text:
Tandem Auto Transplantation in Myeloma Patients With <12 Months of Prior Treatment
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study is designed to decrease toxicity associated with prior tandem transplant protocols by reducing the intensity of induction, consolidation and maintenance therapy, while increasing event-free survival by adding bortezomib (Velcade®), thalidomide, gemcitabine and carmustine to the transplant regimens to down-regulate the rescue of myeloma cells by the micro-environment and to prevent DNA repair post high-dose alkylating agent therapy. By reducing drug resistance, it is hoped that 3-year event-free survival will be increased significantly when compared to Total Therapy II. Additionally, participants will have the option of providing biospecimens for a sub-study evaluating gene expression profiling at specific timepoints to better understand drug-resistance in myeloma, and to determine whether there are genes or gene products in the resistant population that can be targeted by novel therapies.
Multiple Myeloma
Drug: DPACE (Dexamethasone, Cisplatin, Adriamycin, Cyclophosphamide, Etoposide)
Procedure: Transplant 1 (Velcade, Thalidomide, Dexamethasone, Melphalan)
Procedure: Transplant 2 (Velcade, Gemcitabine, Carmustine, Dexamethasone, Melphalan)
Drug: Consolidation VDT-PACE (Velcade, Dexamethasone, Thalidomide, Cisplatin, Adriamycin, Cyclophosphamide, Etoposide)
Drug: Maintenance Year 1 (Velcade, Thalidomide, Dexamethasone OR Velcade, Revlimid, Dexamethasone OR Velcade, Cyclophosphamide, Dexamethasone in 28 day cycles x 12)
Drug: Maintenance Year 2 (Revlimid and Dexamethasone in 28 day cycles x 12)
Phase 2
|Study Type:
|Study Design:
|Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|Tandem Autotransplantation for Multiple Myeloma in Participants With Less Than 12 Months of Preceding Therapy, Incorporating Velcade (Bortezomib) With the Transplant Chemotherapy and During Maintenance
- Event-Free Survival (EFS) [ Time Frame: 8 years ] [ Designated as safety issue: No ]To determine whether, in comparison to Total Therapy II, the median Event-Free Survival (EFS) can be increased from 4.8 years to 7.2 years, which represents an increase in median EFS of approximately 50%, based on an intent-to-treat analysis.
- Identification of Drug Resistant Genes [ Time Frame: 5 years ] [ Designated as safety issue: No ]To determine whether repeated bone marrow samples analyzed for gene expression profiling (GEP) can identify genes related to drug resistance in myeloma. The drug resistant genes or the gene products might then be targeted specifically to eradicate myeloma cells surviving tandem transplantation.
- Number of grade 3 non-hematologic and grade 4 hematologic serious adverse events associated with the addition of bortezomib, thalidomide, and dexamethasone into autologous transplant regimens. [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]To determine whether bortezomib, thalidomide and dexamethasone with transplant 1 and velcade/gemcitabine with transplant 2 can be safely incorporated into well-tested pre-transplant regimens of high-dose melphalan and carmustine/melphalan in doses equivalent to the BEAM(BCNU, etoposide, arabinoside, melphalan)regimen. Treatment-related toxicities will be compared to those reported in the literature using similar intensive approaches.
- Overall survival [ Time Frame: 10 years ] [ Designated as safety issue: No ]To determine the median overall survival based on an intent-to-treat analysis, which should exceed 10 years, based on the projected 10-year survival of Total Therapy III, keeping in mind that participants are included in this protocol with up to 12 months of prior therapy.
|Study Start Date:
|May 2012
|Estimated Study Completion Date:
|March 2014
|Primary Completion Date:
|July 2013 (Final data collection date for primary outcome measure)
Drug: DPACE (Dexamethasone, Cisplatin, Adriamycin, Cyclophosphamide, Etoposide)
This study is targeted towards patients who have been diagnosed with Multiple Myeloma, POEMS(Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes), or myeloma plus amyloidosis and have had no more than 12 months of prior treatment. Furthermore, participants cannot have had a prior autologous or allogeneic transplant. The study schema consists of one round of induction chemotherapy, two transplants, one round of consolidation chemotherapy, and two years of maintenance treatment. This study design differs from its historical predecessors in the following manner:
- In contrast to Total Therapy II and III, which only allow enrollment of patients with one cycle or one month of treatment prior to enrollment, the proposed study allows enrollment of participants with up to 12 months of prior treatment.
- Induction therapy has been reduced to a single cycle.
- Bortezomib and thalidomide have been added to the transplant regimen.
- Carmustine is added to the second transplant.
- Gemcitabine is added to the second transplant regimen.
- Consolidation treatment has been reduced to a single cycle.
- The first year of maintenance consists of 12 28-day cycles of bortezomib,dexamethasone, and either thalidomide, lenalidomide, or cyclophoshamide. The second year of maintenance therapy consists of lenalidomide and dexamethasone.
- The novel agents thalidomide and bortezomib are not introduced upfront, but only with transplantation, consolidation, and maintenance.
|Ages Eligible for Study:
|18 Years to 80 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Participants must have had a diagnosis of symptomatic MM, MM + amyloidosis, or POEMS (osteosclerotic myeloma: Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes) requiring treatment. Participants with a previous history of smoldering myeloma will be eligible if there is evidence of progressive disease requiring chemotherapy. Note that study participants do not need to have active disease at the time of study entry, as participants may have received up to 12 months of prior chemotherapy, which might have induced a response.
- Protein criteria must be present (quantifiable M-component of IgG, IgA, IgD, or IgE and/or urinary kappa or lambda light chain, Bence-Jones protein, or Free Kappa Light Chain or Free Lambda Light Chain) in order to evaluate response. Non-secretory participants are eligible provided the participant has > 20% plasmacytosis OR multiple (>3) focal plasmacytomas or focal lesions on MRI.
- Participants must have received no more than 12 months of prior chemotherapy for this disease. Participants may have received prior radiotherapy provided approval has been obtained from the PI.
- Participants must not have had a prior transplant.
- Participants must be 18-80 years of age at the time of study entry.
- Ejection fraction by ECHO or MUGA of ≥ 40% performed.
- Participants must have adequate pulmonary function studies, > 50% of predicted on mechanical aspects (FEV1, FVC) and diffusion capacity (DLCO) > 50% of predicted (adjusted for hemoglobin). If the participant is unable to complete pulmonary function tests due to disease related pain or condition, a participant may still be enrolled provided that the PI or enrolling investigator documents that the participant is a transplant candidate.
- Participants must have a creatinine < 3 mg/dl and a calculated creatinine clearance >30mL/min. The Cockroft-Gault equation may be used to obtain calculated creatinine clearance.
- Participants must have a performance status of 0-2 based on ECOG criteria. Participants with a poor performance status (3-4)based solely on bone pain will be eligible, provided there is documentation to verify this.
- Participants must sign the most current IRB-approved study ICF (Informed Consent Form).
Exclusion Criteria:
- Prior autologous or allogeneic transplant.
- Platelet count < 30 x 109/L, unless myeloma-related. If MM-related, the enrolling investigator must document this.
- > grade 3 neuropathy.
- Known hypersensitivity to bortezomib, boron, or mannitol.
- Uncontrolled diabetes.
- Recent (< 6 months) myocardial infarction, unstable angina, difficult to control congestive heart failure, uncontrolled hypertension, or difficult to control cardiac arrhythmias.
- Participants must not have light chain deposition disease-related renal failure or creatinine >3 mg/dl.
- Participants must not have a concurrent malignancy unless it can be adequately treated by surgical, non-chemotherapeutic intervention. Participants may have a history of prior malignancy, provided that he/she has not had any treatment within 365 days of study entry AND that life expectancy exceeds 5 years at the time of study entry.
- Participants must not have life-threatening co-morbidities.
- Women of child-bearing potential must have a documented negative pregnancy test documented within one week of study entry. Women and men of reproductive potential may not participate unless they have agreed, by signing the study ICF, to use effective contraceptive method(s) as outlined in that form.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01548573
|United States, Iowa
|University of Iowa Holden Comprehensive Cancer Center
|Iowa City, Iowa, United States, 52242
|Principal Investigator:
|Guido J Tricot, MD, PhD
|University of Iowa
Additional Information:
No publications provided
|Responsible Party:
|Guido Tricot, Director, Holden Cancer Center Bone Marrow Transplant and Myeloma Program, University of Iowa
|ClinicalTrials.gov Identifier:
|NCT01548573 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 29, 2012
|Last Updated:
|November 26, 2013
|Health Authority:
|United States: Federal Government
United States: Food and Drug Administration
United States: Institutional Review Board
Keywords provided by University of Iowa:
multiple myeloma
POEMS (Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes)
bone marrow transplant
Additional relevant MeSH terms:
Multiple Myeloma
Neoplasms, Plasma Cell
Blood Protein Disorders
Cardiovascular Diseases
Hematologic Diseases
Hemorrhagic Disorders
Hemostatic Disorders
Immune System Diseases
Immunoproliferative Disorders
Lymphoproliferative Disorders
Neoplasms by Histologic Type
Vascular Diseases
Dexamethasone 21-phosphate
Dexamethasone acetate
Etoposide phosphate
Liposomal doxorubicin
Alkylating Agents
ClinicalTrials.gov processed this record on October 06, 2015


text: Berlin's Oliver Doerell and Stephan Wohrmann return with their third album on City Centre Offices as Swod, following 2004's Gehen and 2007's Sekunden. It's a smart, emotionally involving sequence of melancholic, minimalist sketches, characterised by piano, quivering acoustic timbres and rich electronic ambience- it's generously melodic and sweetly textured stuff, but with an occasionally scratchy, disturbed atmosphere that reminds of us vintage Mille Plateaux or Dettinger. For fans of Tim Hecker, Porn Sword Tobacco, Max Richter, A Winged Victory For The Sullen and other moody swoonsters.

subset: commoncrawl


text:
The Carrier syllabary, or Déné Syllabics, was devised by Father Adrien-Gabriel Morice in 1885. He adapted it from the syllabic writing systems developed for the Athabaskan languages of the Northwest Territories of Canada by Father Emile Petitot.
The Carrier syllabary was fairly widely used for several decades for such purposes as writing diaries and letters and leaving messages on trees. Though the syllabary is no longer used or understood by many people, there has been a recent revival of interest in it and it occasionally appears on plaques and memorials.
In the 1960s, the Carrier Linguistic Committee in Fort St James developed an alternative writing system based on the Latin alphabet. This system is now the most popular writing system for Dakelh.
Carrier (Dakeł / ᑕᗸᒡ), an Athabascan language spoken by 3,600 people in central British Columbia, Canada.
This syllabary has also been adapted to write a number of other indigenous languages of North American such as Cree and Inuktitut.
Yinka Déné Language Institute
Information about Déné syllabics
Carrier - Canadian Aboriginal Syllabics transliteration system
Bamum, Caroline Island Script, Celtiberian, Cherokee, Cypriot, Eskayan, Hiragana, Iberian, Katakana, Kpelle, Loma, Mende, Mwangwego, Ndjuká, Nüshu, Vai, Yi


text:
I Dated a Robot
|The topic of this article may not meet Wikipedia's general notability guideline. (June 2011)
|"I Dated a Robot"
|Futurama episode
The crew and Lucy Liu's head hide from the renegade Liu-bots.
|Episode no.
|Season three
Episode 15
|Directed by
|James Purdum
|Written by
|Eric Kaplan
|Production code
|Original air date
|May 13, 2001
|Opening caption
|"No Humans Were Probed In The Making Of This Episode"
|Opening cartoon
|"Censored" (1944)
|Guest actors
Lucy Liu as herself
"I Dated a Robot" is the eleventh episode in season three of Futurama. It originally aired on May 13, 2001.
After the crew sees an episode of The Scary Door, Fry decides to do all the things he always wanted to do, and the Planet Express crew obliges. After demolishing a planet, visiting the edge of the universe, and riding a dinosaur, one of his few remaining fantasies is to date a celebrity. Fry and Leela venture into the Internet to visit nappster.com and download a celebrity's personality. Fry downloads the personality of Lucy Liu into a blank robot, which begins projecting an image of her.
Fry and the Lucy Liu robot begin dating, aided by her being programmed to like Fry. The other Planet Express employees, concerned about his relationship (especially Bender, who sees it as a sign that all of the fembots are being seduced by human men, referring to it as "metal fever"), show him the standard middle-school film that predicts the destruction of civilization if humans date robots. Unfortunately, Fry ignores the movie, and keeps making out with his Lucy Liubot.
Bender, offended by the concept of competing with humans for the attention of female robots, sets off with Leela and Zoidberg to shut down Nappster. In the Nappster building a broken sign eventually reveals that the company is actually "Kidnappster". Breaking into the back room Bender discovers that Nappster has been kidnapping the heads of celebrities and making illegal copies of them. Leela grabs Lucy Liu's head, and the four take off. The Nappster CFO loads a backup disk of Lucy Liu, and creates a horde of Lucy Liu robots ordered to kill (by having their settings changed from "competent lawyer" to "erotic assassin").
Leela and her group, running from the robot horde, duck into a movie theater, where Fry is seeing a movie with his Lucy Liu robot. Everyone ducks into the projection room. Zoidberg discovers a five-ton bag of popping corn, and sends it pouring onto the robots on the theater floor. The robots eat their way out from under the corn and start shooting popcorn kernels from their mouths at the room. Fry's Liu-bot points the projector at the other robots, and the heat causes the popcorn to pop, bursting the robots. At the request of the real Lucy Liu, Fry blanks his robot. A hypocritical Bender begins dating & kissing Lucy Liu's head much to Fry's anger.
The episode was originally entitled "J-Lo Dolly" and have Fry fall for a robot version of Jennifer Lopez, but the title was dropped after the initial scripting stage.[1]
Broadcast and reception[edit]
In its initial airing, the episode received a Nielsen rating of 3.8/8, placing it 76th among primetime shows for the week of May 7–13, 2001.[2]
Cultural References[edit]
- The "I Dated a Robot!" movie is a parody of school propaganda films such as Reefer Madness, Duck and Cover and other after-school specials.
- ^ "Futurama no. 3ACV15, J-Lo Dolly"
- ^ "BroadcastWatch (prime time television ratings, week of May 7-13)". Broadcasting & Cable (Reed Business Information). 2001-05-21. Retrieved 2009-03-07.
External links[edit]
|Wikiquote has quotations related to: I Dated a Robot


text:
Photo: This Modern Life
Wedding Invitation of the Day: Whimsical Carnival
Centerpiece of the Day:Proteas, Dahlias, and Flax Grasses
© 2015 Condé Nast. All rights reserved
Use of this site constitutes acceptance of our User Agreement (effective 1/2/2014) and Privacy Policy (effective 1/2/2014).
Your California Privacy Rights
The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of Condé Nast.


text:
Everybody nowadays is talking about surgical TV advertising, specially about the one launched recently concering cosmetic surgery by Optical Express.
The advertisement – a 30 second television ad – features a series of women in their daily routines; shopping, swimming, and sitting down for drinks with friends. The theme is body confidence and feeling good about yourself which is the message the company wants to promote with regards to its cosmetic surgery brand, " The Cosmetic Clinic". and which fits with the motto of the clinic: Your body, your choice.The Cosmetic Clinic is at Bridgewater Hospital in Manchester and it offers a full range of procedures, from breast enlargement, reduction and uplift, to liposuction, tummy tucks, and rhinoplasty. Though the current advertisement targets women, The Cosmetic Clinic offers procedures for both men and women. All surgeons are on the Specialist Register of the General Medical Council, and FRCS (Plas) accredited, to ensure the highest quality of care. This is the first cosmetic surgery television advertising campaign launched by Optical Express, but we are sure you will see plenty of these tv ads in the near future.
Return from cosmetic surgery tv advertising to home page.
Back to make a web page
A- Z site map.
Links to popular pages here.


text:
The Memphis Belle: A Story of a Flying Fortress (1944)
This film is a war documentary produced by one of the "Hollywood Colonels," William Wyler, who joined the Air Force Film unit and recorded the sights and sounds of the last mission of a B-17 bomber known as the Memphis Belle, named after the girlfriend of the pilot.
To Download or Embed this video, go to this link.
Back to the Documentary Films Library
back to Uncle Earl's Classic TV Channel


text:
Fabric mosaic created from quilting cotton; no stitching or paint applied.
Please view my youtube video at: http://www.youtube.com/user/RemnantWorks?feature=mhum#p/a/u/0/7JMPFSc3kOU
10% of all Imagekind print sales will be donated to Japan relief efforts.
© 2015 F+W All rights reserved.Use of this site signifies your agreement to the Terms and Privacy Policy, updated March 2007


text:
2014 Fantasy Football Quarterback Rankings – Week 11
With another exciting week of football under our belts, here are the Lester's Legends 2014 Week 11 fantasy football quarterback rankings.
1. Peyton Manning, Denver Broncos
Peyton Manning is averaging 323.6 yards and 3.2 touchdowns per game. He has thrown multiple touchdowns in every game. That streak should continue against the St. Louis Rams.
2. Andrew Luck, Indianapolis Colts
Andrew Luck is averaging 342.8 yards and 2.9 touchdowns per game with his arm and 14.3 yards and 0.2 touchdowns per game with his feet. He has had multiple touchdowns in every game this year. Luck faces the New England Patriots. The Pats have allowed 1.8 touchdown passes per game.
3. Tom Brady, New England Patriots
Tom Brady is averaging 320.2 yards and 3.6 touchdown passes in his past five games. After facing Peyton, Brady takes on his replacement. The Colts have allowed 263.6 yards and 1.8 touchdown passes per game.
4. Aaron Rodgers, Green Bay Packers
Aaron Rodgers is averaging 267.4 yards and 2.8 touchdowns per game. The Philadelphia Eagles will put up a fight so expect Rodgers to actually play a full game. Rodgers has 20 touchdown passes in the last six games. The Eagles have allowed 251.7 yards and 2.1 touchdowns per game.
5. Drew Brees, New Orleans Saints
Drew Brees is averaging 312.9 yards and a pair of touchdowns per game. He faces the Cincinnati Bengals at home. Brees is averaging 316.8 yards and 2.5 touchdowns per game at home.
6. Matthew Stafford, Detroit Lions
Matthew Stafford is averaging 277.3 yards per game and 1.4 touchdowns per game on the year. In his past three games he's averaging 301.3 yards and a pair of touchdowns. Calvin Johnson has returned to make Stafford more deadly. He faces the Arizona Cardinals. The Cardinals have allowed 274.2 passing yards per game.
7. Ben Roethlisberger, Pittsburgh Steelers
Ben Roethlisberger is averaging 306.3 yards and 2.3 touchdowns per game. He's averaging 401.7 yards and 4.3 touchdowns in his past three games. He should stay hot against the Tennessee Titans.
8. Philip Rivers, San Diego Chargers
Philip Rivers is averaging 261.2 yards and 2.2 touchdown passes per game. He threw for 313 yards and three touchdowns in his first meeting with the Oakland Raiders. Expect similar results coming out of his bye. Oakland has allowed 241.6 yards and 1.9 touchdowns per game.
9. Mark Sanchez, Philadelphia Eagles
Mark Sanchez threw for 332 yards and a pair of touchdowns taking over for Nick Foles. The Eagles offense is humming. Sanchez is a solid play against the Packers.
10. Matt Ryan, Atlanta Falcons
Matt Ryan is averaging 280.6 yards and 1.8 touchdowns per game. He's facing the Carolina Panthers. Ryan averaged 249.5 yards and 1.5 touchdowns against them last year. The Panthers have allowed 254.4 yards and 1.9 touchdowns per game.
The Next Batch
11. Russell Wilson, Seattle Seahawks at Kansas City Chiefs
12. Cam Newton, Carolina Panthers vs. Atlanta Falcons
13. Jay Cutler, Chicago Bears vs. Minnesota Vikings
14. Robert Griffin III, Washington Redskins vs. Tampa Bay Buccaneers
15. Colin Kaepernick, San Francisco 49ers at New York Giants
16. Eli Manning, New York Giants vs. San Francisco 49ers
17. Ryan Tannehill, Miami Dolphins vs. Buffalo Bills
18. Josh McCown, Tampa Bay Buccaneers at Washington Redskins
19. Andy Dalton, Cincinnati Bengals at New Orleans Saints
20. Shaun Hill, St. Louis Rams vs. Denver Broncos
Also check out:
- 2014 Week 11 Fantasy Football Running Back Rankings
- 2014 Week 11 Fantasy Football Wide Receiver Rankings
- 2014 Week 11 Fantasy Football Tight End Rankings
- 2014 Week 11 Fantasy Football Kicker Rankings
- 2014 Week 11 Fantasy Football Team Defense Rankings
- 2014 Week 11 Fantasy Football Sleepers
- 2014 Week 11 Fantasy Football Start/Sit
- 2014 Week 11 Fantasy Football Waiver Wire Advice
- 2014 Week 11 NFL Picks


text: MNDOT, YouTube [ Three Minnesota Highways Get A Speed Limit Boost By Mark Alan October 22, 2013 It's three state highways that gets a speed limit bump from 55 to 60 in Minnesota. Read More Category: Travel Tags: MNDOT Send to a friend! Share on Facebook Share on Twitter Pin it! Reddit This! Share on Tumblr!


text:
Veterinary Anaesthesia and Analgesia
© Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia
Edited By: Shannon Axiak and Cynthia Trim
Impact Factor: 1.72
ISI Journal Citation Reports © Ranking: 2014: 25/133 (Veterinary Sciences)
Online ISSN: 1467-2995
Recently Published Issues
Current Issue:September 2015
Volume 42, Issue 5
Volume 42, Issue 4
Volume 42, Issue 3
Volume 42, Issue 2
Volume 42, Issue 1
Most Accessed and Most Cited Articles
Read the top 5 most accessed articles in 2013 to date
Read the top 5 most cited articles published in 2012 and 2013 to date
Writing for Publication in Veterinary Medicine
This booklet will help residents, graduate students, and early-career faculty in veterinary medicine to write and publish scientific articles.
View Writing for Publication in Veterinary Medicine FREE online!
Editor's Choice
Selected key papers. Each issue. Free.
September 2015
Reversal of neuromuscular block in companion animals
Ronald S Jones, Ulrike Auer and Martina Mosing
Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane
Soile AE Pakkanen, Marja R Raekallio, Anna K Mykkänen, Kati M Salla, Annemarie de Vries, Lauri Vuorilehto, Mika Scheinin and Outi M Vainio
July 2015
Indexing cardiovascular and respiratory variables: allometric scaling principles
Bruno H Pypendop and James H Jones
Cardiovascular tolerance of intravenous lidocaine in broiler chickens (Gallus gallus domesticus) anesthetized with isoflurane
João Brandão, Anderson F da Cunha, Bruno Pypendop, Rhett Stout, Javier Nevarez and Thomas N Tully Jr
Read more Editor's Choice papers for free here.
Free access: Online Articles
Jump to the Online Articles in the November issue of Veterinary Anaesthesia and Analgesia., Volume 40, Issue 6.
These papers can be accessed online for free.
Sign Up To New Content Alerts
Register with Wiley Online Library, validate your email address and then login. Existing registrants need to login. Select 'Get New Content Alerts' on the top left under 'Journal Tools'. The Veterinary Anaesthesia and Analgesia alert will then be added to your account.


text:
London Pass BlogBack to Blog
Things to do in London: Tottenham Carnival
Published: Wednesday 16th of June 2010
Visitors making their way to London attractions like the Churchill Museum and Cabinet War Rooms or simply enjoying the day out with City Cruises can attend the Tottenham Carnival over the weekend.
This year's parade kicks off from Eade Road at 11:00 BST on Saturday (June 19th) and will make its way down to the Bruce Castle Park for the final festival celebrations.
The carnival is packed with events with something to cater to the tastes and preferences of all visitors.
People attending the carnival can enjoy themselves at the funfair or shake a leg to boombox beats. Youngsters can entertain themselves in the youth zone or the Spur Zone launched by the Tottenham Hotspur Football Club.
Provisions have been put in place to make the festival activities accessible and inclusive, promising all Londoners an exciting cultural experience.
Visitors might also add the Taste of London 2010 restaurant festival to their list of things to do in the capital, which will see 40 city eateries come together to offer foodies a gourmet experience.
Save time and money sightseeing in London with free entry to top attractions in London.
Posted by Kevin Smith
Related articles
Follow The London Pass blog to learn about the latest news with attractions, sights and sightseeing events in the city. As well as useful tips, hints and advice for visitors to the city and how to make the most of your sightseeing time in London. We hope you enjoy…
Prev 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Next
Treat the tastebuds at London attractions
Thursday 20th of December 2012 Things to do in London don't get much tastier than visiting some of the capital's greatest...
London attractions: The London Transport Museum gives people a glimpse behind the scenes
Wednesday 19th of December 2012 People who have always had an interest in transport services are well catered to in London
Things to do in London: The Jewel Tower is one of the capital's hidden gems
Tuesday 18th of December 2012 The Jewel Tower is a delight for people who are into history or architecture.
Visit Apsley House, the home of the Iron Duke, for things to do in London
Monday 17th of December 2012 People looking for things to do in London could opt for a trip to Apsley House, at one of the premier addresses in London.
London attractions: Take a Twickenham Rugby Museum & Stadium Tour
Sunday 16th of December 2012 A Twickenham Rugby Museum & Stadium Tour allows sports fans a behind-the-scenes glimpse at the sport.
London attractions: Relax with some delicious food at the Orangery
Saturday 15th of December 2012 The Orangery offers visitors an elegant lunch.
London attractions: Celebrate the Queen at Windsor Castle
Friday 14th of December 2012 People looking for London attractions that will give them a glimpse into the life of Her Majesty should consider a trip to Windsor Castle.
London attractions: Celebrate Olde England at the Fan Museum
Thursday 13th of December 2012 The Fan Museum is hosting an exhibition to mark the Queen's Diamond Jubilee year.
London attractions: See the evolution of aviation at the Royal Air Force Museum
Wednesday 12th of December 2012 The Royal Air Force Museum has plenty of highlights for aviation fans.
Get lost in the art of the Courtauld Gallery for things to do in London
Tuesday 11th of December 2012 The Courtauld Gallery is one of the best London attractions for art lovers.
London attractions: See how the children of the past played at Pollock's Toy Museum
Monday 10th of December 2012 Pollock's Toy Museum gives people a glimpse into the lives of the children of yesteryear.
Prev 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 Next


text:
Now, fring has announced what it's calling the world's first publicly available mobile VoIP app for the iPhone – albeit an unofficial one which requires a jailbroken or otherwise hacked "open" handset. That said, the company does adhere to Apple's guidelines by using Wi-Fi for calls and is labeling this a "light, sneak preview R&D version," so an official version is still expected in a couple of months when Apple opens up to 3rd party apps.
This is certainly great news for all iPhone users out there, as fring offers some nice features including both VoIP and instant messaging through fring, Skype, MSN, Google Talk, ICQ, Twitter, Yahoo! and AIM. You can download fring here (assuming you have a jailbroken iPhone and installer.app installed), or watch a video demo here.


text:
Black Eyed Peas to Perform at Super Bowl XLV Halftime Show
Entertainment Nov. 26, 2010 AT 12:01PM
The Black Eyed Peas will headline the Bridgestone Super Bowl XLV Halftime Show on February 6, 2011. The announcement was made on FOX Thursday during the New Orleans Saints at Dallas Cowboys game.
PHOTOS: Celebs' Super Bowl PDA
The Grammy Award-winning group, which includes Fergie, 35, will.i.am, 35, Taboo, 35, and apl.de.ap, 35, will perform at the Cowboys Stadium in Arlington, Texas.
Previous Super Bowl performers include Janet Jackson, The Who, Prince, the Rolling Stones, Paul McCartney, U2 and Aerosmith.


text:
Brochure | June 10, 2013
TORNADO® Surface Aspirating Aerator BrochureSource: RWL Water
TORNADO provides high oxygen transfer and intensive mixing capabilities.
The TORNADO aerator's turbulent directional mixing and jet propulsion discharge assures that oxygen is quickly blended with the wastewater for unmatched oxygen transfer. The intense action of the jet propulsion shears wastewater solids to increase treatment performance and provide better contact for the oxygen and wastewater bacteria.
RWL Water
MORE FROM RWL Water
Contact Details
RWL Water
767 Fifth Avenue, Suite 4200
New York, NY 10153
New York, NY 10153
212 572 5700


text:
Welcome to The Pipeline, Engadget's weekly roundup of the latest comments from the major tech and gadget pundits. This week, we check out Walt Mossberg's review of two ultralight laptops, David Pogue on binoc-cams, Stephen Wildstrom on the PSP, David Kirkpatrick on iPods, and more.
But first, we bid a fond farewell to The New York Times' Circuits section, which ran for the last time this week. Circuits began during the heady days of the dot-com boom, and managed to survive the bursting of the bubble, only to see its end come amid continued competition in the technology and consumer electronics space from magazines and web sites (er, sorry, guys), as well as a shift in direction by the paper's management (according to a leaked memo, Circuits will be replaced by a new section focusing "fashion, fitness, beauty, smart shopping and lifestyles"). Though columnist David Pogue will continue to ruminate in the paper's Business pages, and gaming articles will run in the Weekend section, we'll lose the "How It Works" feature, with its great cutaway pics of hot products; the "Online Diary," which ran links to off-the-beaten-path sites (and this week, fittingly, did a "where are they now" piece on some net pioneers); and the other features that made staggering out in our bathrobe on Thursday morning to grab the paper a worthwhile experience. Now we have one more reason to sleep in ... and to get our tech news online instead of in print.
In his last regular Circuits column, David Pogue checks out a handful of binoculars that have built-in digital cameras. Not surprisingly, even the best among them took mediocre pics, given their low megapixel count, inevitable camera shake and huge distance they're expected to cover. But, as Pogue points out, if you're the target customer for these — a bird-watcher (or maybe a trainspotter?) — image quality matters less than just the sheer ability to capture what you're seeing in real-time. Note: This is one column you'll want to read online, just to check out Pogue's loony bird-watching video. Let's hope he keeps this stuff up when he's over at the Business section.
Walt Mossberg this week returned to one of his — and our — favorite subjects: ultralight laptops. His two hot boxes this time around: the Sony Vaio T250 and the Fujitsu LifeBook P7010 (pictured at left). Both are just over three pounds, have great battery life, and have built-in DVD burners. At about $2,000 each, these won't replace a Presario or iBook as a workhorse machine, but for frequent travelers with expense account cash (i.e., readers of Mossberg's WSJ column), these are the new briefcase Bimmers.
If you're a regular visitor to Engadget, you'll recall that this was the week that an Australian school banned iPods, saying they created "social isolation." Meanwhile, Fortune's David Kirkpatrick mused on the iPod phenomenon, declaring that a little isolation isn't necessarily such a bad thing: "Why do I, and so many others, want to cocoon ourselves off into our little music bubbles, even when we're out and about? I think one reason has to do our exasperation with the other technologies around us: cellphones, PCs, BlackBerries, laptops, etc. ... I'm getting shell-shocked by technology. But now a new technology offers me an antidote: the iPod shuffle. And so my music-enveloped cocoon grows tighter. Music soothes the frazzled beast. My blood pressure drops." Hmm; wonder if we can get our health insurance to cover a Shuffle.
Kirkpatrick also commented on the fact that the music industry is missing the boat completely by failing to notice that iPods and other portable audio players are actually creating a bigger potential market, because people are listening to more music, as they wrap themselves tighter in their white plastic cocoons. The music industry was also on the mind of USA Today's Andrew Kantor, who used the PyMusique-iTunes battle as a jumping off point to argue that restrictive DRM policies are driving music lovers away from legit services and into the arms of pirates: "Imagine buying a music CD at the mall, bringing it home, and playing it on your stereo. Then you play it on your car's CD player driving to work. But when you get there and pop it into the little player on your desk, you hear a voice say, 'We're sorry, but you are only authorized to play this disk on up to two CD players. You have now exceeded that. Thank you.' That's exactly how iTunes and most of the other legal online music service work. When you pay for and download a song, it comes with various built-in restrictions. ... And people wonder why music piracy is so rampant." Kantor states that, until the music industry ends its "empty-headed, heavy-handed approach to business," consumers will "continue to get the shaft," and piracy will thrive.
Finally, the latest PlayStation Portable review from the business press. BusinessWeek's Stephen Wildstrom joined the growing consensus lauding the PSP for its game-playing capabilities and trashing it for everything else. Wildstrom takes particular aim at Sony's long-held policy of adding proprietary technology to every product they sell, rather than just sticking with proven standards: "The PSP supports only MP3 and Sony's own ATRAC formats, so the only purchased music you can play is songs from Sony's Connect music service. Even then, purchased music must be stored on a special type of Memory Stick — another Sony design — that includes Sony's MagicGate copy protection." Wildstrom also hits Sony's UMD-format videodiscs, and poor WiFi implementation. He does, however, offer a way out: "Standards rather than proprietary technologies are growing more and more important in a networked world. A continuing insistence on doing everything the Sony way leads only to isolation." Are you listening, Sir Howard?The New York Times - Circuits
David Pogue: Sizing Up a New Species: Camera-Binoculars
Walt Mossberg: Two Ultralight Laptops Offer Lots of Features, Improved Portability
David Kirkpatrick: iPods Make the World Go Away
Andrew Kantor: Hard to lower pirate flag while legal alternatives still lacking
Stephen Wildstrom: The PlayStation Portable Has Miles To Go


text:
Students anywhere are being offered free instruction online. What will that do to the trillion-dollar education business?
Scooped by
Mohsen Saadatmand
onto Open Ed, MOOCs, OER
Get Started for FREE
Sign up with Facebook Sign up with Twitter
I don't have a Facebook or a Twitter account
Your new post is loading...
Your new post is loading...
Susanna Sancassani's curator insight, May 19, 2014 3:36 AM
Is it possible to blend cMOOCs and xMOOCs approach? George Siemens says no, but it is possible to create synergies between different parallel layers...I think that real paths of real students could be something more complexe than we can imagine: if they are allowed to do it, perhaps they will mix the two layers in very personal and different ways in continuous evolution during the learning experience...what do you think about it?
KCenter SKEMA's curator insight, May 20, 2014 12:30 PM
"the difference between xMOOCs & cMOOCs and possible ways to blend them.
The interest in making xMOOCs more like cMOOCs (a few silly folks have called it MOOC 2.0 – haha) seems to be growing. In particular, MOOC providers are adding "social" in the same way that vitamins are added to food, "Now, with beta-carotene"! After much discussion at our designjam, I've concluded that cMOOCs and xMOOCs are incompatible. They cannot be blended. Pedagogically and philosophically, they are too different. It's like trying to make a cat a dog. Entertaining, perhaps, but a fruitless venture."
Annarita Bergianti's comment, May 21, 2013 5:22 AM
Annarita: MOOC per docenti che vogliono imparare l'utilizzo di nuove tecnologie per l'educazione
Susanna Sancassani's curator insight, May 19, 2014 2:50 AM
By Fiona M. Hollands and Devayani Tirthali (Center for Benefit-Cost Studies of Education Teachers College, Columbia University) a 200 pages report about state of art and perspectives of MOOCs: enjoy it!
Gina Anderson CEO Mopi16 's curator insight, May 13, 2013 8:19 AM
We are going to see research in the next 3-5 years coming in about the beneficts and challenges of MOOC's. Interesting to me are the business models. Great marketing tool for those who have a current base of clients.
Peter B. Sloep's curator insight, June 6, 2013 2:34 AM
I have little to add to this other than that the collection of papers provides a distinctive European perspective on MOOCs. As a consequence (?), the focus is more on the pedagogy than on the economics of higher education (@pbsloep)


text:
- Home
- News
- Sports
- Opinion
- Obituaries
- Features
- Special Sections
- Classifieds
- Public Notices
Forgot Password? | Not a User? Sign up
The Los Alamos Hilltopper girls basketball team made a big third quarter stand and hit shots down the stretch when it needed to, picking up a key win Saturday.
Los Alamos held the Grants Pirates to four points and one field goal in the third quarter, slowing to a crawl what had been an efficient offensive attack in the first half to win 55-48 at Griffith Gymnasium.
Kiana Zerr posted her best performance of the season, scoring 14 points and hitting eight straight free throws at one stretch to aid Hayley Each, who had another big night for the Hilltoppers (5-5).
Each scored 17 points in the first half and 25 for the contest. She hit all four of her free throw attempts in the final quarter, including both ends of a key 1-and-1 chance to help seal the victory.
Saturday's win came on the heels of a 44-37 loss Friday night to Piedra Vista.
For Grants (6-3), Sydney Mares had 17 points and Haley Hall had 13. However, the Pirates were held to just two field goals in the second half, although did go 26 of 41 from the foul line.
If you currently subscribe or have subscribed in the past to the Los Alamos Monitor, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
If you are new to the award winning Los Alamos Monitor and wish to get a subscription or simply gain access to our online content then please enter your ZIP code below and continue to setup your account.
|ZIP Code:


text:
Separate names with a comma.
Great responses and I think I am starting to get a warm and fuzzy about being able to drop on engine in vert and not fear for my life. To help...
Ok I'll PM you my address where you can send the cash :D
What do you consider too much power for the street? I'm currently working on a weekend warrior but don't want it to get out of hand with the...
I'll PM the VIN if so.
I love my tranny and my shifter too much and my tires. A street driven Stang? Wow! To each his own.
:jaw: Why the hell?
Hey check out my group Mustang Talk and Tech and I'll let you join. It's a private to keep advertisers, ricers, and bad mouthers out.
Lots of red "X"s in this thread so I wanted to see if Stangers wanted to update their pics or change the URLs to reflect what's missing. Also...
Whoa! It puts the lotion on it's skin! Is that Lurch?
That's the best way for me to keep up with my friends. I use it more than Yahoo messenger.
I feel you on that but I feel the most for people that don't their questions answered because they are noobs.
Ok having seen that I can finally say i'm ready to go to bed. I can sleep in full confidence that that pic will be haunting me in my dreams.
Man I'm rolling here :rlaugh: You guys are to much. :rlaugh:
What's the URL to your page? If you don't wanna suffer the same fate as me from the troll who posted my pic up above then you can send me a...
Vib couldn't hook you up?
I think with all the negative posting going on it actually gave fuel to the justification of having it in the first place. Oh irony how you mock...


text:
Posted: Saturday, May 14, 2011 10:41 AM
Let me Emphasize that I am about Corporal Punishment with Adults. I spank slap,paddle,strap,cane,and whip. I do not have any sort of SEX with any of my visitors. There will be no Sexual Contact between us nor will you be permitted to self induldge. I have a certain policies and procedures during my application process. Email me and allow 24 to 48 hrs for a response.
• Location: hampton roads area, Northern Virginia
• Post ID: 5033660 washingtondc


text:
2nd pregnancy stretch mark question...
I am wondering this too. I only got two stretch marks with my daughter 7 years ago and so far none with this one. Hmmm...I guess we shall see.
DD (ECS) Rylinn - September 28th, 2005
DS (RCS) Jensen - April 15th, 2013
DD (RCS) - April 16th, 2014!!!
With my first pregnancy I started getting them at 22 weeks, before gaining a single pound!
So far, I haven't added any new ones that I've noticed, and the old ones haven't really changed. I think just wherever your skin gets the most pressure is where any new ones are going to show up.
Proud mommy to PRINCESS CONSUELA BANANA HAMMOCK, 4 weeks early on 8/14/10.
L's Baby Brother, 2 weeks early on 3/28/13!
1 sweet little girl - 7/19/2011
Identical twin boys - 3/29/2013
Carrie&Patrick [est.07.11.07]{married12.05.10}
Caleb Ethan [09.07.10]
Ella Josephine [edd. 04.21.13]
Jenn~22 & Elton~23
Amalia(Lea)~ June 27, 2011
Annabelle(bean)~ May 1, 2013 Bronze beewbs (o)(o) going for gold


text:
Price: $49.95
Product ID : LACWS8117UITOAK
Manufacturer: La Crosse
Milwaukee: In stock
Orlando: In stock
Cleveland: In stock
Las Vegas: In stock
E-mail to a friend
Please complete this form.
All fields are required.
Item Description
Digital Atomic Wall Clock
Detailed Description
Shows 12/24-hour time, a perpetual calender, indoor temperature and outdoor temperature via a remote sensor up to 82 ft. away. Clock sets automatically via WWVB, has 13 time zone settings, daylight saving time and 8 moon phase icons. Alarm with snooze. Wall mount or free standing. Requires (4) "AA" alkaline batteries. Oak finish. Dim: 12.2"w x 8"h x 1.18"d.
Products You May Like
Price: $24.95
La Crosse WS-9004U-IT
Price: $29.95
La Crosse WT-8005UB
Price: $29.95
Davis 0281
Price: $29.95
Velleman MP-25SFM
Price: $49.95
Price: $29.95


text:
Hearts striker Fiamenyo to undergo surgery this week
Gilbert Fiamenyo will undergo surgery on his troublesome ankle by the close of the week.
The 22-year-old has not kicked a ball for Hearts this season and was hoping to be involved at some point.
Scans have revealed that the problem in the knee has not completely healed and will need a surgery to correct the torn ligament.
Funds have been made available for team doctors to proceed with the operation.
"We are all set for surgery and hopefully it should be done before the close of this week,' a member of the medical team is quoted by 90 Minutes newspaper.
"We will reposition part of the broken bones and repair some ligament."
The former Heart of Lions man is expected to fully recuperate in February, 2013


text:
Boye Steel Crochet Hook Set of 6
Featuring rounded-yet-precise heads and smooth throats, these tempered steel hooks won't split strands or bend under pressure - the perfect tool for fast and uniform crocheting. Set of 6 hooks in US sizes 0, 1, 7 8, 9 and 10 (3.25mm, 2.75mm, 1.65mm, 1.50mm, 1.40mm and 1.30mm).
| Steel Crochet Hooks
Retail: $9.99 Item No. 81626


text:
Don't throw those faded, holey old towels out. Besides being excellent cleaning rags, spew rags (which I just realised yesterday that I needed a whole heap of with my sick little boy), wiping the wet dog rags, they can be made in to many other useful things for around the house. Check out these ideas from Pinterest.
Saturday, August 4, 2012
24 uses for old towels
Don't throw those faded, holey old towels out. Besides being excellent cleaning rags, spew rags (which I just realised yesterday that I needed a whole heap of with my sick little boy), wiping the wet dog rags, they can be made in to many other useful things for around the house. Check out these ideas from Pinterest.
19 comments:
like like like like....and oh my lord, can someone make me one of those kitties?ReplyDelete
I saw a squirrel statue yesterday and wanted to send it to you. It was unnaturally heavy though. :(ReplyDelete
I love those ideas! Some of my washcloths are starting to fray around the edges so I should add a binding like that!ReplyDelete
Fabulous list!ReplyDelete
Love these lists - a towel beach bag is def on my learn to sew list and maybe I'll get around to it one of these days, lol :) Have a great weekend!ReplyDelete
Ha! We needed the vomit rags this week, but I was using whole towels for huge boys! I'm always cutting them down to make floor cloths, hand things old towels though, some of those ideas are amazing.ReplyDelete
Wow what great inspiration for old towels! I've used them for rags, make great ones, but these ideas are beyond anything I could come up with. So many I could do, what a fabulous list! My fingers are crossed you'll share your creative inspiration tonight with Sunday's Best – sharing is a good thing! These are ideas need to be shared!ReplyDelete
I love these ideas! I have a bag of old towels that I am in the process of turning into floor mats.ReplyDelete
Thanks for linking up to Totally Pinworthy!
Amy x
So many great ideas, I plan on trying many of them. Thanks for sharing!ReplyDelete
~ Terrie, your new follower.
Anne, as always you have found some treasures! I never would have though to make wash cloths from old towels or those kittens...cute! :DReplyDelete
I was just about to get rid of a few towels! Perfect timing...ReplyDelete
Just wanted to invite you to join my Tasteful Tuesday Party. I have been hosting a recipe party (pretty successfully!!!) for over a year now, and this week we are opening up for crafts, DIY and home decor. Hope you can come by and check it out! http://www.nap-timecreations.com/2012/08/fresh-pesto-pasta-salad-and-tasteful.html
I am so inspired! Wow what fabulous ideas on how to recycle old towels! Come link up to Centerpiece Wednesday and share your ideas with us!ReplyDelete
What great ideas! I especially like the beach bag and beach mat since we have a vacation coming up!ReplyDelete
Wow! Those are really great ideas! :)ReplyDelete
so clever! Thanks for linking to the first every craft link at Tasteful Tuesdays! Hope you come back again this week and show off your stuff! Party Opens tonight at 8:30. http://www.nap-timecreations.comReplyDelete
Amazing post !!! So many new projects and gives me a reason to finally get more new towels lolReplyDelete
New follower here
Xo Adriana
What great ideas! Thanks so much for the inspiration!ReplyDelete
Melissa @ The Alchemist
Wow, you are so talented to be able to create all of these projects with the old towels! Very resourceful!!ReplyDelete
Amy @ Creative Kid Snacks
WR Spa - Pijat dan Spa Panggilan 24 Jam JakartaReplyDelete
Spa Panggilan Jakarta Paket Jasa Spa & Massage Jakarta Panggilan 24 Jam. Bisa Dipanggil Ke Rumah, Apartemen, Hotel dan Kost! Cek! SPA/Massage Jakarta Panggilan Khusus Pria dan wanita dengan Tenaga Kerja Muda, Trampil dan Profesional. Hub. Massage Jakarta Panggilan terMurah tapi tidak Murahan! WR Spa - Pijat dan Spa Panggilan 24 Jam Jakarta


text:
USC looking for confidence lift against Alabama
Darrin Horn said his South Carolina squad is out of excuses.
At two games below .500 overall and winless in the SEC in late January, it's simply time for his players to start making some plays if they want to get that first conference victory.
He hopes they'll have a chance today at 8 p.m. when USC (8-10, 0-4 SEC) hosts Alabama (13-6, 2-3) on the SEC Network.
"We've got to find a way to keep getting better and we've got to find a way to get a win," Horn said. "We've got to keep plugging and moving forward and (today) is important for that."
Confidence after losses isn't the Gamecocks' problem; it's during games.
Horn said his team bounced back from last Saturday's 63-52 loss at Auburn with a good attitude this week, but during a second-half shooting slump combined with a Tiger run Saturday, sophomore forward Damontre Harris said he said to himself, "Here we go again."
"When those things start to happen, confidence obviously becomes an issue, but we have to understand some of that gets corrected by playing better, by doing the basketball things you need to so you don't get yourself in those situations as much," Horn said. "We can feel sorry for ourselves and whimper and whine or we can get back to work."
Against Auburn, the Gamecocks turned the ball over 23 times — and many of them were unforced errors. Horn hopes that's not a trend after spending much of the earlier part of the season working to end those frustrations.
"You turn the ball over 23 times in a game, you've got to do some other stuff like amazingly well. That's true in every sport," Horn said. "That part is frustrating because we feel like we've made some strides in that area. When you have that one glaring area it makes it nearly impossible to win in that particular game."
Alabama presents a whole new set of issues. The Crimson Tide lead the league in scoring defense, allowing just 57.5 points per game.
"We've got to find a way to get some easy ones in transition or maybe on the offensive glass," Horn said. "They're extremely effective when their defense is set in the halfcourt. They're very big and physical. That's something that will be important in the game."
USC's defense ranks fourth in the league while its scoring offense is 11th at 63.3 points per game, so points could come at a premium today.
"They've done a really good job of mixing up their defense to create turnovers and transition opportunities," Tide coach Anthony Grant said. "Also, they're a great rebounding team."
Alabama isn't much better offensively with an average of 66.6 points per contest. Three Tide players are averaging double figures in scoring with senior forward JaMychal Green leading the team at 14.2 points per game.
USC counters with just two players averaging double digits in points. Senior forward Malik Cooke putting up 12.2 points per contest while sophomore guard Bruce Ellington is averaging 10.9.
Alabama, which is coming off a 77-71 loss at No. 1 Kentucky, has won three consecutive meetings against USC and six of the last 10, but the Crimson Tide is just 2-4 on the road this year.
Horn's just hoping his team will finally be in position late in a game.
"What we've got to do is get to the 5-minute mark with a possession game one way or the other," he said. "We haven't given ourselves that chance yet. Actually, that's the first step in having a chance to get one."
Subscribe to the Independent Mail
Need Help? Call us at 1-864-260-1284.
Monday-Friday: 6am-4:30pm / Saturday: 7am-11am / Sunday: 7am-2pm


text:
Holy smokes! We closed our space at 412 Broadway on June 30. Learn more!
No one should have to feel like they're on their own! There are communities of people all over New York City who are gathering to share space and help each other. We are here to help you find your people.
Regsiter for our fab newsletter
Photo credit: Lee Semel
All around New York City, communities are forming among people who want to connect with each other, so nobody has to go it alone. We're here to ensure anyone who works for themselves can find the people and the resources they need to thrive.
We aspire to make New York City the world's first "indie-friendly city." If you work for yourself and want to find your tribe of coworkers, we're here to help.
So, what next? We've got some options for you!
Our Coworking Community NYC Meetup Group is home to a community of people who connect online and work from various coworking spaces, cafes, and other spots throughout the city. If you're new to the city or just looking to connect, this is a great place to get started.
Wherever you are in the metropolitan area, chances are that there's an independently run, community-focused coworking community near you. Scroll down to see some of the featured communities that support our network!
We're here to help. We've been building coworking communities since 2008, and are dedicated to helping aspiring like-minded leaders to succeed. We've got tons of resources to make it easier for you to get started and avoid a lot of the pitfalls you might encounter. If you'd like to discuss, contact us at partnerships [at] nwc.co!


text:
Buchanan, William J, Fan, Lu, Thuemmler, Christoph, Lo, Owen and Ekonomou, Elias (2011) Cloud-based e-Health System. In: BCS Health Informatics, September 2011 , Edinburgh. (Unpublished)
Available under License Creative Commons Attribution Non-commercial.
Download (4MB) | Preview
This paper presents the future of health care system, which uses the newly developed security infrastructure.
|Item Type:
|Conference or Workshop Item (Paper)
|Uncontrolled Keywords:
|e-health care; cloud computing; security;
|University Divisions/Research Centres:
|Edinburgh Napier University, Institute for Informatics and Digital Innovation
|Dewey Decimal Subjects:
|000 Computer science, information & general works > 000 Computer science, knowledge & systems > 005 Computer programming, programs & data > 005.8 Data security
|Library of Congress Subjects:
|Q Science > QA Mathematics > QA75 Electronic computers. Computer science
|Item ID:
|Depositing User:
|Computing Research
|Date Deposited:
|03 Nov 2011 15:26
|Last Modified:
|03 Nov 2011 15:27
Actions (login required)
|View Item


text:
These conditions should be read in conjunction with the ticket conditions appearing on each ticket that apply to all ticket holders.
In this Article
Please note that the above Conditions of Entry may vary between events.
PUBLIC AREA : All Bays with the exception of Bay 102.
MEMBERS : All Bays with the exception of Bay 103
Alcohol is not permitted in the Standing Areas of the Stadium. It must be consumed in the allocated Seating Bays or in the Bar Areas,.
Patrons are also reminded when entering AAMI Stadium:
All patrons are stongly encouraged to seek assistance from Event or Security Staff should they encounter a problem with other patrons around them. Discretion will be used at all times when dealing with alcohol related issues in Seating areas.


text:
Defense contractor General Dynamics said April 25 its first-quarter net income fell 9 percent, below analysts' expectations. Earnings were hurt by cuts in government contracts and an accounting charge in its European combat systems operations.
General Dynamics, which makes jets, tanks and other military vehicles, said its aerospace revenue was strong ó up 20 percent during the quarter on demand for its Gulfstream jets. Other divisions were hit by a slowdown in U.S. defense spending.
Under a budget agreement that President Barack Obama and congressional Republicans reached last August, defense spending will be cut by $487 billion over the next decade.
"We are continuing to see slower-than-anticipated award activity," said CEO Jay L. Johnson, referring to government contracts.
Net income fell to $564 million, or $1.58 per share from $618 million, or $1.66 per share last year. Revenue fell 3 percent to $7.58 billion, from $7.8 billion.
Analysts polled by FactSet expected net income of $1.69 per share on revenue of $7.91 billion.
The Falls Church, Va.-based company said a $67 million accounting adjustment in its European operations reduced earnings by 13 cents per share.
General Dynamics expects net income of $7.10 to $7.20 per share in 2012. Analysts forecast $7.32 per share. AP


text:
This item is currently
Our Top Recommendations
Sunstone Grills Flush Single Access Vertical Door $149.99 - $169.99
Sunstone Grills Flush Double Access Doors $215.99 - $319.99
HN-WSU071 Napoleon
Napoleon Built-In Stainless Steel Zero Clearance LinerItem # HN-WSU071
Roll over to zoom
Click for full screen
- Talk to our Napoleon product specialists! Call 866-579-5183.
- Zero-clearance liner for Napoleon 600 series grills
- Insulate your grill to install in combustible materials
- 304 stainless steel construction contains heat
- Dimensions: 44.25W x 23D x 11.25H inches
Full Description
More From This Brand
Guarantee & Returns
Recommended Accessory
Similar Outdoor Kitchens
Bull Free Standing Outdoor Stainless Steel Refrigerator
Sunstone Grills Flush Single Access Vertical Door
$149.99 - $169.99
Sunstone Grills Flush Double Access Doors
$215.99 - $319.99
Sunstone Grills Double Access Flush Mount Doors with Vents
Napoleon Mirage BIM730RBI Built-in Grill with Infrared Searing Burner
Bull Angus 4 Burner Built-In Gas Grill
$1,697.00 - $1,954.00
Sponsored Links
Napoleon Built-In Stainless Steel Zero Clearance Liner
The product specialists at Hayneedle have been extensively trained by the manufacturer of Napoleon grills. These specialists know the product inside and out, top to bottom, front to back. They're here to help you with every step of your Napoleon grill purchasing process. Learn everything you need to know as you customize your grill island with drawers, doors, pizza ovens and more! Call 866-579-5183 to speak with a product specialist and start building your dream grill island today. Hour


text:
Instant "Members Only" Coupon Codes Emailed NOW When You Sign Up for FREE Membership!
You are already an existing user.
Do you want to opt back in?
Please check your email inbox for a confirmation message.
Just click the link to complete your subscription and receive your coupon codes.
Popular Destinations
- Mexico
- Caribbean
- Las Vegas
- Orlando
- Hawaii
- Florida
- New York City
- Costa Rica
- New Orleans
- San Francisco
Quality Inn & Suites New York Avenue
A stay at Quality Inn & Suites New York Avenue places you in the heart of Washington, convenient to U.S. National Arboretum and United States Capitol. This family-friendly hotel is within close proximity of Gallaudet University and Atlas Theater. Read More About Quality Inn & Suites New York Avenue
Quality Inn & Suites New York Avenue Deals & Specials
- 24-Hour Front Desk
- ATM Machine
- Business Center
- Complimentary Coffee
- Dry Cleaning Service
- Elevator / Lift
- Express Check-In
- Fitness Facility
- Free Breakfast
- Free Local Calls
- Laundry Services/Laundry Facility
- Multilingual Staff
(+) = Additional fees may apply for the use of these amenities.
(*) = Free, some restrictions may apply.


text:
Dartmouth's Daily Blog
News, commentary, criticism and praise for the College on the Hill, enlivened with history, culture and travel when we feel so moved.
Archived post
This is an archived post. Please click here to see the latest entries.
« Next Up, President Phil Hanlon | Home | The Whole World's Watching Us »
Another Chance to Help The Drive-In
Not long ago we ran the below post about a Kickstarter campaign to help the Fairlee Drive-In equip itself with a new digital projector. The effort did not quite get there, but Cooper Trapp and his family are giving it another shot. Here is their new Kickstarter page.
Drive-ins all over the country are facing the same problem, and Honda is helping out. Check out this short video that the car company has produced:
Assisting the Fairlee is a good cause. There is something right and good about being outside on a summer night in front of a movie screen. Give generously.
Save the Fairlee Drive-In
If you spend four years at Dartmouth and don't see at least one movie at the Fairlee Drive-In, you can't honestly say that you went to school in New Hampshire. Sitting in the warm grass watching a flick makes for a summer memory that one day will cause your children to look up from their iPhones in wonder. But only if the place survives.
The Fairlee is run on a shoestring by the Trapp family, and it seems that they don't have enough shoestrings to afford a $77,208 digital projector. The movie studios are phasing out 35mm film in order to save money, and theaters are converting to the new technology. The Fairlee has scared up $22,100 in donations so far; they still need another $55,108. Want to help? The drive-in has a campaign going on Kickstarter, which they are running for another week. Hurry.
Note: there are only two drive-ins in the country that have an adjacent motel. At the Fairlee you can watch movies from the comfort of your own room. What will they think of next?
For more information, you can reach Peter & Erika Trapp at 603-272-5008. Their e-mail address is: email@example.com, and they have a Facebook page.
Featured posts
August 14, 2013
Breaking: Of Crips and Bloods and Memories of Ghetto Parties
History repeats itself, first as tragedy and then as farce, or sometimes it just repeats itself. From the New York Times on November 30, 1998: At Dartmouth College, white students at a "ghetto party" dressed…
June 25, 2013
Dean of the College Charlotte Johnson's War on Students Part (2/2)
Part 1, Part 2 Today's post again recounts the events that befell the Freshman. However, the content of the Hanover Police department report reproduced in this space yesterday is supplemented by information from my own…
October 18, 2009
When Love Beckoned in 52nd Street
We were at San Francisco's BIX last evening, enjoying prosecco, cheese, and a bit of music. A full year of inhabitation in Northern California has unraveled to me no decent venue for proper lounging, but…
October 9, 2009
D Afraid of a Little Competish
So our colleague and Dartblog writer Joe Asch informed me that the D has rejected our cunning advertising campaign. Uh-oh. The Dartmouth is widely known as a breeding ground for instant New York Times successes,…
September 4, 2009
How Regents Should Reign
As Dartmouth alumni proceed through the legal hoops necessary to defuse a Board-packing plan—which put in unhappy desuetude an historic 1891 Agreement between alumni and the College guaranteeing a half-democratically-elected Board of Trustees—it strikes one…
August 29, 2009
Election Reform Study Committee
If you are an alum of the College on the Hill, you may have received a number of e-mails of late beseeching your input for a new arm of the College's Alumni Control Apparatus called…


text:
University of Missouri - Saint Louis
The Graduate School
An oral examination in defense of the dissertation for the degree
Doctor of Philosophy in Applied Mathematics
John Aleshunas
M.S. in Computer Science, May 1994, Missouri University of Science and Technology
B.S. in Mathematics, May 1975, Carnegie-Mellon University
GP Representation Space Reduction Using a Tiered Search Scheme
This investigation explores a technique to reduce the complexity of the representation space for genetic programming (GP) applications. The proposed methodology divides the GP search into two-tiers. The first tier conducts its search using a low granularity GP search technique that produces a probabilistic model of the representation space. This model is used to condition the second tier search. The second tier search uses a higher granularity technique. The combined search results in better solution fitness scores and lower computational time than standard GP applications. The size and complexity of a GP representation space is defined by the set of functions and terminals used, the arity of those functions, and the maximal depth of candidate solution trees in the space. Adaptable Constrained Genetic Programming (ACGP) can discover beneficial substructures and probabilistically bias the search to promote their use. ACGP has two operating modes: a low granularity mode (1st order heuristic mode) and a high granularity mode (2nd order heuristic mode). Both of these operating modes produce a probabilistic model of the representation space. These models identify the beneficial building blocks, and the combinations of these building blocks describe productive search regions in the GP representation space. The methodology described in this research uses a low granularity 1st order ACGP search in its first tier to produce a probabilistic model. This model is then used in the second tier to condition a high granularity 2nd order ACGP search. The computational basis for this technique is explained, and the empirical results from three problems are presented to demonstrate its efficacy. The two-tier GP search method improves the GP search by probabilistically reducing the representation space. This improvement is characterized by better solution fitness scores and a reduction in training time.
|Date:18 April 2013
Time: 11:00 a.m. to 12:30 p.m.
Place: 304 Express Scripts Hall
Cezary Z. Janikow, Ph.D. (Advisor)
Sanjiv Bhatia, Ph.D.
Uday Chakraborty, Ph.D.
Wenjie He, Ph.D.


text:
Double T Insider
The goal of Double T Insider is to create a positive opportunity for Texas Tech Media & Communication students, from undergrads to graduate students, to exercise their ability to perform a variety of skills with a focus on the various aspects of broadcasting. Through an entirely student based production team, students are given the chance to become experienced individuals with the ability to voice their ideas and produce their visions in a collective, free thought atmosphere. We are committed to the success, growth and expansion of on-campus opportunity with a focus on student ideas and professional excellence in order to become a leader of student organized programs.
Select either the picture of the episode or the date in order to view the video.
Spring 2013
Season Finale - 05/03/13
The final episode of Double T Insider Season One is here. We take a look back and bring you the best stories of the spring.
Episode 17 - 04/26/13
On this weeks show, Spring Football game recap, fans reaction to Kliff Kingsbury and their expectations for the upcoming season, Lady Raider tennis wins their second-straight Big 12 Championship, Kierra Powell learns how to long jump in Don't Sweat the Technique and Michael Brewer goes On the Clock with Erica Taylor.
Episode 16 - 04/19/13
This week we recap Friday Night Lights with Red Raider Football, give you another spring football report, Texas Tech baseball took on Lubbock Christian this past week, we have that story and Baron Batch was back in town showing off his art as well.
Episode 15 - 04/12/13
On this weeks show, Red Raider football spring report has another installment, a construction update from Jones AT&T Stadium, Red Raider soccer kicks off spring practice and track and field was at home for the first time this past weekend.
Episode 14 - 04/05/13
This week on the Double T Insider, Tubby Smith is introduced as the new head coach for Texas Tech men's basketball.
Episode 13 - 03/29/13
This week on the Double T Insider it was senior day for Lady Raider Tennis this past week, Tech football began spring practice, we wrap up the State of the Red Raider Nation with Kirby Hocutt and more.
Episode 12 - 03/22/13
This week on the show, the Lady Raiders are in the NCAA Tournament, we caught up with the team during the selection show.
Episode 11 - 03/15/13
This week is the mid-season "best of" episode for the Double T Insider where we bring you the best of the spring thus far.
Episode 10 - 03/08/13
Double T Insider is back with more inside access. This week we honor the seniors of Lady Raider basketball as they look back on their careers, Kirby Hocutt sits down with us in part two of the State of the Red Raider Nation segment and much more.
Episode 9 - 03/01/13
Double T Insider is back and this week Kirby Hocutt, Texas Tech Athletic Director, speaks to us in part one of four of our new segment, State of the Red Raider Nation. This week he is talking Kingsbury. Also Emily Bledsoe is heading to Italy to play professional softball and much more.
Episode 8 - 02/22/13
This week's episode of the Double T Insider reviews the 20-year reunion celebration of the 1993 Lady Raider basketball championship tittle. Also, hear what Tech fans have to say about opening day of the Red Raider baseball season.
Episode 7 - 02/15/13
Play Ball! Joshua Koch and Erica Taylor head out to the ballpark to get ready for baseball season and much more.
Episode 6 - 02/08/13
Another week of the Double T Insider is here. Kliff Kingsbury announces first recruiting class, go behind the scenes at Lady Raider basketball, and much more.
Episode 5 - 02/01/13
Chynna Brown has been lighting it up lately, JaCorian Duffield teaches us how to high jump and much more in this weeks episode.
Episode 4 - 01/25/13
On this weeks show, Kliff Kingsbury introduces staff, JaCorian Duffield keeps jumping higher and higher in 2013, Caroline Starck is entering her final season with Lady Raider tennis and much more.
Episode 3 - 01/18/13
New episode of Double T Insider is here, softball reports for practice, women's tennis preps for season and Katie Grimes breaks a school record.
Episode 2 - 01/11/13
Here is the newest edition of the Double T Insider. We spoke to long jumper Bryce Lamb in the player profile, Tech head women's basketball head coach Kristy Curry won her 300th career game, men's tennis head coach Tim Siegel joins us in the Coaches Corner, Chynna Brown tries to answer 10 questions in 60 seconds in our Full Timeout segment and we have a new Texas Tech Trivia question of the week, do you know the answer?
Episode 1 - 01/04/13
The Double T Insider is back for the spring season. Erica Taylor and Joshua Koch bring you an inside look into Texas Tech Athletics.


text:
Lego: Legends of Chima 2 Seasons 2013
Amazon Video
1. The Legend of CHIMA When Cragger the Crocodile is caught trying to steal CHI, the Lions call his parents, the King and Queen of the Crocodile tribe, resulting in misunderstandings that eventually develop into a full scale battle.
2. The Great Story When Cragger disrupts the racing games during the CHI day festivities and attack the Lion City with the wolves and the ravens, the lions must call upon the Eagles and Gorillas but they learn that sometimes peace can be restored in the most unexpected ?
3. The Warrior Within Cragger, under the influence of Crooler's magical flower, tricks Laval into withholding the crocodiles' share of CHI, thus inflaming hostilities between the Lion and Croc tribes yet again.
4. The Joy Ride When Cragger employs the beavers to build a dam that, when completed, will disrupt the flow of water from Mount Cavora, Laval must find a way to destroy the dam to restore the flow of the precious CHI water from Mt. Cavora.
5. Market Day It's market day and the CHI celebration race for the Golden CHI is on but when the Ravens steal the golden orb, it looks like the race might not happen at all.
6. Attack on Eagle Spire When Cragger attacks the Eagle Spires with the help of the Ravens, Laval and the Lions arrive to help the Eagles - but the Ravens realize that Cragger's plan might cause them to lose all their best customers and get second thoughts.
7. The Hundred Year Moon On the night of the 100 Year Moon where the Wolves are at their most primitive and through centuries have lost control, Cragger and Crooler kidnap G'loona to lure Laval and his friends out on a search mission, hoping to cross paths with the wild wolves.
8. The Biggest Race of all When the CHI celebration races for the golden CHI are on again, everybody wants to win but a new mysterious racer called "Shadow Wind" emerges during the races - who is he?
9. Gorillas Gone Wild When Cragger angers the peace-loving Gorillas, they march to attack the Crocodiles in the Croc Swamp with their big battle mechs - can they defeat the crocs in their own swamp?
10. Foxtrot When Crooler steals the Lions' share of CHI with the assistance of the Wolves, she pays them by throwing the ancient "Pledge of the Pack" into the Gorge of Eternal Depth but the mysterious Shadow Wind unexpectedly hands the document to the lions.
11. The CHI Jackers When the wolves start ambushing the other Tribes and steal their CHI, the balance of Chima starts to shift as all tribes - except for the wolves that grow increasingly powerful - begin to run out of CHI.
12. Balancing Act Earthquakes and thunder storms shake Chima as a result of the imbalance caused by the misappropriation of CHI and when the Eagles lose a supply of CHI into the Gorge of Eternal Depth, Laval, Eris and Gorzan attempt a dramatic recovery of the CHI.
13. Crocodile Tears When Cragger and his Croc troops attempt to steal back some of the CHI the Wolves have stolen from the other tribes, they are captured and taken prisoner - but Laval is determined to help is old friend Cragger and attempts a daring rescue.
14. Fake CHI, Real Trouble When Crooler loses control over Cragger, he reverts to his good, old self and is in high spirits, willing to help all animals of Chima - but as usual, Crooler has a trick up her sleeve and employs a Raven alchemist to produce fake CHI.
15. Ravens vs Eagles CHIMA is peaceful yet again. Laval and Cragger go on a joyful Speedor cruise. But the Ravens use the peace to move into Eagle Spires. The Eagles try to get rid of them, but the Ravens are very persistent. It will be up to Eris to trick them to leave.
16. Reunion Gone Wrong Laval and Cragger attempt to get all of the tribes to agree on a lasting peace in CHIMA. But Crooler creates a strange fog that makes everyone become very powerful and angry ... especially Cragger.
17. Laval in Exile Laval's actions to break up the fighting at the peace talks force the Lion King Lagravis to exile his own son. Laval learns that Cragger has imprisoned his father in his absence. He must free him ... but how can he do that when he has been exiled?
18. The Black Cloud A strange Black cloud has appeared around the floating Mt. Cavora, source of the CHI. Laval and Eris investigate but the cloud seems to fight back. The tribes of CHIMA must all join in the fight against the cloud. But the worst is yet to come...
19. CHIMA Falls The CHI falls have run dry. Eris and the Beavers try to get to mount Cavora to learn why. The Crocodiles blame the Lions and are rallying the Wolves, Ravens and even Rhinos for a large scale attack to conquer the remaining CHI.
|Peder Pedersen
|David Attar, Bethany Brown
|Supporting actors
|Bill Courage, Meghan Kinsley, Michael Patric, Scott Shantz, Jeff Evans Todd
|Season year
|Warner Bros.
|Tim Ainley, Tommy Andreasen, Alexandre Boudon, Craig Callum, Ole Holm Christensen, Søren Gehlert Dyrhøj, Sean Feeney, Thomas Sebastian Fenger, Adrian Florea, Torsten Jacobsen, Vicky Kjaer Jensen, Samuel Thomas Johnson, Callan Jay Kemp, Lilian Klages, Lotte Kronborg, Erik Legernes, Daire McCabe, Phil McCormick, Mads Munk, Jesper C. Nielsen
|Purchase rights
|Stream instantly and download to 2 locations Details
|Amazon Instant Video (streaming online video and digital download)


text:
February 15, 2001
In 2000, 394,000 employees were involved in major work stoppages. This was up from just 73,000 in 1999.
Two-thirds of the year's idled workers were involved in three major disputes. The largest stoppage in terms of workers idled involved 135,000 actors in commercials. The next largest involved 85,000 communication and electrical workers at Verizon Communications. The third largest was a one-day stoppage at Los Angeles County by 47,000 workers represented by the Service Employees International Union.
These data are a product of the BLS Office of Compensation and Working Conditions, Collective Bargaining Agreements. Learn more about work stoppages from news release USDL 01-41, "Major Work Stoppages, 2000." Major work stoppages are defined as strikes or lockouts that idle 1,000 or more workers and last at least one shift.
Bureau of Labor Statistics, U.S. Department of Labor, The Economics Daily, More workers involved in work stoppages in 2000 on the Internet at http://www.bls.gov/opub/ted/2001/feb/wk2/art04.htm (visited October 13, 2015).
New estimates of personal taxes in Consumer Expenditure Survey
In 2013, the Consumer Expenditure Survey improved its personal tax data.
Trends in long-term unemployment
Long-term unemployment reached historically high levels following the recession of 2007–2009.
Housing: before, during, and after the Great Recession
looks at consumer expenditures on household items, employment in residential construction, prices for household items, and injuries in occupations involved in building and maintaining our homes.


text:
Hampton Inn & Suites Lethbridge Ab Cn
Hampton Inn & Suites Lethbridge Ab Cn
Hotel Guest Rating: 9.0/10
4073 Second Avenue South
Lethbridge, AB T1J 2Z3
Welcome to the Hampton Inn & Suites Lethbridge Ab Cn
A complimentary breakfast, free Wi-Fi and an indoor pool and hot tub are welcome features at the non-smoking Hampton Inn and Suites Lethbridge, located less than a mile from Nikka Yukko Japanese Garden.
Hotel Features
This four-story hotel has 87 non-smoking rooms with free Wi-Fi and flat-panel cable TVs with in-room movies. A work desk and lap desk are standard, along with a hairdryer and ironing facilities. Guests can enjoy a dip in the heated indoor pool, a soak in the hot tub or a workout in the fitness center. The Hampton Inn also provides a complimentary hot breakfast with waffles and a business center. Parking is free.
Hotel Location
The Hampton Inn is located off Highway 3, less than a mile from Henderson Lake and Nikka Yukko Japanese Garden. Downtown Lethbridge, within six miles, is where guests can explore the Galy Museum, shop in Park Place Shopping Centre or enjoy the sun at Helen Schuler Nature Centre. Lethbridge Country Club and the University of Lethbrige are about a 15-minute drive from the hotel, and Lethbridge Airport is six miles south. Calgary International Airport is 146 miles north.
Guest Favorites
Priceline guests think the Hampton Inn is "fabulous," and rave about the "friendly service," "spacious" rooms, "nice" breakfast and convenient location near shops and restaurants.
Hampton Inn & Suites Lethbridge Ab Cn Amenities
- Air conditioning
- Air conditioning individually controlled in room
- Alarm clock
- Buffet breakfast
- Business center
- Cable television
- Cocktail lounge
- Coffee shop
- Complimentary buffet breakfast
- Complimentary cocktails
- Complimentary coffee in lobby
- Complimentary in-room coffee or tea
- Concierge desk
- Desk with electrical outlet
- Direct dial telephone
- Exercise gym
- Express check-out
- Family plan
- Fire safety compliant
- Fitness center on-site
- Free high speed internet connection
- Free parking
- Gift/News stand
- Grocery shopping service available
- Hairdryer
- Heated guest rooms
- High speed internet access fee
- Indoor pool
- Interior corridors
- Iron
- Ironing board
- Jacuzzi
- Late check-out available
- Laundry/Valet service
- Lobby coffee service
- Meeting rooms
- Non-smoking
- Non-smoking rooms (generic)
- On-site business center
- On-site business center is staffed
- On-Site parking
- Parking
- Parking lot
- Photocopy center
- Pool
- Public address system
- Public area air conditioned
- Remote control television
- Safe deposit box
- Secured parking
- Security
- Sundry/Convenience store
- Transportation
- Transportation services - local area
- Transportation services - local office
- Valet cleaning
- Voice mail
- Welcome drink
- Whirlpool
Hotel Guest Reviews of the Hampton Inn & Suites Lethbridge Ab CnOur hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.
September 25, 2015
Senior Travelers
August 22, 2015
August 10, 2015
May 26, 2015
Family Traveling with Teens
November 4, 2014
This guest did not leave comments about this hotel.
August 29, 2013
Great location for the wedding we were going too
August 2, 2013
Senior Travelers
Location for a stop over to my vacation destination. Friendly helpful staff. Nice clean room with almost brand new linens. I was very pleased with this location. I would definitely stay here again on another trip. I enjoyed my stay. I would stay here again on a future trips! Make all hotel reservation through Priceline.com!
June 16, 2013
August 10, 2012
Senior Travelers
A nice hotel, new and would recommend it.
March 19, 2012
Senior Travelers
Super friendly front desk staff. They asked us if we wanted a wake up call before I'd even mentioned it, and even phoned again after the automated call just to make sure it worked. There was fresh coffee in the very clean lobby. They rushed to refill the coffee pots when low. The continental breakfast was the best we've ever had! Rooms were clean and spacious. Impressive.
(1 - 10 of 10 reviews)
- Quality Inn & Suites Lethbridge from $85 (0mi)
- Best Western Plus Service Inn & Suites from $103 (0.1mi)
- Coast Lethbridge Hotel & Conference Centre from $102 (1.3mi)
- Sandman Hotel Lethbridge from $68 (1.3mi)
- Superlodge Canada (1.3mi)
Most Popular Guest-Rated Hotels in Lethbridge
- Hampton Inn & Suites Lethbridge Ab Cn
- Holiday Inn Express Hotel & Suites Lehtbridge
- Ramada Lethbridge
Most Popular Business-Friendly Hotels in Lethbridge
Most Popular Family-Friendly Hotels in Lethbridge
- Hampton Inn & Suites Lethbridge Ab Cn
- Holiday Inn Express Hotel & Suites Lehtbridge
- Days Inn Lethbridge


text:
Latest on Radiation-Induced CarcinogenesisMonday, October 17, 2005 10:15 AM-12:00 PM Room No. 610/612
Chair(s): Barcellos-Hoff, Mary Helen
(SY023) Ionizing radiation disrupts epithelium-stroma interactions, a potential mechanism for IR-induced carcinogenesis.
Yuan, Zhi-Min *,1, 1 Dept. of Genetics and Complex Disease, Boston, MA, USA
ABSTRACT- Ample evidence suggests that the stromal microenvironment in which tumor cells develop profoundly influences many steps of epithelial tumorigenesis. Fibroblasts, a major cell type of the stromal compartment, may function as a stress monitor to interact with nearby epithelial cells and to modulate their response. The molecular details of the epithelium-stroma interaction, however, remain not completely understood. Using protracted low-dose ionizing radiation (IR), we demonstrate that human primary mammary stromal fibroblasts respond to low-dose IR by displaying a senescence-like phenotype in a dose-dependent and accumulative manner. To understand the potential influence of senescent stromal fibroblasts on neighboring mammary epithelial cells (MEC), we adopted a three-dimensional (3D) coculture system to study the epithelial-stromal interactions in a tissue-like context. We provide a direct experimental proof that senescent fibroblasts dysregulate the growth of associated MECs under the 3D setting, resulting in aberrant proliferation, morphogenesis and invasion. Further analysis indicates that these effects are mediated through altered cell-cell and cell-matrix interactions because of impaired cytoskeletal regulations and heightened matrix degradative functions of senescent fibroblasts. Importantly, the outcomes of the senescent fibroblast-derived growth modulation on mammary epithelial cells are dependent upon the genetic status of epithelial cells. Mammary epithelial cells with inactivated cell death pathways or those undergoing epithelial-mesenchymal transition fully display their malignant behaviors in the presence of senescent fibroblast. Furthermore, we demonstrate that the heterotypic interactions between senescent fibroblasts and MECs also influence the stress response of MECs, which display increased radio- and chemo-resistance in both two-dimensional and 3D contexts. Together, our results suggest that low-level environmental stress can foster an oncogenic environment that interacts with permissive genetic traits in epithelial cells to promote breast carcinogenesis.
Key words: epithelium-stroma interaction, 3-dimentional coculture, heterotypic interaction
Internet Services provided by
Allen Press, Inc. | 810 E. 10th St. | Lawrence, Kansas 66044 USA
e-mail email@example.com | Web www.allenpress.com