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A plan to resolve the Chukker Creek Road school traffic congestion got first approval Monday evening by Aiken City Council.
The vote on first reading was unanimous to allow an 1,800-feet extension of the driveway of Chukker Creek Elementary School located at 1830 Chukker Creek Road. An additional 40 parking spaces were also requested, which was approved on first reading as well.
The school has 852 students and only 10 to 15 percent of them use the bus. The school currently has 650 feet of driveway for drop-offs and pick-ups. Pick-up, which starts at 2 p.m., is said to be the peak traffic time and approximately 1,800 feet of cars have been seen parked on Chukker Creek Road toward Whiskey Road and approximately 500 feet toward Plantation South, according to Civil Engineer Tilden Hilderbrand.
Councilwoman Gail Diggs asked how long it takes for the traffic to clear during drop-off and pick-up. Hilderbrand said it takes approximately an hour for all the vehicles to clear.
Hilderbrand presented a conceptual drawing of a serpentine driveway that would wrap around the east and north portion of the property to accommodate the traffic. The S.C. Department of Transportation approved the plan prompted by Aiken County School District to fix the problem.
Some residents who reside on or off of Chukker Creek Road asked Council to approve the plan before there is a serious or fatal accident.
Tony Sealy was one of those residents and he described the current traffic situation difficult and dangerous.
"I think this is a very good approach to solve that problem and I hope you vote in favor of it," he said to Council.
Sandy Randall, another resident who lives off Chukker Creek Road, said her main concern was for the safety of the children.
"If you lose a child, you can't get that child back," Randall said. "This is a very dangerous, dangerous situation."
Lots that line the east and north portion of the school's property are in the Woodside neighborhood and concern was expressed by some of those residents about the serpentine driveway bringing the vehicles closer to their homes. Residents were also uncomfortable with the possibility of not having a thick enough buffer to help muffle noise coming from the school as well as keeping them from being exposed to fumes from idling engines.
Since the Planning Commission meeting earlier this month when the conceptual drawing was first presented, Hilderbrand increased the proposed 10-foot undisturbed buffer to 25 feet.
Hilderbrand added that if the plan is approved, the closest the extended driveway would be to the eastside property lines would be approximately 36 feet and 42 feet to the northside property lines.
Retired engineer Philip Winsor lives on the back end of the school's property and said he agrees that there is a traffic problem but does not agree with the proposed solution. He presented his own plan that would not include the serpentine design but rather adding parallel lanes in the pick-up area.
The final reading will be held at the next Aiken City Council meeting to take place on Feb. 11.
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We aren't TTC yet but I am trying to get my ducks in a row before we start in April.
When I saw my OB for my pp appointment last year, she basically asked me if I was ready to have my tubes tied. I was shocked. She said that she recurrence rate for me is too high and she wants me to know that. I definitely was not ready for that.
So, I decided to see a MFM a while later. This MFM was VERY inexperienced. I'm pretty sure she was a resident that they stuck with me with or fresh out of med school or something. Anyway, she basically spouted out everything I already knew. It wasn't a great experience there but I know there are other doctors there that are more experienced. They did say they would be my primary OB only. The one downfall of this is this place is 45 minutes away. With frequent visits and NSTs and such, that would be A LOT of driving. She quoted me 50% chance of developing Pre-e again.
I saw a second MFM a few months ago. He actually came to our local hospital to meet me (he consults there) and his practice is an hour away. (we don't have MFMs near by) I LOVED this guy. He made me feel so at ease and answered my questions. The problem is, he would not be my primary OB. I think they deal with consults only. I would probably see him periodically and see my regular OB mainly. He quoted me 25% chance of developing severe pre-e again. He was very optimistic.
My OB is actually at the same doctors office I work at. So, there is a convenience factor there. BUT I feel like because I work with the OB's, last time I was kind of "brushed aside". My BP was really elevated and I had HORRIBLE swelling and they told me it was fine. If I hadn't been so persistent, who knows where we would be today.(side note: My regular OB was out of town when all this went down) I also feel like she wouldn't be very supportive because she thinks I'm doomed to have another preemie. I don't even know if she would feel 100% comfortable mananging my pregnancy. She had me on the wrong BP med last time.So, obviously she isn't that experienced with high risk patients. I do know that I would request to see only her in our practice, not sure if that will cause strife but oh well. I obviously will talk to my OB and see if she feels comfortable, etc. and seeing the MFM in conjunction will also be better because he can make the "important" decisions like increasing BP med, etc. I also know that she would take me very seriously next time and I knoew her and feel comfortable with her.
But what do you guys think? What would you do in this situation?

subset: commoncrawl


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In medical school, some of my classmates and I, those who sat in the back row, designed a professorial rating system. The metric we created was the "Snooze Factor."
This is how it worked. Midway through the lecture, we would count the number of students (numerator) who were snoozing and divide that number (denominator) by the total number of students in class. Our premise was that the best professors kept us engaged in the lecture, and the least proficient did not. As a surrogate marker of the overall quality of the course, we would rate professors on their average snooze factor.
I have to admit that these many years after I sat in a medical school lecture hall, I still find myself surveying audiences during presentations at conferences, just to see how everyone is doing. And in my head, I start calculating the snooze factor. I did that today.
The snooze factor was very low. The presentations were exceptional and the content thought-provoking and challenging. No one (well, almost no one) was sleeping.
I was quite surprised to find that Dr. Schneider also used the snooze factor. He commented, "Wonderful meeting. Dr. Schneider stayed awake the whole time." That's high praise from any physician, in my estimation.
Dr. Boon likewise was taken with the first two presentations: Generative Governance, and The New Realities of Care Delivery and Accountability. The latter stimulated a robust conversation amongst the physicians about what the potential impact of social media, telemedicine, technology, and self-generating – organizing without organization – and what it might mean for healthcare delivery in the future. In the end we all agreed, we couldn't predict the future, but that the future was very interesting.
Dr. Novinski also thought that the New Realities presentation was eye-opening. In fact, moved by the presentation to step into new communication tools, he attempted to Tweet me his thoughts about the day. But it failed, for some reason – either end-user failure on my part or misfiring on his part. This is what happens when the Baby Boomers stumble into the territory of the Millennials. Since we fumbled on our foray into the new reality, we reverted to a tried and true method of communication – we talked face-to-face.
Next I'll give a brief synopsis on the presentations from the first day


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Document Type
- Article (37) (remove)
- Human monoclonal antibody combination against SARS coronavirus : synergy and coverage of escape mutants (2006)
- Background: Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible. For an effective immune prophylaxis in humans, broad coverage of different strains of SARS-CoV and control of potential neutralization escape variants will be required. Combinations of virus-neutralizing, noncompeting mAbs may have these properties. Methods and Findings: Human mAb CR3014 has been shown to completely prevent lung pathology and abolish pharyngeal shedding of SARS-CoV in infected ferrets. We generated in vitro SARS-CoV variants escaping neutralization by CR3014, which all had a single P462L mutation in the glycoprotein spike (S) of the escape virus. In vitro experiments confirmed that binding of CR3014 to a recombinant S fragment (amino acid residues 318–510) harboring this mutation was abolished. We therefore screened an antibody-phage library derived from blood of a convalescent SARS patient for antibodies complementary to CR3014. A novel mAb, CR3022, was identified that neutralized CR3014 escape viruses, did not compete with CR3014 for binding to recombinant S1 fragments, and bound to S1 fragments derived from the civet cat SARS-CoV-like strain SZ3. No escape variants could be generated with CR3022. The mixture of both mAbs showed neutralization of SARS-CoV in a synergistic fashion by recognizing different epitopes on the receptor-binding domain. Dose reduction indices of 4.5 and 20.5 were observed for CR3014 and CR3022, respectively, at 100% neutralization. Because enhancement of SARS-CoV infection by subneutralizing antibody concentrations is of concern, we show here that anti-SARS-CoV antibodies do not convert the abortive infection of primary human macrophages by SARS-CoV into a productive one. Conclusions: The combination of two noncompeting human mAbs CR3014 and CR3022 potentially controls immune escape and extends the breadth of protection. At the same time, synergy between CR3014 and CR3022 may allow for a lower total antibody dose to be administered for passive immune prophylaxis of SARS-CoV infection.
- GEANT4 : a simulation toolkit (2003)
- Abstract Geant4 is a toolkit for simulating the passage of particles through matter. It includes a complete range of functionality including tracking, geometry, physics models and hits. The physics processes offered cover a comprehensive range, including electromagnetic, hadronic and optical processes, a large set of long-lived particles, materials and elements, over a wide energy range starting, in some cases, from 250 eV and extending in others to the TeV energy range. It has been designed and constructed to expose the physics models utilised, to handle complex geometries, and to enable its easy adaptation for optimal use in different sets of applications. The toolkit is the result of a worldwide collaboration of physicists and software engineers. It has been created exploiting software engineering and object-oriented technology and implemented in the C++ programming language. It has been used in applications in particle physics, nuclear physics, accelerator design, space engineering and medical physics. PACS: 07.05.Tp; 13; 23
- Azimuthal anisotropy in Au+Au collisions at SNN=200GeV (2005)
- The results from the STAR Collaboration on directed flow (v1), elliptic flow (v2), and the fourth harmonic (v4) in the anisotropic azimuthal distribution of particles from Au+Au collisions at sqrt[sNN]=200GeV are summarized and compared with results from other experiments and theoretical models. Results for identified particles are presented and fit with a blast-wave model. Different anisotropic flow analysis methods are compared and nonflow effects are extracted from the data. For v2, scaling with the number of constituent quarks and parton coalescence are discussed. For v4, scaling with v22 and quark coalescence are discussed.
- Erratum: Midrapidity antiproton-to-proton ratio from Au+Au collisions at sqrt[sNN]=130 GeV [Phys. Rev. Lett. 86, 4778 (2001)] (2003)
- Evidence for an exotic S=-2, Q=-2 baryon resonance in proton-proton collisions at the CERN SPS (2004)
- Results of resonance searches in the Xi - pi -, Xi - pi +, Xi -bar+ pi -, and Xi -bar+ pi + invariant mass spectra in proton-proton collisions at sqrt[s]=17.2 GeV are presented. Evidence is shown for the existence of a narrow Xi - pi - baryon resonance with mass of 1.862±0.002 GeV/c2 and width below the detector resolution of about 0.018 GeV/c2. The significance is estimated to be above 4.2 sigma . This state is a candidate for the hypothetical exotic Xi --3/2 baryon with S=-2, I=3 / 2, and a quark content of (dsdsu-bar). At the same mass, a peak is observed in the Xi - pi + spectrum which is a candidate for the Xi 03/2 member of this isospin quartet with a quark content of (dsusd-bar). The corresponding antibaryon spectra also show enhancements at the same invariant mass.
- Event-wise <pt> fluctuations in Au-Au collisions at sqrt[sNN]=130 GeV (2005)
- We present the first large-acceptance measurement of event-wise mean transverse momentum <pt> fluctuations for Au-Au collisions at nucleon-nucleon center-of-momentum collision energy sqrt[sNN] = 130 GeV. The observed nonstatistical <pt> fluctuations substantially exceed in magnitude fluctuations expected from the finite number of particles produced in a typical collision. The r.m.s. fractional width excess of the event-wise <pt> distribution is 13.7±0.1(stat) ±1.3(syst)% relative to a statistical reference, for the 15% most-central collisions and for charged hadrons within pseudorapidity range | eta |<1,2 pi azimuth, and 0.15 <= pt <= 2 GeV/c. The width excess varies smoothly but nonmonotonically with collision centrality and does not display rapid changes with centrality which might indicate the presence of critical fluctuations. The reported <pt> fluctuation excess is qualitatively larger than those observed at lower energies and differs markedly from theoretical expectations. Contributions to <pt> fluctuations from semihard parton scattering in the initial state and dissipation in the bulk colored medium are discussed.
- Open charm yields in d+Au collisions at sqrt[sNN]=200 GeV (2005)
- Midrapidity open charm spectra from direct reconstruction of D0(D0-bar)-->K± pi ± in d+Au collisions and indirect electron-positron measurements via charm semileptonic decays in p+p and d+Au collisions at sqrt[sNN]=200 GeV are reported. The D0(D0-bar) spectrum covers a transverse momentum (pT) range of 0.1<pT<3 GeV/c, whereas the electron spectra cover a range of 1<pT<4 GeV/c. The electron spectra show approximate binary collision scaling between p+p and d+Au collisions. From these two independent analyses, the differential cross section per nucleon-nucleon binary interaction at midrapidity for open charm production from d+Au collisions at BNL RHIC is d sigma NNcc-bar/dy=0.30±0.04(stat)±0.09(syst) mb. The results are compared to theoretical calculations. Implications for charmonium results in A+A collisions are discussed.
- Azimuthal anisotropy and correlations at large transverse momenta in p+p and Au+Au collisions at sqrt[sNN] = 200 GeV (2004)
- Results on high transverse momentum charged particle emission with respect to the reaction plane are presented for Au+Au collisions at sqrt[sNN]=200 GeV. Two- and four-particle correlations results are presented as well as a comparison of azimuthal correlations in Au+Au collisions to those in p+p at the same energy. The elliptic anisotropy v2 is found to reach its maximum at pt~3 GeV/c, then decrease slowly and remain significant up to pt ~ 7-10 GeV/c. Stronger suppression is found in the back-to-back high-pt particle correlations for particles emitted out of plane compared to those emitted in plane. The centrality dependence of v2 at intermediate pt is compared to simple models based on jet quenching.
- Transverse-momentum dependent modification of dynamic texture in central Au+Au collisions at sqrt[sNN]=200GeV (2005)
- Correlations in the hadron distributions produced in relativistic Au+Au collisions are studied in the discrete wavelet expansion method. The analysis is performed in the space of pseudorapidity (| eta | <= 1) and azimuth(full 2 pi ) in bins of transverse momentum (pt) from 0.14 <= pt <= 2.1GeV/c. In peripheral Au+Au collisions a correlation structure ascribed to minijet fragmentation is observed. It evolves with collision centrality and pt in a way not seen before, which suggests strong dissipation of minijet fragmentation in the longitudinally expanding medium.
- Pion interferometry in Au+Au collisions at sqrt[sNN]=200GeV (2005)
- We present a systematic analysis of two-pion interferometry in Au+Au collisions at sqrt[sNN]=200GeV using the STAR detector at Relativistic Heavy Ion Collider. We extract the Hanbury-Brown and Twiss radii and study their multiplicity, transverse momentum, and azimuthal angle dependence. The Gaussianness of the correlation function is studied. Estimates of the geometrical and dynamical structure of the freeze-out source are extracted by fits with blast-wave parametrizations. The expansion of the source and its relation with the initial energy density distribution is studied.


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Lifvation is a compound word of Life & Innovation.
We build, manage and grow innovative lifestyle brands.
- Built: our brands are built organically or through acquisition.
- Manage: we manage all our brands for at least a year. This allows us to iron out all the kinks.
- Grow: we grow each brand to its full potential.
We invest heavily in 7 expertise so that we can build up a valuable brand portfolio and groom each brand to its fullest potential.
Our expertise: software, IP, distribution, marketing, sales, education and operation excellence.


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Home to world-renowned DJs Tiësto, Calvin Harris, Hardwell, Steve Aoki and more, the nightclub at Hakkasan LasVegas was named one of "America's Best New Clubs" by Rolling Stone and awarded the title of "No. 1 Nightclub in the World" by Playboy Magazine.
Envisioned by Hakkasan Group - a worldwide entertainment, dining, nightlife, and hospitality company - Hakkasan Las Vegas is a five-level culinary and nightlife mecca located at MGM Grand Hotel & Casino. The awe-inspiring venue is a bold evolution of the prestigious global restaurant brand into an all-encompassing nightlife experience, featuring premier talent across various genres that have tailored their performances to suit the unique capabilities of the space. Hakkasan Nightclub offers cutting-edge technology, inspired design immersed in three levels of refined decadence and a variety of areas and atmospheres including the Ling Ling Lounge, Ling Ling Club, Main Room, Pavilion and Mezzanine.
Legendary DJ and producer Tiësto continues to captivate revelers with the unique and energetic sound of his "Club Life" residency at Hakkasan Nightclub. Tiësto has received numerous honors throughout his momentous music career including "No. 1 DJ" by Rolling Stone,"The Greatest DJ of All Time" by MixMag in 2011, a GRAMMY Award nomination and several MTV Awards. Tiësto is a sought after producer and DJ, working with superstars including Kanye West, Coldplay, Katy Perry, Nelly Furtado, Yeah Yeah Yeahs and Goldfrapp. With more than 15 million Facebook friends, 2.4 million Twitter followers, 400 million YouTube views, his own Sirius XM channel, a globally syndicated radio show and his Club Life iTunes artist podcast (No. 1 music podcast globally), Tiësto is a universal phenomenon.
Calvin Harris
World-renowned artist and resident of Hakkasan Nightclub Calvin Harris continues to bring his energetic sounds to the Las Vegas hot spot. The DJ, producer and songwriter first hit the dance music scene in 2006 with his gold-selling album, I Created Disco. Reigning from Scotland, Harris has gained international recognition for his work in the electronic music scene including his chart-topping collaborations with the industry's elite. He has been recognized with multiple awards including Best Electronic Video for "Feel So Close" and Video of the Year for "We Found Love" with Rihanna at 2012 MTV Video Music Awards, and a GRAMMY Award for Best Short Form Music Video in 2013. Harris also holds the record for the most top ten hits from one studio album on the UK Singles Chart with nine hits from his album, 18 Months, surpassing Michael Jackson.
Dutch titan Hardwell brings his infectious music to his exclusive event series at Hakkasan Nightclub. He finished 2013 at the top of the charts, further cementing himself as a force in the electronic music scene with the award of World's No.1 DJ by the 2013 DJ Mag Top 100 DJs Poll. Hardwell mesmerizes clubgoers with his refreshing sound and customized visuals. Hardwell's "fresh and open-minded" approach to electronic music has propelled him to stardom, and his event series at Hakkasan is a true representation of the artist's position on the frontier of electronic music parties.
Steve Aoki returns to Hakkasan Nightclub with the enthralling electronic sounds and hard-hitting beats of his highly energetic events. The DJ, producer and California Native began his musical career in 1996 as founder of Dim Mak Records. The label has released more than 250 records including Aoki's own collaboration with fellow DJ Tiësto. Aoki launched his career as an electronic artist with his 2012 album Wonderland, for which he received a GRAMMY Award nomination in the Best Dance/Electronic Album category. Aoki continues to captivate dance floors and concert halls around the globe with his remixes and collaborations with some of the best known DJs and recording artists of our time.


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Robert "Bob" Milam, 82, died Tuesday, Jan. 22 at the hospice care center in Hazard.
He was born Feb. 3, 1930 in Pigeon Roost, the son of the late Dewey Milam and the late Martha Couch Milam, and was also preceded in death by his son Joel David Milam, and his sister, Marie Wooton.
He was a retired machinist with Priest Coal Company, a life-long resident of Perry County, and a member of the Typo Church of the Living God, where he served as a longtime pastor.
He is survived by his wife of 59 years, Ima Jean Milam of Bonnyman; sons Tim Milam of New York, Robert Michael Milam of Florida, Paul Milam of Georgia, and Phillip Milam of Bonnyman; sisters Mary Elizabeth Campbell of Hazard, Belvia McIntosh of Willard, and Delphia Bishop of Bonnyman, and a host of other relatives and friends.
Funeral services will be conducted on Friday, Jan. 25 at 11 a.m. at the Engle-Bowling Funeral Home of Hazard with Curt Eversole and Ed Bishop officiating. The interment will follow in the Couch Family Cemetery located at Forked Mouth at Busy. The visitation will be on Thursday evening from 6 to 8 p.m. Military rites will be performed by the Hazard-Perry County DAV Chapter 64.


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(b) In primary elections a plurality of the votes cast shall be sufficient for the nomination of candidates for office. Where only one candidate of a political party for any office in a political division, including party committeemen and delegates to national conventions, is to be chosen, or where a judicial circuit has two or more circuit judges and one circuit judge is to be chosen for each numbered division within the circuit, the candidate receiving the highest number of votes therefor in the primary election shall be declared the party nominee for such office. Where two or more such candidates are to be chosen in the primary election, the candidates constituting the proper number to be so chosen who shall receive the highest number of votes cast in the political division in which they are candidates shall be declared the party nominees and choices for such offices, except that:
(1) Candidates for the office of commissioner of the county commission shall be nominated and elected in accordance with the provisions of section ten, article nine of the Constitution of the state of West Virginia and the requirements of section one-b, article one, chapter seven;
(2) Members of county boards of education shall be elected at primary elections in accordance with the provisions of sections five and six of this article;
(3) Candidates for the House of Delegates shall be nominated and elected in accordance with the residence restrictions provided in section two, article two, chapter one of this code; and
(4) In judicial circuits having numbered divisions, each numbered division shall be tallied separately and the candidate in each division receiving a plurality of the votes cast shall be declared the party nominee for the office in that numbered division.
(c) In case of tie votes between candidates for party nominations or elections in primary elections, the choice of the political party shall be determined by the executive committee of the party for the political division in which such persons are candidates.
Note: WV Code updated with legislation passed through the 2015 Regular Session
The WV Code Online is an unofficial copy of the annotated WV Code, provided as a convenience. It has NOT been edited for publication, and is not in any way official or authoritative.


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If ever the cooking thing doesn't work out, Edward Lee and Ashley Christensen can always do stand-up comedy.
Tickets remain for the following events at the 2013 BB&T Charleston Wine + Food Festival. Check the website, charlestonwineandfood.com, for information and to purchase. Tickets also may be purchased at Marion Square.TodayLowcountry Jazz Brunch, 11 a.m. $105.Culinary Village, 1-4 p.m. $85 or $70 for locals.Rigs, Pigs + Swigs, 5-8 p.m. $85.
Neither of the guest chefs — he from 610 Magnolia in Louisville, Ky., and she from Pooles Diner in Raleigh, — was awarded the "golden waffle" in the Waffle House Smackdown Saturday in Marion Square. But as for laughs, they completely won the crowd over.
The two joined local chefs Mike Lata of FIG and Michelle Weaver of Charleston Grill during a 90-minute "competition" that was part of the 2013 BB&T Charleston Wine + Food Festival. The women cooked against each other in round one, the men in round two, and a final round determined the winner.
Bon Appetit Editor Andrew Knowlton egged on the action as host of the event.
Moments before her 10-minute faceoff with Weaver, Christensen addressed the four judges seated at a table below the raised stage. "I just want to say, you guys look great today," she deadpanned.
Lee, wearing a paper yellow-and-black Waffle House side cap like the others, came on the stage for introductions nursing a Pabst tallboy. He stoked his bad-boy demeanor by not playing by the "rules," at one point dumping grape jelly and jalapenos on his hash browns.
And when he put dry toast on his omelet plate, a voice in the audience called out, "It's not buttered!"
"Oh, don't you worry about that," Lee muttered as he grabbed a ladle, dipped it to overflowing with melted butter and poured it on. The crowd crowed with delight.
The two local chefs weren't too shabby in the laugh department either.
When Christensen boasted to the judges that her toast was facing the eggs on her plate "in the Waffle House way," Weaver delivered a zinger. "I was told to make sure there were hash browns, not hash tans," Weaver retorted.
Lata won the final challenge — "Pull one bacon; drop one hash brown in a ring; order over light plate; waffle" — and picked up Waffle House's ultimate title, "Master Blaster."
"What's the prize?" asked Knowlton. "Does he get to take Ed home with him?"
Christina Jackson and three other women, all from North Carolina, laughed all the way through. They were spending the day in the festival's Culinary Village.
They arrived in town Friday and were planning to return today.
"This is my second year," said Jackson, 39. "I had so much fun last year that I had to come back and bring some new friends."
Edward Lee (right), a visiting chef from Louisville, Ky., was in great spirits Saturday during the Charleston Wine + Food Festival Waffle House Smackdown, but FIG's Mike Lata had the last laugh — he won the lighthearted competition.×
Michelle Weaver of Charleston Grill joined three other chefs in laughing their way through the Waffle House Smackdown on Saturday at Marion Square.×
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|Wyndham Hotels Dallas hotels are provided below. Search for cheap and discount Wyndham Hotels hotel rooms in Dallas, TX for your group or personal travels. We list the best Wyndham Hotels Dallas properties so you can review the Dallas Wyndham Hotels hotel list below to find the perfect place.
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Simple beads are a popular style in every aspect of jewelry. These 8mm 14K gold filled bead earrings are a great way to make a stylish statement without going over the top. The look of gold is a classic that everyone loves, and these gold fill bead earrings will last for years to come, and will surely be an instant favorite in your wardrobe! These look great with any gold piece you may already own, or one of our other gold filled or gold vermeil pieces.
Eve's Addiction.com wants you to be a happy customer. We want you to be completely satisfied with the sterling silver jewelry that you receive from us, as we only sell high quality silver and cubic zirconia cz jewelry. We do understand that you may not like your purchase for some reason.
You may return or exchange your jewelry within 60 days of purchase if you are not satisfied with it. The jewelry must be returned in its original condition for a refund or exchange. Engraved, personalized, photo, monogram, name and initial, chocolate and clearance items are not returnable or exchangeable.


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I wasn't a fan of MP3. It wasn't a bad game if I were to judge it as a critic, but I had very little fun playing it. Some very annoying gameplay mechanics in it too.
Like what?
I can see being annoyed at the lengthy cut scenes if you have add but I don't remember any annoying gameplay mechanics.


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A couple of weeks following the previous seed, Apple has released OS X 10.9 Mavericks Developer Preview 7 to registered developers. The update is available via Software Update in the Mac App Store. If you find anything new, you can let us know at firstname.lastname@example.com. We'll be updating this post as changes are discovered. A new Apple Remote Desktop 3.7 seed has also been issued.
– Several new wallpapers included in System Preferences.
– The new release points to a new Mavericks website detailing the new features (not live yet).
A tipster has sent in release notes:
iCloud and iCloud Keychain
- iCloud Keychain users will be prompted to reenable iCloud Keychain after installing Developer Preview 7.
- Network migration from earlier versions of OS X requires the Migration Update for Snow Leopard, Lion, or Mountain Lion, available from the Mac Dev Center.
- Migration from Windows is not supported in Developer Preview 7.
- PDFs imported into iBooks in previous seeds of OS X Mavericks may be renamed when opened with Preview.
- Screen recordings taken with Developer Preview 7 are not compatible with earlier releases of OS X.
- Fusion Drive volumes created with Developer Preview 7 are not compatible with OS X v10.8.4 or earlier.
- Moving a full-screen Aperture window to a secondary display may prevent the app window from being visible in subsequent attempts to use full screen.
- In Full Screen in Aperture, some menus and thumbnails aren't immediately available until interacted with by the user.
- When in Full Screen in Aperture, the toolbar at the top of the window may not be usable until it is locked.
- Starting in Developer Preview 4, non-admin users will be allowed to install and update software from the Mac App Store. This functionality can be disabled with a profile that sets the "restrict-store-require-admin-to-install" key to true (boolean) in the com.apple.appstore domain.
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12 Responses to "Apple releases OS X Mavericks Developer Preview 7"
It sent me a notification, to ask me if I wanted to learn about whats new in the OS. It then sent me to this web page: https://help.apple.com/osx-mavericks/whats-new
Same here
This release fixed my AirPlay Mirroring… Just in time for NFL Sunday Ticket streaming!
"Starting in Developer Preview 4, non-admin users will be allowed to install and update software from the Mac App Store. This functionality can be disabled with a profile that sets the "restrict-store-require-admin-to-install" key to true (boolean) in the com.apple.appstore domain."
It's good to have option. Me who is using the terminal like every day don't have a problem finding this option.. I wonder if there will be a GUI checkbox in the Security page in System preferences later on?
New info icon in disk utility
How did you notice that? I use diskutil everyday and there is no way I would have seen that
Don't know about anyone else but iTunes Radio is finally working in iTunes. Could never get it to work in previous betas…
Since the update my Aperture has Problems to show the original *.CR2 RAW Files, it's say that the filetype is not supported. Problems are on Macbook Pro and Mac Pro! I can reprocess the image, but i have to open everyone first!
Some solutions or same problems?
Found a solution – It's the Apple "Digital Camera RAW Compatibility Update".
Delete in Finder
Download and install the "Digital Camera RAW Compatibility Update 4.07″ and NOT update to 4.08 (http://support.apple.com/kb/DL1666).
Than it should work!
So, FaceTime and PhotoBooth were not working in DV6 but they both are working fine now..


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It was a contest that required finely honed detective skills. The challenge: find all four Spawn banners advertising the new 10th Anniversary DVD of HBO's Spawn Animated Series; click the banners to reveal the hidden passwords, and then send those passwords to us.
The stakes were high. The first five correct entrants receive the new Spawn Animated Series DVD and a McFarlane-signed Spawn lithograph. The next five runners-up each win a Spawn action figure three-pack.
We learned there are a lot of great Spawn fans with highly evolved detective skills!
Congratulations to the five signed lithograph winners:Greg Griffith of South Norwood, LondonClayton Parker of New York, N.Y.John Purvine of Roseburg, Ore.Javier Araya of Buda, TexasDaniel Neault of Montreal, QuebecAnd put your hands together for the five Spawn 3-pack winners:Amber Patton of Lima, OhioJacob Cooper of Milwaukie Ore.Douglas Drazin of West Bloomfield, Mich.Nicolas Jones of Dallas, TexasJami Daniels of Orlando, Fla.A big thank you from all of us to everyone who entered!


text:
something here maybe ... or not
something here maybe ... or not
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There is no question iOS devices target a need in many businesses -- but Apple could unleash a flood of enterprise adoptions if they would get on the ball regarding enterprise licensing + custom app distribution, which has frustrated quite a few companies who would like to adopt iOS, but cannot. Macworld had a decent summary recently. ( http://bit.ly/aCXNIi )
iPad Becoming More Popular With Corporations
According to a survey conducted by BoxTone Mobile Service Management, Apple's iPad is becoming increasingly popular with corporations. They recently conducted several webinars to find out what IT departments felt about utilizing Apple's iPad.
BoxTone recently conducted three large Webinars on the topic of securing and managing enterprise iPads at the point of use. During the Webinars, BoxTone leveraged an interactive polling feature to garner the responses from nearly 1200 IT professionals and line of business executives at more than 800 enterprises, government agencies and Managed Services Providers. Half of the survey respondents were from the Fortune® 100; and nearly one-third of the companies participating in the surveys were in the Fortune® 500. Over 10 percent of all respondents were members of the executive tier and C-suite.
Some interesting findings were that 73% of the surveyed companies intend on deploying the iPad as well as other iOS devices for use on their network within the next 12 months, with 25% of those companies set to deploy right away. More than 50% of those surveyed plan on deploying their own iPad app within the next 12 months, while 25% of those plan on deploying as many as three of their own iPad apps.
It is clear that iPad adoption has been fairly quick on the consumer end and now it looks as though it will be a welcome new addition into the corporate world. As the iPad only evolves in features and specs I can only imagine the growth it will continue to have in both the consumer and corporate markets.
Do you work for a company that has adopted the iPad or other iOS device into its ecosystem? If so how do you utilize the iPad in your daily work? Sound off in the comments below as we would like to hear how your company is utilizing Apple's revolutionary tablet.
Have something to say about this story? Leave a comment! Need help with something else? Ask in our forums!
Reader comments
iPad Becoming More Popular With Corporations
I work for an online development firm in Kansas City and we're installing iPad's in a client's retail store as purchase kiosks. We're getting around the app store hurdle making the iPad kiosks just run an optimized-for-ipad website connected to the store's inventory system and payment gateway. It's going to be really slick.
I use the ipad to do web ex meetings all the time for work now. I use it to check email and respond and find i hardly pull out my smart phone anymore and never lug my computer around. In a pinch i remote desktop to my pc if i need something there. Cisco VPN on iPad and remote desktop gets me very thing i need with no laptop and you really can type fast on the ipad keyboard, no joke. Reviewing PDF contracts and presentations, now i never print anything anymore either... Even when i need to just get away from my computer and read. iPad is never far from reach all day long.
We just deployed 10 iPads to our executive team. Our 2 biggest issues are that we work with small Exchange inboxes and file everything in .pst files, which aren't readily available on the iPads.
The second issue is the integration with Microsoft Excel. DocsToGo has an excellent file syncing tool, but doesn't allow editing of any of the Excel workbooks I've tried due to complex formulas (like average and sum :p). Numbers has been hit or miss and has a horrible set-up for syncing documents. Right now, we are deploying DocsToGo for file syncing and Numbers and OfficeHD for Excel use. We still have some workbooks that won't function and it costs about $40 to try to use Excel spreadsheets.
Worked for me on my jailbroken 4s, did it using Ifile. I don't know how you figured this out, but I'm SO grateful, that message was getting on my nerves!


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In the kind of contradictory report usually reserved for dietary claims, recently released data suggests that Pinterest is surprisingly ineffective in driving people to buy things on the Internet. Jirafe, a New York-based ecommerce analytics company, took a look at the behavior of 89 million online shoppers who visited their clients' 5,000 web stores in the last year. In terms of conversion rates (the percentage of visitors who actually bought something) and average purchase size, those coming from Pinterest placed fifth among traffic sources.
"There's so much excitement around Pinterest and a lot less analysis of data," says Amit Shah, Jirafe's CEO. " What we see is that Pinterest drives traffic, not revenue."
Here's a look at the data:
Conversion Rates
Bing: 1.3%
Google: 0.9%
Facebook: 0.3%
Twitter: 0.2%
Pinterest: 0.1%
Average Order Size
Twitter: 5.3x
Google: 3.45x
Facebook: 2.5x
Bing: 2.1x
Pinterest: 1x
Jirafe's findings fly directly in the face of growing conventional wisdom that Pinterest is a force to be reckoned with in the ecommerce space. The social network has grown to a user base of over 20 million in the last year and recently raised $100 million at a $1.5 billion valuation from the Japanese ecommerce giant Rakuten in May. As recently as two months ago (in a post found here) I recounted some of the common data points supporting Pinterest's value as a marketing and referral tool:
Online retailers, like Katia Beauchamp from Birchbox, have noted that the increasing number of referrals generated by Pinterest makes it extremely valuable as an acquisition channel. According to MSNBC, 40 percent of all social media driven purchases are expected to come from Pinterest during this quarter. Shopify, a company that offers software for creating online stores, notes that Pinterest users are 10% more likely to make a purchase (within the Shopify network) than those who arrive from other sites.
How do we make sense of all of this conflicting information? For one, it's helpful to point out that a lot of claims about Pinterest are based on different metrics. Low conversion rates don't necessarily contradict evidence of Pinterest's (apparently) outsized share of social media driven purchases. Jirafe's findings hint that Pinterest users may do a lot of looking on many different websites before actually making a purchase. Previous reports of Pinterest's high revenue-per-click rates and Shopify's assertion that Pinterest users are more likely to make a purchase are more difficult to reconcile with Jirafe's data.
Shah pointed out that the real story is probably a bit more granular. "My hunch is that if you're J. Crew, Pinterest users might be more likely to buy from you," he says. "If your a mom and pop shop, the conversion may not be as good." While Jirafe 5,000 clients include the ecommerce wings of Zadig & Voltaire, Skype and Chipotle, the company serves very few of the top 500 online retailers. The Pinterest data for more established sites – as opposed to the longtail – may be a little brighter.


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Martin's back with some fascinating stats...
Martin Tyler's stats and facts column is here!
Every week on skysports.com he answers your questions and offers you statistical gems from what he's seen as he tours the world commentating for Sky Sports.
Sky Sports' voice of football and his back-up team of experts want your queries on all things statistical and historical from the beautiful game.
So if you have spotted something from a matche or have been stumped by a pub quiz question, simply email firstname.lastname@example.com and he will do his best to help.
Tyler's teaser
But as usual we'll kick off with a question for YOU. Click play to see this week's Tyler's Teaser.
Martin's Starting Stat
I saw Norwich beat Sunderland 2-1 on Sunday and they are now eight Premier League games unbeaten. It's the first time they've had a run like that since September to November 1993 (but, admittedly, they've not been in the Premier League that much in that period) and in those eight games, they have not conceded in the second half.
It was a fourth consecutive home win for them, but the other three had all been 1-0 so they didn't make it into a fourth consecutive shutout (which would have been for the first time since 1979). It was only the second time this season they've scored more than once - and the other time was a 5-2 home defeat to Liverpool.
Sunderland now have just two wins in their last 22 in the Premier League and both of those were against teams reduced to 10 men. They haven't beaten a side with a full complement since Liverpool in March.
Sebastien Bassong scored his second Norwich goal eight days after his first, while Phil Bardsley, who is Sunderland's third-highest appearance-maker in the Premier League edged a little closer to closer to second-placed Kevin Phillips. He's now on 136 and Phillips is on 139. The one out in front - but catchable if Sunderland stay up - is Michael Gray on 170.
Dear Martin, Have we ever seen seven goals scored in a quicker time than the 34 minutes it took Reading and Manchester United on Saturday? That surely hasn't happened before in the Premier League? Keep up the good work, Scott (Crystal Palace fan)
MARTIN SAYS: Saturday's amazing game at the Madejski is only the third match in Premier League history to see seven first-half goals - and as you suggested, the seventh goal scored by Robin van Persie came in the 34th minute.
The last time we saw seven goals in the first half of a Premier League game was April 21, 2000 when Bradford hosted Derby. Rory Delap, Branko Strupar and Craig Burley all scored for Derby, while Peter Beagrie and a Dean Windass hat-trick saw Bradford lead 4-3 at half-time (it eventually finished 4-4). However, Windass scored the seventh goal of the game in the 44th minute - 10 minutes later than Saturday.
But I can confirm that we HAVE seen seven goals scored in a quicker time in a Premier League game. When Blackburn hosted Leeds on September 14, 1997 the away side were 4-2 up with only 23 minutes on the clock.
Martin Dahlin pulled one back for Blackburn in the 33rd minute - which means that this game saw seven goals a minute quicker than in Saturday's clash - and like that game, the score remained at 4-3 to the away side for the rest of the match. I've detailed that game below:
14/09/1997: Blackburn [Kevin Gallacher (8) Chris Sutton (pen 16) Martin Dahlin (33)] 3 - 4 Leeds [Rod Wallace (3, 17) Robert Molenaar (6) David Hopkin (23)]
I'll never forget that game because I was commentating on it for Sky Sports and it was my birthday. I said at half-time what a good birthday present it was but I think I jinxed the second half because there were no more goals!
Hi Martin, With Man United winning 1-0 against West Ham on Wednesday, I wanted to know what is the earliest winning goal scored. We know there are early goals - ie within the first minute - but I don't think many of those games ended 1-0. So with the score 1-0, what is the earliest that the winning goal was scored? Sean (Man United fan)
MARTIN SAYS: According to our records, Robin van Persie's strike was indeed the quickest winning goal in Premier League history. We've found evidence of three games that finished 1-0 with the only goal being scored inside the first minute, however, in the other two fixtures the scoring took longer to be opened than the 33 seconds that van Persie needed against West Ham.
Interestingly, the second quickest winning goal in Premier League history was also scored by Manchester United; Wayne Rooney scored in the 54th second against Wigan at Old Trafford in 2009 and the match finished 1-0.
The third quickest winner also involved Wigan - and remarkably involves their first ever Premier League goal. In only their third game in the top flight, Jason Roberts was fouled by Sunderland's Gary Breen inside the penalty area after only 12 seconds - and the Wigan striker picked himself up to convert the resulting penalty kick. Our records indicate the goal was scored in the 55th second, even though the penalty was awarded much sooner.
The earliest winning goals in Premier League history:
28/11/2012: Manchester United 1-0 West Ham (Robin van Persie, 33 seconds)
14/01/2009: Manchester United 1-0 Wigan (Wayne Rooney, 54 seconds)
27/08/2005: Wigan 1-0 Sunderland (Jason Roberts, pen, 55 seconds)
20/03/1996: Southampton 0-1 Sheffield Wednesday (Marc Degryse, 65 seconds)>
Hi Martin. I was watching the Liverpool match against Spurs and I could not believe that Phil Dowd did not award Luis Suarez a penalty when William Gallas tripped him. This also means that Liverpool have not won a penalty this year. So my question to you is what is the longest run that a team has not won a penalty in the Premier League? Mark Dilworth (Liverpool fan)
MARTIN SAYS: Liverpool's last penalty came in the penultimate game of last season when they were awarded one against Chelsea (although Stewart Downing failed to convert it). They have played 16 Premier League games since then (one to end last season and 15 this) without a penalty.
There are five other teams who haven't been awarded a penalty yet this season, including Tottenham who are also on a 16-match run without a spot kick. The other four teams are on an even longer run without a penalty:
Norwich are currently on a 23 game run. Their last spot-kick was against Wolves in March.
Swansea are without a spot-kick in 25 games. Against Man City in March was the last time they had one.
Sunderland also haven't had a penalty in 25 games. Their last penalty was against Newcastle in March.
Aston Villa are currently on a 31 game run without a penalty. Their last penalty was against Wolves in January.
However, they are nowhere near Opta's record for consecutive Premier League matches without being awarded a penalty. They have only been keeping penalty data since the start of the 1998/99 season and Wimbledon hold the record in that period with 65 games without a penalty - but we've researched further back than that and discovered that the run actually extends to 91 matches without a spot kick.
They were awarded one against Leeds on October 25 1997 and went through the rest of the season and the whole of the next season without winning a penalty. The run ended when they were awarded one against Leicester City on March 11, 2000 and Neil Ardley scored from the spot.
Four other teams have been on runs of more than 50 matches without being awarded a penalty. They are detailed below:
Longest Premier League runs without penalty kicks (from start of 1998/99 season):
|Games without penalty
|Date of last match
|Penalty given against
|Leicester City 11/03/00
|Manchester City
|Liverpool 03/05/03
|Blackburn Rovers
|Manchester City 13/11/04
|Southampton 11/01/03
|Middlesbrough 29/09/01
*Actually part of a 91-game run (Opta's data only goes back to start of 1998/99)
So Liverpool's run isn't that long, but then again they had a terrible record on penalties last season anyway. They only scored one of six in the Premier League (Charlie Adam v West Brom) and had the following misses: Suarez v Sunderland, Kuyt v Everton, Adam v Wigan, Kuyt v Arsenal, Downing v Chelsea. What's the point in having them if you don't score them?
Hi Martin, love your work. My question is regarding 0-0 draws. After seeing Rafael Benitez preside over another stalemate in his second game in charge of Chelsea, it got me wondering. He must be approaching thirty 0-0 draws as a Premier League manager - who has the most? Martin Frankland
MARTIN SAYS: Opta have looked into this for you and have confirmed that the manager who has presided over the most goalless draws in Premier League history indeed took a new job at a West London club within the past fortnight - but it's not the man you were thinking of. Harry Redknapp has taken charge of 59 Premier League goalless draws in his career - which is 10 more than anybody else.
Next on the list is Arsene Wenger (49 goalless draws), followed by Sir Alex Ferguson (45 goalless draws) - although that's hardly surprising given that they've taken charge of more games than anybody else. Rafeal Benitez has overseen 27 Premier League goalless draws to date.
Most Premier League goalless draws:
Harry Redknapp (59)
Arsene Wenger (49)
Alex Ferguson (45)
George Graham (45)
Sam Allardyce (33)
Steve Bruce (33)
Martin O'Neill (32)
Alan Curbishley (30)
Gordon Strachan (29)
David Moyes (27)
Joe Kinnear (27)
Rafael Benitez (27)
However, you've got to consider the longevity of the managers. Harry Redknapp's 59 goalless draws have come in 595 Premier League games - an average of a 0-0 draw every 10.1 games. That contrasts with Wenger (one every 12.6 games), Ferguson (one every 17.5 games), Graham (one every 6.4 games), Allardyce (one every 10.2 games), Bruce (one every 9.6 games), O'Neill (one every 10.7 games), Curbishley (one every 10.9 games), Strachan (one every 9.3 games), Moyes (one every 15.0 games), Kinnear (one every 11.2 games) and Benitez (one every 8.6 games)
So from our list you're most likely to see a 0-0 draw when George Graham is in charge - followed by Benitez.
Hi Martin, I love all your stats and facts. With the appointment of Rafa Benitez, everybody is talking about the amount of managers Chelsea have had in the past few seasons. What I am wondering is which player has been managed by the most managers in Premier League history? Thanks, Chris
MARTIN SAYS: The clever chaps at Opta have been hard at work on this question and they've managed to calculate that there are five players in Premier League history to have served under 15 managers (when caretakers are included) - and one of those players actually served under 16 managers!
That man is Aston Villa goalkeeper Shay Given, who is currently working under his 16th Premier League manager in Paul Lambert. He has made 440 Premier League appearances for Blackburn, Newcastle, Manchester City and Aston Villa and has worked under the following bosses (the number in brackets is the number of Premier League appearances for that manager).
Bobby Robson (166)
Graeme Souness (54)
Glenn Roeder (36)
Alex McLeish (32)
Mark Hughes (32)
Ruud Gullit (29)
Kenny Dalglish (26)
Roberto Mancini (18)
Joe Kinnear (16)
Sam Allardyce (13)
Kevin Keegan (8)
Nigel Pearson (2)
Chris Hughton (3)
Tony Parkes (2)
Paul Lambert (2)
John Carver (1)
Four further players have played under exactly 15 managers. Those players are as follows:
DAMIEN DUFF: Roy Hodgson (70),Graeme Souness (58), José Mourinho (58), Martin Jol (40), Mark Hughes (24), Claudio Ranieri (23), Glenn Roeder (22), Joe Kinnear (18), Brian Kidd (15), Kevin Keegan (13), Alan Shearer (8), Sam Allardyce (4), Chris Hughton (2), Tony Parkes (2), Nigel Pearson (1)
MARCUS BENT: David Moyes (55), Mickey Adams (33), George Burley (25), Steve Bruce (21), Alan Pardew (16), Alan Curbishley (13), Iain Dowie (9), Graeme Souness (9), Chris Hutchings (8), Steve Coppell (7), Attilio Lombardo (6), Les Reed (5), Ron Noades (3), Mick McCarthy (3), Frank Barlow (2)
NICK BARMBY: Walter Smith (61), Bryan Robson (42), Phil Brown (38), Osvaldo Ardiles (37), Gerard Houllier (32), Howard Kendall (30), Gerry Francis (27), Doug Livermore (22), Joe Royle (19), Terry Venables (16), Dave Watson (6), Eddie Gray (5), Peter Reid (4), Iain Dowie (3), Steve Perryman (1)
STEPHEN CARR: George Graham (85), Alex McLeish (73), Glenn Hoddle (43), Gerry Francis (40), Graeme Souness (32), Glenn Roeder (30), Christian Gross (27), David Pleat (26), Sam Allardyce (5), Bobby Robson (4), Kevin Keegan (4), David Pleat (4), Nigel Pearson (2), John Carver (1), Osvaldo Ardiles (1)
Out of interest, Luke Young, Andy O'Brien, Sol Campbell and James Milner have all played for 14 managers - it seems that Newcastle United, rather than Chelsea, are the thread between players with the most Premier League managers.


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text:
Crude oil seems to record its biggest hike in price almost monthly and gas prices appear to hit record levels almost daily. I'm sure that Google Maps mashups that show the consumer where they can find the cheapest gas are bound to be popular at the moment.
GasPriceWatch is a website that will help you find the cheapest gas prices in your neighbourhood. You can search GasPriceWatch for US gas prices by using the zip code search or by specifying a street, city and state. The gas prices of local gas stations are then shown in a sidebar and tagged on the map.
Gas Prices are updated on the site by over 123,000 volunteers.
GasBuddy have a handy Google Maps mapplet that will allow you to search Google Maps for the cheapest gas prices. The cheapest stations are tagged on the map showing the price, address and time and date when the current price was updated
ALtFuelPrices is a Google Maps mashup showing alternative fuel prices and fill stations for the entire US. You can search the map by zip code or state. You can also refine your search by type of fuel, e.g. biodiesel or electric.
Results are returned on the map with handy price tags.
UK Readers can find the cheapest petrol in their neighbourhood at WhatGAS.com. Search for prices by entering a postcode in a search box. Local petrol stations are then tagged on the map with prices in litres. You can even adjust / update the prices yourself if you know they are wrong.
WAPetrol is a Google Map mashup showing the cheapest places to buy petrol in Western Australia. The cheapest prices are given in a sidebar. Click on one of the petrol stations listed in the sidebar and it is highlighted on the map.
What do you know - it seems lifehacker thought that today would be a good time to post on 'Easy Ways to Save Money on Gas'. Not particularly Google Maps related but definitely on topic - and some handy tips.
Use Public Transport
Finally - whilst this is not exactly a trick to find cheap gas - using public transport, where you can, will probably save you money in the long run. When you ask for directions in Google Maps check for the Public Transit option. Google Maps for Mobile also recently added public transportation directions.
Previously Featured Gas Price Maps:
"Cheap-Gas" Google Maps mashup - the Catskill and Hudson Valley region of New York State.
Cheap Gas Google Maps widget - USA
ShowMeTheMap.com - Ottawa
Pumps.ie - Ireland


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- Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA (2012)
- Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H/ACA box snoRNAs and C/D box snoRNAs, respectively. Furthermore, rRNAs of both ribosomal subunits also contain various base modifications, which are catalysed by specific enzymes. These modifications cluster in highly conserved areas of the ribosome. Although most enzymes catalysing 18S rRNA base modifications have been identified, little is known about the 25S rRNA base modifications. The m(1)A modification at position 645 in Helix 25.1 is highly conserved in eukaryotes. Helix formation in this region of the 25S rRNA might be a prerequisite for a correct topological framework for 5.8S rRNA to interact with 25S rRNA. Surprisingly, we have identified ribosomal RNA processing protein 8 (Rrp8), a nucleolar Rossman-fold like methyltransferase, to carry out the m(1)A base modification at position 645, although Rrp8 was previously shown to be involved in A2 cleavage and 40S biogenesis. In addition, we were able to identify specific point mutations in Rrp8, which show that a reduced S-adenosyl-methionine binding influences the quality of the 60S subunit. This highlights the dual functionality of Rrp8 in the biogenesis of both subunits.
- Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in "Saccharomyces cerevisiae" (2013)
- The 25S rRNA of yeast contains several base modifications in the functionally important regions. The enzymes responsible for most of these base modifications remained unknown. Recently, we identified Rrp8 as a methyltransferase involved in m1A645 modification of 25S rRNA. Here, we discovered a previously uncharacterized gene YBR141C to be responsible for second m1A2142 modification of helix 65 of 25S rRNA. The gene was identified by reversed phase–HPLC screening of all deletion mutants of putative RNA methyltransferase and was confirmed by gene complementation and phenotypic characterization. Because of the function of its encoded protein, YBR141C was named BMT2 (base methyltransferase of 25S RNA). Helix 65 belongs to domain IV, which accounts for most of the intersubunit surface of the large subunit. The 3D structure prediction of Bmt2 supported it to be an Ado Met methyltransferase belonging to Rossmann fold superfamily. In addition, we demonstrated that the substitution of G180R in the S-adenosyl-l-methionine–binding motif drastically reduces the catalytic function of the protein in vivo. Furthermore, we analysed the significance of m1A2142 modification in ribosome synthesis and translation. Intriguingly, the loss of m1A2142 modification confers anisomycin and peroxide sensitivity to the cells. Our results underline the importance of RNA modifications in cellular physiology.
- Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae (2013)
- RNA contains various chemical modifications that expand its otherwise limited repertoire to mediate complex processes like translation and gene regulation. 25S rRNA of the large subunit of ribosome contains eight base methylations. Except for the methylation of uridine residues, methyltransferases for all other known base methylations have been recently identified. Here we report the identification of BMT5 (YIL096C) and BMT6 (YLR063W), two previously uncharacterized genes, to be responsible for m3U2634 and m3U2843 methylation of the 25S rRNA, respectively. These genes were identified by RP-HPLC screening of all deletion mutants of putative RNA methyltransferases and were confirmed by gene complementation and phenotypic characterization. Both proteins belong to Rossmann-fold-like methyltransferases and the point mutations in the S-adenosyl-L-methionine binding pocket abolish the methylation reaction. Bmt5 localizes in the nucleolus, whereas Bmt6 is localized predominantly in the cytoplasm. Furthermore, we showed that 25S rRNA of yeast does not contain any m5U residues as previously predicted. With Bmt5 and Bmt6, all base methyltransferases of the 25S rRNA have been identified. This will facilitate the analyses of the significance of these modifications in ribosome function and cellular physiology.
- Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1 (2015)
- The function of RNA is subtly modulated by post-transcriptional modifications. Here, we report an important crosstalk in the covalent modification of two classes of RNAs. We demonstrate that yeast Kre33 and human NAT10 are RNA cytosine acetyltransferases with, surprisingly, specificity toward both 18S rRNA and tRNAs. tRNA acetylation requires the intervention of a specific and conserved adaptor: yeast Tan1/human THUMPD1. In budding and fission yeasts, and in human cells, we found two acetylated cytosines on 18S rRNA, one in helix 34 important for translation accuracy and another in helix 45 near the decoding site. Efficient 18S rRNA acetylation in helix 45 involves, in human cells, the vertebrate-specific box C/D snoRNA U13, which, we suggest, exposes the substrate cytosine to modification through Watson–Crick base pairing with 18S rRNA precursors during small subunit biogenesis. Finally, while Kre33 and NAT10 are essential for pre-rRNA processing reactions leading to 18S rRNA synthesis, we demonstrate that rRNA acetylation is dispensable to yeast cells growth. The inactivation of NAT10 was suggested to suppress nuclear morphological defects observed in laminopathic patient cells through loss of microtubules modification and cytoskeleton reorganization. We rather propose the effects of NAT10 on laminopathic cells are due to reduced ribosome biogenesis or function.
- Partial methylation at Am100 in 18S rRNA of baker's yeast reveals ribosome heterogeneity on the level of eukaryotic rRNA modification (2014)
- Ribosome heterogeneity is of increasing biological significance and several examples have been described for multicellular and single cells organisms. In here we show for the first time a variation in ribose methylation within the 18S rRNA of Saccharomyces cerevisiae. Using RNA-cleaving DNAzymes, we could specifically demonstrate that a significant amount of S. cerevisiae ribosomes are not methylated at 2′-O-ribose of A100 residue in the 18S rRNA. Furthermore, using LC-UV-MS/MS of a respective 18S rRNA fragment, we could not only corroborate the partial methylation at A100, but could also quantify the methylated versus non-methylated A100 residue. Here, we exhibit that only 68% of A100 in the 18S rRNA of S.cerevisiae are methylated at 2′-O ribose sugar. Polysomes also contain a similar heterogeneity for methylated Am100, which shows that 40S ribosome subunits with and without Am100 participate in translation. Introduction of a multicopy plasmid containing the corresponding methylation guide snoRNA gene SNR51 led to an increased A100 methylation, suggesting the cellular snR51 level to limit the extent of this modification. Partial rRNA modification demonstrates a new level of ribosome heterogeneity in eukaryotic cells that might have substantial impact on regulation and fine-tuning of the translation process.


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Baseball Program
Bossier Parish Community College is a member of the National Junior College Athletic Association. The athletic program at BPCC, which is an integral part of the institution, fosters the College's mission of instruction and service. BPCC competes in three collegiate sports: men's baseball, men's basketball, and women's softball. BPCC also has one intramural sport: women's basketball. For more information about intercollegiate sports, students should contact the Athletic Department.
Open Tryouts
June 8 and June 30


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Narrow your search
Controversial service had faced paying damages of hundreds of millions of dollars in copyright infringement lawsuit filed by record labels.
US revenue from streaming services like Pandora, Spotify and Apple's Beats eclipsed sales of CDs last year, according to data from the music industry's trade group.
Some consumers accused Apple of unfairly boosting iPod prices because it banned music from services other than the iTunes store. They're asking for $350 million, and even Steve Jobs will make an appearance in court, via taped deposition.
Music's bedrock business will be selling access to streams, not ownership of tunes. So what does that mean for the artists you love? It should be music to their ears.
Singer received less than $500,000 in the past 12 months for US music streaming, label tells Time magazine.
Google's popular video site rolls out its long-teased contender in the paid streaming-music business. Called Music Key, it may have the best chance yet to popularize music subscriptions.
Spotify's Daniel Ek says the world's top subscription streaming-music service added 2.5 million paying members in fewer than six months and has returned a total of $2 billion to the music industry.
Revenue for digital music held steady in the first half of the year, but streaming services appeared to get richer at the expense of downloads, according to data from the RIAA.
Every iTunes customer -- more than 500 million people, but who's counting? -- get the band's new album free in what CEO Cook calls the largest record release in music history.
Commentary: EFF's Parker Higgins explains why a federal appeals court decision has knocked out the underpinnings of the business model used by copyright trolls.


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WEST MADISON – It was a wonderful day with a homecoming parade through town and when game time rolled around thousands packed the stands in what appeared to be the largest crowd in Scott football history.
The Class AA game featured the undefeated No. 1 ranked Scott Skyhawks at home against the undefeated No. 3 ranked Wayne Pioneers.
"Since about 2003 we've set out to build a pretty consistent program," Scott Coach Shane Griffith said prior to the game. "One of the teams we looked to in building our team is Wayne. The Pioneers play hard and are consistently one of the top programs in the state."
On the second play of the game, a Wayne running back got outside and around the Scott defense for an 80-yard touchdown run. That long run was just the beginning of several big plays by the Pioneers in a dominating 47-6 win over the Skyhawks.
The Cardinal Conference matchup was a hard hitting game with both teams having players injured during the game.
Scott's only touchdown came on a Robert Bias pass to Dylan Dehart.
Skyhawk runningback Cameron Loftus ran hard and played well on defense, but the team just couldn't get any momentum throughout most of the game. Tryston Crone also played well on defense.
Loftus had 44 yards on 13 carries to lead the team in rushing. Scott only passed for 15 yards in the game.
Wayne improves its record to 6-0 on the season, while Scott drops to 6-1. Both teams appear to have Class AA playoff spots wrapped up and could meet again down the road.
The Skyhawks will travel to Herbert Hoover High School this Friday night, Oct. 12, to take on the Huskies in another Cardinal Conference matchup.
The Huskies go into the contest with a record of 1-6. Hoover lost 27-20 in their recent league contest against Sissonville.
The game will be live on the radio on WZAC 92.5 FM with the pre-game show starting at 7 p.m.


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Marriage is more than a piece of paper. It's a framework designed to facilitate giving you the best possible experience in a committed relationship. read more
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BKE Extra Long & Lean Tank Top
$14.00 Item #55460UN780F11
- Basic tank
- Body length 28 3/4" on size medium
- 95% Cotton, 5% Spandex.
- Machine wash cold water with like colors. Use only non-chlorine bleach. Reshape when wet, lay flat to dry. Low iron if needed.
- Made in Canada.
Have a Question?
Email Guest Services.
- Body length 28 3/4" on size medium.
BKE Extra Long &Lean Tank Top 3 3
My every day wear I literally wear one of these tanks every day and I have for years, whether going to work or staying home. They are soft, fitted, stretchy and long which makes them perfect to smooth me a bit. They add a layer for warmth and a splash of color. I'm curvy and 50 so I need the XL. I just wish they offered more deep colors in XL online. February 26, 2014
Necessity for layering I have this tank in many colors, and it's the best layering tank! It's a tight fit that makes it great under any kind of other top or sweater. It washes up great and they last a long time - a great buy! January 6, 2013
bke extra long and lean tank i accidentally came across this site while doing a google ssearch for long tanks. This tank is SO AWESOME and the price is SO RIGHT its almost unbelievable!!! I bout just two at first and when I realized how great the fit and feel was I reordered two in each color I liked. I wear them under everything daily. Washer and dryer friendly too Such a good staple for my wardrobe and priced so well I will probably be ordering more again! January 5, 2013
1-3 of 3


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Hiroshima and Nagasaki Photo Gallery and related media
Hiroshima and Nagasaki
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|Sr. (C)
|Hanover, Mass.
|High School:
|Thayer Academy
|Business Administration: Management
The son of Kenneth and Deborah Evans... born 7-25-89 in Hanover, Mass.
2012 Statistics
Selected to play in East-West Shrine All-Star Game... named to College Sporting News Fabulous 50... named ECAC D-I FCS All-Star... named Walter Camp Football Foundation All-America ford third time... tabbed to A.P. All-America Team... named to AFCA FCS Coaches' All-America Team... garnered The Sports Network FCS All-America honors for second year in a row... named to All-New England Team for second straight year... tabbed to Beyond Sports Network All-America Second Team... named to All-CAA First Team for second straight season… named CAA Defensive Player of Year and All-America Second Team by College Sports Madness… league leader in total tackles (115) and solo tackles (77) and ranked second in tackles/game (10.5)… UNH's all-time leader with 449 career tackles and active FCS leader in career tackles and career solo tackles (266)… made it five straight double-digit tackle performances with 12 stops, eight solo, in loss to Towson on Nov. 17; sixth straight week he led team in tackles and ninth time in 11 games… became UNH's all-time tackle leader during Nov. 3 victory over William & Mary on Nov. 3… led team with 10 tackles (fourth straight double-digit tackle game) and passed Steve Doig (434 career tackles) with eighth tackle of afternoon… racked up third straight double-digit tackle effort with team-leading 12 stops in win at Rhode Island on Oct. 27... notched second straight double-digit tackle game with team-high 11 tackles at Maine on Oct. 20... named CFPA Linebacker Performer of Week Honorable Mention after collecting season-high 16 tackles -15 solo- in Homecoming win vs Richmond on Oct. 13... led squad with six tackles, five solo, in Oct. 6 win at Georgia State… registered nine tackles in win over Delaware on Sept. 29... made 12 tackles in loss at Old Dominion on Sept. 22... led team in tackles in first three games, with nine tackles in each contest... moved into second place on school's all-time tackle list with 361 by notching nine stops in win over Central Connecticut State on Sept. 15... named CFPA Linebacker Performer of Week Honorable Mention after Minnesota game Sept. 8; tied for team lead (w/ Alan Buzbee) for second straight week by registering nine tackles, including career-high two sacks, in loss at Minnesota... tied Chris Beranger for team lead by registering nine tackles, eight solo, in win at Holy Cross... named CAA Preseason Defensive Player of Year and to Preseason All-Conference Team... tabbed to 2012 Buck Buchanan Award Watch List... named to The Sports Network Preseason All-America First Team... named Phil Steele's Preseason CAA Defensive Player of Year, All-America First Team, All-CAA First Team and No. 2 preseason inside linebacker nationally... named to Beyond Sports Network Preseason All-American Team... named to College Sporting News Preseason All-America First Team... named College Sports Madness Preseason All-America First Team and CAA Defensive Player of Year... tabbed to College Sports Journal Preseason All-America First Team... placed on CFPA Linebacker Award Watch List... elected as team co-captain
2011 Statistics
Buck Buchanan Award winner as national defensive player of year... Walter Camp Football Foundation All-American... Phil Steele's All-America First Team... The Sports Network/Fathead.com All-America... College Sports Madness All-American... Beyond Sports College Network National Defensive Player of the Year... College Football Performance Awards Elite Linebacker Award... A.P. All-America Second Team... Gold Helmet Award as New England's FCS Player of the Year... All-CAA First Team... All-New England Team... received CAA Commissioner's Academic Award... led nation with 7.67 solo tackles/game and ranked second in country with 165 total tackles, the second-most in UNH single-season history... amassed double-digit tackles in 10 of 12 games... garnered Beyond Sports Network Defensive Player of Week award after Nov. 12 Towson game... named CFPA LB Performer of Week after Nov. 5 James Madison game... earned CAA Defensive Player of Week, College Sporting News All-Star and Beyond Sports Network Defensive Player of Week award following Oct. 22 UMass game... received honorable mention as CFPA Linebacker Performer of Week after Sept. 24 Richmond game... named CAA Defensive Player of Week and Beyond Sports Network Defensive Player of Week for performance in Sept. 10 game at Lehigh... started all 12 games at MLB... led team with 165 tackles and 86 unassisted tackles... added 3 interceptions for team-leading 102 INT-return yards and 2 pick-sixes... posted 7.5 tackles for loss, including 2 sacks, 3 pass breakups, 3 forced fumbles, fumble recovery and 2 QB hurries... collected 11 tackles and returned INT 58 yards for a TD in NCAA second-round playoff loss at Montana State... made 12 tackles in win over Maine... notched team-best 19 tackles, including a sack, in loss at Towson... paced team with 17 tackles, including a sack, a forced fumble and a fumble recovery in win vs James Madison... registered 9 tackles and an interception in win over Rhode Island... made team-high 13 tackles, forced 2 fumbles and recorded a pass breakup in Colonial Clash win over UMass at Gillette Stadium... tallied 13 tackles in loss at William & Mary... posted 8 tackles in win over Villanova... made 11 tackles in win over Holy Cross... made 14 tackles and notched 31-yard pick-six in win at Richmond... set career highs with 24 tackles and 17 solo stops in win at Lehigh... led team with 14 tackles in loss at Toledo... named to College Sporting News Preseason All-America Team... selected to Preseason CAA All-Conference Team... tabbed to The Sports Network/Fathead.com Preseason All-America First Team... named to Phil Steele's Preseason All-American First Team and Preseason All-CAA Team... named to preseason Buck Buchanan Award Watch List... tabbed to CFPA D-I FCS Watch List... named College Sports Madness Preseason All-America First Team
2010 Statistics
Named College Sporting News Sweet-63 All-America... named to All-CAA Second Team... named to The Sports Network/Fathead.com All-America Second Team... named to A.P. All-America Second Team... named Walter Camp FCS All-America... finished fourth in voting for Buck Buchanan Award... named CAA Defensive Player of the Week three times (Oct. 18, 25, Nov. 22)... won weekly Gold Helmet Award (Oct. 20)... named ECAC Defensive Player of Week (Oct. 18)... ranked third in FCS D-I football with 156 tackles, the second-highest single-season total in UNH history... was the Wildcats' leader in tackles in nine of 13 games, notched double-digit tackles 11 times and set a career high with 20 stops Nov. 6 versus William & Mary... in addition to pacing team with 156 tackles, also led in unassisted stops (79), finished second with four sacks, 10.5 tackles for loss; added two interceptions, returning one for TD (vs. Towson, Nov. 20), secured two fumble recoveries and three forced fumbles...posted team-high 11 tackles, with one sack, in NCAA D-I quarterfinal loss at No. 5 Delaware... collected team-leading 10 tackles in NCAA second-round playoff win at No. 13 Bethune-Cookman... made 7 tackles, forced a fumble and recorded a 25-yard pick-six in win over Towson... led team with 15 tackles in win at No. 9 Villanova... posted career-high 20 tackles in loss to No. 4 William & Mary... led squad with 13 tackles, forced a fumble and registered an interception in victory over UMass at inaugural Colonial Clash, earning the Bill Knight Trophy as game's MVP... notched team-high 14 tackles, with one sack, a fumble recovery and a forced fumble in upset win at No. 6 James Madison... tied for team lead with 12 tackles, including a sack and a fumble recovery, in homecoming win over No. 11 Richmond... amassed 12 tackles, including 2.5 for loss and a half sack, in loss at Maine... totaled 10 tackles in win over Lehigh... paced team with 11 tackles in loss at Rhode Island... made 7 tackles in loss at Pittsburgh... recorded team-leading 14 tackles, including a half sack, in season-opening victory over Central Connecticut State
2009 Statistics
Played in 12 games for the 'Cats...racked up 13 tackles, including eight solo efforts...tallied multiple tackles in three games...notched a career-high three tackles against Dartmouth (Sept. 26)...recovered one fumble
Redshirt season
Career Highs:
Solo 17, at Lehigh, 2011
Assist 11, vs W&M, 2010
Total 24, at Lehigh, 2011
Sacks 2.0, at Minnesota, 2012
Interceptions 1, 5x, last at Montana State, 2011
notes: at Richmond, 2011 (31-yard TD)
vs Towson, 2010 (25-yard TD)
at Montana State, 2011 (58-yard TD)
Fumbles Forced 2, at UMass, 2011
Fumbles Rec. 1, 3x, last vs James Madison, 2011
note: at James Madison, 2010 (17-yd TD return)
Before UNH
Lettered in football, lacrosse and basketball at Thayer Academy...totaled 72 tackles, four sacks, three forced fumbles and one interception during his senior season...on offense, rushed for 827 yards and 12 touchdowns...named to the Super 26 All-State team...a two-time All-Scholastic Patriot Ledger selection...an All New England selection...named to the Shriner All-Star game