text:
Anthony Bennett, NBA's top draft pick, offers advice to students in old neighbourhood
Published Thursday, July 4, 2013 2:04PM EDT
Last Updated Thursday, July 4, 2013 2:10PM EDT
Basketball phenom Anthony Bennett, the only Canadian ever drafted first-overall to the NBA, had some words of advice for youth in the Toronto neighbourhood where he grew up: work hard and stay in school and anything is possible.
The Brampton native met with students at the Jane and Finch Boys and Girls Club on Thursday afternoon – the same club where he spent time as a boy.
"The most important thing is to stay in school, make sure you finish school, that's all I can really say," Bennett told students. "If you guys have a dream you can accomplish it because I came from just down the street, I'm just like you guys. It's a tough neighbourhood and now I made it, everything is here."
A freshman at UNLV, Bennett was selected first overall in the June 27 NBA draft, snapped up by the Cleveland Cavaliers.
The 20-year-old Brampton, Ont. native made history by becoming the first Canadian ever drafted in the top spot, joining the ranks of other top-picked basketball legends that includes Shaquille O'Neal, LeBron James and Magic Johnson.
Bennett said regardless of circumstances, young people can be a success if they focus and work hard, no matter what their goals are.
"I remember when I was in your spot, I used to go to that school right there, Yorkwoods (Public School), and come over here to the Boys and Girls Club, so this is great. It's a great feeling to come back and see all you guys, you guys are doing well, and see my old friends," Bennett said.
Students like Ronelle Barnett took his inspiring message to heart.
"He's teaching us to follow our dreams and be whatever we want to be and accomplish all our goals," said Barnett, who wants to be a lawyer when she grows up.
Bennett surpasses the previous highest Canadian draft pick Tristan Thompson, also of Brampton, who was selected fourth overall in 2011. Thompson also went to the Cavs, meaning the pair will be teammates this season.
A star on Canada's junior national team, and the Mountain West Conference player of the year, Bennett was expected to be highly sought after. However, there was little expectation leading up to the draft that he would go first. In fact, many observers expected Bennett to enter the draft next year.
He had rotator cuff surgery in May, but said he was doing fine and didn't expect it to affect his draft selection.
Bennett leads a pack of up-and-coming Canadian basketball stars invading the NBA.
Another Canadian, Kelly Olynyk of Kamloops, B.C., was taken No. 13 by the Boston Celtics.
Vaughan, Ont. native Andrew Wiggins, still a teenager, is going to the Kansas City Jayhawks next season and is expected to be in the running for the 2014 first overall NBA draft pick spot.
More News from CTV Toronto
- Family seeking liver for baby girl 'touched and overwhelmed' by response
- TTC puts an end to Sunday-only streetcar stops
- Kingston police warn pet owners of fake 'animal control' van
- Ex-Ontario deputy minister given 3-year sentence for child porn offences
- Elementary teachers' union confirms details of next steps in strike action


text:
Dawsonville Northeast Georgia Mountains
Dawsonville is situated just north of Atlanta along Georgia's Hospitality Highway. It is home to the Southern Terminus of the 2,146-mile Appalachian Trail, Amicalola Falls State Park with a waterfall that drops 729 feet into a reflection pool, and the Dawsonville Moonshine Distillery. Auto racing has a long history in this area and a popular destination for all NASCAR fans is Gordon Pirkle's Dawsonville Poolroom. A short distance away is the Georgia Racing Hall of Fame. In the fall, Dawsonville comes alive with Uncle Shuck's and Buck's Corn Mazes. Pumpkins in every size and shape can be found at Burt's Farm and at Bradley's Pumpkin Patch. For the less ambitious hiker, there is Dawson Forest and for the paddler, the Etowah and the Amicalola Rivers offer two great river adventures.
Visitor Information Center
44 Commerce Drive
Dawsonville, GA 30534
Phone: 706-265-6278
OfficialVisitor Information
Free Georgia Travel Guide
The state's official Travel Guide is your complete resource to planning a vacation in Georgia. Find trip ideas, attractions, events, activities, accommodations, maps, travel resources and much more.
Website: http://www.exploregeorgia.org
Phone: 1-800-VISIT GA (847-4842)
Dawsonville Travel Guides
2015 Mountain Moonshine Festival Car Show
Enjoy vendors, arts & crafts, food, live music, kids games, petting zoo, and more all weekend long
Website: http://www.kareforkids.us/festival.html
Phone: 706-216-5273
Dawson County Visitor's Guide
Create your own adventure...
Website: http://www.destinationdawsonville.org
Phone: 706-265-6278
River Park Canoe Launch Brochure
The Scenic Etowah River promises to provide many amazing adventures! Bring your family and friends and enjoy this beautiful piece of Dawsonville, Georgia.
Website: http://www.dawsoncounty.org/departments/dawson-county-parks-and-recreation/facilities-and-parks/#river
Phone: 706-344-3646
Jungle Paradise Daylilies929 Mill Creek DriveView on Map
706-265-2130Jungle Paradise in North Georgia is a fun, relaxing place for anyone to enjoy viewing many rare and unusual flowers, as well as our special daylilies. There is a stream... Find Out More
Georgia Racing Hall of Fame415 Hwy. 53 EView on Map
706-216-7223Georgia's Official Racing Hall of Fame hosts special events associated with Georgia's rich racing history and much more. Outside the museum, find vintage race cars,... Find Out More
Amicalola Falls State Park & Lodge418 Amicalola Falls Lodge RoadView on Map
706-265-8888Spectacular scenery and hiking trails make Amicalola Falls State Park & Lodge one of Georgia's most popular state parks. At 729 feet, Amicalola Falls is the tallest... Find Out More
Appalachian Trail - Approach Trail418 Amicalola Falls Lodge RoadView on Map
706-265-8888An 8-mile approach leading from Amicalola Falls State Park begins the 78-mile Georgia portion of this famous hiking trail to Maine. Springer Mountain, the southern terminus... Find Out More
Amicalola Falls State Park & Lodge418 Amicalola Falls Lodge RoadView on Map
706-265-8888Spectacular scenery and hiking trails make Amicalola Falls State Park & Lodge one of Georgia's most popular state parks. At 729 feet, Amicalola Falls is the tallest... Find Out More
Amicalola View Cabin200 Sign Board Gap RdView on Map
706-265-8154Amicalola View Cabin has two bedrooms and 1.5 bathrooms. The cabin is equipped with central heat and air, washer and dryer, and everything needed to make for a lovely... Find Out More
Super 8 Dawsonville205 N 400 Center LaneView on Map
706-216-6801Welcome to the Super 8 in Dawsonville, GA with easy access to GA-400. We are an interior corridor hotel conveniently located near all of the major restaurants in Dawsonville... Find Out More
Under the Hemlock Campgrounds5545 Hwy 52View on Map
706-265-4603Looking for quiet camping? This is the place. Nestled in the heavily wooded foothills of the Appalachian Mountains, only 1 mile west of Amicalola State Park, and just... Find Out More
48th Annual Mountain Moonshine FestivalOct 24, 2015 - Oct 25, 2015Georgia Highway 9View on Map
706-216-5273Join us for the 48th Annual Mountain Moonshine Festival and Car Show. All proceeds support KARE for Kids, Inc., a non-profit organization in Dawson County. This event... Find Out More
3rd Annual Shine Pedalers MetricJul 25, 2015 - Jul 25, 2015415 Highway 53 EastView on Map
706-265-6278This is a challenging ride through the scenic North Georgia mountains beginning in the "Moonshine Capital of the World"! This ride offers a Half-Metric and Metric route... Find Out More
Pups in the Park Presented by Dawson County Humane SocietySep 26, 2015 - Sep 26, 2015445 Martin RoadView on Map
706-265-9160The Pups in the Park Dog Show will entertain you with a wide variety of lively events and activities designed to put a smile on your face, as well as Fido's. Enter your... Find Out More
Dawsonville Music and Beer FestivalAug 21, 2015 - Aug 22, 2015415 Highway 53 EastView on Map
404-851-7768Join us for the Dawsonville Music & Beer Festival August 21-22, 2015. Vendor applications are now available. Please email firstname.lastname@example.com to have... Find Out More
The Varsity93 Bethel DrView on Map
Domino's Pizza6625 Highway 53 EView on Map
Quiznos837 Highway 400 SView on Map
Chick-Fil-A797 Highway 400 SView on Map
The dining information on this page is supplied by the Georgia Restaurant Association.

subset: commoncrawl


text:
Latest Stephen Colbert Stories
Colbert, Share Fair Nation, and ScanSource fund every South Carolina classroom request for Teacher Appreciation Week NEW YORK and GREENVILLE, S.C., May 7, 2015 /PRNewswire-USNewswire/
Last year's dinner raised an unprecedented $3.4 million to support the Ad Council and its 50 national public service campaigns NEW YORK, July 29, 2014 /PRNewswire/ -- The Ad Council,
NEW YORK, April 23, 2014 /PRNewswire/ -- Eight Inc.
Analyzing the voting behavior of users on Ranker.com reveals that in choosing Stephen Colbert, CBS is indeed addressing a need to compete for younger, more pop culture savvy viewers.
NEW YORK, April 10, 2014 /PRNewswire/ -- The CBS Television Network today announced that Stephen Colbert, the host, writer and executive producer of the Emmy and Peabody Award-winning "The Colbert
Reputation Maxx, an industry-leading online reputation management firm, is sharing tips to deal with the recent "racist" tweet sent out by Steven Colbert and the Colbert Report. SCOTTSDALE,
Nation's Largest Pistachio Grower Asks America to "Count Our Nuts" for Chance to Win $100,000; Unveils New Campaign Theme LOS ANGELES, Feb.
Wonderful Pistachios Returns to the Super Bowl with Two New Spots, New Campaign Theme LOS ANGELES, Jan.
Latest Stephen Colbert Reference Libraries
Aptostichus stephencolberti is a species of trapdoor spider named after the American satirist Stephen Colbert. The spider was discovered on the coastline of California in 2007. This species can be found on coastal dunes that extend from the Big Sur region to the San Francisco peninsula at Point Lobos and Golden Gate. Compared to the closely related species such as Aptostichus angelinajolieae, Aptostichus stephencolberti is lighter in coloration. The male holotype and the female paratype...
- A handkerchief.
- Specifically— The legendary sweat-cloth; the handkerchief of St. Veronica, according to tradition miraculously impressed with the mask of Christ; also, the napkin about Christ's head (Johu xx. 7).
- In general, any miraculous portrait of Christ.


text:
Related Pins
The white blue-eyed animals are Spirit teachers and should be protected. Bow acknowledgement and ask for their teaching...then listen and be thankful. The Tiger beings are teachers of power, inner strength and survival and independence as well as understanding family dynamics and values and how to balance these things. Johan Adkins
I don't usually ride English. More western riding for me. But I have to admit, this is really pretty!
Badass mule… Cutting western quarter paint horse appaloosa equine tack cowboy cowgirl rodeo ranch show ponypleasure barrel racing pole bending saddle bronc gymkhana
nice curly hair:)! pic from www.thepioneerwom...
!Brought to you by Cookies In Bloom and Hannah's Caramel Apples www.cookiesinbloo... www.hannahscarame...
Amazing shot by Houston photographer Tracy Manford.
.Azteca horse Pura Raza Espanola Yeguada Herrera Caballos Espanoles Caballos Bailadores Andalusian Lusitano Lippizzaner spanish horse Piccador Vaquero Charro


text: New stories Upcoming Incoming 0° Let's Play - GTA V Heists - The Pacific Standard Job 17m ago - Geoff, Michael, Ryan and Jack kick off the last of the GTA V heist missions! | Culture Comments (0) Source 10° The Wticher 3 1.03 VS 1.04 High/Ultra with Raw Capture 22m ago - We were all very excited to hear the news that patch 1.04 of the witcher 3 PC released earlier to... | PC Comments (0) Source Ad Start Making Games for the PS4 Now - Want to design the next generation of video games? Start learning game design today. Click for more info on how to get started. | Promoted post Read More SiteBot 0° World In Audition Philippines Is Now Open 39m ago - The casual multiplayer online game World In Audition just recently open it's doors to all players... | PC Comments (0) Source 0° Nitro Nation Online Cheats: 4 Tips to Become the King of the Road 47m ago - Nitro Nation Online is an awesome drag racing game by Creative Mobile, that's available for both... | iPhone Comments (0) Source 0° AdVenture Capitalist Tips & Tricks: 5 Hints to Become the Richest Person on the Moon 49m ago - In Kongregate's popular strategy game, AdVenture Capitalist, you can earn more than you've ever d... | iPhone Comments (0) Source


text:
Bolt rules Britannia again as fastest man on the planet sprints to victory at Anniversary Games
Watch out Moscow, Usain Bolt is getting quicker. The six-time Olympic champion ran 9.85sec, his fastest time this season, to win the men's 100m at the Anniversary Games on Friday night.
It was a technically poor run from the Jamaican, who laboured out of the blocks before powering through in the last 40 metres to beat Michael Rodgers and Nesta Carter into second and third. But it was the result athletics needed after a torrid fortnight, and a performance the packed Olympic Stadium certainly wanted to see.
Scroll down for video
Easy does it: Bolt won comfortably despite a poor start
Bolt from the blue: The sprint star turned up on a giant rocket-shaped truck
1) Usain Bolt (Jam) 9.85
2) Michael Rodgers (USA) 9.98
3) Nesta Carter (Jam) 9.99
4) Kim Collins (SKN) 10.03
5) Dwain Chambers (GBR) 10.10
6) Rakieem Salaam (USA) 10.14
7) Christophe Lemaitre (Fra) 10.23
*James Dasaolu (GBR) DNS
Bolt was back in London: winning, running a barefoot lap of honour and pulling his famous 'Lightning Bolt' pose on the finish line. This guy certainly knows how to put on a show.
The 26-year-old had entered the stadium on a rocket before the action started, looking particularly cool and relaxed in his sunglasses. If there were any lingering doubts as to who the star attraction was on Friday night, this surely dispelled them. It is desperately unfair on the other elite athletes but Friday night really did feel like a countdown to 'Bolt time'. Thankfully, however, the big man delivered.
On your marks: The racers get ready to go
'The crowd here is unbelievable,' said Bolt. 'They're wonderful. It's good to be back here. I've got a lot of love for this stadium and this crowd. For the first time in a long while I was slightly nervous. I knew it was going to be a big crowd but when I got out there I saw that it was ram-packed and the energy was still like the Olympics.
'The start was horrifying for me but I think it's just race rust and I just need to get a few races in. I'm feeling good. It was nice to get the win and I'm confident going into Moscow.'
Full flow: Bolt bursts through the field
James Dasaolu, who became the second quickest Briton of all time by running 9.91 a fortnight ago, withdrew from the men's 100m 'A' race less than 10 minutes before the gun, citing feeling a tight hip flexor. Although Dasaolu's priority is next month's World Championships, he may also have been unwilling to show his hand too early against the fastest man in history. The Briton, 25, had been drawn next to Bolt in lane four, after all.
There was another quick time in the men's 200m as Bolt's compatriot Warren Weir, the Olympic bronze medallist, stormed to victory in 19.89, with fellow Jamaican Jason Young also dipping under the 20-second barrier in 19.99.
Winning moment: The Jamaican star crosses the line ahead of his rivals
But there was disappointment for the British trio of Richard Kilty, James Ellington and Delano Williams who, perhaps hampered by their tight inside-lane draws, occupied the last three places.
Adam Gemili will run for Great Britain in the 200m in Moscow but has been overlooked for the 100m after failing to run the 'A' qualification standard. The 19-year-old has insisted this is all part of his plan but he got the better of Harry Aikines-Aryeetey, who was selected ahead of him for the 100m at the World Championships, on Friday night.
Walk in the park: Bolt never looked in any danger of not winning the race
Taking the plaudits: Bolt salutes the adoring London crowd
Olympic semi-finalist Gemili recovered from a poor start to beat an all-British cast in the 100m 'B' race, winning in a season's best of 10.16. But the talented teenager needed a strong final 20 metres and a photo finish to edge out Aikines-Aryeetey.
Gemili said: 'I feel in a lot better shape than I was last year but the race itself wasn't brilliant again. I know if I can execute my race well, then I can run quicker.'
Memento: Bolt throws his running spikes into the crowd
Sealed with a kiss: Bolt's return to London went according to plan
- Fan storms onto court to take a selfie with Roger Federer
- Didier Drogba: A trip down memory lane with a Chelsea great
- Sportsmail's Big Match Stats: Stoke City 6-1 Liverpool
- Chelsea players celebrate with fans on open top bus parade
- 'Danke Jurgen' - Dortmund perform touching tribute to Jurgen...
- Sportsmail's Big Season Stats: Manchester United 2014/15
- Sportsmail's Big Match Stats: Arsenal 4-1 West Brom
- Lee Daniels catches Taraji Henson twerking in tiny bikini
- Josh Duggar makes incest joke on episode of 17 Kids and...
- Horrible moment woman snatches football shirt from young fan
- Heartwarming moment soldiers surprise their sister with...
- Sikh Samaritan receives brand new furniture for his home
- Cristiano Ronaldo's new love interest? Alessia Tedeschi has...
- Real Madrid SACK manager Carlo Ancelotti, announces...
- Jamie Redknapp's end-of-season Premier League verdict......
- Stoke City 6-1 Liverpool: Steven Gerrard's final game for...
- Manchester United squad paint the town red as manager Louis...
- Premier League table: Chelsea pocket £24.7m for winning...
- Raheem Sterling laughs after Liverpool supporters berate him...
- Brendan Rodgers blew £115m on failed Liverpool title bid and...
- Jermaine Pennant in no rush to discuss Wigan future as he...
- Radamel Falcao told his Manchester United career is over......
- Roger Federer angered by French Open security as an intruder...
- Chelsea boss Jose Mourinho gives Premier League winners'...


text:
Pronunciation: Epiphanes
Added on: 2013-03-17 Listened: 84 timesin: gnostic, ancient Greek, author, dynasty, Ancient Egypt, classics, king, Greek gods
Pronunciation in English [en]
- Pronunciation by mforster1uk (Male from United Kingdom)
Could you do it better? different accent? Pronounce Epiphanes in English
Accents & languages on maps
- Random word: fancied
Not satisfied?
Modify word:
· Add languages
· Add categories
Report word:
Is there anything wrong with this word?
Please report it here.


text:
UMass Law awarded 56 students the degree of Juris Doctor during Commencement ceremonies at the Bailey Auditorium.
More than 1,900 undergraduate and graduate students are celebrating their academic achievements in Commencement ceremonies this weekend.
Achievements, dreams, and next steps from some of our graduates. Remember to share your own Corsair pride and future plans on Twitter, Instagram and Facebook.
Commencement spotlights
Martin T. Meehan, a former U.S. congressman who became chancellor of his alma mater, UMass Lowell, was unanimously elected as the next president of the five-campus UMass system.
Junior graphic design major Maria Amell created a Facebook page that portrays the spirit of the UMass Dartmouth community.
UMass Dartmouth is ranked #6 out of the 50 most affordable public schools in the U.S. for in-state students, and #17 in its affordability for out-of-state students.
More points of distinction


text:
Genre: Simulation - Flight Simulation - Publisher: Kalypso Media - Age Rating: 16+
Genre: Simulation - Publisher: Flight 1
Genre: Simulation - Age Rating: 3+
Genre: Simulation, Action/Adventure - Publisher: Koch
Genre: Shooter, Action/Adventure - Publisher: Pqube - Age Rating: 16+
Genre: Sports - Publisher: Namco Bandai - Age Rating: 3+
Genre: Racing/Driving - Age Rating: 3+
Genre: Simulation - Publisher: Aerosoft
Genre: Action/Adventure, Space/Flight Combat Simulator
Genre: Flight/Transport Simulation, Simulation - Flight Simulation - Publisher: Just Flight - Age Rating: 3+
Air Conflicts, from 3D People and Bold Games, is an arcade flight simulator game set in World War II, featuring the aircraft of this period and historically inspired missions. The emphasis is on inten...
From Abacus. More and more commuters are taking a long hard look at Air Taxi services. As the Air Taxi Pilot you have at your disposal several planes, including the Cessna Mustang, Safire Jet and Cirr...
Genre: Flight/Transport Simulation - Flight Simulation
This easy to learn air combat game finds the perfect balance between simulation and arcade action, designed specifically for all users! Engaged in a desperate attempt to defend their homeland, players...
Based on the original arcade classic Xonix, AirXonix is a complete 3-Dimensional remake. Moving across the playing area in a futuristic helicopter, the aim of the game is to defeat the hostile objects...
Adrenaline injected...A fast agile aerobatic sports plane AND a stable IFR platform to boot! The Italian SIAI-Marchetti SF260 is capable of rolling at 120 degrees per second at high speed or looping a...
Genre: Simulation, Action/Adventure - Age Rating: 3+
Genre: Action/Adventure, Space/Flight Combat Simulator - Publisher: Flight 1
Dancing with the wind. Air breezes through this woven-straw openwork panama hat by Lierys. The summery lightness for the traveller from Ecuadorian handiwork is given an Indian emphasis by the wild lea...
Description Dancing with the wind. Air breezes through this woven-straw openwork panama hat by Lierys. The summery lightness for the traveller from Ecuadorian handiwork is given an Indian emphasis by the wild lea... more
Description Air-impact-wrench-Sealey-SA2-Fitted-with-rocking-dog-hammer-and-hardened-impact-anvil-Suitable-for-general-garage-use-Features-four-position-adjustable-air-torque-control-and-reversible-action-Air-Imp... more
Description Air-belt-sander-Sealey-SA35-Aluminium-housing-with-articulated-sanding-arm-Features-belt-tracking-control-heavy-duty-nose-roller-and-one-handed-trigger-operation-Air-Belt-Sander-10-X-330mm more
Description Air-blow-gun-with-safety-nozzle-Sealey-SA913-Die-cast-metal-body-with-moulded-handle-and-hanging-point-Palm-type-gun-with-thumb-trigger-control-Supplied-with-jet-and-safety-nozzle-Air-Blow-Gun-with-Sa... more
Description Air-blow-gun-with-safety-nozzle-and-extensions-Sealey-SA914-Composite-valve-body-with-interchangeable-nozzles-and-safety-tip-Includes-100-and-300mm-extensions-gun-body-blanking-plug-and-safety-nozzle-... more
1 2 3 4 5 ›
published 08/09/2013
Fantastic results - makes hair smooth, straight & manageable
Heavy & Expensive
published 26/06/2012
Nice design, look, fit
published 16/04/2014
Leaves a smooth and sleek finish,
Heavy, Knotts my hair up


text:
Stories Tagged "Iowa": Page 2
Displaying 16 to 2 of 2 results.
Displaying 16 to 2 of 2 results.
Related Tags
- Korea
- Fairfield
- Adel
- Des Moines
- Algona
- Fort Madison
- Columbus Junction
- Cedar Rapids
- animals
- South America
- Kalona
- Orange City
- Yellowstone
- beer
- Iowa City
- Washington D.C.
- Waverly
- Africa
- Ames
- Dubuque
- Maytag
- farms
- Sioux City
- organic
- Ankeny
- Oskaloosa
- Centerville
- Yosemite
- Marshalltown
- Spencer
Related IPTV Video
Avian Flu ImpactFull Program: Iowa Agriculture Secretary Bill Northey, Iowa State University Egg Industry Center Director Hongwei Xin and Iowa... 28:50 Play Video
Iowa Agriculture Secretary Northey says bird disposal to pick up pace in...Iowa Agriculture Secretary Bill Northey describes the methods of disposing tens of millions of birds during the... 01:27 Play Video
Governor Bobby JindalFull Program: Governor Bobby Jindal, (R – Louisiana) is the guest on this edition of Iowa Press. The program discusses his two-term... 28:48 Play Video
Jindal: Republicans need to offer smart solutionsLouisiana Gov. Bobby Jindal, a Republican who is considering running for president, made headlines after the 2012... 01:19 Play Video
Jindal: "I don't trust this president" with trade authorityLouisiana Gov. Bobby Jindal, who is considering running for the Republican presidential nomination, says he... 01:34 Play Video
Your Iowa Photos
Post your photos to our Flickr group, The Iowa Journal, to see them featured below.
Tune In
There are no broadcasts currently planned. Please check back for future broadcast dates.


text:
home › event - regional institutions and their impact on the innovation environment in silicon valley
Regional Institutions and Their Impact on the Innovation Environment in Silicon Valley
Conferences & Talks
Tokyo Tech 21st Century COE Program: The Science of Institutional Management of Technology Annual International Symposium [in Japanese]
29 February 2008
Tokyo, Japan
The history of innovation in Silicon Valley and the greater San Francisco Bay Area is frequently explained through the history of the people and companies who made the major technological advances and their personal and organizational triumphs and failures. What is often ignored or relegated to the background is the role that regional institutions played in nurturing the environment and culture in which these people and companies operated and how that role has evolved over time... PARC Vice President of Business Development John Knights examines the evolving roles of these institutions in light of the concurrent globalization of the high technology industry.
upcoming events view all
Ambient Temperature and Pressure Hybrid Desalination System with Energy Recovery
Armin Volkel, Presenter, Mark Stephenson, Author
14 June 2015
Conferences & Talks
Printed Flexible Electronics Systems
Janos Veres
17 June 2015 | Washington, DC
Conferences & Talks
Hardware Without Hardware: Making as little as possible while rapidly exploring novel digital product ideas (Tutorial)
Mike Kuniavsky
23 June 2015 | San Francisco, CA
Conferences & Talks
Ford's Future: An Automaker and Mobility Company
Dr. Ken Washington
25 June 2015 | George E. Pake Auditorium, PARC
PARC Forum
Design Rules and Prototype Examples for Additive Printing of Flexible Electronics
Tse Nga (Tina) Ng, Steve Ready, Gregory Whiting, David Eric Schwartz, Janos Veres
6 July 2015
Conferences & Talks


text: 10 more photos House for sale, Old Road, SK14 3 Beds · 1 Bath · House · Garage · Kitchen · Agent Verified Large three bedroom end terraced property with attached garage. property comprises entrance vestibule, living room , dining room, kitchen, three bedrooms and a family bathroom. Externally there is an enclosed yard and attached garage to the rear of the property. Three Bedrooms Entrance Vestibule... »» new! on The House Shop > Bridgfords £110,000


text:
Articles tagged tree
20 May 2013 // 4:45 AM
Chicago rapper/producer Tree flips a sample of the Elvis classic "Can't Help Falling in Love" and makes the track his own with his gruff, elastic vocal delivery and alternately tough and clever lyricism.READ more
//Mixed media
Tim Bowness "Great Electric Teenage Dream" (video) (Premiere) // Music
Jeremy Pinnell "Big Bright World" (audio) (Premiere) // Music
Tyler Lyle 'The Native Genius of Desert Plants' (album stream) (Premiere) // Music
The Mix Tapes "Just Don't Get It" (audio) (Premiere) // Music
//Pm Picks
Counterbalance: The Avalanches' 'Since I Left You'
// Sound Affects
"Get a drink, have a good time now. Welcome to paradise, and read all about the 305th most acclaimed album of all time. An Australian plunderphonics pioneer is this week's Counterbalance.READ the article


text:
Are you R A DeFronzo?Claim your profile
Publications (555)3737.46 Total impact
Article: 1.8 Initial Triple Combination Therapy is Superior to Stepwise Add-On Conventional Therapy in Newly Diagnosed T2DM (72-OR)[Show abstract] [Hide abstract]
ABSTRACT: Background: In UKPDS stepwise addition of metformin, sulfonylurea, and basal insulin reduced microvascular complications, but A1c rose progressively to > 8.5% and ~ 65% of individuals required insulin therapy aft er 10.5 years. Yet metformin, add SU, add insulin remains the most frequently employed therapeutic recommendation in the US and other countries.09/2015; 11(3):80-81. DOI:10.1007/s12467-013-0033-7
[Show abstract] [Hide abstract]
ABSTRACT: Inflammation and oxidative stress, through the production of reactive oxygen species (ROS), are consistently associated with metabolic syndrome/type 2 diabetes. While the role of Nox2, a major ROS-generating enzyme, is well described in host defense and inflammation, little is known about its potential role in insulin resistance in skeletal muscle. Insulin resistance induced by a high-fat diet (HFD) was mitigated in Nox2-null mice compared with wild-type mice after 3 or 9 months on the diet. High-fat feeding increased Nox2 expression, superoxide production and impaired insulin signaling in skeletal muscle tissue of wild-type mice but not in Nox2-null mice. Exposure of C2C12 cultured myotubes to either high glucose concentration, palmitate or H2O2 decreases insulin-induced Akt phosphorylation and glucose uptake. Pre-treatment with catalase abrogated these effects indicating a key role for H2O2 in mediating insulin resistance. Down-regulation of Nox2 in C2C12 cells by shRNA prevented insulin resistance induced by high glucose or palmitate but not H2O2. These data indicate that increased production of ROS in insulin resistance induced by high glucose in skeletal muscle cells is a consequence of Nox2 activation. This is the first report to show that Nox2 is a key mediator of insulin resistance in skeletal muscle. Copyright © 2015, The American Society for Biochemistry and Molecular Biology.Journal of Biological Chemistry 03/2015; DOI:10.1074/jbc.M114.626077 · 4.60 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Background: Beta cell dysfunction is a core defect in T2DM and chronic, sustained hyperglycemia has been implicated in progressive beta cell failure, i.e. glucotoxicity. The aim of the present study was to examine the effect of lowering the plasma glucose concentration with dapagliflozin, a glucosuric agent, on beta cell function in T2DM individuals. Research Design and Methods: 24 subjects with T2DM received dapagliflozin (n=16) or placebo (n=8) for 2 weeks, and a 75-gram OGTT and insulin clamp were performed before and after treatment. Plasma glucose, insulin, and C-peptide concentrations were measured during the OGTT. Results: Dapagliflozin significantly lowered both the fasting and 2-hour plasma glucose concentrations and the incremental area under the plasma glucose concentration curve (ΔG0-120) during OGTT by -33±5 mg/dl, -73±9mg/dl and -60±12 mg/dlmin, respectively, compared to -13±9, -33±13 and -18±9 reductions in placebo-treated subjects (both p<0.01). The incremental area under the plasma C-peptide concentration curve tended to increase in dapagliflozin-treated subjects, while it did not change in placebo-treated subjects. Thus, ΔC-Pep0-120/ΔG0-120 increased significantly in dapagliflozin-treated subjects, while it did not change in placebo-treated subjects (0.019±0.005 vs 0.002±0.006, p<0.01). Dapagliflozin significantly improved whole body insulin sensitivity (insulin clamp). Thus, beta cell function, measured as ΔC-Pep0-120/ΔG0-120 ÷ insulin resistance, increased by 2-fold (p<0.01) in dapagliflozin-treated versus placebo-treated subjects. Conclusion: Lowering the plasma glucose concentration with dapagliflozin markedly improves beta cell function, providing strong support in man for the glucotoxic effect of hyperglycemia on beta cell function.Journal of Clinical Endocrinology & Metabolism 02/2015; 100(5):jc20143472. DOI:10.1210/jc.2014-3472 · 6.31 Impact Factor
Article: A Novel Insulin Resistance Index to Monitor Changes in Insulin Sensitivity and Glucose Tolerance: the ACT NOW Study[Show abstract] [Hide abstract]
ABSTRACT: Objective: To test the clinical utility of Quantose M(Q) to monitor changes in insulin sensitivity following pioglitazone therapy in prediabetic subjects. M(Q) is derived from fasting measurements of insulin, α-hydroxybutyrate, linoleoyl-glycerophosphocholine, and oleate, three non-glucose metabolites shown to correlate with insulin-stimulated glucose disposal., Research design and methods: Participants were 428 of the total of 602 ACT NOW IGT subjects randomized to pioglitazone (45 mg/day) or placebo and followed for, 2.4 years. At baseline and study end fasting plasma metabolites required for determination of Quantose, HbA1c, and OGTT with frequent plasma insulin and glucose measurements to calculate, Matsuda Index of insulin sensitivity were obtained. Results: Pioglitazone treatment lowered IGT conversion to diabetes (HR=0.25, 95%CI = 0.13-0.50, p<0.0001). While HbA1c did not track with insulin sensitivity, M(Q) increased in pioglitazone-treated subjects (by 1.45[3.45] mg(.)min(-1.)kgwbm(-1) (median[interquartile range]), (p<0.001 vs placebo) as did, Matsuda Index (by 3.05[4.77] units, p<0.0001). M(Q) correlated with Matsuda Index at baseline and change in Matsuda Index from baseline (rho's of 0.85 and 0.79, respectively, p<0.0001) and was progressively higher across close-out glucose tolerance status (diabetes, IGT, NGT). In logistic models including only anthropometric and fasting measurements, M(Q) outperformed both Matsuda and fasting insulin in predicting incident diabetes. Conclusions: In IGT subjects, Quantose M(Q) parallels changes in insulin sensitivity and glucose tolerance with pioglitazone therapy. Due to its strong correlation with improved insulin sensitivity and its ease of use, Quantose M(Q) may serve as a useful clinical test to identify and monitor therapy in insulin resistant patients.Journal of Clinical Endocrinology & Metabolism 01/2015; 100(5):jc20143824. DOI:10.1210/jc.2014-3824 · 6.31 Impact Factor
Article: Peripheral Insulin Resistance and Impaired Insulin Signaling Contribute To Abnormal Glucose Metabolism in Preterm Baboons[Show abstract] [Hide abstract]
ABSTRACT: Premature infants develop hyperglycemia shortly after birth, increasing their morbidity and death. Surviving infants have increased incidence of diabetes as young adults. Our understanding of the biological basis for the insulin resistance of prematurity and developmental regulation of glucose production remains fragmentary. The objective of this study was to examine maturational differences in insulin sensitivity and the insulin-signaling pathway in skeletal muscle and adipose tissue of 30 neonatal baboons utilizing the euglycemic hyperinsulinemic clamp. Preterm (67% gestation) baboons had reduced peripheral insulin sensitivity shortly after birth (M value 12.5±1.5 vs. 21.8±4.4 mg/kg·min in term baboons) and at 2 weeks of age (M value 12.8±2.6 vs. 16.3±4.2, respectively). Insulin increased Akt phosphorylation, but these responses were significantly lower in preterm baboons during the first week of life (3.2-fold versus 9.8-fold). Preterm baboons had lower GLUT1 protein content throughout the first 2 weeks of life (8-12% of term). In preterm baboons, serum free fatty acids (FFA) did not decrease in response to insulin whereas FFA decreased by >80% in term baboons; the impaired suppression of FFA in preterm animals was paired with decreased GLUT4 protein content in adipose tissue. In conclusion, peripheral insulin resistance and impaired non-insulin dependent glucose uptake play an important role in hyperglycemia of prematurity. Impaired insulin signaling (reduced Akt) contributes to the defect in insulin-stimulated glucose disposal. Counter-regulatory hormones are not major contributors.Endocrinology 01/2015; 156(3):en20141757. DOI:10.1210/en.2014-1757 · 4.64 Impact Factor
Article: Transcriptomic Identification of ADH1B as a Novel Candidate Gene for Obesity and Insulin Resistance in Human Adipose Tissue in Mexican Americans from the Veterans Administration Genetic Epidemiology Study (VAGES).[Show abstract] [Hide abstract]
ABSTRACT: Type 2 diabetes (T2D) is a complex metabolic disease that is more prevalent in ethnic groups such as Mexican Americans, and is strongly associated with the risk factors obesity and insulin resistance. The goal of this study was to perform whole genome gene expression profiling in adipose tissue to detect common patterns of gene regulation associated with obesity and insulin resistance. We used phenotypic and genotypic data from 308 Mexican American participants from the Veterans Administration Genetic Epidemiology Study (VAGES). Basal fasting RNA was extracted from adipose tissue biopsies from a subset of 75 unrelated individuals, and gene expression data generated on the Illumina BeadArray platform. The number of gene probes with significant expression above baseline was approximately 31,000. We performed multiple regression analysis of all probes with 15 metabolic traits. Adipose tissue had 3,012 genes significantly associated with the traits of interest (false discovery rate, FDR ≤ 0.05). The significance of gene expression changes was used to select 52 genes with significant (FDR ≤ 10-4) gene expression changes across multiple traits. Gene sets/Pathways analysis identified one gene, alcohol dehydrogenase 1B (ADH1B) that was significantly enriched (P < 10-60) as a prime candidate for involvement in multiple relevant metabolic pathways. Illumina BeadChip derived ADH1B expression data was consistent with quantitative real time PCR data. We observed significant inverse correlations with waist circumference (2.8 x 10-9), BMI (5.4 x 10-6), and fasting plasma insulin (P < 0.001). These findings are consistent with a central role for ADH1B in obesity and insulin resistance and provide evidence for a novel genetic regulatory mechanism for human metabolic diseases related to these traits.PLoS ONE 01/2015; 10(4):e0119941. DOI:10.1371/journal.pone.0119941 · 3.53 Impact Factor
Article: Practical implementation of incretin-based therapy in hospitalized patients with type 2 diabetes.[Show abstract] [Hide abstract]
ABSTRACT: Abstract Hyperglycemia in patients with and without a prior history of diabetes is an independent marker of morbidity and mortality in critically and noncritically ill patients. Improvement of glycemic control with insulin therapy has been shown to reduce hospital complications in patients with diabetes, but also results in increased rates of hypoglycemia, which have been linked to poor outcomes. Thus, alternative treatment options that can normalize blood glucose levels without undue hypoglycemia are being sought. Incretin-based therapies, such as glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors, stimulate insulin secretion in a glucose-dependent fashion, thus not causing hypoglycemia. Alternative points of view exist regarding insulin versus incretin therapy for the care of these patients. We have brought together the authors on the opposite sides of this discussion with the objective of providing a rational synthesis on how to achieve the best possible control of glycemia in the hospital, using both standard insulin approaches and incretin-based therapies to improve patient outcomes. This review examines the benefits of incretin-based therapy in improving glycemic control in hospitalized patients with stress-induced diabetes and in diabetic patients in critical care and non-critical care settings.
[Show abstract] [Hide abstract]
ABSTRACT: In the liver Wnt-signaling contributes to the metabolic fate of hepatocytes, but the precise role of the TCF7L2 in this process is unknown. We employed a temporal RNA-Seq approach to examine gene expression 3-96 h following Tcf7l2 silencing in rat hepatoma cells, and combined this with ChIP-Seq to investigate mechanisms of target gene regulation by TCF7L2. Silencing Tcf7l2 led to a time-dependent appearance of 406 differentially expressed genes (DEGs), including key regulators of cellular growth and differentiation, and amino acid, lipid and glucose metabolism. Direct regulation of 149 DEGs was suggested by strong proximal TCF7L2 binding (peak proximity score > 10) and early mRNA expression changes (≤18 h). Indirect gene regulation by TCF7L2 likely occurred via alternate transcription factors, including Hnf4a, Foxo1, Cited2, Myc and Lef1, which were differentially expressed following Tcf7l2 knock-down. Tcf7l2-silencing enhanced the expression and chromatin occupancy of HNF4α, and co-siRNA experiments revealed that HNF4α was required for the regulation of a subset of metabolic genes by TCF7L2, particularly those involved in lipid and amino-acid metabolism. Our findings suggest TCF7L2 is an important regulator of the hepatic phenotype, and highlight novel mechanisms of gene regulation by TCF7L2 that involve interplay between multiple hepatic transcriptional pathways. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.Nucleic Acids Research 12/2014; 42(22):13646-13661. DOI:10.1093/nar/gku1225 · 8.81 Impact Factor
Article: The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo[Show abstract] [Hide abstract]
ABSTRACT: The molecular mechanisms by which muraglitazar (peroxisome proliferator-activated receptor γ/α agonist) improves insulin sensitivity in Type 2 diabetes mellitus are not fully understood. We hypothesized that muraglitazar would increase expression of 5'-monophosphate-activated protein kinase and genes involved in adiponectin signalling, free fatty acid oxidation and mitochondrial function in skeletal muscle. Sixteen participants with Type 2 diabetes received muraglitazar, 5 mg/day (n = 12) or placebo (n = 4). Before and after 16 weeks, participants had vastus lateralis muscle biopsy followed by 180 min euglycaemic hyperinsulinaemic clamp. Muraglitazar increased plasma adiponectin (9.0 ± 1.1 to 17.8 ± 1.5 μg/ml, P < 0.05), while no significant change was observed with placebo. After 16 weeks with muraglitazar, fasting plasma glucose declined by 31%, fasting plasma insulin decreased by 44%, insulin-stimulated glucose disposal increased by 81%, HbA1c decreased by 21% and plasma triglyceride decreased by 39% (all P < 0.05). Muraglitazar increased mRNA levels of 5'-monophosphate-activated protein kinase, adiponectin receptor 1, adiponectin receptor 2, peroxisome proliferator-activated receptor gamma coactivator-1alpha and multiple genes involved in mitochondrial function and fat oxidation. In the placebo group, there were no significant changes in expression of these genes. Muraglitazar increases plasma adiponectin, stimulates muscle 5'-monophosphate-activated protein kinase expression and increases expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation. These changes represent important cellular mechanisms by which dual peroxisome proliferator-activated receptor agonists improve skeletal muscle insulin sensitivity. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Diabetic Medicine 12/2014; 32(5). DOI:10.1111/dme.12664 · 3.06 Impact Factor
Article: Initial Combination Therapy with Metformin/Pioglitazone/Exenatide is More Effective Than Sequential Add-On Therapy in Subjects with New Onset Diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT): A Randomized Trial.[Show abstract] [Hide abstract]
ABSTRACT: ADA and EASD recommend lowering HbA1c in T2DM individuals to as close to normal as possible while avoiding hypoglycemia. We hypothesized that initiating therapy with a combination of agents known to improve insulin secretion and insulin sensitivity in subjects with new onset diabetes would produce greater, more durable HbA1c reduction while avoiding hypoglycemia and weight compared to sequential addition of agents that lower plasma glucose but do not correct established pathophysiologic abnormalities. Research Design and Methods Drug naïve, recently diagnosed T2DM subjects were randomized in an open fashion design in a single center study to metformin/pioglitazone/exenatide (Triple Therapy) (n = 106) or escalating dose of metformin followed by sequential addition of sulfonylurea and glargine insulin (Conventional Therapy) (n = 115) to maintain HbA1c < 6.5 for 2 years. Subjects receiving Triple Therapy experienced a significantly greater reduction in HbA1c versus Conventional Therapy (5.95% vs 6.50 %, p < 0.001). Despite lower HbA1c , subjects receiving Triple Therapy experienced 7.5-fold lower rate of hypoglycemia versus subjects receiving Conventional Therapy. Subjects receiving Triple Therapy experienced mean weight loss of 1.2 kg versus mean weight gain of 4.1 kg (p < 0.01) with Conventional Therapy. The results of this exploratory study demonstrate that combination therapy with metformin/pioglitazone/exenatide in newly diagnosed T2DM patients is more effective with less hypoglycemia than sequential add-on therapy with metformin, sulfonylurea, and then basal insulin. This article is protected by copyright. All rights reserved.Diabetes Obesity and Metabolism 11/2014; 17(3). DOI:10.1111/dom.12417 · 5.46 Impact Factor
Article: Metabolites as Novel Biomarkers for Childhood Obesity-Related Traits in Mexican American Children[Show abstract] [Hide abstract]
ABSTRACT: Background/Objectives Although newer approaches have identified several metabolites associated with obesity, there is paucity of such information in paediatric populations, especially among Mexican–Americans (MAs) who are at high risk of obesity. Therefore, we performed a global serum metabolite screening in MA children to identify biomarkers of childhood obesity.Methods We selected 15 normal-weight, 13 overweight and 14 obese MA children (6–17 years) and performed global serum metabolite screening using ultra-performance liquid chromatography/quadruple orthogonal acceleration time of flight tandem micro mass spectrometer. Metabolite values were analysed to assess mean differences among groups using one-way analysis of variance, to test for linear trend across groups and to examine Pearson's correlations between them and seven cardiometabolic traits (CMTs): body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, homeostasis model of assessment-insulin resistance, triglycerides and high-density lipoprotein cholesterol.ResultsWe identified 14 metabolites exhibiting differences between groups as well as linear trend across groups with nominal statistical significance. After adjustment for multiple testing, mean differences and linear trends across groups remained significant (P < 5.9 × 10−5) for L-thyronine, bradykinin and naringenin. Of the examined metabolite-CMT trait pairs, all metabolites except for 2-methylbutyroylcarnitine were nominally associated with two or more CMTs, some exhibiting significance even after accounting for multiple testing (P < 3.6 × 10−3).Conclusions To our knowledge, this study – albeit pilot in nature – is the first study to identify these metabolites as novel biomarkers of childhood obesity and its correlates. These findings signify the need for future systematic investigations of metabolic pathways underlying childhood obesity.Pediatric Obesity 11/2014; DOI:10.1111/ijpo.270 · 2.42 Impact Factor
Article: Chronic Continuous Exenatide Infusion Does Not Cause Pancreatic Inflammation and Ductal Hyperplasia in Non-Human Primates[Show abstract] [Hide abstract]
ABSTRACT: In this study, we aimed to evaluate the effects of exenatide (EXE) treatment on exocrine pancreas of nonhuman primates. To this end, 52 baboons (Papio hamadryas) underwent partial pancreatectomy, followed by continuous infusion of EXE or saline (SAL) for 14 weeks. Histological analysis, immunohistochemistry, Computer Assisted Stereology Toolbox morphometry, and immunofluorescence staining were performed at baseline and after treatment. The EXE treatment did not induce pancreatitis, parenchymal or periductal inflammatory cell accumulation, ductal hyperplasia, or dysplastic lesions/pancreatic intraepithelial neoplasia. At study end, Ki-67-positive (proliferating) acinar cell number did not change, compared with baseline, in either group. Ki-67-positive ductal cells increased after EXE treatment (P = 0.04). However, the change in Ki-67-positive ductal cell number did not differ significantly between the EXE and SAL groups (P = 0.13). M-30-positive (apoptotic) acinar and ductal cell number did not change after SAL or EXE treatment. No changes in ductal density and volume were observed after EXE or SAL. Interestingly, by triple-immunofluorescence staining, we detected c-kit (a marker of cell transdifferentiation) positive ductal cells co-expressing insulin in ducts only in the EXE group at study end, suggesting that EXE may promote the differentiation of ductal cells toward a β-cell phenotype. In conclusion, 14 weeks of EXE treatment did not exert any negative effect on exocrine pancreas, by inducing either pancreatic inflammation or hyperplasia/dysplasia in nonhuman primates. Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.American Journal Of Pathology 11/2014; 185(1). DOI:10.1016/j.ajpath.2014.09.009 · 4.60 Impact Factor
Article: Adjusting Glucose-Stimulated Insulin Secretion for Adipose Insulin Resistance: An Index of β-Cell Function in Obese Adults[Show abstract] [Hide abstract]
ABSTRACT: The hyperbolic relationship between insulin secretion and sensitivity has been used to assess in vivo β-cell function (i.e., the disposition index). The disposition index emphasizes the importance of taking into account both skeletal muscle and hepatic insulin resistance to depict insulin secretion. However, we propose that adipose tissue insulin resistance also needs to be accounted for when characterizing glucose-stimulated insulin secretion (GSIS) because elevated plasma free fatty acids (FFAs) impair β-cell function.Diabetes Care 08/2014; DOI:10.2337/dc13-3011 · 8.57 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: Introduction: The incidence of type 2 diabetes mellitus (T2DM) has risen to epidemic proportions, and this is associated with enormous cost. T2DM is preceded by 'prediabetes', and the diagnosis of impaired glucose tolerance (IGT) and/or impaired fasting glucose (IFG) provides an opportunity for targeted intervention. Prediabetic subjects manifest both core defects characteristic of T2DM, that is, insulin resistance and β-cell dysfunction. Interventions which improve insulin sensitivity and/or preserve β-cell function are logical strategies to delay the conversion of IGT/IFG to T2DM or revert glucose tolerance to normal.Areas covered: The authors examine pharmacologic agents that have proven to decrease the conversion of IGT to T2DM and represent potential treatment options in prediabetes.Expert opinion: Weight loss improves whole body insulin sensitivity, preserves β-cell function and decreases progression of prediabetes to T2DM. In real life long-term weight loss is the exception and, even if successful, 40 – 50% of IGT individuals still progress to T2DM. Pharmacotherapy provides an alternative strategy to improve insulin sensitivity and preserve β-cell function. Thiazolidinediones (TZDs) are highly effective in T2DM prevention. Long-acting glucagon-like peptide-1 (GLP-1) analogs, because they augment β-cell function and promote weight loss, are effective in preventing IGT progression to T2DM. Metformin is considerably less effective than TZDs or GLP-1 analogs.Expert Opinion on Pharmacotherapy 08/2014; 15(14). DOI:10.1517/14656566.2014.944160 · 3.09 Impact Factor
Article: The Disposition Index Does Not Reflect beta-Cell Function in IGT Subjects Treated With Pioglitazone[Show abstract] [Hide abstract]
ABSTRACT: Aims/Hypothesis: The insulin secretion/insulin resistance (disposition) index (ΔI/ΔG÷IR) commonly is used as a measure of beta cell function (Δ=change from baseline). This relationship is curvilinear and becomes linear when log transformed. ΔI is determined by two variables: insulin secretory rate (ISR) and metabolic clearance of insulin (MCRI). We postulated that the characteristic curvilinear relationship would be lost if Δ plasma C-peptide (instead of Δ plasma insulin) was plotted against insulin sensitivity. Methods: 441 IGT individuals from ACT NOW received an OGTT and were randomized to pioglitazone or placebo for 2.4 years. Results: Pioglitazone reduced IGT conversion to diabetes by 72% (p<0.0001). ΔI/ΔG vs Matsuda Index (MI) of insulin sensitivity showed the characteristic curvilinear relationship. However, when ΔCP/ΔG or ΔISR/ΔG was plotted against MI, the curvilinear relationship was completely lost. This discordance was explained by two distinct physiologic effects that altered plasma insulin response in opposite directions: (i) increased ISR and (ii) augmented MCRI. The net result was a decline in plasma insulin response to hyperglycemia during OGTT. These findings demonstrate a physiologic control mechanism wherein the increase in ISR ensures adequate insulin delivery into portal circulation to suppress HGP while delivering reduced but sufficient amount of insulin to peripheral tissues to maintain the pioglitazone-mediated improvement in insulin sensitivity without excessive hyperinsulinemia. Conclusions: These results demonstrate the validity of disposition index when relating plasma insulin response to insulin sensitivity, but underscore the pitfall of this index when drawing conclusions about beta cell function, since insulin secretion declined despite an increase in plasma insulin response.Journal of Clinical Endocrinology & Metabolism 06/2014; 99(10):jc20141515. DOI:10.1210/jc.2014-1515 · 6.31 Impact Factor
Article: Adjusting Glucose-Stimulated Insulin Secretion For Adipose Insulin Resistance: Role Of Exercise On Novel β-cell Function Index[Show abstract] [Hide abstract]
ABSTRACT: Recent work suggests that glucose-stimulated insulin secretion (GSIS) should be adjusted for both skeletal muscle and hepatic insulin resistance to depict β-cell function (i.e. disposition index). However, adipose tissue insulin resistance needs to be accounted for since elevated free fatty acids (FFA) impair β-cell function.PURPOSE: To characterize and validate β-cell function relative to adipose insulin resistance, and test the effects of a 7-day exercise intervention on β-cell function.METHODS: Forty-four subjects (29 F; 59.6±1.3 y; 31.3±0.7 kg/m2), underwent a standard 75g OGTT to determine 1st and 2nd phase GSIS, calculated as area under the curve of insulin divided by glucose during the first 30 and last 60min. [1-14C] palmitate tracer infusions (Ra) were used to assess basal lipolytic rate, and we validated a simplified version of the Ra calculation using plasma as: [1/(FFA*insulin)*GSIS]. Twelve different subjects (11 F; 66.3±1.2 y; 35.1±1.9 kg/m2) underwent 7-days of supervised aerobic exercise (60min/d, ∼85% HRmax) and a 75g OGTT was performed before and after exercise to estimate β-cell function adjusted for skeletal muscle (Matsuda index*GSIS), hepatic ((1/fasting glucose*insulin)*GSIS) and adipose tissue ((1/fastingFFA*insulin)*GSIS) insulin resistance.RESULTS: Plasma FFA and palmitate Ra calculations of 1st and 2nd phase β-cell function were correlated (r=0.86, p<0.001 and r=0.89, p<0.001, respectively) and met hyperbolic criteria. 120min glucose levels were inversely related to 1st and 2nd phase β-cell function (r=-0.86, p<0.0001 and r=-0.90, p<0.001). Exercise had no effect on weight or VO2max, but increased β-cell function relative to changes in skeletal muscle (1st phase Pre: 1.7±0.4 vs. Post: 2.8±0.8, 2nd phase Pre: 1.1±0.1 vs. Post: 1.33±0.2, each p<0.03), but not hepatic (1st phase Pre: 0.23±0.06 vs. Post: 0.30±0.09, 2nd phase Pre: 0.14±0.03 vs. Post: 0.14±0.03, each p<0.87) or adipose insulin resistance (1st phase Pre: 0.13±0.03 vs. Post: 0.13±0.04, 2nd phase Pre: 0.07±0.01 vs. Post: 0.06±0.01, each p<0.61).CONCLUSIONS: Adjusting GSIS for adipose insulin resistance provides an index of β-cell function in obese subjects. Plasma FFA derived calculations may yield additional insight into how exercise influences inter-organ crosstalk for glucose regulation.Medicine & Science in Sports & Exercise 05/2014; 46(5S):157–161. DOI:10.1249/01.mss.0000451129.79793.50 · 4.46 Impact Factor
Diabetes Spectrum 05/2014; 27(2):100-112. DOI:10.2337/diaspect.27.2.100
Article: APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor[Show abstract] [Hide abstract]
ABSTRACT: Binding of insulin receptor substrate proteins 1 and 2 (IRS1/2) to the insulin receptor (IR) is essential for the regulation of insulin sensitivity and energy homeostasis. However, the mechanism of IRS1/2 recruitment to the IR remains elusive. Here, we identify adaptor protein APPL1 as a critical molecule that promotes IRS1/2-IR interaction. APPL1 forms a complex with IRS1/2 under basal conditions, and this complex is then recruited to the IR in response to insulin or adiponectin stimulation. The interaction between APPL1 and IR depends on insulin- or adiponectin-stimulated APPL1 phosphorylation, which is greatly reduced in insulin target tissues in obese mice. appl1 deletion in mice consistently leads to systemic insulin resistance and a significant reduction in insulin-stimulated IRS1/2, but not IR, tyrosine phosphorylation, indicating that APPL1 sensitizes insulin signaling by acting at a site downstream of the IR. Our study uncovers a mechanism regulating insulin signaling and crosstalk between the insulin and adiponectin pathways.Cell Reports 05/2014; 7(4). DOI:10.1016/j.celrep.2014.04.006 · 7.21 Impact Factor
Article: Strong Association Between Insulin-Mediated Glucose Uptake and the 2-Hour, Not the Fasting Plasma Glucose Concentration, in the Normal Glucose Tolerance Range[Show abstract] [Hide abstract]
ABSTRACT: Aim: to examine the relationship between whole body insulin-mediated glucose disposal and the fasting plasma glucose concentration in non-diabetic individuals. Research Design and Methods: 253 non-diabetic subjects with NGT, IFG, IGT and CGI received 75-gram OGTT and euglycemic hyperinsulinemic clamp. Total glucose disposal (TGD) during the insulin clamp was compared in IFG and NGT individuals and was related to fasting and 2-h plasma glucose concentrations in each group. Results: TGD varied considerably between NGT and IFG individuals and displayed a strong inverse relationship with the 2h PG (r=0.40, p<0.0001) but not with the FPG. When IFG and NGT individuals were stratified based upon their 2-h PG concentration, the increase in 2h-PG was associated with a progressive decrease in TGD in both groups, and the TGD was comparable among NGT and IFG individuals. Conclusion: the present results indicate that: (i) as in NGT, insulin-stimulated TGD varies considerably in IFG individuals; ii) the large variability in TGD in IFG and NGT individuals is related to the 2h-PG concentration; (iii) after adjustment for the 2h PG concentration, IFG subjects have comparable TGD to NGT individuals.The Journal of Clinical Endocrinology and Metabolism 05/2014; 99(9):jc20132886. DOI:10.1210/jc.2013-2886 · 6.31 Impact Factor
[Show abstract] [Hide abstract]
ABSTRACT: OBJECTIVE Plasma adiponectin levels are reduced in type 2 diabetes mellitus (T2DM) and other insulin-resistant states. We examined whether plasma adiponectin levels at baseline and after pioglitazone treatment in impaired glucose tolerance (IGT) subjects were associated with improved insulin sensitivity (SI) and glucose tolerance status.RESEARCH DESIGN AND METHODSA total of 602 high-risk IGT subjects in ACT NOW were randomized to receive pioglitazone or placebo with a median follow-up of 2.4 years.RESULTSPioglitazone reduced IGT conversion to diabetes by 72% in association with improved β-cell function by 64% (insulin secretion/insulin resistance index) and increased tissue sensitivity by 88% (Matsuda index). In pioglitazone-treated subjects, plasma adiponectin concentration increased threefold from 13 ± 0.5 to 38 ± 2.5 μg/mL (P < 0.001) and was strongly correlated with the improvement in SI (r = 0.436, P < 0.001) and modestly correlated with glucose area under the curve during oral glucose tolerance test (r = 0.238, P < 0.005) and insulin secretion/insulin resistance index (r = 0.306, P < 0.005). The increase in adiponectin was a strong predictor of reversion to normal glucose tolerance and prevention of T2DM. In the placebo group, plasma adiponectin did not change and was not correlated with changes in glucose levels. There was an inverse association between baseline plasma adiponectin concentration and progression to diabetes in the placebo group but not in the pioglitazone group.CONCLUSIONS Baseline adiponectin does not predict the response to pioglitazone. The increase in plasma adiponectin concentration after pioglitazone therapy in IGT subjects is strongly related to improved glucose tolerance status and enhanced tissue sensitivity to insulin.Diabetes care 04/2014; 37(6). DOI:10.2337/dc13-1745 · 8.57 Impact Factor
Top Journals
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States
- • Division of Hospital Medicine
- • Division of Diabetes
- • Department of Medicine
Karolinska Institutet
Stockholm, Stockholm, Sweden
- Department of Renal Medicine
Southwest Foundation For Biomedical ResearchSan Antonio, Texas, United States
Central South University
Ch'ang-sha-shih, Hunan, China
- Metabolic Syndrome Research Center
Lund University
Lund, Skåne, Sweden
- Department of Clinical Sciences, Malmö
University of Texas Health Science Center at TylerTyler, Texas, United States
University of DundeeDundee, Scotland, United Kingdom
Arizona State University
Mesa, AZ, United States
- School of Life Sciences
University of Texas at San AntonioSan Antonio, Texas, United States
University of MilanMilano, Lombardy, Italy
Università degli Studi di GenovaGenova, Liguria, Italy
Joslin Diabetes CenterBoston, Massachusetts, United States
Università di Pisa
Pisa, Tuscany, Italy
- Department of Clinical and Experimental Medicine
University of Texas at Austin
Austin, Texas, United States
- Department of Kinesiology and Health Education
University of CataniaCatania, Sicily, Italy
Leiden University Medical CentreLeyden, South Holland, Netherlands
University of VeronaVerona, Veneto, Italy
Second University of NaplesCaserta, Campania, Italy
Brigham and Women's HospitalBoston, Massachusetts, United States
It-RoboticsVicenza, Veneto, Italy
The University of Tennessee Health Science Center
Memphis, TN, United States
- Department of Medicine
National Research Council
Roma, Latium, Italy
- Institute of Clinical Physiology IFC
Yale-New Haven Hospital
New Haven, Connecticut, United States
- Department of Diabetes and Endocrinology
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United States
Yale University
New Haven, CT, United States
- • Department of Internal Medicine
- • Department of Psychology
- • School of Medicine
University Hospital of LausanneLausanne, Vaud, Switzerland
University of Lausanne
Lausanne, Vaud, Switzerland
- Institute of Pathology
Helsinki University Central Hospital
Helsinki, Southern Finland Province, Finland
- Department of Medicine
Medical College of Wisconsin
Milwaukee, WI, United States
- Department of Medicine
National Institute of Child Health and Human DevelopmentMaryland, United States


text:
Verified ID
Email AddressVerified
Phone Number▒▒▒▒▒▒▒▒▒ 21
374 Friends
Reviewed3 Reviews
Offline IDIdentification Card
About Me
- School
- RSG Wiringherlant, Universiteit Utrecht
- Work
- Chellomedia, The Affordable Art Fair Amsterdam
- Florine's Airbnb Symbol
Hey, I'm Florine!
Alkmaar, Noord-Holland, The Netherlands · Member since December 2012
You have reported this user. Undo?
Hi there! My name is Florine, 26 years old and always looking for roads less travelled and special places to stay. I have a lovely boyfriend who's joining me on this quest, so it will always be the two of us! We love music (vinyl, especially), art, reading books, taking hikes, enjoying nature, drinking beers and eating pie. We love to meet new people and like know a place by the experience of the locals. If you would like to know more, don't hesitate to contact me!


text:
No Free Readings No Free Readings No time wasting between the readings Quick connection and fast reading. Love psychic ...
I'm Alex, and I am here for you. No Nonsense. No guesswork. No wasting your time. No pity. No telling you what I ...
Special Offer: Flat fee! $30 for 30 minutes
No free readings, No refunds for services rendered. Plz don't ask * With the help of my guides Bo & Margie We ...
Special Offer: 15 Min $40, 20 Min $60, 30 Min $80 reg'd clients only MUST REQUEST
Search Results for medicine
Divine Love Specialist (divine_love_readings)
Accurate Detailed Predictions Time Frames that Come to Pass! ❤ RELATIONSHIP ... I am an experienced reader with years of expertise. I am proficient in Relationship Advice, Psychic Readings, Emotional Healing , Positive Energy Reinforcement, Aura Cleansing,Psychic Readings , Spiritual Counseling and more. Personal Development and Living in Balance with your partner or other relationships ...
$5.99 per minute Special Offer: ❤10 min $40 ❤15 min $60 ❤ 20min $80 ❤ 30 min $120 ❤ All Prepaid! ❤
Angel Therapy Astrology Break up Cheating Clairvoyant Divorce Dream & Photo Interpretation Empath Energy Reader Family Issues Life Coaching
Psychic Medium Spirtual Teacher Drita provides guidance and support to help you find the right solutions to your problems. If you are looking to reach your potential in life, love or career you need look no further for an accurate reading of future events. I have trained in the Vibrational Expansion Technique of Energy Therapy. With and ...
My $10 deal: Get 15 minutes for $30special!
$2.99 per minute Special Offer: Free first 2 minutes
Antonella Vivianne Ercolani (antouk1)
Northern Lights Sanctuary BodyTalk Distance Sessions Distance/Remote BodyTalk System Sessions, cutting edge energy medicine to help you heal. Let me know your issues, physical, emotional, spiritual, relationship related In Bodytalk your body's innate wisdom is contacted so that a truly effective and personalized healing can take place I also do Psychic ...
My $10 deal: Free 20 min chat for prospective BodyTalk clients
€1.05 per minute Special Offer: 3 distance BodyTalk sessions for half price! Leave me a Message
Bodytalk allergies alternative healing cleansings complementary healing energy healing feelings future future readings headache healing
Love.Expert.Amandra Vedic Astrology touches your hidden power to overcome from your difficulites and Spiritual power gives you right path of life and a chance to be Winner in your life.I am Empath, I do Channeling, Card Readings and Energy Healing.
$0.80 per minute Special Offer: Free introduction and get complete reading in $10
Erika Black ♥Love Expert♥ (nononsense)
Spiritual Healer & Adviser Erika - No Nonsense Readings 94% accurate - Not for ... Hello, welcome to my page. My name is Erika, I have been a Spiritual Healer & Adviser for over 25 years. If you want to hear someone sugar coating just for the sake of pacifying you, then I do not advise contacting me. But if you want to hear the truth. If you want to hear the answers to your problems in ...
My $10 deal: Three questions: $10.00
$1.79 per minute Special Offer: Weekends only one free question!
accurate advice career depression energy expert healing help honest love lovers
Readings on Love, Money and Health Hello and welcome! I work only with higher vibrations, been working with Arch Angel Micheal for over 33 years, I do energy work long distance and will assist you in learning how to help yourself with this divine energy. I have been reading tarot for over 28 years and healing people for more than 15 years so ...
My $10 deal: 3 questions any subject
$1.22 per minute Special Offer: $20 half an hour, any subject
Energy work healing tarot cards and Native American teachings.
Sophera Light Hello My name is Sophera Light, a name that has meaning of love, loyalty and courage and that is what I would like to offer and share with you in a reading. I am a empath, a clairvoyant and have done some channeling work as well. I am also a tarot reader, Reiki Master, Pow-wow practitioner which all have ...
My $10 deal: 6 min for 10 dollars
$1.50 per minute Special Offer: Detailed email reading for 10 with answeres to 3 additonal questions
Psychic Reading Reiki Master Sophera Light clairvoyant tarot tarot reader
♥ Psychic Stephanie ♥ (psychicexpert143)
Accurate Detailed Predictions Time Frames that Come to Pass! ❤ RELATIONSHIP ... unlock the door to the future know what's in store for you If u have questions on a relationships and if u are in love with someone and u want to make sure they are the correct person that u belong with for the career that you're in is not for you my readings can give you life directions and help ...
My $10 deal: GET ONLY GENUINE READING NO Mumbo Jumbo!!
$1.50 per minute Special Offer: ❤ Full clarity and best advice $45 full life reading :)
ntuitive Love advisor career coaching guidance relationships tarot truth
Advisor Mia (psychic_advisor_mia)
☪Advisor Mia - Certified Psychic Consultant, Life Coach, Spiritualist, Love ... Spiritual Psychic Energy Specializing in all Love, Soulmates and Relationship Areas During a Reading I feel visions and predict situations ready to happen, I read the energy at a very fast pace, this is because I am getting Information from spirit guides and interpret the spiritual messages I am a Forth ...
My $10 deal: 15 Minutes-$20 25 Minutes-$30 30 Minutes-$40
$1.50 per minute Special Offer: Open- Minded and will never Judge a Child of God
Angel Cards Career Confusion Future Healings Love Lovers Past Present Psychic Relationships
Shamanic Coach & Practitioner Spirit:::Body:::Heart:::Mind:::Soul "Yesterday I was clever, so I wanted to change the world. Today I am wise, so I am changing myself." – Rumi Change in your life begins with change in yourself. It's that simple, yet it is not easy. Online Shamanic Coaching sessions help most by providing a shift in perspective, and guiding ...
My $10 deal: ★ Chakra Scan OR 3 Card Osho Zen Tarot Reading ★
$1.50 per minute Special Offer: Todays Deck: OSHO ZEN TAROT
Animal Guide Balance Beauty Healing I Ching LGBT Love Magic Medicine Mystic Past Lives


text:
Manage Subscriptions
Log Out
Log In
An area fighter who blew out his knee 14 months ago is days away from headlining a UFC event in Brazil.
The widow of world champion boxer Johnny Tapia says she's afraid for her life.
A family feud is brewing over one of Albuquerque's most famous sons, the late world champion boxer Johnny Tapia.
This Thursday and Friday, a 91-year-old resident played in the Albuquerque Fairway Frolics.
Student drug testing in high schools is a controversial topic, but Rio Rancho is looking at putting a policy on the books.
NBA star Kevin Durant got paid big bucks for making 24 steals this season. But prosecutors have called a foul on two New York airport employees who allegedly swiped 24 not-yet released sneakers from his Nike collection.
An appeal hearing for New England Patriots quarterback Tom Brady's four-game suspension over Deflategate will begin June 23, according to a report on Friday.
On the final run in the final seconds of the third and final round of Friday's knockout qualifying session at Dover International Speedway, Denny Hamlin knocked Martin Truex Jr. off the pole for Sunday's FedEx 400 benefiting Autism Speaks NASCAR Sprint Cup Series race.
Golden State Warriors guard Klay Thompson, who had taken a knee to the head in Wednesday night's series-clinching win over the Houston Rockets, was diagnosed with a concussion after seeing a neurologist Friday.
The Southeastern Conference will distribute an NCAA-record $435 million, with each of the 14 schools receiving $31.01 million, ESPN.com reported Friday.
So much rain has fallen this May on flood-ravaged Texas that it could cover the entire state with 8 inches of water, meteorologists say.
And it ain't over yet.
Every drop of rain these days is a drop too many in much of Texas, where 22 people have died...
No email address was supplied by
To complete your registration on this site, please supply an address.
Please confirm or modify the email address to which you will have subscription offers sent.
For a more personalized experience, please supply the following optional information.


text:
November 8, 2010 in Region
Trial starts for 4 accused of aiding in Lakewood killings
TACOMA — Lawyers presented opening arguments today in Tacoma in the trial of four people accused of helping Lakewood police killer Maurice Clemmons.
Pierce County prosecutors charged Rickey Hinton, Eddie Lee Davis, Douglas Edward Davis, and Letrecia Nelson with rendering criminal assistance.
The News Tribune reports they are accused of providing Clemmons with transportation, tending his gunshot wound and lying to investigators after the Nov. 29 shooting in Parkland. All pleaded not guilty.
Two women have already been convicted of helping Clemmons and sentenced to five year in prison.
The accused getaway driver, Darcus Allen goes on trial in March on aggravated murder charges.
Clemmons was killed two days after the murders.
Information from the News Tribune.
© Copyright 2010 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.


text:
executive jobs near Martinsville, VA
Merchant Services Professional Sales Executive B2B Outside Sales (W2)NEW
Advocate Merchant Solutions- Reidsville , NC
professionals to fill our account executive outside sales positions in new ... Sales Executive Responsibilities Include: • Initiating the AdvoPay sales process by...1 day ago from ZipRecruiter
Account Executive and Publisher
Best Version Media- Eden , NC
growth last year of 280%. We have Account Executive openings located throughout the United States with territories currently being assigned in your area. The ideal candidate will...6 days ago from ZipRecruiter
Interim Executive Recruiter - Legal Industry
Slj- Eden , NC
Company Description: SLJ provides direct and interim staffing services to companies of all sizes. If you are seeking a full time position or rewarding interim project we will help...12 days ago from ZipRecruiter
Health Plan RepresentativesNEW
His Majesty- Bassett , VA
#1 Leading Health Care Provider Company is seeking Health Representatives that want to work as telecommuters. Our company has been in business for 22 great years with well over 2...1 day ago from Get Healthcare Jobs
Territory/Outside Sales RepNEW
Knight- Martinsville , VA
Job Description: We are searching for sales professionals who are: Energetic, motivated individuals looking to meet with high-end community board members and local business...2 days ago from ZipRecruiter
Telemarketing at home // NOT SALES CALLS
Business Payment Services- Reidsville , NC
Company Description: We are a fast growing Merchant Services/POS company with a back-end ranking #19 in the Inc 5,000. ZERO negative inquiries about our company. We pride...6 days ago from ZipRecruiter
Territory Sales RepNEW
Williams Avery- Eden , NC
Job Description: ?Our client is is a rapidly growing company searching for exceptional individuals who share their values and vision. With 400% growth over the past 3 years they...2 days ago from ZipRecruiter
Sales Representative
RTN- Martinsville , VA
Company Description: RTN is a fast-growing leader in grocery and dollar store advertisement sales. We offer hyper local, cost effective advertising solutions to businesses across...8 days ago from ZipRecruiter
Store Administrative AssistantNEW
Kroger Company- Rocky Mount , VA
Company Description: As the largest traditional grocery chain in the United States and one of the world's largest retailers, we employ more than 339,000 associates across 31...3 days ago from ZipRecruiter
Account ExecutiveNEW
BH Media- Martinsville , VA
a Multi-Media Advertising Sales Account Executive who is as skilled in developing existing client business as they are in prospecting and developing new business. We need a high...18 hours ago from BH Media
Sign Up for Job Alerts
- Last 24 hours
- Last 7 days
- Last 14 days
- Last 30 days


text:
East coast canada. stand up
why do Canadian rappers TALK OUTTA THIER ASS like nah DUDE you aint the HOTTEST this is my first time hearing of you.
i just gave him a chance an checkd it out flow production was clean an of quality but dude was making crazy claims that i sincerely believe he cant back up.


text: Montana News News from the state of Montana. Rep. Ripley Would Cap Coal Trust At $1Billion By Jackie Yamanaka • Feb 23, 2015 Flickr user wsilver State lawmakers are considering a proposal to ask voters to cap the Constitutionally protected Coal Tax Trust at one-billion dollars. Senate Bill 353 would divert some of coal severance tax money that goes into the trust into an account to fund infrastructure projects. Sen. Brown: Reduce Road Salt By Madelyn Beck - UM Legislative News Service • Feb 23, 2015 MT Department of Transportation On Tuesday, Montana lawmakers will hear a bill that would reduce the amount of salty road de-icers used on streets and roads. A 2010 United States Geological Survey report found that winter runoff can push significant amounts of the de-icer into streams, increasing their toxicity for fish and other aquatic life. Republican Senator Dee Brown of Hungry Horse is carrying Senate Bill 369 and says it's necessary to keep Montana water clear. Tie Vote On Death Penalty Bill By Steve Jess • Feb 23, 2015 Photosforclass.com The Montana House Monday came within one vote of approving a bill to abolish the death penalty. Helena Democrat Jenny Eck read a letter signed by 55 relatives of murder victims, urging the state to do away with capital punishment "We know that elected officials who promote the death penalty often do so with the best intentions of helping family members like us," Eck read. "We are writing to say that there are better ways to help us. The death penalty is a broken and costly system. Montana doesn't need it and victims' families like ours don't want it." Should Lawmakers Meet Every Year? By Steve Jess • Feb 23, 2015 Montana Legislature A Bozeman lawmaker wants to make big changes to the way the Montana Legislature does its work. Currently, Montana legislators have just seven weeks from the time they're elected until the legislature starts. For newcomers it means a steep learning curve. Democrat Kathleen Williams says lawmakers could do a better job if they met after the election, just long enough to break up into committees, so they could study the issues facing the state for a full year, before holding their regular session. She's sponsoring a bill to do that. Transparency For Tribal Finances On Monday's Legislative Agenda By Madelyn Beck - UM Legislative News Service • Feb 20, 2015 William Marcus Monday, Montana legislators will hear a bill to create a website so state tribal members can see the who, what, where and when of the money coming into the tribe. Republican Representative Bruce Meyers of Box Elder says it's important that Native American citizens get the same open government systems as other Montanans. "We're providing tribal members as Montana citizens transparency about budgets." Many question how much money goes to federal and state governments, worrying about corruption higher up in the chain. Flathead Water Compact Advances To Senate Floor After Contentious Debate By Steve Jess • Feb 20, 2015 The Montana Legislature took a step toward ratifying the state's final outstanding water compact this morning, with a vote in the Senate Judiciary Committee. The compact involving the federal government and the Confederated Salish and Kootenai Tribes has drawn more heated debate than any issue except perhaps Medicaid expansion. Sen. Daines Talks Logging Litigation At Missoula Roundtable By Eric Whitney • Feb 20, 2015 Courtesy photo Today in Missoula, Senator Steve Daines held the second of three meetings he's called to talk timber issues. He'll do the same in Bozeman tomorrow. The Republican Freshman Senator is calling the meetings "Timber Management Reform Roundtables," and he's invited mostly timber industry representatives to give him input on what they need to maintain or grow their operations. 'Capitol Talk': Water Rights, Dark Money, Medicaid And More By Sally Mauk • Feb 20, 2015 Eliza Wiley Listen Listening... / 11:57 'Capitol Talk': Water Rights, Dark Money, Medicaid And More From This Week At The Montana Legislature This week on "Capitol Talk": The Flathead water rights compact passes out of committee. A bill intended to "shine sunlight on dark money" is making its way through the process. Lawmakers heard testimony on one part of the GOP healthcare plan. And next Friday is the bill transmittal deadline and halfway point of the session Flathead Water Compact Faces First Committee Vote Friday By Madelyn Beck - UM Legislative News Service • Feb 19, 2015 William Marcus On Friday, the Salish-Kootenai water compact faces its first big vote. If the Senate Judiciary Committee advances the bill, it will face the anger of irrigators who say they won't get as much water. Prohibition On Federal Land Sales Dies In Committee By Madelyn Beck - UM Legislative News Service • Feb 19, 2015 Montana Legislature A bill that would ban the federal government from selling public lands died today at the Montana Legislature, mostly because opponents said it is unconstitutional. Some Days You Just Can't Win. But You Can Tie. Twice. By Steve Jess • Feb 19, 2015 William Marcus Some days you just can't win...but you can tie, twice. It happened this week at the Montana State Capitol, as Montana Public Radio's Steve Jess explains. Lawmaker Wants Limits On Solitary Confinement In Montana By Steve Jess • Feb 19, 2015 Montana Legislature A Democratic lawmaker wants to put limits on the use of solitary confinement in Montana prisons, but the warden of the men's prison says it's the only tool he has for dealing with some prisoners. Representative Jenny Eck of Helena wants to place limits on how long, and for what reasons, a prisoner can be isolated from other inmates. Weather Keeps Yellowstone Bison Harvest Numbers Below Target By Jackie Yamanaka • Feb 19, 2015 Jackie Yamanaka Another nearly 4-dozen Yellowstone National Park bison are scheduled to be loaded up today at the Stephens Creek Capture facility and delivered for slaughter in Big Timber and Columbus. It's part of the population control measures spelled out under the Interagency Bison Management Plan. Yellowstone officials held a tour of the Stephens Creek facility yesterday. Rick Wallen is the lead wildlife biologist for Yellowstone's bison program. Sen. Tester: Lawsuit Claim An 'Error' By Eric Whitney • Feb 19, 2015 courtesy photo Yesterday, in a story about attempts to boost revenue for Montana counties that are mostly federal land, Montana Senator Jon Tester made the following statement: "Unfortunately, every logging sale in Montana right now is under litigation. Every one of them." Several listeners questioned that statement, so we asked Senator Tester to respond. His communications director Marnee Banks said he is unavailable this week. Many More Montanans Buy Coverage on HealthCare.Gov By Eric Whitney • Feb 18, 2015 The deadline to buy health insurance at HealthCare.gov was Sunday, and a lot more people in Montana did that this year than did last year. "It's encouraging to us that more than 54,000 Montanans went to HealthCare.gov to purchase their health insurance," said Jesse Laslovich, chief legal counsel for Montana's insurance commissioner. That's compared to about 37,000 last year. Lawmakers Hear Testimony On Republican Medicaid Bill By Steve Jess • Feb 18, 2015 Montana Legislature Montana lawmakers took testimony Wednesday on the first of several bills designed to expand healthcare coverage in Montana without the full-scale Medicaid expansion Governor Steve Bullock is proposing. SRS Funding Bill Could Bring Relief To Montana Timber Counties By Edward O'Brien • Feb 18, 2015 Eric Whitney Montana's U.S. senators are getting behind a new bill they say will help Montana's most rural counties round-out their budgets. Mineral County Commissioner Duane Simons says communities like his are reeling after Congress failed to renew the Secure Rural Schools Act last fall. Online Privacy Bills On Thursday's Legislative Agenda By Madelyn Beck - UM Legislative News Service • Feb 18, 2015 William Marcus Thursday at the Montana Capitol, legislators will hear bills to increase Montanans' privacy on their iPads, smartphones, and even online. Bill Making 3rd DUI A Felony Dies In Committee By Madelyn Beck - UM Legislative News Service • Feb 18, 2015 Montana Legislature Wednesday, Montana legislators killed a bill that would have made a 3rd DUI offense a felony. Under current state law, the 3rd offense has a maximum sentence of one year in jail and $5,000 fine. Under the bill, this would increase to a maximum of 5 years and $10,000 fine. Legislature Debates Another Bill Criminalizing Physician Assisted Suicide By Steve Jess • Feb 18, 2015 Montana Legislature One day after the Montana House voted down a bill that would criminalize doctor-assisted suicide, another bill was introduced with the same goal. Libby Republican representative Jerry Bennett wants to change the current law against assisting a suicide, to allow doctors to be prosecuted. House Votes To Remove Restrictions On Concealed Carry By Steve Jess • Feb 18, 2015 The Montana House Wednesday approved a bill to let anyone carry a concealed weapon if they're legally eligible to own a handgun. Gun owners would no longer need to get a concealed-carry permit. Republican representative Bill Harris of Winnett said mass shootings, like the one in a Colorado theater in 2012, might not happen if more people carried concealed weapons. Sen. Daines Holds Forest Management Roundtables To Find Ways To Boost Logging By Eric Whitney • Feb 17, 2015 Eric Whitney Tuesday in Columbia Falls, Senator Steve Daines kicked off a series of three meetings in western Montana that he's calling "Forest Management Reform Roundtables." Around the table were executives from three timber mills, county commissioners from Sanders, Lincoln and Mineral counties, and Montana leaders of The Wilderness Society, The Nature Conservancy, and the National Parks Conservation Organization. House Defeats Bill Criminalizing Physician-Assisted Suicide By Jackie Yamanaka - Yellowstone Public Radio • Feb 17, 2015 William Marcus The Montana House narrowly defeated a bill that said doctors could face criminal charges for prescribing life-ending medications even if the patient made the request. Republican Medicaid Bill On Wednesday's Legislative Agenda By Madelyn Beck - UM Legislative News Service • Feb 17, 2015 William Marcus Wednesday at the Montana legislature, the Republicans lay out the start of their own version of Medicaid expansion. Republican Representative Nancy Ballance is carrying House Bill 455, which would extend state insurance coverage to people with disabilities, low-income parents and veterans. She says this would only include about 10,000 of the approximate 70,000 Montanans without insurance, because she says many of those people are "working-age adults with no kids and no disabilities." Bill Would Force Police To Prove Confiscated Assets Were Used For Crime By Madelyn Beck - UM Legislative News Service • Feb 17, 2015 Montana Legislature Today at the Montana Capitol, legislators joined the national conversation about civil asset forfeiture, or, put simply, police taking money and property before they charge someone. The bill's sponsor, Democratic Representative Kelly McCarthy, is teaming up with Republican Representative Daniel Zolnikov to promote House Bill 463, which he says would force police to prove that the assets they confiscate were used in a crime. Bill Tightens Restrictions On Asset Forfeiture By Law Enforcement By Steve Jess • Feb 17, 2015 Montana Legislature Billings Republican Daniel Zolnikov claims police are abusing laws that let them seize property from suspected drug offenders. He claims police seized $10,000 in cash from an out of state motorist pulled over for expired plates. Zolnikov says police took the money even though the man was never charged with a crime. "This, mister chairman and members of the committee, is what I would consider literal highway robbery," Zolnikov testified. He says he can't name the citizen, or the agency involved, because the case is still being litigated. Sen. Tester Backs Secure Rural Schools, PILT Funding Bill By Edward O'Brien • Feb 17, 2015 Democratic Senator Jon Tester has signed-on to a new bill that he says would bring badly-needed financial security to Montana's most rural and timber-dependent counties. Senator Tester says the "Secure Rural Schools and Payment in Lieu of Taxes Repair Act" would annually reauthorize Montana's SRS payments for three years at $23 million, the level provided in 2011. Dozens Testify At Flathead Water Compact's First Hearing By Steve Jess • Feb 16, 2015 Eric Whitney On the calendar it may have been Presidents Day, but for the Senate Judiciary Committee, Monday was no holiday. Flathead Water Compact On Monday's Legislative Agenda By Madelyn Beck - UM Legislative News Service • Feb 13, 2015 William Marcus Monday, the Montana legislature will hear the bill to pass the Salish-Kootenai water compact, essentially mapping out water rights for the Flathead reservation and surrounding area. The bill's sponsor is Republican Senator Chas Vincent of Libby, who was the compact's opposition last session. He says, even amid death threats, he believes this year's compact is better and absolutely necessary to ensure Montana keeps it's water. Montana Legislators Debate Constitutional Convention For Balanced Budget Amendment By Madelyn Beck - UM Legislative News Service • Feb 13, 2015 Montana Legislature Montana legislators disagree on whether to call for another Constitutional Convention, and it's not along party lines. Republican Representative Matthew Monforton is proposing Montana join a growing number of states, now at 24, to meet to change the United States Constitution to require Congress to balance their budget. Democratic Missoula Representatives Nate McConnell and Andrew Person are part of the committee that passed this resolution to the House floor. Though they generally agree, on this vote, they didn't. Pages« first ‹ previous … 7 8 9 10 11 12 13 14 15 … next › last »


text:
[GIF] Congo goalkeeper celebration by carboniteface in soccer
[–]rkilroysilk 247 points248 points249 points (0 children)
[Post Match Thread] Costa Rica v Greece - Round of 16 by TheNoob29 in soccer
[–]rkilroysilk 166 points167 points168 points (0 children)
Cheeky Berbatov goal from 2004 by Adrian5156 in soccer
[–]rkilroysilk 133 points134 points135 points (0 children)
Once upon a time AC Milan by rccrdc in soccer
[–]rkilroysilk 70 points71 points72 points (0 children)
So, now that CS:GO is officially an extreme sport. that means you and I are extreme athletes by in GlobalOffensive
[–]rkilroysilk 67 points68 points69 points (0 children)
Tim Howard's 16 saves are the most ever by a goalkeeper in recorded World Cup history. by urfaselol in soccer
[–]rkilroysilk 59 points60 points61 points (0 children)
If you are a Pro player or involved in casting/production, you need to read this by Luffing in GlobalOffensive
[–]rkilroysilk 64 points65 points66 points (0 children)
So, DE_TUSCAN finally (after 3 years) looks actually pretty decent and (almost) ready for competitive? by lelele66 in GlobalOffensive
[–]rkilroysilk 52 points53 points54 points (0 children)
Fun Fact... by Libaax_Jr in chelseafc
[–]rkilroysilk 54 points55 points56 points (0 children)
Just spotted this on /r/battlestations ... the HORROR! by Rainymood_XI in MechanicalKeyboards
[–]rkilroysilk 50 points51 points52 points (0 children)
Jeremy Vine hosting the BBC's european and local election coverage by mikerus in photoshopbattles
[–]rkilroysilk 43 points44 points45 points (0 children)
Sticker | Lord Gaben by hunn3r in GlobalOffensive
[–]rkilroysilk 42 points43 points44 points (0 children)
Torres loan agreed by thehandsomelyraven in soccer
[–]rkilroysilk 43 points44 points45 points (0 children)
Who do you think is the key signing of this coming season? by in chelseafc
[–]rkilroysilk 40 points41 points42 points (0 children)
CS:GO - Top 10 Highlights of DreamHack Summer 2014 by tweeday in GlobalOffensive
[–]rkilroysilk 35 points36 points37 points (0 children)
Jose says 'he will never walk away' (bbc.co.uk)
submitted by rkilroysilk to /r/chelseafc
1v3 Double Knife Clutch by Emma W by andersholmv1k in GlobalOffensive
[–]rkilroysilk 36 points37 points38 points (0 children)
All 20 Premier League Managers when they were players [Album] by domalino in soccer
[–]rkilroysilk 32 points33 points34 points (0 children)
IamA Dunkin Donuts/Baskin Robbins Employee AMA! by Carly363 in IAmA
[–]rkilroysilk 32 points33 points34 points (0 children)
"Don't be afraid to take the HARD shot." by FuryanEU in GlobalOffensive
[–]rkilroysilk 31 points32 points33 points (0 children)
A farmer from Lincolnshire visits London for the first time by bakkas in videos
Despite receiving psychiatric help in prison Charles Bronson has covered himself in Lurpack and kicked off again. I Can't Believe He's Not Better. by Tea_Total in britishproblems
[–]rkilroysilk 27 points28 points29 points (0 children)
5 small but positively impactful changes that would improve Inferno without affecting the meta game too much. by SensibleDictator in GlobalOffensive
This little gal decided to weigh in on the conversation today at work by JDsmigs in aww
The Ice bucket challenge we've all been waiting for by Haaring in chelseafc
[–]rkilroysilk 27 points28 points29 points (0 children)


text:
VIEWS: 264 PAGES: 2 CATEGORY: Business POSTED ON: 4/21/2011 Public Domain
Letter of Intent Template Non Profit document sample
OHIO DEPARTMENT OF TRANSPORTATION SPECIALIZED TRANSPORTATION PROGRAM 2011 LETTER OF INTENT FORM (Complete and submit this form) (Use arrow keys to move from blank to blank) 1. Complete the following information for your organization: Agency Name: Contact Name: Address: City, State Zip: Ohio County: Phone Number: Fax Number: Email Address: 2. What type of agency is your organization: (Check appropriate agency description) Private Non-Profit Agency Organization which serves as the lead in a current Ohio Coordination Program project A government entity which certifies that there are no nonprofit organizations readily available in the area to provide special services 3. Nonprofit agencies must verify the organization's active business status by submitting a print out of the Ohio Secretary of State's Charter/Business filing showing the expiration date of their Certificate of Continued Existence. This information may be obtained by searching the Ohio Secretary of State's website: www.sos.state.oh.us/SOS/businessServices/Nonprofit.aspx a. Search Filings a. Click on Charter/Registration Number b. Enter your Charter/Registration Number Charter Number Expiration Date c. Print out the resulting page and submit with your Letter of Intent. A sample copy of the form is attached. (Do not submit Articles of Incorporation) d. This is the only document to be submitted with the Letter of Intent. 4. What geographic area (city, county(ies)) does your organization serve? (Origination of trips) 5. How does your agency serve the transportation needs of the elderly and disabled in your area? 6. Describe any transportation coordination efforts in which you are currently participating. Be specific and concise. 7. Projects to be submitted for the program must be derived from a Locally Developed Coordinated Public Transit-Human Services Transportation Plan (Coordinated Plan). a. What is the name of the Coordinated Plan for your area? b. Who is the lead agency for the plan? c. What date was the plan adopted? d. Was the plan submitted to ODOT? If yes, when? 8. What vehicle(s)/equipment will your agency apply for? Briefly describe how the vehicle/equipment will be used. 9. What is the source of the local share for the project? Will these funds be available July 1, 2011? Submit Letter of Intent Electronically to: Or Mail to: E-mail: email@example.com Marianne E. Freed Ohio Department of Transportation Fax: (614) 887-4174. 1980 West Broad Street Columbus, OH 43223 Applications for the Specialized Transportation Program will be sent electronically to those organizations which qualify for the program based on the above questions. If you do not have e-mail, your application will be sent via U.S. Mail. Questions should be directed to the e-mail address listed above. DEADLINE FOR LETTER OF INTENT: November 30, 2010 (Extended from November 22, 2010) (e-mail, fax or postmark date) Letter of Intent responses must be no more than 3 pages.
Pages to are hidden for
"Letter of Intent Template Non Profit"Please download to view full document