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- CIK cells (1)
- NSG mice (1)
- immunotherapy (1)
- leukemia (1)
- preclinical (1)
- rhabdomyosarcoma (1)
- Medizin (7)
- Georg-Speyer-Haus (2)
- Pharmazie (1)
- Hematopoietic chimerism after allogeneic stem cell transplantation: a comparison of quantitative analysis by automated DNA sizing and fluorescent in situ hybridization (2005)
- Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is performed mainly in patients with high-risk or advanced hematologic malignancies and congenital or acquired aplastic anemias. In the context of the significant risk of graft failure after allo-HSCT from alternative donors and the risk of relapse in recipients transplanted for malignancy, the precise monitoring of posttransplant hematopoietic chimerism is of utmost interest. Useful molecular methods for chimerism quantification after allogeneic transplantation, aimed at distinguishing precisely between donor's and recipient's cells, are PCR-based analyses of polymorphic DNA markers. Such analyses can be performed regardless of donor's and recipient's sex. Additionally, in patients after sex-mismatched allo-HSCT, fluorescent in situ hybridization (FISH) can be applied. Methods: We compared different techniques for analysis of posttransplant chimerism, namely FISH and PCR-based molecular methods with automated detection of fluorescent products in an ALFExpress DNA Sequencer (Pharmacia) or ABI 310 Genetic Analyzer (PE). We used Spearman correlation test. Results: We have found high correlation between results obtained from the PCR/ALF Express and PCR/ABI 310 Genetic Analyzer. Lower, but still positive correlations were found between results of FISH technique and results obtained using automated DNA sizing technology. Conclusions: All the methods applied enable a rapid and accurate detection of post-HSCT chimerism.
- Mesenchymal stromal cells for treatment of steroid-refractory GvHD: a review of the literature and two pediatric cases (2011)
- Severe acute graft versus host disease (GvHD) is a life-threatening complication after allogeneic hematopoietic stem cell transplantation. Human mesenchymal stromal cells (MSCs) play an important role in endogenous tissue repair and possess strong immune-modulatory properties making them a promising tool for the treatment of steroid-refractory GvHD. To date, a few reports exist on the use of MSCs in treatment of GvHD in children indicating that children tend to respond better than adults, albeit with heterogeneous results. We here present a review of the literature and the clinical course of two instructive pediatric patients with acute steroid-refractory GvHD after haploidentical stem cell transplantation, which exemplify the beneficial effects of third-party transplanted MSCs in treatment of acute steroid-refractory GvHD. Moreover, we provide a meta-analysis of clinical studies addressing the outcome of patients with steroid-refractory GvHD and treatment with MSCs in adults and in children (n = 183; 122 adults, 61 children). Our meta-analysis demonstrates that the overall response-rate is high (73.8%) and confirms, for the first time, that children indeed respond better to treatment of GvHD with MSCs than adults (complete response 57.4% vs. 45.1%, respectively). These data emphasize the significance of this therapeutic approach especially in children and indicate that future prospective studies are needed to assess the reasons for the observed differential response-rates in pediatric and adult patients. Additional file 1: MSCs expansion and release criteria.his file contains a detailed description of the MSCs expansion and release criteria for Case A and Case B.
- IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study (2011)
- In an ongoing clinical phase I/II study, 16 pediatric patients suffering from high risk leukemia/tumors received highly purified donor natural killer (NK) cell immunotherapy (NK-DLI) at day (+3) +40 and +100 post haploidentical stem cell transplantation. However, literature about the influence of NK-DLI on recipient's immune system is scarce. Here we present concomitant results of a noninvasive in vivo monitoring approach of recipient's peripheral blood (PB) cells after transfer of either unstimulated (NK-DLI(unstim)) or IL-2 (1000 U/ml, 9–14 days) activated NK cells (NK-DLI(IL-2 stim)) along with their ex vivo secreted cytokine/chemokines. We performed phenotypical and functional characterizations of the NK-DLIs, detailed flow cytometric analyses of various PB cells and comprehensive cytokine/chemokine arrays before and after NK-DLI. Patients of both groups were comparable with regard to remission status, immune reconstitution, donor chimerism, KIR mismatching, stem cell and NK-DLI dose. Only after NK-DLI(IL-2 stim) was a rapid, almost complete loss of CD56(bright)CD16(dim/−) immune regulatory and CD56(dim)CD16(+) cytotoxic NK cells, monocytes, dendritic cells and eosinophils from PB circulation seen 10 min after infusion, while neutrophils significantly increased. The reduction of NK cells was due to both, a decrease in patients' own CD69(−) NCR(low)CD62L(+) NK cells as well as to a diminishing of the transferred cells from the NK-DLI(IL-2 stim) with the CD56(bright)CD16(+/−)CD69(+)NCR(high)CD62L(−) phenotype. All cell counts recovered within the next 24 h. Transfer of NK-DLI(IL-2 stim) translated into significantly increased levels of various cytokines/chemokines (i.e. IFN-γ, IL-6, MIP-1β) in patients' PB. Those remained stable for at least 1 h, presumably leading to endothelial activation, leukocyte adhesion and/or extravasation. In contrast, NK-DLI(unstim) did not cause any of the observed effects. In conclusion, we assume that the adoptive transfer of NK-DLI(IL-2 stim) under the influence of ex vivo and in vivo secreted cytokines/chemokines may promote NK cell trafficking and therefore might enhance efficacy of immunotherapy.
- Sequential anti-cytomegalovirus response monitoring may allow prediction of cytomegalovirus reactivation after allogeneic stem cell transplantation (2012)
- Background: Reconstitution of cytomegalovirus-specific CD3+CD8+ T cells (CMV-CTLs) after allogeneic hematopoietic stem cell transplantation (HSCT) is necessary to bring cytomegalovirus (CMV) reactivation under control. However, the parameters determining protective CMV-CTL reconstitution remain unclear to date. Design and Methods: In a prospective tri-center study, CMV-CTL reconstitution was analyzed in the peripheral blood from 278 patients during the year following HSCT using 7 commercially available tetrameric HLA-CMV epitope complexes. All patients included could be monitored with at least CMV-specific tetramer. Results: CMV-CTL reconstitution was detected in 198 patients (71%) after allogeneic HSCT. Most importantly, reconstitution with 1 CMV-CTL per µl blood between day +50 and day +75 post-HSCT discriminated between patients with and without CMV reactivation in the R+/D+ patient group, independent of the CMV-epitope recognized. In addition, CMV-CTLs expanded more daramtaically in patients experiencing only one CMV-reactivation than those without or those with multiple CMV reactivations. Monitoring using at least 2 tetramers was possible in 63% (n = 176) of the patients. The combinations of particular HLA molecules influenced the numbers of CMV-CTLs detected. The highest CMV-CTL count obtained for an individual tetramer also changed over time in 11% of these patients (n = 19) resulting in higher levels of HLA-B*0801 (IE-1) recognizing CMV-CTLs in 14 patients. Conclusions: Our results indicate that 1 CMV-CTL per µl blood between day +50 to +75 marks the beginning of an immune response against CMV in the R+/D+ group. Detection of CMV-CTL expansion thereafter indicates successful resolution of the CMV reactivation. Thus, sequential monitoring of CMV-CTL reconstitution can be used to predict patients at risk for recurrent CMV reactivation.
- Wenn Zellen zu Medikamenten werden : neue Zelltherapien verbessern die Heilungschancen bei Leukämien (2013)
- Die Transplantation von Zellen aus dem Knochenmark oder von Stammzellen aus dem Blut gehört zu den bekanntesten Therapien bei Leukämie. Doch dabei treten Immunreaktionen als Nebenwirkung auf. Deshalb nehmen Forscher seit Kurzem auch die Transplantation bestimmter Immunzellen in den Blick. Im Labor gentechnisch aufgerüstet, werden sie zu äußerst effizienten "Krebs-Medikamenten".
- Cytotoxic capacity of IL-15-stimulated cytokine-induced killer cells against human acute myeloid leukemia and rhabdomyosarcoma in humanized preclinical mouse models (2012)
- Allogeneic stem cell transplantation (allo-SCT) has become an important treatment modality for patients with high-risk acute myeloid leukemia (AML) and is also under investigation for soft tissue sarcomas. The therapeutic success is still limited by minimal residual disease (MRD) status ultimately leading to patients' relapse. Adoptive donor lymphocyte infusions based on MRD status using IL-15-expanded cytokine-induced killer (CIK) cells may prevent relapse without causing graft-versus-host-disease (GvHD). To generate preclinical data we developed mouse models to study anti-leukemic- and anti-tumor-potential of CIK cells in vivo. Immunodeficient mice (NOD/SCID/IL-2Rγc−, NSG) were injected intravenously with human leukemic cell lines THP-1, SH-2 and with human rhabdomyosarcoma (RMS) cell lines RH41 and RH30 at minimal doses required for leukemia or tumor engraftment. Mice transplanted with THP-1 or RH41 cells were randomly assigned for analysis of CIK cell treatment. Organs of mice were analyzed by flow cytometry as well as quantitative polymerase chain reaction for engraftment of malignant cells and CIK cells. Potential of CIK cells to induce GvHD was determined by histological analysis. Tissues of the highest degree of THP-1 cell expansion included bone marrow followed by liver, lung, spleen, peripheral blood (PB), and brain. RH30 and RH41 engraftment mainly took place in liver and lung, but was also detectable in spleen and PB. In spite of delayed CIK cell expansion compared with malignant cells, CIK cells injected at equal amounts were sufficient for significant reduction of RH41 cells, whereas against fast-expanding THP-1 cells 250 times more CIK than THP-1 cells were needed to achieve comparable results. Our preclinical in vivo mouse models showed a reliable 100% engraftment of malignant cells which is essential for analysis of anti-cancer therapy. Furthermore our data demonstrated that IL-15-activated CIK cells have potent cytotoxic capacity against AML and RMS cells without causing GvHD.
- Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells : implications for adoptive immunotherapy after allogeneic stem cell transplantation (2010)
- Background: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines and investigated the mechanisms involved. Design and Methods: Peripheral blood mononuclear cells from six healthy donors were used to generate and expand cytokine-induced killer cells. The phenotype and composition of these cells were determined by multiparameter flow cytometry, while their cytotoxic effect against rhabdomyosarcoma cells was evaluated by a europium release assay. Results: Cytokine-induced killer cells efficiently lysed cells from both rhabdomyosarcoma cell lines. Antibody-mediated masking of either NKG2D molecule on cytokine-induced killer cells or its ligands on rhabdomyosarcoma cells (major histocompatibility antigen related chain A and B and UL16 binding protein 2) diminished this effect by 50%, suggesting a major role for the NKG2D molecule in rhabdomyosarcoma cell killing. No effect was observed after blocking CD11a, CD3 or TCRαβ molecules on cytokine-induced killer cells or CD1d on rhabdomyosar-coma cells. Remarkably, cytokine-induced killer cells used tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to activate caspase-3, as the main caspase responsible for the execution of apoptosis. Accordingly, blocking TRAIL receptors on embryonic rhabdomyosarcoma cell lines significantly reduced the anti-tumor effect of cytokine-induced killer cells. About 50% of T cells within the cytokine-induced killer population had an effector memory phenotype, 20% had a naïve phenotype and approximately 30% of the cells had a central memory phenotype. In addition, cytokine-induced killer cells expressed low levels of activation-induced markers CD69 and CD137 and demonstrated a low alloreactive potential. Conclusions: Our data suggest that cytokine-induced killer cells may be used as a novel adoptive immunotherapy for the treatment of patients with rhabdomyosarcoma after allogeneic stem cell transplantation.


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These are the bookings recorded for the Doris C. Gravat Detention Center for Nov. 21, 2013. Some of the people listed may not have actually spent time in jail if they posted bond and were released. Although those listed have been arrested and charged, that does not mean they have been found guilty. All bookings may be viewed online by visiting www.aikenstandard.com and clicking on the "Crime" tab.
Tamika Trent — driving under the influence
Ryan Morris — driving under the influence
Eric Liverman — disorderly conduct/gross intoxication
Purray Williams Jones — proof of insurance required, registration required, open container of beer/wine, allowing an unauthorized person to drive, contempt of magistrates court
Stephen Moseley — disorderly conduct/gross intoxication, resisting arrest
Jimpsey Johnson — breaking into motor vehicle, tanks or pumps where full lubricants are stored
Terry McManus — disregarding a traffic control device, driving under suspension first offense
Tommie Golding — false information to police/fire sentence, trespassing after notice sentence
Tami Johnson — simple possession of marijuana commitment
Richard Ridley — hold for probably cause hearing for general sessions court, hold for South Carolina Department of Correction's max out date 12/1/2013
Randy Currie — unlawful use of a telephone two counts
Andrew Green — open container of beer/wine, family court failure to appear, criminal domestic violence first, second and third offense
Ernest Hill — no moped tag bench warrant, no moped license bench warrant
Matthew McClain — hit and run with property damage
Andre Gibson — forgery value less than $10,000 general sessions court bench warrant two counts, hold for Johnston Police Department for criminal conspiracy warrant, open container bench warrant, violation of probation
Ferderica Banks — no vehicle license bench warrant two counts, no proof of ownership bench warrant, no South Carolina driver's license bench warrant, no proof of insurance bench warrant two counts, no driver's license in possession bench warrant, failure to change address bench warrant
Lewis Gaines Jr. — hold for South Carolina Department of Corrections max out date 11/27/2013, hold for general sessions court for probably cause order
Kenneth Eaves — malicious injury to animals or property $1,000 or less
Peter Schoeffler — driving without a license first offense bench warrant, violation of probation
Treshaun Brown — disorderly conduct/profanity
Dwayne Smith — shoplifting $1,000 or less
Terrance McKie — habitual offender, driving under suspension
Pedro Ortiz — shoplifting $1,000 or less
Joseph Trull — grand larceny $5,000 or more, hold for South Carolina Department of Corrections maxout date 11/27/2013
Brandon Smith — failure to pay per court order
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subset: commoncrawl


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If the Korean War of 1950 to 1953 that came close to taking my life has indeed been forgotten, certainly among the youth of our country, it may be due to its convenient omission by an educational system that is biased against United States involvement with democratic struggles of other countries across the globe. It could also be due to the fact that the war was never won. It might be time to turn off the soaps, the cartoons and the sports channels to have serious discussions with your children about the history that you and your grandfather experienced since the one proven fact of life is that history repeats itself.
The forgotten war, my war, the Korean War, cost over 52,000 young American lives, lost in a short three years, far more lives than it took 10 years to expend in the Vietnam conflict. The Korean War took place on a continent where thousands of rice paddies were tilled with human excrement! We could smell our waiting battlefields three miles at sea from the deck of the U.S.S. Mitchell, which was crammed with young U.S. Army, U.S. Air Force and U.S. Marines headed across the Pacific for over a year of bloody combat. We were on a mission that provided no time, no inclination for the drug abuse by soldiers that took place in Vietnam. Not in Korea, where you would fight every day, charge forward on frostbitten feet, retreat when you ran out of ammo, where you were lucky to have food every day, potable water, and sufficient ammunition.
Ours was a United Nations war with the United States suffering the preponderance of mutilated casualties. Canadians were the youngest – foolish with confidence – charging North Korean machine gun nests like the brave actors of a John Wayne movie – cut to pieces just as fast as their charge into action. The Aussies were tall, great fighters – hyper masculine with their show of courage – well trained with the bayonet, powerful enough to fire a Browning automatic with one hand while dragging a fallen brother with the other. The Brits were amazing! Taking cover from a barrage of incessant cannon fire, they would break for tea every day at the "proper" evening hour.
When potable water and mud-soiled tea bags became seriously scarce, they boiled their "bloody urine." We borrowed that foul trick and used it until the first snows blanketed our battalion, blessing us with a foot of God's clean white moisture. A surprising number of days were fought without food, but the lack of potable water brought sickness, weakness and, among the brave warriors, confused awareness that the richest nation in the world could not provide sufficient food and water for its fighting troops. We couldn't blame it entirely upon the hat salesman-turned-president Truman.
The North Koreans were wise enough to loft their cannon fire and strike at the rear of our division knowing that the water and food trucks were there. Half of the North Korean units were trained to fight at night knowing that American combat training was restricted to daylight. To sleep, we were advised to use dead North Korean bodies as protective cover with fixed bayonets at the ready and poised for their quietly creeping comrades. The Monsoon brought 40 days and 40 nights of incessant rain, pounding our helmets like a gentle machine gun. Years later, we survivors were amused at the statues that were sculpted for commemoration of our efforts. The soldiers were draped in sculpted raincoats. We were never issued those raincoats until a month before the peace talks at Panmunjom, three years after the first shot.
Our nation had elected a president who had no close combat experience in situations that drive a soldier to his most basic, primitive behavior. Thousands of young American boys were slaughtered, crossing the Pusan perimeter. Several of my high school friends were blown apart with sophisticated munitions. We had no flak jackets. Shrapnel that tore through so many of those young bodies were stamped with Russian printing. The Russians were our silent enemy. We were supplied with World War II Garande rifles and fixed bayonets, barely three feet in length and with sparsely limited bullet clips. The Chinese had rifles over a foot longer, far superior in a bayonet fight.
Our charging orders were "Three on One or run!" Those who didn't follow that directive were speared, their limp, lifeless bodies sunk into the human excrement that nurtured the odiferous Korean rice fields. In desperation, against intolerable cold that brought bitter frostbite, many Army personnel tore off the down-filled vests and fur hats from dead North Korean and Chinese soldiers to wear over their thin combat fatigues, which offered little protection against the bitter Korean winter!
In April of 1951, Truman vociferously fired one of our nation's greatest generals! Successfully striking with surprise from the northwest at Inchon, our heroic General MacArthur planned and executed a brilliant pincer movement, resulting in recapture of the capital, Seoul. He wanted our soldiers to push the North Koreans to the Chinese border after that successful show of strength, but President Truman angrily rejected the plan. MacArthur flew to Washington, pleading for permission to advance our troops to the Yalu River.
He begged our commander in chief to allow a show of strength that might have prevented the heavy onslaught of Chinese soldiers that soon overwhelmed us with their sheer number. Truman, jealous of MacArthur's popularity and worried about his competition in the next election, relieved the great combat leader of his command. The morale of the troops after that shocking dismissal compelled some to throw down their weapons in disgust. A politician was controlling our progress. MacArthur, the adulated head of our finest forces, had been disgraced. Many went so far as to throw their hands up and surrender. They were never seen again.
"Stand down!" was Truman's order. "Ours is only a police action. Hold at the 38th parallel until your ammo runs out. . . ." It was a foolish way to fight a war.
"Stand down!" Does that directive sound familiar? It's the same cowardly command that we now know was delivered to our brave defenders of the American Embassy in Benghazi, Libya, while our president and his staff watched the horror of their demise in their White House situation room, real time video of the bloody scene delivered by drone. (This evidence is now confirmed by retired Army Lt. Colonel Tony Shaffer.) One brave soldier disobeyed the official command in an effort to rescue the survivors. Ty Woods, a Navy Seal, was trained to never leave an American in danger when you have the courage and means to rescue them. He saved 30 shocked diplomatic employees and, unfortunately, gave his life for that. Ty recognized that a U.S. diplomat compound is American soil! Ty was a patriot. I would have felt secure with him watching my back.
In this day and time, we are confronted with a savage enemy whose chauvinistic men honestly believe that their 72 virgins' award awaits the sacrifice of their lives for Jihad. This is a difficult enemy, one that will only respect power and confidence. Our congress should pass a law that the commander in chief of our fighting forces be a strong patriot, one preferably with combat experience, to guide his decisions in the defense of our country and in the defense of the principles ". . . for which it stands . . ."
Seven of us returned from the forgotten war from a brave division of 340. "Stand down?" I choose to stand up with real men like Ty Wood, with patriots who are willing to defend flag and country.
May God bless all American combat veterans, those who have passed and those who are still plagued by horrific drams of incessant hell on Earth. We may be old and a bit wrinkled but we will die as patriots. God help us deal with the thundering dreams.
Sgt. Frank Covino of Warren is an 81-year-old Army veteran of the forgotten war. He is the recipient of the distinguished Synghman Rhee Presidential Unit Citation, Seoul, Korea, 1953.


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Ramblin' Man Tryin' to make a living and doing the best I can
Blogger Bios
Garrison Wells covers El Paso County government and transportation for the Gazette. He is married to Laura, owned by a Lhasa Apso named Lilly, rides motorcycles, plays guitar, holds black belts in jujitsu, karate and weapons and is a published poet. His daughter, Ianthe, lives in Denver. His parents, Al and Miyoko, live in Security.


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I didn't love the art, but I enjoyed the issue.
WonderCon 2015: Malcolm Goodwin - Clive Babineaux in 'iZombie'
We talk about playing the police detective in the show and how he'd react if he was being interviewed by a zombie.
WonderCon 2015: Robert Buckley - Major Lilywhite in 'iZombie'
We talk to the Robert about the show and what he would do if he came face to face with a zombie.
WonderCon 2015: Rose McIver - Liv Moore in 'iZombie'
We talk to Rose about playing a different sort of zombie, the makeup process, and eating brains.
WonderCon 2015: Andrea Romano - Dialogue Director for 'Batman Vs. Robin'
We talk to the Andrea about the movie, casting Weird Al Yancovic as Dollmaker, and her decision to retire soon.
WonderCon 2015: Phil Bourassa - Character Designer for 'Batman Vs. Robin'
We talk to Phil about how he brings the iconic characters to the animated movie.
WonderCon 2015: Sean Maher - Nightwing in 'Batman Vs. Robin'
We talk to the voice of Dick Grayson/Nightwing in the latest DC Universe Original Movie.
WonderCon 2015: Stuart Allan - Damian Wayne in 'Batman Vs. Robin'
We talk to the voice of Damian, the son of Batman, in the latest DC Universe Original Movie.
WonderCon 2015: Jason O'Mara - Batman in 'Batman Vs. Robin'
We talk to the voice of Batman in the latest DC Universe Original Movie.
What's in the Box? Power Up Box Edition
We check out the new monthly box subscription service.
Teen Titans Go! - "Two Bees and a Wasp" Clip
Beast Boy has a new form of currency in exchange for a slice of pizza.
Preview Theatre: ANT-MAN #4
Scott Lang messed up. Find out why his daughter was kidnapped.
Avengers: Rage of Ultron OGN Trailer
What happens after the Avengers believe they've finally defeated the threat of Ultron?
Teen Titans Go! - "Appetite for Disruption" Supercut
Ready, set, fight! There's a whole lot of fighting going on in the next DVD release for the show.
Comic Book 2-Minute Time-Out: Episode 33
There's an all-new, all-different Avengers team coming. Let's attempt to look at what the new roster means.
Teen Titans Go! - "Beast Man" Clip
Beast Boy changes into the unthinkable.
Dan DiDio Unlocks Secrets of CONVERGENCE
Get the lowdown straight from the co-publisher of DC Comics.
Preview Theatre: AVENGERS ULTRON FOREVER #1
The Captain America from the future fights the Golden Skull.
Marvel's Ultimate Spider-Man: Web Warriors - "The Spider-Verse, Part Four" Clip
Spider-Man has to fight the Spider-Goblin. And he's pretty gross looking.
Batman: Arkham Knight Gameplay Video – "Officer Down" Trailer
Batman faces the ultimate threat against the city that he is sworn to protect.
Hands On: Diamond Select Legendary Marvel Super-Heroes Spider-Man Collector Set
We take a close look at the limited edition MEGO-style Spider-Man figure.
Teen Titans Go! - "Truth, Justice and What?" Clip
The truth is revealed as to how the Teen Titans formed.
Hands On: The Joker (Bank Robber Version 2.0) Sixth Scale Figure from Hot Toys
We check out another version of the Joker from Sideshow Collectibles.
Marvel's Ultimate Spider-Man: Web Warriors - "The Spider-Verse, Part Three" Clip
Spider-Man and Spyder-Knight have to fight a mechanical kraken.
LEGO Jurassic World Trailer
Behold the adventure that awaits inside the park.


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Sweet Treasures Home
At Sweet Treasures Home, based in southern California, we pride ourselves on providing top quality French Country furniture and accessories to our customers and now to the online world. We have been offering treasured pieces to our customers for more than ten years. Acquiring vintage finds daily through our travels allows Sweet Treasures Home to offer an ever-changing and fresh twist to the French Country design aesthetic.


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The Nuby Hot Safe Spoons make meal time safe and easy. Features a long easy grip handle to ensure a comfortable, secure hold during feeding and Sure-Temp Sensor safety tip that indicates if food is too hot (110 degrees Fahrenheit or 43 degrees Celsius).
Set includes one blue, orange, pink, and green spoon with fun star and swirl patterns.


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Advanced Flow Engineering, Inc. (AFE) produces high flow, high performance air filters & cold air intake systems for the automotive industry. Founded in April, 1999, AFE was created to address an obvious need in the automotive aftermarket industry: a lack of choice for a high performance aftermarket air filter.
AFE Power - advanced FLOW engineering, Inc. is a manufacturer of high performance cold air intakes, air filters, fluid filters, exhaust systems, intake manifolds, intercoolers, turbochargers, programmers, differential covers, transmission pans and throttle body spacers for late model cars, trucks, SUV's and motorcycles.


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Heart failure. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated October 7, 2013. Accessed October 8, 2013.
How is heart failure treated? National Heart, Lung, and Blood Institute website. Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/hf/treatment.html. Updated January 9, 2012. Accessed October 8, 2013.
Prevention & treatment of heart failure.
American Heart Association website. Available at:
http://www.heart.org/HEARTORG/Conditions/HeartFailure/PreventionTreatmentofHeartFailure/Prevention-Treatment-of-Heart-Failure%5FUCM%5F002048%5FArticle.jsp. Updated March 29, 2013. Accessed October 8, 2013.
This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.
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The Kustom® KG100FX112 is a classic, 100-watt guitar combo amp. It provides two channels (Rhythm and Lead), digital effects and a single 12-inch Kustom speaker.
The KG100FX112 Rhythm channel offers clear, dynamic tones that are perfect for a wide variety of musical styles. Using the Gain control, the Lead channel can dish out anything from chunky Classic Rock sounds to the heaviest, scooped Metal tones out there. Separate Bass, Middle and Treble controls let players fine-tune the tonal response as required.
The KG100FX112 provides built-in Reverb, Delay and Chorus effects that may be activated on the amp's front panel. Reverb can provide anything from subtle room ambiance to an all-out wash of cavernous sound. Delay is perfect for fattening up lead tones, especially when combined with distortion. Chorus adds a shimmering, liquid-like quality to the sound, especially with arpeggiated chords.
Like all KG amps, the KG100FX112 offers an auxiliary input for plugging in an MP3 or CD player to practice along with tunes and a 1/8-inch headphone input. Using headphones, you can silently jam along with recordings, have all of your tone and effects, and not disturb anyone in the process!
An Effects Loop with Send and Return jacks provides flexibility for integrating external effects and processors. A Speaker jack allows the use of external cabinets.
When the KG100FX112 is used with a dual-function footswitch, channel-switching and a "hidden" volume boost feature may be activated. The boost is perfect for making solos stand out in a band mix. (Note: The Kustom KACFS201 footswitch may be used for this application.)
All KG Series amplifiers provide a five-year, transferable electronics warranty to give buyers extra piece of mind with their purchase.


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Situated on the southern approach to Paihia, Heartland Hotel Beachcomber (previously known as the Scenic Circle Beachcomber Hotel) enjoys a premium waterfront location and offers sea views from every room. With a variety of room styles, this is a great place for couples, friends or families to base their visit to the beautiful Bay of Islands.
Your day at Heartland Hotel Beachcomber can start in a number of ways. Relax on your balcony, breath in the sea air and quietly admire the view as the day dawns. If you are the more active type, perhaps you'll start with a quick swim in the beach just below the hotel. Or to fuel up for the day ahead, savour a delicious breakfast and coffee at the Rockpool Restaurant and Bar.
Whatever you have planned, you'll find Heartland Hotel Beachcomber is a comfortable and convenient place to stay. To get into town you can either take a very short drive, or simply wander down a sandy track and around the beachfront.
As our guest you will also enjoy:
• A choice of room styles, sleeping up to five people, and providing good quality room amenities.
• Easy access to local attractions, our helpful staff will be happy to assist with information and bookings for your chosen activities.
• Convenient hotel facilities including Internet access, meeting rooms, guest laundry, and recreational facilities including a pool, spa and tennis court.
View Heartland Hotels in a larger map
The hotel has 45 guest rooms including standard rooms capable of sleeping up to three guests; superior rooms for up to two people; family rooms designed for up to four people and equipped with a kitchenette and microwave and two suites with their own lounge areas. The first, the Puka Suite, sleeps up to five guests while The Pohutakawa Suite sleeps up to four.
All rooms are non-smoking and there are special access rooms available.
All rooms include:
Known as the jewel of the Bay of Islands, Paihia is an ideal base to delve into New Zealand's early history (closeby is Waitangi the scene of the signing of the treaty between Maori chiefs and the British crown in 1884), experience Maori culture, explore the countryside or avail yourself of the many water activities in this water bound paradise. Just some of the many attractions include:
Like the rest of the hotel the Rockpool Restaurant & Bar overlooks the stunning waters of the Bay of Islands, offering stunning panoramas across the Bay and through to Opua and Russell.
Enjoy breakfast here from 6.30am until 9.30am and evening a la carte dining from 6pm until 9pm. The Rockpool Bar is open from 4.30pm, so come and take in the view.
Our chef delights in making use of local foods so look out for dishes like the Bay of Islands mussel and fresh dill chowder, kumara frittata made with Northland sweet potato and locally caught fish fresh off the boats.


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Thursday, October 25, 2012
In the spirit of the holidays, Dr. Beth Alberto and Dr. Chuck Whitfield, audiologists at Hearing Care of Summerville, want to provide a pair of digital hearing instruments for a deserving individual who otherwise might not be able to acquire them.
The holidays are a time of connecting with others, says Dr. Beth We want to help someone enjoy all of the sounds of the season without worrying about still trying to make ends meet.
Hearing Care of Summerville will accept essays of 500 words or less that describe how an individual deserves and would benefit from new hearing instruments. Nominations will be judged by an independent panel based on the following criteria: degree of hearing loss, how the individual has overcome hearing loss, financial need and inability to acquire quality instruments, and how winning new instruments would impact his/her life. Submissions should be mailed to Hearing Care of Summerville, 208A East 2nd North Street, Summerville SC 29483 and must be postmarked by Oct. 31. Nominees may be asked to provide a recent audiogram. The winner will be announced during the practices Patient Appreciation Day celebration on Nov. 15.
Hearing Care of Summerville is committed to providing quality, compassionate hearing healthcare for all ages, from infancy to adulthood. Beth Alberto and Chuck Whitfield, our Doctors of Audiology, employ the latest technology and information to educate and engage each individual patient to select the best hearing solution to fit their needs and budget. For more information, contact Lolli Haugh at 843-871-9669.
The Journal Scene is pleased to offer readers the enhanced ability to comment on stories. We expect our readers to engage in lively, yet civil discourse. We do not edit user submitted statements and we cannot promise that readers will not occasionally find offensive or inaccurate comments posted in the comments area. Responsibility for the statements posted lies with the person submitting the comment, not The Journal Scene.
If you find a comment that is objectionable, please click "report abuse" and we will review it for possible removal. Please be reminded, however, that in accordance with our Terms of Use and federal law, we are under no obligation to remove any third party comments posted on our website. Read our full terms and conditions.
© 2015 The Journal Scene an Evening Post Industries company. All Rights Reserved.
Registration on or use of this site constitutes acceptance of our Terms of Service, Privacy Policy and Parental Consent Form.


text: Just went to Target this morning around 8:30 and there were only about ten other customers in the store. The sales were still going on, and the employees were calmly restocking the shelves. It was a great time to shop. I think Black Friday strikes a primitive urge in some people. Competition for the (supposedly) scarce resources, the adrenaline rush from scoring a deal, the excitement of being part of a herd (or pack, I should say, as in wolves.) Let's face it: Most people lead pretty mundane, sendentary lives. Black Friday provides an acceptable way for these folks to display behavior a couple of rungs down on the evolutionary ladder!


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|421 posts found
Ok. So I noticed some people are hating on me liking WoW's raiding system and trinity. You guys are constantly saying how easy WoW dungeons are (and you noticably do not raid current content). Dungeons are SUPPOSED to be easy. They are for entry level players looking for entry level loot so they can feel a sense of accomplishment. Then, there is raiding, heroic raiding, and for the truly brave, the new challenge mode dungeons, which I have completed all on gold with a TON of dedication and effort. If you think getting gold challenge modes is easy, then you are simply lying. You have to play your defined role to absolute perfection, and there is no bigger rush in MMOs today!
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As an addendum, WoW gives you many different types and difficulties of PvE content, whereas GW2 just has a really easy cluster**** version and a more difficult cluster**** version.
You find WoW dungeons easy because that is the content you are choosing to do. Super easy mindnumbing stuff. Raid or do challenge modes, and trust me, you will NOT be bored. You will need to tweak your abilities in your defined role to the best they can be to down some of the most difficult content (heroic raid bosses and CM golds).
Elite Member
Joined: 9/19/06
Originally posted by Vaelgard
That honestly sounds like fun. I should have checked in on those challenge modes while I was playing as they did look interesting to me. I used to do heroic raiding in Lich King. And yeah, it was difficult for us.
But I don't think any of that is dependant on the holy trinity. I agree that you can have challenging content in both situations, but the predictability level in a holy trinity game is much higher in my opinion. Maybe that's the difference. In one scenario you are reacting a lot more (no trinity) and in another you are mostly working on perfecting the movements and timing of the encounter (trinity).
In other words, it's more of a taste thing.
SWTOR is the greatest mmo ever!
Originally posted by colddog04
You make a good point, and yes, ultimately, everything is a matter of taste. What I didn't mention about the challenge modes, however, is how much you have to stretch your role and almost encompass other roles of the trinity in order to succeed in getting gold medals. For example, a tank has to run into the next room and pull all of the mobs while the healer is drinking. The tank needs to use his defensive CDs and self heals and the dps have to pull off certain mobs or DPS down things in order for the tank not to die. The object is survival until the healer can enter the room and continue the fight. I know the roles are still basically the roles, but it offers a really nice amount of dynamic feel to the holy trinity.
Elite Member
Joined: 9/19/06
Originally posted by Vaelgard
I'm going to roll back over once the new arena season is announced and I'll check those out. They sound fun.
SWTOR is the greatest mmo ever!
Spotlight Poster
Joined: 3/06/12
I liked "trinity" more. I like having roles like dps, healer or tank.
Website: http://www.emrendil.com
Novice Member
Joined: 5/27/05
In evry mmo i played i always been a healer.
Just love that role.
Not interested in being a rambo with a first aid kit strapped behind my back that shoot mage lazers trough my eyeballs while wielding tank shields on both my arms. =P
Novice Member
Joined: 11/02/10
game is also real
I think dual skill like war/monk or any other form of healer as dual class would be my best choice.
GW2 system is more enjoyable to be as I'm not dependent on healer for lvl up, solo progress.
I think role of tank is obsolete in game where anybody can heal.
I don't see hybrid class in sense of 50:50 skill equal; I would prefer like 10 primary and 2-3 healer skills with 1 AoE heal but long cd.
I like live in a party but sometime it can be hard to find it so why not to do solo run?
As for dungeons, where trio was most needed, it may works too if we can heal each other.
try before buy, even if it's a game to avoid bad surprises.
Elite Member
Joined: 1/06/05
Originally posted by Quirhid
did you not have roles?
1, All I know was that in our campaigns the fighers were out front. The fighers were the members who were taking the damage, blocking, throwing themselves into the fray,
2, We actually did have firing into the area where melee was if it was necessary or if melee was blocking a path and the ranged could fire over their heads.
3, we had ranged healing. Sorry but we changed the rules to suit our needs. So having said that I suppose one's mileage may vary.
The D&D I knew was closer to the trinity.
Novice Member
Joined: 1/13/08
My problem with the trinity mainly comes down to the fact that, a lot of the time, a smart group who isn't the trinity can't accomplish the same feats as a group who isn't as intelligent with their gameplay descisions, but is using a trinity. If all of my friends and I want to try and do content as barbarians, It should be POSSIBLE for us to complete the content. I'm not saying it should be as easy as a Priest/Paladin/Sorcerer mixed group, but it should be possible. I like to think that a smart group of Warriors should be capable of taking down a raid boss.
I play MMOs for the Forum PVP
Originally posted by Sovrath
I really think people are starting to mix up D&D they played on the computer and tabletop D&D.
It is true that D&D characters had roles but they weren't the trinity you see in MMOs.
1. Fighters were considered tanks, yes but they also dished out a ton of damage. And they didn't taunt or hold agro, they blocked the way with their bodies. I also recall having clerics in the frontlines also since their armor and spells gave them potentially better AC than fighters.
2. You could fire arrows past your fighters just like the mobs could fire past them. But yeah, forget about tossing a fireball that does AoE damage or chain lightning.
3. In tabletop, you rarely healed during battle. It was used when things got desperate. Heals were normally done after the battle was won because healing took away precious attacks. Buffs and debuffs were much more prevalent. Computer games incorporated healing so much more because you could reset heal spells with resting. It was just a press of a button; not so in tabletop.
Advanced Member
Joined: 5/28/06
I don't want the trinity back at all.
Apprentice Member
Joined: 7/09/12
Get rid of the trinity and then you may as well get rid of classes, and make every player a cookie cutter of each other. No don't get rid of the trinity concept.
OK, ok ..a better design I've seen was to make every player identical at first, but then let them choose where they would like to specialize in. Eve has this. Other games have the idea to some extent, even if you choose a set role, allow for change over time.
Allow players to specialize in areas they want. In typical warfare these days, there are soldiers, artilliary / range attacks, medics, and members of the clergy (various denominations). I think the trinity is practical, but as you develop a character, a player might decide for a change.
Get rid of healers?
Clergy members work best in fantasy, because priests can essentially pray for actions. If anything, modern MMORPGS abuse the role of priests, because when a priest gets a prayer answered in pen-and-paper games it is significant (and requires a lot of praying). Not some minor autocast spell in MMORPGS. Having a priest is essential in PnP.
If anything, I'd see an argument against the trinity in Sci-Fi games. Heal mortal wounds with fix-em droids .. are you serious?
Want a nice understanding of life? Try Spirit Science: "The Human History"
Elite Member
Joined: 1/06/05
Originally posted by SpectralHunter
You are very correct. But quite frankly that's how mmo's should be. Warriors should be dishing out damage and AOE spells were never fired into the fray. That's just common senes. Clerics were in the front but I don't remember them being killer Damage dealers.
The idea being that in D&D players had roles. Mages didn't march into the battle and Thieves/Rogues were always trying to get the upper hand in a sneaky way.
I don't think anyone, myself included, would say that mmo's and table top have a 1 to 1 correlation as to how accurate their rules transfer.
But the idea is that in D&D we had roles, and roles that each of us wanted to embody. I think when people are asking "do you want to have the holy trinity back, what they are saying is they want to embody those roles. If anyone can be in front, if anyone can be healing, if anyone wield magic then things stop becoming unique.
Originally posted by SovrathOriginally posted by SpectralHunter
you can be more unique without set roles..just depends how the system is implemented.. In most holy trinity games I feel the exact same as the next guy of my class.. If the system allows me to essentially make my own class I feel much more unique
I angered the clerk in a clothing shop today. She asked me what size I was and I said actual, because I am not to scale. I like vending machines 'cause snacks are better when they fall. If I buy a candy bar at a store, oftentimes, I will drop it... so that it achieves its maximum flavor potential. --Mitch Hedberg
Originally posted by Sovrath
Just copying the paragraph that I wanted to discuss. I agree with everything else you said in reply.
Are you sure that's what the proponents of the trinity system wants? I get the impression they want just three roles: tank, healer, dps and once you are locked into a role you cannot deviate from it. They want the tank to hold agro while the healer heals to keep him alive and have the dps rain damage upon the mob. The trinity is three roles and once you pick a class you are that role.
I personally like the hybrid system better but with roles that fluctuate and change depending upon the encounter.
Fighters in tabletop could do lots of damage...pretty much everyone could (clerics with buffs hit hard and they had offensive spells). They also resisted certain types of damage, so much so that in some cases, they didn't need much support. But against magic they were very vulnerable. In fact, mages were better equipped in handling mobs with magic. Rogues also. Every class had their unique ability to tank and dps depending upon the encounter.
I guess that's what I want. Currently, the tank is always the warrior in MMOs. It doesn't matter if the mob is completely magical and could/should devastate a warrior. How much more interesting would it be if the mage had to "tank" the mob by casting spells and counterspelling while the warrior attacked when vulnerabilities opened up?
Hard Core Member
Joined: 2/14/11
Originally posted by Zzad
also seems pretty common practice people get very complacent in certain things and when something new comes along instead of trying to learn it they cry they want what they know back.. Me personally I get bored with same old same old all the time and happy to learn something new..
I angered the clerk in a clothing shop today. She asked me what size I was and I said actual, because I am not to scale. I like vending machines 'cause snacks are better when they fall. If I buy a candy bar at a store, oftentimes, I will drop it... so that it achieves its maximum flavor potential. --Mitch Hedberg
Originally posted by Aerowyn
People hate change, even if it's an improvement.
Originally posted by SpectralHunterOriginally posted by Aerowyn
haha so I have noticed.. I don't really get why though.. More variety the better I always say
I angered the clerk in a clothing shop today. She asked me what size I was and I said actual, because I am not to scale. I like vending machines 'cause snacks are better when they fall. If I buy a candy bar at a store, oftentimes, I will drop it... so that it achieves its maximum flavor potential. --Mitch Hedberg


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Thursday, April 4, 2013
Late last year, Middleton Place welcomed the crew from the locally-produced, nationally televised show Army Wives to the National Historic Landmark to film a scene critical to the drama of the show's 7th season. Working closely in concert, Middleton Place and Army Wives personnel worked out a carefully conceived filming location: at the footbridge over the Mill Pond.
The utmost care and concern was given to the landscaping by the film crew, and no part of the property was damaged. This was no small feat. After prepping the site for power, parking, and catering the day before, about 125 cast and crew members arrived the morning of December 18 for the day's shoot. Several tractor-trailers of electronics and equipment were parked on the Greensward, along with more than 100 automobiles. The crew built a plywood pad from the access path on the south side of the House Museum that ran around the Plantation Chapel/Spring House down the hill to the bridge. The padding was necessary to accommodate an 8,000-pound camera crane, which was eased into place for multiple shots.
Although Middleton Place staff agreed not to tip off viewers about the scene's subject matter, it does involve most of the principal actors on the show in a very dramatic moment, and Middleton Place is featured prominently, and mentioned in the script by name. Middleton Place is already easily visible in the trailers for the upcoming episode.
Although the episode containing the scene filmed at Middleton Place aired March 17 on the Lifetime Channel, it can be caught in reruns throughout the season or can be viewed for free at the Army Wives website: www.mylifetime.com/shows/army-wives.
The Journal Scene is pleased to offer readers the enhanced ability to comment on stories. We expect our readers to engage in lively, yet civil discourse. We do not edit user submitted statements and we cannot promise that readers will not occasionally find offensive or inaccurate comments posted in the comments area. Responsibility for the statements posted lies with the person submitting the comment, not The Journal Scene.
If you find a comment that is objectionable, please click "report abuse" and we will review it for possible removal. Please be reminded, however, that in accordance with our Terms of Use and federal law, we are under no obligation to remove any third party comments posted on our website. Read our full terms and conditions.
© 2015 The Journal Scene an Evening Post Industries company. All Rights Reserved.
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Ao Nang : Fast Food
Many of the multinational fast food chain restaurants have adapted their menus to attract the local consumer. You might be surprised to find items like a Pork Samurai burger or pizzas topped with tuna fish and corn.
By Thai standards fast food restaurants are considered expensive and eating at these places are considered a special treat. Several of the larger chains offer home delivery.


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November 11, 2008
Google Pack, a Reward for Google's Partners?
When Google launched Google Pack in January 2006, Larry Page said that software companies don't have to pay Google to be included in the bundle. In addition to including most of its software, Google added an anti-virus and an anti-spyware software from Symantec, Firefox with Google Toolbar (Google and Mozilla have a search deal), Adobe Reader (Google and Adobe have a distribution deal), Skype (eBay and Google have an ad deal), RealPlayer (Google and RealNetworks have distribution deals), StarOffice (Sun and Google had a distribution agreement).
"Every program included in the Google Pack is free, has earned a reputation for excellence, and was evaluated to ensure it meets Google's Software Principles. Google respects users' rights to control their own computers and does not include software that is spyware, generates pop-ups, or that is difficult to uninstall," mentioned Google in a press release.
After removing Trillian and Ad-Aware, last week Google removed StarOffice from Google Pack and one of the possible explanations is that Sun signed an agreement with Microsoft to bundle MSN Toolbar with Java downloads. "With the vast array of Java software-based Web applications that are downloaded every month, this deal will expose Live Search to millions more Internet users and drive increased volume for our search advertisers," said Yusuf Mehdi from Microsoft.
A Google representative told eWeek: "We are constantly evaluating which products to include in Google Pack to make it more valuable to users. At this time the agreement to distribute StarOffice through Google Pack has expired, and we have decided with Sun not to renew the agreement."
If Google wants to offer a valuable software package for its users, maybe it's time to stop including software just because it's developed by partners. There are plenty of better alternatives to Norton Anti-Virus, RealPlayer, StarOffice and some of them are free or even open-source.
This blog is not affiliated with Google.


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Wind: 0 mph
Once upon a time, long ago in a faraway place, there lived a young boy who would be king. He wanted for nothing and life was good except for one problem. Ramses II suffered terribly from toothaches.
Three thousand years later, 21st-century CAT scans of his mummy reveal that he died in his 20s with multiple, septic, intrabony abscesses, and quite possibly from them, too. Microbes have been around a long time and are very good at what they do. They can be formidable and deadly enemies or life-saving allies, as entertained by H. G. Wells over 100 years ago in War of The Worlds. Enabling us to peer into the past without changing or destroying the present, computer tomography is our modern-day time machine …well, sort of.
Both of these individuals were in their 30s when they died. In the left X-ray is evidence of periodontal disease and severe occlusal wear because a significant ingredient in his diet was sand. Herbivores use other mechanisms to compensate for attrition. We're not so lucky. The right image reveals four infections within the bone; and that's just in one quadrant. Radiographs of other mummies reveal evidence of primitive and unsuccessful attempts at root canal treatments. They were desperate to try anything.
Dental disease has been the scourge of our species since before recorded history. Skulls of Neanderthal and Cro-Magnon's dentition don't show caries … probably because that was long before refined carbohydrates and donuts. They do, however, exhibit severe wear from masticating abrasive foods.
Tooth decay and periodontal disease are in the top two positions on the hit list of afflictions that torment our species. They are not confined by ethnic, religious, gender, racial, or socioeconomic boundaries. It used to be that they were merely painful inconveniences with occasionally known serious consequences. "You're born without teeth, die without 'em, and they're just a pain in the neck in between. Not so. One's teeth should, would and could last a lifetime.
Recent evidence-based analyses reveals a pathogenic oral-systemic link between chronic inflammatory disease and systemic diseases. The American Heart Association, the American Medical Association, the American Diabetes Association and other well-respected organizations have proven a causal/effect relationship between chronic inflammation and heart disease, diabetes, stroke, arthritis, birth defects, nephritis and pancreatic cancer. I'm sure others will follow. We now know why good oral health is so important. In other words, one cannot possibly be in good general health without healthy teeth and gums.
Adequate nutrition is essential for good health, so being able to chew proper foods is very important for our well-being. Fortunately, that revelation has coincided with an extraordinary advance in dental technology. For the first time in the course of human history, we are able to replace lost and missing teeth one at a time. It's not necessary to wrestle with partial dentures or sacrifice adjacent healthy teeth as bridge abutments. Edentulous patients no longer have to cope with the annoyance, inconvenience, embarrassment and discomfort of removable dentures. They now have the option of fixed prosthetic replacements. While it's still a drag getting sick, there's been no better time to replace worn out or lost body parts.
It's mostly the young and old who have to dodge the caries bullet, while the middle-aged and elderly have to battle root caries and periodontal disease. The bad news for all of us that it's a lifetime struggle. The good news: Both can be easily and inexpensively prevented with a minimum of time, effort and cost.
By the time you've read this, it will have been past your morning routine, but in time for this evening's. Will you remember?
Zonies is a dentist and he lives in Fayston.


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Corporate and Community Services Homepage
Kent State University at Ashtabula takes pride in being an integral part of the Ashtabula area community. We value the relationships that we have developed with local corporations and community organizations.
Our campus offers a variety of services to organizations and individuals in our community, including customized training, continuing education and professional development programs. If you are interested in learning more about these programs, please contact Lori Lee at (440) 964-4309.


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Mini Appetizer Spoons, Set of 8 2 2
Great presentation! I bought 8 sets of these spoons in order to serve one-bit appetizers for one of the appetizer dishes I was making for a baby shower for over 50 guests. These are not typical Asian soup spoons; these are meant for appetizers and bite-size desserts, so they were perfect for my needs! I love them and I know I will use them again and again, no matter what the size of the party! September 3, 2013
Beautiful but really small I was expecting spoons to be a little bigger. They are very nice, but small. July 16, 2013
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Parents & Family Weekend 2015
Parents and Family Weekend banner
2015 Parents & Family Weekend - February 20 - 22
Saturday, February 21, 2015
The Monte Carlo event scheduled for this evening in the Student Union Apollo Room is ON!
The Sunday Breakfast will be held as scheduled tomorrow, Sunday, February 22nd, in the Nutter Center Berry Room.
Please call (937) 775-2727 or (937) 260-0167 with any questions.
This is one weekend you do not want to miss! Join your student on campus for some warm family fun: Raider Basketball, Pre-Game Party, Monte Carlo Night, Live Band Karaoke, Breakfast with President Hopkins, and more.
Check-in begins Friday, February 20, 5-7:30 p.m.
in the Student Union Atrium
Featured Events
Featured Events
- Monte Carlo Night
- Wright State Women's Basketball Game vs. Oakland
- Parents & Family Weekend Sunday Breakfast
Parent of the Year Award
Parent of the Year Award
The Office of Student Support Services is now taking nominations for Wright State University Parent of the Year.


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DALLAS (December 21, 2012)--Southlake Carroll quarterback Kenny Hill joins Johnny Manziel on a short list of Texas high school football stars and he plans on joining the Heisman Trophy winner at Texas A&M next year, too.
Hill was named the Texas Associated Press Sports Editors player of the year Friday after leading Carroll on another long playoff run a year after winning a Class 5A championship.
Manziel was the AP player of the year in 2010 at Kerrville Tivy.
A panel of sports writers and editors who cover high school football in Texas chose Hill, who has orally committed to the Aggies.
The son of former major league pitcher Ken Hill threw for 2,291 yards and 20 touchdowns during the regular season.
He had 905 yards rushing and 20 more scores.
Winners Of The Texas Associated Press Sports Editors Player Of The Year Award
2012: Kenny Hill, QB, Southlake Carroll
2011: Johnathan Gray, RB, Aledo
2010: Johnny Manziel, QB, Kerrville Tivy
2009: Scotty Young, QB, Denton Ryan
2008: Garrett Gilbert, QB, Lake Travis
2007: Jacquizz Rodgers, RB, Rosenberg Lamar


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The Beautiful Cover
By nancy
from Granite City,Il
About Me Collector
Best Uses
Comments about America the Beautiful Collectors Quarter Map:
I this good of all ages and will be fun to look for the different ones.
Bottom LineYes, I would recommend this to a friend
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(1 of 1 customers found this review helpful)
Too Bad
By Gadget Shopper
from Las Vegas, NV
Bought this for my father; he collects coins. The cut-outs are too small and don't hold the quarters; they fall out all the time. I didn't know until it was too late to return it. Plus, good luck finding any of these quarters in circulation to collect!
Bottom LineNo, I would not recommend this to a friend


text:
OAKLAND, CA - Hiroki Kuroda gave up just four hits in eight innings Sunday and the New York Yankees shut out the Oakland Athletics, 2-0, to finish off a three-game sweep.
Kuroda (4-6) snapped a two-start losing streak, striking out three and walking one while throwing 67 of his 104 pitches for strikes.
The 37-year-old righty wasn't given the chance to pick up his first shutout in almost four years. Rafael Soriano worked around a Josh Reddick single for his fifth save of the season.
Andruw Jones belted a leadoff homer in the second inning for the only run the Yankees needed for their fifth straight win.
Derek Jeter led off the game with a single to pass George Brett for 14th place on the all-time hits list with 3,155.
The A's dropped five in a row to finish 1-5 on a six-game homestand and were swept for the first time this season. Tommy Milone (6-4) took the loss in 6 2/3 innings, giving up two runs on eight hits and two walks.
The Yankees got nothing out of a bases-loaded situation in the first inning, but took the lead on Jones' first-pitch homer to left-center field leading off the second.
It remained 1-0 until Curtis Granderson singled to start a two-out rally in the seventh inning, coming home on Mark Teixeira's double to the right-center field gap.
Ryan Cook came in for Milone after that and got Alex Rodriguez on a grounder to end the inning, but the A's couldn't muster any runs. They ended 0-for-3 with runners in scoring position and stranded four runners.
Game Notes
Jones hit his fifth homer of the season...Kuroda's only two shutouts came in 2008 with the Dodgers: on June 6 over the Cubs and July 7 against the Braves, when he carried a perfect game into the eighth inning...The Yankees' winning streak comes on the heels of a 1-6 stretch. They will continue their nine-game road trip with the first of three in a row against the Angels in Anaheim on Monday...Cal Ripken Jr. is 13th on the all-time list with 3,184 hits...The A's will start a six-game road trip Monday against the Minnesota Twins.


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Big dollars target roads and bridgesBy JOSH OGORMAN
VERMONT PRESS BUREAU | June 03,2014The largest transportation budget in the states history will fund paving and bridge repair, as well as improvements for air and rail travel.
Gov. Peter Shumlin signed a $685.7 million transportation budget for the upcoming fiscal year Monday morning, with goals to pave nearly 400 miles of road and repair or replace more than 100 bridges.
This budget makes sound investments in our infrastructure that will grow Vermonts economy not only by directly creating jobs in the construction industry, but also by supporting other important economic sectors, such as tourism, agriculture, hospitality, manufacturing, among others, Shumlin said.
The budget represents an increase of 5 percent, or $32 million, compared to the FY 2014 budget of $653 million, and will fund more than 800 projects around the state.
Several successive years of record-level investment are yielding positive results, said Brian Searles, secretary of the Agency of Transportation. We are seeing improved performance in pavement quality and in the condition of our structures. To continue these gains, this transportation bill will advance the repair or replacement of more than 100 bridges, perform preventive maintenance on dozens of structures and improve more than 375 miles of pavement.
At $140.3 million an increase of $7.6 million, or 6 percent compared to the current budget bridge replacement and repair makes up approximately 20 percent of the overall budget. Searles said much of the work will include replacing the temporary bridges that were erected following flooding from Tropical Storm Irene in 2011.
There are still expenditures related to Tropical Storm Irene and other weather events to the tune of $50 million, Searles said.
The budget includes approximately $19 million from the Federal Emergency Management Agency. Searles said he expects Irene repairs to be completed by the end of the 2016 construction season.
The budget also includes $115.7 million for paving, an increase of $7.5 million, or 7 percent, compared to the current budget. Plans include paving 95 miles of interstate highways and 210 miles of state roadways.
On the local level, the budget includes $4.3 million for paving and improvements on Route 4 and Route 7 in Rutland; $2.5 million for Route 3 between Proctor and Rutland, and $1.6 million for Route 100 in Killington.
Also on deck is $500,000 in repairs to Route 302 in Berlin, which connects Barre and Montpelier; $2 million to repair the Route 14 bridge in East Montpelier; and $1 million for a shared-use path between Berlin and Montpelier.
In the Rutland area, public transportation dollars will fund improvements for air and rail travel. The Rutland regional airport will receive approximately $7 million in federal money due to a mandate from the Federal Aviation Administration to improve a safety area around the runway.
Also, the long-in-the-works Western Rail Corridor project will receive $19 million to upgrade an additional 10 miles of tracks and build a bridge in Pittsford. When work is complete, there will only be an additional 12 miles of track improvement needed before the corridor can open up and allow Amtraks Ethan Allen Express to travel between Rutland and Burlington.
Searles said that if the state receives another federal rail grant in 2015, travel could begin as early as the end of 2015.
email@example.com IN Vermont NewsBURLINGTON The Vermont Health Department has put out a warning about the wild parsnip, a common... Full StoryBELLOWS FALLS A Vermont restaurant is applying to the Guinness Book of World Records after... Full StoryMONTPELIER This weekend will mark the official unveiling of the Lost Shul, an Eastern... Full Story
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- RICHARD'S POOR ALMANACK: On this day 1739, 'Richard Palmer' identified in prison at York Castle as the notorious outlaw DICK TURPIN; IN 1836, Battle of the Alamo begins near San Antonio de Bexar, Texas; 1896, the Tootsie Roll invented by LEO HIRSCHFELD.
- RICHARD'S POOR ALMANACK: On this day in 1472, Orkney, Shetland islands put up as collateral by Norway to Scotland in lieu of dowry for MARGARET OF DENMARK on her marriage with JAMES III, king of Scotland; 1962, JOHN GLENN first American to orbit Earth.
- TOMORROW'S HEADLINES TODAY: City mayoral candidates debate campaign issues; Hartford, Conn., woman still missing; Neal Goswami reports attempts to legislate suicide; local woman loses 100 pounds through TOPS program.
- RICHARD'S POOR ALMANACK: On this day in 1878, JOHN TUNSTALL murdered near Lincoln, New Mexico, by the outlaw JESSE EVANS; in 1930, ELM FARM OLLIE first cow to fly in aircraft, first to be milked airborne; 1955, nuke test WASP; '79, snow in Sahara.
- TOMORROW'S HEADLINES TODAY: Rutland Herald News Editor Alan J. Keays and staff writer Gordon Dritschilo discuss stories planned for the February 18, 2015, edition of the newspaper: Winter budgets maxed, legal marijuana, Springfield bank job, USPS slowdown
- RICHARD'S POOR ALMANACK: On this day in 1249 AD, ANDRE of LONGJUMEAU is dispatched by LOUIS IX of France to meet the KHAGAN, ruler of the Mongol Empire; in 1804, during 1st Barbary War, STEPHEN DECATUR scuttles the pirate-held USS Philadelphia in Tripoli.


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Learn to develop HDR photos with Photomatix.
Photographer Ben Long describes and demonstrates high dynamic range (HDR) photography, a technique that broadens the luminance or range between the lightest and darkest areas of an image.
"lynda.com has enabled me to grow my skill set at an affordable price. I find the business profiles/documentaries inspiring and the training is top notch." —Shawn C.
more from our members »


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- Welcome to the 2014/15 season
- Season Calendar
- New Productions 2014/2015
- New Productions 2015/2016
- Revivals 2014/2015
- Revivals 2015/2016
- Recitals 2014/2015
- Recitals 2015/2016
- Concerts 2014/2015
- Concerts 2015/2016
- NOW! Opera for you / Events for children and young people 2014/2015
NOW! Opera for You 2015/2016
events for children
and young people
- Special Events 2014/2015
- Special Events 2015/2016
- Cast Changes
- Ensemble, guest artists and the Opera Team
- The orchestra
- Opera Studio
- Videos
- Press Releases
Pier Giorgio Morandi
Pier Giorgio Morandi is First Guest Conductor of the Helsingborg Symphony Orchestra. After time spent studying with Leonard Bernstein and Seiji Ozawa and assisting Riccardo Muti and Giuseppe Patané at La Scala Milan, he became Chief Conductor of the Teatro dell'Opera in Rome in 1989. He also held the post of First Guest Conductor of the Hungarian State Opera in Budapest and the Royal Opera in Stockholm. Recent productions have included Madame Butterfly in Oslo and Dresden and Macbeth, Don Carlo, Aida and Lucia di Lammermoor at La Scala Milan. Roles at Oper Frankfurt in recent seasons were Tosca, Madame Butterfly, Boito's Mefistofele, Verdi's Macbeth, La Traviata, Norma (in concert), Simon Boccanegra and, in 2012, Maria Stuarda (in concert). In will return to Frankfurt in 2014/15 and 2015/16. Other engagements included appearances at the Vienna State Opera, Zurich Opera, the Deutsche Oper in Berlin and the Arena di Verona. Future projects include Tosca in Göteborg, Turandot in Dresden, Otello in Beijing and Manon Lescaut in Tokyo.
Saison 2014/2015
Giuseppe Verdi


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|A companion catalog to YIVO's newest exhibition, Stars, Strikes, and the Yiddish Stage: The Story of the Hebrew Actors' Union, 1899–2005, is now available. A major gift from Eli Broad, businessman and noted philanthropist, made the preservation of the records of the Hebrew Actors' Union and this exhibition possible. The catalog includes a lively scholarly essay about the union and the Yiddish theater by Edna Nahshon along with posters, programs, correspondence, and other records of the HAU's rich history.
|Copies of the catalog may be purchased for $15.00 at the Fanya Gottesfeld Heller Book Store (917-606-8220)
YIVO members receive a 10 percent discount
| The exhibition is now on view in the newly renamed Eli and Edythe Broad Foundation Gallery in Honor of Leon and Rebecca Broad
Mezzanine Level
YIVO Institute at the Center for Jewish History
15 West 16th Street - NYC view map
For directions and parking information, click HERE


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News from the world of Maths
November 4, 2011
Have you ever wondered what string theory sounds and looks like? If yes, you can find out this weekend at Queen Mary, University of London. Musicians Anna Piva and Edward George, in collaboration with physicist and Plus author David Berman and mathematical physicist James Sparks are developing Explorations in Eleven Dimensions, a multimedia art project based on a series of sonic, visual, and textual readings of string theory's equations, themes and aesthetic concerns.
October 24, 2011
Whenever you smell the lovely smell of fresh coffee or drop a tea bag into hot water you're benefiting from diffusion: the fact that particles moving at random under the influence of thermal energy spread themselves around. It's this process that wafts coffee particles towards your nose and allows the tea to spread around the water. Diffusion underlies a huge number of processes and it has been studied intensively for over 150 years. Yet it wasn't until very recently that one of the most important assumptions of the underlying theory was confirmed in an experiment.
October 21, 2011
It's 21st of October and for puzzle lovers this can only mean one thing: the G4G Celebration of mind. This annual party celebrates the legacy of Martin Gardner, magician, writer and father of recreational maths, with mathemagical events in his honour happening all over the world.
October 13, 2011
In 1982 Dan Shechtman discovered a crystal that would revolutionise chemistry. He has just been awarded the 2011 Nobel Prize in Chemistry for his discovery — but has the Nobel committee missed out a chance to honour a mathematician for his role in this revolution as well?
October 11, 2011
October 11, 2011
With Euorpean governments struggling to avert imminent disaster in the Euro zone, the award of this year's Nobel Memorial Prize in Economic Sciences could not be more relevant. The prize has gone to Thomas Sargent and Christopher Sims whose work explores how and if policy decisions can affect the economy and how unexpected shocks spread through it.
October 11, 2011
Next year sees the centenary of Alan Turing's birth. To celebrate, the Mathscareers website is running a competition for 17 to 19 year-olds. Your task is to write an article on Turing's work and the prize is £100 Amazon voucher and having your article published on the website. See the Mathscareers website for more details.
October 7, 2011
Today is Ada Lovelace Day celebrating the work of women in mathematics, science, technology and engineering. Since Plus is run entirely by women, we're very happy to join in! We've got plenty of articles and podcast by or about women mathematicians, so we've put together a selection of favourites.


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Bring a large pot of salted water to a boil. Drop hearty greens into water and blanch for 4 minutes. Immediately plunge blanched greens into a bowl of ice-cold water to stop the cooking. Drain, squeeze dry, and set aside.
Heat oil and garlic in a large skillet over medium-low heat. Cook until the garlic is golden around the edges, 8 to 10 minutes. With a slotted spoon, remove garlic from skillet; set aside.
Raise heat to high. Add hearty greens and cook for an additional 5 minutes. Add spinach; season with salt and red pepper flakes to taste. Cook until spinach wilts, stirring frequently (about a minute). Return garlic to pan and stir. The greens can be served immediately or at room temperature.
Blanching does not actually cook the greens but softens their texture, while shocking them in cold water keeps their color strong and vibrant.


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Higher Education Act Information01. Notice of Availability of Institutional and Financial Aid
Financial Aid Information
Institutional Information (FERPA)
02. Contact Information for Assistance in Obtaining Institutional or
Financial Aid Information
Financial Aid Contact Information
Institutional Contact Information (FERPA)
03. Student Financial Aid Information
04. Notice of Federal Student Financial Aid Penalties for Drug Law Violations
05. Privacy of Student Records--Family Educational Rights and Privacy Act (FERPA)
06. Consumer Information on College Navigator Website
07. Facilities and Services Available to Students with Disabilities
11. Refund Policy, Requirements for Withdrawal and Return of
Title IV Financial Aid
Refund Policy
Requirements for Withdrawal
Requirements for Return of Title IV Financial Aid
12. Textbook Information--Will be available beginning summer
13. Academic Program Information
Current Degree Programs
Instructional and Laboratory Facilities
Faculty and other Instructional Personnel
Plans for Improving the Academic Program
14. Transfer of Credit Policies
Articulation Agreements--USG Institutions
Articulation Agreements--TCSG Institutions
15. Institutional and Program Accreditation, Approval, or Licensure
Accreditation Reports
16. Copyright Infringement Policies and Sanctions
17. Teacher Preparation Program
18. Drug and Alcohol Abuse Prevention Program
20. Security Report, Timely Warnings and Crime Log
21. Security Report--Missing Person Notification Policy--Will be available beginning September 2010.
22. Fire Safety Report and Fire Logs----Will be available beginning September 2010.
23. Information for Crime Victims about Disciplinary Proceedings
24. Retention Rate
25. Completion/Graduation and Transfer-out Rates
26. Completion/Graduation and Transfer-out Rates for Students Receiving Athletically-Related Student Aid
29. Types of Graduate and Professional Education in which the
Institution's Graduates Enrolled
30. Intercollegiate Athletic Program Participation Rates and
Financial Support Data


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The always surprising video sharing service acquired by Google in October 2006 is constantly improving its search features and borrows many tricks from its parent company. The latest enhancement is an auto-complete feature that shows query suggestions as you start typing characters in the search box. You'll notice the obvious similarity between this feature and Google Suggest, a project that is about to finally graduate from Google Labs. YouTube Suggest has its own list of queries obtained from YouTube users, so it should offer decent suggestions.
"By suggesting more refined searches up front, Google Suggest can make your searches more convenient and efficient by keeping you from having to reformulate your query. Google Suggest might offer suggestions that you will find novel or intriguing," explains Google in an interesting FAQ.
The feature is enabled by default, but you can disable it in the "Settings". For now, YouTube Suggest seems to be live only for international sites like YouTube UK and only if you search from the homepage, but it should be available at YouTube's main site in the near future.
To get the suggestions, YouTube uses this simple JSON call:
http://suggestqueries.google.com/complete/search? hl=en&ds=yt&json=t&jsonp=callbackfunction&q=QUERY
where ds=yt defines the search's scope (YouTube), while q=QUERY includes the characters typed by the user. A similar URL is used by Google News to suggest news sources in advanced search, so we can expect an API for query suggestions:
http://news.google.com/complete/search? hl=en&ds=ns&js=true&q=QUERY
This URL works as well:
http://suggestqueries.google.com/complete/search? hl=en&ds=ns&json=t&jsonp=callbackfunction&q=QUERY
YouTube constantly experiments with new features and most of them are related to the way people navigate the site or discover new videos. A recent experiment added a search box below the list of related videos so that people can search and see the search results while watching a video. The only problem was that you couldn't add the results to the Quicklist in order to build dynamic playlists.
Update (May 16): YouTube Suggest is now live at youtube.com.
April 24, 2008
YouTube Suggest
This blog is not affiliated with Google.


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Who has the cutest hat?
Nothing fixes a bad hair day like a stylish hat. Can you guess which of these stars has the cutest one?
Your score: 0
Which star has the cuter hat?
See how many out of 20 you can get right. Score by clicking on the photo with the most votes.
Good luck!


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Wednesday, January 15, 2014
The Berkeley County Sheriff's Office Drug Enforcement Unit arrested and charged a wanted man after methamphetamine and marijuana were found in a Sandy Run Circle home near Summerville.
On Jan. 8, agents arrested Daniel A. Thornburg, 23, of Summerville, on charges of possession with intent to distribute marijuana and possession with intent to distribute methamphetamine at a residence located on Sandy Run Circle.
Deputies also learned Thornburg was wanted on six outstanding warrants from other area law enforcement agencies for charges including assault and battery third degree, driving under suspension and animal cruelty. His bonds for the meth and marijuana charges were set at $10,000 each while bond for the ill treatment of animals and assault and battery charges were set at $1,092 each, totaling out at $22,184 in bonds.
Bonds have not been set for his two other charges of driving under suspension and contempt of court.
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[QUOTE=staropeace;557796]I cannot imagine living in a country where folks can own handguns and assorted arms. It is bad enough here where guns are hard to get. It is a hugh crime here to carry a gun. I do not really believe that if guns are outlawed, only outlaws will have guns. If they are impossible to own then that will cut down shooting death and accidental deaths when children find them in the home. We do not have many accidental deaths like that in Canada.[/]
I should clarify my last post, when I say hard time understanding what I mean is a hard time understanding the difference in laws between Canada and the US and a hard time understanding how firearms are so easy to get (Walmart) for example, I don't even think firearms are for sale in my local Walmart/Bass Pro Shop ect.