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Disclosed is a method for the chemical synthesis of deoxypyridinoline (DPD). The synthesis involves the preparation of a protected 3-hydroxypyridinium starting with a Nα-protected lysine and a 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate with subsequent deprotection to provide the desired DPD.
1. A method for the preparation of deoxypyridinoline which comprises the steps of:
(a) reacting an Nα-protected-O-protected lysine of the formula: ##STR3## with at least two equivalents of 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate of the formula: ##STR4## to produce the corresponding aminodiol of the formula: ##STR5## b) reacting the aminodiol with an oxidizing agent to provide the corresponding aminodiketone of the formula: ##STR6## c) reacting the aminodiketone with a base to produce the corresponding 3-hydroxydihydropyridine and then reacting the 3-hydroxydihydropyridine with an oxidizing agent to form the 3-hydroxypyridinium ring thereby providing a compound of the formula: ##STR7## and d) deprotecting the compound of step (d) to provide deoxypyridinium of the formula: ##STR8##
2. The method of claim 1 wherein all of the intermediate products are recovered and purified with the exception of the aminodiketone.
3. A method for the preparation of deoxypyridinoline which comprises the steps of:
a) Reacting at least two equivalents of N-CBZ-2-amino-5,6-epoxy-hexanoate-5-t-butyl ester in an appropriate solvent with Nα-CBZ-O-t-butyl L-lysine to provide 2,12-benzyloxycarbonylamino-7-(5-benzyloxycarbonylamino-5-t-butoxycarbonylpentyl)aza-1,13-di-t-butyl-5,9-dihydroxy-tridecanoate and recovering this diol;
b) reacting the diol prepared in step (a) with a suitable oxidizing agent in an appropriate solvent to provide 2,12-benzyloxycarbonylamino-7-(5-benzylcarbonylamino-5-t-butoxycarbonyl-pentyl)aza-1,13-di-t-butyl-5,9-dioxo-tridecanodoate, and
c) without its isolation, reacting the tridecanoate with a base to provide 3-hydroxy-1-(5-benzoxycarbonylamino-5-t-butoxycarbonyl-pentyl)-4-(2-benzyloxycarbonylamino-2-t-butoxycarbonyl-ethyl)-5-(3-benzyloxycarbonylamino-3-butoxycarbonylpropyl) pyridinium salt; and
d) reacting the pyridinium salt prepared in step (c) with HBr in an appropriate solvent to provide deoxypyridinoline.
4. The method of claim 3 wherein the reaction of step (a) is carried out in acetonitrile, methanol or a combination of water and alcohol as solvent.
5. The method of claim 3 wherein lithium perchlorate is included in step (a) as a catalyst and acetonitrile as the solvent.
6. The method of claim 3 wherein the oxidizing agent in step (b) is oxalyl chloride-DMSO, thionyl chloride-DMSO, trifluoroacetic anhydride-DMSO or acetic anhydride-DMSO.
7. The method of claim 6 wherein the oxidizing agent is oxalyl chloride-DMSO.
8. The method of claim 3 wherein the solvent in step (b) is methylene chloride, diethyl ether, tetrahydrofuran or chloroform.
9. The method of claim 3 wherein the base in step (c) is triethylamine.
10. A method for the preparation of deoxypyridinoline which involves
a) reacting an Nα-protected-O-protected lysine with at least two equivalents of 5,6-epoxy-2-N-protected-O-protected (2S)-2-aminohexanoate in an appropriate solvent to produce the corresponding aminodiol;
b) reacting the amino diol with an oxidizing agent to provide the corresponding aminodiketone;
c) reacting the aminodiketone with a base to produce the corresponding 3-hydroxydihydropyridinoline compound as an intermediate and then reacting this intermediate with an oxidizing agent to form the corresponding pyridinium compound; and
d) deprotecting the pyridinium compound to provide deoxypyridinoline.
Collagen is present in various forms in all tissue. It is now well accepted that collagen has the form of amino acid chains cross-linked by pyridinium cross-links. The pyridinium crosslinks are formed from three hydroxylysine residues, two of which are from the terminal (non-helical) peptides of the collagen molecule that are enzymatically converted to aldehydes before reaction and a third hydroxylysine situated in the helical portion of a neighboring collagen molecule. Two pyridinium crosslinks, pyridinoline (PYD) and deoxypyridinoline (DPD), have been identified. There have been described in the literature techniques for the measurement of pyridinoline in urine by use of enzyme labeled anti-PYD to form a pyridinoline-enzyme labeled complex which can be detected by an enzyme-linked immunosorbant assay. While the analysis for PYD is useful as a means of screening for osteoporosis and rheumatoid arthritis, its presence in connective tissue, as well as in bone, can cause skewed results for the diagnosis of osteoporosis or bone degradation. Accordingly, immunoassays for deoxypyridinoline (DPD), which is only found in bone, have become preferred over those for PYD for the early detection of bone degradation.
Testing for DPD can be carried out by contacting a fluid test sample, e.g. urine, with a labeled antibody specific for DPD. A particularly convenient method for DPD analysis involves the use of a test strip of the type depicted in FIG. 1. Referring to FIG. 1, strip 10 having a labeled anti-DPD antibody complex (typically with gold sol as the labeling material to provide a gold sol-DPD antibody complex) binds with DPD in the fluid test sample applied to the application zone 12 of the strip 10 and migrates through the first capture zone 14 and second capture zone 16. In the first capture zone 14 there is immobilized DPD which captures unbound, labeled anti-DPD. The labeled antibody, which was not captured in the first capture zone because it combined with DPD in the fluid test sample, is captured in the second capture zone 16 by anti-DPD antibodies which are immobilized in this zone. The DPD concentration in the test sample can be determined by spectrophotometrically measuring the amount of labeled DPD captured in the first capture zone 14, or more accurately by use of an algorithmic treatment of reflectance measurements from both zones 14 and 16.
The first capture zone 12 requires immobilized DPD with which the labeled anti-DPD, which hasn't reacted with DPD in the fluid sample, can combine to become immobilized in this capture zone. This sort of disposable test system requires the use of considerable amounts of DPD which, when obtained from animal bone, is quite expensive. The expense involved with the procurement of natural DPD has led to attempts to synthesize this material and thereby reduce the cost of diagnostic test strips which employ DPD in DPD detection systems.
One method for the synthesis of DPD as well as PYD and derivatives thereof is disclosed in published European Patent Application 0 556 152 A1. In this procedure a compound of the formula: ##STR1## is reacted with an R group which is defined as X5 --CH2 --CHX1 --Z--R3 wherein the R, X, Y and Z groups are selected to provide DPD, PYD or various derivatives thereof. In each case, the pyridine ring is formed before the addition of the side chain to the nitrogen atom. In the process for the preparation of DPD of the present invention fewer steps are involved because it is not necessary to separately prepare X5 --CH2 --CHX1 --Z--R3 thereby providing a less labor intensive method.
The synthesis of DPD contemplated by the present invention involves the steps of:
a) reacting a Nα-protected-O-protected lysine (compound 1, Scheme 1) with at least two equivalents of 5,6-epoxy-2-N-protected-O-protected(2S)-2-amino-hexanoate (compound 5, scheme 1) in an appropriate solvent to produce the corresponding aminodiol (compound 6, scheme 1). Suitable solvents include acetonitrile, methanol and water/alcohol. In Scheme 1, there is depicted lithium perchlorate as an additive which is provided for the purpose of catalyzing the reaction. Two equivalents of the epoxide per equivalent of the aminohexanoate are required because dialkylation is the required process.
b) The aminodiol 6 is then oxidized with a suitable oxidizing agent, such as oxalyl chloride-DMSO in a suitable solvent such as methylene chloride to provide the corresponding aminodiketone (compound 7, scheme 1). Suitable oxidizing agents other than oxalyl chloride-DMSO include thionyl chloride-DMSO, trifluoroacetic anhydride-DMSO and acetic anhydride-DMSO. Suitable solvents, other than methylene chloride include diethyl ether, tetrahydrofuran and chloroform.
c) The aminodiketone of step (b) is further reacted with a base such as sodium hydroxide in alcohol or a tertiary amine, e.g. triethylamine to produce the 3-hydroxydihydropyridine which is combined with an oxidizing agent such as the base (DBN) in the presence of O2 in a suitable solvent such as methylene chloride to form the 3-hydroxypyridine ring to provide pyridinium product 8 in scheme 1. Other suitable oxidizing agents include dicyanodichloroquinone (DDQ), bromine or MnO2 whereas the reaction can be carried out in other solvents, such as methylene chloride, acetic acid or methanol. Product 8 is deprotected to provide deoxypyridinoline. ##STR2##
The present invention is further illustrated by the following example.
A mixture of 25 g of Nα-CBZ-L-lysine from Sigma, where CBZ is benzyloxycarbonyl, 250 mL of t-butyl acetate and 14 mL of 70% perchloric acid was vigorously mixed until all solids were dissolved. After stirring overnight, 375 mL of ethyl acetate was added followed by 250 mL of water. The pH of the aqueous layer was raised to 5.5 with 20% NaOH whereupon the organic phase was separated. The aqueous phase was extracted with the ethyl acetate solution and the pH again raised to 10.5 whereupon it was again extracted with 200 mL of fresh ethyl acetate. The organic extracts were combined, washed with saturated brine, dried over Na2 SO4 and concentrated. The residue was dried overnight under high vacuum to yield 23.2 g of a colorless, viscous material.
1 HNMR (60 Mhz, CDCl3)δ: 7.35 (s,5H), 5.1 (s,2H), 4.2 (m, 1H), 3.1 (m,2H) 1.4 (s,9H), 2.1-1.4 (m,4H).
A mixture consisting of 3.7 (27.2 mmol) of ZnCl2, 3.2 g (53 mmol) of NaCNBH3 and 60 mL of methanol was prepared to which was added a solution of 18 g (51.7 mmol) of the amine 1 in 180 mL of methanol. After cooling to 10�-15� C. 12.4 mL of 37% formaldehyde (165 mmol) was added dropwise over a 2-3 minute period. The reaction was stirred for 1 hour and monitored by silica gel TLC with elution using a 60:10:1(v/v/v/) mixture of chloroform/methanol/concentrated ammonia (solvent A). One hundred milliliters of water was added and the mixture concentrated to a volume of 200 ml. Ethyl acetate (200 mL) was added and the pH raised to 10.5 with 10% NaOH. The ethyl acetate was separated and the pH of the aqueous phase readjusted to 10.5 and extracted with 200 mL of fresh ethyl acetate. The ethyl acetate extracts were combined, washed with NaCl, dried over Na2 SO4, filtered and concentrated to yield, after drying overnight under high vacuum, 14.86 g of viscous oil.
1 HNMR (300 Mhz, d6 DMSO) δ: 7.56(d,1H), 7.35(s,5H), 5.05(s,2H), 3.85(m,1H), 2.15(t,2H), 2.08(s,6H) 1.60(d of t,2H), 1.40(s,9H), 1.35 (m,4H).
A solution of 25.3 g of dimethylamine 2, 7.9 mL of 30% hydrogen peroxide and 150 mL of methanol was stirred for 5 h after which an additional 7.9 g of 30% hydrogen peroxide was added. The reaction was allowed to stir for 48 h and monitored by silica gel TLC, eluting with solvent A. A 1 mL aqueous slurry of approximately 5 mg of platinum black was added whereupon the reaction was stirred for 7 h and another slurry of 5-10 mg platinum black added. The mixture was stirred overnight and monitored for peroxides using peroxide test paper with warming to 60� C. to remove peroxides when necessary. Once the reaction tested negative for peroxides, the mixture was filtered and concentrated. The residue was dissolved into 300 mL of EtOAc, dried over Na2 SO4, filtered, concentrated and chromatographed on 400 g of silica gel, eluting with Solvent A to produce 13 g of product as a colorless oil.
1 HNMR (300 Mhz, d6 DMSO)δ: 7.78(d,1H), 7.37(s,5H), 5.05(dd,2H), 2.88(m, 1H) 3.05(t,2H,) 2.95(s,6H) 1.70(m,4H), 1.40(s,9H) 1.32(m,2H).
The synthesis of this Nα-protected-O-protected lysine is known in the literature (Scott et al, Commun., 1981, 11(4) 303-314.
A solution of 14.8 g of N-oxide 3 in 250 mL of DMSO was warmed to 125� C. for 2 h while sparging with argon. The DMSO was distilled at 70� C. under high vacuum. Chromatography of the residue on 450 mL of silica gel, eluting with 20:80 (v/v) of EtOAc/hexane, produced the product in fractions 70-120 (18 mL fractions). These were combined and concentrated to yield 3.15 g of the product as a colorless oil.
1 HNMR (d6 DMSO) δ: 7.62(d,1H) 7.35(s,5H) 5.78(m, 1H), 5.08(dd,2H), 4.98(m,2H) 3.86(m, 1H) 2.08(dt,2H) 1.68(m,2H), 1.38(s,9H) 1.35(m,2H).
The 85% m-chloroperbenzoic acid (mCpBA) from Aldrich Chemical Co. was purified by dissolving in methylene chloride and washing with pH 7.5 buffer. The organic layer was separated, dried over Na2 SO4, filtered and concentrated. The solid was dried overnight under high vacuum and stored at 3� C.
A mixture of 3.15 g of the hexanoate 4 (9.75 mmol) and 1.76 g of mCpBA, (10.2 mmol) in 25 mL of methylene chloride was stirred for 48 h at room temperature. The reaction was diluted with 125 mL of EtOAc and washed twice with 5% NaOH and then brine. After drying over Na2 SO4, the reaction was filtered and concentrated to produce 2.9 g of the product as a colorless oil.
1 HNMR (d6 DMSO) δ: 7.35(s,5H) 5.05(s.2H) 3.90(m, 1H), 2.65(m,1H) 2.50(m,1H) 2.42(m,1H) 1.8-1.5(m,2H) 1.40(s,9H) 1.35(m,2H).
MS(FAB): 358 (M+ +Na+)
Epoxide 5 (1.68 g, 5.01 mmol) was dissolved in 1.5 mL of dry acetonitrile after which 0.53 g (5.01 mmol) of anhydrous LiClO4 was added. When the solid dissolved 0.8 g (23 mmol) of amine 1 in 1.5 mL of acetonitrile was added. The mixture was stirred at 50� C. overnight and then concentrated under reduced pressure. The residue was chromatographed on 150 g of silica gel, eluting with 7:1 (v/v) chloroform/solvent A to produce 1 g of aminodiol 6 and 0.5 g of recovered epoxide. The diol was dissolved in a known amount of methylene chloride and stored over 3 Å molecular sieves for later use.
To 1 mL of methylene chloride was added 0.6 mL of 2M (1.2 mmol) oxalyl chloride in methylene chloride and the mixture cooled to -55� C. Dimethylsulfoxide (DMSO) (78 μL, 1.1 mmol) in 0.25 mL of methylene chloride was then added dropwise. After 15 minutes, 400 mg of the diol 6 in 1 ml of methylene chloride was added dropwise. The mixture was warmed to -30� C. while stirring for 20 minutes and the reaction was then cooled back to -55� C. whereupon 0.26 g (2.6 mmol) of triethylamine was added. The reaction was allowed to warm to room temperature and was then diluted with 25 mL of EtOAc, washed with 5% NaOH followed by brine and dried over Na2 SO4. After filtering, the solution was concentrated to yield 0.39 g of 2,12-benzyloxycarbonylamino-7-(5-benzyloxycarbonylamino-5-t-butoxycarbonyl-pentyl)aza-1,13-di-t-butyl-5,9-dioxo-tri-decanodiate 7 which was not characterized due to its instability. The residue was dissolved in 4 mL of methylene chloride and 0.25 g of diazabicyclo 4.3.0!non-5-ene (DBN) added. The mixture was stirred overnight protected by a drying tube. Acetic acid (100 μL) was added and the solvent evaporated. The residue was chromatographed on 100 g of silica gel eluting with 20:1:0.5 chloroform/methanol/acetic acid. Fractions 11-14 (18 mL fractions) contained 0.26 g of pyridinium product 8.
A mixture of 160 mg of the pyridinium acetate 8 and 1 mL HBr in HOAc was stirred for 30 minutes and then an additional 1 mL of HBr/HOAc was added. After 1 h the solvent was removed and the residue dissolved into 50 mL of a 4:1:1 (v/v/v) mixture of n-butanol/water/HOAc (solvent B) after which 5 g of fibrous cellulose was added. The suspension stood for 30 minutes and was filtered followed by the addition of 3 more grams of cellulose to the filtrate and additional filtering after 2 hours. The two cellulose solids were combined and slurried in 50 mL of water and filtered after 30 minutes. An aliquot was removed whose absorbance in pH 8 buffer at 326 nm using a 5290 molar extinction coefficient and molecular weight of 413 indicated 28 mg of DPD. The solution was lyophilized and the residue dissolved in 10 mmol HCl and 8 g of washed BioRad AG-1X10(Cl- form). After 1 h the resultant was filtered and the filtrate concentrated to dryness on a Savant Speed-Vac� concentrator to yield 56 mg of the very hygroscopic tetrachloride salt.
1 HNMR (300 Mhz d6 DMSO) δ: 8.65(s,1H), 8.50(s,1H), 4.51(t,2H, J=7.5) 4.28(t,1H,J=7) 4.10(t,1H,J=6) 3.99(t,1H,J=7) 3.4(m,2H) 3.2-2.9 (m,2H) 2.2(m,2H) 2.1(m,2H) 2.0(m,2H) 1.5-1.3(m,2H)
The O-t-butyl esters and CBZ protective groups may be removed by a variety of treatments familiar to one skilled in this art as described by Greene et al in Protective Groups in Organic Synthesis; John Wiley & Sons: New York, 1991:Pp 246 and 335-7. Thus, the t-butyl ester may be removed using other acids such as formic, hydrochloric, P-toluenesulfonic, trifluoromethanesulfonic, methanesulfonic and trifluoroacetic. The CBZ group may be removed by a variety of methods such as, for example; by hydrogenolysis, with Lewis acids such as aluminum chloride, trimethylsilyl iodide and boron tribromide; photolysis; electrolysis; barium hydroxide or by the use of other acids such as trifluorosulfonic acid and methanesulfonic acid.
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26th Annual Wildman BiathlonAugust 09, 2014
The Wildman Biathlon is a three-part running, bike, uphill run event for teams and individuals. Now in its 26th year, the Wildman is New England's toughest single day, multi-sport event, challenging individuals and 2 or 3 person teams who enjoy a variety of terrain and scenery.
T-shirts are offered to all participants with trophies awarded to overall and category winners along with the numerous prizes given away through random drawing. Funds raised from this event benefit the Coos County Retired and Senior Volunteer Program.
This event is planned, organized, and run by employees and volunteers of Tri-County Community Action Program Inc. For more information and to register for the event, visit the Wildman Biathlon Event Page.
Cans or Cash @ The CatNovember 29, 2014
We're hosting a jib session on Saturday, November 29 of Thanksgiving weekend. We're asking for three canned goods or $3 donation going toward a local food pantry. The ticket for the hike jib session will be separate from the ticket for lift-accessed terrain.
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FREE Learn2 Weekend - Space Limited, Call To Reserve Today!December 13, 2014
Know someone who should learn to ski or snowboard this season? We want to get them started, become their home mountain and share the Wildcat Mountain experience and it's FREE December 13 & 14!
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Torchlight ParadeFebruary 14, 2015
Starting around dusk a torchlight parade will flow down Upper Wildcat and Bobcat.
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Kitty Litter Cardboard Box RaceFebruary 17, 2015
A fun, free, February Vacation tradition for kids. Build your own "vessel" out of cardboard boxes and go head-to-head in a series of heats held at the base of Wildcat.
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Nine Lives Lunch Tray LugeFebruary 18, 2015
The one day a season we permit lunch tray luge at the mountain and another February Vacation tradition, test your speed on the "track" at the base of Wildcat in a series of head-to-head heats.
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12th Annual 100,000 Vertical Foot ChallengeMarch 09, 2015
A charity event that supports Make-A-Wish of New Hampshire, challenges skiers/riders to log a total of 48 runs on the Lynx Trail to achieve 100,000 vertical feet over the course of the day, non-stop. Pre-registration required.
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Wildcat Spring Pond SkimApril 11, 2015
The pond skim is back at Wildcat Mountain and we'll be looking to celebrate the late spring tradition. Skim or swim, someone is getting wet!
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Trinity Lutheran Church is a Reconciling in Christ Congregation. RIC congregations clearly state that they welcome people of all sexual orientation and gender identity. The pictures below are from our celebration of RIC status on July 13, 2014.
Welcome to Trinity!
No matter your faith journey or your past,
we welcome all with open arms.
Trinity Lutheran Church is centrally located in beautiful Ann Arbor, Michigan. We are a diverse community of people who share a common faith in Jesus Christ and seek to grow in the understanding of what that means for our lives each day. Trinity offers rich and varied worship opportunities and a full array of activities for all ages. Contact us today!
Current Offerings
Check out our 2014 Advent Calendar of activities!
Everyone is invited to the Advent Workshop and Brunch on Sunday, November 23 from 12:00-2:00p.m. in the Social Hall. Before we break for Thanksgiving, we want to be prepared for Advent! Plan to bring food (fruit, pastries and donuts, sausage links and patties, orange and apple juice) to share for the brunch as we gather together in fellowship. Our Bits & Bites Mission will prepare brunch casseroles. Naturally, we will have special music to keep things lively and lovely.
Our annual Advent Wreath Workshop will be incorporated into the activities. Watch for a new twist on this age-old tradition! We will also preview and distribute all of the materials for home devotionals for the upcoming Advent season that begins on November 30. Sunday School families will meet in the social hall for the entire education hour during all four weeks of Advent as we build our Jesse Trees, prepare for the family Christmas Eve service, and wait for Christ's coming. Don't miss this event!
Our Statement of Mission
Our purpose is to serve God by loving the world as God loves us.
Trinity continues a long tradition of social engagement and generous outreach in the vibrant programs we carry on today.
We invite you to join us in worship, education, and mission, with the hope that you will feel at home in our community of faith.
We want to connect with you online and in person so that you may find joy, peace, and purpose in the good news of God's love and grace.
Trinity is also home to the


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Blood Vessels Teacher Resources
Find Blood Vessels educational ideas and activities
Showing 1 - 20 of 577 resources
Blood Vessels
A series of diagrams and photographs is a vivid tool for delivering a lesson about blood vessels. Each slide has notes for the lecturer to use to explain each slide. Your young biologists will increase their understanding of the structure and function of arteries, veins, and capillaries.
9th - 12th Science
Can We Eat to Starve Cancer?
Is there an answer for cancer? Your AP biologists will be inspired by this lecture on how the foods that we eat stimulate or inhibit the growth of blood vessels, which in turn, bring health or disease to the human body. Research is showing that eating the right foods can prevent cancer.
21 mins 11th - Higher Ed Science CCSS: Adaptable
Anatomy Review: Blood Vessel Structure and Function
Compliment your unit on anatomy with this review sheet on blood vessel structure and function. Complete with colorful illustrations to label and study, this worksheet provides an overview of information for class members to read as well as a series of questions on the given material.
10th - 12th Science
Heart and Circulation: Pre- and Post-Assessments
Meant to be given both before and after a unit on the circulatory system, this assessment is a set of 15 multiple-choice questions. Middle schoolers are queried on what they know about the structure and function of the heart and blood vessels.
5th - 8th Science
The Circulatory System
A variety of animals' circulatory systems are compared to the human circulatory system. Paul Andersen uses his SMART Board to show the differences between two, three, and four chamber hearts, focusing on the human heart. Blood vessels and blood components are thoroughly discussed, as well as the cardiac cycle.
12 mins 9th - 12th Science
The Heart Stopper
Use the pump from a spray bottle to drive a model of the heart in action! In addition to modeling the function of the heart and blood vessels, aspiring anatomists also simulate arterial blockage. They compare the effects of increased heart rate and increased blockage size.
9th - 12th Science
What is Blood Pressure?
Find out how we describe the force created by the blood against the walls of the vessels in a heart-pumping lesson! As part of a unit on the heart and circulatory system, cardiology kids use a blood pressure monitor to find their systolic and diastolic pressures.
5th - 8th Science
The Circulatory System - Chapter 12 Worksheet & Reading Guide
An all-around circulation of the cardiovascular system, this worksheet will quiz your young biologists on how much they know. With written answers, they will explain the function and structure of the cardiovascular system. Even though this was created to support a specific textbook, you can simply remove the title and use it in any biology class when surveying human body systems.
7th - 10th Science
The Function of Villi in the Small Intestine
Ever wonder what the villi in the small intestine do? I bet your class would love to find out. Mesh netting is used to represent small blood vessels on the outside of the intestine, and a chenille bath mat is used to represent the villi inside the intestine.
7th - 9th Science
Fish Prints
What do a dead fish, conservation, and paint have in common? The answer is a great lesson about fish anatomy, fun print making techniques, and unsustainable fishing practices. The class will start by making fish prints with a deceased fish and paint, they will discuss the functions of each part of the fish's anatomy as they label their prints.
3rd - 5th Science CCSS: Adaptable
Elastic Recoil in Arteries and Veins
A lab in which high schoolers examine the difference between arteries and veins. Budding biologists will find out which blood vessel can stretch furthest, recording their data in a table then answering several questions evaluating their work and safety procedures.
9th - 12th Science
AP: Chapter 42: Circulation & Gas Exchange
Immerse biology learners in circulation and gas exchange for both simple organisms and higher animals. Six pages of short-answer questions and labelling of the human respiratory system are included. This assignment was written for an advanced placement biology course and zeroes in on the relationship between the circulatory and respiratory systems.
9th - Higher Ed Science
Blood Highways
Fifth graders read an informative paragraph about how blood travels through our bodies. Then, they fill in the missing letters for words that label things in the circulatory system. An answer key is provided on page two. An interesting, and easy-to-implement, science activity is described at the bottom of the page.
5th English Language Arts


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Find records of Nellie Ashleman
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text: A Short History Of Sharron Angle's Bigotry 2Irin Carmon and 153 others EditDelete InviteInvite manuallyPromoteXDismissXUndismissBlock for JezebelHide It's challenging to stand out as a bigoted crackpot this campaign season, but Sharron Angle deserves a gold star, says Rachel Maddow, for having the most "overtly racist" ad this year. Is she also the most bigoted major-party nominee? » 10/25/10 4:07pm 10/25/10 4:07pm


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Enrollment Keys
The enrolment key is a Moodle setting that any teacher or admin user can set on a course by course basis. Enrollment keys are required for all academic courses.
To locate and use this setting:
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- Northern Illinois to get $8.3 million for state construction projects
- Tree-lighting festival kicks off holiday season in Machesney Park
- Roscoe Boy Scout Troop's tree stand at new location
- Tips for selecting safe toys for kids this holiday season
- Prayer service for World AIDS Day Nov. 30
- Food Bank joins national #GivingTuesday movement
- Lee Hamilton: What lies ahead for Congress
- Rockford Public Schools faces $8.8 deficit, board OKs flat tax, HR chief
- Literary Hook: A holiday tradition: 'This Thanksgiving, Remember'
- Cold snap does not negate global warming
Raw Energy: The benefits of raw fats
By Brenda Richter
Your body needs fat, or at least the "good fats" (such as mono and polyunsaturated fats), to function properly. Minimizing and/or avoiding the "bad fats" (such as trans fats and saturated fats) is ideal.
Essential Fatty Acids (EFAs: a long-chain polyunsaturated fatty acid) are the only fats your body cannot produce on its own. EFAs help your cells repair and regenerate, receive nutrition and eliminate waste. They also help combat depression, low energy and stress while improving mental clarity and attention span.
EFAs have another perk! They also help reduce the visible signs of aging! EFAs may be found in nuts, seeds, cold-pressed seed oils and hemp-based products, (oil, protein and seed).
The good, natural fats (think of avocados and flax seed oil) are very sensitive to heat, and are easily damaged by it. Heated fats have lost their antioxidant qualities, and are known to be carcinogenic. Heating fats also makes them sticky, which can cause blockages in the arteries and digestive tract, inhibit the absorption of nutrients, and reduce the body's ability to transport oxygen. If you eat plenty of fresh green vegetables and fruits, you don't have to worry much about eating a moderate amount of the good fats. A great way to incorporate this into your diet is in salad dressings…ones you make at home are ideal!
Want variety and recipe ideas? Want to learn more about raw foods and the benefits? Listen to an upcoming "Why Raw?" talk. Limited seating and pre-registration required for the following talks: Oct. 16, 9:30 a.m., Choices Natural Market, 6551 E. Riverside, Rockford; and Oct. 16, 3 p.m., Bushel N Pecks, 328 State St., Beloit, Wis. Cost is free, although a $5 donation is much appreciated. Contact firstname.lastname@example.com or call (815) 543-1207 to pre-register. Visit myrawenergy.com for more information.
Brenda Richter is a graduate of Living Light Culinary Arts Institute, where she received her certification as a Raw Culinary Arts associate chef and instructor. She's passionate about sharing the living foods lifestyle with others, and teaches raw culinary arts classes in the Rockford area.
From the Oct. 13-19, 2010 issue


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Lafayete, LA, United States | Member Since 2011
"This book was so captivating."
I loved how descriptive this story was. It was also very real, it wasn't sensationalized or exaggerated. I could place myself in the seasons of the story, and I found myself longing for a farm of my own.
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In Easy Thai Cooking, we bring you Thai food as it's eaten in the countless restaurants of central Thai cuisine found in and around Bangkok.
Though this cookbook is in every way authentic to Thai cuisine, we've presented Thailand's favorite foods without fuss and in a way that anyone can make.
This cookbook guides you through an endless variety of multi-dish dinner parties and it also gives you quick everyday meals that will breathe new life into your kitchen.
To help you shop, our ingredients list will show you what those items look like as they're likely to be found in Asian markets. We've more...
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Lindsay Lohan to Star in Elizabeth Taylor Biopic?by Free Britney at . Comments
Lindsay Lohan is in "early talks" to play Elizabeth Taylor in the Lifetime movie "Elizabeth & Richard: A Love Story," according to Entertainment Weekly.
Who better to play the a glamorous Hollywood icon than a train wreck frequent jailbird Playboy model who hasn't had a notable acting role in years!
The film will focus on Taylor's tumultuous relationship with two-time husband Richard Burton. So how on Earth did they think of Lohan for the part?
Like Lohan, Taylor began her career at a young age, growing up in the spotlight. Some say she made plenty of missteps along her road to icon status.
Lohan also posed for Marilyn Monroe-inspired Playboy photos which allegedly racked up record sales for the mag, resurrecting her career somewhat.
Maybe a Liz T. photo spread is next? Eh, maybe not.
Elizabeth Taylor passed away in March at age 79.
[Photo: WENN.com]
Why give this actress that role, she doesn't have the class Elizabeth had... Why!!! This girl needs to worry about putting her life back together before trying to make a comeback. I am for one not going to watch her make elizabeth look bad. Yes, I agree she has her cheekbones but thats it.
I know she messed but I'm still rooting for Lindsey to get this part and get it together!!!! In this pic, with the exception of the blonde hair, they kind of favor. She could do it ;)!


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All Schools
(8) All Schools
(8) High Schools
(7) High Schools
(7) Elementary Schools
(7) Elementary Schools
(7) Preschools
(5) Preschools
(8) All Schools
(8) High Schools
(7) High Schools
(7) Elementary Schools
(7) Elementary Schools
(7) Preschools
(5) Preschools
There are 8 private schools located in Nevada that offer Softball as an interscholastic sport.
Softball Private Schools
- School Location Students Grades
Henderson Lake Mead Christian Academy
540 E Lake Mead Parkway
Henderson, NV, 89015
(702)565-5831(Christian)552 students | Gr. NS-12
RenoBishop Manogue Catholic High School
110 Bishop Manogue Drive
Reno, NV, 89511
(775)336-6000(Roman Catholic)649 students | Gr. 9-12
Las VegasCalvary Chapel Christian School
7175 W Oquendo Rd
Las Vegas, NV, 89113
(702)248-8879(Christian)555 students | Gr. PK-12
SparksExcel Christian School
850 Baring Blvd.
Sparks, NV, 89434
(775)356-9995(Christian)295 students | Gr. PK-12
Las VegasFaith Lutheran Middle School & High School
2015 S Hualapai Way
Las Vegas, NV, 89117
(702)804-4400(Lutheran Church -- Missouri Synod)1462 students | Gr. 6-12
Las VegasMountain View Christian Schools
3900 E Bonanza Rd
Las Vegas, NV, 89110
(702)452-1300(Christian)402 students | Gr. PK-12
Las VegasSt. Francis De Sales School
1111 N Michael Way
Las Vegas, NV, 89108
(702)647-2828(Roman Catholic)300 students | Gr. K-8
Las VegasThe Meadows School
8601 Scholar Lane
Las Vegas, NV, 89128
(702)254-1610790 students | Gr. PK-12
State Statistics
|About This State (NV)
|(NV) State Statistics
|Nationwide Statistics
|Population (Approximate)
|2,344,858 people
|304,788,332 people
|Age 25+ w/College Degree
|Median Household Income
Recent Articles
Updated October 26, 2014
What do you do when you are dissatisfied with your local public schools? Homeschool your children? Send them to private school? Let's look at your options.
Your religion matters to you. You want your child to attend a school which will combine academics and religious education. Here is an overview of what is available together with some links to denominational web sites.
Add things up and you'll quickly find the answer- math is crucial both in academics and the real world. By following these strategies and following personal training programs, students can uncover their weaknesses and conquer math.


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A book by Donald Miller< read all 9 reviews
Donald Miller does an excellent job in this book of communicating Christianity as a relevant, recognizable, and practical faith that, when viewed in such a manner, can have real change and impact in lives. Miller strikes me primarily in this book as extremely honest. He consistently admits to the hard aspects of Christianity that are not easy to understand or to obey. This book is written in very accessible language for today's generation, and thus is a very informative and interesting read for anyone who is skeptical about Christianity. It paints the picture as it is, asking questions such as why Christians don't appear different than non-Christians.
Overall, this book proclaims the fact that Christianity is not merely mental acceptance of a certain set of beliefs about Jesus and God. When actually practiced, Christianity is a lifestyle that involves loving people for other reason than that God loves people. Christianity is the overflow of a one's heart that is so filled with gratitude, knowing that God loves him/her, that he or she can't help but show love to other people. This is the type of "Christian spirituality," as Miller puts it, that can bring about not only real change and social progress, but real moral and spiritual revival because of Jesus's sacrifice for all who believe in Him.
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By Kevin Unitt 04/04 Updated: 05/04 11:07
BUS fares will rise by another five per cent across Warwickshire from next week with operators laying the blame on the government.
Adult fares will rise by between 5p and 30p, with day rider tickets in Warwick district rising 20p to £4.40.
A seven-day megarider ticket also rises 65p to £13.85 and a dayrider Gold ticket by 40p to £7.90.
Stagecoach Midlands blamed the rises on the government's 20 per cent cut in Bus Service Operators Grant from April 1, combined with the planned 3p fuel duty rise.
Managing director Steve Burd, said: "These damaging government cuts and tax hike, combined with rising costs, are having a direct impact on bus fares and services
"We share the frustration of our passengers, some of whom are on low incomes. Along with businesses, they are already being squeezed by higher bills and energy prices.
"We have had to take some very tough decisions, but we have worked hard to keep fares down for those who rely on the bus the most."
Visit www.stagecoachbus.com for further information on fares and services.
1 Pensioner dies after suspected argument with youths
2 Body found after search for missing man in River Leam
3 Two Leamington men jailed for raping escort
4 Stephen Fry, Boy George, Gok Wan and more love Warwick Rowers
THE "CHAINSAW massacre" of trees on Kenilworth Common
A SINGLE mother from Leamington has battled beyond
COMPUTER gamers in Leamington are taking part in
VANDALS who ran amok in a Cubbington churchyard
A MAN from Stratford who raped a prostitute twice as ...
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TWO men from Coventry have been arrested on suspicion of ...
AN OUTBREAK of norovirus has forced a ward to close ...


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Dear Kolter Families,
It is HERE! The Book Fair starts this week. Remember that all proceeds from the book fair go towards the library. Here is a schedule of events and hours of operation:
Monday, 11/17 at 5:30pm – Book Fair Kick-off and Family Dinner Night
Tuesday, 11/18 7:20am – 3:30pm
Wednesday, 11/19 7:20am – 1:00pm
Thursday, 11/20 7:20am – 1:00pm
Friday, 11/21 7:20am – 3:30pm
Our annual Kolter Fall FIESTA Gala & Auction was a huge success. We raised over $44K for Kolter! For those of you who were unable to attend the FIESTA, we have one last chance for you to get in on the fun. Below we have listed the teacher treasures and kids/adults socials that still have room for more participants. All spots are $20 unless otherwise indicated. Please email email@example.com with a list of social or treasures you wish to purchase by Wednesday, 11/19. We will confirm the availability and tell you the total amount due. Payment, by cash or check made payable to Kolter PTO, should be submitted to the front office. Here is what is available:
Teacher Treasures:
– Kinder sweet social: 12 remaining spots
– Sweet treat with first grade: 4 remaining spots
– Cooking with Ms. Garfinkel ($25): 2 remaining spots
– Third-grade pizza party ($35): 4 remaining spots
– Fifth-grade piece of the pie (shave Mr. Silk's head on the last day of school, $35):2 remaining spots
– Science special (Pond picnic and net fishing with Ms. Wood, $25): two remaining spots– Soccer
– Library game night: 8 remaining spots
– French snack on the Prairie: 1 remaining spot
- Soccer With Dr. Shetzer and Mr. Silk: 10 spots remaining.
- Kickball with teachers for third grade: 6 spots remaining
– Kickball with teachers for fourth grade: 2 spots remaining
– Kickball with teachers for fifth grade: 7 spots remaining
– Science museum and lunch with Ms. Kumari: 7 spots remaining
– Pizza and Henna with Ms. Kumari: 8 spots remaining
- Hot cocoa and cookies with Ms. Dickinson and Mr. Anderson: 8 spots remaining
Kids Socials(hosted by parents):
– Fifth-grade pool party: 5 remaining spots
– Third-grade pool party: 7 remaining spots
– Fourth-grade ice skating social: 11 remaining spots
– Second-grade girls pool party (at Maplewood): 3 remaining spots
– Second-grade boys pool party: 2 remaining spots
– First grade pool party: 9 remaining spots
– Kindergarten girls party: 9 remaining spots
– Kindergarten boys social in the park: 17 remaining spots
– Flag football game for 3rd–5th graders: 18 remaining spots
– Flag football game for K – 2nd graders: 13 remaining spots
Adult socials:
– Wine and Dine couples dinner party at The Fingeret's home: 2 remaining spots ($35 each)
– Karaoke and cocktails couples party at The Conte's home: 17 remaining spots ($35 each)
– Cooking class at Urban Chef with Chara Gafford: 7 remaining spots. ($25 each)
– Women's self-defense: 17 spots remain ($30 each)
– Kindergarten mom's dinner: 4 remaining spots ($25 each)
Finally, you may purchase free dress days for Thursdays in January, February, March, and/or April. Each month is $20 and you must indicate WHICH MONTH(S) you wish to purchase. (For free dress on each Thursday of that month).
The Cougars Care Service Project benefiting Kolter Kids ended on Friday. We received lots of great items for our little Cougars. Thank you again, for your generosity Kolter Families. The next step is sorting and distributing the uniforms to those in need. If you would like to volunteer with distribution please email email@example.com
Have a great week!
With Cougar Pride,
Lorena Estrada
Kolter PTO President, 2014-2015


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Created: 03/24/2014 1:33 PM
By: Elizabeth Reed, KOB.com
The FBI is still looking for a man wanted in connection to a Christmas Day stabbing on the Navajo Nation.
Calvin Fuson, 43, is accused of stabbing a relative in the chest with a kitchen knife in Naschitti, N.M. The relative survived.
On Jan. 22, a federal arrest warrant was issued for Fuson after he was charged with assault with a dangerous weapon with the intent to do bodily harm.
The FBI describes Fuson as Native American, 6'10" tall and approximately 172 pounds. He has black hair, brown eyes and tattoos on both hands and his upper right arm.
At the time of the incident, Fuson was a resident of Gallup, N.M. He is considered armed and dangerous.
KOB welcomes a lively and courteous discussion as long as you follow the rules of conduct set forth in our Terms of Use. Comments are not pre-screened before they post. You agree that anything you post may be used, along with your name and profile picture, in accordance with our Privacy Policy and the license you have granted pursuant to our Terms of Use.
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|Police: one dead after shooting in Raton


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- SHAKE what your mother gave Ya! Turn heads with the #RumbaRuffles spaghetti tie bikini. The Ruffles collection was inspired by RUMBA & SALSA dancing. When you are swaying your HIPS from SIDE 2 SIDE, the ruffles accentuate your dance moves & Booty. Available in 7 Tropical Colors. Link in Bio.
- G I R L C R U S H @madisonbmurray Rockin' @mynicolita RUMBA RUFFLES Palm #bikini on the beaches of Miami. Did you know that @madisonbmurray Walked the RUNWAY for #NicolitaSwimwear at MBFW and was one of our Booty Detectives?
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Monthly Archives: February 2013
Our Nicolita BoyShorts provide more coverage on your HIPS and THIGHS but still gives you a 'cheeky backside' cut.They feature our NO PINCH-FIT elastic around the hips and Heart-Shaped Backside! #swimsuit #nopinchfit
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BoyShorts are back on mynicolita.com by POPULAR demand!8 Tropical Colors to choose from. #swimwear #nicolita #NOPinchFit #CubanStyle
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A little #gavina cafecito to get Monday started right. @mgavina who needs a refill? #cafe #cubano
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Check out our amazing @mynicolita model @angelinakeala featured in fashionclimax.com Trend report. #mbfw #2013Collection #swimwear #sailorboy #retro #highwaist #sexy #nicolita
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Where is your 'Happy Place'? Somewhere when you close your eyes and you think of a special moment or time that transports your mind and puts a smile on your heart. A lot of my 'Happy Places' are on a beach and in a bikini..go figure. Here's one of them, the island of Formentera in the Mediterranean Sea. This is one of the most beautiful places I've ever seen. 12 miles of Crystal clear teal WARM water. #fbf #swimwear #smileitsFriday #nicolita #bikini
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Some #VDay Love for you… 15 Styles Under $30. Check out www.mynicolita.com Sale page for the new styles! XO
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Need a last minute Vday gift? Get your #1 Hot Mamacita a @mynicolita #swimsuit and work on your tan lines together…..or no tan lines is even better. :)XO #swimwear #sexy #vday #nicolita #tanlines
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Love IS in the air…literally! Paulina & @chrisgueits showing us how its done! @mynicolita #pinup #halter and #highwaisted #swimwear #bottoms #retro
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Fall in LOVE with our FIT! @mynicolita Valentine Sale starts today! Repost this image and TAG on twitter and Instagram @mynicolita or Nicolita Swimwear on Facebook to receive 20% off online code. Valid until Feb 14th.
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Sunday Funday Booty Workout. Anyone want to be my workout buddy?
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posted by Rebecca Keenan | 0 Comments
Our photo of the day was taken in Galway, Ireland. It shows the impressive interior of Galway Cathedral, one of Galway's top attractions.
For accommodation in Galway, look no further than our great selection of hostels in Galway. Watch our Galway video postcard and listen to our Galway podcasts to learn more about top Galway attractions from the Aran Islands to traditional Irish music.
In our hostelworld.com travel blog we bring you all the latest company news and information on new additions to the site including podcasts, videos and more. You'll also get inside information on a variety of destinations across the globe as they're visited by our travel editor and writers.
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Au 1195.22 $/oz
Pt 1225.00 $/oz
Oct 29, 1999
Web access through cellphones on wayBack
Africa|Screens|Siemens|Africa|Asia|South Africa|Communication Tools|Internet Browsing|Internet Connectivity|Internet Dial-up Subscribers|Internet Dial-upnSubscribers|Number Internet|Number Internet Users|Required Software|RequirednSoftware|Screen|Services|Wireless Applications|Gary Cousins|GarynCousins|World Cup|Cellular Telephone|WAP
© Reuse this The advent of wireless applications protocol (Wap), which will soon change cellphones from voice- transmission to data-transmission communication tools, is being regarded as the solution to bringing Internet connectivity to the mass market.
With the country's total number of Internet dial-up subscribers, or actual home-users, being a mere 558 000, it is clear there is a need to bring the Internet closer to home for many South Africans.
The reason for this low number of subscribers is evident: many people do not have access to the Internet at work or at home, while others simply cannot afford computers and the required software.
However, with about 2,4-million South Africans subscribing to cellphones, the groundwork has already been laid to take these masses into the next era, where a mobile phone is soon to become the only link between the user and the World Wide Web.
"The Wap solution is the key in providing interconnectivity to the mass market in places such as Africa and Asia, where cellular users far out number Internet users," says Gary Cousins of Siemens Information and Communication Networks.
"With the right handset, you will not need computer hardware for Internet browsing," he says.
A simple example that illustrates the practical implication of Wap is that everyone with a cellphone can now have an e-mail address, without the necessity of owning or having access to a computer.
Once a personal e-mail address is accessed, unread e-mail messages will be forwarded as text to the Wap-compatible cellphone.
The user will be able to reply to the sender by typing in a written message on the cellular handset.
"The cellular handset is used to dial into the Internet server via the wireless mark-up language, a specific language for wireless applications which allows the network operator to release Web information in a modified format, which is then displayed on the cellular handset," says Cousins.
However, the cellular handset will not be able to carry the Web-page format complete with pictures and special effects.
Information will be downloaded from the relevant site, and displayed almost like a stack of cards.
Once the user has identified a certain option, the screen will display the next set of options, until the relevant information has been downloaded in a brief and clear summarised format.
There will be no need to scroll down screens full of complicated inst ructions or irrelevant information, which saves the user cellular airtime.
To illustrate this, one can, for example, dial into the World Cup Rugby Web site by typing in the words 'World Cup Rugby'.
A range of options will appear on the screen, such as specific matches, venues, players, match statistics, and half-time and final scores.
The required information will appear on your screen instantly by continuing to select specific options.
Other Wap-compatible services include the retrieval of news headlines, traffic and weather reports, and Internet banking.
"One can imagine the potential Wap holds for future wireless mobile applications, but it would be unrealistic to expect that this technology will influence the mass market in a revolutionary way within the next eight to 12 months," says Cousins.
"And, of course, Wap will not come cheap," he warns.
"First you have to have the right cellular handset, then the additional airtime spent on the handset will also add an extra couple of hundred rands on to your phone bill every month – depending on how often you use the Wap Internet browsing facility," he says.
Siemens has been the first to conduct its own Wap trial in South Africa, and will be launching Wap early next year after the Wap Gateway has been installed and tested on the cellular network.
The Wap Gateway enables information to pass through from the Internet to the cellular network, and on to the cellular handsets of the end-users.
Edited by: System Author© Reuse this Comment Guidelines (150 word limit)
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Creamer Media's Road and Rail 2014 report examines South Africa's road and rail transport system, with particular focus on the size and state of the country's road and rail network, the funding and maintenance of these respective networks, and the push to move road...
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This edition drills down into the performance and outlook for a variety of sectors, including automotive, construction, electricity, transport, steel, water, coal, gold, iron-ore and platinum.
Real Economy Insight: Automotive 2014 (PDF Report)
This four-page brief covers key developments in the automotive industry over the past 12 months, including an overview of South Africa's automotive market, trade figures, production and the policies influencing the sector.
Real Economy Insight: Construction 2014 (PDF Report)
This five-page brief covers key developments in the construction industry over the past 12 months. It provides an overview of the sector and includes details of employment in the sector, infrastructure and municipal spending, as well as insight into companies'...
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This five-page brief covers key developments in the electricity industry over the past 12 months, including details of State-owned power utility Eskom's generation activities, funding and tariffs, independent power producers and prospects for the sector.
This Week's Magazine
JSE-listed real estate investment trust (REIT) Rebosis Property Fund achieved a distribution growth of 8.1% to 99.45c per linked unit in the financial year ended August 31, despite volatile market conditions.
A low-cost, inflatable incubator won this year's international James Dyson design award, which aims to encourage and inspire the next generation of design engineers.
The World Bank released its 'Doing Business 2015: Going Beyond Efficiency' report last month and ranked South Africa 43 out of 189 global economies for its ease of doing business, with Singapore topping the rankings.
Air Products South Africa officially launched its R300-million Eastern Cape air- separation unit (ASU), at its new manufacturing facility in the Coega Industrial Development Zone (IDZ), earlier this month. It is the second facility that Air Products launched in South...
BMW South Africa (SA) has signed a power purchasing agreement with energy company Bio2Watt. The offtake partnership will bring renewable energy to the carmaker's Rosslyn plant, north of Pretoria.


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25 Years in, the Urge Still Selling Out Venues
By Melinda Cooper
The 100 Greatest St. Louis Songs
By RFT Music
"Music You Know" Draws Inspiration from the Familiar
By Allison Babka
Pokey LaFarge Signs to Rounder Records
By Daniel Hill
Miami Dolphins Is Not a Football Team
By Drew Ailes
Combating a Rash of Tour Van Break-Ins
By Brian Heffernan
Grammophone to Close, Reopen As Restaurant
By Joseph Hess
Playing for the Cause Helps Out Those in Need
By Joseph Hess
The therapeutic obsession inherent in the singer-songwriter genre is enough to send listeners straight to the crack pipe (if not the razorblade). Solo strummers often forget that music isn't about getting in touch with the self; it's about getting in touch with music. Though she holds a PhD in clinical psychology, New York new folkie Lucy Kaplansky mostly understands how music trumps confession, even as she's clearly mastered the risky art of self-spelunking. On last year's Over the Hills she turns the experience of motherhood into a country-rock workout with enough fuzz-and-sparkle steel guitar, doubled vocals and slapping congas to illuminate the bare acoustic guitar figures — or to transform Bryan Ferry's "More Than This" into a sonic dreamscape that's more Roxy than folkie.


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Latest News
2014-2015 Public Ice Time Schedule Now Available.21 Nov 2014
The Sunderland, Cannington and Beaverton Arenas offer public skating, moms & tots, and shinny hockey throughout the fall/winter season. To view an…
Appointments to Boards & Committees13 Nov 2014
APPOINTMENTS The Corporation of the Township of Brock is seeking community-minded individuals to put forth their names for consideration as…
Blackwater Bridge Reconstruction – Road Closure Notice12 Nov 2014
Please click here to see a notice regarding a road closure on Concession 4 (Brock).
New Tender & Quotation Request12 Nov 2014
Please visit the Tenders and Competitions section to view a tender for a Snow Plow and Tailgate Sander and a Quotation Request for…


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G-III Women's Detroit Red Wings Lace-Up T-Shirt
$34.93 $49.99*
Save $15.06 (30%)
Product Information:
From the first puck drop to the finals, cheer on the Red Wings with the G-III® Women's Detroit Red Wings Lace-Up T-Shirt. The team logo tri-blend material will keep you stylish and comfortable throughout the season. Show your Detroit pride in the G-III® Lace-Up T-Shirt.
- Tri-blend, long sleeve shirt
- Lace-up collar
- Team-colored stripes on sleeve
- Team logo and year of establishment screen-printed on front
- Fabric: 50% polyester, 37% cotton, 13% rayon
Country of Origin: ImportedWeb ID: 16691796


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- Publisher: Bethesda Softworks
- Release Date: Jun 3, 2003
User Score
Generally favorable reviews- based on 79 Ratings
User score distribution:
Positive: 72 out of 79
Mixed: 4 out of 79
Negative: 3 out of 79
Review this game
- User score
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- By date
- Most helpful
- Most Clicked
Oct 23, 2010The new werewolf questline is great and adds even more fun and open elements to an already massive world. This game and the mods added by the community is still hard to match.
Mar 11, 2011A nice expansion. Morrowind had enough places to explore. Morrowind didn't need an expansion, but it got one and it added more than I expected it would.
Aug 18, 2012Bloodmoon is DLC done right; the land is vast but varied making it interesting to explore. The entire place has a vibe to it and a different culture to make it interesting. Yes, in case you're wondering Bloodmoon's island is pretty much a smaller version of Skyrim; so if you don't like snow, glaciers, mountains or other spectacular scenery then this probably isn't for you. If you aren't boring and actually like sweeping vistas and a unique culture then Bloodmoon is a perfect piece of DLC that's more or less a smaller version of the main game. If you don't have it, then seek a copy out immediately.… Expand
Aug 2, 2014As much as I love Morrowind to death and really enjoyed the previous DLC Tribunal that was expanding on the main story, after hearing praise on the Bloodmoon DLC, it left me a bit disappointed. The whole thing seems a bit like Skyrim demo to me, Bethesda was trying out winter environments, mountains, snow, ice, werewolves, Nord lore and while Bloodmoon is still quite enjoyable, it just felt like a Skyrim betatest to me. Unfortunately for Bloodmoon, I played Skyrim before Bloodmoon, so that might have hurt my impressions, as in Skyrim all those elements were even better. Still good, but nevertheless, Bloodmoon was the least favourite part of my entire Morrowind experience, which is otherwise still one of the best RPG's ever created to this day. 6/10… Expand
Maybe Bloodmoon could have been down as a free, or low cost, download, but the added value of the werewolf alone make the twenty dollar cost seem like a bargain.
Bloodmoon also adds werewolves and though they're formidable opponents, the real attraction here is that you can actually become a werewolf yourself.
Living as a werewolf is still pretty cool. You can inflict serious damage with those claws, leap amazing distances, and take on more enemies than would be possible in your human form. [Sept 2003, p.74]


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Lincoln Student Council Shirts! by Lincoln Student Council - about 1 year ago
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Week In Style
The Week in Style: 10.28.11
11 of 11
Russell Brand in NYC.
Fact: Russell Brand is incapable of wearing pants with fewer than five zippers. How many zippers do you think died to make this outfit?
- Tags
- Style,
- Week in Style
Food + Travel
- David Chang's Kitchen: Don't Get All "Fresh" with Me
- David Chang's Kitchen: Your Idea of Bologna is Total Baloney
- Chart: The Family Tree of Bourbon Whiskey
- Recipe: Semi-Summer Salad - Chef Jeff Taibe of Oak + Almond
- The Great Franco-Italian Pasta Experiment
- How to Pick from an Overpriced Restaurant Wine List


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youtube.com, Glassdoor
A YouTube video showing answers to the oddest real interview questions asked by major companies this year was launched by Glassdoor Jan. 7.
Ranging anywhere from "How do you make a tuna sandwich?" to "How many cows are in Canada?" the list was compiled after reviewing tens of thousands of interview questions.
The company also released a site with past questions asked to candidates for 13 different positions like intern or manager. There were also questions from 13 different companies, including Amazon.com, Target and Apple.
One in five employees plans on looking for a job in the next three months, so along with the ridiculous questions that could be sprung in the interview, knowing the most commonly asked questions will help the candidates.
"What are your strengths and weaknesses?", "Why did you apply for this job?" and "Where do you see yourself in five years?" are some of the most common questions, according to a Glassdoor press release.
The complete list of 25 strangest questions can be viewed here. We want to hear how you would answer these questions. Email your responses to email@example.com.
- The most expensive homes in Utah in 2014
- 4 unexpected health risks of smartphone use
- There's more to Black Friday than getting a...
- Why 'Shark Tank' investor Barbara Corcoran...
- 5 easy ways to make your money work for you
- How actress Blake Lively's family saves money...
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- How to keep information overload from... 1


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Puppy Bowl IX: Survival of the cutest
Puppy Bowl IX is Animal Planet's answer to the Super Bowl. The battle of the cute airs repeatedly on Sunday. Click through for a preview of the action.
Around The Watercooler
- Town nixes naming park for Pooh due to gender
- Super sad bicyclist just wanted some Taco Bell
- Man stung more than 100 times by swarm of bees
- Strangers lift car to save woman's life
- Tenn. man hit with $3,000 Comcast bill
- Cops: Drunk N.J. man stole bulldozer for ride home
- Americans accused of trying to ship baby parts ID'd
- TV host wore same outfit for a year; no one noticed
- Marijuana-themed sandwich shop opens


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A Plethora Of Cloud Computing Benchmarks
Published on 01 June 2010 03:24 PM EDT
Written by
Michael Larabel
1 Comment
One of the companies that we have been collaborating with on some of the features for the
Phoronix Test Suite
has been
, which is a company that seeks to provide an assortment of information on different cloud computing platforms and offerings from the various firms. Using the Phoronix Test Suite they have been benchmarking a plethora of different cloud computing platforms and today they have published a huge batch of results -- benchmarks from over 150 different cloud server configurations from 20 different providers!
CloudHarmony has long been benchmarking cloud computing platforms and publishing their results on
Phoronix Global
their public test results
), but now they have published an incredible number of tests from many different cloud platforms and configurations. Also on their blog is an extensive analysis of their test results.
Using a number of the different Phoronix Test Suite tests they also end up defining a new cloud computing performance unit: a CCU, or CloudHarmony Compute Unit. Among the cloud providers benchmarked were Amazon EC2, Rackspace Cloud, Storm on Demand, GoGrid, Voxel, NewServers, Linode, SoftLayer, Terremark vCloud Express, OpSource Cloud, Speedyrails, Zerigo, ReliaCloud, IBM Development & Test Cloud, BlueLock, Cloud Central, RimuHosting, ElasticHosts, and Flexiscale. Had it not been for the Phoronix Test Suite and its automated test installation and execution, this cloud benchmarking would have taken an extremely long amount of time.
this blog post
for their analysis of different cloud providers and their results from the 150 different cloud server configurations with 20 different vendors.
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STARmeterSEE RANK
Up 7,856 this week
Simon J. Berger
Simon J. Berger was born on June 1, 1979 in Sweden. He is an actor, known for Call Girl (2012), Instead of Abracadabra (2008) and Det knullande paret (2013). See full bio »
Born:in Sweden
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No. 3 Alabama Drops Penn State
(AP) A.J. McCarron was poised and efficient in a rare trip into Big Ten country for No. 3 Alabama, throwing for 163 yards and a touchdown against No. 23 Penn State in a 27-11 victory on Saturday. Alabama completed a sweep of the home-and-home series between the two storied programs with a methodical and smothering performance reminiscent of last year's 24-3 win in Tuscaloosa. Both teams came into the second week of the season with unsettled quarterback issues. For Penn State, Nittany Lions (1-1) fans might be wondering if either Robert Bolden or Matt McGloin are the answer. They combined to go 12 for 39 for 144 yards. Read the full AP recap, check out the box score and see our Big Ten scoreboard.
Find out more about: Rapid Recaps


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Can you give more information on your grandfather JOHN D. MERCK? I have a John D. Merck who could very well be your grandfather. Was he married more than once? Children? About when was he born? Die? I have about eight total, who could be your John D. Merck, so you will have to more information.
Cliff Merck
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Wake Up To Your Tunes With The iPhone Playlist Alarm Clock App
Yesterday we saw Kensington's take on converting the iPhone into a full blown alarm clock complete with charging stand. Okay, I shouldn't say complete because one very important thing was missing: the alarm clock. More importantly the iPhone is missing one feature in their alarm clock app, which is the ability to wake to your tunes.
The Playlist Alarm Clock from Chilli X allows you to create two playlists: one for falling asleep and one for waking. The app requires you to make a playlist within iTunes or the app itself, but regardless of the amount of songs entered you can set the amount of time they'll play.
Currently the app is void of any 5 star reviews with one reviewer pointing to a flaw that states you can't let the iPhone fall into standby or lock mode otherwise it won't work in wake mode. Another reviewer notes that you can't change the volume of the app and you're unable to randomize the playlist, which means you'll experience the same sequence day after day. I'd probably be able to over look many of these flaws if it were free, but at $0.99 I think I'll pass.
[via Unpluggd]
Read – iTunes App Store
Christen Costa
Grew up back East, got sick of the cold and headed West. Since I was small I have been pushing buttons - both electronic and human. With an insatiable need for tech I thought "why not start a blog focusing on technology, and use my dislikes and likes to post on gadgets."
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A iPhone 5S Covered In Real Gold Can Be Yours
iPad only $140 (+ case), $100 Wireles Printer, Sony Alpha NEX Camera 32% Off


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Hong Kong's Umbrella Movement gets computer game makeover26 Oct 2014 | 01:26
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Police warn punters over soccer betting on overseas websites
Posted Jun 01st 2010, 12:00am by Martin Wong
... as the World Cup approaches. With the event starting on June 11 in South Africa, organised crime and triad bureau superintendent Man Tat-shing predicted illegal soccer gambling would increase. 'And cyber gambling is a challenge, not only to us but also to our counterparts on the mainland and overseas.' Man added that a group comprising officers from the triad bureau, commercial ...http://www.scmp.com/article/715877/police-warn-punters-over-soccer-betting-overseas-websites
Officer sues police commissioner in testimony row
Posted Oct 01st 2011, 12:00am
... of justice by coercing the attacker- Shing Wo triad member Ken Chan Ying-kin- into falsifying the identity of the attack's orchestrator, Ken Chan's triad 'big brother' member ...http://www.scmp.com/article/980608/officer-sues-police-commissioner-testimony-row
News - Hong Kong - CRIME
Fake liquor seized from Tsim Sha Tsui pub as triad scam busted
Posted Aug 14th 2012, 12:00am by Clifford Lo
... TRIAD FAKE LIQUOR SCAM BUSTED More than 600 bottles of liquor bearing famous brand names but thought to contain cheap alcohol were seized from a pub in Tsim Sha Tsui in an anti-triad operation that netted 86 arrests. One anti-triad officer said the pub was trying to cheat young drinkers who might struggle to tell the difference between cheap and expensive liquor- especially when they had ...http://www.scmp.com/news/hong-kong/article/1013817/fake-liquor-seized-tsim-sha-tsui-pub-triad-scam-busted
Man jailed for burgling own house
Posted Oct 06th 2010, 12:00am by Austin Chiu
... and electronic devices. The court heard that he needed to settle a triad loan given to save his business. ...http://www.scmp.com/article/726685/man-jailed-burgling-own-house
In Brief
Posted Dec 03rd 2009, 12:00am by Staff Reporter
... Six suspected triads arrested Six suspected triad members, aged 16 to 19, were arrested for unlawful assembly outside Yuk Ping House on Long Ping Estate, Yuen Long, at about 12.10am and several wooden batons were seized. ...http://www.scmp.com/article/700124/brief
Bond for triad claim
Posted Jul 05th 2007, 12:00am by Staff Reporter
... Chandra Wong A secondary school student who claimed in an internet forum to be related to a triad society, 'for fun only', has been put on a good-behaviour bond. Student Li ... and Triad Bureau arrested the student in March this year under the Criminal Procedure Ordinance for claiming to be a member of a triad society. The police later agreed to release the youth after ...http://www.scmp.com/article/599339/bond-triad-claim
Two 'office-bearers' among 23 triad suspects arrested
Posted May 01st 2009, 12:00am by Clifford Lo
... Clifford Lo Twenty-three suspected triad members, including four students, were arrested in raids in Tseung Kwan O in the past two days after a two-month probe into recruitment. More than 100 officers from the Kowloon East anti-triad squad and police tactical unit raided about 30 locations during an operation at 4pm on Wednesday. Nine people were arrested on Wednesday ...http://www.scmp.com/article/678747/two-office-bearers-among-23-triad-suspects-arrested
28 Wo On Lok triad members arrested in raids
Posted Apr 24th 2010, 12:00am by Clifford Lo
... Clifford Lo The alleged former dragonhead and 27 active members of the Wo On Lok triad society were arrested in a series of raids yesterday after a 14-month undercover operation. The weapons arsenal of the triad, also known as 'Shui Fong', was discovered in a flat in Hong Lok Street, Mong Kok, during the operation. About 20 sharpened metal bars, water pipes ...http://www.scmp.com/article/712354/28-wo-lok-triad-members-arrested-raids
City Briefs
Posted Oct 01st 2003, 12:00am by Staff Reporter
... Three held over assault Three alleged 14K triad members were arrested for injuring a member of a rival gang in Yuen Long. The three were among 10 men who attacked a group of six or seven suspected Wo Shing Wo triad members in Sai Yu Street, police said. ...http://www.scmp.com/article/429699/city-briefs
Police arrest HK man for allegedly threatening Japanese officials
Posted Jul 13th 2006, 12:00am by Staff Reporter
... criminals? responsible for major atrocities in Asia during World War II. The Japanese official is tipped to become its next prime minister.?Inquiries by the Organised Crime and Triad Bureau ...http://www.scmp.com/article/556354/police-arrest-hk-man-allegedly-threatening-japanese-officials
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"We'll be sure to keep you informed, ma'am," Spinel said before she turned to walk with Markus. "I know you had your eye on the tower, but would you mind a quick stop at the center? I need to heal my Pokemon, and perhaps it would be wise we leave our eggs with Nurse Joy while we explore."
Spinel wasn't sure. It didn't appear that there was a lot going on in the tower, but still her Pokemon needed to be healed. The only one that was at full health was Ren, and she was still acting a little off. If it came to battling she'd have to take a step back and let her comrades handle it. It could be good experience for them, but if they needed back-up and she couldn't provide it... That was not an option.
"I need to stop at the Pokemon Center. Either you guys can go on ahead and I'll catch up or we can all go together and stay as a group."
Spinel was a bit curious as to how this Nurse Joy knew their names, but she decided to let it go for now. She followed the older woman as they walked through the center.
"I am a little concerned as to the health of the Pokemon Egg I'm carrying," she said. "Also, if it would not be too much trouble to you, I would like my other Pokemon checked over. My Totodile has not been feeling well, and my others were in a couple battles just outside of the city."


text:
There may not be any wizards' academies in South Central Los Angeles, but Booth newcomer C. Hutch did manage to pick up a little Avenue Magic during his time in the mean streets. What type of spells does he have up his sleeve, you may ask? As Hutch explains on this newly-leaked mixtape cut, he's got quite a few enviable powers: he can make cash appear out of thin air, he can gain respect with a wave of his hand, he can even hustle in his sleep! On top of all that, he's got some impressive multitasking abilities—in addition to showcasing his skills on the mic with three verses' worth of punchline-laced braggadocio, he steps behind the boards to deliver chopped-sample instrumental whose leisurely rhythm couldn't be better matched to his swagger-drenched flow. C. Hutch may not have a Hogwarts diploma, but he comes with a brand of street magic we can all believe in; for more spellbinding tracks, grab a copy of Black Market Music when it hits the net September 1st.
Written by richard on 08/6/09
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Hi everyone,
I am a new brewer and have gotten a lot of helpful advice from this forum and ideas from viewing other peoples rigs. I finally figured I would post my own.
The Key to brewing in an apartment is upgrading the large stove coils to "Canning coils". they ROCK! Here is a pic of one of them installed, its the rear coil in the pic. Not only do they heat the water very fast, they are raised higher then the standard coils as well as are reinforced to hold large amounts of weight.http://imageshack.us/photo/my-images/822/img0039dq.jpg
My last brew session i timed everything to be able give people an idea what stove top brewing is like.
In the following pictures I am using my 6 gallon stainless pots to boil in, I have recently switched back to using my 5 gal aluminum pots because they heat the water faster. I will update this next time i use the stainless steel pots just for comparison.
Time Trial with Aluminum Pots, using 4.5 kg 2 row, .5 kg roasted barley:
Started with 150 Degree F, 7.6 gal tap water.
0:07 Water hits 170 F, started Mash, turned off stovehttp://imageshack.us/f/20/img0042hh.jpg
1:07 Mash completed, removed mash bag, temperature of mash is 180 F 6.4gal water, 1.028 gravity
(1.056 after temp correction to 68 degrees F)http://imageshack.us/f/692/img0047ic.jpg
1:37 Temp reaches 210 F, Boil startshttp://imageshack.us/f/829/img0050jk.jpg
3 hop add ins at time intervals 60 30 10
2:27 Put a mash bag in one pot, put the immersion chiller in second pot to sterilize them
2:37 Boil Finished, 5.5 Gallons left, starting cooling each pot using one 20 ft of 1/2 inch immersion chiller
2:43 First pot hit 90F
2:50 Second pot hit 90F, Put mash bag in sanitized 6 gallon pot, dump both pots into 6 gallon pot. sterilize hands and squeeze wort through bag. after having many spills in my kitchen, i now make this transfer in the tub, that way if i spill its not a big deal. I also put a cutting board under the 6 gal pot so it doesnt scratch the paint on the steel tub.
Here is a pic of the left over trub from straining through hop bag, and yes it tastes just as ****ty as it looks haha:http://imageshack.us/f/819/img0056ie.jpg
I made two batches this day so this picture is actually 10 gallons worth of trub.
2:57 put pot in fermenting fridge which is set at 65 degrees F.
Done! 5.25 gal, 1.058 at 90 deg F
(1.061 adjusted to 68 deg F)
Here are some pics of my fermenting closet.http://imageshack.us/f/838/img0058fh.jpghttp://imageshack.us/f/198/img0059lr.jpghttp://imageshack.us/f/59/img0060ai.jpghttp://imageshack.us/f/600/img0061xk.jpg
I have two digitally temp controlled fermenters on the left and a statically controlled fridge on the right. The fridge was set by getting a glass of water to the temperature i wanted the fridge to be set at, then immersing the thermostat into the water and adjusting the thermostat adjustment internal set screw til the main dial was within the range i wanted the fridge to be.
I thought that I would have major overheating temperature issues with all these fridges in one closet, but I just leave the door open. Even with the door closed, I was suprised on how little they heat up the room.
Each fermentation fridge is controlled by a Johnson 419 temp controller and easily holds 2 x 6 gallon fermenters. If i want I can seal the fermenters using a 15" oring, binder clips, large drilled holes and plugs with blowoff tubes. But I find that beer really doesnt need to be completely pressure sealed, so I usually just put the lids on and cover the blowoff holes. The two fermentation fridges also have collars installed behind the seals, much like people do with freezers. Without these collars I cant fit in two pots due to the compressors in the bottom of the fridges.
One day I will install shelves but 2x4's seem to do the trick for now.
Add Yeast next day when wort is a expected temp
Interesting side benefits:
Since i am using a pot to ferment in, i can easily just sanitize my hydrometer and stick it in my pot as shown here:http://imageshack.us/f/27/img0055qoi.jpg
I like to remove the krausen after about 3 days of fermentation. Some people say its bad to mess with the beer, but I have noticed that the beer tends to taste cleaner by removing the krausen and straining the trub after cooling. But then again, I have yet to have a keg last 2 weeks past it finishing fermentation so maybe straining and removing krausen is pointless if you let your beer age? Hopefully one day I will be able to find out.
5 and 6 gallon pots are perfect for washing in the sink! they barely fit under the faucet and are easily fillable and washable.
I am a big fan of the digital temperature probes, they sell them at XScargo here in london for 10$ each. They allow you to set time alarms, temerature alarms, and allow u to get a temperature at a glance anytime you want. I just "mentally" calibrate them to my johnson temp controllers. Everyone I have checked, they always seem to read exactly 2 degrees F high, wierd.
Hope someone finds something in these ramblings useful haha
If anyone has any questions, comments or advice, I am always interested!
My efficiencies seem a bit high? I will have to verify with my next batch.
I tired boiling 5 gallons on my stove with my aluminum pot and it bent my stove from the weight when it got hot....
Hi Jarrat, I would swap out your coils for canning coils. They have much stronger supports and would have no problem holding the weight.