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Kukla's Korner Hockey
Off-Season Game Plan: Chicago Blackhawks
by Tony on 06/19/10 at 11:45 AM ET
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From TSN's Scott Cullen:
The Chicago Blackhawks won the Stanley Cup for the first time since 1961, so it's a summer for celebrating. For some, notably GM Stan Bowman, it's going to be a summer involving tough decisions as the Blackhawks scramble to get under the salary cap.
Off-Season Game Plan looks at the championship roster and what the Blackhawks can do if they're going to have a legitimate chance to defend their title.
Such is the nature of the salary cap world in the NHL that great young teams face a tight window of opportunity because it's so difficult to keep an entire team together.
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Tags: chicago+blackhawks, nhl-hockey
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Tayous Sign Pro Contracts
MORGANTOWN, W.Va. - Former West Virginia University men's soccer player's Franck Tayou and Uzi Tayou have signed with the Las Vegas Legends of the Professional Arena Soccer League (PASL).
Franck Tayou was a two-year letterwinner from 2010-11 as a forward, finishing with nine goals and one assist in 39 matches. Tayou led WVU in goals (9) and game-winning goals (5) during the 2010 season.
Uzi Tayou played in 36 career games from 2010-11, starting 21 matches in 2010. He registered two goals and one assist as a center back along the backline.
The PASL consists of 16 teams in the United States and one team in Mexico after the addition of six expansion teams for the 2012-13 season.
Big 12 Championship Update No. 3
Big 12 Championship Update No. 2
Big 12 Championship Update No. 1
Baseball: Big 12 Championship
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subset: commoncrawl


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Hotel Alisei
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La Residencia del Paseo
"We have been there just before high season started, so we could enjoy this place nearly empty and for very good price. We liked bar at pool, for good and not expensive food and nice people. Recepcionists were always helpful and welcomed. Room was very nice, spacious, with hot water, TV, fast Internet (on balcony). Just be prepared for mosquitos at night. It is in very good location of Las Terrenas, just few metres from beach and also main street and nightlife. We enjoyed our stay very much!"
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Yelling at children won't help them learn, grow
Yelling at your children when things go wrong isn't going to help them, according to an article by The Wall Street Journal. Research showed that 75 percent of parents yell at their children, and this can be dangerous for a child's ability to grow, the WSJ reported. While talking sternly and authoritatively is fine, "yelling becomes damaging when it is a personal attack, belittling or blaming a child," the WSJ said.
"Many parents lose control because they take children's misbehavior or rebellion personally, research shows: They feel attacked or think the child's actions reflect poorly on them," the WSJ reported.
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Cactuar's Desert Prison, submitted by Retekin. God awful Final Fantasy fanfic and art mix in a heady brew on this oddly Cactuar themed web site. Be sure to note their touching tribute to the World Trade Center attack.
Zack approached the bed, his eyes never leaving Sephiroth's magnificent torso. How long had he wanted this man? Forever, it seemed. Since he'd first seen him. To be trained by him had been a pleasure; to watch Sephiroth's glorious form swinging his sword and moving with the grace of a thousand dancers. The fact that the great fighter seemed vulnerable at this moment only heightened Zack's attraction to him. He'd always liked being in charge - especially sexually - and the vibes he was receiving from Sephiroth now told him his dream was going to be more than fulfilled. He knew Sephiroth was all work; all training. He'd never heard of the man going out with anyone. Maybe he was a virgin. Maybe the teacher was about to get a lesson.
Zack's eyes finally moved up to Sephiroth's beautiful green ones and he saw the lust coupled with the uncertainty in them. That look told Zack his suspicions were correct. Sephiroth was virgin territory.
WHAT?! Zack?! Who the...GODDAMMIT! I admit Sephiroth has some kissable lips, and I've had a fantasy or two, but I HAVE NEVER SLEPT WITH HIM! Fuuuuuuuuck.
PS - Be sure to voice my intense gratitude over their use of my name in their wonderful Guestbook!
it's hard to shake the feeling that I've always got five stars in this Grand Theft Auto known as life.
Now, inexplicably, season three is looming over us like some sort of dome. Season one's plot asked whether or not the town could get out from under the dome. Apparently the answer was "no". Season two asked "I guess we're really stuck, huh?" and the answer was "yup".
A Goon from the future hands out cool names and shares facts about the post-apocalyptic lifestyle!
Haymaker and the Vein return to bring us the new sport of Extreme Cave Monster Death Spelunking!
Meet the exciting new Goon-approved presidential candidate!
Awful Links of the Day spotlights the worst and weirdest websites on the internet. And we're not talking "weird" in a good way either.
Copyright ©2015 Rich "Lowtax" Kyanka & Something Awful LLC.


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University of Cambridge > Talks.cam > CMS Electricity Usage 10-10 > CMS electricity usage: 10149.5 kWh on 12/11/12
CMS electricity usage: 10149.5 kWh on 12/11/12
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If you have a question about this talk, please contact Dankrad Feist.
This talk is part of the CMS Electricity Usage 10-10 series.
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Other listsjer64's list Special Lecture Series: THE NATURAL COOK: A THEORY OF HUMAN EVOLUTION World History Workshop
Other talksStem cells: from basic research to bioprocessing Antibiotic resistance and antibiotic alternatives: Looking towards the future A KPZ formula for SLE and Brownian motion Spectacular Chemistry Demonstration Lecture Transport Scotland 'Why is patient safety so hard?'


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Former Pakistan leader Musharraf indicted for high treason
Landmark case marks a sharp blow to the previously untouchable military in Pakistan.
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ISLAMABAD — A special Pakistani court on Monday indicted former military ruler Pervez Musharraf on five counts of high treason, a charge that potentially carries the death penalty and comes as a sharp blow to the country's powerful military.
The development is the first time that an acting or former army chief has been indicted for treason in Pakistan, where the military has taken power in three coups since the country was founded in 1947.
The indictment — the latest high drama in a series of legal cases Musharraf has faced since returning to Pakistan a little over a year ago — also showcases the tensions between a civilian government that initiated the case and the military, which has generally been above the law.
Musharraf, who appeared in court on Monday for only the second time in the lengthy court proceedings that began in December, pleaded not guilty to all five counts and delivered a nearly 30-minute defence of his time in office.
The former general, who has been at a hospital in the nearby city of Rawalpindi after complaining of chest pains on his way to a court session in January, said he was appearing in the proceeding against the advice of his medical team.
The judges in the case were expected to rule Monday on a defence motion to allow Musharraf to leave the country to see his ailing mother in Dubai, in a development that could see the former military ruler leave the country. The three-judge tribunal was constituted just to deal with the treason case.
"I am being called a traitor," he said. "I put the country on the path of progress after 1999 when the country was being called a failed and a defaulted state."
"Is this the way to reward someone for being loyal to the country and for loving the country?" Musharraf asked the court.
If convicted, Musharraf could face the death penalty but it remains unclear whether the trial will ever get that far. Musharraf's lawyers have been requesting that he be allowed to leave the country for medical treatment.
On Monday, his lawyer Farogh Naseem again requested that Musharraf be allowed to leave Pakistan, this time to visit his mother.
"The mother is dying, for God's sake," said Naseem. "He will come back. He wants to face the trial. He wants his name to be cleared."
The prosecutor, Akram Sheikh, expressed sympathy for Musharraf, and while he didn't say whether the former military ruler should be allowed to leave the country, he didn't object either.
After the proceedings were finished, the prosecutor, who has often been part of testy exchanges between the prosecution and defence, walked up to Musharraf, greeted him warmly and the two chatted briefly as dozens of security personnel, lawyers and journalists looked on.
The indictment had been expected back in December when the court first met at the National Library that has served as a courtroom for the high-profile trial. But Musharraf repeatedly failed to appear in court — first due to security concerns and then due to the health scare — leading to speculation that he was trying to avoid the embarrassing experience of subjecting himself to a civilian court.
Musharraf finally appeared in court on Feb. 18 but was not indicted because the judges decided to rule on a defence challenge to whether they had jurisdiction in the case or not. Once that was settled the judges pushed to have Musharraf appear in court so the charges could be read and the trial proceed, even issuing an arrest warrant requiring he be in attendance on Monday.
Security was tight Monday. All traffic near the courtroom was shut down to allow Musharraf's convoy to travel. Paramilitary Rangers and police took up positions inside the courtroom.
Musharraf's rush to a military hospital in early January sparked speculation that the military was moving to protect him and that he would soon leave the country under guise of receiving medical treatment.
Musharraf took power in a 1999 coup but was forced to step down in 2008. The high treason case stems from his decision to suspend the constitution on Nov. 3 2007 and detain a number of judges. The move backfired and led to widespread protests by the country's powerful legal community. Eventually, Musharraf stepped down and left the country.
Musharraf said Monday that he did not subvert the constitution and that his actions had been taken on the advice of the prime minister and the cabinet.
He returned to Pakistan last March with the hope of running in the national election held in May. But he was disqualified and has spent most of his time since battling legal cases.
The other cases facing Musharraf involve his alleged role in the murder of former Pakistani Prime Minister Benazir Bhutto, the death of a Baluch separatist leader killed by the army, the killing of a radical cleric and the detention of Pakistani judges. But the treason case is by far the most serious.
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text:
Written on: 22/01/2013 by cheshirecat69 (1 review written)
I hadn't heard of Concord Extra before but found them on a comparison website looking for womens winter fleeces and tops at a reasonable price. Their selection seemed current and favourable so I decided to try them and ordered a couple of items. Concord sent me clear information re my order and processing and the items arrived within 48 hrs, well packaged and exactly what I wanted. Will definitely consider them again.
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It was a steamy three-hour meeting last night near Garrison, where DNR officials met with local Lake Mille Lacs business owners, guides and residents to talk about possible regulations needed to reduce the walleye harvest on the lake.
See my story elsewhere on this page for details.
"This is probably the most important lake in the state,'' DNR fisheries chief Dirk Peterson told the group of 60 that jammed into the Hazleton Town Hall. "We want it to remain THE walleye lake in Minnesota.''
But members of the Mille Lacs Fishery Input Group clearly were frustrated with the situation they face: Telling customers there likely will be a 2-inch harvest slot for walleyes, and two-fish bag limit to begin the season.
Meanwhile, the DNR announced today that it will take additional comments on its Mille Lacs fishing regulation proposals by email at firstname.lastname@example.com.
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Hunters being asked to submit wild turkeys for avian flu testing
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Nearly 6-pound fish sets new state record


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What's blooming now at Southwick Beach State Park.
The Daily Bucket is a place where we post and exchange our observations about what is happening in the natural world in our neighborhoods. Birds, blooms, bugs & more - each note is a record that we can refer to in the future as we try to understand the patterns that are quietly unwinding around us.July 2, 2013
Here's some photos I took this morning on my walk down the beach to the park.
Common Milkweed - it may be common but I love it.
Swamp milkweed - these grow way down in our bit of swamp behind the dunes but this one found a spot right next to a park-mowed field along the road in.
Unknown plant, some kind of aster. The spiky seedpod caught my eye,
Other beach diaries:
Cool Clouds
Wetlands behind the dunes
Sandy Beaches, Blue Skies
A quick bucket for the day - I never tire of wildflowers. The more I see and learn about them, the more I enjoy them.
And The Daily Bucket is now open for your thoughts and observations
"Green Diary Rescue" is Back!
After a hiatus of over 1 1/2 years, Meteor Blades has revived his excellent series. As MB explained, this weekly diary is a "round-up with excerpts and links... of the hard work so many Kossacks put into bringing matters of environmental concern to the community... I'll be starting out with some commentary of my own on an issue related to the environment, a word I take in its broadest meaning."
"Green Diary Rescue" will be posted every Saturday at 1:00 pm Pacific Time on the Daily Kos front page.


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Town Square
BattleStar Galactica Comes to Palo Alto
Original post made by So Say We All, Greenmeadow, on May 28, 2008
7:30pm on Tue., June 3, Rabbi Ari Cartun will present a talk and lead a discussion among BSG fans.
For more info, see Web Link
Comments (3)
a resident of Palo Alto High School
on May 28, 2008 at 5:19 pm
LMAO. Reminds me of the Matrix books on philosophy.
There are other important themes in BSG as well, like political ones which are just as interesting.
a resident of Crescent Park
on May 28, 2008 at 8:51 pm
Knowing Ari, he won't shy away from the political topics either. He is an amazing presenter too. It should be interesting!
a resident of Midtown
on May 30, 2008 at 8:06 am
The explosion of nuclear wastes that threw the moon out of orbit, and the lights around the pilot helmets that illuminated the actor faces but would have killed any night vision, and the androids with their oscilating red eye - camp before it really got going. The cigar smoking was an interesting anachronism, though.
Don't miss out on the discussion!
Sign up to be notified of new comments on this topic.
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Download the Free Unbound MEDLINE PubMed App to your smartphone or tablet.
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TMP [keywords]
4186 results
- Tetramethylpyrazine inhibits CTGF and Smad2/3 expression and proliferation of hepatic stellate cells. [JOURNAL ARTICLE]
- Biotechnol Biotechnol Equip 2015 Jan 2; 29(1):124-131.
To study the effects of tetramethylpyrazine (TMP) on the proliferation of hepatic stellate cells-T6 (HSC-T6), and the expression of connective tissue growth factor (CTGF) and Smad2/3 in these cells, HSC-T6 cells were cultured with TMP at different concentrations after transforming growth factor-β1 (TGF-β1) stimulation. MTT assay was used to assess the cell proliferation. Cells were divided into the control group, TGF-β1-treated group and TMP-treated groups, which were treated with different concentrations of TMP. Immunocytochemistry and western blot were performed to detect the expression levels of CTGF and Smad2/3 in HSC-T6 cells. MTT analysis indicated that TMP significantly inhibited the proliferation of HSC-T6 cells, in dose-dependent and time-dependent manners. Immunocytochemistry detection and western blot showed that TMP could diminish TGF-β1-induced CTGF over-expression in HSC-T6 cells. Similarly, the enhancing effects of TGF-β1 on Smad2/3 expressions in HSC-T6 cells could also be counteracted by TMP treatment. Nuclear translocation of Smad2/3 was blocked by TMP treatment. Correlation analysis suggested a positive correlation between CTGF and Smad2/3 expression levels in HSC-T6 cells. TMP exerts anti-hepatic fibrosis effect through decreasing the expression of CTGF and Smad2/3, as well as inhibiting the proliferation of HSC-T6 cells. Our study provides cellular and molecular bases for further application of TMP in the clinical treatment for hepatic fibrosis.
- Screening bioactive compounds from Ligusticum chuanxiong by high density immobilized human umbilical vein endothelial cells. [JOURNAL ARTICLE]
- Anal Bioanal Chem 2015 May 28.
High throughput screening methodologies play a very important role in screening bioactive compounds from complex media. In this work, a new strategy for attaching cells onto amino microspheres using human umbilical vein endothelial cells (HUVECs) as a probe was developed. The immobilization depended on the specific affinity between integrin on the cells and the RGD peptide, which was coated on poly[oligo (ethylene glycol) methacrylate] by atom transfer radical polymerization. Validated application of the stationary phase was performed in the analysis of Ligusticum chuanxiong extraction by high performance affinity chromatography-mass spectrometry. Three compounds were screened as the bioactive compounds of Ligusticum chuanxiong. Two of them were identified as 3-butyl-hexahydroisobenzofuran-1(3H)-one and tetramethylpyrazine (TMP), whereas the other one remains indistinct. The association constant of vascular endothelial growth factor (VEGF) and TMP binding to VEGF receptor (VEGFR) on HUVECs were calculated to be (1.04 ± 0.08) × 10(11) M(-1) and (9.84 ± 1.11) × 10(8) M(-1) by zonal elution. Molecular docking showed that one hydrogen bond was formed between N atom of TMP and 3-N atom of imidazole group in histidine(223) of VEGFR. Both zonal elution and molecular docking indicated that TMP and VEGF bind to the same site of VEGFR on HUVECs. It is possible to become a promising tool for high throughput screening of the bioactive compounds binding to HUVECs through broad application of the stationary phase.
- Reactivity of Amine/E(C6F5)3 (E = B, Al) Lewis Pairs toward Linear and Cyclic Acrylic Monomers: Hydrogenation vs. Polymerization. [Journal Article]
- Molecules 2015; 20(6):9575-90.
This work reveals the contrasting reactivity of amine/E(C6F5)3 (E = B, Al) Lewis pairs toward linear and cyclic acrylic monomers, methyl methacrylate (MMA) and biorenewable γ-methyl-α-methylene-γ-butyrolactone (γMMBL). While mixing of 2,2,6,6-tetramethylpiperidine (TMP) and B(C6F5)3 leads to a frustrated Lewis pair (FLP), Et3N reacts with B(C6F5)3 to form disproportionation products, ammonium hydridoborate ionic pair and iminium zwitterion. On the other hand, the stoichiometric reaction of either TMP or Et3N with Al(C6F5)3 leads to clean formation of a classic Lewis adduct (CLA). Neither TMP nor Et3N, when paired with E(C6F5)3, polymerizes MMA, but the Et3N/2B(C6F5)3 pair promotes transfer hydrogenation of MMA to form methyl isobutyrate. In contrast, the amine/E(C6F5)3 pairs promote rapid polymerization of γMMBL carrying the more reactive exocyclic methylene moiety, achieving full conversion in less than 3 min even at a low catalyst loading of 0.0625 mol %. TMP is more effective than Et3N for the polymerization when paired with either the borane or the alane, while the alane exhibits higher polymerization activity than the borane when paired with Et3N. Overall, the TMP/Al(C6F5)3 system exhibits the highest polymerization activity, achieving a maximum turn-over frequency of 96,000 h-1 at 0.125 mol % of catalyst loading, producing high molecular weight PγMMBL with Mn = 1.29 × 105 g∙mol-1.
- Stenotrophomonas maltophilia keratitis treated with trimethoprim-sulfamethoxazole. [JOURNAL ARTICLE]
- Arch Soc Esp Oftalmol 2015 May 22.
- AbstractPublisher Full TextPublisher Full Text
An 84 year-old woman with persistent epithelial defect and a dense stromal infiltrate post-corneal transplantation. According to the microbiological results, it was due to a Stenotrophomonas maltophilia (S. maltophilia) resistant to all antibiotics except trimethoprim-sulfamethoxazole (TMP/SMX). Healing was achieved after three weeks of treatment with oral and topical TMP/SMX.S. maltophilia is an opportunistic microorganism rarely described in ophthalmology. It is associated with conjunctivitis, keratitis, scleritis, dacryrocystitis, cellulitis, and endophthalmitis with significant morbidity. Treatment is complicated because of its resistances to broad-spectrum antibiotics. TMP/SMX monotherapy can be considered an option of treatment for this type of keratitis.
- Reentrant Origami-Based Metamaterials with Negative Poisson's Ratio and Bistability. [JOURNAL ARTICLE]
- Phys Rev Lett 2015 May 8; 114(18):185502.
- AbstractPublisher Full Text
We investigate the unique mechanical properties of reentrant 3D origami structures based on the Tachi-Miura polyhedron (TMP). We explore the potential usage as mechanical metamaterials that exhibit tunable negative Poisson's ratio and structural bistability simultaneously. We show analytically and experimentally that the Poisson's ratio changes from positive to negative and vice versa during its folding motion. In addition, we verify the bistable mechanism of the reentrant 3D TMP under rigid origami configurations without relying on the buckling motions of planar origami surfaces. This study forms a foundation in designing and constructing TMP-based metamaterials in the form of bellowslike structures for engineering applications.
- Bone marrow suppression and associated consequences in patients after heart transplantation: A 6-year retrospective review. [JOURNAL ARTICLE]
- Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2015 May 14.
- AbstractPublisher Full Text
To evaluate the incidence of bone marrow suppression and consequences of MMF dose adjustment in patients within the first year after heart transplantation.Group I (n=47) was treated with a regimen currently used in patients after heart transplantation (mycophenolatemofetil - MMF, valganciclovir - VGC and trimethoprim/sulfamethoxazole - TMP-SMX). Group II (n=47) received only MMF of potentially myelotoxic medications. The myelotoxic effect and need for dose modification were assessed. The incidence of rejections and infectious episodes associated with MMF adjustment were analyzed during the first 12 months in Group I.There was a significantly greater proportion of patients with leukopenia (leukocyte count < 4 x 10^9/L) at 3 months after orthotopic heart transplantation in Group I compared with Group II (19.1% vs 2.1%; P = 0.02). The difference in lymphopenia (lymphocyte count < 0.8 x 10^9/L) at 3 months follow-up was highly significant (38.3 % vs 6.4 %; P = 0.0002). MMF was modified due to bone marrow suppression or severe infection in 63.8% patients in Group I and in only 8.5% of patients in Group II (P < 0.001). Reducing or stopping MMF was not associated with increased rejections. In Group I, at least 1 episode of higher degree cellular or humoral rejection occurred in 35% of patients with the standard MMF dosage compared with only 26% in patients with modified MMF (P = 0.0534).Addition of VGC+TMP-SMX to current immunosuppressive medication regimen in patients after heart transplantation is associated with significant lymphocytopenia and leukopenia. Importantly, modification of immunosuppressive prophylaxis (reducing or stopping MMF) leads to normalization of blood count without increased incidence of rejections.
- Membrane photoreactor treatment of 1,4-dioxane-containing textile wastewater effluent: Performance, modeling, and fouling control. [JOURNAL ARTICLE]
- Water Res 2015 May 10.
- AbstractPublisher Full Text
A membrane photoreactor (MPR) system was investigated for the purification of textile wastewater effluent containing 1,4-dioxane for potential reuse. The effects of TiO2 dosage, alkalinity, particulate matter, and sunlight radiation on the removal of 1,4-dioxane from the effluent were evaluated. The photocatalytic 1,4-dioxane degradation followed pseudo-first order reaction kinetics. A considerably large dose of TiO2 catalyst (5 g/L) was required for maximal 1,4-dioxane degradation by MPR. The high alkalinity (∼550 mg/L) of the textile wastewater effluent negatively affected the 1,4-dioxane degradation rate, whereas 1,4-dioxane degradation was not impacted by the presence of particulate matter. Solar photocatalysis of 1,4-dioxane was as effective as that achieved with UV lamps in the MPR, which could lead to energy savings. Continuous flow MPR was effective for continuous degradation of 1,4-dioxane; the unsteady- and steady-state performances were well-predicted at various hydraulic residence times (HRTs). The quality of the MPR product obtained at an HRT of 8.57 h satisfied the drinking water guidelines. The transmembrane pressure (TMP) buildup, which is indicative of fouling, was dependent on the TiO2 dose and permeate flux. The TMP buildup was marginal at low flux, but increased dramatically beyond a flux level of >60 L/m(2)-h. However, the fouling layer could be sufficiently removed by periodic backwashing, even at an extremely high flux of 100 L/m(2)-h. The membrane permeability was sustained without any sign of irreversible fouling during MPR treatment of textile wastewater effluents.
- Multimodal distribution of human cold pain thresholds. [Journal Article]
- PLoS One 2015; 10(5):e0125822.
- AbstractPublisher Full Text
It is assumed that different pain phenotypes are based on varying molecular pathomechanisms. Distinct ion channels seem to be associated with the perception of cold pain, in particular TRPM8 and TRPA1 have been highlighted previously. The present study analyzed the distribution of cold pain thresholds with focus at describing the multimodality based on the hypothesis that it reflects a contribution of distinct ion channels.Cold pain thresholds (CPT) were available from 329 healthy volunteers (aged 18 - 37 years; 159 men) enrolled in previous studies. The distribution of the pooled and log-transformed threshold data was described using a kernel density estimation (Pareto Density Estimation (PDE)) and subsequently, the log data was modeled as a mixture of Gaussian distributions using the expectation maximization (EM) algorithm to optimize the fit.CPTs were clearly multi-modally distributed. Fitting a Gaussian Mixture Model (GMM) to the log-transformed threshold data revealed that the best fit is obtained when applying a three-model distribution pattern. The modes of the identified three Gaussian distributions, retransformed from the log domain to the mean stimulation temperatures at which the subjects had indicated pain thresholds, were obtained at 23.7 °C, 13.2 °C and 1.5 °C for Gaussian #1, #2 and #3, respectively.The localization of the first and second Gaussians was interpreted as reflecting the contribution of two different cold sensors. From the calculated localization of the modes of the first two Gaussians, the hypothesis of an involvement of TRPM8, sensing temperatures from 25 - 24 °C, and TRPA1, sensing cold from 17 °C can be derived. In that case, subjects belonging to either Gaussian would possess a dominance of the one or the other receptor at the skin area where the cold stimuli had been applied. The findings therefore support a suitability of complex analytical approaches to detect mechanistically determined patterns from pain phenotype data.
- Cross-reactivity between darunavir and trimethoprim-sulfamethoxazole in HIV-infected patients. [Journal Article]
- AIDS 2015 Apr 24; 29(7):785-91.
- AbstractPublisher Full Text
Both darunavir (DRV) and trimethoprim-sulfamethoxazole (TMP-SMX) carry a sulfonamide moiety and a warning for this cross-reactivity is given in the label of DRV. The aim of this study was to investigate the potential cross-reactivity between both drugs.Retrospective cohort study with a nested case-control study.HIV-infected patients that received DRV-containing antiretroviral therapy at any time during the period of their HIV infection were included. Patients with no history of TMP-SMX use were excluded. The incidence of a DRV allergy, according to the Naranjo probability scale, was investigated in patients with an allergy to TMP-SMX compared with those without such an allergy. In order to identify possible risk factors associated with a DRV allergy among patients allergic to TMP-SMX, a nested case-control study was subsequently performed.A total of 405 patients were included, of whom 79 (17.5%) had a history of allergy to TMP-SMX. A DRV allergy was seen in four patients (5.1%) with a TMP-SMX allergy compared with four (1.2%) without a TMP-SMX allergy (P = 0.05). Patients with a TMP-SMX allergy were at higher risk for a DRV allergy (odds ratio 4.29; 95% confidence interval, 1.05-17.56). No additional risk factors for a DRV allergy among patients allergic to TMP-SMX were identified in the nested case-control study.Although DRV allergy is uncommon, making cross-reactivity with TMP-SMX a rare clinical problem, it appears to exist more often in the background of a TMP-SMX allergy.
- Successful treatment of multifoci nocardial brain abscesses: a case report and literature review. [Journal Article]
- J Pediatr Gastroenterol Nutr 2015 May; 94(19):1-4.
- AbstractPublisher Full Text
Brain nocardiosis is a serious opportunistic infection with high mortality. It exists more common in the immunocompromised hosts than the immunocompetent patients. Trimethoprim-sulfamethoxazole (TMP-SMZ) has been mostly considered as the choice of the medical treatment. Linezolid is also newly found to be effective to avoid the invasive surgery. The authors reported a case of patient with multifoci nocardial brain abscesses who failed with the combination of linezolid and TMP-SMZ alone but recovered with the surgery intervention and sequential antibiotics for 2 years. The patient lived a high quality life without recurrence and complications during the 30 months follow-up.Through the literature review, we recommend earlier stereotactic aspiration for diagnosis, combination with surgery intervention and prolonged anti-infection therapy would improve the prognosis.


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Comments about 'Obama: Congress should vote on jobs bill in Oct.'
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Have you SEEN the Republican House on jobs?
*'Republicans kill Senate jobless aid measure' - By Andrew Taylor - AP - Published by DSNews - 06/24/10
*'Senate Republicans - again - kill bill for jobless aid' - By Stephen Ohlemacher - AP - Published by DSNews - 06/30/10
(After 2010 Midterms)
*House GOP blocks bill to extend jobless benefits By Andrew Taylor AP 11/18/10
Ok. No unemployment.
How about private jobs?
*Republicans block small business lending bill' - By Stephen Ohlemacher - AP - Published by DSNews - 07/29/10
'The bill would create a $30 billion government fund to help community banks increase lending to small businesses...'
Ok. No support for PRIVATE jobs.
How about goverment jobs?
*John Boehner: If GOP Cuts Cause Federal Job Losses...'So Be It' - Huffington Post - 02/15/11
US budget?
*'Republicans bail on budget talks, blame Democrats' - By David Espo - AP - Published by DSNews - 06/23/11
*GOP Senate hopefuls praised for 'no'...on debt bill' - By Josh Loftin, Associated Press- Published by DSNews - 08/11/11
Two months later...
*'S&P warns it may downgrade U.S. credit rating' - By Martin Crutsinger - AP - Published by DSNews - 07/15/11
The US credit score....drops.
- 1:50 p.m. Oct. 3, 2011
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Re: Pagan | 1:50 p.m. Oct. 3, 2011
Do you want to know what Obama's strategists are telling him? James Carville has just one word of advice for President Barack Obama: Panic.
Democratic Senators are the ones spoiling Obama's party. They aren't about to tax anybody, including the rich, with the 2012 election a little over a year away. You can blame the Republicans all you want but it is the Democrats that have their foot on the brake.
Meantime I'll second what James Carville is telling Obama. Time to panic Mr. President.
- 2:20 p.m. Oct. 3, 2011
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Re: Pagen | 2:49 p.m. Oct. 3, 2011
First Google 'James Carville panic'
"Democrats were in open revolt .... Democrats in the House and Senate stand for re-election in just 13 months, and their campaigns will be difficult enough without raising taxes just before voters go to the polls. Said a blunt Mr. Durbin: There are some senators who are up for election who say Im never gonna vote for a tax increase while Im up for election, even on the wealthiest people. - By Joseph Curl-The Washington Times Sunday, October 2, 2011
Read it and weep.
- 5:49 a.m. Oct. 4, 2011
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Re: Pagen | 9:36 a.m. Oct. 4, 2011
"More aides leave Bachmann presidential campaign"
I thought that was good news and was happy to read about it. I put her in the same box with 'what's his name' Jon Huntsman. Neither of them every had a chance. My personal current pick is Texas Gov. Rick Perry. He's not perfect but then again neither is Obama.
- 10:13 a.m. Oct. 4, 2011
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Re: Pagen | 9:36 a.m. Oct. 4, 2011
For what it's worth I'm truly sorry for personal attacks I've made on you in the past. Please accept my sincere apologies. Yes, we are on different sides of the political fence but that doesn't excuse nasty rude comments on my part.
I sincerely wish our leaders would band together in friendship to solve the problems that inflicting such wounds to our country. Sadly I can't imagine that happening.
- 10:20 a.m. Oct. 4, 2011
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Should children be coddled in bubble wrap and protected from every bump and scrape? Or, should children be allowed to climb Mt. Everest or sail around the world solo?
Jordan Romero was 13-years-old when he climbed to the top of Mt. Everest. Jessica Watson was 16-years-old when she sailed around the world by herself. Peter Lenz was 13-years-old when he fell of his motorcycle at the U.S. Grand Prix Racers Union, and was run over and killed by another 12-year-old driver.
Children are no longer satisfied with riding their skateboards and bikes down the steep hill in front of their house. They're doing extreme sports, skateboarding down nine story ramps or diving off of 10-meter high platforms.
Is it legal to allow children to do extreme sports?


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Jul 2, 2013; Minneapolis, MN, USA; Minnesota Twins starting pitcher Samuel Deduno (21) pauses before throwing out the first pitch against the New York Yankees at Target Field. Mandatory Credit: Jesse Johnson-USA TODAY Sports
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What does "GPL" stand for? (#WhatDoesGPLStandFor) "GPL" stands for "General Public License". The most widespread such license is the GNU General Public ... - read more
Date of Issue: July 2013 Affected Publication: API Standard 650, Welded Tanks for Oil Storage, Twelfth Edition, March 2013 ERRATA This errata corrects editorial ... - read more
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Latest Medical classification Stories
Career Step is pleased to announce that its Professional Medical Coding and Billing curriculum is on track to have students prepared for the newly announced October 1, 2015 ICD-10 implementation
Leading Pediatric Hospital Automates Professional and Technical Coding 15-months Ahead of ICD-10 Compliance Date BOSTON, Aug.
Despite lost momentum, 51 percent of US hospitals report they will be ready to implement ICD-10 with coding education, IT solutions, managed services partners, staff training and physician cooperation.
CHE Trinity Health announced today that it is actively and aggressively recruiting experienced ICD-9 coding professionals to support its transition to ICD-10 and beyond. Livonia,
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- Stoppage; cessation (of labor).
- A standing still or idling (of mills, factories, etc.).


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Castro's dream for Cuba's artists
Jigme Sherpa brings hope to Nepal's quake victims
17 Aug 2013 18:57 GMT | Sport, Football, United Kingdom
On Friday, Arsene Wenger told Arsenal fans not to worry about the club's lack of signings.
On Saturday, his team did little to reassure fans after a worrying 3-1 defeat to Aston Villa.
If the pressure wasn't on before, it is now, and Wenger may well have to pull the cheque book out soon if he is to keep fans on his side.
"We start a new season with a defeat at home... It's a massive blow," Wenger said after his team were booed off the pitch by their own fans.
"We want our fans to be happy. When you don't achieve that, you feel absolutely sorry and disappointment."
It was a positive start for the Gunners with Olivier Giroud scoring in the sixth minute, tapping in a pinpoint cross from Alex Oxlade-Chamberlain from close range.
But the damage came from the penalty spot and from one man in particular. Christian Benteke scored from two penalties to direct the spotlight back onto Wenger. Benteke equalised in the 22nd, heading in his own rebound after his penalty was saved by Wojciech Szczesny.
Saturday August 17 Liverpool 1-0 Stoke Arsenal 1-3 Aston Villa West Ham 2-0 Cardiff Norwich 2-2 Everton Sunderland 0-1 Fulham West Brom 0-1 Soton Swansea 1-4 Man Utd
The striker then slotted in a second penalty in the 61st. To add to Wenger's woes defender Laurent Koscielny was sent off for a second booking and Villa hit the Gunners with a quick counter attack late on, with new signing Antonio Luna securing the win by slotting a shot past Szczesny.
In the early kick-off, Liverpool started their English Premier League campaign with a 1-0 victory over Stoke.
Joe Cole and Kevin Nolan scored for West Ham in a 2-0 win over newly promoted Cardiff in the opening round.Cole opened the scoring after 13 minutes at Upton Park, receiving a pass from Matt Jarvis on the left before shooting low past goalkeeper David Marshall.Nolan secured the win in the 76th minute, with the West Ham captain finding the net after Mark Noble had broken into the penalty area.
Just three days after scoring the winner on his England debut, Rickie Lambert scored from the penalty spot in the last minute to give Southampton a 1-0 winning start against West Bromwich Albion.
Southampton had come closest to scoring in a game that looked set to finish goalless before the penalty, when captain Adam Lallana had a goal disallowed for offside.West Brom came close to scoring in the first half when midfielder Graham Dorrans shot narrowly over from a free kick.
Dutch debutant
Norwich City's record signing Ricky van Wolfswinkel marked his Premier League debut with a goal to earn his new side a 2-2 draw at home to Everton.The 24-year-old Dutch striker, an $13.3 million signing from Sporting Lisbon, scored with a 71st-minute header to earn Chris Hughton's side a point after Everton came from behind to lead.His goal prevented Roberto Martinez from enjoying victory in his first competitive game as Everton manager, after he succeeded the Manchester United-bound David Moyes during the close season.Goals from Ross Barkley and Seamus Coleman had turned the game in Everton's favour after Steven Whittaker gave Norwich a 51st-minute lead, only for Van Wolfswinkel to steal the show.
At Sunderland, Pajtim Kasami headed in a second-half winner to give Fulham a 1-0 victory.Sasami met a corner from Damien Duff at the far post in the 52nd to nod home his first goal for the club and frustrate the home side, which had dominated most of the game. It was Fulham's only good chance of the game, while Sunderland had squandered a number of opportunities in the first half.New signing Cabral was impressive in midfield for Sunderland, although fellow newcomer Jozy Altidore lacked a cutting edge up front. Sunderland had a number of near-misses after the goal as well, with Altidore firing just wide in the 65th and seeing his effort saved by goalkeeper Maarten Stekelenburg 10 minutes later.
Manchester United began their title defence with a 4-1 victory over Swansea in the late kick-off with two goals from Robin van Persie and Danny Welbeck.
Source: Al Jazeera and agencies
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Another season is met with another group of frustrated Arsenal fans who are still waiting for Arsene Wenger to spend big
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text:
Seven Types of Privacy
- Rachel L. Finn,
- David Wright,
- Michael Friedewald
- … show all 3 hide
* Final gross prices may vary according to local VAT.Get Access
As technologies to develop, conceptualisations of privacy have developed alongside them, from a "right to be let alone" to attempts to capture the complexity of privacy issues within frameworks that highlight the legal, social-psychological, economic or political concerns that technologies present. However, this reactive highlighting of concerns or intrusions does not provide an adequate framework though which to understand the ways in which privacy should be proactively protected. Rights to privacy, such as those enshrined in the European Charter of Fundamental Rights, require a forward-looking privacy framework that positively outlines the parameters of privacy in order to prevent intrusions, infringements and problems. This paper makes a contribution to a forward-looking privacy framework by examining the privacy impacts of six new and emerging technologies. It analyses the privacy issues that each of these technologies present and argues that there are seven different types of privacy. We also use this case study information to suggest that an imprecise conceptualisation of privacy may be necessary to maintain a fluidity that enables new dimensions of privacy to be identified, understood and addressed in order to effectively respond to rapid technological evolution.
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- Title
- Seven Types of Privacy
- Book Title
- European Data Protection: Coming of Age
- Pages
- pp 3-32
- Copyright
- 2013
- 10.1007/978-94-007-5170-5_1
- Print ISBN
- 978-94-007-5184-2
- Online ISBN
- 978-94-007-5170-5
- Publisher
- Springer Netherlands
- Copyright Holder
- Springer Science+Business Media Dordrecht
- Additional Links
- Topics
- eBook Packages
- Editors
- Serge Gutwirth (ID1)
- Ronald Leenes (ID2)
- Paul de Hert (ID3)
- Yves Poullet (ID4)
- Editor Affiliations
- ID2. , TILT, Tilburg University
- ID3. , LSTS, Vrije Universiteit Brussel
- ID4. Research Centre for Information, Technology & Law, University of Namur
- Authors
- Rachel L. Finn (1)
- David Wright (1)
- Michael Friedewald (2)
- Author Affiliations
- 1. Crown House, Trilateral Research & Consulting, 72 Hammersmith Road, London, W14 8TH, UK
- 2. Fraunhofer Institute for Systems and Innovation Research ISI, Breslauer Straße 48, 76139, Karlsruhe, Germany
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Posted: Sep. 12, 2012
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Made in a min muffin tin & baked approximately 18 minutes.
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This was taken in my area yesterday. I think many of us have felt this way lately!
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During the Blossom Festival, everyone (an I mean all of Japan) heads to the parks for picnics. The a...
Rhubarb adds its tangy flavor to everything from salsa to lemonade. Don't forget the pie.
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text:
Pablo Martinez Monsivais, Associated Press
CHARLOTTE, N.C. — Democrats open their national convention Tuesday offering President Barack Obama as America's best chance to revive the ragged U.S. economy and asking voters to be patient with incomplete results so far. Michelle Obama, in her opening-night speech, aims to give people a very personal reminder of "the man that he was before he was president."
"The truth is that he has grown so much, but in terms of his core character and value, that has not been changed at all," Mrs. Obama said in interview airing on SiriusXM's "The Joe Madison Show."
The three-day convention has drawn thousands of delegates to a state Obama narrowly carried in 2008. And although Obama no longer is the fresh-faced newbie who leveraged a short Senate career into an audacious run for the nation's highest office, he still can excite partisans, and Democrats were counting on massive numbers to pack a stadium for his speech later in the week.
Virginia Sen. Mark Warner and a host of Democratic partisans worked to rev up delegate enthusiasm, saying Obama has a strong record to defend. They noted the president had helped the economy rebound, presided over an increase in the stock market and brought troops home from Iraq and Afghanistan.
"We've got some truth telling to do," Warner told Florida delegates at a breakfast meeting. "America is better off today than it was four years ago when this president took over."
Newark, N.J., Mayor Cory Booker told the delegates Democrats need to get fully behind Obama, comparing the differences between a large voter turnout in his home state during the 2008 election and a more modest outpouring two years later, when his home state elected Republican Chris Christie as governor.
"Change is never made in a sedentary position," he said.
The Democrats dispatched U.S. Senate candidate Elizabeth Warren, who hopes to unseat Republican Scott Brown in Massachusetts, to make the case for Obama on morning talk shows, and she acknowledged that "it's tough out there" for many Americans. But she insisted that Obama offers the better vision going forward.
"Republicans are not helping us get back," she said.
Warren was up against GOP vice presidential candidate Paul Ryan, the Wisconsin congressman, who held out the millions of people who are struggling to find work as an indictment of the president's first term.
"Four years into a presidency and it's incomplete?" he asked in a round of morning television interviews. "The president is asking people just to be patient with him?"
GOP nominee Mitt Romney's campaign reinforced that message with a new Web video answering Obama's statement that "there are always going to be bumps on the road to recovery." The new video showcases a series of ordinary people who've lost their jobs saying, "I'm an American, not a bump in the road."
Romney, his convention behind him, drove from his vacation home in New Hampshire to the Vermont home of former Massachusetts Lt. Gov. Kerry Healey to spend the day preparing for the fall debates with Obama.
Democrats released a party platform for ratification Tuesday that echoes Obama's call for higher taxes on the wealthy and reflects his shift on gay marriage by supporting it explicitly.
In a nod to dissenters on gay marriage, the platform expresses support for "the freedom of churches and religious entities to decide how to administer marriage as a religious sacrament without government interference."
As with the deeply conservative Republican platform, not all of which Romney endorses, nothing binds Obama to the specifics of the party's manifesto.
The president rallies in Virginia on Tuesday before joining the convention a day later.
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text:
Online media has created a power shift, a buying power shift, from the hands of the sales team to the hands of the people, the consumers.
By Sibongile Lehloo 26 May 2015 13:25
In many industries, technical expertise forms the basis of the company, leaving sales lagging. This is particularly true in the IT space, where techies speak in feeds and speeds and sales leads are rarely found.
22 May 2015 09:17


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Hayden Panettiere chose this fitted dress to the premiere of 'Raising Helen' on May 26, 2004 at El Capitan Theatre in Hollywood, California.
Emma Stone and Andrew Garfield have officially rekindled their love, people.
The couple was spotted grocery shopping at Ralph's together, making it their first public sighting together since January!
Want to see some hilarious celeb pics that will make you LOL? Great, because we have the funniest celeb pics of the week to show you!
Nothing says "vacation" quite like kicking back with an ice cold drink.
Mariah Carey has been struttin' her stuff everywhere lately!


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Robert Rodriguez Joins Live-Action "Jonny Quest" Film
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Swansea, IL
If a football player gets to go to Disneyland after winning the Super Bowl, what does Iron Man get after saving the world in The Avengers? According to Disney Parks Blog, his company gets to set up shop in the Innoventions portion of the California theme park.
On April 13 the park will launch "Iron Man Tech Presented by Stark Industries," an area where visitors can check out the first seven armors featured in the films and also hop into a simulator that lets them feel what it's like to walk in Tony Stark's jet boots and fire his repulsor blasters.
The showcase comes out in anticipation of the May 3 release of Marvel's Iron Man 3. Directed by Shane Black, the film stars Robert Downey Jr., Gwyneth Paltrow, Don Cheadle, Ben Kingsley, Jon Favreau, Guy Pearce, Rebecca Hall, James Badge Dale and Ashley Hamilton.
bring to Epcot please
Disney World and Disney land Tokyo need this as well!
Unfortunately, WDW won't be getting any of this due to Universal.
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The view from our 2nd floor one bedroom villa took our breath away when we arrived. We had a gorgeous view and spent most of our time chilling on the huge balcony in our hammock chairs. The villa was spacious and very clean. We didn't take full advantage of the fully equipped kitchen but it was still handy to have... More
Related hotels...
- Great Value!Akumal, Riviera MayaShow Prices


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Sunday 31 May 2015 10am-5pm, FREE 4pm concert
Have you ever dreamt of performing with a professional orchestra? Maybe you played a musical instrument in the past but not had the opportunity to play for many years? Then now is the time to dust off your instrument and revive your talent! This event is made possible by the support of the Portsmouth Cultural Trust.
Wednesday 17 June 2015 - Saturday 20 June 20157pm/ 6pm. £12.95 incl.BF*
To Be Your Best Foundation presents: 2015 BE YOUR BEST ROCK CHALLENGE.
Saturday 08 August 2015 £12.95 incl.BF*, concessions £10.50 incl.BF*, 2pm
The Royal Marines School of Music will raise the roof when they return to the Guildhall this summer for their biggest and most exciting concert of the year.
Portsmouth Guildhall, Guildhall Square, Portsmouth, Hampshire PO1 2AB Registered Charity No.1153358
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