text:
The MaterniT21 PLUS LDT is available solely through Sequenom CMM as a testing service to physicians. To learn more about the test, please visit Sequenomcmm.com.
About Sequenom
Sequenom, Inc. (NASDAQ: SQNM) is a life sciences company committed to improving healthcare through revolutionary genetic analysis solutions. Sequenom develops innovative technology, products and diagnostic tests that target and serve discovery and clinical research, and molecular diagnostics markets. The company was founded in 1994 and is headquartered in San Diego, California. Sequenom maintains a Web site at http://www.sequenom.com to which Sequenom regularly posts copies of its press releases as well as additional information about Sequenom. Interested persons can subscribe on the Sequenom Web site to email alerts or RSS feeds that are sent automatically when Sequenom issues press releases, files its reports with the Securities and Exchange Commission or posts certain other information to the Web site.
Sequenom CMM, LLC
Sequenom Center for Molecular Medicine® (Sequenom CMM), a CAP accredited and CLIA-certified molecular diagnostics laboratory, is developing a broad range of laboratory developed tests with a focus on prenatal and ophthalmic diseases and conditions. These laboratory-developed tests provide beneficial patient management options for obstetricians, geneticists and maternal fetal medicine specialists. Sequenom CMM is changing the landscape in genetic disorder diagnostics using proprietary cutting edge technologies.
Forward-Looking Statements
Except for the historical information contained herein, the matters set forth in this press release, including statements regarding the intended use for and capabilities of the MaterniT21 PLUS test, expe
|SOURCE Sequenom, Inc.
Copyright©2010 PR Newswire.
All rights reserved


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You may also like
Rate Dr. Diana Yun-Chi Wong
Dr. Diana Yun-Chi Wong's Ratings
This Dr. Is guilty of Wong doing. She is not professional, does not wear a Doctors robe and is not concerned with my problems. On top of that I was billed 195.99 for stopping by her office for her to only tell me to come back in a month.
Was this rating useful? 0 [[ userState['ratings'][2698638].votes_count ]]
I was looking for a new OB, so I went to meet with a few in person. Dr Diana Wong was one of them. I literally shook hands with this woman and had a 4-5 minute chat with her in her office. No exam, no vitals taken, nothing. Just a friendly introduction so I could meet the dr face to face. I have since been sent a bill for $205. I have absolutely no idea what this bill is for, and when I called her office all the receptionist said is that it was billed as an office visit. Is meeting a dr to see if you want to go to them now considered the same as a medical office visit? unbelievable.
Was this rating useful? 0 [[ userState['ratings'][2422266].votes_count ]]
Dr. Wong is very rushed and works as a part-time physician. Being a Dr. seems to her as just a "job" and she lacks passion for her profession. When she's not in the office, the answering service is extremely rude and unwilling to help. I'm having a problem and they do not refer you to another Dr. and they will not contact the Dr. for you. I will not return to Dr. Wong based on my most recent experience, when there are so many other physicians out there who give their patients the time and who genuinely care. What kind of a Dr. would not give a referral in an emergency????
Was this rating useful? 0 [[ userState['ratings'][766669].votes_count ]]
Dr. Wongs Sec. is so so rude. I am 13weeks Pregnant. I have been sick with a sinus infection for the past week. and everytime I call she does not want to schedule me a appointment to see Dr. Wong, or says i should go and see My family MD. She will also have Dr. Wong call you and just ask you thru the phone what is wrong, instead of coming in to the office and taking a look at you.
Was this rating useful? 0 [[ userState['ratings'][766668].votes_count ]]
Dr. Wong has been my OBGYN for a number of years and delivered both my kids and she will deliver any future children I have because she is wonderful. She is rarely late, provides excellent care and is always available. In all the years she has been my physician, she only cancelled one appointment and that was due to another patient's emergency c-section.
Was this rating useful? 0 [[ userState['ratings'][766667].votes_count ]]
She started off fine, but she tested me for something which she didn't bother to tell me I had until I had to ask her the following week. At which point she said, "Oh yeah, you do have that." It wasn't life threatening, but it wasn't great either! She spends about 5 minutes gossiping with her nurse and receptionist between patients whose office is right there so you can see and hear her. And which explains why she is always running behind. The receptionist is at best not friendly. The nurse is the only one I can say nice things about. I definitely would not recommend Dr. Wong or her office.
Was this rating useful? 0 [[ userState['ratings'][766666].votes_count ]]
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Why did you choose this product?
my fiance let me pick my own ring out since I'm the one who's going to be wearing it and he wasn't sure the exact type that I would like. when I showed him this ring he was shocked and said he never would have picked one like that for me. the rain came in the mail on December 11th and that's when my fiance proposed to me it's the most gorgeous thing I've ever seen in my life seriously. not only is the ring a great deal but you can find plenty of discounts for overstock.com anywhere just by becoming a member they give you discounts. so this ring was literally a steal for us. not only was my fiance thrilled that I got the ring of my dreams but the price was unbeatable. I highly recommend this room and we're in April now and the ring still looks as if it just came out of the box and I have not had it cleaned yet. this ring is worth well over the amount that you pay for it....
ITEM#: 13867493On the day you ask for her hand, wow her with this stunning diamond engagement ring. Fashioned in white gold, a double squared frame of smaller round accent diamonds forms the head of the ring, while the diamond-lined shank is a thoughtful touch.
- Center Stone:
- Diamonds: One
- Diamond cut: Round
- Diamond weight: 1/20 carat
- Color: H-I
- Clarity: I2
- Setting: Pave
- Diamonds: 42
- Diamond cut: Round
- Diamond weight: 3/8 carat
- Color: H-I
- Clarity: I2
- Setting: Pave
- Metal: 10k white gold
- Finish: High polish
- Ring style: Halo
- Ring setting dimensions: 20.69 mm wide x 25 mm long x 5.68 mm high
- Band: 2.5 mm wide
Diamond total weight: 1/2* carat TW
All weights and measurements are approximate and may vary slightly from the listed information. T.W. (total weight) is approximate. 1/2 carat T.W. may be 0.47 to 0.55 carat. Treatment code N (Diamond). See Treatment Guide for further information.
Click here for ring sizing guide
|Diamond Color
|Total Diamond Weight
|Up to .5 Carats
|Ring Style
|Composite Halo Side Stone
|Diamond Cut
|Gold Karat
|Gemstone Color
|Band Width
|2-3 mm
|Birthstone Month
|Cut Grade
|Very Good
|Jewelry Setting
|Metal Color
|See Description
|10kt Gold and Diamonds
|Model Number
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Customer Reviews
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love at first sight!
my fiance let me pick my own ring out since I'm the one who's going to be wearing it and he wasn't sure the exact type that I would like. when I showed him this ring he was shocked and said he never would have picked one like that for me. the rain came in the mail on December 11th and that's when my fiance proposed to me it's the most gorgeous thing I've ever seen in my life seriously. not only is the ring a great deal but you can find plenty of discounts for overstock.com anywhere just by becoming a member they give you discounts. so this ring was literally a steal for us. not only was my fiance thrilled that I got the ring of my dreams but the price was unbeatable. I highly recommend this room and we're in April now and the ring still looks as if it just came out of the box and I have not had it cleaned yet. this ring is worth well over the amount that you pay for it.Read More
Exceptionally Beautiful. Simple and elegant. Fits perfect on my hand. I am a 45 year old woman, 2nd marriage and desired simple. I love the vintage appearance. I receive compliments daily.... Wouldn't change a thing about this ring. LoveLoveLove!!!Read More
Was proposed to with this ring and I absolutely LOVED it. It's so breath-taking and indescribable. SO SPARKLY. Still in love with it 6 months later:)Read More
Wonderful product!
LOVE LOVE LOVE LOVE LOVE LOVE....A YEAR LATER, STILL IN LOVE!Read More
Returned it.
Based on the other review, I decided to give this ring a try. I did not like it and have returned it. The ring looks like it is made up of diamond shavings, not whole diamonds. Maybe that's how they got 1/2 ct to cover so much area? I bought a white gold, 1/2 ct wedding band from Overstock last year- that ring is absolutely perfect. Overstock has some nice rings, this is just not one of them.Read More
Engagement Ring
After purchasing this ring, my boyfriend decided to take it to a store in town and have it looked at to make sure because ordering off of a website can always be a little "scary." He took it to Kay's and the lady tested it and said it was real diamonds and real 10k white gold. He then asked her what she thought it was worth and she told him that in their store a ring like that would be sold for about $1,200-$1,500 easily. WOW. Not only did he get a GREAT deal, but the ring is gorgeous. I cannot stop staring at it!Read More
Love it.
I just recently got engaged to my boyfriend of over 4 years. When he asked, he presented me with this ring. This ring is ABSOLUTELY gorgeous! The picture does not do the actual ring justice. I love it! I get so many compliments everywhere I go. I am soooo impressed with it. :)Read More
Picture much better
I had to return the ring because the picture shows a much larger ring. I will try again with another ring.Read More
i just got this ring from my husband as an anniversary gift and i cannot say how much I love it enough. It is so perfect, and sparkly, these pictures just do not do it justice. Contrary to the other reviews, I feel as though the pictures are pretty accurate of what size to expect, it is definitely not small by any means. We brought it in to a jeweler today and the diamonds are all 100% real, and we told her what it was bought for, and she was very surprised that we got it for such a good price. My husband also bought a simple band with tiny diamonds to pair with this ring and it looks fantastic. I get compliments on it where ever I go. i LOVE IT!!Read More
This Ring didn't disappoint.... This coming from a big skeptic. It shines, sparkles and looks amazing. You will be elated at the number of people who think it is worth 5 times more than what you payed. Great ValueRead More
Questions & Answers
it was the ring my soon to be wife wanted
It's beautiful
My partners ring size is 11.5 and I am wondering if this ring comes in this size? thank you
or can be resized before purchasing?
Need to order this ring tomorrow, do you have plenty 1/2 karat in size9?
Hello dtcg797, This ring is so beautiful! I apologize for the delayed response. I see you were able to place your order, I hope you love this ring as much as we do. Thanks for shopping with us.
Since Overstock does not sale the wedding band separate is there a wedding band that you would recommend to go with the ring that you do sale?
Thank you for contacting us bdavis88. You will be contacted by Customer Care.
Are there any seperate wedding bands that match this exact band on this site? I'm wanting my wedding band to be this exact match to go right next to this one.
Hello erinpaige! This ring is gorgeous! Unfortunately, we don't offer the exact wedding band individually, but we do have this ring sold in a set with two wedding bands (item 14774254). I hope this helps. Thanks for shopping with us.
I noticed that item # 14774254 is the bridal set that consists of this same ring with 2 matching wedding bands. I have purchased this ring and I am interested purchasing the matching wedding bands, would you all sell the bands by themselves? If not, can I have a manufacture's website or some information of some sort to get the matching bands. Thank you!
Overstock.com has a wide range of diamond bands that would go perfectly with this ring. We are unable to disclose the manufacturer of some of our products; however, Overstock.com stands behind every product we sell. When necessary we can contact suppliers if a product issue arises.
Thank you for your help on my last question.I just have one more, how shiny are the diamonds? I've seen a few rings where the white gold overpowers the diamonds and after reading the negative review I was just wondering if this ring has that eye catching shine and pop that a lady would want and like? Thank you for your help.
This is of course an opinion, as was stated; the ring is small,dainty and beautiful.It does shine and looks very nice just look at the measurements so as not to be surprised at the size. The diamonds are the star of the ring.
Is the ring bulky in a finger? Such as would it get catch on fabric? Also, the clarity is I2, how noticeable are the inclusions? Is it possible to see a picture of this ring on a finger? Thanks!
The ring is in fact delicate and quite pretty.It may catch on fabric since it is raised. The picture makes it appear huge, but it is a very accurate. The inclusions are not noticeable.
Are the measurements for the height and width correct? The description says that it would be over an inch tall?
Yes, the measurements listed are accurate. The length is measured from the base of the band to the top of the setting, so in total it is slightly more than one inch or 26 mm tall.
Shopping Tips & Inspiration
How to Clean a Diamond Ring
How to Clean a Diamond Ring from Overstock.com. Clean your diamond ring at home each week with everyday household products.
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Diamond Cuts Fact Sheet
Diamond Cuts Fact Sheet from Overstock.com. A diamond's cut is crucial in displaying the stone's quality. Here's what you need to know when you're shopping for diamonds.
How to Buy Colored Diamonds
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Diamond Buying Guide
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How to Care for Clarity Enhanced Diamonds from Overstock.com. Clarity enhanced diamonds don't need a lot of extra care, just some routine maintenance.
Diamond Clarity Enhancement Quick Facts
Diamond Clarity Enhancement Quick Facts from Overstock.com. Clarity enhancement offers a major improvement on many stones, and enhanced diamonds may allow you to have a larger stone for your budget.
The Age of Agate
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text:
To link to this article, copy this persistent link:
(Feb 22, 2010) The Democratic Party of Japan (DPJ), the largest member of the country's ruling coalition since the fall of 2009, had submitted a bill to the Diet (parliament) in early 2009 that would have obligated the police and public prosecutors to videotape interviews with criminal suspects. (House of Councillors Bill No. 10, 171st Session.) The bill was not passed by both Houses of the Diet, however. The July 2009 DPJ election manifesto had included a plan to amend the Criminal Procedure Law as well, along the same lines as set forth in the bill.
After the unofficial leader of the DPJ, Secretary-General Ichiro Ozawa, his secretary, and a House member who is very close to him were interviewed by the Public Prosecutor's Office for violation of the Political Fund Regulation Law in January 2010, some DPJ members had called for swift enactment of legislation on the videotaping of such interviews. However, DPJ members who serve as the Minister of Justice and other Cabinet leaders publicly stated that submission of the bill must be examined carefully, in cooperation with the police and the Public Prosecutor's Office. (Kashi ka hōan kon kokkai de seiritsu o = minshu tirata shi [Enact Visually Reviewable Interviews Law in This Diet Session = DPJ Member Hirata Says], JIJI PRESS, Jan. 22, 2010, available at http://www.jiji.com/jc/zc?k=201001/2010012200614&rel=j&g=soc.)
On January 28, 2010, the Diet's Public Security Committee Chairman, Hiroshi Nakai, established a group to study the videotaping of interviews, as well as sting operations and plea bargains, for the next two years. The group held its first meeting on February 5, 2010. Nakai thinks it may be necessary to introduce new systems to make criminal investigations easier, such as the use of sting operations and plea bargaining, to balance any obligation to videotape entire interviews, since it is thought that would make investigation more difficult. (Seishi Chiyosaki, <Torishirabe kashi ka> Koan iincho no kenkyukai hatsu kaigo [<Visually Reviewable Interviews> First Study Group of Public Security Committee Chairman's Meeting Held], MAINICHI NEWSPAPER, Feb. 5, 2010, available at http://mainichi.jp/sel
Even under the former ruling coalition, the government had studied and planned the partial videotaping of interviews of criminal suspects. The Public Prosecutor's Office started a test program of videotaping such interviews in 2006. Since 2008, police and public prosecutors have been videotaping parts of interviews. (Japan Federation of Bar Associations, Torishirabe no kashi ka (torishirabe no zen katei no rokuga) jitsugen [Realization of Visually Reviewable Interviews (Videotaping Entire Process of Interviews)], http://www.nichibenren
.or.jp/ja/special_theme/investigation.html (last visited Feb. 5, 2010).)
|Sayuri Umeda More by this author
|Crime and law enforcement More on this topic
|Japan More about this jurisdiction
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Last updated: 02/22/2010


text:
Why Hire a Leadership Fellow?
You're looking for an accessible and effective way to get strategic insight into how your organization can fulfill its mission and have the greatest possible impact.
HBS MBAs are self-starters who are eager for the opportunity to experience leadership and management challenges in the nonprofit and public sectors early in their careers.
Emerging leaders need to develop an appreciation for and an understanding of the complexities of leading in the social sector.
Fellows bring a combination of on-the-ground experience and analytic rigor to the challenges facing any organization operating in a complex environment characterized by ever-increasing demands for services and recurring financial pressures.
Investing in the program is a one-year commitment with the potential to build long-term impact and skills into your organization and the sector at large. Some organizations hire Fellows to stay beyond the Fellowship year; others participate in the program over multiple years or pursue other channels of MBA recruiting to meet their ongoing talent needs.


text: [ Grocery Chain Owner Fatally Injured by Propeller By The Associated Press September 6, 2013 A Canadian police report says a Twin Cities grocery chain owner was fatally injured by the propeller of a float plane while on a fishing trip in Ontario. Read More|Comment Category: AP Stories, State/Regional News Tags: fatal accident, Kowalskis Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text:
Barbie, Barbie, Barbie.
I feel like Jan Brady complaining about Marcia Brady.; I know I shouldn't complain, but it's quite obvious that Barbie gets everything she ever wants. She always gets Ken--whether that's a good thing or not is debatable--she gets to keep her gorgeous figure without even working out, and she just got her Dream House remodeled and all paid for by her Pimp Daddy Mattel.
It must be nice to be Barbie.
Barbie's new Dream House isn't just any ordinary house; no, Barbie's new house has a chandelier made of hair. And not just anyone's hair, either. The hair on the chandelier is made of Barbie's own hair. There is also a mirror made from sixty-five different Barbies, which I think reflects the general public's desire to maim Barbie at some level. Mattel didn't just hire any ordinary interior designer either. The interior remodel on the expansive 3,500 square foot Malibu Barbie Dream House was done by interior designer Jonathon Atler. In typical Barbie fashion, every single thing in the house is pink, including the game room.
I hate it that I feel envious of Barbie's new remodel. It's not necessarily my style; it's just hard to accept the fact that whatever Barbie wants, Barbie gets without lifting a single finger. And, it's obvious from the photographs of the house that Jonathon Atler tailored the Malibu Barbie Dream home specifically to suit Barbie's needs. He is known for designs that are dedicated to bringing "style, craft, and joy, and general feeling of grooviness to your home." He definitely achieved this with Barbie's house, which he described as "happy chic."
While most of us could probably not afford to hire Jonathon Atler for any interior decorating, Jonathon Atler has a lot of items available for sale to the general public on his website. That said, don't expect to be able to purchase too many things from Barbie's house. If there are any chandeliers with Barbie-like hair on his website, I couldn't find them.
Many Barbie fans and craftspeople actually take the time to remodel the miniature Barbie dream houses for their children, nieces, and possibly pets. This post shows pictures from one woman's creative Barbie house remodel; note that this particular remodel is NOT in all pink.
How would you remodel a Malibu Barbie Dream Home?


text: COLUMBUS, GA - NOVEMBER 17: A Hardee's Monster Thickburger at a restaurant in Columbus, Georgia on November 17, 2004. The newly introduced hamburger is 2/3 of a pound of Angus beef and features four strips of crispy bacon, three slices of American cheese, and some mayonnaise on a buttered, toasted, sesame seed bun. The item reportedly tops out at 1,400 calories. (Photo by Erik S. Lesser/Getty Images) [ The Evolution of Pricing By Tom Egelhoff June 3, 2014 With all the conversation about the minimum wage, there needs to be another discussion about how that increase will affect the average consumer. Read More|Comment Category: AM 1450 Exclusive, Business, Commentary, Economy, Facebook, Internet, Lifestyle, Minimum Wage, Money, Opinion, Politics, Small Business Help, Technology, Tom's Opinion Tags: AM 1450 KMMS, automobile, bozeman, cable tv, california, carl's jr, cell phones, fast food, hardee's, Minimum Wage, montana, Obamacare, tom egelhoff Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text:
Backhouse Jones News.
Archive for November , 2011
Dancing the Night Away – Annual RHA Dinner a SuccessWednesday 30th November 2011
Backhouse Jones attended the RHA 60th Annual Banquet & Ball at The Old Swan, Harrogate on 19 November.
One Single "Tax Take" FigureThursday 17th November 2011
News Flash - One single "tax take" figure
"Where there's a will, there's a SAY" - Part 2Thursday 17th November 2011
Business is all about risk. The risk of losing, the risk of failing. The risk of letting clients and colleagues down. The risk of mentally falling to pieces and, if your job involves extensive driving, the risk of hurting yourself. The risk of dying.
"Where there's a will, there's a SAY" - Part 1Tuesday 15th November 2011
Make a will month
VOSA use new tactics to find rule breaking driversFriday 4th November 2011
The Vehicle and Operator Services Agency (VOSA) has been using social networking sites to find and catch out HGV drivers who are flouting the law by breaching drivers' hours regulations, Commercial Motor magazine reported.
HAIRY COMPETITION!Friday 4th November 2011
Face Grown & Hand Brushed MOVEMBER


text:
Saumi decides upon major reshuffle in quest to tame Falcons
Posted: November 29, 2012|
Plymouth Albion will make no fewer than seven changes to their team which lost at home to Bristol last weekend for tomorrow's trip to unbeaten Championship leaders Newcastle Falcons.
Head coach Nat Saumi has handed first Championship starts to young forwards Sam Matavesi and Tom Cowan-Dickie, while there are also returns for Rhodri McAtee, Lewis Warner, Luke Cowan-Dickie and Canada international pair Brett Beukeboom and Aaron Carpenter.
Making way through either injury, tiredness, loss of form or suspension are captain Sean-Michael Stephen, Paul Roberts, Bevon Armitage, Wayne Sprangle, Jon Vickers, Rupeni Nasiga, while Jack Andrew has been suspended by Albion for three weeks after picking up a red card for his part in a brawl against Bristol last week.
Stephen, Armitage, Vickers and Roberts have all started every league match for Albion this season. Stephen (neck) and Armitage (ankle) are struggling with injuries, while Vickers and Roberts take a rest on the bench.
It will be the first league game Armitage has missed since joining Albion in the summer of 2011. "Some players have not played well, some have played well but have played every game," Saumi explained. "I just think it is good for some new boys to come and stake a claim.
Saumi added: "We have not found any consistency and I think maybe a bit of complacency has been creeping in, But going into the next round [second half of the season] everything will be based on individual performances."
Henry Slade will start at fly-half at Kingston Park. It will be his first chance to wear Albion's number ten shirt for more than a year.
He started there twice early last season, but was then injured and missed the rest of the campaign, and this season he has been playing full-back.
However, the Plymouth-born dual registered back did impress at fly-half for Exeter Chiefs in their LV= Cup games against London Welsh and Ospreys and he gets his chance to try to repeat that form against the former Premiership club.
"Paul Roberts has been playing well, but this is a chance for Henry to have a go at ten," said Saumi. The Albion boss is also hoping hooker Tom Cowan-Dickie and Sam Matavesi will take their opportunities on their full league debuts.
Both players have made five replacement appearances for Albion in the Championship and have started cup matches, but they have never started a league game.
"These boys have been training very well," said Saumi. "It will be good to see them having a start in the league. Hopefully, they will take their opportunities."
Saumi is pleased to be able to welcome back Beukeboom and Carpenter following international duty for Canada.
The Albion boss hopes that Beukeboom's return will help with the line-out problems they had against Bristol. "We have spent a lot of time on the line-out in training," said Saumi. "Hopefully, Brett coming back should help as he is in charge of the line-out."
Despite the fact that Carpenter was named Albion's vice-captain at the start of the season, Sam Hocking will skipper the side in Stephen's absence tomorrow.
Saumi said: "Aaron is just coming back into the team, so we thought we would give it to Sam for the time being as he has been a very consistent performer for us."
Plymouth Albion: McAtee; Warner, Howley-Berridge, Fisilau, Bowen; Slade, Cushion; L Cowan-Dickie, T Cowan-Dickie, Fairbrother; Beukeboom, Tovey; Hocking (capt), Matavesi, Carpenter. Replacements: Roberts, Arnott, Morton, Rogers, Vickers, Ascroft-Leigh, Nasiga.


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Cigarette Production and CSR
For the capstone course we are supposed to do research which consists of research proposal, research diary and final report, which should include finally all the facts, knowledge of research question, final report is the result of the project. I was always interested in cigarette industry, I mean how do cigarette corporations like Philip Morris or British American Tobacco, for instance, promote and sell production even it is so harmful for our health. Therefore, my research question is the Cigarette industry and Corporate Social Responsibility. I have decided to base my research on Philip Morris International, because last term we were visiting its factory in Neuchatel and I had got a lot of knowledge about this multinational company.
First of all, I want to start with the definition of Corporate Social responsibility. According to EU definiton: CSR is a concept whereby companies integrate social and environmental concerns in their business operations and in their interaction with their stakeholders on a voluntary basis. Basically, the tobacco industry has used corporate social responsibility tactics to improve its corporate image with the public, press, and regulators who increasingly have grown to view it as a merchant of death. There is, however, an intractable problem that corporate social responsibility efforts can mask but not resolve: the tobacco industry's products are lethal when used as directed, and there is no amount of corporate social responsibility activity which can adjust that fundamental contradiction with ethical corporate citizenship. This study's focus is to better understand the tobacco industry's corporate social responsibility efforts and to assess whether there has been any substantive change in the way it does business with regard to the issue of exposure to secondhand smoke. The results show that the industry has made no...


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Welcome to the Legalesign API¶
Legalesign.com is an online eSignature service. This is the documentation for its REST-style API.
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Belton considers renovating second floor of its Town Hall
BELTON - The Belton Town Council will decide Dec. 2 how to proceed with use of $250,000 for renovation of its second floor at Town Hall.
The council on Monday heard a consultant discuss a variety of ways to use the property.
Bob Burriss took the council members on a tour of the upstairs rooms, which is now used for storage. Ideas for the seven rooms' use range from training facilities to Tri-County Technical College classrooms to Anderson County satellite offices.
The plans include using the original doors and molding still present from when the building was built in 1937 as an old school, having drop ceilings installed along with central heat and air and possibly adding an elevator so it would comply with the federal disability laws.
Burriss said about 60 contractors had been by to look at the project so that they could submit bids. The money is part of an Anderson County bond issue.
"It's nice to be receiving this money to be able to renovate the building," said Belton Mayor Rufus Callaham.
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text: Coming up to my second weigh in on Monday but I feel like im having a bad week. I feel more boated than I ever have is this normal for my sevond full week? Also I had a bad day yesterday, up umtil I fimished work I was having a great day, I hadnt used my syns at all. Then my boyfriend met me after work with a starbucks, we then went for a burrito, I tried my best to choose healthy but I'm terrified it will waste all my efforts this week. Any tips on how I can redeem m6self after a bad day?


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A new documentary about Princess Diana is stirring up controversy — and not just because it's being released right after the royal wedding. The film, called Unlawful Killing, is framed as an investigation of the 1997 Paris car crash that killed Diana and her boyfriend, Dodi Al Fayed. The documentary shows never-before-seen pictures of Diana at the crash site as she lay dying.
According to ABC News, British TV stations and movie theaters have refused to show the movie, but it will be screened this week at the Cannes Film Festival. The documentary is financed by Mohammaed Al Fayed, Dodi's father, who has suggested that Diana's death wasn't an accident at all, but instead planned by members of the royal family.
There has been no official comment about the film from any member of that family, and we don't expect there will be. But news of the movie and the drama it's creating will undoubtedly cast a shadow on all the celebration, pomp and circumstance the family has enjoyed over the last few weeks.
Take a look at a news report about the documentary, below.


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Killer Summer Conference: BlueGlass LA
Summertime, and the livin' is easy… and so is the learnin' if you're going to be in Los Angeles on July 19th. Read on for details and a 15% discount code.
BlueGlass LA is going to be an incredible conference, there is no doubt in my mind. The lineup of speakers is pretty ridiculous . I'm psyched to finally meet Dave McClure in person, who I've known since his PayPal days way back in the late '90s. Dave sponsored the LED Digest right during the dot-com crash of early 2000 and it really meant a lot to me at the time. Dave, you're good people, let me buy you a drink next week.
BlueGlass will take a bit of a different tack than most conferences do. There are search and social presentations to be sure, but also lots of content on getting startup funding and dealing with VCs. Check out the agenda for the full skinny.
It's going to be a pretty killer opportunity to learn about internet marketing and the VC game at one event. Not to mention killer networking.
Use this code to receive a 15% discount on your registration: audette15
I'm speaking on, "How not to FAIL at getting search traffic" with the hyper-awesome Vanessa Fox. Get her new book, if you haven't already.
Hope to see you there!
UPDATE – Here's my presentation on Slideshare, How to Not FAIL at SEO, by Adam Audette. The conference was a raging success. Incredible content and networking. I learned a ton.


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As of Wednesday, April 3, 2013
© Copyright 2015 Gwinnett Daily Post
LILBURN -- An Archer High School student who brought a gun to a track meet on Saturday said the weapon was his mother's for protection.
David Augustus Lee II, a sophomore at Archer, had the gun in a spare tire compartment of a 2005 GMC Envoy. When police contacted the student's parents, both claimed that the gun, a Bryco Arms Jennings 9mm semi-automatic pistol, was theirs, a Gwinnett County Police report said. Inside the magazine were 11 rounds of ammunition.
Lee was charged with possession of a weapon on school property and released from the Gwinnett jail on the same day.
The initial report, at about 9 a.m., came from a witness at Archer, who told police that Lee pulled into the parking lot in the Envoy as track coaches and athletes waited for a bus to arrive at about 8:10 a.m.
The witness said Lee and another man opened the vehicle's rear liftgate and removed the pistol.
"The suspect, while holding the gun in his left hand, used his right hand to pull the slide back, as if chambering a round," the report said as recalled by the witness.
After the other man looked at the pistol, Lee reholstered it and placed it back in the floorboard compartment, according to the witness.
Another officer arrived at Parkview at 10:25 a.m. Saturday, shortly after the fourth annual Big Orange Relays were scheduled to begin. An Archer track coach told police that Lee had driven his mother's car from Archer to Parkview.
After an administrator from Peachtree Ridge High School interviewed Lee, he and a Parkview administrator found the gun in the car.
More like this story
- Testimony: Oxycontin fueled burglary, killing ( October 21, 2011 )
- Top 10 most popular stories from April 1-7 ( April 7, 2013 )
- Archer High School students found with gun, knife ( September 18, 2015 )
- In brief ( October 7, 2006 )
- Police to guard Clayton Co. school buses after rifle threat ( May 16, 2012 )


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Public Garden Career Center - View Job
Regional Trees Initiative Coordinator
Category: Horticulture
The Morton Arboretum
Lisle, Illinois
Posted: Wednesday, December 18, 2013
Regional Trees Initiative Coordinator
The Morton Arboretum
Position Available: Regional Trees Initiative Coordinator Classification: Full-time, Non-exempt
Department: Community Trees
General Summary: Provide support for the development, coordination, communication, and administration of the Regional Trees Initiative and integration with the Community Trees Program. The Community Trees Program provides education and outreach to land managers and owners in order to improve management practices and the health of the urban forest. The Regional Trees Initiative is a collaborative effort, coordinated by The Morton Arboretum, to bring together leading organizations to work toward improving the urban forest throughout the Chicago Region.
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Previous Training and Experience
Experience in organizing meetings and presenting events or educational sessions. Experience with community and civic organizations and processes desirable. Familiarity with GIS mapping and analysis. Good communication skills, attention to detail, organizational skills, and customer service ethic required. Proficiency with Microsoft Office Suite essential. Experience with Constant Contact or other social media and web development is desired. Must possess a valid driver's license, which is subject to insurability and an annual Motor Vehicle Record (MVR) report.
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3. Travel to community events throughout the Chicago area; occasional distance travel via, auto, train, or airplane may be required.
If interested, please forward cover letter, salary requirements, and resume or application, to
The Morton Arboretum
Human Resources
4100 Illinois Route 53
Lisle, IL 60532-1293
or email to: firstname.lastname@example.com
The Morton Arboretum is an equal opportunity employer committed to achieving a diverse workforce.
Bachelor's degree required, Master's degree preferred, in the areas of forestry, horticulture, or
natural resource management. 2+ years experience in research or grant writing preferred.


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The second California-based installment of the Bravo franchise follows six Beverly Hills Housewives as they shop, schmooze, bicker, and live the lives of the rich and famous. Stars include former child actress Kim and Kyle Richards, and Camille Grammer, Kelsey Grammer's estranged wife.
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Bravo takes it to the Garden State for The Real Housewives of New Jersey. Deemed the most dramatic (so far) of the 'Housewives' franchise, the series follows five of the most affluent Jersey girls as they live lavish lifestyles and deal with all the drama that money can buy.
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Tag Archives: book review
Book Review: Pragmatic Version Control – Subversion 1.3
Once again the pragmatic book series has scored a home run. Pragmatic Version Control is part 1 in a 3 part starter kit on pragmatic programming. It is 11 chapters long and has several appendices that give more detailed information … Continue reading
Posted in Book Reviews Tagged book review, pragmatic programmers, subversion Leave a comment


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2011 Lauren's Run and CURE Childhood Cancer Annual Picnic
Thank you for visiting the Smiling Pirate's Gang fundraising page!
Since Joshua's diagnosis with an inoperable brain tumor in 08/03, CURE Childhood Cancer has been a very important organization to our family. Joshua endured two long chemotherapy protocols to battle against his tumor's progressions. CURE was always with us offering patient and family support, and hope for the future through the research they fund.
Please join us in our efforts to help CURE help our kids. Sponsoring us in any amount will be greatly appreciated!
Donating through this website is simple, fast and totally secure. It is also the most efficient way to support our fundraising efforts.
Many thanks for your support -- and don't forget to forward this to anyone who you think might want to donate too!


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Kenny Rogers
Listen to Kenny Rogers
and similar artists
Play Now
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Birth Name: Kenneth Ray Rogers
Born: 1938/08/21
Birth Place: Houston, Texas, United States
Years Active: 1958 - present
Genres: Country, Country Pop, Rock
Kenneth Donald "Kenny" Rogers (born August 21, 1938) is an American country music singer-songwriter, photographer, record producer, actor, and entrepreneur. He has charted more than 120 hit singles across various music genres and topping the country and pop album charts for more than 200 individual weeks in the United States alone. Rogers first outing was "Love Lifted Me." The album charted and two singles "Love Lifted Me" and "While The Feeling's Good" were minor hits. The song "Runaway Girl" was featured in the motion picture "Trackdown." Later in 1976, Rogers issued his second album, the self-titled "Kenny Rogers," whose first single "Laura (What's He Got That I Ain't Got)", ...
Kenny Rogers Makes A Big Announcement
These Stars Have Been Married HOW MANY TIMES?
Male Celebrities Who Have Had Plastic Surgery
Celebrity Plastic Surgery Gone Bad
These Stars Have Been Married HOW MANY TIMES?
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Kenny Rogers On Dolly Parton Affair Rumors: 'We Flirted For 30 Years'
Kenny Rogers: 'I've Been Married For 50 Years, Just Not To The Same Woman'
Kenny Rogers: Miley Cyrus Thinks Any Press Is Good Press
Kenny Rogers Dishes On His Friendships With Elvis, Michael Jackson
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September 6, 2012
File Photo
The 12th annual Atlanta British Car Fayre will be held on Saturday.
Stories this photo appears in:
British automobiles to invade Norcross
The 12th annual Atlanta British Car Fayre returns to Norcross with more than 150 automobiles on display.
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Melanie Thornton
May 13,1967---November 23,2001 Melanie Janene was born in Charleston, South Carolina and began studying voice from the age of six, as well as learning to play the piano and the clarinet. Growing up her mother would listen to Aretha Franklin, Roberta Flack. Melanie would mimic the female vocalists she saw on television or heard on radio. Later on she financed her college studies with appearances in talent shows and smaller band concerts. She frequented a club called The Peacock Lounge, getting up and doing jam sessions when the live band invited people up to sing.
No stations playing Melanie Thornton now
Wonderful Dream


text:
National Council on Teacher Quality - The National Council on Teacher Quality advocates for reforms in a broad range of teacher policies at the federal, state, and local levels in order to increase the number of effective teachers. In particular they recognize the absence of much of the evidence necessary to make a compelling case for change and seek to fill that void with a research agenda that has direct and practical implications for policy. They are committed to lending transparency and increasing public awareness about the four sets of institutions that have the greatest impact on teacher quality: states, teacher preparation programs, school districts and teachers' unions....The New Teacher Center - Housed at the University of California at Santa Cruz, this is the first center of its kind in the United States and is devoted exclusively to conducting research and providing technical assistance in issues of teacher mentoring and induction. Researchers are currently examining how teacher induction and mentorship programs affect teacher quality, retention and professional development, as well as student achievement....American Association of Colleges for Teacher Education (AACTE) - AACTE is a national, voluntary association of colleges and universities with undergraduate or graduate programs that prepare professional educators. This Web site provides information on accreditation and governmental issues pertaining to teacher preparation issues....National Center for Education Information (NCEI) - NCEI is a private, nonpartisan research organization specializing in survey research and data analysis. It offers many sources of information about alternative teacher preparation and certification, has conducted several national and state studies of teachers, school administrators, school board presidents, state departments of education, local school districts and individuals interested in becoming teachers. In addition, NCEI has produced numerous data-based reports in the last decade that can be downloaded or ordered from this Web site....Teacher Education Accreditation Council (TEAC) - TEAC is a nonprofit organization of institutions of higher education and other groups and individuals devoted to improving academic degree programs for professional educators. The council's primary work is assuring program quality by verifying evidence that institutions of higher education prepare competent, caring and qualified professional educators. The accreditation process, publications and other related information can be found here....State Higher Education Executive Officers (SHEEO) - SHEEO is a nonprofit, nationwide association of the chief executive officers serving statewide coordinating and governing boards of postsecondary education. This site offers multiple publications and Web links on key issue areas of P-16 reform, including: K-16 initiatives, teacher education, remediation, admissions, early outreach, curricular reform, access and diversity, and workforce development. SHEEO's recent project, Enhancing the Teaching Profession: The Importance of Mobility to Recruitment and Retention, has produced several new publications....
Information provided by ECS combines the best of the most recent and useful
research available. Should you have questions, please contact our Information
Clearinghouse at 303.299.3675.


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Three women in list of 20 appointed silk in Victoria
/ Nov 27, 2012 9:36AM / / ()
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Victorian Chief Justice Marilyn Warren has appointed 20 new Senior Counsel today, three of whom are women.
The women appointed include Suzanne McNicol, Aileen Ryan and Carolyn Sparke. There were 71 silk applications all up, 66 from men and five from women.
In Victoria, the gap between male and female barrister is wide with 1,411 male barristers compared to just 471 female barristers according to the Victoria Bar.
NSW recently appointed a record number of female silks, with 12 of the 26 barrister appointed female. Women account for less than 20% of female barrister in the state, according to Lawyers Weekly.
Justice Warren said in a statement that the group represented a wide-cross-section of advocates. "The appointees were selected after a wide and demanding consultative process involving the higher courts and tribunals, the Victorian Bar and the Law Institute and other senior members of the legal profession", she said.
The silks will be welcomed during a ceremonial sitting of the Supreme Court on 7 December. See the full list.
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Murchie's Tribute Puerh - This modern Puerh is soft and easy to drink. Not at all astringent, it has the expected earthiness of a Puerh, but with a ripe melon overtone and hints of berries and florals.Learn More


text: [ Two Utica Residents Facing Animal Cruelty Charges By Jim Rondenelli April 11, 2012 Utica, NY (WIBX) - Two people are facing animal cruelty charges after Utica Police were called to a home on Flagg Avenue. Read More|Comment Category: Utica-Rome News Tags: animal cruelty, cral seldin, suzanne evans, utica police department Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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Posted by Derek
Christoph Westphal gave what by all accounts was a very interesting talk at the recent Bio-IT conference. And considering his track record in company formation, he's well worth listening to. But concerning the recent controversy over the compounds and results from his most recent success (Sirtris), I found this part of his speech. . .well, interesting:
"There's a debate in the academic world," Westphal acknowledged. "We don't know the specific molecular mechanism of why you need a specific substrate on the in vitro screen to find Sirt1 activators. Pfizer, Amgen, GSK, Sirtris, everyone in academia agrees on that. Then the question is: Is the mechanism direct on SIRT1 or indirect on SIRT1? Everyone in the field agrees our molecules have beneficial effects in animals, and I hope they will in man soon. The specifics of the mechanism are under debate. This kind of thing will be debated for ten years."
Emphasis mine. And I emphasize that part because Pfizer specifically tested one of the highlighted Sirtris compounds, SRT1720, and was unable to reproduce the in vivo effects. So no, I wouldn't say that "everyone agrees" on this point. Not quite.
Westphal says that there's another paper in press that might be able to clear things up a bit, so we'll see what that one has to say. And he's right that the clinical results are what will really settle these questions - but we're going to have to wait a while for those. For now, agreement on a lot of key points remains hard to come by. . .
Comments (36)
+ TrackBacks (0) | Category: Aging and Lifespan | Business and Markets
1. lewis robinson on April 28, 2010 8:57 AM writes...
People have been proposing this sort of the for 20+ years. Here's one from the recent past.
[ Proc. Natl. Acad. Sci. vol. 101 pp. 14091 - 14096 '04 ] Human cells can make morphine and other opiate alkaloids. They were identified by gas chromatography/tandem mass sepctroscopy. It has been thought that although opiates can be found in the body (at nanoMolar concentrations) they were of dietary origin. Not so, a neuroblastoma cell line grown in an18-Oxygen isotope atmosphere had morphine found by the same technique with 4 more mass units (there are 3 oxygens in morphine so it should have been 6 units higher). Nonetheless, a fairly convincing demonstration of biosynthetic capacity.
2. sgcox on April 28, 2010 9:25 AM writes...
"...He announced his resignation as Sirtris CEO the very next day..."
Don't think he actually has much trust in it.
3. Hap on April 28, 2010 9:32 AM writes...
It's not all that encouraging to see that they either don't care what other people's responses are (they can't be right) or are being dishonest (since it's plainly false).
I also don't really understand what the point of the money spent on Sirtris is if you have no idea whether the compounds act by sirtuin-mediated pathways - if that's the case, Sirtris's IP didn't get GSK much that they couldn't have gotten without them and with the $720M that they spent buying Sirtris (though I'd guess the latter explains the former - that would be a conclusion the Sirtris people would prefer GSK not make).
4. Will on April 28, 2010 9:54 AM writes...
I saw the new CEO of Sirtus George Vlasuk present at the Arizona SBS conference about two weeks ago.
His talk was basically a point by point rebuttal to the Pfizer JBC paper.
By the look of it- the Sirtus group retrospectively went back and found a peptide substrate that worked with the Sirtus molecules (albeit very weakly).
This was obviously a non-physiological substrate (6 or 7 mer).
Therefore they claim that their molecules are Sirt activators- and Pfizer, Amgen, etc.. don't understand Sirt biology the way that Sirtus does.
5. anon the II on April 28, 2010 10:04 AM writes...
This is so damned depressing. The unfortunate truth is that the "Westphal"'s are the successful people in this industry. And the money that these guys are sucking out of the industry could employ a whole bunch of talented, hard-working and honest scientists for a long time. I think I've said it here before that once DTC moved the industry from being science-dominated to marketing-dominated, our fate was sealed. The successful people are the ones who can spin and spin and spin. It's just a game to them.
6. MTK on April 29, 2010 1:33 PM writes...
Anon the II,
Let me play the contrarian here. Westphal is a success story with no sarcasm. And the capital generated was being used to employ people.
Sirtris stockholders just didn't take the money, close up shop, and run to the islands. It was used to employ people and conduct research. The money that the VC's and initial investors make will be put into new ventures and companies that will also employ people. Sure some of it will go to vacation homes in Hamptons, but the majority of it will go back into the system in some form.
I wouldn't be so quick to dismiss the Westphals of the world.
7. Hap on April 29, 2010 1:55 PM writes...
But it could have been used for better research too, both from GSK and from the companies that would have been funded instead.
If you can't trust their research, why can you trust their investments?
8. MTK on April 29, 2010 5:26 PM writes...
Perhaps, Hap, perhaps.
Westphal's words and the title of the post remind me of a song
"Cause everybody knows, that nobody really knows,
just how to make it work or how to ease the hurt.
We've heard it all before, that everybody knows
how to make it right, I wish we gave it one more try
One more try
Cause everybody knows, but nobody really knows."
9. Hap on April 29, 2010 6:03 PM writes...
Yeah, that's about right. Alternatively,
"When a distinguished but elderly scientist states that something is possible, he is almost certainly right. When he states that something is impossible, he is probably wrong."
The less-than-refeshing honesty isn't encouraging though.
10. Ray on April 29, 2010 6:41 PM writes...
Anybody on this board have a view on taking resveratrol as a supplement? If so please share. I've been taking 350mg since I read about Sirtris. Its since become a craze and my doubts are increasing. This story doesn't help.
11. Open Eyes on April 29, 2010 7:38 PM writes...
To #6 MTK:
You need to get the picture right and your total facts straight. It was acknowledged internally that part of GSK's restructuring in 2008 / 2009 involved fired dozens of staff in R&D to create funds to help pay for the Sirtris deal. Almost certainly, more positions were let go by GSK to fund the deal than are being employed in Cambridge.
For many inside GSK seeing this very sad drama play out in slow motion has been demoralizing. Interactions with staff from other sites with those in Cambridge remain difficult, data that has been stated as available by Sirtris has turned out to be non-existent, attitudes in Cambridge remain defensive. Many staff at the core GSK R&D sites want to have nothing to do with the Sirtis staff, their compounds, or their activities, seeing the entire scheme as professionally, scientifically, & ethically reprehensible.
What is most unfortunate is that many inside R&D in GSK who remain interested in trying to make new drugs, who cooperate and work toward group goals & objectives, have been treated as pariahs in favor of those who talk the talk, but don't know what is involved to walk the walk. Sirtris is held by management all the way to Witty as the prototype of the future of drug discovery. In cases where well respected staff have spoken with balanced perspective that may have not completely absorbed the Sirtis centric view, staff positions have been rapidly replaced by Westphal supporters or eliminated.
Adding insult to injury, Westphal was recently appointed to head SR-One, the company's long running venture group, while at the same time continuing as a partner of Longwood Founders Fund, a privately held venture capital group. The two hats clearly are a confict of interest in being able to have impartial evaluations of funding opportunities for the best interest of GSK vs. further padding the pockets of C. Westphal and his other VC partners.
Those like Westphal are no different from the greedy, arrogant, self-abosrbed, unreflective members of investment firms such as Goldman. Their ultimate goal is simply to re-arrange paper in moving money from wherever they can get it into their pockets.
12. MTK on April 30, 2010 7:07 AM writes...
Did Sirtris have scientists employed? Did they not raise money from investors and VC's to pay those scientists? Now that the investors and VC's have gotten a return on their investment will that money not be reinvested in new ventures employing new scientists? Did not GSK cut the jobs within GSK, because it certainly wasn't Sirtris.
I have no idea if the net outcome in jobs is negative or positive and neither do you, because that money will go into other future ventures that will hire people.
You know what gets me. People who blame the Westphal's of the world for their woes. People who characterize a man they probably have never met and don't know in the least as arrogant, greedy, self-absorbed, and unreflective. They have no idea about the character of the human being. They blame him for job losses, when the reality is he's created jobs. GSK is the one that cut the jobs, not Sirtris.
Don't like his ilk? Fine. Since you are clearly a better human being than westphal, then live up to your own higher principles and not work for any company that has been funded by VC's or started by such greedy, arrogant, self-absorbed people who would (gasp!) look to get a return on their investment. Good luck in your consulting career where you'll add so much more value.
13. MTK on April 30, 2010 7:40 AM writes...
And another thing #11...
All your complaints are essentially with GSK management as far as I can tell. So who do you take out on? The Sirtris folks, of course. You refuse to cooperate with them. You stamp your feet, hold your breath, and don't want to have anything to do "with the Sirtis staff, their compounds, or their activities".
Bravo, sir. That'll show 'em.
14. Anonymous on April 30, 2010 7:59 AM writes...
MTK, do you approve of boiler stock rooms or Ponzi schemes ?
Sirtris folk are not that different. Selling assay artifacts (knownly) is a fraud IMHO
15. Anonymous on April 30, 2010 8:18 AM writes...
You've missed the whole point. The criticism of Sirtris is based on the fact that their drugs in development are pure snake-oil. The science supporting their candidates is so sloppy and has been so thoroughly refuted in the published literature, it is impossible to continue to promote this stuff without willfully rejecting reality.
It doesn't matter how many people Sirtris employs or how the VC's invest their profits. If research money spent at Sirtris is going toward supporting something that is a total scientific fraud, then this is a deadweight loss for society. If productive resources at GSK were redirected to Sirtris to further advance this fraud, then that is a further loss to society.
16. noname on April 30, 2010 8:43 AM writes...
The Sirtris scientists are just like the rest of us. They worked hard, they used their brains, they acted as a team, and they solved the scientific questions they were asked to solve. In fact, they probably did so more efficiently than GSK scientists could have, because of the intrinsic efficiencies of small organizations. That efficiency is what Witty et al are touting, "doing more with less."
Unfortunately, while the R&D model was right, the science was wrong. I don't know exactly what was said in the diligence meetings but people on both sides of the deal seemed to have dropped the ball. Someone at the upper levels of Sirtris should have constantly been playing the contrarian, questioning everything. Likewise at GSK. As far as Westphal, I'm guessing he formed a narrative of success and excitement that noone wanted to puncture with data. On the one hand it is the role of the CEO to cheerlead the troops, keep them positive, and drive them towards the value point. On the other hand, they do a disservice if the vision is simply profit based on sloppy science.
In the end, Westphal is wounded. Particularly if the SRT compounds crash and burnm I predict he is out of GSK before Moncef. He will certainly not survive a change in R&D head unless something big happens with the compounds. Then you have to wonder, will the next start-up want him as CEO, despite the track record, with a sullied reputation in the eyes of the customer big pharma? Likewise will VCs want him as their gold sniffer, given that big pharma will view his discoveries with suspicion.
He probably will just end up on the beach. A bad ending to this story leaves him nowhere else to go.
17. Anonymous on April 30, 2010 9:02 AM writes...
"He probably will just end up on the beach. A bad ending to this story leaves him nowhere else to go."
Not at all... Sirtris people are climbing the GSK hierarchy, and this AFTER the papers exposing the sloppiness of Sirtris biology and chemistry.
all criticism here is about great success based on dubious science (while the GSK guys that developed Tykerb are out of the game).
18. Hap on April 30, 2010 9:26 AM writes...
Perhaps this is another example of "Bad money chases out good."
19. Anon on April 30, 2010 10:03 AM writes...
It would be one thing if Sirtis would still be standing alone to prove hypotheses and claims. But when others were told they had to leave jobs at GSK to pay for the deal, when the big bucks needed to conduct clinical trials as the ultimate determiner to resolve the debate now comes from GSK, the two are no longer independent.
With multiple examples where those doing experiments at Sirtris repeatedly having refused to show GSKers results from experiments, when data that was claimed to exist later turned out not to have been determined and only to be divulged after much harranging, the scientists have proven themselves to be equally culpable, sad as that is to say. Fair or not, from the outside looking in, everyone becomes tainted since it is impossible to know who is ever telling the truth. By the way, it seems that more recent disclosures seem coincident upon departure of original Sirtris scientists and those assuming responsibilities being more forthcoming.
Don't get this wrong. I am a big supporter of biotechs, startups, VC funding and understand concepts of "exit strategies" to get return of investment. But, not to the extent of endlessly promoting & defending poor science for the purpose of ego & personal image.
#16: Only if it were so easy to isolate the Westphal's of the world. Take a look at the members of the board along with the VCs providing financial backing to Concert Pharmaceuticals.
20. Petros on April 30, 2010 11:14 AM writes...
Looking at some of the stories on sirtris I googled MIchelle Dipp, founder and now VP for GSK's CEDD for external discovery.
She is 33 and her only experience of industry has been at Sirtris!
21. MTK on April 30, 2010 11:54 AM writes...
I'm not missing the whole point at all. Here's the story as put out by #11. a) GSK buys Sirtris for $720M. b) GSK lays off people to afford Sirtris. c)Sirtris' science stinks, d) Sirtris CEO is an arrogant, greedy, self-absorbed and unreflective, e)#11 refuses to play ball with new colleagues who came from Sirtris because they're to blame for layoffs.
This, of course, completely fails to acknowledge that GSK signed an industry leading 67 deals in 08-09 alone. I don't know the cost of all these deals, along with more recent ones, but Synta, Concert, NanoBio, Targacept, Anacora, and Isis alone cost $220M in upfront payments. that doesn't include future milestone payments which could be in the billions. (And no those milestones don't start at FDA approval.) That's just for 10% of the deals they have made. The tip of the iceberg.
Sirtris, regardless of whether they sold snake oil or not, is not the reason for the layoffs at GSK, merely symptomatic. They are one, maybe the single priciest one to date, but still just one of dozens of deals made by GSK management, all of which have to be paid for. Sirtris in itself did not lead to the layoffs and reorganization despite characterizations to the contrary.
So why did GSK management feel the need to turn so decidedly to the outside in general, not just to Sirtris?
I'm sure y'all have your opinions, but let me give you one incorrect answer. Because some arrogant, greedy, self-absorbed, unreflective SOB named Westphal hoodwinked GSK costing me my job.
Like it or not, the Westphals of the world are right now the primary hirers of scientists. I would not be so rash as to demonize them nor shun earnest and sincere people working for them simply due to association. You may soon be one of them.
22. Hap on April 30, 2010 1:18 PM writes...
To buy snake oil, doesn't someone have to sell it? The fact that people at GSK were not diligent enough (or had other incentives) to fully vet the deal doesn't excuse selling something you either don't have sufficient evidence to claim works or know isn't what you claim. And none of this excuses either Sirtris's or GSK's management not being able to tell the truth after the fact, and hosing the investors and others in GSK.
People who drive the formation of companies aren't bad in themselves - they're driven by the same things other people are, and help to create the value everyone wants. Being dishonest in the service of your ends, though, is supposed to be frowned upon, whether individual, small company, or big company. The fact that lots of money is generated by the dishonesty doesn't make it any less wrong, or any less destructive.
There might be something in the sirtuin pathway of use, and hence a reason for the company and employees to still believe in their goals. It's never right to be dishonest to serve that end. When people do so, it makes it appear less likely that the people leading the company actually believe those goals (and thus that the company can actually do something useful towards that end). It is counterproductive on lots of levels - it tells your employees that they should wonder whether management has any faith in them or their mission, makes their new employers look bad, and angers their investors. A fine bit of work.
23. MTK on April 30, 2010 2:26 PM writes...
I agree wholeheartedly.
Do we know that they are being intentionally dishonest? Being shoddy and being fraudalent are completely different things. One can have honest differences in opinion and also honestly come to different conclusions based on factual data. Or one can have misguided faith, but sincerely believe in it. All of these are mistakes. We all make them. That doesn't make one a bad person, that makes one human.
I could be wrong, but I don't see the whole sirtuin story as out and out dishonesty. I view it, so far, as faulty conclusions based on sketchy experimentation.
My beef here is with wholesale condemnation of a person's character, because folks are blaming the Sirtris deal for GSK layoffs, which let's be honest, is exactly what is happening. Of course, this ignores all the other deals including one for Reliant which GSK paid $1.65B.
For all I know, Christoph Westphal may be a bad person. Or he might be the greatest guy around. I have no idea. I've never met the man.
Here's what I do know. He has co-founded four companies which currently employ about 500 people directly. He's provided a healthy return to investors who have undoubtedly used the funds in other companies employing other people. He's still working in a VC capacity providing others with the necessary capital to get their companies going and employing people. He could easily just be sitting back and doing nothing.
Does this make him a great guy? No. But it does make him and people like him important to the future of our industry.
24. Anon on April 30, 2010 3:15 PM writes...
Ahhhh ....
it is all now so clear, so very simple .....
people who deliberately defend poor science but make a bundle at the expense of many innocent others should be honored and respected .....
yes, so very very clear .....
25. Hap on April 30, 2010 3:37 PM writes...
I don't know how honest Westphal has been, or rather how honest Sirtris has been (and how much that can be mapped onto any one person in particular). Saying that "Everyone in the field agrees that our compounds have beneficial effects in animals" is clearly wrong - Pfizer and Amgen have said so in print. P and A could be wrong, but it's obvious they don't agree. He could have said something else - "Our data shows that these compunds work in animals, and we believe that further research and clinical data will bear that out", for example. There is a utility to supposing unanimity, but if isn't true, well, then you do the best you can with what you have.
A lot of the complaints, though, probably don't come on to Westphal so much as Sirtris in general - the problems with the assays seem unresolved and highly problematic (if you have to use a fluorescent marker in NMR assays, as someone noted in one of the previous posts, something's probably wrong, or there needs to be a good explanation). That could be sloppiness for Sirtris or it could be wrong (there might be something in P or A's work that is incorrect). The problem, and what makes Sirtris look dishonest, is that the statements of people responding to those issues rely on either insult (you don't know what you have - well, if you published better procedures, so that we could, that might be a defensible counterargument, but...) or wish fulfillment (no, the contrary data is wrong, or isn't what it says). Mistakes people can understand, but spin, not as much. Spin makes people think that what you've got is less than you're saying (which is its intent), and is not as forgivable. That may be necessary for investors, but in itself, that's a problem.
If investing in biotech/small companies becomes a con game, dependent on how well companies can fool people or keep them in the dark, who does that benefit? It doesn't benefit small companies unless they're willing to be dishonest (the supplement game). It doesn't benefit the big companies that might want to purchase them, because it may cost them significant money to get to the point where they can even look at real data to see what's real and what's spin. It doesn't benefit investors, because most of them will get taken. It doesn't benefit employees, because if spin, and not substance, is what matters, then their fates have nothing to do with what they can actually do for their employer, since it may not care. It doesn't likely benefit people in general, because there's little reason for companies to produce actual products, or at least less of one than under a more honest system. Overall, the likely outcomes seem bad for almost everyone except the dishonest.
26. MTK on April 30, 2010 3:53 PM writes...
where did I say he should be honored and respected? I said he was important to the industry. I made it quite clear that I make no judgments about him as a person.
As for making a bundle at the expense of the innocent...who exactly are these innocents that would have retained their jobs if not for Sirtris?
As I pointed out earlier, GSK made 67 deals in two years. Sirtris was one. It even wasn't the biggest one, that would be Reliant at $1.65B. Six other deals in my simple search revealed $220M more in upfront payments. That's a $36mil/deal average. That leaves 60 or so unaccounted. Let's say those averaged a paltry $10mil in upfront payments, that means a conservative estimate of $2.4B in deals outside of Sirtris. Now let's throw in the revenue lost from Avandia sales. In 2006 Avandia sold $2.5B, in 2009 $1.2B. Over the last three years it's about $2.5B in revenue losses even if sales had stayed static vs. 2006.
And did you not happen to see that the every other Big Pharma company has had massive layoffs also?
Oh, I see. Despite losing billions in Avandia revenue, spending at least another $2.4B on dozens of other deals, and the fact that every other Big Pharma was laying off people, somehow GSK was going to buck the industry trend on layoffs if it wasn't for that darn Sirtris deal and the music man, Christoph Westphal. C'mon. Let's be reasonable here. The villification of Westphal is nothing more than scapegoating.
27. Anon on April 30, 2010 4:40 PM writes...
so very clear, so very simple....
all problems with Pharma justify the means to anyone's ends....
so very clear, so very simple....
push button 1, response 1.....
push button 2, response 2.....
so very clear, so very simple......
28. MTK on April 30, 2010 7:19 PM writes...
Anon 24 and 26 (the same person I assume given the language),
Thanks for bringing nothing to the table beyond "so clear, so very simple."
29. sgcox on May 1, 2010 2:06 AM writes...
just small clarification, I made error in my old post. According to Sirtris patents, assay uses masss spec of labeled peptide, not NMR. Sorry.
Don't have Pfizer paper at home but I believe they used the same method and showed the compounds inactive when used non-labeled peptides
30. Anon on May 1, 2010 8:48 AM writes...
It's been a blast pushing your buttons.
Time to enjoy the weekend.
Ta Ta for now.
31. Tom Daschle on May 1, 2010 10:48 PM writes...
Sirtris keeps saying its compounds are 1000 times more powerful than resveratrol...solution in search of a problem?
Do you think David Sinclair is glad he met Westphal?
Why is Westphal leaving Sirtris? Are they on auto pilot? Or, is there nothing there?
What happened to Sirtris's huge PR campaign?...it has all but vanished....astonishingly so.
32. Anon on May 2, 2010 5:58 AM writes...
What about the other two co-chairs of the Sirtrus scientific advisory board? What enormous cut of the action did they get in exchange for lending for their presitigious scientific creditionals? Weren't they the ones paid to assure that the science was high quality?
33. cancer_man on May 3, 2010 8:56 AM writes...
The SRT 501 study of meyeloma was suspended a couple of weeks ago for safety concerns.
34. Bill Sardi on May 3, 2010 3:46 PM writes...
Me no comprende the online comments. Resveratrol as Sirtris' SRT501 is something very similar to what is currently being sold in health food stores today as a dietary supplement. This is conceded in prior SEC 10k filing by Sirtris.
One brand of resveratrol-based pill, Longevinex, stabilized via microencapsulation and micronized to enhance absorption, presented in a matrix of other small molecules, has been shown to differentiate 9-fold more genes than plain resveratrol and to reduce blood sugar better than plain resveratrol or even a limited-calorie diet, something never demonstrated before!
Life-long calorie restriction (CR)differentiates about 900-1000 genes in rodent heart tissue. Short-term CR differentiates ~198 genes, short-term resveratrol ~225 genes, short-term Longevinex ~1711 genes in rodent heart tissue, meaning Longevinex works to immediately produce genomic effects similar to those produced by life-long adherence to a limited calorie diet. [Experimental Gerontology 2008]
However, genes do not express proteins on their own. The proposed mechanism that underlies the genomic effect is mineral chelation. The progressive accumulation of minerals, particularly iron, copper and calcium, which begins after full-growth is achieved in males and the onset of menopause in females, explains why males have shorter life spans than females.
Small-molecule chelators, such as those found in red wine, work at a modest dose, in a superior manner to mega-doses, to produce unusual health benefits and longevity.
Longevinex has even been shown to exert a "pre-conditioning" effect at a relatively low dose, avoiding mortality among rodents subjected to a chemically-induced heart attack. (Study in press) This is significant since 50% of those adults who succumb to a sudden-mortal heart attack were taking a baby aspirin on the day of their demise. Low-dose aspirin isn't working.
These beneficial effects have been documented at equivalent lower human doses than the often quoted "1000 bottles of wine" that is mistakenly said to be required to mimic calorie restriction.
Since the FDA will never approve a pill for longevity because conclusive evidence would require a 99-year human study, it appears that markers of aging or longevity (gene expression, red cell width, labile iron, lipofuscin accumulation) may need to be evaluated.
In this regard, Longevinex was shown in a proof-of-principle study to reduce lipofuscin accumulation in the human retina which correlated with improvement in 5 measurable parameters of vision in an 80+-year old male. This was another biological first. Reversal of biological aging may be at hand.
The day approaches when biological age could be non-invasively determined via retinal photography and a mineral-chelating pill be used to remove cellular debris (lipofuscin), a known marker of aging.
A nutriceutical may be more amenable to promotion of health and longevity than an FDA-approved drug, an agency which uses a drug/disease model for approval.
In this regard, red wine in moderation is already shown to produce greater longevity compared to tea-totalers. Dark, aged red wine, or a pill which is demonstrated to provide similar effects without the alcohol, sugars and sulfites, would be an affordable way to promote longevity without drugs.
The amount of red wine to produce optimal effect is 3-5 glasses per day, or $7 or more per day, versus a nutriceutical at less than $1 per day. Any pharmaceutical resveratrol pill would probably be as costly as 3-5 glasses of wine and beyond the affordability of most consumers.
Bill Sardi, managing partner
Resveratrol Partners LLC, dba LONGEVINEX
35. Spiny Norman on May 8, 2010 9:43 PM writes...
"One brand of resveratrol-based pill, Longevinex, stabilized via microencapsulation and micronized to enhance absorption, presented in a matrix of other small molecules, has been shown to differentiate 9-fold more genes than plain resveratrol..."
Gotta love it when idiot salesmen don't even realize that they are spewing gibberish.
36. Scientist on June 1, 2010 5:04 PM writes...
Billy, you should let the big kids play in this playground since we'll call you out on your nonsense. Someone should sue you for the false claims made on your website, but you can claim ignorance.
What do you think of "mineral-chelating pill be used to remove cellular debris?" Does he think a cell is a garage?
What is cellular debris? DNA damage? Oxidation of Glucose? Ribose going from a pentose to a furanose? Downregulation of HSP90? Crossing over events or basal bodies? The formation of inclusion bodies? Or is it the removal of the telomeres?
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