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Serratia marcescens
Alias: "Bacillus marcescens" (Bizio 1823) Trevisan in de Toni and Trevisan 1889, Bacillus marcescens, Serratia marcescens Bizio 1823, Pantoea sp. NAB7
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Publications156 found, 100 shown here
- [Post-marketing surveillance of antibacterial activities of cefozopran against various clinical isolates--II. Gram-negative bacteria]Jun Igari
Department of Clinical Pathology, Juntendo University, School of Medicine
Jpn J Antibiot 55:22-60. 2002..n = 192), Klebsiella oxytoca (n = 157), Enterobacter cloacae (n = 189), Enterobacter aerogenes (n = 93), Serratia marcescens (n = 172), Serratia liquefaciens (n = 24), Citrobacter freundii (n = 177), Citrobacter koseri (n = 70), ..
- Antimicrobial susceptibility of respiratory isolates of Enterobacteriaceae and Staphylococcus aureus in Italy: incidence and trends over the period 1997-1999R Fontana
Department of Pathology, University of Verona, Italy
Eur J Clin Microbiol Infect Dis 20:854-63. 2001..n=870), Escherichia coli (n=684), Enterobacter cloacae (n=342), Enterobacter aerogenes (n=187) and Serratia marcescens (n=135) as well as the MICs of 11 antibiotics against isolates of Staphylococcus aureus (n=1,606)...
- Analysis of polar lipids from some representative enterobacteria, Plesiomonas and Acinetobacter by fast atom bombardment-mass spectrometryH S Aluyi
Department of Cell and Structural Biology, University of Manchester Dental School, UK
J Appl Bacteriol 73:426-32. 1992..Morganella morganii, Plesiomonas shigelloides, Proteus mirabilis (3 strains), Serratia liquefaciens and Serratia marcescens. Negative-ion spectra provide data for twenty-seven major carboxylate anions (m/z 209-325) and for thirty-..
- Use of microdilution panels with and without beta-lactamase inhibitors as a phenotypic test for beta-lactamase production among Escherichia coli, Klebsiella spp., Enterobacter spp., Citrobacter freundii, and Serratia marcescensK S Thomson
Center for Research in Anti Infectives and Biotechnology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
Antimicrob Agents Chemother 43:1393-400. 1999..pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, and Serratia marcescens possessing well-characterized beta-lactamases...
- Antibacterial activity of BMS-180680, a new catechol-containing monobactamJ Fung-Tomc
Department of Microbiology, Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA Joan
Antimicrob Agents Chemother 41:1010-6. 1997..5 microg/ml for Escherichia coli, Klebsiella spp., Citrobacter diversus, Enterobacter aerogenes, Serratia marcescens, Proteus spp., and Providencia spp...
- Bacterial lipopolysaccharides variably modulate in vitro biofilm formation of Candida speciesH M H N Bandara
Oral Biosciences, Faculty of Dentistry, University of Hong Kong, 5 F Prince Philip Dental Hospital, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR
J Med Microbiol 59:1225-34. 2010..The effect of the LPS of Pseudomonas aeruginosa, Klebsiella pneumoniae, Serratia marcescens and Salmonella typhimurium on six different species of Candida, comprising Candida albicans ATCC 90028, ..
- Natural antibiotic susceptibility of strains of Serratia marcescens and the S. liquefaciens complex: S. liquefaciens sensu stricto, S. proteamaculans and S. grimesiiI Stock
Institut fur Medizinische Mikrobiologie und Immunologie, Pharmazeutische Mikrobiologie, Universitat Bonn, Meckenheimer Allee 168, D 53115 Bonn, Germany
Int J Antimicrob Agents 22:35-47. 2003The natural susceptibility of 77 strains of Serratia marcescens and 41 strains of the S. liquefaciens complex (S. liquefaciens sensu stricto (n=21), S. grimesii (n=10), S...
- Relationships between antimicrobial use and antimicrobial resistance in Gram-negative bacteria causing nosocomial infections from 1991-2003 at a university hospital in TaiwanPo Ren Hsueh
Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, 7, Chung Shan South Road, Taipei, Taiwan
Int J Antimicrob Agents 26:463-72. 2005..Disk susceptibility data of Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Serratia marcescens, Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp...
- [Studies on respiratory infections in primary care clinic (IV). Antibiotic sensitivity of bacteria isolated from patients with respiratory infections visiting 21 private clinics in the Tohoku District of Japan]A Watanabe
Department of Internal Medicine, Tohoku University
Kansenshogaku Zasshi 64:1220-31. 1990..of Escherichia coli, 66 strains of Klebsiella pneumoniae, 26 strains of Enterobacter cloacae, 20 strains of Serratia marcescens, 12 strains of Pseudomonas aeruginosa and 42 strains of Acinetobacter calcoaceticus, isolated from the ..
- The in-vitro antimicrobial activity of some medicinal plants against beta-lactam-resistant bacteriaJoseph Gangoue-Pieboji
Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plant Studies, Yaounde, Cameroon
J Infect Dev Ctries 3:671-80. 2009..In effort to identify novel bacterial agents, this study was initiated to evaluate the antimicrobial properties of 17 crude extracts from 12 medicinal plants against beta-lactam-resistant bacteria...
- Prevalence and diversity of qnr alleles in AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii and Serratia marcescens: a multicentre study from KoreaYeon Joon Park
Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, 505 Banpo Dong, Seocho Ku, Seoul 137 701, Korea
J Antimicrob Chemother 60:868-71. 2007..To investigate the prevalence of qnr determinants, their influence on quinolone susceptibility and their association with other plasmid-mediated genes in AmpC-producing Enterobacteriaceae without any selection criteria...
- [Clinical laboratory approach for estimating the effective administrative dose of latamoxef. Significance of a 4-category system interpretation of the latamoxef disc susceptibility test]T Uete
Department of Clinical Investigation, Kitano Hospital
Jpn J Antibiot 40:1906-16. 1987..56 micrograms/ml. LMOX was less active against Serratia marcescens, inhibiting about 43% of strains at a level of 6.25 micrograms/ml...
- Nucleotide sequence of the Serratia marcescens threonine operon and analysis of the threonine operon mutations which alter feedback inhibition of both aspartokinase I and homoserine dehydrogenase IK Omori
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co, Ltd, Osaka, Japan
J Bacteriol 175:785-94. 1993The nucleotide sequence of the Serratia marcescens threonine operon (thrA1A2BC) was determined...
- Extended-spectrum beta-lactamase-producing Enterobacteriaceae in community and private health care centersCorinne Arpin
Laboratoire de Microbiologie, Universite de Bordeaux 2, 33076 Bordeaux Cedex, France
Antimicrob Agents Chemother 47:3506-14. 2003..pneumoniae isolates; 6 Escherichia coli isolates; 3 Proteus mirabilis isolates; and 1 isolate each of Serratia marcescens, Morganella morganii, and Providencia stuartii...
- Evaluation of Phoenix Automated Microbiology System for detecting extended-spectrum beta-lactamases among chromosomal AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, and Serratia marcescensYeon Joon Park
Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, 505 Banpo Dong, Seocho Ku, Seoul 137 701, Korea
Ann Clin Lab Sci 37:75-8. 2007..among chromosomal AmpC-producing Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, and Serratia marcescens. The study was conducted on 72 non-repetitive ESBL producers (33 E. cloacae, 13 E. aerogenes, 14 C...
- Serratia type pore forming toxinsR Hertle
Laboratory of Molecular Biology, Bethesda, MD, USA
Curr Protein Pept Sci 1:75-89. 2000The Serratia marcescens hemolysin represents a new type of hemolysin and has been studied in great molecular detail with regard to structure, activation and secretion. It has nothing in common with the pore forming toxins of E...
- Spontaneous bacterial peritonitis causing Serratia marcescens and Proteus mirabilis ventriculoperitoneal shunt infection. Case reportLuis M Tumialan
Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosurg 105:320-4. 2006..Cerebrospinal fluid (CSF) cultures grew Serratia marcescens and Proteus mirabilis...
- Production, characterization, cloning and sequence analysis of a monofunctional catalase from Serratia marcescens SYBC08Hua Wei Zeng
The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China
J Basic Microbiol 51:205-14. 2011A monofunctional catalase from Serratia marcescens SYBC08 produced by liquid state fermentation in 7 liter fermenter was isolated and purified by ammonium sulfate precipitation (ASP), ion exchange chromatography (IEC), and gel filtration ..
- Serratia marcescens infection associated with early abortion in cows and buffaloesA M Das
Department of Bacteriology, Bombay Veterinary College, Parel, India
Epidemiol Infect 101:143-9. 1988b>Serratia marcescens was isolated in pure culture from cases of septic abortion in 4 cows on one farm and 10 buffaloes on two other farms...
- Molecular epidemiology of ceftazidime resistant Enterobacteriaceae from patients on a paediatric oncology wardL C Hibbert-Rogers
Department of Microbiology, University of Leeds, UK
J Antimicrob Chemother 36:65-82. 1995..and 1 Serratia marcescens. Clinical isolates were resistant to penicillins and to ceftazidime...
- Convenient test using a combination of chelating agents for detection of metallo-beta-lactamases in the clinical laboratorySoo Young Kim
Center for Research in Anti Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
J Clin Microbiol 45:2798-801. 2007..Sixteen isolates (4 Acinetobacter baumannii isolates, 6 Pseudomonas aeruginosa isolates, 1 Serratia marcescens isolate, 1 Aeromonas hydrophila isolate, 1 Aeromonas veronii isolate, 2 Chryseobacterium meningosepticum ..
- Isolation and sequence analysis of rpoH genes encoding sigma 32 homologs from gram negative bacteria: conserved mRNA and protein segments for heat shock regulationK Nakahigashi
HSP Research Institute, Kyoto Research Park, Japan
Nucleic Acids Res 23:4383-90. 1995..sequenced from five gram negative proteobacteria (gamma or alpha subgroup): Enterobacter cloacae (gamma), Serratia marcescens (gamma), Proteus mirabilis (gamma), Agrobacterium tumefaciens (alpha) and Zymomonas mobilis (alpha)...
- A novel class A extended-spectrum beta-lactamase (BES-1) in Serratia marcescens isolated in BrazilR Bonnet
Laboratoire de Bacteriologie, Faculte de Medecine, 63001 Clermont Ferrand cedex, France
Antimicrob Agents Chemother 44:3061-8. 2000b>Serratia marcescens Rio-5, one of 18 extended-spectrum beta-lactamase (ESBL)-producing strains isolated in several hospitals in Rio de Janeiro (Brazil) in 1996 and 1997, exhibited a high level of resistance to aztreonam (MIC, 512 ..
- Eggshell factors influencing eggshell penetration and whole egg contamination by different bacteria, including Salmonella enteritidisK De Reu
Department of Animal Product Quality and Transformation Technology, Agricultural Research Centre Ghent, Ministry of the Flemish Community, Brusselsesteenweg 370, 9090 Melle, Belgium
Int J Food Microbiol 112:253-60. 2006..b>Serratia marcescens, Carnobacterium sp., Pseudomonas sp. and Salmonella enteritidis, recovered from egg contents, were studied...
- In vitro activity of Ro 23-9424, a dual-action cephalosporin, compared with activities of other antibioticsJ W Gu
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032
Antimicrob Agents Chemother 34:189-95. 1990..It inhibited the majority of members of the family Enterobacteriaceae, except for some Serratia marcescens, Citrobacter freundii, and Enterobacter cloacae strains, at less than or equal to 0...
- [A methodological study on testing and evaluating of filtration efficiency of canister against microbial aerosol]Zhan bo Wen
State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, National Research Center for Bio protection Equipment, Beijing 100071, China
Zhonghua Yu Fang Yi Xue Za Zhi 43:686-9. 2009..To establish a testing and evaluating method for filtration efficiency of the canister against microbial aerosol...
- Evaluation of a new generation of plastic culture bottles with an automated microbial detection system for nine common contaminating organisms found in PLT componentsM E Brecher
Transfusion Medicine Service, CB 7600, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA
Transfusion 44:359-63. 2004..The recovery of nine organisms seeded into PLTs with new plastic culture bottles was studied in comparison to the current glass bottles. The use of plastic instead of glass would be expected to reduce the risk of injury...
- Temporal association of entomopathogenic nematodes (Rhabditida: Steinernematidae and Heterorhabditidae) and bacteriaDawn H Gouge
University of Arizona, MAC, 37860 West Smith Enke Road, Phoenix, AZ 85239, USA
J Invertebr Pathol 91:147-57. 2006..Pseudomonas fluorescens type C, Serratia marcescens, Citrobacter freundii, and Serratia proteomaculans...
- Evaluation of an automated culture system for detecting bacterial contamination of platelets: an analysis with 15 contaminating organismsM E Brecher
University of North Carolina Hospitals, Chapel Hill, North Carolina 27514, USA
Transfusion 41:477-82. 2001..Approximately 1 in 2000 platelet components are bacterially contaminated. The time to detection of 15 seeded organisms in platelets recovered from an automated culture system was studied...
- A multistate outbreak of Serratia marcescens bloodstream infection associated with contaminated intravenous magnesium sulfate from a compounding pharmacyRebecca H Sunenshine
Centers for Disease Control and Prevention, Arizona Dept of Health Services, 150 N 18th Ave, Ste 150, Phoenix, AZ 85007, USA
Clin Infect Dis 45:527-33. 2007..In 2005, the Centers for Disease Control and Prevention received reports of cases of Serratia marcescens bloodstream infection occurring in patients who underwent cardiac surgical procedures in Los Angeles, ..
- Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospitalJia Chang Cai
2nd Affiliated Hospital of Zhejiang University, 88 Jiefang Rd, Hangzhou, China 310009
Antimicrob Agents Chemother 52:2014-8. 2008Twenty-one Serratia marcescens, ten Klebsiella pneumoniae, and one Escherichia coli isolate with carbapenem resistance or reduced carbapenem susceptibility were recovered from intensive care units (ICUs) in our hospital...
- Significant improvement of Serratia marcescens lipase fermentation, by optimizing medium, induction, and oxygen supplyZhang De Long
Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, People s Republic of China
Appl Biochem Biotechnol 142:148-57. 2007Production of an extracellular lipase from Serratia marcescens ECU1010, which is an industrially important biocatalyst for the stereospecific synthesis of Diltiazem precursor, was carefully optimized in both shake flasks and a fermenter, ..
- Utilization of mucus from the coral Acropora palmata by the pathogen Serratia marcescens and by environmental and coral commensal bacteriaCory J Krediet
University of Florida, Gainesville, 32611, USA
Appl Environ Microbiol 75:3851-8. 2009..commensal bacteria ("Photobacterium mandapamensis" and Halomonas meridiana) and by opportunistic Serratia marcescens pathogens. S...
- Purification and partial characterization of psychrotrophic Serratia marcescens lipaseAdham M Abdou
Department of Food Hygiene, Faculty of Veterinary Medicine, Benha University, Moshtohor 13736 Kaliobyia, Egypt
J Dairy Sci 86:127-32. 2003b>Serratia marcescens isolated from raw milk was found to produce extracellular lipase. The growth of this organism could contribute to flavor defects in milk and dairy products...
- Characterization of an exochitinase from Epiphyas postvittana nucleopolyhedrovirus (family Baculoviridae)Vivienne L Young
Department of Microbiology and Immunology, School of Medical Sciences, University of Otago, PO Box 56, Dunedin, New Zealand
J Gen Virol 86:3253-61. 2005..Homology modelling of the chitinase of Epiphyas postvittana nucleopolyhedrovirus (EppoNPV) against Serratia marcescens chitinase A indicated that the enzyme possesses an N-terminal polycystic kidney 1 (PKD1) domain for chitin-..
- Pathogenic capacity of proteases from Serratia marcescens and Pseudomonas aeruginosa and their suppression by chicken egg white ovomacroglobulinA Molla
Department of Microbiology, Kumamoto University Medical School, Japan
Infect Immun 55:2509-17. 1987The pathogenicities of three proteases from Serratia marcescens, two proteases from Pseudomonas aeruginosa, and one thermolysin from Bacillus stearothermophilus were examined...
- Kinetic analysis of growth rate, ATP, and pigmentation suggests an energy-spilling function for the pigment prodigiosin of Serratia marcescensPryce L Haddix
Department of Biology, Auburn University Montgomery, P O Box 244023, Montgomery, AL 36124 4023, USA
J Bacteriol 190:7453-63. 2008b>Serratia marcescens is a gram-negative environmental bacterium and opportunistic pathogen. S. marcescens expresses prodigiosin, a bright red and cell-associated pigment which has no known biological function for producing cells...
- Infectious crystalline keratopathy caused by Serratia marcescensChing Long Chen
Department of Ophthalmology, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Cornea 26:1011-3. 2007..To report the case of a 70-year-old woman with Serratia infectious crystalline keratopathy...
- [Isolation and characterization of Serratia marcescens phage]Long Yu
State Research Center for Bio protective Equipment and Engineering Technology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China
Wei Sheng Wu Xue Bao 48:498-502. 2008To isolate the bacteriophage of Serratia marcescens (8039) from sewage, and to study on its biological characteristics.
- In vitro and in vivo antibacterial activities of E-4868, a new fluoroquinolone with a 7-azetidin ring substituentJ Guinea
Department of Sanitary Microbiology and Parasitology, Faculty of Pharmacy, University of Barcelona, Spain
Antimicrob Agents Chemother 37:868-74. 1993..03 and 1 microgram/ml were observed, with the exception of those against Serratia marcescens and Providencia spp., and a MIC90 of 2 micrograms/ml against Pseudomonas aeruginosa was obtained...
- Activity domains of the TonB proteinI Traub
Mikrobiologie II, Universitat Tubingen, Germany
Mol Microbiol 8:409-23. 1993..Differences in the activities of the Escherichia coli and the Serratia marcescens TonB proteins were used to identify TonB functional domains. In E...
- Ceftazidime combined with mecillinam: serum bactericidal titres compared with in-vitro synergy against gram-negative bacilliP Van der Auwera
Service de Medecine, Institut Jules Bordet, Universite Libre de Bruxelles, Belgium
J Antimicrob Chemother 21:745-53. 1988..Ten strains each of Klebsiella pneumoniae, Serratia marcescens, Citrobacter freundii, Salmonella spp. and Yersinia spp. and nine strains each of Acinetobacter spp...
- Illness-induced anorexia and its possible function in the caterpillar, Manduca sextaShelley A Adamo
Department of Psychology and Neuroscience, Dalhousie University, Halifax, NS, Canada
Brain Behav Immun 21:292-300. 2007..Injecting Manduca sexta larvae (caterpillars) with live bacteria (Serratia marcescens), heat-killed bacteria or bacterial lipopolysaccharides resulted in a decline in feeding, demonstrating ..
- A novel medium for the enhanced cell growth and production of prodigiosin from Serratia marcescens isolated from soilAnuradha V Giri
Centre for Biotechnology, Anna University, Chennai 600025, India
BMC Microbiol 4:11. 2004Prodigiosin produced by Serratia marcescens is a promising drug owing to its reported characteristics of having antifungal, immunosuppressive and antiproliferative activity...
- Production, purification and characterization of a 50-kDa extracellular metalloprotease from Serratia marcescensP R Salamone
Department of Molecular Biology and Microbiology, University of Central Florida, Orlando 32816 2360, USA
Appl Microbiol Biotechnol 48:317-24. 1997The extracellular metalloprotease (SMP 6.1) produced by a soil isolate of Serratia marcescens NRRL B-23112 was purified and characterized. SMP 6...
- (123)I-Labeled chitinase as specific radioligand for in vivo detection of fungal infections in miceRien Siaens
Laboratory of Radiopharmacy, Gent University, Gent, Belgium
J Nucl Med 45:1209-16. 2004..ChiB_E144Q (ChiB = chitinase B) from Serratia marcescens was labeled with (123)I, and in vitro and in vivo studies were assessed.
- Characterization of the mineral phosphate solubilizing activity of Serratia marcescens CTM 50650 isolated from the phosphate mine of GafsaMounira Ben Farhat
Laboratoire d Enzymes et de Metabolites des Procaryotes LEMP, Centre de Biotechnologie de Sfax, Route de Sidi Mansour Km 6, BP 1177, 3018 Sfax, Tunisia
Arch Microbiol 191:815-24. 2009The mineral phosphate solubilizing (MPS) ability of a Serratia marcescens strain, namely CTM 50650, isolated from the phosphate mine of Gafsa, was characterized on a chemically defined medium (NBRIP broth)...
- Validation of BacT/ALERT plastic culture bottles for use in testing of whole-blood-derived leukoreduced platelet-rich-plasma-derived plateletsM E Brecher
University of North Carolina, Chapel Hill, North Carolina 27514, USA
Transfusion 44:1174-8. 2004..This study validated the BacT/ALERT for use in testing pooled PRP-derived PLTs with nine contaminating organisms...
- Prevalence and characteristics of aac(6')-Ib-cr in AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens: a multicenter study from KoreaSoo Young Kim
Department of Laboratory Medicine, The Catholic University of Korea, St Vincent s Hospital, Paldal Gu, Suwon, South Korea
Diagn Microbiol Infect Dis 63:314-8. 2009..A total of 479 clinical isolates of Enterobacter cloacae (179), Citrobacter freundii (134), and Serratia marcescens (166) from 12 laboratories between March and July 2005 were examined...
- Occurrence of extended-spectrum beta-lactamases among chromosomal AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens in Korea and investigation of screening criteriaYeon Joon Park
Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, Seoul 137 040, Korea
Diagn Microbiol Infect Dis 51:265-9. 2005..beta-lactamases (ESBLs) among AmpC-producing Enterobacter cloacae, Citrobacter freundii, and Serratia marcescens. The 413 isolates (158 E. cloacae, 126 C. freundii, and 129 S...
- The importance of chitobiase and N-acetylglucosamine (GlcNAc) uptake in N,N'-diacetylchitobiose [(GlcNAc)2] utilization by Serratia marcescens 2,170Tadayuki Toratani
Department of Applied Biological Chemistry, Faculty of Agriculture, Niigata University, 8050 Ikarashi 2, Niigata 950 2181, Japan
Microbiology 154:1326-32. 2008..GlcNAc)(2)] is the main degradation product from chitin by the action of chitinases of Serratia marcescens 2170...
- Hyperproduction of inhibitor-susceptible TEM beta-lactamase is responsible for resistance of Serratia marcescens to beta-lactam-beta-lactamase inhibitor combinationsWei Hua Zhao
Department of Microbiology and Immunology, Showa University Hospital, Showa University School of Medicine, Tokyo, Japan
Chemotherapy 54:31-7. 2008Some clinical isolates of Serratia marcescens showed high-level resistance to expanded-spectrum cephalosporins alone and in combination with beta-lactamase inhibitor, but the beta-lactamase extracted from these strains was sensitive to ..
- Re-evaluation of the serotypes of Serratia marcescens and separation into two schemes based on lipopolysaccharide (O) and capsular polysaccharide (K) antigensH M Aucken
Laboratory of Hospital Infection, Central Public Health Laboratory, London, UK
Microbiology 144:639-53. 1998Chemical and serological analysis has revealed that many of the 29 O serotype reference strains of Serratia marcescens contain both neutral and acidic polysaccharides which correspond to LPS O antigens and capsular K antigens, ..
- Novel tetracycline resistance determinant isolated from an environmental strain of Serratia marcescensStuart A Thompson
Department of Biochemistry and Molecular Biology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 2100, USA
Appl Environ Microbiol 73:2199-206. 2007Resistances to tetracycline and mercury were identified in an environmental strain of Serratia marcescens isolated from a stream highly contaminated with heavy metals...
- Case-control analysis of endemic Serratia marcescens bacteremia in a neonatal intensive care unitMatthew J Bizzarro
Divisions of Perinatal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
Arch Dis Child Fetal Neonatal Ed 92:F120-6. 2007b>Serratia marcescens is an opportunistic gram-negative rod which typically infects compromised hosts.
- Multistate outbreak of Serratia marcescens bloodstream infections caused by contamination of prefilled heparin and isotonic sodium chloride solution syringesDavid Blossom
Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Arch Intern Med 169:1705-11. 2009To investigate clusters of Serratia marcescens (SM) bloodstream infections (BSIs) at health care facilities in several states and determine whether contaminated prefilled heparin and isotonic sodium chloride solution (hereinafter, saline)..
- Effects of temperature, nutrients, organic matter and coral mucus on the survival of the coral pathogen, Serratia marcescens PDL100Erin E Looney
Department of Environmental Health Science, The University of Georgia, Athens, GA, USA
Environ Microbiol 12:2479-85. 2010b>Serratia marcescens is an enteric bacterium that causes white pox disease in elkhorn coral, Acropora palmata; however, it remains unclear if the pathogenic strain has adapted to seawater or if it requires a host or reservoir for survival...
- Serratia marcescens internalization and replication in human bladder epithelial cellsRalf Hertle
Microbiology Membranphysiology, University of Tubingen, Germany
BMC Infect Dis 4:16. 2004b>Serratia marcescens, a frequent agent of catheterization-associated bacteriuria, strongly adheres to human bladder epithelial cells in culture...
- Effect of chemical and physical parameters on the production of L-asparaginase from a newly isolated Serratia marcescens SK-07A Agarwal
Biochemical Engineering Laboratory, Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam, India
Lett Appl Microbiol 52:307-13. 2011..of carbon and nitrogen sources of the medium in shake flask experiments and evaluate the effect of pH and dissolved oxygen (DO) on the production of L-asparaginase from a newly isolated Serratia marcescens SK-07 in a batch bioreactor.
- Outbreak of Serratia marcescens infections following injection of betamethasone compounded at a community pharmacyRachel Civen
Los Angles County Department of Health Services, Acute Communicable Disease Control Program, Los Angeles, CA 90012, USA
Clin Infect Dis 43:831-7. 2006In June 2001, following the report of 4 patients with Serratia marcescens meningitis who received epidural injections of betamethasone compounded at a community pharmacy, we initiated an outbreak investigation.
- Morphological and genetic analysis of three bacteriophages of Serratia marcescens isolated from environmental waterKenshi Matsushita
Department of Pediatrics, Kochi Medical School, Nankoku, Kochi, Japan
FEMS Microbiol Lett 291:201-8. 2009Increases in multidrug-resistant strains of Serratia marcescens are of great concern in pediatrics, especially in neonatal intensive care units...
- Zymar (Gatifloxacin 0.3%) shows excellent Gram-negative activity against Serratia marcescens and Pseudomonas aeruginosa in a New Zealand White rabbit keratitis modelFrancis S Mah
Charles T Campbell Ophthalmic Microbiology Laboratory, UPMC Eye Center, Ophthalmology and Visual Sciences Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Cornea 26:585-8. 2007..3%), and fortified tobramycin (14 mg/mL) in the treatment of experimental Gram-negative bacterial infections of Serratia marcescens (SM) and Pseudomonas aeruginosa (PA) in the New Zealand White (NZW) rabbit keratitis model.
- Presence of a group II intron in a multiresistant Serratia marcescens strain that harbors three integrons and a novel gene fusionDaniela Centron
Departement de Biochimie et de Microbiologie, Faculte des sciences et de genie, Universite Laval, Sainte Foy, Quebec, Canada G1K 7P4
Antimicrob Agents Chemother 46:1402-9. 2002..of integrons in the dissemination of antibiotic resistance in a recent multiresistant clinical isolate, Serratia marcescens SCH88050909 (SCH909). This isolate harbors three integrons, all on a 60-kb conjugative plasmid...
- SME-type carbapenem-hydrolyzing class A beta-lactamases from geographically diverse Serratia marcescens strainsA M Queenan
The R W Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869, USA
Antimicrob Agents Chemother 44:3035-9. 2000Three sets of carbapenem-resistant Serratia marcescens isolates have been identified in the United States: 1 isolate in Minnesota in 1985 (before approval of carbapenems for clinical use), 5 isolates in Los Angeles (University of ..
- Serratia marcescens endophthalmitis associated with intravitreal injections of bevacizumabS H Lee
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea
Eye (Lond) 24:226-32. 2010To report two cases of Serratia marcescens endophthalmitis related to presumed aliquot drug contamination, and to determine the incidence of acute endophthalmitis after intravitreal injection of bevacizumab.
- Detection of cefotaxime-resistant CTX-M-3 in clinical isolates of Serratia marcescensMei Fen Tsou
Department of Clinical Laboratory, China Medical University Hospital, Taichung, Taiwan, Republic of China
Folia Microbiol (Praha) 49:452-6. 2004Strains of Serratia marcescens (isolated in a hospital during April and August 2000) resistant to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, streptomycin, tetracycline, and gentamicin were characterized...
- A simultaneous outbreak of Serratia marcescens and Klebsiella pneumoniae in a neonatal intensive care unitC Casolari
Unit of Microbiology and Virology, Policlinico of Modena, Italy
J Hosp Infect 61:312-20. 2005We describe two concurrent outbreaks of Serratia marcescens and Klebsiella pneumoniae in a neonatal intensive care unit (NICU). Over a 16-month period, a total of 27 infants were either colonized (N=14) or infected (N=13)...
- Genomic comparison of plant pathogenic and nonpathogenic Serratia marcescens strains by suppressive subtractive hybridizationQ Zhang
Department of Entomology and Plant Pathology, 127 Noble Research Center, Oklahoma State University, Stillwater, OK 74078, USA
Appl Environ Microbiol 71:7716-23. 2005Cucurbit yellow vine disease (CYVD) is caused by disease-associated Serratia marcescens strains that have phenotypes significantly different from those of nonphytopathogenic strains...
- Uptake of N,N'-diacetylchitobiose [(GlcNAc)2] via the phosphotransferase system is essential for chitinase production by Serratia marcescens 2170Taku Uchiyama
Department of Biosystem Science, Graduate School of Science and Technology, Niigata University, Niigata 950 2181, Japan
J Bacteriol 185:1776-82. 2003The chiR gene of Serratia marcescens 2170, encoding a LysR-type transcriptional activator, was identified previously as an essential factor for expression of chitinases and a chitin-binding protein, CBP21...
- Analyses of ampC gene expression in Serratia marcescens reveal new regulatory propertiesSteven D Mahlen
Center for Research in Anti Infectives and Biotechnology, Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA
J Antimicrob Chemother 51:791-802. 2003b>Serratia marcescens encodes an inducible, chromosomal beta-lactamase, ampC. Studies addressing the regulation of inducible ampC genes have focused primarily on Enterobacter cloacae and Citrobacter freundii...
- [Control measures against Serratia marcescens colonization at the neonatal intensive care unit of UOEH hospital]Takako Ikeno
Infection Control Group, University Hospital, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
J UOEH 25:89-101. 2003..neonatal intensive care unit (NICU) patients were found to be colonized with pigment-producing strains of Serratia marcescens. The UOEH Infection Control Group (ICG) committee investigated the source of this epidemic and carried out ..
- The LuxR family protein SpnR functions as a negative regulator of N-acylhomoserine lactone-dependent quorum sensing in Serratia marcescensYu Tze Horng
School and Graduate Institute of Medical Technology, College of Medicine, National Taiwan University, Taipei, ROC
Mol Microbiol 45:1655-71. 2002b>Serratia marcescens SS-1 produces at least four N-acylhomoserine lactones (AHLs) which were identified using high-resolution mass spectrometry and chemical synthesis, as N-(3-oxohexanoyl) homo-serine lactone (3-oxo-C6-HSL), N-hexanoyl- (..
- The outbreak of Serratia marcescens bacteremia in a pediatric ward, Siriraj Hospital 1997Kulkanya Chokephaibulkit
Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
J Med Assoc Thai 85:S674-81. 2002Between October 20 and November 11, 1997, Serratia marcescens bacteremia was identified in 8 patients in a pediatric ward at Siriraj Hospital. The organism was isolated from 17 blood and 3 bone marrow specimens...
- Survey of CTX-M-3 extended-spectrum beta-lactamase (ESBL) among cefotaxime-resistant Serratia marcescens at a medical center in middle TaiwanLii Tzu Wu
Department of Microbiology, Institute of Medical Science, China Medical University, Taichung City, Taiwan
Diagn Microbiol Infect Dis 49:125-9. 2004Thirty-four clinical isolates of Serratia marcescens nonsusceptible to cefotaxime were collected from a medical center in middle Taiwan...
- Serratia marcescens in a neonatal intensive care unit: two long-term multiclone outbreaks in a 10-year observational studyChiara Casolari
Department to Integrated Activity of Laboratory Medicine, Modena, Italy
New Microbiol 36:373-83. 2013We investigated two consecutive Serratia marcescens (S. marcescens) outbreaks which occurred in a neonatal intensive care unit (NICU) of a tertiary level hospital in North Italy in a period of 10 years (January 2003-December 2012)...
- Haemophore-mediated signal transduction across the bacterial cell envelope in Serratia marcescens: the inducer and the transported substrate are different moleculesMaria Silvia Rossi
Groupe de Génétique des Biofilms Institut Pasteur CNRS URA 2172, 25 rue du Dr Roux, Paris Cedex 15, France
Mol Microbiol 48:1467-80. 2003..Here, we report a study of the regulation of the Serratia marcescens has operon which is involved in haemophore-dependent haem acquisition...
- Endo/exo mechanism and processivity of family 18 chitinases produced by Serratia marcescensSvein J Horn
Department of Chemistry, Biotechnology and Food Science, The Norwegian University of Life Sciences, As, Norway
FEBS J 273:491-503. 2006We present a comparative study of ChiA, ChiB, and ChiC, the three family 18 chitinases produced by Serratia marcescens. All three enzymes eventually converted chitin to N-acetylglucosamine dimers (GlcNAc2) and a minor fraction of ..
- Cloning, sequencing, and characterization of the SdeAB multidrug efflux pump of Serratia marcescensAyush Kumar
Department of Microbiology, University of Manitoba, Winnipeg, MB R3T 2N2, Manitoba, Canada
Antimicrob Agents Chemother 49:1495-501. 2005b>Serratia marcescens is an important nosocomial agent known for causing various infections in immunocompromised individuals. Resistance of this organism to a broad spectrum of antibiotics makes the treatment of infections very difficult...
- Prevalence of decreased susceptibility to carbapenems among Serratia marcescens, Enterobacter cloacae, and Citrobacter freundii and investigation of carbapenemasesHae Kyung Lee
Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Kangnam St Mary s Hospital, Seoul 137 040, Republic of Korea
Diagn Microbiol Infect Dis 52:331-6. 2005Between March and July 2002, total of 612 clinical isolates of Serratia marcescens, Enterobacter cloacae, and Citrobacter freundii (201 S. marcescens, 228 E. cloacae, and 183 C...
- [Effect of subinhibitory levels of aminoglycosides and fluoroquinolines on hydrophobicity and motility of Serratia marcescens]V Majtan
Ustav preventívnej a klinickej medicíny, Bratislava
Epidemiol Mikrobiol Imunol 50:26-30. 2001..gentamicin, netilmicin, tobramycin) on the surface hydrophobicity and motility of the clinical isolate of Serratia marcescens. The hydrophobicity was evaluated by methods of adherence to the hydrocarbon xylene (BATH) in a salt-..
- Complete sequence of broad-host-range plasmid pRIO-5 harboring the extended-spectrum-β-lactamase gene blaBES₋₁Rémy A Bonnin
Service de Bacteriologie Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculté de Médecine et Université Paris Sud, K Bicêtre, France
Antimicrob Agents Chemother 56:1116-9. 2012Broad-host-range plasmid pRIO-5, harboring the extended-spectrum β-lactamase bla(BES-1) gene in Serratia marcescens, was fully sequenced...
- The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycinAmy J Gerc
Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, United Kingdom
PLoS ONE 7:e44673. 2012..We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the growth of Bacillis subtilis and Staphyloccocus ..
- The PhoP/PhoQ system and its role in Serratia marcescens pathogenesisJulieta Barchiesi
Instituto de Biologia Molecular y Celular de Rosario IBR CONICET, Departamento de Microbiologia, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Rosario, Argentina
J Bacteriol 194:2949-61. 2012b>Serratia marcescens is able to invade, persist, and multiply inside nonphagocytic cells, residing in nonacidic, nondegradative, autophagosome-like vacuoles...
- A Serratia marcescens PigP homolog controls prodigiosin biosynthesis, swarming motility and hemolysis and is regulated by cAMP-CRP and HexSRobert M Q Shanks
Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 8:e57634. 2013..The broad host-range opportunistic pathogen Serratia marcescens produces serratamolide, a small cyclic amino-lipid, that promotes swarming motility and hemolysis...
- Outbreak of a cluster with epidemic behavior due to Serratia marcescens after colistin administration in a hospital settingAndrea Karina Merkier
Instituto de Microbiología y Parasitología Médica, Facultad de Medicina, Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y Tecnológicas IMPaM, UBA CONICET, Buenos Aires, Argentina
J Clin Microbiol 51:2295-302. 2013b>Serratia marcescens causes health care-associated infections with important morbidity and mortality...
- Gene expression analysis of the SdeAB multidrug efflux pump in antibiotic-resistant clinical isolates of Serratia marcescensS D Dalvi
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, MB, Canada
Indian J Med Microbiol 30:302-7. 2012Many isolates of Serratia marcescens, a well-known opportunistic pathogen, can be multidrug resistant. Fluoroquinolones are among the most important groups of antibiotics used for treatment of these organisms...
- Ligand delivery by haem carrier proteins: the binding of Serratia marcescens haemophore to its outer membrane receptor is mediated by two distinct peptide regionsSylvie Létoffé
Unité des Membranes Bactériennes, Institut Pasteur CNRS URA2172 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Mol Microbiol 50:77-88. 2003..The Serratia marcescens haemophore (HasA) is folded into a globular form and tyrosine and histidine are involved in haem ligation...
- Activities of the Serratia marcescens heme receptor HasR and isolated plug and beta-barrel domains: the beta-barrel forms a heme-specific channelSylvie Létoffé
Unité des Membranes Bactériennes, Institut Pasteur, CNRS URA 2172, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Bacteriol 187:4637-45. 2005The Serratia marcescens hemophore-specific outer membrane receptor HasR is a member of the TonB-dependent family of autoregulated receptors. It can transport either heme itself or heme bound to the hemophore HasA...
- Serratamolide is a hemolytic factor produced by Serratia marcescensRobert M Q Shanks
Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
PLoS ONE 7:e36398. 2012b>Serratia marcescens is a common contaminant of contact lens cases and lenses. Hemolytic factors of S. marcescens contribute to the virulence of this opportunistic bacterial pathogen...
- Biosynthesis of bismuth nanoparticles using Serratia marcescens isolated from the Caspian Sea and their characterisationP Nazari
Tehran University of Medical Sciences, Department of Pharmaceutical Biotechnology and Biotechnology Research Centre, Tehran, Iran
IET Nanobiotechnol 6:58-62. 2012..This isolate was identified as non-pigmented Serratia marcescens using conventional identification assays and the 16s rDNA fragment amplification method and used to prepare ..
- Serratia marcescens quinoprotein glucose dehydrogenase activity mediates medium acidification and inhibition of prodigiosin production by glucoseJames E Fender
Charles T Campbell Laboratory of Ophthalmic Microbiology, Department of Ophthalmology, University of Pittsburgh Eye Center, Pittsburgh, Pennsylvania, USA
Appl Environ Microbiol 78:6225-35. 2012b>Serratia marcescens is a model organism for the study of secondary metabolites...
- [Comparative antibacterial activity of fleroxacin: selection frequencies and outer membrane proteins of resistant mutants]W Cullmann
Institut für Hygiene und Mikrobiologie der Ruhr Universität Bochum
Immun Infekt 16:152-8. 1988..Selection frequencies for resistant clones were evaluated for clinical E. coli and Serratia marcescens isolates and the quinolones. With respect to clinical E...
- A replication region of the IncHI plasmid, R27, is highly homologous with the RepFIA replicon of FD Saul
Department of Cell Biology, University of Auckland, New Zealand
Mol Microbiol 2:219-25. 1988..The results are consistent with the observed incompatibility behaviour of R27, and have a bearing on the specificity of interaction of E protein with its DNA-binding sites...
- Role of serine 352 in the allosteric response of Serratia marcescens aspartokinase I-homoserine dehydrogenase I analyzed by using site-directed mutagenesisK Omori
Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co, Ltd, Osaka, Japan
J Bacteriol 175:959-65. 1993Aspartokinase I and homoserine dehydrogenase I (AKI-HDI) from Serratia marcescens Sr41 are encoded by the thrA gene as a single polypeptide chain...
- Plasmid-mediated formaldehyde resistance in Serratia marcescens and Escherichia coli: alterations in the cell surfaceP M Kaulfers
, , Hamburg, Federal Republic of Germany
Zentralbl Bakteriol Mikrobiol Hyg A 266:239-48. 1987The plasmid-mediated formaldehyde resistance of Serratia marcescens and Escherichia coli was examined. For that purpose the outer membranes of isogenic strains (with and without resistance plasmid) were compared...
- Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescensHideaki Maseda
Institute of Technology and Science, The University of Tokushima Graduate School, Tokushima, Japan
Antimicrob Agents Chemother 53:5230-5. 2009b>Serratia marcescens is an important opportunistic pathogen in hospitals, where quaternary ammonium compounds are often used for disinfection...
- Insights into the role of the (alpha+beta) insertion in the TIM-barrel catalytic domain, regarding the stability and the enzymatic activity of chitinase A from Serratia marcescensAthanassios C Zees
National and Kapodistrian University of Athens, Department of Biochemistry and Molecular Biology, Panepistimiopolis Zographou, 15784 Athens, Greece
Biochim Biophys Acta 1794:23-31. 2009Chitinase A (ChiA) from Serratia marcescens is a mesophilic enzyme with high catalytic activity and high stability...
- Isolation and location on the R27 map of two replicons and an incompatibility determinant specific for IncHI1 plasmidsP Gabant
Universite Libre de Bruxelles, Departement de Biologie Moleculaire, Belgium
J Bacteriol 175:7697-701. 1993..In this communication, we present the mapping of these maintenance elements on the R27 genome...
- Extended-spectrum beta-lactamases conferring resistance to monobactams and oxyimino-cephalosporins in clinical isolates of Serratia marcescensF Luzzaro
Clinical Pathology Laboratory, Ospedale di Circolo, Varese, Italy
J Chemother 7:175-8. 1995We studied antibiotic resistance patterns and extended-spectrum beta-lactamases (ES beta Ls) production in Serratia marcescens strains isolated in our hospital during 1993. We examined 210 S. marcescens isolates...
- An outbreak of Serratia marcescens septicaemia in neonatal intensive care unit in Gaza City, PalestineA M Kh Al Jarousha
Laboratory Medicine Department, Al Azhar University, Gaza, Gaza Strip, Palestine
J Hosp Infect 70:119-26. 2008We performed a case-control study of Serratia marcescens incidence in the neonatal intensive care unit of a governmental Gaza Strip hospital from January to December 2005. S...
- Crystal structure of a complex between Serratia marcescens metallo-protease and an inhibitor from Erwinia chrysanthemiU Baumann
Institut für Organische Chemie und Biochemie der Universität, Freiburg, Germany
J Mol Biol 248:653-61. 1995The crystal structure of the complex between the 50 kDa metallo-endoproteinase from Serratia marcescens (SMP), a member of the metzincin superfamily, and an inhibitor from Erwinia chrysanthemi (Inh) was solved by molecular replacement ..
Research Grants13
- Characterization of Hemolysin A from Proteus mirabilisTodd Weaver; Fiscal Year: 2004..for the secretion of large exoproteins, including the Ca2+-independent cytolysins/hemolyins from Serratia marcescens, Edwardsiella tarda, Yersinia pestis and Proteus mirabilis...
- Novel anti-bacterial therapy for gram negative pneumoniaKanneganti Murthy; Fiscal Year: 2001..strategies that target the N-terminal domain of flagellin reduce mortality in LD9O-100 murine models of Serratia marcescens induced acute pneumonia to less than 10 percent...
- ENZYMOLOGY OF ANTIBIOTIC RESISTANCERichard Armstrong; Fiscal Year: 2009..Plasmid encoded versions of FosA and FosX have been found in multi-drug resistant plasmids Serratia marcescens and P. putida...
- HPMB AS A MODEL FOR HEMOLYSIN SECRETION/ACTIVATIONTIMOTHY UPHOFF; Fiscal Year: 1999..Proteins related to HpmA and B have been identified as virulence factors among other species of Proteus, Serratia marcescens and a variety of other gram-negative bacterial pathogens...
- EVOLUTION AND REGULATION OF MERCURIAL RESISTANCE GENESTAPAN MISRA; Fiscal Year: 1992..The regulatory genes from the broad spectrum mercurial resistance operons of the Serratia marcescens plasmid pDU1358 and Staphylococcus aureus plasmid pI258 will be cloned into a hyperexpression vector (pI258)..
- CAMPYLOBACTER FETUS SURFACE LAYER PROTEIN SECRETIONStuart Thompson; Fiscal Year: 2002..coli. They will use deletion and mutational analyses to define the C. fetus SapA C-terminal secretion signal. The ability of the SapA secretion to mediate the transport of normally non-secreted proteins also will be assessed. ..
- Campylobacter jejuni DNA methylation and gene regulationStuart Thompson; Fiscal Year: 2004..Specific Aim 3. Elucidate the upstream factors and signals controlling Cj1461 and Cj0355 expression to reveal the entire regulatory circuit. ..
- Prevention of Healthcare-Associated Drug-Resistant GNRLisa Maragakis; Fiscal Year: 2006..Maragakis with the skills she needs to develop into an independent clinical investigator in epidemiologic research for the prevention of healthcare-associated infections. ..
- Campylobacter jejuni proteins induced at 37CStuart Thompson; Fiscal Year: 2007..jejuni proteins that are induced at 37C.Specific Aim 3. Elucidate the roles of specific 37C-induced proteins in human epithelial cell binding and invasion in vitro, and in colonization in a mouse model. ..
- Susceptibility Testing, Treatment Choices, and Outcomes of MDR-GNB InfectionsLisa Maragakis; Fiscal Year: 2009..This research is designed to better understand how providers use information from various microbiology laboratory testing methods to choose treatments and to identify strategies that lead to the best patient outcomes. ..
- Campylobacter jejuni outer membrane protein vaccineStuart Thompson; Fiscal Year: 2009..Specific Aim 3. We will determine whether immunization of mice with conserved, purified recombinant OMPs protects against subsequent experimental C. jejuni infection. ..


text:
Pelissero: Ready or not, rookie Chris Cook has shot at starting job
Get the 1500 ESPN SportsWire delivered to your inbox daily, and keep up with all the news in Twin Cities Sports
MINNEAPOLIS -- Chris Cook's chance to start for the Minnesota Vikings may be coming more quickly than anyone expected.
Including Cook.
The Vikings' decision to move their top draft pick from left cornerback with the second string to right with the starters in practice this week confirms Cook will have every chance to beat out Lito Sheppard and Asher Allen over the final two preseason games.
This, from a somewhat raw 23-year-old who missed minicamp with a hamstring injury and was relegated to the third string when training camp opened less than a month ago.
"I was very hopeful," Cook said after practice on Thursday of his chances to be in this position.
"I was just being humble and just biding my time, just trying to get on the field anywhere I could. It coming this fast -- I wasn't really expecting it, because I do have a lot of veterans in front of me. I was using this year for a learning experience. (But) hard work pays off, and I'm in a position right now where I get an opportunity to play with the ones."
It took all of three days for Cook to flash in camp. He picked off three passes in one practice and was on the rise from then on, repeatedly using his size (6-foot-2, 212 pounds) and long arms (32½ inches) to beat up and best a depleted receiver corps.
Most striking has been Cook's seemingly better-than-advertised speed -- he ran the 40-yard dash in 4.46 seconds at February's scouting combine -- and ability to adjust to the ball in the air. He's also quelled quiet concerns about his willingness to tackle.
Yet it took roughly 30 practices and two preseason games for the Vikings to move Cook from the left side, where he was serving as an insurance policy for veteran starter Antoine Winfield, to the wide-open competition for replacing disabled Cedric Griffin on the right.
"We're worried a little bit about the footwork" on the right side, coach Brad Childress said. "I think he's done some OK things over there."
Asked specifically if Cook has made enough progress to have a legitimate chance at winning the starting job, Childress said, "He's made a lot of progress, yeah. Whether we in fact decide to do that, we'll just have to see. But he's done some good things."
The difference between Cook and his competitors is he has rare physical traits. He's so long some NFL teams scouted him as a safety and so athletically gifted -- he posted a record 11-foot broad jump at the combine -- his stock soared after a strong Senior Bowl week.
Teams that were wary of Cook cited his concerns about his work ethic and communication skills. So far, neither has proven to be much issue.
"I've always been a confident guy," Cook said. "Without confidence, you're nothing."
And the Vikings were confident enough Cook can play immediately they were willing to part with veteran nickelback Benny Sapp on Wednesday, leaving them with only four healthy corners who will make the roster.
Sheppard, 29, earned two Pro Bowl nods in his prime and has by far the most experience.
Allen, 22, has drawn praise for his growth throughout his first full NFL offseason.
Cook isn't as quick and doesn't have the flexibility to play inside. There also remain concerns about how his youth will show up if teams start game planning to attack him.
Sheppard and Allen combined haven't made as many plays as Cook, though, nor do they have the rookie's size.
So, even if he doesn't take over by the opener Sept. 9 at New Orleans -- a possibility Cook says he hasn't thought about -- he certainly seems to be on track for a significant role sooner than later.
Is Cook ready to start in this league?
"Only will time will tell," he said. "Once the lights come on and that whistle blows for the first kickoff -- we'll tell then."

subset: commoncrawl


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|Boone Tot Lot: "Things are going well"
|Written by Lauren Ohnesorge
|Thursday, 05 July 2007 21:09
According to Stephen Poulos of Parks and Recreation, renovations of the Boone Tot Lot are going better than expected.
Mulch will soon be added. The construction company is pleased with the way things are going, Poulos said.The town is even paving the walking track.
In fact, the park could be ready by the end of next week. Poulos promised more information on Monday- but is excited at the progress so far.
|Share This Article:


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WINS COLLIERThis year's Collier Trophy has been awarded to
the international team behind the International Space Station. The
National Aeronautic Association announced the award on Wednesday. The
association says it selected the station "for the design, development,
and assembly of the of the world's largest spacecraft, an orbiting
laboratory that promises new discoveries for mankind and sets new
standards for international cooperation in space." NASA Administrator
Charles Golden said the award "is a testament to the dedication and hard
work of thousands of people around the world." More...
CONTROLLER AT JFK?Bring your-kid-to-work-day took
on a decidedly different turn last week when a tower controller at New
York's JFK evidently had a child communicate with aircraft on the
outbound local frequency. Recorded audio reveals the child made a
handful of transmissionsobviously coachedand the controller
said on the frequency "that's what you get guys when the kids are out of
school." The kid's directives included takeoff clearances and frequency
switches to departure. Although the pilots on frequency appeared amused,
the FAA and the controller's union, NATCA, are not.
Content:Click here to
listen to the audio (MP3 file)
CUTEEveryone has an opinion on the controller who took his
son to work and gave him a little time on the radio. AVweb's Paul
Bertorelli doesn't think it's a security crisis, but he does have some
advice to offer on the AVweb Insider blog: "You might wanna
run this by some adults before you try it again." Read
more and add your own comments here. More...
OF THE WEEK: KIDS' STUFF ON THE RADIO?Making headlines this
week is a controller who brought
his son to work in the ATC tower. Reactions
run the gamut, but we'd like to hear yours. What was your take on
the "kid in the control tower" story?Plus: Last week,
we asked AVweb readers what stance GA should take toward the
future of lead in avgas and got a pretty clear answer. Click
through to find out how your fellow readers answered. More...
FORWARD"Around the world, women plan to celebrate
the 100th anniversary of the first time a woman earned a pilot
certificate by taking a woman or girl for her first flight in a
general-aviation aircraft during the week of March 6 to 12. Raymonde De
Laroche, a French balloonist, learned to fly a fixed-wing aircraft and
was the first woman to receive a pilot certificate, on March 8, 1910. So
far, pilots from the U.S., France, Spain, Mongolia, and many other
countries have signed up to participate in what they hope will be a
world-record-setting event. The Ninety-Nines, Women in Aviation
International, the International Society of Woman Airline Pilots, EAA,
and other groups have signed on to help with the effort. "Nothing can
inspire a woman to learn to fly more than meeting a woman who became a
pilot," say the organizers of the Centennial of Women Pilots. Women who
want to participate in the record attempt must pre-register at the
group's Web site.
Related Content:Click
for a podcast interview about the Centennial with Mierelle Goyer
AIR SHOW OPENS WITH HOPE, TRAGEDYIndia Aviation 2010 launched on Wednesday amid high
hopes for expanding markets in the region, but the opening day airshow
was marred by a crash that killed two pilots. Spectators from more than
100 countries were on the show site in Hyderabad when a Kiran MK-II, a
military jet trainer, crashed into a nearby apartment building. Four
people in the building were hurt, two seriously. One pilot reportedly
ejected but the chute failed to deploy, and the other died in the crash.
They were flying with Sea Breeze (Sagar Pawan), a four-ship naval
aerobatic team that launched in 2003. A video posted by CNN shows the accident aircraft
veering off from the other airplanes, apparently out of control, as they
pull up from a maneuver. General aviation manufacturers from the U.S.
attending the show include Cessna, which is introducing its Citation Mustang
jet there, and Hawker Beechcraft (PDF), which is showing a King Air 350 along with two
of its bizjets, the Hawker 750 and Hawker 4000. More...
DC-3 FORMATION AT 40Organizers of a mass arrival of
DC-3s and C-47s at AirVenture Oshkosh this year now expect 40 aircraft
to take part. The original goal was 25 aircraft making an hour-long
flight from Rock Falls, Ill., to Wittman Regional Airport for a
formation flyby at 1,000 feet to celebrate the 75th anniversary of the
first flight of the iconic aircraft. Organizers were deluged with
requests to participate in the flight, which will be the largest
formation of Douglases since the Second World War. The current record is
27, set in South Africa in 1985. There are 12 aircraft on standby to
fill any slots that open up before the flight. Once in Oshkosh, the
aircraft will be the centerpiece of festivities throughout the week
including a one-of-a-kind heritage flight. More...
"FLYING" HOVERCRAFTNew Zealander (he's half Australian) Rudy
Heeman has, over 11 years, transformed his hovercraft into a
wing-in-ground-effect vehicle, and now it's for sale. Heeman says he's
found the ideal flight altitude under the vehicle's 7-meter wingspan to
be about 1.5 meters, over flat water or land, where he reached a top
speed of about 60 mph in a test. It will hop small bushes or short trees
and, yes, Heeman has hit shrubbery with it (and continued to a safe
landing). Theoretically, the pilot plus one vehicle can cruise at about
55 mph for roughly 140 miles. The project includes parts from six
different cars, including what was originally a 1.8-liter Subaru engine,
and a gas bottle from an old barbeque. Its wings consist of what appear
to be a front and rear aluminum tube spar, foam/fiberglass ribs (four
per side, plus an end rib) and zip-to-close fitted fabric covering --
all of which separate for storage/transport. The vehicle is controlled
by rudder and elevator, actuated by a control wheel (no rudder pedals).
The cockpit includes a GPS and engine gauges, but Heeman has included
other creative refinements. More...
QUIET HELICOPTEREurocopter announced the week of
February 25 new "Blue Edge" and "Blue Pulse" technology that
significantly reduces the noise generated by a helicopter blade. Tested
on an EC155 helicopter, the Blue Edge blade itself created a three to
four decibel drop in noise and then Eurocopter added more technology.
For the blade, itself, Eurocopter dramatically redesigned the shape,
creating what might best be described as a seagull-wing shaped bend at
the blade's tip. It then layered active "Blue Pulse" technology on top
of the Blue Edge design. Blue Pulse adjusts three trailing edge flap
modules 15 to 40 times per second via piezoelectric motors. The flaps
move to reduce the effect of blade/vortex interaction. That interaction
occurs as a trailing blade encounters the vortex of the preceding blade,
causing an audible "slap." And adjusting the interaction dramatically
reduces the slap. For disbelievers, the company has supplied audio. Find
it after the jump.
Related Content:Click here to hear
sound comparisons (MP3)
TRAFFIC UPBusiness aircraft activity is up considerably,
bucking a trend that saw an overall decline in general aviation activity
(it's down 3 percent overall) in the U.S. according to FlightAware. In
its monthly analysis of aircraft movements, the popular online tracking
and data site says private jet traffic is up a whopping 8.8 percent in
February, compared to the same month in 2009. Turboprop was up 2.2
percent but the tale of the tape was in charter and fractional
operations. Charters were up 16.5 percent and fractional traffic 6.5
percent, perhaps reflecting a shift from ownership to charters for
economic and public relations reasons. Every other sector of GA activity
measured by FlightAware was down.
Related Content:Read
the full FlightAware report (PDF)
VISIT IMPACTS HAWAII AVIATORSThe Oahu Aviation Initiative,
an ad hoc coalition of 20 small general aviation businesses in Hawaii,
is asking the federal government to compensate them for $200,000 in
losses they incurred due to almost two weeks of flight restrictions
during President Barack Obama's recent holiday visit to Oahu. The group
is also working with the Secret Service and the TSA to negotiate less
severe restrictions before the next presidential visit to their state.
The restrictions essentially banned flights within a 30-mile radius of
the rented house where the Obama family was staying outside Honolulu.
Pat Magie, president of Island Seaplane Service, told the Honolulu Advertiser that aviation company owners
were not informed of flight restrictions until four days before the
president's arrival, and many of them had no option but to shut down
entirely during the 12-day visit, from Dec. 23 to Jan. 4.
EXECS OPPOSE EPA DEICING RULESNew rules proposed by the U.S. Environmental Protection
Agency to control runoff from aircraft deicing fluids would "create
safety hazards at many airports," the American Association of Airport
Executives says. Under the proposed rules, airports with more than
10,000 annual aircraft departures and 1,000 annual jet departures would
be required to re-capture up to 60 percent of the fluid, rather than
allow it to drain off the pavement, where it can end up in nearby
rivers, lakes, streams and bays. AAAE says the proposal doesn't allow airports enough
time to comply, would impose financial burdens, and the use of
additional fluid recovery vehicles around crowded gate areas could cause
safety issues. "Safe airport deicing procedures are paramount to winter
weather practices," said AAAE Director of Regulatory Affairs Leslie
Riegle. The EPA says stricter rules are needed because airport
discharges from deicing operations can affect water quality. Impacts
include fish kills, contaminated drinking water, and noxious odors in
residential areas and parks, among other effects. More...
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"FBO of the Week" a little more difficult. After some thoughtful
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Aviation at Montreal, Québec's Pierre Elliot Trudeau
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AVweb reader Keith
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OF THE WEEK: AVWEB'S FLYING PHOTOGRAPHY SHOWCASEIce, sleet, snow,
and more ice have been standard issue for the last couple of weeks
across most of the U.S. and in our "POTW" submission box.
Andrew Wall of Ankeny, Iowa
asks, "Will this winter weather ever end? These F-16s have been waiting
for a chance to fly for a long time and certainly won't be doing it
today." More...
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"Brownie, you're doing a heck of a job".
Who can forget that famous George Bush quote from 2005 when George W. complimented FEMA Director Michael Brown on the fantastic job he was doing for the people of New Orleans in the aftermath of the Hurricane Katrina disaster? It could just as easily be coming from the lips of my pick for November's Fredo Award, Rob Stringer, to Rick Rubin. Maybe even from big bro Howard to Rob, for that matter.
I don't mean to pick on Rick. After all he's a man of great accomplishment, most notably of suckering Stringer into a sweetheart deal. But is that really such a tough thing to do?
I thought that it would be interesting to take a look back at Rubin's output since joining Sony Music as co-chairman of Columbia Records. Who can forget the September 2007 New York Times Magazine cover story on Rick by Lynn Hirschberg in which she wrote, "Columbia [Records] didn't want Rubin to punch a clock. It wanted him to save the company. And just maybe the record business."
So I went to Wikipedia and dug into Rick's discography since landing at Columbia. The results are interesting if not somewhat startling in many ways. Let's begin by looking at the albums that Rick has produced or executive produced during his tenure at Sony.
As the Soundscan sales below will show, more than 84% of all of Rick Rubin's records were sold by labels OTHER than Sony!
A few caveats and clarifications though. Eight of these 22 titles are records that Rubin produced for his own American Recordings in which he retains ownership of the masters. Those are indicated with an asterisk (*). Sony distributes all but two and consequently they have to share those profits with Rick. Also, he only contributed one cut on the 2007 Poison album, and that was a track he produced in 1987 taken from the soundtrack of Less Than Zero. Data for The (International) Noise Company was not available, though it would not materially affect the overall numbers. Classic (Better Than I've Ever Been) featuring Kanye West, Nas, KRS-One and Rakim, was a one-off single for Nike with insignificant sales that was only available via digital download and vinyl, so I'll exclude that from my calculations.
Now let's go to the numbers. Here's how Rick's sales break down among all labels he has released product for during this period.
Total 8,003,910
Very impressive.
However exactly 38% of the units Rick has sold for Sony are for his own American Recordings label. 55% of the remaining sales of Columbia-signed artists are for one title, Neil Diamond's Home Before Dark, still not certified gold.
A few other interesting little factoids:
Since joining Columbia, Rubin has had no number one singles on the Billboard charts.
Since joining Columbia, Rick has produced one Billboard number 1 album for the label (Neil Diamond) and three for Warner Music (two Linkin Park and one Metallica.).
Since joining Columbia Records, Rubin has produced zero gold or platinum albums for Sony and 2 platinum and 1 gold for Warner.
Since joining the company, Rick has produced only 4 albums for Columbia Records-signed artists that have been actually released. A fifth is due early next year, the sophomore effort from Grammy winner Adele.
In all of 2010 Columbia Records has had 5 number one albums, 2 from Susan Boyle and 3 from the cast of Glee, none of which are products of the label's A&R department. Two of the three Glee titles are discounted EP's.
The numbers aren't particularly impressive from a Sony perspective, but no one hits it out of the park every time they step up to the plate. And not every artist has fallen in love with Rick like Josh Groban apparently has. U2 rejected several tracks he produced for the band in 2008. Slipknot publicly voiced their displeasure with Rick's "hands off" style and Velvet Revolver's Scott Weiland told Launch Radio why they were not a good match. "If you're gonna work with a producer, unless you're gonna produce something yourselves, if you're gonna pay a producer, get in the trenches with us and work with us," he said. "The Rick thing didn't work out, and, you know, he was working on a couple of other things, Metallica and U2, and so we kind of became very uninspired." Similar story with Crosby, Stills & Nash, who recently fired him from their Columbia Records covers project. Sony Music insiders tell me that Stringer's attempts to get Rick together with several of the label's most prestigious legacy artists have fallen flat as well.
Sources also say that the Rubin regime has killed morale in the company. Rick doesn't like to fly and consequently doesn't have any presence at the New York headquarters. He doesn't keep an office at the new Sony digs in Beverly Hills and although he does have a Sony Music email address, he only responds to emails sent to his private address, privy to just few select staff members. If anyone needs to meet with him they have to fly to LA and trek up to his house in Hollywood, which one insider refers to as "the Addams Family mansion". And since Rick keeps "record producer" hours, the idea of reaching him during the normal business day is almost impossible. A&R meetings at first slowed down and eventually stopped altogether. With the A&R team unable to contact him, they would be forced to go to Barnett, who apparently hated reaching out to Rick.
What makes this truly ridiculous is that Rick had insisted that Sony, at great expense, relocate offices from their campus in Santa Monica into the old CAA building, a white elephant if ever there was one. The mausoleum on Wilshire Blvd, that Mike Ovitz built in tribute to himself had the cache of being an I.M Pei design, thus diverting Rick from his initial plan to de-corporatize Sony's image and house itself in funkier digs like a warehouse in Venice or a downtown LA loft. The only thing was that Ovitz had to approve any and all artwork that went into his building, so there went the funky artist posters traditionally found taped to the walls of record company offices. But one thing worked out well. The new offices are across the street from the 5-star Peninsula Hotel, where Stringer and Barnett are the only labels execs allowed to stay. There's always something to be said for convenience. At least it cuts down on limo bills.
It is a fairly open secret that Columbia Records co-chairman Steve Barnett was never happy about being saddled with Rick and hated the decision from Day One. Steve is known to have told associates that his biggest regret is having agreed to the arrangement in the first place, a demotion of sorts. He and Stringer are boyhood chums, so it was a particularly hard pill to swallow. Though he puts on a good front, behind closed doors Barnett takes every opportunity to disparage Rubin to anyone who will listen. According to one of my Wikisources from 550 Madison Ave., the tales of Barnett's screaming matches with Rubin rival those of Don Ienner with…well, everyone.
In spite of all of the chaos, Rob Stringer continued to stand by his man. As the story goes, Stringer felt that Steve Barnett was not a "music guy" so he wanted to bring in a "sizzle" guy like Jimmy Iovine, someone who established artists would relate to and new artists would be thrilled to meet.
At first Rubin's hiring looked like a stroke of brilliance, a real coup. It was like manna from heaven that would revitalize the greying iconic Columbia Records. Rick just won the Grammy for Producer of the Year for his work with Columbia's own Dixie Chicks among other acts he had worked with the previous year.
Outside observers were secretly laughing at Stringer since everyone knew that Rubin's first go-round with Columbia was a disaster with his American Recordings label losing millions. At the time, Sony couldn't wait to off him to Warner Music, which is exactly where Stringer found him. Junior, being only slightly smarter than Stringer, knew how much Sony wanted him and exactly how much Rubin had lost for Warner. Junior smelled blood and the more he said "no" to Stringer the more Rob wanted Rick. Ultimately Sony paid a king's ransom to extricate Rubin from his Warner Music deal early, even committing to re-releasing several flop American Recording masters that had been gathering dust on the shelves at the Bunny Ranch.
But things didn't seem to work out quite as Stringer had hoped. Despite growing complaints and discord between Barnett and Rubin, Stringer, still convinced of the brilliance of his decision, kept telling the troops that Rick was "unconventional" but delivering exactly what he'd hoped he would, much like his defense of Amanda Ghost. Staffers were being hired and fired with the frequency of Macy's revolving door on Black Friday. It was starting to look like something akin to Michael Eisner's ill-fated hiring of Michael Ovitz to run Disney, a move that led to both of their demises.
Even though he reportedly has at least one foot out the door already, many reports have characterized him as being "psychologically gone", at the end of the day Rubin's not really to blame. Any failure lies with the architects of the harebrained idea to hire him in the first place. After all, they knew what they were signing up for before they opened the piggy bank. Rubin surely didn't present himself as a corporate suit or mislead them in any way. His eccentricities and work habits are no secret. Rob Stringer got exactly what he bargained for. I'm sure his intentions were good; his efforts to shake things up were admirable, but misguided. It's great to think outside of the box, but not beyond the realm of reality. You can't blame Rick for taking advantage of others' stupidity. Actually it turns out that he's the smartest of the lot and the only winner in this picture.
Now that the ninjas back home in Japan are looking for a new corporate president to lighten the load on Sir Howard and establish a succession (in other words, show him the door), rumors are staring to fly. One has the BBC courting Howard to be their next chairman. Another has Doug Morris replacing Rolf Whatever-His-Name-Is as Sony Music CEO early next year. It's supposed to be a done deal, in which case expect Universal CEO Lucien Grainge to eat Sony's lunch, especially since RCA/Jive CEO Barry Weiss has left Sony to head UMG's east coast operations. I wouldn't be surprised to see Jimmy Iovine eventually replace Rob Stringer. Just another case of rearranging the deck chairs. Stringer loyalists like to float the idea that the Weiss exit clears the way for Rob to assume the position—Rolf's, that is. But word is that he's already been passed over for it. Could the Sony boys in Tokyo really trust Rob's judgment at this point? If Rob does end up leaving Sony, a word of warning to Geoff Taylor, current CEO of the BPI in London: somebody may be looking to get your job.
So who's to blame for this fiasco? It's certainly easy to point the finger at Rob Stringer. He's the driver behind what could be considered one of the biggest major label boondoggles of the decade. He's the guy who signed off on all of Rick's mishegas. When the dust finally settles it wouldn't be surprising if this little "experiment" ends up costing Sony $100 million or more, especially when you consider the massive billing differential between Rubin's Sony product and that with other labels (minimally $60 million). And let's not forget the Amanda Ghost/Epic Records disaster that cost Sony quite a few shekels, and embarrassment, as well. On the surface it certainly appears that Stringer is in over his head and has blown it. But let's face it: it all ultimately comes down on big brother Howard's shoulders. You'd think that at some point he would say to Rob, "What the hell are you doing?"
In the final analysis it all boils down to the same old story—a fable of corporate record industry hubris run amok. All that's missing is the cocaine and hookers. Ah, the good old days. But in a strange way it's kind of comforting to know that some things just never change.
Related Posts:
Leaving Town On The Marrakesh Express
TMV Video Interview: Mike Smith, Managing Director – Columbia Records UK
Exclusive Interview: Ross Fraser, Director AnR – Sony Music Australia


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Technology in Healthcare
As follow-up to our recent post on the issues that the Centers for Medicare & Medicaid Services (CMS) is experiencing with its Open Payments database, there is new information that additional data also may be excluded when...more
The Final Rule implementing the Physician Payment Sunshine Act was announced on February 1st and published in the Federal Register on February 8th. The Final Rule establishes procedures for drug and device manufacturers to...more
On February 8, 2013, 16 months after the statutory deadline, the Centers for Medicare & Medicaid Services (CMS) published in the Federal Register the final regulation implementing the physician payment transparency...more
On Friday, February 1, 2013, the Centers for Medicare and Medicaid Services (CMS) released the highly anticipated final rule to implement the federal Physician Payments Sunshine Act (the "Sunshine Act"). The final rule will...more
In an action that will have broad implications for drug and device manufacturers, researchers, distributors, teaching hospitals and physicians, on February 1, the Centers for Medicare and Medicaid Services (CMS) publicly...more
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Dr. Mark S. Box's Ratings
i have called and called for 4 days with not ONE return call when i have left messages, even went to office on day two, on hold for over 15 minutes today still trying to schedule appointment!
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Dr. Box is prompt and will even work you in the same day if you are ill. He is a good listener and knowledgeable. Most of all is understanding and truly caring. I have the utmost respect for him and I think he is a wonderful physician.
Was this rating useful? 0 [[ userState['ratings'][1120190].votes_count ]]
He is not sensitive to the needs of patients, especially those who do not have insurance. He was condescending, and made me feel that I was wasting his time.
Was this rating useful? 0 [[ userState['ratings'][1120189].votes_count ]]
Dr. Box has been both my Internest as well as my Rheumatologist since 1994. He has ALWAYS been a team player with my vast medical team, conferred with my other specialists when necessary, ALWAYS returned my calls when I've specified that they were "personal", within no longer than 12 hours - including evenings and weekends, and has ALWAYS had my best interest at heart. If I were to lose him for some reason, I would be completely devestated. I KNOW I could NEVER find another doctor like Dr Box who knows and completely understands all of both the medical AND the emotional ramifications of the numerous conditions I suffer with daily. He's #1 in my book - there's no one that even comes close to him It's a shame he's so overwhelmed now that he can no longer accept new patients. So many people are missing out on the experience of this wonderful, bright, caring doctor - one who gives you all the time you need. He really DOES care. He LISTENS. He's THE BEST!
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Dr. Box is THEE BEST. I would not have anyone else! He has saved my life! I heard him talk at a meeting also.
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Dr. Box is the BEST! I thought I could not be helped with my fibro until I heard Dr. Box speak at a meeting and I knew immediately, this was the doctor I needed to see to put some sense back into my life and help get rid of my constant pain. I feel Dr. Box has saved my life!
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I have found no other doctor, let alone a specialist, with such a caring demeander with such extensive knowledge in his field. I would follow Dr. Box anywhere because of his abilities.
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Until seeing Dr. Box, I thought Kansas City was truly a 3rd world country for medicine & treatment. He is professional, extensive with his medical knowledge & healthful recommendations, and I was amazed by how well he listened & heard what I was saying. He is NOT your typical Kansas City Dr. I wish I had found him sooner.
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Prompt,answers questions personally and returns phone calls same day. Very knowledgable in rheumatology. Some of staff are not. Although he has a very busy practice does not make you feel rushed and is not threatened if you disagree. Does not cut you off as a patient when insurache changes to one that may not pay as well. fushed
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Dr. Box is one of the best in knowing what's new in rheumatology and what treatments are available, what experiences patients have had with different treatments, etc., but he is very poor at really listening and trying to get to the bottom of a problem that isn't "typical". He's quick to diagnose, write a Rx and move on.
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If the Hogwarts crew were to reunite for yet another sequel, it might be called 'Harry Potter and the Mixed Blessing Windfall.'
The windfall at issue here is the billions earned by the Potter film franchise, a jackpot that will expand one last time with the release of series capper 'Harry Potter and the Deathly Hallows, Part 2' this week. On the one hand, the franchise's success has been a boon to the British film industry, pouring hundreds of millions of dollars into the U.K. filmmaking community, showcasing Great Britain's wealth of acting talent, and making England more attractive as a film-shoot location for international productions. On the other hand, the influx of Hollywood money (even as homegrown funding sources are jeopardized) threatens to turn British movies into Hollywood clones, destroying the local flavor and character of a national cinema that was once idiosyncratic, groundbreaking and unique.
It may seem churlish to grumble about the impact J.K. Rowling's boy wizard has had on British cinema. After all, thanks to her insistence, the movies were all shot on English soil, with British crews and technicians (and even British special effects houses) and all-U.K. casts. For 10 years, the Potter films were to British actors what the 'Law & Order' TV franchise was to New York City actors: a reliable source of employment that gave a job to nearly every local with a SAG card. (Well, yes, there were a handful of prominent British thespians who never waved a wand at Hogwarts.)
And now that the series is done, it's not as if Warner Bros. is packing everything up and taking it all back to Burbank. In fact, the Hollywood studio purchased Leavesden, the studio where all eight movies were shot, and has pledged to invest another $100 million to expand the facility. American productions will be filming in England for some time to come. This year alone, such prominent non-Potter projects shot in England include 'Pirates of the Caribbean: On Stranger Tides,' Martin Scorsese's upcoming 'Hugo,' and this month's 'Captain America: The First Avenger.' (Insert ironic outsourcing joke here.)
But with all these Hollywood productions, where is the homegrown British cinema? If everyone in the British filmmaking community is working on American movies, who's minding the store?
One reason Hollywood likes filming in Britain is that the government offers generous tax credits to foreign companies shooting there as long as they put a sufficient percentage of Britons on the payroll. So those tax incentives (as well as the films' profits) represent money not being plowed back into the local economy.
Still making strictly British films are independent production companies like Working Title, but otherwise, there's no counterpart to the Hollywood studio system. As a result, only a few dozen British movies are made each year.
For a long time, there was government funding available for modest-budget movies. It was national lottery money, distributed by the U.K. Film Council. Throughout the first decade of this century, the council provided £160 million ($258 million) in seed money for 900 movies, including such hits as 'Bend It Like Beckham,' 'Gosford Park' and 'The King's Speech.' (Yes, 'Gosford Park' had an American director, but it had a British writer, a mostly British cast and decidedly British subject matter.) Last year, however, the British government (on its current austerity kick) disbanded the U.K. Film Council, prompting much protest in the local film industry.
The reason given for abolishing the council was its supposedly high overhead; in fact, the jeopardized lottery funds will still be made available to filmmakers via the supposedly more efficient British Film Institute. It's still not clear, however, whether the BFI will distribute money in the same pattern (that is, spreading out the risk by funding many low-budget films with an eye toward modest returns) or go for a more Hollywood model (funding a handful of big-budget spectacles in the hope that they'll attract a mass audience and blockbuster revenues).
Which approach will the BFI take? Prime Minister David Cameron seemed to suggest the latter in remarks last November. Citing the 'Potter' series as an example British filmmakers could learn from, he said, "We have got to make films that people want to watch and films which will benefit beyond themselves as they will also encourage people to come and visit our country."
Many in the filmmaking community took this to mean that the industry should focus on commercial, Hollywood-style films that serve as chamber-of-commerce infomercials for tourists. A more measured set of remarks came later that month from culture minister Ed Vaizey, who suggested that the imported and homegrown film industries have a relationship that's symbiotic, not antagonistic, and that they can both flourish without damaging each other.
Still, it seems a lot of British movies have already been following Cameron's advice. Over the past decade or so, it seems that the British movies that have become the biggest hits already have a lot of American DNA. The Guy Ritchie-style gangster movies would be unthinkable without the stylistic influence of Quentin Tarantino. Richard Curtis' romantic comedies (including 'Four Weddings and a Funeral,' 'Notting Hill,' and 'Love Actually') all depend on Anglo-American casts and all mine humor from the temperamental differences between Brits and Yanks. Even 'The King's Speech' seems less a British costume drama than a formula-fitting effort to make the kind of British drama that American audiences (trained by years of watching Miramax imports) would like. (There's the costumes, the World War II-era setting, Colin Firth and Helena Bonham Carter, and just a hint of naughtiness.)
British filmmakers didn't always look to Hollywood for inspiration. In the 1940s and '50s, the Ealing studio comedies ('Kind Hearts and Coronets,' 'The Ladykillers') were dark satires (darker than most American comedies) lampooning characteristically English personality types. The 1960s saw a revolution in British filmmaking that (along with British Invasion rock 'n' roll acts) made London the world epicenter of hipness - from the kitchen-sink realism of John Osborne's dramas to the sexually liberated young adults in movies like 'Alfie' and 'Darling,' to the gory yet elegant horror films made by the Hammer studio (usually starring dapper Christopher Lee and Peter Cushing), to the state-of-the-art spy thrillers (the James Bond movies, Michael Caine's 'Harry Palmer' series, John le Carré's 'The Spy Who Came in From the Cold').
British films began to slump in the '70s, a decade that also saw an increasing number of major Hollywood productions shoot in England (notably, the 'Star Wars' and 'Superman' movies). The '80s and early '90s saw something of a comeback, led by the Merchant/Ivory team (adapting classic English novels into crowd-pleasing costume dramas) and George Harrison's Handmade Films (quintessentially English comedies, like the Monty Python films and 'Withnail & I'). The '90s also saw maverick directors from England, Scotland, and Ireland (Mike Leigh, Ken Loach, Danny Boyle, Neil Jordan, Jim Sheridan) break through to worldwide audiences despite their regional subject matter and thickly accented casts.
And then, along came Harry.
It's unlikely that there will ever be a franchise this huge again. Recent attempts to create new, kid-friendly, Potter-like franchises on British soil ('The Golden Compass,' 'Stormbreaker') have failed. The Narnia movies (three have been made so far out of a projected series of seven) haven't been as consistent in quality or box office appeal as the Potter pictures.
So 'Harry Potter' may not be the most viable model for the British cinema of the future. British filmmakers, bureaucrats, and even visitors from Hollywood might want to keep that in mind, rather than turning away from the quirky, eccentric, modestly-scaled, independent-minded movies at which British cinema has traditionally excelled.
Follow Gary Susman on Twitter: @garysusman.
CATEGORIES Features, Hot Topic, Harry Potter, Summer Movies, New Releases


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Utah Jazz v Atlanta Hawks
Ivan Johnson and Devin Harris of the Atlanta Hawks goes for the loose... Nieuwsfoto'sAtlanta,Atlanta Hawks - Basketbalteam,Bal,Basketbal,Basketbal - NBA Pro,Devin Harris,Georgia,Horizontaal,Ivan Johnson - Basketball Player,Philips Arena,Sport,Utah Jazz - Basketbalteam,Verenigde StatenPhotographer Scott CunninghamCollection: National Basketball Association 2013 NBAEATLANTA, GA - JANUARY 11: Ivan Johnson #44 and Devin Harris #34 of the Atlanta Hawks goes for the loose ball against the Utah Jazz on January 11, 2013 at Philips Arena in Atlanta, Georgia. NOTE TO USER: User expressly acknowledges and agrees that, by downloading and/or using this Photograph, user is consenting to the terms and conditions of the Getty Images License Agreement. Mandatory Copyright Notice: Copyright 2013 NBAE (Photo by Scott Cunningham/NBAE via Getty Images)