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| nitric oxideSummarySummary: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. Top Publications
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- Nitric oxide and peroxynitrite in health and diseasePal Pacher
Section on Oxidative Stress Tissue Injury, Laboratory of Physiologic Studies, National Institutes of Health, National Institute of Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA
Physiol Rev 87:315-424. 2007The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide (NO) has stimulated an extraordinary impetus for scientific research in all the fields of biology and medicine... - Nitric oxide synthases: regulation and functionUlrich Förstermann
Department of Pharmacology, Johannes Gutenberg University Medical Center, 55101 Mainz, Germany
Eur Heart J 33:829-37, 837a-837d. 2012b>Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 184.108.40.206)... - Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxideGuangwen Ren
Department of Molecular Genetics, Microbiology and Immunology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 661 Hoes Lane, Piscataway, NJ 08854, USA
Cell Stem Cell 2:141-50. 2008..These cytokine combinations provoke the expression of high levels of several chemokines and inducible nitric oxide synthase (iNOS) by MSCs... - Nitric oxide and the immune responseC Bogdan
Institute of Clinical Microbiology, Immunology and Hygiene, Friedrich Alexander University of Erlangen Nuremberg, Wasserturmstrasse 3 5, D 91054 Erlangen, Germany
Nat Immunol 2:907-16. 2001During the past two decades, nitric oxide (NO) has been recognized as one of the most versatile players in the immune system... - Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task ForceMary C Corretti
Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21205 1595, USA
J Am Coll Cardiol 39:257-65. 2002..The technique provokes the release of nitric oxide, resulting in vasodilation that can be quantitated as an index of vasomotor function... - Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylationS Dimmeler
Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
Nature 399:601-5. 1999b>Nitric oxide (NO) produced by the endothelial NO synthase (eNOS) is a fundamental determinant of cardiovascular homesotasis: it regulates systemic blood pressure, vascular remodelling and angiogenesis... - Role of endothelial dysfunction in atherosclerosisJean Davignon
Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, 110 Pine Ave W, Montreal, QC H2W 1R7, Canada
Circulation 109:III27-32. 2004..Many of these effects are largely mediated by nitric oxide, the most potent endogenous vasodilator... - Nitric oxide synthases: structure, function and inhibitionW K Alderton
In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
Biochem J 357:593-615. 2001This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in our understanding of this enzyme family... - The L-arginine-nitric oxide pathwayS Moncada
Wellcome Research Laboratories, Beckenham, Kent, United Kingdom
N Engl J Med 329:2002-12. 1993 - Endothelial nitric oxide synthase in vascular disease: from marvel to menaceUlrich Förstermann
Department of Pharmacology, Johannes Gutenberg University, Mainz, Germany
Circulation 113:1708-14. 2006b>Nitric oxide (NO*) is an important protective molecule in the vasculature, and endothelial NO* synthase (eNOS) is responsible for most of the vascular NO* produced... - Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1βBibhuti B Mishra
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 14:52-60. 2013..This effect was mediated by nitric oxide (NO), which we found specifically inhibited assembly of the NLRP3 inflammasome via thiol nitrosylation... - Protein S-nitrosylation: purview and parametersDouglas T Hess
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Rev Mol Cell Biol 6:150-66. 2005..S-nitrosylation thereby conveys a large part of the ubiquitous influence of nitric oxide (NO) on cellular signal transduction, and provides a mechanism for redox-based physiological regulation. - Biochemical and functional characterization of three activated macrophage populationsJustin P Edwards
Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
J Leukoc Biol 80:1298-307. 2006..These are sphingosine kinase-1 and LIGHT (TNF superfamily 14). Thus, Ca-Mphi, Mphi-II, and AA-Mphi represent three populations of cells with different biological functions... - Nitric oxide and superoxide in inflammation and immune regulationT J Guzik
Chair of Pharmacology, Jagiellonian University School of Medicine, Poland
J Physiol Pharmacol 54:469-87. 2003b>Nitric oxide (NO) and reactive oxygen species exert multiple modulating effects on inflammation and play a key role in the regulation of immune responses. They affect virtually every step of the development of inflammation... - Regulation of endothelium-derived nitric oxide production by the protein kinase AktD Fulton
Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536, USA
Nature 399:597-601. 1999Endothelial nitric oxide synthase (eNOS) is the nitric oxide synthase isoform responsible for maintaining systemic blood pressure, vascular remodelling and angiogenesis... - Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and diseaseMiriam M Cortese-Krott
Cardiovascular Research Laboratory, Department of Cardiology, Pulmonology and Angiology, Heinrich Heine University of Dusseldorf, 40225 Dusseldorf, Germany
Blood 120:4229-37. 2012A nitric oxide synthase (NOS)-like activity has been demonstrated in human red blood cells (RBCs), but doubts about its functional significance, isoform identity and disease relevance remain... - Protein S-nitrosylation in health and disease: a current perspectiveMatthew W Foster
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Trends Mol Med 15:391-404. 2009Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on cellular signal transduction and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad .. - Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovaniH W Murray
Department of Medicine, Division of Hematology Oncology, Cornell University Medical College, New York 10021, USA
J Exp Med 189:741-6. 1999..respiratory burst-deficient gp91(phox)-/- (X-linked chronic granulomatous disease [X-CGD]) mice and inducible nitric oxide synthase (iNOS) knockout (KO) mice displayed comparably increased susceptibility... - Nitric oxide and oxidative stress in vascular diseaseUlrich Förstermann
Department of Pharmacology, Johannes Gutenberg University Medical Center, Obere Zahlbacher Strasse 67, 55101, Mainz, Germany
Pflugers Arch 459:923-39. 2010Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone, inhibits platelet function, prevents adhesion of leukocytes, and reduces proliferation of the intima... - cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP actionSharron H Francis
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 2215 Garland Avenue, Nashville, TN 37232 0615, USA
Pharmacol Rev 62:525-63. 2010To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs)... - Arginine metabolism: nitric oxide and beyondG Wu
Departments of Animal Science, Medical Physiology, and Veterinary Anatomy and Public Health, and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
Biochem J 336:1-17. 1998..amino acids in animal cells, serving as a precursor for the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline, glutamate, creatine and agmatine... - The nitrate-nitrite-nitric oxide pathway in physiology and therapeuticsJon O Lundberg
Department of Physiology and Pharmacology, Karolinska Institute, SE 171 77 Stockholm, Sweden
Nat Rev Drug Discov 7:156-67. 2008..anions nitrate (NO3-) and nitrite (NO2-) were previously thought to be inert end products of endogenous nitric oxide (NO) metabolism... - Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generationMatthias Totzeck
Department of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, University Hospital Duesseldorf, Germany
Circulation 126:325-34. 2012..We have shown that deoxygenated myoglobin in the heart can reduce nitrite to nitric oxide (NO·) and thereby contribute to cardiomyocyte NO· signaling during ischemia... - S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegenerationTakashi Uehara
Center for Neuroscience and Aging, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 441:513-7. 2006..manifesting sporadic Parkinson's or Alzheimer's disease, that PDI is S-nitrosylated, a reaction transferring a nitric oxide (NO) group to a critical cysteine thiol to affect protein function... - Adiponectin stimulates production of nitric oxide in vascular endothelial cellsHui Chen
Diabetes Unit, Laboratory of Clinical Investigation, NCCAM, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 278:45021-6. 2003..The vascular action of insulin to stimulate endothelial production of nitric oxide (NO), leading to vasodilation and increased blood flow is an important component of insulin-stimulated whole .. - Nitric oxide is required for root organogenesisGabriela Carolina Pagnussat
Instituto de Investigaciones Biologicas, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, 7600 Mar del Plata, Argentina
Plant Physiol 129:954-6. 2002 - Molecular hydrogen inhibits lipopolysaccharide/interferon γ-induced nitric oxide production through modulation of signal transduction in macrophagesTomohiro Itoh
Department of Longevity and Aging Research, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
Biochem Biophys Res Commun 411:143-9. 2011..In the present study, we examined the hydrogen effects on lipopolysaccharide/interferon γ LPS/IFNγ-induced nitric oxide (NO) production in murine macrophage RAW264 cells... - Uric acid-induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cellsDuk Hee Kang
Division of Nephrology, Ewha Women s University Hospital, Seoul, Korea
J Am Soc Nephrol 16:3553-62. 2005..UA also increased HVSMC migration and inhibited HUVEC migration. In HUVEC, UA reduced nitric oxide (NO) release... - ABA-induced NO generation and stomatal closure in Arabidopsis are dependent on H2O2 synthesisJo Bright
Centre for Research in Plant Science, Genomics Research Institute, University of the West of England, UWE, Bristol, Frenchay Campus, Coldharbour Lane, UK
Plant J 45:113-22. 2006b>Nitric oxide (NO) and hydrogen peroxide (H(2)O(2)) are key signalling molecules produced in response to various stimuli and involved in a diverse range of plant signal transduction processes... - Arginase: a critical regulator of nitric oxide synthesis and vascular functionWilliam Durante
Department of Medical Pharmacology and Physiology, University of Missouri Columbia, Columbia, Missouri 65212, USA
Clin Exp Pharmacol Physiol 34:906-11. 2007..studies have identified arginase in the vasculature and have implicated this enzyme in the regulation of nitric oxide (NO) synthesis and the development of vascular disease. 2... - Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shockKairui Mao
State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Cell Res 23:201-12. 2013..Here we show that nitric oxide (NO) inhibited the NLRP3-mediated ASC pyroptosome formation, caspase-1 activation and IL-1β secretion in .. - miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide productionAna L Cardoso
Centre for Neuroscience and Cell Biology, University of Coimbra, Portugal
Immunology 135:73-88. 2012..oligonucleotides up-regulated SOCS-1 mRNA and protein levels and significantly decreased the production of nitric oxide and the expression of inflammatory cytokines and inducible nitric oxide synthase... - Roles of hydrogen sulfide and nitric oxide in the alleviation of cadmium-induced oxidative damage in alfalfa seedling rootsLe Li
College of Life Sciences, Cooperative Demonstration Laboratory of Centrifuge Technique of Nanjing Agricultural University and Beckman Coulter Ltd Co, Nanjing 210095, People s Republic of China
Biometals 25:617-31. 2012Despite hydrogen sulfide (H(2)S) and nitric oxide (NO) are important endogenous signals or bioregulators involved in many vital aspects of plant growth and responses against abiotic stresses, little information was known about their .. - Concepts of neural nitric oxide-mediated transmissionJohn Garthwaite
Wolfson Institute for Biomedical Research, University College London, Gower Street, London WCIE 6BT, UK
Eur J Neurosci 27:2783-802. 2008As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the nervous system, predating many of the more .. - Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulationKenyatta Cosby
Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B15 Bethesda, Maryland 20892, USA
Nat Med 9:1498-505. 2003Nitrite anions comprise the largest vascular storage pool of nitric oxide (NO), provided that physiological mechanisms exist to reduce nitrite to NO... - Mitochondrial biogenesis in mammals: the role of endogenous nitric oxideEnzo Nisoli
Department of Preclinical Sciences, Center for Study and Research on Obesity, Luigi Sacco Hospital, University of Milan, Milan 20157, Italy
Science 299:896-9. 2003b>Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocytes and 3T3-L1, U937, and HeLa cells... - β Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthaseKuo Hui Su
Department of Physiology, National Yang Ming University, Taipei, Taiwan
J Cell Physiol 226:3330-9. 2011Erythropoietin (EPO), the key hormone for erythropoiesis, also increases nitric oxide (NO) bioavailability in endothelial cells (ECs), yet the definitive mechanisms are not fully understood... - Nitric oxide signaling in brain function, dysfunction, and dementiaJoern R Steinert
Neurotoxicity at the Synaptic Interface, MRC Toxicology Unit, University of Leicester, Leicester, UK
Neuroscientist 16:435-52. 2010b>Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous system... - Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodesVeronika Lukacs-Kornek
Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Nat Immunol 12:1096-104. 2011..we report that FRCs and LECs inhibited T cell proliferation through a tightly regulated mechanism dependent on nitric oxide synthase 2 (NOS2)... - Nitric oxide signaling: classical, less classical, and nonclassical mechanismsAntonio Martínez-Ruiz
Servicio de Inmunologia, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid, Spain
Free Radic Biol Med 51:17-29. 2011Although nitric oxide (NO) was identified more than 150 years ago and its effects were clinically tested in the form of nitroglycerine, it was not until the decades of 1970-1990 that it was described as a gaseous signal transducer... - Phylogenetic analysis of nitrite, nitric oxide, and nitrous oxide respiratory enzymes reveal a complex evolutionary history for denitrificationChristopher M Jones
Department of Microbiology, Swedish Agricultural University, Uppsala, Sweden
Mol Biol Evol 25:1955-66. 2008Denitrification is a facultative respiratory pathway in which nitrite (NO2(-)), nitric oxide (NO), and nitrous oxide (N2O) are successively reduced to nitrogen gas (N(2)), effectively closing the nitrogen cycle... - Nitric oxide, stomatal closure, and abiotic stressSteven Neill
Centre for Research in Plant Science, Faculty of Health and Life Sciences, University of the West of England, Bristol BS16 1QY, UK
J Exp Bot 59:165-76. 2008Various data indicate that nitric oxide (NO) is an endogenous signal in plants that mediates responses to several stimuli... - High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanismsYung Hsiang Chen
School of Medicine, National Yang Ming University, Taipei City, Taiwan
Diabetes 56:1559-68. 2007..Endothelial progenitor cells (EPCs) are impaired in diabetes. This study aimed to investigate the direct effects of high glucose on EPCs... - The role of nitric oxide in tumour progressionDai Fukumura
Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Nat Rev Cancer 6:521-34. 2006b>Nitric oxide (NO) and nitric oxide synthases are ubiquitous in malignant tumours and are known to exert both pro- and anti-tumour effects... - Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cellsNikki Charles
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cell Stem Cell 6:141-52. 2010..We investigated the potential role of nitric oxide (NO) activity in the perivascular niche (PVN) using a genetic engineered mouse model of PDGF-induced gliomas... - Multiple defects of immune cell function in mice with disrupted interferon-gamma genesD K Dalton
Genentech Inc, South San Francisco, CA 94080
Science 259:1739-42. 1993..Resting splenic natural killer cell activity was reduced in IFN-gamma-deficient mice. Thus, IFN-gamma is essential for the function of several cell types of the murine immune system... - Role of nitric oxide in the regulation of digital pulse volume amplitude in humansAnju Nohria
Cardiovascular Div, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
J Appl Physiol (1985) 101:545-8. 2006..PVA) during reactive hyperemia relative to baseline (PVA-RH) is being applied widely as a convenient test of nitric oxide bioavailability. However, evidence linking digital PVA-RH to nitric oxide is currently lacking... - Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1Lisa A Ridnour
Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
J Neurochem 123:736-49. 2012..Regulation of MMP-9 and its endogenous inhibitor tissue inhibitor of metalloproteinase (TIMP)-1 by nitric oxide (NO) has been shown... - Hydrogen peroxide and nitric oxide as signalling molecules in plantsSteven J Neill
Centre for Research in Plant Science, Faculty of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, UK
J Exp Bot 53:1237-47. 2002It is now clear that hydrogen peroxide (H(2)O(2)) and nitric oxide (NO) function as signalling molecules in plants. A wide range of abiotic and biotic stresses results in H(2)O(2) generation, from a variety of sources... - Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilationMark T Gladwin
Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
Am J Physiol Heart Circ Physiol 291:H2026-35. 2006..salt, nitrite (NO(2)(-)), is a physiological signaling molecule with potential roles in intravascular endocrine nitric oxide (NO) transport, hypoxic vasodilation, signaling, and cytoprotection after ischemia-reperfusion... - Nitric oxide influences auxin signaling through S-nitrosylation of the Arabidopsis TRANSPORT INHIBITOR RESPONSE 1 auxin receptorMaría C Terrile
Instituto de Investigaciones Biologicas, UE CONICET UNMDP, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, Funes 3250, CC 1245, 7600 Mar del Plata, Argentina
Plant J 70:492-500. 2012Previous studies have demonstrated that auxin (indole-3-acetic acid) and nitric oxide (NO) are plant growth regulators that coordinate several plant physiological responses determining root architecture... - On the origins of nitric oxideKapuganti J Gupta
Energy Metabolism Research Group, Max Planck Institute of Molecular Plant Physiology, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
Trends Plant Sci 16:160-8. 2011b>Nitric oxide (NO) is widely recognized for its role as signaling compound... - Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxationCiro Coletta
Department of Anesthesiology, University of Texas Medical Branch and Shriners Burns Hospital for Children, Galveston, TX 77555, USA
Proc Natl Acad Sci U S A 109:9161-6. 2012..vascular actions of H(2)S (stimulation of angiogenesis, relaxation of vascular smooth muscle) resemble those of nitric oxide (NO)... - The role of nitric oxide in innate immunityC Bogdan
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Germany
Immunol Rev 173:17-26. 2000Type 2 nitric oxide synthase (iNOS or NOS2) was originally described as an enzyme that is expressed in activated macrophages, generates nitric oxide (NO) from the amino acid L-arginine, and thereby contributes to the control of .. - Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospectsPeter Wardman
University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
Free Radic Biol Med 43:995-1022. 2007..species include hydrogen peroxide; hydroxyl, superoxide, and thiyl radicals; carbonate radical-anion; and nitric oxide, nitrogen dioxide, and peroxynitrite... - Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respirationSruti Shiva
Vascular Medicine Branch, Clinical Center National Institutes of Health, Bethesda, MD 20892 1662, USA
Circ Res 100:654-61. 2007Previous studies have revealed a novel interaction between deoxyhemoglobin and nitrite to generate nitric oxide (NO) in blood... - Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: a double-blind, randomised controlled trialHeather Powell
Centre for Asthma and Respiratory Diseases, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia
Lancet 378:983-90. 2011..counts reduce exacerbations in non-pregnant women with asthma, but results with the fraction of exhaled nitric oxide (F(E)NO) to guide management are equivocal... - PGC-1α promotes nitric oxide antioxidant defenses and inhibits FOXO signaling against cardiac cachexia in miceTuoyu Geng
Department of Medicine Cardiovascular Medicine, University of Virginia, Charlottesville, VA 22908, USA
Am J Pathol 178:1738-48. 2011..kinase B expression, in glycolytic muscles, PGC-1α overexpression led to enhanced expression of inducible nitric oxide synthase and endothelial nitric oxide synthase, production of nitric oxide, and expression of antioxidant .. - Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxideIvraym B Barsoum
Department of Anatomy and Cell Biology, Queen s University, Kingston, Ontario, Canada
Cancer Res 71:7433-41. 2011..b>Nitric oxide mimetic agents interfered with the hypoxia-induced accumulation of HIF-1α and with the hypoxia-induced .. - Connecting the chemical and biological properties of nitric oxideJosé Carlos Toledo
Departamento de Quimica, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
Chem Res Toxicol 25:975-89. 2012b>Nitric oxide (NO(•); nitrogen monoxide) is known to be a critical regulator of cell and tissue function through mechanisms that utilize its unique physicochemical properties as a small and uncharged free radical with limited reactivity... - Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARBMaristela Lika Onozato
Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
Kidney Int 61:186-94. 2002..adenine dinucleotide phosphate [NAD(P)H] oxidase, whose product superoxide anion (O2-) can interact with nitric oxide (NO) to form peroxynitrite (ONOO-)... - Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen speciesBrian P Dranka
Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
Free Radic Biol Med 48:905-14. 2010..These data are consistent with a critical role for the mitochondrial reserve capacity in endothelial cells in responding to oxidative stress... - Nitric oxide and neuronal deathGuy C Brown
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom
Nitric Oxide 23:153-65. 2010..iNOS is induced in glia by inflammation, and may protect; however, if there is also hypoxia or the NADPH oxidase is active, it can induce neuronal death. Microglial phagocytosis may contribute actively to neuronal loss... - Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylationPeter F Mount
Department of Nephrology, Austin Health, Studley Road, Heidelberg 3084, Victoria, Australia
J Mol Cell Cardiol 42:271-9. 2007The controlled regulation of nitric oxide (NO) synthesis in endothelial cells and cardiomyocytes by the endothelial form of nitric oxide synthase (eNOS or NOS3) is essential for cardiovascular health... - Intake of red wine increases the number and functional capacity of circulating endothelial progenitor cells by enhancing nitric oxide bioavailabilityPo Hsun Huang
Division of Cardiology, Taipei Veterans General Hospital, Taipei, Taiwan
Arterioscler Thromb Vasc Biol 30:869-77. 2010..This study tested the hypothesis that intake of RW may promote the circulating endothelial progenitor cell (EPC) level and function through enhancement of nitric oxide bioavailability. - High-yield isolation of murine microglia by mild trypsinizationJosep Saura
Department of Pharmacology and Toxicology, Institut d Investigacions Biomediques de Barcelona, IIBB CSIC, Barcelona, Spain
Glia 44:183-9. 2003..Because of its high yield, it can be especially convenient when high amounts of microglial protein/mRNA are required or in cases in which the starting material is limited, such as microglial cultures from transgenic animals... - Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase couplingCharalambos Antoniades
Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital OX3 9DU, Oxford, UK
Circulation 124:335-45. 2011..We examined the direct effects of atorvastatin on tetrahydrobiopterin-mediated endothelial nitric oxide (NO) synthase coupling in patients with coronary artery disease. - Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductaseBarbara Wegiel
Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 108:18849-54. 2011..BV) quells the cellular response to endotoxin-induced inflammation through phosphorylation of endothelial nitric oxide synthase (eNOS)... - S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 bindingMakoto R Hara
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Nat Cell Biol 7:665-74. 2005..Here we report a signalling pathway in which nitric oxide (NO) generation that follows apoptotic stimulation elicits S-nitrosylation of GAPDH, which triggers binding to .. - Methods of nitric oxide detection in plants: a commentaryLuis A J Mur
University of Wales, Aberystwyth, Institute of Biological Sciences, Aberystwyth, Wales, UK
Plant Sci 181:509-19. 2011Over the last decade nitric oxide (NO) has been shown to influence a range of processes in plants. However, when, where and even if NO production occurs is controversial in several physiological scenarios in plants... - Reactive oxygen species, antioxidant systems and nitric oxide in peroxisomesLuis A del Rio
Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, CSIC, Apartado 419, E 18080 Granada, Spain
J Exp Bot 53:1255-72. 2002..for peroxisomes related to reactive oxygen species (ROS), but the recent demonstration of the presence of nitric oxide synthase (NOS) in plant peroxisomes implies that these organelles could also have a function in plant cells as .. - Interleukin-33 induces angiogenesis and vascular permeability through ST2/TRAF6-mediated endothelial nitric oxide productionYeon Sook Choi
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea
Blood 114:3117-26. 2009..Ligation of IL-33 with ST2 rapidly increased endothelial nitric oxide (NO) production through TRAF6-mediated activation of phosphoinoside-3-kinase, Akt, and endothelial NO synthase... - Reactive oxygen and reactive nitrogen intermediates in innate and specific immunityC Bogdan
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen, Erlangen, D 91054, Germany
Curr Opin Immunol 12:64-76. 2000b>Nitric oxide, nitric oxide derivatives and reactive oxygen intermediates are toxic molecules of the immune system which contribute to the control of microbial pathogens and tumors... - Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthaseZ Huang
Stroke Research Laboratory, Massachusetts General Hospital, Charlestown 02129
Science 265:1883-5. 1994The proposal that nitric oxide (NO) or its reactant products mediate toxicity in brain remains controversial in part because of the use of nonselective agents that block NO formation in neuronal, glial, and vascular compartments... - Nitric oxide, oxidants, and protein tyrosine nitrationRafael Radi
Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
Proc Natl Acad Sci U S A 101:4003-8. 2004.... - Plasma sodium stiffens vascular endothelium and reduces nitric oxide releaseHans Oberleithner
Institute of Physiology II and Department of Internal Medicine D, University of Munster, 48149 Munster, Germany
Proc Natl Acad Sci U S A 104:16281-6. 2007..b>Nitric oxide formation was found down-regulated in cells cultured in aldosterone-containing high sodium medium... - The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine responseP C Melby
Medical Service, Department of Veterans Affairs Medical Center, South Texas Veterans Health Care System, San Antonio, TX 78284, USA
J Immunol 166:1912-20. 2001..Thus, although a Th1-like cytokine response was prominent, the major antileishmanial effector mechanism that is responsible for control of infection in mice was absent throughout the course of progressive VL in the hamster... - Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidaseG C Brown
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK
Biochim Biophys Acta 1504:46-57. 2001b>Nitric oxide (NO) and its derivatives inhibit mitochondrial respiration by a variety of means... - Production of nitric oxide by glial cells: regulation and potential roles in the CNSS Murphy
Department of Pharmacology and the Neuroscience Program, University of Iowa College of Medicine, Iowa City, USA
Glia 29:1-13. 2000Roles proposed for nitric oxide (NO) in CNS pathophysiology are increasingly diverse and range from intercellular signaling, through necrotic killing of cells and invading pathogens, to the involvement of NO in apoptosis and tissue .. - Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old ratsJae Hyung Kim
Anesthesiology, Tower 711, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
J Appl Physiol (1985) 107:1249-57. 2009..In this study, we demonstrate that arginase upregulation leads to endothelial nitric oxide synthase (eNOS) uncoupling and that in vivo chronic inhibition of arginase restores nitroso-redox balance, .. - Endothelial function: a critical determinant in atherosclerosis?Ulf Landmesser
Medizinische Hochschule Hannover, Abteilung Kardiologie und Angiologie, Carl Neuberg Str 1, 30625 Hannover, Germany
Circulation 109:II27-33. 2004..An important rationale for this approach has been the observation that endothelium-derived nitric oxide (NO), a major mediator of endothelium-dependent vasodilation, has important anti-inflammatory and .. - A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesisSubodh Verma
Division of Cardiac Surgery, Toronto General Hospital, University of Toronto, Toronto, Canada
Circulation 106:913-9. 2002Given the central importance of nitric oxide (NO) in the development and clinical course of cardiovascular diseases, we sought to determine whether the powerful predictive value of C-reactive protein (CRP) might be explained through an .. - Mechanisms underlying endothelial dysfunction in diabetes mellitusU Hink
Universitatskrankenhaus Eppendorf, Germany
Circ Res 88:E14-22. 2001..endothelial cells in vitro with high concentrations of glucose activates protein kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as superoxide production. The underlying mechanisms remain unknown... - Globular adiponectin improves high glucose-suppressed endothelial progenitor cell function through endothelial nitric oxide synthase dependent mechanismsPo Hsun Huang
Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
J Mol Cell Cardiol 51:109-19. 2011..that globular adiponectin can improve high glucose-suppressed EPC functions by restoration of endothelial nitric oxide synthase (eNOS) activity. Late EPCs isolated from healthy subjects appeared with cobblestone shape at 2-4 weeks... - Dose-dependent modulatory effects of insulin on glucose-induced endothelial senescence in vitro and in vivo: a relationship between telomeres and nitric oxideHisako Matsui-Hirai
Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
J Pharmacol Exp Ther 337:591-9. 2011..of insulin under high-glucose conditions was associated with reduced reactive oxygen species and increased nitric oxide (NO). Small interfering RNA targeting endothelial NO synthase reduced the antisenescence effects of insulin... - Nitric reductase-dependent nitric oxide production is involved in cold acclimation and freezing tolerance in ArabidopsisMin Gui Zhao
State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, People s Republic of China
Plant Physiol 151:755-67. 2009b>Nitric oxide (NO) is an important signaling molecule involved in many physiological processes in plants... - Nitric oxide: role in tumour biology and iNOS/NO-based anticancer therapiesSimendra Singh
Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, Gautam Budha Nagar 201306, India
Cancer Chemother Pharmacol 67:1211-24. 2011The diatomic radical nitric oxide (NO) has been the cause of intense debate with implication in carcinogenesis, tumour progression, invasion, angiogenesis and modulation of therapeutic responses... - eNOS, metabolic syndrome and cardiovascular diseasePaul L Huang
Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Trends Endocrinol Metab 20:295-302. 2009..This review focuses on endothelial nitric oxide synthase and summarizes evidence that a reduction in the bioavailability of endothelium-derived nitric oxide .. - Effect of exercise training on endothelium-derived nitric oxide function in humansDaniel J Green
School of Human Movement and Exercise Science, University of Western Australia, Mailbag Delivery M408, 35 Stirling Highway, Crawley WA 6009, Australia
J Physiol 561:1-25. 2004..These functions are due to the production of numerous autacoids, of which nitric oxide (NO) has been the most widely studied... - Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharideGi Su Oh
Department of Microbiology and Immunology and Medicinal Resources Research Institute, Wonkwang University School of Medicine, Iksan, Chonbuk 570 749, Republic of Korea
Free Radic Biol Med 41:106-19. 2006..beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored... - Redox regulation of the NPR1-TGA1 system of Arabidopsis thaliana by nitric oxideChristian Lindermayr
Institute of Biochemical Plant Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
Plant Cell 22:2894-907. 2010..Here, we report the effect of the physiological nitric oxide donor S-nitrosoglutathione on the NPR1/TGA1 regulation system in Arabidopsis thaliana... - The chemical biology of nitric oxide: implications in cellular signalingDouglas D Thomas
Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
Free Radic Biol Med 45:18-31. 2008b>Nitric oxide (NO) has earned the reputation of being a signaling mediator with many diverse and often opposing biological activities... - Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effectsJ Jose Corbalan
School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences, Panoz Institute, Trinity College Dublin, Dublin, Ireland
Int J Nanomedicine 6:2821-35. 2011..The purpose of this study was to investigate the mechanism of noxious effects of amorphous silica nanoparticles on human endothelial cells... - Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter?Daniel J Green
Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Tom Reilly Building, Byrom Street, Liverpool L3 3AF, UK
Hypertension 57:363-9. 2011..been assumed that this association is related to the proposal that FMD provides an index of endothelium-derived nitric oxide (NO) function... - Complex inhibitory effects of nitric oxide on autophagySovan Sarkar
Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0XY, UK
Mol Cell 43:19-32. 2011..Several autophagy regulators have been identified in recent years. Here we show that nitric oxide (NO), a potent cellular messenger, inhibits autophagosome synthesis via a number of mechanisms... - Aged garlic extract enhances production of nitric oxideNaoaki Morihara
Healthcare Research Institute, Wakunaga Pharmaceutical Co Ltd, 1624 Shimokotachi, Kodacho Takatagun, 739 1195, Hiroshima, Japan
Life Sci 71:509-17. 2002b>Nitric oxide (NO) controls several physiological functions of the cardiovascular system... - Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formationN A Riobo
Laboratory of Oxygen Metabolism, University Hospital, University of Buenos Aires, Cordoba 2351, 1120, Buenos Aires, Argentina
Biochem J 359:139-45. 2001..Inhibition of Complex I activity by peroxynitrite may have critical implications for energy supply in tissues such as the brain, whose mitochondrial function depends largely on the channelling of reducing equivalents through Complex I... - Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2AAnthony R Smith
Linus Pauling Institute and Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
Aging Cell 5:391-400. 2006..that post-translational signaling pathways become disrupted with age and adversely affect endothelial nitric oxide synthase (eNOS) activity and endothelial-derived nitric oxide (NO) production... - Cellular signaling and NO productionThomas Michel
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Pflugers Arch 459:807-16. 2010..The best characterized endothelium-derived relaxing factor is nitric oxide (NO), which is synthesized by the endothelial isoform of nitric oxide synthase (eNOS)... - Mitochondrial generation of free radicals and hypoxic signalingRobert O Poyton
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Trends Endocrinol Metab 20:332-40. 2009..Recently, it has become clear that under hypoxic conditions, the mitochondrial respiratory chain also produces nitric oxide (NO), which can generate other reactive nitrogen species (RNS)... - Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancerStefan Ambs
Laboratory of Human Carcinogenesis, Center for Cancer Research CCR, National Cancer Institute NCI Bethesda, MD USA
Cell Cycle 10:619-24. 2011Inducible nitric oxide synthase (NOS2) is an inflammation responsive enzyme (EC 188.8.131.52) that is induced during acute and chronic inflammation and tissue injury as part of the host defense and wound healing process...
Research Grants
- Iron-mediated vascular disease in sickle cell disease.John C Wood; Fiscal Year: 2010..which releases red cell components in the circulation, is a leading cause of vasculopathy and acts by impairing nitric oxide bioavailability...
- Role of Chromogranin A in Metabolic SyndromeSushil K Mahata; Fiscal Year: 2013..CST transiently stimulates gluconeogenesis by attenuating endothelial nitric oxide synthase (eNOS) and 5'-adenosine monophosphate-activated protein kinase (AMPK), and enhances glucose ..
- Angiotensin Adrenergic Interactions in the KidneyRoland C Blantz; Fiscal Year: 2013..A/I kidney including NADPH oxidase, heme-oxygenase-1 (HO-1),, and ERK 1/2 phosphorylation and functional nitric oxide activity was decreased...
- Peroxynitrite Decomposition Catalyst and Nitric Oxide Donor for EndotoxemiaGARRY JOHN SOUTHAN; Fiscal Year: 2012DESCRIPTION (provided by applicant): Alterations in the biosynthesis of the free radicals nitric oxide (NO) and superoxide anion are generally accepted to contribute to widespread tissue injury in sepsis via their induction of ..
- Ang II and Aldosterone Effects on Insulin Resistance in Cardiovascular TissueJAMES RUSSELL SOWERS; Fiscal Year: 2013..employ direct visualization of skeletal muscle arterioles using video microscopy to evaluate insulin induced nitric oxide dependent vasodilation...
- Roles of Nitric Oxide and Superoxide in CystitisANTHONY JOHN KANAI; Fiscal Year: 2013..During the first grant period, we used nitric oxide (NO*), nitrite (NO2-) and peroxynitrite (ONO2-) microsensors along with Ca2+ imaging to determine that ..
- Ang II and Overnutrition and Insulin resistance in Cardiovascular TissueJAMES RUSSELL SOWERS; Fiscal Year: 2013..ANG II in CV tissue leading to diminished INS metabolic signaling and biological consequences, such as impaired nitric oxide (NO)-mediated vascular relaxation...
- The influence of air pollution mixtures on biomarkers of airway oxidative stressRoby Greenwald; Fiscal Year: 2013..Before and after athletic practice sessions, they will conduct pulmonary function tests, measure exhaled nitric oxide, and collect samples of exhaled breath condensate for analysis of markers of oxidative stress and lipid ..
- Preclinical Development of JS-K, a Novel NO-Generating Prodrug for CancerPaul J Shami; Fiscal Year: 2012..b>Nitric oxide (NO) is well known to kill cancer cells without harming normal bone marrow cells, but until now has not been ..
- Alternative Macrophage Activation Limits ImmunopathologyDEBROSKI R HERBERT; Fiscal Year: 2011..g., TNF, IL-12, IL-23) and nitric oxide (NO) that, together, drive potent anti-microbial functions...
- Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground MiJefferey L Burgess; Fiscal Year: 2013..Urinary 8- hydroxy-2'-deoxyguanosine (8-OHdG) will be assayed to assess oxidative DNA damage. Exhaled nitric oxide (NO), a marker of airway inflammation, and exhaled carbon monoxide (CO), a marker of CO exposure will both be ..
- Neural mechanisms by which chronic stress regulates inflammation in asthmaMelissa A Rosenkranz; Fiscal Year: 2013..examined in relation to measures of lung function (FEV1), inflammation (sputum and blood eosinophils, exhaled nitric oxide), sensitivity of immune cells to inhibition by glucocorticoids, stress responsivity (salivary cortisol and ..
- Novel Peptide MPO Inhibitors for Treating AtherosclerosisKirkwood A Pritchard; Fiscal Year: 2012..MPO catalytically consumes nitric oxide ([unreadable]NO) and converts it to nitrite (NO2-)...
- Targeting iNOS to inhibit myeloid-derived suppressor cells (MDSC) in melanomaANDREW GREGORY SIKORA; Fiscal Year: 2013..and potently inhibit anti-tumor T cell responses through a variety of mechanisms including production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS)...
- REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORNGirija G Konduri; Fiscal Year: 2013..Activation of NADPH oxidase and uncoupled activity of endothelial nitric oxide synthase (eNOS) are sources of superoxide (O2[unreadable]-) in the pulmonary arteries in PPHN...
- Parathyroid Hormone & Vitamin D Effects on Salt Sensitivity and Vascular FunctionANNA LIZA BELEN VALINA TOTH; Fiscal Year: 2010..activation of fibroblasts, insulin resistance, dyslipidemia, fat deposition and down regulation of endothelial nitric oxide - all of which plausibly contribute to elevated blood pressure (BP)and vascular and pressure- sensitive target ..
- Conference on Autonomic Regulation of Cardiovascular Function in Health and DiseaMartin Frank; Fiscal Year: 2012..g. the hypothalamus and medulla). Symposia and poster presentations will focus on reactive oxidant stress, nitric oxide, angiotensin II, angiotensn (1-7), glutamate, GABA and the transcriptional and translational regulation of the ..
- Expression of sFlt1 and its function in the glomerular endotheliumChristie P Thomas; Fiscal Year: 2013..We hypothesize that sFlt1 inhibits glomerular endothelial nitric oxide synthase (eNOS) and NO release which in turn increases ET-1 expression and release from GEC...
- Analysis of gene regulation of Vibrio cholerae during infectionJun Zhu; Fiscal Year: 2013..Next we will examine how AphB is modified by reactive nitrogen species (RNS), such as nitric oxide (NO), and oxidative stress from reactive oxygen species (ROS) generated in vivo and how these modifications ..
- Nitric Oxide in Hemodialysis AV Fistula MaturationRichard A Cohen; Fiscal Year: 2010..Oxidative stress and reduced nitric oxide (NO) bioavailability are important contributors to the accelerated vascular disease that accompanies ESRD, and ..
- Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for CerebrLEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012..In the murine model of CM by Plasmodium berghei ANKA (PbA), CM has been associated to low nitric oxide (NO) bioavailability, and treatment with exogenous NO prevented CM development...
- Arginine Availability and Metabolism in the Immune Evasion of H. pyloriKeith T Wilson; Fiscal Year: 2013..pylori. L-Arg is the common substrate for two divergent enzymatic pathways: inducible nitric oxide (NO) synthase (iNOS), that generates high output NO;and arginase, consisting of two forms, arginase I (Arg1) ..
- UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosisShiyong Wu; Fiscal Year: 2012..The objective of this application is to elucidate the mechanisms that regulate UV-induced apoptosis via nitric oxide synthase (NOS) mediated signaling pathways and to determine the roles of nitric oxide (NO)/peroxynitrite (ONOO) ..
- Mechanism Underlying Nitrite Sensitivity of Mucoid Pseudomonas in COPDDaniel J Hassett; Fiscal Year: 2013..Provision of mucA in trans restored A-NO2- resistance and subsequent experiments established that nitric oxide (NO) plays a role in cell death...
- Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and StatinsTHOMAS JAY EBERT; Fiscal Year: 2013..In addition, the involvement of reactive oxygen species (ROS) and the nitric oxide pathway in the harmful effects of hyperglycemia and the beneficial effects of statins will be explored...
- Advanced Nitric Oxide Release Bactericidal Urinary CathetersMark E Meyerhoff; Fiscal Year: 2013..polymeric formulation to effectively reduce catheter-associated urinary tract infections (CAUTI) via nitric oxide (NO) release...
- Novel Means to Establish Free Radical Balance in the Neonatal Premature LungPrakash Jagtap; Fiscal Year: 2011..of RDS and BPD is consistent with a mechanism of injury produced by an excess of O2- and a deficiency of nitric oxide (NO) within the lung parenchyma...
- Interactions of the RAAS and a Western Diet on Insulin Metabolic ActionsJAMES RUSSELL SOWERS; Fiscal Year: 2013..in CV tissue leading to diminished INS metabolic signaling and biological consequences, such as impaired nitric oxide (NO)-mediated vascular relaxation...
- DNA Repair Deficiency Associated with Obesity and the Metabolic SyndromeR Stephen Lloyd; Fiscal Year: 2013..of NEIL1 in the modulation of survival, mutagenesis, and mitochondrial function in response to oxidative or nitric oxide stress conditions...
- Cholesterol and Lymphatic Transport of Molecules and CellsMelody A Swartz; Fiscal Year: 2012..vasculature, it is known that hypercholesterolemia induces endothelial dysfunction by negatively affecting nitric oxide synthases (NOS) and production of nitric oxide (NO), and NOS activity in blood vessels can be restored by ..
- FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINSJohn S Olson; Fiscal Year: 2010..determine the mechanism of how these proteins, microbial single domain globins, and flavohemoglobins oxidize nitric oxide to nitrate. Many of the specific aims associated with these goals have been achieved...
- Citrulline to Prevent or Mitigate Acute Lung Injury in Severe SepsisTodd W Rice; Fiscal Year: 2013..Inflammation results in plasma citrulline deficiency which leads to arginine deficiency and uncoupling of nitric oxide synthase (NOS)...
- Parvalbumin-Containing Neurons in SchizophreniaTsung Ung W Woo; Fiscal Year: 2013..that promote oxidative stress, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) and neuronal nitric oxide synthase (nNOS), and the catalytic and modulatory subunits of the antioxidant enzyme glutamate cysteine ligase ..
- A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial HypertensionSteven Kawut; Fiscal Year: 2009..Simvastatin decreases cholesterol, stabilizes the endothelial cell layer, increases the bioavailability of nitric oxide, reduces oxidative stress, and decreases inflammation...
- Tadalafil for Pulmonary Hypertension Associated with Chronic Lung DiseaseSHARON IRENE SMITH ROUNDS; Fiscal Year: 2013..to maintain pulmonary vascular tone by degrading cGMP, which is a key signaling intermediary involved in nitric oxide (NO)-dependent signaling...
- Antenatal Betamethasone in Late Preterm Gestation LambsSATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010..We will study the changes in important mediators of pulmonary transition at birth such as nitric oxide, beta adrenergic agents, natriuretic peptides and prostaglandins secondary to antenatal glucocorticoid use...
- Effects of GSH +/- Arginine on Markers of Inflammation Among Adults with CVD RiskChristopher D Gardner; Fiscal Year: 2010..fasting insulin, serum isoprostanes (a measure of oxidative stress) and s-nitrosyl glutathione (a stable, nitric oxide containing compound)...
- Scavenging of Reactive Oxygen and Nitrogen Species by CobalaminsNICOLA ELIZABETH BRASCH; Fiscal Year: 2011..oxidative and nitrosative stress" - elevated levels of Reactive Oxygen and Nitrogen Species (ROS/RNS), such as nitric oxide, superoxide, the hydroxyl radical, hydrogen peroxide and peroxynitrite...
- Respiration in SepsisClaude A Piantadosi; Fiscal Year: 2013..New preliminary data links AMPK activation to nitric oxide synthase-2 (NOS2) induction in sepsis, does not require high AMP/ATP, and loss of AMPK activation in nitric ..
- Role of Heme Oxygenase-1 in SepsisMark A Perrella; Fiscal Year: 2010..has numerous biological functions, including anti- inflammatory properties, and shares many similarities with nitric oxide (NO), such as its ability to modulate vascular tone by increasing cGMP levels...
- Tumor Cell Arrest and Adhesion in the MicrocirculationBingmei M Fu; Fiscal Year: 2013..mechanical factors, microvascular permeability (vascular integrity), cell adhesion molecules, nitric oxide and cytokines, and tumor metastasis in intact microvessels...
- Metabolic impact of fructose restriction in obese childrenJean Marc Schwarz; Fiscal Year: 2013..by stable isotope measurement), lipid partitioning within tissues (by magnetic resonance spectroscopy), and nitric oxide metabolites (by HLPC and ELISA) in children with metabolic syndrome, stratified by race and gender;and then ..
- Iron, NO, and Lipid Peroxide in Photodynamic TherapyALBERT GIROTTI; Fiscal Year: 2013..Studies supported by the existing grant have focused largely on the effects of nitric oxide (NO) in this regard...
- Molecular Mechanism of Acrolein-Induced Vascular Toxicity: Role of PPAR gamma andZivar Yousefipour; Fiscal Year: 2013..This process involves nitric oxide (NO) and oxygen free radicals...
- Role of endothelin receptors in glaucomatous optic neuropathyRaghu R Krishnamoorthy; Fiscal Year: 2013..coupled receptors, namely, the ETA and ETB receptors, which are B predominantly linked to the calcium and nitric oxide signaling pathways respectively...
- Mechanisms of Vasovagal SyncopeJulian M Stewart; Fiscal Year: 2013..Preliminary data support the hypothesis that production of nitric oxide (NO) is enhanced in these patients resulting in reduced sympathetic noradrenergic neurotransmission at pre-..
- Novel Therapeutic Targets in Necrotizing EnterocolitisPeter J Giannone; Fiscal Year: 2012..Exciting new mechanisms regarding the pathogenesis of NEC have recently become known and nitric oxide (NO) dysregulation appears to play a major role in the development of NEC...
- Nitric Oxide Signaling with Heme ProteinsWilliam R Montfort; Fiscal Year: 2012..competitive renewal of grant HL62969, focusing on the biophysics of nitrosyl heme chemistry and its role in nitric oxide (NO) signaling...
- Nitric Oxide and gastric motility in female diabeticsPandu R Gangula; Fiscal Year: 2010..Recent studies have implicated a role for dysregulation of neuronal nitric oxide synthase (nNOS) in myenteric neurons and we surmised that gender differences in nitrergic control of gastric ..
- ROLE OF SAMe IN LIVER FUNCTION AND INJURYSHELLY CHI LOO LU; Fiscal Year: 2012..Our new data also show cross-talks between AMPK and nitric oxide synthase in modulating the proliferative effect of HGF. How SAMe regulates these pathways will be elucidated. 2...
- Mechanism of eNOS Uncoupling in the Renal MicrovasculatureYVES CLAUDE GORIN; Fiscal Year: 2013..A major defense of endothelial cells against vascular injury is endothelial nitric oxide synthase (eNOS), which generates nitric oxide (NO) in the presence of optimal concentrations of the substrate L-..
- Nitric Oxide in Pulmonary HypertensionSerpil C Erzurum; Fiscal Year: 2013..The PAH cells have impaired production of the vasodilator nitric oxide (NO) due to post- translational mechanisms that include phosphorylation/inhibition of endothelial NO synthase (..
- Electron Transfer in Iron and Copper ProteinsJay R Winkler; Fiscal Year: 2013..Important members of this class of enzymes are the heme-thiolate mono- oxygenases such as cytochrome P450 and nitric oxide synthases (NOS)...
- Regulation of the Endothelial Citrulline-Nitric Oxide CycleDuane C Eichler; Fiscal Year: 2010..a unique perspective of endothelial health, showing that argininosuccinate synthase (AS) of the citrulline-nitric oxide cycle must be functional to sustain nitric oxide (NO) production and to maintain cell viability...
- Endothelium-Myocardium Interaction in Netrin-1 Induced CardioprotectionHUA LINDA CAI; Fiscal Year: 2013..cardioprotection in vivo and whether the protection is mediated by a DCC-ERK1/2-deepdent activation of eNOS /nitric oxide (NO") in cardiac microvascular endothelial cells that should be immediately activated upon netrin-1 perfusion, ..
- Control of Drug Delivery to the CNS: Modulating P-glycoprotein ActivityWilliam A Banks; Fiscal Year: 2013..blood-brain barrier, Brain, CNS, p-glycoprotein, innate immune system, cytokines, tumor necrosis factor-alpha, nitric oxide BRIEF STATEMENT OF RESEARCH OBJECTIVES (Do not use continuation sheets) A major problem in developing effective ..
- A new ultra-low field in-vivo EPR technology for biomedical applicationsInseob Hahn; Fiscal Year: 2012..provided by applicant): The most successful uses of in vivo EPR have been non-invasive measurement of oxygen, nitric oxide, bioradicals, pH and redox state, with applications in oncology, cardiology, neuroscience and toxicology...
- A new ultra-low field in-vivo EPR technology for biomedical applicationsInseob Hahn; Fiscal Year: 2011..provided by applicant): The most successful uses of in vivo EPR have been non-invasive measurement of oxygen, nitric oxide, bioradicals, pH and redox state, with applications in oncology, cardiology, neuroscience and toxicology...
- Transplantation of Reduced-Size Fatty LiversZhi Zhong; Fiscal Year: 2010..of antioxidants (Ad-superoxide dismutase, N-acetylcysteine and polyphenols) and antinitrative therapies (nitric oxide synthase inhibitors) on survival and injury of fatty partial grafts will be evaluated...
- Dietary Scavenging of Reactive Species in Lung Injury: Role of MacrophagesTHEA NOREEN GOLDEN; Fiscal Year: 2013DESCRIPTION (provided by applicant): Nitric oxide plays a central role in respiratory physiology including regulation of airway tone, vasodilation, inflammation and lung morphogenesis...
- Rheologic and Vascular Modulators in Sickle Vaso-occlusionDhananjay K Kaul; Fiscal Year: 2012..hypothesize that HIF-1[unreadable] expression will be dependent not only on tissue oxygen tension, but also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
- Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic StrokeYanfang Chen; Fiscal Year: 2013..Reactive oxygen species (ROS) have been recognized as a major factor contributing to ischemic damage. Nitric oxide (NO) from endothelium nitric oxide synthase (eNOS) is important in maintaining normal cerebral blood flow...
- Nitric Oxide Releasing Topical Gel for Burn Wound HealingANJAL SHARMA; Fiscal Year: 2007unreadable] DESCRIPTION (provided by applicant): Nitric oxide (NO) gas has been shown to play a significant role in the promotion and regulation of diverse wound healing processes, including burn wounds...
- Nitric Oxide in Pulmonary HypertensionSerpil Erzurum; Fiscal Year: 2009..The PAH cells have impaired production of the vasodilator nitric oxide (NO) due to post- translational mechanisms that include phosphorylation/inhibition of endothelial NO synthase (..
- NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESISMARION CHAN; Fiscal Year: 2004..Current studies suggest that nitric oxide (NO) and peroxynitrite are crucial for elimination of the Leishmania parasites...
- Arginase and Regulation of Nitric Oxide Synthase in ALSRajiv Ratan; Fiscal Year: 2004..As nitric oxide (NO) has been shown to mediate neuronal loss in other neurodegenerative conditions, several groups have ..
- Renal Control of Blood Pressure in Early DiabetesMichael Brands; Fiscal Year: 2007..in diabetes causes significant renal vasoconstriction and hypertension if it occurs under conditions of chronic nitric oxide (NO) synthesis inhibition...
- NITRIC OXIDE AND GASTROINTESTINAL OXIDATIVE INJURYWalee Chamulitrat; Fiscal Year: 1999..Constitutive nitric oxide regulates GI motility, leukocyte adherance and mucosal permeability...
- SUBSTANCE P, NO & MICROGLIA IN CNS INFLAMMATIONBarnett Nathan; Fiscal Year: 2003..next 5 years I plan to study in vitro and in vivo the interactions of microglia, macrophages, substance P and nitric oxide as well as the effect of these substances on mitochondrial function...
- Targeting Inflammation to Improve Endothelial Function in Type 2 Diabetes: A SubsMark A Creager; Fiscal Year: 2010..including type 2 diabetes mellitus, are associated with decreased bioavailability of endothelium-derived nitric oxide (NO) and impaired endothelium-dependent vasodilation, and impaired endothelial function predicts cardiovascular ..


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Comments Thread For: Roach: Mayweather, Bradley, Berto-Ortiz Next For Khan
Trainer Freddie Roach is outlining some every big opponents for Amir Khan. He wants the British star to face a major opponent in the next couple of months. On Saturday night at the MEN Arena in Manchester, Khan (25-1, 17KOs) retained his WBA junior welterweight with a six round technical decision over Paul McCloskey (22-1, 12KOs). Their bout was stopped early in the sixth round after a clash of heads opened up a cut above the left eye of McCloskey. All three judges scored it 60-54.
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3/3/2015 ARKANSAS TOURISM NOTICE: Arkansas's Seven Show Caves Are Open to the Public
The derby is limited to 50 contestants, ages 5 –15. Prizes will be awarded in three age divisions for the biggest, smallest, and the most fish caught. Registration opens May 1, 2014. Small children will be allowed to have an adult cast for them and or bait their hooks, but the child must land the fish. Be sure to bring your own bait and equipment. Contact the park for further details. Pre-registration is required due to space and fish resource limitations.
Logoly State Park P.O. Box 245 McNeil, AR 71752 Ph: (870) 695-3561 firstname.lastname@example.com


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Someone Old, Someone New
Tuesday, 17 February 2015
Laser Eraser meets Judge Anderson by Chris Wildgoose
I've been a fan of Chris' work since i bought the stunning "Porcelain" graphic novel, a terrific tale and i'm SO looking forward its sequel. The new ongoing "Butterfly Gate" is very much recommended too:
As well as being a terrific artist and excellent draughtsman, i'm also always taken at how brilliant Chris is at drawing women, not having to go the cliche, pouting, baps out route to make a character distinctive:
I'd already had the fella pegged for contributing to this here project and thought he'd be a natural for a two female matching, something i've thought is needed after all the macho-ness as what we've seen so far.
But what females?
Well, i've gone with Anderson for the modern as she's still pretty regularly in print
And, looking for a strong, independant female to match her, i've gone for Mysta Mistralis, the Laser Eraser who, along with partner Axel Pressbutton, have been crimingly over-looked when talking reprints, graphic novels and merchandise. Lets have some now!
As usual with these projects, the thrill of it is seeing the completed piece and that was true here as Chris never sent me any premlims or thumbnails.
Stunned and amazed by what i was presented with a couple of days ago - he's nailed both characters perfectly (even down to the padding of Mysta's clothing), in a brilliant moment and, as my wife said when i showed her it, "that's how you draw women".
Friday, 16 January 2015
Balls rolling
So to speak.
Yep, a bunch of the proverbials are rolling as i type and hopefully there'll be new treats to share with you before long, both here and over on my "Batman 186" project (link to it is on the sidebar to the right) and i'm really looking forward to that.
As a taster, a wee glimpse from a prelim of one of the new pieces and, as i'm sure you can tell from the ear, its for Batman 186
Yep, a bunch of the proverbials are rolling as i type and hopefully there'll be new treats to share with you before long, both here and over on my "Batman 186" project (link to it is on the sidebar to the right) and i'm really looking forward to that.
As a taster, a wee glimpse from a prelim of one of the new pieces and, as i'm sure you can tell from the ear, its for Batman 186
Saturday, 20 April 2013
Shakara vs Biogs by Conor Boyle
Right from the start of this project, i wanted Shakara to be one of the "new" characters. Okay, that was quite a while back now and there's been no tale of the fella for a long while, but i still wanted him in there. And, being an adversary of all manner of alien races, there was only one type that i wanted for the "old" - the Biogs from way back in Prog 1 of 2000AD and the relaunch of Dan Dare.
I've waffled on long-time over on my "AIEEEE!" Blog about my love for Massimo's incredible creations, so i won't repeat myself here.
Top choice for the project was Shakara's co-creator himself, Henry Flint. But Henry doesn't take on commissions, so i thought the scene would remain an idea and no more.
But then i met Conor Boyle at a Demoncon in Maidstone (scroll down the page here for more of what Conor produced for me that day) and i was blown away by his talent and his incredible fine detail work. And that was just for his sketches.
When i saw what he did for comics and commissions, i knew i'd found a perfect artist for the job.
Happily, Conor was up for the gig, once he'd got some other pieces done and it wasn't long before we were discussing first basic composistions, of which there were four:
and then slight tweaks here and there until he arrived at what you see here today. I'm SO pleased with this its untrue - he's nailed Shakara perfectly and he's done something that i didn't ask him to do, which is something i loved that the Biogs did in the Dan Dare strip sometimes -frown over those massive eyes they have, giving them a real sinister appearance. Top Bloke that Conor - friendly, polite and very, very talented.
Ta ever so Conor!
Monday, 13 August 2012
Old One Eye vs Gorehead by James McKay
Was SO thrilled to hear that Flesh was coming back. Not only coming back, but it'd be a direct sequel to my 2nd favourite strip when 2000AD first started.
It'll have Trans Time!
It'll have cowboys!
It'll have outlandish dinosaur gore!
And, hopefully, great looking dinosaurs too.
Happily, James really delivered on that front and, as soon as i read the first episode, i got in touch with the fella to see if he'd take part in this here project.
Straight away i knew what i wanted:
The now totally inaccurate, standing bolt upright, portly, big-headed Old One Eye:
Going up against the totally accurate, brilliantly realised Gorehead:
James was up for it alright, but work pressures has meant its taken until now to see just what would happen when the two meet.
Fantastic isn't it?
But, who's going to win?
Ta ever so James for doing this!
Flesh © 2012 Rebellion A/S. All rights reserved. www.2000ADonline.com
Tuesday, 24 July 2012
A spin-off project
An idea i had long before this project was to do with this Bat-cover.
Its my Number 1 image from my childhood Bat-reading, an image that's stayed with me all these years and, even now, looking at it i get a deep down, emotional reaction to it.
So, i thought it'd be nice to ask artists to have a go at their own version of it.
As long as the three characters were there and were doing what they're doing, how they went about it and what it'd look like is totally up to them.
Very pleased to say that i've my first two now.
If you care to pop over to my Bat-Blog, you'll see them in all their glory:
Monday, 23 April 2012
Black Max by Lawrence Cambell
Also at Demoncon was Lawrence Cambell - charming, brilliant artist doing head sketches for free.
So out comes my Max reference pic.
I left it with Lawrence and came back later.
I'd mentioned that Max is based on Boris Karloff and Lawrence had Googled his image on his iPhone and was using that classic, iconic shot from "The Mummy", which i think you can really see here.
Giant Bat by Conor Boyle
Was at Maidtone's Demoncon comic convention yesterday and i met the VERY talented and hopefully to be a star soon, Conor Boyle.
Great guy, great artist and didn't mind me at all thrusting a reference pic of Black Max's beastie to have a go at.
He's nailed that long cat/bear face hasn't he?
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Do waiters really want me to order coffee/dessert?
Feb 04, 2007 by jfood in Not About Food
Movie Food: Marie Antoinette
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How to keep cheese in refrig from being moldy?
Feb 14, 2007 by luuuu in Cheese
[MSP] Places in Twin Cities for espresso?
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Guava anything
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Differences between cornmeals
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Chinese steamed dumplings
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Fresh herbs
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Joe's Garage MSP, and some philosophy
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Best restaurant for birthday dinner for two
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What should stock contain?
Jan 21, 2007 by Yaqo Homo in Home Cooking
Ever Make a Seaweed Salad?
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Wild rice shelf life?
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Little Szechuan - closed for remodeling
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[MSP] Shopping for Chowish gifts in the Twin Cities
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Where to take a picky out-of-towner (Minneapolis)
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Grass-fed beef [moved from General Topics]
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Godiva Bashers- I need advice
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Do you eat hydrogenated fat?
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Looking for a recipe for leek or other veggie dumplings
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Examples of Responses to Questions in the 2011 Examinations In keeping with our drive here at CXC to enhance the support provided to candidates who are preparing to write our examinations, we are displaying on our website exemplars of candidates' responses to examination questions. These are authentic, unedited responses. They are presented in the candidates' own handwriting, accompanied by comments from the Examination Committee that indicate the Committee's judgement of the quality of the responses and the justification for arriving at that judgement. This is a pilot effort, covering only selected subjects. We at CXC welcome your feedback on how useful you find this information to be and, in particular, how we can improve on the provision of such information. Your comments will contribute to the future expansion and refinement of this material.
Question 1
Question 2
Question 4
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Human and Social Biology is concerned with the study of the structure and functioning of the human body. It also involves the application of biological principles, knowledge and skills, and technological advances, to the maintenance of health and to solve the problems of living together. The subject incorporates the view that human beings have a responsibility to their environment and, as such, have an obligation to conserve, protect, maintain and improve its quality.
The CSEC Human and Social Biology syllabus is designed to allow students to work individually and cooperatively, utilizing theoretical concepts of the course in interactive and practical activities. Students are expected to apply investigative and problem-solving skills, be effective in communicating scientific knowledge and demonstrate an appreciation for all living organisms in their environment.
The syllabus is organised under five main sections:
i. Living organisms and the environment.
ii. Life processes.
iii. Heredity and variation.
iv. Disease and its impact on humans.
v. The impact of health practices on the environment.


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Description:Behold Psychic puppy! Can't wait for the results? No need to fear this little pup with be predicting the outcome of upcoming world cup games. In support of Dogs Trust. (0:55)
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Tags: 2014 World Cup , england vs italy , fifa , Football


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adapting a script to my template (another IE VS NS thing)
Hey, this will prob not be an easy question to follow, but i'll give it my best...
I found this script that i am trying to adapt to my website, the exact function is irrelevant because even if not working at all, the problem is with the way it fits into my sites template...
my website (*removed*) has a template that i would like this new script to follow (*removed*)... now, i've done a fairly decent job at doing this, at least for the most part... (*removed*) i still need to play with the CSS so that it dosn't jump arround like it does now, however, the biggest problem i have, is that its not precisely what i want... if you go to the 'test.php' page under IE, the script goes outside of my table... however, it works exactly like i want it to in Netscape...
The most amazing part is that i keep IE in mind, not NS... Regardless how that came to be, i need help to figure out why IE won't do it....
I'll apreciate any sugestions, even if its something that may seem obvious...
RayLast edited by Psychoman; 06-09-2004 at 03:50 AM.
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What do you mean by
I can open the page and nothing seems to be placed outside the table.if you go to the 'test.php' page under IE, the script goes outside of my table...
I don't know if it's relevant (since i haven't got a clue about the problem) but
an important difference between IE and NS is that NS will not display content of atable, untill the complete table is loaded into the browser. So in NS, you shouldn't get the jumping columnborders.
Also, your attributevalues for height and width don't always have a % and it's rather strange to have part of the cells defined relative.
You probably already know, but using tables for layoutpurposes isn't realy the way to go.
Posting guidelines I use to see if I will spend time to answer your question : http://www.catb.org/~esr/faqs/smart-questions.html
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Well, you may have been seeing the page as i was trying to fix it, its halfway there, i mean, at least now it is presentable, however, i wish i could have it blockquoted.
I understand what you said about NS being the one that would give me the problem, but its actually NS that is displaying right in both versions... It is IE thats giving me problems...
*removed* is the one that is as of now the best i can find on both IE and NS
*removed* is the one with the problem in IE, but exactly how i want it in NS (again, pay attention to the right of the FAQ)
as for the positioning using tables, yes i understand that tables is not the best way to position, however it is the method i used because i will be adding other scripts that will enhance the site that i only know how to do with tables as of now, however, once the site is 100% up, i will spend time changing it to CSS positioning.
hopefully this clears things up a bit... for now, thanks for taking time to at least try to understand my question
Last edited by Psychoman; 06-09-2004 at 03:50 AM.


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Countdown to Opening Day: Toronto Blue Jays
"Touch 'em all, Joe! You'll never hit a bigger home run in your life!" That legendary call in the 1993 World Series is the last time the Toronto Blue Jays were in the playoffs. With the Kansas City Royals
Marcus Stroman Out For 2015 Season With Torn ACL
The Toronto Blue Jays announced that pitcher Marcus Stroman is out for the season.
Edwin Encarnacion Out 4-5 Days
Toronto's Edwin Encarnacion likely will be sidelined for four to five days because of back inflammation.
Jays' Michael Saunders Out Until Break
Toronto Blue Jays left fielder Michael Saunders stepped on a sprinkler while shagging fly balls Wednesday, tearing cartilage in his left knee and sidelining him until the All-Star break.
Report: Dan Duquette Isn't Headed To Blue Jays
The Orioles and Blue Jays have had negotiations for days about GM Dan Duquette, but know it appears that the talks have fallen apart.
Takashi Toritani Has Offers From Blue Jays, Padres
Japanese infielder Takashi Toritani is an unrestricted free agent and reportedly has offers from both the Toronto Blue Jays and San Diego Padres.
Report: Blue Jays Eyeing Dan Duquette As Next President
The Toronto Blue Jays as been eyeing Baltimore Orioles GM Dan Duquette as the team's next president.
Blue Jays To Acquire Josh Donaldson From Athletics For Brett Lawrie
The Toronto Blue Jays have made quite the splash by acquiring Josh Donaldson from the Oakland Athletics in exchange for a package headline by Brett Lawrie.
Don Wakamatsu Has The Resume To Take Over Rays
The Tampa Bay Rays have whittled the search for their next manager to three and it's not hard to see the appeal of former Seattle manager Don Wakamatsu.
Kevin Cash Should Be The Rays Next Manager
Despite being just 36 years old Kevin Cash has is more than qualified to be the next manager of the Tampa Bay Rays.


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From "Hypnosis For Happiness," out July 2, 2013.
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"You can't plan every piece," sings Grant Olney on the new single "Not From Body," but the tough puzzle of learning to love and getting fitful glimpses of peace all falls into place.
If you have questions or need to contact KDHX, visit our answers portal at answers.kdhx.org.


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Roselle is located in Illinois. Roselle, Illinois has a population of 24,287. Roselle is less family-centric than the surrounding county with 40.12% of the households containing married families with children. The county average for households married with children is 40.12%.
The median household income in Roselle, Illinois is $77,073. The median household income for the surrounding county is $76,878 compared to the national median of $53,046. The median age of people living in Roselle is 37.4 years.
The average high temperature in July is 86 degrees, with an average low temperature in January of 12 degrees. The average rainfall is approximately 32 inches per year, with 23.5 inches of snow per year.
Real Living Gobber Realty 1860 S. Mannheim Rd. Westchester, IL 708-531-0800 Real Estate Agents & Staff


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Apr 24
Sounds Like: Ben Gibbard, Father John Misty, Bon Iver, The Classic Crime, Lovedrug
Bio: Probably the most interesting piece of my past is that I was raised in a cult. From there I learned a lot about myself and about others and now try to take a stand against abuse in all forms. A lot of the songs written in the "I Fall in Love Everyday..." EP were written with that goal in mind.
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Here is my loot I got today. I am getting my pantry restocked with some of our fave items from Trader Joe's as well as getting ready for school. I purchased sourdough bread, BBQ sauce, Chocolate syrup, snacks, granola bars, cereal bars, pizza crust (so cheap and yummy. We freeze it even.), mini mint ice cream sandwiches (to die for. You will thank me later.) and a few little extras since I felt like splurging a little. What can I say I was excited. I've lived in Tennessee for 6 years and I have waited for a Trader Joe's to open since I moved here. .
I wanted to share Trader Joe's coupon policy as well as a repost of the weekly deals.
Products and Prices may vary store to store.
Baby Spinach 6oz $2.49
Romaine Hearts 3pk $2.69
Herb Salad Mix 5oz bag $2.49
Romaine Mix 9oz $2.69
White Button Mushrooms 8oz $1.99
Broccoli Slaw 12oz $1.
All Natural 90/10 lean Ground Beef 1lb $4.99
All Natural 96/4 lean Ground Beef 1lb $4.99
Kosher Ground White Turkey 16oz $4.69lb
Organic Free Range Chicken Breast boneless skinless $6.99lb ( avg pkg price $8.30)
Organic Free range Chicken Legs $1.99lb (avg pkg price $3.30)
Applegate Farms Uncured Hot Dogs $4.99
$1.00 Applegate Farms Hot Dog Coupon
Total Price= $3.99
Trader Joe's Organic Basmati Rice 32oz bag $3.99
Trader Joe's Organice Red Quinoa 16oz $3.99
Trader Joe's Organic Quinoa 16oz $3.99
Trader Joe's Gluten Free Rice Bread $3.99
Trader Joe's Gluten Free French Rolls $3.49
Trader Joe's Gluten Free Rye $3.79
Trader Joe's Sprouted Wheat Berry $3.49


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Replacement Model:
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Average Customer Reviews
Energy Star Rated - Yes
Effortless™ Humidity Control Allows you to control the exact percentage of humidity in your room.
Energy and Cost Savings The unit operates at a low temperature – using less energy and saving you money.
Improves Home Environment Protects your home from mold and mildew caused by excess moisture – and helps eliminate bacteria in the air that can make breathing difficult.
Effortless™ Automatic Shut Off Unit shuts off automatically when the water tank is almost full.
Effortless™ Full Tank Alert System Alerts you when your water tank nears capacity and it is time to empty the water bucket.
Front Loading Bucket with Carrying Handle and Splash Guard Water bucket is conveniently located in the front of the unit for easy access, while the carry handle and splash guard make emptying your bucket hassle-free.
Effortless™ Clean Filter Our antibacterial filter reduces bacteria, room odors and other airborne particles for a cool comfortable environment.
Smells Fresher Washable filter keeps your air smelling fresh. Plus, the dehumidifier prevents odors that result from mold, mildew and bacteria.
SpaceWise® Portable Design Caster wheels and top and side handles make it easy to move your unit from room to room.
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(based on 71 reviews)
Ratings Distribution
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of respondents would recommend this to a friend.
Best Uses
Most Liked Positive Review
Very pleased
I'm using this in my basement which is approximately 1,500 sq feet. Like all basements it felt damp and while it didn't smell like mildew, it had a definate "basement...Read complete review
I'm using this in my basement which is approximately 1,500 sq feet. Like all basements it felt damp and while it didn't smell like mildew, it had a definate "basement smell". I received the unit, unpacked it and within a few minutes the dehumidifier was up and running. It really takes no skill to set up and operate. I was shocked at how quietly it ran. The unit works great! After about two days of operation and emptying 2 times the basement was NOTACABLY less damp and the smell was nearly gone. Instead the air smelled clean, maybe this is due to the filter on the dehumidifier. I have been running the unit continuously for about 3 weeks now and I am so pleased with it's performance. Initially I was going to run a drain hose from the unit. I decided because my basement has several rooms, it was better for me to periodically move the unit from room to room. This sounds like a pain but it really isn't. The hint is so light and portable it's super easy. I think moving it around helped in my case. If you have an open space you wouldn't have to do this. The only thing I wish the unit had was a digital readout of the air's humidity. This isn't a big deal though. Overall the value you get for the price is awesome.
Most Liked Negative Review
Small but noisy -
I use it in the basement but it pales in comparison to my 15 year old 30 pint dehumidifier of a different brand. I see the water in the water pan but the dampness...Read complete review
I use it in the basement but it pales in comparison to my 15 year old 30 pint dehumidifier of a different brand. I see the water in the water pan but the dampness remains in the air. The pan needs to be snapped into place which takes considerable time. Seems more like a toy. Noisy for its size.
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Works as advertised
By Unclear
from Undisclosed
Kicks off some heat but it works very well. Love that the drainage on back uses a regular old garden hose threading, no specialty tubes.
Comment on this review
By Dehumidifer
Seems to be working great! would like another one actually. but can't afford it right now!
Nice unit
By Sferg
We've had this for a couple of months and it's been great. It is reasonably quiet, does the job adequately, is lightweight and easy to clean the filters.
By Herb
I have had this unit for a couple of months and have not had any problems with it. Does the job designed to do.
does the job
By lbjc
effectively removes water from damp basement
Easy replacement
By Jason
We needed a dehumidifier that could run as often as needed and it fit the bill for our basement. In some cases, it ran 24x7 and kept our basement completely dry. It replaced an old dehumidifier and this one is much more energy efficient.
Great product!
By jvilk
Hooked it up to the sump in the basement, and have it set to run when things start getting a bit humid. Appears to work very well so far!
Frigidaire 30 Pint Capacity Dehumidifier
By jazzymag
The Dehumidifier is Great Easy to set up and quiet I love it so much I am going to buy another one
Nice machine!
By Melissa
Very good quality & seems to work great so far!
works great
By the machine
easy to use, nice range of settings
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OXO Egg Slicer
Slice hard-boiled eggs for salads, sandwiches and more with this handy gadget that slices eggs either lengthwise or horizontally. A raised handle makes it easy to open and close the slicer, while a nonslip base keeps the slicer from sliding when in use. Cleans up easily in the top rack of the dishwasher.
- Manufacturer: OXO
- Material: Plastic, stainless steel
- Care: Dishwasher safe
- Dimensions: 6" x 4" x 1½"
- Made in China


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Looking for a second hand dhx5 air that will
l fit my frame: 190mm x 50 mm
Classifieds - Wanted
DHX5 Air
Posted 2 years ago #
I've got one. Hasn't been used for a few years so prob needs a service, but would accept an offer that takes that into account. Am Surrey based if helps.
Posted 2 years ago # -
Replied to mail in profile, thanks.
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