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HD VIDEO & WEB DESIGN by ATGNAT - A Houston Video Production and Website Design Company
Web Marketing by Ceatus Media Group
International EyeCare Laser & Lifestyle Center is now even more convenient for Aggies!
Great News! Now Dr. Charlie Moore and his staff from International EyeCare Laser & Lifestyle Center in Houston are evaluating Aggies and their fans at their new College Station LASIK and cataract surgery office at 1101 University Drive East, Suite 104.
Even if you have been told that you are not a candidate for the LASIK procedure, the doctors at International EyeCare Laser & Lifestyle Center can help.
Schedule your Free Evaluation online today or call us at (979) 260-2500 and we'll be seeing you at our new office in College Station soon. Now we're making it even easier for Aggies to learn about LASIK.
It's easy - Just sign up for a free, no obligation evaluation with International EyeCare Laser & Lifestyle Center today and let us determine if you are a candidate for the Lasik procedure.
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What Aggies are saying about International EyeCare Laser & Lifestyle Center
Finding the right surgeon and the right facility for your laser eye surgery or cataract surgery can take some thought. We understand that your eyes are very important to you, and you don't want just anyone performing your LASIK surgery procedure. Patients come from all over the United States and even from around the world to have their laser eye surgery performed at International EyeCare Laser & Lifestyle Center headed by Charles R. Moore, M.D., F.I.C.S. Out of all the options you have to receive LASIK or cataract surgery in College Station, or anywhere in the world for that matter, you will be challenged to find doctors more qualified than Dr. Moore and his highly trained medical team who have performed more than 80,000 procedures.
One of the best ways to find out who the best laser eye surgeons in College Station are is to see whom other surgeons and physicians trust their eyes to when they chose to have LASIK. We are proud that more than 100 surgeons, physicians and dentists—including other ophthalmologists — have chosen International EyeCare Laser & Lifestyle Center for their LASIK procedures. This is our strongest testimonial and one of the major reasons you need to find out more about why International EyeCare Laser & Lifestyle Center should be your choice for your laser eye surgery.
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On Facebook the team wrote "LANDED LANDED LANDED! Mr. Michael Del Zotto is here! Landed at 10.20 pm. It is sad… because he missed the morning workout;-) WELCOME TO RAPPERSWIL-JONA MICHAEL!"
Picture: Michael Del Zotto In His Lakers Jersey
You can tell Big Mo does not want to talk about the Jets (who would?).....
Poor guy....It must be hard playing for an owner and a GM who send you to battle with an inferior army behind you, and then claim that they want to win....
This is a 1st round defense with no CB's. It's a mid round offense with some over the hill veterans. The offense can't score points, and seems to lead the league in turnovers and penalties just about every year....
Why would Wilkerson even want to remain a Jet? They are going to have to over pay to keep him
heres my prediction for sunday: decker changes uniforms at half time.
not even going to watch that. too much koolaid coming out of florham.
"Rex always have our backs and we always have his back" - MoWilk
Kinda gives you that secure, warm fuzzy feeling, don't it???

subset: commoncrawl


text: Excellent location, great pool, host Fotis is very friendly, food was good and cheap. As a base it is perfect. Apartment was big and the kitchen area was well stocked with a good selection of utilities including a good sized fridge freezer. Clean throughout. Couldn't fault the place. Highly recommended. Jon & Ali.


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Helpful Relief at the Gas Pump
Some lucky drivers heading out of town for Memorial Day weekend got a surprise at a local Mobile gas station in Newbury Park Friday afternoon. Helpful Honda crews were on hand to lessen the burden of increased fuel costs by treating motorists to complimentary tanks of gas, as part of the ongoing Southern California Honda Helpful campaign.
"I've heard of the Helpful Honda people before, but I've never actually seen them," said a father of two young girls driving to visit family in Arizona. "Times are hard for a lot of people these days, so this makes a real difference. Every little bit helps."
Now in its third year, the Honda Helpful campaign and affiliated teams of 'Guys & Girls in Blue' are standing by their promise to be helpful by making visits, often unexpectedly, to busy locations and providing assistance where needed. Last month, they were at markets carrying groceries for shoppers; distributing eco-friendly tote bags to encourage the reduction of plastic bags; and educating residents of the proposed California State Assembly bill (a $0.25 fee on the use of plastic bags at large grocery and convenient stores throughout the state).
"All of the people we came into contact with today were surprised and very thankful to receive the support," said Honda Helpful's Andrea Trembow. "We'll be out and about all summer, so make sure to look for the helpful people in the blue shirts."
Subscribe to the Ventura County Star
Need Help? Call us at 1-877-710-6182.
Monday-Friday: 6am-3pm / Saturday: 6:30am-10:30am / Sunday: 7am-11am


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During one three-day weekend each January, the Interior Design Show shapes the industry for the year to come – in North America and beyond. The 18th edition of Canada's design fair celebrates leading brands, innovative speakers and rising local talents. Look for spotlights on Canadian-made products and small-batch designers, as well as Nichetto Studio's never-before-seen exploration of urban dwellings and International Guest of Honour Wanda Jelmini's Missoni retrospective. Welcome to the Interior Design Show. We hope you enjoy exploring the people, products and places that make the design world so exciting and inspiring.
In January 1999, the first Interior Design Show opened its doors to an enthusiastic design community, media world and consumer market. An important milestone for Canada's design scene, the first show brought together 25,000 visitors, who came to see Wallpaper* magazine founder Tyler Brulé, Droog's Gijs Bakker and furniture designer Holly Hunt. After 15 years, the Interior Design Show has become one of the most successful recurring design events in Canadian history and over the years has inspired over 660,000 visitors. Attendance has almost double since the show's inception, and international designers and architects travel from around the world to stand on the IDS main stage. The Interior Design Show has established itself as the breeding ground for design creativity, innovation and inspiration, bringing together hundreds of exhibitors and thousands of visitors each year.
In 2012, the Interior Design Show was purchased by Informa, the largest publically-owned organizer of exhibitions, expositions and training events in the world. With 150 offices in 40 countries, Informa brings together over a million professionals each year. The newly formed Informa Canada manages over 53 tradeshows, consumer shows and conferences around the country, serving the construction, real estate, craft, art and design markets.


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kettl-a, I think you are right. I am long, too. I can't say that I am happy about my investment decision to go long, but here, right now... I'm long hoping things improve for us shareholders. I agree with your posts... even though you are labeled a bull and I a crazy basher. I think we pretty much agree on what needs to happen and the consequences if it doesn't.


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Page 1
Oleanolic acid and related derivatives as medicinally important
1PCSIR Laboratories Complex, Pharmaceutical Research Center, Karachi 75280, Pakistan, and2Department of Chemistry,
The University of Winnipeg, 515 Portage Avenue, Winnipeg, MB, Canada R3B 2E9
(Received 28 April 2007; accepted 29 July 2007)
Oleanolic acid has been isolated from chloroform extract of Olea ferruginea Royle after removal of organic bases and free acids.
The literature survey revealed it to be biologically very important. In this review the biological significance of oleanolic acid
and its derivatives has been discussed. The aim of this review is to update current knowledge on oleanolic acid and its natural
and semisynthetic analogs, focussing on its cytotoxic, antitumer, antioxidant, anti-inflamatory, anti-HIV, acetyl
cholinesterase, alpha-glucosidase, antimicrobial, hepatoprotective, anti-inflammatory, antipruritic, spasmolytic activity,
anti-angiogenic, antiallergic, antiviral and immunomodulatory activities. We present in this review, for the first time, a
compilation of the most relevant scientific papers and technical reports of the chemical, pre-clinical and clinical research on
the properties of oleanolic acid and its derivatives.
Keywords: Oleanolic acid, biological significance, olea ferruginea
Oleanolic acid (1) along with other triterpenoidal
compounds like, ursolic acid (2, Scheme–1), olea-
nolic acid glycosides and few sugers were isolated from
Olea ferruginea [1] and also from R. stricta growing in
Kashmir [2]. A group of scientists from Japan isolated
a hypoglycaemic component, elatoside E, and elato-
side Falong with oleanolic acid and its glycosides from
the root cortex of Aralia elata Seem. (Araliaceae)
growing in Japan [3]. Chemical investigation of
Eugenia jumbolana flowers by scientists also revealed
the presence of oleanolic acid [4]. Isolation of
oleanolic acid from various plants by different workers
has been known. The plants were Beta vulgaris L.
(Suger Beet,Chenopodiaceae) [5], Kochiae fructus [6],
Kochia scoparia Schrad, Momordica cochinchinensis
Spreng.) [7], Tiarella polyphylla [8], Clerodendranthus
spicatus [9], Perilla frutescens [10], Glechoma hederaceae
[11], Olea europaea [12,13], Couepia polyandra [14],
Liquidambar formosana [15], Pistacia terebinthus
galls[16], Rosmarinus officinalis L. [17], Crataegus
pinnatifida Bunge [18], Luffa cylindricall [19], Rosa
woodsii, (leaves), Prosopis glandulosa (leaves and twigs),
Phoradendron juniperinum (whole plant), Syzygium
claviflorum (leaves), Hyptis capitata (whole plant),
Ternstromia gymnanthera (aerial part) [20], Plantago
major [21] and Ludwigia octovalvis [22]. A number of
oleanolic acid derivatives have been prepared.
Oleanolic acid derivatives (4-14) showed anti-HIV
activity. 3-O-fatty acid ester derivatives (22-27)
showed antifeedant activity. Semi synthetic oleanolic
acid derivatives (2-7) showed gastro protective and
ulcer-healing activity. Oleanolic acid glycosides (41-
45) showed gastrointestinal transit accelerating
activity. Three oleanane type triterpene (15-17)
showed significant cytotoxicity against two human
tumor cell lines. These derivatives have attracted
considerable interest due to there biological activity.
ISSN 1475-6366 print/ISSN 1475-6374 online q 2008 Informa UK Ltd.
Correspondence: N. Sultana, PCSIR Laboratories Complex, Pharmaceutical Research Center, Karachi 75280, Pakistan. Tel: 92 21 8141832
35. Fax: 92 21 8141847. E-mail: email@example.com
Journal of Enzyme Inhibition and Medicinal Chemistry, December 2008; 23(6): 739–756
Journal of Enzyme Inhibition and Medicinal Chemistry Downloaded from informahealthcare.com by Universitaetsbibliothek Duisburg-Essen on 05/20/14
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Page 2
Individual presentations on various aspects of olea-
nolic acid and its derivatives have been appeared as
articles in journals [8–16] but only few publications in
a compiled form have appeared on oleanolic acid and
its derivatives.
Biological and pharmacological significance
of oleanolic acid:
Oleanolic acid is a triterpenoid which is quite common
in nature in the form either of free acid or in
triterpenoid saponin glycosides found in food,
medicinal herbs and various other plants in free form
or bound to glycosides and is distributed wildly in
plants all over the world. In recent years, it was found
that it had marked biological and pharmacological
Oleanane triterpenoids with inhibitory activity against
NFAT transcription factor from Liquidambar formosana
In a search for inhibitory components from natural
products against NFAT transcription factor, this study
investigated the ethyl acetate extract of the fruits of
Liquidambar formosana. Four oleanane triterpenoids
were isolated and identified to be liquidambaric acid,
oleanolic acid, 3 alpha-acetoxy-25-hydroxy-olean-12-
en-28-oic acid and lantanolic acid. Of these
compounds, 3 alpha-acetoxy-25-hydroxy-olean-12-
en-28-oic acid (IC50: 4.63 microM) and lantanolic
acid (IC50: 12.62microM) exhibited strong inhibitory
activity against the NFAT transcription factor [15].
Oleanolic acid as a trypanocidal constituent in Rosemary
The MeOH extract of the leaves of Rosemary
(Rosmarinus officinalis L.) completely inhibited the
motility of cultured epimastigotes of Trypanosoma
cruzi at the concentration of 2mg/mL after 2hours of
incubation. Activity-guided fractionation of the
MeOH extract has resulted in the isolation of three
triterpene acids, betulinic, oleanolic and ursolic acids.
Ursolic acid stopped the movement of all T. cruzi
epimastigotes at the minimum concentration (MC
(100) of 40micro g/mL (88micro M) after 48hours of
incubation. Oleanolic acid was less active (MC (100):
250micro g/mL, 550micro M) and betulinic acid was
practically inactive [17].
Two triterpenoid compounds, ursolic acid and
uvaol, were isolated from Crataegus pinnatifida Bunge
leaves. Ursolic acid inhibits chitin synthase II from
S. cerevisiae with an IC50value of 0.84microgram/mL
and the inhibition appears to be selective for chitin
synthase II, whereas uvaol has no inhibitory activity
up to 280micrograms/mL. Oleanolic acid, alpha-
hederin hydrate and betulic acid inhibited the chitin
synthase II activity under the same conditions with an
IC50of 5.6, 64.3 and 98.7micrograms/mL, respect-
ively [18].
Oleanolic acid, isolated from Luffa cylindrica,
inhibits the in-vitro immunohaemolysis of antibody-
coated sheep erythrocytes by guinea-pig serum. In
further experiments this reduced immunohaemolysis
was found to be due to inhibition of the C3-convertase
of the classical complement pathway. The threshold
concentration for inhibition of C3-convertase was
100micrograms mL21. However, higher concen-
trations of oleanolic acid showed constant inhibitory
Scheme 1.
N. Sultana & A. Ata
Journal of Enzyme Inhibition and Medicinal Chemistry Downloaded from informahealthcare.com by Universitaetsbibliothek Duisburg-Essen on 05/20/14
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Page 3
effects on immunohaemolysis. Oleanolic acid also
exhibited weak inhibitory effects on individual
components of the complement system [19].
A hexane extract of Plantago major was investigated
by bioactivity-directed fractionation, using an in vitro
cyclooxygenase-2 catalyzed prostaglandin biosyn-
thesis inhibition assay, and resulted in the isolation
of ursolic acid. This triterpenoid showed a significant
cyclooxygenase -2 inhibitory effect, directly on the
enzyme activity, with an IC50value of 130microM
and a cyclooxygenase-2/ cyclooxygenase-1 selectivity
ratio of 0.6. The structural isomer oleanolic acid was
found to be less active than ursolic acid, with an IC50
value of 295microM, but showed a similar selectivity
ratio (0.8). Furthermore, no significant inhibition on
cyclooxygenase -2 or cyclooxygenase-1 was observed
by the triterpenoid, 18 beta-glycyrrhetinic acid (3).
The direct inhibitory effect of oleanolic acid and
ursolic acid on cyclooxygenase-2 catalyzed prosta-
glandin biosynthesis increased with preincubation,
indicating a time-dependent inhibition, while the
effect on cyclooxygenase-1 was found to be indepen-
dent of preincubation time [20].
The antifertility activity of oleanolic acid, isolated
from the flowers of Eugenia jambolana, was evaluated
in male albino rats. The administration of the
compound for 60 days decreased the fertilizing
capacityof the animalswithout anysignificant changes
in body weight or reproductive organ weights. The
compound produced arrest of spermatogenesis but
did not cause any abnormality to spermatogenic cells,
Leydig interstitial cells and Sertoli cells. Oleanolic
acid may prove to be a promising antifertility agent
devoid of undesirable side effects [4].
Hepatoprotective effects of momordin Ic and
oleanolic acid obtained from Kochiae Fructus, the
fruit of a traditional Oriental medicinal plant, were
evaluated against carbon tetrachloride (CCl4)-
induced liver damage in rats. Male Sprague-Dawley
rats were divided into four groups: control, CCl4-
treated, CCl4 plus momordin Ic-treated (MMDIc-
CCl4), and CCl4plus oleanolic acid-treated (OAA-
CCl4). Momordin Ic (30mg/kg of body weight) and
oleanolic acid (30mg/kg of body weight) were orally
administered once a day for 14 days. A mixture of
0.2mL/100g of body weight of CCl4in olive oil (1:1,
vol/vol) was injected 30minutes after the final
administration of momordin Ic and oleanolic acid.
The momordin Ic and oleanolic acid pretreatments
resulted in significantly lower serum transaminase,
lactic dehydrogenase, and gamma-glutamyltransferase
levels in the CCl4-treated rats. The CCl4-treated rats
had significantly lower activities of glutathione,
glutathione reductase, glutathione S-transferase,
superoxide dismutase, catalase, and glutathione
peroxidase. However, pretreatment with momordin
Ic and oleanolic acid reduced the effect of CCl4and
helped maintain levels of the enzymes. Pretreatment
with momordin Ic and oleanolic acid resulted in
significantly lower production of aminopyrine N-
demethylase and aniline hydroxylase in the CCl4-
treated rats. Pretreatment with momordin Ic resulted
in lower catalase and aminopyrine N-demethylase
activity induction by CCl4, towards normalization.
Momordin Ic and oleanolic acid obtained from
Kochiae Fructus appear to contribute to alleviating
the adverse effects of CCl4treatment by enhancing the
hepatic antioxidant defense system [6].
Chikusetsusaponin IV and V, whose genin is
oleanolic acid, exhibited weak hemolytic activities.
Removal of glucose residue at position 29 of
chikusetsusaponin V by partial hydrolysis increased
the activity more than 30-fold. Methylation of the
carboxyl group at position 28 increased the activity
furthermore by about 10-fold, showing HD50value of
3.77microM. On the other hand, removal of the sugar
chain at position 3 of chickusetsusaponin V by partial
hydrolysis completely lost the activity. These facts
suggest that the sugar chain at position 3 of oleanolic
acid is essential but that at position 29 is pernicious for
the activity. The cytolytic agents, whose target has
been regarded as membrane cholesterol, were inacti-
vated not only by cholesterol but also by sapogenins
such as oleanolic acid, gitogenin and hederagenin.
Among saponins tested, akebia saponin B and C were
inactivated by cholesterol, but not by the genins,
probably because their affinities for the genins are too
low to form complexes [23].
Oleanolic acid and ursolic acid were examined for
anti-angiogenic activities by using the chick embryo
chorioallantoic membrane assay. The presence of
ursolic acid or oleanolic acid inhibited angiogenesis in
a dose-dependent manner; the doses required for half-
maximal inhibition (ID50) were 5 micrograms and
40microgramsper chorioallantoic
respectively. Ursolic acid was a more potent angio-
genic inhibitor than oleanolic acid. It was also tested
for inhibitory effect on the proliferation of bovine
aortic endothelial cell. They effectively inhibited the
proliferation of bovine aortic endothelial cell in a
concentration-dependent manner. The IC50values of
anti-proliferative effects were determined to be
5microM for ursolic acid and 20microM for oleanolic
acid. Based on these results, it was speculated that the
inhibitory effects on bovine aortic endothelial cell
proliferation of ursolic acid and oleanolic acid might
be important for anti-angiogenesis [24].
In vitro anti-HIVactivity of oleanolic acid and its
derivatives on infected human mononuclear cells
Oleanolic acid was identified as an anti-HIV principle.
It inhibited HIV-1 replication in acutely infected H9
cells with an EC50 value of 1.7microg/mL, and
inhibited H9 cell growth with an IC50 value of
21.8microg/mL [therapeutic index (T. I.) 12.8].
Biological activity of oleanolic acid derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry Downloaded from informahealthcare.com by Universitaetsbibliothek Duisburg-Essen on 05/20/14
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Page 4
Pomolic acid, isolated from R. woodsii and H. capitata,
was also identified as an anti-HIV agent (EC50
1.4microg/mL, T. I. 16.6). Although ursolic acid did
show anti-HIV activity (EC502.0microg/mL), it was
slightly toxic (IC506.5microg/mL, T. I. 3.3). A new
triterpene, 1beta-hydroxy-2-oxopomolic acid was also
isolated from the CHCl3-soluble fraction of R. woodsii,
though it showed no anti-HIVactivity. Based on these
results, the examination of the anti-HIV activity of
oleanolic acid- or pomolic acid-related triterpenes
isolated from several plants were carriedout. In
addition, the derivatives of betulinic acid, isolated
from the leaves of S. claviflorum as an anti-HIV
principle, exhibited extremely potent anti-HIV
activity. Accordingly, derivatives of oleanolic acid (4-
14) showed their anti-HIVactivity (Scheme 22) [21].
Anti-AIDS agents. anti-HIVactivity of oleanolic acid and
structurally related triterpenoids
As seen in previous betulinic acid derivatives,
oleanolic acid 3-O-30, 30-dimethylsuccinate (4)
demonstrated a most potent anti-HIV activity, with
an EC50 value of 0.0005I`g/mL, and showed a greatly
improved T. I. value (22 400), while the lack of any
discernible anti-HIV activity in its isomer (5) was
similar to the corresponding betulinic acid derivative.
Compounds 6, 11, and 12 displayed relatively potent
anti-HIV activity, with EC50 values of 1.5, 1.1, and
1.2I`g/mL, respectively, but were not as potent as 4.
Moreover, the small T. I. values of 11 and 12 (4.1 and
3.9, respectively) suggested that they are slightly toxic.
Oxidation of oleanolic acid (1) with pyridinium
chlorochromate (PCC) yielded a 3-oxo- derivative
(13), which was more toxic against uninfected H9
cells than its parent compound, but inhibited HIV-1
replication, with an improved EC50 value of
0.11I`g/mL. Treatment of 1 with a molar equivalent
of potassium hydroxide furnished the potassium salt of
oleanolic acid (14). Compound 14 exhibited potent
anti-HIV activity, with an EC50 value of 0.5I`g/mL
and a T.I value of 68.6. Such enhanced anti-HIV
activity with the potassium salt (Scheme 2).
Three new oleanane-type triterpenes from Ludwigia
octovalvis with cytotoxic activity against two human
cancer cell lines
Three new oleanane-type triterpenes, (23Z)-coumar-
oylhederagenin (15), (23E)-coumaroylhederagenin
(16) and (3Z)-coumaroylhederagenin (17) (Scheme–
3) together with two known triterpene acids, oleanolic
acid and ursolic acid, have been isolated from the
whole plant of Ludwigia octovalvis, and their structures
have been elucidated by spectroscopic methods.
All three new triterpenes showed significant cytotox-
icity against two human tumor cell lines, namely,
oral epidermoid carcinoma KB and colorectal
carcinoma HT29, and gave IC50values in the range
1.2-3.6microM [22].
Scheme 2.
N. Sultana & A. Ata
Journal of Enzyme Inhibition and Medicinal Chemistry Downloaded from informahealthcare.com by Universitaetsbibliothek Duisburg-Essen on 05/20/14
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Page 5
Oleanolic acid derivatives with different lengths of
3-O-acidic acyl chains were synthesized and evaluated
for their inhibitory activity against HIV-1 protease.
The lengths of the acidic chains were optimized to 6
and 8 carbons. Changing a 3-ester bond to an amide
bond or dimerization of the triterpenes retained their
inhibitory activity against HIV-1 protease. Introduc-
tion of an additional acidic chain to C-28 of oleanolic
acid increased the inhibitory activity appreciably,
though a derivative with onlyoneacidic chain linked at
C-28 also showed potent activity against HIV-1
protease. The inhibitory mechanism was proved
directly by size exclusion chromatography to be
inhibition of dimerization of the enzyme polypeptides.
The ester bonds of the triterpene derivatives were
found to be stable to lipase under mild alkaline
conditions [26].
3-O-acyl-betulinic and oleanolic acids, especially
the 3-O-(30, 30-dimethyl)-succinyl derivatives demon-
strated potent anti-HIVactivity [EC50, 0.00035 and
0.00086microM; therapeutic index (TI) . 20 000
and 22 326, respectively]. Several 3-O-acyl-ursolic
acids were prepared and evaluated for anti-HIV
activity.Ursolic acid
4.4microM) with oleanolic acid (EC50, 3.7microM),
although it was slightly toxic (IC5014.3microM, TI
3.3). 3-O-Diglycoryl-ursolic acid, demonstrated rela-
tively potent anti-HIV activity with an EC50 of
0.31microM and a TI of 155.5. In contrast, 3-O-(30,
30-dimethylsuccinyl)-ursolic acid, which is analogous
to the extremely potent anti-HIV betulinic acid and
was equipotent(EC50
oleanolic acid derivatives, displayed only weak anti-
HIV activity (EC50, 2.1microM, TI 23.6) [41].
The effect of oleanolic acid on the growth of human
immunodeficiency virus-1 (HIV-1) in cultures of
human peripheral mononuclear cells and of mono-
cyte/macrophages (M/M) was studied. Its inhibitory
activity was also evaluated on peripheral mononuclear
cells obtained from HIV-1 infected patients. Results
obtained show that oleanolic acid inhibits the HIV-1
replication in all the cellular systems used (EC50
values: 22.7microM, 24.6microM and 57.4microM
for in vitro infected peripheral mononuclear cells,
naturally infected peripheral mononuclear cells and
M/M, respectively). As regards the mechanism of
action, oleanolic acid inhibits in vitro the HIV-1
protease activity [42].
Oleanolic acid glycosides, saponins, oleanolic
acid synthetic and semi-synthetic derivatives
Antifeedant Activity of Some Pentacyclic Triterpene Acids
and their Fatty Acid Ester Analogues: The 3-O-fatty acid
ester derivatives (22-27) C (12)-C (18) of two
pentacyclic triterpenic acids, ursolic acid and olea-
nolic acid, were synthesized under mild esterification
conditions in excellent yields (80-85%) and screened
for their antifeedant activity, together with the parent
acids, against the agricultural pest tobacco caterpillar
larvae (Spodoptera litura F) in a no-choice laboratory
study. Antifeedants are potential slimming agents.
The Urs-12-ene-28-carboxy-3beta-octadecanoate
(26) and olean-12-ene-28-carboxy-3beta-hexade-
canoate (25) (Scheme– 4) were found to exhibit
exceptionallypotent antifeedant
50microg/cm (2) concentration, even after 48hours
The antipruritic effects of various oleanolic acid
glycosides from natural medicines such as Kochiae
Fructus (the fruit of Kochia scoparia Schrad.) and
Momordicae Radix (the roots of Momordica cochinch-
inensis Spreng.) was examined by using a compound
48/80-induced pruritic model in mice. Oleanolic acid
3-O-monodesmosides showed an antipruritic effect,
while oleanolic acid 3, 28-O-bisdesmosides and their
common sapogenol oleanolic acid lacked the activity.
This evidence indicated that the 3-O-glycoside moiety
and the 28-carboxyl group in oleanolic acid glycosides
were essential for exhibiting the antipruritic effect.
Furthermore, it was found that the 3-O-glucuronides
showed more potent activity than the corresponding
3-O-glucosides [7].
A new triterpenoid acid named eucalyptanoic acid
has been isolated from the fresh uncrushed leaves of
Eucalyptus camaldulensis var. obtusa along with two
known constituents, beta-sitosterol and betulinic acid.
The structure of eucalyptanoic acid has been
established as 3beta-hydroxyolean-9 (11), 12-dien-
28-oic acid. eucalyptanoic acid and its acetyl (28a)
activities at
Scheme 3.
Biological activity of oleanolic acid derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry Downloaded from informahealthcare.com by Universitaetsbibliothek Duisburg-Essen on 05/20/14
For personal use only.


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Remember Me
Before making their own names as the cream of the crop amongst forward-thinking musical acts of the 00's, Kieran "Four Tet" Hebden and Adem Ilhan, along with bandmate Sam Jeffers, were an instrumental British outfit known as Fridge. Together, they forged a bold fusion of the sounds emanating from Chicago's post-rock movement through innovative groups like Tortoise and Gastr del Sol with the skittering electronic rhythms of Aphex Twin and Autechre that remains one of the hidden treasures of the experimental '90s.
However, while you may swear these guys were perpetually connected to some kind of a laptop or drum machine to capture the wholly alien sonic palpitations they created together, many of their compositions were crafted utilizing nothing more than your standard guitar-bass-drums arrangements. And even when they did employ the use of samplers, they did so by such organic means that you couldn't tell what was filched from source material and what was created by their own hands.
Following the trio's surprise reunion album in 2007, The Sun (JamBase review), Fridge look back on their salad days with Early Output 1996-1998 (Temporary Residence), a 21-track collection anthologizing the group's genesis on Output Recordings, a revolutionary electronic-based record label run by Trevor Jackson of the UK dance unit Playgroup. Curated by Hebden, Ilhan and Jeffers themselves, these tracks showcase the band's post-rock leanings more so than their later EPs and LPs, particularly on tracks like the 15-minute "Angelpoised," which sounds like Talk Talk's Laughing Stock crunked out with an 808, or "Orko," a vibe-heavy near-nine-minute jam that comes off like it should owe studio points to John McEntire. It's hard to think this stuff was recorded on cassettes in a crude home studio; it all sounds so great.
Elsewhere, shades of Hebden's evolution as Four Tet can be traced back to tracks like
"Zedex Ay Ti Wan" and "Concert in Your House," while "Helicopter" and "A Swerve and a Spin" offer up a heavy, Slint-like guitar dirge that foreshadows the chaotic freeform of Hebden's recent collaborative work with jazz drummer Steve Reid.
Though most of the material here is from Fridge's first few EPs and their two Output full-lengths, 1997's Ceefax and 1998's Semaphore, Early Output features six previously unreleased tracks: the fuzzy, flowing, ten-minute space jam "Distance" followed by five lo-fi fragments of compositional sketches that barely clock in at three-minutes total.
Longtime fans of Fridge might find this collection a little superfluous if you already own most of what they released on Output. However, for those who got turned onto the genius of Fridge through either Four Tet or Adem, this makes for a great beginner's guide.
JamBase | In The Crisper
Go See Live Music!
To read comments and participate in this story, please visit the Articles forum »


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Finnish Detergent Ad
Finns are rarely excited about anything, but in the 70s they'd flip out over clean clothes. Fun fact: The man in this ad eventually came to be known as Ior Bock, a recently deceased eccentric who taught bizarre practices including autofellatio.
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Citrix Systems Engineering Interview Questions
Interview Experience
Interview Experience
Getting an Interview
Getting an Interview
Interview Difficulty
Interviews for Top Jobs at Citrix Systems
- Software Engineer (30)
- Software Development Engineer (19)
- Technical Support Engineer (17)
- Senior Software Engineer (13)
- Software Test Engineer (7)
- Software Developer (7)
- Engineering (6)
- Intern (6)
- Corporate Sales Representative (6)
- Senior Software Test Engineer (6)
- Software Testing Engineer (5)
- Software Engineer I (5)
- Software Engineer II (5)
- Director (5)
- Staff Software Engineer (4)
- Territory Manager (4)
- Sales (4)
- Consultant (4)
- Technical Relationship Manager (4)
- Technical Analyst (3)
- Marketing (3)
- Senior Manager (3)
- Network Engineer (3)
- Human Resources (3)
- Escalation Engineer (3)
- Field Sales Manager (3)
- Sales Specialist (3)
- Tech Support Engineer (3)
- User Experience Designer (2)
- Sales Associate (2)
7 Candidate Interview Reviews Back to all InterviewsSort: Popular Date Difficulty
Engineering Interview
I applied online. The process took a week. I interviewed at Citrix Systems (Fort Lauderdale, FL) in December 2009.
First, there was skills test thru internet, it went fine. Group phone interview went fine too, except for couple of slipups from my part of atoi implementation etc.,
Interview Questions
- general c, c++ particularly pointers oriented. Answer Question
- implementation of some C std library calls, like atoi etc., Answer Question
Other Interview Reviews for Citrix Systems
Engineering InterviewAccepted OfferPositive ExperienceAverage Interview
I applied online. The process took 2+ months. I interviewed at Citrix Systems (Santa Clara, CA) in October 2009.
Two telephone interviews followed by 4-hour onsite interviews. Typical interivew questions were asked. A 30 minute skills test was given but I felt more time should have been allocated. I don't know how much weight the skills test was given as compared to the interviews.
Interview Questions
- Would you be willing to shake things up? Answer Question
Engineering InterviewNo OfferNegative ExperienceDifficult Interview
The process took 3 days. I interviewed at Citrix Systems (Bangalore (India)) in February 2012.
3 Rounds 3 days of of goto meeting of live coding I used Java Coding language and eclipse 1st day> Asked to write some array algorithm. I wrote both optimized and non optimized solutions. (Live Coding and result in eclipse) 2st day> Square root algorithm . I wrote both optimized and non optimized solutions. (Live Coding and result in eclipse) 3> Android code. Multi threaded application on Android emulator. I wrote that successfully also using Java thread. Although the interviewer was a fan of asynctask i guess. (Live Coding and result in eclipse) After all this time waste i got a mail from HR saying cant proceed now will call you in future. If they are not sure they should not waste other people time.
Interview Questions
- Array question 1 Answer
- Find square root of a number optimally. Java Eclipse Answer Question
Engineer InterviewAccepted OfferPositive ExperienceDifficult Interview
I applied through a recruiter. The process took 5 days. I interviewed at Citrix Systems in July 2011.
First interview was a phone interview that was only technical. This interview lasted about 45 minutes and covered a broad base of technical competencies. The second interview was a panel interview which began as a one on one interview with the hiring manager and then developed into an full panel interview with a mixture of personality questions and technical questions.
Interview Questions
- How have you handled a situation where you made a mistake. Answer Question
Engineering InterviewAccepted OfferPositive ExperienceAverage Interview
I applied through a recruiter. The process took 1 day. I interviewed at Citrix Systems (Bangalore (India)) in September 2010.
The interviewers were nice guys who were looking for a specific set of skills mainly in OS and C basics. Each interview was around 25-35 minutes encompassing puzzles to basic data structure questions. All in all a fairly challenging experience.
Interview Questions
- What is better multi threading or multi tasking?? Answer Question
- Delete the third last element in a singly linked list without using extra pointers.. 2 Answers
Engineering InterviewAccepted OfferPositive ExperienceAverage Interview
The process took a week. I interviewed at Citrix Systems in July 2009.
First had a telephone interview for 1 hour. A week later was interviewed by 4 different people. Technical round was for 1.5 hours by 2 techies, followed by 2 managers and HR. Interview was well structured with a set of standard questions. Quenstions were based on OS, networking, Hardware and others. Very welcoming people and made me feel very comforatble.
Interview Questions
- Networking 1 Answer
You can negotiate
Engineering InterviewNo OfferPositive ExperienceDifficult Interview
I applied through a staffing agency. The process took 2+ weeks. I interviewed at Citrix Systems (Bangalore (India)) in July 2009.
Procedure 1) Telephonic Interview 2) Telephonic Interview (If not in Bangalore) 3) Face - 2 - Face Interview (in Bangalore) The process is difficult if you are not well versed with the basics of what you are being interviewed for. However, it is a good benchmark for yourself to set.
Interview Questions
- something related to the function's stack (C++) Answer Question
Is this helpful? The community relies on everyone sharing – Add Anonymous Interview Review


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Main Content
This item ships within one business day.
$4.99 flat rate shipping. See other shipping options.
- 100% Polyester
- Drop tail
- Fit: Jersey fits size 12 - 24 MO. It measures approximately 14" in length and 22.5" across the chest.
- Player name and number on back
- Rib-knit v-neck collar
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- Team logo on front
- Two-way stretch fabric
- Woven jock tag
Reviewed by 1 customer
- Authentic Design
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- Shows Off Team Pride
- Stylish
Best Uses
- Around Town
- At The Game
- School
- Tailgating
- Watching The Game on TV
Comments about Reebok Sidney Crosby Pittsburgh Penguins Infant Replica Home Jersey - Black:
Bought it as a gift for a friends newly one year old. Just my contribution in making a penguins fan early ;)
- Sizing:
- Feels true to size
Special event items are produced by manufacturers only after the outcome of a game or event. These are advanced sale items and will ship immediately after they are received in our warehouse.
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Hey TEC team,
I like 16px as a font size, and frequently use it, but I don't understand why you're putting that into the plugin's styles for things that the theme really should control.
For instance,
line 356 in
.events-archive .tribe-events-event-entry p, .venue-events .tribe-events-event-entry p {
font-size: 16px;
line-height: 24px;
All three of those rules override styles I _always_ set in my stylesheets, and it's a pain to have to override those.
I completely understand the need to provide _some_ styles to make the plugin look good out of the box, but that strikes me as going too far.
p.s I know I owe you a response to a different thread, still. My apologies. It's coming.


text:
Rascal Flatts with The Band Perry
Sat, Jun 15, 2013 7:00 pm
Xfinity Theatre, Hartford, CT
Sorry, this event has already taken place. Please see similar events below.
|Oct 23 Fri 8:00 PM
|Rascal Flatts
|Coushatta Casino Resort
Kinder, LA
|Oct 24 Sat 7:00 PM
|Bubba's Bash
|Pensacola Bay Center
Pensacola, FL


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If you somehow think that Benedict Cumberbatch only serves the world as Kahn and Martin Freeman's only role is as a hobbit, you would do well to remember they work splendidly together in a little BBC show called Sherlock
We can forgive your forgetfulness; it's been close to two years since we've heard anything from the detecting duo.
Nevertheless, we knew that they would return for a Christmas special later this year. And we also knew they would be going back in time for a special Edwardian/Victorian adventure.
And now, thanks to the BBC we have the first photo showing what they will look like in their 1800s duds.
According to the Evening Standard:
The 38-year-old actor's chocolate doppelganger was created to celebrate the launch of television channel Drama on the new on-demand service uktvplay.co.uk following a national poll which named the Oscar nominated star as Britain's best looking television drama actor.
Speaking to Telegraph, Martin Freeman said filming a special for Sherlock in 2015 looks pretty likely:
"If that's going to be a special - I'm speaking off-message here; if this was New Labour I'd get fired - I think that might be for next Christmas. A Christmas special. That's what I understand."
UPDATE: Steven Moffat has commented and said there will be "a special, plus a new series of three episodes — it's a record-breaking run! Of course, it's far too early to say what's coming, but we're reasonably confident that the very next thing to happen to Sherlock and John, is the very last thing you'd expect…"


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The contrast of textures and flavorscrunchy pine nuts, creamy goat cheese, acidic tomatoes, and spicy arugulaadds complexity to this simple salad. It makes a great side dish to steak or chicken or a light lunch for two.
YIELD: Makes 4 servings
ACTIVE TIME: 25 min
TOTAL TIME: 25 min
IngredientsFor vinaigrette:
- 1 teaspoon red-wine vinegar
- 1 teaspoon fresh lemon juice
- 1/2 teaspoon Dijon mustard
- 3 tablespoons olive oil
- 1/2 pound arugula, tough stems discarded
- 1/2 head chicory (white and pale-green parts only), torn into pieces (2 cups)
- 1/4 cup pine nuts, toasted
- 3/4 cup cherry tomatoes, halved
- 6 ounces soft mild goat cheese
- 8 (1/3-inch-thick) diagonal baguette slices
Preheat broiler.
Make vinaigrette:
Whisk together vinegar, lemon juice, mustard, and salt and pepper to taste and add oil in a slow stream, whisking.
Make salad:
Toss arugula, chicory, pine nuts, and tomatoes in a large bowl with just enough vinaigrette to coat, then divide among 4 plates.
Spread goat cheese on baguette slices and broil on a baking sheet 6 inches from heat until cheese is softened and edges of bread are golden, about 2 minutes.
Arrange toasts on salads and drizzle any remaining vinaigrette over cheese.
my notes
Nutritional Info
- Calories336
- Carbohydrates15 g (5%)
- Fat26 g (40%)
- Protein13 g (26%)
- Saturated Fat8 g (41%)
- Sodium347 mg (14%)
- Polyunsaturated Fat5 g
- Fiber3 g (10%)
- Monounsaturated Fat11 g
- Cholesterol20 mg (7%)


text:
Funding via Ghana Women Fund Ltd
Diana O. is divorced and has four dependents. She completed her senior high school education and has been a food vendor since 2008. She works in Elmina, selling food like cooked rice and stew. As a single parent, she is responsible for paying her children's school fees and the family utility bills.
She will use her loan to buy bags of rice and gallons of oil for cooking. She hopes to use the new profits from her business to save for a building project.
Success!! The loan was 100% repaid


text:
Wego.com recently found 6 hotels in Majorda Beach, Goa. Book last minute hotel or find great hotel deals such as Alila Diwa Hotel for US$130 per night. Save more on cheap hotels with rates from as low as US$13 per night.
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Goa Hotels 5 Star Hotels Goa 4 Star Hotels Goa 3 Star Hotels Goa Cheap Hotels Goa Cheap Accommodation Goa
Flights to Goa Flights from Goa Goa Airports Goa Airlines


text:
Source: Danica to run Nationwide
Updated: February 8, 2010, 8:46 AM ETBy David Newton | ESPN.com
DAYTONA BEACH, Fla. -- Danica Patrick will enter Saturday's Nationwide Series race at Daytona International Speedway, a source close to the situation told ESPN.com on Sunday.
The IndyCar Series star who is beginning the transition to NASCAR made the decision after finishing sixth in her stock car debut on Saturday at Daytona's ARCA race (which is not affiliated with NASCAR). An official announcement will be made Monday.
Nationwide is the Triple-A minor league of NASCAR, which features ...
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2010 Daytona 500
The 52nd running of the Daytona 500 is in the books. Live the thrill all over again.
Daytona 500 Raceday
- Hinton: It all came together for Jamie
- Newton: Furious finish for Dale Jr.
- Blount: Just a pothole in the road back
- Recap: McMurray holds off Earnhardt
- Hole in pavement causes long delays
- NASCAR Live! Daytona 500 rewind
- Hinton: Cup drivers don't disappoint
- MacGregor: NASCAR's zoom with a view
- Monday Rundown: OT shootout a hit
- McGee: Watching with a legend
- Newton: How Danica got here
- Blount: Desperately seeking Daytona
- Smith: JJ's blood, sweat and fears
- Fourth Scored: Jimmie Johnson
- Willis: Numbers favor JJ
- Blount: Earnhardt at a crossroads
- Newton: Danica-mania in high gear
- Newton: Chad Knaus' white whale
- Blount: State of NASCAR? Hopeful
- Newton: Danica running a no-brainer
- McGee's Power Rankings: JJ time
- Blount: Danica may just belong here
- Newton: Harvick happy again
- Newton: Martin's pole, Danica's spotlight
Nationwide: Drive4COPD 300
- Hinton: Early exit by Danica for best
- Blount: Danica's ups trump downs
- Newton: All eyes were on Danica
- McGee: Chrissy knew it would be hard
- NASCAR Live! replay
Gatorade Duels
- Hinton: Pinch-me moments at Daytona
- Blount: Duels hold clue to 500 success?
- Newton: Waltrip gets in with a little luck
- Duels day live recap
Driver Rankings
- The Top 12 vote | You Rank 'Em
- No. 1: Jimmie Johnson
- No. 2: Denny Hamlin
- No. 3: Mark Martin
- No. 4: Jeff Gordon
- No. 5: Kyle Busch
- No. 6: Carl Edwards
- No. 7: Juan Pablo Montoya
- No. 8: Kurt Busch
- No. 9: Tony Stewart
- No. 10: Matt Kenseth
- No. 11: Greg Biffle
- No. 12: Kasey Kahne
Team Rankings
- No. 1: Hendrick Motorsports
- No. 2: Joe Gibbs Racing
- No. 3: Stewart-Haas Racing
- No. 4: Roush Fenway Racing
- No. 5: Richard Childress Racing
- No. 6: Penske Racing
- No. 7: Michael Waltrip Racing
- No. 8: Earnhardt Ganassi Racing
- No. 9: Red Bull Racing
- No. 10: Richard Petty Motorsports
- Daytona 500 highlights
- Nicole Briscoe on a wild finish
- Dale Earnhardt Jr.'s big finish
- Harvick misses out
- Nationwide Superhighlights


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He s really rude ! :/
Thanks for helping us associate the correct Pornstars to this video!
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Jazmin slobbered all over his hard cock, thrusting it down her throat before he laid her down on the couch and thrusted it inside of her black pussy.
All Comments (50)
He s really rude ! :/
she looks like an indian girl..
she isnt black
can anyone make me scream like her????
black pussy?
Man, that cock is HUGE!
@Bad Yeah he should have shared her with others. She is rude also she didn't offer to make him a sandwich or something to eat I could look at her fine smoking hot ass all day long
She looks more East Indian than black.
she looks more Indian or Pakistani to me ...
He is an ass
That would depend on how you like it, HornyChick.
It says Black Beauty, not "Race" Beauty... definetely she doesn't have a white complexion so she can be considered as black beauty... and loving it!
c'ha un cazzo enormeeee
That is Jazmin Chaudhry who is Bangladeshi.
Yes, HornyChick, I can make you scream like that...and maybe even louder!
no moeny fuck you honey
she could be black and mixed with something but it doesnt matter.
she is hot and like how she takes a cock
thats a nice fuckin mustache ={) lol
black beauty is a movie about horses.. Nice..
i get bigger dick
please som1 fuck me like dis
that is a black pussy but she's totally indian.
I'd love to cum on her face everyday!
I love indian girlssss she are so sensually
I love indian girls
she is black,its not a race its just a stpuid name given to brown skinned people by the english slave owners.
She looks more Indian than black, but she's hot whatever her racial backround is.
Good fuck.. too much moaning.. and why don't she suck his cum soaked cock
someone noticed these green spots on her feet...? kinda ugly
im so hard want a black chick to ride my cock
Wanna fuck her pussy...damn.
horny chick i can make u scream like her
swallow that cum girl
i like her pussy very much......, i miss her.......!
shes got a great pussy. id fuck er
OMG!!! the whole sperma on her nose, very unprecisely ;)
These black chicks sure know how to please white cocks
Ou tu veut quand tu veut ...
Can I have next baby? I look White, but I'm Native American and I fuck like a Black guy, lol. You are very magnificent. Can I have next? Mad love, -ReN-
yeah that's an indian girl .. very sexy
Would fuck her so hard !!!!!!!
de belle fesse et belle chatte et belle jambes de black ;elle suce bien au fond de la gorge
YUM, She's Amazing! I'd so lick every bit of her.... ;P
Amazing look would like to meet her


text:
Scripture Union taught me the discipline of daily Bible reading..."John Stott,
Bible Expositor,
Scripture Union is supported by the generous gifts of people like you—those who are committed to meeting God every day in the Bible and prayer, and who care about reaching out to the next generation with the Good News and God's Word.
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Please consider making a tax-deductible contribution to Scripture Union for the Mid-Atlantic Region today right here online.
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Join Scripture Union now and get a whole year's worth of help for meeting God every day.


text:
Isopropyl is one of the denaturant used.
A bottle of chlorophyll powder I've seen said it was extracted from spinach. Here's a nice extraction method that should clean up your extract pretty well.
It uses acetone for the extraction, and then cleans extracts the extract by adding water and hexane. The water will mix with the acetone hold onto the acetone and other junk in the first extract, and the hexane will extract the chlorophyll from the water/acetone mix. You can then blow down/evaporate the hexane to get rid of it and make some powdered chlorophyll to use in whatever solvent you want.


text:
This blog is about to undergo a major update, improvement & a name change!
Stay tuned.
Thursday, April 15, 2010
Coming soon!!!
1 comment:
- AnonymousMarch 19, 2011 at 1:21 AM
Looking forward to the overhaul!ReplyDelete
I was wondering if there is a way to contact you regarding sustainable exhibition design? My client Marler Haley have recently begun to provide environmentally friendly banner stands and other such exhibition items, and I was hoping you might write something about them.
I can give you more information over e-mail but for now their site can be found at www.marlerhaley.com/
Many thanks,
Dane Cross
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Viewing All 41 Photos
Certified photos by travelers like you.
South Rim of the Grand Canyon
May 2013
Tavis T
First trip to the Grand Canyon for the wife and I and it was AWESOME.
The steam engine
February 2013
The engine sitting in the station yard -used on their special trips
Grand Canyon
November 2010
United States of America
South Rim
White Water Grand Canyon Rafting Tour
April 2015
Beginning of White Water Grand Canyon Rafting Tour
Rainbow in the Grand Canyon
December 2014
Snowed in the morning, but clouds broke up by the time we got to the Grand Canyon. Moisture in the air created a rainbow...bonus!
Great view!
December 2014
The sign where we were standing said we were seeing the peaks that were 62 miles away.
Pretty drive from Sedona to Flagstaff
December 2014
Snowy day - glad Chris was driving!
Snow on the Grand Canyon Rim
December 2014
Dan and Barb F. in December 2014
View from scenic point on Rim Trail
November 2014
Grand Canyon - view from scenic point on Rim Trail
October 2014
Sunset on the way home from Grand Canyon, Oct. 6, 2014
Grand Canyon views
October 2014
One of many stops along our tour, Oct. 6, 2014
Grand Canyon view
July 2014
One of the most amazing sites on earth, no photo can really do it justice.
fantastic white water rafting into Grand Canyon
July 2014
My two kids braving the Colorado River rapids into Grand Canyon. Great water! Stunning setting! Awesome day!
The western Shoot out before we boarded the train to the Grand Canyon
March 2014
Love the Cowboy show at Williams AR
Train at the station at the Grand Canyon
March 2014
Just some of the train to the canyon


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Book your room at Hallmark Hotel Carlisle
Please enter your travel dates.
Get an overview of this hotelFamily-friendly hotel with restaurant and bar/lounge
This family-friendly Carlisle hotel is within a 10-minute walk of Green Market, Tullie House Museum and Gallery, and Carlisle Guildhall. Carlisle Cathedral and Carlisle Castle are also within 15 minutes.
Hotel Features
A restaurant, a bar/lounge, and self parking are available at this smoke-free hotel. WiFi in public areas is free. Additionally, 24-hour room service, conference rooms, and meeting rooms are onsite.
Room Amenities
All 70 rooms feature modern comforts like plasma TVs with satellite channels, along with free WiFi. 24-hour room service, coffee makers, and hair dryers are among the other amenities available to guests.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
The hotel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. High-speed wireless Internet access is complimentary. Event facilities measuring 54 square feet (5 square meters) include conference space and meeting rooms. This Victorian hotel also offers dry cleaning/laundry services, 24-hour room service, and discounted use of a nearby fitness facility. Limited onsite parking is available on a first-come, first-served basis (surcharge).
Hallmark Hotel Carlisle is a smoke-free property.
- 24-hour front desk
- Bar/lounge
- Breakfast available (surcharge)
- Conference space
- Conference space size (feet) - 54
- Conference space size (meters) - 5
- Dry cleaning/laundry service
- Elevator/lift
- Free WiFi
- Luggage storage
- Meeting rooms
- Number of floors - 3
- Number of meeting rooms - 5
- Parking (limited spaces)
- Restaurant
- Self parking (surcharge)
- Smoke-free property
- Total number of rooms - 70
- Use of nearby fitness center (discount)
Room Amenities
- Climate control
- Coffee/tea maker
- Free toiletries
- Cribs/infant beds available
- Daily housekeeping
- Desk
- Free WiFi
- Hair dryer
- Iron/ironing board (on request)
- Plasma TV
- Private bathroom
- Room service (24 hours)
- Satellite TV service
Where to Eat
Full breakfasts are available for a surcharge.
The Brasserie - Onsite brasserie. Guests can enjoy drinks at the bar. A children's menu is available.
24-hour room service is available.
Hotel Policies
Check-in time starts at 2 PM
Check-out time is 11 AM
Payment types
Children and extra beds
- Children are welcome.
- Cribs (infant beds) are available.
Pets allowed, Only dogs are allowed
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
Optional extras
- Fee for full breakfast: GBP 9.95 per person (approximately)
- Pet fee: GBP 10 per pet, per night
We should mention
Guests can arrange to bring pets by contacting the property directly, using the contact information on the booking confirmation (surcharges apply and can be found in the Fees section).


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I had my first baby in this hospital. Very happy with the service, especially the midwifes in the nursery. I am very glad that they have multi language midwives in the nursery. Special thanks to Mandy and Shella( both working on Thursday night and Friday night ) for the encouragement in breast feeding. Definately come back for my second baby. The head nurse Helen is also a very wonderful person. Hope they still there when I have my second baby.
Had my first baby here and what an amazing experience. Wonderful care. Lovely rooms for you and your partner to share this amazing experience. They can stay with you and feel very comfortable
I stayed in this hospital for 4 nights and it is what you would expect from a private hospital. Nothing more, nothing less. The staff are lovely and work very hard. I could not fault them on anything. The food - well I was nil by mouth so sorry I cannot review that bit. The tv was disappointing. There were only 3 channels (7, 9 and 10) and when you are bedridden this can start to grind. I was surprised that they did not even have digital. Other private hospital even have Foxtel - but not Norwest. There is no WiFi. It was an ok hospital but I did expect the facilities to patients to be a bit more modern considering it is a reasonably new hospital.
This hospital was only opened late in 2009, and was my first choice when having my baby. The quality of the hospital is sensational, as were the staff including my midwives. I felt rather comfortable during this stressful period, right from the time I started contractions to the day I left with my healthy newborn. I had ongoing support and assistance throughout my entire experince and was always happy with the service I received. The midwives assisted all areas required in the maternity unit including assistance with breastfeeding, exercises, paedeatric help and even bathing the bubs. Even the food was quite good! I would recommend this hospital to anyone, and I will definitely be back for future babies!
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It looks like NFL commissioner Roger Goodell has found himself another supporter when it comes to how he's handled the New Orleans Saints bounty scandal.
Philadelphia Eagles head coach Andy Reid thinks the Goodell and the NFL have done a great job.
"I think the league's done a great job, and I think if you look at the big picture of Roger Goodell, people kind of micro-analyze him, I think. You have to look at the things that he's doing he feels are the best for the game," Reid said in a recent interview.
"He's making people accountable for their work and what they say and what they do, and I don't think that's bad," Reid said. "Do people like change? No, people don't like change, so there's going to be people that gripe … but I think for the betterment of the game, for the betterment of the NFL, I think he's keeping perspective on that."
Reid made it clear that he doesn't agree with bounties and is in support of what Goodell has done to punish the Saints.
"I don't agree with bounties," Reid said. "I know I don't believe in that, and I know I support what the commissioner did."
Reid understand players want to deliver big hits, but they don't need to try to end an opposing player's career.
"When you talk to the players, do they want to put a nice hit on somebody? Absolutely. Do they want to maim them, hurt them where they can't make a living? No," Reid said. "Guys don't want to ruin another man's career."Follow PFZ on Twitter @ProFootballZone