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A Nation under Our Feet: Black Political Struggles in the Rural South from Slavery to the Great Migration
by Steven HahnThis is the epic story of how African-Americans, in the six decades after their release from slavery, transformed themselves into a political people- an embryonic black nation.
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From tobacco fields and fishing villages, to revolutionist monuments and relaxing beaches, Cuba is home to one of the most captivating cultures in the world. Take in the crumbling facades of colonial buildings, meet chilled out locals puffing on cigars and wiggle your toes in the sand on an isolated beach. Experience Cuba in all its glory and discover the colors, cuisine and culture that make up this truly distinctive country.
Discover the many layers of captivating Cuba
- Amble down the cobbled streets of historic Havana
- Explore Cuba's best-preserved colonial town
- Check out the Bay of Pigs Museum
- Visit a local cigar factory
- Snorkel in the waters off Cayo Blanco
- See the site of Che Guevara's famous train battle
Day 1 Havana
Day 2-3 Vinales
Day 4 Playa Larga
Day 5 Cienfuegos
Day 6-8 Trinidad
Day 9-11 Havana
10 breakfastsTransport
Homestay (8 nights), Hotel (2 nights)Included activites
- Cienfuegos - Coppelia ice cream parlour
- Havana - Vintage American car tour
- Havana - Walking tour of Old Havana
- Santa Clara - Visit to Che Guevara Mausoleum and Museum
- Snorkelling, Caleta Buena
- Soroa - Hike to waterfall
- Trinidad - Ancon beach (transport)
- Trinidad - Trek to waterfall (taxi and entrance fee)
- Valley walking tour
- Vinales - Cueva del Indio
- Walking tour, Cienfuegos
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Age restrictions apply to this trip: minimum age 5.
A discount of 10% applies on this trip to children under 15 years of age at time of travel.
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subset: commoncrawl


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Collection Panoramic Maps
Results for "Chicago, Illinois" 1 - 1 of 1
Refined by:
Sites and Collection: Panoramic Maps Remove Contributor: Currier & Ives Remove Subject: Aerial Views Remove-
The city of Chicago.
Perspective map not drawn to scale. Bird's-eye-view. Shows points of interest. LC Panoramic maps (2nd ed.), 150 Available also through the Library of Congress Web site as a raster image. AACR2
- Contributor: Currier & Ives
- Original Format: Maps
- Date: 1892


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Flu shots remain available during regular drop-in hours at the Whitehorse Health Centre, Mondays through Fridays, from 8:00 to 8:45 a.m. and from 1:00 to 4:00 p.m. on Fridays. Appointments are also available throughout the week by calling 667-8864.
In the communities, call your local health centre for hours of availability.
REMINDER: Children under age 9 who need a second dose should be brought in as soon as possible.
The Whitehorse Health Centre is located at 9010 Quartz Road (between Earl's and The Feed Store).
Whitehorse Health Centre is adding an appointment system to its drop-in hours. People needing catch-up well baby or travel immunizations can now make an appointment and avoid the wait.
Hours of Operation:
Monday - 8:00am to 4:30pm
Tuesday - 8:00am to 6:30pm
Wednesday - 8:00am to 4:30pm
Thursday - 8:00am to 4:30pm
Friday - 8:00am to 4:30pm
Saturday and Sunday - closed
Closed every day: noon to 1:00pm
Immunization Appointments Available:
Monday - 8:00am to 4:30pm
Tuesday - 8:00am to 6:30pm
Wednesday - 8:00am to 4:30pm
Thursday - 8:00am to 4:30pm
Friday - 8:00am to 4:30pm
Saturday and Sunday - closed
Closed evey day: noon to 1:00pm
Dedicated Drop-in Hours:
Monday - 8:00am to 8:45am
Tuesday - 8:00am to 8:45am
Wednesday - 8:00am to 8:45am
Thursday - 8:00am to 8:45am
Friday - 8:00am to 8:45am and 1:00pm to 4:00pm
Saturday and Sunday - closed
Please Note: TB Testing for education, employment and treatment programs is available at Whitehorse Health Centre during these hours. TB testing for other purposes is available at Yukon Communicable Disease Control at #4 Hospital Road in Whitehorse
For more information on our services or to make an appointment, please call 867-667-8864 or toll-free in Yukon 1-800-661-0408 extension 8864.
Outside of Whitehorse
Health Centres have their own clinic hours. Please contact the Health Centre in your community for clinic information and times. Call your local health centre at your community prefix -4444.
Whitehorse Health Centre
9010 Quartz Road
(867) 667-8864


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Semi-retired teacher. Previous occupation: Mechanical Enginer. Live with 80 miles, will ensure all maintenance items will be taken care of the same day. Provides phone numbers of plumbers, electrician, cable and internet provider, wireless home network.
3 BR / 2 BA / Sleeps 6
Left on Jul 19, 2013 for a stay in July 2013
We were on the Cape for a wedding. We stayed here and had local family come visit for dinner a few nights. It was perfect. Nice, safe neighborhood, great playground at the nearby school, the beach is about a 5 minute drive. The washer/dryer are downstairs in the basement, everything else is on the main floor. The a/c was appreciated on the humid days. The Tv's were small, we aren't TV …


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NWAR: Trench Warfare
Detective Nwar gets his hands dirty for a political campaign.
4.42 / 5.00 2,871 ViewsAfter 13 days of hard work, I managed to whip this up before my 3rd day at school. I worked extremely hard on this one, spending a few hours at night just drawing and setting the scenes.
Taegukgi - my 3rd attempt at a war movie, I think I did good.
And yeah, 'Taegukgi' as actually the name of a motion-picture, which inspired me to animate something similiar.
Thanks all.
Animated for the WarZone Competition running on StickSlaughter.com
Power-Fusion.com - 2005 - ToughLuck
Again, another mastering flash
I must also comment to the guy 3 reviews below. Calm down, this is just a flash, its not real. Accidents happen in war, i know you are mad because of that incident, im very sorry to hear that, but you shouldnt blame it on a flash that this guy made to impress and entertain us.
Anyway i loved the flash, great work! I loved the many different effects that you used, the camera jerking and motion blur gave it an effect as though you were in a movie, it was almost like Saving Private Ryan, well done! Hope to see more of your work!
Very Very Nice
Hey! Great work dude, i love this, as has been said, few war movies pull off the stuff you can, this goes for all Taegukgi movies, they just keep getting better.
@ The Guy Two Reviews Down: You suck, it's a movie, people get killed by bombs bullets and all, so don't try to show you know everything, i can list all the parts of an AR-15 but i don't.
Back to the flash, anyhow, this is great work, as said by a guy a few down, belts, webbing ect would enhance the effect, but it's a stick animation, but the way the enemy soldiers lean over the wall at the start looked a little tacky, and the auto fire on the M16's sounded like rapid semi auto, if you meant that, that's good, but full bursts would sound way better.
Make the helmets slightly larger, so they don't look like baseball caps without the peak, but as said, having seen the other Taegukgi animations, it just gets better.
If you were to direct or make movies, you'd be a very rich man, or make games like this, either way really really cool, seriously, if you wrote script and scene plots for movies, you'd make alot of money, especially in the anime industry, but yeah, hope you do well in your future life, stay cool.
Very Well Done
Very well done, there isn't much else to say as this is one of the best stick animations of its kind.
@the guy who reviewed this before me: Dude, chill out. This is a small Flash animation, also, many people die from being shot in wars. You have no clue how many people die of that. It is true that bombs are used a lot, but people still carry guns and still use them. There are constant conflicts involving two factions shooting at eachother, and many soldiers on both sides dieing from being shot. Don't be such an asshole. Also, how do you know the marine "just dropped" the grenade, it would have most likely killed everyone in the room depending on its dimensions. Also, a marine can have a grenade, he's a marine. This animation is for fun, only assholes like you can find a way to take it seriously.
One 'Taeguki' is the name of the Korean flag and two in wars people usually die because of bombs,explosions and other injuries not because of bullets u god dammed moran try researching before u make something like this
I know this cuz I'm a Korean and my gramps died in WWII because of this stupid US marine who accidently dropped a grenade(they were both in the same team and they were in the same room) the marine shouldn't even had the grenade. DS Dumb Shit
one request
Ahh... I've watch this movie like 20.000.000 times but it stays just as good. Your style is so amazing and your graphics to. I just wanna know. Everytime you make a movie you put in beautiful dripping blood. But i just wanna know. cause wen you see this revieuw please can you say how you make that beautiful dripping blood. Because I tried in like 20 thousand times but i just suck


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Life as a mother of only boys
Bernie Sanders is a socialist. What does that even mean?
How modern capitalism killed self-reliance
34 TV shows to watch in 2015
Harry Reid: The filibuster is like a 'pirate craft'
Hillary Clinton just cornered the GOP on immigration
This ex-military spy drone could be headed to your house
Why the American tourist could become virtually unrecognizable by 2050
New York City Mayor Bill de Blasio wants to create the left's version of the 'Contract with America'
The Vatican is officially making Rev. Junipero Serra a saint
Iowa poll ranks Jeb Bush 7th among Republican 2016 hopefuls
Rangel: The Democrats' millstone?


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While Apple's iPad mini was found to have the fastest touchscreen, at least amongst tablets, and with Apple's iPhone 5s and iPhone 5c also being twice as responsive compared to their Android competition, we're not sure if speed matters especially given that after certain tests were conducted that it was found that both devices' touchscreens were not as accurate compared to competing products, like the Samsung Galaxy S3. This is according to a test conducted by Finnish testing company, OptoFidelity, who found that during their testing using software and a robotic finger, that the edges of the iPhone 5s and iPhone 5c were poor at detecting touches, a disadvantage that could affect overall typing accuracy on the devices.
For example trying to hit the letters Q, O, and P, could be harder for iPhone 5s and iPhone 5c users due to the touchscreen reportedly being less accurate, although in all fairness keyboard accuracy on iPhone devices has not exactly been a major complaint by iPhone users to date. The Samsung Galaxy S3 on the other hand was found to have near-uniform accuracy across the display, suggesting that typing accuracy on Samsung's smartphone should in theory be more accurate. Our review of the iPhone 5s did not find much fault with the onscreen keyboard, so perhaps the lack of accuracy is made up by good predictability and autocorrection. In any case what do you guys think? Is this something you've noticed on your iPhone 5s or iPhone 5c prior to being informed of its inaccuracy?
Filed in iPhone 5C and iPhone 5S. Source: electronista
. Read more aboutKey Specs | iPhone 5s | iPhone 5c |
Status | Released | Released |
Resolution | 1136x640 | 1136x640 |
Display Diagonal | 4" | 4" |
Processor/Soc Name | A7 2-core 1.3 GHz | A6 2-core 1.3 GHz |
Max. Total Storage Capacity | 64 GB | 32 GB |
Megapixels | 8 MP | 8 MP |
Battery Capacity (mAh) | 1560 mAh | 1510 mAh |
Street Price | $649 | $549 |
Complete product data | Apple iPhone 5s Full specs | Apple iPhone 5c Full specs |


text:
More About LILHLFPINT
Visit My SparkPage Send Me SparkMail
Recipes I've Shared:
Spring4Fal's Green Smoothie
Sparker Spring4Fal's tasty smoothie recipe. Add a half scoop of your favorite protein powder.
Recipes I've Rated:
- Crockpot Taco Soup
- Low-Carb Crockpot Creamy Caesar Mushroom Chicken
- Crockpot Chicken Tortilla Soup
- Crunchy Cabbage Ramen Noodle Salad
- italian vinaigrette salad dressing
- Guilt Free French Toast
- Pico de Gallo - Authentic Mexican Salsa
- Greek-Style Butter Beans
- Applesauce Oatmeal Muffins
- Homemade Garlic Hummus
- Tasty Swiss chard
- Quinoa a la Tricotine
- Finger Lickin' Black Beans
- Balsamic Grilled Chicken Breast
- Easy Low Calorie Reuben
- Best Ever Turkey Meatloaf
- Skillet Lasagna
- Tomato, Feta Cucumber Salad
- Turkey Apple Wrap
- Katie's Summer Peach Crisp
- Balsamic-Glazed Pork Chops
- Mom's Cheesecake
- Chicken Breasts Stuffed with Goat Cheese and Sun-Dried Tomatoes
- Leprachaun Pie
- Lemon Herbed Couscous
- tart and tangy pork chops
Recipe Collections I've Shared:
(lil 1/2 pint's favorite sparkrecipes...) |


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Deux adultes et deux enfants, 4 et 8 ans. Nous aimons beaucoup voyager dans le monde.
Максим has completed online and offline ID verification.
Max, his wife and his 2 boys are great guest! They are nice, serious, clean and easy going. I recommand them to anyone who would like to meet and too host this wonderfull familly!


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Pharmacokinetics, Efficacy and Safety Study of IMMUNATE SD (Human Plasma-Derived Coagulation Factor VIII Concentrate) in Hemophilia A Patients
- Full Text View
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- How to Read a Study Record
The purpose of this study is to evaluate whether IMMUNATE S/D is effective and safe in the treatment of hemophilia A patients. The study consists of 3 parts: Part 1 is a pharmacokinetic comparison of IMMUNATE S/D and its predecessor IMMUNATE. Part 2 is an evaluation of efficacy and safety of IMMUNATE S/D. Part 3 is a pharmacokinetic study of IMMUNATE S/D.
Condition | Intervention | Phase |
Hemophilia A |
Drug: Human Plasma-Derived Coagulation Factor VIII Concentrate (Virus Inactivated by Polysorbate 80 Treatment and Vapor Heat Treatment) |
Phase 3 |
Study Type: | Interventional |
Study Design: | Allocation: Non-Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Diagnostic |
Official Title: | Phase 3, Prospective, Multicenter Study to Evaluate the Pharmacokinetics, Immunogenicity, Safety, and Efficacy of IMMUNATE Solvent Detergent (IMMUNATE SD) in Previously Treated Patients With Severe or Moderately Severe Hemophilia A |
- To compare the PK parameters of IMMUNATE S/D and IMMUNATE in subjects with severe hemophilia A (baseline factor VIII <= 1%)
- to re-evaluate PK parameters for IMMUNATE S/D after a minimum of 14 weeks ± 7 days of treatment with at least 10 exposure days with IMMUNATE S/D
- to monitor the incidence of factor VIII inhibitor development over a minimum of 27 weeks ± 7 days or at least 50 exposure days, whichever occurs first, in all subjects
- to evaluate the hemostatic efficacy of IMMUNATE S/D in the management of acute bleeding episodes and in the perioperative management of surgical prophylaxis, if required, over the same period of treatment
- to assess the clinical safety of IMMUNATE S/D
- to retrospectively explore the PK parameters of the VWF moiety of IMMUNATE S/D in subjects with severe hemophilia A (baseline factor VIII <= 1%).
Enrollment: | 56 |
Study Start Date: | March 2003 |
Study Completion Date: | August 2004 |
Primary Completion Date: | August 2004 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 12 Years to 65 Years |
Genders Eligible for Study: | Male |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Plasma factor VIII level as follows: for Parts 1 & 3: Subjects with severe hemophilia A (plasma baseline factor VIII level <= 1% measured at time of screening) for Part 2: Subjects with severe (plasma baseline factor VIII level <= 1% measured at time of screening) or moderately severe hemophilia A (plasma baseline factor VIII level <= 2% measured at time of screening)
- Males >= 12 but <= 65 years of age
- >= 35 kg body weight
- Previously treated with factor VIII concentrate(s) for a minimum of 150 exposure days (as documented in the subject's medical history)
- Evidence of a protective titer to HAV and HBV at the time of screening
- Immunocompetent as defined by a CD4+ lymphocyte count >400/mm3 and an absolute neutrophil count (ANC) >1500
- Signed informed consent obtained from subject or legally authorized representative
Exclusion Criteria:
- Documented history of inhibitor to factor VIII with a titer >= 0.8 BU
- Current evidence of inhibitor to factor VIII with a titer >= 0.8 BU, measured at the time of screening
- Abnormal renal function (serum creatinine > 1.5 mg/dL)
- HIV-seropositive individuals with any of the following at the time of screening:
- CD4+ lymphocyte count >400/mm3
- AIDS-related complex
- symptomatic AIDS Note: HIV-seropositive subjects with an absolute CD4+ lymphocyte count > 400/mm3 are eligible to participate. HIV-seropositive subjects receiving highly active anti-retroviral therapy (HAART) regimens are eligible for enrollment if they are not excluded by the above criteria
- Active hepatic disease (ALT and AST levels > 5 times the upper limit of normal)
- Clinical or laboratory evidence of hepatic cirrhosis including (but not limited to) a recent and persistent INR (international normalized ratio) > 1.4, the presence of splenomegaly and/or significant spider angiomata on physical exam, and/or a history of esophageal hemorrhage or documented esophageal varices
- Known hypersensitivity to IMMUNATE
- The subject is currently participating in another investigational drug study, or has participated in any clinical study involving an investigational drug within 30 days of study entry
- The subject is currently receiving, or is scheduled to receive during the course of the study, an immunomodulating drug other than anti-retroviral chemotherapy (e.g., a-interferon, steroids at a dose greater than 10 mg/day)
- The subject is identified by the investigator as being unable or unwilling to perform study procedures
Please refer to this study by its ClinicalTrials.gov identifier: NCT00162019
Bulgaria | |
National Centre of Hematology and Transfusiology | |
Sofia, Bulgaria, 1756 | |
Czech Republic | |
University Hospital Motol | |
Prague, Czech Republic, 150 06 | |
Hungary | |
National Medical Center, National Hemophilia Center | |
Budapest, Hungary, 1135 | |
Poland | |
Klinika Hemetologii I Onkologii Dzieciecej | |
Warsaw, Poland, 00-5 76 | |
Klinika Hematologii i Onkologii Dzieciecej | |
Wroclaw, Poland, 50-345 |
Principal Investigator: | Baxter BioScience Investigator | Baxter BioScience |
No publications provided
Responsible Party: | Brigitt Abbühl, MD, Baxter |
ClinicalTrials.gov Identifier: | NCT00162019 History of Changes |
Other Study ID Numbers: | 040201 |
Study First Received: | September 8, 2005 |
Last Updated: | April 21, 2008 |
Health Authority: | Bulgaria: Bulgarian Drug Agency Czech Republic: State Institute for Drug Control Germany: Paul-Ehrlich-Institut Hungary: National Institute of Pharmacy Poland: Ministry of Health |
Keywords provided by Baxter Healthcare Corporation:
Factor VIII Deficiency |
Additional relevant MeSH terms:
Hemophilia A Hemophilia B Blood Coagulation Disorders Blood Coagulation Disorders, Inherited Coagulation Protein Disorders Genetic Diseases, Inborn Genetic Diseases, X-Linked |
Hematologic Diseases Hemorrhagic Disorders Factor VIII Coagulants Hematologic Agents Pharmacologic Actions Therapeutic Uses |
ClinicalTrials.gov processed this record on April 16, 2015


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When comedians get onstage, they open their lives to audiences and to any burglars who realize they won't be home for hours. Help yourself to comedic treasures with this GrouponLive deal.
The Deal
- $19 for one ticket to see Anchorman's David Koechner (up to $37.61 value)
- When: Friday, February 14, at 7 p.m.
- Where: Turner Hall Ballroom
- Section: general admission
- Door time: 6 p.m.
- Ticket values include all fees.
Anchorman's David Koechner
David Koechner's got one of those faces. An SNL vet and seasoned stand-up, Koechner and his recognizable mug have made appearances in more than 120 movies and television shows, including Thank You for Smoking and NBC's The Office (as foulmouthed bully Todd Packer). There's one role, however, that will probably get him interrupted in restaurants for the rest of his career: Champ Kind, the sportscaster for KVWN in Anchorman: The Legend of Ron Burgundy and its 2013 sequel.
In his energetic, bluster-filled live sets, Koechner busts out the razor-sharp timing that have made his film performances and YouTube channel so memorable. The "Together Again" tour—stopping off at nine cities and lots of gas stations—won't stop at jokes and stories about Koechner's life as a father of five. It'll also find him disappearing into the many characters he's developed, such as carnival huckster Gerald "T-Bones" Tibbons.
Pabst Theater
Captain Frederick Pabst contributed to Milwaukee's status as a cultural landmark of the upper Midwest by building Pabst Theater, formally known as Das Neue Deutsche Stadt-Theater, in 1895. According to legend, when he was informed that his theater had burned to the ground, the brewing magnate interrupted his European vacation to wire home the order to "Rebuild at once!"—and 11 months later, the stage was completed anew. Where the old theater honored German artists by having their names inscribed along the cornice of the auditorium, the new building featured an international consortium of cultural notables. The theater's globe-spanning influences were made even more apparent with the installation of an Austrian crystal chandelier and an Italian marble staircase.
100% of 15 customers recommend
"No bad seats and great experience :)"
"Beautiful venue, great style! Enjoy a PBR!"
"Everything was great"


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Sorry, but your web browser is too old to display this page properly. Please update it to the latest version or switch to a more modern browser, like Firefox, Opera, Google Chrome or Safari or Internet Explorer 11 (they're all free).
A warm welcome awaits you at The Slaters Arms in Cannich, Strathglass - the gateway to the magnificent Glen Affric and just a short hop from Loch Ness. The present owners have tastefully renovated the premises to a high standard over recent years. The refurbishment has included adding a sun-room and an extensive decked area at the rear of the restaurant, allowing visitors to enjoy the excellent views along Strathglass towards the hills of Cougie & Glen Affric.
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One tool to help you manage your secure shell connections is the GNOME SSHmenu tool. This helpful application adds a small applet to the GNOME panel that allows you to make secure shell connections with a single click.
Full story »
http://www.ghacks.net –
Created by keyboardninja 5 years 8 weeks ago – Made popular 5 years 8 weeks ago
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The Voices of Wittgenstein: The Vienna Circle : Ludwig Wittgenstein and Friedrich Waismann
The Voices of Wittgenstein brings for the first time, in both the original German and in English translation, over one hundred short essays in philosophical logic and the philosophy of mind. This text is of key historical importance to understanding Wittgenstein's philosophical thought and development in the 1930's. Transcribed from the papers of Friedrich Waismann and dating from 1932 to 1935, the majority are highly important dictations by Wittgenstein to Waismann. It also includes texts of redrafted material by Waismann, closely based on these dictations.
Additional information
Place of publication:
- London
- 2003


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Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar (glucose) levels that result from defects in insulin secretion, or action, or both. Inspired by previous report the release of ATP from RBCs, which may participate in vessel dilation by stimulating NO production in the endothelium through purinergic receptor signaling and so, the aim of this study is to clearly determined relationship between RBC ATP/ADP ratio with nitric oxide.
The ATP/ADP ratio of erythrocytes among four groups of normal individuals (young & middle age), athletes' subjects and diabetic patients were compared and the relationship between ATP/ADP ratio and NO level of plasma was determined with AVOVA test and bioluminescence method.
ATP/ADP level in four groups normal (young & middle age), athletes, diabetes] are measured and analyzed with ANOVA test that show a significant difference between groups (P-value < 0.001). A significant positive correlation was found between RBC ATP/ADP content (r = 0.705; P < 0.001). Plasma NO content is also analyzed with ANOVA test which shows a significant difference between groups.
In this study, a positive relationship between RBC ATP/ADP ratio and NO was found. Based on the obtained result, higher RBC ATP/ADP content may control the ratio of plasma NO in different individuals, also this results show that ATP can activate endothelial cells in NO production and is a main factor in releasing of NO from endothelial cells.
Diabetes; ATP/ADP; Nitric oxide; Red blood cellIntroduction
Diabetes mellitus is a group of metabolic diseases which interfere with energy homeostasis [1]. Diabetes is one of the most costly chronic diseases with an estimated worldwide prevalence of 170 million in 2002, which is expected to double by 2030 according to the World Health Organization [2]. The most common macrovascular complication of diabetes is atherosclerosis, which increases the risk for myocardial infarction, stroke, and peripheral artery disease, the latter being the leading cause of limb amputation in civilized countries. Microvascular complications consist of retinopathy and nephropathy, the leading causes of blindness and renal failure [3]. There is now substantial evidence indicating that endothelial dysfunction, characterized by diminished endothelium dependent relaxation, is abnormal in experimental models of diabetes [4-8]. Several other studies have also demonstrated impaired endothelium dependent vasodilation in human diabetic patients [9,10]. There is substantial evidence suggesting that high concentrations of glucose could reduce NO availability due to an increase in superoxide anion production [11]. Further, elevated glucose levels may lead to a decrease in cellular concentrations of nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) through activation of the polyol pathway [12]. As NADPH is an essential cofactor of NO synthase (NOS) for NO synthesis, its depletion could lead to a reduction in endothelial NO production. NO mediates the endothelium-dependent vasodilation in response to stimuli such as shear stress, insulin, and acetylcholine [13]. Recent evidence suggests that NO interacts with other flow-induced vasodilation mediators, including prostacyclin and adenosine, and this interaction results in net hemodynamic changes. NO has also been shown to mediate exercise-induced vasodilation [14]. As a potent endogenous vasodilator, NO has numerous beneficial effects that preserve normal vascular function. For example, NO activates guanylate cyclase in vascular smooth muscle, and increases the production of cyclic guanosine monophosphate (cGMP). cGMP, as a second messenger, mediates many of the biological effects of NO, e.g. causing relaxation of smooth muscle and inhibiting platelet aggregation [15]. In addition, NO inhibits platelet activation and adhesion to the surface of endothelium. NO reduces vascular oxidative stress and inhibits superoxide generation [16,17]. In addition, NO stimulates angiogenesis, which plays an important role in wound healing, vascular remodeling, and conditions like myocardial infarction and diabetic retinopathy [18]. NO is also a mediator of the immune response, a neurotransmitter, a cytotoxic free radical and a widespread signaling molecule [16,18]. NO stimulates insulin release from pancreatic ß cells in the presence of glucose [19]. These properties suggest that the level of NO production by the endothelium may play a pivotal role in the regulation of vascular disease. Therefore, impaired endothelial NO production may constitute a critical manifestation of proatherogenic events in the vascular wall, including increased vascular tone, platelet aggregation, endothelial barrier dysfunction, vascular inflammation, and smooth muscle cell proliferation. Nisoli et al [20] recently reported that the NO-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance. For example, NOS null mutant mice had a reduced metabolic rate and accelerated weight gain [20], insulin resistance [21], hypertension, and hyperlipidemia [22]. Accordingly, it was reported that the red blood cell (RBC) is a determinant of endogenous nitric oxide (NO) synthesis in the pulmonary circulation; i.e., in the isolated perfused rabbit lung, RBCs obtained from either rabbits or healthy humans were required component of the perfusate in order to demonstrate flow-induced endogenous NO synthesis [23]. RBCs contain concentrations of ATP adequate to activate the endothelial P2y purinergic receptors, resulting, thereby, in synthesis of NO [24,25]. Importantly, the component of blood, responsible for the stimulation of endogenous NO synthesis, was determined to be the RBC, via the release of adenosine triphosphate (ATP) [26]. Indeed, the application of ATP to endothelial cells resulted in an increase in NO synthesis [24,27]. ATP is of particular interest because it is present in millimolar amounts in RBCs [28]. In the present study, we investigated the RBC ATP/ADP ratio and plasma nitric oxide in different groups (normals, diabetes). We characterized a significant coherency between ATP/ADP and nitric oxide .in addition, in this study we determined these factors in athletics' subject, all of them were jodo national team. Finally, to bold the results, they comparison with each other.
Materials and methods
In this study we investigated on human subjects, all control subjects were healthy volunteer living in the community, and none was acutely ill. None exhibited evidence of cardiac or chronic kidney disease and all were euthyroid with normal liver function tests and normal value for plasma urea, creatinine and electrolytes. Furthermore, healthy subjects were drug free and with a negative family history of diabetes mellitus or hypertension. The subjects were fully informed of any risks and discomforts associated with the experiments before giving their informed written consent to participate. The studies conformed to the code of Ethics of the World Medical Association (Declaration of Helsinki) and were approved by the Ethics Committee of Shariati Hospital, Tehran University of Medical Science of Iran. RBC of 40 uncontrolled diabetes patients was collected (40-65 years) and at the time of the study (HbA1C% 8.79 ± 0.19) we also collected RBC from 60 healthy volunteer (23-55 years), this group was divided into three classes, normals [young individuals ( 20-33 years) and middle age subjects ( 40-55 years)] and athletes (20-33 years). The following parameters were determined in all blood samples which collected at early morning after overnight fast: erythrocyte ATP, ADP content and plasma nitric oxide (NO) level.
ATP assay method in RBC
ATP was measured by luciferin-luciferase technique [29,30]. In which the amount of light generated by the reaction of ATP with recombinant luciferase is dependent on the ATP concentration. Sensitivity was augmented by addition of the D-luciferin to the luciferase. A, 50 μl sample of RBC, lysed with TCA 10% (tricoloroaceticacid) and neutralized with KOH 1 M and diluted with hepes buffer 100 mM pH 7.8 (1:64), injected into a cuvette containing 10 μl luciferin (sigma), 10 μl Mgso4, 10 μl luciferase(1 mg/ml). The peak light efflux from cuvette to which either known ATP standards or samples are added was determined using a luminometer (Sirius tube Luminometer, Berthold Detection System, Germany), a ATP standard curve was obtained on the day of each experiment.
RBC ADP assay procedure
ADP was measured by the coupled assay of pyruvate kinase with luciferin-luciferase technique [31], in which at first we injected 5 μl pyruvate kinase (1 mg/ml) into a cuvettes containing 50 μl RBC (lysed, neutralized and diluted), 5 μl PEP (phospho enol pyruvate 20 mM, sigma), 5 μl KCl and patience for 7 min since the ADPs existed in the sample converted to ATP, then added 10 μl luciferin (10 mM), 10 μl luciferase (1 mg/ml) and 10 μl Mgso4. The peak light efflux from cuvette to which either known ADP standards or samples are added was determined using a luminometer, an ADP standard curve was obtained on the day of each experiment.
NO assay procedure
NO was measured by the dye assay based on Griess reaction [32]. In this study to inhibition of blurred solution which interferes with assay we used Znso4 as a protein degenerative (solution clarification) [33,34]. In this assay which act based on Griess reaction, added 100 μl a mixture of solution, NEDD (N-1-naphtylethylenediamine) and sulphanomide (1:1) to 100 μl of clarified serum, to doing reaction and dye forming, solution mixture placed into incubator 37°C for 30 min. after this time dye formed from this reaction measured at 540 nm by Elisa reader ( Sunrisa, Tecan, Austrian).
Statistical method
Statistical significance among experimental periods and groups was determined with analysis of variance, Tamhane test and Scheffe test for multiple comparisons, Bivariate correlation for relation between variables and regression for prediction. A P-value 0.05 or less was considered statistically significant. Results are reported as the means ± SEM.
Human subject studied
RBCs are taken from 40 male diabetic patients who were diagnosed according by American Diabetes Association Guideline 2011 [35]. The average age of the patients was 60.5 ± 1.7 years. Baseline characteristic data are summarized in Table 1. In addition, RBC of 60 healthy human volunteers [20 athletes, 40 Normals (20 youngs, 20 middle age)] with equal sex for all was sampled. Average ages for athletic individuals without medication and history of diabetes disease, was 27.7 ± 0.61 and for normal control was 26.7 ± 0.49 and 50 ± 0.60.
Table 1. Age and sex characteristics of studied subjects: Erythrocyte ATP/ADP and plasma NO content, Tamhan test for ATP/ADP group comparison, as shown in this table the difference between groups are significant (P-value <0.001)
ATP/ADP level between groups
In this study the control individuals divided to three groups, normal (young) & normal (middle age) and athlete individuals. ATP/ADP level in four groups (Normal (Y) & Normal (M), athletes, Diabetes) was measured and analyzed with ANOVA test, the result showed a significant difference between groups (P value < 0.001), the result are summarized in Table 1 and Figure 1.
Figure 1. The comparison of ATP/ADP level among 4 groups (diabetes, Normal (Y = young, M = middle age) and athletes.
NO level between groups
In this study we measured NO by dye assay and result was analyzed with ANOVA test. As the difference variance between groups was not significant, data were analyzed with fisher and Scheffe test. The results are summarized in Table 1 and Figure 2.
Figure 2. The comparison of NO level among 4 groups (diabetes, Normal (Y = young, M = middle age) and athletes.
Correlation between RBC ATP/ADP content and NO
A significant positive correlation was found between RBC ATP/ADP content (r = 0.705; P < 0.001). In this study, a positive relationship between ATP/ADP and NO is found, accordingly; 0.705 unit increase in NO is accompanied by 1 unit increase of ATP/ADP ratio. Therefore, based on experimental measurements reported here, using B Coefficient a formula for prediction of ATP/ADP ratio could be obtained : ATP/ADP = -0.990 + 0.105 [NO].
Nitric oxide (NO) is an omnipresent intercellular messenger in all vertebrates, modulating blood flow, thrombosis, and neural activity. Ellsworth et al. 1995; Sprague et al. 1996 had reported the erythrocyte, via its ability to release ATP, has been identified as a potential regulator of vascular resistance once released from the erythrocyte into the circulation, ATP can activate purinergic receptors, specifically those of the P2y subfamily, present on the vascular endothelium, resulting in the synthesis and release of NO. NO released abluminally interacts with vascular smooth muscle, resulting in its relaxation [36,37]. Controversially, Jaffrey J. etales have reported that inhibitory action of NO on ATP release from erythrocytes is the result of inactivation of one or more components of signal transduction pathway which contribute in ATP releasing in RBC. In this study we measured RBC ATP/ADP content and plasma NO between four groups (Normal (young) & (middle age), athletes, diabetes) (Figures 1, 2 Table 1). The present study investigate the relationship between of RBC ATP/ADP content and plasma NO level and the effect of exercise on RBC ATP/ADP content and plasma NO production. A positive significant correlation (Figure 3, Table 2) between plasma NO and ATP/ADP content of RBC among four groups has been observed. This observation suggests higher metabolic rate (ATP/ADP ratio) in athletes in comparison with normal and type2 diabetes. Other study reported that athletes have high ATP/ADP content in comparison with normal subject [38]. No correlation between RBC ATP/ADP content and plasma NO level has ever been reported. It is a sight of thought that plasma NO is a signal for inhibition of platelete aggregation and also is a signal for velocity in blood flowing which lead to wound healing. Previous works show that exposure of endothelial cells to oxidants leads to cellular energetic crisis, which is prevented by Poly (ADP ribose) polymerase (PARP) inhibition [39] this event simultaneously led to oxidative and peroxidative injury, decrease in NAD+, NADPH which make decrease in ATP production and eNOS activity which led to endothelial dysfunction (Figure 4). Sprague et al. (1996) reported that both rabbit and human erythrocytes release ATP in response to mechanical deformation produced by passage of erythrocytes through filters with an average pore size of 5 μm. Indeed, it has been reported that the RBCs from people with type 2 diabetes are less deformable than those RBCs obtained from healthy controls [40-42]. Have any role nitric oxide in cell metabolic rate? There is now clear evidence for a role of nitric oxide (NO) in mitochondrial biogenesis. NO donors increase the protein and mRNA expression of peroxisome proliferator-activated receptor coactivator 1 (PGC-1), nuclear respiratory factor 1 (NRF-1), and mitochondrial transcription factor A (mtTFA) in muscle cells and adipocytes of rodents [43], which are involved in coordinating mitochondrial biogenesis [44,45]. This process is dependent on the downstream messenger of NO, cGMP, via the activation of soluble guanylate cyclase (sGC) [43]. Furthermore, blocking the activation of sGC also blocks mitochondrial biogenesis induced by NO donors [43]. As mentioned above in athletes the ATP/ADP ratio and NO have a more positive significant in comparison with others, this due to exercise led to increase in ca+2 and then activation of nitric oxide synthase from a series of signal such as increase in ATP/ADP ratio, NADPH ,… and also decrease in reactive oxygen species(ROS) [46] (Figure 5).
Figure 3. Correlation between NO and RBC ATP/ADP with bar curve.
Table 2. Pearson correlation between ATP/ADP and NO, this table showed that if NO 0.705 increased ATP/ADP level 1 unit increased
Figure 4. Proposed scheme for the potential mechanism of factors which contribute in endothelial dysfunctionin the diabetic myocardium leading to improvements in eNOS function.
In conclusion, according to the result obtained in this investigation; the relationship between RBC ATP/ADP ratio and plasma NO is a positive significant and have a reciprocal correlation these factors was high in athletes and normal individuals in comparison with diabetic patients. It seems that ATP/ADP content may be considered as a main stimulator for NO secretion from endothelial cells, diabetes control and diabetic consequence such as stroke.
Competing interest
The authors declare that they have no competing interests.
Authors' contributions
Nuredin Bakhtiary: had the main role in design, performance analysis of data, wrote of manuscript. Saman Hosseinkhani: supervisor of this project and help this idea both laboratory facilities and financial and deliver advantage guidance to progress this idea. Mohammad- reza mohajeri tehrani: the corresponding author of this project and had a benefit guidance in selecting individual( diabetes, controls and athletes) and approved this idea in shariati hospital gland & metabolism researcher center. Abbas Fallah: role in collecting athletic subjects form national Olympic commitee of Iran (judo national team). All authors read and approved the final manuscript.
I'll be appreciate from all of collaborate in this project specially authors' manuscript which do their best in progress this idea.
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runBus successfully re-launched its full-fledged bus ticket booking platform with more routes and features to travel India's different locations easily and comfortably by your choice of seats and buses by budget to luxurious buses offering different
June 23, 2014 (Newswire) - By runBus Team
Delhi, India: runBus is a sister concern venture of Stonehenge Ecommerce Private Limited offering complete solution for IT related requirements of diverse range of clients recently re-launched after the completion of its lingering updates required to make the platform better and more user-friendly to book bus tickets easily, securely and comfortably o travel to India's different locations safely and conveniently.
"The notion of re-launching full-fledged bus ticket booking platform was to provide people with more options keeping in mind the increasing number of passengers day by day. There are very limited options available for people to book bus tickets online, said the managing director of runBus". The company in the year 2012 launched a smaller version of runBus with limited options of routes. To offer passengers with more options and routes, it again launched a matured version of runBus.
"You will see some more features that are in running process and soon will be launched. Our first and foremost goal is to serve the requirements of increasing number of passengers in the peak seasons, mainly in the occasions of festivals when everyone is in hurry to reach hometowns who has come to different cities, states or towns in the search of bread and butter. Those who have to travel on urgent basis fail to find public transport facilities in the peak season, said the managing director of runBus".
About runBus
runBus is a very secure, reliable and user-friendly platform for booking bus ticket to travel different parts of India comfortably in your choice seats and buses.
E-42, Street Number 15, Madhu Vihar, IP Extension, Delhi - 110092
Phone: 011-65331313
Email ID: firstname.lastname@example.com
Website: www.runBus.in


text:
Spell Check of precedent
Correct spelling: precedent
Definition of precedent:
preceding in time, order, or significance
Common misspellings for precedent:
- precident (53%)
- precendent (12%)
- presedent (10%)
- precedant (2%)
- prescedent (2%)
- prescident (2%)
- precedented (2%)
- precdent (2%)
- presadent (2%)
- precedential (2%)
Examples of usage for precedent:
1) A precedent is an authoritative case, example, or instance. The communism of the early Christians in Jerusalem is a wonderful example or instance of Christian liberality, but not a precedent for the universal church through all time. Cases decided by irregular or unauthorized tribunals are not precedents for the regular administration of law. An obiter dictum is an opinion outside of the case in hand, which can not be quoted as an authoritative precedent. Compare CAUSE; EXAMPLE.


text:
New Delhi: A portion of the tent where women were sitting at yoga guru Ramdev`s protest venue at Ramlila Maidan fell due to heavy rains on Saturday.
The incident took place at around 1:30 pm.
As soon as the rains began, the tent on the right side of the pandal collapsed putting the women protesters in inconvenience.
Many ran to other portions of the pandal.
There were breaches throughout the tent, making the ground muddy as water was collected in places where people were sitting.
No one was injured.


text:
200W Amplifier Circuit TDA2030 New PCB
2 Piece TDA2030A output power transistors connecting the power upgraded 200w amp circuit We all know I think this circuit, the first in 2000 Elektor I saw it in a long thin pcb printed circuit drawings had worked fine had in fact circuit the purpose of making my hand on my transformer was to evaluate the circuit from a single source because it runs my business had arrived circuit 12v … .36 v between supply and can run, but 12v and the efficiency is not good work best 24v …. 36v from happening suggestion at least 20v power use ..
Anyway, let's get a new printed circuit event this circuit to do it again decided , but first I made PCBs now my eye to look nice did not :) on the internet a bit some research to have done much more in a drawing found , but these drawings used in the transistors of the leg links of non-standard ( bd508 , bd705 ) base and emitter in the opposite direction also drawing some departments did not like me again printed circuit drew new drawing was more orderly in addition to input and output supply and speaker make out the clamps on the output line fuses 've added a smaller size was
As I said, I did not get 12v to 24v with a yield tests worked fine for power transistors TIP35C, I used tip36c bd249 bd250 used instead.
PCB (tda2030-yeni-pcb.LAY) "Sprint-Layout-Viewer" http://www.abacom-online.de/uk/html/dateien/demos/viewlayout50.exe
all files: 200w-amplifier-circuit-tda2030-new-pcb.rar
Previous project Digital Analog Graphic LCD Clock Circuit MCB1700 LPC1768 suggest reading the article. arm project provided information about the.


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Feb 19, 2013The Metal Gear myth has never before appeared so agile, fresh and youthful, but more than the setting its Platinum's virtuoso coders that shine throughout, the object slicing a marvel of high-speed 3D manipulation. A technical masterpiece, Rising offers a funfair ride approximation of Konami's brooding series, but one with more than enough capacity for the Bayonetta veteran to express their dexterous expertise.
Feb 19, 2013A spectacular game on the PlayStation 3 that not only respects the previous titles but enhances the future of this genre.
Feb 19, 2013The action is always exciting and absorbing while the sword-play is refreshing, innovative and dynamic. The cut-scenes are brilliantly produced and the boss battles tense and engaging.
Feb 19, 2013Revengeance is one of the most surprising hack'n'slash titles of this generation. Years ago, nobody would have imagined a game like this within the franchise, and Platinum Games is giving us everything we wanted with it.
Feb 28, 2013The combat is faultless, the story is bonkers and the bosses some of the finest in gaming history. [Issue#228, p.66]
Mar 4, 2013Overall, Revengeance is an exciting and unique entry into the Metal Gear milieu. It's a perfect combination of Metal Gear stylings and Ninja Gaiden frenetic action.
Feb 27, 2013As if it weren't clear by the title, Metal Gear Rising: Revengeance indulges the ridiculous. This entry into the now-hallowed franchise is one of the very best.
Feb 26, 2013An exhilarating experience that beats home just what kind of masters Platinum Games are at what they do. One of the best action games in years, and one that will stay with you for a very long time.
Feb 25, 2013The game can be completed in approximately six to eight hours, depending on how quickly you master the combat and if you choose to watch the cutscenes. It may not sound like a lot but after giving your thumbs a serious work out, it's actually just the right amount of time needed to tell Raiden's story.
Feb 20, 2013Platinum identified that a world subject to infinite player Ginsu-knifing is a world without obstruction. Revengeance revives its signature sword play as the show stopper it was always meant to be, but does it in a calculated manner. The result is an action game that never overstays its welcome.
Feb 20, 2013Revengeance only falters in its overall length. There's plenty of replay value, of course, but this is one of the rare times when gameplay can't quite overcome the lack of a meaty core experience. Still, this is a game not to be missed, folks.
Feb 19, 2013For true fans this title could be a no-brainer – it's Metal Gear. More casual fans can rest easy that you really don't have to know much about the series at all to enjoy this one. Both will have to weigh if that short of a run time warrants the cost.
Feb 19, 2013For all the development trouble, for all the doubts, for all the talk about what Metal Gear Rising: Revengeance could have been – it's now a Platinum game and it sparkles with the same confidence and verve it would have done had Kojima been at the helm. It's an absolute joy to play and is almost certainly the best Metal Gear gen released this gen.
Feb 19, 2013Exactly as entertaining as you'd expect from a collaboration between two of Japan's most talented developers, and one of the best action games of the generation.
Feb 19, 2013Platinum Games has done something incredibly rare: honoring a beloved series while successfully broadening its reach into a whole new genre.
Feb 19, 2013If Revengeance didn't have camera issues this would be the easiest 10 I've ever given. As things stand it's still brilliant, staking out new territory in the genre and adapting certain Metal Gear characteristics so well that it makes the competition look outrageously bad. This is simply the ultimate one-man show, worth its ticket price many times over, an experience that improves exponentially as it gets faster and as you get better.
Apr 9, 2013Improvements need to be made, but Metal Gear Rising has already established itself to be an action game well worth buying.
Feb 19, 2013The cutting mechanic is smartly embraced as Revengeance's signature rather than its limitation, a crescendo earned by appreciating the profundity of its stylish combat. This is actually expected of Platinum, but the real surprise is their respect and dedication Metal Gear's established doctrine. By any definition, Revengeance is beautiful symmetry.
Mar 14, 2013Raiden can't block, he can only parry by swinging the left stick in the direction of an enemy and pressing square. That's right, one of the attack buttons. Raiden's motto is very simple: The best offense is a good defense. [March 2013, p.72]
Feb 19, 2013Visually amazing, intense and beautifully fast, Metal Gear Rising: Revengeance is an amazing game that will keep you on the edge of your seat. Unfortunately, the campaign of this action-packed hack 'n slash is too short.
User score distribution:
Positive: 131 out of 168
Mixed: 12 out of 168
Negative: 25 out of 168
Feb 19, 2013
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Mondays are half off on the pizza...you just have to make sure they actually apply that to the bill!!
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You're more than welcome to Edit the info or Upload a manga chapter for share. You can also keep track this manga by subscribe the RSS feed or Bookmark it.
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1997 | Yonehara Hideyuki | Yonehara Hideyuki | Action, Adventure, Comedy, Fantasy, Shounen |
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Shure SE112m+-GR Sound Isolating Earphones with Remote + Microphone Compatible with All Apple iOS Devices
"Shure SE112m+ In-Ear Headphone Review Firstly, like to thank Brad from JANDS for supplying the Shure SE112m+ to review. Packaging, Accessories and Build Quality The SE112 m+ is Shure's budget in ear headphones with mic, coming in at $105 AUD. ($59 USD) The packaging is your standard clear plastic carton, nothing too fancy. Inside..." --pformagg
Shure SE425 Earphone
"Shure has definitely outdone themselves with this wonderful product. Never have I experienced more clarity in a pair of IEMs. For someone who listens to alternative rock, pop, and an assorted array of indie music, I say that few IEMs can do better. The amount of detail displayed is extraordinary. Vocals are crystal clear and forward, especially female vocals. However, the bass is lacking a bit..." --Dinerenblanc
Sennheiser OMX 90 Style Series Clip-On Earphone with Volume Control
"The build quality of these earphones are perfect: from the very first time you hold a pair of these in your hands you know that they won't fall apart any time soon. But this build quality leads to some issues: the housing is pretty heavy and this can make the use of these clip-on styled headphones pretty uncomfortable for some people. Noise canceling isn't really good but keep in mind that this..." --Maniello
Sennheiser MX 90 Style Series In-Ear Headphone with Volume Control
"This is another well-built set of stylish earphones from Sennheiser. As they are not in-ears, noise canceling is not too good. Sound quality is still great though. The earphones have a little wheel-looking part on them which make it harder for them to fall out from your ear (and make it look pretty weird). The heads of these can be swapped for S/M/L sizes and there are other accessories for..." --Maniello
Sennheiser IE 8 In-Ear Headphones
" This is my first top tier IEM. I own it quite a long period of time. I am very happy with the SQ.... Anyway here is my review after 5 days of usage =) ( i left it in seller website) Честно говоря звук сразу после распаковки был ужасен :) Но я знал что динамическим затычкам надо время что бы 'раскрытся'. Так и произошло. Буквально через 5 часов они зазвучали значительно лучше...." --Vladimir_F1
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The CX 485 delivers the musical experience and comfort that only Sennheiser can. Using the type of transducers usually reserved for headphones costing 3x as much, the CX 485 has the detail and response you require to re-discover your music all over again. With a painstakingly crafted ergonomic design, the CX 485 fits into smaller ears for a snug yet comfortable fit you dreamed of.The unique...
Shure Sound Isolating Earphone SE315 Hi-Definition Micro Speaker with Tuned Bass Port (Black)
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High quality stereo in-ear headphone with powerful bass for listeners "on the move". Ideal for use with MP3, CD, MD, DVD and others.


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Should I wait for XP or start my MCSE for Win2k now?
If I start my MCSE for 2000 now, how will XP effect that? Will I need to retake tests to be XP certified? Should I wait and just start with XP?
The short answer to your question is that Microsoft plans to support Win2k and XP/Server .Net exams in parallel, so you can mix and match them to your heart's content.
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There's no compelling reason to wait, nor any compelling reason to focus only on Windows 2000 (except perhaps, for the very real consideration that many organizations wait a year or longer to deploy new operating systems across the board). But no, you can go ahead and start now. You don't need to wait for the new exams to become available.
For Microsoft's official statement on these subjects, please visit: http://www.microsoft.com/trainingandservices/default.asp?PageID=mcp&PageCall =faq⋐Site=cert/mcse&AnnMenu=mcse#3title
The title of this portion of the MCSE FAQ is "Frequently Asked Questions about Windows XP Professional and Windows .Net Server Exams" so you know it speaks directly to your concerns.
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Robert Pattinson Reportedly Sexed Up A New Girl When Kristen Stewart Cheated On Him
Robert Pattinson reportedly sexed up a new girl when Kristen Stewart cheated on him. Hollywood Life is now reporting that they've spoken with a new chick,who claims she sexed up Robert Pattinson last summer after he found out that his main chick Kristen Stewart cheated on him. In addition to that,she thought Rob was the bomb in bed,rating him a perfect 10,and more. The girl insisted on keeping her name private. Shocker.
However, she claimed, "I hooked-up with Rob twice last summer and I'd give him a 10 for sure. He's a great kisser and really sweet, but he still totally knows how to take charge. We were drinking a lot both times but he had no problems in the bedroom, we stayed up almost all night the first time."
After that, she went on to claim that Rob treated her with a caring attitude even though they both new it was a one night stand,stating, "He was smoking and since I don't smoke he was really self conscious about his breath and he kept running to the bathroom to use the mouthwash. I told him it was totally fine but it was still nice that he cared so much. We both knew it was never going to be anything serious but Rob never made me feel cheap. The whole thing was as good as you'd imagine. I'd love to see him again."
To cap off the article, they also said they spoke with another,supposed ex-lover of Rob's,and she backed up the previous girl's claims,stating, Rob was "amazing in bed." Stay tuned. Follow us on Facebook by Clicking Here. Follow us on Twitter by Clicking Here.
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Archive through January 29, 2006 Forum
4 volt pre-outputs: does this make it a GREAT head unit?
Sean Gibson
Silver Member
Username: Phuktupbasshead
Scottsdale, Arizona United State...
Post Number: 368
Registered: May-05
Posted on
Tuesday, January 03, 2006 - 12:22 GMT
At Audio Express, I almost spent $400.00
I'm supposed to go there in 3 hrs to buy a head unit... I was looking at the Alpine's, but the guy told me the Premiere's were the "cream of the crop".
When I asked how to know if the headunit was the s,h,i,t -
He said,
"If it has a 4 volt pre-out, then it's the s,h,i,t! You see, the 4 volt pre-out enables the stereo to deliver..." blah, blah, blah.
Is there any truth to that? Can someone help me out so I don't get phuked over by this salesman? Then again, he could actually be a GREAT salesman... problem is, I have NO IDEA!!!
I have various questions:
1. What makes a good HU?
2. What difference does the 4 v pre-out make?
3. 4 v pre-out = "upper" bracket of quality?
4. What are the most affordable models on HU's in that "upper" bracket of quality?
5. How much do those affordable models in the "upper" bracket actually cost?
Thanks for reading, everyone... please help!
I really appreciate this one!!!!!!!!!!!!
ty mutlow
Silver Member
Username: Tjmutlow
Post Number: 811
Registered: Sep-05
Posted on
Tuesday, January 03, 2006 - 13:23 GMT
what head unit did you buy? and the higher pre out voltage the better, If you got the 770 it was 2 much for 400, warranty issue aside, that unit is 200 on ebay and the 860 unit has 6.5v pre outs and is only around 350. Look at the eclipse and panasonic(they hve 5volt prouts) and eclipse high end units are 8volts.
ty mutlow
Silver Member
Username: Tjmutlow
Post Number: 812
Registered: Sep-05
Posted on
Tuesday, January 03, 2006 - 13:28 GMT
take a look at this unit, it is really really nice and around 400 refurbeed from pioneer with warranty.DEH-P90HDD
CD/MP3/Memory Stick Player - 10 GB Hard Drive
Suggested Price: $2,100.00
(2198 KB, 314 sec @56k)
(284 KB, 41 sec @56k)
Close Up Front View
Close Up of Remote Control
Supertuner III
24-Station/6-Button (18FM/6AM) Presets
BSM (Best Stations Memory)
CD Player
1-bit D/A Converter 8fs/20-bit
CD-R/CD-RW Compatible
AGC (Automatic Gain Control)
Disc Title Memory
Track Title List
CD Text Y
Audio Features
Built-in Speaker Power Y
Equalizer 13-Band
Auto-EQ (With Mic Included)
Listening Position Selector
BBE Digital
Automatic Sound Levelizer (ASL)
Electronic Balance/Fader
Source Level Adjuster (SLA)
High-Pass Crossover (HPF) Y
Subwoofer Crossover (LPF) Y
General Features
10GB HDD (CDDB Preinstalled)
MagicGate Memory Stick Player
ATRAC3 Encode/Decode
Rotary Volume Control Pop-Up
Remote Control Steering Wheel
Cellular Mute
Detachable Face Security
Face Case (Included)
Warranty 1 Year
Premier Service and Installation
Gold Member
Username: Illuminator
Post Number: 2434
Registered: Apr-05
Posted on
Tuesday, January 03, 2006 - 13:52 GMT
A headunit's pre-out voltage alone is a bad way to judge how nice it is.
* Rovin *
Gold Member
Username: Rovin
Trinidad & T...
Post Number: 4447
Registered: Jul-05
Posted on
Tuesday, January 03, 2006 - 16:41 GMT
pre-out voltage is a major factor when choosing
but of course also u must like the layout of bottons (ease of use) ,features , product reputation based on reading alot of reviews & price ........
Gold Member
Username: Illuminator
Post Number: 2436
Registered: Apr-05
Posted on
Tuesday, January 03, 2006 - 20:10 GMT
Most head units now vary between 2-6v with 4v being standard. I don't see how it's a major decision...
What is important, however, is the RCA output impedence, but that's another story...
Platinum Member
Username: Glasswolf
Wisteria, Lane USA
Post Number: 10871
Registered: Dec-03
Posted on
Friday, January 06, 2006 - 19:08 GMT
4 volt pre-outs have higher resolution than lower voltage pre-outs.
this translates to a cleaner, more detailed signal at the amplifier input stage for a cleaner audio reproduction.
Silver Member
Username: Vinnyqh
Portland, OR
Post Number: 141
Registered: Nov-05
Posted on
Friday, January 06, 2006 - 20:38 GMT
i woudln't really say that 4volt is standard. you have to get into the upper 3/4 of the headunits to get 4volt or higher now, most are 2.2 volt.
Sean Gibson
Silver Member
Username: Phuktupbasshead
Scottsdale, Arizona United State...
Post Number: 370
Registered: May-05
Posted on
Saturday, January 07, 2006 - 02:41 GMT
(Now i'm REALLY interested)
Keep talking you guys, I'm soaking all this up!!!
What DOES make a good head unit?
Should I go for more than 4volts?
Know of any affordable ones?
You guys are awesome.
Thanks again for reading.
Thanks again.
Sean Gibson
Silver Member
Username: Phuktupbasshead
Scottsdale, Arizona United State...
Post Number: 373
Registered: May-05
Posted on
Saturday, January 07, 2006 - 03:02 GMT
Now we're talking! Keep going guys... I'm soaking all this up!!!
You guys truely are awesome. I wanna know more.
Keep talking, keep talking!!!!
Which ones of these SPECTACULAR HU's are the best for the $$$?
Unregistered guest
Posted on
Tuesday, January 10, 2006 - 20:01 GMT
features I looked for when buying my most recent headunit
-3 sets of preouts: front, rear, and subwoofer (4volt minimum)
-auxilliary rca input: easy to hook up my mp3 player
-brand reliability/reviews
-signal to noise ratio
In the end I narrowed it to 3 headunits, then bought the one I could get the best deal for on ebay.
I ended up with the kenwood x789 for under 200 shipped.
Gold Member
Username: Illuminator
Post Number: 2462
Registered: Apr-05
Posted on
Tuesday, January 10, 2006 - 20:11 GMT
I wouldn't trust reviews. People can be pretty stupid when it comes to car audio, and they blame it on the product itself the majority of the time. Also, the reviewers need experience. A reviewer who has only owned Radioshack might be massively impressed with a Sony, whereas a reviewer who has only owned Alpine might be massively unhappy with the same Sony. Additionally, reviews are overall performance/price/ease of use. You might just want something with good performance regardless of price-ruling reviews useless.
Signal to noise ratio wouldn't make much of an audible difference in modern headunits-unless you're comparing a RadioShack to an Alpine.
* Rovin *
Gold Member
Username: Rovin
Trinidad & T...
Post Number: 4613
Registered: Jul-05
Posted on
Tuesday, January 10, 2006 - 20:34 GMT
well i like my premier 860 which replaced a Jvc i had b4 . Jvc preout was standard 2.2 & with this 6.5v on the Premier it sounded so much livelier & vol knob did not need turning up as much . The Jvc is not crap by any means ,in fact i liked it alot .
This HU was the best i could find with what i wanted @ the time $340 shipped - has all the bells/whistles but some features could have been more easier accessable but then again with so many features they have to make it so that a few buttons must be pressed .
Display in full sunlight is a tad under but how often will it be in the sun . No complaints @ night though . When i recently did my install i didn't really need to use this deck's 13 band EQ because its clean enough but the feature is handy for personal tastes ....but overall really good deck imo .......
Sean Gibson
Silver Member
Username: Phuktupbasshead
Scottsdale, Arizona United State...
Post Number: 379
Registered: May-05
Posted on
Sunday, January 15, 2006 - 05:45 GMT
right on...
thanks for the input.
what do you know about eclipse head units?
I've heard good things about them, but I get the impression that they're really expensive.
How do they compare against the Pioneer Premiers mentioned above?
Also, I really appreciate your guys' help.
Any and all input is still alot of help! Keep talking, I'm listening!!!!!!!!!!!
Sean Gibson
Silver Member
Username: Phuktupbasshead
Scottsdale, Arizona United State...
Post Number: 381
Registered: May-05
Posted on
Tuesday, January 17, 2006 - 06:16 GMT
Rovin, have you ever had experience with the Kenwood head units that flip over when turned off to deter theft? I was wondering if they are exceptional as well, or if it's just a cosmetic feature to make up for its lack of sound quality/production.
Valid question from a headunit noobie to a vet like yourself, right?
thanks, man.
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