text:
I'm getting around to building my semiauto Sten (SAS3 kit), and I came across a couple of questions.
1) I'd like to build with rivets instead of welding the trunnions to the barrel; is this advisable, feasible, or recommended? Is it a no-no? If this is okay (I assume so, since the original was riveted), then what rivets are used? Mild steel? Stainless?
2) Assuming that it's okay to rivet the trunnions, where can one find small quantities of rivets? I've found places that are willing to sell thousands of rivets, but not a small quantity like I need.
3) The new SAS3 kit doesn't have the rods threaded into the slug. Are these supposed to be welded, or to just float?
Any help is appreciated.


text:
American Academy of Dermatology
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Melanoma. EBSCO DynaMed website. Available at:
http://dynamed.ebscohost.com/about/about-us. Updated April 3, 2013. Accessed April 9, 2013.
Melanoma. National Cancer Institute website. Available at: http://cancer.gov/cancertopics/types/melanoma. Accessed April 9, 2013.
Melanoma skin cancer. American Cancer Society website. Available at:
Updated January 17, 2013. Accessed April 9, 2013.
Physician quality reporting system quality measures. EBSCO DynaMed website. Available at:
http://dynamed.ebscohost.com. Updated February 5, 2013.
Accessed April 9, 2013.
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As of March 1st there will be 3-52 Sport Coupes available for spring. Get your orders in and don't miss out on a spring delivery. Please call the Basa's marine sales staff for current show time sales event promotions and pricing?
The Company offers the details of this vessel in good faith but cannot guarantee or warrant the accuracy of this information nor warrant the condition of the vessel. A buyer should instruct his agents, or his surveyors, to investigate such details as the buyer desires validated. This vessel is offered subject to prior sale, price change, or withdrawal without notice.
Owners can personalize the Regal 52 to suit their individual tastes. This is as close to a custom-built yacht as you can get in 52 feet. The highly versatile 52 SC will be offered with two cockpit layouts: one with extended seating and the other featuring a garage that can store a dinghy. Four different cabin interiors are available, including two- and three-stateroom versions. The extensive range of options for interior fabrics, countertop materials, cabinetry and flooring are truly custom-build level in their scope and quality. Models will be equipped with a choice of Volvo IPS 600 or Volvo D-9 575-hp V-drive diesel engines.
Additional twin engines by Volvo available. Twin diesel engines available.
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Sherri Jean Silvas, 47, of Waterbury, Vermont, passed away unexpectedly at home last week. Sherri was born on January 11, 1966, in Texas. She received a bachelor of fine arts from the University of the Arts in Philadelphia, PA, in 1997 and a paralegal certification from Naugatuck Valley Community College in Connecticut in 2007. She had been employed as an advocate with Disability Rights Vermont since March of 2009.
Sherri had an innate passion for helping others, which came through in everything she did. She enjoyed cooking, the arts and being active outdoors. She was an avid New England Patriots fan. Her smile and personality brightened every room into which she walked. There was much joy and love shared between Sherri and several special children and friends in her life.
A gathering to celebrate Sherri's life will be held on Thursday, July 18, from 2 to 4 p.m. at the new accessible Pavilion Shelter in Hubbard Park in Montpelier. All are welcome to attend. The Perkins-Parker Funeral Home and Cremation Service in Waterbury is assisting with arrangements.


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Steps to Finding a Job
Steps to Finding a Job
Step 1 | Check Job Postings
Jobs are posted throughout the academic year as they become available. Current open positions are posted on the Online Job Board.
Step 2 | Submit an Application
The job posting will list the hiring supervisor's contact information as well as how to apply for the position. It is recommended that you have a current resume when applying for a position.
Step 3 | Complete New Hire Paperwork Steps


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PDT Staff Report
According to the National Weather Service, Scioto, Pike, Adams, Jackson and Lawrence Counties in Ohio are under a Severe Thunderstorm Watch. Greenup County in Kentucky is also under a Severe Thunderstorm Watch. For each county, the watch expires at 6 a.m.
A severe thunderstorm as defined by the National Weather Service is a storm with hail equal to or larger than 3/4 of an inch in diameter or convective wind gusts equal to or greater than 58 miles per hour. Even if a storm is not severe, it still remains a potential killer. Lightning, flash flooding, wind blown hail (even small hail), and general thunderstorm wind gusts pose a threat to life and/or property. Severe thunderstorms also have the potential of producing a tornado with little or no advanced tornado warning.
Power outages often accompany severe thunderstorms.
The Public Utilities Commission of Ohio (PUCO) is reminds Ohioans exercise caution during power outages. Downed electric lines, equipment and vegetation can potentially be hazardous and should be avoided.
Do not attempt to touch or move downed electrical lines and equipment. Downed lines pose a serious hazard to anyone who comes in contact with them and can be deadly. Immediately report downed lines to emergency responders and your local utility. Do not attempt to move fallen debris in the vicinity of a downed power line and keep at a safe distance at all times.
Additional safety tips during a power outage include:
•If using a generator, be sure it is properly ventilated to avoid carbon monoxide poisoning.
•Do not attempt to use a gas stove or oven to heat your home.
•Unplug electrical devices in case of a power surge. Leave one lamp on so you know when power has been restored.
•If possible, use only battery-powered light sources for emergency lighting instead of candles. Matches, lighters and candles are fire hazards.
•Check on your neighbors, friends and family to ensure they are okay.
•Call an electrician if you have standing water near electrical wiring or appliances. Do not enter the flooded area.
For additional safety tips during electrical power outages, visit the Ohio Emergency Management Association's website at www.ema.ohio.gov.
To review the PUCO's guide to being prepared for power outages, please visit the PUCO website at www.PUCO.ohio.gov.


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Nov. 23, 1994 – Left wing Steve Maltais records the Wolves first-ever hat trick in a 7-4 victory against the Cleveland Lumberjacks.
Dec. 1, 2001 – The Wolves retire former goaltender Wendell Young's jersey, the first time in the team's eight-year history that a number is retired.
Dec. 2, 1998 – The Wolves record their 100th all-time victory on home ice when they defeat the Orlando Solar Bears, 7-4.


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Financial Economics Institute
The Financial Economics Institute provides several powerful databases to the students and faculty of Claremont McKenna College. These databases provide important tools for research and classroom activities, as well as for senior theses. A detailed description of the data sources can be found below.
Bloomberg Professional
The Bloomberg Professional service integrates data, news, analytics, multimedia reports, research, and trading capabilities into a single platform. The system's technology provides a reliable, secure, state-of-the-art network to assure fast, free-flowing access to information via a Bloomberg Terminal.
The Bloomberg Terminal offers quick access to important financial information and news, both of which are updated 24 hours a day. The service includes access to data from international equity markets, money markets, currency markets, municipal and corporate bond markets, and commodity markets. The Terminal is used to navigate the Bloomberg services more efficiently by having instant access to securities data, real-time pricing, historical pricing, news and research, as well as recorded interviews, analytics, and a 'Portfolio System' which allows the user to analyze and price customized portfolios.
For detailed information on how to use a Bloomberg Terminal, please download the FEI Bloomberg Tutorial (PDF).
The Wharton Research Data System (WRDS) maintains several databases in easy-to-use and up-to-date formats. This web-based data management system allows faculty and students to easily retrieve information from a wide variety of financial, economic, and marketing data sources. Through WRDS, CMC subscribes to COMPUSTAT North American, CRSP, Thomson Financial, Board Analyst, SDC Platinum, IRRC, and I/B/E/S, in addition to the handful of data sets that automatically come with WRDS. Detailed descriptions of these services can be found below.
Claremont Consortium faculty, administrative staff, and students are welcome to use the following tutorial to help get you started in creating a WRDS account.
Board Analyst
Board Analyst is a comprehensive source of objective corporate governance and compensation information, providing powerful online research and analytic tools to easily access and compile critical company information. For each proxy year beginning in 2001, information includes: corporate board structure and independence, director positions and committee assignments, executive compensation, director compensation, audit fees, corporate ownership, and takeover defenses.
COMPUSTAT North America
A product of Standard & Poor's, COMPUSTAT North America is a database of U.S. and Canadian fundamental and market information on more than 24,000 active and inactive publicly held companies. It is a near census of publicly traded firms, providing thousands of annual reports, income statements, statements of cash flows, and supplemental data items.
COMPUSTAT North America offers files that are available in both annual and quarterly formats. The industrial annual formats offer both historical and restated data. The industrial quarterly formats offer restated data as reported by the various companies. The restated data allow analysts to compare current and prior years' results on a comparable basis and determine financial trends and growth rates. For most companies, annual and quarterly data are available for a maximum of 20 years and 48 quarters. In many cases, data stretch back fifty years or more. COMPUSTAT North America files also contain information on aggregates, industry segments, banks, market prices, dividends, and earnings.
ExecuComp is also available within the COMPUSTAT system. This dataset includes over 80 different compensation items on more than 12,500 executives (top five executive officers per company), and over 35 measures of company financial performance taken from COMPUSTAT. The data are annual and available from 1992 forward.
Founded in 1960, the Center for Research in Security Prices (CRSP) maintains the most comprehensive collection of standard and derived security data available for the NYSE, AMEX and NASDAQ Stock Market. CRSP is a research center at the University of Chicago Graduate School of Business, and maintains historical data spanning from December 1925 to the present. CRSP's trademark of unique issue identifiers tracks a continuous history of securities, providing a seamless time-series examination of a given issue's history. CRSP's unparalleled accuracy and dedication to excellence has made CRSP data a staple of academic and commercial research and data analysis throughout the world.
CRSP also provides links to allow CRSP and COMPUSTAT to be accurately matched at each point in time, irrespective of name changes and M&A activity. Without these links, it is difficult to match the historical accounting and financial markets information.
I/B/E/S International Inc. created their Academic Research Program over 30 years ago to provide both summary and individual analyst forecasts of company earnings, cash flows, and other important financial items, as well as buy-sell-hold recommendations. The Institutional Brokers Estimates System database includes historical estimates for 35,000 companies around the globe. With U.S. coverage back to 1976 and International coverage back to 1987, I/B/E/S data are unique for providing historical insight across a variety of market conditions.
Investor Responsibility Research Center (IRRC)
Founded in 1972, the Investor Responsibility Research Center (IRRC) provides independent research and data covering corporate governance, proxy voting, and corporate responsibility issues. IRRC's Directors Dataset details the structure and practices of boards of directors for around 1,500 of the largest companies publicly traded in the U.S. IRRC's mission is to provide the highest quality research on companies and shareholders worldwide.
Thomson Financial Insiders Filing Data
Through the Insiders datasets, one can find up-to-date data on a wide array of insider trades. Data are available from 1986 forward.
Thomson Research
A service distinct from WRDS, this resource provides access to comprehensive company information, including SEC filings, Worldscope reports and financials, and Extel Cards that provide as-reported filings, recent company announcements, and detailed business information (including up to 1,400 data items on each Extel Card) from thousands of global companies. Thomson also offers the EDGAR Free Text search function, which allows users to search SEC Filings for a given word or phrase. Thomson One Banker offers quick and easy access to quotes, earnings estimates, financial fundamentals, market moving news, transaction data, corporate filings, ownership profiles, peer comparisons, and research from industry-leading sources.
For access information for Thomson Research, please contact the Financial Economics Institute at email@example.com
Other Databases Available to Students of the Claremont Colleges
Note: You must be on the campus of one of the Claremont Colleges (including CGU) to access these resources.
ABI/Inform contains abstracts and full articles from thousands of journals aimed at helping people track "business conditions, trends, management techniques, corporate strategies and industry specific topics worldwide." This resource provides access to a number of publications, including Barron's, Business Week, and The Wall Street Journal. This resource is available via ProQuest.
Chicago Board Options Exchange
The Chicago Board Options Exchange, CBOE®, offers current and historical market data, aimed at helping options traders make more informed decisions. Data is available on daily market statistics, intra-day volume, annual market statistics, historical stock volatilities, and more.
D&B's Million Dollar Database
D&B's Million Dollar Database provides company information such as type of ownership, number of employees in America and abroad, and biographies of principal executives. The Claremont College's subscription provides information on more than 1,600,000 public and private businesses in the United States and Canada.Financial Data Finder
The Financial Data Finder, offered by the Fisher College of Business at Ohio State University, is a collection of references to web sites devoted to various areas of finance. It is targeted to the needs of researchers and students.
Financial Data: Current & Historical
This website contains a collection current and historical financial data, updated regularly. Sections include: money stock, interest rates, banking data, U.S. Treasury data, national debt, and macroeconomic data.
Federal Reserve Economic Data (FRED®)
FRED®, a database of over 3,000 U.S. economic time series, provides data for download in Microsoft Excel and text formats, along with charts of data series. Categories include banking, CPI, unemployment, exchange rates, GDP, interest rates, and more. The newly introduced ALFREDTM, ArchivaL Federal Reserve Economic Data, can also retrieve vintage versions of data that were available on specific dates in history.
Global Financial Data
Comprehensive economic and financial time-series database covering 200 countries and 6,500 different data series. Includes data on stock markets from 1690, exchange rates from 1590, interest rates from 1700, commodities from 1500, and inflation from 1264. Selected current and historical stock price data is also available. Users can download data into spreadsheet format or use the graphing.
Hoover's Online
Hoover's Online offers an easy-to-use web-interface that provides an overview of over 12 million companies and 600 industries. This database provides information on competitors, subsidiaries and, for select corporations, features such as short videos of speeches from the CEOs. Additional tools allow you to build custom lists of executives, conduct custom news searches, and compare peer companies.
Mergent Online
Mergent Online covers more than 10,000 public companies in the United States and provides access to their SEC filings. Mergent also offers a large selection of information on a number of international companies. This database allows you to search and download information from EDGAR (a database of all SEC filings), create custom reports, and download data in various formats.
Princeton University Pliny Fisk Library of Economics & Finance
The Pliny Fisk Library of Economics & Finance provides a detailed guide to finding and using financial data. This handbook is directed towards those conducting research at Princeton University, therefore some of the resources listed are not available to individuals outside of the Princeton community.
Valueline Investment Survey Online:
The Value Line Investment Survey is a comprehensive source of information and advice on approximately 1,700 stocks, more than 90 industries, the stock market, and the economy. The Ratings & Reports section contains one-page reports on approximately 1,700 companies and more than 90 industries. The Timeliness Ranking System forecasts the next six to twelve months of relative price performance for the featured stocks.
For additional database resources, please visit the Library's web site at: http://libraries.claremont.edu/resources/databases/bysubject.asp?SubjId=17.
Financial Economics Institute
Claremont McKenna College
Bauer Center
500 E. Ninth Street
Claremont, CA 91711-6400


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Wednesday, February 24, 2010
Bread & Chocolate is truly a match made in heaven. Bread & Chocolate warms and comforts, soothes and de-stresses. Bread & Chocolate is the perfect energizing breakfast, a most delightful snack for any age, a sumptuous, elegant dessert.
Walk down any Parisian street and see tiny hands grasped around chunks of baguette with a bar of chocolate, dark or milk, sticking out each end or chic young things nibbling on pains au chocolat fresh from the bakery. Wander through any high school bake sale and see loaves of banana or pumpkin or zucchini or orange studded or swirled with chocolate chips, that best of friend to any flavor, the perfect match for lemon or cranberry or any dried fruit or nut in a sweet bread. Ask your kids what they want you to bake for breakfast or choose the perfect snack to pair with a tall, cool glass of milk or a hot mug of coffee or tea and you'll find yourself stirring up batter for chocolate chip muffins or scones.
Bread & Chocolate: A little shot of carbs followed straight with a bang of chocolate. Whether baguette or flaky puff pastry, warm-from-the-oven scones or dense, moist pudding or just-sweet muffins is your poison, whether you like your chocolate dark or light, crunchy, crispy or gooey, whether you like your bread dotted with chocolate or drenched in the stuff, bread & chocolate turns everyone on (and in more ways than one!). Homey and filling or seductive and elegant, eaten quietly slice by slice or slathered with whipped cream and scooped up greedily, who can turn down that most delightful, that most sensual of combinations, Bread & Chocolate?
When Meeta of What's For Lunch Honey? asked me to host Monthly Mingle, Bread & Chocolate popped straight into my head. Bread & Chocolate in any form is true comfort food, the stuff of quiet afternoons curled up in your favorite armchair with a good book or doling out treats to rambunctious kids or the first thing we look for to ease both our jet lag and our childlike excitement while on vacation off in some exotic, far-off land. And everyone seems to agree as you can see by this amazing selection of goodies baked especially for Monthly Mingle by all these incredible food bloggers.
So just pull up a chair, grab and knife and a fork and dig in!
Elle of Feeding My Enthusiasms
Amazing Overnight Waffles with Chocolate Chips & Dried Cherries
Astrid of Paulchen's Foodblog
Chocolate Brioches
Aparna of My Diverse Kitchen
Brioche with Chocolate Ganache
Quinn of Quinn's Baking Diary
Bread Cake
Deeba of Passionate About Baking
Nutella, Walnut & Orange Rolls
Heather of Eggs, Cream and Honey
Chocolate Insanity Bread Pudding and Chocolate Beer Sauce
Ino of Kitchen 22
Chocolate Bread and Butter Pudding
Parita of Parita's World
Eggless Chocolate Raisin Coffee Bread
Finla aka Happy Cook of My Kitchen Treasures
Chocolate Buns
Adele of Will Work for Biltong
Chocolate Pizza Pockets
Swathi of Zesty South Indian Kitchen
Raspberry Coconut White Chocolate Bread
Simona of A Tutta Cucina
Panini al Cioccolato e Noci (Chocolate and Walnut Panini)
Sunita of Sunita's World
Chocolate and Orange Quick Bread
Joanne of Eats Well With Others
HBin5 Cranberry Tangerine Chocolate Bread
Sarah of Ratatouille
Chocolate Chip Chudleighs
Priya of Priya's Easy N Tasty Recipes
Nutella Swirl Bread
Barbara of Barbara Bakes
Triple Chocolate Cherry Quick Bread
Nina of Confessions of a Bake-a-holic!
Austrian Bread Pudding with Chocolate
DK of Chef in You
Chocolate Chip and Hazelnut Bread
Jayasri of Samayalarai – Cooking is Divine
Chocolate Babka
Rachel of Tangerine's Kitchen
Orange Chocolate Chip Loaf
Soma of eCurry
Eggless Chocolate Zucchini Nut Bread
Lakshmi of Palate Desires
Chocolate Drizzled Pretzel
Sweatha of Taste Curry Leaf
Gluten-Free & Fat-Free Chocolate Banana Bread
Nic of Cherrapeno
Mini Panettone with Butterscotch, Chocolate, Macadamia Nuts and Cranberries
Deborah of Italian Food Forever
Chocolate Coffee Bread Pudding
Meeta of What's For Lunch Honey?
Rich Chocolate Breads with Pistachios, Pink Praline and Au Naturel
Ozoz of Kitchen Butterfly
Columbian Banana Bread – Pan de Banano
Cool Lassi(e) of Pan Gravy Kadai Curry
Heart-y Sweet Bread N Chocolate Pudding
Asha of Fork-Spoon-Knife
Chocolate, Cranberry and Candied Citrus Spiced Bread
Hilda of Saffron & Blueberry
Gluten-Free Pear and Chocolate Muffins
Cinzia of Cindystar
Bread Chocolate Cake
Jamie of Life's a Feast
Chocolate Orange Buttermilk Muffins
Chocolate Custard Bread Pudding
And a huge apology to Apu of Annarasa - Essence of Food who baked these fabulous Spicy Carrot, Spring Onion, and Black Sesame Rolls for my Bread Baking Day #26 but they were left floating around the blogosphere.....
Thank you so much, each and every one of you, for participating in my Monthly Mingle. It was scrumptious!
And please do not forget about the H2Ope for Haiti Raffle! You have until Midnight Sunday 28 February to buy your tickets here for any or all of these fabulous prizes you can find here on Jeanne of Cook Sister!'s blog. I have donated this box of Fabulous French Baking Treasures.
42 comments:
- Sarah M. said...
What a wonderful and varied collection of bread and chocolate.
Pain du chocolat is one of my favorite foods but its interesting to see what other ideas there are.
- February 24, 2010 at 2:40 AM
- My Carolina Kitchen said...
What a lovely round-up of bread and chocolate Jamie. They are all beautiful, but the chocolate pretzel is calling my name.
- February 24, 2010 at 3:00 AM
- sunita said...
What a delicious round up this is, one is spoilt for choice. Thanks Jamie
- February 24, 2010 at 3:07 AM
- Jamie said...
@My Caroline Kitchen : Sam, right? I am so making those pretzels!
- February 24, 2010 at 3:13 AM
- Rosa's Yummy Yums said...
What a fantastic roundup! I am now drooling all over my keyboard...
- February 24, 2010 at 3:23 AM
- diva said...
Fab collection and truly a match made in heaven. Bread and chocolate is just mindblowingly good. :) I'm loving Aparna's chocolate brioche with the sugar topping. So good!
- February 24, 2010 at 3:56 AM
- MeetaK said...
oh my goddness my waistline expand twofolds with this roundup. first jamie - thanks for jumping in so quickly and being the best hostess. second thanks to everyone for being so creative. impressive looking roundup!
- February 24, 2010 at 4:20 AM
- Happy Cook said...
Beautiful and delcious roundup. I can sit here and drool on each of the pics.Thankyou for hosting and doing all the work for the event.
- February 24, 2010 at 4:21 AM
- ABowlOfMush said...
Wow everything looks amazing!
Mmm yum I love chocolate bread, in any form! :)
- February 24, 2010 at 4:21 AM
- Deeba PAB said...
OK now I'm sulking because you ate my bread sistah!! Where are my rolls??
- February 24, 2010 at 5:17 AM
- Barbara Bakes said...
Great roundup! So many fabulous recipes to try! I baked up a chocolate cherry quick bread for your mingle, but it wasn't chocolatey enough and I didn't want to post it :-(
- February 24, 2010 at 6:09 AM
- Cool Lassi(e) said...
What an awesome roundup! Now I have to try some of these as they are look drool-worthy!
- February 24, 2010 at 6:41 AM
- Sarah, Maison Cupcake said...
Fabulous round up, you did great job of hosting as I know you stepped in at last minute.
So disappointed I was not able to submit anything in time but I hope to be mingling next month.
- February 24, 2010 at 6:55 AM
- Soma said...
This is one happy round up! Thank you Jamie for doing it so beautifully.
- February 24, 2010 at 7:49 AM
- Asha @ FSK said...
Awesome! what a round up! So many breads I need to make now :DD
- February 24, 2010 at 8:21 AM
- Elra said...
What a beautiful round ups Jaime. They all look very delicious.
- February 24, 2010 at 8:27 AM
- Barbara Bakes said...
Thanks for encouraging me to post my Triple Chocolate Cherry Bread! I think you're my new favorite person!
- February 24, 2010 at 8:51 AM
- Chow and Chatter said...
wow what a amazing round up I want to taste them all !
hope your well Jamie
Love Rebecca
- February 24, 2010 at 9:56 AM
- Mary said...
Jamie, the round-up is wonderful and has sparked lots of ideas. I'll try to visit all of the participants. Have a grand day.
- February 24, 2010 at 10:08 AM
- Rambling Tart said...
Oh Jamie, what a splendid idea. :-) My family is Danish and I grew up eating thinly sliced chocolate on thickly buttered rye bread. So wonderful. :-)
- February 24, 2010 at 11:26 AM
- Junglefrog said...
What an amazing round up of gorgeous recipes!! For sure a couple of them worth trying out!
- February 24, 2010 at 1:14 PM
- Adele said...
Jamie, obviously I wasn't the only one thinking your theme was fabulous. Great round-up, thanks very much.
- February 24, 2010 at 2:20 PM
- Mowie @ Mowielicious said...
Oh my! This is some party you're having here. I'm so sorry I couldn't take part this month, my plate is so full (no pun intended!), hopefully I'll be able to join you gals for the next one. Great round-up Jamie. Miss you xxx
- February 24, 2010 at 2:52 PM
- creampuff said...
Well you'll get no argument from me on that point! I'm a huge bread and chocolate fan especially when the "chocolate" is Nutella! Love it!
- February 24, 2010 at 5:02 PM
- 5 Star Foodie said...
A fantastic round up! Really wonderful creations here!
- February 24, 2010 at 5:49 PM
- Natashya KitchenPuppies said...
Lovely round-up!
Such a remarkable combination.
- February 24, 2010 at 8:38 PM
- Cindystar said...
Wowwwwwwww ... what a choco lovely dance!
Thanks again for hosting such a delicious event, Jamie!
- February 24, 2010 at 10:59 PM
- Ann said...
Nice round-up - so many recipes, so little time. I really wanted to send in an entry as I am a recovering breadaholic and 12-step dropout chocophile. I attempted an orange/chocolate/bread pudding and ended up with mush covered in a crust with a blob of chocolate. Awful. It would have stuck out like a sore thumb in your list of goodies, so I stayed far, far,away!
- February 25, 2010 at 7:42 AM
- Jamie said...
@Ann - thanks for checking in and giving me a chuckle. We all have kitchen disasters and some of us toss them in the trash never uttering a word and others gather up their courage and actually post them. Personal choice, but your avowal here has me laughing! Do join us next month where the theme is champagne (on Meeta's blog).
- February 25, 2010 at 7:46 AM
- Rachel said...
Each is beautiful and a roundup well done.
- February 25, 2010 at 8:05 AM
- Nicisme said...
What a gorgeous line up of wonderful treats! I honestly don't know where to start first - probably should work my way through the list in a sensible order, lol!
Thank you Jamie for doing this!
- February 25, 2010 at 8:51 AM
- Annarasa said...
Beautiful round-up of such delicious treats Jamie!! Delighted to see that the rolls have found a home at last:)
- February 25, 2010 at 10:12 AM
- SipitySup said...
beautiful stuff. (burp...) GREG
- February 25, 2010 at 1:56 PM
- theUngourmet said...
It's bread and chocolate heaven! Everything looks completely delicious! I really like the look of that chocolate pretzel.
- February 25, 2010 at 9:40 PM
- Katy ~ said...
A chocolate and bread extravaganza and certainly a feast for the eyes and the belly! Each recipe is beautiful, elegant, irresistible. Well done and many kudos to all who participated.
Such sweet inspiration!
- February 27, 2010 at 4:32 AM
- Sweets By Vicky said...
Awesome monthly mingle! This is probably the best place to get away with chocolate for breakfast!
- February 27, 2010 at 7:29 AM
- Parita said...
A fantastic roundup!!
- February 28, 2010 at 3:38 AM
- Lorraine @ Not Quite Nigella said...
A gorgeous idea Jamie! I wish I had more time in front of an oven to participate in this. I had every intention to! But it looks like you had a sterling turnout! :D
- February 28, 2010 at 5:19 AM
- Sari said...
What a wonderful mouthwatering round up! But I don't see my chocolate brioche here :(
- March 9, 2010 at 1:12 PM
- Jeanne @ Cooksister! said...
Oh my... what a delectable collection! I think I may have gained some pounds just looking that them :) Great roundup Jamie!
- March 10, 2010 at 8:25 AM
- asiangrrl said...
Oh my goodness. This post is like true food pr0n to me, Jamie. I'm bookmarking it so I can drool over it periodically.
- April 5, 2010 at 4:30 PM
- Mike said...
When I was little my mom would make chocolate chip muffins and whenever I ate them I was in heaven. I'd also share them with my friends and they would be in heaven too.
- September 29, 2012 at 8:02 AM


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Past course pages are available here: http://www.math.purdue.edu/academic/courses/past/.
Important Notes:
- ADA policies: please see our ADA Information page for more details.
- In the event of a missed exam, see your instructor/professor as soon as possible.
- See the online course evaluation page for more information on how we collect course feedback from students.


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6mm, 480.0 fps, Synthetic, Ambi, Black
Package: Included with the UTG Type 96 is a tri rail quick release bi-pod adapter, UTG weaver rail bi-pod, UTG speed loader and a sling, Leapers Golden Image 4x32 Rifle Scope (item # SCP-U432FW).
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What others should know:This is a great sniper rifle. It is a smoothbore so you can only shoot so accurate but for the price point it's great.
Things I liked:The style of gun, price, easy disassembly and how smooth everything worked.
Things I would have changed:Adjustable trigger maybe, the trigger is fine but options are always a plus.
What others should know:You can't go wrong with this gun, its got the power, accuracy and quality to hang up there with the Mauri's at a way lower cost. Also, i recommend using .30 gram bb's
Things I liked:It is sturdy and accurate, plus it came with an extra mag! Overall for the money this is a great bolt action sniper for long time players and entry level. It really gets you into sniping
Things I would have changed:The bi-pod is sturdy but the mount for the bi-pod IS NOT. I put a little towel between the rail mount and the barrel and it sits fine with little wobble and sound
What others should know:the hop up is tricky to adjust because you have to use an little wrench to do it. I would order the metal upgrade for it. I have had this gun for 2 years and my trigger box broke after firing more than 10,000 shots. i ordered a new one from Pyramyd today!
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text:
A stent mounting device and a method of coating a stent using the device are provided.
1. A method of coating a stent, comprising:
mounting a stent on a support assembly;
positioning a shielding member to cover a selected portion of the stent without the shielding member being in contact with the stent, wherein the shielding member is configured to reduce or eliminate coating material applied to the selected portion of the stent; and
applying a coating material to the stent for forming a coating.
2. The method of
3. The method of
4. The method of
5. The method of
6. The method of
7. A method of coating a stent, comprising:
mounting a stent on a support assembly;
spraying via a spray nozzle a coating composition onto the stent; and
positioning a shielding member between the stent and the spray nozzle to shield a selected portion of the stent during the spraying of the coating composition such that the shielding member does not make contact with the stent.
8. The method of
9. The method of
10. The method of
11. A method of coating a stent, comprising:
positioning a stent on a support assembly such that at least a segment of the stent is inserted into a hollow tubular body that is adjustably integrated with the support assembly, the hollow tubular body adapted to reduce an amount of or prevent a coating composition from being applied to an area of the stent covered by the tubular body;
adjusting the position of the hollow tubular body over the stent to an area which a user wants to cover by a means for adjusting the position; and
applying a coating composition to the stent.
12. A method of coating a stent, comprising:
positioning a stent on a support assembly such that at least a segment of the stent is inserted into a hollow tubular body that is adjustably integrated with the support assembly, the hollow tubular body adapted to reduce an amount of or prevent a coating composition from being applied to an area of the stent covered by the tubular body, wherein the hollow tubular body does not make contact with the stent;
adjusting the position of the hollow tubular body over the stent to an area which a user wants to cover; and
applying a coating composition to the stent.
13. The method of
14. A method of coating a stent, comprising:
positioning a stent on a support assembly;
positioning a shield between a nozzle assembly and the stent so that the shield does not make contact with the stent, wherein the position of the shield is adjustable with respect to the support assembly; and
applying a coating composition to the stent.
15. The method of
16. The method of
17. The method of
18. The method of
19. A method of coating a stent, comprising applying a coating composition on a stent, positioned on a support assembly, by a nozzle such that a shield member positioned between the nozzle and an outer surface of the stent reduces an amount of or prevents the coating composition from being applied on an outer surface of the stent underneath the shield member, wherein the shield member does not make contact with the outer surface of the stent underneath the shield member during the application of the coating composition.
20. The method of
21. The method of
22. The method of
This is a divisional application of U.S. Ser. No. 09/896,436, which was filed on Jun. 28, 2001 and issued as U.S. Pat. No. 6,565,659.
1. Field of the Invention
This invention relates to a stent mounting device and a method of coating a stent using the device.
2. Description of the Background
Blood vessel occlusions are commonly treated by mechanically enhancing blood flow in the affected vessels, such as by employing a stent. Stents act as scaffoldings, functioning to physically hold open and, if desired, to expand the wall of the passageway. Typically stents are capable of being compressed, so that they can be inserted through small lumens via catheters, and then expanded to a larger diameter once they are at the desired location. Examples in the patent literature disclosing stents include U.S. Pat. No. 4,733,665 issued to Palmaz, U.S. Pat. No. 4,800,882 issued to Gianturco, and U.S. Pat. No. 4,886,062 issued to Wiktor.
Stents are used not only for mechanical intervention but also as vehicles for providing biological therapy. Biological therapy can be achieved by medicating the stents. Medicated stents provide for the local administration of a therapeutic substance at the diseased site. Local delivery of a therapeutic substance is a preferred method of treatment because the substance is concentrated at a specific site and thus smaller total levels of medication can be administered in comparison to systemic dosages that often produce adverse or even toxic side effects for the patient.
One method of medicating a stent involves the use of a polymeric carrier coated onto the surface of the stent. A composition including a solvent, a polymer dissolved in the solvent, and a therapeutic substance dispersed in the blend is applied to the stent by immersing the stent in the composition or by spraying the composition onto the stent. The solvent is allowed to evaporate, leaving on the stent strut surfaces a coating of the polymer and the therapeutic substance impregnated in the polymer.
A shortcoming of the above-described method of medicating a stent is the potential for coating defects. While some coating defects can be minimized by adjusting the coating parameters, other defects occur due to the nature of the interface between the stent and the apparatus on which the stent is supported during the coating process. A high degree of surface contact between the stent and the supporting apparatus can provide regions in which the liquid composition can flow, wick, and collect as the composition is applied. As the solvent evaporates, the excess composition hardens to form excess coating at and around the contact points between the stent and the supporting apparatus. Upon the removal of the coated stent from the supporting apparatus, the excess coating may stick to the apparatus, thereby removing some of the coating from the stent and leaving bare areas. Alternatively, the excess coating may stick to the stent, thereby leaving excess coating as clumps or pools on the struts or webbing between the struts.
Thus, it is desirable to minimize the amount of coating material that is deposited on the interface between the stent and the apparatus supporting the stent during the coating process to minimize coating defects. Accordingly, the present invention provides for a device for supporting a stent during the coating application process. The invention also provides for a method of coating the stent supported by the device.
The present invention provides an apparatus for supporting a stent. The apparatus includes a mounting assembly for supporting a stent during a process of applying a coating substance to the stent. The mounting assembly prevents the formation of the coating or at least minimizes the amount or thickness of the coating that can be formed on the regions of the stent where the mounting assembly is in contact with the stent.
In one embodiment, the mounting assembly includes a mounting member for supporting the stent and a shield member for providing a barrier between a selected area of the stent and a coating applicator. In another embodiment, the mounting assembly includes a first member for supporting the stent at a first end, a second member for supporting the stent at a second end, a third member connecting the first member to the second member and extending through the longitudinal bore of the stent, and a shield member for providing a barrier between a selected area of the stent and a coating applicator.
In still another embodiment, the mounting assembly includes a shielding member capping over one end of the stent without being in contact with the surface of the stent. In another embodiment, the mounting assembly includes a mounting member for supporting the stent and a shield member supported by the mounting member for creating a barrier between a portion of the stent and a coating applicator. In such an embodiment, the position of the shield member on the mounting member can be adjusted so as to allow a user to modify the area over which the shield member covers the stent.
In yet another embodiment, the mounting assembly includes a first member having a first coning end that can be at least partially inserted within a first end of the stent and a second member having a second coning end that can be at least partially inserted within an opposing second end of the stent, the coning ends being in contact with the ends of the stent. In such an embodiment, the mounting assembly further includes a third member connecting the first member to the second member and shielding members supported by the first and second members for reducing or eliminating the amount of the coating substance that is applied to the first and second ends of the stent.
Also provided is an assembly for supporting a stent during the coating process. The assembly includes means for minimizing or eliminating the amount of coating material that can be applied to a designated area of the stent during the coating process. In one embodiment, the means is defined by a hollow body capable of surrounding a region of the stent without being in contact with the surface of the stent. In another embodiment, the amount of coating material can be minimized or eliminated at the regions where the stent is in contact with the assembly.
The present invention additionally provides a method of coating a stent. The method includes mounting a stent on a support assembly, wherein the support assembly is configured to reduce or eliminate the amount of coating that is applied to the regions where the stent is in contact with the support assembly. The method also includes applying a coating material to the stent for forming a coating.
In one embodiment, the act of applying includes spraying the coating material onto the stent. In another embodiment, the act of applying a coating includes applying the coating material to a stent while rotating the stent about the longitudinal axis of the stent. In another embodiment, the act of applying a coating includes applying the coating material to a stent while moving the stent in a linear direction about the longitudinal axis of the stent.
Referring to
Referring to
The outer diameter of mandrel 24 can be smaller than the inner diameter of stent 10 so as to prevent the outer surface of mandrel 24 from making contact with the inner surface of stent 10. A sufficient clearance between the outer surface of mandrel 24 and the inner surface of stent 10 should be provided to prevent mandrel 24 from obstructing the pattern of the stent body during the coating process. By way of example, the outer diameter of mandrel 24 can be from about 0.010 inches (0.254 mm) to about 0.017 inches (0.432 mm) when stent 10 has an inner diameter of between about 0.025 inches (0.635 mm) and about 0.035 inches (0.889 mm).
Lock member 26 includes a coning end portion 42 having an inwardly tapered angle φ2. Angle φ2 can be the same as or different than the above-described angle φ1. A second end 44 of mandrel 24 can be permanently affixed to lock member 26 if end 40 is disengagable from support member 22. Alternatively, in accordance with another embodiment, mandrel 24 can have a threaded second end 44 for screwing into a bore 46 of lock member 26. Bore 46 can be of any suitable depth that would allow lock member 26 to be incrementally moved closer to support member 22. Bore 46 can also extend completely through lock member 26. Accordingly, stents 10 of any length can be securely pinched between support and lock members 22 and 26. In accordance with yet another embodiment, a non-threaded second end 44 and bore 46 combination is employed such that second end 44 can be press-fitted or friction-fitted within bore 46 to prevent movement of stent 10 on mounting assembly 20.
Mounting assembly 20 supports stent 10 via coning end portions 36 and 42.
Shields 28A and 28B provide a circumferential barrier around the peripheral ends of stent 10, particularly over the area where stent 10 is in physical contact with coning end portions 36 and 42. Shields 28A and 28B can be permanently affixed to support member 22 and/or lock member 26. Alternatively, in a more useful commercial embodiment, shields 28A and 28B can be adjustably supported by members 22 and/or 26.
In one embodiment, shields 28A and 28B can be defined by a hollow body 48 having a first section or overhang 50 that is configured to extend over at least a portion of stent 10. Overhang 50 should have an inner diameter d1 that is larger than the outer diameter of stent 10, in a mount position on mounting assembly 20, so as to create a sufficient gap 52 between shields 28A and 28B and the outer surface of stent 10 for eliminating any contact with the deposited coating. Gap 52 can be from about 0.003 inches (0.08 mm) to about 0.08 inches (about 2.03 mm), typically about 0.04 inches (about 1.02 mm), in measurement. Care should be taken, however, to ensure that gaps 52 are not so large as to allow the composition to access the stent 10-mounting assembly 20 interface.
Hollow body 48 can also include a second section 54 for adjustably receiving the non-coned portions of members 22 and 26. For example, second section 54 and non-coned portions of support and lock members 22 and 26 can be threaded such that the clockwise or counterclockwise rotation of shields 28A and 28B would allow the user to move shields 28A and 28B towards or away from stent 10. Thus, the area over stent 10 that is sheltered by overhang 50 can be adjusted. Hollow body 48 and second section 54 can also be integral parts of the non-coned portions of support and lock members 22 and 26.
Shields 28A and 28B function to minimize coating defects at the ends of stent 10 by limiting or eliminating the application of the coating substance to the ends of stent 10. The presence of shields 28A and 28B causes the coating to be thinner (or completely eliminated) on the surface of stent 10 over which shields 28A and 28B are hung, as compared to the surface of stent 10 that is not screened by shields 28A and 28B. Accordingly, the area of stent 10 over which shields 28A and 28B are extended should be selected to yield a suitable balance between reduction of the potential for coating defects at the ends of stent 10 and uniformity of the coating thickness. Further, appropriate selection of gap 52 and overhang 50, taking into account the distance between the spray nozzle and stent 10, can facilitate a gradual decrease in the coating thickness at the ends of stent 10 beneath overhang 50 as opposed to an abrupt void of coating near the shielded stent ends.
The following method of application is being provided by way of illustration and is not intended to limit the embodiments of mounting assembly 20 of the present invention. A spray apparatus, such as EFD 780S spray device with VALVEMATE 7040 control system (manufactured by EFD Inc., East Providence, R.I.), can be used to apply a composition to a stent. EFD 780S spray device is an air-assisted external mixing atomizer. The composition is atomized into small droplets by air and uniformly applied to the stent surfaces. The atomization pressure can be maintained at a range of about 5 psi to about 20 psi. The droplet size depends on such factors as viscosity of the solution, surface tension of the solvent, and atomization pressure. Other types of spray applicators, including air-assisted internal mixing atomizers and ultrasonic applicators, can also be used for the application of the composition.
During the application of the composition, a stent supported by mounting assembly 20 can be rotated about the stent's central longitudinal axis. Rotation of the stent can be from about 1 rpm to about 300 rpm, more narrowly from about 50 rpm to about 150 rpm. By way of example, the stent can rotate at about 120 rpm. The stent can also be moved in a linear direction along the same axis. The stent can be moved at about 1 mm/second to about 12 mm/second, for example about 6 mm/second, or for a minimum of at least two passes (i.e., back and forth past the spray nozzle). The flow rate of the solution from the spray nozzle can be from about 0.01 mg/second to about 1.0 mg/second, more narrowly about 0.1 mg/second. Multiple repetitions for applying the composition can be performed, wherein each repetition can be, for example, about 1 second to about 10 seconds in duration. The amount of coating applied by each repetition can be about 0.1 micrograms/cm2 (of stent surface) to about 10 micrograms/cm2, for example less than about 2 micrograms/cm2 per 5-second spray.
Each repetition can be followed by removal of a significant amount of the solvent(s). Depending on the volatility of the particular solvent employed, the solvent can evaporate essentially upon contact with the stent. Alternatively, removal of the solvent can be induced by baking the stent in an oven at a mild temperature (e.g., 60░ C.) for a suitable duration of time (e.g., 2–4 hours) or by the application of warm air. The application of warm air between each repetition minimizes coating defects and minimizes interaction between the active agent and the solvent. The temperature of the warm air can be from about 30░ C. to about 60░ C., more narrowly from about 40░ C. to about 50░ C. The flow rate of the warm air can be from about 20 cubic feet/minute (CFM) (0.57 cubic meters/minute (CMM)) to about 80 CFM (2.27 CMM), more narrowly about 30 CFM (0.85 CMM) to about 40 CFM (1.13 CMM). The warm air can be applied for about 3 seconds to about 60 seconds, more narrowly for about 10 seconds to about 20 seconds. By way of example, warm air applications can be performed at a temperature of about 50░ C., at a flow rate of about 40 CFM, and for about 10 seconds. Any suitable number of repetitions of applying the composition followed by removing the solvent(s) can be performed to form a coating of a desired thickness or weight. Excessive application of the polymer in a single repetition can, however, cause coating defects.
Operations such as wiping, centrifugation, or other web clearing acts can also be performed to achieve a more uniform coating. Briefly, wiping refers to the physical removal of excess coating from the surface of the stent; and centrifugation refers to rapid rotation of the stent about an axis of rotation. The excess coating can also be vacuumed off of the surface of the stent.
In accordance with one embodiment, the stent can be at least partially pre-expanded prior to the application of the composition. For example, the stent can be radially expanded about 20% to about 60%, more narrowly about 27% to about 55%—the measurement being taken from the stent's inner diameter at an expanded position as compared to the inner diameter at the unexpanded position. The expansion of the stent, for increasing the interspace between the stent struts during the application of the composition, can further prevent "cob web" formation between the stent struts.
In accordance with one embodiment, the composition can include a solvent and a polymer dissolved in the solvent and optionally a wetting fluid. The composition can also include active agents, radiopaque elements, or radioactive isotopes. Representative examples of polymers that can be used to coat a stent include ethylene vinyl alcohol copolymer (commonly known by the generic name EVOH or by the trade name EVAL), poly(hydroxyvalerate); poly(L-lactic acid); polycaprolactone; poly(lactide-co-glycolide); poly(hydroxybutyrate); poly(hydroxybutyrate-co-valerate); polydioxanone; polyorthoester; polyanhydride; poly(glycolic acid); poly(D,L-lactic acid); poly(glycolic acid-co-trimethylene carbonate); polyphosphoester; polyphosphoester urethane; poly(amino acids); cyanoacrylates; poly(trimethylene carbonate); poly(iminocarbonate); copoly(etheresters) (e.g. PEO/PLA); polyalkylene oxalates; polyphosphazenes; biomolecules, such as fibrin, fibrinogen, cellulose, starch, collagen and hyaluronic acid; polyurethanes; silicones; polyesters; polyolefins; polyisobutylene and ethylene-alphaolefin copolymers; acrylic polymers and copolymers; vinyl halide polymers and copolymers, such as polyvinyl chloride; polyvinyl ethers, such as polyvinyl methyl ether; polyvinylidene halides, such as polyvinylidene fluoride and polyvinylidene chloride; polyacrylonitrile; polyvinyl ketones; polyvinyl aromatics, such as polystyrene; polyvinyl esters, such as polyvinyl acetate; copolymers of vinyl monomers with each other and olefins, such as ethylene-methyl methacrylate copolymers, acrylonitrilestyrene copolymers, ABS resins, and ethylene-vinyl acetate copolymers; polyamides, such as Nylon 66 and polycaprolactam; alkyd resins; polycarbonates; polyoxymethylenes; polyimides; polyethers; epoxy resins; polyurethanes; rayon; rayon-triacetate; cellulose; cellulose acetate; cellulose butyrate; cellulose acetate butyrate; cellophane; cellulose nitrate; cellulose propionate; cellulose ethers; and carboxymethyl cellulose.
"Solvent" is defined as a liquid substance or composition that is compatible with the polymer and is capable of dissolving the polymer at the concentration desired in the composition. Examples of solvents include, but are not limited to, dimethylsulfoxide (DMSO), chloroform, acetone, water (buffered saline), xylene, methanol, ethanol, 1-propanol, tetrahydrofuran, 1-butanone, dimethylformamide, dimethylacetamide, cyclohexanone, ethyl acetate, methylethylketone, propylene glycol monomethylether, isopropanol, isopropanol admixed with water, N-methyl pyrrolidinone, toluene, and combinations thereof.
Wetting fluid can be used to enhance the wetting of the composition or to increase the capillary permeation of the composition. Capillary permeation is the movement of a fluid on a solid substrate driven by interfacial energetics. Capillary permeation is quantitated by a contact angle, defined as an angle at the tangent of a droplet in a fluid phase that has taken an equilibrium shape on a solid surface. A low contact angle means a higher wetting liquid. A suitably high capillary permeation corresponds to a contact angle less than about 90░. Representative examples of wetting fluid include tetrahydrofuran (THF), dimethylformamide (DMF), 1-butanol, and n-butyl acetate.
The active agent could be for inhibiting the activity of vascular smooth muscle cells. More specifically, the active agent can be aimed at inhibiting abnormal or inappropriate migration and/or proliferation of smooth muscle cells for the inhibition of restenosis. The active agent can also include any substance capable of exerting a therapeutic or prophylactic effect in the practice of the present invention. For example, the agent can be for enhancing wound healing in a vascular site or improving the structural and elastic properties of the vascular site. Examples of agents include antiproliferative substances such as actinomycin D, or derivatives and analogs thereof (manufactured by Sigma-Aldrich 1001 West Saint Paul Avenue, Milwaukee, WI 53233; or COSMEGEN available from Merck). Synonyms of actinomycin D include dactinomycin, actinomycin IV, actinomycin I1, actinomycin X1, and actinomycin C1. The active agent can also fall under the genus of antineoplastic, antiinflammatory, antiplatelet, anticoagulant, antifibrin, antithrombin, antimitotic, antibiotic, antiallergic and antioxidant substances. Examples of such antineoplastics and/or antimitotics include paclitaxel (e.g. TAXOL« by Bristol-Myers Squibb Co., Stamford, Conn.), docetaxel (e.g. Taxotere«, from Aventis S.A., Frankfurt, Germany), methotrexate, azathioprine, vincristine, vinbiastine, fluorouracil, doxorubicin hydrochloride (e.g. Adriamycin« from Pharmacia & Upjohn, Peapack N.J.), and mitomycin (e.g. Mutamycin« from Bristol-Myers Squibb Co., Stamford, Conn.). Examples of such antiplatelets, anticoagulants, antifibrins, and antithrombins include sodium heparin, low molecular weight heparins, heparinoids, hirudin, argatroban, forskolin, vapiprost, prostacyclin and prostacyclin analogues, dextran, D-phe-pro-arg-chloromethylketone (synthetic antithrombin), dipyridamole, glycoprotein IIb/IIIa platelet membrane receptor antagonist antibody, recombinant hirudin, and thrombin inhibitors such as Angiomax™ (Biogen, Inc., Cambridge, Mass.). Examples of such cytostatic or antiproliferative agents include angiopeptin, angiotensin converting enzyme inhibitors such as captopril (e.g. Capoten« and Capozide« from Bristol-Myers Squibb Co., Stamford, Conn.), cilazapril or lisinopril (e.g. Prinivil« and Prinzide« from Merck & Co., Inc., Whitehouse Station, N.J.), calcium channel blockers (such as nifedipine), colchicine, fibroblast growth factor (FGF) antagonists, fish oil (omega 3-fatty acid), histamine antagonists, lovastatin (an inhibitor of HMG-CoA reductase, a cholesterol lowering drug, brand name Mevacor« from Merck & Co., Inc., Whitehouse Station, N.J.), monoclonal antibodies (such as those specific for Platelet-Derived Growth Factor (PDGF) receptors), nitroprusside, phosphodiesterase inhibitors, prostaglandin inhibitors, suramin, serotonin blockers, steroids, thioprotease inhibitors, triazolopyrimidine (a PDGF antagonist), and nitric oxide. An example of an antiallergic agent is permirolast potassium. Other therapeutic substances or agents which may be appropriate include alpha-interferon, genetically engineered epithelial cells, rapamycin and dexamethasone. Exposure of the active ingredient to the composition should not adversely alter the active ingredient's composition or characteristic. Accordingly, the particular active ingredient is selected for compatibility with the solvent or blended polymer-solvent.
Examples of radiopaque elements include, but are not limited to, gold, tantalum, and platinum. An example of a radioactive isotope is P32. Sufficient amounts of such substances may be dispersed in the composition such that the substances are not present in the composition as agglomerates or flocs.
While particular embodiments of the present invention have been shown and described, it will be obvious to those skilled in the art that changes and modifications can be made without departing from this invention in its broader aspects. Therefore, the appended claims are to encompass within their scope all such changes and modifications as fall within the true spirit and scope of this invention.
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Published on Wednesday, January 12 2011 15:01
Arctic winds blew in six to nine inches of snow over the weekend, finally giving Lyons the look of a winter wonderland. Temperatures dropped into the single digits at night, but things should be warming up by the weekend.
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Published on Thursday, January 06 2011 00:00
In full disclosure, I am a Trustee for the Town of Lyons, a patient advocate member of the Department of Revenue's (DoR) Medical Marijuana Working Group, I am a patient myself, a caregiver, and a current business license holder. At this time I have NO financial interest in any medical marijuana business. I write this as an individual member of these various communities. I don't speak for the Board of Trustees (BoT), and I don't speak for anyone else but myself.
This week I want to provide the reader with some detailed information about cannabis research in the United States, and how cannabinoids work in the animal/human body.
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Published on Thursday, December 16 2010 00:00
In the interest of full disclosure, let it be known that the author of this article is married to the Mayor.In a special meeting on Monday night the Lyons Board of Trustees (BOT), per regulations by the State of Colorado, adopted the Town's budget for 2011. On
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Published on Thursday, January 06 2011 00:00
In the interest of full disclosure, let it be known that the author of this article is married to the Mayor.The room was so empty at Monday's Board of Trustees (BOT) meeting, one might have legitimately assumed
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Published on Thursday, December 16 2010 00:00
Perhaps area educators should be handing out more homework assignments these days, because some kids definitely have a little too much time on their
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It's time to play house! My Dreamy Dollhouse is packed with fun details like a gliding elevator and furniture pieces that make sound at the push of a button. This sturdy mansion was designed to withstand years of use and makes a great gift for any young girl. Features include:
- 14 pieces of furniture, including a grand piano and a hanging plant
- Gliding elevator takes dolls to the first, second or third floor
- Made of composite wood products
- Packaged with detailed, step-by-step assembly instructions
- Large enough that multiple children can play at once
- Piano plays music, toilet makes flushing sound, lamp lights up
- Batteries included
Age Range: 3+Shipping Note: This item ships directly from the manufacturer within contiguous United States only. Cannot be shipped to AK/HI, PO boxes, US territories, or APO/FPO addresses.


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Improving Google Maps
In 2013, we previewed a new version of desktop Maps, completely rewritten on an upgraded and modern platform for a richer, more engaging, and more helpful mapping experience. Since then, we've been continually improving the product, and will soon be rolling it out to everyone.
This update provides a number of benefits, including easier trip planning, more accurate traffic data, easier ways to explore new areas, and the ability to get you where you're going with better search, directions, Street View imagery and more.
What's changing?
- Soon, the updated version of Google Maps will become your desktop Maps experience. You'll no longer be able to use the older, classic Google Maps.
- Any information you have saved using Google Maps, will continue to be reflected, including locations like home and work addresses.
- If your browser or operating system don't meet the requirements necessary to run this new version of Maps, we may move you to "Lite mode" – a streamlined version of Maps.
Common questionsWhat's different in the new Maps?
It's now easier to plan your next trip, check live traffic conditions, discover what's happening around town, and learn about a new area. The updated Maps will help you:
Make smarter decisions. Search for "coffee" in your neighborhood, and you'll be able to see results right on the map. When you click on a cafe, the map will suggest related results that you may not have known about.
Get where you're going, faster. Car? Bike? Train? Find the most efficient route for you, with your best options laid out on the map, including the time and distance for each route. And with real-time traffic reports and Street View previews, you'll become a commuting ninja.
See the world from every angle. Rich imagery takes you to notable landmarks, sends you flying above mountains in 3D, and gives you a sneak peek of businesses you plan to visit. The "carousel" at the bottom of the map makes all this imagery easy to access, so you can explore the world with a click.
After the update you will no longer be able to switch back to or access classic Maps.
You can continue to help improve the Maps experience by sending us feedback.
You can still access the information that matters most to you from the new Maps. Learn more about:


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Toys R Us just outraged a lot of moms at the worst possible time, the approaching holiday shopping season. And it would have been so avoidable had they just appreciated the perspective of their audience. Let me set the stage here. I am a big fan of what I like to call "Reality Pranks," or live stunts that brands play on people (or between people) in order to make a larger branded point. These pranks are shot live and then edited into sometimes compelling films.
But Reality Pranks are inherently risky endeavors. Let's just say they're not designed to generate responses like these on the Toys R Us Facebook Facebookpage:
This ad makes me weep for the kind of values we are passing down to future generations. - Kelly Brown
Very disappointed in this ad. Its sole purpose is to downplay the excitement that living nature offers and substitute artificial commercial toys as enjoyment . . . Not a good life strategy! - Marquita Manley
Worst possible message ever! Using a green bus from a "tree foundation" to promote materialism? Shame shame on you. Never shop there again! - Sharon Bowman
And this Facebook-page slaying goes on and on and on, in stark contrast to the way the film was served up in the original post by Toys R Us: "How did we make all their wishes come true? Watch & see!"
Watch and see for yourself:
Reality Prank Makes A Mother Of A Mistake.
It's a Reality Prank, for sure. There's a foil – the kids. There's a prank – the actor who at first appears to be a forest ranger but is actually a Toys R Us representative (well, actually he's an actor who tries desperately to be Ben Stiller, but let's move on). It's "reality" in that it's real kids with real reactions. And it's filmed and edited very well. I actually liked it. But I am not the intended audience.
In order for this film to work, they needed to get a rise from the kids, so they decided to bore the kids senseless with an iconic and "boring" topic. So far, so good. But do they take on, I dunno, a boring symphony? That's an iconic yawner for kids. No. A tour of a government building? Nope. A cold, quiet museum? Nadda.
No, they take on Mother Nature and, in the process, provoke the nature of mothers.
The Female Marketing Experts Agree. This Reality Prank Backfired.
I learned about this ad from one of my female Creative Experts at Ideasicle, Lisa Taylor. She sent me an IM on Facebook with the YouTube link. Her comment, as only she could put it,
Marketing-wise, they're leveraging a classic and totally valid conflict scenario to make the children's enthusiasm more emotionally justified after the reveal. I just wish the element of surprise wasn't pitted against elements of nature.
Being a guy, I totally missed that point. Curious, I got the perspective of a parenting expert and publisher, Liz Gumbinner. She is widely known as the authority on marketing to moms with her "Mom 101" and " Cool Mom Picks" blogs. She also is an ex-Deutsch freelance creative director, so knows a thing or two about communications. She piled on,
I can't imagine why a major toy retailer would want to alienate parents and educators just before the holidays by promoting the idea that learning is lame, forest rangers are lame, and field trips are lame.
Now, let me stop there for a second. I thought the ad was pretty good. Not the best Reality Prank I'd ever seen, but a nice departure for Toys R Us and what I thought was a good risk taken. But, again, I'm a guy. I don't matter. It's not my perspective with which Toys R Us is trying to connect.
So my next stop was Kat Gordon, creative director at Maternal Instinct and founder of the 3% Conference, an organization devoted to changing the fact only 3% of all creative directors at ad agencies are women. Her view is that because of this "3% Problem," advertising, in general, is missing the female perspective and it often shows. So her assessment of the Toys R Us ad wasn't too surprising,
My gut says that a seasoned parent definitely did not write this campaign. I think a father or a mother — of kids at least the age of those in the commercial — would know better than try to fly this up the flagpole with other parents.
But it gets worse. The North American Association For Environmental Education took it up a notch with an open letter to Toys R Us. Here's a key excerpt:
While you may say that these were the real reactions of the kids, we question the method in which you presented the nature trip in order to get the "bored" responses, as it is our experience that children, particularly those from urban areas, are delighted at the chance to connect with nature and explore.
The NAAEE doesn't even believe the kids' reactions were real. Yikes.
The Reality Of Reality Pranks: High Risk, High Reward.
The nature of a Reality Prank is that you're not in complete control. There's a whopping variable that you're hoping to manage – the unsuspecting participants' reactions. But when it's done well, it can be to great effect:
LG Ultra HD TV – LG replaces an office "window" with a giant LG Ultra HD TV and then shows what looks like a meteor hitting the city outside to innocent interviewers in the room. Hilarity ensues.
Samsung Stare Down – Samsung stages a contest of sorts in a highly trafficked area where people can challenge its new technology that tracks where the viewer is looking. It's a stare down. But the lengths Samsung goes to in order to distract the contestants is fantastic, making the real reactions of the on-lookers even more compelling.
Carlsberg Challenges True Friendship – Carlsberg Carlsberg gets real friends to test their friendship with each other by staging an elaborate scheme. Any more would give it away, but it's great and it is way beyond the convention of claiming that this beer is for good friends.
Each of these examples stares down the barrel of danger in some way. And it's that danger that is the power of the genre, and what makes the resulting films so compelling.
But that wasn't the problem here (the Toys R Us ad got a great reaction from the kids). No, this problem was utterly avoidable. Toys R Us was so blind to the perspective of its audience and, as a result, so politically incorrect that this guy can only suggest that Toys R Us either bring in some female perspective into the creative process or stick to the sandbox of traditional advertising from now on.


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at Rockford IceHogs (21-6-3-5)
Rockford MetroCentre
7:30 p.m.
Sat., Jan. 5
at Milwaukee Admirals (17-13-1-1)
Bradley Center
8 p.m.
To watch or listen to the action live online, log on to www.chicagowolves.com
Sixteen of Chicago's last 31 goals over the last six games have been recorded on the power play; the Wolves have netted an AHL-high 52 man-advantage markers in 32 games this season and rank second overall on the power play at 24.4 percent
(52 of 213).
Jason Krog: Currently on a team season-high nine-game point streak, recording 20 points (5G, 15A) during that span, which includes 14 (4G, 10A) over the last five tilts ... Leads the AHL with 32 assists and 46 points in 32 contests and shares 10th with 14 goals ... Accrued 126 points (40G, 86A) in 76 career regular-season games with Chicago over the last two seasons, which includes notching at least one point 67 times
Darren Haydar: Netted multiple points in five straight games since being assigned by the Atlanta Thrashers, collecting two goals and 11 assists ... Potted his first career NHL points (G, 7A) in 16 matchups with Atlanta earlier this season ... Ranks 13th all-time in franchise history with 135 points (43G, 92A) in 79 career outings with Chicago over the past two seasons
Joel Kwiatkowski: Recorded three goals in Friday's win at Milwaukee, becoming the first defenseman in franchise history to notch a hat trick ... Shares the lead among AHL defensemen with 10 goals and ranks third with 26 points in 32 games ... Leads the squad with a +10 plus/minus rating ... Notched 13 points (6G, 7A) in 12 games during December
Brett Sterling: Ranks second in the AHL with 19 goals in just 24 games after
leading the league with 55 markers during his rookie season last year ... Notched a point in eight of his last nine games (6G, 4A) ... Ranks fourth on Chicago with 30 points
Ondrej Pavelec: Registered wins in six straight starts, racking up a 2.93 goals-against average and a .903 save percentage during that span ... Shares second among AHL rookie goaltenders with eight wins and has racked up an 8-3-0 record with a 3.06 goals-against average and a .894 save percentage in 11 appearances with the Wolves this season
For complete team statistics, click here
-- The Wolves rank second in the AHL with 23 wins, tied for the most in team history through 32 games; Chicago's 47 points trails only Rockford (50 points), which has played three more games, for the West Division lead.
-- Defenseman Joel Kwiatkowski's three-goal effort last Friday marked the team's fourth hat trick of the season, three of which have been recorded on the road; prior to Friday, Chicago's previous 68 all-time hat tricks were tallied by forwards.
-- Four Wolves are currently in the top 20 in AHL scoring (KROG, SCHULTZ, MARTINS, STERLING).
-- Chicago leads the AHL with an average of 3.84 goals per game, which includes lighting the lamp at least four times in 20 of its 32 contests.
-- Fifteen of Chicago's 32 games this season have been decided by one goal (46.9 percent), which includes two 4-3 victories last week; the Wolves have accrued an 11-3-1-0 record in games decided by one marker this season.
-- The Wolves allowed just one power-play goal in each of their three matchups last week (13 of 16); Chicago's 84.8 percent penalty kill efficiency ranks 10th in the AHL.
The Wolves share second in the AHL with 12 home wins and have registered a
12-4-0-0 mark at the Allstate Arena this season; Chicago did not post its 12th home victory last season until March 4.
Sat., Dec. 29
Quad City 5, (at) Chicago 2
-- Down early, Chicago rallied to tie the game at two before falling 5-2 against the Quad City Flames at the Allstate Arena
-- Center Jason Krog and defenseman Brian Fahey posted the Wolves' goals with right wing Darren Haydar assisting on both tallies
-- Netminder Robert Gherson registered 33 saves on 36 shots
Fri., Dec. 28
Chicago 4, (at) Milwaukee 3
-- Chicago came from behind twice early in the contest before holding on for a 4-3 win over the Milwaukee Admirals at the Bradley Center
-- Defenseman Joel Kwiatkowski potted three goals while right wing Darren Haydar dished out three assists
-- Goaltender Ondrej Pavelec recorded 28 saves on 31 shots
Thu., Dec. 27
(at) Chicago 4, Rockford 3 (OT)
-- Left wing Brett Sterling posted his second straight overtime-winning goal as the Wolves earned a 4-3 victory over the Rockford IceHogs at the Allstate Arena
-- STERLING (PPG, A) and linemates Jason Krog (G, 2A) and Darren Haydar (2A) each netted multiple points while defenseman Nathan Oystrick added a power-play goal and an assist
-- Goaltender Ondrej Pavelec tallied 27 saves on 30 shots


text:
Hey everyone,
This is baby number 3 for us. I had my daughter in 2008 and was induced 4 weeks early due to severe pre eclampsia. I have normally low blood pressure and they never checked my urine there after feeling off for a couple weeks one day I just couldn't take it anymore and went to L&D. There they checked my urine and even though my BP wasn't super bad 120-125/850-85ish I had severe spillage in protein on the dipstick one 24 hour urine later at the hospital and I was induced immediately. They ended up checking it after 12 hours because my BP started to climb higher and I already had more than 5 grams in it.
My second pregnancy I was fine my whole pregnancy and then just at the very end I started spilling a little protein in my urine and my BP started to go up slightly so I was induced at 40 weeks with him.
Onto this pregnancy I am currently 27 weeks pregnant with baby number 3 and so far my pregnancy has been pretty great. I am on day 3 of a severe headache that wont go away with tylenol. The headache is worse when I am standing up or walking but still there when I sit down. Oddly I actually have a 24 hour urine to do just to get a baseline reading so incase anything goes haywire they know where my numbers started at that I need to take in on friday (meaning tomorrow I'll be collecting everything). I checked my blood pressure and I can't remember the numbers but it looked fine (it was under 120/80.) Should I still be concerened seeing I can't shake this headache? Can pre-e really start this early? For those who have had it this early what was your treatment to get you to bake the baby longer if possible? What about in cases where there is proteina but blood pressure is stable? I have 2 other kids at home complete bedrest is impossible. I just don't know what to think. I am really starting to feel "off" almost like I'm coming down with something but it never hits fully or goes away fully. Any help/advice would be greatly appriciated.


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iPad 3G can make calls and send SMS messages with soon to be released jailbreak app [video]
If you have a burning desire to make phone calls or send SMS messages on your iPad 3G, you'll be happy to know that a group by the name of iPhoneIslam has demonstrated a jailbreak application that enables calls, SMS and FaceTime via phone number on an iPad 3G.
The hack will be called PhoneItiPad and should be available in the Cydia app store before WWDC. The hack requires no additional hardware but you obviously need a jailbroken iPad 3G. This means no iPad 2 support until there is a jailbreak released for that.
Once installed you get an iPhone dialler screen which unfortunately is just the iPhone version blown up 2x. It does look a little ropey; they are working on a full resolution version for this. SMS messages do work perfectly in full screen mode on the iPad. The demo video shows how it all works and it does look like a handy feature to have.
Take a look at the demo video after the break. Then pop back here and let us know if you would welcome the ability to use your iPad 3G as a phone?
Have something to say about this story? Leave a comment! Need help with something else? Ask in our forums!
Reader comments
iPad 3G can make calls and send SMS messages with soon to be released jailbreak app [video]
No need to have an iPhone any more - just carry and iPad in your pocket!
And the first text message you will get (for U.S.) is AT&T telling you to stop or they will switch you to a full calling plan for $150 a month.
haha good one!
Am I the only one wondering if this will actually be practical, at least for more than a few months? Once the carriers find out its happening - they will find a way to block it. Its the same thing as an iphone - if it doesnt have a specific calling/sms plan, it wont make calls or texts....
Dont get me wrong...I would die just for the text function. BiteSMS on my ipad - YES PLEASE!
I can already do this with an app from the actual AppStore.... Textfree plut voice.... Given that u have to pay for minutes u use... I prefer to use it for texting rather than to give AT&T more of my money each month...
He is making phone calls and texts using an actually phone number with a phone Sim card , not over 3G.
It is required to have a 3G iPad , so you can use a Sim card in it.
Viber/textfree plus voice are all great Apps but they are only using internet not actually minutes , which he is doing in this Video ;)
Best Luck
You can't do that already.I don't have a iPad. But I have a iPod touch. I send text and make free calls and text all the time from my iPod. Google voice and Vonage, you can't do that on iPad. I have no phone bill right now. Only thing you can't receive calls. But someone can call your google voice number, then just call them back. Winning
Not being cellphone carriers b$&@!
Glen, this is actual calling through the GSM network. Sure, you can skype people, but if they're not online, you won't reach them. This is a hack to enable normal calls and sms, like the iPhone does.
what app is it?.. i badly needed it... plsss
You can already use the iPad as a phone just use the Line2 app
i think this is really cool that this would work as a native app on the ipad 3g. i dont think that it'll hold like others have pointed out
Let's try to put things right.
To the folks talking about att blocking this it doesn't matter if they do. There are Many mvno out there airvoice, jolt, h20, redpocket, straight talk etc. and none of them require an unlocked phone, and none of them will care to block this either.
To the folks talking about 3G and voip already being there so that this new hack is unnecessary. Cleary you don't really use those voip apps as there performance on 3G is sketchy at best.
To the folks saying holding a big arse iPad next to your ear is impractical and dorky clearly you have not heard of speaker phone.
"To the folks saying holding a big arse iPad next to your ear is impractical and dorky clearly you have not heard of speaker phone."
Or a Bluetooth earpiece.
Having business phone call capabilities on the iPad, while taking notes, getting directions, processing over-the-phone credit cards, etc., would be fantastic.
When 99% of the visitors here only sit around playing and discussing gaming, what sort of possibilities would you expect them to imagine about this sort of thing? None.
Apple probably can...but will VZW and AT&T allow it.
If yu think that being able to use your I Pad 3 G as A phone is, "kool"
Than u should see what I can do on my toilet after 12:00 am.. Take A guess ? And it ain't taking A crap .
You can natively SMS with the iPad already (if your carrier supports it) with a jailbrak app called swirlySMS. Basta! No more talk of: i can already call with the this or that app from the appstore Please! that happens over data traffic. Different protocol than GSM network.
I have no data plan and can receive/send SMS. Soon, thanks to these guys I'll be able to make calls as well. WHITHOUT A DATA PLAN!
It's dumb for apple not to include this function in the fist place. All of people surf, check email etc.... using their phones, it's a voice/data plan. Should be able to do both on iPad. Oh an everyone here needs to understand all calls are digital (DATA) on mobile devices. At&t and verizon shouldn't block this or even care until you hit your data limit.
Can u plz tell me details, m new to ipad and want to make calls.
any one help I can't do it with my stuff of 4.3.2
Please I want to makephone call from I phone from iPad
I test it on an iPad 1 and works just great, I am still waiting since 4.3.3 to install it, now has support for 5.0.1, but only to ipad1 sooooo, still waiting, I will get rid of a lot of devices if I can use my iPad 2 as a Phone (BTW, my wife took my iPad 1 because now she can make calls...)
I've JB my ipad2 3G but unfortunately this app is not ready :(
I hope they'll be ready soon though.
Why all this fuss and fight. Don't be excited with this app. Just download Skype and you are in business. Jail breaking can just make you expensive gadget iPad vulnerable. Just chill Skype is just cool and you can do all your phone business through Skype - and it works all over the world. What more do you need people!
Well hello, skype might only applicable to those that have internet access.. How about ipad which highly dependable on wifi and no 3G! Or maybe u are stranded to a place which have no internet access.. Do u think skype might help? U still need this type of apps to make normal phone calls.
Hey! I know this is kinda off topic but I'd figured I'd ask. Would you be tsierented in trading links or maybe guest authoring a blog post or vice-versa? My website covers a lot of the same topics as yours and I feel we could greatly benefit from each other. If you happen to be tsierented feel free to shoot me an email. I look forward to hearing from you! Terrific blog by the way!
Hey There I very much liked reading your post. I'm thinking about writing my own blog soon Cheers.
Wow, that's clean. What does one do with a four-wheel-drive that clean? Certainly you don't take it off road or drive it in the snow!
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I always wonder about David..."Man after God's own heart." yet also permitted to have more than one wife. Even when he was young and not yet king. He married Abigail. I don't remember ever seeing in scripture that this was point out as being wrong??
The fact that Halifax/AXA are quibbling over a £30 difference in the two quotes is, frankly, mind-blowing. So we'd like to know the answer to this simple question: Were we expected to wait a week amid the insecurity of a shattered pane and then have something installed that we didn't want? I mention this because the Evander assessor had told us our Georgian bars would be replaced by new ones, which would have jarred with whiteness against our existing ones from 1987 which will, indeed, be used again.
I've been hankering after a scooter for years but simply refused to pay a premium for style. After being recommended I went to Direct Bikes and bought one – remarkably cheap compared to other makes. I've only had it two weeks but it's glorious and, touch wood, will keep me happy for years.