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Posted by Derek
Just as an addendum to this morning's post, a quick question: can anyone name an antibiotic that was brought up through a target-driven approach? That is, not one that's a variation on an existing class, or has its origins in a hey-that-killed-bugs assay. I mean, one that started off with people saying "OK, XYZase looks to be essential in bacteria, and higher organisms don't have it. Nothing's on the market that works that way, but it looks to be a good target, so let's go after it".
Off the top of my head, I can't think of one. There may be an example somewhere, but just the fact that I'm having to rack my brain about it says something. Doesn't it?
Comments (31)
+ TrackBacks (0) | Category: Infectious Diseases
1. CMC Guy on March 11, 2009 11:17 AM writes...
Do quinolones meet your criteria? I don't really know their genesis as antibiotics so may be "hey-that-killed-bugs" starting point but know much work in the 80s focused on this class that (if I recall MOA) does target a specific enzyme in bacteria that not in humans.
2. Derek Lowe on March 11, 2009 11:24 AM writes...
Nope, those go back to an accident, too. Nalidixic acid, the prototype compound of the whole class, was a side product from chloroquine work back in the late 1950s: http://www.baytril.com/6/History.htm
3. Jose on March 11, 2009 11:41 AM writes...
Recent C&EN story on FTSZ targeted compounds might fit the bill.
4. Ben on March 11, 2009 11:53 AM writes...
How about the beta lactamase inhibitors?
5. SciChick on March 11, 2009 12:01 PM writes...
How about isoniazide for M. tuberculosis?
6. Tim on March 11, 2009 12:06 PM writes...
Avexa has an antibacterial which is currently preclinical but should move into clinical trials in the next 18 months.
Drugs with research codes AVX-13613, AVX-13616, AVX-13617, AVX-13619 and AVX-13781 are all peptides which are designed to bind to both D-Ala-D-Ala and D-Ala-D-Lac growing cell wall terminus.
More info at Thomson Pharma drug id=52682.
Not at market stage yet, but the best example that I can think of.
7. Ty on March 11, 2009 12:13 PM writes...
I didn't see the C&EN, but a quick survey suggests that FtsZ inhibitors are still in the preclinical stage at best. So are a lot of other "targeted" antibiotics. Guess Derek's question is whether there's any real drug discovered and developed in that way. I cannot think of any, other than those whose target was identified after the fact. I am not in the field, so I cannot be sure.
Another somewhat naive question related to antibiotics is, I've been wondering why so many, if not all, antibiotics have a putative metal chelating motif. Is this just a biased observation or is there any plausible explanation?
8. Orgmed on March 11, 2009 12:15 PM writes...
Hi Derek,
If not to the market but lots of current work is a target-driven;
1.Targent Therapeutics --Identified a new class of selective RNA polymerase (RNAP) compounds
that exhibit antibacterial properties against S. aureus.
2.Peptide deformylase -- Several companies. 3.MurA/B
5.As Jose mentioned -- FtsZ -- Wyeth and others
6.Non-b-lactam inhibitors of b-lactamase
7.Linezolide: I am not sure if it is target driven but it targets Ribosome.
9. Orgmed on March 11, 2009 12:23 PM writes...
My question is if we design target specific MRSA agents, how one can address the plasma protein binding issue. They exhibit very potent activities without serum. When we test them in serum they show no activity. Potent antibacterial agents always have protein binding issues. Any thoughts.
10. Mad on March 11, 2009 12:26 PM writes...
Not technically an antibiotic but protease inhibitors for HIV fit the design concept.
11. Derek Lowe on March 11, 2009 12:28 PM writes...
Oh, I know that there's plenty of target-driven stuff going on, and has been for many years. It's just that it's been very hard for any of it to make it all the way to a drug.
As for the specific examples people have brought up: beta-lactamase inhibitors aren't really antibiotics on their own (and the most widely used one, clavulanic acid, is a natural product). FtsZ hasn't made it out of the clinic yet (but good luck to it!) And isoniazid was discovered after nicotinamide was found to have antibacterial effects in the 1940s; the mechanism wasn't clear for many years afterwards.
12. Tim on March 11, 2009 12:33 PM writes...
What about multi action antibiotics? This paper by Bremner et al ACS Chem Biol, Vol. 1, No. 9. (24 October 2006), pp. 594-600.
describes amplification of berbarine activity by addition of a an efflux inhibitor. More intelligent design that is target orientated.
13. Yancey Ward on March 11, 2009 12:43 PM writes...
There are a lot of target driven research going on at present, but I can't think of a single marketed drug that arose from such research, but I think the reason is pretty obvious- it was always pretty easy to use the "it kills bugs" approach to anti-bacterial discovery, and, until the last 15 years or so, the historic anti-bacterials were so efficacious that there wasn't much room for new ones.
14. Lucifer on March 11, 2009 2:12 PM writes...
So tell me again.. how were sulfa drugs discovered? By injecting "inactive" dyes in infected rats.
How were organoarsenicals discovered? By following a hunch?
How were the the actinomycete antibiotics discovered? Trial+ error and a system that was willing to spend money on research with poor returns! Most were too toxic for human use- you are just seeing the survivors.
How were the first synthetic anti-malarials discovered? By trying to make crude simplified versions of quinine + a few hunches.
It is not hard, the problem is that MBAs and modern 'drug discoverers' think they can make nature behave and answer questions at their leisure. Hubris!
15. milkshake on March 11, 2009 2:52 PM writes...
MBAs = Mediocre But Arrogant, and Me Before Anyone. Now, I can think of a perfect shovel-ready project...
16. CMC Guy on March 11, 2009 2:58 PM writes...
Derek thank you for lesson on quinolone history. I never worked in antibiotics directly (unless making SMs counts) although knew many (lost?) souls that labored in that area. They complained almost as loudly as people doing carbohydrates. As you have done both you must be extra thick skinned to survive.
17. Lucifer on March 11, 2009 3:01 PM writes...
But guillotines are not shovel ready. It takes some planning to build the infrastructure, collect an angry crowd and organize the event.
"MBAs = Mediocre But Arrogant, and Me Before Anyone. Now, I can think of a perfect shovel-ready project..."
18. Lynn on March 11, 2009 4:24 PM writes...
Some of the later classes of marketed cell wall antibiotics (monobactams, carbapenems, cephamycin, fosfomycin [all beta-lactams but the last]) were found by screening (natural products)for cell-wall inhibitory phenotypes. Trimethoprim was found by screening pyrimidine derivatives for folate antagonism (antimetabolite activity). But that's it. The parent compounds for all other marketed classes of antibacterials were found by empirical screening. As Derek says, there have been a tremendous number of specific enzyme targeted, using both biochemical and whole cell screens, with many leads generated. Some have reached the clinic - none have made it past Phase I. For various reasons including resistance selection, poor pharmacokinetics, tox, serum binding... The Avexa compounds sound interesting; they are peptides rationally modeled on the mechanism of vancomycin, but designed to hit the van resistant D-ala-D-lac as well as D-ala-D-ala. This is not an enzyme target but a structural target (and unlikely to be subject to rapid resistance selection). Let's see how they do.
19. Thomas McEntee on March 11, 2009 6:20 PM writes...
So we're spending lots of tax dollars to build telescopes and fund surveys intended to find nasty near-Earth-orbit asteroids that might come close...what are we spending on screening what's here on Earth for new antibiotics? The consequences of an asteroid impact or a steady or increasing rate of evolution of other multi-drug resistant bacteria might be quite similar. As a child I read about Waksman (but it really was Schatz) and the discovery of streptomycin & neomycin. I know, screening's a low-payoff venture but it sounds like the current approaches aren't high ROI ventures either. Can anyone conceive of something, say, microfluidics-like devices, that could be manufactured by the zillions and used to screen the natural products of the planet, including all the dirt, mud, and ooze? Nature's variety is enormous...we have no idea of the numbers of bacterial species. As someone pointed out, these bacteria do battle with one another, pump out defensins and other chemicals. Has anyone thought of high-tech--I'll say Silicon Valley--ways of exploiting what is probably sitting right under our noses?
20. Bryan Czyzewski on March 11, 2009 6:48 PM writes...
I wanted to point out two things that I hadn't appreciated until recently concerning bactericidal mechanisms: 1) for every natural product used by bacteria in chemical warfare (read: almost all antibiotics ever discovered) there is a resistance mechanism, otherwise the bacteria that produced the substance would not survive; 2) It is better to be bacteriostatic then bactericidal. The former puts less pressure to come up with ways of overcoming the antibiotic.
21. Bryan Czyzewski on March 11, 2009 6:52 PM writes...
"OK, XYZase looks to be essential in bacteria, and higher organisms don't have it. Nothing's on the market that works that way, but it looks to be a good target, so let's go after it".
Menaquinone inhibitors are a new antibiotic target class that inhibit the alternative vitamin K synthesis pathway that gram negative and some positive use for electron transport.
22. DR on March 11, 2009 9:46 PM writes...
@17: "But guillotines are not shovel ready."
milkshake may have been inspired by that famous Russian word that covers multiple uses for a shovel.
23. Lynn on March 11, 2009 11:04 PM writes...
to #19 - it's easy - and relatively cheap - to screen natural product fermentations and extracts for antibacterial activity at quite high throughput - microfluidically, etc. The problem is that the broths and extracts are complex mixtures and identifying novel hits [based on structure] from among the very high number of already-described antibiotics is difficult. So you need "dereplication" systems, which can be via chemical means or biological, or both. In fact, target or pathway-directed screens were originally used as a step in dereplication. You might purify all [easily discernable] components of a broth first [not so easy] and then test for antbiotic activity [this has been tried]- but the general observation is that useful novelty is hard to come by using kill-the-bug-screens against fermentations of standardly isolated organisms. So the key may be to look for generally non-isolated (or previously uncultivatable) organisms. And this is being done. Or use broad whole cell arrays of targeted screens. This should be done [has been attempted but natural product efforts have decreased in big and small pharma]. I do think it's worth doing efficiently on a big scale with serious experienced biology and chemistry support.
24. Morten G on March 12, 2009 2:13 AM writes...
@ 19 Thomas McEntee
Antibiotic resistant bacteria won't be the end of civilization so it's unfair to compare them to the calamity of an asteroid impact. If they were then how do you explain the existence of civilization before 1940?
And there are a tons of antibacterials right under our noses - that are also toxic to humans, that are photochemically labile, that are almost completely insoluble. So much useless crap in the world.
25. Resistant on March 12, 2009 9:47 AM writes...
Why do you think this area is low priority for the Pharma's. Can't really do much with it (from a discovery perspective) and, in the end people only buy 2 weeks worth of the stuff anyway.
26. Hap on March 12, 2009 10:03 AM writes...
There was life before 1940 - just a fair amount less of it (though not as much of it as I thought - about 15 years/person). Much of that is due to antibacterials. The people who are likely to have died of disease and infection are probably more widely spread in age, as well - so you were probably losing more of the productive people than the difference that life expectancy would indicate.
So civilization wouldn't end, but it would probably be less prosperous. And our parts in it would be shorter.
27. Brooks Moses on March 12, 2009 5:24 PM writes...
Thomas @19: I was reading something a couple of months ago (sadly, I can't recall where) that was reporting on the results of some research into antibiotic-resistant bacteria, and in particular on the encouraging fact that -- as one might hope for -- bacteria tend to quickly lose their resistance to antibiotics when the antibiotics go away. Genetics is nearly always tradeoffs, and when the antibiotic-resistant selection factor is removed, the costs of being antibiotic-resistant mean that the resistance is a hindrance and selected against. And bacteria being bacteria, they adapt quickly and lose it.
The biggest problem is of course in environments like hospitals, where certain antibacterials are pervasive.
28. srp on March 12, 2009 10:39 PM writes...
Brooks: If you can think of the reference for that article, I'd be interested. I've asked people about this question in the past and never gotten a clear answer.
BTW, I don't see why a small number of doses means that you can't profit from a drug. You should think in terms of price/cure = dose/cure*price/dose. When my flesh is being eaten by some parasite, my sales resistance is also way down.
29. milkshake on March 12, 2009 11:03 PM writes...
the difficulty is that there are too few patients that are sick enough to be treated with new antibiotics (and hence pay for the development cost). If a new antibiotics turns out to be broadly effective and without natural resistance, it is reserved by the medical community as the drug of last resort (so that the resistance development is held off as long as possible). By the time it becomes widely prescribed it will be off-patent already.
30. srp on March 13, 2009 8:31 PM writes...
My thought is that you can charge a super high price for a last-line-of-defense drug because whoever needs it really gets a huge benefit on the margin (of having it versus not having it). So even if they hold it back to the 2% of cases where the other stuff doesn't work you could charge 10-20X as much for it.
31. Punbutter on March 15, 2009 8:27 PM writes...
Affinium has a compound AFN-1252 in Ph1. This is a FabI inhibitor that I think was actually discovered out of the GSK program.
As for your future posts on the reasons for this difficulty, I recommend reviewing O;SHea dn Moser, . Med. Chem., 2008, 51 (10), pp 2871–2878
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Mr. Brown, as my username suggests I am very interested in Film and Television, to the point that I'm investing some time and money to learn as much as I can. I also share in the wonder and mystery of taking all sorts of ingredients and creating tasty miracles.
My fellow cinéastes and I have noticed that you rarely have the camera in a single place for more than a few seconds. You're always tracking, or panning. I also noticed that you like to use unusual angles (very high or low). Do you do this just to make it more fun or what? Lastly, (I promise) I wanted to know, what kind of camera you use for the shots from inside the fridge, paper bag, and oven. Is it a DV cam or do you use your regular camera?
Personally, I think you're show is great and worth watching because each episode has a plot, however simple or complicated (Ill gotten Grains, point in case, but that was one of the best ones!). There is always a reason why food must be cooked. Whether it is to rescue your "worthless hound dog" or to appease the "evil" stalker fan. Food with a mission, that sounds like, well you know, GE.
Sincerly, (or maybe not that sincerely),
Maria-Virginia D.
PS, the food scientist lady is sooo cute, she reminds me of my highschool English teacher![/COLOR]
Loved the Film Noir Butter episode!
Started by filmstudent , May 27 2004 10:11 AM
1 reply to this topic
Posted 27 May 2004 - 10:11 AM
Posted 01 June 2004 - 06:53 PM
Thanks for noticing all the camera work...i'm kinda proud of that. I do it because...well, everyone that works on the show (on the TV side) has done serious time in commercials and movies and we tend to treat every episode of Good Eats like a little movie. I direct them just as I did commercials...heavy on composition...and I've got a really great DP who does amazing things with light...really amazing.
As for gear, all our cameras are DVcam. The fridge shots are done on high end consumer camcorders and everthing else is done with either "prosumer" or professional cameras...but we master everything on mini DVs. .
As for gear, all our cameras are DVcam. The fridge shots are done on high end consumer camcorders and everthing else is done with either "prosumer" or professional cameras...but we master everything on mini DVs. .

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note: this issue seems the same as
When using class table inheritance with multiple levels i.e.:
Object -> SolidObject -> Building -> House
(House inherits from Building, Building from SolidObject, SolidObject from Object)
Object has the discriminator column and mapping. When persisting a new House entity I get a foreign key error because there is no row in the Building table.
I searched in the Code and found the problem. In the class "Doctrine\ORM\Persisters\JoinedSubclassPersister" in function "executeInserts()" around line 146 the array $subTableStmts is first declared and then filled with insert statements. The statement of the House-table is first added, and then the parent-tables (except the root-table "Object", since that one is executed first).
So the order in which the insert statements are executed is:
1 Insert into Object ...
2 Insert into House ... (which causes the error)
3 insert into Building ...
4 Insert into SolidObject
I edited the source to insert into the parent-tables (first SolidObject, then Building) before inserting into the table that belongs to the class that is persisted (House). And this works


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Capacity: 50 (theatre), 24 (classroom), 20 (conference), 36 (banquet/round tables)
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text: Double Down/NJ101.5 [ Are You Beautiful and Have Critics? -A Minute with Katie [AUDIO] By Dennis and Judi July 23, 2012 Here is the latest edition of "A Minute with Katie." Katie is Dennis and Judi's current screener who has interesting perspectives on life's toughest issues. Read More|Comment Category: Dennis & Judi, Talking About . . . Tags: Dennis and Judi, interesting views, Newsletter Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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General Psychology is designed to give the student an introduction to the concepts required for the study of perception, conditioning, learning, intelligence, motivations, emotions, and personality. The interaction of heredity and environment is also stressed. This course is a prerequisite to all other psychology courses. Prerequisite: English and Reading placement at college level.
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This week we talk about some new features that have been recently implemented by Linden Lab, we discuss new research that finds that virtual worlds can cause behavioral changes, we take a closer look at the role of art in Second Life, and more!
This week's topics include:
- Enhanced Avatar Physics
- Gogo's Physics Info and Free Layer
- Who created this version of Avatar Physics?
- Virtual Pregnancy and Legal Obligations
- New Marketplace Direct Delivery Beta Program
- New Second Life Sign-up Process
- Second Life Concurrency
- Crap's Suggestions to Grow Second Life
- Botgirl's Plan to Solve The Second Life Retention Problem
- Stanford Research Finds Virtual Worlds Can Cause Behavioral Changes
- Virtual Weight Loss
- New York Times Article on Avatars
- Responses to the NYT Article
- Linden Endowment for the Arts
- Month of Machinima
- AM Radio's Art SIMs
- Role of Art in SL/Price of Culture
- Linden Lab to Support Second Life Art (But First They Have to Define It)
- Inventing the Future of Games at USC Santa Cruz
- Ray Kurzweil on The Colbert Report
William Reed Seal-Foss (Reed Steamroller) is a 3D artist and virtual world content creator for Sand Castle Studios, LLC.
Bernhard Drax (Draxtor Despres) is a musician, new media producer, and machinima journalist.
Karl Stiefvater (Qarl Fizz, formerly Qarl Linden) is visual effects artist, software developer, and interactive designer extraordinaire.


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Winner of the 2012 New England Book Festival and Reader's Favorite Memoir Awards, and a Finalist in the 2013 Maine Literary Awards, The Box of Daughter is the compelling true story of the author's struggle to recover from childhood emotional abuse, and her quest to raise her self-esteem and create a more authentic life.
This captivating memoir offers many insights on the process of healing from Complex PTSD, describing the author's journey of recovery after growing up in a deeply dysfunctional family and illustrating how a person with Complex PTSD can make the leap from surviving to thriving.
In her twenties and thirties, the author pursued a professional acting career, appearing Off-Broadway, in independent films, and on the daytime drama Guiding Light. Entering therapy in her thirties in response to a divorce, she began to unravel the threads of dysfunction in her family.
More than a decade later, armed with the truth about her family, she sought to understand the challenges her parents faced and recover from the trauma while simultaneously acting as the family caregiver for her parents in their late 80s and early 90s. Freed from the abuse by the deaths of her parents in 2005 and 2008, the author began an inspiring journey to wholeness—developing self-esteem, uncovering her true self, and finally creating a life that is truly her own.
Katherine Mayfield is the author of Bullied: Why You Feel Bad Inside and What to Do About It, Dysfunctional Families: The Truth Behind the Happy Family Facade, Acting A to Z, and The Box of Daughter & Other Poems.
Signed copies can be ordered through the author's website.
This is the second edition of The Box of Daughter.
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text:
Hey all,
I don't own a WRX yet, but currently shopping the market. I currently drive a 94 Taurus SHO. May be looking to get into a WRX.
So, I will just be poking around reading up on this car.
Any tips in or things to look for when purchasing?


text: Clipart Reservation Dental Care Gets $3.3M Boost By Associated Press February 4, 2013 SIOUX FALLS - Dental care specialists hope a $3.3 million federal grant will help improve oral health on the American Indian reservations in South Dakota. Read More|Comment Category: Articles Tags: Dental, Health, Native Americans Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


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Fashion retailer to bring in 12 international brands-A A +A
Monday, March 10, 2014
HIGH-END fashion specialty retailer Stores Specialists Inc. (SSI) announced they are bringing in at least 12 new international brands in the country this year on the back of the strong retail infrastructure and thriving tourism and travel industries.
"The space at the moment is limited but there new malls being developed, which is a good sign that the market is ready to take more stores and international brands," said Anthony T. Huang, SSI executive vice-president.
Huang said the Cebu market is ready for more luxury brands given that its tourism industry is growing.
"We see a lot of tourists in your malls," he said.
SSI is a member of the Rustan Group of Companies, which operates shops in Metro Manila, Pampanga, Baguio, Cebu and Davao. The firm is the exclusive franchisee of more than 80 international brands, trading in 650 stores nationwide.
SSI recently opened the first F&F store in Cebu at the new wing of the Ayala Center Cebu. This British-inspired international brand offers a broad range of affordable fashion.
F&F Cebu is the store's fourth outlet in the Philippines. It opened first in Mindanao in General Santos City and Cagayan de Oro City.
Marcus Chipchase, F&F managing director told reporters they are eyeing to open at least 10 branches in the Philippines, with five of these located in Manila.
Chipchase said they are banking on the Philippines' large young population, which is a potential market for F&F.
"The response, so far, of the Philippine market is good. I can say, that we are meeting the expectations of the market, at the same time, we are learning to adapt to this new market as we move forward," he said.
F&F is owned and operated by multinational retail chain Tesco. In the Philippines, F&F is exclusively distributed by SSI. F&F has over 2,000 outlets worldwide and is present in 22 countries. It started in UK in 2001.
F&F designs are developed by their London-based designers who travel the world's fashion capitals to research looks and seasonal trends, the company said.
"What we are offering to Cebu is an affordable fashion from an international brand," said Chipchase.
Huang said the opening of F&F store in Cebu is an indication of a vibrant retail industry here.
"The Philippines has a very exciting retail market over the past years. Filipino consumers have become extremely sophisticated that has taken on well with international fashion and label as evidenced by the success of the brands that we brought here," said Huang.
"We definitely want to grow throughout the Philippines," he said.
Among the new international brands that will open next month in Manila are: Old Navy, Pottery Barn, Givenchy and Alexander McQueen.
Spanish-clothing brand Zara, on the other hand, will open its first outlet in Cebu next month. Zara has a network of 1,752 stores in upscale locations in the world's largest cities.
Healthy growth
Huang said SSI posted double-digit growth in the past three years. "This healthy growth is the reason we are expanding our business quite aggressively," he said.
Huang is optimistic the impending Asean integration in 2015 will open more opportunities for them.
"We have a strong retail network and infrastructure throughout the country. We are ideally positioned in the Philippine market as we expand more international brands here," said Huang.
"The benefit the Asean integration will bring to our industry is the fact that there will be whole lot more cross-border trade and therefore, a whole lot more cross-border travel and tourism that will increase the market size for the retail business not only in Manila but in other destinations like Cebu and the rest of the Visayas and Mindanao as well," said Huang.
Among the international brands carried by SSI are Lacoste, Armani Exchange, Bass, Ferragamo, Anne Klein, Nine West, Gucci, Prada, Polo Ralph Lauren, Kenneth Cole, Calvin Klein, Makeroom, Beauty Bar, and Lush.
Published in the Sun.Star Cebu newspaper on March 11, 2014.
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Weekly Legislative Review
Friday, February 3, 2012
On January 31st State Controller John Chiang sent a letter to the chairmen of the Senate and Assembly Budget Committees informing them that the state will run out of cash by early March if swift action is not taken to find $3.3 billion through payment delays and borrowing. State revenues are coming in $2.6 billion below the projections in the current year's budget while state expenditures are$2.6 billion higher than assumed. Together, these numbers "translate into a $5.2 billion reduction in cash resources," due mainly to overly-optimistic assumptions coupled with the difficulty in projecting revenues during times of economic uncertainty and high market volatility. The Controller projects that the "liquidity shortfall" will persist for seven weeks from February 29th to April 13th and he acknowledged that his suggested solution relies on still more borrowing, payment delays and deferrals but he believes it is the best way to manage the challenge without relying on IOUs or delaying tax refunds actions that can disrupt the delivery of essential public services and slow California's economic recovery.
SB 455 (Fran Pavley, D- Agoura Hills), which would create a voluntary watershed timber harvest permit (WTHP), passed out of the Senate this week. A WTHP would allow timberland owners to obtain 20- year permits to harvest their lands in return for maintaining their lands in timber production and managing them in a way to increase carbon sequestration. The bill is a work in progress and discussions will continue between the sponsors of the bill, The Nature Conservancy and Pacific Forest Trust, the forest products industry and environmental opponents.
In addition to the issues to be negotiated with regard to a WTHP, the bill also includes a requirement for mitigation for carbon losses from timberland conversions greater than one acre. Farm Bureau has expressed concerns over this new requirement and has asked for the conversion permitting requirements to be consistent with the existing requirement to obtain a timberland conversion permit for conversions of three acres or above. The bill passed out of the Senate with a vote of 21-3 and now moves to the Assembly.
At its Feb. 1 meeting, the Agricultural Labor Relations Board adopted regulations to implement Senate Bill 126 (Darrell Steinberg, D-Sacramento), approving them as proposed with only minor changes suggested by ALRB legal staff. SB 126 provides that if the ALRB sets aside a unionization election due to employer misconduct that affected the election's results, the ALRB must nonetheless certify the union to represent the employer's agricultural employees if the employer's misconduct "would render slight the chances of a new election reflecting the free and fair choice of employees." Farm Bureau associate counsel Carl Borden, who had testified on behalf of CFBF and other agricultural stakeholders at an earlier ALRB hearing on the matter, attended the meeting. All and all, the rules adopted were acceptable and do provide the adequate due process that Farm Bureau and other agricultural organizations had wanted included in the enabling legislation.
The regulations will be submitted to the Office of Administrative Law, which has 30 working days to approve or reject them. The ALRB will request that the regulations, if approved, go into effect upon their filing with the Secretary of State.
CFBF and 20 other organizations representing agricultural employers submitted comments on the proposed regulations.
Central Coast Regional Water Quality Control Board Conditional Agricultural Waiver Workshop. The Board held a workshop this week to assist newly appointed board members in gaining an understanding of the Conditional Agricultural Waiver renewal proposal currently before the board. The proposal will be considered for adoption as early as next month.
The Board heard testimony from stakeholders for seven hours in Salinas on February 1st. Regional board staff gave an overview of their proposal as well as their view of the problem. Representatives from the offices of Congressman Farr, Senator Blakeslee and Assemblyman Alejo provided testimony and voiced concern about the board's approach and process to date.
An agricultural panel that included Farm Bureau presented a voluntary coalition model to accompany and strengthen the detailed agricultural proposal submitted to the Board in December 2010. The model was developed by agriculture interests and Dr. Marc Los Huertos with CSU Monterey. California Farm Bureau and the seven county Farm Bureaus in the region worked with other agricultural organizations to develop the 2010 agricultural proposal. The workshop concluded in the evening after individuals from the local community, farmers, Monterey County Farm Bureau, Western Growers, the California Strawberry Commission and others gave public comment. The current Conditional Agricultural Waiver expires in September.
Governor Brown announced various appointments this week, a couple of which are of interest to agriculture. The Governor appointed, Brian Leahy, 55, of Sacramento, to serve as director at the California Department of Pesticide Regulation. Leahy has served as assistant director for the California Department of Conservation (DOC) since 2006. He was a partner at EcoFacilitation in the Netherlands in 2006, and served as executive director for the California Association of Resource Conservation Districts from 2004 to 2006. He was executive director at the California Certified Organic Farmers from 2000 to 2004. Leahy was owner and operator of Cherokee Ranch Inc. from 1980 to 2003 and also a farm operator for Ackerlund Farm Incorporated from 1992 to 1993. Leahy earned a Juris Doctorate degree from Creighton University School of Law. Farm Bureau has worked closely with Leahy on issues related to the Williamson Act during his tenure at DOC. This position requires Senate confirmation.
The Governor also announced the appointment of Lawrence Yee, 63, to serve on the Los Angeles Regional Water Quality Control Board. Yee held a variety of positions at the University of California Cooperative Extension from 1975 to 2008, including director of the University of California Cooperative Extension in Ventura County from 1986 to 2008. He was director of the University of California Hansen Trust established to sustain Ventura County agriculture through research and education, from 1993 to 2008. Yee received a Master of Business Administration degree from the Santa Clara University. This position also requires Senate confirmation.


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Call ScreenRedirect 12 phone numbers to a recording that tells callers you aren't taking calls at this time. Included with Call Privacy.


text:
Big Island residents awaken to magnitude-4.5 earthquake
Big Island residents woke up to a magnitude-4.5 earthquake that struck shortly before 6:30 a.m. Thursday near Kawaihae in South Kohala.
The U.S. Geological Survey Hawaiian Volcano Observatory reports the earthquake was located 3.4 miles east-northeast of Kawaihae. It was recorded at 6:24 a.m.
No tsunami was triggered by the earthquake, the Pacific Tsunami Warning Center says. The center registered the earthquake as a magnitude 4.2.
According to the USGS, the earthquake was felt in many Big Island districts, including South Kohala, North Kohala, Hamakua, North Kona, South Kona, Kaʻu, Puna, and areas of Hilo. Residents on Maui also reported feeling the temblor. A total of 145 people reported feeling the earthquake.
Over the past 50 years, the area around Kawaihae has experienced 11 earthquakes greater than magnitude-4.0, including Thursday's event, at depths of 6 to 12 miles. Deep earthquakes in this region are most likely caused by structural adjustments within the Earth's crust to accommodate the heavy load of Mauna Kea and surrounding volcanoes. Today's earthquake is in the general region of the 2006 Mahukona earthquake, but is not close enough to the 2006 event to be an aftershock of it.
Thursday's earthquake caused no detectable changes on the active volcanoes on the Island of Hawaii.


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Thursday, February 23, 2012
© Copyright 2015 Gwinnett Daily Post
SUWANEE -- North Gwinnett got a five-RBI night from Robert Pucciarello as the Bulldogs won their baseball season opener over Providence 11-2 on Thursday.
Pucciarello, who went 2-for-4, homered in his first varsity at-bat and also delivered a bases-loaded double to propel North to the win. Michael Haynes got the win for North by going five innings and allowing two earned runs and three hits while recording two strikeouts. Ben Carswell also went 1-for-2 for the Bulldogs.
Steven Slaughter took the loss for Providence (0-2) and allowed five earned runs on three hits in 2 innings of work. Patrick Smith came on for three innings of relief for the Stars and gave up just one earned run on three hits. Christin Stewart went 2-for-3 and homered for Providence, while David Rhodes was 1-for-1 in his first at-bat for Providence.
Duluth 4, Lovett 3
DULUTH -- Chris Rich hit a two-run homer as Duluth edged Lovett 4-3 in the season-opener for the Wildcats. Zach Erwin got the win by going four innings, striking out six and allowed no earned runs. Edward Willemse, who also went for 2-for-3 at the plate, got the save for Duluth. Noe Garcia added two hits for the Wildcats.
GAC 15, North Atlanta 9
NORCROSS -- Patrick Schultz went 2-for-3 and had a two-run homer and a triple as Greater Atlanta Christian defeated North Atlanta 15-9. Ross Wood also went 2-for-3 with a triple, while John LaMay was 2-for-4 and Greg Burland was 2-for-3 for the Spartans (2-0). Patrick Stone picked up with on the mound for GAC.
Mill Creek 4, Wesleyan 1
NORCROSS -- Mill Creek won twice in singles and doubles to defeat Wesleyan 4-1. Allison Weaver won at No. 2 singles and Abbi Jordan was victorious at No. 3 singles. Cailey Stevens and Mallory Kotts won at No. 1 doubles and Natalie Martinez and Jackie Zaczek won at No. 2 doubles for the Hawks (6-1).
Peachtree Ridge 4, Chattahoochee 1
JOHNS CREEK -- Peachtree Ridge got wins at No. 1 singles from Abby Owens and No. 2 singles from Jena Kelly to knock off Chattahoochee 4-1. Jessica Northcutt and Ali Mills won at No. 1 doubles and Rachel Anderson and Erin Mills won at No. 2 for Peachtree Ridge (2-0).
Mountain View 3, Hebron 2
DACULA -- Mountain View took two of three singles and got a win at No. 2 doubles as the Bears edged Hebron 3-2. Courtney Conway won at No. 1 singles and Emily Lopez won at No. 3 singles. Bri Norris and Veran Gogl took the win at No. 2 for Mountain View (3-0).
Sara Schmitt won at No. 2 singles and Savannah Blaylock and Ashley Whitten won at No. 1 doubles for Hebron (0-3).
Lanier 5, Monroe Area 0
MONROE -- Lanier didn't lose a game in the five matches played as the Longhorns blanked Monroe Area 5-0. Lauren Byrd (No. 1), Lindsey Wong (No. 2) and Meg McRee (No. 3) got wins in singles. Jenna Soucia and Victoria Inman (No. 1), and Carlie Overley and Nivein Gobran (No. 2) got the wins in doubles for Lanier (3-2).
Providence 4, Collins Hill 1
SUWANEE -- Providence swept the singles and also got a win at No. 2 doubles as the Stars defeated Collins Hill. Vani Crist at No. 1, Alex Schlesener at No. 2 and Abby Mazza at No. 3 picked up the wins singles, while Robin Serris and Carly Duvay paired up to win at No. 2 doubles for Providence (5-1).
Brookwood 3, Grayson 2
LOGANVILLE -- Liz Slaughter (No. 1) and Katie Kraft (No. 3) won in singles and Kenan Smith and Kerryn Roome (No. 2) got a win in doubles as Brookwood slipped past Grayson 3-2. Brookwood improves to 2-3 overall.
Berkmar 5, South 0
NORCROSS -- Berkmar defeated South Gwinnett 5-0 as the Patriots won all three singles and both doubles. Gabriell Chan (No. 1), Lan Tran (No. 2) and Dalena Nguyen (No. 3) got the wins in singles, while Linh Dinh and Elana Do won at No. 1 doubles and Amy Nguyen and Jenny Wong won at No. 2 doubles.
Archer 5, Apalachee 0
WINDER -- Archer took all three singles and both doubles as the Tigers shut out Apalachee 5-0. Sydnie Madison (No. 1), Kimberly Anderson (No. 2) and Sydney Sorensen (No. 3) won in singles and Caitlyn Balsamides/Lauren Dalton (No. 1) and Harper Emery/Madison Wyngaert (No. 2) won in doubles for Archer (3-2).
Brookwood 5, Grayson 0
LOGANVILLE -- Brookwood swept through the singles and doubles as the Broncos blanked Grayson 5-0. Will George (No. 1), Matt Jones (No. 2) and David Brown (No. 3) won in singles and Christian Gochnauer/Will McWhirt (No. 1) and Amarin Montry/Ryan Pridgeon (No. 2) took the wins in doubles for Brookwood (5-0).
Wesleyan 3, Mill Creek 2
NORCROSS -- Wesleyan took two doubles matches and got a key win at No. 2 singles as the Wolves got by Mill Creek 3-2. Jeffrey Chang got the win at No. 1 singles and Andrew Dorman/Zach Taylor won at No. 1 doubles and Brooks Prettyman/Palmer Brasher won at No. 2 doubles for Wesleyan (2-2).
Lanier 5, Monroe Area 0
MONROE -- Lanier swept all three singles and both doubles matches as the Longhorns rolled over Monroe Area 5-0. Hindhi Agenor won at No. 1 singles, while Kevin Wagner won at No. 2 singles and Kyle Galloway won at No. 3 singles.
In doubles, Gem Vang and Cullen Moss teamed up to win at No. 1 doubles and Derik Sadowski and Hjun Lee won at No. 2 doubles for Lanier (3-2).
Peachtree Ridge 4, Chattahoochee 1
JOHNS CREEK -- Peachtree Ridge swept the singles and also got a win at No. 2 doubles as the Lions downed Chattahoochee 4-1. Alex Makerenko won at No. 1, Jashith Chappara won at No. 2 and Kevin Lim won at No. 3 in singles for Peachtree Ridge (1-1), while Brock Beisel and Alex Peed got the victory at No. 2 doubles.
Collins Hill 5, Providence 0
SUWANEE -- Collins Hill improved to 6-0 as the Eagles blanked Providence 5-0. Singles wins by Chris Clark (No. 1), Tyler Kallgren (No. 2) and Ian Melnik (No. 3) led the way for Collins Hill. The Eagles also got wins in doubles from Alec Rahmanian/Marcus Maloney (No. 1) and Evan Padvorac/Josh Jackson (No. 2).
Berkmar 4, South 1
NORCROSS -- Berkmar swept singles and won at No. 2 doubles as the Patriots defeated South Gwinnett 4-1 at Hudlow Tennis Center. Jimmy Nguyen won at No. 1 singles, Chang Wei You won at No. 2 singles and Anthony Aguilera won at No. 3 singles for Berkmar (2-1). Kevin Deane and Kevin Tran paired up to win at No. 2 doubles for the Patriots. Chas Reid and Che Estes got South's lone win at No. 1 doubles.
Hebron 3, Mountain View 2
DACULA -- Jerod Beck and Josh Beck picked up wins at No. 1 and 2 singles, respectively, and Justin Starner and Johnell McLean won at No. 1 doubles to lead Hebron to a 3-2 win over Mountain View. Hebron improves to 2-0 for the year.
Archer 3, Apalachee 2
WINDER -- Archer took two of three singles and got a win at No. 2 doubles as the Tigers defeated Apalachee 3-2. Aaron Harris won at No. 1 singles and Alex Butenko won at No. 2 singles.
Josh Cade and Jordan Wyton teamed up to win at No. 2 doubles for Archer (3-1). Clayton Edenfield won at No. 3 singles and Brandon Tovar-Lee Vue got the win at No. 1 doubles for Apalachee (2-1).
North 8, East Coweta 4
NEWNAN -- Matt Palmer, Luke Printz and Joe Whitaker all scored two goals each as North Gwinnett topped East Coweta 8-4. Alex Riggin came up with four saves in goal, while Ronnie Adams had six shots and also recorded a goal for North (2-0).
Mill Creek 27, Norcross 1
NORCROSS -- Alexis Ordini had eight goals and two assists as Mill Creek pounded Norcross 27-1. MacKenzie Fagioli added four goals and two assists, while Noelle Allen had three goals and three assists for Mill Creek (2-0). Tori Windom also had three goals and Nicole Gump had three goals and an assists for the Hawks (2-0).
Mountain View beats Lanier
HOSCHTON -- Blake Padilla had a 45 to lead Mountain View (2-0) to a 196-226 win over Lanier at Reunion. James Hughes had a 46 for Lanier.
Providence rolls past Shiloh
LAWERENCEVILLE -- Colin Grant fired a 38 as Providence improved to 2-0 with a 194-241 win over Shiloh at Northwood Country Club.
Peachtree Ridge slips by North Gwinnett
SUWANEE -- Michael Chong carded a 38 as Peachtree Ridge edged North Gwinnett 161-167 at Bear's Best. Sam DiPaola had a 40 to lead North Gwinnett (0-1).
Mountain View tops Lanier
HOSCHTON -- Morgan Foley had a 51 as Mountain View (1-1) defeated Lanier 105-126 at Reunion. Brittany Mosley led Lanier with a 61.
GAC 3, SINE School 0
NORCROSS -- Greater Atlanta Christian got goals from Rachel Garcia, Halle Huff and Abbie Abrahart en route to a 3-0 over the SINE School of Denmark. Jamie Campbell, Kelsey Fervier and Garcia each had one assist for the Spartans (1-0). Elizabeth White got the shutout in goal for GAC, making four saves on the night.
Buford 3, Calvary Day 0
SAVANNAH -- Baxter Argo had four saves and got the shutout in goal and Esgardo Arroyo had two goals as Buford blanked Calvary Day 3-0. Christian Lopez added a goal and Jesus Deleon had an assist for the Wolves (3-0).
Central 4, Walnut Grove 1
LOGANVILLE -- Tyler Budd and Samir Ramic each had a goal and an assist as Central Gwinnett defeated Walnut Grove 4-1. Juan Gonzalez and Brayan Herrera also had one goal each for Central (2-0-1). Charlie DeLoatch got the win in goal for the Black Knights.
-- Compiled by Steve Argo
More like this story
- PREP ROUNDUP: Duluth boys edge Mill Creek on penalty kicks ( March 20, 2012 )
- PREP ROUNDUP: Felt strikes out 12 in no-hit win for Hebron ( March 15, 2012 )
- PREP ROUNDUP: Hebron pitchers combine for no-hitter ( March 22, 2012 )
- PREP ROUNDUP: Eagles' Askew tosses shutout ( March 7, 2012 )
- PREP ROUNDUP: Wesleyan duo shuts down St. Francis for 5-A win ( March 29, 2012 )


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Oasis of the Seas
Oasis of the Seas offers a cruise like no other
Ship Review by Matt Roseboom, November 2009
Royal Caribbean's Oasis of the Seas, the largest cruise ship in the world, recently made her much anticipated debut at her home port in Ft. Lauderdale. Oasis is unlike other ships in more ways than one. She sets a new standard in cruising.
If you view the ship from the top or back, you'll see her unique design. The ship is seemingly split down the middle with cabins that look down from both sides to the Boardwalk (complete with a carousel) on Deck 6, and Central Park on Deck 8. That's right, this ship has a Boardwalk and a real park. If you've been on any of Royal Caribbean's other newer ships, you'll recognize the Promenade as the mall-like open space down the center of the ship. On the Oasis it's nearly twice as wide and has an added mezzanine level. It's here you'll also find The Rising Tide Bar. It's just that — a bar that moves up and down between the Promenade deck and the Central Park deck.
Even though it's the largest cruise ship in the world, the open decks make it easier to find your way around than on ships where every deck looks alike. And if you do get lost, just tap your destination on the large touch screens near each elevator. It'll show you a mapped route to get to your destination. You really can't tell how large the ship is until you visit the Pool and Sports Zone on Decks 15 and 16. Stand near the center on these decks and you'll barely be able to see the ocean on either side. The ship has room for up to 6,296 guests.
Forget dining at your assigned table in the main dining room. Although Oasis offers that, you have your choice of 15 complementary dining options, nine specialty restaurants with a cover charge and two a la carte treat shops. After dinner you have as many options. There's a dedicated comedy club, an ice skating rink, a jazz club, disco and more. You'll need tickets to many of the shows, including the main show room (where you can see a live performance of "Hairspray"). Tickets can be reserved before your cruise or onboard from your stateroom TV. Unique to the Oasis is the Aquatheater. Located at the end of the Boardwalk, this open air theater can transform from a swimming pool and sun deck, to a stage or movie theater. But it was designed for their signature shows, which feature high divers, trampoline artists and synchronized swimmers. Again it's unlike anything else at sea.
Look above the Boardwalk and you'll see guests ziplining 82 feet across the open area of the ship – nine decks above your head. Thrill-seeking guests can also climb either of two large rock-walls or surf in one of two Flowriders.
These are just the highlights of Oasis. Once aboard you'll discover many more innovations. You may have heard cruise ships referred to as cities at sea. No other ship comes as close to that as Oasis of the Seas.
|Spa / Wellness / Fitness
|Public Rooms
|Children / Teens
|Other Facilities / Services
4 Responses to "Oasis of the Seas"
I just found this site a while back when a friend of mine recommended it to me. I've been an avid reader ever since.#4422
We would like to go on a cruise(particularly this ship) but we're worried that we can't fax or scan business documents. We need to use our laptop for skype. You listed business center services here on this list above. What does that entail? And do you think the internet connection is good enough for skype?#9602


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In a tongue-in-cheek ad opposing Arizona's immigration law, the Service Employees International Union is campaigning not only to promote a cause, but to build a list.
One of the nation's most prominent unions is running an online-only ad campaign that uses parody to oppose what it calls anti-immigrant laws like the immigration law recently passed in Arizona. A secondary goal: collect mobile phone numbers. The Service Employees International Union is doing what a lot of advocacy organizations are finding to be a valuable strategy - campaigning not only to promote a cause, but to build a list.
With the help of digital consulting firm Revolution Messaging, the SEIU is taking a unique approach to readily solicit cell phone numbers by promoting an 800-number in display and search ads. "Before you travel to Arizona, call the travel advisory hotline" declare ads running in Google's display network since last Monday. The ads link to ItStopsInArizona.org, a site featuring a petition opposing the immigration law passed in Arizona in April, along with similar legislation in other states, and supporting comprehensive federal immigration reform.
Related search ads are targeted to keyword terms such as "Arizona immigration law" and "immigration reform."
Dialing 1-800-958-9068 alerts callers that if they're considering a visit to Arizona, they should beware of the "overly stringent" immigration law. "If you plan to wear jeans, press one," commands the automated voice on the other end of the line. "If your skin is even remotely tanned, yellow, brown or blue in hue, press two." The caller is told to visit ItStopsInArizona.org, or, if calling from a mobile phone, to press a button to receive text alerts on that device.
In this way, the 1-800 number element of the campaign becomes especially important because it enables SEIU to easily capture mobile phone numbers.
"We're going after people who are outraged...and support comprehensive immigration reform," said Joaquin H. Guerra, SEIU new media campaign manager. "We're trying to pick up on this outrage using satire and parody."
Employing a cause-related campaign to build a supporter list which can then be used for future efforts is becoming increasingly common among nonprofits and advocacy organizations. Earth Day Network, for example, promoted a Climate Rally in Washington, D.C., in April in conjunction with this year's Earth Day. The organization ran homepage takeovers on DailyKos.com, in addition to ads on environmental and political blogs and newspaper sites, promoting the rally. But the campaign also served to generate thousands of new contacts for a somewhat stale supporter list.
"We wanted to achieve as many new members in our database as humanly possible," Nate Byer, Earth Day Network campaign director told ClickZ in April. "We wanted to revitalize it." The group generated 20,000 additional contacts on Earth Day alone as a result of the campaign.
SEIU was one of many Earth Day Network partners that sent e-mails to its members promoting the climate rally. The union represents workers in service industries such as healthcare workers and public service employees, and counts immigrants as a third of its membership, according to Guerra. He said the union is spending a "significant" amount on its online-only ad effort. The SEIU chose not to run any print, radio, or television ads - media in which such direct-response campaigns are common.
The SEIU has collected "tens of thousands" of mobile phone numbers through the Arizona immigration law campaign. The group is using the phone numbers to organize supporters across the country for rallies - like the one held in Washington, D.C. on June 3, coinciding with Arizona Governor Jan Brewer's visit to the White House. It is also sending text messages urging supporters to contact their representatives in Congress, and alerting them to breaking news.
Follow Kate Kaye on Twitter at @LowbrowKate.
Subscribe to ClickZ's Politics & Advocacy News RSS feed.
Download ClickZ's free
Digital Political Campaigns 101
resource today!
Kate Kaye was Managing Editor at ClickZ News until October 2012. As a daily reporter and editor for the original news source, she covered beats including digital political campaigns and government regulation of the online ad industry. Kate is the author of Campaign '08: A Turning Point for Digital Media, the only book focused on the paid digital media efforts of the 2008 presidential campaigns. Kate created ClickZ's Politics & Advocacy section, and is the primary contributor to the one-of-a-kind section. She began reporting on the interactive ad industry in 1999 and has spoken at several events and in interviews for television, radio, print, and digital media outlets. You can follow Kate on Twitter at @LowbrowKate.
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The term acupuncture describes a family of procedures involving stimulation of anatomical points on the body by a variety of techniques. The acupuncture technique that has been most studied scientifically involves penetrating the skin with thin, solid, metallic needles that are manipulated by the hands or by electrical stimulation.
|SOURCE The Academy of Oriental Medicine at Austin
Copyright©2007 PR Newswire.
All rights reserved


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Nokia Rich Recording consists of a set of microphone technologies that provide audio recording at CD-like levels of quality. It captures true stereo sound and the whole audible frequency range just like you hear it. Also, Nokia Rich Recording allows distortion-free recording in very loud environments (up to 145 dB).
What is Nokia Rich Recording?
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Norwalk's "first family of arm wrestling" has made the leap to prime time almost. A pilot of a reality series based on the Reagan family was posted on YouTube.com last month.
Twenty-one-year-old Boomer Reagan is a prodigy of arm wrestling who has beaten national and world champions. He is ranked highly in both professional and amateur arm wrestling. Last year, Reagan qualified for the 2006 Arnold Scwarzenegger Classic which arm wrestlers covet more than a world championship title, according to Boomer's father, Willie, a.k.a. Pork.
Willie, who is also highly ranked, coaches his son and travels with him to tournaments throughout the country.
Boomer is a member of the Norwalk-based PowerHouse arm Wrestling Team, which includes Willie and others Boomer's age.
The show also features family members, mom Julie and kid sister Kiersten, as well as Boomer's fiance, Devon.
The production company, Red Line Films, approached the Reagans after they appeared in an ESPN documentary about various sports called "Timeless."
Red Line is currently shopping the show to the major networks and they have had some interest, Julie Reagan said. Whether it is actually put on the air, however, is a question of when the networks have the right hole in their schedule. "It could be a month from now. It could be a year from now," Julie said.
Of course, if the video gets a lot of buzz on YouTube, that won't hurt the cause.


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Celeb-inspired gift guide: dad Jack Osbourne
Celeb-inspired gift guide: dad Jack Osbourne
Virgin Active membership
For dads who talk a lot about going to the gym but never actually get round it, this is the perfect gift. Buy them a membership to Virgin Active to kickstart their exercise regime in the New Year. For all you London dwellers, Virgin Active Kensington has the best facilities and equipment around.
Visit virginactive.co.uk for more details


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Welcome to Smogon! Check out the Smogon Info Hub for everything you need to know about starting out in the community. Don't forget to introduce yourself in the Introduction Thread, too!
Welcome to Smogon Forums! Please take a minute to read the rules.
Pocketman: a short story of a pervert
Discussion in 'Smogon's Greatest Hits' started by The Undertaker, Jul 10, 2008.


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Caitlin is a Christian author who loves learning and aspires to use the powerful tool of storytelling for God's glory.
She had the privilege of being home-schooled and is very grateful for the unique opportunities this gave her to grow close to her family and learn how the Bible applies to all of life. It also provided the perfect scenario for her to develop her love of writing and begin her first full-length novel, which was published under the title Baker Family Adventures: Summer of Suspense. The sequel, Peril on Providence Island, was released last year.
Both of the books, as well as the next two installments in the series, Riddle of the Ruby Ring and The Treacherous Trail, are available here.
She lives in England's picturesque county of Hertfordshire, and is happiest when playing in classical concerts, travelling with family and friends, stumbling across new story ideas, or tapping action sequences into her trusty laptop. Connect with her on Facebook here.


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At ADEX Medical Staffing, LLC we pride ourselves on providing highly qualified and experienced medical professionals. We have designed innovative compensation plans that help you better manage your staffing costs. For example, we've established a pricing structure that lets you pay medical imaging technologists by the scan instead of by the hour. This – more... ensures that procedures are done in the most time-effective way, resulting in a lower costs per patient. Our network of local offices means you always get the service you deserve.
Here is a partial list of hospitals and other medical facilities we are currently working with:
All About Staffing
AzHHA - Service Corporation – less–ZoomInfo


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Archives: Thanksgiving
Apple Cranberry Currant Crumble PieApple crumble pie with sliced apples, dried cranberries and currants, in a buttery crust with a brown sugar streusel topping.
Apple Cranberry PieThis apple cranberry pie is one of our favorite pies to make for Thanksgiving or the holidays! Flaky buttery crust, spiced apples mixed with dried cranberries and brandy.
Apple PieHomemade apple pie with a flaky pie crust and sliced apples, sugar, allspice, nutmeg, cinnamon, vanilla and brandy
Bourbon Mashed Sweet PotatoesSweet potatoes, boiled in water, mashed and mixed with bourbon whisky, butter, and sugar.
Brandied CranberriesFresh cranberries baked with sugar, brandy, and orange zest.
Brussels Sprouts with Bacon and ChestnutsThinly sliced brussels sprouts sauteed with bacon and onions, then tossed with roasted chestnuts, thyme and a little lemon juice.
Brussels Sprouts with Toasted AlmondsSimple and delicious Brussels sprouts recipe with lightly steamed or boiled sprouts, mixed with sauteed onions, butter, and toasted almonds.
Butternut Squash Apple Cranberry BakeSimple and easy butternut squash, apple, and cranberry bake recipe. Perfect for a holiday feast.
Butternut Squash with Browned Butter and ThymeCubed butternut squash, cooked on the stovetop with browned butter and thyme.
Butternut Squash with Walnuts and VanillaButternut squash with butter, ginger, walnuts, thyme, and vanilla.
Caramel Nut TartDo you love nuts? This nut tart recipe combines walnuts, pecans, and almonds, in a caramel filling, served in a buttery crust.
Chiffon Pumpkin PieA truly special pumpkin pie with a jelled pumpkin and meringue filling and a gingersnap cookie crust.
Classic Baked Acorn SquashEasy baked acorn squash recipe, perfect for the fall. Squash is cut in half, insides scooped out, then baked with a little butter, brown sugar, and maple syrup.
Cranberry ApplesauceHomemade cranberry applesauce made with apples, fresh cranberries, lemon juice, sugar, and cinnamon.
Cranberry RelishHoliday and Thanksgiving Cranberry Relish recipe. Fresh cranberries ground up with apples and orange. Great with turkey sandwiches.
Cranberry SauceClassic, easy and delicious Thanksgiving cranberry sauce recipe. How to make cranberry sauce from scratch. Perfect with turkey.
Creamy Scalloped PotatoesDelicious scalloped potatoes, thinly sliced potatoes baked with butter, bacon, onion, chives, parsely, Gruyere, Parmesan and cream.
Creamy Sweet Potato SoupCreamy sweet potato soup with red-skinned sweet potatoes, cooked in stock with onions, celery, and leek, pureed and seasoned with cinnamon, nutmeg, and maple syrup.
Giblet GravyClassic gravy made with the giblets (neck, liver, heart, gizzard) from a turkey or chicken.
Green Beans with Almonds and ThymeRecipe for green beans, boiled first, then sauteed in butter with thyme and toasted almonds.
Green Beans with Shallots and PancettaQuick and delicious green beans recipe with fresh green beans, shallots, and pancetta.
Holiday Spiced Sweet Potatoes (Yams)Garnet yam sweet potato recipe, pureed garnet yams with butter, brown sugar, and holiday spices. Perfect for Thanksgiving.
Hot Turkey SandwichHot turkey sandwich. The easiest way to prepare turkey leftovers, as an open-faced sandwich, topped with leftover turkey and gravy.
Indian PuddingTraditional American Indian Pudding, a baked custard pudding made with cornmeal, milk, eggs, and sweetened with molasses. Perfect for Thanksgiving!
Maple Orange Glazed CarrotsRounds of carrots, sautéed in butter and glazed with maple syrup and orange juice. Perfect for the holidays!
Maple-Glazed Yams with Pecan ToppingSliced, baked sweet potato yam recipe, with maple syrup, brown sugar, and pecans.


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1. Katharine McPhee - Over the Rainbow
Alfred is pleased to present the sheet music for Katharine McPhee's version of the classic song "Somewhere Over The Rainbow." "Somewhere Over The Rainbow" is McPhee's debut... more info$3.95 add to cart
Usually ships within 4-5 business days
Sheet. Original Sheet Music Edition. With Sheet. 6 pages. Published by Alfred Publishing. (AL.00-26213)
2. Over It
Sheet music. more info$3.95 add to cart
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Piano Vocal. Arrangements for piano and voice with guitar chords. 9x12 inches. 10 pages. Published by Hal Leonard. (HL.00353621)


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- Infowars - http://www.infowars.com -
Gates Talks of Rapid Troop Increase in Afghanistan
Posted By admin On December 11, 2008 @ 2:44 pm In Old Infowars Posts Style,World at War | Comments Disabled
The New York Times
December 11, 2008
KANDAHAR, Afghanistan — Defense Secretary Robert M. Gates said here on Thursday that the Pentagon, which plans to send 20,000 additional troops to Afghanistan, was trying to get thousands of them into the country as soon as next spring, a sign of the seriousness of the threat by the Taliban.
The soldiers were requested by Gen. David D. McKiernan, the top commander in Afghanistan. The first of them, about 3,500 to 4,000 troops from the Third Brigade of the 10th Mountain Division from Fort Drum, N.Y., are scheduled to arrive in Afghanistan next month.
Mr. Gates said he hoped to deploy an additional two combat brigades by the spring as part of an effort to combat growing violence and chaos in the country. Pentagon officials have said it would take 12 to 18 months to get all 20,000 troops to Afghanistan. The United States currently has some 34,000 troops in the country.
Both Mr. Gates and General McKiernan also said Thursday that there would be a "sustained commitment" of American troops in Afghanistan for the next three or four years, although they declined to put a number on that commitment.
Article printed from Infowars: http://www.infowars.com
URL to article: http://www.infowars.com/gates-talks-of-rapid-troop-increase-in-afghanistan/
Click here to print.
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A beautiful, colourful mark that uses a simple repeating pattern to make an impact. I love the way the bright colours draw your eye around the symmetrical shape of the mark.Posted in Branding → Logo
An interesting replacement icon for the Tor Browser that uses the onion concept but takes a cleaner approach.Posted in Branding → Logo
A remarkably simple concept that uses line and colour to form a distinctive and unique image. The strong sense of coherence will help to make this logo identity a solid foundation for a brand.Posted in Branding → Logo
Ross'n Ford make short company movies. They film and make their own music. The concept is pretty simple, R+F monogram and a musical notation turned into a pellicle (film). This is apt since Ross is the guy behind the music and Ford the film maker.Posted in Branding → Logo
A beautiful logo design that uses bright colours to attract attention. I love the symmetry of the shape, and the way the colours work together.Posted in Branding → Logo
An intriguing logo design variation on the BoldMedia branding. I love the use of colours and the way the symmetry creates an instantly recognisable mark,.Posted in Branding → Logo
I love the use of colours here, they really help to make this logo memorable. The curvature and sense of perspective help to set this logo design apart.Posted in Branding → Logo
What can I say? An absolutely stunning logo for a new Mac app. I love the vivid colours and simply jaw dropping design. It simply 'works'.Posted in Branding → Logo
A bright and vibrant logo for a design company! I love the slogan \'Colour Your Life\' and how it is represented here using the whole spectrum of potential colours. The bold impact of the letter V is enhanced by nice details, such as the fold line and sharp angles.Posted in Branding → Logo


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Mark Tomasik: Former manager Sparky Anderson made most of his stop in the Florida State League
Sparky Anderson's Hall of Fame managerial career, shaping the Cincinnati Reds and Detroit Tigers into championship clubs, might never have happened if not for a year in the Florida State League that significantly enhanced his reputation.
Anderson, who died Thursday at 76, had been fired as manager of Toronto of the Class AAA International League after the 1964 season. He had led Toronto to an 80-72 record, but he was considered hot-tempered. No other offers came. At 30, after just one season, his managerial future appeared cloudy.
Then in March 1965, Fred Koenig resigned as manager of the St. Louis Cardinals' Class A Rock Hill team in the Western Carolinas League. With the start of the season near, St. Louis general manager Bob Howsam was scrambling to find a replacement for Koenig.
Howsam contacted Los Angeles Dodgers executive Dick Walsh for advice. Walsh recommended Anderson, who had played in the Dodgers' minor league system. Howsam took a chance.
The Cardinals didn't stock Rock Hill with top prospects. The best players were two future major league pitchers — Sal Campisi and Jerry Robertson — and third baseman Len Boyer, younger brother of big leaguers Ken and Clete Boyer. (Displaying a knack for the hyperbole he later became noted for, Anderson predicted Len Boyer "has the best potential of the family.")
Anderson managed Rock Hill to a 59-63 record.
In 1966, the Cardinals named Anderson manager of St. Petersburg, in the better caliber Class A Florida State League.
After an 0-5 start, St. Petersburg won 22 in a row, shattering the league's consecutive wins record of 15 established by Daytona Beach in 1950.
The streak was broken on May 21 when the Cocoa Astros beat St. Petersburg, 1-0. "The kids seemed like they didn't want to believe it was over," Anderson told The Sporting News. "I had to say, 'Come on, let's get in the clubhouse.' "
The streak wasn't the only amazing thing that happened to Anderson and his team that season.
In a game that began on June 14 and ended at 2:30 a.m., on June 15, the visiting Miami Marlins beat St. Petersburg, 4-3, in 29 innings. "It was the darndest thing I've ever seen," Anderson told The Sporting News.
It also was the longest game, by innings, in the history of organized baseball. The game took 6 hours, 59 minutes. It began with a crowd of 750, and ended with about 600 less.
The score was 2-2 after nine innings. Each team scored in the 11th. Miami left-hander Paul Gilliford pitched 11 scoreless innings of relief and didn't get the decision.
A sacrifice fly by Carl Cmejrek with the bases loaded in the top of the 29th scored pitcher Mike Hebert from third. Hebert retired St. Petersburg in order in the bottom of the inning.
St. Petersburg, led by future major league pitchers Clay Kirby and Harry Parker, went on to a 91-45 record. Anderson was named the league's all-star manager and strengthened his reputation within the Cardinals' organization as a first-rate instructor.
In January 1967, Howsam left St. Louis to become general manager of the Reds. The Cardinals named Anderson manager of Class A Modesto of the California League. Three of his Modesto players — Kirby, reliever Ed Sprague and catcher Bill Plummer — later would play for him with the Reds.
Anderson led Modesto to a 79-61 mark and the league championship.
In the fall of 1967, Howsam wooed Anderson into the Reds organization as a minor league manager at Class AA Asheville. Two years later, on Oct. 9, 1969, Howsam introduced Anderson as manager of the Reds.
He won the National League pennant in his first season at Cincinnati, and from there built one of the legendary managerial careers in major league history.
Mark Tomasik is the editor of Scripps Treasure Coast Newspapers. This column reflects his opinion. He can be reached at email@example.com.
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Engineered Garments FW11 Lookbook
—01. Should start to deliver in mid-August.
The Engineered Garments FW11 has just recently made its way online, and around the internet in no time. It's one of my favorite look books from the New York based brand, with great timing, the art work in the Nepenthes NY store turned out to be a great back drop for the colors in the collection. With lots of wools, a bit of floral, some new styles and some classics - it is a very strong fall collection, coming soon. There are even several styles not even featured in these images that were some of our favorites of the offering as well, so keep an eye out for a couple new pieces of outerwear from Daiki this fall.


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I wish I could get excited about this one.
A big-screen adaptation of last year's PlayStation 3 survival horror game "The Last of Us" is on its way, which should be exciting for fans of The Walking Dead, survival horror and anything George Romero ever touched or influenced.
I'll bet a lot of die-hard fans of the game itself have a somewhat subdued sense of excitement, though, as concerns that no full-length feature film could properly capture the game's story are valid. Full disclosure: "The Last of Us" was the last game I played on my PS3 before I sold the system and made room for the PlayStation 4. Between having a life, playing the game on "hard" difficulty and the Yellow Light of Death felling my aging system twice before I could finish it, I lived the story of Joel and Ellie for months, so I got pretty invested in the storyline.
Even if you blaze through the game quickly, it'll still take you about 20 hours to give it an honest play-through, and if the movie hews faithfully to the game, we're looking at a number of character development threads that can't be captured well in a movie. The beauty of "The Last of Us" is its reliance on a slow-burn method of getting us acclimated to characters hours at a time, only to lose them in many cases. Since a film version would be two-and-a-half-hours or so on the long end, I can't see how the movie wouldn't come off as a hack job.
The only promising news I've read about the movie is the possibility that Game of Thrones ass-kicker Maisie Williams could get the role of Ellie, which means that Sony is at least taking casting seriously. But would the screenwriters have the balls to put Ellie in a somewhat ambiguous same-sex relationship, like the game's "Left Behind" downloadable content did? Also, keeping the game's excellent controversial ending intact would be nice, but would filmmakers shy away from it since it doesn't fit into the tidy Hollywood aesthetic?
We're all kinda going through zombie fatigue right now, much like the vampire fatigue that preceded it. If "The Last of Us" film winds up being just another zombie chase with little gleams of soul here and there, it'll justifiably leave theaters just as soon as it gets there and wind up in Best Buy's bargain bin. But it wouldn't dilute the awesomeness of the game itself, as there have been a plethora of shitty movie adaptations of great video games that people still love.
Sure, it makes sense for Sony to turn "The Last of Us" into a film that would likely bring in a nice opening weekend haul from fans of the game alone. But I sure hope I'm wrong about the final product…lets just say my breath is not exactly bated.
Consider posting a comment.


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Reviews, reviews, reviews...
FreakScore is a weighted average of all aggregated professional and user review scores.
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out of 10 based on 20 scores.
VSX-52 No system you've had before quite prepares you for the st
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Best Price at Amazon


text: Jimmie Lou Fisher (born December 31, 1941 in Delight, Arkansas), is the longest serving Arkansas State Treasurer in Arkansas history, grew up in Paragould, Arkansas. She attended school at Delaplaine School in Delaplaine, Arkansas. She, at a very early age, became interested in politics, and aspired to be successful. She graduated from Vilonia High School, and attended Arkansas State College in Jonesboro, Arkansas, and after graduating went on to hold a number of jobs, and was a party activist for over a decade. She has described herself as lifelong, diehard, yellow dog Democrat. [1]Wikipedia


text: Woman Unmasks Burglar: It's Her Grandson Just as she suspected By Matt Cantor, Newser User Posted Jun 18, 2013 8:48 AM CDT STORY COMMENTS (68) (Newser) – An Albuquerque grandmother thought she recognized a masked burglar who entered her home on Friday morning—and when Pamela Dearinger managed to rip off his bandana, her suspicions were confirmed: It was her grandson, police say. Thomas Clark, 22, came in through the back door while she was watching TV, she says; he grabbed her, and that's when she pulled off the bandana. He knocked her down and stole her purse—Dearinger pegged the value of it and its contents at $507—before fleeing, reports the Albuquerque Journal. Police caught up with him at his parents' house several hours afterward, KRQE reports. Why the desperate need for cash? Police say Clark told them his friends suggested it would be a great way to fund a trip to a nearby casino. Worse still, he's broken in once before to steal a TV, his grandmother says in the criminal complaint. Clark now faces felony charges. His grandmother was bruised and received cuts to her wrist and mouth in the altercation, but she says she's OK. A grandmother pulled off a burglar's bandana (it was actually purple) to find it was her grandson. (Shutterstock) ADVERTISEMENT(Click Prev or Next to continue viewing images.) « Prev« Prev | Next »Next » Slideshow KRQE (Albuquerque) (Source Grid ») Albuquerque Journal (Source Grid ») Crime & Courts • Great Finds burglar • Albuquerque • grandmother CLICK BELOW TO VOTE 6% 2% 76% 2% 6% 8% RETURN TO THE STORY To report an error on this story, notify our editors.


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Shades of Gray
A Loveswept Classic Romance
(If any tax is payable it will be calculated and shown at checkout.)
Preview (read now) Add to my own site Give this ebook to a friend Add to my wishlist Author's page Publisher's page
morePower is the ultimate aphrodisiac. But in this classic novel of romance and suspense from New York Times bestselling author Kay Hooper, a strong man who always takes what he wants is challenged by an alluring woman who is not easily kept.
Ruthless, charismatic, and devastatingly handsome, Andres Sereno rules the small South American island of Kadeira with an iron first—and he has abducted the irresistible Sara Marsh to keep her out of harm's way. Of course, Andres has ulterior motives: He is determined to convince Sara that she cannot live without him. Overwhelmed by his urgent desire, Sara finds Andres hard to resist. But can she trust a man with darkness in his soul and danger in his blood?
Blindsided by a sudden storm with no safe harbor in sight, Sara has no choice but to embrace the fierce warrior who holds her captive. Though Andres tries to shield her from his violent side, Sara knows that she's tempting fate. Before risking everything, Sara must walk through fire and discover the strength within herself. Only then can she surrender to the primitive force of their desire. less
Random House Publishing Group; November 2012
176 pages; ISBN 9780345539618
Download in secure EPUB
Title: Shades of Gray
Author: Kay Hooper
176 pages; ISBN 9780345539618
Download in secure EPUB
Title: Shades of Gray
Author: Kay Hooper
Buy, download and read Shades of Gray (eBook) by Kay Hooper today!
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