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Fugitive lip biter arrested in California
Nov 6, 2014
Jonathan E. Benedict
Oct 30, 2014
Darrell W. Cook
Oct 2, 2014
Michael Polchies
Sep 25, 2014
Home » News » Crime
'Jack the Snipper' suspect arrested on exposure charge in Dover
Police said Jeffrey Gelinas, 37, on Sunday exposed his genitals to a young girl while at the Bed, Bath and Beyond store at 875 Central Ave. The girl got her mother's attention and Gelinas ran away, police said.
Police, after receiving several tips identifying him from surveillance videos, arrested him without incident on Elm Street in Manchester Tuesday.
He is scheduled to be arraigned at 10:45 a.m. today in Dover District Court.
Gelinas was paroled last year after serving an eight-year sentence.
In 2003 and 2004, Durham police had zeroed in on Gelinas as their sole suspect in eight "Jack the Snipper" burglaries. Gelinas was arrested and subsequently pleaded guilty to a single charge of attempted burglary.
"The reality of it was this was a series of acts that, I wouldn't want to say paralyzed the community, but was incredibly unsettling for the community," Durham Police Chief David L. Kurz said last year.
The case drew national media attention. At one point, Durham police consulted with a psychologist, who feared the crimes could progress into violence, Kurz said.
The Snipper never targeted university-owned housing, the chief said. He accessed off-campus apartments by walking down common hallways and checking doors. He never broke a lock or window; he merely walked into unlocked apartments, Kurz said last year.
"There were some really traumatized victims. Trauma and fear were really permeating the community," he said.
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Police investigating death of 3-year-old girl in NashuaREADER COMMENTS: 4
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Franklin man and woman arraigned for attempted prostitution of minorREADER COMMENTS: 0
Manchester school exec contract squeaks by
Pipes and plans: A chance to show up Mass.
Your Turn, NH -- Mike Moffett: Republicans can win in 2016 with Kasich at the top of the ticket
On being American: A point for reflection
- Whom do you think bears the brunt of the blame for the mayhem this weekend in Keene?
- KSC students
- 37%
- KSC administration
- 2%
- Police
- 6%
- Visitors from out of town
- 18%
- A combination of any/all of the above
- 37%
- Total Votes: 2483


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"That's What Friends Are For," Dionne Warwick & Friends
Dionne Warwick, Gladys Knight, Elton John and Stevie Wonder covered Rod Stewart for this 1985 ballad, released as a benefit for the American Foundation for AIDS Research. It raised over $3 million and topped the Billboard Hot 100 for four straight weeks.
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subset: commoncrawl


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Chris Christie's 'Black' Voters
November 5th, 2013
In less than forty-eight hours, Republican New Jersey Governor Chris Christie will be winning re-election for a second term as [&hellip
November 5th, 2013
In less than forty-eight hours, Republican New Jersey Governor Chris Christie will be winning re-election for a second term as [&hellip
November 4th, 2013
A few takeaways from Bill de Blasio's apparent victory in New York's Democratic mayoral primary: (1) If the New York Times' [&hellip
November 2nd, 2013
The GOP is gaining virtually nothing from the botched roll out of the Affordable Care Act's enrollment website. The Democrats' [&hellip
November 2nd, 2013
Rather than gloat over the Republicans getting their clocks cleaned in the government shutdown fiasco, it's worth Blacks taking time [&hellip
October 28th, 2013
What is a Republican? In this confused climate, it may be impossible to understand what a Republican is without looking [&hellip
October 26th, 2013
There was every reason to think that Jeff Greenfield's alternative history of John F. Kennedy surviving Dallas would be one [&hellip
October 22nd, 2013
Most Hollywood screenwriters have arduous stories to tell of how they wrote and then got their films made. However, not [&hellip
October 22nd, 2013
Two weeks ago, I was sent a video of a Hispanic woman interrupting a speech by Jeff Stratton, president of [&hellip
October 22nd, 2013
A good, solid shellacking opens a window of opportunity for reflection. Here are a few things Republicans should perhaps be [&hellip
October 18th, 2013
In one rosy scenario, the self destructive streak of Ted Cruz and House Republicans burns out without a default, with [&hellip
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Heston Blumenthal becomes Britain's best chef
Related galleries
Britain's Heston Blumenthal reaches no. 7 in best restaurants as Spain takes the crown
Heston Blumenthal – famous for using science to whip up unusual culinary delights – has made his way into the top ten in the list of the 50 best...
Heston Blumenthal's Dinner named no. 5 in best restaurants in the world
Heston Blumenthal's Dinner has been named the fifth best restaurant in the world, moving up two notches since last year.The good news comes for the...
Heston Blumenthal to take Fat Duck Down Under
Heston Blumenthal is jetting his Michelin-starred restaurant The Fat Duck all the way to Australia.The three Michelin-starred restaurant in Bray,...
Heston Blumenthal becomes Britain's best chef
Photo: © Getty Images


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Are you R Demlová?Claim your profile
Publications (20)25.63 Total impact
Article: Augmenting Clinical Interpretability of Thiopurine Methyltransferase Laboratory Evaluation.[Show abstract] [Hide abstract]
ABSTRACT: Objective: Individuals with decreased thiopurine methyltransferase (TPMT) activity are at risk of adverse effects of thiopurine administration whereas its increased activity may inactivate drugs faster. We evaluated genotype-phenotype correlations in patients with suspected hematological malignancies and inflammatory bowel disease from our region based on findings of nonlinear TPMT enzyme kinetics previously unreported. Patients and Methods: The study group comprised 267 individuals. They were screened for the most common variants of low TPMT activity. TPMT activity was measured in erythrocytes using the HPLC rate-blanked method. Results: Thirty-three patients (12.4%) were heterozygous (26 were TPMT*1/*3A, 5 TPMT*1/*2, 2 TPMT *1/*3C) and 1 was a compound heterozygote (*2/*3A). Normal and low normal TPMT activities substantially overlapped in wild-type and heterozygous individuals, whereas high activities were found in 29 wild-type genotyped patients. Extreme and life-threatening toxicity was observed in the compound heterozygote patient. Conclusion: Activity measurement performed at diagnosis provides clinicians with information on immediate pharmacokinetic-related adverse events and/or hypermetabolism, and genotyping may indicate the rate of pharmacodynamic thioguanine nucleotide accumulation due to slower overall thiopurine metabolism. © 2014 S. Karger AG, Basel.Oncology 03/2014; 86(3):152-158. · 2.17 Impact Factor
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ABSTRACT: Vitamin D is the third steroid hormone playing important bio-logical roles in the development of breast cancer. Decreased plasma levels of its 25- hydroxyderivative, 25OHD, display robust associations with higher incidence of breast cancer and shorter overall survival. Although no consensus exists, most authors agree that optimal plasma levels shall be within 75- 150 nmol/ l whereas levels higher than 375 nmol/ l can be potentially toxic with higher risk of hypercalcemia. To date, no data are available on the optimal levels of vitamin D related to the risk of breast cancer development, its phenotype features and the course of the disease. Published studies mostly describe associations among higher levels of 25OHD and lower bio-logically aggressiveness of the tumor. The polymorphism of VDR gene coding for the steroid receptor for vitamin Dmay be associated with higher disease incidence and also be of negative prognostic significance in breast cancer. This review presents an overall summary of the current knowledge and publications on vitamin D and breast cancer. Key words: vitamin D - 25- hydroxyvitamin D - vitamin D receptor - breast cancer This work was supported by the European Regional Development Fund and the State Budget of the Czech Republic (RECAMO, CZ.1.05/2.1.00/03.0101) and by MH CZ - DRO (MMCI, 00209805) and BBMRI_CZ (LM2010004). The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study. The Editorial Board declares that the manuscript met the ICMJE "uniform requirements" for biomedical papers.Submitted: 29. 1. 2014Accepted: 5. 5. 2014.Klinická onkologie: casopis Ceské a Slovenské onkologické spolecnosti 01/2014; 27(Supplementum):143-149.
Article: [Clinical evaluation of new drugs against orphan diseases in oncology - the current situation in Europe and in our country].[Show abstract] [Hide abstract]
ABSTRACT: Cancer represents one of the main causes of death among diseases across the age spectrum. Tumors in children, however, represent less than 1% of the total number of cancers in the population and in terms of the definition of orphan diseases in Europe are all children's cancers considered as orphan diseases. This is the reason why the research and development of new agents against cancer in childhood stands outside of the main interest. Every year around 30,000 new cases of cancer in children and adolescents are diagnosed in the European Unioun (EU) and approximately 80% of them achieve long-term remission using mainly conventional methods of treatment. However, almost 6,000 children and adolescents die every year of malignant tumors therefore cancer remains a major cause of morbidity and mortality. Consequently, there is a demand for new and safe drugs for children suffering from cancer which would lead to improved survival and to risk reduction of late adverse effects of cancer treatment. In the past 10 years in the EU, more in the EU-15 than in our country, 20 performed oncology trials in phase I involving adults account for only one trial in pediatric patients. The issue of new drugs clinical testing in rare cancers is very complex, complicated and for current unsatisfactory situation might be responsible various aspects. These aspects contain the legislative field, the problem of determining the correct dose of testing drug as a single agent or in combination therapy, the use of testing drug in advanced disease or already in de novo diagnosed patients, as well as equity (equal) access to new drugs being tested, the goal set for each molecule/drug in clinical trials, the conflict of interest balanced with sufficient professionalism and last but not least, the need for new methodologies and statistical approaches. The aim of this article is to describe the issue complexity of incorporation of new, modern drug for cancer patients with orphan diseases, including children.Key words: clinical evaluation - new drugs - orphan diseases in oncology.01/2014; 60 Suppl 2:80-5.
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ABSTRACT: With the recent addition of anti-angiogenic agents to cancer treatment, the angiogenesis regulators in platelets are gaining importance. Platelet factor 4 (PF-4/CXCL4) and Connective tissue activating peptide III (CTAP-III) are two platelet-associated chemokines that modulate tumor angiogenesis, inflammation within the tumor microenvironment, and in turn tumor growth. Here, we review the role of PF-4 and CTAP-III in the regulation of tumor angiogenesis; the results of clinical trial using recombinant PF-4 (rPF-4); and the use of PF-4 and CTAP-III as cancer biomarkers.Journal of Hematology & Oncology 06/2013; 6(1):42. · 4.46 Impact Factor
Article: [Vitamin D: Its physiology, pathophysiology and significance in etiopathogenesis of malignant diseases].[Show abstract] [Hide abstract]
ABSTRACT: Vitamin D is an endogenous product of mammalian organisms from which an active agent of a steroid hormone nature is synthesized. These hormones participate in a variety of key metabolic processes in every nuclear cell, whether on endocrine, paracrine and autocrine or subcellular level. Vitamin D represents a very interesting molecule which participates in a great deal of body processes. This review summarizes the findings about the metabolism of vitamin D focusing on pathophysiology of malignant diseases. Keywords: vitamin D - malignant diseases - metabolism of vitamin D - anticancer effects of vitamin D.Casopís lékar̆ů c̆eských 01/2013; 152(1):20-30.
Article: Metronomic chemotherapy with the COMBAT regimen in advanced pediatric malignancies: a multicenter experience.[Show abstract] [Hide abstract]
ABSTRACT: The outcome of children with refractory/relapsed malignancies remains poor and novel therapies are urgently required. One of the promising approaches is metronomic chemotherapy. We present the clinical results of 74 children with advanced solid tumors treated according to treatment recommendation with data registry in three European pediatric centers. COMBAT (Combined Oral Metronomic Biodifferentiating Antiangiogenic Treatment) included low-dose daily temozolomide, etoposide, celecoxib, vitamin D, fenofibrate and retinoic acid. From 2004 to 2010, 74 children were enrolled. The 2-year overall survival (OS) was 43.1% (median 15.4, range 1.3-69.9 months). Of the 74 patients, 50 patients (68%) died and 24 are alive: 6 (8%) with progressive disease, 7 (9%) with stable disease/partial response and 11 (15%) in complete response. Median time to response was 6 months. Of 62 patients with initially measurable disease, 25 (40%) had radiological response or stable disease. Fourteen of 25 showing clinical benefit responded within the first 6 months. The treatment was well tolerated on an outpatient basis. Regarding non-hematological toxicity of grade ≥2, hepatotoxicity of grade 3 occurred in 8 children and grade 3 cheilitis in 16 children. COMBAT is a feasible and effective treatment option for patients with relapsing/refractory malignancies. The treatment is well tolerated with a low acute toxicity profile.Oncology 04/2012; 82(5):249-60. · 2.17 Impact Factor
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ABSTRACT: Phase I trials in oncology usually enrolling patients with advanced disease who have failed standard treatment options. The primary endpoint of these studies is to establish the recommended dose and/or schedule of new drugs or drug combinations for phase II trials. The guiding principle for dose escalation in phase I trials is to avoid unnecessary exposure of patients to sub-therapeutic doses of an agent. The mission of phase I clinical trials is to accelerate the development of new anticancer drugs with the purpose of improving quality of life and survival for patients with cancer.Klinická onkologie: casopis Ceské a Slovenské onkologické spolecnosti 01/2012; 25 Suppl 2:2S98-101.
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ABSTRACT: CD3+ CD56+ NKT-like cells have been shown to produce substantial amounts of pro-inflammatory cytokines and to mediate lysis of malignant cells. Using flow cytometry, we evaluated the absolute NKT-like cell count in peripheral blood from individuals in a reference population and the median number was 0.085 x 10(9)/l. The average number of NKT-like cells in patients with disseminated cancer was 2.65 fold higher than in the reference population. The number of CD3+ CD56+ cells in solid tumour patients who achieved complete remission was comparable to the reference population. In breast cancer patients with initially (prior to therapy) increased number of NKT-like cells, we observed a trend toward longer disease-free survival. Thus we conclude that CD3+ CD56+ NKT-like cells have potential to suppress tumour evasion and are expanded in peripheral blood of some epithelial tumour patients.Klinická onkologie: casopis Ceské a Slovenské onkologické spolecnosti 01/2012; 25 Suppl 2:2S21-5.
Article: [The current development of new drugs for solid tumors--change of view on the optimal design of clinical trials].Klinická onkologie: casopis Ceské a Slovenské onkologické spolecnosti 01/2011; 24(1):54-5.
Article: [KRAS mutation testing in therapeutic algorithm for treatment of metastatic colorectal carcinoma].[Show abstract] [Hide abstract]
ABSTRACT: Targeted therapy has become an integral part of treatment procedures of malignant tumors. Colorectal carcinomas are frequently targeted with monoclonal anti-EGFR antibodies (cetuximab and panitumumab). Activating somatic mutations in codons 12 and 13 of the exon 2 of KRAS gene are considered negative predictive factors of response to anti-EGFR therapy in patients with metastatic colorectal cancer. In the Czech Republic, evaluation of mutational status of KRAS gene is performed in several referral laboratories. In 2009, these laboratories performed 2580 tests of the KRAS mutational status--out of these, 60.2% cases reported non-mutated, wild-type KRAS. In one of the referral laboratories, we demonstrate the logistics of KRAS testing procedure. Stratification of patients with metastatic colorectal tumors based on their KRAS mutational status has evolved to a standard procedure. Laboratories performing these methods shall therefore adhere to the recommendations of the professional and accredited societies.Casopís lékar̆ů c̆eských 01/2011; 150(6):321-6.
Article: Vysetreni mutacniho statutu genu KRAS jako soucast algoritmu lecby metastatického kolorektalniho karcinomu[Show abstract] [Hide abstract]
ABSTRACT: VOD Zhoubné onemocnění tlustého střeva (dg. C18), rektosig-moideálního spojení (C19) a konečníku (C20) je jednou z nej-častějších malignit v České republice. Nejčastější léčebnou modalitou u kolorektálního karcinomu je kurativní resekce ná-doru. Pacientům s karcinomem tlustého střeva klinického sta- Karlova v Praze, Lékafiská fakulta Hradec Králové, Ústav klinické biochemie a diagnostiky FN 3 P & R LAB a.s., Nov˘ Jiãín 4 CGB laboratofi a.s., Ostrava 5 Univerzila Palackého v Olomouci, Ústav molekulární a translaãní medicíny LF 6 Fakultní Thomayerova nemocnice s poliklinikou v Praze, Oddûlení patologie a molekulární medicíny 7 Bioptická laboratofi s.r.o., PlzeÀ 8 Univerzita Karlova v Praze, 1. lékafiská fakulta, Ústav patologie VFN 9 Univerzita Karlova v Praze, Lékafiská fakulta Hradec Králové, FingerlandÛv ústav patologie FN SOUHRN01/2011;
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ABSTRACT: Targeted biologic therapy has been proven to be effective compared to the current therapy of metastatic renal cell carcinoma (mRCC) in clinical studies as well as in actual clinical practice, but its high cost is a potentially limiting factor. Since the local cost-effectiveness analysis is missing, we assessed the cost of sunitinib and sorafenib in the treatment of mRCC in a comprehensive cancer centre. A total of 31 patients were treated with sunitinib and/or sorafenib between 06/2006 and 09/2009 and then followed for at least 12 months. Clinical (disease progression, adverse events, dose reduction) and cost data (medication, examination, hospitalization) were assessed in the comprehensive cancer centre (1 Euro = 25.78 CZK). The multikinase inhibitors were the second line treatment for most patients after INF-alpha therapy failure (86.7%). The mean cost per month to progression (PD) was 94,141.8 CZK/3651.7 Euro (sunitinib: 11 months to PD, cost to PD 1,267,648.5 CZK/49,171.8 Euro; sorafenib: 8 months to PD, cost to PD 896,670.1 CZK / 34,781.6 Euro). The incremental cost-effectiveness ratio was 123,659.5 CZK / 4796.7 Euro per progression-free month in sunitinib vs sorafenib patients. The mean cost per month after PD was 45,767.0 CZK/1775.3 Euro with sequential therapy (sorafenib after sunitinib failure and vice-versa in more than half of patients) or best supportive care. 16 patients died during the study period with mean cost of 1,180,795.4CZK/45,802.8 Euro per 12 months (median between treatment initiation with sunitinib or sorafenib and death). 8 patients (26%) did not achieve progression (median progression-free survival to 09/2009: sunitinib 18 months, sorafenib 14 months). The cost of medication made up more than 95% of total costs to PD and more than 90% after PD. The cost per progression-free month was 123,659.5 CZK/4796.7 Euro in mRCC patients treated with sunitinib vs sorafenib.Klinická onkologie: casopis Ceské a Slovenské onkologické spolecnosti 01/2010; 23(6):439-45.
Article: PCN85 SORAFENIB AND SUNITINIB IN METASTATIC RENAL CELL CARCINOMA: COST-EFFECTIVENESS ANALYSIS IN REIMBURSEMENT PROCEEDINGS VS. DATA FROM CLINICAL PRACTICEValue in Health 01/2010; 13(7). · 2.19 Impact Factor
Article: [New radiopharmaceuticals and positron-emission tomography applications at the Masaryk Memorial Cancer Institute in Brno].[Show abstract] [Hide abstract]
ABSTRACT: The construction and launch of the cyclotron & PET centre at the Masaryk Memorial Cancer Institute, which is run in cooperation with the Nuclear Research Institute Praha-Rez, allows the Masaryk Memorial Cancer Institute to engage in the research, development and application of new radiopharmaceuticals including compounds labelled by short-living positron emitters (especially 11C). For the immediate future, new projects are planned, e.g. using the proliferation marker 18F-fluoro-L-thymidine, or neuro-oncological studies using the proteosynthesis and amino acid transport marker 11C-methionine, and eventually also other compounds applicable outside of oncology. The existence of the PET centre at the Masaryk Memorial Cancer Institute therefore offers a wide range of possibilities to both patients and physicians in the Brno region and beyond.Klinická onkologie: casopis Ceské a Slovenské onkologické spolecnosti 02/2009; 22(3):94-7.
Article: PCN55 THE ECONOMIC EVALUATION OF SUNITINIB AND SORAFENIB IN MRCC PATIENTS IN THE CZECH REPUBLICValue in Health 01/2009; 12(7). · 2.19 Impact Factor
Article: Pretreatment plasma folate modulates the pharmacodynamic effect of high-dose methotrexate in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma: "folate overrescue" concept revisited.[Show abstract] [Hide abstract]
ABSTRACT: To evaluate the influence of pretreatment plasma folate concentrations on methotrexate exposure in children with acute lymphoblastic leukemia/non-Hodgkin lymphoma treated with high-dose methotrexate, we assessed time profiles of plasma homocysteine, folate, and vitamin B(12) concentrations in children treated with high-dose methotrexate with leucovorin rescue. We analyzed 98 treatment courses. The study endpoints were to determine how methotrexate exposure is related to homocysteine accumulation and whether it is influenced by pretreatment plasma folate. Peak concentrations of homocysteine increased from the start of the intravenous infusion through cessation of methotrexate therapy up to time point t(42), when this trend was reversed by administration of folinic acid. The area under the curve (AUC) for plasma homocysteine showed decreasing course-to-course tendencies with a statistically significant decrease only between courses 1 and 2 (P <or=0.05), indicating decreased whole-body homocysteine accumulation in response to administration of consecutive methotrexate courses. Therapeutic courses with low initial folate concentrations (<or=10 nmol/L) gave significantly higher responses in homocysteine accumulation expressed both as (hcys)AUC(0-66 h) and the peak t(42) homocysteine concentrations than did courses with initial folate >10 nmol/L. Correspondingly, in the courses with low initial folate, peak plasma concentrations of methotrexate were significantly higher than in courses with high precourse concentrations of plasma folate. Endogenous pretreatment plasma folate modulates the magnitude of the methotrexate effect, providing support for a "folate overrescue" concept.Clinical Chemistry 04/2006; 52(4):692-700. · 7.15 Impact Factor
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ABSTRACT: Vacuum biopsy device (mammotome) was primary developed for invasive diagnosis of the mammary gland. In Radiological department of Masaryk Memorial Cancer Institute we use the mammotome not only for breast tissue sampling. The device is used also for extraction of tumor specimens in advanced epithelial, mesenchymal or the other histological type of tumors for further chemoresistance testing.Casopís lékar̆ů c̆eských 02/2006; 145(5):399-402; discussion 402-3.
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ABSTRACT: The primary endpoint of this study was to evaluate the efficacy (objective response rate; ORR) of combined chemotherapy with raltitrexed plus oxaliplatin as second-line treatment in patients with metastatic colorectal cancer (CRC). Secondary endpoints were overall survival (OS), time to progression (TTP) and toxicity (NCI-CTC criteria). The target population were patients with metastatic colorectal adenocarcinoma who progressed after first-line chemotherapy. Treatment consisted of raltitrexed 3 mg/m2 as a 15-minute intravenous (IV) infusion followed 45 minutes later by oxaliplatin 130 mg/m(2) IV as a 2-h infusion on Day 1, repeated every 3 weeks until further disease progression (PD), unacceptable toxicity or the decision of the patient. A total of 51 patients, all with WHO performance status 0-2 received a median of 6 treatment cycles (range 1-11). After 3 cycles, 8 of the 47 evaluable patients (17%) had experienced an ORR, 28 patients (59.6%) had experienced stable disease (SD) and 11 patients (23.4%) had PD. After 6 cycles, 1 of the 29 evaluable patients (3.5%) had an ORR, 13 patients (44.8%) had SD and 15 patients (51.7%) had PD. After a median follow-up of 48.9 weeks, median TTP was 18 weeks and median overall survival was 54.4 weeks. Treatment was well tolerated; grade 3 toxicities occurred in only 5/51 patients (9.8%). The most common toxicities were paraesthesia (62.7%), diarrhoea (23.5%), nausea (41.2%), vomiting (33.3%), hepatotoxicity (25.5%), and hematological toxicity (41.2%). In conclusion, the combination of oxaliplatin plus raltitrexed appears to be effective and well tolerated as second-line therapy in patients with disseminated CRC.Neoplasma 02/2006; 53(2):119-27. · 1.57 Impact Factor
Article: Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate.[Show abstract] [Hide abstract]
ABSTRACT: Plasma homocysteine has recently been associated with the occurrence of methotrexate-related neurotoxicity. We observed extreme elevations of homocysteine in a 9-year-old boy presenting with leukemia treated with the ALL-BFM 95 protocol. Coma occurred at about the 71st hour from the first methotrexate administration, and lasted for 30 h but MRI and CT studies showed no intracranial pathology. The second course of high-dose methotrexate was administered with no complications. Homocysteine areas under the curve (AUC) were calculated as the sum of areas of rectangles during the 6-hour intervals from T(0) to T(72) hours (AUC(0--72)) and methotrexate AUCs were evaluated using MW/PHARM 3.3 software. The AUC of homocysteine during the first, toxic course was 5.2 times higher than AUC during the second administration, whereas AUC of methotrexate also differed by a factor of 5. Plasma concentrations of folate prior to the first and the second courses, respectively, were 4.4 versus 45 micromol/l making this difference the most striking discriminator between the two courses. Mutation analysis showed that the patient was heterozygous for the C 677 T mutation in the MTHFR gene. We suggest that plasma homocysteine, pretreatment plasma folate and possibly the presence of MTHFR mutations may be biomarkers of methotrexate toxicity and possibly its antifolate effect targeted towards the tumor as well.Oncology 02/2005; 69(3):269-72. · 2.17 Impact Factor
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ABSTRACT: The majority of patients with breast carcinoma receive chemotherapy as a component of multimodality treatment. Over the past decade, it has become increasingly more common to deliver chemotherapy first, but this has raised new questions within all disciplines of cancer management. However, the effect of cytotoxic treatment cannot be predicted on individually specific basis, then identification of tumor characteristics associated with tumor therapeutic response and outcome is then of great clinical interest. We studied 141 patients at Masaryk Memorial Cancer Institute, who received neoadjuvant chemotherapy and/or chemotherapy + radiotherapy (CHT/CHT+RT) between 1994-2002. Tumor samples were taken prior to and after neoadjuvant therapy. We quantified the response to therapy pathologically and determined histological and molecular tumor characteristics (steroid receptors, CEA, Ca 15-3). In addition to therapeutic response as immediate outcome, event free survival (EFS) was examined as more complex primary end-point of the study. Complete remission (CR) has been achieved in 6.5%, partial remission (PR) in 49.6%, stable disease (SD) in 26.2% and progression disease (PD) in 17.7% patients. Patients were divided into two groups according to the result of neoadjuvant therapy--responders (CR+PR+SD, who successfully underwent surgery), and risk group (patients with SD or PD, who could not undergo surgery). Responders to neoadjuvant CHT/CHT+RT regimens reached statistically significant better EFS than non-responders, low tumor size (T2) and stage (II) categories were confirmed as additional predictive factors not only for EFS but for therapeutic response as well. The study primarily examined predictive power of tumor markers as CEA, Ca 15-3, and steroid receptors (ER/PR) and searched for their role in the prospective evaluation of neoadjuvant therapy. We evaluated these factors as potential predictors of EFS, independent in predictive power on therapeutic response to neoadjuvant therapy. Diagnostically valuable cut off points were proposed in ROC analysis for all these markers. Responders to the neoadjuvant therapy with Ca 15-3 <23.0 kU/l, CEA <5.0 mg/l, estrogen receptors (ER) >5.0 fmol/mg or both estrogen /progesterone receptors (ER/PR) positive had statistically significantly better EFS in comparison to patients with Ca 15-3 >23.0 kU/l, CEA >5.0 mg/l, ER <5.0 fmol/mg, or other cases than patients double positive in ER/PR. Marker Ca 15-3 revealed significant predictive power even within the group of non- responders, these patients with Ca 15-3 <23.0 kU/l had better EFS as compared to patients with Ca 15-3 >23.0 kU/l. Tumor size and low stage proved predictive value for immediate response to neoadjuvant therapy. Risk parameters for neoadjuvant therapy were T4, stage III, namely if RT was necessary. Therapeutic response to neoadjuvant therapy was independent on investigated molecular parameters, but there was strong predictive association of Ca 15-3, CEA and ER/PR receptors with event free survival development. Diagnostically valuable cut-off points were proposed and validated for sensitivity and specificity in ROC analysis.Neoplasma 01/2004; 51(6):471-80. · 1.57 Impact Factor
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Masaryk Memorial Cancer InstituteBrünn, South Moravian, Czech Republic


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Directions column— by Alvin Taylor
During the past two years of penning "Directions," for South Carolina Wildlife, I've shared many of my experiences growing up in rural South Carolina. You have seen how my outdoor adventures shaped who I am today and the very significant part they played in my choosing the career that I enjoy now. In the "DNR Insider" feature in this issue (beginning on page 48), readers will get a glimpse into the fantastic work being done for our state's youth by the staff of our Hunter Education section and Take One Make One (TOMO) program.
Across our agency, we have a strong commitment to providing positive outdoor experiences for young people. I was blessed to have a dad who shared his love of the outdoors and instilled that love in me, but not every child is so lucky. In our hunter education classes, we endeavor to give each and every student a taste of what it means to be a sportsman, as well as an introduction to the ethical and wise use of our state's natural resources, and through the TOMO program, young people who might not otherwise be able to experience a hunt are provided hands-on opportunities to go hunting for the first time. This does not just happen. It takes many private landowners willing to share their land, mentors willing to share their time and DNR staff with a strong commitment to youth to provide these great - perhaps life-changing - outdoor experiences.
The DNR also supports more than 250 schools across the state with competitive archery programs through the Archery in the Schools program. Another great first step! And whether you are a student in an urban or a rural county, you still have this opportunity available to you. Each year during the Palmetto Sportsmen's Classic, the DNR hosts a state championship archery tournament, with trophies awarded by school and age group. This is an exciting event with hundreds of participants. Join us this year! Hats off to those school administrators who recognize the importance of this program for their students.
When I was growing up, I could hunt and fish almost anywhere. Sadly, it's not the same today. DNR property managers, technicians and other employees work hard to provide youth-only hunting days on many of our Wildlife Management Area properties, giving young people another opportunity to spend time in South Carolina's great outdoors. These folks spend many hours preparing fields, deer stands and waterfowl impoundments, and when the big day arrives, they are just as excited as the youth who come to hunt.
We ALL remember the first fish we caught (I find myself smiling now, just thinking about that fish), and DNR-organized Fishing Rodeos are introducing young people across the state to fishing. We could not provide these events without the support of local citizens in each community. Nearly four hundred youth participated recently in a Fishing Rodeo in Darlington County. This event was made possible because a local landowner, Allen Holloman, donated his time and his pond, and state legislators, led by Senator Gerald Malloy, partnered with DNR staff and Department of Natural Resources Board member Randy Lowe to provide a day of fishing and hot dogs. Fishing and hot dogs . . . it doesn't get any better than that, and at the end of the day, one young person's name was drawn to receive a lifetime fishing license. It was a good day, a great experience and a valuable investment in the future of our natural resources.
— Alvin Taylor, Director
South Carolina Department of Natural Resources


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Turkey Digital TV News
Amino to provide STBs for Turkcell Superonline IPTV services
Nov 10, 2014 – Amino has announced that it has secured a contract from Turkcell to provide its Live Advanced Media Platform for the rollout of IPTV services. The operator has begun rolling out its Turkcell TV+ service as part of an enhanced 'tripleplay' multiscreen offering.
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Turkcell TV+ set-top box launches in Turkey
Oct 17, 2014 – Turkcell (NYSE: TKC, BIST: TCELL) has announced that Turkcell TV+, which was previously offered only on mobile devices and computers, will now be available on television sets.
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TTNET brings ARRIS IPTV set-top experience to Turkey
Sep 8, 2014 – ARRIS (NASDAQ: ARRS) has announced that Turkey's TTNET has successfully rolled out ARRIS VIP1113 IPTV set-tops to subscribers of its Tivibu service as it enhances its high definition (HD) TV offering.
News categories: ARRIS Group, TTNET, Sahin Sen, Steve McCaffery, Digital TV, IBCShow, IPTV, Set Top Box, Turkey
AirTies and Octoshape selected by Digiturk for international OTT service
Jul 28, 2014 – AirTies and Octoshape have announced that Digiturk has selected their joint solution to deliver premium programming over-the-top (OTT) to its international customers.
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Türk Telekom IPTV subscribers down 6,000 in 2Q 2014
Jul 21, 2014 – Türk Telekom has announced 2014 second quarter results. Türk Telekom's Tivibu service ended with 1.9 million TV subscribers, up 1.3% in the quarter. Of the total, the number of IPTV subscribers was 302,000, down 6,000 quarter-on-quarter.
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TURKWEB selects Erstream and Octoshape for OTT VOD service
May 12, 2014 – Erstream and Octoshape have announced that they have been chosen by TURKWEB, a provider of high definition content including movies and TV series, to provide broadband TV VOD distribution services to customers globally.
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Rovi entertainment discovery and monetization technologies for Grundig TVs
Mar 18, 2014 – Rovi (NASDAQ: ROVI) has announced that Grundig has signed agreements for the use of Rovi TotalGuide CE and Rovi Advertising products in Grundig LED TVs distributed in Germany, the Nordic region, Western Europe, Turkey, and Russia.
News categories: Rovi Corp, Grundig, Akin Garzanli, Pim Versteeg, Advertising, Denmark, Europe, Finland, Germany, Iceland, Middleware, Norway, Russia, Smart TV, Sweden, Turkey
Doğuş Media chooses Kaltura video platform for tvyo OTT service
Feb 18, 2014 – Kaltura has announced that it has been selected by Doğuş Media Group (DMG) to power the Turkish conglomerate's multi-screen, multi-platform, ad-funded video service, tvyo.
News categories: Kaltura, Doğuş Media, tvyo, Alp Ocal, Ron Yekutiel, Digital TV, Infrastructure, Media Player, Multiscreen, OTT, Turkey
Pay TV revenues in MENA to grow more than 83%
Jan 22, 2014 – Pay TV revenues in the Middle East and North Africa will grow by more than 83% between 2010 and 2020 to $5.60 billion, according to a new report from Digital TV Research.
News categories: Cable TV, Digital TV, Digital TV Research Reports, Egypt, IPTV, Israel, Kazakhstan, Market Research, Middle-East, Satellite, Saudi Arabia, Subscribers, Terrestrial, Turkey, UAE, Uzbekistan
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HOULKA – Hundreds will be fed Thanksgiving and hundreds of gifts will be sold for Christmas at two closely linked events in Houlka this holiday season. The Houlka Community Thanksgiving will see more than 500 meals prepared for needy families, the elderly, county inmates and law enforcement officers on Thanksgiving Day. This will be backed […]
Tag Archives | Houlka Helping Hand
Houlka preps for holiday events
By Floyd Ingram | 12:55 PM | November 27, 2013 | Business, Living, News
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"I knew I should've made a left turn at Albuquerque."
Bugs Bunny (1953)
Albuquerque is the crossroads of New Mexico, and Bugs Bunny isn't the only one that's ended up in the boonies with a wrong turn here. This is where the desert meets the mountains, the high plains transform into forest, and a whole lotta nothing goes off to each side. It's a southwest melting pot and contains a little bit of everything in New Mexico all wrapped up in one. And of course, it's the largest city in the state.
Albuquerque was founded in 1706 by Don Francisco Cuervo y Valdes as the Spanish colonial outpost Ranchos de Alburquerque. It straddles the Rio Grande almost exactly in the central part of the state, and retains both Spanish and traditional Indian heritage. In the early 1900's growth followed the famous "mother road" of Route 66 that passed right through town, and by 1950 Albuquerque gained a whole new reputation with Sandia National Laboratories and the coming of the Atomic Age.
And it's all still here…
You can walk through tradition in Old Town, catch a few pieces of iconic American history along Route 66 in Nob Hill, see some traditional Indian rock carvings at the Petroglyph National Monument (with doggie in tow, of course), explore the Atomic Age at the National Museum of Nuclear Science, and finish it all off with a panoramic view from one of the world's longest tramways atop Sandia Peak. If you want the full party come back and experience the whole thing all over again during the spectacular annual Balloon Festival in fall.
We spent a cool few days exploring the city and the surroundings, managing to squeeze in a dinner with one of Paul's old highschool buddies as well as sampling some excellent Southwestern food (watered by a few tasty margaritas, of course) at Sadie's.
This town definitely has a cool vibe and a bit of something for everyone. Just remember to take that left turn before you leave…
6 Responses to A Quick Left Turn at Albuquerque, NM
Jon & Sue Francis says:
Are they still having the old western gunfights in Old Town?
Jerry and Suzy LeRoy says:
Although we profess to hate big cities (especially for driving) there are many that have great things to offer even the most conservative of tastes. Albuquerque is certainly one that sounds like fun. Oklahoma City presented some features both gratifying and sobering. San Francisco is a must. Thanks for the quick tour of Abuquerque, showing us treasures yet to delve into!
libertatemamo says:
You know I'm with you. We're not major city folks in our RV, but there's a few spots we really like.
We lived in San Francisco for years and do LOVE that town. Austin was excellent too,
and Albuqueque was a nice mix…although it's New Mexico's biggest city it's still
pretty small by most standards and had alot of nice nature in the surrounding area.
Just wish there was a State Park closer to town there.
Marsha says:
We had sooooo much fun when we were there. We volunteered for 12 days at the Balloon Fiesta. You two should look into that. You get your boondocking free, breakfast, snacks, 3 big events…one in the Zoo…sweatshirts and other stuff free. We loved it.
Tell Paul he looks real good sitting in that chair.
libertatemamo says:
What a fabulous idea!! I will have to look into that.
Oh, and by the way Paul loved the compliment…he's always complaining to me
that the ladies don't notice him anymore, so he's a happy man
John Deeth says:
My bet is that the left toin at Alba-koi-kee was specifically the Y shaped intersection with New Mexico 194:
"Route 66 is clearly shown following the course of Central Avenue. After passing downtown, the road angles slightly to the right, parallelling the river. Just after the Albuquerque Country Club (depicted rather prominently), it makes a left turn to approach the crossing of the Rio Grande."
Maps here: http://www.route66university.com/maps/newmexico.php
Looks like it would be VERY easy for a confused cross-country traveler to veer right onto 194 instead of taking that left toin. It was probably notoriously well known by 40s era southern Californians.
Of course, since Bugs generally traveled by tunneling underground rather than surface routes, I may be wrong.
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international journalism
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Oppressed journalists are having their say online
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For three years, Ecuadorean journalist Lindon Sanmartín Rodriguez and his brother Pablo hosted a freewheeling talk radio show that analyzed... More
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Reporters enjoy new freedoms in a long-repressive society
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Journalism in Nigeria has never been easy work, and the new Freedom of Information Act (FOIA), which finally became law... More
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"[T]here was little that justified CNN's egocentric coverage"
Which media outlets use 'illegal immigrant'? (Fusion)
"[I]n spite of all the good reasons not to use the phrase, it is still very easy to find in the US press, even in headlines"
Jack Shafer on losing his job (Capital New York)
"Right now, my immediate plan is to go to work as a lay therapist at The Intercept to bring the healing there so John Cook and Matt Taibbi can return. I have great interpersonal skills."
On outlets that continue to call unknown drone victims 'militants' (The Intercept)
"Like the US drone program itself, this deceitful media practice continues unabated"
Greg Marx discusses democracy and news with Tom Rosenstiel of the American Press Institute
CJR's Guide to Online News Startups
ACEsTooHigh.com – Reporting on the science, education, and policy surrounding childhood trauma
Who Owns What
The Business of Digital Journalism
A report from the Columbia University Graduate School of Journalism
Questions and exercises for journalism students.
Should all journalists be on Twitter? – Reasons to take up or forgo the 140-character platform
Is it ever okay to name victims? – Editors question the policy of omitting information in sexual assault and domestic violence cases


text:
So what do you think of the Typhon Pact (as an organization)?
View Single Post
June 22 2013, 09:40 PM
Location: Arizona, USA
Re: So what do you think of the Typhon Pact (as an organization)?
Christopher wrote:
tomswift2002 wrote:
Back with "Singular Destiny" I thought that the Typhon Pact would make an interesting enemy, but since then I haven't really found the Pact to be that enemy that they were setup to be. I've read up to Brinkmanship, but right now I've found the Pact is more of a mouse giving off the roar of a tiger and doesn't really seem to be as big of a threat, or even be in the same class of enemy to the Federation as the Cardassians/Dominion or the Borg.
See, that's the mistake people keep making. The Pact was never meant to be just another Big Bad, another basis for war stories.
was the biggest war/action story you could ever have, and in the wake of that it would've been foolish to try to top it, so the decision was made to go in a different direction, a subtler and more sociopolitical direction. The big conflict is ended, the chessboard has been knocked over, and now the survivors have to rebuild, to establish new relationships and power dynamics, to try out new approaches in a new, transformed galaxy. Powers that once dominated the quadrant are weakened, and that opens the door for formerly marginalized powers to become prominent, and they're jockeying for position and advantage both with the old powers and with one another.
I'm very glad this didn't just turn into another war story. What we've gotten so far has been a lot more interesting, IMO, than if they had turned the TP/KA conflict into just another big shooting war.
They say a little knowledge is a dangerous thing, but it is not one half so bad as a lot of ignorance. - Terry Pratchett,
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The bakers behind Cupcake.Love.Miami fill their huge menu of desserts with unexpected and creative flavors. Some emulate childhood favorites, such as the PB-and-J-inspired Goober and watermelon Jolly Rancher. Other categories are dedicated to refreshing summer beverages, breakfast staples such as Froot Loops, and seasonal flavors such as pumpkin pie. These flavors take shape as cupcakes, cake pops, or full-grown cakes that can feed up to 95 people and arm as many food catapults. No matter what its shape or size, each dessert flaunts a distinct artistic vision with intricate fondants and other toppers.
The gourmet treats at Häagen-Dazs delight discerning palates with a variety of frozen goodies in indulgent flavors. Made from top-quality ingredients, Haagen-Dazs ice creams and sorbets confidently fill cups and top cones ($4.20-$6.00) or blend into shakes ($6.25) and smoothies ($6.50) in an attempt to lose taste-bud tails. Each Dazzler's three scoops of ice cream settle under whipped-cream peaks, with flavors including Dulce Split, Mint Chip, and Rocky Road ($6.95). Patrons select toppings, sauces, and ice-cream flavors to form customizable sundaes ($5.50-$6.95), or deploy straws to taste a Sorbet Sipper ($5.95), which is made of sorbet and then sipped.
Betty Marichal founded Miami Spice Bakery as an oasis for those seeking sumptuous fresh-baked desserts, without the diet guilt. This means almond and pumpkin cakes, homemade bread, brownies, and delicious flan––all completely free of lactose. The bakery's cakes are sugar free, sweetened naturally with top-shelf liquors, and can be purchased gluten free. Clients may also solicit the bakery for an elaborate custom-decorated cake to woo a lover or stone-faced judge.
Brothers of Brooklyn serves up an extensive menu of breakfast and lunch offerings in a New York–style atmosphere. Meander in morning or afternoon to munch bagels decked out in spreads, veggies and meats, egg breakfasts, and latter-day sandwiches. Breakfast specials (served until 11:30 a.m.) offer patrons prototypical morning fare, such as a trio of chocolate-chip pancakes served like a decadent subpoena with a choice of bacon or sausage ($5.95). Meanwhile, the all-day breakfast lineup features egg-centric eats, including a spanish omelette stuffed with green peppers, onion, pepperoncini, tomato sauce, and cheese, and served on a novelty-size pair of castanets ($6.75). Fresh-baked bagels ($0.80, $1.95 with cream cheese) are also available throughout the day and come in 10 varieties, running the gamut from sweet (e.g., cinnamon raisin and blueberry) to savory (e.g., onion and everything bagels).
InStyle Cupcakes is known by many in the Miami-Dade and Broward areas to provide the most delicious cupcakes for every event, occasion, and holiday.
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1. Fifty Shades of Grey by E.L. James
2. I, Michael Bennett by James Patterson,
Michael Ledwidge
3. Zoo by James Patterson, Michael Ledwidge
4. Wicked Business by Janet Evanovich
5. Friends Forever by Danielle Steel
6. 11th Hour: Women's Murder Club
by James Patterson, Maxine Paetro
7. Fifty Shades Freed by E.L. James
8. The Casual Vacancy by J.K. Rowling
9. Guilty Wives by James Patterson, David Ellis
10. Innocent by David Baldacci
1. Heaven is for Real: A Little Boy's Astounding Story of his Trip to Heaven and Back by Todd Burpo
2. Wild: From Lost to Found on the Pacific Crest Trail by Cheryl Strayed
3. Killing Lincoln: The Shocking Assassination
that Changed America Forever by Bill O'Reilly,
Martin Dugard
4. No Easy Day: The Firsthand Account of the Mission That Killed Osama bin Laden by Mark Owen, Kevin Maurer
5. Unbroken: A World War II Story of Survival,
Resilience, and Redemption by Laura Hillenbrand
6. Eat This, Not That!: The No-Diet Weight Loss
Solution by David Zinczenko
7. Act Like a Lady, Think Like a Man: What Men
Really Think About Love by Steve Harvey
8. The Amateur: Barack Obama in the White House by Edward Klein
9. In the Garden of Beasts: Love, Terror, and an American Family in Hitler's Berlin by Erik Larson
10. Grace: More Than We Deserve, Greater Than We Imagine by Max Lucado


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I've just recently painted two outside doors on my house. The one I painted last week looks good but I have just painted another door and it is a disaster. The first coat didn't cover it well and the second coat has all these runny streaks and bubbles. Help!!
- Forum >
- Home Design >
- Paint seems to thick?
What kind of paint did you use? Oil or latex? If you used the same paint on both doors, it sounds like there were different finishes for the old paints. You may have applied a latex over an oil-based without properly prepping it.
Sand down your current mess, clean and seal. Then try to repaint.
In any case, light sanding would have been necessary to break the seal of the old paint. A good cleaning comes next. An oil-based sealant, such as KILZ, should then be used; you can then apply either oil or latex over the KILZ.
Sand down your current mess, clean and seal. Then try to repaint.
exterior paint removing
Deck Painting/Staining
Paint Problem
insulation attic floor but insulation to thick
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Here, the former Jonas Brothers singer—now a burgeoning fashion plate and front row regular—shows you how to up your jacket game... more >
Fashion Week: The Men's Shows
Street Shooting Man
Photoblogger Tommy Ton captures the style moves of Fashion Week's men-about-town
1 of 79
"A notebook and a flipped-up collar that match: coincidence, or well-thought-out style? Either way, this guy's denim peacoat is a breath of fresh air from all the dark shades of wool I've been seeing."
Paris; January 24, 2010
Paris; January 24, 2010
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3 Bedroom 3.5 Bath Luxury At Its Finest
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Relevant offers
A war is being waged over the future of the humble letterbox, with Australia Post at loggerheads with high-tech joint venture Digital Post Australia (DPA).
Both are betting that Australians will gravitate to digital mailboxes, which allow users to receive and pay bills, communicate with their providers - such as banks, telcos, electricity networks and financial services firms - and store important documents such as passports and birth certificates.
They will be accessible anywhere in the world from PCs, tablets and smartphones and can support payments directly from the mailbox, with users automatically notified when they have new mail or their bills are overdue, for instance.
DPA chief executive Randy Dean said email was too insecure for transactional mail and most businesses did not send important documents over email for security and privacy reasons. Therefore, those who want to interact with providers online need to have individual accounts and logins with many different sites.
"Everybody has email but their transactional mail is something they largely get on paper," said Dean, adding the digital mailboxes verified both the sender and receiver of mail.
Guy Cranswick, an analyst at research firm IBRS, isn't convinced. "The digital post box seems like something that would have been innovative 10 years ago," he said.
Both Australia Post and DPA claim state-of-the-art security, but security experts including consultant Nigel Phair warn that there are risks with keeping such sensitive documents in the one place.
Phair said it would be a honeypot for identity thieves who could gain access using phishing attacks.
"This is the problem with putting all of your identity eggs in the one basket," he said.
Australia Post and DPA say their digital mailbox services are being privately tested by thousands of customers.
From Wednesday DPA is allowing users to sign up and create their verified mailbox but mail won't start flowing into it until early next year.
Australia Post was forced to suspend registrations for its Digital MailBox within days of it going online after discovering "a technical issue", but it is now back online, with a full launch also expected next year.
An Australia Post spokeswoman said the issue was not hacking related despite hacking being reported on other parts of its website around the same time. "The mailbox was never under threat and never compromised."
Australia Post unsuccessfully sued DPA claiming trademark and other infringements and is now appealing. Australia Post chief executive Ahmed Fahour told a Senate estimates hearing in October that the outcome was "a huge injustice".
Privately, Australia Post sources say DPA copied its idea, not just its name, but DPA says it had been in development for well over a year before Australia Post announced its service.
For Australia Post, its $2 billion digital transformation is seen as critical to the future of the business.
"We had a monopoly. We had a 100 per cent market share 20 years ago and today we have less than 1 per cent of the market share of all communication," Fahour said. "Where did the other 99 per cent go? It has gone to digital communication."
DPA's Randy Dean is happy to stand in Fahour's way. "The internet history museum is filled with the fossils of many companies that not only did not thrive but did not survive the digital transformation of their businesses [including] Kodak, Border books, Virgin Megastore and the like," he said.
Late last month Australia Post "launched" its service with Communications Minister Stephen Conroy and revealed it was being supported by several large companies including Telstra, AMP, Westpac, ANZ, Bendigo and Adelaide Bank, Link Market Services, NAB and Yarra Valley Water.
Being a government-owned organisation has also allowed Australia Post to partner with the Australian Tax Office and the Department of Human Services, both of which are exploring how to use the service to communicate with citizens about government services.
"This group of mailers that have partnered with Australia Post represents more than 70 per cent of the mail volume for Australia's top 10 mailers," Fahour said.
DPA disputes Fahour's claim but refuses to say who its partners are or even how many it has signed up.
It claims its joint venture partners Computershare and Salmat BPO (now owned by Fuji Xerox) already store, manage and print more than 75 per cent of all essential mail in Australia.
"Australia Post's sole relationship with that mail is picking it up in pre-sorted boxes and sending it out on trucks for delivery," it said.
DPA is using technology from US digital mailbox provider Zumbox to power its back-end, while Australia Post is using technology from Volly, which has delayed the launch of its technology from January 2011 to some time next year.
DPA believes it will launch its full digital mailbox service first, locking in a February 2013 date.
"Despite what Mr Fahour would like the market to believe, this business is about delivering, not announcing," DPA said.
"Judging from their many recent technical mishaps, including the failure of their Digital Mailbox pre-sign-up form, Australia Post is discovering that it is much more difficult to deliver reliable digital services than to talk about them in the press."
As for junk mail, Dean said there would be a marketing component to DPA but these messages would be separated from the user's main box and individual providers could be blocked at any time.
- Sydney Morning Herald
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Do you check your smartphone in bed?Related story: Smartphone etiquette - should you take it to bed?


text:
Andrew McDonald
MP, Middlesbrough
MP, Middlesbrough
See our much more detailed, easier-to-read analysis of votes on health, welfare, foreign policy, social issues, taxation and more.
Andrew McDonald never rebelled against their party in this parliament
The Minister is making a powerful case and I agree with all he is saying, but before he moves off education, I wonder whether he will help me to reconcile his strong attitude in favour of assisting disabled people overseas with recent UK domestic pronouncements about the disabled students allowance. A completely different message is being sent about our support for people who need access to...
That was a very nice attempt at a smear. Will the hon. Gentleman say where that was published and where the information is, and how about naming some names? He cannot just cast that out on to the water as if it were true.
Does my hon. Friend agree that putting people in that position limits their ability to be economically engaged, because they cannot plan or apply for mortgages and all the rest of it? That might be to the benefit of the exploitative employer, but it does nothing to help the economy or people by giving them security of employment.
More of Andrew McDonald's recent appearancesRSS feed (?)
Labour MP for Middlesbrough
Entered House of Commons on 30 November 2012 — Byelection
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Today, Responsible Care is practiced in over 50 countries and seeks to align with society's expectations and aspirations for economic, social and environmental sustainability.
We support the original 1987 United Nations Brundtland Commission definition which describes sustainability as the ability to develop in ways that meet the needs of the present without compromising the ability of future generations to meet their own needs. We also support the triple bottom line (TBL) approach that balances economic, social and environment considerations for actions and decisions.
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Mohawk BriteHue - A7 Envelopes - SEA BLUE - 250 PK
Write a review | No reviews for this product.
Write a review | No reviews for this product.
Mohawk BriteHue ENVELOPES
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Mohawk BriteHue inspires great design. Your project is sure to get noticed with this vibrant saturated color scheme. The paper features a full spectrum of vivid colors and stock offerings of cut sheets and envelopes. Manufactured responsibly by Mohawk paper mills.View all Britehue Products or all Mohawk Brands
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SwitchEasy rolls out Colors for iPhone 3G
SwitchEasy has announced the release of its new Colors case for the iPhone 3G. Made from silicone, Colors is a form-fitting case featuring a "jelly bean" home button, thick silicone for shock protection, and extra-thick button covers for the volume and power buttons. Each Colors case includes a case, two anti-static screen protectors, a Microfiber cleaning cloth, a squeegee applicator, a headphone jack protector, and a 30-pin Dock Connector protector. As its name would suggest, Colors is available in 10 different colors, and is available now for $15.
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These guys rock!
I'm sick of so-so $30+ silicone cases.
Their customer service is fantastic!
I'm sold on this company.
Others take note - no more overpriced mediocre cases.
Posted by slb on August 12, 2008 at 2:26 PM (CDT)
considering you can only get 3 screen protectors at the same price, $15 is a great price for all these.
Now if only we can have a quick review :)
Posted by Ben on August 12, 2008 at 2:30 PM (CDT)
I bought the REBEL CELESTIAL from them and I can't wait to get it.
They seem very eager to get some market share, and I'm going to help if it's as good as it looks online.
Posted by slb on August 12, 2008 at 3:47 PM (CDT)
just ordered the Colors Truffle. Was going to get the incase but that was going to be over $30 for a silicon case. Looking fwd to this case!
Posted by golby on August 12, 2008 at 6:36 PM (CDT)
I just got the CapsuleRebel in Black and Arctic for my iPhone 3G and I have to say, this is the best case I've ever had! I used to like iSkin's products, but their recent designs only hide Apple's original design. Definitely spread the word about SwitchEasy!
Posted by Adam on August 12, 2008 at 6:40 PM (CDT)
I have the CapsuleRebel in black and i LOVE IT!!!! I have ordered the Colors case in Mican for when I'm in a different mood.. LOL…
These cases are great!!! And so reasonably priced. They are certainly the gold standard as far as I am concerned. SPREAD THE WORD!!!!!
Posted by Chris on August 13, 2008 at 9:36 PM (CDT)
You guys have to be kidding me. You guys post like your paid forum lurkers on SwitchEasy's payroll?
Posted by Addison Cecilia on August 15, 2008 at 2:34 AM (CDT)
Cecilia frankly their cases are pretty decent, well thought out, and their price is almost unbeatable.
similar cases would easily cost you over $25 elsewhere.
Posted by Ben on August 15, 2008 at 12:22 PM (CDT)
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Town Square
Menlo Park: Big rig loses load on Sand Hill Road
Original post made on Dec 11, 2013
Read the full story here Web Link posted Wednesday, December 11, 2013, 8:16 AM
Comments (1)
a resident of another community
on Dec 11, 2013 at 10:23 am
I lost a friend in an accident when a logging truck lost its load.
Thank goodness no one was injured . Was there damage?
Why does your article not name the trucking company?
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And you shoot in ways that you could never set up on your own. Out of a car window, under low cover, standing on one leg while juggling 3 oranges--you name it, we put 'em through it. It's good practice.
This is a discussion on IDPA or USPSA ? within the General Firearm Discussion forums, part of the Related Topics category; And you shoot in ways that you could never set up on your own. Out of a car window, under low cover, standing on one ...
And you shoot in ways that you could never set up on your own. Out of a car window, under low cover, standing on one leg while juggling 3 oranges--you name it, we put 'em through it. It's good practice.
"What does Marcellus Wallace LOOK like?"
Look, it was fun, but I carry in a crossdraw when in the car, and at about 5 o'clock in a "palm out" configuration when I'm not sitting for long times. I prefer to use lasers, ghost ring or slide mounted red dot set ups since my eyes won't focus on the front sights anymore in a standard sight set up. I don't understand the restrictions on reloading on the move or shooting on the move, so long as I'm not violating a safety rule. And I found it hard to be competitive with a single stack 9mm, so I was using a double stack. I the rest of my issues with IDPA were RO personalities and range issues, which you can encounter everywhere.
Okay--here we go: Lasers and ghost rings are illegal--notch and post sights only. Now, you could do USPSA Open Division, but that's where the big sharks swim. The rules state that all reloads must be conducted--started and finished--from cover when available. Good rule. There is no restriction in the rules on shooting while moving, but the individual course of fire may have some prohibition on it. it is to be discouraged, and shooting on themove is to be encouraged (in the rules).
IDPA is ubjective with respect to the SO, that's true. A bad SO can ruin a stage, and a good one can make a stinky stage pretty fun.
"What does Marcellus Wallace LOOK like?"
I've been shooting IDPA since 2007; that addendum has had the practical effect of almost eliminating shooting on the move from most IDPA matches (at least those that strictly follow IDPA course design guidelines).
When it comes down to it, any shooting sport is a game and when you play a game you agree to abide by the rules (or, at least, quietly accept whatever penalties accrue for choosing not to follow the rules). The biggest ongoing issue I have with IDPA is, in fact, the subjectivity of an SO's calls. You could have identical barricades on two different stages, approach them the same way, and one SO will say nothing while another will give you a cover call PE. That really frosts my cookies. And don't get me started on how penalties are assessed (or, I should say, not assessed) against the top level shooters at big matches as opposed to "regular" shooters. Also, I've seen more than my fair share of "homer" syndrome, where the local shooters for a club hosting a big match get a free ride on stuff that everybody else gets penalized for.
Mind you, I still shoot IDPA and I am in fact going to shoot the S&W Indoor Nationals this weekend. I have just resigned myself to having to accept some of these issues as the price of getting trigger time in this sport. I now vastly prefer USPSA because it lets you figure out your own way to shoot the stages, all the rules-lawyering is generally done off-line and is restricted to equipment enforcement, and you can be reasonably certain that once the buzzer goes off the calls will be consistent. Just my two cents, coming from somebody who has shot a fair amount of both.
What is a moderate interpretation of [the Constitution]? Halfway between what it says and [...] what you want it to say? Justice Antonin Scalia
SIG: P220R SS Elite SAO, P220R SAO, P220R Carry, P226R Navy, P226, P239/.40S&W, P2022/.40S&W; GSR 5", P6.
To the OP... you can shoot USPSA however you want essentially, without penalty. IDPA, not so much. Shoot both and don't believe everything you read on the net. I moved to uspsa because I got really bored with IDPA and it's constant scripted course of fire. Nothinng wrong with shooting your carry gear in uspsa. There is likely a division it will fit in.
Kazz: don't get me started on cover calls and horse apple rulings.