text: This was our fourth year going to Chautauqua for a week's program, but our first time at Tally Ho. I had read the reviews here, and our visit had an ominous beginning. I mailed a deposit check in May for a week in late August, Apartment #7, but got no confirmation. In early August I sent a letter, two emails... More


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New York
Naeem Davis charged in NYC subway rider's deathComment
As New York City strangers pondered what they would do in a similar nightmare situation, authorities charged a homeless man in the death of a Queens resident pushed in front of an oncoming subway train and killed as onlookers watched.
New York City man pushed onto subway tracksComment
The wife of a New York City man who was pushed onto subway tracks to his death by a mumbling stranger says she and her husband had argued before the tragedy.
Dominique Strauss-Kahn hotel maid rape case reaches settlement agreementComment
Word of a settlement agreement between former International Monetary Fund chief Dominique Strauss-Kahn and a hotel maid who accused him of trying to rape her could bring an end to a saga that has tarnished Strauss-Kahn's reputation, ended his hopes for the French presidency and renewed a debate about the credibility of sexual assault accusers.
New York City officer gives homeless man new bootsComment
A tourist's snapshot of a New York City police officer giving new boots to a barefoot homeless man in Times Square has created an online sensation.
Rockefeller Center Christmas tree: NJ spruce lights up as Rockefeller Center tree
Thousands of onlookers crowded behind barricades on the streets that surrounded Rockefeller Center. The tree is illuminated with more than 30,000 lights and topped by a Swarovski star.
New York gas rationing begins in wake of SandyComment
Superstorm Sandy took leave of the East Coast more than a week ago, but the reverberations of the massive storm continue. And relief efforts from the D.C. area continue.
Statue of Liberty lit for first time since SandyComment
The Statue of Liberty was illuminated Friday evening for the first time since it was damaged by Superstorm Sandy. The statue has been closed because of damage resulting from the storm that hit New York Oct. 29, with no estimate on when it will reopen to visitors.
Nor'easter brings more wind, rain to Sandy-torn northeastComment
The nor'easter, as promised, brought gusting winds, rain, snow and the threat of flooding. It menaced travelers with icy roads, snarled the Long Island Rail Road and knocked out power to people who had only recently gotten it back after Superstorm Sandy.
Nor'easter tracking map: New York, New Jersey in path of first winter stormComment
A nor'easter blustered into New York and Jersey on Wednesday, threatening to swamp homes all over again, but the D.C. metro area will be generally spared from the worst.
New York-bound flights canceled: American, United scrap flights ahead of stormComment
Major airlines, including American and United, are scrapping flights in and out of the New York area ahead of the second significant storm in little more than a week.
Nor'easter prompts evacuations in NY, NJComment
New York City officials are warning vulnerable residents about evacuating in the face of possible flooding from another East Coast storm.
Falling temps add urgency to superstorm recoveryComment
More than 2.2 million customers remained without power in several states after Sandy came ashore Monday night.
New York City Marathon canceledComment
New York City officials say the NYC Marathon scheduled for Sunday is canceled.
Staten Island residents feel abandoned in wake of SandyComment
Residents and public officials on Staten Island complained that help has been frustratingly slow to arrive on stricken Staten Island, where 19 have been killed - nearly half the death toll of all of New York City.
Hurricane Sandy: Motorists growing frustrated with long gas linesComment
Motorists fumed in long lines at gas stations around the metropolitan area and screamed at each other Friday morning as fuel shortages hindered the region's efforts to recover from Superstorm Sandy.
Superstorm Sandy may cause $50 billion in damagesComment
Sandy may have caused between $30 billion and $50 billion in total economic losses, including property damage, lost business and extra living expenses.
NYC's subways resumes limited service after stormComment
New York's subways are rolling again - at least, some of them.
Superstorm Sandy slams into New Jersey coastComment
Authorities have launched a rescue effort after a broken levee flooded a small northern New Jersey town early Tuesday.
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Private Practice Scoop: Look Who's Returning!by Matt Richenthal at . Comments
A very familiar face will make an appearance on Private Practice Season 6 before this ABC drama says goodbye.
TV Guide has confirmed that Audra McDonald will reprise the role of Naomi Bennett on the upcoming series finale. The best friend of Addison and ex-husband of Sam moved to New York near the end of Season 4.
In real life, the actress also departed for The Big Apple in order to be closer to her family.
No word yet on what brings Naomi back into the Seaside Wellness picture. A reunion of some kind? A wedding? A funeral?
Take your best guess now.
Matt Richenthal is the Editor in Chief of TV Fanatic. Follow him on Twitter and on Google+.Tags: Private Practice, Casting News, Audra McDonald, Spoilers
Best. News. Ever. I'm so glad she's returning. I'd love for Tm Daly and Chris Lowell to make an appearance even if it's in the form of a flashback or just appearing as a ghost for Betsy, while Pete is some kind of sub-conscious thing for Violet and tells her to move on or something. As for Naomi, hopefully her and Sam will rekindle! That'll be fantastic!
You mean the actress left so she could return to her beloved Broadway and get that sixth tony award.
This is great! Nai has been missed.
Addison and Jake series finale wedding!
So, Im pretty sure I said Naomi 50 times before this page actually came up and confirmed!! Woot Woot! So excited!!


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In nine days, Colorado Springs voters will make history by choosing the city's first strong mayor.
Will it be Steve Bach, 68, a commercial real estate broker who says City Hall needs a fresh perspective?
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In nine days, Colorado Springs voters will make history by choosing the city's first strong mayor.
Will it be Steve Bach, 68, a commercial real estate broker who says City Hall needs a fresh perspective?
Or will it be Richard Skorman, 58, a downtown businessman and former city councilman who says the city needs an experienced hand?
Colorado Springs' next mayor will have to meet high expectations from the public and lead city government through a time of transition under the new strong-mayor form of government.
The next mayor will be the city's chief executive, a position that pays about $96,000, and have broad new powers that include hiring and firing department heads and developing spending priorities.
Much is riding on the next mayor, who will lay the groundwork for a governance structure that is untested in Colorado Springs.
Click here for a profile of Steve Bach.
Click here for a profile of Richard Skorman.
Click here for The Gazette's election page.
Ballots in the city's all-mail runoff election must be returned, not just postmarked, by 7 p.m. May 17, which is Election Day.
Ballots can be returned by mail or dropped off at one of the following locations 8 a.m. to 5 p.m. through May 16 and 7 a.m. to 7 p.m. May 17:
City Clerk's Office, 30 S. Nevada Ave., Suite 101
Colorado Springs Senior Center, 1514 N . Hancock Ave.
Fire Station #8, 3737 Airport Rd.
Fire Station #17, 3750 Tutt Blvd.
Fire Station #19, 2490 Research Parkway
Fire Station #20, 6755 Rangewood Dr.
Gold Hill Police Substation, 955 W. Moreno Ave.
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What inspired you to get involved with this project/organization?
My inspiration to get involved with this project came as a result of mentoring. A female Computer Scientist who came to deliver a career talk in my secondary school when I was a teenager inadvertently mentored me. That was the first time I had ever come across a female Computer Science Professional and I was really amazed that a woman could be so bold and intelligent. I wanted to be like her and decided that I was going to study Computer Science. Having realised my dreams, I decided to become a role model to younger girls and fellow women by reaching out to them through mentoring and ICT related activities. This project is thus an opportunity to give back to the community and mentor others since I am a product of mentoring.
What do you hope to learn from the WeTech Network?
By interacting with women from diverse background and communities who share the same vision than me, I hope to expand my network and obtain new and innovative ideas, which I can later use to impact my community.
What is your big dream for girls and women in STEM?
My big dream for girls and women in STEM is that soon the whole world will see the potential in women and discrimination against women in STEM will become a thing of the past.
What is the goal of your project?
The goals of the camp are to improve female participation and involvement in Computer Science and provide early ICT mentoring for participants.
Who is the target audience for your project?
The camp is targeting secondary school girls as well as female teachers in Oyo State and nearby cities in South-Western Nigeria. The camp will feature successful female leaders in ICT who will share their career experiences and serve as role models for the students. This project is an expansion of the Computer for Girls Camp. The grant is enabling us to increase the number of participants from approximately 30 in the past to 100 girls, who will be camped on-sit throughout. Secondary school teachers will also have the opportunity of participating in the event.
Anything else?
We hope that the camp will boost the participants' confidence by enabling them to create personal ICT projects after undergoing hands-on ICT training.
Watch this video from Yetunde Folajimi
Visit the Nigeria Geek Girls website
© 2014 Institute of International Education, Inc. All rights reserved.


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When crop research news happens, Iowa farmers and agribusiness professionals want to know — and now they know a lot faster, thanks to the Integrated Crop Management (ICM) News Web site. The former printed newsletter has been replaced with an online resource. Gerald Miller, director of ISU Extension to Agriculture and Natural Resources, says the change will help subscribers stay informed about crop issues during the upcoming growing season.
"With the printed version, there would be about a week's delay from the time an article was written to the time the newsletter was received in a subscriber's U.S. mailbox," Miller said.
"With the online resource, a specialist can write an article, and the editor can review it and post it on the Web in only a matter of hours. When an article is posted — whether it's Sunday afternoon, or Friday morning or Monday at noon, subscribers can automatically get an e-mail notice that there's a new article available."
Subscribers can choose to be notified about new articles daily or weekly. They can read articles online as well as print single articles or weekly compilations.
ICM News is supported primarily by ISU Extension and the College of Agriculture and Life Sciences and the departments of Agronomy, Entomology and Plant Pathology. However, Miller said specialists in other areas also could be called in to contribute research-based information.
The needs of Iowa's farmers and agribusiness professionals drive the decisions on what is published in ICM News, Miller said. If they have a need, then ICM News will address it.
For subscription information, visit the ICM News Web site.
This article appeared in April 2008 -- From Jack Payne Newsletter
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Find old friends from
Mcdonnel & East Indoor Cricket Team (Toowoomba)
If youre looking to find an old friend from Mcdonnel & East Indoor Cricket Team then add this attendance to your profile, for a better chance to reconnect with the people you once knew.
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Dates attended : 1985 - 1987


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Put a spin on cocoa by making it in your slow cooker.
Gooseberry Patch OCTOBER 2012
Combine sugar and cocoa in a slow cooker; stir in milk. Cover and cook on low setting for 3 to 4 hours. At serving time, stir in vanilla.
With a whisk or a hand mixer, carefully beat until frothy. Ladle hot cocoa into mugs. Garnish with marshmallows or whipped cream.
Nice & Spicy Cocoa: Add one teaspoon cinnamon and 1/8 teaspoon nutmeg along with the cocoa. Cover and cook as directed.
Mocha Cocoa: Prepare recipe as directed. At serving time, stir 3/4 teaspoon instant coffee granules into each mug of hot cocoa; stir to mix.
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In India, when there is a marriage procession, when the bridegroom is going to collect the bride from her house, all the preparations are the same as for a battle. The bridegroom carries a knife at his waist because in the old days collecting the bride was a kind of kidnapping. There was no love, it was done forcibly: sitting on a horse with a knife and sword the madman goes to get the bride. Is it a sane thing? - a music band and all the trappings of a battle? And the people who follow a marriage procession are all the loafers of the town. People who join in marriage processions lack character. Even if a sane man joins the procession, he goes insane. It has always been the crazy people who make up marriage processions. Why should a sane man go? And if he does go, the craziness will also surface in him.
If you take even good people, even the sanest of people in a marriage procession - they may be ministers, doctors, engineers - you will find that the marriage procession will change something in them. By joining a procession something goes wrong in them, because customarily these men were brought along in the procession to fight for the bridegroom; the girl was to be kidnapped. This is the reason why the father of the bride still bows to the bridegroom; it is an old custom. The only reason behind this bowing down is that he is saying, "There is no need to kidnap the girl, I am ready to surrender, I accept my defeat." This is why the father of the bride is lower and the father of the bridegroom is higher. The bridegroom's family are the winners and the father of the bride is the defeated one.
The marriage procession was coming. Nasruddin was alone near the cremation ground of the village. It was a lonely, silent moment and he became afraid. It was a cemetery, he was already afraid, and his enemies were coming! He jumped over the wall of the cemetery and lay down in a freshly dug grave. He thought: "Who will kill the already dead? The people will pass by and not notice me at all. Who will notice me lying here where there are already so many dead people? And the wall will protect me too."
But the people only saw a man, and that he was suddenly shocked and that he jumped over the wall, so they became suspicious - he appeared to be an enemy, he was hiding. He might throw a bomb, he might do anything! They stopped the music. Then Nasruddin was certain that he was right, and now these people had seen him. He lay still, holding his breath. All the people from the procession came to see, they climbed the wall and started searching for him. Nasruddin became even more afraid: he had been certain that they were after him and now he became absolutely certain: "Why are they not just continuing on their way? Why should they climb the wall?" And when the people saw that this man was lying down in a newly-dug grave, alive and breathing - his belly was moving - they thought, "He is a troublemaker. We don't know what his intentions are." They surrounded the grave and bent over it from all sides. Now, how long could Nasruddin hold his breath? At last he breathed out. Then they asked him, "What are you doing here?"
Nasruddin said, "That is what I want to ask you. What you are doing here?"
They said, "Answer us - why have you come here?"
Nasruddin said, "This is what I want to ask you. You were going along the road, so why have you come here?"
By this time it became clear to Nasruddin, "They are not going to harm me, and I am not going to harm them - we just became afraid of each other." Nasruddin said, "Now I can answer you from my side and also from your side. You are here because of me and I am here because of you."


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Last Sunday at church, during our monthly meal, a young woman named Catherine Rivard presented her ministry to us. She's a linguist and Bible translator who's preparing to go to Papua New Guinea with Wycliffe Bible Translators. Her assignment is to put the Bible into the common language of one of the people groups there, although she's not yet sure which one.
I was surprised to hear that there are over 800 different languages spoken in that small country (about the size of California), over 300 of which do not have the Bible in their language. And Catherine said that these many languages are not similar to one another, that is, they're not dialects but distinct languages. Hard to believe but apparently true.
So when she arrives in June she will first go through a training which will cover (1) culture, (2) language, (3) Bible translation, (4) medical skills, and (5) survival skills--yes, I said survival skills. She may be put in life-threatening situations and they want her to know how to make it out there. I guess it's a "Bible Translator vs. Wild" kind of thing!
I was quite touched to hear it would take 8-20 years to complete the translation project once she starts. This young woman, in the prime of her life, is laying it all down for Christ that others might know him and love him and serve him. and perhaps someday go to other nations for him. May the Lord richly bless her and grant her the power to fulfill her calling.
Here are two links, one to Catherine's blog and the other to Wycliffe.
At this time of year I often commute on my bike and though I know it's going to happen, it never ceases to amaze how the miles pile up. My office is 3.2 miles from my house and then during the day I have to ride here and there for this and that reason, and without even feeling it or even noticing I got home and saw that I had gone 20 miles.
It's not the 20 miles of riding is that much, I do that kind of distance all the time. It's that I just can't believe how the miles pile up when you're just doing random stuff.
Well, not much of a blog today, just something that's been on my mind! Hope you have a great day.
Tuesdays are "strength days" for me at this time of year so yesterday I took a 30 mile ride on a course with some rolling hills and one big climb (for Minnesota that is). After a 15 minute warm up at a cadence of 100 (my normal cadence) I put the chain up in the big ring and push the biggest gear I can at a minimum cadence of 90, preferably 95. I did this for 4 minutes, recovered for two minutes and then repeated 9 times for a total of 10 reps.
The workout went well but doing 10 reps was a bit much. These reps took a total of 60 minutes and I think I would have been better served to have done half that much. My muscles are a bit sore this morning but that's a good thing, it means I got a good workout! However, my knees are aching a little and I know it's not because of poor seat position--I've spent a lot of time getting that just right. Thus, I know they're aching because I pushed too hard for too long and the main reason I changed my riding style to a high-cadence style was because of knee problems.
So overall it was a great ride, I have no regrets, but I will probably only do 5 or so intervals next time.
By the way, thanks MOTOGUY for clarifying my definition of speed. I learned the technical definitions of such things from Joel Friel years ago but often blur them in contexts like this. For those of you who care, here are the technical definitions of power and speed:
Strength + Cadence = Power
Power + Aerodynamics = Speed
Whatever the technical definitions are the point is pretty simple: to go fast on a bike you have to work on cadence, strength, body position, and endurance. I wish all things in life were this simple!
Have a great day!
My training plan for March is essentially the same as April, however, I'm now ramping up the miles from 250 last month to 350 this month. Thus, I plan to take a 30 mile ride today, focusing on building strength. Specifically, I'll be doing 4 minute intervals, with two minutes of recovery, where I push the biggest gear I can at a minimum cadence of 90 rpm. If I go up a brief rise or something it's acceptable to let the cadence dip down to around 85 but only if that lasts for 30 seconds or less.
Speed = strength + cadence. The faster you can spin a bigger gear, the faster you will go! So, that's what today's workout is all about, I'll write tomorrow to let you know how it goes.
Have a great day, Lord have mercy on us.
I blogged this morning about the death of Osama bin Laden. Here's the link if you want to check out my blog and here's the text if you don't.
I've been praying for Osama bin Laden for nearly ten years now. Even as I write I'm remembering several prayer meetings wherein we pleaded with the Lord to reveal himself to this man. Don't get me wrong, I abhor the life he lived and I grieve at what he's done. I, like most Americans, was outraged on 9/11/01 and wanted him to pay for his actions with his life. And yet, as I processed my feelings with the Lord I came to see that my sin is also great and that bin Laden, like me, was in need of a Savior. So I began to pray for him and hope against hope that Christ would win glory for himself by pouring his mercy upon him.
I didn't hear the news until this morning. Part of me doubted it was true. Part of me rejoiced that justice has been done. Part of me grieved that a lost soul could no longer be saved and is now in hell where he will grieve and gnash his teeth forever.
Whatever your reaction to his death, be careful not to rejoice too much, and be sure to search your own soul. Consider the words of Jesus from Luke 13:1-9.
"There were some present at that very time who told him [Jesus] about the Galileans whose blood Pilate had mingled with their sacrifices. And he answered them, 'Do you think that these Galileans were worse sinners than all the other Galileans, because they suffered in this way? No, I tell you; but unless you repent, you will all likewise perish. Or those eighteen on whom the tower in Siloam fell and killed them: do you think that they were worse offenders than all the others who lived in Jerusalem? No, I tell you; but unless you repent, you will all likewise perish.'
"And he told this parable: 'A man had a fig tree planted in his vineyard, and he came seeking fruit on it and found none. And he said to the vinedresser, "Look, for three years now I have come seeking fruit on this fig tree, and I find none. Cut it down. Why should it use up the ground?" And he answered him, "Sir, let it alone this year also, until I dig around it and put on manure. Then if it should bear fruit next year, well and good; but if not, you can cut it down."'"


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In celebration of May as Water Awareness Month, Angels Baseball honored the winners of Anaheim Public Utilities' 23rd annual Water Conservation Poster Contest. The young artists, first through sixth-grade students from Anaheim elementary schools, received trophies during a pre-game ceremony on the field prior to the game against the Kansas City Royals.
The winning posters have been on exhibit in the lobby of Anaheim West Tower, 201 S. Anaheim Blvd., for the month. Winners, by grade level, are:
•First grade
Andrew Soto, Acaciawood Private School
Joshua Lou, Acaciawood Private School
Alisa Kangas, Acaciawood Private School
•Second grade
Arielle Kayekjian, Acaciawood Private School
Christina Espinosa, Acaciawood Private School
Courtnie Bui, Fairmont Private School
•Third grade
Eliana Nava, Acaciawood Private School
Mehkayla Madamba, Centralia Elementary School
Sarah Carvajal, Acaciawood Private School
•Fourth grade
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Keep it civil and stay on topic. No profanity, vulgarity, racial slurs or personal attacks. People who harass others or joke about tragedies will be blocked. By posting your comment, you agree to allow Orange County Register Communications, Inc. the right to republish your name and comment in additional Register publications without any notification or payment.


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Beware of social media experts
Now that social media is reaching its popularity peak, the market is flooded with so-called "experts" and "guru's".
I always wondered why people would call themself "expert" or "guru"..
I played with social media since 2006. For the past two years, much of my work involved social media. For the past year, I have done little but social media.
While I might know a bit more than the average Joe-in-the-street, I can't call myself an "expert", leave alone "guru".
The more I work in social media, the more I realize what there is to learn. The longer I am involved in social media, the more tools and tricks I discover, and the more I realize how much there is "out there".
When I give training on social media, I am always amazed about things the trainees come up with. I seem to learn as much as they do.
And yet, the longer I work in social media, the more I am confronted with dudes who pretend to know it all. Often they are closed for input, feedback, or criticsm. Which is a bad sign, as if they don't want to rock their own foundations of self-confidence. I love people who are able to doubt.
So good people out there, beware of "social media experts". In a rapid evolving world, as social media is, the more one learns, the more one discovers how much there is to know.
Picture courtesy Bits or Pieces?


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Stussy has released the new "Island" snapback caps as part of its Summer 2014 collection. Featuring an all-over floral print pattern, the cap is available in two colors and features a woven Stussy script logo patch on the front panels. Priced at $34 you can get the caps now directly from Stussy here.
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Locality Updated: Veľká Poľana, Snina Co., Prešov Region, SlovakiaFrom Matúš Škutka, 22nd Dec 2014 12:56:29


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Rabbi David Ellenson, Ph.D., President of Hebrew Union College-Jewish Institute of Religion (HUC-JIR), has announced the Class of 2009, who will be ordained, invested, and graduated this spring in Cincinnati, Los Angeles, and New York. HUC-JIR is the nation's oldest institution of higher Jewish education and the academic, spiritual, and professional leadership development center of Reform Judaism.
The rabbinical and cantorial graduates of the New York School of HUC-JIR will be ordained and invested, respectively, at Ordination and Investiture Services at Congregation Emanu-El of the City of New York on May 3rd.
Fourteen rabbis (11 women, 3 men) will be ordained (of 43 rabbinical graduates of the Class of 2009 – 13 men, 30 women) and 11 cantors (9 women, 2 men) will be invested at the convocation marking the 134th academic year. Rabbi Norman Cohen, HUC-JIR Provost, will deliver the Ordination Address.
Rabbi Ellenson will award the 2009 Roger E. Joseph Prize to Helen Lieberman, Founder of Ikamva Labantu, the South African non-profit organization that works with and assists affiliated community-based organizations serving children, youth, adults, families, seniors, and the disabled.
Rabbi Ellenson said, "The Class of 2009 emerges from the College-Institute imbued with leadership skills, steeped in knowledge, strengthened by a commitment to service, and dedicated to bringing hope and healing to our troubled world. As they touch the lives of others through their sacred work as rabbis, cantors, educators, communal professionals, scholars, and pastoral care-givers throughout North America and around the world, they will be a source of inspiration and guidance."
The students to be ordained rabbi are:
Judith Bacharach
Stephanie Bernstein
Carolyn Bricklin
Rebecca Cottle
Jill Cozen-Harel
Jordana Gerson
Erin Glazer
Helayne Shalhevet
Jo Hirschmann
Beth Kalisch
Kevin Kleinman
Rachel Larkin
Joseph Murray
Adam Rosenwasser
The students to be invested cantor are:
Lisa Shapanka Arbisser
Rachel Berney
Shira Ginsburg
Zoe Jacobs
Marcy Kadin
Aaron Kaplan
Sharon Kunitz
Arik Luck
Rebecca Moses
Katie Oringel
Jennifer Strauss-Klein
Please see the national invitation for full event details (http://huc.edu/external/email/09/03/graduation/).
Founded in 1875, Hebrew Union College-Jewish Institute of Religion is North America's first institution of higher Jewish education and the academic, spiritual, and professional leadership development center of Reform Judaism. HUC-JIR educates men and women for service to North American and world Jewry as rabbis, cantors, educators, and nonprofit management professionals, and offers graduate programs to scholars and clergy of all faiths. With centers of learning in Cincinnati, Jerusalem, Los Angeles, and New York, HUC-JIR's scholarly resources comprise the renowned Klau Library, the American Jewish Archives, research institutes and centers, and academic publications. In partnership with the Union for Reform Judaism and the Central Conference of American Rabbis, HUC-JIR sustains the Reform Movement's congregations and professional and lay leaders. HUC-JIR's campuses invite the community to cultural and educational programs illuminating Jewish heritage and fostering interfaith and multiethnic understanding. www.huc.edu


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Author Archives: David Anderson
Hockey returns to Indianapolis tonight. And David Anderson will be there "to welcome back the Komets with open arms… and extended middle fingers."
Tagged Hockey, Indiana, indianapolis, Sports
"For Kentuckians who are here for the first time, we've compiled a list of attractions for before and after the big games." David Anderson demonstrates Hoosier Hospitality.
Tagged Basketball, Indiana, indianapolis, Kentucky, NCAA, Pacers, Sports
"So, as Ohio State and Dayton take the court, we excuse ourselves from the office to gather on sticky floors in dark bars to order chicken wings with signature sauce." David Anderson invokes the Madness.
Tagged Basketball, Humor, Sports
"In case drizzling sleet isn't depressing enough, is everybody aware that, as of today, there are exactly zero Indiana schools likely to make the NCAA Basketball Tournament?" David Anderson thinks we need a law.
"The NFL has been tinkering with its playoff structure for almost a century and now, more than ever, it's a crapshoot." David Anderson offers some analysis–and a bit of historical perspective.
Tagged Andrew Luck, Football, indianapolis, Peyton Manning, Sports
"The second weekend in September has been officially declared the third best weekend to get a vasectomy." What does this have to do with sports? David Anderson has your answer.
"Don't let anybody talk you into anything less than the commode that can flush 18 golf balls. Throw away the plunger." David Anderson makes a game of thrones.
Tagged bathroom humor, Humor, toilets
"Where are the cries that the farm lobby is driving us to the brink of socialism? Are we willing to ask whether Indiana farmers need $183 million in annual direct payments? Would we feel the same about direct payments if Henry County was 96.2% minority?" David Anderson is just asking.
Tagged Advertising, Farming, Indiana, Politics
"On the precipice of another epic adventure, sixty-three games in twenty-two days, it is only appropriate that in Indiana, where it is religion, we ask the basketball gods to look over us and bless our men of twists and turns on the hardwood floors of this great country." Sing it, David Anderson.
Tagged Basketball, Indiana, NCAA, Religion
"When Sylvester Stallone makes a shitty movie (link to any of a dozen movies), Sly doesn't tell people he 'deserves' the support of his fans. Sports are entertainment, and the product needs to provide entertainment value." The fans (aka David Anderson) write back.
Tagged Basketball, Indiana, indianapolis, Pacers, Sports


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TCF Inventory Finance, Inc. Appoints U.S. And Canadian Leaders In PowerSports Industry
TCF Inventory Finance, Inc. ("TCFIF"), a subsidiary of TCF National Bank and an indirect subsidiary of TCF Financial Corporation ("TCF") (NYSE: TCB), has named Scott Raymond as General Manager for the powersports industry in the United States, and Peter Kelley as General Manager for the powersports industry in Canada. Together, they will lead TCFIF's efforts to further expand its base of powersports manufacturers and dealers across North America.
"Scott and Peter both have extensive experience in floorplan financing as well as a deep understanding of the powersports industry," said Ross Perrelli, President and Chief Executive Officer of TCFIF. "I have tremendous confidence in their abilities to lead and bring new customers on board."
TCFIF recently gained significant ground in the powersports finance market when it entered into a multi-year exclusive agreement with BRP to provide inventory financing to its U.S. and Canadian Ski-Doo®, Sea-Doo® and Can-Am® dealers. They are also the preferred finance provider for BRP's Evinrude® and Johnson® dealers across the U.S. and Canada. Additionally, TCF Commercial Finance Canada, Inc. remains the exclusive provider of inventory floorplan financing for Arctic Cat's Canadian dealers.
Kelley, who has been with TCFIF since the company's inception in 2008, remains the President of TCF Commercial Finance Canada, Inc., but will focus his efforts on the Canadian powersports industry for the near future.Raymond joined TCFIF in June 2009 and is based in the company's Alpharetta, Georgia office. Over the past three years, he has been focused on the U.S. lawn and garden and specialty finance businesses, and has extensive experience in development and leadership of significant powersports financing programs. For powersports manufacturer and dealer inquiries in the U.S., please contact Scott Raymond at (770) 754-7330, or at email@example.com . For powersports manufacturer and dealer inquiries in Canada, please contact Peter Kelley at (877) 800-4430, or at firstname.lastname@example.com . About TCF Inventory Finance, Inc.TCFIF is a premier inventory finance company offering a full range of inventory financing solutions to manufacturers, distributors and their dealers throughout the United States and Canada in the lawn and garden industry, the powersports industry, the recreation vehicle industry, the marine products industry and the consumer electronics and appliances industry. For more information about TCFIF, please visit www.tcfif.com. About TCF Financial CorporationTCFIF is an indirect subsidiary of TCF, a Wayzata, Minnesota-based national bank holding company with $17.8 billion in total assets at March 31, 2012. The company has over 430 branches in Minnesota, Illinois, Michigan, Colorado, Wisconsin, Indiana, Arizona and South Dakota, providing retail and commercial banking services. TCF also conducts commercial leasing and equipment finance business and leverage lending in all 50 states, commercial inventory finance business in the U.S. and Canada, and indirect auto finance business in over 30 states. For more information about TCF, please visit www.tcfbank.com. Photos/Multimedia Gallery Available: http://www.businesswire.com/cgi-bin/mmg.cgi?eid=50318262&lang=en
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pros: easy to install on the weaver rail, ready to take down any target. con: i have none If you are looking for a new front sight on a same plane rail this will fit the bill. Read more
Excellent Sight for my HK416 Airsoft Rifle, allows you fast install locations on the forearm of weapons (to picatinny locking slot - the spacing of slot centers is 0.394in. (10.01 mm)) so as not to discomfort with his retention, the included hex key allows you fast and secure fixate the Front Sight in ... Read more
Well its cheap and easy to put on. The front sight post (the little pin that you actually line up with a rear sight for aiming) is crooked. Very crooked. The hole it screws into was probably drilled crooked. I could probably bend it with pliers, but it adjusts by rotating, so that would just make it ... Read more


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main index
A casual MMO by Three Rings, the makers of Puzzle Pirates.The members of an unidentifiable race have crash-landed on the hostile planet Cradle. This ain't your standard planet, either. Just below the surface is a huge steampunk dungeon full of monsters, traps, whirling gears and energy fields. As a Spiral Knight equipped with swords, guns, or bombs, you must join up with other players to fight off the many enemies that would see your kind wiped off the planet and make your way down to the glowing core of the planet: an energy source powerful enough to restart their space ship.Gameplay is a semi-top-down Hack and Slash mixed with a Shoot 'em Up in the form of a Dungeon Crawler, and it's often compared to the 2D The Legend of Zelda games. Players can adventure through the clockworks on their own or join a team of up to 4 people. Despite looking very peaceful and simple at first glance, the game can be rather difficult, especially in later parts of the game. Enemies can dish out large amounts of damage if their attacks hit you and bosses require a fair amount of teamwork. The game has no Experience Points, your power level (and thus what areas the game will allow you into) is determined purely by the equipment you have. There is a heavy emphasis on Item Crafting, with the best items being synthesized from materials found in the dungeons.The game is free to play, but energy can be purchased for real money (or from other players for in-game currency) to unlock some premium features such as carrying additional weapons. It is implemented in Java and can run in a browser window or full screen, and runs very well for a full 3D game even on low-end computers.Available here. On June 14, 2011, it became available on Steam as one of its first free-to-play games.Not to be confused with the other kind of Spiral Knight.


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Multiple Sclerosis (etiology)
Study explores link between MS and uveitis(22/10/14)
A joint study by researchers from Germany and the US has found that nearly 60% of patients with multiple sclerosis (MS) and uveitis were diagnosed with each condition within five years.
Researchers from the Oregon Health and Science University in the US and the University of Heidelberg in Germany, examined the records of uveitis patients from each university. The study, which is the largest retrospective study of MS in uveitis patients, examined data taken from over 8,000 patients between 1985 and 2013.
The teams found that MS was 18 times more likely to occur in Americans with uveitis and 21 times more likely to occur in Europeans with uveitis, than in those general populations without uveitis.
The study also showed that MS was diagnosed in 29% of patients before uveitis was diagnosed, both MS and uveitis were diagnosed simultaneously in 15% of patients, and MS was diagnosed after uveitis in 56% of patients.
Wyatt Messenger, from the Oregon Health and Science University, who led the research, said: "With a population size four-times larger than any study to date on this topic, our study provides a wealth of clinical information.
"Knowing more about the onset of MS may enable patients to seek treatment earlier, therefore slowing the progression of the disease and limiting the damage done to the nervous system."
Source: American Academy of Ophthalmology (22/10/14)
Could Multiple Sclerosis begin in the gut?(08/10/04)
MS researchers are focusing on the content of the gut's microbiome as a possible contributor to the body's autoimmune attack on its nervous system.
Multiple sclerosis (MS) is an electrical disorder, or rather one of impaired myelin, a fatty, insulating substance that better allows electric current to bolt down our neurons and release the neurotransmitters that help run our bodies and brains. Researchers have speculated for some time that the myelin degradation seen in MS is due, at least in part, to autoimmune activity against the nervous system. Recent work presented at the MS Boston 2014 Meeting suggests that this aberrant immune response begins in the gut.
Eighty percent of the human immune system resides in the gastrointestinal tract. Alongside it are the trillions of symbiotic bacteria, fungi and other single-celled organisms that make up our guts' microbiomes. Normally everyone wins: The microorganisms benefit from a home and a steady food supply; we enjoy the essential assistance they provide in various metabolic and digestive functions. Our microbiomes also help calibrate our immune systems, so our bodies recognize which co-inhabitants should be there and which should not. Yet mounting evidence suggests that when our resident biota are out of balance, they contribute to numerous diseases, including diabetes, rheumatoid arthritis, autism and, it appears, MS by inciting rogue immune activity that can spread throughout the body and brain.
One study presented at the conference, out of Brigham and Women's Hospital (BWH), reported a single-celled organism called methanobrevibacteriaceae that activates the immune system is enriched in the gastrointestinal tracts of MS patients whereas bacteria that suppress immune activity are depleted. Other work, which resulted from a collaboration among 10 academic researcher centers across the U.S. and Canada, reported significantly altered gut flora in pediatric MS patients while a group of Japanese researchers found that yeast consumption reduced the chances of mice developing an MS-like disease by altering gut flora.
Sushrut Jangi, a staff physician at Beth Israel Deaconess Medical Center in Boston who co-authored the BWH study, thinks that regional dietary influences might even be at play. "The biomes of people living in different areas and who consume Western versus non-Western diets are demonstratively different," he says. "People who emigrate from non-Western countries, including India, where MS rates are low, consequently develop a high risk of disease in the U.S. One idea to explain this is that the biome may shift from an Indian biome to an American biome," although there is not yet data to support this theory.
The microbiome theory is gaining so much steam in academia that a coalition of four U.S. research centers called the MS Microbiome Consortium recently formed to investigate the role of gut microorganisms in the disease. The group presented data in Boston showing significantly different gastrointestinal bacterial populations in patients treated with the MS drug glatiramer acetate compared with untreated subjects. How exactly the drug suppresses MS activity is unknown but the findings suggest that perhaps it works in part by altering gut flora and, as a result, suppressing abnormal immune activity. "The gut is well-positioned for an important role in the development of autoimmune disease, including MS.," says Ilana Katz Sand, an assistant professor of neurology at Mount Sinai Medical Center in New York City and member of the MS Microbiome Consortium. "But important questions remain, such as how MS medications affect the microbiome, how an individual's microbiome may affect treatment responses, whether particular bacterial species are associated with more severe disease and ultimately whether we can manipulate the microbiome to benefit our patients."
Katz Sand says that dietary and probiotic approaches to treating MS are worth pursuing, as is a less palatable approach: fecal transplantation. Yet answers in science and medicine are rarely simple, she added, pointing out that in all likelihood MS arises from a complicated confluence of genetic and environmental influences that might ultimately trigger autoimmune activity. Beyond just our gut flora well over 100 genetic variants—many related to immune function—are now known to contribute to the disease as are external factors including vitamin D deficiency (MS is more common at higher latitudes), smoking and increased salt intake.
Further confounding our ability to pinpoint root causes is that our genetic code influences how our bodies and brains respond to these external factors. It could be that both genes and environmental stimuli lead to pathologic microbiomes or that some unfortunate combination of these factors leads to a common autoimmunologic pathway that ravages myelin. "We know the microbiome shapes our immune system and that MS is an immune-mediated disease. We also know that genes influence our microbiomes and immune systems," says David Hafler, professor of neurology and immunobiology at Yale University School of Medicine who was at the conference but not involved in the microbiome work presented. But there must be nongenetic factors contributing to the disease, too, given that the incidences of MS and other autoimmune disorders are increasing.
"Maybe it's a lot of little factors like low vitamin D, increased body mass index and increased salt intake," Hafler says, "but I wouldn't be surprised if it was one big thing, much like how H. pylori was found to cause ulcers. No one's identified a clear bug that's driving MS but I think it's important we keep looking."
Source: Scientific American © 2014 Scientific American, a Division of Nature America, Inc (08/10/04)
Categorisation of multiple sclerosis relapse subtypes by B cell profiling in the blood(25/09/14)
Introduction: B cells are attracting increasing attention in the pathogenesis of multiple sclerosis (MS). B cell-targeted therapies with monoclonal antibodies or plasmapheresis have been shown to be successful in a subset of patients.
Here, patients with either relapsing-remitting (n = 24) or secondary progressive (n = 6) MS presenting with an acute clinical relapse were screened for their B cell reactivity to brain antigens and were re-tested three to nine months later. Enzyme-linked immunospot technique (ELISPOT) was used to identify brain-reactive B cells in peripheral blood mononuclear cells (PBMC) directly ex vivo and after 96 h of polyclonal stimulation.
Clinical severity of symptoms was determined using the Expanded Disability Status Scale (EDSS).
Results: Nine patients displayed B cells in the blood producing brain-specific antibodies directly ex vivo. Six patients were classified as B cell positive donors only after polyclonal B cell stimulation.
In 15 patients a B cell response to brain antigens was absent. Based on the autoreactive B cell response we categorised MS relapses into three different patterns.
Patients who displayed brain-reactive B cell responses both directly ex vivo and after polyclonal stimulation (pattern I) were significantly younger than patients in whom only memory B cell responses were detectable or entirely absent (patterns II and III; p = 0.003). In one patient a conversion to a positive B cell response as measured directly ex vivo and subsequently also after polyclonal stimulation was associated with the development of a clinical relapse.
The evaluation of the predictive value of a brain antigen-specific B cell response showed that seven of eight patients (87.5%) with a pattern I response encountered a clinical relapse during the observation period of 10 months, compared to two of five patients (40%) with a pattern II and three of 14 patients (21.4%) with a pattern III response (p = 0.0005; hazard ratio 6.08 (95% confidence interval 1.87-19.77).
Conclusions: Our data indicate actively ongoing B cell-mediated immunity against brain antigens in a subset of MS patients that may be causative of clinical relapses and provide new diagnostic and therapeutic options for a subset of patients.
Author: Christopher HohmannBianca MillesMichael SchinkeMichael SchroeterJochen UlzheimerPeter KraftChristoph KleinschnitzPaul V LehmannStefanie Kuerten Credits/Source: Acta Neuropathologica Communications 2014, 2:138
Source: 7thSpace Interactive © 2014 7thSpace Interactive (25/09/14)
Retinal thinning oarallels neurodegeneration in MS(12/09/14)
The thinning of the retina that occurs during the course of multiple sclerosis (MS) closely parallels brain atrophy and may be used to measure neurodegeneration, a new study has shown.
Presenting the data here at MSBoston 2014, the 2014 Joint Americas and European Committees for Treatment and Research in Multiple Sclerosis (ACTRIMS/ECTRIMS) meeting, Shiv Saidha, MD, Johns Hopkins Hospital, Baltimore, Maryland, explained that previous studies had correlated retinal thinning with global disability and brain atrophy, but these studies were primarily cross-sectional in design.
"Our study is groundbreaking in that it is the first ever longitudinal study to look at how retinal changes measured by optical coherence tomography (OCT) track with MRI measures of brain atrophy," he said. "These results could have far-reaching implications for the field of neurodegeneration."
"We showed clearly that the degree of retinal layer thinning predicts the loss of brain tissue. Patients who lost the most neurons in the retina had the highest amount of brain loss on MRI."
He added: "It was particularly effective in patients with progressive MS, but it can be used from the very beginning to identify which patients are deteriorating the fastest."
The MS field has suffered from a lack of tools to track neurodegeneration, and much work is underway to identify such markers, Dr. Saidha added. "Our data shows that measuring changes in the retina with OCT is one of the most promising techniques for this purpose."
"It is easy to do — it takes just 5 minutes to assay the retina," he commented to Medscape Medical News. "It is cheap and easily reproducible. In my view, it is very encouraging."
Validation for Use in Clinical Trials
These opinions were echoed by the chair of the Young Investigators session at which Dr. Saidha presented the study, Patrick Vermersch, MD, Centre Hospitalier Régional Universitaire de Lille, France.
"This study is really interesting," he told Medscape Medical News. "This methodology adds complementary information to explain the neurodegenerative process in MS. Measuring retinal thinning with OCT is much easier than trying to assess brain atrophy with MRI. It is already being used as a marker of treatment response in therapeutic trials, but this study gives validation that this is an appropriate marker to measure."
Dr. Vermersch suggested that OCT may not be as sensitive as measuring brain atrophy with MRI, but it is far more convenient. "I would think MRI will be superior, but it is not widely available," he added. "It is not possible to measure brain atrophy in routine clinical practice — the specific software is only available in specialist centers for research use at present. But OCT is widely available and easy to use."
For the study, 108 MS patients underwent OCT every 6 months (average follow-up duration, 42 months) and annual MRI (3T) of the brain (average follow-up duration, 39 months). Patients with optic neuritis during the study were excluded. Individual-specific rates of change in retinal and brain measures were correlated after adjustment for age, sex, disease duration, and optic neuritis history.
Results showed that the thickness of the ganglion cell layer plus inner plexiform layer of the retina together (GCIP) had the best correlation to whole brain atrophy, with a correlation coefficient of 0.449. GCIP loss was also correlated to atrophy in gray matter (r = 0.371), white matter (r = 0.285), and thalamic (r = 0.379) regions of the brain over time.
Best in Secondary Progressive Disease
The correlation between GCIP and brain atrophy rates was stronger in secondary progressive MS (r = 0.730) and primary progressive MS (r = 0.542) than in relapsing-remitting MS (r = 0.328).
"Although the association between GCIP and brain atrophy in relapsing-remitting MS is impressive, the association in progressive MS, particularly secondary progressive MS, appears to be exceptional," Dr. Saidha stated.
The relationship between GCIP and brain atrophy was affected by history of optic neuritis, which reduced the strength of the correlation, especially in the relapsing-remitting population.
Dr. Saidha reported that for every yearly change of 1 micron in GCIP thickness there was a 0.45% yearly brain loss in eyes without a history of optic neuritis. GCIP atrophy also mirrored lesion accumulation in MS, although this was not as strong as the relationship with brain atrophy.
"Our findings confirm the utility of OCT for tracking subclinical as well as clinical disease progression in MS and establish a role for OCT in clinical trials for the objective investigation of neuroprotection," Dr. Saidha concluded.
Primary Source: MSBoston 2014: 2014 Joint Americas and European Committees for Treatment and Research in Multiple Sclerosis (ACTRIMS/ECTRIMS). Abstract Y12.2. Presented September 10, 2014.
Source: Medscape Multispeciality © 1994-2014 by WebMD LLC (12/09/14)
Visual system as a predictor of change from CIS to MS(10/09/14)
Evaluation of visual structural and functional factors that predict the development of multiple sclerosis in clinically isolated syndrome patients.
Perez-Rico C, Ayuso-Peralta L, Rubio-Pérez L, Roldán-Díaz I, Arévalo-Serrano J, Jiménez Jurado D, Blanco R.
PURPOSE. To evaluate visual pathway structure and function in patients with clinical isolated syndrome (CIS) using spectral domain optical coherence tomography (OCT) and multifocal visual evoked potentials (mfVEP), predicting CIS conversion to clinically definite multiple sclerosis (MS).
METHODS. This observational, longitudinal study assessed the eyes with no prior history of optic neuritis of twenty-nine consecutive patients with CIS according to the McDonald criteria. The relationships of the mfVEP results with the clinical findings, psychophysical (Humphrey perimetry) and structural (OCT) diagnostic test data were investigated.
RESULTS. The mfVEP amplitude responses (interocular and monocular probability analysis) showed abnormal cluster visual field defects in 48.3% of the CIS eyes, while mfVEP latency analysis showed significant delays in 20.7%. OCT average RNFLT (retinal nerve fiber layer thickness) was significantly reduced compared to the control group (P = 0.02). Significant differences between CIS eyes with abnormal and normal mfVEP latencies were found for the OCT RNFLT (P < 0.001) with a longer latency being linked to more severe axonal damage. Using multivariate logistic regression analysis, OCT average RNFLT was found to be independent predictor of clinically definitive MS diagnosis at twelve months.
CONCLUSIONS. The combined use of OCT and mfVEP is helpful to detect significant subclinical visual pathways abnormalities and axonal loss in CIS patients. Retinal axonal loss measured by OCT is an important prognosis factor of conversion to MS in patients with clinically isolated syndrome in absence of symptomatic optic neuritis.
Source: Invest Ophthalmol Vis Sci. 2014 Sep 4. pii: IOVS-14-14807. doi: 10.1167/iovs.14-14807 © 2014 by Association for Research in Vision and Ophthalmology & Pubmed PMID: 25190654 (10/09/14)
Is the intestinal barrier damaged in MS?(05/09/14)
Researchers at Lund University in Sweden have published new research findings on the role of the intestinal barrier in the autoimmune disease multiple sclerosis (MS).
Within medical science, it is not known for certain how MS develops or why the body's immune system attacks cells in the central nervous system. Inflammation develops for an unknown reason, which hinders transport of neural impulses. This can produce various physical and mental symptoms, including a loss of sensation, motor difficulties, blurred vision, dizziness and tiredness.
The present study investigates whether the function of the intestines is also attacked in MS. The results, obtained from a disease model of MS in mice, shows inflammation and changes in the barrier function of the intestines early in the course of the disease. The study has been published in the scientific journal PLOS ONE.
"We know that the permeability of the intestines to harmful substances is raised in inflammatory bowel diseases such as Crohn's disease and ulcerous colitis, as well as in some other autoimmune diseases such as type 1 diabetes. The condition is called 'leaky gut syndrome'. Our studies indicate a leaky gut and increased inflammation in the intestinal mucous membrane and related lymphoid tissue before clinical symptoms of MS are discernible. It also appears that the inflammation increases as the disease develops", said Shahram Lavasani, one of the authors of the study.
Dr Lavasani and his colleagues at Lund University have previously shown that probiotic bacteria could give a certain amount of protection against MS. They therefore wondered whether the intestinal barrier is affected and decided to investigate inflammatory cells and processes in the intestine. The hypothesis was tested in a research project in collaboration with Professor Björn Weström, doctoral student Mehrnaz Nouri and reader Anders Bredberg.
"To our surprise, we saw structural changes in the mucous membrane of the small intestine and an increase in inflammatory T-cells, known as Th1 and Th17. At the same time, we saw a reduction in immunosuppressive cells, known as regulatory T-cells. These changes are often linked to inflammatory bowel diseases, and biologically active molecules produced by Th1 and Th17 are believed to be behind this damage to the intestines."
Neuroinflammatory processes in MS are believed to lead to damage and leakage in the blood-brain barrier that protects the central nervous system and regulates the transport of cells. The researchers have now observed similar damage in the intestinal barrier, especially to the 'tight junctions' that bind the cells together in the mucous membrane of the intestine, and have demonstrated that these are connected to disease-specific T-cells.
"In most cases, we don't know what triggers autoimmune diseases, but we know that pathogenic cells frequent and disrupt the intestines. A leaky gut enables harmful bacteria and toxic substances in the body to enter the intestine, which creates even more inflammation. Our findings provide support for the idea that a damaged intestinal barrier can prevent the body ending an autoimmune reaction in the normal manner, leading to a chronic disease such as MS", said Dr Lavasani.
Shahram Lavasani and his colleagues believe that future drugs to treat this type of disease should perhaps not only focus on the central nervous system, but also on the intestines by repairing and restoring the intestinal barrier.
"In the long run, we hope that our findings will lead to better understanding of what actually happens in the development of MS. Looking even further to the future, we hope for the development of a better treatment that aims at the intestinal barrier as a new therapeutic target."
The research group is now studying other inflammatory parameters in the gut that could affect the development of MS. Their aim is to draw up treatment methods that can heal the mucous membrane in the intestine in the hope of preventing the development of the disease. Some of this work forms part of Mehrnaz Nouri's thesis, which will be defended later in the year.
Full Article - 'Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells.'
Source: Lund University (05/09/14)
Mouse model EAE is not a useful multiple sclerosis model - study(19/08/14)
EAE is not a useful model for demyelinating disease
Peter O. Behanemail, Abhijit Chaudhuri
Experimental allergic encephalomyelitis (EAE) is the commonest, readily induced, organspecific, autoimmune disorder of laboratory animals of its kind.
It is an artificial disorder brought about by the immunisation of susceptible animals with brain antigens in complete Freund?s adjuvant (CFA).
Variations can be induced by altering the nature of the antigen and the conditions involving immunisation.
Whilst it is often described as a demyelinating disease, in strict terms it is not, since the primary pathologic process is not demyelination but rather an encephalomyelitis that is immunologically induced. Rather, the prototype demyelinating disease is multiple sclerosis and its variants.
In this paper, the central question we ask is whether the data gleaned from the EAE model contributes to our understanding of the pathological events in MS.
Towards answering this, we describe the historical development of EAE and its hyperacute form, and discuss the findings studied extensively in the non-human primate which show that ordinary EAE is an exact model for ADEM in the human, and that the hyperacute form of EAE is represented by AHLE in the human. Additionally, we shall comment on the latest research on new variants of EAE, and explain our opinion regarding the use of EAE models in research aiming to understand the pathogenesis of multiple sclerosis.
Full article.
Source: Multiple Sclerosis and related disorders Copyright © 2014 Elsevier Inc (19/08/14)
Researchers look to improve understanding of complex brain(17/02/14)
Understanding the human brain could provide the foundation to explore new ways to treat and eventually prevent diseases such as multiple sclerosis, Parkinson's or Alzheimer's disease, according to the European Brain Council (EBC).
The brain is at the centre of exciting but challenging new times in neuroscience research.
"We have already identified a lot of gaps in knowledge about treatments of brain diseases," said Gordon Francis, head of the NeuroInflammation Clinical Science Unit within the NeuroScience Franchise at the Swiss pharmaceutical company Novartis.
Francis was addressing a conference on Friday (14 February) focusing on brain-related issues in Barcelona, Spain, which advocated for a "brain-political road map" under the motto 'Understanding the brain: Where are we in 2014?'
Among the challenges that scientists are looking into are the loss of brain tissues which for example occur at very early stages of multiple sclerosis and dealing with the changes of brain volume, said Frederik Barkhof, professor of Neuroradiology at the VU University Medical Centre in Amsterdam.
Multiple sclerosis
According to data by the European Multiple Sclerosis Platform, at least 600,000 people in Europe are affected by multiple sclerosis, an autoimmune disease of the central nervous system.
The crippling disease, which strikes the white matter of the brain and spinal cord and affects the rest of the nervous system, has far-reaching consequences for society as more than one million people are affected indirectly through their role as carers and family members, the EMPS said.
However, despite its importance, knowledge on how the brain works is still very limited. According to researchers, understanding the complex brain could provide the foundation to explore new ways to treat, cure and eventually prevent brain diseases such as multiple sclerosis, Parkinson's or Alzheimer's disease.
"We don't want this to be a race or competition against cancer, cardiovascular diseases or diabetes," Mary Baker, president of the European Brain Council, told EurActiv.
"But it is the brain that manages cancer, cardiovascular diseases and diabetes. The brain is a very special organ, we must take care of it," Baker added.
A disease like multiple sclerosis significantly impacts on the quality of life of patients and their families. For example, less than 50% of people with multiple sclerosis will be employed 10 years after receiving their diagnosis. About one-third of people will also need a wheelchair within 20 years of developing multiple sclerosis, according to data published by the Multiple Sclerosis Foundation.
"We try to mobilise the key actors, among them the European Commission's DG Research, on the need for innovation (with news drugs), but also on the social impact of multiple sclerosis," Baker stressed.
Economic and social costs of brain diseases
According to the EBC, the direct cost of healthcare related to brain diseases has increased from €386 billion in 2004 to €798 billion in 2010, measured across 30 European countries.
This means "more money is spent into brain diseases than cancer or cardiovascular diseases", according to Baker.
The EBC wants to put the emphasis on the economic burden of brain diseases, in particular on multiple sclerosis. Up to 2.5 million people worldwide are affected by multiple sclerosis. It's more often younger people between between 20 and 40 who are diagnosed with multiple sclerosis, and women are diagnosed three times as often as men.
In the UK alone, the direct healthcare costs of brain diseases are estimated at 37% of the overall health budget which Baker called "an enormous amount of money, simply not sustainable".
A part from the economic burden on society, a multiple sclerosis diagnosis can be devastating for the individual young adult who may be starting careers and making plans for the future. Early adulthood is also a time when young people may be pursuing higher education, making new relationships or considering starting a family.
"They are the brains of the future," Baker said.
More attention to research
The EBC advocates for more and better funding for brain research, for example a combination of public and private sector resources. The EBC is currently working with the Commission's DG Research and the Innovative Medicines Initiative (IMI) on one of Europe's largest public-private initiatives aiming at speeding up the development of better and safer medicines. The second project, IMI2, has a budget of €3.45 billion.
"The attention paid to brain diseases is still relatively low when you compare it to cancer or diabetes. In order to raise awareness on multiple sclerosis, you need to make clear what the implications of the conditions are, what the impact they have for a condition like multiple sclerosis which hits people it their 20s. It has a huge impact," Alan Thompson, chair of the International Progressive MS Alliance, told EurActiv.
"The problem with the pharmaceutical industry is that people think they are just raising the profile in order to sell more drugs, but a combined approach should be better," he said.
According to a survey conducted in 124 countries by the Atlas of MS, access to drugs (Disease-Modifying Therapies, DMTs, or Symptomatic treatments) is very limited in low or medium-income parts of the world. Only 40% in developing countries have access as opposed to 90% in high-income countries.
"Unfortunately, inequalities remain," Thompson stated.
Source: EurActiv © 1999-2014 EurActiv.com PLC (17/02/14)


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Sat, Sep 15, 07 at 9:04
|Hi I have been reading about storing geranium over the winter. I am wondering if i dig a hole in the yard put a layer of sand and then leaves around the pots and maybe a board over the top to keep out most water could the plants possibly survive?
I do not have room in my house for plants.
Any thoughts?
Follow-Up Postings:
|Well, considering most plants need some light and air, I doubt that they would. Try this link which deals with overwintering geraniums. There are four parts to these little videos; they are most helpful.
Here is a link that might be useful: Garden Gate
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Bass TabsBass Tabs v2ChordsChords v2Chords v3Chords v4Chords v5TabsTabs v2Tabs v3Ukulele
Chords are not 100% but I made them up to be and easy to remember singalong version. F#m sounds good with a bit of rhythm put into it. Sounds good with no capo. Would be great to hear your feedback. F#m Its you that I adore F#m Youll always be my whore F#m Youll be the mother to my child F#m And a child to my heart E D F#m We must never be apart E D F#m We must never be apart A E Lovely girl youre the beauty in my world D F#m Without you there arent reasons left to find F#m And Ill pull your crooked teeth F#m Youll be perfect just like me F#m Youll be a lover in my bed F#m And a gun to my head Am D F#m We must never be apart Am D F#m We must never be apart
Popular Smashing Pumpkins tabs & chords
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↑ Back to top | Tablatures and chords are parodies/interpretations of the original songs. You may use it for private study, scholarship, research or language learning purposes only


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The Solid Waste Management Department provides residential and commercial trash collection, and disposal.
We also oversee large-item disposal, recycling, graffiti removal, convenience centers, and neighborhood cleanup support.
Our other services include:
- Operating the City's landfills in compliance with State and Federal regulations
- Ensuring environmental safety at old landfills Managing and operating a recycling processing facility.
- Educating the public about recycling and responsible waste disposal.
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The Solid Waste Management Department initiated an Integrated Waste Management Plan to assist the Department in setting short-term and long-term goals for a sustainable, comprehensive solid waste program.
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Ladera Golf Course is home to the To'Hajiilee Summer Junior Golf Program,
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Fall and Spring Swim lessons are offered at West Mesa Aquatic Center and Sandia Pool. Classes are divided by age and skill level.
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Wow thanks so much for the nomination! Means a lot to me! :D
Type: Posts; User: xboxmom; Keyword(s):
Wow thanks so much for the nomination! Means a lot to me! :D
Ok here is mine
Wow thanks ladies, always an honor to be in the vote for a layout of the week. :D
Awww thanks Toni much appreciated. :D
Awww thanks for the nomination. It was such a fun page to make for my son and his girl! :D
Always an honor to be nominated! Thanks Ladies!!! :D Such amazing layouts all around!
Oh wow I totally missed this. Thanks for the nomination and congrats to the winning layout!
You gals are the best! :D
This may be lame but I haven't posted in forums in forever but I just really wanted to thank all you amazing ladies. Every time I come here there are always amazing comments on my layouts. Not sure...
Thanks for the nomination ladies, such an honor! :D
Totally missed thanking you ladies for the nomination. I was trying to get ready for a trip and then of course was out of town. Thanks so much!
Wow thanks for the nomination for LOTW such an honor to be amongst all these beautiful pieces of art! :D
So sweet of you to nominate my layout Ricki! Such an honor to be amongst the other nominees. Gorgeous layouts all around and such Amazing work from everyone.
Love your layout Marie!!! :D
Congrats Ricki! (oh and thanks Marie for saying how cute my little dude is, love your pic of your daughter as well. )
Oh how fun is this!!! I can't win either but this is one of my favorite photos.
Wow they all deserve a win! Great pages!
I guess that's better than nothing. GL with the organizing again. And I hope you can find everything again.
My kids all start on Sept. 4th. We have bought almost all the school supplies on the list. It already cost me $200 for supplies and $500 so far for new clothing/backpacks! And that was just for my...
I have been a stay at home mom for 17 years now. I never finished college either. I often times feel like working folks and people with degrees frown down upon me for being a stay at home mom. ...
Where you able to recover?
Thanks ladies...I seriously wish I had more time in the day as well. I'd love to sit through the galleries and leave Love to all the talent and beautiful works of scrapping art! But it's Tough! ...
Thanks for all the wonderful hello's and welcomes.
Trina- It's a million times better now that they aren't babies/toddlers. I just about lost my mind back then. Now with teenagers it's...
Awww Thanks Ladies. It's an amazing kit to work with!!! Loved every min of it!
I just wanted to send out a public thank you to all the love I have received this past week. I am honored to be working for Rachel (Seatrout Scraps) and it really feels good to get all the love on...


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Doing Time, Doing Vipassana
Description: A chronicle of Kiran Bedi, the dedicated inspector general of prisons in India who, in the mid-1990's introduced the ancient technique of Vipassana meditation -- quite literally the oldest form of Buddhist meditation -- into the violently corrupt Tihar Prison, India's worst and most dangerously overcrowded prison at the time. Her work proved invaluable. The results at Tihar Prison were almost unimaginably miraculous. After the ten-day course in Vipassana, which requires total silence and the willingness to go deep inside oneself, violent criminals were transformed -- emerging with tears of joy and opened hearts. Now Tihar has its own meditation center and penal institutions around the world are following its model. U.S. prisons are now beginning to realize the significant advances in rehabilitation brought about by this simple and purest form of spiritual introspection. From Seattle to Alabama to Northern California -- the groundwork laid by Kiran Bedi in India is likely to have worldwide ramifications, which could ultimately lead to the type of social progress only previously dreamed of in America.
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T.U.F.F. Puppy
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T.U.F.F. Puppy is an American animated television series created by Butch Hartman. The show's main character is a dog named Dudley Puppy, who works as a secret agent for an organization called T.U.F.F. (Turbo Undercover Fighting Force). His partner is a cat named Kitty Katswell. The show takes place in a city called Petropolis, which is populated by animal characters. Note two stories per episode.
Last Episode03x13 TUFF Break Up Aired: Jul. 26, 2014
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text: Books Featured in Views & Reviews Remember Me Like This Brett Anthony Johnston Debbie Doesn't Do It Anymore Walter Mosley One Way Out: The Inside History of the Allman Brothers Band Alan Paul The Beginning of Everything Robyn Schneider The Girl in the Road Monica Byrne Lucky Us Amy Bloom To Rise Again at a Decent Hour Joshua Ferris Capital in the 21st Century Thomas Piketty Some Luck Jane Smiley Midnight Crossroad Charlaine Harris Welcome to Midnight, Texas, a town with many boarded-up windows and few full-time inhabitants, located at the crossing of Witch Light Road and Davy Road. It's a pretty standard dried-up western town. There's a pawnshop (someone lives in the basement and is seen only at night). There's a diner (people who are just passing through tend not to linger). And there's new resident Manfred Bernardo, who thinks he's found the perfect place to work in private (and who has secrets of his own). Age of Ambition: Chasing Fortune, Truth, and Faith in the New China Evan Osnos Bird Box Josh Malerman The Arsonist Sue Miller Neverhome Laird Hunt What Is Visible Kimberly Elkins I Am Pilgrim Terry Hayes Book Sites & Reviews Views & Reviews - our online magazineBookNews from DMPLFantastic Fiction - Teen & Adult books including series orderNPR BooksNew York Times Book ReviewKirkus ReviewsOverbookedBookishLatino Stories Printer-friendly version Printer-friendly version


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A Risen Christ In Eastertime
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|Format: Paperback
Vendor: Liturgical Press
Publication Date: 1991
Dimensions: 8 1/2 X 5 1/2 (inches)
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In his other books for Advent, Christmas, and Lent published by The Liturgical Press, Father Brown has made the rich insights of modern biblical exegesis conveniently available for reflection during the great feasts of the liturgical year. Here he does the same for the Easter season by commenting on the Gospel stories of the risen Christ.
Rather than focusing on the differences between the evangelists' accounts of the resurrection, Father Brown instead concentrates on how each treatment of the resurrection fits the theology and plan of its Gospel. Those people who afford the Church's liturgical calendar a major role in their spiritual life will appreciate the added meaning Father Brown infuses into these stories that dwell at the heart of our faith.
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