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Liste des publications
|2014, "Physical inactivity, insulin resistance, and the oxidative-inflammatory loop", Free Radic Res.. Vol. 48(1), pp. 93-108.
|Abstract: Epidemiological data indicate that physical inactivity, a main factor of global energetic imbalance, is involved in the worldwide epidemic of obesity and metabolic disorders such as insulin resistance. Although the complex pathogenesis of insulin resistance is not fully understood, literature data accumulated during the past decades clearly indicate that the activation of the oxidative-inflammatory loop plays a major role. By activating the oxidative-inflammatory loop in insulin-sensitive tissues, fat gain and adipose tissue dysfunction likely contribute to induce insulin resistance during chronic and prolonged physical inactivity. However, in the past years, evidence has emerged showing that early insulin resistance also occurs after very short-term exposure to physical inactivity (1-7 days) without any fat gain or energetic imbalance. The possible role of liver disturbances or endothelial dysfunction is suggested, but further studies are necessary to really conclude. Inactive skeletal muscle probably constitutes the primary triggering tissue for the development of early insulin resistance. In the present review, we discuss on the current knowledge about the effect of physical inactivity on whole-body and peripheral insulin sensitivity, and how local inflammation and oxidative stress arising with physical inactivity could potentially induce insulin resistance. We assume that early muscle insulin resistance allows the excess nutrients to shift in the storage tissues to withstand starvation through energy storage. We also consider when chronic and prolonged, physical inactivity over an extended period of time is an underestimated contributor to pathological insulin resistance and hence indirectly to numerous chronic diseases.
@article{Gratas-Delamarche-2014, author = {Gratas-Delamarche, Arlette and Derbré, Frédéric and Vincent, Sophie and Cillard, Josiane}, title = {Physical inactivity, insulin resistance, and the oxidative-inflammatory loop}, journal = {Free Radic Res.}, year = {2014}, volume = {48(1)}, pages = {93-108}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24060092} }
|2014, "Mitochondrial fission and fusion in human diseases.", N Engl J Med.. Vol. 370(11), pp. 1073-4..
@article{Sanchis-Gomar-2014, author = {Sanchis-Gomar, F and Derbré, F}, title = {Mitochondrial fission and fusion in human diseases.}, journal = {N Engl J Med.}, year = {2014}, volume = {370(11)}, pages = {1073-4.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/24620885} }
|2013, "Recovery (Passive vs. Active) during interval training and plasma catecholamine responses.", Int J Sports Med. Vol. 34(8), pp. 742-747.
|Abstract: Abstract
The effect of recovery mode (Active [AR] vs. Passive [PR]) on plasma catecholamine (Adrenaline [A] and Noradrenaline [NA]) responses to maximal exercise (Exemax) was studied during interval training (IT). 24 male subjects (21.1±1.1 years) were randomly assigned to a control group (CG, n=6), AR training group (ARG, n=9) or PR group (PRG, n=9). ARG and PRG participated in an IT program 3 times a week for 7 weeks. Before and after training, maximal oxygen uptake (VO2max) and maximal aerobic velocity (MAV) were measured. Plasma A and NA were determined at rest, at the end of Exemax and after 10 and 30 min of recovery. Training induced significant changes only in ARG: an increase of VO2max and MAV along with a significant increase of A and NA at the end of Exemax (2.82±0.15 vs. 1.03±0.15 nmol/l and 7.22±0.36 vs. 6.65±0.57 nmol/l, respectively p<0.05). The ratio A/NA measured at the end of Exemax also increased significantly after training (0.41±0.11 vs. 0.16±0.08, P>0.05). The present results show that IT with AR induces a significant increase of A and NA concentrations in response to maximal exercise. The study furthermore shows that IT program with AR may induce more stress than the same program with PR.
@article{Abderrahmane-2013, author = {Abderrahmane, A B and Prioux ,Jacques and Mrizek, I and Chamari, K and Tabka, Z and Bouslama, A and Zouhal, Hassane}, title = {Recovery (Passive vs. Active) during interval training and plasma catecholamine responses.}, journal = {Int J Sports Med}, year = {2013}, volume = {34(8)}, pages = {742-747}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23444090}, doi = {10.1055/s-0032-1327697} }
|2013, "Effects of recovery mode (active vs. passive) on performance during a short high-intensity interval training program: a longitudinal study.", Eur J Appl Physiol.. Vol. 113(6), pp. 1373-1383..
@article{Abderrahmane-2013a, author = {Abderrahmane, A B and Zouhal, Hassane and Chamari, K and Thevenet, Delphine and De Mullenheim, PY and Gastinger, Steven and Tabka, Z and Prioux, Jacques}, title = {Effects of recovery mode (active vs. passive) on performance during a short high-intensity interval training program: a longitudinal study.}, journal = {Eur J Appl Physiol.}, year = {2013}, volume = {113(6)}, pages = {1373-1383.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23229881}, doi = {10.1007/s00421-012-2556-9} }
|2013, "Association of Short-Passing Ability with Athletic Performances in Youth Soccer Players.", Asian J Sports Med.. Vol. 4(1), pp. 41-48.
|Abstract: Abstract
This study was designed to examine the relationship between multiple short-passing ability [measured using the Loughborough Soccer Passing Test (LSPT)] and athletic performances in youth soccer players.
Forty-two young soccer players (age 14.8±0.4years) performed the LSPT, the squat-jump (SqJ), the counter movement jump (CMJ), the 30m sprints (with 5m and 20m split times also recorded), the 15m agility run (Agility-15m), the 15m ball dribbling (Ball-15m), the Illinois agility test (IAGT) and the Yo-Yo IRT Level 1 tests.
LSPT total performance (LSPT TP) showed significant positive correlation with 5m, 20m, and 30m sprint times, Agility-15m, Ball-15m and Illinois agility test (r=0.60, r=0.58, r=0.49, r=0.75, r=0.71 and r=0.72; P<0.01, respectively). Significant negative correlation were found between LSPT TP and SqJ and CMJ (r=-0.62 and r=-0.64; P<0.01, respectively). It was determined that Agility-15m, Illinois agility test and Ball-15m were the most effective factors associated with LSPT TP among other factors in multiple regression analysis.
This study showed that LSPT TP of young elite soccer players is determined by their agility abilities, thus enabling this test to be used for talent identification purposes.
@article{Benounis-2013, author = {Ben Ounis, O and Benabderrahman, A and Chamari, K and Ajmol, A and A and Benbrahim, M and Hammouda, A and , Hammami, MA and Zouhal, Hassane}, title = {Association of Short-Passing Ability with Athletic Performances in Youth Soccer Players.}, journal = {Asian J Sports Med.}, year = {2013}, volume = {4(1)}, pages = {41-48}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23785575 http://www.ncbi.nlm.nih.gov/pubmed/23785575} }
|2013, "KeR-EGI, a new index of gait quantification based on electromyography", Journal of Electromyography and Kinesiology. Vol. 23(4), pp. 930-937. Elsevier.
|Abstract: Purpose
To define a new index of gait pathology in adults based on electromyographic data: the Ker-EGI for Kerpape-Rennes EMG-based Gait Index. The principle is similar to the one of Gait Deviation Index but using EMG profiles instead of joint angles. It first needs to build a database of healthy subjects gait to be able then to quantify the deviation of one peculiar patient's gait from this typical behavior.
Ninety adults (59 healthy and 31 pathological) participated to this study. All pathological subjects had a diagnosis of central nervous system disorder. On each subject we collected the joint angles and the activation profile of seven muscles of each lower limb. Moreover, we recorded two videos (face and profile) of each patient to compute his/her Edinburgh Visual Gait Score (EVGS). Then for each patient, we computed the GGI (Gillette Gait Index), the GDI (Gait Deviation Index) and the Ker-EGI.
Correlation Ker-EGI and each of the three kinematical indices (GGI, GDI, EVGS) is fair to good (respectively R2 = 0.62, 0.42, and 0.69).
KeR-EGI is a valid index to evaluate gait and is complementary to one of these three kinematical indices providing synthetic vision on patients' motor control abilities.
@article{Bervet-2013a, author = {Bervet, Kristell and Bessette, Manon and Godet, Lucille and Crétual, Armel}, title = {KeR-EGI, a new index of gait quantification based on electromyography}, journal = {Journal of Electromyography and Kinesiology}, publisher = {Elsevier}, year = {2013}, volume = {23}, number = {4}, pages = {930--937}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23507426} }
|2013, "Cytoprotective and antioxidant effects of the edible halophyte Sarcocornia perennis L. (swampfire) against lead-induced toxicity in renal cells.", Ecotoxicol Environ Saf., Sep, 2013. Vol. 95, pp. 44-51.
|Abstract: Lead (Pb) exposure is considered as a risk factor responsible for renal impairment in humans. On the other hand, the halophyte Sarcocornia perennis is a fresh vegetable crop suitable for leafy vegetable production. This study was designed to evaluate the in vitro protective activity of S. perennis against lead-induced damages in HEK293 kidney cells. Morphological and biochemical indicators were used to assess cytotoxicity and oxidative damages caused by Pb treatment on the cells. Our results showed that lead induced (1) a decrease in cell viability (MTT), (2) cell distortion and cohesion loss, (3) superoxide anion production and lipid peroxidation. Conversely, addition of S. perennis extract to the lead-containing medium alleviated every above syndrome. Thus, cell survival was increased and the production of reactive oxygen species caused by Pb treatment was inhibited. Taken together, our study revealed that S. perennis has potent cytoprotective effect against Pb-induced toxicity in HEK 293 cell. Such action would proceed through the decrease in ROS levels and resulting oxidative stress, which suggests a potential interest of this halophyte in the treatment of oxidative-stress related diseases.
@article{Gargouri2013, author = {Gargouri, Manel and Magné, Christian and Dauvergne, Xavier and Ksouri, Riadh and El Feki, Abdelfattah and Metges, Marie-Agnès Giroux and Talarmin, Hélène}, title = {Cytoprotective and antioxidant effects of the edible halophyte Sarcocornia perennis L. (swampfire) against lead-induced toxicity in renal cells.}, journal = {Ecotoxicol Environ Saf}, year = {2013}, volume = {95}, pages = {44--51}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23755863}, doi = {10.1016/j.ecoenv.2013.05.011} }
|2013, "ICU acquired neuromyopathy.", Ann Fr Anesth Reanim., Aug, 2013. Vol. 32(9), pp. 580-591.
|Abstract: ICU acquired neuromyopathy (IANM) is the most frequent neurological pathology observed in ICU. Nerve and muscle defects are merged with neuromuscular junction abnormalities. Its physiopathology is complex. The aim is probably the redistribution of nutriments and metabolism towards defense against sepsis. The main risk factors are sepsis, its severity and its duration of evolution. IANM is usually diagnosed in view of difficulties in weaning from mechanical ventilation, but electrophysiology may allow an earlier diagnosis. There is no curative therapy, but early treatment of sepsis, glycemic control as well as early physiotherapy may decrease its incidence. The outcomes of IANM are an increase in morbi-mortality and possibly long-lasting neuromuscular abnormalities as far as tetraplegia.
@article{Gueret2013, author = {Gueret, G. and Guillouet, M. and Vermeersch, V. and Guillard, E. and Talarmin, H. and Nguyen, B-V. and Rannou, F. and Giroux-Metges, M-A. and Pennec, J-P. and Ozier, Y.}, title = {ICU acquired neuromyopathy.}, journal = {Ann Fr Anesth Reanim}, year = {2013}, volume = {32(9)}, pages = {580-591}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23958176}, doi = {10.1016/j.annfar.2013.05.011} }
|2013, "Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF).", Cytokine., Jul, 2013. Vol. 63(1), pp. 52-57.
|Abstract: One of the main factor involved neuromyopathy acquired in intensive care unit (ICU) appears to be sepsis. It induces the release of many pro- and anti-inflammatory factors which can directly modulate the muscle excitability. We have studied the effects of one of them: the ciliary nervous trophic factor (CNTF) which is a cytokine released in the early phase of sepsis. CNTF induces a decrease in the sodium current and an increase in resting potential as in sodium inversion potential. These effects could participate to the hypo-excitability observed during sepsis and could be involved in the ICU acquired neuromyopathy. As for TNFα, this early effect is mainly mediated by protein kinase C (PKC) activation and appears to be a reversible post-transcriptional effect.
@article{Guillard2013, author = {Guillard, Emilie and Gueret, Gildas and Guillouet, Maité and Vermeersch, Véronique and Rannou, Fabrice and Giroux-Metges, Marie-Agnès and Pennec, Jean-Pierre}, title = {Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF).}, journal = {Cytokine}, year = {2013}, volume = {63}, number = {1}, pages = {52--57}, url = {http://www.ncbi.nlm.nih.gov/pubmed/?term=Alteration+of+muscle+membrane+excitability+in+sepsis%3A+possible+involvement+of+ciliary+nervous+trophic+factor+(CNTF).}, doi = {10.1016/j.cyto.2013.04.023} }
|2013, "Tumor Necrosis Factor alpha induced hypoexcitability in rat muscle evidenced in a model of ion currents and action potential.", Cytokine., Oct, 2013. Vol. 64(1), pp. 165-171.
|Abstract: Sepsis and Tumor Necrosis Factor alpha (TNFα), a major pro-inflammatory mediator, have previously been shown to induce a decrease in the conductance of voltage-dependent sodium channels (NaV). Moreover, TNFα increased resting membrane potential, leading to hyperpolarization. NaV and resting potential are the two major factors of membrane excitability. Then we hypothesis that TNFα can decrease muscle membrane excitability. To evidence that role of TNFα, we carried out a simulation of the sodium and potassium currents and action potential (AP) of isolated muscle fibre. We used a computer model based on Hodgkin and Huxley equations, but also taking into account the sodium-potassium pump current. Our first aim was to optimise this model in control conditions according to our measurements of currents. Then the model was modified to fit the values measured experimentally in TNFα-containing medium in order to determine the modifications induced in the currents and hence in AP triggering. Our model provides a very good fit with experimental data on the ion currents. Moreover, it clearly shows that the triggering level of AP is increased in TNFα-containing medium, thus corresponding to a decreased excitability.
@article{Guillouet2013, author = {Guillouet, Maïté and Rannou, Fabrice and Giroux-Metges, Marie-Agnès and Droguet, Mickael and Pennec, Jean-Pierre}, title = {Tumor Necrosis Factor alpha induced hypoexcitability in rat muscle evidenced in a model of ion currents and action potential.}, journal = {Cytokine}, year = {2013}, volume = {64}, number = {1}, pages = {165--171}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23911204}, doi = {10.1016/j.cyto.2013.07.007} }
|2013, "Effects of a soccer season on anthropometric characteristics and physical fitness in elite young soccer players.", Journal of Sport Sciences. Vol. 31(6), pp. 589-596..
|Abstract: Abstract
The aim of this study was to evaluate the effect of a soccer-training season on the anthropometric and performance characteristics of elite youth soccer players. Two groups (age: 14.4 years) participated in this study: (1) 24 soccer players training 8 to 10 hours per week and (2) 26 non-athletic boys used as controls. Anthropometric measurements, aerobic (Yo-Yo Intermittent Recovery test level 1) and anaerobic (counter-movement-jump (CMJ), squat-jump (SqJ), five-jump-test (5JT), and speed (T5m, 10 m, 30 m)) performances were assessed twice during 8 months (T0: October; T1: May) of the competitive season. Data showed significant differences in height and weight at T0 between the two groups (P < 0.05), while no difference in the percentage of body fat (%BF) was observed. However, the soccer players were significantly taller and had lower %BF than age-matched controls at T1. Compared to the controls, the soccer players attained better results in the physical fitness test (P < 0.05) at T0 and T1 except in (T5m) sprinting speed. Hence, significant improvements (P < 0.05) in physical parameters were observed between T0 and T1 only in soccer players. The results demonstrate that soccer-training season was able to provide maturation free improvement in anthropometric and performance characteristics in young soccer players during the training season.
@article{Hammami-2013, author = {Hammami, MA and Ben Abderrahman and Nebigh, A and Le Moal, Emmeran and Ben Ounis, O and Tabka, Z and Zouhal, Hassane}, title = {Effects of a soccer season on anthropometric characteristics and physical fitness in elite young soccer players.}, journal = {Journal of Sport Sciences}, year = {2013}, volume = {31(6)}, pages = {589-596.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23181693} }
|2013, "Effect of human skin explants on the neurite growth of the PC12 cell line.", Exp Dermatol., Mar, 2013. Vol. 22(3), pp. 224-225.
|Abstract: The skin is a densely innervated organ. After a traumatic injury, such as an amputation, burn or skin graft, nerve growth and the recovery of sensitivity take a long time and are often incomplete. The roles played by growth factors and the process of neuronal growth are crucial. We developed an in vitro model of human skin explants co-cultured with a rat pheochromocytoma cell line differentiated in neuron in presence of nerve growth factor (NGF). This model allowed the study of the influence of skin explants on nerve cells and nerve fibre growth, probably through mediators produced by the explant, in a simplified manner. The neurite length of differentiated PC12 cells co-cultured with skin explants increased after 6 days. These observations demonstrated the influence of trophic factors produced by skin explants on PC12 cells.
@article{Lebonvallet2013, author = {Lebonvallet, Nicolas and Pennec, Jean-Pierre and Le Gall, Christelle and Pereira, Ulysse and Boulais, Nicholas and Cheret, Jeremy and Jeanmaire, Christine and Danoux, Louis and Pauly, Gilles and Misery, Laurent}, title = {Effect of human skin explants on the neurite growth of the PC12 cell line.}, journal = {Exp Dermatol}, year = {2013}, volume = {22}, number = {3}, pages = {224--225}, url = {http://www.ncbi.nlm.nih.gov/pubmed/?term=Effect+of+human+skin+explants+on+the+neurite+growth+of+the+PC12+cell+line.}, doi = {10.1111/exd.12095} }
|2013, "A fermented soy permeate improves the skeletal muscle glucose level without restoring the glycogen content in streptozotocin-induced diabetic rats", Journal of Medicinal Food. Vol. 16 (2), pp. 176-179.
|Abstract: Exercise is essential into the therapeutic management of diabetic patients, but their level of exercise tolerance is lowered due to alterations of glucose metabolism. As soy isoflavones have been shown to improve glucose metabolism, this study aimed to assess the effects of a dietary supplement containing soy isoflavones and alpha-galactooligosaccharides on muscular glucose, glycogen synthase (GSase), and glycogen content in a type 1 diabetic animal model. The dietary supplement tested was a patented compound, Fermented Soy Permeate (FSP), developed by the French Company Sojasun Technologies. Forty male Wistar rats were randomly assigned to control or diabetic groups (streptozotocin, 45 mg/kg). Each group was then divided into placebo or FSP-supplemented groups. Both groups received by oral gavage, respectively, water or diluted FSP (0.1 g/day), daily for a period of 3 weeks. At the end of the protocol, glycemia was noticed after a 24-h fasting period. Glucose, total GSase, and the glycogen content were determined in the skeletal muscle (gastrocnemius). Diabetic animals showed a higher blood glucose concentration, but a lower glucose and glycogen muscle content than controls. Three weeks of FSP consumption allowed to restore the muscle glucose concentration, but failed to reduce glycemia and to normalize the glycogen content in diabetic rats. Furthermore, the glycogen content was increased in FSP-supplemented controls compared to placebo controls. Our results demonstrated that diabetic rats exhibited a depleted muscle glycogen content (-25%). FSP-supplementation normalized the muscle glucose level without restoring the glycogen content in diabetic rats. However, it succeeded to increase it in the control group (+20%).
@article{Malarde-2013a, author = {Malardé, Ludivine and Vincent, Sophie and Lefeuvre-Orfila, Luz and Efstathiou, Theo and Groussard, Carole and Gratas-Delamarche, Arlette}, title = {A fermented soy permeate improves the skeletal muscle glucose level without restoring the glycogen content in streptozotocin-induced diabetic rats}, journal = {Journal of Medicinal Food}, year = {2013}, volume = {16 (2)}, pages = {176-179}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23356441}, doi = {10.1089/jmf.2012.0095} }
|2013, "Professional tennis players' serve: correlation between segmental angular momentums and ball velocity", Sports Biomechanics. Vol. 12(1), pp. 2-14..
@article{Martin-2012c, author = {Martin, Caroline and Kulpa, Richard and Delamarche, Paul and Bideau, Benoit}, title = {Professional tennis players' serve: correlation between segmental angular momentums and ball velocity}, journal = {Sports Biomechanics}, year = {2013}, volume = {12(1)}, pages = {2-14.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23724603} }
|2013, "Upper limb joint kinetic analysis during tennis serve: assessment of competitive level on efficiency and injury risks", Scandinavian Journal of Medicine and Science in Sports. Vol. -, pp. doi: 10.1111/sms.12043.
@article{Martin-2013a, author = {Martin, Caroline and Bideau, Benoit and Ropars, Michael and Delamarche, Paul and kulpa, Richard}, title = {Upper limb joint kinetic analysis during tennis serve: assessment of competitive level on efficiency and injury risks}, journal = {Scandinavian Journal of Medicine and Science in Sports}, year = {2013}, volume = {-}, pages = {doi: 10.1111/sms.12043}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23293868}, doi = {10.1111/sms.12043} }
|2013, "Identification of Temporal Pathomechanical Factors during the Tennis Serve", Med Sci Sports Exerc.
Med Sci Sports Exerc. 2013 May 7. [Epub ahead of print]., May, 2013. Vol. May 7. [Epub ahead of print], pp. May 7. [Epub ahead of print].
@article{Martin-2013b, author = {Martin, Caroline and Kulpa, Richard and Ropars, Mickael and Delamarche, Paul and Bideau, Benoit}, title = {Identification of Temporal Pathomechanical Factors during the Tennis Serve}, journal = {Med Sci Sports Exerc.
|2013, "Collision avoidance between two walkers: Role-dependent strategies", Gait & posture. Vol. 38(4), pp. 751-756. Elsevier.
|Abstract: This paper studies strategies for collision avoidance between two persons walking along crossing trajectories. It has been previously demonstrated that walkers are able to anticipate the risk of future collision and to react accordingly. The avoidance task has been described as a mutual control of the future distance of closest approach, MPD (i.e., Mininum Predicted Distance). In this paper, we studied the role of each walker in the task of controlling MPD. A specific question was: does the walker giving way (2nd at the crossing) and the one passing first set similar and coordinated strategies? To answer this question, we inspected the effect of motion adaptations on the future distance of closest approach. This analysis is relevant in the case of collision avoidance because subtle anticipatory behaviors or large last moment adaptations can finally yield the same result upon the final crossing distance. Results showed that collision avoidance is performed collaboratively and the crossing order impacts both the contribution and the strategies used: the participant giving way contributes more than the one passing first to avoid the collision. Both walkers reorient their path but the participant giving way also adapts his speed. Future work is planned to investigate the influence of crossing angle and TTC on adaptations as well as new types of interactions, such as intercepting or meeting tasks.
@article{Olivier-2013a, author = {Olivier, Anne-Hélène and Marin, Antoine and Crétual, Armel and Berthoz, Alain and Pettré, Julien}, title = {Collision avoidance between two walkers: Role-dependent strategies}, journal = {Gait & posture}, publisher = {Elsevier}, year = {2013}, volume = {38}, number = {4}, pages = {751--756}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23665066} }
|2013, "Comparaison des interactions cognition-locomotion chez des sujets jeunes et chez des séniors jeunes et âgés : mise en évidence par la double-tâche Mar-MOT'", Neurophysiologie Clinique/Clinical Neurophysiology. Vol. 42(6), pp. 406.
@article{Pothier-2013, author = {Pothier, Kristell and Benguigui, Nicolas and Dubois, Anthony and Kulpa, Richard and Chavoix, Chantal}, title = {Comparaison des interactions cognition-locomotion chez des sujets jeunes et chez des séniors jeunes et âgés : mise en évidence par la double-tâche Mar-MOT'}, journal = {Neurophysiologie Clinique/Clinical Neurophysiology}, year = {2013}, volume = {42(6)}, pages = {406}, url = {http://www.sciencedirect.com/science/article/pii/S0987705312003449} }
|2013, "Prostate cancer and physical activity: Adaptive response to oxidative stress.", Free Radic Biol Med.. Vol. 60C, pp. 115-124.
|Abstract: Abstract
Prostate cancer is the most common form of cancer affecting men in the Western world. Its relative incidence increases exponentially with age and a steady increase is observed with extended life span. A sedentary lifestyle represents an important risk factor and a decrease in prostate cancer prevalence is associated with exercise. However, the molecular mechanisms involved in this process remain unknown. We hypothesize that reactive oxygen species generated by physical exercise are a key regulatory factor in prostate cancer prevention. Aging is correlated with increased oxidative stress (OS), which in turn provides a favorable environment for tumorigenesis. Running training is known to enhance the antioxidant defense system, reducing oxidative stress. In this context, the decrease in OS induced by exercise may delay the development of prostate cancer. This review focuses on oxidative stress-based mechanisms leading to prostate cancer sensitization to exercise, which could have some impact on the development of novel cancer therapeutic strategies.
@article{Rebillard-2013, author = {Rebillard, Amelie and Lefeuvre-Orfila, Luz and Gueritat, Jordan and Cillard, Josiane}, title = {Prostate cancer and physical activity: Adaptive response to oxidative stress.}, journal = {Free Radic Biol Med.}, year = {2013}, volume = {60C}, pages = {115-124}, url = {http://www.ncbi.nlm.nih.gov/pubmed/?term=10.1016%2Fj.freeradbiomed.2013.02.009}, doi = {10.1016/j.freeradbiomed.2013.02.009} }
|2013, "Dealing with variability when recognizing user's performance in natural 3D gesture interfaces", International Journal of Pattern Recognition and Artificial Intelligence. Vol. DOI: 10.1142/S0218001413500237, pp. DOI: 10.1142/S0218001413500237.
|Abstract: Recognition of natural gestures is a key issue in many applications including videogames and other immersive applications. Whatever is the motion capture device, the key problem is to recognize a motion that could be performed by a range of different users, at an interactive frame rate. Hidden Markov Models (HMM) that are commonly used to recognize the performance of a user however rely on a motion representation that strongly affects the overall recognition rate of the system. In this paper, we propose to use a compact motion representation based on Morphology-Independent features and we evaluate its performance compared to classical representations. When dealing with 15 very similar upper limb motions, HMM based on Morphology-Independent features yield significantly higher recognition rate (84.9%) than classical Cartesian or angular data (70.4% and 55.0%, respectively). Moreover, when the unknown motions are performed by a large number of users who have never contributed to the learning process, the recognition rate of Morphology-Independent input feature only decreases slightly (down to 68.2% for a HMM trained with the motions of only one subject) compared to other features (25.3% for Cartesian features and 17.8% for angular features in the same conditions). The method is illustrated through an interactive demo in which three virtual humans have to interactively recognize and replay the performance of the user. Each virtual human is associated with a HMM recognizer based on the three different input features.
@article{Sorel2013, author = {Anthony Sorel and Richard Kulpa and Emmanuel Badier and Franck Multon}, title = {Dealing with variability when recognizing user's performance in natural 3D gesture interfaces}, journal = {International Journal of Pattern Recognition and Artificial Intelligence}, year = {2013}, volume = {DOI: 10.1142/S0218001413500237}, pages = {DOI: 10.1142/S0218001413500237}, url = {http://www.worldscientific.com/doi/abs/10.1142/S0218001413500237?journalCode=ijprai} }
|2013, "Intense exercise training is not effective to restore the endothelial NO-dependent relaxation in STZ-diabetic rat aorta.", Cardiovasc Diabetol.. Vol. 2:32. doi: 10.1186/1475-2840-12-32., pp. doi: 10.1186/1475-2840-12-32..
@article{Zguira-2013, author = {Zguira, MS and Vincent, Sophie and Le Douairon-Lahaye, Solène and Malardé, Ludivine and Tabkan Z and Saïag, B}, title = {Intense exercise training is not effective to restore the endothelial NO-dependent relaxation in STZ-diabetic rat aorta.}, journal = {Cardiovasc Diabetol.}, year = {2013}, volume = {2:32. doi: 10.1186/1475-2840-12-32.}, pages = {doi: 10.1186/1475-2840-12-32.}, url = {http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599941/}, doi = {10.1186/1475-2840-12-32} }
|2013, "Catecholamine and Obesity: Effects of Exercise and Exercise Training.", Sports Med. Vol. 43(7), pp. 591-600.
|Abstract: Abstract
Excess body fat in obese individuals can affect the catecholamine response to various stimuli. Indeed, several studies report lower plasma catecholamine concentrations in obese subjects compared with nonobese subjects in response to submaximal or maximal exercise. This low catecholamine response reflects decreased sympathetic nervous system (SNS) activity. Although the relationship between the SNS and obesity is not well established, some authors have suggested that low SNS activity may contribute to the development of obesity. A decreased catecholamine response could affect α- and β-adrenoceptor sensitivity in adipose tissue, reducing lipolysis and increasing fat stores. Few studies have examined the effects of obesity on the plasma catecholamine response at rest and during exercise in adolescents. It is interesting to note that the effects of age, sex, and degree of obesity and the impact of very intense exercise on the catecholamine response have not yet been well examined. Moreover, the hormonal concentrations measured in the majority of obesity studies did not take into account plasma volume changes. This methodological factor can also undoubtedly influence plasma catecholamine results.
@article{Zouhal-2013, author = {Zouhal, Hassane and Lemoine-Morel, Sophie and Mathieu, ME and Casazz, GA and Jabbour, G}, title = {Catecholamine and Obesity: Effects of Exercise and Exercise Training.}, journal = {Sports Med}, year = {2013}, volume = {43(7)}, pages = {591-600}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23613311} }
|2012, "Running interval training and estimated plasma volume variation.", International Journal of Sports Physiology and Performance.. Vol. 30 octobre 2012, pp. 30 octobre 2012.
|Abstract: Abstract
The effect of endurance interval training (IT) on haematocrit (Ht), haemoglobin (Hb) and estimated plasma volume variation (PVV) in response to maximal exercise was studied in 15 male subjects (21.1±1.1 years, control group (CG) n=6, and training group (TG), n=9). Training group participated in interval training 3-times a week for 7-weeks. A maximal graded test (GXT) was performed to determine maximal aerobic power (MAP) and maximal aerobic speed (MAS) both before and after the training program. To determine Ht and Hb and lactate concentrations, blood was collected at rest, at the end of GXT and after 10- and 30-min of recovery. Maximal aerobic power and maximal aerobic speed increased significantly (p<0.05) after training only in training group. Haematocrit determined at rest was significantly lower in training group than control group after the training period (p<0.05). Interval training induced a significant increase of estimated plasma volume variation at rest for training group (p<0.05) whereas there were no changes for control group. Hence, significant relationships were observed after training between plasma volume variation determined at the end of the maximal test and maximal aerobic speed (r= 0.60, p<0.05) and maximal aerobic power (r= 0.76, p<0.05) only for training group. In conclusion, seven weeks of interval training lead to a significant increase in plasma volume that possibly contributed to the observed increase of aerobic fitness (maximal aerobic power and maximal aerobic speed).
@article{Abderrahmane-2012a, author = {Abderrahmane, A B and Prioux, Jacques and Chamari, K and Ben Ounis, O and Tabka, Z and Zouhal, Hassane}, title = {Running interval training and estimated plasma volume variation.}, journal = {International Journal of Sports Physiology and Performance.}, year = {2012}, volume = {30 octobre 2012}, pages = {30 octobre 2012}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23113934} }
|2012, "Deception in Sports Using Immersive Environments", IEEE Intelligent Systems. Vol. 27(6), pp. 5-7.
@article{Brault-2012a, author = {Brault, Sébastien and Kulpa, Richard and Multon, Franck and Bideau, Benoit}, title = {Deception in Sports Using Immersive Environments}, journal = {IEEE Intelligent Systems}, year = {2012}, volume = {27}, number = {6}, pages = {5-7}, url = {http://hal.archives-ouvertes.fr/hal-00743848/} }
|2012, "Detecting Deception in Movement: The Case of the Side-Step in Rugby", PLoS ONE. Vol. 7(6), pp. e37494.
@article{Brault2012PlosOne, author = {Brault, Sébastien and Bideau, Benoit and Kulpa, Richard and Cathy Craig}, title = {Detecting Deception in Movement: The Case of the Side-Step in Rugby}, journal = {PLoS ONE}, year = {2012}, volume = {7}, number = {6}, pages = {e37494}, url = {http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037494} }
|2012, "Inhibition of Xanthine Oxidase by Allopurinol Prevents Skeletal Muscle Atrophy: Role of p38 MAPKinase and E3 Ubiquitin Ligases", Plosone. Vol. 7(10): e46668, pp. doi:10.1371.
|Abstract: Abstract Top
Alterations in muscle play an important role in common diseases and conditions. Reactive oxygen species (ROS) are generated during hindlimb unloading due, at least in part, to the activation of xanthine oxidase (XO). The major aim of this study was to determine the mechanism by which XO activation causes unloading-induced muscle atrophy in rats, and its possible prevention by allopurinol, a well-known inhibitor of this enzyme. For this purpose we studied one of the main redox sensitive signalling cascades involved in skeletal muscle atrophy i.e. p38 MAPKinase, and the expression of two well known muscle specific E3 ubiquitin ligases involved in proteolysis, the Muscle atrophy F-Box (MAFbx; also known as atrogin-1) and Muscle RING (Really Interesting New Gene) Finger-1 (MuRF-1). We found that hindlimb unloading induced a significant increase in XO activity and in the protein expression of the antioxidant enzymes CuZnSOD and Catalase in skeletal muscle. The most relevant new fact reported in this paper is that inhibition of XO with allopurinol, a drug widely used in clinical practice, prevents soleus muscle atrophy by ~20% after hindlimb unloading. This was associated with the inhibition of the p38 MAPK-MAFbx pathway. Our data suggest that XO was involved in the loss of muscle mass via the activation of the p38MAPK-MAFbx pathway in unloaded muscle atrophy. Thus, allopurinol may have clinical benefits to combat skeletal muscle atrophy in bedridden, astronauts, sarcopenic, and cachexic patients.
@article{Derbre-2012a, author = {Derbré, Fréderic and Ferrando, B and Gómez-Cabrera, MC and Sanchis-Gomar, F and Martinez-Bello, VE and Olaso-Gonzalez, G and Diaz, A and Gratas-Delamarche, Arlette and Cerda, M and Viña, José}, title = {Inhibition of Xanthine Oxidase by Allopurinol Prevents Skeletal Muscle Atrophy: Role of p38 MAPKinase and E3 Ubiquitin Ligases}, journal = {Plosone}, year = {2012}, volume = {7(10): e46668}, pages = {doi:10.1371}, url = {http://www.researchgate.net/publication/231814344_Inhibition_of_Xanthine_Oxidase_by_Allopurinol_Prevents_Skeletal_Muscle_Atrophy_Role_of_p38_MAPKinase_and_E3_Ubiquitin_Ligases} }
|2012, "Inactivity-induced oxidative stress: A central role in age-related sarcopenia?", European Journal of Sport Science. Vol. DOI:10.1080/17461391.2011.654268, pp. 1-11. Taylor & Francis.
@article{Derbre-2012b, author = {Derbré, Frédéric and Gratas-Delamarche, Arlette and Gomez-Cabrera, M.C. and Viña, José}, title = {Inactivity-induced oxidative stress: A central role in age-related sarcopenia?}, journal = {European Journal of Sport Science}, publisher = {Taylor & Francis}, year = {2012}, volume = {DOI:10.1080/17461391.2011.654268}, pages = {1-11}, url = {http://www.tandfonline.com/doi/abs/10.1080/17461391.2011.654268}, doi = {10.1080/17461391.2011.654268} }
|2012, "Energy expenditure estimate by heart rate monitor and a portable electromagnetic coils system International.", Journal of Sport Nutrition and Exercise Metabolism.. Vol. 22(2), pp. 117-130.
@article{Gastinger-2012a, author = {Gastinger, Steven and Nicolas, Guillaume and Sorel, Anthony and Sefati, H and Prioux, Jacques}, title = {Energy expenditure estimate by heart rate monitor and a portable electromagnetic coils system International.}, journal = {Journal of Sport Nutrition and Exercise Metabolism.}, year = {2012}, volume = {22(2)}, pages = {117-130}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22349175} }
|2012, "Effect of okadaic acid on cultured clam heart cells: involvement of MAPkinase pathways.", Biol Open., Dec, 2012. Vol. 1(12), pp. 1192-1199.
|Abstract: Okadaic acid (OA) is one of the main diarrhetic shellfish poisoning toxins and a potent inhibitor of protein phosphatases 1 and 2A. The downstream signal transduction pathways following the protein phosphatase inhibition are still unknown and the results of most of the previous studies are often conflicting. The aim of the present study was to evaluate the effects of OA on heart clam cells and to analyse its possible mechanisms of action by investigating the signal transduction pathways involved in OA cytotoxicity. We showed that OA at 1 µM after 24 h of treatment induces disorganization of the actin cytoskeleton, rounding and detachment of fibroblastic cells. Moreover, treatment of heart cells revealed a sequential activation of MAPK proteins depending on the OA concentration. We suggest that the duration of p38 and JNK activation is a critical factor in determining cell apoptosis in clam cardiomyocytes. In the opposite, ERK activation could be involved in cell survival. The cell death induced by OA is a MAPK modulated pathway, mediated by caspase 3-dependent mechanism. OA was found to induce no significant effect on spontaneous beating rate or inward L-type calcium current in clam cardiomyocytes, suggesting that PP1 was not inhibited even by the highest dose of OA.
@article{Hanana2012, author = {Hanana, Houda and Talarmin, Hélène and Pennec, Jean-Pierre and Droguet, Mickael and Morel, Julie and Dorange, Germaine}, title = {Effect of okadaic acid on cultured clam heart cells: involvement of MAPkinase pathways.}, journal = {Biol Open}, year = {2012}, volume = {1}, number = {12}, pages = {1192--1199}, url = {http://www.ncbi.nlm.nih.gov/pubmed/23259053}, doi = {10.1242/bio.20122170} }
|2012, "Metabolic dysfunction in late-puberty adolescent girls with type 1 diabetes: relationship to physical activity and dietary intakes.", Diabetes Metab.. Vol. 38(4), pp. 337-342..
@article{Heyman-2012a, author = {Heyman, E and Berthon, P and Youssef, H and Gratas-Delamarche, Arlette and Briard, D and Gamelin, F X and Delamarche, Paul and De Kerdanet, M}, title = {Metabolic dysfunction in late-puberty adolescent girls with type 1 diabetes: relationship to physical activity and dietary intakes.}, journal = {Diabetes Metab.}, year = {2012}, volume = {38(4)}, pages = {337-342.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22521039} }
|2012, "Oral contraception and energy intake in women: impact on substrate oxidation during exercise.", Appl Physiol Nutr Metab. 2012 Aug;37(4):646-56. Epub 2012 May 18.. Vol. 37(4), pp. (4):646-56..
@article{Isacco-2012a, author = {Isacco, L and Thivel, D and Pelle, AM and Zouhal, Hassane and Duclos, M and Duche, P and Boisseau, N}, title = {Oral contraception and energy intake in women: impact on substrate oxidation during exercise.}, journal = {Appl Physiol Nutr Metab. 2012 Aug;37(4):646-56. Epub 2012 May 18.}, year = {2012}, volume = {37(4)}, pages = {(4):646-56.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22607658} }
|2012, "Combined insulin treatment and intense exercise training improved basal cardiac function and Ca2+-cycling proteins expression in type 1 diabetic rats", Physiologie appliquée, nutrition et métabolisme. Vol. 37(1), pp. 53-62.
@article{LeDouaironLahaye-2012a, author = {Le Douairon Lahaye, Solène and Gratas-Delamarche, Arlette and Ludivine Malardé and Sami Zguira and Vincent, Sophie and Lemoine-Morel, Sophie and Carré, Francois and Rannou Bekono, Françoise}, title = {Combined insulin treatment and intense exercise training improved basal cardiac function and Ca2+-cycling proteins expression in type 1 diabetic rats}, journal = {Physiologie appliquée, nutrition et métabolisme}, year = {2012}, volume = {37(1)}, pages = {53-62}, url = {http://www.nrcresearchpress.com/doi/abs/10.1139/h11-127} }
|2012, "Combinedinsulin treatment and intense exercise training improvedcardiaccontractilefunction and Ca2+-cycling proteinsexpression in type1diabetes.", Applied Physiology Nutrition and Metabolism. Vol. 37(1), pp. 53-62.
@article{LeDouaironLahaye-2012b, author = {Le Douairon Lahaye, Solène and Gratas-Delamarche, Arlette and Malardé, Ludivine and Zguira, Sami and Vincent, Sophie and Lemoine-Morel, Sophie and Carré, Francois and Rannou Bekono, Françoise}, title = {Combinedinsulin treatment and intense exercise training improvedcardiaccontractilefunction and Ca2+-cycling proteinsexpression in type1diabetes.}, journal = {Applied Physiology Nutrition and Metabolism}, year = {2012}, volume = {37(1)}, pages = {53-62}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22185592} }
|2012, "How does the tennis serve technique influence the serve-and-volley?", journal of Sports Sciences. Vol. 30(1), pp. 1149-1156.
@article{Martin-2012a, author = {Martin, Caroline and Bideau, Benoit and Nicolas, Guillaume and Delamarche, Paul and Kulpa, Richard}, title = {How does the tennis serve technique influence the serve-and-volley?}, journal = {journal of Sports Sciences}, year = {2012}, volume = {30}, number = {1}, pages = {1149-1156}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22668422}, doi = {10.1080/02640414.2012.695079} }
|2012, "Minimal predicted distance: A common metric for collision avoidance during pairwise interactions between walkers", Gait & posture., July, 2012. Vol. 36(3)(3), pp. 399-404.
@article{Olivier-2012a, author = {Olivier, Anne-Hélène and Marin, Antoine and Crétual, Armel and Pettré, Julien}, title = {Minimal predicted distance: A common metric for collision avoidance during pairwise interactions between walkers}, journal = {Gait & posture}, year = {2012}, volume = {36(3)}, number = {3}, pages = {399-404}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22560717}, doi = {10.1016/j.gaitpost.2012.03.021} }
|2012, "Minimal predicted distance: A common metric for collision avoidance during pairwise interactions between walkers", Gait & posture. Vol. 36(3), pp. 399-404. Elsevier.
|Abstract: This study investigated collision avoidance between two walkers by focusing on the conditions that lead to avoidance manoeuvres in locomotor trajectories. Following the hypothesis of a reciprocal interaction, we suggested a mutual variable as a continuous function of the two walkers' states, denoted minimum predicted distance (MPD). This function predicts the risk of collision, and its evolution over time captures the motion adaptations performed by the walkers. By groups of two, 30 walkers were assigned locomotion tasks which lead to potential collisions. Results showed that walkers adapted their motions only when required, i.e., when MPD is too low (<1 m). We concluded that walkers are able (i) to accurately estimate their reciprocal distance at the time the crossing will occur, and (ii) to mutually adapt this distance. Furthermore, the study of MPD evolution showed three successive phases in the avoidance interaction: observation where MPD(t) is constant, reaction where MPD(t) increases to acceptable values by adapting locomotion and regulation where MPD(t) reaches a plateau and slightly decreases. This final phase demonstrates that collision avoidance is actually performed with anticipation. Future work would consist in inspecting individual motion adaptations and relating them with the variations of MPD.
@article{Olivier-2012b, author = {Olivier, Anne-Hélène and Marin, Antoine and Crétual, Armel and Pettré, Julien}, title = {Minimal predicted distance: A common metric for collision avoidance during pairwise interactions between walkers}, journal = {Gait & posture}, publisher = {Elsevier}, year = {2012}, volume = {36}, number = {3}, pages = {399--404}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22560717} }
|2012, "Effects of treadmillexercise and training frequency on anabolicsignalingpathways in the skeletal muscle of aged rats.", Experimental Gerontology. Vol. 47(1), pp. 23-28.
@article{Pasini-2012a, author = {Pasini, E and Le Douairon-Lahaye, Solène and Flati, V and Assanelli, D and Corsetti, G and Speca, S and Bernabei, R and Calvani, R and Marzetti, E}, title = {Effects of treadmillexercise and training frequency on anabolicsignalingpathways in the skeletal muscle of aged rats.}, journal = {Experimental Gerontology}, year = {2012}, volume = {47(1)}, pages = {23-28}, url = {http://www.ncbi.nlm.nih.gov/pubmed?term=Effects%20of%20treadmillexercise%20and%20training%20frequency%20on%20anabolicsignalingpathways%20in%20the%20skeletal%20muscle%20of%20aged%20rats.} }
|2012, "Effects of lactate on the voltage-gated sodium channels of rat skeletal muscle: modulating current opinion.", J Appl Physiol., May, 2012. Vol. 112(9), pp. 1454-1465.
|Abstract: During muscle contraction, lactate production and translocation across the membrane increase. While it has recently been shown that lactate anion acts on chloride channel, less is known regarding a potential effect on the voltage-gated sodium channel (Na(v)) of skeletal muscle. The electrophysiological properties of muscle Na(v) were studied in the absence and presence of lactate (10 mM) by using the macropatch-clamp method in dissociated fibers from rat peroneus longus (PL). Lactate in the external medium (petri dish + pipette) increases the maximal sodium current, while the voltage dependence of activation and fast inactivation are shifted toward the hyperpolarized potentials. Lactate induces a leftward shift in the relationship between the kinetic parameters and the imposed potentials, resulting in an earlier recruitment of muscle Na(v). In addition, lactate significantly decreases the time constant of activation at voltages more negative than -10 mV, corresponding to an acceleration of Na(v) activation. The slow inactivation process is decreased by lactate, corresponding to an enhancement in the number of excitable Na(v). In an additional series of experiments, lactate (10 mM) was only added to the petri dish, while the pipette remained sealed on the membrane area. With this approach, the electrophysiological properties of Na(v) were unaffected by lactate compared with the control condition. Altogether, these data indicate that lactate modulates muscle Na(v) properties by an extracellular pathway. These effects are consistent with an enhancement in excitability, providing new insights into the role of lactate in muscle physiology.
@article{Rannou2012, author = {Rannou, F. and Leschiera, R. and Giroux-Metges, M. A. and Pennec, J. P.}, title = {Effects of lactate on the voltage-gated sodium channels of rat skeletal muscle: modulating current opinion.}, journal = {J Appl Physiol}, year = {2012}, volume = {112}, number = {9}, pages = {1454--1465}, url = {http://dx.doi.org/10.1152/japplphysiol.00944.2011}, doi = {10.1152/japplphysiol.00944.2011} }
|2012, "Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project.", J Gerontol A Biol Sci Med Sci.. Vol. 68(1), pp. 62-67.
|Abstract: Abstract
There is no consensus regarding the definition of frailty for clinical uses.
A modified Delphi process was used to attempt to achieve consensus definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire was developed and sent to experts in the area of frailty. Responses and comments were analyzed using a pre-established strategy. Statements with an agreement more than or equal to 80% were accepted.
Overall, 44% of the statements regarding the concept of frailty and 18% of the statements regarding diagnostic criteria were accepted. There was consensus on the value of screening for frailty and about the identification of six domains of frailty for inclusion in a clinical definition, but no agreement was reached concerning a specific set of clinical/laboratory biomarkers useful for diagnosis.
There is agreement on the usefulness of defining frailty in clinical settings as well as on its main dimensions. However, additional research is needed before an operative definition of frailty can be established.
@article{Rodriguez-Manas-2012a, author = {Rodríguez-Mañas, L and Féart, C and Mann, G and Viña, J and Chatterji, S and Chodzko-Zajko,W and Gonzalez-Colaço, Harmand M and Bergman, H and Carcaillon, L and Nicholson, C and Scuteri, A and Sinclair, A and Pelaez, M and Van der Cammen, T and Beland, Fand Bickenbach, J and Delamarche, Paul and Ferrucci, L and Fried, LP and Gutiérrez-Robledo, LM and Rockwood, K and Rodríguez Artalejo, F and Serviddio, G and Vega, E and on behalf of the FOD-CC group (Appendix 1)}, title = {Searching for an Operational Definition of Frailty: A Delphi Method Based Consensus Statement. The Frailty Operative Definition-Consensus Conference Project.}, journal = {J Gerontol A Biol Sci Med Sci.}, year = {2012}, volume = {68(1)}, pages = {62-67}, url = {http://www.ncbi.nlm.nih.gov/pubmed/22511289} }
|2012, "Energy system contribution to olympic distances in flat water kayaking (500m and 1000m) in highly trained subjects.", The Journal of Strength & Conditioning Research. Vol. 26(3), pp. 825-831.
@article{Zouhal-2012a, author = {Zouhal, Hassane and Le Douairon-Lahaye, Solène and Ben Abderrahaman, A and Minter, G and Herbez, R and Castagna, C}, title = {Energy system contribution to olympic distances in flat water kayaking (500m and 1000m) in highly trained subjects.}, journal = {The Journal of Strength & Conditioning Research}, year = {2012}, volume = {26(3)}, pages = {825-831}, url = {http://www.ncbi.nlm.nih.gov/pubmed?term=Energy%20system%20contribution%20to%20olympic%20distances%20in%20flat%20water%20kayaking%20%28500m%20and%201000m%29%20in%20highly%20trained%20subjects.} }
|2011, "Fall detection with multiple cameras: an occlusion-resistant method based on 3-D silhouette vertical distribution", IEEE Trans Inf Technol Biomed.. Vol. 15(2)(2), pp. 290-300.
|Abstract: According to the demographic evolution in industrialized countries, more and more elderly people will experience falls at home and will require emergency services. The main problem comes from fall-prone elderly living alone at home. To resolve this lack of safety, we propose a new method to detect falls at home, based on a multiple cameras network for reconstructing the 3D shape of people. Fall events are detected by analyzing the volume distribution along the vertical axis, and an alarm is triggered when the major part of this distribution is abnormally near the ¬'oor during a prede¬�ned period of time, which implies that a person has fallen on the ¬'oor. This method was validated with 24 realistic scenarios showing 22 fall events and 24 cofounding events (11 crouching position, 9 sitting position, 4 lying on a sofa position) under several camera con¬�gurations and achieved 99.7% sensitivity and speci¬�city or better with 4 cameras or more. A real-time implementation using GPU reached 10 frames per second (fps) with 8 cameras and 16 fps with 3 cameras.
@article{Auvinet-2011a, author = {Auvinet, Edouard and Multon, Franck and Saint-Arnaud, Alain and Rousseau, Jacqueline and Meunier, Jean}, title = {Fall detection with multiple cameras: an occlusion-resistant method based on 3-D silhouette vertical distribution}, journal = {IEEE Trans Inf Technol Biomed.}, year = {2011}, volume = {15(2)}, number = {2}, pages = {290-300}, url = {http://www.ncbi.nlm.nih.gov/pubmed/?term=Fall+detection+with+multiple+cameras%3A+Accountingn+occlusion-resistant+method+based+on+3D+silhouette+vertical+distribution}, doi = {10.1109/TITB.2010.2087385} }
|2011, "Effect of an individualized physical training program on cortisol and growth hormone levels in obese children.", Ann. Endocrinol.. Vol. 72(1), pp. 34-41.
@article{BenOunis-2011a, author = {Ben Ounis, O and Elloumi, M and Zouhal, Hassane and Makni, E and Zaouali, M and Lac, G. and Tabka, Z and Amri, M}, title = {Effect of an individualized physical training program on cortisol and growth hormone levels in obese children.}, journal = {Ann. Endocrinol.}, year = {2011}, volume = {72(1)}, pages = {34-41}, url = {http://www.ncbi.nlm.nih.gov/pubmed?term=Effect%20of%20an%20individualized%20physical%20training%20program%20on%20cortisol%20and%20growth%20hormone%20levels%20in%20obese%20children.} }
|2011, "MAP kinase cell signaling pathway as biomarker of environmental pollution in the sponge Suberites domuncula.", Ecotoxicology., Nov, 2011. Vol. 20(8), pp. 1727-1740.
|Abstract: In the present study, we analyzed the effects of two major pollutants of the environment, tributyltin (TBT) and water-accommodated fraction (WAF) of diesel oil, on MAP kinase activation, apoptosis induction and DNA damage, in the marine sponge Suberites domuncula. Our results clearly demonstrated a differential activation of the MAPKs depending on the chemicals tested. TBT induced the activation of p38 and JNK while diesel oil enhanced activation of both ERK and p38. The activation of MAPKs was observed after 1 h exposure and 6 and 24 h of recovery in seawater. In addition, DNA fragmentation, assessed by two techniques, the Fast micromethod(®) and the TUNEL assay, was detected after sponges were treated with both chemicals. Moreover, the study of caspase 3/7 activity showed that apoptosis was induced and triggered with all concentrations of TBT but only at high diesel oil concentrations. After TBT exposure, a correlation was observed between JNK activation, caspase 3 activity and DNA damage while p38 activation followed the two latter parameters at high concentrations of diesel oil, suggesting that sponges enhanced a specific apoptotic pathway depending on the xenobiotic tested. This study demonstrated a high signal response by the sponge Suberites domuncula to the tested chemicals. Cell signaling pathway studies may thus be of use in water quality biomonitoring programs.
@article{Chatel2011, author = {Châtel, A. and Talarmin, H. and Hamer, B. and Schröder, H. C. and Müller, W E G. and Dorange, G.}, title = {MAP kinase cell signaling pathway as biomarker of environmental pollution in the sponge Suberites domuncula.}, journal = {Ecotoxicology}, year = {2011}, volume = {20}, number = {8}, pages = {1727--1740}, url = {http://dx.doi.org/10.1007/s10646-011-0706-1}, doi = {10.1007/s10646-011-0706-1} }
|2011, "Induction of apoptosis in mussel Mytilus galloprovincialis gills by model cytotoxic agents.", Ecotoxicology., Nov, 2011. Vol. 20(8), pp. 2030-2041.
|Abstract: Apoptosis signaling pathway was investigated in the marine mussel Mytilus galloprovincialis exposed to various stressors. Analyses were performed in mussels exposed to two major pollutants of the aquatic environment: tributyltin and the water soluble fraction of diesel oil, for 1 h and animals were then maintained in sea water for a recovery period of 6 and 24 h. Apoptosis was evaluated at several levels of the cell signaling cascade by measuring Bcl-xS expression, caspase-3 activity and DNA damage (Fast micromethod(®) and TUNEL techniques). H(2)O(2) was used as a control of apoptosis induction for validation of the assays. Results showed an induction of Bcl-xS expression, a protein implicated in apoptosis, after 1 h exposure to all concentrations of chemicals. Moreover, in the same manner, apoptotic DNA damage was induced with all chemicals tested. Besides, caspase 3 activity was detected after 1 h exposure to low doses of TBT and diesel oil while the high concentrations induced this protein after 6 h. The achieved data were also correlated with our previous study, demonstrating an induction of the mitogen-activated protein kinase (MAPK) activity in the mussel M. galloprovincialis exposed to the same conditions. In conclusion, this study was one of the first characterizing the MAP kinase cell signaling pathway leading to apoptosis in the mussel M. galloprovincialis exposed to chemicals. It showed for the first time that the Bcl-xS protein was present in these mussels as in other species and played a role in apoptosis mediation. Moreover, the main originality of this work was that it showed that two apoptotic pathways might be present in the mussel: a caspase 3-dependent and a caspase 3-independent pathways.
@article{Chatel2011a, author = {Châtel, A. and Hamer, B. and Jakšić, Z. and Vucelić, V. and Talarmin, H. and Dorange, G. and Schröder, H. C. and Müller, W E G.}, title = {Induction of apoptosis in mussel Mytilus galloprovincialis gills by model cytotoxic agents.}, journal = {Ecotoxicology}, year = {2011}, volume = {20}, number = {8}, pages = {2030--2041}, url = {http://dx.doi.org/10.1007/s10646-011-0746-6}, doi = {10.1007/s10646-011-0746-6} }
|2011, "Additional energetic cost due to belt speed variations when walking on a treadmill", Journal of Electromyography and Kinesiology. Vol. 21(3), pp. 551-556. Elsevier.
|Abstract: Background
Treadmill is commonly used in routine evaluation of walking capacities, especially when dealing with energetic cost, as it allows to measure this motion on a long enough period. However, even when using powerful treadmills, it is impossible to avoid belt speed variations. The objective of this paper was to demonstrate that this instantaneous treadmill speed has to be taken into account in mechanical work calculation during treadmill walking.
To do so, 11 healthy subjects participated in the study. They walked on treadmill at four different speeds: very slow View the MathML source(0.3ms-1), slow View the MathML source(0.8ms-1), normal View the MathML source(1.4ms-1) and fast View the MathML source(1.9ms-1). To compute PViPVi, the instantaneous mechanical work relatively to the instantaneous treadmill speed, we applied the work-energy theorem in a non-inertial reference frame induced by the treadmill speed variations. This value was then compared to View the MathML sourcePV¯, i.e. the instantaneous mechanical work computed with the usual approximation of a constant treadmill speed.
The speed variations had an average value of 17% for the very slow speed and around 4.5% for the three other and more usual speeds. These variations have a strong influence on instantaneous mechanical work. Indeed, View the MathML sourcePV¯ is nearly null when not considering speed variations whereas PViPVi goes up to View the MathML source113mWkg-1 at higher speeds.
To conclude, our work showed that the instantaneous treadmill speed has to be taken into account in mechanical work computation. This method may provide supplementary information in clinical assessments and analyses of gait. Indeed, when using the same methodology on formerly acquired data in a group of 13 hemiplegic patients, we found that if View the MathML sourcePV¯ is not null in this impaired subjects group, PViPVi is still 30% higher.
@article{Cretual-2011a, author = {Crétual, A and Fusco, Nicolas}, title = {Additional energetic cost due to belt speed variations when walking on a treadmill}, journal = {Journal of Electromyography and Kinesiology}, publisher = {Elsevier}, year = {2011}, volume = {21}, number = {3}, pages = {551--556}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21435905} }
|2011, "Ceramide in chemotherapy of tumors.", Recent Pat Anticancer Drug Discov.. Vol. 6(3), pp. 284-93..
|Abstract: It is well known that tumor formation arises from the imbalance between cell death and proliferation. For many years, cancer research has engaged an important part of its efforts to find new therapeutic strategies based on cell death induction. One of the predominant ways to kill tumor cells is to trigger apoptosis by chemotherapy. However tumor responsiveness to chemotherapy is dependent on different biological factors including cancer types, genetics and pharmacogenetics. Although molecular mechanisms involved in chemotherapy-induced apoptosis are diverse and depend on cell-type and drugs used, a common pathway leading to tumor cell death has been shown to implicate the generation of a simple cellular sphingolipid, ceramide. Ceramide is released by the activity of neutral or acidic sphingomyelinases or de novo synthesis during treatment with chemotherapy. This review in particular focuses on enzymes involved in chemotherapy-induced cell death such as neutral or acidic sphingomyelinases and ceramide synthases, the role of ceramide in cellular effects of chemotherapy at the plasma membrane or the mitochondria and the induction of cell death by ceramide. It also includes recent advances on novel patented sphingolipid compounds and cancer therapeutic strategies based on ceramide release.
@article{DimancheBoitrel-2011, author = {Dimanche-Boitrel, Marie-Thérèse and Rebillard, Amelie and Gulbins, E}, title = {Ceramide in chemotherapy of tumors.}, journal = {Recent Pat Anticancer Drug Discov.}, year = {2011}, volume = {6(3)}, pages = {284-93.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21762073}, doi = {10.2174/157489211796957838} }
|2011, "A new method to estimate energy expenditure from abdominal and rib cage distances.", Eur J Appl Physiol.. Vol. 111, pp. 2823-2835.
@article{Gastinger-2011a, author = {Gastinger, Steven and Sefati, H and Nicolas, Guillaume and Sorel, Anthony and Gratas-Delamarche, Arlette and Prioux, Jacques}, title = {A new method to estimate energy expenditure from abdominal and rib cage distances.}, journal = {Eur J Appl Physiol.}, year = {2011}, volume = {111}, pages = {2823-2835}, url = {http://www.ncbi.nlm.nih.gov/pubmed?term=A%20new%20method%20to%20estimate%20energy%20expenditure%20from%20abdominal%20and%20rib%20cage%20distances.} }
|2011, "Catecholamine Response To Exercise In Obese, Overweight And Lean Adolescent Boys.", Medicine Science and Sports Exercise. Vol. 43(3), pp. 408-415.
@article{Georges-2011a, author = {Jabbour Georges and Lemoine-Morel, Sophie and Casatza Gretchen and Yousse Hala and Moussa Elie and Zouhal, Hassane}, title = {Catecholamine Response To Exercise In Obese, Overweight And Lean Adolescent Boys.}, journal = {Medicine Science and Sports Exercise}, year = {2011}, volume = {43(3)}, pages = {408-415}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20689461} }
|2011, "TNFα increases resting potential in isolated fibres from rat peroneus longus by a PKC mediated mechanism: involvement in ICU acquired polyneuromyopathy.", Cytokine., Nov, 2011. Vol. 56(2), pp. 149-152.
|Abstract: Our aim was to investigate the effect of TNFα on muscle resting potential (RP) and then in muscle excitability and to demonstrate another mechanism implicated in intensive care units (ICU) acquired polyneuromyopathy.Experiments were carried out on adult female Wistar rats. After isolation of muscle fibres from peroneus longus, influence of TNFα was tested on RP by using intracellular microelectrodes. Digoxin and chelerythrin were used to determine the mechanism of TNFα action.First, we found that TNFα induced a concentration dependent increase of muscle RP and that this mechanism, which was blocked by digoxin, was due to an effect on the Na/K ATPase. As it was also blocked by chelerythrin it was concluded that this effect was mediated by PKC activation of the Na/K ATPase.We demonstrated that TNFα leads to a PKC mediated increase in muscle RP. Depolarization needed to reach the threshold voltage for muscle action potential should then be higher and this could be involved in the decrease in muscle excitability observed in acquired polyneuromyopathy.
@article{Guillouet2011, author = {Guillouet, Maité and Gueret, Gildas and Rannou, Fabrice and Giroux-Metges, Marie-Agnès and Gioux, Maxime and Arvieux, Charles C. and Pennec, Jean-Pierre}, title = {TNFα increases resting potential in isolated fibres from rat peroneus longus by a PKC mediated mechanism: involvement in ICU acquired polyneuromyopathy.}, journal = {Cytokine}, year = {2011}, volume = {56}, number = {2}, pages = {149--152}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21737299}, doi = {10.1016/j.cyto.2011.05.023} }
|2011, "Tumor necrosis factor-α downregulates sodium current in skeletal muscle by protein kinase C activation: involvement in critical illness polyneuromyopathy.", Am J Physiol Cell Physiol., Nov, 2011. Vol. 301(5), pp. C1057-C1063.
|Abstract: Sepsis is involved in the decrease of membrane excitability of skeletal muscle, leading to polyneuromyopathy. This effect is mediated by alterations of the properties of voltage-gated sodium channels (Na(V)), but the exact mechanism is still unknown. The aim of the present study was to check whether tumor necrosis factor (TNF-α), a cytokine released during sepsis, exerts a rapid effect on Na(V). Sodium current (I(Na)) was recorded by macropatch clamp in skeletal muscle fibers isolated from rat peroneus longus muscle, in control conditions and after TNF-α addition. Analyses of dose-effect and time-effect relationships were carried out. Effect of chelerythrine, a PKC inhibitor, was also studied to determine the way of action of TNF-α. TNF-α induced a reversible dose- and time-dependent inhibition of I(Na). A maximum inhibition of 75% of the control current was observed. A shift toward more negative potentials of activation and inactivation curves of I(Na) was also noticed. These effects were prevented by chelerythrine pretreatment. TNF-α is a cytokine released in the early stages of sepsis. Besides a possible transcriptional role, i.e., modification of the channel type and/or number, we demonstrated the existence of a rapid, posttranscriptional inhibition of Na(V) by TNF-α. The downregulation of the sodium current could be mediated by a PKC-induced phosphorylation of the sodium channel, thus leading to a significant decrease in muscle excitability.
@article{Guillouet2011a, author = {Guillouet, Maité and Gueret, Gildas and Rannou, Fabrice and Giroux-Metges, Marie-Agnès and Gioux, Maxime and Arvieux, Charles C. and Pennec, Jean-Pierre}, title = {Tumor necrosis factor-α downregulates sodium current in skeletal muscle by protein kinase C activation: involvement in critical illness polyneuromyopathy.}, journal = {Am J Physiol Cell Physiol}, year = {2011}, volume = {301}, number = {5}, pages = {C1057--C1063}, url = {http://dx.doi.org/10.1152/ajpcell.00097.2011}, doi = {10.1152/ajpcell.00097.2011} }
|2011, "Establishment of functional primary cultures of heart cells from the clam Ruditapes decussatus.", Cytotechnology., May, 2011. Vol. 63(3), pp. 295-305.
|Abstract: Heart cells from the clam Ruditapes decussatus were routinely cultured with a high level of reproducibility in sea water based medium. Three cell types attached to the plastic after 2 days and could be maintained in vitro for at least 1 month: epithelial-like cells, round cells and fibroblastic cells. Fibroblastic cells were identified as functional cardiomyocytes due to their spontaneous beating, their ultrastructural characteristics and their reactivity with antibodies against sarcomeric α-actinin, sarcomeric tropomyosin, myosin and troponin T-C. Patch clamp measurements allowed the identification of ionic currents characteristic of cardiomyocytes: a delayed potassium current (I (K slow)) strongly suppressed (95 by tetraethylammonium (1 mM), a fast inactivating potassium current (I (K fast)) inhibited (50 by 4 amino-pyridine at 1 mM and, at a lower level (34 by TEA, a calcium dependent potassium current (I (KCa)) activated by strong depolarization. Three inward voltage activated currents were also characterized in some cardiomyocytes: L-type calcium current (I (Ca)) inhibited by verapamil at 5 × 10(-4) M, T-type Ca(2+) current, rapidly activated and inactivated, and sodium current (I (Na)) observed in only a few cells after strong hyperpolarization. These two currents did not seem to be physiologically essential in the initiation of the beatings of cardiomyocytes. Potassium currents were partially inhibited by tributyltin (TBT) (1 μM) but not by okadaic acid (two marine pollutants). DNA synthesis was also demonstrated in few cultured cells using BrdU (bromo-2'-deoxyuridine). Observed effects of okadaic acid and TBT demonstrated that cultured heart cells from clam Ruditapes decussatus can be used as an experimental model in marine toxicology.
@article{Hanana2011, author = {Hanana, H. and Talarmin, H. and Pennec, J. P. and Droguet, M. and Gobin, E. and Marcorelle, P. and Dorange, G.}, title = {Establishment of functional primary cultures of heart cells from the clam Ruditapes decussatus.}, journal = {Cytotechnology}, year = {2011}, volume = {63}, number = {3}, pages = {295--305}, url = {http://dx.doi.org/10.1007/s10616-011-9347-8}, doi = {10.1007/s10616-011-9347-8} }
|2011, "Imperceptible Relaxation of Collision Avoidance Constraints in Virtual Crowds", ACM Transaction on Graphics. Vol. 30(6)(6), pp. 138:1-138:10.
|Abstract: he performance of an interactive virtual crowd system for entertainment purposes can be greatly improved by setting a level-of-details (LOD) strategy: in distant areas, collision avoidance can even be stealthy disabled to drastically speed-up simulation and to handle huge crowds. The greatest difficulty is then to select LODs to progressively simplify simulation in an imperceptible but efficient manner. The main objective of this work is to experimentally evaluate spectators' ability to detect the presence of collisions in simulations. Factors related to the conditions of observation and simulation are studied, such as the camera angles, distance to camera, level of interpenetration or crowd density. Our main contribution is to provide a LOD selection function resulting from two perceptual studies allowing crowd system designers to scale a simulation by relaxing the collision avoidance constraint in a least perceptible manner. The relaxation of this constraint is an important source for computational resources savings. Our results reveal several misconceptions in previously used LOD selection functions and suggest yet unexplored variables to be considered. We demonstrate our function efficiency over several evaluation scenarios.
@article{Kulpa-2011a, author = {Richard Kulpa and Anne-Hélène Olivier and Jan Ondrej and Julien Pettré}, title = {Imperceptible Relaxation of Collision Avoidance Constraints in Virtual Crowds}, journal = {ACM Transaction on Graphics}, year = {2011}, volume = {30(6)}, number = {6}, pages = {138:1-138:10}, url = {http://dl.acm.org/citation.cfm?id=2024172} }
|2011, "Effects of exercise training combined with insulin treatment on cardiac NOS1 signaling pathways in type 1 diabetic rats.", Mol Cell Biochem.. Vol. 347(1-2), pp. 53-62.
@article{LeDouaironLahaye-2011a, author = {Le Douairon Lahaye, Solène and Rebillard, Amélie and Zguira, Med Sami and Malardé, Ludivine and Saïag, Bernard and Gratas-Delamarche, Arlette and Carré, Francois and Rannou Bekono, Françoise}, title = {Effects of exercise training combined with insulin treatment on cardiac NOS1 signaling pathways in type 1 diabetic rats.}, journal = {Mol Cell Biochem.}, year = {2011}, volume = {347(1-2)}, pages = {53-62}, url = {http://www.researchgate.net/publication/47385472_Effects_of_exercise_training_combined_with_insulin_treatment_on_cardiac_NOS1_signaling_pathways_in_type_1_diabetic_rats} }
|2011, "A Motion-based User Interface for the Control of Virtual Humans Performing Sports", International Journal of Virtual Reality. Vol. 10(3)(3), pp. 1-8.
@article{Liang-2011a, author = {Xiubo Liang and Zheng Wang and Weidong Geng and Franck Multon}, title = {A Motion-based User Interface for the Control of Virtual Humans Performing Sports}, journal = {International Journal of Virtual Reality}, year = {2011}, volume = {10(3)}, number = {3}, pages = {1-8}, url = {http://connection.ebscohost.com/c/articles/74422178/motion-based-user-interface-control-virtual-humans-performing-sports} }
|2011, "A step-by-step modeling, analysis and annotation of locomotion", Computer Animation and Virtual Worlds. Vol. 22 (5), pp. 421–433.
|Abstract: Annotating unlabeled motion captures plays an important role in Computer Animation for motion analysis and motion edition purposes. Locomotion is a difficult case study as all the limbs of the human body are involved whereas a low-dimensional global motion is performed. The oscillatory nature of the locomotion makes difficult the distinction between straight steps and turning ones, especially for subtle orientation changes. In this paper we propose to geometrically model the center of mass trajectory during locomotion as a Cequation image-continuous circular arcs sequence. Our model accurately analyzes the global motion into the velocity-curvature space. An experimental study demonstrates that an invariant law links curvature and velocity during straight walk. We finally illustrate how the resulting law can be used for annotation purposes: any unlabeled motion captured walk can be transformed into an annotated sequence of straight and turning steps. Several examples demonstrate the robustness of our approach and give comparison with classical threshold-based techniques. Copyright © 2011 John Wiley & Sons, Ltd.
@article{Olivier-2011a, author = {Anne-Hélène Olivier and Richard Kulpa and Julien Pettré and Armel Crétual}, title = {A step-by-step modeling, analysis and annotation of locomotion}, journal = {Computer Animation and Virtual Worlds}, year = {2011}, volume = {22 (5)}, pages = {421–433}, url = {http://onlinelibrary.wiley.com/doi/10.1002/cav.377/abstract?systemMessage=Wiley+Online+Library+will+be+disrupted+on+31+August+from+10%3A00-12%3A00+BST+%2805%3A00-07%3A00+EDT%29+for+essential+maintenance} }
|2011, "Na v1.4 and Na v1.5 are modulated differently during muscle immobilization and contractile phenotype conversion.", J Appl Physiol., Aug, 2011. Vol. 111(2), pp. 495-507.
|Abstract: Muscle immobilization leads to modification in its fast/slow contractile phenotype. Since the properties of voltage-gated sodium channels (Na(v)) are different between "fast" and "slow" muscles, we studied the effects of immobilization on the contractile properties and the Na(v) of rat peroneus longus (PL). The distal tendon of PL was cut and fixed to the adjacent bone at neutral muscle length. After 4 or 8 wk of immobilization, the contractile and the Na(v) properties were studied and compared with muscles from control animals (Student's t-test). After 4 wk of immobilization, PL showed a faster phenotype with a rightward shift of the force-frequency curve and a decrease in both the Burke's index of fatigability and the tetanus-to-twitch ratio. These parameters showed opposite changes between 4 and 8 wk of immobilization. The maximal sodium current in 4-wk immobilized fibers was higher compared with that of control fibers (11.5 ± 1.2 vs. 7.8 ± 0.8 nA, P = 0.008), with partial recovery to the control values in 8-wk immobilized fibers (8.6 ± 0.7 nA, P = 0.48). In the presence of tetrodotoxin, the maximal residual sodium current decreased continuously throughout immobilization. Using the Western blot analysis, Na(v)1.4 expression showed a transient increase in 4-wk muscle, whereas Na(v)1.5 expression decreased during immobilization. Our results indicate that a muscle immobilized at optimal functional length with the preservation of neural inputs exhibits a transient fast phenotype conversion. Na(v)1.4 expression and current are related to the contractile phenotype variation.
@article{Rannou2011, author = {Rannou, Fabrice and Pennec, Jean-Pierre and Morel, Julie and Guéret, Gildas and Leschiera, Raphaël and Droguet, Mickaël and Gioux, Maxime and Giroux-Metges, Marie-Agnès}, title = {Na v1.4 and Na v1.5 are modulated differently during muscle immobilization and contractile phenotype conversion.}, journal = {J Appl Physiol}, year = {2011}, volume = {111}, number = {2}, pages = {495--507}, url = {http://dx.doi.org/10.1152/japplphysiol.01136.2010}, doi = {10.1152/japplphysiol.01136.2010} }
|2011, "Rapid hemodilution induced by desmopressin after erythropoietin administration in humans", Journal of human sport & exercise. Vol. 6(2), pp. 1-8. Universidad de Alicante. Área de Educación Fisica y Deporte.
|Abstract: We have shown that treatment with demospressin has a very effective hemodilution effect in healthy humans. These results led us to suggest the possible role of desmopressin to mask blood doping in sports. Based on our results, the World Anti-Doping Agency included the desmopressin in the 2011 List of Prohibited Substances and Methods. On this occasion, the aim of our study was to test the desmopressin-induced hemodilution after rHuEpo administration in humans. This was an intra-subject, crossover study in which five physically active male acted as their own controls. On their first visit to the laboratory a basal blood sample was taken. The next day, the subjects began the treatments. They received a subcutaneous rHuEpo injection three times/week for a two weeks period. On the second visit to the laboratory, seventeen days after, a blood sample was taken. Thereafter, the subjects received an oral dose of 4.3 μg/kg of desmopressin and were instructed to ingest 1.5 liters of mineral water during the following fifteen minutes. Three hours after the water ingestion a second blood sample was obtained. The samples were analyzed for hematocrit (Hct), hemoglobin (Hb), reticulocytes (Ret%) and OFF Hr-Score. We found significantly higher Hct, Hb and Ret% levels after rHuEpo administration. Administration of desmopressin significantly decreased the Hct and Hb values but we did not find significant changes in Ret%. The values of the OFF Hr-Score also decreased after treatment with desmopressin. Desmopressin has a very effective hemodilution effect after rHuEpo administration and significantly modifies the hematological values measured by the anti-doping authorities to detect blood doping. We consider that these results reinforce the conclusions reported in our first study and confirm that desmopressin is a very effective masking agent for blood doping.
@article{SanchisGomar-2011a, author = {Sanchis Gomar, F and Martinez Bello, VE and Derbré, Frédéric and Garcia Lopez, E and Garcia Valles, R and Brioche, Thomas and Ferrando, B and Ibañez Sania, S and Pareja Galeano, H and Gomez Cabrera, MC and Viña, J}, title = {Rapid hemodilution induced by desmopressin after erythropoietin administration in humans}, journal = {Journal of human sport & exercise}, publisher = {Universidad de Alicante. Área de Educación Fisica y Deporte}, year = {2011}, volume = {6}, number = {2}, pages = {1-8}, url = {http://www.jhse.ua.es/index.php/jhse/article/viewArticle/225}, doi = {10.4100/jhse.2011.62.12} }
|2011, "Judging the 'passability' of dynamic gaps in a virtual rugby environment.", Human Movement Science. Vol. 30(5), pp. 942-956 doi: 10.1016/j.humov.2010.08.004. Epub 2010 Oct 16..
|Abstract: Affordances have recently been proposed as a guiding principle in perception-action research in sport (Fajen, Riley, & Turvey, 2009). In the present study, perception of the 'passability' affordance of a gap between two approaching defenders in rugby is explored. A simplified rugby gap closure scenario was created using immersive, interactive virtual reality technology where 14 novice participants (attacker) judged the passability of the gap between two virtual defenders via a perceptual judgment (button press) task. The scenario was modeled according to tau theory (Lee, 1976) and a psychophysical function was fitted to the response data. Results revealed that a tau-based informational quantity could account for 82% of the variance in the data. Findings suggest that the passability affordance in this case, is defined by this variable and participants were able to use it in order to inform prospective judgments as to passability. These findings contribute to our understanding of affordances and how they may be defined in this particular sporting scenario; however, some limitations regarding methodology, such as decoupling perception and action are also acknowledged.
@article{Watson-2011, author = {Gareth Watson and Brault, Sébastien and Kulpa, Richard and Bideau, Benoit and Joe Butterfield and Cathy Craig}, title = {Judging the 'passability' of dynamic gaps in a virtual rugby environment.}, journal = {Human Movement Science}, year = {2011}, volume = {30(5)}, pages = {942-956 doi: 10.1016/j.humov.2010.08.004. Epub 2010 Oct 16.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20952081}, doi = {10.1016/j.humov.2010.08.004} }
|2011, "Assessing and training standing balance in older adults: a novel approach using the Nintendo Wii' Balance Board", Gait & Posture. Vol. 33(2), pp. 303-305.
@article{Young-2011, author = {William Young and Stuart Ferguson and Brault, Sébastien and Cathy Craig}, title = {Assessing and training standing balance in older adults: a novel approach using the Nintendo Wii' Balance Board}, journal = {Gait & Posture}, year = {2011}, volume = {33(2)}, pages = {303-305}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21087865}, doi = {10.1016/j.gaitpost.2010.10.089} }
|2011, "Inverse relationship between % weight change and finishing time in 643 42km marathon runners.", Br J Sports Med. Vol. 45(14), pp. 1101-1105.
@article{Zouhal-2011, author = {Zouhal, Hassane and Groussard, Carole and Minter, Guenolé and Vincent, Sophie and Crétual, Armel and , Gratas-Delamarche, Arlette and Delamarche, Paul and Noakes Timothy David}, title = {Inverse relationship between % weight change and finishing time in 643 42km marathon runners.}, journal = {Br J Sports Med}, year = {2011}, volume = {45(14)}, pages = {1101-1105}, url = {http://www.ncbi.nlm.nih.gov/pubmed?term=Inverse%20relationship%20between%20%25%20weight%20change%20and%20finishing%20time%20in%20643%2042km%20marathon%20runners.}, doi = {10.1136/bjsm.2010.074641} }
|2011, "Inverse relationship between percentage body weight change and finishing time in 643 forty-two-kilometre marathon runners", British Journal of Sports Medicine. Vol. 45, pp. 1101-1105 doi:10.1136/bjsm.2010.074641.
@article{Zouhal-2011a, author = {Zouhal, Hassane and Groussard, Carole and Guenolé Minter and Vincent, Sophie and Armel Crétual and Gratas-Delamarche, Arlette and Delamarche, Paul and Timothy David Noakes}, title = {Inverse relationship between percentage body weight change and finishing time in 643 forty-two-kilometre marathon runners}, journal = {British Journal of Sports Medicine}, year = {2011}, volume = {45}, pages = {1101-1105


text:
An Orange County man has been charged with child neglect after deputies say he left a 2-year-old boy alone in an apartment for over an hour.
Franklin Capellan, 22, was arrested on Tuesday after a maintenance worker found the child unattended inside of an apartment at the Village Townhomes, according to a report.
Deputies said the maintenance worker was hired to fix items inside of the apartment and heard a child crying from an upstairs apartment.
The child was found in a bedroom described as "messy" with nothing to drink, deputies said. In the bedroom next to where the child was found, deputies said they found several smoked marijuana blunts and a glass pipe.
Capellan told deputies that he had left the child with a man named "Tony" and went to the gas station. Deputies couldn't locate a man named Tony.
Deputies said Capellan then stopped cooperating with officers and refused to sign his statement.
Capellan was taken to Orange County Jail at 11:30 a.m. on $1,000 bond.

subset: commoncrawl


text:
Terrel Castille sets up a variety of melons at a past Opelousas Farmers Market. The Farmers Market is open on Tuesdays, Thursdays Saturdays.
- Filed Under
Le Cajun Cafe. 9-10 a.m. Du cafe et du discutation, tout en francais.(Coffee and casual conversational Cajun French - no English allowed). Hosted by the Cajun Prairie Chapter of OLLI at LSU-Eunice. LSUE Community Education Building, 2048 Johnson Highway, Eunice. (337) 550-1390.
"Matilda and The Dreamtime." 10:30-11:15 a.m. Australian storyteller and musician Paul Taylor will introduce children to the multifaceted cultures of Australia through the tale of Matilda. The performance includes songs, poetry, dance and a didgeridoo. North Regional Library, 5101 N. University Ave., Carencro. (337) 896-6323.
Pandemonium Theater Group presents "The Little Mermaid." 7 p.m. Pandemonium Theater Group presents its production of "The Little Mermaid" as written by Wayne R. Scott and produced with special arrangements with LifeHouse Productions, Inc. based on the story of Hans Christian Andersen. Tickets are $10 for students and $12 for adults. Tickets can be purchased online at thegrandoperahouse.org, by calling the Grand Opera House at (337) 785-0440 or at the door one hour prior to show time. The Grand Opera House of the South, 525 North Parkerson Ave., Crowley. (337) 785-0440.
"The Glass Mendacity: A Comedy in Two Acts." 7:30-9:30 p.m. The Delta Grand Theatre presents "The Glass Mendacity," a send-up of the works of Tennessee Williams. The big, brawling characters that populate Williams' finest works - "The Glass Menagerie," "Cat on a Hot Tin Roof" and "A Streetcar Named Desire" - are mixed and matched in new ways, then sent through the comic wringer of a plot that mixes madness, alcoholism, deceit and fantasy. The Delta Grand Theatre, 120 S. Market St., Opelousas. $10. (337) 407-1806.
Branch Playboys. 6:30 p.m. Prejean's Restaurant, 3480 NE Evangeline Thruway, Lafayette. (337) 896-3247. prejeans.com.
Eunice Farmers Market. 8 a.m. Choose from seasonal garden vegetables, fruits, jellies, sweet dough pies, honey, breads and other locally made products. Arts and crafts may appear from time to time as vendors are available. Eunice Farmers Market, corner of Second Street and Park Avenue, 201 Park Ave., Eunice. (337) 457-6503.
Farmers Market in Opelousas. 6:30 a.m. Three market mornings per week means three chances to find homegrown fruits, vegetables, preserves, jellies and more. St. Landry Market, 925 E. Landry St., Opelousas. (337) 543-6626.
Randy Young & Lonesome Drifters. 8:30 p.m. Lakeview Park, 1717 Highway 13, Eunice. (337) 457-2881.
Rendez-Vous Des Cajuns presents Johnny Sonnier & Cajun Heritage. 6-7:30 p.m. Liberty Theater, 200 W. Park Ave., Eunice. (337) 457-7389.
Swamp Blue. 8 p.m. Beau's Garage, 125 N. Court St., Opelousas. (337) 678-0807.
Contra and Square Dance. 3-5:30 p.m. The Laughin Lizards band (Steve and Donna Bing, Liz Hampton, Mick Billingsley) will bring the tunes to NUNU's Contra and Square Dance. Beginners are welcome, no partner necessary and all dances are called. Callers are Charlene Heaton, Kendall Rogers and Steve Bing. Food and refreshments will be available for purchase. NUNU's Arts and Culture Collective, 1510 Bayou Courtableau Road, Arnaudville. $5. (337) 453-3307.
Creole Culture Day. 10 a.m. to 5 p.m. This year's Creole Culture Day will focus on family folklore and the activities planned for the day will include: storytelling, Creole exhibits, cooking demonstrations, kids games and crafts, sharing circles on Creole music and traditional healing, boat tours and canoeing, music in the Performance Center by Gerard Delafose & The Zydeco Gators as well as Corey & The Zydeco Hot Peppers plus a Creole Jam in the village led by Brandon Ledet. Vermilionville and C.R.E.O.L.E., Inc. are also partnering with United Blood Services to have a blood drive onsite from 10 a.m. to 2 p.m. Vermilionville, 300 Fisher Road, Lafayette. (337) 233-4077.
Jim Gaspard & Scott Rambler. 11:30 a.m. to 1:30 p.m. Prejean's Restaurant, 3480 NE Evangeline Thruway, Lafayette. (337) 896-3247.
Paddle The Waters of Lake Chicot. 2 p.m. This adventure will take a loop route that will tour some of the most beautiful portions of the lake, then return to the departure point for a picnic supper (provided). It's a great next step to discovering another place to paddle. Pack and Paddle, 601 E. Pinhook Road, Lafayette. $40 per person - reservations required. (337) 232-5854.
Charles Ventre. 8 p.m. Beau's Garage, 125 N. Court St., Opelousas. (337) 678-0807.


text:
|Legal Aid
|HVS 5b
|3 pitches. From SDD guide: "Right to left girdle of the cliff. Start R of Trembling Wall, below a crack which runs up L of a cruddy groove.
1. 40'. 5a. Gain the crack, which is climbed to a bulge. Traverse LWs across the wall to the dead tree on Trembling Wall.
2. 40'. 5b. Climb to a break in the overhang and go through this to a line which leads left across the wall. Traverse delicately [up and] across to the flake on Hostile Witness, then move up and swing around the corner to a belay in Oak Tree Zig Zag [this basically reverses the crux of Suspended Sentence].
3. 35'. 4a. Follow the obvious line left to join and finish up Central Buttress."
Phototopo available.
Pete O'Sullivan, Roger Mear Apr/1980
Photo: 'Consecutive Sentence' and 'Legal Aid' montage. © andy_pemberton


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Menstrual cramps are no big deal for some girls, they can even go unnoticed. Unfortunately for other girls, this is not always the case and they must deal with them when they come most inconveniently. If your quinceañera happens to coincide with your menstrual period, then you must prepare yourself with remedies for menstrual cramps, especially if you usually experience changes in mood, fatigue, pain and other symptoms that may ruin your special day.
If you want to enjoy your quinceañera without having to worry about cramps, make sure to take note of the following fast and effective homemade remedies for menstrual cramps.
• Place a hot towel on your lower abdomen to ease the cramps. Besides the soothing feeling, this will block nerve signals of pain to your brain.
• Drink hot tea. Drinking something hot will raise your inner body temperature. For this, we recommend non-caffeinated drinks such as soup, broth, chamomile or cinnamon tea.
• Exercise. Stretching and exercise can help you release endorphins that function as natural antibiotics.
• Vitamins and minerals. Foods and supplements rich in Vitamin B, calcium, magnesium, and zinc can help reduce pain, swelling, and other symptoms of menstruation. We know that you want to avoid having cramps the day of your Quince at all costs, which is why if you suffer from them every month, make sure to prepare at least one week prior to your celebration.
To avoid future menstrual cramps we recommend:
• Eating foods rich in calcium such as fresh fruit and vegetables. Keep salty foods to a minimum, especially if you are experiencing swelling, since salt retains liquids.
• Drink plenty of water in order to release toxins.
• Avoid food that is high in saturated fat.
• Avoid drinking coffee, since it slows down calcium absorption.