, Nara Rajagopalan is CEO of Accelerite, will discuss the fundamental architecture of IoT applications, ...
May. 24, 2016 03:45 PM EDT Reads: 576
As cloud and storage projections continue to rise, the number of organizations moving to the cloud is escalating and it is clear cloud storage is here to stay. However, is it secure? Data is the lifeblood for government entities, countries, cloud service providers and enterprises alike and losing or exposing that data can have disastrous results. There are new concepts for data storage on the horizon that will deliver secure solutions for storing and moving sensitive data around the world. ...
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SYS-CON Events announced today that Enzu, a leading provider of cloud hosting solutions, will exhibit at SYS-CON's 18th International Cloud Expo®, which will take place on June 7-9, 2016, at the Javits Center in New York City, NY. Enzu's mission is to be the leading provider of enterprise cloud solutions worldwide. Enzu enables online businesses to use its IT infrastructure to their competitive advantage. By offering a suite of proven hosting and management services, Enzu wants companies to foc...
May. 24, 2016 02:15 PM EDT Reads: 2,064
SYS-CON Events announced today the How to Create Angular 2 Clients for the Cloud Workshop, being held June 7, 2016, in conjunction with 18th Cloud Expo | @ThingsExpo, at the Javits Center in New York, NY. Angular 2 is a complete re-write of the popular framework AngularJS. Programming in Angular 2 is greatly simplified. Now it's a component-based well-performing framework. The immersive one-day workshop led by Yakov Fain, a Java Champion and a co-founder of the IT consultancy Farata Systems and...
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Customer experience has become a competitive differentiator for companies, and it's imperative that brands seamlessly connect the customer journey across all platforms. With the continued explosion of IoT, join us for a look at how to build a winning digital foundation in the connected era – today and in the future. In his session at @ThingsExpo, Chris Nguyen, Group Product Marketing Manager at Adobe, will discuss how to successfully leverage mobile, rapidly deploy content, capture real-time d...
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In his keynote at 18th Cloud Expo, Andrew Keys, Co-Founder of ConsenSys Enterprise, will provide an overview of the evolution of the Internet and the Database and the future of their combination – the Blockchain. Andrew Keys is Co-Founder of ConsenSys Enterprise. He comes to ConsenSys Enterprise with capital markets, technology and entrepreneurial experience. Previously, he worked for UBS investment bank in equities analysis. Later, he was responsible for the creation and distribution of life ...
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I don't drink milk. Milk is for babies. When you grow up, you gotta drink beer" -Arnold Schwarzenegger
HTS costs up to $300 a month to operate. We need your help!
well basically we are using the telnet function from XP to port into the hotmail mail system and then send an email.
PM if u want to find out more
hey, what was ure question, and about what post? what are u actually asking?


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The Top 10 Habits of Grateful People…Even In Tough Times
We have to admit that it is much easier to be thankful when things are going well but when life throws us a curve ball we often choose to moan and grumble (understandably so). The Top 10 Habits of Grateful People…Even In Tough Times is a great quick read on how to be grateful all the time. Check it out.
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The Top 10 Habits of Grateful People…Even In Tough Times. Follow the link for some wonderful thoughts on gratitude!
The best natural remedy - gratefulness. Blog post: The Top 10 Habits of Grateful People…Even In Tough Times
The Top 10 Habits of Grateful People…Even In Tough Times Fighting Cancer - Ewing's Sarcoma #life4rebeca www.Life4Rebeca.com
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The Top 10 Habits of Grateful People...Even In Tough Times... really, truly powerful if you click through and read the article.
The Top 10 Habits of Grateful People … Even In Tough Times. Thank You - GRATITUDE is the Key .. http://www.belovedtreasures.com.au/proddetail.asp?prod=asc-pnd-08783
Attitude of gratitude! Habits and traits of grateful people.
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I know that is the truth. I have family that don't make time for me. But if i had a lot of money, then they would make time for me. Aint nobody got time for that!!
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Time ....... so true, i have learnt this the hard way, it just shows you are not important to them
DesertRose.... So true
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My co-workers laugh at my "work ethic". Here's my thought: there are MILLIONS of people unemployed in AMERICA in 2013. I am blessed to have a job. So I'm going to work it to the best of my ability. If you're not going to work, quit and let someone who needs that job have it. There's NO EXCUSE for laziness at work!!!!!!!!!!
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Remember this💛💙💜💚❤ this is not just inspirational but it is also to be thankful to everyone around you 💙 comment something you are thankful for💖
So true! Like the people who take parenthood for granted... there are many women like myself who cannot even have children, and then many people who do, don't deserve them! Or those who take their bodies and their health for granted. Take it from me, in the blink of an eye, your health can change forever! Be thankful for your abilities, your independence, your health, your hobbies, your success thus far, because it could all easily be taken away.
So true! Someone else is happy with less than what you have. (Be thankful, for everything)
Always be grateful! I so need to remember this never looked.at it like that so true
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Great Advice #196: Don\'t sacrifice your peace trying to point out someone\'s true colors. Lack of character always reveals itself in the end.Mandy Hale: Don't sacrifice your peace trying to point out someone's true colors. Lack of character always reveals itself in the end.
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18 things to promote strong positive thinking Build up your mental strength! I know worry is hard to get past but recognize your emotions and understanding them could help mental strength. Use these tips to get yourself started. (:
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Thank You for your part in my journey :) Want to see how well you are doing with your nutritional habits? Get your FREE No Obligation Wellness Evaluation TODAY! www.WellnessScore.co.uk
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positive thoughts quotes http://www.positivewordsthatstartwith.com/ Best Friends Quotes. Positive words and inspirational quotes about friends and friendship. | @mobile9
Thank you for this wonderful adventure. Thank you for the memories that will last me for the rest of my life, I am sure. Thanks for the beautiful memories, Emily. 💗
Thank you for this wonderful adventure. Thank you for the memories that will last me for the rest of my life, I am sure.
Another Pinner Wrote: Be thankful for everyone you meet and everything you survive. Even the mean, hateful people and difficult times. Be thankful you're not them. Be thankful it wasn't worse. They all teach us something. All give us a learning experience. Just say thank you. Curve your mouth upward, relax your eyes and say thank you. #attitudeofgratitude #backinmotion.us
http://www.fashiontrendstoday.com/category/xoxo/ I am so thankful each and everyday to everyone who has helped, healed and made a difference in my life
for all the kindred spirits that I have met here.....❤ ~☆~
d0c584722c3841687828d9a2475ab7f7.jpg 600×800 pixels
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32 Best Thank You Quotes and Sayings
Be Grateful!
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Truth! | It doesn't matter if the glass is half empty or half full…Be grateful that you have a a glass and there is something in it! | inspirational quotes | words to live by | beautiful words
It doesnt matter if the glass is half empty or half full...... Be grateful that you have a glass, and there is something in it.....
It doesn't matter if the glass is half empty or half full...Be grateful that you have a glass and there is something in it...Found on Have you had your daily dose of smiles today on Facebook
Grateful for a glass.. half full or half empty is inconsequential
#Gratitude Be grateful Glass half empty or half full
Glass half full or half empty ... Be GRATEFUL ..
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Inspire people.
My Life, Thought, Help People, Life Goals, Goals In Life, Never Give Up
I want them to say, "You gave me hope when I had none." I want to inspire others and keep them smiling. Why? Because life is amazing. Forever changing and growing and blossoming into gorgeous things. Life is a beautiful thing and people should realize that
My choices in life i know have inspired people to do things. I choose to not give up and fight for myself. Im happy to share this tenacity with all I meet.
You should never give up on the people you care about. Because if he is the one, he will make you happier than you thought was ever possible.
This is literally my life goal. I don't think any one I know doesn't think I am determined to achieve this goal.
This is one of my biggest goals in life. To help people. I love helping people, I don't care if it's a stranger.
Horatio would have pinned this because it can relate to how Hamlet looks at him as a friend. Throughout the play Hamlet continuously looks and goes to Horatio for support and help with all the situation he faces in his life. Which is why I believe this quote fits well with being admiring because Horatio is the person that gave Hamlet hope to never give up on the things he believed in.
.this is why I do a lot of things I do and never give up even when things get really hard
My life goal is to just be an inspiration even if it is just to one person.
One of my goals in life is to inspire people
De stress mentally, spiritually ,physically.And be with people who take care of you as well. via | the good vibe. quotes. wisdom. advice. life lessons.
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Take care of yourself. Mentally, spiritually & physically. Surround yourself with people who take care of you as well. #quote
De stress mentally, spiritually ,physically.And be with people who take care of you as well. via | the good vibe
[ raybansunglasses.hk.to ] #ray #ban #ray_ban #sunglasses #chic #vintage #new Great to own a Ray-Ban sunglasses as summer gift.De stress mentally, spiritually ,physically.And be with people who take care of you as well. via | the good vibe
De-stress a bit! TAKE CARE OF YOURSELF.... Mentally, spiritually, physically. And be around people who help take care of you as well. via | the good vibe
Def need to remember this
Mind, body, spirit
Good advice
30 Inspirational Quotes About Gratitude
I need to remember this at times, I think it's hard for people to realize how well they have it over others.
Bad Life Quotes, Hard Time Quote, Bad Attitude Quotes, Positive Inspirational Quotes, Fairytale, Be Greatful Quote
Be thankful for what you have. Your life, no matter how bad you think it is, is someone else's fairytale. -Wale ayeni
I doubt it's anyone's fairytale to work their whole life to obtain financial freedom to have it taken by the greedy & litigious, forcing them into poverty and being treated as the lazy unintelligent people we treat our poor as, while the aggressor lives very financially secure without a care in the world, among a society that cares not how wealth is gained, but respects those who have it.
Our love is a fairytale type of love... We are just going through the difficult part of the story temporarily..
Fortunate enough to be that person living the fairytale - Having a thankful day
Or it is a fairytale and I just haven't gotten to the happily ever after yet???
...is someone else's fairytale.
Your life is a fairytale
Be Grateful ~☆~
Attraction Manifestation, Law Attraction Quotes, The Secret Law Of Attraction, The Law Of Attraction, Laws Of Attraction, Law Of Attraction Quotes
Gratitude and the law of attraction Manifestation Miracle - Click the image for more info!
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Gratitude and the laws of attraction - Pinned by The Mystic's Emporium on Etsy
Gratitude and the laws of attraction. This is very true ♡
This is true!!! Law of attraction quotes-
being thankful #lawofattraction
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Positive thought
Thank you awesome ladies for ALL of the lovely pins to this Board ♥ You guys continue to outdo yourselves here, and that means you guys ROCK!! Thank you!
Beautiful Pins, 200 Followers, Awesome People, Thank You Cards, Pinterest Followers, Thankyou Jpg
I just wanted to take a moment and say Thank You for the beautiful pins and all of the beauty they create for this small group board! 💜 Blessings, Tena.
Thank you awesome ladies and gentlemen for ALL of the lovely pins to this Board ♥ You guys continue to outdo yourselves here, and that means you guys ROCK!! Have a Lovely Day! <3 Thank you! ~ Marilyn ღ❤♡. Pretty.
Thank you awesome Pinterest ppl for 200 followers and you guys ROCK!! Thank you
Thank you to my awesome followers!! ♥ You guys ROCK!! Thank you!! xoxo
Wow 4000 followers Thank you so much to each and everyone of you :) ♥
Thank you awesome people for all your wonderful inspiring pins!
Thank you, to all my Pinterest followers!
thank you card cover art
Every single day... I have so much to be grateful for!
Quotes Motivational, Joel Osteen Quotes, Be Grateful, Motivational Quotes, Thought, Inspirational Quotes, Direction Find, Inspirations Quotes, Joelosteen
What are you grateful for today? We challenge you (especially if you're having a tough day) to comment your positive thought! #EatingDisorder #Recovery #StayPositive
beautiful quotes, inspirational quotes, motivational quotes, inspirational sayings, inspirational desktop wallpapers at www.fabulouswallpaper.com
Every day, set your mind in the right direction. Find something to be grateful for. -Joel Osteen by deeplifequotes, via Flickr
Every day, set your mind in the right direction. Find something to be grateful for. -Joel Osteen
GRATITUDE: Every day, set your mind in the right direction. Find something to be grateful for.
motivational and inspirational quotes grateful for life!
Live Life Happy - Page 209 of 925 - Inspirational Quotes and Shareable Posters
Be grateful for the things youhave in your life.
Feels Sore, Be Grateful, I'M Happy, Life Quote, Quotes Sayings, I M Happy, Its My Life, I M Thankful, Love My Life
My body sometimes feels sore, but it works. I don`t sleep well most nights, but I do wake up to fight another day. My wallet is not full but my stomach is. I don`t have all the things I ever wanted but I do have everything I will ever need. I`m thankful because although my life is by no means perfect, it`s my life and I`m happy. ~unknown
Be grateful for all that you have - My body sometimes feels sore, but it still works etc.
Love this. So true. I love my life and wouldn't have it any other way!
Inspirational quotes & sayings!
Quote: I don`t have all the things I ever wanted but I do have everything I will ever need. I`m thankful because although my life is by no means perfect, it`s my life and I`m happy. etc.,Inspirational and Life Quotes,li
Monday Inspiration - Get Happier with Nataly Kogan
10 things you can do to be happier.
Inspirational Quote, Grateful Quotes Gratitude, Positive Happiness Quotes, Happy People Quotes, Happy Life Quotes, Happy Quote, Gratitude Quotes, Happy Monday Quotes
Expectations lead to disappointments. Appreciation leads to happiness. Happiness, how to be happy, happiness quotes #quotes #happy #happiness
Wow, famous and inspirational quotes are a great tool in life. Description from pinterest.com. I searched for this on bing.com/images
#Monday #Inspiration quotes
Inspirational quotes
So true! Be unique, be you! Find what YOU love doing, don't be so quick to blend in & join the majority. If being YOU means being on your own little boat & having few "supporters", that may just be better than not being you. LOVE YOURSELF, I mean, I love you. Who wouldn't? You are fearless. The Creator of the infinite universe loves you. You are made for wonderful things.


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In 2005, approximately 130,000 Albertans had been diagnosed with diabetes. Every month, almost 1,000 new cases are added to that total.


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Teen girl helped lure woman in Edmonton trafficking case: police
CTVNews.ca Staff
Published Saturday, January 5, 2013 1:40PM EST
Last Updated Saturday, January 5, 2013 4:40PM EST
Edmonton police have laid multiple human trafficking and prostitution-related charges against three men in two separate cases involving teenage girls, including a case where police say a victim was introduced to her alleged assailants by another teen girl.
In the first case, police say a 25-year-old man helped to lure a teen girl to Edmonton from Saskatoon in July 2012.
Once she arrived in Edmonton, the girl was allegedly sexually assaulted, beaten and forced in prostitution, police say.
The girl was eventually able to escape from a motel room where she was being held against her will.
She later returned to Saskatoon, but police believe there may be more victims in connection to this case.
Ali Saghafi was arrested on Dec. 20 and charged with numerous offences, including trafficking of a person under the age of 18, procuring prostitution and living off the avails of juvenile prostitution.
In a more recent case, police allege an 18-year-old woman was held in a west Edmonton motel room and forced into prostitution by two men.
Police allege the victim in this case was introduced to the suspects by a 16-year-old girl.
"We've always created that scare about stranger danger,..we never really messaged kids to kids… and the predators among kids," said Scott Pattison, spokesman with the Edmonton Police Service,
Hamid Fazil Ghejlou, 31, and Shahin Ranjbar, 23, each face a number of charges related to prostitution and human trafficking
With files from CTV Edmonton
More News from Canada
- Toronto Transit Commission investigating after doors open on moving train
- Halifax 'pants puller' arrested on mischief charges
- Toronto Parks investigating reports of capybaras sightings
- Gursimar Bedi guilty of accessory after the fact in Maple Batalia murder
- N.S. teen finds blade in store-made cookie


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5 bedroom detached house for sale The Crescent, Cheam, Sutton, SM2A house which ranks as one of the best seen; 3,700 sq ft of indulgent luxury accommodation. The craftsmanship of the finish and the fixtures contained within are of the highest quality. A South Cheam location adds the last tick in the box . The size and open plan layout of the accommo... More details ›
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3 bedroom semi-detached house for sale Pelton Avenue, Sutton, SurreyOPEN HOUSE SATURDAY 28TH MAY 2016 - by appointment only Buyers Fees apply. Extended 3 bedroom semi-detached house. Excellent internal order, Driveway. Coveted location, Additional loft room/study More details ›
£475,000 Offers in Excess of
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Retail Property (high street) for sale Station Road, Sutton, Surrey, SM2Freehold For SaleOffice/Shop with 2-Bedroom MaisonetteOffers Sought in Excess of £475,00029 Station Road, Belmont, Sutton, Surrey SM2 6BX More details ›
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3 bedroom semi-detached house for sale Pelton Avenue, Sutton, SurreyOffered at a reduced price for the over 60s under Homewise's lifetime lease plan. Discounts range from 8.5% to 59% of the property's full market value. For example purposes, the above price is based on a single man aged 68. The actual price you pay will depend on your age and personal circumstances. More details ›
£350,000 Guide Price
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2 bedroom ground floor flat for sale The Crescent, Belmont, Sutton, SurreyOPEN HOUSE SATURDAY 4TH JUNE 2016 - by appointment only Buyers Fees apply. Chain Free! Be ready for your life to get just that little bit easier when you move into this superbly located apartment. All your local amenities not to far away life has never looked so good. More details ›
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New research has uncovered how a complex protein pivotal in the development of cancer, viral infection and autoimmune diseases is activated. The discovery answers a key question about one of the most widely-researched proteins in human biology, which has been the subject of tens of thousands of research papers and millions of pounds in research funding.
Jiazhen Zhang, a research student in Professor Sir Philip Cohen's laboratory at the University of Dundee, uncovered how the protein complex, called NF-κB, is activated. The results are published today in the Biochemical Journal.
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA. NF-κB is found in almost all animal cell types and plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development.
"NF-κB has been the subject of a vast amount of research for many years as it plays a critical role in inflammatory diseases and cancer," said Sir Philip. "It has been known for some time that the protein is activated by a kinase called IKKβ but there has been split opinion with regards to how the kinase itself is switched on.
"We have confirmed that another kinase, TAK1, is involved, but surprisingly it isn't sufficient to switch on IKKβ. Two other events need to happen in addition, namely the formation of an unusual type of ubiquitin chain and its attachment to IKKβ and then the addition of a second phosphate group on to IKKβ which remarkably is carried out by IKKβ itself. It is only then that IKKβ becomes competent to switch on NF-κB.
"This is complex biochemistry but working out the details of how proteins are switched on and off is how new ways to develop improved drugs to treat disease are identified. For example, the enzyme that makes the ubiquitin chains needed to activate IKKβ could now be targeted to develop a drug to treat inflammatory diseases."
The research was carried out in the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) at Dundee.
Peter Shepherd, Chair of the Biochemical Journal Editorial Board, said, "This signalling pathway is critical for a wide range of cellular responses, particularly stress responses. Understanding how this pathway is regulated is hugely important, and this paper finally clarifies one of the key steps in this process. This is important in not only understanding the disease process, but in the quest to develop new therapies that target this signalling pathway."
Alastair Stewart | Eurek Alert!
Further information:
Further reports about: > B cells > DNA > diseases > immune > inflammatory > pathway > responses > signalling > viral infection
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text: Technologist tag:blogs.findlaw.com,2009-03-31:/technologist/10 2016-05-27T20:19:45Z The FindLaw Legal Technology Blog. Movable Type Enterprise 4.38 http://images.findlaw.com/logo/logo_news3.gif How Government Lawyers Are Using Data Analytics tag:blogs.findlaw.com,2016:/technologist//10.55803 2016-05-27T20:15:11Z 2016-05-27T20:19:45Z Casey C. Sullivan, Esq. https://www.linkedin.com/in/sullivancasey Government agencies are usually pretty slow to adopt technological advancements. The federal Veterans Affairs Administration, to give one example, is still notoriously paper-dependent, with its non-digitized files stacked so high they could pose a safety risk to workers. And... http://blogs.findlaw.com/technologist/2016/05/how-government-lawyers-are-using-data-analytics.html Google's Paris Office Raided as Part of Tax Evasion Investigation tag:blogs.findlaw.com,2016:/technologist//10.55784 2016-05-26T18:57:47Z 2016-05-26T18:40:02Z Jonathan R. Tung, Esq. According to Reuters, French police arrived at Google Paris offices Tuesday and raided the location as part of an ongoing investigation into whether or not the Internet company is dodging taxes. The probe, opened last June, is part of an... http://blogs.findlaw.com/technologist/2016/05/googles-paris-office-raided-as-part-of-tax-evasion-investigation.html Best Tech Gadgets and Services for Lawyers on a Budget tag:blogs.findlaw.com,2016:/technologist//10.55766 2016-05-25T18:58:19Z 2016-05-25T17:19:48Z Casey C. Sullivan, Esq. https://www.linkedin.com/in/sullivancasey It costs to be on the cutting edge. When it comes to going digital, going paperless, going hi-tech, you can easily start shelling out thousands of dollars on products and services, some of which may be obsolete in a... http://blogs.findlaw.com/technologist/2016/05/best-tech-gadgets-and-services-for-lawyers-on-a-budget.html Price Gougers Beware: Vermont About to Pass 'Anti-Shkreli' Bill tag:blogs.findlaw.com,2016:/technologist//10.55751 2016-05-24T18:58:29Z 2016-05-24T18:58:32Z Jonathan R. Tung, Esq. Gougers can likely look to Martin Shkreli for ruining the game of price gouging customers by going nuts and hiking the price of a desperately needed pill some 5,555 percent. The Internet won't soon forget Shkreli's uncontrollable need to display... http://blogs.findlaw.com/technologist/2016/05/price-gougers-beware-vermont-about-to-pass-anti-shkreli-bill.html LinkedIn Was Hacked: Here's How to Protect Yourself tag:blogs.findlaw.com,2016:/technologist//10.55735 2016-05-23T18:59:41Z 2016-05-23T18:34:33Z Casey C. Sullivan, Esq. https://www.linkedin.com/in/sullivancasey Back in 2012, LinkedIn was hacked and 6.5 million passwords were reportedly leaked. Now it looks like a few more accounts were also compromised -- almost 167 million. And the consequences of that hack are still playing out four... http://blogs.findlaw.com/technologist/2016/05/linkedin-was-hacked-heres-how-to-protect-yourself.html Did Liss-Riordan Betray Uber Drivers? tag:blogs.findlaw.com,2016:/technologist//10.55718 2016-05-20T17:58:44Z 2016-05-20T17:16:09Z Casey C. Sullivan, Esq. https://www.linkedin.com/in/sullivancasey When Shannon Liss-Riordan started suing major tech companies last Spring, she was hailed as the woman who could take down "the entire on-demand economy." Uber and Lyft were her two primary targets, but companies like Amazon were in her... http://blogs.findlaw.com/technologist/2016/05/did-liss-riordan-betray-uber-drivers.html Top Social Media Tips for Attorneys tag:blogs.findlaw.com,2016:/technologist//10.55682 2016-05-18T18:55:44Z 2016-05-18T17:43:43Z Casey C. Sullivan, Esq. https://www.linkedin.com/in/sullivancasey For some lawyers, social media networks are a way to reach potential customers and build their name. For others, they're a treasure trove of helpful evidence, with the errant Facebook post becoming the modern-day smoking bullet. There's no escaping... http://blogs.findlaw.com/technologist/2016/05/top-social-media-tips-for-attorneys.html Fight Back! Steps to Take Against Cybersquatters tag:blogs.findlaw.com,2016:/technologist//10.55684 2016-05-18T17:55:40Z 2016-05-18T17:52:39Z Jonathan R. Tung, Esq. It's a war out there in cyberspace. Everyone is vying for a piece of the pie -- customer eyeballs and dollars. But what are some steps that the honest solo attorney can utilize to fight against that most annoying of... http://blogs.findlaw.com/technologist/2016/05/fight-back-steps-to-take-against-cybersquatters.html FTC, FCC Ask Mobile Companies: 'How's Mobile Security Today?' tag:blogs.findlaw.com,2016:/technologist//10.55660 2016-05-17T15:59:02Z 2016-05-16T22:59:41Z Jonathan R. Tung, Esq. Last week the FTC knocked on the doors of eight mobile device makers and asked them to provide hard answers regarding their efforts to address or patch the latest security vulnerabilities afflicting your mobile device. Simultaneously, it has also opened... http://blogs.findlaw.com/technologist/2016/05/ftc-fcc-ask-mobile-companies-hows-mobile-security-today.html Malaysia Airlines Flight Debris Likely Found, Many Months Later tag:blogs.findlaw.com,2016:/technologist//10.55661 2016-05-17T12:58:07Z 2016-05-16T22:44:26Z Peter Clarke, JD https://www.linkedin.com/pub/peter-clarke/22/825/384 FindLaw columnist Eric Sinrod writes regularly in this section on legal developments surrounding technology and the Internet. We often take for granted the amazing capabilities, power, and reliability of technology. For example, without giving it much thought, we often... http://blogs.findlaw.com/technologist/2016/05/malaysia-airlines-flight-debris-likely-found-many-months-later.html Can Automated Proofreading Software Make You a Better Writer? tag:blogs.findlaw.com,2016:/technologist//10.55653 2016-05-16T21:57:47Z 2016-05-16T21:46:13Z Casey C. Sullivan, Esq. https://www.linkedin.com/in/sullivancasey As lawyers, we're all writers. But we're not poets here, and legal writing doesn't have to be (and probably shouldn't be) best-seller worthy. It should be better, though: clear, accessible, and sometimes even enjoyable to read. And there's a... http://blogs.findlaw.com/technologist/2016/05/can-automated-proofreading-software-make-you-a-better-writer.html Who Qualifies as a Repeat Infringer of Copyrights Under the DMCA? tag:blogs.findlaw.com,2016:/technologist//10.55636 2016-05-13T19:52:36Z 2016-05-13T20:10:59Z Casey C. Sullivan, Esq. https://www.linkedin.com/in/sullivancasey Thanks to the Digital Millennium Copyright Act, online services like Facebook, Reddit, and Youtube aren't liable for the copyright violations of their users. Those companies are protected by the DMCA's safe harbor provisions, but under the terms of the... http://blogs.findlaw.com/technologist/2016/05/who-qualifies-as-a-repeat-infringer-of-copyrights-under-the-dmca.html BigLaw Firm Brings Artificial Intelligence on Board tag:blogs.findlaw.com,2016:/technologist//10.55617 2016-05-12T21:57:02Z 2016-05-12T20:40:00Z Casey C. Sullivan, Esq. https://www.linkedin.com/in/sullivancasey Welcome to the firm, robot lawyers! Last week, BigLaw firm BakerHostetler announced that it was partnering with ROSS Intelligence to bring artificial intelligence to its Bankruptcy, Restructuring, and Creditor Rights practice. ROSS will be used to help BakerHostetler's non-robot... http://blogs.findlaw.com/technologist/2016/05/biglaw-firm-brings-artificial-intelligence-on-board.html Senate Demands Answers About 'Bias' in Facebook News Trends tag:blogs.findlaw.com,2016:/technologist//10.55591 2016-05-11T21:58:49Z 2016-05-11T20:27:42Z Jonathan R. Tung, Esq. If the accusations of Facebook's former news curator are to believed, the social media company's news platform isn't quite as neutral as many people have come to believe. Yesterday, the US Senate Committee called for Facebook Chairman Mark Zuckerberg to... http://blogs.findlaw.com/technologist/2016/05/senate-demands-answers-about-bias-in-facebook-news-trends.html Top 5 Things Lawyers Need to Know About Email Security tag:blogs.findlaw.com,2016:/technologist//10.55583 2016-05-11T18:57:11Z 2016-05-11T17:15:19Z Casey C. Sullivan, Esq. https://www.linkedin.com/in/sullivancasey Humanity (and humanity's spambots) send out over 196 billion emails ever day. Your share is probably a few dozen -- maybe 100 or so if you're unlucky. Email has fast become one of the primary ways we communicate, whether... http://blogs.findlaw.com/technologist/2016/05/top-5-things-lawyers-need-to-know-about-email-security.html


text:
Unlimited Marine Services, Inc. (UMSI), a full service marine technology company continues to expand with the recruitment of Scott MacDonald as Director of Sales.
Scott MacDonald will be running the Sales Department, responsible for business development for the megayacht division.
Scott MacDonald has over 20+ years of sales experience in the maritime industry, working for a host of different organizations, including KSM Consulting, Orbit CT&T, and HMS. Scott has experience with yacht construction, refits, systems integration, dealerships, shipyards, electronics, satellite communications and marine entertainment.
Maritime Today
The Maritime Industry's original and most viewed E-News Service
U.S. shipbuilder General Dynamics NASSCO hosted a keel laying ceremony on Thursday, May 26 for the Liberty, one of three new ECO Class Jones Act tankers under a
DSC Dredge, LLC, based in Reserve, La., has received the 2016 President's "E-Star" Award for exports.
In a ceremony held on May 16, 2016, at the U.S. Department
TT Club has announced its financial results for the year ended December 31, 2015, and AM Best affirms its A- (Excellent) rating for the 10th consecutive year.
Knud Pontoppidan,
The London P&I Club says it continues to see cases of injuries and fatalities associated with entry into enclosed onboard spaces, including cargo holds on bulk
Videotel, producer and distributor of training videos, 3D animation, and e-Learning courses to the maritime market and part of KVH Industries, Inc., (Nasdaq: KVHI),
EPA Tier 4 regulations (for engines of 804 hp and higher) and propulsion advancements have many manufacturers and vessel designers changing course to adapt to new requirements and customer demands.
Leonhardt & Blumberg was founded in 1903 and has managed more than 180 vessels, the majority of which were general cargo vessels and bulk carriers. Today the company
China's Zoomlion Heavy Industry Science and Technology Co Ltd has abandoned its $3.4 billion bid for U.S. crane maker Terex Corp , clearing the way for a smaller
The Royal Thai Navy has ordered a new 90-m offshore patrol vessel (OPV) to be constructed at Mahidol Adulyadej naval dockyard in Sattahip.
The newbuilding, an improved River-class design,


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text:
FIFA has said there has been no evidence that match-fixing has taken place at the World Cup.
German publication Der Spiegel claimed that convicted match-fixer Wilson Raj Perumal correctly called the outcome of Croatia's 4-0 win over Cameroon in the group stages of the Brazil showpiece in a conversation on Facebook with the magazine.
Der Spiegel also claimed that Perumal indicated to them a Cameroon player would be sent off in the first half, with Alex Song subsequently dismissed five minutes before the break.
For his part, Perumal has strenously denied those suggestions, while Der Spiegel continue to stand by their report.
But at a news conference on Wednesday, the world governing body called on the magazine to bring forward evidence to support the allegations.
FIFA's head of media, Delia Fischer, told a news conference in Rio: "We have requested Der Spiegel to provide us with all the communications with Perumal and any other material in order to prove the allegations they have made.
"So far we have no evidence of any match manipulation on the betting market. The media and other stakeholders should not call people's or organisation's credibility into question just for headlines.
"It is really important to make sure that information is handled with the necessary respect and care."
In his statement, Perumal said: "Contrary to the 'revelations' published by the German weekly Der Spiegel that were picked up by news outlets worldwide, I did not predict the result of the Cameroon v Croatia match played on June 18, 2014.
"The Facebook chat with the Der Spiegel journalist took place a few days after the match – 21 June, as confirmed by my Facebook log – and was but an informal assessment of the behaviour of the Cameroon team at the Brazil 2014 World Cup after they had played two of their three group stages matches, including the one with Croatia.
"At no time did I make reference to four goals being scored or to a red card being issued.
"At no time did I suggest that I had any way of corroborating or substantiating what was meant to be an educated guess based on my extensive match-fixing experience.
"I am shocked and amazed that a respected magazine such as Der Spiegel would go so far as to fabricate statements by yours truly with the visible aim of stirring the row over match-fixing.
"I apologise to the Cameroon FA and to its fans if I inadvertently offended them. It was not my intention."
The Cameroon Football Federation (FECAFOOT) confirmed earlier this week it had launched an investigation into the claims.
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