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|81 posts found
Originally posted by botrytis
I don't even know that's true. The problem with the pro-groupers is they simply refuse to acknowledge that the genre and it's playerbase has changed over the years, they think that it's possible to reset things and it will go back to the way it used to be.
The reality is, back in the day of UO and EQ, the majority of people playing MMOs were the geeks and the nerds, they were the only ones that had access to high-end machines and broadband Internet. Therefore you already had a group of people who fundamentally had a lot in common outside of playing the game. It wasn't horrible to get caught with nothing to do once in a while because no matter who you were with, you probably had something to talk about. There probably wasn't a group I was in back then that couldn't quote Monty Python and the Holy Grail from memory. There was an actual community because virtually everyone playing the game belonged to the same social group.
Enter the broadband explosion and now *EVERYONE* has access to these games. Instead of one single unified community, you have dozens, even hundreds of different communities with different interests, different tastes, different goals. Nobody wants to get caught in these uncomfortable silences caused by downtime because they have nothing in common with the people they are playing with, except for the game. That's why people started playing solo because it avoided those uncomfortable encounters. Everyone played for their own purposes and their own goals and if they could hook up with a couple of people who shared their interests and were on at the same time, great. If not... you played alone. Games changed to reflect this new reality.
The fact is, even if you did go back to forced grouping, you'll never go back to the same feeling of community that games once had. Those days are simply gone, at least unless you restrict games to a single social group, which no one is going to do. I'm sure people want to be social, they just want to do it with people that they share common interests with. It's just not that easy to come by in modern games, or in modern online life.
Played: UO, EQ, WoW, DDO, SWG, AO, CoH, EvE, TR, AoC, GW, GA, Aion, Allods, lots more
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Advanced Member
Joined: 12/21/07
Originally posted by Arclan
Yeah .. the drop rate has nothing to do with the system. The private loot system is designed to do away with ninjaing, and loot drama. There is zero of those in D3, and WOW LFR.
The drop rate, obviously need to be tweaked based on progression curve and stuff like that. And you can run the same system with low drop rate or very high ones.
Advanced Member
Joined: 12/04/12
Originally posted by Alberel
Hard Core Member
Joined: 1/29/07
"Ideas are worthless. The only currency that holds any weight is the ability and drive to execute."
Wait, are you suggesting now the 'cool' people are playing MMOs? Kinda funny. I've never met a cooler group of people than I did in EQ around 1999. Met several of them IRL; all cool, good looking, successful people with personalities. I was shocked.
Gaming today is different. MMO companies fail to offer gameplay that many vets enjoy; so we aren't playing. What's left are probably mostly folks who like to solo. But just because companies have failed to capture vet's attention, it doesn't mean they should count them (or their money) out. It's a big opportunity for a company that gets it right.
Luckily, i don't need you to like me to enjoy video games. -nariusseldon.
Originally posted by Arclan
Yet for a lot of vets, the only way to "get it right" is to completely throw away 95% of the market in favor of old-school gaming. That's not going to happen and until the vets get it through their heads, nobody is going to make a game that they're going to like.
Played: UO, EQ, WoW, DDO, SWG, AO, CoH, EvE, TR, AoC, GW, GA, Aion, Allods, lots more
Forced interdependance tends to breed more polite behavior simply because people who act in an anti-social fashion get selected against (e.g. do worse). People are therefore acting in thier own enlightened self-interest by being nice to others.
However this does get mitigated to a very large degree when dealing with much larger communities where there are very low odds that you'll ever need to interact with the same people in future.
So if a player is in a game community of 1,000 people and they know they are going to need to interact with those people in future (interdependence), they'll tend not to act like jerks because in the long run they'll be hurting themselves by doing so.
If the same player is in a game community of 100,000 people even with forced interdependance there is not a very strong push to avoid acting like a jerk because the odds of needing to interact with any of those people they are jerks to in future is low...thus not much disincentive.
If there is no forced interdependance then there is no consequence to acting like a jerk whether it's a community of 1,000 or 100,000. There is not much rocket science to it.
Elite Member
Joined: 1/13/10
Currently playing EVE, SMITE, ArcheAge, and Combat Arms
Originally posted by GrumpyMel2
The part of your non-rocket science that you are missing is that you are basing acceptance and rejection on your view of societal norms; views that may or may not be mirrored in the online world you are in. If the norm is speaking in textese, sending group invites without asking first and regularly using profanity, then the polite gentleman is the pariah.
There isn't a "right" or "wrong" way to play, if you want to use a screwdriver to put nails into wood, have at it, simply don't complain when the guy next to you with the hammer is doing it much better and easier. - Allein
Advanced Member
Joined: 1/04/05
Originally posted by Cephus404
During UO - the geeks and nerds only way to socialize was through gaming. Sad but true.
Novice Member
Joined: 1/17/12
Originally posted by Cephus404
Isnt it more a testament to the shallowness and simplicity of the games if players dont feel the need to talk about them and exchange information and opinions about them?
I dont talk politics in clan chat, do you?
Flame on!
The Listener
Joined: 3/04/08
Grouping is an illusion. It's always just you in your basement with your catheter and feeding tubes
Originally posted by Banaghran
There's quite a difference between "I like this game because of X" or "I don't like this game because of Y" and "I hate all games because they aren't catering to a niche audience that I happen to fall into, developers need to make a game for me!"
Played: UO, EQ, WoW, DDO, SWG, AO, CoH, EvE, TR, AoC, GW, GA, Aion, Allods, lots more
Novice Member
Joined: 1/17/12
Originally posted by Cephus404
There is, but what does it have to do with anything, especially people talking about the game INSIDE the game?
Flame on!
Novice Member
Joined: 6/24/06
MMORPG's before 2004 did NOT force grouping. You could still solo, it was just harder, more time consuming, and less efficient to do so..unless you were also doing it for the chance at some lucky loot drop (Depending on the game. Which also depended on how loot tables were distributed in said game).
If you really think about it...games such as WoW and Rift for instance almost force you to solo. Now you CAN group in these games, I know this...but it's tough to get groups unless you join some rabid hadcore raiding Guild...because no one wants to group since you can get almost everything alone, or if you aren't in that clique. No one wants to take the time to talk to others, group up and maybe chat and become friends you put on your friends list and look for for that content that may need some grouping.
At least with more group oriented content MMORPG's people are more likely to group and discover community. AND they STILL have an option to solo at any moment they wish. The other way around, it is MUCH harder to get groups than to solo.
I am not saying there shouldn't be solely group oriented MMORPG's, nor am I saying they should be solely solo oriented ones. They should have the ability to do both. But if anything...they should have a bit more group oriented features to them because to me that provides more of a balance and the option to do one or the other more freely with little or at least less of a wait.
Advanced Member
Joined: 12/21/07
Originally posted by Banaghran
No. Why would i need to discuss endlessly only if a game is deep. Do you discuss endless chess strategy when you are playing chess? Do you discuss endlessly about poker when you are playing Texas Holdem?
Some people may not like to talk .. did that ever occur to you?
Some don't play games to talk about games, you know.
Originally posted by Loktofeit
Well "polite" is clearly subjective to the context of the society it is used in (e.g. in some culture's belching is considered polite in others it is considered rude)....... However, the mores of that subjective context are also going to be heavly influenced on things that objectively harm the individual or groups abilitity to function. For example, it would be very unlikely in a gaming subculture context that spamming another players screen with nonsense or doing a "bad pull" would be considered polite because they objectively harm the individual/groups ability to succeed at tasks that are important in the game.
The principle remains valid. The more a person needs another person and expects to need that person in future, the less likely they are to do things which they expect will cause that person to have a negative opinion of them.
Novice Member
Joined: 5/17/04
An MMO FAN
I'd say neither side of the fence is more douche-like than the other, it's simply as a result of grouping that you are exposed and effected by douche bags.
Much of it depends on personal circumstances. I have always tended to solo. Why? I do not enjoy, nor can i often justify, being virtualy tethered to my keyboard for a protracted period of time. I don't like to keep people waiting, wether they be inside a virtual world or not.
The older days of having to LFG were often not great fun. PUG'ing often resulted/results in being taken in a direction of play that you didn't really want to go in, unless it's for an instance or specific boss etc. If you're not careful you can end up spending an hour clearing some guys quest chain only for him to "soz gotta go byeeee"...
I much prefer, much like a majority of the fanbase/consumers of MMO's, to be able to group up easily and as an option.
currently not playing much...
Elite Member
Joined: 1/13/10
Currently playing EVE, SMITE, ArcheAge, and Combat Arms
Originally posted by GrumpyMel2
You are confusing mores and norms with skill and tactics, or is your assumption that every bad pull is the person intentionally acting like a jerk?
In other words, when in Rome...
There isn't a "right" or "wrong" way to play, if you want to use a screwdriver to put nails into wood, have at it, simply don't complain when the guy next to you with the hammer is doing it much better and easier. - Allein
Hard Core Member
Joined: 9/26/08
"Before I speak, I have something important to say."
Originally posted by Cephus404
Really? The last game I played that forced grouping (FFXI) did quite well. Solo players have hundreds of games to choose from, why begrudge group players 1 game.
"There are certain queer times and occasions in this strange mixed affair we call life when a man takes this whole universe for a vast practical joke, though the wit thereof he but dimly discerns, and more than suspects that the joke is at nobody's expense but his own."
Originally posted by Cephus404
I think you hit upon an interesting point. Obviously people play games for different reasons and everyone does need a certain amount of personal space and "alone time". However, at thier core people are "social animals" which means they do instinctualy want to spend a significant amount of time engaged in social activity (millions of years of hard wired instinct will see to that). However they also have a hard wired anxiety about "strangers". One of the ways this is overcome is when people become less of a stranger due to repeated encounters (i.e. you see the person every day). Another way is when people are purposefully going out of thier way to engage in a certain pre-designated group activity (e.g. "signing up to play baseball/softball".) This breaks a certain amount of the anxiety about the stranger.
Modern games probably work against this in 2 ways. Firstly much larger populations on each "server", meaning less chance of seeing/meeting the same people repeatedly and gaining some familiarty with them that way. Secondly, much broader target audiences and range of activities supported within a single game....e.g. your there to PvE level, I'm there to PvP, Joe's there to explore, Suzy is there to RP, Billy is there to raid/equipment grind, etc. Thus no way to reduce the natural sense of anxiety about strangers by introducing a common built-in assumption about why we are there and want we want to do there.
Originally posted by Loktofeit
No confusion...I'm simply stating that while mores and norms are subjective....they are often strongly influenced by objective factors which effect performance.....and using the hypothetical example that doing a "bad pull" would unlikely to ever become an accepted more because it objectively harms performance.


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The College of Business is committed to teaching excellence in both undergraduate and graduate degree programs. Faculty members are student oriented yet maintain high standards for classroom performance, preparing students for intelligent, active and productive participation in business and community life. West Texas A&M University is accredited by the Southern Association of Colleges and Schools and the College of Business is accredited by the Association to Advance Collegiate Schools of Business (AACSB).
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I was just wondering if following the Brewers diet plan could help prevent PE in a second pregnancy? I got PE very early in my first preg(23 weeks 5 days), and had to deliver and my baby did not survive. And thought mabey if a followed a diet that with high protein(80-100 grams a day), this might help. Is there any proof that this could help. Any input would be greatly appricated.
dd-Natalie 3/10/04(pasted away after 1 hr.) induced labor at 23wks and 5 days due to severe PE/HELLP


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Cook the Book: Radish Salad
Radishes and arugula are two of my go-to salad ingredients—their shared pepperiness always makes for a bright and biting combination that cuts through any rich, fatty flavors in the rest of the meal. The trouble is that when you are dealing with flavors as strong as these, a mustard- or lemon juice-based vinaigrette is sometimes too abrasive resulting in a palate-killing salad. The mother-and-daughter Ortega team (Simone and Inés) have solved the problem by creating a dressing that uses cool and creamy yogurt in place of oil to dress these spicy components. More


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Mark Kendall Interview on KXRA Radio
Mark Kendall was interviewed this morning by Michael Right on KXRA Radio. It will air this Thursday 9/20/12 at 9:00am Central and can be heard on KXRA's website.
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RRS Ernest Shackleton Research Ship Webcam
The webcam on RRS Ernest Shackleton is situated in the Conning Tower (see the Virtual Tour for an image of the Conning Tower). It generally looks forward, but if something of particular interest is going on, it may be moved to look aft or to either side. This is a particularly interesting webcam as (when not on long sea passages) the scenery changes regularly. During the Antarctic summer, it is possible to see stunning polar scenery, icebergs and mountains. During the Antarctic winter, the Shackleton undertakes survey work in the North Sea so you may catch a glimpse of an oil or gas platform. It updates approximately once every hour.
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Take a look at suite-wide enhancements like cloud integration, Touch Mode, PDF editing, and Ribbon customization, as well as individual app improvements added to Office 2013.
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This large, modern hotel is warm and welcoming with elegant charm. Offering great value for money, it is located in the heart of downtown Singapore.
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A semi-active device 20 is provided for damping motion between structures having multi-degrees of freedom. A magnetic field produced by a permanent magnet, a coil, or a combination thereof, change the rheological properties of an MR fluid 40 to effectively lock up the components and the structures to which they are attached to serve as a brake or damper of the associated compound motion. A system 21 employing the MR devices 20 includes a motion detection sensor 15 and a controller 19 to actuate the MR devices 20 when a predetermined motion threshold is exceeded.
1. A magnetorheological device for installation between two structures which have the capacity for relative movement which includes up to six degrees of freedom, said device comprising:
a) a first generally cylindrical metallic element having a first longitudinal axis and a first pair of orthogonal lateral axes, said first cylindrical element including means to secure said first cylindrical element to a first one of said two structures and;
a magnetic core element which has a first radially extending reaction surface positioned inwardly from said first generally cylindrical metallic element;
b) a second generally cylindrical metallic element having a longitudinal axis aligned with said first longitudinal axis and a pair of orthogonal lateral axes coincident, said second with said first or generally element including means to secure said second generally cylindrical, element to a second one of said two structures and;
a plate-shaped magnetic member having a second radially extending reaction surface opposing said first radially extending reaction surface;
c) an elastomeric member secured to each of said first and second generally cylindrical elements and permitting relative movement between said first and second generally cylindrical elements, said first and second generally cylindrical elements primary relative movement being translational movement along said longitudinal axes, said first and second generally cylindrical elements having secondary relative movement in at least one additional direction including translational movement along at least one of said two orthogonal axes and rotational movement about any one of three axes including said longitudinal axis and said two orthogonal lateral axes;
d) a fluid chamber at least partially defined by each of said first and second generally cylindrical elements and by said elastomeric member;
e) a volume of magnetorheological fluid contained within said fluid chamber;
f) a magnetic element for altering a property of said magnetorheological fluid so as to increase a resistance force to, and thereby damp, movement of said first generally cylindrical metallic element relative to said second generally cylindrical metallic element permitted by said elastomeric member;
whereby said relative movement between said two structures can be effectively damped, damping being most effective for said primary movement with a lesser degree of damping for said secondary movement.
2. The device of claim 1 wherein said plate-shaped member is a baffle plate.
3. The device of claim 2 wherein said second cylindrical element comprises a rod member coaxial with and extending longitudinally through said first cylindrical element and said baffle plate is affixed to said rod member.
4. The device of claim 3 wherein said baffle plate further comprises a third reaction surface for engaging said magnetorheological fluid, said third reaction surface opposing a fourth reaction surface formed by another magnetic core element.
5. The device of claim 4 wherein said first generally cylindrical element has a first end closed by said first plateform secured to a first end of said first cylindrical element as by crimping and said elastomeric member comprises an elastomer portion of said plateform bonded to said rod member.
6. The device of claim 5 wherein said first generally cylindrical element has a second end closed by said second plateform secured to a second end of said first cylindrical element as by crimping and said second plateform includes a second elastomer portion bonded to said rod member.
7. The device of claim 1 wherein said magnetorheological fluid is selected from the group consisting of water-based and water/glycol-based magnetorheological fluids.
8. The device of claim 7 wherein the magnetorheological fluid contains at least 45% iron by weight and has at least one of the properties selected from the group consisting of an off-state viscosity of at least 1000 mPa-s and an off-state yield strength greater than 50 Pa.
9. The device of claim 1 wherein said device is configured so that change of said magnetorheological fluid properties and said magnetic fields' relative strength, effectively damps said primary movement and each aspect of said secondary movement.
10. The device of claim 1 wherein said magnetic element comprises an electromagnet which can vary said resistance force between a minimum value and a maximum value.
The present invention is directed to improvements in magnetorheological (MR) fluid devices. More particularly, this invention is directed to semi-active MR fluid devices which are capable of damping motion along/about two or more longitudinal or lateral axes. The devices of this invention can damp motion of a damper or a mount having six degrees of freedom.
Commonly owned U.S. Pat. Nos. 5,277,281 and 5,284,330 describe and claim improvements to dampers involving improved dimensional relationships and sealless damper designs, respectively. The present invention incorporates some of the features of each of those patents and hence each is hereby incorporated by reference. The sealless designs of the present invention are preferably designed to have the dimensional characteristics of the '281 patent while the sealless designs of '330 have been modified to enable damping of multi-degrees of freedom.
MR devices are increasingly being proposed for a variety of uses including dampers, mounts, and tunable vibration absorbers. A number of technical hurdles are preventing implementation of these devices in several of the potentially attractive applications. First, MR fluid is highly abrasive and in dampers where seals are utilized to wipe fluid from a piston rod and retain the fluid within the damper's housing, the fluid quickly finds its way between the seal and piston rod surface and causes rapid deterioration of the seal's integrity.
Another problem which has been encountered is the settling of the iron particles out of the fluid. The MR fluid no longer has the characteristics it was designed to have in that portion of the fluid having reduced particle density nor in that portion having increased particle density.
In addition, most damper designs are configured to combat motion in a single axial direction. Lateral movement or torsional movement has not been a design consideration and, hence, the typical damper is unable to cope with such motion.
The MR device of the present invention overcomes each of these deficiencies of the prior art. Each of the embodiments of the present invention is capable of damping motion in up to six degrees of freedom (three translational and three torsional). Further, in keeping with the development of the '330 patent, by employing a sealless design, one of the key technical hurdles facing implementation of an MR fluid device is overcome. Finally, by utilizing a fluid with a consistency of a gel, the settling problem is overcome. Since the actual stroke length need for these sealless designs is so short, a thicker fluid is actually better. The MR fluid for use in these devices is preferably a water-based or water-glycol based fluid having a) iron loading of at least 45% by weight; b) an off-state viscosity greater than 1 Pa-s; and/or c) an off-state yield strength of at least 50 Pa. Because of the gel-like consistency of this MR fluid, a less expensive, coarser grade of iron can be used.
Various other features, advantages and characteristics of the present invention will become apparent after a reading of the following application.
The accompanying drawings, which form a part of the specification, illustrate several embodiments of the present invention. The drawings and description together, serve to fully explain the invention. In the drawings,
FIG. 1 is a cross-sectional side view depicting a first preferred embodiment of the semi-active MR damper of the present invention;
FIG. 2a is a cross-sectional side view depicting a second preferred embodiment of the semi-active MR damper of the present invention;
FIG. 2b is a side view of the embodiment shown in FIG. 2a;
FIG. 3A is a cross-sectional side view showing a third embodiment;
FIG. 3B is a cross-sectional side view of a fourth embodiment of the present invention;
FIG. 3C is a cross-sectional side view of a fifth embodiment of the present invention;
FIG. 3D is a cross-sectional side view of a sixth embodiment of the present invention;
FIG. 4A is a schematic side view in partial section depicting a first application utilizing the system of the present invention;
FIG. 4B is a schematic side view with portions broken away of a second application for the system of the present invention; and
FIG. 4C is a schematic side view in partial section of a third application for the system of the present invention.
A first preferred embodiment of the device of the present invention is shown in FIG. 1 generally at 20. MR damper 20 includes a generally cylindrical housing 22 which is preferably made of steel. It will be understood that while, for the most part, the terminology of "MR damper" is utilized throughout the specification, the MR devices described herein could also be configured as MR mounts or tuned vibration absorbers. Housing 22 is closed on each end by plateforms 24 which are captured by rolling over ends 26 of housing 22 to engage the metal plate 28 (preferably steel) of plateform 24. Plateform mounts are available from Lord Corporation and are available in a variety of sizes and stiffnesses. Plateforms which are particularly appropriate are identified as Lord Series 100 plateform mounts. Elastomer portions 30 of the plateforms 24 are bonded to metallic spacers 32 which surround opposite ends of through bolt 34. A pair of non-magnetic spacers 36 engage opposed sides of baffle plate 38 retaining it in position on bolt 34.
The bolt-and-baffle-plate assembly 35 functions as a piston moving in fluid 40. A pair of cup-shaped opposite facing members 42 make up the magnetic core receiving therebetween a bobbin wound coil 44. Core members 42 are preferably made of steel. An electrical connector 46 enables coil 44 to produce a magnetic field of a strength proportional to the magnitude of the current. A fill port used for supplying fluid 40 to the assembly is plugged by a pop-rivet 48 capable of sealing the opening. A threaded connector 50 is attached to the end of bolt 32 and extends beyond the end of the bolt providing means to attach the damper to various pieces of equipment requiring its use.
It is here noted that it is preferred that each of the embodiments of this invention be designed to conform to the configurational requirements set forth in commonly assigned U.S. Pat. No. 5,277,281, namely that the ratio of the cross-sectional area of the baffle plate 38 (in this case, the surface area of the plate) Acore to the surface area of the magnetic pole (i.e., one end face of the cup-shaped members 42) Apole, and the ratio of the path area (i.e., transverse cross-sectional area of housing 22) Apath to Apole, are each less than the ratio of the optimum magnetic flux density of the fluid Bopt to the magnetic flux density at which the metal begins to saturate, Bknee.
When the coil is inactive, the fluid 40 can move past baffle plate as a result of movement by bolt 32 axially (longitudinally) in housing 22, laterally (side to side) or vertically within the housing or rotationally about any of these three orthogonal axes. When the coil 44 is activated, however, fluid 40 will become extremely viscous and effectively lock up the piston assembly 35 from moving relative to housing 22. The breakaway force needed to overcome this locking action will be proportional to the strength of the magnetic field and, hence, to the amount of current supplied to coil 44.
A second embodiment of the present invention is depicted in FIGS. 2A and 2B generally at 20a. This embodiment, although significantly different in appearance, operates utilizing substantially the same principles as the FIG. 1 embodiment. Housing member 22a houses coil 44a and a steel pole piece 43a. Cap member 45a, like housing 22a, is also made of steel. Threaded aperture 47a serves as means to connect cap member 45a to one of the two structures subject to vibration isolation. Associated housing 22a may be connected to the other of the two structures by any conventional means including banding, bolting through the base or by inclusion of an attachment flange or the like. Fluid 40a is contained between housing 22a and cap 45a by an elastomeric bladder 30a.
Bladder 30a is connected to housing 22a and to cap 45a by a pair of straps 41a and will permit axial movement, translational movement in two orthogonal directions, and limited rotational movement about any of these three axes. When coil 44a is powered by feeding current through wires 49a, the resultant magnetic field causes the MR fluid 40a to highly damp, or lock up relative movement between housing 22a and cap 45a and between the structures to which they are attached.
FIGS. 3A-3D depict embodiments three through six which are each similar the configuration of the first embodiment. In FIG. 3A, damper 20b is depicted as a mount. Baffle plate 38b is shown as having a lower profile and will, therefore, have less capacity to damp lateral deflections. Non-magnetic spacers 36b are depicted as extending through the elastomeric member 30b which have extension collars 31b which are bonded throughout their lengths to spacers 36b. Attachment bolt 34b is threaded throughout its length and is provided with a hex nut for securing it to one of the two structures with which the mount is to be associated. A large diameter ring nut 52b is threaded into the end of housing 22b to secure pole pieces 42b and coil 44b within housing 22b. While attachment bolts 54b have been shown here as a means of securing the upper plateform 24b to the assembly, rolling of the ends of housing 22b to overlie the edge of metal plate 28b remains the preferred capture technique. Further, ring nut 52b could be configured to partially overlie the edge of the opposite plateform 24b within housing 22b. Openings 21b in flange 23b afford the capability to bolt housing 22b to the second of the two structures for which isolation is sought.
FIG. 3B depicts a fourth embodiment which functions differently than its counterparts. In damper 20c the baffle plate/piston head 38c takes the form of a permanent magnet. Accordingly, the fluid 40c will offer the breakaway force associated with the magnetic field force induced by the permanent magnet and affords no capacity to vary the field strength nor the resistance or locking force. For some applications, this configuration may suffice offering a less costly implementation.
FIG. 3C depicts a fifth embodiment offers a hybrid embodiment useful where the lack of field strength variability is unacceptable in which the baffle plate 38d is a permanent magnet to establish a base magnetic field and a coil 44d is also employed to increase (or decrease, depending upon the polarity of the electromagnet) the strength of the magnetic field acting upon the fluid 40d.
FIG. 3D shows yet a sixth embodiment in which the baffle plate 38e becomes a spool with coil 44e wound thereon. Lead wires 49e are connected to coil 44e through an axial bore 54e in through bolt 34e. As with the previous embodiments, energization of coil 44e will alter the properties of the MR fluid increasing resistance of the fluid 40e to flow through the gap `g` between the edges of baffle plate 38e and the wall of housing 22e. In fact, with the use of sufficient current, the piston assembly 25e will effectively be locked in place relative to housing 22e as has been mentioned with respect to earlier embodiments.
The MR devices 20 of the present invention have several attractive applications in a variety of systems, some of which are described in FIGS. 4A-4C. FIG. 4A depicts a MR damper 20 in accordance with the present invention being used in conjunction with a vibratory trough feeder which is equipped with a scale to measure out an appropriate weight of, for example, candy for packaging. Currently, vibratory tray 60 is suspended by what may be termed a lively suspension 62 above the scales 64 to facilitate vibration for product transfer into a package (not shown). While this suspension facilitates movement of the tray 60, it also can be counter productive in that it takes too long for the tray to settle down to produce an accurate reading on the scale. This not only slows down the packaging process, it can lead to inexact measurements of product resulting in packages which are outside the specified weight range.
The present invention enables the tray 60 to be locked in position during loading for weighing by activating the magnetic coil. When weighing is complete, the coil is deactivated and the vibrator 66 moves the product to the package. The coil 20 will once again be activated and the vibrator 66 inactivated responsive to a sensor which may be a zero reading from the scale 64.
FIG. 4B depicts another potential usage of the semi-active damper system of the present invention. An elevator car is equipped with as many as twelve (four shown) dampers 20 in system 21. Damper system further includes a sensor 15 (i.e., an accelerometer, or alternative velocity or displacement sensor) for detecting movement of elevator car 11. Normally, dampers 20 will be deactivated and guide rollers 13 will glide freely over rails 17 maintained in contact therewith by springs 16. However, when sensor 15 detects motion which falls outside a predetermined permissible range of motion, dampers 20 will be actuated by controller 19 to stabilize the car 11. Controller 19 contains the needed sensor electronics with the embedded algorithm to make the threshold activation determination, as well as the current supply for the dampers 20. While the rails are depicted as planar, they will actually, normally, be angle iron and, hence, the need for two additional sets of four dampers on the front and back of the car 11. The use of the semi-active system 21 of the present invention provides the needed stabilizing force to minimize sway of the passenger car 11 without unduly causing wear on guide rollers 13 by continuously forcing them against the rails 17 which would necessitate frequent replacement of rollers 13.
A third exemplary usage of the semi-active damper system of the present invention is shown in FIG. 4C generally at 21. An isolation table 23 utilizes air pillows 25 to support table 37 on legs 29. An air supply 31 (typically a compressor or bottled air tank) feeds compressed air to air mounts 25 through valves 27 so that sensitive optical instruments and the like, are isolated from the low frequency vibrations produced by HVAC and other sources traveling through the floor of a typical building. Adjustment of the equipment 33 on the table top 37 causes a destabilizing effect that can result in a swaying as the air supply attempts to counter the motion. By incorporating a semi-active system 21 including a damper 20 at each leg 29, a sensor 15 at each air mount 25 and a controller 19 to send electrical current to the respective dampers as needed responsive to the input of sensors 15, the position of the table top 37 can be frozen during equipment adjustment by locking up dampers 20 and then the dampers can be deactivated so the air table 23 resumes normal operation.
With regard to the particulars of the MR fluid useful in this system, utilizing a fluid with a consistency of a gel overcomes the settling problem associated with certain prior art fluids. Since the actual stroke length need for these sealless designs is so short, a thicker fluid is actually better. The MR fluid for use in these devices is preferably a water-based or water-glycol based fluid having iron loading of at least 45% by weight. In addition, the fluid preferably has an off-state viscosity greater than 1 Pascal-second (Pa-s) and/or an off-state yield strength of at least 50 Pa. Because of the gel-like consistency of this MR fluid, a less expensive, coarser grade of iron can be used.
The present invention describes a semi-active device 20 for damping motion between structures having multi-degrees of freedom. A magnetic field produced by a permanent magnet, a coil, or a combination thereof, change the rheological properties of an MR fluid 40 to effectively lock up the components and the structures to which they are attached to serve as a brake or damper of the associated compound motion. A system 21 employing the MR devices 20 includes a motion detection sensor 15 and a controller 19 to actuate the MR devices 20 when a predetermined motion threshold is exceeded.
Various changes, alternatives and modifications will become apparent following a reading of the foregoing specification. It is intended that all such changes, alternatives and modifications as come within the scope of the appended claims be considered part of the present invention.
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We live in a battery-powered world, and the competition to produce reliable, longer lasting batteries for phones, computers and electric vehicles is fierce. Fortunately, US manufacturers are getting a boost from ORNL in the form of the country's largest open-access battery manufacturing research and development facility. The Battery Manufacturing Facility is strategically collocated with both the lab's Manufacturing Demonstration Facility and National Transportation Research Center. The MDF is a state-of-the-art research and development center designed to advance manufacturing technology and give American business a competitive edge in the global market. The NTRC houses much of ORNL's transportation research, from engine development and power electronics to fuel cells and other alternative fuel technologies.
The BMF adds tremendously to ORNL's existing energy storage material processing capabilities, providing scientists with the ability to analyze every aspect of battery production, from raw materials to finished product.
The facility is available to any US battery manufacturer, material supplier or battery user. "The advantage we offer," says Claus Daniel, deputy director of ORNL's Sustainable Transportation Program and scientific head of the facility, "is the ability to integrate any component into a complete battery, analyze the results, and determine how the components can be further improved." The battery manufacturing equipment is modular, so users can "plug-and-play" individual processes, and BMF staff can provide help and guidance every step of the way. "The idea," he says, "is to showcase the user's material or process improvements and to quantify the advantage they provide."
Through the battery facility, Daniel and his colleagues are involved in collaborative R&D with a number of companies, including efforts with battery manufacturer Dow Kokam to develop next-generation materials manufacturing and processing technologies as well as a project with A123 Systems to save energy by reducing heat treatment temperatures and times. The manufacturing facility can produce batteries with capacities up to 7 ampere hours—about seven times that of a cell phone battery. Daniel explains that his group chose that size because it's small enough that a company with limited amounts of material can demonstrate the impact of its innovations, yet large enough to make manufacturing decisions about making larger devices. "If a battery works at that size," Daniel says, "it can be scaled up to whatever size you want—the physics of the battery will be more or less the same."
Not surprisingly, there has been no shortage of interest in the new facility. Daniel explains that, normally, if materials suppliers want to test a new material in a battery, they either have to stand up their own manufacturing facilities—which is cost-prohibitive and takes years—or ally themselves with a specific battery manufacturer, which often means giving the manufacturer exclusive rights to use the material being tested. "This kind of arrangement limits the supplier's ability to disseminate the innovation broadly in the marketplace," Daniel says. "Our facility allows them to keep control of their intellectual property, demonstrate their technology in a complete battery, and benchmark its performance against other commercially available materials. It's all about growing the domestic supply chain for energy storage devices."
Several companies are working on projects at the facility, and procedures are in place to ensure that companies can work at the facility without running the risk of leaking proprietary information to a competitor.
ORNL researchers already had a detailed vision for how they could impact battery manufacturing when they began working with the Department of Energy's Vehicle Technologies Program and Advanced Manufacturing Office sponsors to establish the BMF. The new facility enables scientists and engineers to access every aspect of battery manufacturing with an eye toward improving performance and reducing cost. As a result, many of the facility's projects involve analyzing each step in a battery's production process, looking for the opportunities to boost efficiency.
For example, because certain battery components need to be moisture-free when they are assembled, they are dried once after they're manufactured and again just before they're assembled. Because drying is an expensive, energy-intensive process, researchers are studying alternative methods of removing moisture that could be implemented more quickly and cheaply. Daniel says the goal in all of these efforts is twofold: to improve the science behind the materials that go into the battery and to improve the battery production process.
The biggest challenge for battery researchers is that there is no single item or step in the process that has enough cost saving potential to meet the over arching goal of making battery-powered vehicles competitive with other vehicles in terms of cost. Despite this challenge, Daniel believes that, working in partnership with industry, the research being done at the battery facility can significantly influence three aspects of battery production: cost, energy density, and production yield. "These things combined will get us to the goal," he says.
Part of the reason for Daniel's optimism is that, currently, batteries are about four times bigger than they need to be. This supersizing helps to ensure that as a battery's ability to store energy lessens over the predicted 15-year life of the vehicle, it will always be able to provide the necessary power. Daniel believes ORNL scientists working with industry will be able to produce a smaller, more cost-efficient battery with greater energy density that will allow vehicles to be driven farther between charges.
Daniel is also confident that production yield—a measure of the quality of the final product—can be significantly improved. He notes that manufacturers know how to judge the quality of the raw material used to produce the battery parts, but once a battery component is assembled, they don't have effective ways to test it until the final product is produced. "If there is a problem with an early step in the production process," Daniel says, "the manufacturer doesn't know about it until the finished battery fails to work."
To address this potentially costly problem, David Wood, a scientist in Daniel's research group, is heading the development of in-line quality-control procedures to detect flaws as early as possible, quantify them, and even repair them—improving both the quality of the final product and the manufacturer's bottom line.
The ultimate goal in the short term, Daniel expects that research and development collaborations at the battery center will help manufacturers reach DOE's battery cost target of $250 per kilowatt-hour. That's about a half to a third of the cost of producing batteries today. The DOE cost target reflects both the level at which the cost of electric vehicles becomes competitive with other modes of transportation and the price point where US battery manufacturers can compete in a global marketplace dominated by Korea, Japan and China.
In the longer term, Daniel expects that the research partnerships being developed at the battery facility will contribute to developing a viable alternative to internal combustion engines for light-duty vehicles. "Right now," he says, "electric vehicles are not drop-in replacements for gasoline-powered cars. The problem is that our whole society runs on fossil fuel, and the volatility of the price of oil is crippling our economy. If we can provide the science and manufacturing technology needed to create a battery that allows us to drive 400 miles on a single charge, then electric vehicles will become a viable option.""That is the ultimate goal." —Jim Pearce
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But just because the climbs aren't as big or as long as the major mountain stages, these races through the Massif Central can be extremely difficult. The challenge here is that the peloton does not split up like it does on major mountain stages. In these stages, the majority of the field largely stays intact all the way to the finish; meaning riders who struggle to climb have to stay with the fastest climbers in the world a lot longer than they will when the big mountains arrive.
The other reason these stages are so hard is that there's no break for your legs. When you're racing through the Massif Central, it seems like you're constantly going up or down; there are virtually no flat roads in the region. The descents are not long enough to provide a lot of recovery and the pace up the climbs can be quite high because riders can see the summits or know they're only a few minutes away. In the big mountains, after the initial flurry of speed heading into the climb, the pace settles down (unless you're fighting in the contenders' group) because the climb is going to last 30 minutes or more.
Skills & Technique
In races with big rolling hills or a series of climbs that only last 5-10 minutes, it's important to conserve as much energy as possible in the early climbs. Amateur racers frequently struggle with this balance between riding strong enough in the early going to stay with the pack, while still conserving power for later climbs.
One way to delay the onset of fatigue is to think about how you're generating your power for climbing. Standing up in a big gear and stomping your way to the summit of a short climb feels pretty good when you're fresh at the beginning of a ride, but you're recruiting a lot of muscle fibers and a lot of them are fast-twitch fibers that fatigue quickly. You want to save these for big accelerations when you really need them and should instead rely as much as possible as the endurance-oriented slow-twitch fibers.


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The Conbraco Series 40-200 Reduced Pressure Principle Backflow Preventer is designed to give maximum protection against backflow caused by either back-pressure or back-siphonage. The durable, but economical, device is easily maintained in the line without any special tools. It consists of two independently acting spring-loaded check valves with an automatic differential relief valve located between the check valves. The diaphragm and the sensing passage are built into the all bronze body to eliminate possible damage. Three of the testcocks are mounted at the top to assure easy access during repair and maintenance when unit is installed in tight places.
1-1/4 - 2 : Lever Handles Conbraco Spec Page
- Part #: 40-207-T2
- Category: Valve
- Brand: Apollo Valves
- Weight: 3.0000


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Lee Cusenbary
Lee Cusenbary is the General Counsel at Mission Pharmacal Company in San Antonio. He is also the creator of Ethics Follies®, a musical parody that uses comedy to raise ethics issues. The fully-produced Broadway-style musical combines San Antonio's business leaders and professional actors to engage the community. It is featured each year by The Association of Corporate Counsel (ACC) for their ethics conference which benefits The Community Justice Program. Lee is also a frequent writer and speaker on why "good ethics is good for business," and is a recipient of the San Antonio Business Ethics Award. In 2012, ACC renamed their ethics awards the "Lee Cusenbary Ethical Life Award" in recognition of his commitment to ethics in law and business. Learn more about how you can be part of a more ethical culture at EthicsFollies.com.
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It is not as hard to get the phrase "Foreign Corrupt Practices Act" into parody song lyrics as one might imagine. Last year, when federal investigations of the FCPA were at an all-time high, Ethics Follies included the reference in a parody of Sondheim's "Leave You" about an executive assistant who quit because her boss […] [Read More]


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Cook At Home For Healthier Food Options
One great advantage of cooking your own meals instead of buying ready prepared food is that you can control what ingredients are used.
If you are health conscious or trying to control your weight it pays to create menus and cook the food yourself, using fresh ingredients and low fat options.
Typically, processed or ready made meals will contain ingredients that you may not want to include in your diet. Also a wide variety of additives are used in processed foods. These have been known to have detrimental effects on the health of some people.
In order to create more flavour in their meals processed food manufacturers often add far greater amounts of sugar, salt and fat than you would use when preparing the same dish at home.
Preparing your own food at home gives you total control over what you eat, giving your body a better chance of greater health.


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Top Notch Linens & Party RentalsServing: Coconut Creek,Fort Lauderdale, Hollywood,Pl...
954-367-2698 Anniversaries, weddings, corporate events, and birthdays are all occasions that demand exceptional thought and care. Make it easy on yourself without sacrificing quality, and rent our... - Read More
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Robin and John Kennedy enjoy preconcert festivities at the Red Carpet Party.
EDDIE SEAL/CONTRIBUTED PHOTO Mike Carrell and Paulette Kluge share symphony stories at the CCSO Pops in the Park — Red Carpet Party.
Linda Strong, Bill Wilhelmi, and Karen Urban visit during the concert's Red Carpet Party.
EDDIE SEAL/CONTRIBUTED PHOTO Lucy and Dick McCracken enjoy the Red Carpet Party at "Pops in the Park."
EDDIE SEAL/CONTRIBUTED PHOTO State Rep. Todd Hunter and his wife, Alexis, who were honorary event chairs, welcome the crowd to "Pops in the Park."
Bill Cone, Host Committee and CCSO Board of Directors member, greets guests from Presenting Sponsor Wells Fargo.


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June 11, 2009
NORTHRIDGE, Calif. - The Cal State Northridge track and field teams competed in several events Thursday at the NCAA Outdoor Track and Field Championships in Fayetteville, Ark. Junior Sherrina Lofton stands in 21st place in the heptathlon after the first four events in the competition while De'Shawn Waters finished 22nd in the 200m. Also for the Matadors, Reindell Cole fouled on all three of his attempts in the men's long jump.
Lofton scored 3,194 points in the first day of the event, which consisted of the 100-meter hurdles, high jump, shot put and 200m. She scored 964 points and finished fifth overall in the 200m, finishing in 24.17 seconds.
Lofton tied for 17th in the high jump with a mark of 1.63 meters (5-04.25 ft) and had a toss of 11.18m (36-08.25) in the shot put. She finished the 100-meter hurdles in 14.92 seconds. Friday brings the long jump, javelin and 800m, starting at 1:45 (CST) at McDonnell Field.
Waters sprinted to a finish of 21.73 seconds in the 200m, good for 22nd in the competition. Although his season comes to an end with the performance, Waters had quite a debut season with the Matadors.
Waters, a junior from Hercules, Calif., won the Big West Conference Men's Track Athlete of the Year in his first season at Northridge. He easily won the 100 meters in a time of 10.53 and then won the 200 meters by the slimmest of margins. Waters ran 21.449 to edge UC Santa Barbara's Jason Newland (21.450). Waters also ran the second leg of the Matadors' 4x100 relay team that also captured a Big West title in a time of 40.55.
At the NCAA West Regionals in Eugene, Ore., he ran a life-time best 10.42 in the 100m for a third-place finish and took fourth with a 21.32 romp in the 200m.
Cole, the 2008 NCAA Indoor Men's Long Jump National Champion, fouled on all three of his attempts in the long jump finals Thursday. It was a bitter finish for the sophomore, coming one day after he broke his own school record with a leap of 8.20m (26-11.25) in the event's preliminaries.
In his second year at CSUN, Cole finished second in the MPSF Indoor Championships in the long jump. He earned back-to-back Big West Field Athlete of the Week awards and was part of the conference-winning 4x100m relay team. Additionally, he finished second in the 100m at the Big West Outdoor Championships and helped the Matador Men's and Women's Teams sweep the league titles.


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The Tampa Bay Rays will be hosting $2 Kids Night at Tropicana Field on Wednesday, August 14 when they take on the Seattle Mariners at 7:10 p.m.! With the purchase of one full-priced adult ticket, fans can purchase up to three kids' tickets (ages 2-14) in select selected seating categories for only $2 each while supplies last. Bring your family out to the ballpark and take advantage of this special offer!
For questions please call 888-FAN-RAYS or if you have already purchased a ticket to this game and would like to upgrade your ticket, please call 727-825-3209.
|Seating Category
|Lower Reserved
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Video and Recipe: The Colbert Bump, Stephen Colbert's Signature Cocktail
After sipping a daiquiri and some rye whiskey, Colbert, true to megalomaniacal form, had Wondrich create a signature cocktail for him. Called The Colbert Bump,* it's based on cherry bounce, a cordial that both Wondrich and Eric Felten of the Wall Street Journal say George Washington used to drink. More


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NL11197 In Stock Absolutely No Delay on Personalization!
A stylish Personalized Tree of Life Tag Pendant is every bit as fashionable as it is symbolic. This 1 inch in diameter stainless steel pendant is engraved on the front with a fully blooming tree, and contains the Latin phrase "Familiae Praestat Nihil." This Latin phrase literally means "Before family nothing," which is a powerful symbol that one's family is the most important thing in his or her life. Some people also look to this tree of life in religious texts as an important part of the Garden of Eden, which plays an important role throughout religious history. Engrave this piece on the back with a family name, motto, or important date to make this piece extra special. Your choice of either an 18, 20, or 24 inch chain allows you to choose the perfect fit for this one of a kind item!
Eve's Addiction.com wants you to be a happy customer. We want you to be completely satisfied with the sterling silver jewelry that you receive from us, as we only sell high quality silver and cubic zirconia cz jewelry. We do understand that you may not like your purchase for some reason.
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text: A late-blooming Monarch Butterfly is getting the royal treatment from Southwest Airlines. The stranded butterfly emerged from her cocoon too late to join the swarm for the fall migration to Mexico. In order help her complete the journey, the airline will be flying the Monarch from Albany, New York To San Antonio, Texas. It is… Read more »


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Top Definition
Toilet Tissue/Toilet Paper... plain and simple.
I'm going to be in here for a while, we're outta godamn shit tickets
додав Dingle Boy 14 Серпень 2003
11 more definitions
Toilet Paper. Usually the cheap crap that they give you at work.
I had an awful case of Green Apple Quickstep but ran outta Shit Tickets.
додав its426 22 Жовтень 2003
euphemism for toilet paper
Hey man, you're outta shit tickets. How's about runnin' to the store real quick? I can't get up.
додав osbo 4 Листопад 2002
one uses to wipe with after going to the bathroom
Did you get the shit tickets because i got to go to the show
додав Paula Esquivel 21 Листопад 2007
a piece of toilet paper
"I need to wipe my ass, but I'm all out of shit tickets!"
додав Luke Swiderski 7 Жовтень 2003
Toilet paper, usually single ply but sometimes multi-ply.
I have to go to the store and buy some shit tickets
додав Simon Callahan 24 Вересень 2010
square of soft paper used to remove feces from one's anus.
The men's restroom did not have enough shit tickets to clean my ass!.
додав dronp 30 Жовтень 2010


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This beautiful sterling silver loop hangs delicately from your choice of a 16, 18, or 20 inch chain. Like a snake, this necklace is dark, daring, and mysterious, with a splash of sparkle. This necklace makes the perfect gift to yourself or for that special someone. Add to your favorite little black dress for the ultimate serpentine girl look!
Eve's Addiction.com wants you to be a happy customer. We want you to be completely satisfied with the sterling silver jewelry that you receive from us, as we only sell high quality silver and cubic zirconia cz jewelry. We do understand that you may not like your purchase for some reason.
You may return or exchange your jewelry within 60 days of purchase if you are not satisfied with it. The jewelry must be returned in its original condition for a refund or exchange. Engraved, personalized, photo, monogram, name and initial, chocolate and clearance items are not returnable or exchangeable.


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Practical info
May 8 – 10, 2012.
Conference venueThe Hub CityView
30 South 17th Street United Plaza Philadelphia, PA 19103 USA
Phone: +1-215-561-8090
Where to stay? Hotels in Philadelphia
We recommend the following hotels, all within walking distance from the conference venue:
- There are many hotels near the conference venue. Some hotels with rooms still available are The Windsor Suites, The Radisson, The Westin or use Hotels.com. If you are having problems securing a room, please call us!
Please contact the hotels directly to make bookings. Let us know if any are fully booked and then we'll update this page.
Organizer: J. Boye
The J. Boye Conferences are organised by J. Boye, an independent networking and knowledge sharing firm, renowned for running groups for online professionals with 400+ member organisations. All activities happen in a vendor-neutral, professional and stimulating environment.


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Wind: 0 mph
Wasn't there another vote that happened at Town Meeting for a town hall? Wasn't there a vote for new select board members, too? What about those votes? Why not support those votes? Does our town really care about what the people want? Seriously? Our town does many things so wonderfully, for which I'm eternally grateful. Our report card, however, is not a 4.0 grade point average.
I'm looking forward to the following classes this year.
101: How to be a friend of Business.
267: Business owners: They are not the spawn of Satan.
103: Voters: Yes, their votes do mean something.
233: Voters: The people we work for and represent.
276: Voters: Votes trump surveys.
324: Voters: If votes don't match your survey, the survey is wrong. How to do a proper survey.
106: Money: It's never free, someone has to pay for it.
257: Budgeting: Yes, we all have to understand how to make ends meet.
1776: Property Rights: We are not vassals to the government (replaces former class 1692: Vassals: We are all subject to the king, know thy place).
376: Inside deals: Just say no to nepotism. America is not your kingdom.
I hear these classes are picking up in popularity, so I'm registering early.
Neil Johnson


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Campus exhibition to feature works by MSU artist-in-residence
A Mississippi State exhibition opening Feb. 21 will showcase works by William "Bill" Dunlap, the university's first and newly named artist-in-residence.
To be featured at the Cullis Wade Depot Gallery through April 5, "Look At It -- Think About It" will feature 16 paintings and constructions completed between 1971-95 by the Mississippi native and nationally recognized artist.
The exhibition is free and open to all, as is a 5:30 p.m. gallery reception on the 21st. At the reception, Dunlap will be discussing his creative processes and signing copies of "Dunlap," a complete catalog of his works.
In addition, the artist will be providing periodic guided discussions of the exhibition. The first begins at 11 a.m. Feb. 26.
Dunlap said he wants his artwork to have a life after his storytelling, so viewers may make their own personally meaningful interpretations of his art.
"What I want to do is engage people on an aesthetic and personal level and give them something to contemplate," he explained.
For more about the Dunlap exhibition, contact gallery coordinator Lori Neuenfeldt at 662-325-2973.
Margaret Kovar | University Relations


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Sweet, tangy, tart — whatever the type of apple, these decadent treats will have you swooning for autumn's star fruit.
A link to %this page% was e-mailed
Embed Link
Rachel's Dutch apple cake recipe makes a yummy, virtually foolproof treat.
At an apple farm, cooks show the steps for making a classic apple pie.
Get Cooking Channel on your TV.


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May 20, 2009 -- People with Down syndrome hold the key to a new generation of cancer drugs, researchers say.
Solid tumors are very rare in people with Down syndrome. Why? The answer almost certainly lies among the 231 extra genes they inherit with their extra copy of chromosome 21.
Narrowing the search for the anti-cancer gene is another observation: People with Down syndrome rarely get diseases linked to the overgrowth of blood vessels.
Might the anti-cancer effect of Down syndrome be linked to something that blocks the growth of new blood vessels? To find out, Sandra Ryeom, PhD, and colleagues at Children's Hospital Boston designed a clever series of experiments.
One of the genes on chromosome 21 encodes a protein that blocks a factor needed for blood vessel growth. They found that this protein, DSCR1, is overproduced in people with Down syndrome. It's also overproduced in about the same amounts in a mouse model of Down syndrome.
Might the extra protein really affect blood vessel growth? When Ryeom and colleagues looked at tumors grown from Down syndrome stem cells, they saw that these cancer cells had fewer blood vessels than cancers grown from normal stem cells.
Further experiments confirmed that DSCR1 inhibited angiogenesis, or blood vessel growth.
Given that people with Down syndrome have 231 extra genes, it's improbable that DSCR1 is the only one with anti-cancer effects. And Ryeom and colleagues found evidence that another chromosome 21 gene, Dyrk1A, contributes to the anti-angiogenesis effect.
"I think there may be four or five genes on chromosome 21 that are necessary for angiogenesis suppression," Ryeom says in a news release.
"It is, perhaps, inspiring that the Down syndrome population provides us with new insight into mechanisms that regulate cancer growth and, by so doing, identifies potential targets for tumor prevention and therapy," Ryeom and colleagues conclude.
The findings appear in the early online edition of the journal Nature.


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terri55 commented on 12/28/14
they have some good deals.


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towerelf: Quiz Results
Could You Be a Smokejumper? taken about 5 years ago
Future Smokejumper
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almost 5 years ago
800 comments
Battling the Beast
Wearing class A uniforms, they sit sometimes for days, laughing, eating, joking...waiting for one sound, a tone that transforms them.
They abandon their armchairs for rubber boots, and their armor heavy and hot. Instead of trading jokes they relay directions, and orders, and shout reports of the status of the ENEMY--- "FLAMES ARE VISIBLE"
Fear and excitement grip the hearts of the freshest rookie to the oldest veteran as they jump into their big red fire trucks, perfect from washing, waxing and checking over and over. They pray that they have made no mistakes. The driver navigates the BRFT(big red fire truck) through the tight city streets that he knows as well as his family, dodging those that get into the way, hoping those he can't avoid will see him first.
They spot the ENEMY from blocks away - the column of smoke rises far above the trees, licking the sky.
They arrive at the scene, and again the battle cry is heard---- "FLAMES ARE VISIBLE"
Smoke fills the air and their lungs as they approach, hoses snaking, crisscrossing, coming to life as they surge the water from the fire hydrants to the fire trucks, that then sends the water to the hoses, turning them into weapons to use against the enemy.
The firefighters force open the front door, and a flash of liquid orange flame rolls out into the air trying to escape its defeat. With swords of water and suits of armor the firefighters advance into the structure, that is fully involved with flame, heat, and smoke.
They battle the BEAST nine or ten against one seemingly great odds.
But the nine or ten will win, emerging from the battlefield victorious as they always do, and eventually, they'll retire to their armchairs, thanking GOD that this time nobody was hit by the enemy "................FIRE................"
-author unknown -
On duty today, a very busy day so far. So bring it on Sanford lol
On duty today, Stay safe everyone!
Well back to work on Thursday after my kelly day. T31 here I come
on e-21` today staying safe
about 5 years ago
13042 comments
thanks for the add
thank you
about 5 years ago
19096 comments
Thank you stay safe.


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Tuesday, September 3, 2013
Windsor Hill Arts Infused Elementary students fifth graders Jayvion Snow and Kailin Sullivan perform Do You Believe In Me For the Dorchester District Two Board of Trustees Monday. Superintendent Joe Pye invited them to the board meeting after seeing their performance on the first day of school.
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