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Trapidil is used in the therapy of syndromes that may be influenced by immunomodulators. Trapidil is used for the preparation of a drug for the therapy or prophylaxis of diseases associated with TNF-induced pathological disorders.
1. A method for the therapy of diseases which respond to substances with immunomodulatory activity comprising administration to a patient a drug comprising Trapidil as an immunomodulating active ingredient.
2. A method for treating diseases which are related to TNF-related pathological disturbances comprising administration of Trapidil to retard TNF-α activity along with medicine used to treat the disease.
3. The method according to claim 2 wherein the disease is associated with leukocyte-derived cytokins of the tumour necrosis factor (TNF).
4. The method of claim 2 wherein the Trapidil dosage units in drug form are between 10 mg and 500 mg.
5. The method of claim 2 wherein a compound of the interferon is administered additionally by one of, in combination with the Trapidil or by separate administration.
6. The method of claim 2 wherein an active ingredient promoting TNF production is administered in addition to the Trapidil by one of jointly or separately side by side.
7. The method of claim 2 wherein, in addition to the Trapidil, a glucocorticoid is administered in combination therewith by one of jointly or separately.
8. The method for treating diseases according to claim 2 wherein the diseases are associated with leukocyte-derived cytokins of the tumour necrosis factor (TNF).
9. The method according to claim 8 wherein the Trapidil dosage units in drug form are between 10 mg and 500 mg.
10. The method according to claim 8 wherein a compound of the interferon is applied additionally by one of, in combination with the Trapidil jointly or by separate administration.
11. The method according to claim 8 wherein an active ingredient promoting TNF production is administered in addition to the Trapidil by one of jointly or separately side by side.
12. The method according to claim 8 wherein, in addition to the Trapidil, a glucocorticoid is administered in combination therewith by one of jointly or by separate administration.
13. The method according to claim 3 wherein the Trapidil dosage units in drug form are between 10 mg and 500 mg.
14. The method according to claim 3 wherein a compound of the interferon is administered additionally by one of, in combination with the Trapidil jointly or by separate administration.
15. The method according to claim 3 wherein an active ingredient promoting TNF production is administered in addition to the Trapidil by one of jointly or separately side by side.
16. The method according to claim 3 wherein, in addition to the Trapidil, a glucocorticoid is administered in combination therewith by one of jointly or by separate administration.
17. The method according to claim 4 wherein a compound of the interferon is administered additionally by one of, in combination with the Trapidil jointly or by separate administration.
18. The method according to claim 4 wherein an active ingredient promoting TNF production is administered in addition to the Trapidil by one of jointly or separately side by side.
19. The method according to claim 4 wherein, in addition to the Trapidil, a glucocorticoid is administered in combination therewith by one of jointly or by separate administration.
This application is the U.S. national-phase application of PCT International application Ser. No. PCT/EP96/01037.
The present invention relates to the use of Trapidil (Trapymin) for preparing drugs suitable for the therapy of diseases which may be influenced favourably by the action of an immunomodulatory active ingredient. Chemically, the substance Trapidil is an N,N-diethyl-5-methyl-s-triazolo[1,5-a]-pyrimidine. Its clinical-pharmacological activity as known so far extends to the treatment of coronary cardiac diseases both in case of acute attacks as well as prophylaxis and long-term administration in case of this chronic disease. Trapidil, which acts as an anti-ischaemic agent, is not comparable with other coronary dilators and the remaining anti-angina coronary therapeutic agents of the prior art, for example the nitrates or nitro compounds such as nitroglycerine or isosorbide dinitrate, the β-receptor blockers such as propranolol or calcium antagonists (Nifedipin), either with regard to its clinical spectrum of activity or its chemical structure.
In view of its triazolo[1,5-a)-pyrimidine structure, Trapidil holds a special position among coronary therapeutic agents, because it is the only active ingredient with this particular ring structure in this series of drugs. From the group of triazolo pyrimidines, only 1,4-dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo[4,5-d]-pyrimidine-7-one has been tested experimentally as an anti-asthmatic agent; the less common 5-amino-1,6-dihydro-7H-1,2,3-triazolo[4,5-d]-pyrimidine-7-one, also known as 8-azaguanine, is known as a cytostatic drug.
Experiments on the myocardium of animals (T. Betke, H. Mehl, W. Meier, W. Schmitz et al.: "Effects of the Triazolopyrimidine Trapidil on force of contraction, beating frequency and phosphodiesterase I-IV activity of guinea pig hearts", Arzneimittelforschung 41/5, p. 461-468, 1991) have shown that Trapidil inhibits the phospodiesterases I-IV, i.e. is an unspecified inhibitor of the isoenzymes PDE I-IV. This is in contrast to the specific PDE-inhibitors in the form of methyl xanthines, for example pentoxifylline, which is a specific inhibitor of the PDE III isoenzyme. This activity stands for an antagonistic effect with a view to the adenosine receptor. In other words, adenosine receptors are not influenced by Trapidil, which was shown by the experiments conducted by E. G. Krause "Hemmung der Isoenzyme der Phosphodiesterase aus Herzmuskel, glatter Muskulatur und Thrombozyten durch Trapidil" (Inhibition of isoenzymes of phosphodiesterase from the myocardium, non-striated muscles and thrombocytes by Trapidil) (cf. Trapidil Workshop, June 28/29, 1991 in Munich).
From Circulatory Shock, 44, pages 97-103 (1995), it is also known that pentoxifyllin may have advantages in case of bacterial infections or malaria of the mouse in connection with a TNF-α-inhibiting activity. It is also generally known that pentoxifyllin, a xanthine derivative having a completely different chemical structure from Trapidil, primarily activates circulation in the peripheral vessels. Thus, the circulatory activity of Trapidil with its effect on the coronaries is completely different from the action profile of pentoxifyllin.
In view of this specific action of Trapidil on the activity of the coronaries, it was surprising to find now that this triazolopyrimidine derivative has a favourable effect on a series of syndromes which respond to a substance with immunomodulatory activities. This includes a number of syndromes that occur in connection with infections, neoplasms and patho-immunogenic diseases. In particular, we have found unexpectedly that Trapidil has a tumour necrosis factor (TNF-α)-inhibiting activity.
In general, the TNF is a cytokine such as IFN-γ, IL and CSF which are formed by different types of cells such as monocytes or macrophages. This factor has a wide spectrum of biological activities which play a role in the response of the organism, for example, to infections, neoplasms and pathoimmunogenic diseases. These include, for example, an increased proagulating activity at the endothelium, extravasation, cytokine (IL-1, IL-8, CSF) synthesis as well as PAF synthesis and an increased number of adhesion molecules. On leukocytes, the TNF causes an increase of neutrophilic degranulation, oxygen radicals, cytokine (IL-1, CSF) synthesis and influences the prostacyclin E2 formation. The TNF activity is also evident in the lung, where an increased capillary permeability, formation of oedemas as well as adhesion and activation of leukocytes are recorded.
TNF also attacks both the liver where the formation of so-called acute phase proteins is increased and the muscles, where the protein degradation is increased and the glycogen content reduced. In addition, TNF causes feverish symptoms on the central nervous system which are accompanied by increased anorexia and ACTH release. From these activities, we can draw the conclusion that the TNF plays a substantial role with regard to the resistance of the organism against foreign organisms and tumour cells.
Thanks to the TNF-inhibiting activity of Trapidil, a series of novel indications result for this active ingredient, which per se acts on the coronaries.
Thus, especially those syndromes may be influenced favourably by the administration of Trapidil which develop in connection with the TNF mediator effect in inflammatory processes, for example processes mediated by leukocyte-derived cytokines of the interleukin (IL) type.
Therefore, the administration of Trapidil is indicated in case of lung failure, multiple organ failure as a result of septic shock (ARDS/acquired respiratory distress syndrome), cachectic lung disease, pneumonitis, peritonitis, cachectic conditions in connection with the HIV syndrome and the acute phase of virus re-duplication, as well as cachectic conditions in connection with tumours, diseases of the central nervous system, for example in case of cerebral malaria (clinical outcome) or multiple sclerosis to reduce the activity of the disease or exert a favourable influence on MS episodes, in case of vascular headache (suppression of local TNF production), contact eczemas, psoriasis or neurodermitis in connection with the inhibition of local TNF genesis. Further possible indications are sclerodermia, diabetic triopathy (neuropathy, retinopathy and nephropathy), as well as keloids and morphoea. Additional diseases which may be influenced favourably by the administration of Trapidil are lymphatic oedemas, myx oedemas, sclerodermia, calcinosis cutis, Kawasaki disease, disorders caused by the deposition of immunocomplexes such as rheumatoid arthritis, systemic lupus erythematodes, periarteritis nodosa, poly- and dermatomyositis, diffuse fibrotic alveolitis, certain forms of glomerulopathy, lepra, trypanosomiasis, chronic-aggressive hepatitis and Dengue fever, as well as the Joop Buckley syndrome which is an immunodeficiency syndrome in connection with IgE hyperimmunoglobulin, and xanthomatoses or sarcoidosis.
The above-mentioned immunomodulatory activity is also connected with the interleukin-inhibiting activity which we found unexpectedly. Unless already taken into account among the above novel medical indications of Trapidil, this active ingredient has also shown a positive influence in the following syndromes: loss of appetite, damages as a result of dialysis such as dialysis arthropathy, dialysis osteopathy or other dialysis incompatibilities or damages, endotoxic shock, toxic shock syndrome, cachexia, myalgia caused by infections, osteoporosis, rheumatic arthritis, gouty arthritis as well as morbus Crohn and colitis ulcerosa.
Transplantation-related GVH reactions may also be influenced positively by Trapidil in connection with bone marrow transplantations. This also applies in case of kidney transplantations with regard to relieving OTK-3 side effects by administering this active ingredient.
However, lesions caused by physical traumas--be they of mechanical origin like lacerations, contusions or wounds, be they injuries caused by thermal action on the body tissue, for example burns or frostbite, or traumas caused by electricity--may also be treated with Trapidil. The same applies for the detrimental effects of irradiation, be they X-rays, ultraviolet rays, infrared rays or γ-rays.
By treatment with drugs containing Trapidil, all kinds of infectious diseases caused by bacteria, bacilli, fungi, viruses or parasites may also be influenced positively. In addition, symptoms caused by the detrimental effect of environmental toxins such as heavy metal, asbestos, beryllium, chromium or mercury compounds as well as intoxication caused by herbicides or pesticides may be alleviated.
Due to the above-mentioned TNF-α-inhibiting activity, Trapidil is particularly well suited for a therapy with medicaments which cause release of the tumour necrosis factor (TNF). This permits suppression of the side effects of such TNF-releasing substances, for example from the series of macrolide and polyene antibiotics which have some antimycotic activity, especially those obtained from streptomyces species such as streptomyces nodosus, streptomyces noursei or streptomyces antibioticus. In case of treatment with cyclosporine A, it is possible to reduce the nephrotoxicity by the additional administration of Trapidil.
Thus, this combination therapy permits treatment which is harmless under toxicological aspects. Trapidil itself may also be used directly with the tumour necrosis factor TNF, for example in the therapy of neoplasms, avoiding acute damage to the lung and hypotension. Trapidil administration may also be considered in case of acute kidney failure after reperfusion of the kidney.
It has also been found that Trapidil has a beneficial effect in the treatment of proliferating skin diseases, for example atopic, unspecified or allergic contact dermatitis, basal or scaly skin carcinomas, ichthyosis diseases, hyperkeratoses, pre-malignant sun-keratosis or other keratoses, acne as well as seborrhoic dermatitis.
Quite unexpectedly, neurological disorders such as morbus Parkinson or epilepsy may also be favourably influenced by the administration of Trapidil.
The individual Trapidil dosages used for therapy or prevention are between 10 mg and 500 mg; the total daily dosage is between 50 mg and 3.000 mg in case of oral administration, between 1 mg and 10 mg per kilogram bodyweight in case of intravenous administration and between 250 and 3.000 mg per individual topical application. The preferred dosages are 100 mg to 600 mg per day in case of oral or parenteral administration; 50 mg, 100 mg, 200 mg, 300 mg, 400 mg or 500 mg are especially preferred single dosages.
The same dosages in form of individual or daily doses are also recommended when combining Trapidil with other active ingredients. One of the combination variations of Trapidil is the joint or separate administration in connection with corticosteroids which are used in individual doses between 0.01 mg to 300 mg depending on the type of glucocorticoid used such as prednisolone, prednisone, hydrocortisone (cortisone), dexamethasone, cortisone, triamincolone, betamethasone, individual doses of 0.5 mg, 1 mg, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg or 500 mg are possible. The daily dosages may go as high as the double, triple or quadruple amount and may be between 1 mg and 1000 mg.
Other advantageous combinations also result from the joint or separate administration of Trapidil together with interferons, for example, α, β or γ-interferon of type I which is administered in an amount of 0.1 to 100�106 IU. A preferred individual interferon dose are 1, 3, 5, 10 or 20�106 IU per application or the double, triple or quadruple amount as daily dosage. If Trapidil is to be used to suppress TNF-induced side effects, the above individual or daily dosages are recommended, the drug causing TNF-induced damages being administered in the customary amount of, for example, 0.1 mg to 1 mg/kg bodyweight per day or as single dose of 50 mg of lyophilisate for infusion in case of a macrolide or polyene antibiotic or antimycotic agent.
In the therapy of neoplasms, Trapidil is also used in the above-mentioned daily or individual doses. In case of direct administration of the tumour necrosis factor TNF itself, the single or daily dosage of the latter active ingredient is between 0.5 and 10�106 IU per kilogram bodyweight.
The preparation of drug forms, namely both of the single substance preparations having a Trapidil content and the combination preparation containing Trapidil together with other ingredients, especially one or several of the above-mentioned drugs, is carried out in the conventional manner. In case of combination preparations, the individual single doses may be combined directly depending on their compatibility with each other or be present in separate form in one drug package. This permits their application either by single administration side by side or, in case of the separate form, one after the other. This latter possibility is particularly suited for such drug forms where the joint administration of the different active ingredients would cause chemical or pharmacological incompatibilities or where different forms of administration must be selected on the basis of specific pharmacokinetic conditions. In such cases, one active ingredient may, for example, be administered orally and the other parenterally, optionally at different times.
For peroral administration, tablets, sugar-coated tablets, sustained-release tablets, capsules, film-coated tablets, powders, chewing gum or liquid forms such as suspensions, elixirs or solutions may be used. For mucous administration, sublingual forms such as tablets, chewing gum etc. are suitable. Another form of mucous administration is the application of suppositories. Parenteral administration may take place by the intravenous or interarterial route. For this purpose, aqueous injection or infusion solutions are suitable which are prepared by means of sterile filtration. For topical-systemic application of Trapidil, transdermal drug forms such as plasters may be used.
______________________________________Composition/Ingredients mg/tablet______________________________________Trapidil 300.00Sodium alginate 150.00Lactose � 1H2 O 110.00Poly-(1-vinyl-2-pyrrolidone) 20.00Purified water 23.20Talcum 10.80______________________________________
The sodium alginate may be substituted by other hydrophilic skeleton substances such as cellulose derivatives (e.g. hydroxyethyl cellulose, hydroxypropyl cellulose, methylhydroxypropyl cellulose, polyacrylic acid and/or polyvinyl alcohol).
Depending on the requirements of the patient, the dose of the active ingredient may be varied within the framework described above. When making such variations, the amounts of excipient must be adjusted accordingly. In individual cases, however, the individual dose may be up to 700, 800, 900, 1000, 1100 or 1200 mg in the sustained-release form.
Suitable excipients for any solid or liquid drug forms are cellulose or cellulose derivatives, gelatine, starch or sugars such as lactose, sucrose, sorbitol, mannitol or water-insoluble inorganic substances such as dicalcium phosphate or calcium phosphate, glucose, rupturing agents, emulsifiers, dispersants or suspending agents as well as binders such as sodium carboxymethyl starch, carboxymethyl cellulose, calcium and other cellulose derivatives, alginic acid, polyvinyl pyrrolidones, gelatine, starch, alginates or polyethylene glycols (polywaxes) or lubricants and anti-adhesive agents. If necessary, stabilisers, colouring and aroma agents, preservatives or buffer substances are added to provide isotonicity and chemical stability. It is also possible to use various excipients in order to control a specific release rate in case of solid oral drug forms or a suitable grain size distribution of the active ingredients which result in a certain release picture.
For topical administration, ointments, creams of oil in water or water in oil and amphiphilic systems, micro-emulsions as well as gels and pastes and lotions are suitable. When preparing these drug forms intended for external administration, customary additives such as skin-compatible solvents like water, ethanol or isopropanol as well as polyhydric alcohols such as propylene glycol or glycerol are used. Suitable substances providing consistency or solubilisers are cellulose ether, long-chained fatty alcohols as well as ethoxylations products, long-chained fatty acids, hydrogenated peanut oil, semi-solid lipids such as wool wax, paraffin oil or solid or semi-solid paraffin, ester or oleic, palmitinic and/or myristic acid as well as semi-synthetic middle-chained triglycerides, polyglycols or vaseline. Among suitable emulsifiers or surfactants are compounds from the series of polyhydric alcohols partially esterified with long-chained fatty acids (of the glycerol monostearate type), polyoxyethylated derivatives of these compounds (of the Tagat� S2 type), sorbitan fatty acid esters (of the Span� or Arlacel� type) polyoxyethylated derivatives of these compounds (of the polysorbate type=Tween�), fatty acid esters of the polyoxyethylene type (Myrj� type) and fatty alcohol esters of polyoxyethylene (Brij� type).
The novel effectiveness of Trapidil shown above was found on the occasion of tests for determining the cytokine release and measuring the TNF activity. The quantitative determination of the cytokine release was carried out in a bioassay using WEHI 164 subclone 13 (fibrosarcoma lysating assay) as described by T. Espevik & J. Nissen-Meyer in: "A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumour necrosis factor from human monocytes", J. Immunol. Methods. 95 (1986), page 99 et seq. In this test, samples of pure dilutions containing the hybridoma cells are incubated for 20 hours before conducting the MTT test, as can be taken from the publication by M. B. Hanssen, S. E. Nielsen and K. Berg: Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods, 119 (1989), page 203 et seq. The cultivated plates were then measured at 540 nm in a micro ELISA measuring device (MR 580, Dynatech Laboratories, Inc. Alexandria, Va., U.S.A.). The values thus obtained on the α-TNF formed were expressed in pg/mm using an internal standard of human recombinant TNF-α (Boehringer, Mannheim, Federal Republic of Germany).
In another test, resident peritoneal mouse macrophages in a quantity of 2�105 were pre-incubated in 0.2 ml of Iscove medium with the test substances for 20 minutes. Then the cytokine formation was induced through incubation with lipopolysaccharide in an amount of 100 ng/ml from salmonella abortus equi for a period of four hours. After that, the TNF was quantitatively determined in the cytotoxicity determination process on the basis of WEHI cells. After these preparations, inhibition by Trapidil in concentrations between 1 and 10,000 μmole could be conducted systematically. Surprisingly it was found that Trapidil has a dosage-dependent inhibiting effect on TNF synthesis. It was possible to transfer this in vitro finding to clinical and in vivo conditions.
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Lacuna Coil
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Lacuna Coil, formerly known as Sleep of Right and Ethereal, is a metal band formed in Milan, Italy in 1994. The group consists of Cristina Scabbia (vocals), Andrea Ferro (vocals and keyboards), Cristiano Migliore (guitars), Marco Biazzi (guitars), Marco Coti Zelati (bass and keyboards), and Cristiano Mozzati (drums and percussion). In 1994 Andrea Ferro and Marco Coti Zelati formed Sleep of Right, but soon changed their name to Ethereal, and signed to Century Media at the end of 1997.
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City reverses Planning Commission ruling on athletic field…


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MAKING STRUFOLI(a traditional Italian sweet)
In the weeks before my father's death,
I make strufoli for him not knowing
he will enter the hospital Christmas Eve,
not knowing he will never leave that high
and narrow bed. There are piles of presents
yet to be wrapped red or green,
stacks of glossy cards to write, my work
abandoned until the new year,
and I'm at the counter, kneading dough,
heating olive oil until it spits.
A small blue flame of resentment burns.
Im in the last half of my life. The poems
I haven't written are waiting outside
the snowy window. But I'm in the kitchen,
rolling dough into fat snakes, then thin
pencils. With the sharpest knife, I cut them
into one inch bitsa slice for the prom dress
he refused to buy, the perfect one, in shell pink
satin; a chop for the college education
he didn't save for, Shes just a girl, Shell
get married, Who does she think she is? a stab
for the slap when I tried to learn Italian
from his mother, my grandmother, whose recipe
this is. The small pieces hiss in the bubbling
grease. They change into balls of gold. I drain
them on layers of paper towels. I dont know
I will never make them again, never mix
in the roasted almonds, pour warm honey
over the whole pile, sprinkle Hundreds
of Thousands, those tiny colored candies,
over the top. I only know the way my shoulders
ache, the weariness as I do the great juggle,
family, house, and work, trying to keep
all the balls in the air. And when his stubborn
breathing finally stops, when his heart gives out
at last, I only remember love as something simple
and sweet, a kiss of honey on the tongue. I take
this strufoli, that no one else will eat,
and spread it on the snow for the starlings
and the crows.
~Barbara Crooker


text:
IC Exam Updates
Oct 21, 2014 - Art of the Western World DSST added
Aug 5, 2014 - American Literature CLEP added
Test Results Ticker
December 21, 5:34pm, Member #4294979094 posted:
American Government. Passing score: 50
Scored 53 using InstantCert
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Introductory Psychology. Passing score: 50
Scored 70 using InstantCert
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text:
Francisco de Toral
|This article does not cite any references or sources. (April 2014)
Francisco (de) Toral (1502–1571) was a Franciscan missionary in New Spain, and the first Bishop of Yucatán.
As part of his effort to Christianize the Indians of New Spain, Toral learned to speak the Nahuatl and Popoloca languages, and compiled a dictionary and grammar of the latter. He also charged Bernardino de Sahagún with the creation of the Historia General de las Cosas de Nueva España. In Yucatán he led an investigation into the alleged abuses of the Maya by Diego de Landa, employing Gaspar Antonio Chi as his interpreter; Landa would eventually be acquitted, and follow Toral as Bishop of Yucatán. He claimed that crosses were being burned, and human sacrifices were made in church. In the end, Mayans were considered innocent, based on the lack of proof.
|Catholic Church titles
|Preceded by
Diego de Estremera
|Guardian of Tecamachalco[disambiguation needed]
|Succeeded by
Juan de Vesar
|Preceded by
Buenaventura de Salinas
|Guardian of Tecamachalco[disambiguation needed]
|Succeeded by
Alonso de Molina
|Preceded by
Francisco de Bustamante
|Provincial of the Province of the Holy Gospel
|Succeeded by
Francisco de Bustamante
|New diocese
|Bishop of Yucatán
|Succeeded by
Diego de Landa
|This biographical article about a Mexican religious figure is a stub. You can help Wikipedia by expanding it.
|This article related to indigenous Mesoamerican culture is a stub. You can help Wikipedia by expanding it.
|This article on a Mexican linguist is a stub. You can help Wikipedia by expanding it.


text:
OBEY Native Triangle T-Shirt
SALE $14.75 was $29.50 Item #64300JOSCNTRB
Sorry, this product is currently not available on buckle.com.
- Metallic OBEY logo graphic t-shirt
- 100% Cotton.
- Machine wash cold. Do not bleach. Tumble dry low. Do not iron if decorated.
- Made in United States.
Have a Question?
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We changed our page. Tell us what you think.
- Body length 27" on size medium.


text:
1. The Homing Instinct: Meaning and Mystery in Animal Migration
by Bernd Heinrich
A captivating exploration of the homing instinct in animals, and what it means for human happiness and survival, from the celebrated naturalist and ... More
See All Hardcovers
2. Kaufman Field Guide to Insects of North America
by Eric R Eaton, Kenn Kaufman, Rick Bowers
Many insects are difficult even for the experts to identify. In the new Kaufman Field Guide to Insects of North America, readers will find a wealth ... More
See All Softcovers
3. Parasite Rex: Inside the Bizarre World of Nature's Most Dangerous Creatures
by Carl Zimmer
Almost every animal will at some time or other become the home of a parasite. Not only are parasites the most sucessful life-forms on Earth, they ... More
See All Softcovers | Hardcovers
4. Principles of Macroeconomics
by Robert H Frank
Frank/Bernanke provides students with the core principles of macroeconomics and reinforces these principles through numerous examples. The new ... More
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5. A Field Guide to Insects: America North of Mexico
by Donald J Borror (Illustrator), Roger Tory Peterson (Editor), Richard E White
Detailed descriptions of insect orders, families, and many individual species are illustrated with 1,300 drawings and 142 superb color paintings. ... More
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6. Life Everlasting: The Animal Way of Death
by Bernd Heinrich
Bernd Heinrich receives a letter from a severely ill friend asking if he might have a "green burial" at Heinrich's hunting camp, and the acclaimed ... More
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7. Pests of the Native California Conifers
by David L Wood, MD, Thomas W Koerber, Robert F Scharpf
"This book provides an important compilation of information on major pathogens, insects, and other pests of conifers. Because conifers are of ... More
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8. Peterson First Guide to Insects
by Roger Tory Peterson (Editor), Christopher Leahy, Donald Joyce Borror
9. The Insects: An Outline of Entomology
by Professor P J Gullan
Insects represent over half of the planet's biological diversity. This popular textbook provides a comprehensive introduction to this extraordinary ... More
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10. Planet of the Bugs: Evolution and the Rise of Insects
by Scott Richard Shaw
Dinosaurs, however toothy, did not rule the earth--and neither do humans. But what were and are the true potentates of our planet? Insects, says ... More
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11. Bor Ror and DeLong's Introduction to the Study of Insects
by Norman F Johnson, Charles A Triplehorn, Donald Joyce Borror
This new edition combines the study of insects with clear and current insect identification, supplying updated information on phylogeny using ... More
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12. Keeping the Bees: Why All Bees Are at Risk and What We Can Do to Save Them
by Laurence Packer
From the jungles of South America to the deserts of Arizona, one thing remains consistent: bees are disappearing. A world without bees would be much ... More
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13. Entomology and Pest Management
by Larry P Pedigo
For undergraduate/ graduate-level introductory courses in Applied Entomology, Insect Pest Management, or Economic Entomology. Ideal for students with ... More
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14. Ant Cities
by Arthur Dorros (Illustrator)
Part of a series which is intended to encourage children to start thinking scientifically about everyday phenomenons, this book looks at the city ... More
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15. Honeybee Democracy
by Thomas D Seeley
Honeybees make decisions collectively--and democratically. Every year, faced with the life-or-death problem of choosing and traveling to a new home, ... More
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16. Savage Garden
by Leslie Nielsen
17. Bee Time: Lessons from the Hive
by Mark L Winston
Being among bees is a full-body experience, Mark Winston writes. "Bee Time" presents his reflections on three decades spent studying these remarkable ... More
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18. The Life of the Bee
by Maurice Maeterlinck
THE LIFE OF THE BEE By Iht Same Contents include: I. ON THE THRESHOLD OF THE HIVE II. THE SWARM III. THE FOUNDATION OF THE CITY IV. THE LIFE OF THE ... More
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by H÷lldobler, Wilson
View a collection of videos on Professor Wilson entitled On the Relation of Science and the Humanities This landmark work, the distillation of a ... More
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20. Beetles of Eastern North America
by Arthur V Evans
"Beetles of Eastern North America" is a landmark book--the most comprehensive full-color guide to the remarkably diverse and beautiful beetles of the ... More
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21. Caterpillars of Eastern North America: A Guide to Identification and Natural History
by David L Wagner
This lavishly illustrated guide enables explorers to identify the caterpillars of nearly 700 butterflies and moths found east of the Mississippi. The ... More
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22. Are You an Ant?
by Judy Allen
This introduction to the world of the ant aims to bring this familiar, small creature sympathetically to life. Young children should be fascinated by ... More
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23. A Sting in the Tale: My Adventures with Bumblebees
by Dave Goulson
24. Bugs in the System: Insects and Their Impact on Human Affairs
by May R Berenbaum
An entomologist's lively account of how insects impact our lives. Here is a whole world of fascinating and odd insect life, from the Roman Emperor ... More
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by Richard Alan Bradley, Steve Buchanan (Illustrator)
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text:
Holiday Closure
Office of the Registrar 2014 Holiday Schedule
Monday, December 22, 2014 – Normal Operating Hours (8:00 – 4:30)
Tuesday, December 23, 2014 – Operating Hours (8:00 – 2:00)
Wednesday, December 24, 2014 – University Holiday (Closed)
Thursday, December 25, 2014 – University Holiday (Closed)
Friday, December 26, 2014 – Closed
Monday, December 29, 2014 – Closed
Tuesday, December 30, 2014 – Closed
Wednesday, December 31, 2014 – University Holiday (Closed)
Thursday, January 1, 2015 – University Holiday (Closed)
Friday, January 2, 2015 – Closed
Fall Graduates
All schools at Emory University participate in online degree application submissions. Students may apply online to graduate through your OPUS account. Online degree applications will be available in OPUS one month prior to the deadline (see application deadlines below).
Be sure to check the degree information display carefully as you apply to ensure your diploma will be ordered correctly. If anything about your degree information does not agree with your degree intention, contact the Office of Undergraduate Education (undergraduates), or your school's Enrollment Services Office (graduates) immediately prior to applying to graduate.
Please know eligibility to apply for graduation does not necessarily mean that you have met all graduation requirements for your degree program. All requirements as stated in the Student Handbook for the year you entered the degree program supersede your eligibility to apply for graduation. You should receive additional information regarding graduation from your school.
Application Deadlines:
Fall 2014 completion: September 12, 2014
Conferral Date: December 20, 2014
Once the deadline to apply has passed, the option to apply online will no longer be available in OPUS. After the deadline, late degree applications will need to be completed using the paper form available from your school or on the Office of the Registrar's website. An application received after the deadline for the term must be accompanied by a $25.00 late application fee and submitted to your school. If a late application is accepted by the Office of the Registrar, there is no guarantee the diploma will be available at commencement.


text:
Most Recent Articles In Fashion Scoops
Latest Fashion Scoops Articles
GRAY MATTER: French clothing brand Comptoir des Cotonniers, which opened its first U.S. store in New York last October, has begun scouting for Manhattan locations for two more stores it plans to open. Marianne Romestain, the brand's general director, said the company is considering retail space on Bleecker Street and in the Meatpacking District, as well as on Columbus Avenue. Meanwhile, this week Comptoir des Cotonniers unveiled an Eighties rock chick-themed fall-winter collection at a fashion show in Paris, featuring a limited edition version of Dr. Martens' iconic boots in mousey gray.


text:
: Rumor:
Pens to go hard after Whitney
View Single Post
Mr Jiggyfly
Registered User
Join Date: Jan 2004
Posts: 15,677
vCash: 500
Originally Posted by
Whitney is just a short term fix and I am tired of this. I really want Shero to look for one long term winger for both Crosby and Malkin. We can have a Kunitz, Dupuis, or Talbot for one of their wings as long as they have a gifted winger on the other side. Shero should be going after Frolov, Zherdev, Versteeg, and even someone like Sharp who is a center to maybe play wing. If you got two guys like these players one for each of our top two lines then we would be set for years for the top 2 lines.
I say offer a deal like the Hawks did for Hossa with 4 or 5 fake years in the deal to bring down the cap number. We should make a run at Frolov with that kind of deal.
Trading for Versteeg is interesting because the Hawks are in such a bad cap situation and have no leverage. No way will they get close to fair value for any of their players they are trying to trade because all the GM's know their cap situation and are not going to help them out of it without some great deal that steals players away for half their real value. Remember Jagr and Kovy trades?
Not to pick on you, but too many people don't watch the players they "want" and it turns into posts like this.
Frolov, as I have touched on in other posts, will pull a Poni and disappear for weeks at a time. His own GM has said as much and eventhough they have plenty of cap room in LA, he doesn't want to sign him.
Think about why.
Mr Jiggyfly
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babys father gets physical
Get out! Is there some place you can go?
I would also go ahead and file a report with the police. You say he hasn't hurt you enough to get a restraining order.. yet. You don't want to wait until that point to get some documentation. Even if they can't do anything right now, if and when things go further, you'll be glad you have this documented.
Good luck and stay strong!
Girl you need to LEAVE, like now. I've been there before and the best decision I have ever made was to leave. You, nor anyone else ever deserves this type of treatment. There's no reason for you to stick around and if you have no where to go they have free shelters everywhere for women in danger to stay at. It may just be a hair pull or an arm grab now but trust me it does get worse and people like that will not change unless they get some SERIOUS counseling. Your main priorities right now are yourself and your baby and as hard as it is to hear, you need to go. I know its not what you want to hear but even you yourself said you feel threatened :/. Private message me anytime if you need someone to talk to. xoxo
Also, do some research. There is no way a judge is going to give a father full custody from a completely sane mother just because she isnt employed. Although, you really should start looking for a job because you are about to have a baby. If i sound mean, thats too bad. Im telling you how it was told to me to make me finally understand.
Like everyone else said, LEAVE but make sure you report it. He will be arrested and there will be a domestic violence case charged against him by the state. He will probably be required to go to counseling classes and be put on probation. He can threaten all he wants but the more documentation they have of an abusive situation, the less likely they will be to send that baby to the father over you. He will be required to pay child support to you for the baby whether you have a job or not as long as you have full custody and his income is greater than yours.
'05-10w mmc
'06-baby ft unplanned cs
'10-baby ft HBAC after PTL (bedrest @29w3d)
'13-5w mc; 8w mc
'14-10w mmc (T9)
PGS+IVF#1: 1 normal blast; Jan FET tbd
Yes he has. He hit you. That's enough.
Leave and get a good lawyer set up.


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31-40 of 91 properties for sale found
4 bedroom end of terrace house for sale Blythswood Road, Goodmayes, Essex
Chain Free! This is a rare opportunity to secure either a wonderful family home with instant investment income from the self-contained annexe. Coming with a corner plot and rear access via a rolling shutter, this house really has it all. Once inside the size of this house paves the way for a love... More details ›
4 bedroom house for sale Aberdour Road, Goodmayes
A chance to acquire this extended four bedroom house overlooking Goodmayes Park. Located within a close distance to Goodmayes BR and shopping amenities the property also benefits from Ground floor shower room, off street parking, full double glazing, a large double garage to rear and many more feat More details ›
£435,000 Offers in Excess of
Offers in Excess of £435,000
3 bedroom detached house for sale Broomhill Road, Goodmayes, Essex, IG3
Sandra Davidson Estate Agents are pleased to present this delightful halls adjoining semi detached property. Located in a popular location between Abbotsford Road and Green Lane. This pleasant residential turning is within comfortable walking distance of Goodmayes station and local bus routes. ... More details ›
5 bedroom terraced house for sale Dunkeld Road, Dagenham, Essex, RM8
Sandra Davidson are pleased to present this extended middle terraced family house, situated close to Goodmayes Park. Picture windows with panoramic views overlooking park to the rear. The property comprises: five bedrooms (incl loft), two receptions, extended kitchen, first floor family bathro... More details ›
£425,000 Offers Over
- Photos: 15
- Floorplans: 0
Offers Over £425,000
4 bedroom terraced house for sale KINFAUNS ROAD, Ilford, IG3
Extended & refurbished FOUR BEDROOM residence close to Goodmayes Station. Hall 2 good size reception rooms, stunning new kitchen/breakfast room, shower/clkroom, first floor bathroom, garden, parking and gas central heating. Close to shops and schools. INTERNAL VIEWING RECOMMENDED - OFFERS INVITED. More details ›
Guide Price £425,000
5 bedroom semi-detached house for sale Barley Lane, Goodmayes, Ilford
LET YOUR FAMILY GROW - GUIDE PRICE £425,000 - £450,000 A well presented five bedroom, double fronted, semi detached property. With an integral garage, good size rear garden and ample off street parking. More details ›
Guide Price £425,000
4 bedroom semi-detached house for sale ABBOTSFORD ROAD, Ilford, IG3
EXTENDED 4 BED SEMI-DETACHED in a sought after location close to Goodmayes Park and convenient for Goodmayes station. Hall, 3 RECEPTION ROOMS, kitchen, ground floor shower/wc, first floor bathroom, 80ft garden, double glazing & gas c/H. SCOPE TO IMPROVE & ENLARGE. Guide price £425,000 - £450,000 More details ›
Guide Price £425,000
4 bedroom semi-detached bungalow for sale 4 Bedroom Bungalow, Brownlea Gardens, Ilford
POTENTIAL!! This 4 bedroom 2 reception, 2 bathroom bungalow offers a brilliant opportunity to acquire a sought after property in a sought after location in the Seven Kings bungalow estate. This property is in need of some modernisation, hence the price. There is potential to extend STPP. Driveway... More details ›
4 bedroom house for sale Kinfauns Road, Ilford, IG3
Reeds Rains present this truly outstanding completely refurbished character property close to Goodmayes Station Ilford. Presented with an amazing rear kitchen extension, four bedrooms including a loft master bedroom suite, two further receptions and two washrooms. With the inclusion of fresh ele... More details ›
4 bedroom terraced house for sale Blythswood Road, ILFORD, Essex
Ellis and Co are delighted to offer you this beautiful modern large four bedroom house with first floor bathroom, and shower room ground floor, parking for up to two cars on the drive. More details ›
Thank you.
Your information has been sent to 0 out of 35 agents who have property to sell in the area you specified.


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Blogs Thailand Getting Serious About Animation
Paul Younghusband discovers the Thai's keen to make their country not just a world-class destination for tourism, but for animation too.
Paul Younghusband discovers the Thai's keen to make their country not just a world-class destination for tourism, but for animation too.
John Lasseter's short film 'Luxo Jr.,' nominated for an Academy Award in 1986 for best animated short, is added to the National Film Registry of the Library of Congress.
Custom typography featured in now-famous title sequence animated using Adobe After Effects, Autodesk Maya, The Foundry's Nuke, and Tweak RV.
Ubisoft taps Puppetworks Studios to create 13 minutes of full CG cutscenes for their new game 'The Crew.'
Visual effects software developer Boris FX signs an agreement to acquire Imagineer Systems Ltd., the UK-based developer of the exclusive Planar Tracking and masking tools.
The latest 'Jungle Book' revamp will blend live-action with CGI, and is set for an October 2015 release date.
To avoid getting caught in the wake of J.J. Abrams' 'Star Wars: The Force Awakens,' DWA and partner Fox move the animated threequel from December 23, 2015, to March 18, 2016.
The Foundry appoints Montreal-based business development company SDLC worldwide partner for its web-based collaborative tool FLIX.
Improved render speeds, new Microfacet GTR / GGX BRDF, and major advancements in GPU rendering now available.
The nominees for Best Animated Feature Film are Disney's 'Big Hero 6,' Reel FX's 'The Book Of Life,' LAIKA's 'The Boxtrolls,' DreamWorks Animation's 'How To Train Your Dragon 2' and Warner Bros.' 'The LEGO Movie.'
Massive data breach in November reveals that the studio is developing an animated 'Spider-Man' comedy feature to be directed by 'The LEGO Movie's Phil Lord and Chris Miller.
The legendary animator discusses Disney legends, creativity versus technology, and his latest interactive hand-drawn short film for Google ATAP.
Pixar unveils a new look at the little voices inside our heads with the first full trailer for its upcoming animated feature, 'Inside Out.'
Kansas City-based 3D animation/VFX boutique restructures and expands its reach to include projection mapping, digital media and mobile applications.
Open API and in-depth render farm support ensure 7,000 cores process efficiently during work on 3d animated feature.
'Kung Fu Panda' director Mark Osborne helms the CG/stop-motion hybrid film adaptation, due to be released in France on October 7, 2015.
The follow-up to 2003's Oscar-winning 'Finding Nemo' is to be set in the fictional Marine Biology Institute of California.
Framestore dishes out Christmas cuteness with the "cutest ad ever," including puppies, kittens, piglets, and a gloriously incongruous CG Narwhal.
Five-title animation package of more than 80 hours of children's content destined for Thailand, Laos and Myanmar.


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The Lord's Servant
When interacting with others, Christian leaders – and the rest of us – may be tempted to quarrel over points where we disagree. Exploring the final verses of 2 Timothy 2, Alistair Begg shows how the Apostle Paul emphasized kindness and patience toward all people, allowing God Himself to stir repentance in unbelieving hearts.
sku: 3047CD
A Consecrated Life
When we consider what it might look like to live a life that is committed to the cause of the Gospel, the Apostle Paul is an excellent example.
As Alistair Begg explains, what set Paul apart was not that he didn't value the ordinary experiences of life, but that he viewed them all in relationship to the purposes and care of God. When we live with the Gospel in view, we learn that the greatest value is in a life lived well for God's glory.
sku: 3046CD
Pastor and People
What does a healthy church look like? In 2 Timothy 2:14-19, we learn that one distinguishing mark is a pastor committed to the Word of God. As Alistair Begg explains, pastors must ground their ministry in the Gospel while the people resist the temptation to quarrel over nonessentials. When this happens, God works through His Word, by His Spirit, in His people, and churches grow in maturity and godliness.
sku: 3043CD
An Unashamed Worker
Pastors face constant pressure to swerve from the clear truths of the Gospel and to pursue the approval of others. Alistair Begg encourages pastors to steer a different course for ministry by living and serving for the approval of God. Although discouragements may abound, pastors and their congregations can be encouraged that God is working out His good purposes as we strive for purity in doctrine and lifestyle.
sku: 3044CD
Discipleship in 3-D, Part Two
Farmers reap a harvest through patient attention to the daily demands of their crops and consistent hard work. Like the farmer, most of our Christian experience consists in diligent attention to the ordinary routines of life. In this message from 2 Timothy 2:4-6, Alistair Begg explores this comparison. Although the prospect can seem daunting, we can be encouraged that our obedience to the law of God in the daily routines of life and ministry flows from communion with the Lord Jesus and is enabled by the grace of God.
sku: 3035CD
Ecclesiastes Speaks Today, Part One
How does one do Gospel ministry in a culture that is undergoing a serious moral crisis? In the opening session of the 2014 Basics Conference, Alistair Begg answers this question with a surprising reply: preach through Ecclesiastes! With a message as equally relevant and timely today as it was then, Ecclesiastes demands a fresh look.
sku: 3032CD
Series: Basics 2014
Seven Vital Truths About a Culture of Prayer
The early Church clearly understood that prayer is at the center of Gospel ministry. Today, however, many churches have lost conviction regarding our urgent need to keep prayer at the heart of our mission. Daniel Henderson explains that praying churches are not primarily a matter of programming, but of a culture of prayer that begins with leaders who seek God earnestly and grows as prayer becomes the center of every aspect of ministry.
sku: GS1120CD
Series: Basics 2014
How to Maintain Pastoral Zeal while Avoiding Pastoral Burnout
How can burnout be a problem in ministry when Christ Himself encouraged His followers to give up everything for the sake of the Gospel? Christopher Ash explains that there is a vital difference between living sacrificially for Jesus and pursuing our calling in a way that leads to mental and physical exhaustion. When Christian leaders bear in mind that we are created by God from dust and that all of our endeavors are dependent on Him for success, we are reminded that Gospel ministry is a humbling privilege and enabled to rejoice that we are recipients of God's grace in ...
sku: GS1121CD
Series: Basics 2014
The God Who Speaks
In 1 Kings 19, we see the postscript to Elijah's famous confrontation with the prophets of Baal. Gary Millar, through Elijah, helpfully shows us that God does care about his depressed, weak and confused servants, reminding us of our daily need to be sustained by a covenant-keeping God.
sku: GS1118CD
Series: Basics 2014
Panel Question Time
Listen in as Pastors Ash, Begg, and Millar answer questions from this year's Basics attendees ranging from practical advice to pastors facing burnout to addressing hot button cultural issues with clarity and sensitivity.
sku: GS1119CD
Series: Basics 2014


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Loading ...
Signature service: Combines tutoring with childcare and fun
Established: 2006
Reservations/Appointments: Required
Staff Size: 11?25 people
Average Duration of Services: 2?4 hours
Ballroom, Latin, Swing and Fitness for all ages! Dancing made fun AND easy! We can teach ANYONE!
No contracts or membership fees!
No partner or experience required.
We work with people with two left feet so they feel confident on the dance floor, and with top level competitors to give them that extra edge.
The Center has welcomed kids onto its farm since 1936. It probably wasn't as much of a novelty back then, when Illinois was home to more than 220,000 farms and the U.S. government issued everyone a farmer's hat at birth. But that number has decreased steadily with each decade, dropping to just 76,000 by 2010, per the USDA. Which means that today, The Children's Farm at The Center gives kids and their families something increasingly special: the chance to experience life on an independent rural farm. Here, chickens lay eggs, goats give milk, and horses eat hay harvested right on the farm. The staff also leads tours of these grounds and explains how each animal fits into farm life. They even let kids pet some of the livestock before finishing up tours with a hayride.
For a completely immersive experience, The Children's Farm hosts summer camps for ages 3–17. During each camp session, campers live on the farm for days or weeks at a time, spending their days riding horses and caring for the animals.
Toy Box Connection aims to help all children receive the gift of a toy or a book year-round, serving as the connection between the families and businesses that donate these items and the children who need them. After accepting new and gently used toys, Toy Box Connection sorts and cleans them at its warehouse, then redistributes the toys and books to its partner nonprofit organizations. From there, the items are given directly to the children in need. Special projects include donating toys to children in the hospital, families of returning troops, and children in special needs or foster camps.
Growing Power provides the means for communities to grow and distribute healthy food among their own residents through three important functions: growing demonstrations, education, and food production. Demonstrations come in the form of workshops designed to teach locals of the Midwest, the South, and New England how to grow fresh produce. On the education side, outreach programs for farmers, youth, and entire communities help spread awareness about the importance of community agriculture. Finally, the organization produces food in demonstration greenhouses and rural and urban farms in the Midwest. It distributes the produce and grass-fed meat it produces through 300 family farms as part of the Rainbow Farmers Cooperative, and to local families through the Farm-to-City Market Basket Program. This way, the people the organization benefits can have access to nutritious food regardless of location, income, or scarecrow phobias.
A debilitating illness that affects more than 400,000 people across the country, multiple sclerosis is a formidable opponent for even the strongest people. Fortunately, the do-gooders behind the National Multiple Sclerosis Society pair their fighting spirit and dedication to scientific breakthroughs with something even more powerful: bushels and bushels of cash. In every state, its members volunteer their time to advocate, educate, and raise money to find a cure. One of the larger chapters is the Greater Illinois Chapter, which spans 73 Illinois counties. The chapter?s signature event is the annual MS Soir?e, a cocktail party and casino night featuring glittering gowns and enticing live music. While the event?s venue changes from time to time, past bashes have taken place at plush downtown hotels such as theWit, Swiss?tel, and the Hard Rock Hotel.


text:
Aspens is part of the Stansted Lodge group. Aspens is approximately 7 minutes from Stansted Airport.Airport Transfers at 6 pounds per person per trip includes children and infants.Stansted Lodge provides airport transfers subject to availability. Although every effort will be made to provide this service, Stansted Lodge reserves the right to cancel any arranged transfers or not to provide transfers.
Airport transfers are provided strictly from 4:00 am to 10:00 (10am) and 16:00 (4pm) till 21:50
Transfer Costs:
Our evening transfers start at 4pm and finish at 10pm, last pick-up from the airport is 21:50. If you arrive within our transfer times, please, before ringing us go to the Orange Car park Row 'A' . The fee will be 6.00 pounds per person per trip includes children and infants. If you arrive after 21:50 you will need to get a taxi at a cost of around 15.00. When you arrive, just ring the door bell once and give us time to get to the door before you ring a second time.
Our morning transfers start at 4am and finish at 10am.
Guests need to follow these rules when utilising our transfers from the airport. Guests will only be picked up on the hour once it has been ascertained that they are at, or have been to and seen the pick up point. This is because we only have limited time inside the car park. Once you have arrived at the meeting point, call us. The pick up point is: ORANGE Car Park Row A
Guests should contact us or arrive by 18:00 on the day of their reservation in order to guarantee room.
Aspens is located in the lovely village of Elsenham approximately 7 minutes drive from Stansted Airport. We are about 1 mile due north as the crow flies.
We pride ourselves on providing clean, secure and warm rooms, with an even warmer, friendly service.
Early check in and late check out service is available for an additional charge of 10.00, pounds subject to availability, which we will only know on the day, so you will need to check the morning of your arrival.
We offer a continental style breakfast (self service) from 03:45 till 09:00 with tea, coffee, fruit juice, jams, marmalades, cheese and a selection of cereals with milk. We provide Gluten free breakfast on request.
Our guest-house is close to a great village pub (The Crown) who provide a fantastic menu from locally sourced produce at reasonable prices.
All rooms have a television, tea and coffee facilities and an alarm clock (towels supplied). Hair dryer, iron and ironing board are also available on request.
We are not on any flight paths, so no planes overhead.
Opening hours from 16:00, vacate by 10:00.
Last Check-in 23:00 - if arriving after 18:00 you must contact us in order to hold you reservation.
Guests who stay with us are allowed to leave cars at owner's risk. We will charge £5 per day.
Laundry facilities available.
Child bed or baby cot available.
Wireless internet access available (Free of Charge).
We are close to Elsenham train station (walking distance) which gives direct access to London Liverpool Street or Cambridge.
Please write your arrival time when booking online. If you arrival time changes and you will be delayed, please give us a call.
We operate a NO SMOKING policy in all rooms.
예약 가능 여부 및 가격예약 가능 여부와 가격을 보려면 날짜를 선택한 후 '날짜 업데이트'를 클릭하세요'
- 조식 포함
- 천정 환풍기
- 예약 가능한 아기침대
- 무료 인터넷 액세스
- 무료 와이파이
- 헤어드라이기
- 인터넷 액세스
- 금연
- 차/커피 설비
- 타월 포함
취소 정책이 숙소는 1일 취소 정책이 있습니다. 이 시간 내에 취소하지 않으면 체류 첫날 밤에 부과되는 숙박료와 똑같은 금액의 취소 수수료가 발생합니다.
약도지도 보기지도 숨기기
Directions to Aspens from the M11:
1. Exit the M11 at Junction 8A.
2. Follow the signs to Stansted Airport Terminal.
3. When you reach Coopers End roundabout (the last roundabout before the Terminal) you need to take the 4th exit on the left (sign posted Mole Hill Green, Broxted and Elsenham).
4. Immediately, you will come up to a mini roundabout, turn left towards Elsenham (n.b. if you turn right you will be heading towards Takely).
5. Continue along for about 2 miles. You will pass Mole Hill Green, the Three Horse Shoes Pub and Elsenham Golf Course.
6. At the end of this road, you will then come to a T- intersection. Directly opposite is the Crown Pub.
7. Turn left at the T- intersection. This takes you onto the High St (B1051).
8. Turn right into Park Road, go towards the end, pass Coriander Drive (on the left), Aspens is about the fourth house from the end of the road on your right hand side as you face the end of the road.


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In the Data Grid environment, the primary goal of data replication is to shorten the data access time experienced by the job. Nowadays, scientific research and commercial application generate large amount of data that are required by users around the world. Data access time depends on bandwidth and storage space in each site. The major bottleneck to supporting fast data access in Grids is the high latencies of Wide Area Networks and Internet. We proved that, on the one hand high bandwidth and storage space make the enhancement of scheduling efficiency in data grids and on the other hand scheduling and data replication strategies with the high bandwidth and high storage space equally treat and have the same results. In this paper, we studied LFU, LRU, BHR and HRS algorithms and evaluated them through simulation by Gridsim.
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Hot answers tagged drag-and-drop
Drag a desktop icon a bit. Helps against the stuck launcher bar with Opera on a 32-bit system. Another solution would be to set the launcher not to hide in the first place (that's my solution for now). See How can I configure Unity's launcher auto-hide behavior? There are also bug reports: Opera: bug 741731 (note the "Won't Fix" as it's a bug in ...
Run this in a Terminal (Ctrl+Alt+T): unity --replace That works for me on Ubuntu 12.04.
While you're dragging hold your mouse over the taskbar icon of the nautilus window, and it'll be raised to the top so you can drop your files in it.
Drag-and-drop works brilliantly in Unity (in 11.04). You can drag and drop both directly onto open windows, or onto the applications launcher. In the screenshot below I'm drag-n-dropping a video file. The launcher fades the icons of all the programs that can't handle a video file, leaving only Banshee and Totem. Note that in this example then Totem is ...
The way I found it working: Start dragging, Keeping your mouse button pressed, press Super + (0-9) to switch the application, Continue dragging and drop. Note: In step 2 you can hold the Super key for a moment, the launcher will appear and will display you which number (0-9) is assigned to which application.
I haven't found a reliable way to drop file-manager files onto (for example) Totem whilst the receiving application is full-screen - however if you dont make the receiving application full-screen, the following works for me. Run CCSM and edit the Scale Addon. Click "Initiate Window Picker" (initiate edge i.e. the one with the monitor icon) and assign ...
You can get a similar result (where by "similar" I interpret "gives you a way to drag things into the Ubuntu One folder from Nautilus) in one of four ways: add an extra pane (press F3, or View → Extra Pane), switch to having a tree in the sidebar (View → Sidebar → Tree), add an extra tab (Ctrl+T, or File → New Tab), or simply open a new nautilus ...
There is a user on launchpad that found a great workaround. Use the scale plugin assigning it to one of the screen corners, it works great I would say: https://bugs.launchpad.net/unity/+bug/995039/comments/5
Locate the .desktop of app you wish to adjust, in the case meld & open in a text editor. Usually there will be a line, MimeType=, just add to it the appropriate type, if you don't know then a right click > Properties > Type will show. So in this case, 'Meld', you'd add this to the end of the MimeType= line text/x-python;inode/directory; If for some ...
Its not uncommon for the launcher to get stuck. Opening the dash with the Super Key seems to fix it for me and its way better than killing a program. If you can reproduce it, you might want to post a bug report.
Drag and Drop works only for Linux guests (guest: OS on the virtual machine) Source: Added experimental support for Drag'n'drop from the host to Linux guests. Support for more guests and for guest-to-host is planned. https://www.virtualbox.org/wiki/Changelog As guitar42697 said, you have to set a shared folder.
Responsible for this behaviour on all windows is Metacity. By opening gconf-editor we can disable it. Note that you then will no longer be able to raise any window by clicking on it.
Right-click on the Terminal title-bar and select Always On Top. You can now drag files from Nautilus to Terminal.
You need a .desktop file with EXEC= entry. See related feature request on launchpad and bugzilla.
The following script will act according to your desciption. I believe this is not the best approach for this situation, but there is not an applet with the functionality described by you that I know of. Create a file in your home folder with the following content: #!/bin/sh ubuntuone_loc="/home/user/Ubuntu One/" if [ $# -eq 0 ] ; then nautilus ...
try with: Start dragging the file Press and hold Super (windows key) + Tab (do not release the mouse button) Hold Super and press Tab as many time you need to choose your file window destination Release Super when you have selected the correct window Release mouse button to drop the file
You can't drag/drop arbitrary clipboard contents onto launchers. The MimeType entry in the .desktop file specifies what file and content types the application can open, for the MIME system, and is as I understand the code, not used by the drag and drop handling. However, rather, the content of the drop is simply passed as an argument to the program, and must ...
Since the update of Nautilus to version 3.4.2-0ubuntu3 it is now possible to simply drag and drop files and folders into Nautilus bookmarks. This is now possible due to the following bug being fixed: https://bugs.launchpad.net/ubuntu/+source/nautilus/+bug/874386
This solution woks for me Go to: http://tombuntu.com/index.php/2011/10/31/fix-for-touchpad-trouble-in-ubuntu-11-10/ From the post: One of the issues introduced by Ubuntu 11.10 on my Eee PC 901 is touchpad dragging. The tap-and-drag gesture, for moving the cursor with the mouse button depressed, is too sensitive. I have to tap as fast I can to activate the ...
It doesn't look like it. You can drag into the terminal, but apparently you can't drag from the terminal. Perhaps you already knew that though. What you should know, is that selecting copies into a separate buffer, that middle clicking pastes from. That'll be a bit faster anyway, and it works with gnome-terminal.
The only way to move a window from a workspace to the other one is launching to Activities Overview, and dragging the window to the list of workspaces on the right side of Activities Overview. You can use screen edges for desktop switching with an extension. Here it is : https://extensions.gnome.org/extension/136/desktop-scroller When you scroll at the ...
You need to be running compiz to drag windows across your virtual desktops. Metacity doesn't have this behaviour (by default anyway), although you can change what workspace a window is on by right clicking the title bar. To enable compiz: Go to System -> Administration -> Hardware Drivers and make sure you have graphics drivers (if available) installed ...
Same problem when using Netbeans (Java) : when I drag tabs to reorganize them, the launcher appears and gets stuck (ie wont hide anymore). Could not fix the problem, but found 2 solutions : - drag and drop Firefox tabs around - drag something to the laucher
I had the same problem after I moved icons around and opened the dash with the super key. I simply logged out then logged back it. Fixed it right up.
In system settings under launcher and menus you can select "Show the launcher when the pointer touches the top left of the screen" This will now mean you will not see the launcher until you move the mouse pointer to the top left. I hope this helps
It's in Settings -> Mouse and Touchpad. From there you can set Drag and Drop Threshold. I've got mine set pretty high for that reason.
Make sure that you have both Firefox windows open side by side, and click on the Tab that you want moved, and drag it to the new windows. or Click on the little icon to the left of a URL, and drag it to the new window. or Right click on the Tab that you want moved, and click on Move to a New Window.
I don't have an answer, but I can confirm this bug. There are other applications, where drag and drop no longer works once blender was started (Clementing, Kmail). I suppose blender does something it shouldn't do, but the other applications are at fault too. They should not get that easily confused by a misbehaving program. The only workaround I know is to ...
We are able to run Nautilus with root privileges with sudo -i nautilus but we need to be extra careful with what we do then. Root is powerful and most measures to protect our system from accidents will not work any more. Nobody will stop Root from doing stupid things. There will be no warnings. So here is my advice to people who need to run Nautilus ...
Install Synaptiks from Software Center. Synaptiks is an application for editing touch-pad settings. I think it has an option for solving your problem. Beware of size of this package.
Only top voted, non community-wiki answers of a minimum length are eligible


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10 Steps to Pick the Right Doctor
Whether you need a primary care doctor or a specialist, these 10 steps will ensure you find the right doctor for you. View Slideshow
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Farsightedness Center - Yakima, WA
Yakima Ophthalmologist Doctors for Farsightedness
Type of Physician: Ophthalmologist
What is a Ophthalmologist?
A certification by the Board of Ophthalmology. Practitioners provide comprehensive eye and vision care. They are trained to diagnose, monitor, and medically or surgically treat all eyelid and orbital problems affecting the eye and visual pathways and to diagnose, monitor and treat all eye and visual disorders. They often prescribe vision services (glasses and contact lenses) as well as serve as a consultant to doctors and other professionals.
Specialty: Ophthalmology
Common Name: Eye Doctor
Ophthalmologist Doctors in Yakima *
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Michael A Warner MD
Retina Laser Eye Center
Retina & Macula Specialists
Retina & Macula Specialists
Retina & Macula Specialists
Eli Kaczynski MD
Kennewick Eye Clinic Inc
Yakima, Washington
About 1 in 4 people in the U.S. have hyperopia or farsightedness, but fortunately there are more ways to correct this eye disorder than ever before.
People with hyperopia or farsightedness have difficulty focusin...
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Emergency Contact for Yakima
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Yakima Regional Medical Center
Yakima Valley Memorial Hospital
Kittitas Valley Community Hosp
Toppenish Community Hospital
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*Provider Directory Terms of Use:
The WebMD 'Provider Directory' is provided by WebMD for use by the general public as a quick reference of information about Providers. The Provider Directory is not intended as a tool for verifying the credentials, qualifications, or abilities of any Provider contained therein. Inclusion in the Provider Directory does not imply recommendation or endorsement nor does omission in the Provider Directory imply WebMD disapproval.


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If you're a current or former client, share your thoughts (anonymously, if you prefer). Would you recommend this lawyer to other clients?Review this lawyer
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Cazenovia On Wednesday, Aug. 17, both the Cazenovia Village and Town Boards called special meetings to discuss construction on Emory Avenue.
A resolution, titled "Intermunicipal Agreement and Temporary License for Parkland Maintenance and Improvements between the Town of Cazenovia and the Village of Cazenovia" was passed by both boards, allowing a 150-foot long, 3-foot wide portion of the green opposite the high school to be paved as part of the construction project.
"A big part of this plan, aside from repairing Emory Avenue, has been to enhance and protect the green," said Village of Cazenovia Mayor Kurt Wheeler. "We need more space to make the road safer for students and safer for drivers. As it stands, it is just too tight."
As construction began on Emory Avenue in late July, engineers had planned to make the roadway wide enough for three lanes. Last week, as the project neared completion, Wheeler said Cazenovia Central School District Transportation Supervisor Karen Cowherd observed that the street looked too narrow.
The project's plans called for three, one-way car lanes on the western most portion of Emory Avenue.
The northern side of the street, closest to the high school, will be pickup/drop-off lane for students and parents, the southern side of the street would include about eight all-day parking spots and the center lane would be designated for thru traffic.
After parking three village-owned trucks side by side on the street, officials noted it was just barely wide enough for three lanes.
Wheeler and the village board then approached the town councilors to request usage of the 450-square-foot strip of the historic green.
During the town board meeting Councilor Zupan argued against the request, and asked the town board to carefully consider the agreement. "This is town property on the historic register and we have a duty to protect it. I think we should stop to really consider the situation and all possible alternatives before making any decisions," he said.
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Category Archives: News
Rock Talk November 2014
Rock Talk October 2014
Game On Toronto – Please vote!
Hello East York Curling Club Members and Friends Of Curling Everywhere,
My name is Glenn Gabriel and I am the Little Rocks Rep at East York Curling Club. Recently, I submitted an application on behalf of our Club to the Game On Toronto! grant fund.
Now we need your help!
Please visit the Game On Toronto! Web site and VOTE FOR OUR PROJECT. You'll get to see the video we produced and details of the grant project, called "Stone's Throw".
In a nutshell: In 2015, we want to introduce curling to young people from 7-11 years old who belong to populations underrepresented in our sport, namely visible minorities, new immigrants and special needs / disabled youth. Another population we want to target is the Taylor-Massey neighbourhood, which is adjacent to our Club and is a City of Toronto Neighbourhood Improvement Area.
How to vote for us…
- Visit the Game On Toronto! Website and find our video – we've done the hard part for you, just click on this link: http://bit.ly/1CX4XdH.
- Read the project description and watch the video!
- Click on the "Vote" button on the upper right.
- You can either "login" with your Facebook account OR create a login account.
- Once you login, you should be able to click on the Vote button. It will say thank you for voting once you're done.
Tell your friends to vote for us too! Forward this email, post a Facebook update or send a tweet. Every vote counts!
Remember: You can vote ONCE A DAY during the two-week voting period, which ends on November 5th.
A combination of online votes and a panel of judges reviewing our application will determine who receives grants. The results should be announced in January 2015.
Please support your Club and vote now!
Coach Glenn Gabriel
East York Little Rocks Rep 2014-2015
PS: Thanks to our awesome Little Rocks (James, Angelina, Molly, Nate, Marek, Evan D and Dexter) for appearing in the video!
Congratulations to the Men's Israeli Curling team!
The team went 1-3 in their first games, but then went on to win their 5 remaining games to qualify for the 3-4 game in the playoffs. In the playoffs they defeated Slovakia 7-6 in a tightly contested game, scoring 2 in the 10th end for the victory. The silver medal game saw them defeat Ireland 7-3 in a game which saw Israel steal or blank the first 6 ends for a 4-0 lead.
Having earned a top 2 finish, this team, along with Belgium, the gold medal winners, will play in the European Curling Championships B-Group in Champery, Switzerland November 22nd to 29th. The teams in that event include: France, Finland, Hungary, Netherlands, Estonia, Poland, Wales, England, Turkey, Austria, Spain, Croatia, Lithuania and Romania.
Good luck Yuval and team!
European Curling Group C Championship results Preview of the team on Yahoo! Sports:Israeli curling team takes first competitive steps, lofty goals in mind
Curling is around the corner!
Our ice crew has been hard at work, and curling is around the corner. Here is a small timeline on the ice:
September 30 – ring paint in progress
Bantam/Junior Trial Curling Day
Ever considered curling but not really sure what it's all about?
This is your chance to try it out!!
Come and learn the game, make some friends and have some fun!
Our experienced coaches will teach you what you need to know.
Age Range: 12-16 for Bantam curlers 17-21 for Junior curlers
Cost: $5.00
Where: East York Curling Club, 901 Cosburn Ave.
Equipment will be provided.
To Register or Have Questions? Contact: Donna Bantis, President of the Jr. Program at bantam-junior @ eastyorkcurling.ca
Spaces are limited
Our regular season runs from October 2014 to April 2015. If you interested in joining the league please visit
The Bulldog Men's Cashspiel – Accepting Entries
Over $4000 in cash and prizes – guaranteed top prize of $1000
Door prizes, eye-openers, lunch & dinner included
Three 8-end games – the perfect tune up prior to playdowns
The best value in town – just $288/team
See here for more details and entry form.
Registration now closed for Little Rocks
Thanks to everyone who signed up for the Little Rocks program at East York Curling Club this season.
We currently have 40 kids registered for the program, so, at this point, we are now closed to new registrations. We will keep a waiting list for those still interested, in the event that spots open up in our program.
We are looking forward to an exciting season that includes learning new skills, making new friends, playing games at our club and outside our club and, of course, FUN!
If you have questions, please feel free to contact me at the e-mail address below.
Coach Glenn Gabriel
2014-2015 EYCC Little Rocks Rep
littlerocks @ eastyorkcurling.ca
Open House & Registrations
The Open House will be held on September 10th at 7:00pm.
We look forward to seeing you.
Certain leagues fill up quickly, so don't wait too long register!
Online registration is now available. Please note, that this year does not yet have a payment gateway, so after completing your online registration, you will need to print and mail with payment details to consider your registration complete.
Returning member deadline: August 27, 2014!


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January 17, 2013 01:14 AM
Mercyhurst University students, from left: Erin Nee, 21; Kiersten Jungling, 20; and Alexis Pringle, 19, sample different versions of taco dip Jan. 16 at the annual "Taste or Waist" food fair, held in the Carolyn Herrmann Student Union at Mercyhurst University in Erie. About 35 students in the Nutrition for Health Professionals course prepared two versions of about 20 different dishes. The students and public were invited to sample each version and complete a survey with their guess as to which were made with lower-fat and lower-calorie ingredients. For the past eight years, Tim Harvey, assistant professor for sports medicine, has organized the event. He said many testers liked the healthier choices better, which is the result Harvey hoped his students would see. "It further solidifies (the students') understanding of the theories (they're learning)," said Harvey. CHRISTOPHER MILLETTE/ERIE TIMES-NEWS
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