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Chris Boardman video asks, Who Are Cycle Lanes For? ahead of Parliamentary Inquiry appearance (+ video)
Former world and Olympuc champ to give evidence to Get Britain Cycling inquiry
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Former world and Olympic champion and Tour de France maillot jaune Chris Boardman has produced a short film for British Cycling that poses the question, Who Are Cycle Lanes For? The film has been released ahead of his appearance on Wednesday before the 'Get Britain Cycling' Parliamentary Inquiry, the fourth of six sessions and focusing in part on how to turn Britain's sporting success into getting more people riding bikes.
That's part of a wider look at the health aspects of cycling, including promoting it in schools and the workplace and access to facilities, with other witnesses including Phil Insall of Sustrans and public health and transport consultant Dr Adrian Davies.
They will be joined by representatives of the Department of Health, the Cycle to Work Alliance, NICE, the Forestry Commission, the Department for Culture, Media and Sport, Natural England and Mountbatten School, Hampshire.
The session, held in Committee Room 8 of the House of Commons, lasts from 9.30am to 11.30am and can be followed on Twitter via the hashtag #GetBritainCycling. The final two sessions will look at 'The Local Perspective' on 27 February, and 'Government' on 4 March, ahead of a report being published in April.
Boardman's short, near silent film – no voiceover, just the rumble of wheels, the odd click of gears, and the noise of passing traffic – highlights just some of the obstacles that stop discourage people from taking to two wheels, in the physical sense at least.
Those include cycle lanes that end abruptly, then reappear to direct riders onto poorly maintained shared footways where they must dodge road signs, and give way to motorised traffic before rejoining the road.
A short journey from British Cycling on Vimeo.
"We need to start asking ourselves questions – big ones like 'what do we want the places in which we live to look like?' and smaller ones like: 'who are cycle lanes for?'," explained Boardman.
"When we consider questions like these, I think the answers will lead us in one direction: we need more and better provision for people who want to travel by bike.
"When we have that, our towns and cities will be better places in which to live. It needs investment but the costs, of poor health caused by inactivity which are currently £4billion annually, mean the potential savings are huge."
Martin Gibbs, Policy and Legal Affairs Director at British Cycling, added: "We're truly world class in sporting terms and more and more people are riding bikes but to make a step change in every-day cycling one of the decisions we need to make is that cycling will be built into our transport infrastructure and policies."
You've only got to look at some of the Cycle "Super"Highways in London for the best and worst of it. Some of the sections of CS3 (Barking to Tower Bridge) are absolutely dreadful - see the section in and around East India for some of the worst
I swear The blue paint makes the tarmac more slippery in the wet as well.
I avoid it - there's some big fat bus lanes on the A13 that provide a far more pleasant route to Docklands from Aldgate/Tower area
posted by VeloPeo [264 posts]
13th February 2013 - 9:46
Please read the following in the voice of a Hollywood movie trailer guy: Chris Boardman stars, in the Academy Award nominated adaptation, of the bestselling book of our times, authored by the renounced Warrington Cycle Campaign, BCF Stuidios is proud to present, "Crap Cycle Lanes: The Movie". Co-starring some mossy tarmac, a patch of frost, and two badly placed road signs. Featuring the voice talents of squealing brakes and clicking gears. Coming to a browser window near you...
Seriously, it's a nice effort to depict what is wrong with almost all bike lanes in this country. But I'm afraid that there are plenty of people who think that if it gets the bloody cyclist - who is adding an extra two seconds to their journey, or forcing them to think about their driving - off "their" road, then paths like that are fine. If they could have rigged it so that he encountered a dog on the path, that probably would have elicited more sympathy in many people (for the dog, not the Lycra lout who might run it over.) Still, Chris Boardman is an Olympian, and people care about that. And it might avoid the usual response when ordinary cyclists post videos of their commutes on line. Which is typically hundreds of vitriolic and uninformed comments about "road tax", and how the lack of any visible hand signals means the rider is clearly incompetent, and that unless they post their entire journey from door-to-door then how can we know they didn't jump any red lights in the bits they edited out.
posted by ubercurmudgeon [168 posts]
13th February 2013 - 9:51
posted by a.jumper [830 posts]
13th February 2013 - 9:52
Apart from stopping and starting the movie a couple of times before realising it wasnt buffering, it was good.
We all know cycle lanes are for convenient delivery van parking and that advanced stop boxes are for cars to get ten feet closer to the lights.
posted by lolol [171 posts]
13th February 2013 - 10:12
Very good. Maybe Chris could suggest that Liverpool City Council address cycle links in the city - before accepting 1,000 free Boris bikes? They would be better off spending £2.5M on making available routes safer for existing cyclists.
Joined up thinking is the key. LCC recently spent money replacing a quarter mile section of 10 foot wide pavement on Regent Road where no one ever walks. The whole road could be used to link the Sefton coastal cycle path to Liverpool city centre at Mann Island. Instead commuting cyclists risk their lives on Derby Road's dual carriageway where motorists habitually flaunt the 30 mph speed limit and the Police only set speed traps twice a year: once in summer when it's warm and again at Christmas when they need to get their drink driving tally up.
It's so blindingly obvious it makes me weep.
Silly me. You're probably right....
posted by MercuryOne [1197 posts]
13th February 2013 - 10:27
A good, unbroken example of poor cycling road markings. As another contributor has mentioned the blue painted cycle routes are effectively skid pads in wet or frosty conditions.
My pet hate of cycle lanes is the detritus and debris that is regularly strewn across them, in much the same way that it ends up on the hard shoulder. But even there it gets cleared up, whereas everything from tyres to broken glass ends up in a cycle lane and never moves. Road cleaners seem to ignore them.
Ultimately cycle lanes are set up so that it separates slow moving traffic from faster moving traffic (and pedestrians).
posted by Colin Peyresourde [1582 posts]
13th February 2013 - 10:28
One needs to question the education/knowledge and qualifications required to become part of the "planning" of such nonsense as the average cycle lane.
onward ever onward
posted by bikecellar [261 posts]
13th February 2013 - 10:34
just in case anyone's appetite has been whetted for more examples of often frankly comical cycle lanes then you need to check:
posted by joemmo [1096 posts]
13th February 2013 - 10:46
posted by Francois [9 posts]
13th February 2013 - 11:04
quite simply things have been done on the cheap in the hope to placate the masses, but now we are starting to actually use them, its shown its (mostly) an embarrassment and token efforts of a using a paint brush, than an actual INFRASTRUCTURE of cycling/public transport.
posted by a_to_the_j [114 posts]
13th February 2013 - 11:11
Excellent Video, but he should have filmed it near where I live (only about 10-12 miles from Chris)
The dual carriageway was recently re-surfaced, and during that they lengthened a slip-road, removing about 100-yards of *dedicated* cycle path. On the other side of the carriageway they did nothing to the cycle path there. There is no surface left on it. It certainly isn't passable on a road bike. It wouldn't have hurt to re-surface that too. Its a very busy road, and being forced to cycle on it, is not very pleasant at all.
Some Drivers are just idiots, I was passed one morning by some guy who was speeding on that particular road, with no attempt to slow down, even though there was on-coming traffic. it was terrifying.
That said, some cyclists need a lesson in road use too. the number of cyclists in manchester (where i work) who just ignore traffic signals is unbelievable!
posted by SpaceFlightOrange [6 posts]
13th February 2013 - 11:24
Can't someone give Norman Baker's job to CB?
Pretty please?
Pete Clinch
often seen riding a bike around Dundee...
posted by pjclinch [75 posts]
13th February 2013 - 12:05
I'd love to know how much money Councils have scammed of the UK Gov/European Grants to develop safer cycling in inner cities to find the grant money gets spent else where.
posted by Roberj4 [208 posts]
13th February 2013 - 12:34
It also illustrates the common lack of signage of cycle lanes in advance of where they start. For anyone riding a road bike at a mid-teen mph, spotting a cycle lane and evaluating whether it is cyclable before passing its entrance can be quite difficult. Once you have missed the start of it, getting onto it usually means stopping and lifting your bike over a kerb or verge.
As others have noted above, it is then likely to be uneven and litter and obstacle strewn, before disgorging you back into the traffic, again with little warning.
posted by Bexleyhillbilly [47 posts]
13th February 2013 - 13:03
good video from Chris Boardman, so many cycle lanes I pass are almost always blocked by vehicles, lamp posts, rubbish, rough surface unsuitable for a road bike or only last for a few metres so are useless. When I do get to make use of a cycle lane, it always has all the gunk and debris that is normally on hard shoulders or central reservations, one I use often is covered in tree branches, not the best when you want to do all you can to avoid having a dreaded puncture on the way to/from work!
posted by ridetheroad123 [7 posts]
13th February 2013 - 13:21
I wish he could of made a film on my nearest cycle path. Along a long straight main road, but the cycle path goes on oneside for about 200m, then you have to cross the road using a Toucan crossing before having to cross back again 200m later, and at the end the path it ends on a roundabout with you on the wrong side facing traffic!
posted by Darren C [92 posts]
13th February 2013 - 13:40
Great video showing exactly why I think bike lanes should be scrapped. The ones shown here only go to emphasise the separation of bicycles from motorised vehicles. So the line gives the car driver the excuse of passing close because they are "in their lane". And, of course, in this case where the lane carriageway becomes too narrow to support the bike lane they just throw it away, rather than narrowing the car lane.
And a final question might be, what is a cyclist wanting to turn right at the roundabout supposed to do? Go on the bike path and cross 4 lanes of traffic to do so? I don't think so.
If you feel confident enough ride on the road. Use th cycle paths if you don't. But it might not be safer, or easier.
posted by akmbikes [10 posts]
13th February 2013 - 14:10
there was a guy injured nearby recently on a completely segregated cycle path where someone has placed a speed limit sign for the road traffic bang in the middle of the bike lane. It was dark, he didnt see it, he ended up in hospital with a broken arm.
posted by joemmo [1096 posts]
13th February 2013 - 14:33
there was a guy injured nearby recently on a completely segregated cycle path where someone has placed a speed limit sign for the road traffic bang in the middle of the bike lane. It was dark, he didnt see it, he ended up in hospital with a broken arm.
So the sign wasn't reflective and/or he didn't have a front light...?
Sign shouldn't have been there, but something doesn't quite add up.
posted by Simon_MacMichael [9387 posts]
13th February 2013 - 14:41
I've seen it all now - proof that even the great Chris Boardman rides on the pavement!
In an article by British Cycling they ask that you send them images of other crap 'facilities' or upload video:
I might have to finally get round to recording the disjointed, pathetic cycling infrastructure in Shrewsbury.
posted by Simon E [2375 posts]
13th February 2013 - 15:03
That pretty much sums up cycle path experience for me. A well thought out and put together video.
posted by eddgould [12 posts]
13th February 2013 - 16:20
You forgot the black cab driver shouting "GET IN THE BLOODY CYCLE LANE!"
posted by londonplayer [671 posts]
13th February 2013 - 16:33
As someone who regularly cycles in greater Liverpool, I must admit that this pretty much resembles what I see day in day out when riding. Or at least it does when I'm not fighting to avoid potholes, maintain a line on poorly maintained roads, and have to deal with the odd inconsiderate driver for good measure. Back home in Trafford, its even worse, as there are pot holes in pot holes in the cycle lanes, and seemingly more inconsiderate drivers then here.
posted by pdows47 [110 posts]
13th February 2013 - 17:47
joemmo wrote:someone has placed a speed limit sign for the road traffic bang in the middle of the bike lane. It was dark, he didnt see it, he ended up in hospital with a broken arm.
So the sign wasn't reflective and/or he didn't have a front light...?
Sign shouldn't have been there, but something doesn't quite add up.
I'd expect his front light was dipped, so as not to dazzle drivers, so didn't light the sign itself because it was in front of him, not to the left, and it was mounted on a non-reflective dull grey post like those in Chris Boardman's video. Easily done and all too common. Some councils even prefer black posts
posted by a.jumper [830 posts]
13th February 2013 - 18:38
Getting more people to cycle isn't rocket science, it is really very simple, so how come the people we elect to lead our country just don't get it?
posted by Kim [201 posts]
13th February 2013 - 20:45
It just go's to show that British Cycle lanes are often implemented by non cyclists with the aim of getting the bike out of the way of the cars rather than making a space on the road for cyclists.
posted by Fixedwheelnut [20 posts]
13th February 2013 - 23:46
Outside Geoffrey Butlers in South Croydon. Every metre counts towards the councils cycling infrastructure targets. Nice Brazilian colours scheme though!
posted by robert_obrien [120 posts]
14th February 2013 - 10:42
posted by Arno du Galibier [45 posts]
15th February 2013 - 11:57
Great video showing exactly why I think bike lanes should be scrapped.
Exactly this.
posted by andyp [1368 posts]
15th February 2013 - 12:04
I'd love to know how much money Councils have scammed of the UK Gov/European Grants to develop safer cycling in inner cities to find the grant money gets spent else where.
That would make a great Freedom-of-Information request!
posted by Pub bike [128 posts]
3rd December 2013 - 18:00


text:
Edward WestonAmerican (Highland Park, Illinois, 1886 - 1958, Carmel, California)
ca. 1917photograph | gelatin silver print
Not on view at this time; find out where you can see works from our collection at locations around the Bay Area while our building is closed for expansion
7 1/4 in. x 8 5/8 in. (18.42 cm x 21.91 cm)
Acquired 2012
Collection SFMOMA
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© 1981 Center for Creative Photography, Arizona Board of Regents

subset: commoncrawl


text: Close Tweet0 Share0 Comment0 Share0 Share0 Stumble It0 Print0 More Point Forward Metta World Peace suspended for striking Brandon Knight by Rob Mahoney Twitter Email Posted: Tue Feb. 5, 2013 http://www.youtube.com/watch?feature=player_embedded&v=ggRtTIwuYigBy Rob MahoneyMetta World Peace continues to find new and exciting ways to warrant league-issued suspensions.According to an NBA release, the Lakers forward will suffer a one-game penalty for an incident that took place on Sunday between World Peace and Pistons guard Brandon Knight. On the play, Knight had the misfortune of drawing World Peace on a box-out, and the two tussled for rebounding position. Shortly after, World Peace pulled Knight by the neck and appeared to give the much smaller Piston a quick jab to the chest, though due to the proximity of the players it's difficult to pinpoint exactly what transpired.At the time, World Peace was assessed with a flagrant 1 foul following a lengthy video review, though the NBA's disciplinary officials have apparently seen fit to take further action. The release clarifies that World Peace was suspended on the grounds of "... grabbing [Knight] around the neck and striking him in the jaw," and that he will serve his one-game term during Tuesday night's game against the Brooklyn. That complicates things for the playoff-hopeful Lakers, who will take on a solid Nets team without two of their top three players (Dwight Howard will also miss the game with persisting shoulder pain) in terms of minutes per game. Video H/T: Eye on Basketball. Promoted Stories Comments


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Why Humans and Animals Create NetworksWhen: Monday, February 11, 2013 at 3:00 pm
Where: DA 114
Speaker: Lazaros Gallos
Organization: Research Associate, Department of Ecology, Rutgers University
Sponsor: Physics Colloquium
Advances in network theory have provided novel insights on how people are connected. We now have a good understanding of the robustness of social networks and spreading processes. The question of why we create networks, though, is still largely answered by qualitative sociological theories. I will present a quantitative analysis of empirical evolving networks, that allows to detect the social mechanisms used for online connections. This information cannot be extracted by the study of static network snapshots. The presented analysis can detect different trends according to gender, age, etc.
Similarly to humans, animals create their own social structures. Different species organize themselves in distinct social structures. Are there any hidden attributes that can help us predict how these networks will be shaped? Is it possible that the structure is dictated by external influences? I will discuss how social networks of different species can evolve to be similar to each other, according to the influence of external non-genetic factors.


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December 31, 2007
Happy new year!
December 17, 2007
On developing finstall
I've got several queries on finstall development, so here's a few words on the subject. The development has moved to SourceForge.net. The move was made to enable users that don't have FreeBSD.Org accounts to participate in development. The source code repositories are world-readable. If you're interested, contact me and I'll add you to the project as a developer.
One part of the project that will be interesting to many people is the LiveCD ISO-building script, makeimage.py. There's currently no documentation on it, but its command-line argument are well explained. This script could be useful to people wanting to create their own LiveCD.
December 10, 2007
finstall alpha2
I've created a new livecd+finstall ISO image containing FreeBSD 7.0-BETA4. This release of finstall fixes most of the bugs present in earlier versions, and introduces only one new feature: file systems are created on glabel devices. You can fetch the alpha2 version of finstall here. It was good to get back to this project, even in the limited time i have for it.
It looks like I can now create a realistic schedule for 7.0-RELEASE. It will probably contain the following new features (i.e. in addition to those already in alpha2):
* Installing on already partitioned drives
* Some kind of rudimentary remote install.
Yes, this means that software RAID and volume management support will not get in there for this release, but there really wasn't time as I spent most of the time (during and post SoC) chasing bugs in the kernel (and, as it turns out, the compiler). I hope I'll have support for sw RAID and VM for 7.1-RELEASE.
I'd appreciate bug reports, and also help from interested developers. One field when it definitely needs work are text strings: language proofing, help texts, etc. I18n is not yet supported – only English is used now.
In case you missed it, here's what's new in FreeBSD 7.0.
December 7, 2007
WINE on FreeBSD
For those not following the mailing lists, here's some encouraging news about running Windows applications on WINE on FreeBSD 7:
* MS Office 2000
* 3D benchmark
It seems that benchmark results are a bit lower (less than 10%) for FreeBSD, compared to Linux.


text:
Marvel has finally given us our first look at The Avengers. Well, I guess we've seen all of them before in their own solo movies. But now we have a look at them hanging out together. Except it's actually the second time we've seen them bro out if you count the mini-trailer that aired after the Captain America end credits.
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When you're done gawking at the trailer, click here to gawk at 27 Hot Girls Dressed Like R2D2.
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I'm planning on doing a thru hike this year and stuck on base layers. Originally I was going to just go with wool, something like a 185 weight top and bottom. However, I have started looking at the MECT T2 zippered top (bottoms no longer available online) or the REI baselayers both made out of Power Dry. My interest is due to some of the high praise I've read for power dry on this site.I'm worried about getting too warm a baselayer and sweating out and of course too light and freezing at night. Right now I do plan on taking hiking pants from San Diego thru the Sierras for sun protection and warmth.Any other recommendations? Thanks, in advance.
Southern CA is hot and sunny. Northern CA is hot and sunny, too. Get something with good SPF. Between the border and KM, you'll see very little tree cover and tons of sun. Even if you don't burn easily, that much sun is not good for you.I wore a l/s nylon shirt on my thru and would definitely do so again. Bugproof, high SPF (like 50), and it dried fast enough. Also mostly smell-free (at least compared to synthetics). For me, PowerDry would be insanely hot. I think even 185-weight wool might be too hot. Don't base your hiking shirt weight on sleeping--if you're cold at night, bring a better sleeping bag or a warm layer to sleep in. You don't want to be overheating all day long just to stay a little warmer at night.
I wouldn't worry about a baselayer being too light/cool. Too hot sucks, but too cool and you always just toss another layer on, such as a windshirt.I'm thru hiking the PCT this year. I'm starting with a long sleeve nylon button up shirt (Patagonia Gone Again) for sun protection., and then a short sleeve light nylon baselayer (GoLite Wildwood Run Top). I can wear both or either one at a time. Once I hit the Sierra's I plan to switch out the button up nylon shirt for a nylon windshirt (MEC RD) because it seals up better if needed to block bugs.
base layers are not needed for hikinginstead +1 on a thin, long sleeved, nylon shirtmany brand names to choose from such as Patagonia, Ex-Officio, etcor go to your local thrift store and pick up a simple men's nylon dress shirtsome people bring a set of baselayers for pyjamas and extra warmth around camp at nightin that case the material used is not important
It depends on what you are using a base layer for. I don't like using them to hike in unless its cold as I prefer loose thin clothing when hiking in sun. And on the PCT, you will be doing a lot of hiking in the Sun even in the pacific northwest. There is a reason the PCT has so many views. This isn't the AT where you are hiking in a dense green tunnel in shade.I sleep warm and I've found that my body generates a good amount of heat, especially if I hit a climb while hiking. As such, on the PCT I found that a lightweight baselayer was all I needed for sleeping at night in below freezing weather with a 20F down quilt. And for hiking in cold predawn morning or the snow I had just before Canada under my normal hiking clothes with maybe a rain jacket. I did have a 6oz down jacket for wearing around camp, but never hiked in it (too hot) or slept in it (it was my pillow). Your mileage may vary.So anything by Marmot, Patagonia or any other major brand that says lightweight/silkweight should do unless you are just a cold person to begin with. Though you likely won't make many friends being that way. ;-)By the way, southern California may be hot during the day, but it can be below freezing at night. The lack of humidity means there is no moisture to hold the heat when the sun goes away. I actually found Northern California to be hotter (except for the San Gorgonio Pass by the I-10) than Southern California during both the day and night time.
Edited by Miner on 02/28/2014 14:24:00 MST.
I bet the T2 would be a good layer to have later in your hike depending on when you finish. My medium T2 hoody is 6.5 oz. Pair that with a light LS synth or wool shirt & you've got a lot of base/miflayer versatility for not a lot of weight. If you're set on having a pair of sleep clothes, the T2 would do well for that, but for sure a light airy layer with good sun protection, like others have said, will be a better go to hiking layer.
I would go with something along the lines of Patagonia Capilene 2 or maybe 3. I typically only used my baselayer while hiking on cooler mornings or evenings. I did wear it one some rare days when temps dropped and the snow started falling. I also wore it all the way up Whitney. Mine ended up getting about as much use as my rain jacket (almost none).
To be honest, I just kind of planned of taking a top and bottom base layer the entire trip, but you guys have me rethinking that. My hiking experience is very limited, I have traditionally been more of a "camper"How would this sound then:L/S Nylon shirt (dont' have yet)S/S leightweight wool or synth t shirt running shorts with liner like the mesa trail shortsnylon pants (don't have yet)BD Alpine start hoodie (already have it)MH Gost Whisperer jacket w/ hood (already have it)Possibly add L/S baselayer and/or pants for the sierras and later on in Washington (Northern Cascades)I'm just a little confused what I would sleep in though. Wouldn't I want to take the L/S nylon shirt and hiking pants off at night to let them air out?I have a 20degree quilt, borah gear bivy and hexamid solo plus for more information.
On long hikes, I usually carry a spare t-shirt for sleeping in and for town. On the PCT, I actually slept in my hiking short a lot of days. It was dry enough that even if I was sweaty when I got into camp, I was dry by the time I went to bed. But I also had a silk bag liner to keep my sleeping bag clean.As for jackets, I don't think that the BD jacket is really waterproof (or is it?). Some people don't bother with a rain jacket for southern CA, but I would not leave Campo without one. You'll definitely want a real rain jacket for OR/WA and probably for the Sierra.
most likely driduk starting out in addition to what I have listed above
You really don't need that many layers. I carried the clothing that I hiked in the entire time for sun protection and then I carried a couple of layers for resting or bad weather.I hiked in convertible pants for sun and leg protection. I rarely converted then to shorts, but the zippers were nice for venting. I hiked in a long sleeve button down shirt from Mountain Hardware that was designed for desert travel. I rolled up the sleeves when I got too hot.Also carried: sun gloves, light wool hat, rain jacket, windshirt, extra socks, light down jacket, fleece mittens (used in so cal just as much as the sierra!), sun hat, base layer top. I don't think I carried base layer pants. I also picked up a cheap pair running shorts just to wear while doing laundry.On the first day you will climb from a small creek bed up a decent sized hill before you reach Lake Morena. You will probably reach it when the day is hottest. I saw a small pile of junk that someone ditched. Included was an extra pair of shorts and a short sleeve shirt. Think really hard if you want to carry a change of clothes for 2000+ miles.
bundyloco, you might enjoy reading this 4 part series Hiking Through Hyperbole: The Vortex of Fear , it includes a gear list and how it changed throughout the trip.
as to the T2/cap4 it tends to be a cooler weather layer, especially if you are wearing it under somethingsomething to consider ... remember that you can always add layers, but you cant take away ones that are too warm if they are our base;)
I wore a single long sleeve base layer the whole PCT. it was at the time the absolutely lightest weight synthetic I could find, Golite BL-1. Thankfully I bought two since they no longer make them. Also, I believe color matters. I went with white, which soon became somewhat dingy brown, to reduce the amount of absorbed heat. I would take that shirt again if I were heading again to Campo.PS. You can't get too light. Your base layer should be uber quick drying. If you get cold put on a wind shirt or insulating layer. I don't believe a base layer should be used for warmth
Edited by gg-man on 03/01/2014 05:53:02 MST.
I use some lightweight shorts, Patagonia gi3 even when it's cold. They have a belt and two zippered pockets. I am not a fan of pants unless it's snowy winter. If needed I still bring merino baselayer bottoms and wear then under my shorts if it's a cold morning or at night in camp. Shorts are about 8oz and tights are 5oz. From there I usually bring a 8oz puffy. Right now I have a 2oz wind shirt and I bring a 2oz disposable poncho for rain. If I were to add warmth I would look for a wool hoodie at about 8oz.
Danskin makes some really nice lightweight long sleeve shirts, seven or eight bucks at Wally World and they work great for summer base layers.
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TRON: Evolution Battle Grids for Nintendo Wii is an action-packed game set in the combat arenas and cities of the TRON universe. Battle, race, and play combat games to become the ultimate Grid Games Champion as you experience the world of TRON in the game inspired by the highly anticipated film, TRON: Legacy.
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text: http://forum.xda-developers.com – INSTRUCTIONS: 1.Download install as a normal apk. 2.run the Xperia Motion Snap from your apps menu. To use a video as live wallpaper, you can either start recording a video then set it as wallpaper, or you can save it, then apply it by selecting Xperia Motion Snap in Live Wallpapers from the homescreen (long press homescreen → select Wallpaper). APK Say thanks here OP (HowTos)


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Puppy Playdate!
Tuesday, May 14, 2013 -
11:00am to 2:00pm
Northwest Patio, Markee Pioneer Student Center
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Stressed out about finals? Come take a break at Puppy Playdate! CPR is bringing four therapy dogs from the Dubuque Regional Humane Society to campus to help you survive finals week. Stop on over for some downtime with the dogs.
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'Gint' in Appalachia
UWM students stage a life's immensity in a studio theater
UWM instructor Jim Tasse directs the drama, which stars two different students in the title role. In act one, we see Glenn Widdicombe in the role. Widdicombe has a sinewy, precise stage presence that should be interesting in the ragged end of the role. At the tale's beginning, we see a man of ambition limited by his own actions, which involve lying, drinking and various sexual misadventures. In act two, Michael Jeske plays Gint as a 75-year-old billionaire who has compromised much and looks to found a new country based entirely on corporations. Widdicombe, Jeske and a host of other actors hope to bring the immensity of one life into the humble confines of a studio theater.
Gint runs Dec. 4-8, at Kenilworth Studio 508, 1925 E. Kenilworth Place. For tickets, call 414-229-4308 or visit arts.uwm.edu/tickets.
Theatre Happenings
Sunset Playhouse brings James W. Rodgers' adaptation of the Frank Capra classic to the stage this holiday season as it presents It's A Wonderful Life, Dec. 5-31, in its theater space at 800 Elm Grove Road. For tickets call 262-782-4430 or visit sunsetplayhouse.com.
The popular comic wedding theater show, Tony & Tina's Wedding, will descend on Turner Hall Ballroom, Dec. 5-14. The dinner-and-a-show in a wedding reception format has appealed to audiences for decades. For tickets, call 414-286-3663 or visit pabsttheater.org.


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Best of News
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A woman with her dogs in a polling station in the center of Rome on... Fotografía de noticiasAdulto,Centro electoral,Democracia,Elecciones,Elección general,Estación,Horizontal,Italia,Mujeres,Perro,Política,Roma - ItaliaPhotographer FILIPPO MONTEFORTECollection: AFP 2013 AFPA woman with her dogs in a polling station in the center of Rome on February 24,2013 during Italy's general elections. Italians fed up with austerity voted on February 24 in the country's most important election in a generation, as Europe held its breath for signs of fresh instability in the eurozone's third economy. AFP PHOTO / FILIPPO MONTEFORTE (Photo credit should read FILIPPO MONTEFORTE/AFP/Getty Images)


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Bowling Green, Ky. — The Western Kentucky University football team will not waste any time challenging itself as it begins a two-year transition period to the NCAA Division I-A (Football Bowl Subdivision) level, as the Hilltoppers will open the 2007 season with a game against defending national champion Florida on Sept. 1.
That will be the first of 12 contests for the Toppers in the fall, with half of those coming against other NCAA Division I-A schools. That includes three match-ups against future Sun Belt Conference opponents.
WKU's game against UF — a 41-14 winner over previously top-ranked Ohio State in the BCS National Championship Game in January — will mark the second time in as many years that the Hilltoppers will begin the season at a Southeastern Conference school after facing Georgia to kick off the 2006 campaign. The Tops have also played Auburn twice since 2003 as well.
The Toppers will open a three-game road stretch, all against FBS opponents, with a Sept. 20 (Thursday) date at Middle Tennessee. It will be the 58th meeting between the two schools, but first since 1991. WKU will also take on Mid-American Conference members Bowling Green on Sept. 29 and Ball State on Oct. 13 during that stretch.
And, the Hilltoppers will play host to Troy — last year's Sun Belt champion and winner of the 2006 New Orleans Bowl — on Nov. 10 while closing out the season Nov. 24 at North Texas.
"We were looking for a balanced schedule as we began the transition, and I think we have been able to accomplish that with six games against Division I-A opponents," said Dr. Wood Selig, WKU Director of Athletics. "We're excited that the defending Sun Belt champion will be visiting Bowling Green — I think that is a positive sign in regards to the types of schools we will be able to play at home once we have completed the transition. With the competition we've lined up for this fall, our fans can look forward to seeing WKU play an annual schedule that includes some of the best teams not just in the region, but in the country."
The Tops will face West Virginia Tech Sept. 8 in the first of five home games in the fall, while the 84th edition of the "Battle of the Bluegrass" against Eastern Kentucky will take place the following Saturday. North Carolina Central will visit Smith Stadium on Oct. 27, with Morehead State the opponent on Senior Day Nov. 17.
Other WKU road games include trips to Indiana State on Oct. 20 and Chattanooga on Nov. 3.
All game times will be announced at a later date.
"We are excited about our 2007 schedule. This is obviously the most challenging schedule in the history of WKU football with six I-A programs as well as the six non-I-A schools that are all quality programs," Topper head coach David Elson said. "These are both historical and changing times for WKU football. Our staff and players are extremely excited about leading the program into the future as a I-A institution and look forward to seeing our fans at Smith Stadium this fall for five exciting home games highlighted by "The Battle of the Bluegrass" as well as defending Sun Belt Conference champion Troy.
"It will be an exciting atmosphere as we unveil our new state-of-the-art video replay scoreboard, and as we literally see the new side of Smith Stadium rise out of the ground as we raise our program to new heights at the I-A level."
The Hilltoppers begin their transition period having posted a winning record 11 years in a row after concluding the 2006 season with a 6-5 mark. They will be eligible to compete for the SBC title and a bowl berth beginning in 2009.


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Pasig City, Philippines
This iReport is part of an assignment:
What are you watching?
Biggest Loser Philippine Edition Grand Finale
The Grand Finale of the first season of The Biggest Loser *Pinoy Edition was held tonight, October 8, 2011 (Manila Time) at the Ynares Sports Arena in Pasig City.
Larry Martin (picture #3), a wildcard contestant, was held as the very first Pinoy Biggest Loser with a total weight loss of 101 pounds from his starting weight of 255 pounds, or 39.61% total weight loss percentage. Larry took home 22,878USD (PhP 1,000,000), a codominium unit, a scooter, a 40-inch Sony Bravia Internet TV, Whirlpool appliances and a lifetime gym membership from Fitness First. Larry will also be the coverboy for the November issue of Men's Health Philippines. The other four finalists received 11,439USD (PhP 500,000) each
"Martin was a police officer in Camarines Sur, but was relieved from his post for failing to meet the 34-inch waistline limit," according to ABS-CBNnews.com.
Here is the total ranking of the Top Five Finalists:
- Larry – 39.61% (101 pounds lost)
- Art – 37.33% (129 pounds lost)
- Raffy – 34.37% (100 pounds lost)
- Angela – 33.8% (75 pounds lost)
- Hazel – 33.01% (68 pounds lost)
The Finale was also a trending topic on twitter (picture #5).
Complete Article: http://www.abs-cbnnews.com/entertainment/10/08/11/larry-martin-named-first-pinoy-biggest-loser
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Cliff looms: Kicking the Can, Washington-style
FILE – In this Friday, Dec. 21, 2012, file photo, speaker of the House John Boehner, R-Ohio, joined by House Majority Leader Eric Cantor, R-Va., left, speaks to reporters about the fiscal cliff negotiations at the Capitol in Washington. Lawmakers probably could enact a compromise quickly and easily if Republican leaders let Democrats provide most of the votes. By trying to pass his plan with GOP votes alone, Boehner could afford to lose only two dozen of the 241 House Republicans. His private head-count found nearly twice that many defectors, party insiders say, forcing Boehner to give up without seeking a formal vote. (AP Photo/J. Scott Applewhite, File)
WASHINGTON (AP) — When it comes to the nation's budget challenges, congressional leaders are fond of saying dismissively they don't want to kick the can down the road.
But now, a deadline hard ahead, even derided half-measures are uncertain as President Barack Obama and lawmakers struggle to avert across-the-board tax increases and spending cuts that comprise an economy-threatening fiscal cliff.
Congressional officials said Wednesday they knew of no significant strides toward a compromise over a long Christmas weekend, and no negotiations have been set.
After conferring on a conference call, House Republican leaders said they remain ready for talks, urged the Senate to consider a House-passed bill that extends all existing tax cuts, but gave no hint they intend to call lawmakers back into session unless the Senate first passes legislation.
"The lines of communication remain open, and we will continue to Login to read more
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Epithelial-mesenchymal transition of tubular cells is a widely recognized mechanism that sustains interstitial fibrosis in diabetic nephropathy (DN). The signaling of FGF-2, a growth factor involved in this mechanism, is regulated by glycosaminoglycans. Heparanase-1, an endoglycosidase that cleaves heparan sulfate, is implicated in the pathogenesis of diabetic nephropathy and is necessary to FGF-2 for the induction of tubular cells transition. Well known Heparanase-1 inhibitors are heparin(s) and sulodexide, a low-molecular weight heparin – dermatan sulphate blend, which is effective in the treatment of DN.
We have investigated the inhibition by sulodexide and its components of Heparanase-1 by an ELISA assay. We have analyzed its effect on the epithelial-mesenchymal transition of tubular cells by real time gene expression analysis, zymography and migration assay.
Results show that sulodexide is an effective heparanase-1 inhibitor, exclusively in virtue to the heparin component, with an IC50 of 5 μg/ml. In FGF-2 treated tubular cells, sulodexide also prevents the over-expression of the mesenchymal markers αSMA, vimentin and fibronectin and the motility increase, i.e. the epithelial-mesenchymal transition of tubular cells. Moreover, sulodexide prevents FGF-2 induced heparanase-1 and MMP9 increase switching off the autocrine loop that FGF-2 activates to support its signal.
The findings highlight the capacity of sulodexide to inhibit heparanase-1 and to control tubular fibrosis triggered by epithelial-mesenchymal transition. In conclusion, these sulodexide activities support the value of this agent in controlling the progression of nephropathy to renal failure.
Keywords:Diabetic nephropathy; Epithelial-mesenchymal transition; Fibrosis; Heparanase-1; Sulodexide; Tubular cells
Diabetic nephropathy (DN) and several other chronic kidney diseases are characterized by tubular and interstitial fibrosis, which are primarily responsible for accelerating the progression to end-stage renal disease (ESRD)[1-3]. The epithelial-mesenchymal transition (EMT) of tubular epithelial cells is a process that sustains these events [4,5], and it is triggered by many factors [6-9]. A recent work of ours highlighted the central role of FGF-2 in EMT. Heparanase-1 (HPSE) is needed for EMT and by regulating syndecan-1 (SDC1) and MMP9 it sustains the FGF-2 autocrine loop [10]. HPSE is an endo-β-D-glucuronidase that cleaves heparan sulfate (HS). It takes part in extracellular matrix (ECM) remodeling and degradation, regulating the release of many HS-bonded molecules, such as growth factors, chemokines, cytokines, and enzymes, that are involved in inflammation, wound healing and tumor invasion [11,12]. A body of literature supports the involvement of HPSE in the pathogenesis of proteinuric disorders, including DN [13-15] and that is why there is great interest in identifying effective HPSE inhibitors capable of controlling mechanisms of renal damage such as EMT. The best-characterized HPSE inhibitors are low-molecular-weight heparin (LMWH) and its derivatives [11]. Previous studies have shown that sulodexide (a highly purified glycosaminoglycan [GAG] isolated from porcine intestinal mucosa, used since 1974 as an antithrombotic drug) can control proteinuria and podocyte damage by inhibiting heparanase [16-18]. Sulodexide consists for 80% of LMWH and for 20% of dermatan sulfate (DS). The heparin fraction has a molecular weight of 7000 D and a low degree of sulfation. DS is a polydisperse polysaccharide with an anticoagulant and antithrombotic activity. The treatment of DN demands additional therapeutic strategies because strict glycemic control may prove difficult to achieve in diabetic patients and, even if patients respond to conventional therapy with ACE inhibitors, kidney fibrosis slowly continues to progress and eventually leads to renal failure. It has been demonstrated that sulodexide and heparin-derived drugs are effective in the treatment of DN [19,20] and it has recently been suggested that in a rat model of peritoneal dialysis sulodexide prevents EMT in the peritoneal membrane [21]. The aim of this work was to investigate whether sulodexide inhibits HPSE, and whether this mechanism can prevent FGF-2-induced EMT in renal tubular cells. If so, sulodexide would be an interesting agent for controlling renal fibrosis and the progression of nephropathy to ESRD.
Heparanase assay
Twenty-five μl of matrigel (Matrigel™ Basement Membrane Matrix) at a concentration of 200 μg/ml were placed in the wells of a 96-well plate for ELISA and left to dry under an extractor hood at room temperature for 90 minutes. Test samples were prepared by mixing different concentrations of the GAGs being tested with heparanase (stabilized and lyophilized HepaOne TM Recombinant Human Haparanase-1 [rhHPA1]- InSight Biopharmaceuticals). The following GAGs were tested: sulodexide (Alfa Wassermann), the LMWH parnaparin (Alfa Wassermann), a commercial dermatan sulfate (DS) from Sigma (Sigma Aldrich C-3788), and the LMWH H2046 and dermatan sulfate D2047 (Opocrin). H2046 and D2047 are the two ingredients in sulodexide, from which they were obtained by affinity chromatography. The wells containing the matrigel were washed once with PBT (PBS+ 0.05% Tween 20) before adding the samples of enzyme/inhibitor, 25 μl per well, in working buffer (50mM Tris-HCl pH 5; 150 mMNaCl; 0.01% Triton X; protease inhibitor [complete, Roche Diagnostics]) and incubating overnight at 37°C. The heparanase enzyme was used at a concentration of 0.5 ng/μl. Each GAG was tested at four concentrations (5, 10, 20, 50μg/ml). Different GAG mixtures were tested, consisting of parnaparin with DS, and H2046 with D2047, in proportions of 20:80, 50:50 and 80:20; all GAG mixtures were tested at the same concentrations. As positive control wells were incubated overnight in working buffer.
After aspirating the treatment medium and washing with PBT 200 μl per well, the wells were saturated with blocking buffer (PBT; 0.5% BSA; 1mM EDTA) and left for 2 hours under agitation at room temperature. The blocking buffer was aspirated and the wells were washed twice with PBT. Then the samples were incubated with the primary anti-HS antibody (mouse IgM) Clone HepSS-1 (Seikagaku), 25 μl per well, diluted 1:500 in blocking buffer, for 1 hour under agitation at room temperature. Three washing cycles lasting 5 minutes each with 200 μl of PBT per well were followed by incubation for 1 hour with the secondary antibody, goat anti-mouse IgM-HRP (sc-2973, Santa Cruz Biotechnology) 25 μl per well, diluted 1:1000 in blocking buffer, under agitation at room temperature. After a further 3 washes lasting 5 minutes each with 200 μl per well of PBT, 50 μl of the ABTS (2.2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) liquid substrate system for ELISA (Sigma) was added to each well and the plate was kept in the dark for 15 minutes, then the reaction was blocked with 50 μl per well of 1% SDS (sodium dodecyl sulfate). The absorbance was read at 405 nm. The percentage of residual HPSE activity was calculated as follows: (max degradation – OD405 sample)/ max degradation *100.
Where max degradation = OD positive control - OD 0.5 ng/μl of heparanase in working buffer. (the addiction of GAGs at working buffer do not modify the maximal HS signal).
Cell cultures
The human renal proximal tubular cell line, HK2 (human kidney 2), was grown in DMEM-F12 (EuroClone) (17.5 mM glucose) supplemented with 10% fetal bovine serum (Sigma Aldrich), 2 mM L-glutamine, penicillin (100 U/ml) and streptomycin (100 μg/ml), and maintained at 37°C in a 5% CO2 water-saturated atmosphere.
mRNA expression analysis
HK2 cells were grown to subconfluence, starved in serum-free medium for 24 hours and then cultured in serum-free medium with 10 ng/ml of FGF-2 (BD Bioscience) for a further 6 hours, with or without sulodexide (50 μg/ml). Total RNA was extracted from the cells using the "GenElute Mammalian Total RNA Miniprep" kit (Sigma Aldrich). The samples were further treated with DNase (DNASE70, Sigma) to prevent any DNA contamination. The total amount of RNA and its purity were checked using the Nanodrop (EuroClone) and 1 μg of each sample was reverse transcribed into cDNA using SuperScript II Reverse Transcriptase (Invitrogen) according to the manufacturer's instructions. Real-time PCR was performed on an ABI-Prism 7500 using Power SYBR Green Master Mix 2X (Applied Biosystems). A quantitative analysis was performed to assess the expression of fibronectin fibronectin (FN), vimentin (VIM), matrix-metalloprotease 9 (MMP9), alpha smooth muscle actin (αSMA), HPSE, SDC1. Results were normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression. The forward and reverse primer sequences have been reported elsewhere [10]. Gene expression was quantified by means of the comparative Ct method (ΔΔCt) and the relative quantification (RQ) was calculated as 2-ΔΔCt. Melting curve analysis was performed to check for any presence of non-specific amplification products.
Gelatin substrate zymography was carried out to assess the MMP-9 activity in HK2 cell conditioned media using standard procedures [22]. To obtain the conditioned media, subconfluent cells were cultured in serum-free medium for 24 h, then incubated with or without FGF-2 (10 ng/ml) and sulodexide (50 μg/ml) for a further 24 h. Equal amounts of conditioned media, obtained from the same number of cells, in sample buffer (4% SDS, 125 mM Tris-HCl pH 6.8, 20% glycerol and 0.05% bromophenol blue) were resolved in non-reducing on 10% SDS-PAGE gels copolymerized with 0.1% gelatin. After electrophoresis, the gels were washed twice for 30 min in 2.5% Triton X-100 at room temperature to remove SDS, then equilibrated for 30 min in collagenase buffer (50 mM Tris, 200 mM NaCl, 5 mM CaCl2 and 0.02% Triton X-100, pH 7.4), and finally incubated overnight with fresh collagenase buffer at 37°C. Gels were stained with 0.1% Coumassie Brilliant Blue R-250, 30% MetOH/10% acetic acid, for 1 hour and destained with 30% MetOH/10% acetic acid. Digestion bands were analyzed using the ImageJ software (http://rsb.info.nih.gov/ij/ webcite).
Migration assay
We evaluated the migratory ability of cells in the presence of FGF-2 (10 ng/ml), and with or without sulodexide, parnaparin or DS (50 μg/ml). Briefly, a denuded area was generated on a quiescent cell monolayer of HK-2 cells by scratching with a sterile pipette tip. The monolayer was washed twice with phosphate-buffered saline (PBS) and then incubated with medium (2% FBS) containing the treatments. The cells were photographed at different time points. The scratch was measured at three points in each photo to obtain a mean value. Migration was reported as the difference (in mm-1) between the dimensions of the scratch at the baseline and after 24 hours [23].
Sulodexide inhibits HPSE activity
Our data show that sulodexide 5 μg/ml is capable of producing a 50% heparanase inhibition; HPSE is inhibited completely with 20 μg/ml of sulodexide (Figure 1A). Since sulodexide is a mixture of LMWH and dermatan sulfate, we also analyzed the heparanase inhibiting effects of two different formulations of LMWH (parnaparin and H2046) and dermatan sulfates (DS and D2047). Parnaparin and H2046 completely inhibited heparanase at a concentration of 5 μg/ml, whereas both dermatan sulfates proved unable to reduce the enzyme activity by more than 30% at any concentration up to 50 μg/ml (Figure 1B).
Figure 1. Reduction of HPSE activity by sulodexide and GAGs. Histograms showing the percentage of residual heparanase enzyme activity after incubation with Sulodexide and GAGs at various concentrations ± SD. All experiments were performed three times in triplicate.
To see how the relative proportions of heparin and dermatan sulfate in sulodexide could contribute to its HPSE inhibitory property, we tested H2046 + D2047, and parnaparin + DS, both in proportions of 20:80, 50:50 and 80:20. The results showed that both the 80:20 formulations completely abolished HPSE activity at a concentration of 10 μg/ml (Figure 2 compares the results for parnaparin + DS versus sulodexide).
Figure 2. Reduction of HPSE activity by GAG mixtures. Graphs showing the percentage of residual heparanase enzyme activity after incubation with sulodexide and parnaparin + DS in proportions of 20:80, 50:50 and 80:20, at concentrations of 5, 10, 20 and 50 μg/ml ± SD.
Sulodexide prevents any increase in mesenchymal marker expression induced by FGF-2
HK2 renal tubular cells were starved in serum-free media for 24 hours, then treated for 6 hours with FGF-2 (10 ng/ml) with or without sulodexide (50 μg/ml). Mesenchymal marker expression was subsequently measured by real-time PCR. FGF-2 increased the expression of alpha αSMA, VIM and FN (all markers of EMT). Sulodexide did not affect the basal levels of αSMA, VIM and FN, but it completely prevented their FGF-2-induced overexpression (Figure 3).
Figure 3. Mesenchymal marker expression.A) αSMA, B) VIM and C) FN gene expression in HK2 cells treated with or without FGF-2 and sulodexide. The results represent the mean ± SD of two independent experiments performed in triplicate.
MMP-9 gene expression and activity
Gene expression analysis showed that sulodexide prevents any increase in FGF-2-induced MMP9 gene expression without changing its basal expression level (Figure 4A). Gelatin zymography likewise confirmed that sulodexide abolished the increase in MMP9 induced by FGF-2 (Figure 4B).
Figure 4. MMP9 expression and activity.A) MMP9 gene expression in HK2 cells treated with FGF-2 and sulodexide was measured by real-time PCR. Results represent the mean ± SD of two independent experiments performed in triplicate. B) Above, a representative gelatin zymography displaying MMP9 digestion bands produced by serum-free medium of HK2 cells cultured for 24 hours with FGF-2 and sulodexide. Below, densitometric analysis of MMP9 digestion bands expressed as a percentage of untreated cells. Results represent the mean ± SD of three independent experiments performed in triplicate.
HPSE and SDC1 regulation
Since we recently demonstrated that FGF-2 increases HPSE and reduces SDC1 expression, we looked into whether sulodexide could control these events. We showed that sulodexide does not affect the basal expression of HPSE and SDC1 in HK2 cells, but it does prevent the HPSE overexpression and SDC1 down-regulation induced by FGF-2 (Figure 5A and 5B ).
Figure 5. HPSE and SDC1 gene expression.A) HPSE, and B) SDC1 gene expression evaluated by real-time PCR in HK2 cells treated with or without FGF-2 and sulodexide. Results represent the mean ± SD of two independent experiments performed in triplicate.
Cell motility
During EMT, renal tubular epithelial cells acquire a greater motility, making them better able to migrate through the basal membrane to the interstitium. FGF-2 is one of the factors triggering this event. We showed that sulodexide significantly reduced the migratory capacity of FGF-2 stimulated cells without influencing basal cell migration. We also found that parnaparin and H2046 exhibited the same behavior as sulodexide, whereas DS and D2047 were unable to inhibit HK2 cell migration (Figure 6).
Figure 6. Cell migration. Histograms represent cell migration (in μm) over 24 hours. Data are the means of three separate experiments ± SD.
DN occurs in up to 40% of diabetic patients and is one of the leading causes of ESRD. The approach to treating DN includes the pursuit of normoglycemia and normotension, but the search for new therapeutic strategies to prevent and treat this complication of diabetes is warranted because strict metabolic control can be difficult to achieve in many cases.
The search for new strategies includes seeking molecular targets and, in this perspective, several studies have demonstrated the involvement of HPSE in the pathogenesis of DN [14], at both tubular and glomerular levels [24] HPSE could therefore be a pharmacological target for treating DN. To date, several HPSE inhibitors have been identified, some of which are now being tested in clinical trails. Most of them are modified heparins or LMWHs [25].
GAGs like sulodexide have a favorable effect in DN. A number of mechanisms have been suggested to explain the nephroprotective effect of GAGs and sulodexide [19], including a direct inhibitory effect on HPSE [17], which reportedly increases in the glomeruli of DN patients [24]. The chemical composition of sulodexide gives the product an HPSE inhibiting action [17].
Almost all the above hypothesized mechanisms have been demonstrated at glomerular level, but one of the pathological hallmarks of the progression of kidney disease is tubulo-interstitial fibrosis. The severity of this condition has proved to be much more closely related to the risk of ESRD than glomerular lesions . The accumulation of extracellular matrix in the interstitium is sustained by the transformation of tubular epithelial cells into myofibroblasts (EMT) and this event is triggered by several growth factors and different signaling pathways [5].
We recently showed that HPSE is involved in the regulation of EMT of tubular cells induced by FGF-2. HPSE is necessary for FGF-2 to activate the PI3K/AKT pathway leading to EMT, and for FGF-2 to produce an autocrine loop by down-regulating SDC1 and up-regulating MMP9 and the same HPSE [10].
Here we demonstrate that sulodexide – a combination of GAGs composed of heparin-like (80%) and dermatan fractions (20%) that is currently used to treat thrombotic disorders and DN - is an effective HPSE inhibitor capable of preventing FGF-2-induced EMT in renal tubular cells.
Sulodexide can inhibit HPSE at therapeutic concentrations [26]: its IC50 is 5 μg/ml, and 20 μg/ml of sulodexide suffice to completely inhibit HPSE activity. Investigating the different power of the two ingredients in sulodexide, we found H2046 (and parnaparin) a very effective inhibitor of HPSE, whereas D2047 (and DS) had only a weak inhibitory action. The results of tests on combinations containing different proportions of LMWHs and dermatan sulfates confirmed that sulodexide's HPSE-inhibiting effect is due exclusively to the heparin component, with no synergistic effect between the two ingredients.
These data are consistent with the results obtained by Naggi et al [27] using a different experimental approach. Notably, the Vlodavsky group has shown that sulodexide had a mild inhibitory effect on heparanase enzymatic activity at a concentration of 1 μg/ml, achieving a 50% inhibition with 5 μg/ml, and complete inhibition with 50 μg/ml (personal communication).
As expected, sulodexide - being an HPSE inhibitor - also prevented the overexpression of the mesenchymal markers αSMA, VIM and FN, i.e. it prevented the human renal tubular cell EMT induced by FGF-2.
Sulodexide prevented the increase in HPSE and MMP9 expression and activity and the associated SDC1 reduction that are triggered by FGF-2 in tubular cells, which means that sulodexide switched off the autocrine loop that FGF-2 activates to fuel its signal.
The fact that FGF-2 induced cell migration was inhibited by sulodexide and H2046 (and parnaparin), but not by D2047 (and DS), further confirms that sulodexide prevents FGF-2-induced EMT through its HPSE inhibiting activity.
In conclusion, the present findings - together with the recent demonstration that sulodexide prevented any increase in αSMA and decrease in cytokeratin in the peritoneal membrane of a rat model of peritoneal dialysis [21] - support the conviction that sulodexide could protect against renal fibrosis sustained by EMT, thereby preventing the progression of chronic kidney disease (and DN in particular) to ESRD.
αSMA: alpha smooth muscle actin; DS: dermatan sulfate; DN: diabetic nephropathy; EMT: epithelial-mesenchymal transition; ECM: extracellular matrix; FN: fibronectin; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GAG: glycosaminoglycan; HPSE: Heparanase-1; HS: heparan sulfate; LMWH: low-molecular-weight heparin; MMP9: matrix-metalloprotease 9; SDC1: syndecan-1; VIM: vimentin.
Competing interests
G. Gambaro has received from Alfa Wasserman SpA, Bologna, Italy, grant for research.
Authors' contributions
VM, MO, GZ, AL and GG designed research; VM, MO and GZ conducted research; VM, MO, GZ, AL and GG analyzed data and wrote the paper; GG had primary responsibility for final content. All authors read and approved the final manuscript.
We thank Dr Giuseppe Viscomi (Alfa Wassermann, Bologna, Italy) for kindly providing the sulodexide, its separate ingredients, and Parnaparin.
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Int J Biochem Cell Biol 2006, 38(12):2018-2039. PubMed Abstract | Publisher Full Text
Masola V, Maran C, Tassone E, Zin A, Rosolen A, Onisto M: Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion.
BMC Cancer 2009, 9:304. PubMed Abstract | BioMed Central Full Text | PubMed Central Full Text
Masola V, Gambaro G, Tibaldi E, Onisto M, Abaterusso C, Lupo A: Regulation of heparanase by albumin and advanced glycation end products in proximal tubular cells.
Biochim Biophys Acta 2011, 1813(8):1475-1482. PubMed Abstract | Publisher Full Text
Gil N, Goldberg R, Neuman T, Garsen M, Zcharia E, Rubinstein AM, van Kuppevelt T, Meirovitz A, Pisano C, Li JP, van der Vlag J, Vlodavsky I, Elkin M: Heparanase is essential for the development of diabetic nephropathy in mice.
Diabetes 2012, 61(1):208-216. PubMed Abstract | Publisher Full Text | PubMed Central Full Text
Rops AL, van den Hoven MJ, Veldman BA, Salemink S, Vervoort G, Elving LD, Aten J, Wetzels JF, van der Vlag J, Berden JH: Urinary heparanase activity in patients with Type 1 and Type 2 diabetes.
Nephrol Dial Transplant 2012, 27(7):2853-2861. PubMed Abstract | Publisher Full Text
Chen S, Fang Z, Zhu Z, Deng A, Liu J, Zhang C: Protective effect of sulodexide on podocyte injury in adriamycin nephropathy rats.
J Huazhong Univ Sci Technol Med Sci 2009, 29(6):715-719. PubMed Abstract | Publisher Full Text
Lewis EJ, Xu X: Abnormal glomerular permeability characteristics in diabetic nephropathy: implications for the therapeutic use of low-molecular weight heparin.
Diabetes Care 2008, 31(Suppl 2):S202-S207. PubMed Abstract | Publisher Full Text
Wijnhoven TJ, Lensen JF, Rops AL, McCarthy KJ, van der Vlag J, Berden JH, van den Heuvel LP, van Kuppevelt TH: Anti-proteinuric effects of glycosaminoglycan-based drugs.
Curr Opin Mol Ther 2007, 9(4):364-377. PubMed Abstract
Weiss R, Niecestro R, Raz I: The role of sulodexide in the treatment of diabetic nephropathy.
Drugs 2007, 67(18):2681-2696. PubMed Abstract | Publisher Full Text
Abaterusso C, Gambaro G: The role of glycosaminoglycans and sulodexide in the treatment of diabetic nephropathy.
Treat Endocrinol 2006, 5(4):211-222. PubMed Abstract | Publisher Full Text
Pletinck A, Van Landschoot M, Steppan S, Laukens D, Passlick-Deetjen J, Vanholder R, Van Biesen W: Oral supplementation with sulodexide inhibits neo-angiogenesis in a rat model of peritoneal perfusion.
Nephrol Dial Transplant 2012, 27(2):548-556. PubMed Abstract | Publisher Full Text
Onisto M, Slongo ML, Gregnanin L, Gastaldi T, Carli M, Rosolen A: Expression and activity of vascular endothelial growth factor and metalloproteinases in alveolar and embryonal rhabdomyosarcoma cell lines.
Int J Oncol 2005, 27(3):791-798. PubMed Abstract | Publisher Full Text
Liang CC, Park AY, Guan JL: In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro.
Nat Protoc 2007, 2(2):329-333. PubMed Abstract | Publisher Full Text
van den Hoven MJ, Rops AL, Bakker MA, Aten J, Rutjes N, Roestenberg P, Goldschmeding R, Zcharia E, Vlodavsky I, van der Vlag J, Berden JH: Increased expression of heparanase in overt diabetic nephropathy.
Kidney Int 2006, 70(12):2100-2108. PubMed Abstract | Publisher Full Text
Nasser NJ: Heparanase involvement in physiology and disease.
Cell Mol Life Sci 2008, 65(11):1706-1715. PubMed Abstract | Publisher Full Text
Lauver DA, Lucchesi BR: Sulodexide: a renewed interest in this glycosaminoglycan.
Cardiovasc Drug Rev 2006, 24(3–4):214-226. PubMed Abstract | Publisher Full Text
Naggi A, Casu B, Perez M, Torri G, Cassinelli G, Penco S, Pisano C, Giannini G, Ishai-Michaeli R, Vlodavsky I: Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting.
J Biol Chem 2005, 280(13):12103-12113. PubMed Abstract | Publisher Full Text


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The Stinger Wild Honey Wheat Ale from Estes Park Brewery in Estes Park, Colorado pours out a cloudy, golden copper in color and is topped with a half finger of fizzy, white head that reduces quite quickly. On the nose, aromas of honey, spice and some floral. In the mouth, slightly sweet from the 6 pounds of honey added per barrel, a little grainy and some decent coriander like spice. Light bodied. Low carbonation. Little lacing on the glass. Clean mouthfeel. Honey outlasts all other flavor on a good length, slightly dry finish.
A good wheat ale. My bottle seemed to have little carbonation so it might be a little old (no bottled on date) but other than that the flavor was very good. Recommended.
12 ounce bottle, 6.0% ABV
Beer 180 of 366 for 2012


text:
Jeff Mangum, the Louisiana-based musician best known as the Neutral Milk Hotel frontman among other music projects, is adding new tour dates to his North American tour this fall. A limited number of tickets to the sold-out Boston, MA show in September have also been released as well. The Boston tickets will be available on June 21 at noon, while tickets for the new shows will be available at noon the day after.
Fans of the now-disbanded Neutral Milk Hotel will have a chance to see their favorite songs performed live by Mangum, and his fall tour has been much anticipated as many of the stops have already sold out. The success of Neutral Milk Hotel's In The Airplane Over The Sea and the band's new-found fame added pressure to Mangum, and it disbanded in 1998 after touring with the album. After staying out of the public eye and playing rare acoustic sets, Mangum is ready to hit the road again this fall, and those who buy tickets to the newly added show dates will donate $1 to benefit the charity Children Of The Blue Sky.
Tour Dates For Jeff Mangum (New Shows In Bold):
08/08 – Burlington, VT – First Unitarian Church
08/10 – Montreal, QC – Cabaret Du Mile-End
08/12 – Toronto, ON – Trinity St. Paul's United Church
08/13 – Toronto, ON – Trinity St. Paul's United Church
09/07 – Northampton, MA – Academy Of Music Theatre
09/09 – Cambridge, MA – Sanders Theatre At Harvard University
09/10 – Boston, MA – Jordan Hall at New England Conservatory
09/26 – Baltimore, MD – 2640 Space At St. John's Church
09/27 – Baltimore, MD – 2640 Space At St. John's Church*
09/30 – Asbury Park, NJ – ATP America – Paramount Theatre
10/03 – Asbury Park, NJ – Paramount Theatre*
10/29 – New York, NY – Town Hall
10/06 – Jersey City, NJ – Loew's Jersey Theatre
11/30 – Dublin, IRE – Whelan's
12/02 – 12/04 – Minehead, UK – All Tomorrow's Parties
12/08 – London, UK – Union Chapel
12/09 – London, UK – Union Chapel
*with A Hawk And A Hacksaw


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Book your room at Villa Il Poggiale Dimora Storica
Get an overview of this hotelFamily-friendly residence with full-service spa and free breakfast
Collect 200 points
Simply enter your Nectar card number when prompted. Your points will be credited 30 days after you return from your trip.*Offers may apply
Located in the historical district, this family-friendly residence is within 9 mi (15 km) of World War II Florence American Cemetery and Memorial, Certosa Museum, and Florence Charterhouse. Piazza Niccolo Acciaioli and Piazza Machiavelli are also within 9 mi (15 km).
Property Features
A full-service spa, a restaurant, and an outdoor pool are available at this residence. Free buffet breakfast is provided, as well as free WiFi in public areas, free self parking, and a free manager's reception. Additionally, a bar/lounge, a coffee shop/café, and a spa tub are onsite.
Room Amenities
All 24 rooms provide conveniences like sofa beds and coffee makers, plus free WiFi and satellite TV. Other amenities available to guests include minibars (stocked with some free items), free bottled water, and hair dryers.Information missing or incorrect? Tell us!
Hotel Amenities
Hotel Amenities
In addition to a full-service spa, Villa Il Poggiale Dimora Storica features an outdoor pool and a spa tub. Dining options at the residence include a restaurant and a coffee shop/café. A bar/lounge is on site where guests can unwind with a drink. Guests are offered a complimentary breakfast each morning and a complimentary manager's reception is offered on select days. Public areas are equipped with complimentary high-speed wireless Internet access.
Business-related amenities consist of a meeting room and meeting rooms. This family-friendly residence also offers a sauna, spa services, and a library. Complimentary self parking is available on site.
- Free WiFi
- Total number of rooms - 24
- Bar/lounge
- Coffee/tea in lobby
- Coffee shop or café
- Free breakfast
- Front desk (limited hours)
- Full-service spa
- Tours/ticket assistance
- Library
- Spa treatment room(s)
- Meeting rooms
- One meeting room
- Multilingual staff
- Garden
- Restaurant
- Safe-deposit box at front desk
- Free self parking
- Year Built 1418
- Free reception
- Sauna
- Spa services on site
- Spa tub
- Outdoor pool
Family Friendly Amenities
- Family Hotel
- Outdoor pool
- Free Wi-Fi
- Rollaway/extra beds available
- Sofa bed
- Cribs/infant beds (complimentary)
Available in all rooms: Free WiFi
Available in some public areas: Free WiFi
Free self parking
Room Amenities
- Climate control
- Air conditioning
- Minibar (stocked, some free items)
- Free bottled water
- Coffee/tea maker
- Hair dryer
- Bathtub or shower
- Desk
- In-room safe
- Sofa bed
- Rollaway/extra beds available
- Satellite TV service
- Free WiFi
- Free cribs/infant beds
Where to Eat
A complimentary buffet breakfast is served each morning between 8 AM and 10:00 AM. The residence offers a complimentary manager's reception on select days.
Villa Il Poggiale Dimora Storica has a restaurant on site.
Nearby Things to Do
An outdoor pool and a spa tub are on site. Other recreational amenities include a sauna.
The recreational activities listed below are available either on site or nearby; fees may apply.
- Free bicycles on site
Spa Services
The onsite spa has 2 treatment rooms including rooms for couples. Services include hot stone massages, Thai massages, massages, and body scrubs. A variety of treatment therapies are provided, including Ayurvedic and reflexology. The spa is equipped with a sauna and a spa tub.
The spa is open daily. Children under 12 years old are not allowed in the spa without adult supervision. Guests under 8 years old are not allowed in the spa.
- Hot stone massage
- Thai massage
- Reflexology
- Spa tub in spa
- Massages
- Minimum age to access spa is 8
- Number of treatment rooms 2
- Couples treatment rooms
- Body scrubs
- Ayurvedic treatments
- Sauna in spa
- Body treatments
Hotel Policies
Check-in time starts at 1:00 PM
Check-in time ends at 7 PM
Special check-in instructions:
Check-out time is 11 AM
Payment types
Pets allowed, Maximum number of pets per room 1
You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- A tax is imposed by the city: EUR 2.5 per person, per night, up to 4 nights. This tax does not apply to children under 14 years of age.
- Airport shuttle fee: EUR 30.00 per person (one way)
- Rollaway beds are available for an additional fee
We should mention
Cash transactions at this property cannot exceed EUR 999.99, due to national regulations. For further details, please contact the property using information in the booking confirmation. One child 2 years old or younger stays free when occupying the parent or guardian's room, using existing bedding.


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Roxanne is riveting. Miniature studs race around the trim. Hidden studs are cleverly concealed beneath the strap and tabs. Forged harness rings join the strap to body and serve as a handy closure. Cell and zip pockets inside.
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Department of History
Department of History
The Warwick University History Department is one of the largest history departments in the UK. Forty full-time academic staff engage in research notable for its disciplinary range and geographical scope (Africa, the Americas, Asia, the Caribbean, and Europe). We currently have a student population of approximately 1,000 undergraduates and 100 postgraduates.
The Department has a strong international reputation and high rankings in university guides and surveys, and was ranked first in the UK in the 2014 Research Excellence Framework (REF) for the proportion of world-leading research activity (4*) in the Department.
The Department has been awarded £5.1m in research grants and contracts in the past five years, for a wide variety of projects, networks, conferences, and fellowships.The Department is home to the School of Comparative American Studies, the Centre for the History of Medicine, the Early Modern Forum, the Eighteenth Century Centre, the European History Research Centre, and the Global History and Culture Centre. The Department also has close connections with the Centre for the Study of the Renaissance and the Yesu Persaud Centre for Caribbean Studies.


text:
Summer Research Opportunities Database
You could spend six to 10 weeks during your summer doing research with world-class faculty at leading institutions, while earning between $2,000 and $5,000 or more. Many colleges and universities, medical schools, federal agencies and corporations offer hundreds of paid summer research opportunities for students in all fields of study.
Besides learning new skills and concepts you will have an opportunity to apply previous knowledge learned in your classes and labs to a real research project. In addition, you get great exposure to the current technology, trends and literature in the scientific community, not to mention meeting researchers and learning the issues in your field of study. You will also create a network of professionals in your field including faculty who can write reference letters for your applications for graduate or professional school, graduates students and post-docs who can help you learn your way around cutting-edge technology and fellow undergraduate students, who can become part of a network of peers who can give you support after you graduate.
Most of these programs are in the sciences. However, many institutions also offer summer research projects in disciplines such as humanities, business and social sciences. Many of the summer research projects are designed to attract students from groups considered under-represented in their relevant disciplines and are designed to help the institutions increase diversity in their programs. There are also some programs for pre-meds students, but most are for students interested in research graduate programs.
Generally most research projects require an application with a statement of purpose (a description of your development as a scholar in your field thus far and why summer research would help your professional development), a resume and letters of recommendation. Deadlines vary but they generally start in January and continue through the spring. The most competitive programs tend to be earlier.
The search engine below is an excellent source of information about available summer research opportunities and where to apply. The database has information about summer programs that can be searched by various criteria. It is better to start with a broad search and narrow from there. Information has been updated for programs for whom new information is available, but some of these programs may have ended, have new deadlines, etc, so students should check on the program websites or with the contact people to insure that the program is continuing. This list is not exhaustive, so check multiple websites. You can also Google "undergraduate summer research" and refine it by school or by discipline.
Go for it!


text:
Not Peer Reviewed
King Lear (Folio 1, 1623)
Actus Quintus. Scena Prima.
Enter with Drumme and Colours,_Edmund,_Regan.
2847Bast. Know of the Duke if his last purpose hold,
2848Or whether since he is aduis'd by ought
2849To change the course,_he's full of alteration,
2850And selfe_reprouing,_bring his constant pleasure.
2851Reg. Our Sisters man is certainely miscarried.
2852Bast. 'Tis to be doubted Madam.
2853Reg. Now sweet Lord,
2854You know the goodnesse I intend vpon you:
2855Tell me but truly,_but then speake the truth,
2856Do you not loue my Sister?
2857Bast. In honour'd Loue.
2858Reg. But haue you neuer found my Brothers way,
2859To the fore-fended place?
2860Bast. No by mine honour,_Madam.
2861Reg. I neuer shall endure her,_deere my Lord
2862Be not familiar with her.
2863Bast. Feare not,_she and the Duke her husband.
Enter with Drum and Colours,_Albany, Gonerill,_Soldiers.
2865Alb. Our very louing Sister, well be-met:
2866Sir,_this I heard,_the King is come to his Daughter
2867With others,_whom the rigour of our State
2868Forc'd to cry out.
2869Regan. Why is this reasond?
2870Gone. Combine together 'gainst the Enemie:
2871For these domesticke and particurlar broiles,
2872Are not the question heere.
2873Alb. Let's then determine with th'ancient of warre
2874On our proceeding.
2875Reg. Sister you'le go with vs?
2876Gon. No.
2877Reg. 'Tis most conuenient,_pray go with vs.
2878Gon. Oh ho,_I know the Riddle, I will goe.
Exeunt both the Armies.
Enter Edgar.
2881Edg. If ere your Grace had speech with man so poore,
2882Heare me one word.
2883Alb. Ile ouertake you,_speake.
2884Edg. Before you fight the Battaile,_ope this Letter:
2885If you haue victory,_let the Trumpet sound
2886For him that brought it: wretched though I_seeme,
2887I can produce a Champion,_that will proue
2888What is auouched there. If you miscarry,
2889Your businesse of the world hath so an end,
2890And machination ceases. Fortune loues you.
2891Alb. Stay till I haue read the Letter.
2892Edg. I was forbid it:
2893When time shall serue,_let but the Herald cry,
2894And Ile appeare againe.
2895Alb. Why farethee well,_I will o're-looke thy paper.
Enter Edmund.
2897Bast. The Enemy's in view,_draw vp your powers,
2898Heere is the guesse of their true strength and Forces,
2899By dilligent discouerie,_but your hast
2900Is now vrg'd on you.
2901Alb. We will greet the time.
2902Bast. To both these Sisters haue I sworne my loue:
2903Each iealous of the other,_as the stung
2904Are of the Adder. Which of them shall I take?
2905Both? One_? Or neither?_Neither can be enioy'd
2906If both remaine aliue: To take the Widdow,
2907Exasperates,_makes mad her Sister Gonerill,
2908And hardly shall I carry out my side,
2909Her husband being aliue. Now then,_wee'l vse
2910His countenance for the Battaile,_which being done,
2911Let her who would be rid of him,_deuise
2912His speedy taking off. As for the mercie
2913Which he intends to Lear and to Cordelia,
2914The Battaile done,_and they within our power,
2915Shall neuer see his pardon: for my state,
2916Stands on me to defend,_not to debate.


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I love to watch The Real Housewives of… Well, any city, state or county. New York City, New Jersey, Orange County, Beverly Hills, Atlanta. I'm there. And, I love the spin-off, Bethenny Ever After. (I even emailed Bethenny to invite her to be a guest on the talk show to discuss forgiveness.)
The reality of their lives fascinates. They live in beautiful homes, they eat out a lot (and don't gain weight), they attend parties on school nights, they bicker constantly with each other and then meet the next day for shopping and lunch.
It's like walking through the neighborhood at night so you can get a peak inside the neighbors' houses. Oh, what you can see when the lights are on.
Sometimes, though, the reality ends up being a fantasy. We learn that some of these real housewives spend too much and land in bankruptcy. It seems these stars have a public face they wish to show, at any cost.
I spent time this weekend with friends I don't see often. The friends spoke for quite a long time about their cars, why they drive what they drive, what they'll buy next, what cars they admire.
As the talk of cars spun around me, I almost moved my chair. Their reality—a reality of the newest, the fanciest—seemed so foreign. They seemed to speaking a language I didn't understand.
I remember thinking: But… I thought everyone talked about how to make the most of the lives, of how to manage stressful situations with grace, of how to provide quality of life when quality seems scarce.
Then I realized: That's what you do. And, you're not everyone. Caregiving certainly sucks. It drains you—emotionally, financially, physically. But, it makes you such a wonderful dinner companion. You have insights and perspectives on life that make your company so much better than the company of those who only know about the latest car models.
I'll always enjoy watching reality TV. It's a terrific distraction.
But I'll always find your reality so much more compelling and worthwhile. Your light is always on. I can see who you are because you live who you are.
From you, I learn that life, well lived with a real heart and soul, brings in the best ratings.
- Our Caregiving Summer School, Session II, starts next week! Our classes will help you understand where you've been so you can plan for where you're going on your caregiving journey. Our classes also help you start your journal; set boundaries; accept help; and start Mondays on the right foot. Each class costs $27 and takes place conveniently over the phone. Register today here.
Related Articles
- Tangled (caregiving.com)
- Next Time (caregiving.com)
- A Wrong Turn Into the Right Life (caregiving.com)
- Jail (caregiving.com)


text:
DENTON The Texas Woman's University Board of Regents
elected Linda Loveless Hughes, M.D., chair and presiding officer
and Delia Reyes vice-chair and assistant presiding officer during
the board's Feb. 28 meeting.
Dr. Hughes, of Dallas, was appointed to the board in 1999 and
served as vice-chair and assistant presiding officer from 2001
until her election as chair. She is a graduate of Denton High
School, the University of Texas at Austin and the University of
Texas Southwestern Medical School in Dallas. She recently was
elected the first woman president of the University of Texas
Southwestern Medical School Alumni Association.
Dr. Hughes practiced psychiatry in Dallas and Plano for 27
years. She is a Fellow of the American Psychiatric Association
and a board examiner for the American Board of Psychiatry and
Ms. Reyes, also appointed to the board in 1999, is president
and CEO of Reyes Consulting Corp. of Dallas which
specializes in corporate strategic planning, community
development, special segment marketing and recruitment of
minorities and women to senior/executive-level positions. She
also is CEO of Adrian Information Strategies, a full-service
market research and information processing firm in Addison.
The first and only woman to chair the United States Hispanic
Chamber of Commerce, Ms. Reyes makes public speaking appearances
to discuss workforce diversity, women and minority business
issues and Hispanic marketing. She was appointed in 1992 by
President George H.W. Bush to the Federal Glass Ceiling
Commission. She was named Hispanic Woman of the Year by the
Mexican American Opportunity Foundation of Los Angeles (1995),
Texas Businesswoman of the Year by the Texas Association of
Minority Business Enterprises (1992) and Female Entrepreneur of
the Year by the Dallas Hispanic Chamber of Commerce (1991).


text:
Golf: "Calling me a cheat is disgusting"-A A +A
Friday, February 7, 2014
PGA Tour Updates. The Waste Management Phoenix Open was held last January 30 – February 2, 2014 at TPC Scottsdale, Arizona. Whenever I think of Arizona, I think of warm weather. Speaking of Arizona, it has been so hot here in Davao lately. What happened to the cool weather a week ago? According to the news, this hot weather is only temporary.
Some of you pa naman were looking forward to wearing your newly bought sweaters from the night market ukay ukay at Roxas. Hehe.
Here are the winners of the Phoenix Open. Kevin Stadler, champion. Tied for 2nd place – Graham DeLaet and Bubba Watson. Tied for 4th place – Hunter Mahan and Hideki Matsuyama. Tied for 6th place – Charles Howell III, Ryan Moore and Brendan Steele. In 9th place, Harris English. In 10th place – Webb Simpson.
Other notables. Phil Mickelson and KJ Choi, tied for 42nd place.
Brandt Snedeker, tied for 61st place. Some of the players who were cut – Padraig Harrington, Lee Westwood, Retief Goosen, Rickie Fowler, Justin Leonard, Ian Poulter, David Toms, Ryo Ishikawa, and more. I guess many of these good players are still searching for their game.
Where was Tiger? Tiger Woods and Rory McIlroy were in Dubai for the Omega Dubai Desert Classic held at the Emirates Golf Club. Defending champion Stephen Gallacher emerged as champion once again. Tiger Woods finished tied for 41st place. Rory McIlroy finished tied for 9th place. Golf break. I watched Mayor Duterte on tv at the Senate hearing. I won't go into details anymore. One word. Amusing! And so, besides this and besides the Deniece Cornejo-Cedric Lee-Vhong Navarro issue, what is everyone talking about?
Speaking of Vhong Navarro, did you know that he has a current 5-year girlfriend? I read that on the internet. Whether it is a case of extortion or rape or both, a writer from Rappler.com said, "it takes two to tango." There was cheating. They both cheated. I agree. Cedric Lee showed his rage to us. But how about Vhong's non showbiz girlfriend? I feel sorry for her, the forgotten victim, the one most hurt.
Guys, if you have not watched the 1987 thriller called Fatal Attraction with Michael Douglas and Glenn Close, download and watch it. The lesson there is...ahem. If we relate this to golf, remember, our golfing friend from Davao who was charged with rape several years ago and was sent to jail for some time…Let that be a reminder too.
Speaking of cheating and recent scandals in golf, Sergio Garcia was a victim of it. He was accused of cheating during the Abu Dhabi HSBC Championship last January. He supposedly tapped down a spike mark on his line of putt which is illegal. But, apparently, it was a pitch mark that he tapped down and this is allowed in the Rules of Golf.
I would be furious if I were to be called a cheater. And my game would definitely get affected. I can just imagine how angry Sergio Garcia was after being accused. Sergio Garcia told the media, "Calling me a cheat is disgusting!"
Congratulations to the winners of the 2014 PAWD Fellowship Golf Tournament held at Apo Golf & Country Club last February 4, 2014. Here they are: overall gross champion – Fred Albarillo; class A champion – Boy Braganza, 1st runner-up – Jeffrey Ong, 2nd runner-up – Warly Manlapas; Class B champion – Rey Anonuevo, 1st runner-up – Ega Cordero, 2nd runner-up – Charlie Aldevera; class C champion – Rene Ronquillo, 1st runner-up – Rey Atienza, 2nd runner-up – Chito Vasquez; ladies division champion – Rowena Capili, 1st runner-up – Reahna Abella; nearest the pin hole 11 – Rene Ronquillo; most accurate drive hole 1 – Brando Atienza; longest drive (310 yards) – Jeffrey Ong; most birdies – Fred Albarillo; most doubles – Jaime Lopez, most exercised (124) – Ike Pastor.
Published in the Sun.Star Davao newspaper on February 07, 2014.
Country News
Cagayan de Oro
Forum rules: Do not use obscenity. Some words have been banned. Stick to the topic. Do not veer away from the discussion. Be coherent and respectful. Do not shout or use CAPITAL LETTERS!


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Jobs Board
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Western Sky
Western Sky
As we stood staring at it through the iron grille set in the archway of the lodge, Nick declared that it put him in mind of some of the chateaux he had seen in France, and he crossed the street to get a better view of the premises. Western Sky and Perhaps here lay the secret of the hardness he had accused himself of: he had too little fellow-feeling with the weakness that errs in spite of foreseen consequences. We just shot 'em—the squirrels. The east part of the building appeared to be the living-room, about twenty by twenty-five feet. There's plenty of pretty girls to give us a good time," Blondie said. Then he sighed, and said, "You explain very well, Monsieur Gamm, but if only I had your opportunities to listen for myself! His black eyes showed a ring of white about them as he stared at the empty ground. But my son Hephaestus whom I bare was weakly among all the blessed gods and shrivelled of foot, a shame and disgrace to me in heaven, whom I myself took in my hands and cast out so that he fell in the great sea.
western sky loans
and The guns on our left fired for a long time on Buller's camp, the ones on our right on us. The pompiers were clothed in asbestos, over which was a network of iron. A great four-poster bedstead was in one corner, and a polished mahogany dresser in the other. Once, when I could not reach the yard, and now, the second time, when these fishers turned a deaf ear to my cries. Osborne and Mr. Western Sky and I AM rather free about women, he had often said, smiling and nodding knowingly to Stubble and Spooney, and other comrades of the mess-table; and they rather respected him than otherwise for this prowess. He won't hurt you," meanwhile patting her shoulder reassuringly. The hypocrites shall not deceive us into thinking them saints; but neither shall they deceive us into thinking them hypocrites. Auguste's voice aroused me. So the anxious heart-stricken Adam must of necessity wait and try to rest till morning—nay, till eleven o'clock, when the coach started. My father is high chief among the Galus. Western Sky and The greatest danger to which society is exposed to-day is that of another shipwreck on this rock. We watched them in silence as they drew nearer, and then something in the walk and appearance of the foremost began to bother me. The chief landmarks in the poem are as follows: after the first 103 lines, which contain at least three distinct preludes, three primeval beings are introduced, Chaos, Earth, and Eros—here an indefinite reproductive influence. I told her I had made a positive bargain or agreement with him to go, if he could get the liberty of going in the same ship, and that I found he had money. There is something so singular in the way in which I was led to attack property, that if, on hearing my sad story, you persist, sir, in your blame, I hope at least you will be forced to pity me. But this aggravated him more than before, that she should put so far upon him, and run things such a length upon no other authority than a hearsay; and then, turning to me again, said very honestly, he was afraid we were both undone. Western Sky and The girl ran her fingers into that mass of hair and looked puzzled. My!' said he. Temple might not stay. Amelia too laughed. It recalled her to the world and the remembrance of yesterday. It was all well enough for Jane to say he was handsome. Now, I am for generalization, induction, and progress. I saw him level and fire, and then Bill Cowan set me down and began to ram in a charge with tremendous energy. If he had failed to make a physician, it was not because his heart was so tender that he could not bear to look upon pain and suffering. And again David noticed that odd shifting of Miss Holbrook's gaze as if she were searching for some means of escape. We both grabbed it and pulled, bringing to life a person with little blue eyes and stiff blond hair. The sum he had to give her was so large that he was obliged to ask for time; so large as to be a little fortune to Rebecca, who rapidly calculated that with this sum, and the sale of the residue of Rawdon's effects, and her pension as a widow should he fall, she would now be absolutely independent of the world, and might look her weeds steadily in the face. It is true the design of deluding a woman of fortune, if I had been so, was base enough; the putting the face of great things upon poor circumstances was a fraud, and bad enough; but the case a little differed too, and that in his favour, for he was not a rake that made a trade to delude women, and, as some have done, get six or seven fortunes after one another, and then rifle and run away from them; but he was really a gentleman, unfortunate and low, but had lived well; and though, if I had had a fortune, I should have been enraged at the slut for betraying me, yet really for the man, a fortune would not have been ill bestowed on him, for he was a lovely person indeed, of generous principles, good sense, and of abundance of good-humour. Jack walking, and so self-absorbed was he, that he did not see the carriage until it was almost upon him; then he stepped aside to let it pass. If she can, it will make an excellent starting-point for our investigation.