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This username must be unique, cannot be edited and will be used in the URL to your profile page across the entire 24.com network.
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Bodaboda motorcyclists have been ordered to observe
safety measures while conducting their business following an accident that
occurred early this week involving a motorcyclist and a vehicle in a hit and
run accident along Meru-Nanyuki Highway.
Confirming the incident Imenti North OCPD James Kithuka
said the rider, Eric Juma was left with a broken limb and he is recuperating at
Meru Level Five Hospital.
Kithuka said 3 passengers on board aged between 10-13
years sustained minor injuries but were treated and discharged at Meru Level
Five Hospital.
The police boss blamed on motorcyclists whom he said were
flouting common traffic rules like carrying more than one passenger.
"In fact a motorbike is meant to carry only two people;
the rider and one passenger," he retorted.
He further reminded the boda boda operators to embrace
putting on helmets and other protective wears to avert injuries in case of an
Kithuka said the driver involved in the accident is on
tracking urging anybody with information to alert the police.
Similarly the OCPD has appealed to area Kenya Highway
Authority to clear the roadside bushes along Meru-Nanyuki Highway for security
In another incident early this week a public service
vehicle veered off the newly tarmacked Meru-Marimba road killing the driver on
the spot.
Kithuka confirmed that there was only one passenger on
board but he was not injured.
The police boss suspected the accident to mechanical
failure though further investigations have been launched.
Similarly the OCPD has appealed to area Kenya Highway
Authority to clear the roadside bushes along Meru-Nanyuki Highway for security reasons.
Disclaimer: News24Kenya encourages freedom of speech and the expression of
diverse views. The views of columnists published on News24 are
therefore their own and do not necessarily represent the views of
- News24Kenya
Read News24's Comments Policy
Opposition leader Raila Odinga is collecting funds from financiers to oil his 2017 presidential campaign.The star has revealed that Raila has set up an E-Fundraising and Resource Mobilisation. Read more...
Trouble is brewing over the Uhuru Park venue over who will use it on June 1. Read more...
Herds of livestock stolen from herders in Ambalo grazing area, Sololo sub-county in Marsabit County have been recovered in neighbouring Ethiopia. Read more...
CORD leader Raila Odinga is expected at the Coast at the weekend to grace a bursary disbursement function organized by Mombasa County government. Read more...
The Agha Khan University Hospital has signed a Memorandum of Understanding (MOU) with Murang'a County Government on improving healthcare services in the County. Read more...
Neptune Teezeh is a fast-rising musician in Kenya. He dropped "Nikiwa nawe" single and followed it with the official music video and both were a hit. Read more...
Police at Mtwapa in Kilifi County are detaining a 35 year old man and six underage girls for indulging in group sex. Read more...
4 things you should never do after a break-up Read more...
Three people have died following a road accident involving two motorbikes at Kangu location in Mwea, Kirinyaga County. Read more...
Former President Mwai Kibaki's long time friend, Emmanuel Karanja Mwangi, 84, has been buried in his Othaya home at Chinga village, Nyeri County. Read more...
There was a bizarre incident in Kiambugi village, Murang'a County a family found tombstone at the grave of one of their kin who was buried last week removed and planted in their neighbour's land. Read more...
Based on everything you see in the media and hear from your peers, it is almost assumed that anyone dating is also having sex. Read more...
Nakuru east district commissioner Thomas Sankei has said that this year's Madaraka day will be the most memorable in the country's history. Read more...
A security team from Murang'a County has discovered an illicit liquor manufacturing plant at Kimorori area near Kenol market, Maragua constituency. Read more...
A farmer near Isiolo-Meru boarder has surrendered his G3 rifle with 40 rounds of ammunition to the police as a way of restoring peace in the volatile boarder area. Read more...
Nakuru Council of Elders now say that the anti-IEBC demos are aimed at discrediting DP Ruto and ensure he doesn't succeed President Uhuru Kenyatta in 2022. Read more...
The Governor says MCAs have gone to Mombasa to plan his ouster following a fallout. Read more...
The guns were in the hands of herders in Baringo, Pokot, Turkana and Samburu counties. Read more...


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Lung Disease & Respiratory Health Center
Medical Reference Related to Lung
Severe Acute Respiratory Syndrome (SARS) - Treatment Overview
Doctors use antibiotics to treat pneumonia caused by bacteria, the most common cause of the condition. You usually will continue to take antibiotics for 5 to 14 days, although you may take them longer if you have an impaired immune system.
Severe Acute Respiratory Syndrome (SARS) - When To Call a Doctor
Call 911 or other emergency services immediately if you think you have symptoms of pulmonary embolism.
Severe Acute Respiratory Syndrome (SARS) - What Increases Your Risk
Respiratory syncytial virus (RSV) infects almost all children by the age of 2, and reinfection throughout life is common. The first RSV infection is usually the most severe. The virus spreads easily and is extremely difficult to completely avoid.
COPD: Clearing Your Lungs
COPD (chronic obstructive pulmonary disease) is a long-term illness that makes it hard to breathe, but learning to clear your lungs may help you save energy and oxygen, and help prevent lung infections.
Lung Function Tests
Lung function tests (also called pulmonary function tests, or PFTs) evaluate how well your lungs work.
Tuberculosis (TB) - Topic Overview
Information on pulmonary embolism, the sudden blockage of an artery in the lung.
Severe Acute Respiratory Syndrome (SARS) - Topic Overview
Postural drainage and chest percussion are often used together to help loosen and remove mucus from the lungs. These airway clearance techniques help people who have a spinal cord injury, cystic fibrosis, or another condition that makes it hard for mucus to drain from the lungs. When mucus collects in your lungs, it increases your risk for lung infections.Postural drainage uses gravity to help drain mucus into the mouth by placing the body in specific positions. Each position drains different areas (lobes) of the lung. The mucus can then be spit or coughed out.Chest percussion (chest physiotherapy) uses clapping of the chest with a cupped hand to vibrate the airways in the lungs. This vibration moves the mucus from smaller airways into larger ones where it can be coughed up. Chest percussion is done with the help of a partner, special electronic devices designed to vibrate the chest, or other instruments that a person can use to vibrate the chest safely.A doctor or respiratory
COPD: Handling a Flare-Up - Topic Overview
Spirometry is the best test to assess lung function. It often is used to evaluate a person who has a chronic cough and sputum ( mucus ) production and a history of risk factors for chronic obstructive pulmonary disease (COPD),even if shortness of breath is not present. It is also used to determine whether a specific therapy has improved lung function or whether your lung disease is getting ...
Severe Acute Respiratory Syndrome (SARS) - Fran's story
I was so scared when the doctor told me I had emphysema. I was afraid to go anywhere or do anything. I plunged into a big black hole of depression. Someone told me to go online and hook up with a support group. I did,and it literally changed my life. I was pretty shy at first,and all I did was read what everyone else was writing. Then one day I was having trouble with the company that ...
Pulmonary Embolism - Prevention
There are a number of steps you can take to help prevent getting pneumonia. Stop smoking. Smoking makes it more likely you will get pneumonia. Avoid contact with people who have respiratory tract infections, such as colds and influenza (flu).


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Runway To Red Carpet: Jessica Biel Does Her Twist On Versace
It's no secret that Jessica Biel can bring it, style-wise. The newly minted Mrs. Timberlake clearly has her pick of all things haute couture (we're still reeling over this summer's stunning baby pink Dior number), and she puts it to good use. For her latest foray into designer duds, Biel chose something a little racier, baring it in Versace at the premiere of Playing For Keeps.
While we normally think that the girl can do no wrong (that porcelain skin doesn't hurt!), we're finding ourselves a little unsure about this look. We appreciate the careful tailoring (nip-slip nation is no place for a married lady), but there's just something about this ensemble that feels off — the runway version felt fresh and vibrant, but Jess' take falls somewhat flat. Maybe we're still harboring some jealousy over losing the man of our dreams to her, but we're totally undecided.
What do you think: Is Jessica rocking this one-shoulder, or is it more ho-hum?
Photo: Erik Pendzich/Rex USA
- Entertainment |
- News |
- Red-Carpet Spotlight | Jessica Biel Versace Dress - Playing For Keeps
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Khloé Kardashian opened up in a big and bold way on this week's episode of Kocktails With Khloé. The talk show host and reality star shared that she ...
Carolyn L. Todd
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Let's Talk About Woody Allen
In September 1993, Connecticut State Attorney Frank Maco declared that he would not prosecute Woody Allen in court for the charges of sexual abuse of a child. He did, however, publicly declare that he had both probable cause and evidence that such abuse had taken place
Kelsey Miller
May 12, 2016


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FRI NIGHT VID: Brooke Raboutou - 8c Aged 11by Jack Geldard - UKC Chief Editor Feb/2013
This news story has been read 8,405 times
It is no surprise that with a climbing pedigree like that Brooke has redpointed the difficult limestone sport route of Welcome To Tijuana (8c) in Rodellar, Spain at the tender age of 11!
In this video we see Brooke in action on the rock, in the family home, and we meet her parents.
Here's the video portrait of Brooke:
"11-year-old Brooke Raboutou is a rock climbing phenom who regularly breaks world records on elite bouldering and sport climbs once thought impossible for someone her age. With two former world champion climbers for parents and coaches, Brooke's pedigree is unmatched. Now she has set her sights on pushing both herself and the climbing world to even greater heights."
As reported yesterday, James McHaffie and Ryan Pasquill onsighted John Dunne's The Great Escape E8 (6b, 6c, 6b) at Cioch... Read more
After a multi-year on and off siege, Jon Cardwell has repeated Chris Sharma's Biographie (a.k.a. Realization), 9a+, at... Read more
Last year's Bronze medalist at the Junior Lead World championships, Julia Chanourdie, has repeated Alberto Gnerro's L'avaro, 8c+,... Read more
13 year old Brooke Raboutou has repeated Fragile steps in Rocklands, SA, her first ~8B. The problem crosses a roof via... Read more


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Legend of Pancho Barnes and the Happy Bottom Riding Club The film chronicles the thrilling life and extraordinary times of aviation pioneer Florence Lowe "Pancho" Barnes, one of the most colorful and accomplished women pilots of the early 20th century. Narrated by Tom Skerritt, with Kathy Bates as the voice of Barnes, it employs newly discovered personal files, never-before-seen photos and rare movie footage to tell her story. The film also includes interviews with General Charles 'Chuck' Yeager, astronaut Buzz Aldrin, and famed test pilots R.A. 'Bob' Hoover and Bob Cardenas.G
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Final Hours: Amelia Earhart's Last Flight Filmed in 19 countries, this documentary recreates the final flight of Amelia Earhart, the noted aviation pioneer whose historic 1937 trip around the world ended in her tragic disappearance.G
7:00 pm
Virginia Lee Burton: A Sense of Place This celebrates the career of Virginia Lee Burton (1909-1968), the groundbreaking author-illustrator of the beloved picture books Mike Mulligan and His Steam Shove land the Caldecott Award-winning The Little House. The documentary paints a portrait of a Renaissance woman ahead of her time, whose art and literature remains an enduring part of America's cultural heritage.G
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Nightly Business Report Tonight on Nightly Business Report, our Market Monitor tells us small cap names poised for big time gains. And, the latest type of identity theft you need to know about. D
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11:00 pm
Final Hours: Amelia Earhart's Last Flight Filmed in 19 countries, this documentary recreates the final flight of Amelia Earhart, the noted aviation pioneer whose historic 1937 trip around the world ended in her tragic disappearance.G


text:
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I currently have 4 loving Cocker Spaniel puppies available to find their forever home. We have 3 females and 1 male, the females are white and buff and the male is black and white one. All are updated on there shots, dewormed and have their tales docked. The females are extremely layed back and just love to be held and cuddled; while the boy is more adventurous and curious. We have raised ...
May 27 -
Indianapolis :
Noblesville - Dogs & puppies
Cocker Spaniel Puppy AKC with CH pedigree Male Dewormed at 2,4,6,&8 weeks Puppy Vaccinations Tail docked & dew claws removed DOB 12-11-15 Raised with my three year old toddler. We have finally decided which puppies from the litter we are keeping & have these three boys available!! They are ready to go to their new homes now. Pet pricing is $450 & FULL AKC is $650.
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May 23 -
Knoxville :
Oliver Springs - Dogs & puppies
Hampton & Sadie's baby boys!! Will be ready for pick up on June 11th. Puppies' tails are docked. They'll each come dewormed at 2,4,6,&8 weeks, with age appreciate vaccines, & their registration documents. Each baby will also go home with a gift bag of goodies to get you started, included is a sample of their current food. Price is $450. Deposit is $100, $350 due at pick up. Please text or ...
May 18 -
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Harriman - Dogs & puppies
We are looking for good homes for our healthy happy puppies! They will be 8 weeks by mid June.
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May 15 -
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Lady & Hampton's Baby Boys 4 available (Picks are made at 8 weeks, at my home, in order of deposits) Will be ready for pick up on June 4th. Puppies' tails are docked. They'll each come dewormed at 2,4,6,&8 weeks, with age appreciate vaccines, & their registration documents. Each baby will also go home with a gift bag of goodies to get you started, included is a sample of their current food. ...
Apr 30 -
Knoxville :
Harriman - Dogs & puppies
AKC Cocker Spaniel Pup. 7 weeks, female. Blonde. Tail Docked, Dews removed. 1st shots, de-wormed, puppy kits. Gentle/Loving,parents on site,raised in home, ready for her forever homes. 500.00 (cash)
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Apr 29 -
Atlanta :
Blairsville - Dogs & puppies
AKC Certified Puppies, born 4/19/2016 and ready for their new home after May 31st.
Total of 10 puppies in this litter!!! 4 of them were pre-sold, prior to birth
Had initial Vet Visit on 4/22 with good health report on all the puppies.
Below is what the total count is in the litter, but not necessary what is available, since the presale buyers get first choice.
Black 3 males and 2 ...
Apr 24 -
St. Louis :
Hillsboro - Dogs & puppies
Beautiful and healthy 7 week old spanador puppy. (1/2 cocker spaniel 1/2 Labrador) she is utd on shots and worming and is being crate trained. She is great with other let's and children and would make a wonderful addition to any family.
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London - Dogs & puppies
Beautiful male puppy born Dec 29. He loves children an all dogs..inside dog beautiful chocolate coat with amber eyes...I have pedigree an papers..
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Beautiful Puppy,, great with children and other dogs.. He has a wonderful personality.. Loves to snuggle.. He was born Dec. 29th. Beautiful Chocolate coat with amber eyes... I have pedigree papers & Akc papers. Please email with any questions.. This site is not letting me upload pictures.. Can send pics by email
AKC & CKC REG. Cocker Spaniel Puppies.
will be UTD on shots & wormings
tails docked & dewclaws removed
Deposit of $100 to hold puppy
Apr 13 -
Charleston (WV) :
Elizabeth - Dogs & puppies
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text:
|Publication number
|Publication type
|Application number
|Publication date
|Feb 14, 1978
|Filing date
|Mar 10, 1976
|Priority date
|Mar 12, 1975
|Also published as
|Publication number
|Jean R. Quelet
|Original Assignee
|Laboratoire Le Brun S.A.
|Export Citation
|BiBTeX, EndNote, RefMan
|Patent Citations (2), Non-Patent Citations (3), Referenced by (4), Classifications (7)
|External Links: USPTO, USPTO Assignment, Espacenet
This invention relates to 8-amino-theophylline derivatives and to their therapeutic applications.
The new compounds of this invention have the following general formula: ##STR2## in which A is a straight- or branched-chain alkylene radical having 2-4 carbon atoms in the straight portion; B is a straight- or branched-chain alkylene radical having 2-6 carbon atoms in the straight portion; X and Y, which may be the same or different, represent each a hydrogen atom, an alkyl group having 1-6 carbon atoms or a phenoxy alkylene group having 1-6 carbon atoms in the alkylene moiety; R represents a halogen atom, an alkyl group having 1-6 carbon atoms, an alkoxy group having 1-6 carbon atoms or a trifluoromethyl group; and R' represents a hydrogen atom, a halogen atom, an alkyl group having 1-6 carbon atoms, an alkoxy group having 1-6 carbon atoms or a trifluoromethyl group.
The invention includes also within its scope the acid addition salts of the compounds of the formula (I) with inorganic or organic acids.
A process for the preparation of compounds of the formula (I), comprises condensing a substituted piperazine having the formula: ##STR3## in which X, Y, R and R' have the above-defined meanings, with a derivative having the formula: ##STR4## in which A and B have the above-defined meanings and Z is a halogen atom.
The condensation reaction is generally effected by melting both reagents together.
The derivatives of the formula (III) are prepared by condensing an amino-alcohol with a 7-(haloalkyl)-8-halotheophylline (M. ECKSTEIN), Dissertationes Pharm., 14, 435-41 (1962)! followed by halogenation of the hydroxyl chain, according to the reaction: ##STR5##
The substituted piperazines of the formula (II) used as starting materials are obtained typically by condensing bis-(β-hydroxyalkyl)amines with substituted anilines of the formula: ##STR6## in hydrochloric acid medium.
The following non limiting Example is given to illustrate the preparation of the compounds of this invention.
A mixture of 9-(β-hydroxyethyl)-1,3-dimethyl-6,7,8,9-tetrahydropyrimidino(2,1-f)purine-2,4(1H,3H)-dione (7g) and thionyl chloride (25 ml) is left aside overnight. The excess thionyl chloride is evaporated off and the resulting material is hydrolyzed in 5N sodium hydroxide (200 ml). The material is then extracted with chloroform, washed with water and dried over sodium sulfate, after which the solvent is evaporated off, to give 5,3 g of chlorinated derivative. M.p. (inst.)= 212� C.
5.75 g of the chlorinated derivative obtained in a) is condensed with 7.5 g m-chlorophenylpiperazine, by fusing at 180�-190� C during 2 hours. When the condensation is complete, water (50 ml) is added and the resulting material is heated at the boiling temperature, during 15 minutes. The resulting precipitate is filtered, washed with water and recrystallized from ethanol, to give 4.7 g 9-(2- 4-(m-chlorophenyl)piperazin-1-yl!-ethyl)1,3-dimethyl-6,7,8,9-tetrahydropyrimidino(2,1-f)-purine-2,4-dione. M.p. (inst.)= 184� C.
The following Table describes, as Examples, a number of compounds of the formula (I) prepared according to the general procedure of the above example, together with their physical characteristics.
Table I__________________________________________________________________________Com-pound M.P. U.V. SpectrumNo. A B X Y R R' � C ∵max;nm (ε)__________________________________________________________________________ 1 CH2 --CH2 CH2 --CH2 H H 3-CH3 H 211� 250(1.30�104);3 00(1.51�104) 2 CH2 --CH2 CH2 --CH2 H H 3-CH3 4-CH3 192� 246(1.66�104);3 00(1.75�104) 3 CH2 --CH2 CH2 --CH2 H H 3-OCH3 H 204� 249(1.38�104);3 00(1.51�104) 4 CH2 --CH2 CH2 --CH2 H H 4-OCH3 H 177� 244(1.75�104);3 01(1.70�104) 5 CH2 --CH2 CH2 --CH2 H H 3-CF3 H 198� 254(1.86�104);3 02(1.89�104) 6 CH2 --CH2 CH2 --CH2 H H 3-F H 181� 253(2.25�104);3 00(1.68�104 ) 7 CH2 --CH2 CH2 --CH2 H H 4-F H 249� 240(1.28�104);2 99(1.48�104) 8 CH2 --CH2 CH2 --CH2 H H 3-Br H 211� 253(1.53�104);3 02(1.60�104) 9 CH2 --CH2 CH2 --CH2 H H 3-I H 206� 255(1.58�104);3 01(1.65�104)10 CH2 --CH2 CH2 --CH2 H H 2-Cl H 192� 252(1.19�104);2 98(1.49�104) 11+ CH2 --CH2 CH2 --CH2 H H 3-Cl H 29� 252(1.60�104);2 98(1.46�104)12 CH2 --CH2 CH2 --CH2 H H 4-Cl H 202� 247(1.19�104);3 00(1.50�104)13 CH2 --CH2 CH2 --CH2 H H 2-Cl 3-Cl 217� 257(1.46�104);3 01(1.48�104)14 CH2 --CH2 CH2 --CH2 H H 3-Cl 4-Cl 218� 257(1.49�104);2 64(1.53�104) 302(1.49� 104)15 CH2 --CH2 CH2 --CH2 H H 3-Cl 5-Cl 199� 264(1.70�104);3 01(1.63�104)16 CH2 --CH2 CH2 --CH(CH3) H H 3-Cl H 173� 254(1.75�104);3 00(1.68�104)17 CH2 --CH2 CH2 --CH2 --CH2 H H 3-Cl H 142� 2654(1.72�104); 300(1.72�104)18 CH2 254(1.72�CH2 --CH2 CH2 --CH2 H H 3-Cl H 184� 256(1.34�104);3 00(2.11�104)19 CH2 --CH2 --CH2 CH2 --CH(CH3) H H 3-Cl H 196� 255(1.54�104);3 01(2.03�104)20 CH2 --CH2 --CH2 CH2 --CH2 --CH2 H H 3-Cl H 203� 256(1.35�104);3 00(2.13�104)21 CH2 --CH2 CH2 --CH2 3-CH3 H 3-Cl H 176� 258(1.82�104);3 02(1.75�104)22 CH2 --CH2 CH2 --CH2 3-CH3 H 4-Cl H 164� 248(1.86�104);3 02(1.61�104)23 CH2 --CH2 CH2 --CH2 3-CH3 4-CH3 3-Cl H 164� 256(1.47�104);3 02(1.56�104)24 CH2 --CH2 CH2 --CH2 3-Et H 3-Cl H 149� 257(1.85�104);3 00(1.79�104)25 CH2 --CH2 CH2 --CH2 3-CH2 --Oφ H 3-Cl H 113� 254(2.25�104);3 02(1.42�104)26 CH2 --CH2 --CH2 --CH2 CH2 --CH2 H H 3-Cl H 171� 254(1.48�104);3 00(1.96�104)27 CH2 --CH2 --CH2 --CH2 CH2 --CH2 --CH2 H H 3-Cl H 116� 254(1.70�104);3 00(2.13�104)28 CH2 --CH2 --CH2 CH2 --CH2 --CH2 H H 4-Cl H 203� 254(1.86�104);3 01(2.08�104)29 CH2 --CH2 (CH2)6 H H 3-Cl H 182� 255(1.57�104);3 00(1.54�14)30 CH2 --CH2 --CH2 (CH2)6 H H 3-Cl H 156� 254(1.48�104);3 00(2.00�104)31 CH2 CH2 CH2 --CH2 H H 3-Cl H 255� 254(1.74�104);2 98(1.36�104)__________________________________________________________________________ +as the hydrochloride
This invention includes also within its scope a therapeutic composition having, in particular, a psychotropic and anti-inflammatory activity, comprising as active ingredient a compound of the aforementioned formula (I) or a therapeutically acceptable acid addition salt thereof.
The results of a toxicological and pharmacological investigation carried out with the compounds of the formula (I) are set forth below.
Acute toxicity in mice by the sub-cutaneous and oral routes and in rats by the oral route was investigated by determination of the death rate following a single administration of increasing dosages.
TABLE II______________________________________ACUTE TOXICITYCompound MICE LD50 mg/kg RATSNo. s.c. route oral route oral route______________________________________1 >300 >300 >1002 >300 >300 >1003 >300 >300 >1004 >300 >300 >1005 >300 >300 >1006 >300 >300 >1007 >300 >300 >1008 >300 >300 >1009 >300 >300 >10010 >300 >300 >10011 >300 450 100012 >300 120 >10013 >300 >300 >10014 >300 >300 >10015 >300 >300 >10016 >300 >300 >10017 >300 >300 >10018 >300 >300 >10019 >300 >300 >10020 >300 >300 >10021 >300 >300 >10022 >300 >300 >10023 >300 >300 >10024 >300 300 > 10025 >300 >300 >10026 >300 >300 >10027 >300 >300 >10028 >300 >300 >10029 >300 >300 >10030 >300 >300 >10031 >300 150 >100______________________________________
Symbol > means that the LD50 is not attained at the dosage indicated.
Oral subacute toxicity in rats was investigated by determination of the death rate (if any), of the change in the weight of some organs, and by hematologic examinations, and the like.
No fatal issue was noted and the change in weight was normal up to a daily dosage of 100 mg/kg. Similar results were obtained with the other parameters investigated: examination of the blood (red cells, leukocytes, differential leukocyte count, hemoglobin, coagulation time), and weight of some organs (liver, kidneys, spleen, surrenal gland, gonads).
The psychotropic and anti-inflammatory effects of the derivatives of this invention were investigated according to several methods described hereinafter.
The motor-stimulant or -depressant activities were investigated in mice by the sub-cutaneous or oral routes by means of an activometric technique (light-beam activometer).
The dosages which increase or decrease the number of cases over the 50% limit were determined with respect to concomitantly effected reference tests.
Investigation of such activities demonstrated the sedative action of the compounds of this invention, particularly in the case of compound No. 18 which exhibits an AD50 of 7.5 mg/kg.
Were determined:
a. aggressiveness subsequent to electric shocks in mice and rats,
b. aggressiveness subsequent to apomorphine injection (1 mg/kg, in vivo) in rats,
c. aggressiveness subsequent to extended isolation, in mice,
d. aggressiveness in mice-killing rats.
In all cases, the AD50 values were determined by the oral route.
All the compounds tested exhibit an anti-aggressive activity, particularly compounds Nos. 11, 3 and 18. The results obtained with the tests effected with these compounds are given in following Table III.
TABLE III______________________________________ Oral AD50 mg/kg No. 11 No. 3 No. 18______________________________________Electric shock in mice 30 30 15Electric shock in rats 45 100 45Apomorphine, in rats 140 180 85Mice-killing rats 50 -- 22Isolated mice 10 25 9______________________________________
The technique used was that of the carrage enin-induced edema in rats (oral route). The dosage which inhibits this edema by a factor of 50% was evaluated by interpolation.
Compounds Nos. 12 and 20 were found to be the more active, the activities being substantially equivalent to those of phenyl butazone.
The following tests were carried out:
a. writhing test in mice, by the oral route (on intraperitoneal administration of acetic acid),
b. hot-plate test: licking reflex in mice on a plate heated at 65� C.
The compounds exhibit an antalgic activity, the more active being compound No. 18 which exhibits an AD50 of 13 mg/kg on administration of acetic acid and of 8.5 mg/kg in the hot-plate test (licking reflex).
This activity was determined according to the technique of the bronchospasm induced by histamine injection in guinea-pigs.
Among the compounds of this invention, the more active compound is compound No. 12 which exhibits an oral AD50 of 1.5 mg/kg.
Compound No. 12 is the most active compound investigated.
The following effects of the compounds of this invention were also investigated:
a. Incapacitating effect: rotarod test in mice.
b. Anti-reserpine effect on temperature and ptosis.
c. Anti-convulsant effect with respect to cardiazol in mice.
d. Effect on narcosis induced by pentobarbital and ethanol in mice.
e. Effect on stereotypy induced by apomorphine injection in rats.
f. Effect on learning in rats: Shuttle-box test.
It should be noted that compound No. 11, which exhibits activities which, in most cases, are superior to those of chlordiazepoxide in the anti-aggressive tests does not, as the latter compound, exhibit incapacitating, anti-convulsant, pentobarbitalor ethanol-induced narcosis-potentiating, or learning-delaying effects. Superior to Imipramine in the mice-killing test in rats, it is to be distinguished from this material by its absence of anti-reserpinic effect. It is also free from typical neuroleptic effects: absence of apomorphinic anti-stereotypy, of catalepsy and of ptosis.
Compound No. 18, which has the same characteristics, is, however, more sedative and more antalgic and potentiates ethanol-induced narcosis. Another noteworthyl difference, with respect to compound No. 11, is its antagonistic activity on the group toxicity of amphetamine in mice (AD50 20 mg/kg).
It is apparent from the results of the above investigations that the compounds of this invention possess a psychotropic activity and an anti-inflammatory activity.
The therapeutic composition of this invention may be formulated, for oral administration, as tablets, drops, drinkable solutions. It may also be formulated for rectal and parenteral administration according to the suitable conventional techniques.
Each unit dose may advantageously contain from 1 mg to 100 mg active ingredient.
In view of its psychotropic activity, the therapeutic composition of this invention is applicable to the treatment of psychoses and neuroses.
|Cited Patent
|Filing date
|Publication date
|Dec 29, 1967
|Jul 22, 1969
|En Nom Collectif Science Union
|Purine compounds
|Nov 22, 1967
|Aug 5, 1969
|Troponwerke Dinklage & Co
|Theophylline and theobromine,their salts and processes for the production thereof
|Kleine et al., C. A., vol. 74, 141704x (1971).
|Kochergin et al., "Chem. Abst.", vol. 74, 1971, Abst. No. 125638y.
|Kubota et al., Chem. Abst., vol. 71, 59503k (1969).
|Citing Patent
|Filing date
|Publication date
|Nov 7, 1978
|Oct 14, 1980
|Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
|Condensed purine derivatives useful for improving peripheral circulation
|Jul 16, 1985
|Jul 8, 1986
|Eisai Co., Ltd.
|Antiphlogistic/antipyretic/analgesic agents containing theobromine or theophylline derivatives as active ingredient
|Jun 1, 1995
|Apr 14, 1998
|Istituto Ricerca Francesco Angelini S.P.A.
|Alkyl derivatives of trazodone with CNS activity
|Jan 24, 2003
|Aug 28, 2003
|Baoqing Gong
|Tricyclic compounds and their uses
|U.S. Classification
|514/220, 544/251, 514/252.16, 544/395
|International Classification
|Cooperative Classification
|European Classification


text:
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Where to see discounted movies:
"Mandela: Long Walk to Freedom"
It's new at the Crest Cinema. Also there: "Anchorman 2: The Legend Continues," "The Book Thief," "Captain Phillips" and "Thor: The Dark World" ($3-$4.50).
"The Book Thief"
- Power restored after major, hour-long outage in downtown Seattle
- Trump, Clinton win Washington state primary
- Designed in Seattle, this $1 cup could save millions of babies
- Boeing plans hundreds of layoffs in local IT unit
- Walkoff magic! Leonys Martin's dramatic homer in ninth lifts Mariners
Most Read Stories
It's new at the Admiral Theater in West Seattle. Also there: "Anchorman 2: The Legend Continues" and "The Hunger Games: Catching Fire" ($5.75).
"The Lego Movie" and "August: Osage County"
They continue at the Varsity Theatre. Also there: "Frozen" and "12 Years a Slave." All seats on Tuesday are $7.
"The Monuments Men"
It continues at the Big Picture Seattle. The 3:30 p.m. show Friday and Saturday, the 1 and 3:30 p.m. shows Sunday and the 6 p.m. shows Monday-Thursday are $9.
"Pretty in Pink" and "She's All That"
They're new at the Central Cinema in Seattle. All shows $6-$8.
"About Time"
It plays at the Tin Theater in Burien this week. All shows $8.
"47 Ronin"
It's new at the East Valley 13 in Renton. Also there: "Grudge Match," "Walking with Dinosaurs," "Anchorman 2: The Legend Continues," "The Best Man Holiday," "Thor: The Dark World," "Ender's Game," "Free Birds," "Escape Plan," "Cloudy with a Chance of Meatballs 2," "The Butler" and "Despicable Me 2" ($3.50).
"Devil's Due" and "47 Ronin 3D"
They're new at the Gateway in Federal Way.
Also there: "Thor: The Dark World 3D," "Paranormal Activity: The Marked Ones," "Grudge Match," "Anchorman 2: The Legend Continues," "A Madea Christmas," "Delivery Man," "Walking with Dinosaurs 3D," "Ender's Game" and "Cloudy with a Chance of Meatballs 2 3D" ($2, all seats on Tuesdays $1).


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40, Albuquerque, NMHi! Faith and family are very important to me. I'm passionate about learning, the outdoors and relating to people in all walks of life. I am very active and love to compete ...
23, Clovis, NMHi, my name is Chris. There isn't too much exciting things about me, I go home and work. I attend mass weekly. I am a eucharistic minister to the homebound and have a hobby/si...
25, Portales, NMHello! I'm Howard. My family and some of my friends call me by my middle name, Brad, but work friends call me Howard. I am a pilot in the Air Force in New Mexico currently liv...
74, Albuquerque, NMI have been single a long time and am kinda set in my ways, but I am willing to work on it, I think. My three young adult children are very close to me and have made me extrem...
45, Santa Cruz, NMI like to joke around and like a good laugh, but also can enjoy a good and serious conversation. I am a family man, and enjoy hanging out with my nieces and nephews. I enjoy t...
34, Los Alamos, NMI am particularly passionate about engineering research and education. I have spent many years learning to be a fabricator as well. There is nothing made by human hands that...
22, Grants, NMI have my degree in Mass Communications & Journalism from UNM. I haven't dated in a while and I feel it is time to find a Catholic girl. I am originally from Grants and attend...
59, Las Cruces, NMSince I've retired I enjoy working out on the treadmill, bike riding, going to see movies, playing pool when I can, working on my yard, going to church, camping and hiking. I ...
30, Dulce, NMI'm a single man who loves & serves God and would like the joy and responsibility of being a husband and a father someday. In my spare time I enjoy reading, exercise, cooking,...
30, Albuquerque, NMHey! Let's see... I was raised in Albuquerque. Left after high school for college and graduate school. I've finally returned after schooling, ready to see what God and life ha...
41, Santa Fe, NMI am a nice and hardworking person with good and traditional values. I am also family-oriented and I am proud of my heritage. I enjoy watching football, reading, painting and ...
54, Santa Fe, NMI am in the process of relocating from South Florida (Coral Springs) via New York to Santa Fe, NM...Just myself and my dog (a Husky named Tasha). Moved here to start a new cha...
Catholic Dating By Major City:
- Albuquerque,
- Santa Fe,
- Las Cruces,
- Rio Rancho,
- Farmington,
- Los Lunas,
- Espanola,
- Alamogordo,
- Hobbs,
- Las Vegas,
- Clovis,
- Silver City,
- Carlsbad,
- Gallup,
- Roswell,
- Los Alamos,
- Aztec,
- Bloomfield,
- Portales,
- Belen


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8 year old azteca gelding. 14.3 Rides fantastic. Rides trail, street, and arena. Rides in the water. Has been to rodeos and works cows. Ties trailers,…$3,900
Motown's Specialist, TWHBEA number-21000280 born may 10, 2010. Black with both white hind fetlocks having five world champions in his history. He is a…$6,000
Thunder is one of the sweetest horses on the farm! He is jet black and gorgeous! He has been used to sort and pen cattle, and all aspects of ranch work…$10,000
Filigree "Filly" is a wonderful and beautiful Oldenburg mare registered under The Oldenburg Horse Breeders Society. She is 15 years old, stands at 16.1h…$6,500
Cole On site lease only no feed leases$150
NEW! "Valentine" TB gelding Here's a super been there done that school horse. At 16.1 hands and 12 years young, he can clear just about anything. His…$6,500
Great trail horse. 15.3 hands. As long as I've had her she never bucked or tried to bite. Shes very gentle and would make a pretty pasture ornament. I…$4,000
Lovely six year old gelding . Easy to ride. Good basic dressage including lateral work. Good over fences. Suitable for amateur. Hacks alone or in company…$1,000


text:
Redevelopment projects planned for Port Washington
A pair of redevelopment projects proposed for downtown Port Washington are to be reviewed by the city's Plan Commission on Thursday.
In the 100 block of N. Franklin St., Renew Port Holdings LLC, led by Gertjan van den Broek, is proposing a mixed-use project with first floor commercial space and 18 apartments on the upper three floors.
It will be a combination of new construction and renovated space, said Randy Tetzlaff, city planning and development director.
Also, Franklin Street Holdings LLC, led by Dan Ewig, is renovating the Boerner Mercantile Building, 211 N. Franklin St., into first floor retail space and two floors of offices.
That 21,000-square-foot development should be completed by the end of the second quarter of 2013, Ewig said. He plans to make tenant announcements during the first quarter.
- North side wellness development gets additional funds
- Former east side church razed to create large development site
- Town of Waukesha indoor sports complex wins approvals
- Renaissance Book Shop to be dismantled
- Video: New east side apartments use solar, geothermal to go green
- Laacke & Joys conversion project might get $1 million cleanup loan
- Ruby Isle Shopping Center sold to Piggly Wiggly affiliate
- Company buys, renovates Burlington industrial building
- New industrial facility planned for Saukville
- Warehouse being razed to create Bay View development site
Six start-ups to pitch at Water Summit in June
Casino magnate Wynn envisions water park in the desert
Modine Manufacturing reports quarterly profit, reversing a loss
LGO Group companies in Franklin file for receivership
Unemployment rates dip in Wisconsin metro areas
CEO pay climbs again, even as their stock prices don't
Bank of Montreal is cutting 4% of workforce
American Family Insurance inks baseball great Jeter as 'brand ambassador'
Boston Store to hold open house to show off renovated space in downtown store
Memorial Day weekend kicks off projected record summer of travel
Bayshore Town Center plans include razing former Sears store and building apartments
L.L.Bean plans first Wisconsin store at The Corners in Brookfield
Muskego mixed-use project, including Sendik's, wins key approval
Schaefer to resign as CEO of Citizens Community Federal Bank
Commercial Real Estate News
Muskego mixed-use project, including Sendik's, wins key approval
A plan to develop apartments and retail space, including a future Sendik's Food Market, in Muskego is taking a big step forward with its latest city approval.
The Common Council voted 6-1 at its Tuesday night meeting to rezone the site for Parkland Towne Center.
Ener-Con Cos. and Devo Properties LLC want to develop the $33 million mixed-use project on the 10.8-acre former Parkland Mall property.
Check the Milwaukee Assessor's Office website, which includes tools to look up property assessments.
Find property assessments for other communities throughout the state at AssessorData.org.
The Milwaukee Department of City Development website includes information on the city Plan Commission and Redevelopment Authority.
The Commercial Association of Realtors Wisconsin offers information on commercial realtors and real estate.
The Milwaukee chapter of the Institute of Real Estate Management serves the needs of real estate management professionals
The Wisconsin chapter of the NAIOP Commercial Real Estate Development Association aims to serve developers and owners of commercial real estate.
The Land and Space blog was recognized by the Society of American Business Editors and Writers in the blog category for dailies with circulation between 200,000 to 500,000.
The judges said, "Daykin's aggressive reporting and accessible, explanatory writing make him a must-read for his tight-knit and highly engaged audience."


text:
Follow along with step-by-step beading projects and share your designs with beaders around the world—it's quick & easy!
- "Red Creek Jasper": on
"Skip my question about your horn source; I just found the answer in another post.…" read »
- "Exotic Safari": on
"Gorgeous horn!…" read »
- "Red Creek Jasper": on
"Stunning and so unique! Fave! Would you mind sharing where you purchased the fog horn? Remember…" read »
- "Cloisonné Anyone?": on
"Your cord is perfect for the pendant, this is so delicate and lovely!…" read »
- "Update": on
"I was going to ditto CAS, but I'll ditto everyone! Each pair just gets better,…" read »
- "Blues Flea Market": on
"Cooper is adorable! Love both your bracelets. The unusual materials used creatively result in unique pieces…" read »
- "Update": on
"Thanks for the update. Glad surgery went well, now for the heavy lifting. The retina thing…" read »
- "Purple Squared is Hip": on
"Beautiful and Prince would be jealous of your purple design. PURPLE FOREVER!…" read »
- "Cranberry Heart set": on
"Just beautiful! Love your designs and workmanship! Multi-talented and a great friend!…" read »
- "Fini!": on
"Love the fluorite. I have some fluorite beads form a long time ago. Love what you…" read »
- "Two More Fini!": on
"Love, love the design and your skills!…" read »
- "Sand & Sea": on
"Your designs again blow me away. The fog horns are beautiful.…" read »
- "Sticks & Stones": on
"Ditto to all of the above comments! Your designs take my breath away!…" read »
- "Exotic Safari": on
"I love the necklace and the pendant again is so unique. The picture is great with…" read »
- "Cloisonné Anyone?": on
"Love the cloisonné. Beautiful kumihimo work! Love the design!…" read »
- "Blues Flea Market": on
"Andy, thank you for downloading your creative designs for us to experience. Ditto to all above.…" read »
- "Azure Atmosphere": on
"Andy, first off I would love anything Cooper loves! This bracelet is very much a celebration…" read »
- "LOVIN' NUETRAL": on
"Yeah, thank you everyone. We hated to buy a new camera but felt over all it…" read »
- "Azure Atmosphere": on
"Cooper loves BRIGHT COLORS for summer!! …" read »
- "Blues Flea Market": on
"Cooper loves RED! …" read »
- "Azure Atmosphere": on
"Such sweet feedback! Thank you! This is Stretch Magic 1mm cord. I find it's thick…" read »
- "Azure Atmosphere": on
"I love this!!! Is that cap on the tassel hand crocheted? Your talent really…" read »
- "Blues Flea Market": on
"Cooper is awesome as the gorgeous bracelet! I love the color combination and that shrinky…" read »
- "Update": on
"All are absolutely gorgeous and unique! I love the pair with the purple flowers and…" read »
- "Update": on
"I bet that top pair just lightly whispers against your cheek. All are marvelous!…" read »
- "Azure Atmosphere": on
"I Love this! Does it roll on or does it stretch? I don't see a clasp.…" read »
- "Azure Atmosphere": on
"Andy, this another ooooohhhhh ... aaaahhhhh bracelet! I love the bead mix, and again your…" read »
- "Blues Flea Market": on
"Awwwwwwww! Isn't he (it is a he, right?) totally and utterly adorable!! Just…" read »
- "Blues Flea Market": on
"My dog Cooper is my greatest inspiration! …" read »
- "Update": on
"Holy moly Asia! These are UTTERLY FABULOUS, MEGA OOOOHHHHHH ... AAAAAAHHHHHH INDUCINGLY GORGEOUS!!!!!! There…" read »
- "Honey Do List May 2016": on
"This is so beautiful,fantastic balance, love this colour combination must be one of my favorite…" read »
- "Today's lesson": on
"Love this Lynda, I had been practicing with beads and solder myself, but I only have…" read »
- "Medieval Teal Necklace": on
"Great colours and eclectic combination, have the same beads in my stash, need to use them…" read »
- "Denim Zola": on
"Love Zola elements and you made a wonderful piece with it …" read »
- "Purple Squared is Hip": on
"Great idea, delish colours …" read »
- "Bronzed Rose": on
"Beautiful work …" read »
About this design:
This just evolved after I purchased the purple mother of pearl beads. I had an odd silver tube bead laying around and it just came together. This one sold quickly. I keep saying I'm going to make another for me, but haven't yet.
Components:Purple Mother of pearl long ovals, dark purple glass beads, sterling bead, sterling wire, one peacock pearl, sterling clasp
Read the comments (or add your own)
Well, how cool is this??!! You are right, it does go together in a perfect way!!
Wow, I agree with Elaine this is way cool!
Just gorgeous! I'm not a fan of purple, but your design is stunning, and as Elaine & Angie say "way cool"!
I agree! This is WAY cool!
So pretty. I love the shells and silver bits and I really love purple.
Really, really love this!!! I would wear this any day!!
Celestial Designs I love this. You are so talented.
Fabulous design and colors!
Guess I am going to follow you, too, Chicky LE! This is beautiful, so glad you found it! And it's nice to be on your trail again!1
I think I found an older creation on one of my little side trips Lynn Eileen and Plucky Chick helping spread congratulations see sometimes second time around brings good things too. Elaine
commented on this June 24, 2009
I'm glad you found this, Faith!
Me too. I love the focal beads and the purple pearls and wire work. OMG Just drop dead gorgeous.
Add your thoughts!
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Nevada Union softball's Sarah Lundmark helped the Lady Miners to an 11-10 victory over Yuba City in extra innings Monday. The sophomore shortstop and part-time pitcher went 3-for-3 from the plate with a home run, a double, a single and four RBIs in the win.
Back to: NewsBriefs
March 9, 2013
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Suburban Propane's Player of the Week: Sarah Lundmark
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- Nevada County man dies in La Barr Meadows Road crash
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- Penn Valley committee weighs school closure amid deficit spending, declining enrollment
- Grass Valley group brings all ages together through music at 'the Bomb Shelter'
- Grass Valley man cleared after drug raid arrest


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Relevant offers
Travel Troubles
Residents of Bowen in north Queensland, Australia awoke to a shock: a 10-metre tall tourist attraction known as the 'Big Mango' had mysteriously disappeared.
Police suspect pranksters for the overnight heist although we wouldn't rule out peckish UFO pilots either. Whatever the cause, there's now one less 'big thing' to take photos of in Australia. Thankfully, there are still plenty of over-sized tourist attractions to gawp at should the mood strike you.
Bowen's Big Mango is a 10-metre-high fibreglass structure that requires heavy machinery to move. It's sudden disappearance has baffled local authorities and residents alike.
Chairman of Tourism Bowen Paul McLaughlin told ABC News that the Mango was not scheduled for maintenance.
"I'm sure the public will help us find it but at this stage we are just on the early stages of looking at [security] footage," McLaughlin said.
ABC reports that it could be a hoax, but until the Big Mango is rebuilt or uncovered, you're going to have to settle for one of the other Big Things that currently dot the Australian landscape. From the Big Lobster in Kingston SA to the Big Beer Can in Cobar NSW. See 'em before they disappear!
- Lifehacker.com.au
Sponsored links
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World's most isolated destinations
Ask an expert: The best time to book your flights
Shooting of gorilla in US zoo sparks outrage
Richie McCaw digs for business experience at quarry
Short-staffed KFC workers under pressure but it's 'hard to get a job there'
Lobby group Family First blames unmarried couples for child poverty
Zuri the giraffe to dodge bridges, wires and tasty trees on her road trip to Wellington
Johnny Depp's exes, daughter defend him amid allegations of domestic violence
The Bachelor: Jordan's dating days are over
Ardie Savea's 'heart of a lion' sees him achieve his All Blacks dream
Judge orders release of documents in Trump University class-action lawsuit
Lewis Hamilton wins thrilling Monaco GP ahead of Daniel Ricciardo
Shooting of gorilla in US zoo sparks outrage
Mahe Drysdale scores big win at World Cup as Kiwis lead medal tally in Lucerne
Scott Dixon struggling for pace at Indianapolis 500
Mexican football star Alan Pulido kidnapped in border state
Kane Williamson carries the drinks as David Warner blasts Sunrisers Hyderabad to IPL title
Short-staffed KFC workers under pressure but it's 'hard to get a job there'
Richie McCaw digs for business experience at quarry
The Bachelor: Jordan's dating days are over
10 habits of people who always have a clean home
Cincinnati Zoo kills gorilla to protect small child in enclosure
Man who tried to cook squirrel causes $3m damage to apartment complex
Booze ban for Trentham Racecourse after minors were served alcohol at Wellington Cup Day
Ardie Savea's 'heart of a lion' sees him achieve his All Blacks dream
Johnny Depp's exes, daughter defend him amid allegations of domestic violence
Mahe Drysdale scores big win at World Cup as Kiwis lead medal tally in Lucerne


text:
Alfred Hitchcock Presents TV Show Watchlist
Season 1, Episode 24 Deadly Honeymoon
First Aired: April 13, 1986
A woman learns that her new husband (David Dukes) has debts and two deceased wives, whose lives were heavily insured. Wells: Alan Fudge. Phil: Nicolas Coster. Chief Resident: Helen Powell Nemir.
Guest Cast
Helen Powell Nemir Helen Powell Nemir Chief Resident
Alan Fudge Alan Fudge Wells
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- Rating: None
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Mark Strand's Poetry Moved Easily From Common To Sublime
Poet laureate Mark Strand has died at age 80. He spurned conventional form and wrote spare and haunting prose, which won him the Pulitzer Prize for Poetry in 1999.
Mark Strand, a former U.S. poet laureate, passed away yesterday at the age of 80. His work was spare and haunting, devoid of embellishment. His deceptively simple poems explored the strangeness and alienation that happens in a life. In 1999, Strand was awarded the Pulitzer Prize for his collection "Blizzard Of One." One review described the poems as moving with, quote, unerring ease between the commonplace and the sublime. A few years ago, Strand reimagined himself as a Spanish poet reaching his final days. Here he is reading that work.
MARK STRAND: (Reading) Black fly, black fly, why have you come? Is it my shirt? My new white shirt with buttons of bone? Is it my suit? My dark blue suit? Is it because I lie here alone, under a willow, cold as stone? Black fly, black fly, how good you are to come to me now. How good you are to visit me here. Black fly, black fly, to wish me goodbye.
MARTIN: Even though he often used the past as a theme, Strand looked toward what was to come. On this Sunday morning, we remember him with his own words. The future is always beginning now. You're listening to NPR News.
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Isobutanol-Blended Gasoline Offers Alternative Fuel Option for Boaters
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PIC: Katrina Kaif looking hot in a bikini01 Off late, Katrina Kaif has been making a lot of heads turn with her slim and trim avatar after her alleged break-up with Ranbir Kapoor. She gave another proof of her transformed body when she posed for a magazine cover in a bikini. In the ... Times of India, 2 weeks ago
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