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Benefit for Acadiana Baby with Neuroblastoma
Baby Jack's family and friends have come together to help the family through these next fifteen to eighteen months of treatment by hosting a benefit on May 31, 2014.
Baby Jack's family and friends have come together to help the family through these next fifteen to eighteen months of treatment by hosting a benefit on May 31, 2014.
Willie Robertson, of A&E's 'Duck Dynasty' was the guest speaker at Acadian Ambulance's Paramedic of the Year Luncheon at the Lafayette Convention Center in Lafayette.
The event will also include lots of free family activities: crafts, face painting, a fun jump, a petting zoo, and more!
The likes of Marc Broussard, Steve Adams, T.K. Hulin, Charlene Howard and a host of others came together at The District last night for a fundraiser for Glen Guilbeau .
It's no big secret as to how I feel about Charlene Howard the person/the talent, and tonight you get to see and hear exactly what I've been preaching for years...SHE'S AMAZING!
NCAA softball regionals, baseball and graduation ceremonies will bring a lot of traffic to the area.
Michael Jackson The Immortal World Tour By Cirque Du Soleil is coming to Lafayette's Cajundome July 29 and 30. This will be an amazing show for Michael Jackson fans and music enthusiasts.
People in South Louisiana have a way of really stepping up to the plate when folks need help. An Acadiana native has been hit hard. One of the area's best known musicians, Louisiana Hall of Fame member Glen Guilbeau has suffered a severely debilitating stroke, and the community has mobilized.
Lafayette Parish art students are having a day of visual and performance art at the ACA on Saturday, May 10.
In case you forgot, Mother's Day is Sunday! But Mom isn't the only reason to celebrate this weekend. Here are our picks for fun things to do May 9 - 11, 2014.
Maracas in May is proudly sponsored by Jose Cuervo and presented by Corona. Additional Maracas sponsors include Coyote Blues, Crescent Crown, La Carreta, Legends Downtown & Annex, Marley's Sports Bar, Schlotzsky's Lafayette (both locations) and Swamp Vapor.
Rammunition will be in Breaux Bridge on May 9 and 10, 2014. The 10 foot tall monster truck will demonstrate the power of its 2000 HP HEMI engine by crushing cars!


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Holly Mackey is 16, and she's on a mission. She wants to talk to Detective Stephen Moran and show him a card she's found.It's a photo of a good-looking young man, Chris Harper, who was murdered the year before on the grounds of St. Kilda's, the private girls' school she attends in the suburbs of Dublin. Under the photo are the words: "I know who killed him."Holly's own father is a detective, but she brings the card to Stephen, who worked with her when she was 9 and a witness to a murder. Stephen isn't part of Dublin's Murder Squad — he's stuck in Cold Cases — but he'd like to be. He takes the information to Detective Antoinette Conway, the tough-minded, rough-spoken woman who has had the case for a year but has been unable to get anywhere with it. Just as he sees this as a chance to show Murder what he can do, she sees this as an opportunity to use his connections to Holly, and the two head out to St. Kilda's to find the killer. The search will begin where Holly found the card: on "The Secret Place," a board where girls are encouraged to post the innermost thoughts they want to share, but anonymously. So begins The Secret Place, the fifth novel by Irish author and actress Tana French. All have focused on Dublin's Murder Squad, and all have met with critical acclaim. Moran, Holly and her father, Frank Mackey, were, in fact, characters in French's 2010 book, Faithful Place, which takes place in that year when Holly was a witness. And while reading the books as a series, in order, would most likely add to the richness of the experience, for those readers who are diving into French's novels for the first time, like me, this book stands alone quite well.The narration goes back and forth between first person, in which Moran is the narrator, and third person. Moran's narration is in the present tense and follows the events at St. Kilda's in the course of his investigation with Conway. Dropped in between these chapters is a third-person narration used to return readers to the past, beginning about seven months before Harper's death. In these we follow the lives of Holly and her best friends, Julia, Selena and Rebecca. We also learn about their rival group, a foursome including Joanne, the bossy leader, and Gemma, Orla and Alison, her devoted and/or petrified followers. It's a great structure, providing lots of forward-moving action with intriguingly dropped clues and red herrings, as well as a plethora of detail-filled scenes that create a strong sense of place. The symmetry of this book is also beautiful — the book starts with Holly and ends with Holly in a nimble, clever way. French is a beautiful writer. Her dialogue almost begs to be read aloud to enjoy the Irish accent. (When Conway says she is worried the guys back at Murder will hassle her about the case and about Moran, he replies, " 'I've ignored eejits before. I can do it again.' Hoped to Jaysus the squad room would be empty whenever we walked in there. Last thing I wanted to do was pick between pissing off Conway and pissing off the Murder lads.") Her teen girls sound authentic. (Overheard from obnoxious Joanne at breakfast: "Hello, it was in Elle, don't you read? It's supposed to be totes amazeballs, and let's face it, I mean not being mean, but you could do with an amazeballs exfoliator, couldn't you, Orls?") The girls are, as a whole, emotional and touchy, and they live in a bubble of a world of privilege, thinking almost exclusively about themselves. All of that rings true.In addition, sentences are perfectly polished and crisp, like these: "The night was turning that red jumper the color of a banked fire, compressed and waiting. … I looked at Conway across that lone gallant slash of red." "They're eating breakfast when Holly feels the thread tug of something gone wrong, deep in the weave of the school." "Everything slams into focus, bright colors inside sharp outlines. … The prickle of her zipper down her back is a tiny precise line. She's looking straight into Chris' eyes, hazel even in the dimness, but somehow she can see the hall as well and the lights aren't signals or lost things, they're lights and she never knew anything could be so red and so pink and so white."There is so much to like about this book, and yet, for me, there was also a darkness to it that made it hard to read. In fact, I had to put the book down for a few days because even though the plotline was compelling me to blaze ahead, I struggled with the hardness of the characters, especially Conway, Joanne and Julia. While not everyone agrees that it's important to like the central characters in a book, I prefer books where I feel that sort of connection. And in this book I didn't particularly care for any of the characters.One of the problems may be that French placed the two groups of four girls into the bull's-eye as possible suspects. Even with a 450-page book, these are a lot of characters to try to develop — especially since she's also working on Conway and Moran and their relationship. I didn't feel like she succeeded in giving the schoolgirls, other than Holly, richly developed characters. In fact, at one point I created a chart in the back of the book to help me try to remember who was who. Their relationships with each other, which become vital to the plotline, weren't deeply explored either.Luckily, it's the plot that ultimately drives this thriller, and the last 50 pages of the book take the reader on a highly satisfying, fast-paced ride gradually revealing whodunnit and tying up loose ends, and then careening us back to the beginning. And that's where I found myself going, returning to the first chapters with a deep appreciation for French's plotting and structural skills and a keen desire to re-read and to revisit, with the detectives, The Secret Place. Except this time, as I read, enjoying the action as it began to unfold again, I knew who killed him, too, and everything looked delightfully different.
The Secret Place
by Tana French
Viking, $27.95
* * * * Audiobook: Penguin Audio ($50); narrated by actors Stephen Hogan and Lara Hutchinson.
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So far so good. I was almost going to give up finding part until I got to your site.Read More ->
In 2007, I purchased a Fire Magic 36" Monarch Magnum grill. Recently, my ignition switch failed and I went "online" to find a part. Lacking any...Read More ->
The other day you sent me a link to a part that I was searching for and wanted to buy. Thanks for your quick response to my plight. ...Read More ->


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Chalcedony, Pearl & Onyx NecklaceSoft blue chalcedony, peach pearls and black onyx necklace. It is 19 inches long with a 4 3/4 inch extender chain.The peach pearls and blue chalcedony alone would make a charming piece of jewelry. The black onyx elevates this into an edgy modern necklace. It is also a bit quirky - it's balanced, but not symmetrical. All shine, but with different degrees of shimmer. The pear shaped pearls add variety to the spherical chalcedony and onyx. In other words, this is a very unique, cutting edge necklace.It is perfect for the modern bride, the fashion forward executive, the on the way to the top administrator.FREE GIFT WRAP. Each piece of jewelry is wrapped in tissue paper and enclosed in an organza bag.For some of our other pendants and necklaces, please click:http://www.etsy.com/shop/ExoticTreasuresJewel?section_id=10223063Earrings: http://www.etsy.com/shop/ExoticTreasuresJewel?section_id=10217134Gemstone necklaces:http://www.etsy.com/shop/ExoticTreasuresJewel?section_id=10374495Religious Jewelry:http://www.etsy.com/shop/ExoticTreasuresJewel?section_id=10217106
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The Liaison Capitol Hill, An Affinia Hotel
No availability found through our partners. Please contact the business directly or check some of our recommended alternatives.
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Historical Traveler Reviews The Liaison Capitol Hill, An Affinia Hotel Washington DC
Great Location - Great Hotel - Affinia Hotels will make it better!!!
Well....... after reading the reviews of this hotel when it was the Holiday Inn on the Hill - Washington, I thought I had made the biggest mistake in the world. I have worked in hotels for the past 18 years, and took advantage of reduced staff rates availabe at other Holiday Inn's. On the 1st April the hotel changed from a Holiday Inn to an Affina Hotel and rebranded as The Liaison Capitol Hill. I was very surprised by this and contacted the hotel about my reservation, I was informed that they would still honour my reservation at the staff reduced rate - THEY WERE UNDER NO OBLIGATION TO DO THIS - this was fantastic news. Obviously I was still concerned about comments I had previously read about the old named hotel (bad staff/refurb noise/room issues). WELL let me tell you how great our experience was at The Liaison. We arrived by the Super Shuttle from Washington Dulles airport and was met by a very helpful Bellman who assisted with our extensive luggage. Inside the hotel the receptionist was extremely helpful and chatty, asking where we had come from, what we were planning to do whilst we were here. She also noticed we had booked 2 rooms and they were not close to each other, without even being asked she offered to move them so they were connecting rooms - which was great as we were travelling with our 2 friends. There was also a welcome cherry drink she invited us to try. Our rooms were allocated on the 2nd Floor (which in the USA is actually the 1st Floor - as they class the ground floor as 1st Floor!). Ice Machine just down the corridor. These rooms were just great - 2 double beds with duvets, feather toppers on the mattress and 4 lovely pillows. the hotel also had a pillow menu, where you could choose from one of 6 different types of pillows. Bathroom was nice with tub and powerful shower over. Toilet and sink unit. Room had coffee maker, safe, 3 drawers and hanging space. We still had the old style CRT television, but thet were actively changing them in rooms to the new large screen LCD ones. We also received a new alarm clock radio in our room during our stay. I also know they are putting fridge in the rooms as well. Yes, the restaurant was still under final stages of refurbishment - but wo comes to Washington on a holiday/short break and then eat in the hotel, we certainly didn't. You come to a city to experinece the different restaurants etc. People had complained about noise from refurbishments - well we were immediatley above the restaurant and heard no noise before 9am and then it was only a little hammering. The hotel has a business centre (well a room with colour printer and PC with FREE internet access) this was very useful for checking emails and checking in for our internal flight. The hotel is opposite the Hyatt and very very close to the Capitol Building - also Union Station was only 2 blocks away, where there we plenty of eating establishments and also access to the Metro. Once Affinia Hotels have finished adding the final touches to this hotel it will be even better than it is now. Its not perfect and not a 5 Star hotel, but very resonably priced (even on standard prices). I wish the general public would realise that you get what you pay for in life - and this is also true of hotels. If you rae paying �500 per night, then yes you should get exceptional service and facilities, but if you are paying around �100 then you are getting very good value for money - and YES, thigs might go wrong occasionally - as no one is perfect. I will be writing to the General Manager at the hotel and thanking him for a very enjoyable 5 night stay at The Liaison. (Please note from reading previous reviews, he takes interest on the reviews on here and replies which I think is excellent customer service.) I have pictures that I will try and upload
Good stay
We stayed at The Liasion 4/19-4/23 for 4 nights. We enjoyed our stay very much.
There was only one problem, at check in. They had us down for 3 rooms instead of 2 adjoining we requested. Problem quickly fixed. So we go up to the rooms, and see there is not the flat screen tv's the hotel website said, and there are no fridges as promised. The fridges were vital as we brought water bottles and juice. The fridges were brought up though within a few hours. There were not flatscreens because the hotel "had not installed them yet." An apology was given.
The rooms were incredibly clean. Housekeeping was top-par. Unfortunately the restaurant was closed for renovations, but the Hyatt across the street is good, but VERY pricey for breakfast.
Business Center was nice, not a center but more like a computer in a small room, but the room was very cozy.
Gift Shop was very small, but still had most goods like meds, ice cream, stamps, postcards, some t-shirts, etc.
Ice machines were not installed on our floor, so we had to go from our floor (4th) to the 7th to get ice, although as we were leaving I saw them installing the machine.
Lobby was nice. A DELICIOUS complimentary juice drink was offered in the lobby.
Front Desk could not be nicer, and neither could the bellhop at the front door. Overall, we enjoyed our stay here, and would return.
Thank you so much for your feedback. We appreciate your comments and feedback and are pleased that you had an enjoyable stay. We hope you'll return this summer to enjoy the completed renovations, our rooftop pool and our destination restaurant!
Best regards,
Dani Elhachem
General Manager
Still a Holiday Inn
Still feels like a Holiday Inn. They are trying to upgrade the hotel but it definitely doesn't feel like anything close to upscale. It fit our needs for a hotel close to a metro stop in the area, but I wouldn't go back. Still doing renovations so we heard quite a bit of drilling and other contruction noise up until about 7:30 at night.
I appreciate your feedback. Each experience, the good and the not-so-good are valued and help us to perfect the way that we bring you the Affinia experience of providing you with customized comfort. I apologize that your experience was not as enjoyable as it should have been. We are currently going through minor adjustments that will be completed soon and we are confident that if you return once they are completed you will be pleasantly surprised.
Best Regards,
Dani Elhachem
General Manager
The Liaison Capitol Hill, An Affinia Hotel
A Great Location & Great Room
I was recommended this hotel from a friend who travels the Capitol HIll area often as a family friendly hotel. When I booked the hotel it was Holiday Inn on the Hill. After booking, I found this site & was shocked reading the reviews, I did read that they were changing the name as of April 1st. Well a pleasant April fools day joke!
We found this hotel very clean with a friendly & helpful staff. The rooms were clean & large enough. Yes, we did see some construction in progress, but not on our floor. We never even heard a hammer. We were out during most of the day . The restaurant was not open yet, but I bet you could walk across the street & eat at the Hyatt. Everyday we took a quick 2 block walk to Union Station that had several sit down restaurants & a large food court. Lots of shopping & several tours originate there.
We would definitely recommend this hotel depending on your needs. We did not see the pool area. Mainly we were interested in a clean, safe hotel with a great centralized location to the sites. We walked to the Capitol, the Mall, Air & Space Museum, Natural History Museum, National Achieves (during daylight hours) and felt perfectly safe.
The Liaison topped a great spring break!
The Liason ????
I was really looking forward to this hotel because it looked beautiful. The Liaison site said that it had just completed renovation on April 1st. I booked a room for April 11th. When my husband and I got there, it looked great. Awesome location, about 5 blocks from the national mall area. But......it wasn't even completed. There was no restaurant (still being built), so we had to fend for dinner at 8pm in DC. There were no maps available through the hotel, so bring your own. Also, the room wasn't even finished being painted and the AC wasn't working as well as the TV channels. Another issue was that I did say I was disappointed and felt that Liaison misrepresented themselves by listing all these amenties that were not available. All I got was a blank stare from the receptionist. Oh, well. Hopefully, it will be completed soon because it definately has potential as being a really nice hotel, just not yet.
We strive to have maps readily available for guest at the front desk, I'm sorry if this was not the case during your visit. While Affinia hotels took over management of the hotel on April 1st, there are still adjustments that are being made to the property. Our restaurant is currently under renovation, but we offer our guests detailed information about the many restaurants that are close by and within walking distance. We are very excited about our soon to open restaurant and hope that you will give us another chance and come back to enjoy a spectacular dining experience in our restaurant.
Thank you,
Dani Elhachem
General Manager, The Liaison Capitol Hill, An Affinia Hotel
It was very nice
I was very worried about staying here, based on the reviews I had read. But, I had already made my reservations a month or so before, using a special they had. Well, I was pleasantly surprised by the polite and friendly staff. They were very responsive to my requests, though I only had a few requests. The room was nice, and roomy enough for my son and me. Yes, there was construction going on, but we were rarely in the hotel during the day, and when we were, it wasn't that loud.
The location was great - a short walk to Union Station, where there was a food court, the metro, and the tours that we took originated there, too. Additionally, it was only .25 miles from the Capitol building - and what a sight. There were Capitol police everywhere, so walking on the Mall was very safe. My son and I spent the evenings on the Mall and I always felt we were safe.
For you smokers... This is a non smoking hotel. However, there are benches on either side of the front door for smokers. It was never crowded, and it was very safe.
All in all, I would say this was a great hotel. I suppose it depends on your expectations. If you are looking for a hotel with a good location, that is comfortable, clean and safe, then this is good place for you.
Just before we left, we saw a new name go up on the hotel. When I asked, they said the hotel is changing it's name to The Liaison on April 1, 2008.
TripAdvisor Reviews The Liaison Capitol Hill, An Affinia Hotel Washington DC
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Currently sat on the Amtrak regional train to Washington DC. Yes it is the first proper train journey of our Great Rail Journey holiday.
We were up at 5.45am this morning so feeling a bit tired. I ended up turning the TV off at 1am. They were showing the brand new ep of 'The walking Dead' on AMC but I had missed the first 5 mins & …
DC: The Final Frontier
... class room at the train station. Then we got to meet a baby, Jehan. We only have an hour and a half left on the train ride right now. My favorite part of the trip was the zoo. At all the museums and zoo we got trading coins. I saved up a lot of money so I could go souvenir shopping, and that was my second favorite part of the trip.
Carissa: Today, I learned that my squid can have a baby squid. Today was ...
Washington for a few days
Another early morning and we head out to see what we can see of the US Naval Academy. The answer? Not much. We took the wrong turn and turned into the base rather than the visitors' centre. For some reason, the guard said that our drivers licences were the wrong type of identification and asked us very nicely to turn around and leave the base...lol! So, we did what we were told. If you've read or seen any movies to do with spies, the military, etc, you would proabably be ...
The Capital
... stores such as Macy's and Victoria's Secret. We have lunch and do a spot of wandering around the local shopping mall. Yes, a few purchases are made.
Today is Tuesday and we decide to brave the subway and head in to the Smithsonian Museum - . This takes us about 40 minutes on the train. There are 19 museums in total, all of them enormous. You could spend a week here, visiting and wandering and still not be able to see everything there is to offer. We start ...
A very big thank you!
... basics of Korean and cooking some very yummy Korean cuisine. Thank you all for the adventures, the conversations, the laughs, the hugs, mental support, fun, cooking and nice time we had. You girls were really the best roommates I could have wished for. Undoubtedly, my DC experience would not be close to complete without my internship at Study Sparkz as their operational management and marketing intern. Thank you to the entire Study Sparkz team for making me feel so welcome into ...


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Global Health Seminars: The Global Epidemic of Type 2 Diabetes in the South Asian Diaspora
Global Health Seminar Series
The Global Epidemic of Type 2 Diabetes in the South Asian Diaspora
Sonia Anand, MD, PhD
Date: 12 January 2015, 4:00-5:00 pm
Location: TBA
Special Workshop: Impact Evaluation for Public Health Professionals - Methods, Examples and Future Opportunities
In this session, Professor Colford will discuss a variety of study designs and methods employed by epidemiologists, economists, and public policy investigators to generate evidence through "Impact Evaluations" of public health programs; the focus will be on programs related to global health and development. The underlying principles will be illustrated with detailed examples employing cluster randomized trials, matched cohorts, regression discontinuity, and stepped wedge designs. The role of (and adjustment for) participant compliance will be highlighted with a discussion of a p
Ingénieurs: du laboratoire au marché
[McGill Dobson Cup Start-UP Competition, Second Place Winner in For Profit track: LifePack is a light-weight, powerfully insulating, environmentally-friendly shipping container for temperature sensitive medical materials. Compared to current shipping methods, LifePak reduces packaging waste by 50% and shipping costs by up to 35%.]
Call for proposals: The Muskoka Initiative on Maternal, Newborn and Child Health
On May 28 to 30, 2014, Canada made a committment of $3.5 billion to improve the health of mothers and children for the period of 2015–2020 to end the preventable deaths of mothers, newborn and children younger than age five. These efforts are threefold, focused on strengthening health systems, reducing the burden of leading diseases, and improving nutrition.
CEGEP Panel 2014
Are you interested in teaching at a CEGEP? Attend this panel discussion to hear what recruiters, professors and administrators from CEGEP's have to say about current trends in the labour market for teachers, what CEGEP's look for in new teachers, how teachers are evaluated and how the interview process works.
Participating Cegeps:
Artful Inquiry Salon
I am emailing to extend a warm welcome and reminder for interested faculty and graduate students, to participate in the "Artful Inquiry Salon" scheduled to meet on Wed. Nov. 12th from 2-4pm in Room 233.
"McGill Financial Statements" - Month of October 2014
To all Finance users,
The month of October 2014 is closed. You may pick up your Minerva Financial Statements by logging into Minerva via https://horizon.mcgill.ca/minerva.
This link will bring you directly to the Finance (Fund) Administration Menu >> Financial Statements menu option.
For questions or assistance, you may contact the Finance Helpdesk at 514-398-3463 or via email at fishelp.acct@mcgill.
On the Value of Terrorist's Private Information in Government's Defensive Resource Allocation Problem
Authors: Mohammad E. Nikoofal & Mehmet Gumus
Publication: IIE Transactions
Classic Catalogue, auto-loan machine downtime Monday, November 10, 12:15am - 12:45am
Due to scheduled maintenance, the Classic Catalogue, item-availablity information in McGill WorldCat and the auto-loan machines will be unavailable from 12:15am to 12:45am, Monday morning, November 10, 2014.
We apologize for any inconvenience.


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!Now Hiring!
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Monaco Government Tourist and Convention Bureau
565, Fifth Avenue - 23rd Floor
New York, N.Y. 10017
Tel: +1 212 286 33 30
Fax: +1 212 286 98 90
Toll free (USA): (800) 753 9696
Collective Om and Studio Shala of Monaco are offering a free yoga day on 21 June 2014, on the terraces of the Monte-Carlo Casino
The aim of the organizers, Collective OM and Studio Shala, is to bring together the whole of the Côte d'Azur yoga community in one place for the first time to celebrate yoga and the summer solstice.
The idea was inspired by events such as those in Times Square, New York, the Grand Palais in Paris and the Freeyoga events in Barcelona and Madrid.
More than a thousand people are expected, to relax, breathe, meditate and practice yoga on the terraces of the Casino, overlooking the Mediterranean.
The yoga class will be led by Nico Luce, an international master guru. Yogi Alexander will open the ceremony with a meditation.
The summer solstice is a celebration of creative expression – dance, music, art and yoga. It's a special day when everyone can open their heart to the idea of well being.
Program for the day:
9.30 a.m.: Yoga park opens
10 a.m.: Meditation
10.30 a.m.: Yoga class
12.30 p.m.: Class ends
1 p.m. to 2 a.m.: Music
Yoga Day
Terraces of the Monte-Carlo Casino
21 June 2014 from 9.30 a.m. to 2 a.m.
More info on www.breatheasone.eu
Contact: email@example.com
Number of views : 330
"The Chakras – the Universe Within Us" Course with Yoga Shala Monaco
Kick Boxing will be in the Spotlight in 2015 at the 3rd Monte-Carlo Fighting Masters
Special "Ladies and Children" Introductory Krav Maga Classes in Monaco
Georges Bertellotti Golden Podiums Awards Evening at the Grimaldi Forum Monaco
Woody Allen & Eddy Davis New Orleans Jazz Band in Concert in Monaco
Johnny Hallyday in Concert at the 2015 Monte-Carlo Sporting Summer Festival
Monaco is Hosting the 3rd World Plastic and Reconstructive Surgery Congress
Commemorating the 120th Anniversary of Monaco's Covered Markets
Grisha Bruskin is Exhibiting His Work for Russian Year in Monaco
"Heli Quad" Offer at the Château de Berne with Héli Air Monaco
"Heli Golf" Offer at the Domaine de Terre Blanche with Héli Air Monaco
"Heli Gastronomy" Offer at the Mas du Langoustier with Héli Air Monaco
"Heli Gastronomy" Offer at the La Bastide de Moustiers with Héli Air Monaco
565, Fifth Avenue - 23rd Floor
New York, N.Y. 10017
Tel: +1 212 286 33 30
Fax: +1 212 286 98 90
Toll free (USA): (800) 753 9696


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Join 50,000 ASA members who stay informed and connected.
UPDATE YOUR PROFILE? Login to MyASA and update your professional profile! Login Now »
January 23 - 25 2015, 12:00 AM - 12:00 AM
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View Calendar of Events »
November 07, 2014
FDA MedWatch Nellcor Puritan Bennett 980 Ventilator System Class I Recall
FDA MedWatch Nellcor Puritan Bennett 980 Ventilator System Class I Recall
October 25, 2014
FDA MedWatch Intravia Containers by Baxter Recall
FDA MedWatch Intravia Containers by Baxter Recall
October 20, 2014
FDA Medwatch Alert 10-20-14
FDA Medwatch Alert 10-20-14
View all »
Read more »
AUDIENCE: Risk Manager, Biomedical Engineer
ISSUE: The oxygen and air wall inlet fittings on the back panel of the resuscitation systems were reversed during assembly. These recalled products may interfere with oxygen delivery, resulting in inaccurate oxygen regulation in newborns (neonates), and may lead to low blood oxygen (hypoxia) or high blood oxygen (hyperoxia). This may cause death in neonates, particularly those who are critically ill. Preterm and low-birth weight babies are also at increased risk in terms of morbidity and mortality. The affected products were manufactured from April 1, 2007 through October 31, 2013 and distributed from October 1, 2007 through October 31, 2013. The recall effected the folloiwng models: Giraffe Warmer with Resuscitation System, Panda Warmer with Resuscitation System, Giraffe Stand-Alone Infant Resuscitation System, Resuscitation System Upgrade Kits, and the Panda Freestanding with Resuscitation System.
See the Recall Notice for more information.
BACKGROUND: On November 18, 2013 GE Healthcare sent an Urgent Medical Device Correction letter, with a return receipt, to all affected customers. The letter identified the products, the problem, and safety instructions to be taken by the customer along with the product correction. The firm recommends their customers alert all potential users in their facilities about the safety notification and the recommended actions.
RECOMMENDATION: The firm recommends their customers alert all potential users in their facilities about the safety notification and the recommended actions.
For questions or concerns regarding this recall, please call the company at 1-800-345-2700, Monday – Friday, 8:00 am – 4:30 pm.
Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:
[02/28/2014 - Recall Notice - FDA]


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You must select a size
Long sleeve dress by NLY TREND. Thin shoulder padding and concealed zipper to reverse.
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Find records of Alma Shook
Find birth, death, marriage, military, and other records of Alma Shook at Ancestry.com.Search for records
Biography & Family History Add details
Alma Shook (born 1911) was born on December 5, 1911. She was born into the Shook family.
Alma had no marriages.
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Possible Relatives
- Catherine Sears Shook
- ·
- Mary Ann Shook
- ·
- Mahalee Emily Shook Henry
- ·
- Jacob Shook
- ·
- Wayne Isaac Shook
- ·
- Mary Shook
- ·
- William Shook
- ·
- Otis Shook
- ·
- Emma J Holberg Shook
- ·
- Emma Jane Holberg Shook
- ·
- Billie Shook
- ·
- Allie Shook
- ·
- Forest L Shook
- ·
- Dorothy Shook
- ·
- Eldon D Shook
- ·
- George W Shook
- ·
- Kathleen Belle Shook
- ·


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1/2 Photos of White Pineapple Jello
Prep Time:
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This recipe was shared with us from some dear friends. My husband and her husband served in the same National Guard unit in Utah. We spent a Thanksgiving with them and this was one of the outstanding salads she prepared.
Units: US | Metric
Serving Size: 1 (242 g)
Servings Per Recipe: 6
Make this season merry, bright and manageable with our easy ideas.


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Wallenda walks the walk for high-wire stunt
Date: February 4, 2010
by: Heidi Kurpiela | A&E Editor
Nik Wallenda made his hometown high-wire debut shortly after 9 a.m. today from the top of One Watergate condominium. High above a mob of cheering Sarasota spectators, Wallenda, 31, embarked on a 600-foot walk from One Watergate condominium to the Ritz-Carlton, Sarasota on a wire rigged 200 feet above street level with no safety harness.
Pausing every few feet to wave to the crowd, Wallenda, the great-grandson of legendary circus performer Karl Wallenda, elicited gasps from the crowd when he knelt on one knee several times and laid flat on his back midway through, balancing the weight of his 190-pound frame on the wire.
"It's really cool and scary," said Ely Nabor, 9, who watched with her family in the parking lot of the Ritz-Carlton, Sarasota. "That's really high up to not have a safety net."
Nabor was among thousands of spectators who gathered around the Ritz this morning to watch the stunt. She attends the same Sarasota church as Wallenda, a native Sarasotan and this year's Circus Sarasota headliner. The spectacle was intended to generate buzz for Circus Sarasota's 2010 season, which runs Feb. 12 to Feb. 28 –– and that it did.
With traffic backed up for a mile in both directions on Tamiami Trail and pedestrians and bicyclists pushing past one another to get a clear view of the wire, downtown residents accustomed to relatively empty sidewalks were amazed by the turnout.
"This is wonderful for Sarasota," said Barbara Keltz, a Broadway Promenade resident. "I think everyone was amazed to see someone do something like this here. My family is visiting from New York and they're all out here this morning. I hope this brings more people to the circus. It's so important we support it."
As for Wallenda: When he reached the end of his wire, he was greeted by best friend and former Circus Sarasota performer Bello Nock, a daredevil clown who last year performed a sway-pole stunt in Five Points Park. Standing on the roof of the Ritz, Wallenda turned to face the crowd, threw his fist the air and pumped it triumphantly.
"I can tell you, there's no view like that view up there," he later said to a sea of reporters. "I've walked the wire across the world and never had the chance to walk it in my hometown, so this is very special to me."
Contact Heidi Kurpiela at email@example.com.
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- Nov
28 The Jazz Club of Sarasota Presents "Jazz at Two" with Alex and Judi Glover
2:00 pm - 4:00 pm
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29 Dickey Betts & Great Southern Charity Concert
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30 St. Andrews Day Celebration
3:00 pm - 4:30 pm
- Dec
2 Perlman Music Program/Suncoast Free Ticket Distribution at USFSM Rotunda for Winter Residency Musical Events
10:00 am - 2:00 pm
Puppy paradise
Com has found a home!
Money man
Lakewood Ranch Town Hall's Finance Director Steve Zielinski is the community's money man, and he's got the cufflinks to prove it.
Observer on the hunt for displays
We're making our list of the best holiday lights displays in East County and checking it twice.


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Posted by Ally Sinyard, 25 October 2013
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text: Flagrant Foul no-calls Basketball Fouls [VIDEO] By Tom Jordan January 5, 2012 1:14 PM Share on Facebook Share on Twitter Are you a basketball fan? Can you spot a foul when you see it? Guess who didn't! Filed Under: tom jordan Category: Sports, Videos Share on Facebook Share on Twitter More Leave a comment Send to a friend! Print this page Pin it! Reddit This! Share on Tumblr! More from XL Country Bozeman Snow Removal Rules North Dakota Man Killed in Avalanche Near Cooke City Senator Tester To ESPN: Televise Montana Football, OR ELSE! Bozeman Area Thanksgiving Weekend Events Best of the Web


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2014 Summer Tour Guide
Once again, summer means high temps and cool tunes. Map it all out here.
Once again, summer means high temps and cool tunes. Map it all out here.
Fresh off their own musical tussle, the two look-alikes are taking aim at Metallica's drummer now.
Former Faces keyboardist Ian MacLagan has a new album, 'United States,' coming out on June 17.
It appears that Paul McCartney is not back to 100 percent perfect health. The rock legend has been forced to postpone the first two weeks of his U.S. tour this summer.
Ozzy Osbourne says that he can't believe he's alive after the life that he's led.
Split since 1996, the Kinks have been in talks to reform for their 50th anniversary.
A reunion with John Frusciante helped the Red Hot Chili Peppers rebound late in the '90s.
This is an unfathomable story.
Two vehicles got into a head-on collision this week on an unlined County Road in North Texas, and the drivers happened to be a man and a woman who had gotten married recently. The crash killed both the husband and the wife, and left three kids without parents.
Steven Tyler performed the intro to 'Dream On' with bottles on tour in Finland.
Tom Petty has released 'American Dream Plan B,' the first single from his upcoming album, 'Hypnotic Eye.'
Do you know what number the Roman Numeral "L" stands for?
Me neither!
And if you know it's 50, good for you. You're very smart and well-rounded.
The NFL has decided to drop the Roman Numerals for Super Bowl 50 in San Francisco in 2016, because the lonely "L" just doesn't work.
Robert Plant rebuked Jimmy Page's calls for a Led Zeppelin reunion.


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Search results for meek mill
Meek Mill Speaks On Dreamchasers 3 [VIDEO]
Meek Mill hasn't lost a step, as he debuted his long-delayed Dreamchasers 3 mixtape yesterday.
Rich Homie Quan ft. Meek Mill & Jeezy – "Type Of Way (Remix)" [LISTEN]
How does this jawn make YOU feel?
Meek Mill Says Cassidy Mentioning Snupe Was "Disrespectful" [Video]
In the latest episode of Elliott Wilson's The Truth, the subject is Meek Mill.
Kendrick Lamar Calls Meek Mill Out In NYC Show, Meek Responds [Photos]
It looks like Kendrick Lamar deemed Meek Mill's "Ooh Kill Em" diss worthy of a response tonight at his concert currently occupying Williamsburg Park in Brooklyn
Cassidy – "Catch A Body (R.I.P. Meek)" (Meek Mill Diss) [Listen]
Meek Mill dropped his Cassidy diss, titled "Kendrick You Next," a few days ago.
New Music: Meek Mill Claps Back At Kendrick Lamar's "Control" Verse With "Ooh Kill 'Em"
Took a little while, but here we are…
Meek Mill – "Kendrick You Next" (Cassidy Diss) [Listen]
Meek Mill went jacking for beats and foreshadowed another diss to come in one fatal swoop in the "Kendrick You Next" freestyle.
New Music: Meek Mill "Lil N***a Snupe", Plus His Response To Kendrick Lamar's "Control" Verse! [Audio + Video]
Meek Milly went BANANAS for his deceased homie and keeps it real about Kendrick's verse…


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Awesome place to live in! Great management!
Awesome place to live in! Great management!
View property, WalkScore, and Driving Directions
Fax: (253) 514-6317
Enjoy a beautiful electric fireplace with our 2 & 3 bedroom apartments for rent at Harbor Pointe in Gig Harbor, WA with washer & dryer, patio or deck, pool, microwave, extra storage, fitnes center, walk-in closet and much more. Our apartment homes were re-designed with you in mind! Imagine hardwood & tile flooring products, granite countertops, brushed stainless steel appliances, smooth cook-top ranges, full-size washer/dryer, and ambundance of features to call home.
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Awesome place to live in! Great management!
As you search for your perfect apartment, please keep in mind that rental rates (including specials and discounts) and availability are very fluid in the apartment industry. Based on many factors, the rental rates (including specials and discounts) and availability can actually change not just daily, but hourly, if not even more quickly. While our advertisers do take steps to keep their information current, the rental rates or availability you may find here now at ForRent.com may not be the same as when you contact the communities.


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If you were invited to a wedding, surely one of the first thing you think is: what should I wear ?! But no need to worry, this decision will be easier to take if properly analyze the event and options. Here we give a number of tips for how to dress for every type of wedding without falling into errors clothing.
The first thing to do is determine the type of wedding, you can analyze what answering this series of questions:
-Where's the wedding?
-What time is the event?
-What season will take place? (Spring, summer, fall or winter)
-What is the dress code stated in the invitation?
Since many times the label of the event is specified, the other 3 considerations will be the main guide to go right to the occasion dress, so we list below the most common types of events and what clothes are most apt to be a guest that stands out for its great style and not be messy or too elegant for the occasion.
Wedding day
This type of wedding can be carried out on a farm or garden, so they are usually outdoors. The type of attire should adapt to the location and time of the wedding was held.
If otherwise specified, the ideal will be a short dress in pastels or bright and accompanied by colored heels. It may take some kind of pattern or applications. The ideal is to keep the most natural makeup and hair can be tied back or loose, but well groomed.
-Tip: Try to avoid dark colors or attire too bright and flashy jewelry.
In a suit in navy or gray be easy to achieve a happier and clear combination. Wears a shirt in pastel tone and a clear, bright or patterned tie. In case you choose not to wear a tie make sure the collar is not opened. Add a scarf to the bag to create a point of interest.
Formal Evening Wedding
Usually it is related to the "black tie" code or "tag" and involves the most elegant attire that you own, which must be specified in the invitation.
Long dress material that looks elegant and sophisticated, can lead drapes, cuts or applications, but avoid patterns. Always'll look better in bright or deep colors like orchid, emerald, burnt red, indigo blue, etc. Forget the big bags and prefer a clutch to carry little cash as indispensable.
-Tip: Invest in a black or dark dress simple classic cut that flatters your body type , this will get you out of trouble transforming with accessories, changing hairstyle and makeup to always look different.
For men, the code "black tie" refers to the use of tuxedo. If the invitation does not indicate (with "strict etiquette") or are not entirely sure, better ask if you need to use it and currently at the wedding tuxedo is what differentiates the boyfriend of others. The ideal is to bring a good quality dark suit and fit you perfectly combined with white shirt cufflinks or cufflinks , tie and a flat shoelace shoe soles and thin .
Cocktail wedding night
Such weddings are less formal and allow a little more freedom to choose the outfit. They are ideal to show your style and stand out with glamorous garments.
The short dresses, above the knee (without being too short), are indicated. Select them in satin fabrics, with rhinestones or applications. Combined with metallic sandals and bold accessories. Makeup can bring a little more intensity, either eyes or lips.
- Tip: In this type of occasion you can be a little more risky and lead the trend of jumpsuits or a formal skirt accompanied by a crop top in structured fabrics like satin or razo.
A dark suit with a shirt without a tie is the best choice. Well If you prefer dark or wear a patterned shirt and get a little more creative with accessories like handkerchiefs , ties treads or lapel pins .
Beach Wedding
This type of wedding can seem complicated, but the most important is choosing the right fabric to look groomed, fresh and ad hoc.
The short to knee dresses will be ideal for light and vaporous fabrics, avoiding the thick, stiff or shiny textures applications. Palette color should be bright and shiny, so it will be better to avoid dark colors (on all black) .Combina with open shoes, if the ceremony will take place on the sand takes into account the high heels and wedge platforms prefer not to bury you. The hair collected will be your best ally in keeping it in place despite the humidity. As for makeup, try to be light and takes leaves of rice to absorb the glow of your face.
-Tip: The maxi dresses are a great choice for this type of wedding; looking designs with backless or bold prints. Prevents fabric are very thin as cotton type shirt as it may seem that you take on swimwear.
The guayabera is the option that is typically specified in the invitation, but even if it is not the best option because it is more formal garment for men in hot climates. Prefer simple designs and combined with beige dress pants or navy blue shoes can be loafers in camel or brown.
-Tip: Espadrilles can be a cool choice and trend, just make sure they are in perfect condition and completely clean, since in the opposite case will make you look unkempt.
So you know how to dress for the different types of wedding. If you have questions about what type of dress code is not hesitate to ask the bride and groom or someone close to lighten. Dress appropriate for each occasion is part of your Personal Branding, this will make you feel comfortable and always look your best version.
By Fernanda Ortega
How to choose. Complete made-to-order custom dress dress
The made-to-order clothes need not always a fact. And if it is less than might have been, it does not persist items of your choice to you witnessed in old age. The average clothes made-to-order will have about two years. And you two, but perhaps many shirts there for years and will be small, you will be tired. This means that there is a need for a new shirt of many lifelong you buy. But how do you choose the normal clothes tailor-made for you. A bad color that does nothing ?? a good impression, unfortunately, many people opt for a shirt that does not match making. When you are looking for a made-to-order clothes, what do you looking for? The first thing to think about what you buy at the tailor sewing a shirt is the finesse after and the quality of the shirt. Visit (End button on the method to be completed helicopter) the last detail. You must go to clothing made-to-order you can afford. Fortunately, the advent of measure in buy online, you will be able to buy clothes tailor made to fit into a small price you would have paid for.
Then you can look at the style you want. And there are many different types of collar that can be selected when the full range is available, you will be able to find what is useful for you. Various options is also cuffs. The color of the clothing on demand is also important. Please do not support the blue or white se, there are many other options that are available. And it results in a change to a ?? shirt have a few slightly different or colorful is good. Clothing and tailor-made, fit well, as long as you look good on a style that you chose, the color can only be improved so that it can be. A great addition to your wardrobe
Saturday, October 18, 2014
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Biosketch / Results /
John George Golfinos, M.D.Associate Professor; Chair of the Department of Neurosurgery
Departments of Neurosurgery (Administration) and Otolaryngology (Otolaryngology)
Clinical Addresses530 FIRST AVENUE
Hours: Mon. 9 - 4:30; Tue. 9 - 4:30; Wed. 9 - 4:30; Thu. 9 - 4:30; Fri. 9 - 4:30
Phone: 212-263-2950
Fax: 212-263-1680
Medical SpecialtiesCancer, Neurosurgery
Medical ExpertiseAcoustic Neuromas, Minimally Invasive Surgery, Head/Brain Injuries, Brain Tumors
Clinical ResponsibilitiesDr. Golfinos, a native New Yorker, trained in neurosurgery at the Barrow Neurological Institute in Phoenix, AZ. He joined the faculty at NYU in 1995 and has a practice devoted solely to the multi-modality treatment of brain tumors, including primary brain tumors, metastatic tumors, acoustic neuromas and skull base tumors. He holds a joint appointment in the department of otolaryngology, reflecting his close collaboration with the neuro-otologists on acoustic neuromas and skull base tumors. Dr. Golfinos is the co-editor, with Dr. Cooper, of the textbook Head Injury. He has served as the chairman of the Young Neurosurgeons Committee of the AANS. Dr. Golfinos also supervises brain tumor operations at Bellevue and Manhattan VA hospitals.
LanguagesFrench, Greek
InsuranceAETNA HMO, AETNA INDEMNITY, AETNA MEDICARE, AETNA POS, AETNA PPO/EPO, EBCBS EPO, EBCBS HLTHY NY, EBCBS HMO, EBCBS INDEMNITY, EBCBS MEDIBLUE, EBCBS PATHWAYS / PATHWAYS ENHANCED, EBCBS POS, EBCBS PPO, LOCAL 1199 PPO, MULTIPLAN/PHCS PPO, Medicare, NYS EMPIRE PLAN, OXFORD EXCHANGE, OXFORD FREEDOM, Oxford Liberty, Oxford Medicare, UHC EPO, UHC HMO, UHC MEDICARE, UHC POS, UHC PPO, UHC TOP TIER, UNITED EXCHANGE- COMPASS
Insurance Disclaimer: Insurance listed above may not be accepted at all office locations. Please confirm prior to each visit. The information presented here may not be complete or may have changed.
Board Certification1998 — Ab Neurological Surgery - Neurological Surgery
Education1988 — Columbia University College of Physicians & Surgeons, Medical Education
1988-1989 — Good Samaritan Reg Med Center, Internship
1989-1995 — Barrow Neurological Institute (Neurosurgery), Residency Training


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HOW CAN YOUR meetings and incentive programs motivate the new generation of producers coming up the ranks? "A cruise will make anybody happy," says Leslie Mularski, director of the National Young Agents Program of the Independent Insurance Agents & Brokers (IIAB) of America in Washington, D.C. "But family time is really an incentive for the younger generation." Bill Connolly, an agent with Evans & Associates of Kinston, N.C., agrees. "If I've been awarded a trip, I want my family ...
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Liz Beck Events
As Featured On "Jessica and Derek- Plum Perfect"
Recycled Bride Blog
As Featured On "Carrie & Drew's Backyard Spring Wedding"
Adventures in Wedding Planning
As Featured On "Placecard Ideas"
Completely Unveiled by Weddings. . .
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In the Neighborhood
PazNaz is proud to host a number of services, groups, and opportunities for connection to you. Please scroll down to learn more about:
Sunrise Preschool, Athletics, Cub Scouts,
Boy Scouts, and The American Heritage Girls
A wonderful place to grow since 1990.
For More Information:
or contact us and schedule a tour appointment at:
Thank you for your interest in Sunrise Preschool.
Providing high quality sports and recreational activities with a goal above the game.
• Men's Open Gym Basketball
Tuesdays at 5:00 pm (ages 30 and older)
and Fridays at 7:00 am (ages 18 and older)
Contact: Chuck Young, 626.254.9881
• Adult Indoor Soccer
Tuesdays and Thursdays 7:30-10:00 pm
Contact: Eddie Keshishian, 818.335.2700
Let's dream together. If there are other sports or recreational activities that you would like to help lead, contact the church office at 626.351.9631.
For More Information:
Dave Coates at 626.303.2181 or firstname.lastname@example.com
Cub Scouting means "doing." Everything in Cub Scouting is designed to have the boys doing things. Activities are used to achieve the aims of Scouting—citizenship training, character development, and personal fitness. Many of the activities happen right in the den and pack. The most important are the weekly den meetings and the monthly pack meetings.
The Cub Scout Program is open to all boys in grades 1-5.
The cost is $130 a year, plus uniform and some activity expenses – Financial Assistance is available. To join they should contact Dave or Tiffany Coates.
For More Information:
Mark Knapp at 626.398.7025
Donna Bignell at 626.445.5005
Boy Scout Troop 21, chartered by the First Church of the Nazarene of Pasadena for over 50 years, is an extremely active and exciting troop. The troop is advancement-oriented, focusing on scouting skills and outdoor activities with a high advancement rate and a high percentage of boys who become Eagle Scouts. Troop 21 takes the Scout Oath seriously, especially the Duty to God. These boys learn to orient their maps with a compass, and find direction for their lives with the moral compass of God's Word, the Bible.
Boys 11-18 are welcome to join.
They meet every Monday evening 7:00-8:30 pm
in the Meguiar Youth Center (Room 134, Lower Gilmore Hall).
For More Information:
Jeanne Wurm
AHG Oath: "I promise to love God, cherish my family, honor my country and serve in my community."
American Heritage Girls is a Christ-centered scouting program for girls in Kindergarten through 12th grade. The AHG program seeks to develop the whole child – physically, mentally, and spiritually. Girls earn badges doing age-appropriate activities in diverse areas of interest such as Outdoor Skills, Family Living, and Science and Technology. Additional activities include camping, community service, patriotic salutes, and father-daughter events. AHG also stresses the importance of service to the community through several projects including participating in the annual Make a Difference Day.


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Find records of Gracie Williams
Find birth, death, marriage, military, and other records of Gracie D Williams at Ancestry.com.Search for records
Biography & Family History Add details
Gracie D Williams (1913 - 1995) was born on November 25, 1913. She was born into the Williams family.
There are no known marriages or children on file for Gracie. Gracie died on September 27, 1995 at 81 years old.
Gracie D Williams's last known residence is at Merced, Merced County, California.
We were able tofind a death record for Gracie D Williams in the United States Social Security Master Death Index (SSDI). What is the SSDI?
This look at Gracie D Williams's history is a collaborative effort by AncientFaces members Share what you know to connect with the people who know her. Some common things we would like to know about Gracie's genealogy:
- Where was Gracie born?
- Where did Gracie die?
- Who was Gracies family?
- What did Gracie look like? Add some photos of their life.
Family Tree & Genealogy Add / Edit People
You can add or remove people from this genealogy by clicking here.
History of Gracie D Williams Add details
- Given name
- Gracie
- Surnames
- Williams family history
- Last Known Residence
- Merced, Merced County, California
- Born
- Death
- Gender
- Female
Do you know more about Gracie D Williams?
You can add details to this page and share Gracie's story.
Obituary Add details
No one has shared info on the obituary records of Gracie D Williams. You can add obituary information about Gracie D Williams by clicking "Add Details".
Discuss Gracie
Share your memories below with the rest of Gracie's family. We'll notify anyone else who is searching for Gracie of your message.
Find records of Gracie Williams
Find birth, death, marriage, military, and other records of Gracie D Williams at Ancestry.com.Search for records
Possible Relatives
- John Floyd Williams
- ·
- Sidney Johnson Williams
- ·
- Tina L. Williams
- ·
- Vern Williams
- ·
- Christian Williams
- ·
- Arthur Williams
- ·
- Julia Williams
- ·
- Terrinesha Williams
- ·
- Richard Williams
- ·
- Brendan Williams
- ·
- Arlene Williams
- ·
- Valencia Williams
- ·
- Honorah (Williams) Byrnes
- ·
- Barbara Williams
- ·
- Larry Lonnie Williams Jr.
- ·
- Gloria Williams
- ·
- Teyonna Letitia Williams
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- Lori Williams
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- Lula Williams
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- Elizabeth Gail Williams
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kwanloong wrote:the word goddess is misused in this argument.
Islander1 wrote:May i kindly ask you who bashed Janine at the during the stay in Vegas? She was bashed for the gown and that was about it...................
kwanloong wrote:the word goddess is misused in this argument.
ajsy0203 wrote:Did I use the word 'goddesses' incorrect? Why lots of forumers called some of the contestants in any international beauty pageants 'goddess'?
ajsy0203 wrote:For clarification:
Examples of 'goddesses' chosen by the forumers but failed to place in the top 15/16
2010: Trinidad & Tobago
2011: Malaysia, Greece, Peru
2012: Puerto Rico, Ecuador, Georgia
Underdogs make it to the top 5:
2010: Ukraine, Australia
2011: Brazil, Philippines (prior to the pre-pageant week), Angola
2012: Brazil, Australia (by some fans), Philippines (prior to the pre-pageant week), USA
Users browsing this forum: aw aw, Bing [Bot], Brighter, bukita, dayangku, Dranreb14, Eternalsunshine, Ian Stone, john2000doe, ricpinc88, Wojtek, Yahoo [Bot], ZhangZin and 131 guests
|© Missosology's International Pageant Coverages ©
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|Miss Asia Pacific World
|Miss Grand International
|Face of Beauty International
|Supermodel International
|Manhunt International
|Miss Supranational
|Miss Earth
|Miss International
|Miss World
|Miss Universe


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Landscape labourers wanted at Kew Green
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Blu Homes acquires SF-based Modern Cabana
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Prefabricated home maker Blu Homes Inc. bought Modern Cabana in San Francisco, which makes add ons for existing homes.
Blu Homes, which has offices in Waltham, Mass. and San Francisco, didn't say what it paid in this deal.
Modern Cabana, started in 2004, makes so-called "cabanas," which can be added onto existing homes usually without a permit. Blu Homes will start selling the structures -- which can typically be built "over the course of a weekend," next year.
Blu Homes, which closed a $60 million investment in September, has its own factory in a 223,600-square foot building finished in 1940 on the former Mare Island Naval Shipyard near Vallejo.
Bill Haney, who helped start Blu Homes, is its president.
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Inhibitors of cytokine synthesis in nonimmune, resident ocular surface cells are useful for treating dry eye disorders and other disorders requiring the wetting of the eye.
1. A method for the treatment of dry eye and other disorders requiring the wetting of the eye which comprises administering to a mammal a composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a cytokine synthesis inhibitor selected from the group consisting of mtiogen-activated kinase inhibitors; c-jun N-terminal kinase inhibitors; I-kappa kinase inhibitors; IL-1β synthesis inhibitors; TNFα synthesis inhibitors; Janus family tyrosine kinase inhibitors; signal transducers and activators of transcription inhibitors; and retinoid X receptor ligands.
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[0001] This application claims priority to U.S. Provisional Application, U.S. Serial No. 60/412,463, filed Sep. 20, 2002.
[0002] The present invention is directed to the treatment of dry eye disorders. In particular, the present invention is directed to the use of certain cytokine synthesis inhibitors in the treatment of dry eye and other disorders requiring the wetting of the eye in mammals.
[0003] Dry eye, also known generically as keratoconjunctivitis sicca, is a common ophthalmological disorder affecting millions of Americans each year. The condition is particularly widespread among post-menopausal women due to hormonal changes following the cessation of fertility. Dry eye may afflict an individual with varying severity. In mild cases, a patient may experience burning, a feeling of dryness, and persistent irritation such as is often caused by small bodies lodging between the eye lid and the eye surface. In severe cases, vision may be substantially impaired. Other diseases, such as Sjogren's disease and cicatricial pemphigoid manifest dry eye complications.
[0004] Although it appears that dry eye may result from a number of unrelated pathogenic causes, all presentations of the complication share a common effect, that is the breakdown of the pre-ocular tear film, which results in dehydration of the exposed outer surface and many of the symptoms outlined above (Lemp, Report of the National Eye Institute/Industry Workshop on Clinical Trials in Dry Eyes, The CLAO Journal, volume 21, number 4, pages 221-231 (1995)).
[0005] Practitioners have taken several approaches to the treatment of dry eye. One common approach has been to supplement and stabilize the ocular tear film using so-called artificial tears instilled throughout the day. Other approaches include the use of ocular inserts that provide a tear substitute or stimulation of endogenous tear production.
[0006] Examples of the tear substitution approach include the use of buffered, isotonic saline solutions, aqueous solutions containing water soluble polymers that render the solutions more viscous and thus less easily shed by the eye. Tear reconstitution is also attempted by providing one or more components of the tear film such as phospholipids and oils. Phospholipid compositions have been shown to be useful in treating dry eye; see, e.g., McCulley and Shine, Tear film structure and dry eye, Contactologia, volume 20(4), pages 145-49 (1998); and Shine and McCulley, Keratoconjunctivitis sicca associated with meibomian secretion polar lipid abnormality, Archives of Ophthalmology, volume 116(7), pages 849-52 (1998). Examples of phospholipid compositions for the treatment of dry eye are disclosed in U.S. Pat. Nos. 4,131,651 (Shah et al.), 4,370,325 (Packman), 4,409,205 (Shively), 4,744,980 and 4,883,658 (Holly), 4,914,088 (Glonek), 5,075,104 (Gressel et al.), 5,278,151 (Korb et al.), 5,294,607 (Glonek et al.), 5,371,108 (Korb et al.) and 5,578,586 (Glonek et al.). U.S. Pat. No. 5,174,988 (Mautone et al.) discloses phospholipid drug delivery systems involving phospholipids, propellants and an active substance.
[0007] Another approach involves the provision of lubricating substances in lieu of artificial tears. For example, U.S. Pat. No. 4,818,537 (Guo) discloses the use of a lubricating, liposome-based composition, and U.S. Pat. No. 5,800,807 (Hu et al.) discloses compositions containing glycerin and propylene glycol for treating dry eye.
[0008] Although these approaches have met with some success, problems in the treatment of dry eye nevertheless remain. The use of tear substitutes, while temporarily effective, generally requires repeated application over the course of a patient's waking hours. It is not uncommon for a patient to have to apply artificial tear solution ten to twenty times over the course of the day. Such an undertaking is not only cumbersome and time consuming, but is also potentially very expensive. Transient symptoms of dry eye associated with refractive surgery have been reported to last in some cases from six weeks to six months or more following surgery.
[0009] Aside from efforts directed primarily to the alleviation of symptoms associated with dry eye, methods and compositions directed to treatment of the dry eye condition have also been pursued. For example, U.S. Pat. No. 5,041,434 (Lubkin) discloses the use of sex steroids, such as conjugated estrogens, to treat dry eye conditions in post-menopausal women; U.S. Pat. No. 5,290,572 (MacKeen) discloses the use of finely divided calcium ion compositions to stimulate pre-ocular tear film production; and U.S. Pat. No. 4,966,773 (Gressel et al.) discloses the use of microfine particles of one or more retinoids for ocular tissue normalization.
[0010] Some recent literature reports suggest that patients suffering from dry eye syndrome disproportionately exhibit the hallmarks of excessive inflammation in relevant ocular tissues, such as the lacrimal and meibomian glands. The use of various compounds to treat dry eye patients, such as steroids [e.g. U.S. Pat. No. 5,958,912; Marsh, et al., Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjogren syndrome, Ophthalmology, 106(4): 811-816 (1999); Pflugfelder, et. al. U.S. Pat. No. 6,153,607], cytokine release inhibitors (Yanni, J. M.; et. al. WO 0003705 A1), cyclosporine A [Tauber, J. Adv. Exp. Med. Biol. 1998, 438 (Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2), 969], and 15-HETE (Yanni et. al., U.S. Pat. No. 5,696,166), has been disclosed.
[0011] The present invention is directed to methods for the treatment of dry eye and other disorders requiring the wetting of the eye, including symptoms of dry eye associated with refractive surgery such as LASIK surgery. According to the methods of the present invention, certain cytokine synthesis inhibitors are administered to a patient suffering from dry eye or other disorders requiring wetting of the eye. The cytokine synthesis inhibitors are preferably administered topically to the eye.
[0012]FIG. 1 shows the inhibition of hyperosmolarity-induced cytokine production from human corneal epithelial cells in vitro by SP-600125 and dexamethasone.
[0013] According to the present invention, inhibitors of cytokine synthesis by nonimmune resident ocular surface cells, including corneal and conjunctival epithelial and stromal cells, are administered to a patient suffering from dry eye. The compounds suitable for use in the present invention inhibit the synthesis of pro-inflammatory cytokines in nonimmune resident ocular surface cells by interfering with specific effectors of signaling cascades in these cells. Effectors of cytokine synthesis targeted for inhibition in the treatment of dry eye include mitogen-activated kinases (MAP kinase, p38 kinase), c-jun N-terminal kinase (JNK) and I-kappa kinase (IKK). Also, inhibitors of enzymes which convert precursors of the pro-inflammatory cytokines IL-1β (ICE, IL-1 converting enzyme) and TNFα (TACE, TNF-alpha converting enzyme) to the active species or inhibit the translation of cytokine mRNA provide dry eye therapy. Cytokines promote further synthesis of pro-inflammatory cytokines through activation of Janus family tyrosine kinase (JAK) and signal transducers and activators of transcription (STAT) and, therefore, inhibitors of JAKs and STATs provide treatment of dry eye. Inhibitors of activator protein-1 (AP-1) suppress cytokine synthesis in ocular surface cells and provide dry eye therapy. Additionally, ligands of retinoid X receptors (RXR) are known to suppress cytokine synthesis in epithelial cells and are suitable for use in the present invention.
[0014] The classes of cytokine synthesis inhibitors identified above are known. Inhibitors of MAP kinases (p38) include (5-(2-amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinyl)imidazole) [�SB-220025�]. Inhibitors of JNK include anthra[1,9-cd]pyrazol-6(2H)-one [�SP-600125�]. Inhibitors of ICE include pralnacasan (HMR3480/VX-740). TNF mRNA translation inhibitors include (D)Arginyl-(D)Norleucyl-(D)Norleucyl-(D)Arginyl-(D)Norleucyl-(D)Norleucyl-(D)Norleucyl-Glycine-(D)Tyrosine-amide,acetate salt [�RDP58�]. NFkB inhibitors include 2-chloro-N-[3,5-di(trifluoromethyl)phenyl]-4-(trifluoromethyl)pyrimidine-5-carboxamide [�SP-100030�], and triflusal. AP-1 inhibitors include SP-100030. RXR agonists include bexarotene.
[0015] Preferred cytokine synthesis inhibitors for use in the present invention are JNK inhibitors and AP-1 inhibitors.
[0016] According to the methods of the present invention, a composition comprising one or more of the specified cytokine synthesis inhibitors and a pharmaceutically acceptable carrier for topical ophthalmic administration or implantation into the conjunctival sac or anterior chamber of the eye is administered to a mammal in need thereof. The compositions are formulated in accordance with methods known in the art for the particular route of administration desired.
[0017] The compositions administered according to the present invention comprise a pharmaceutically effective amount of one or more of the specified cytokine synthesis inhibitors. As used herein, a �pharmaceutically effective amount� is one which is sufficient to reduce or eliminate signs or symptoms of dry eye or other disorders requiring the wetting of the eye. Generally, for compositions intended to be administered topically to the eye in the form of eye drops or eye ointments, the total amount of cytokine synthesis inhibitor will be about 0.001 to 1.0% (w/w).
[0018] Preferably, the compositions administered according to the present invention will be formulated as solutions, suspensions and other dosage forms for topical administration. Aqueous solutions are generally preferred, based on ease of formulation, as well as a patient's ability to easily administer such compositions by means of instilling one to two drops of the solutions in the affected eyes. However, the compositions may also be suspensions, viscous or semi-viscous gels, or other types of solid or semi-solid compositions. Suspensions may be preferred for cytokine synthesis inhibitors which are sparingly soluble in water.
[0019] The compositions administered according to the present invention may also include various other ingredients, including but not limited to surfactants, tonicity agents, buffers, preservatives, co-solvents and viscosity building agents.
[0020] Various tonicity agents may be employed to adjust the tonicity of the composition, preferably to that of natural tears for ophthalmic compositions. For example, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, dextrose and/or mannitol may be added to the composition to approximate physiological tonicity. Such an amount of tonicity agent will vary, depending on the particular agent to be added. In general, however, the compositions will have a tonicity agent in an amount sufficient to cause the final composition to have an ophthalmically acceptable osmolality (generally about 150-450 mOsm, preferably 250-350 mOsm).
[0021] An appropriate buffer system (e.g., sodium phosphate, sodium acetate, sodium citrate, sodium borate or boric acid) may be added to the compositions to prevent pH drift under storage conditions. The particular concentration will vary, depending on the agent employed. Preferably, however, the buffer will be chosen to maintain a target pH within the range of pH 6-7.5.
[0022] Compositions formulated for the treatment of dry eye-type diseases and disorders may also comprise aqueous carriers designed to provide immediate, short-term relief of dry eye-type conditions. Such carriers can be formulated as a phospholipid carrier or an artificial tears carrier, or mixtures of both. As used herein, �phospholipid carrier� and �artificial tears carrier� refer to aqueous compositions which: (i) comprise one or more phospholipids (in the case of phospholipid carriers) or other compounds, which lubricate, �wet,� approximate the consistency of endogenous tears, aid in natural tear build-up, or otherwise provide temporary relief of dry eye symptoms and conditions upon ocular administration; (ii) are safe; and (iii) provide the appropriate delivery vehicle for the topical administration of an effective amount of one or more of the specified cytokine inhibitors. Examples or artificial tears compositions useful as artificial tears carriers include, but are not limited to, commercial products, such as Tears Naturale�, Tears Naturale II�, Tears Naturale Free�, and Bion Tears� (Alcon Laboratories, Inc., Fort Worth, Tex.). Examples of phospholipid carrier formulations include those disclosed in U.S. Pat. Nos. 4,804,539 (Guo et al.), 4,883,658 (Holly), 4,914,088 (Glonek), 5,075,104 (Gressel et al.), 5,278,151 (Korb et al.), 5,294,607 (Glonek et al.), 5,371,108 (Korb et al.), 5,578,586 (Glonek et al.); the foregoing patents are incorporated herein by reference to the extent they disclose phospholipid compositions useful as phospholipid carriers of the present invention.
[0023] Other compounds designed to lubricate, �wet,� approximate the consistency of endogenous tears, aid in natural tear build-up, or otherwise provide temporary relief of dry eye symptoms and conditions upon ocular administration the eye are known in the art. Such compounds may enhance the viscosity of the composition, and include, but are not limited to: monomeric polyols, such as, glycerol, propylene glycol, ethylene glycol; polymeric polyols, such as, polyethylene glycol, hydroxypropylmethyl cellulose (�HPMC�), carboxy methylcellulose sodium, hydroxy propylcellulose (�HPC�), dextrans, such as, dextran 70; water soluble proteins, such as gelatin; and vinyl polymers, such as, polyvinyl alcohol, polyvinylpyrrolidone, povidone and carbomers, such as, carbomer 934P, carbomer 941, carbomer 940, carbomer 974P.
[0024] Other compounds may also be added to the ophthalmic compositions of the present invention to increase the viscosity of the carrier. Examples of viscosity enhancing agents include, but are not limited to: polysaccharides, such as hyaluronic acid and its salts, chondroitin sulfate and its salts, dextrans, various polymers of the cellulose family; vinyl polymers; and acrylic acid polymers. In general, the phospholipid carrier or artificial tears carrier compositions will exhibit a viscosity of 1 to 400 centipoises (�cps�).
[0025] Topical ophthalmic products are typically packaged in multidose form. Preservatives are thus required to prevent microbial contamination during use. Suitable preservatives include: benzalkonium chloride, chlorobutanol, benzododecinium bromide, methyl paraben, propyl paraben, phenylethyl alcohol, edetate disodium, sorbic acid, polyquaternium-1, or other agents known to those skilled in the art. Such preservatives are typically employed at a level of from 0.001 to 1.0% w/v. Unit dose compositions of the present invention will be sterile, but typically unpreserved. Such compositions, therefore, generally will not contain preservatives.
[0026] The preferred compositions of the present invention are intended for administration to a human patient suffering from dry eye or symptoms of dry eye. Preferably, such compositions will be administered topically. In general, the doses used for the above described purposes will vary, but will be in an effective amount to eliminate or improve dry eye conditions. Generally, 1-2 drops of such compositions will be administered from once to many times per day.
[0027] A representative eye drop formulation is provided in Example 1 below.
[0029] The above composition is prepared by the following method. The batch quantities of boric acid, sodium chloride, disodium edetate, and polyquaternium-1 are weighed and dissolved by stirring in 90% of the batch quantity of purified water. The pH is adjusted to 7.4�0.1 with NaOH and/or HCl. The batch quantity of the cytokine synthesis inhibitor as a stock solution is measured and added. Purified water is added to q.s. to 100%. The mixture is stirred for five minutes to homogenize and then filtered through a sterilizing filter membrane into a sterile recipient.
[0030] Inhibition of Hyperosmolarity-Induced Cytokine Production from Human Corneal Epithelial Cells in vitro.
[0031] The ocular tear film in dry eye is abnormally hyperosmolar, which is irritating to ocular surface cells. Treatment of human conjunctival epithelial cells with a hypertonic media elicits the production of pro-inflammatory cytokines. A selective JNK inhibitor, anthra[1,9-cd]pyrazol-6(2H)-one, was evaluated for inhibition of hyperosmolarity-induced cytokine secretion from the transformed human corneal epithelial cell line, CEPI-17. CEPI-17 cells were grown in complete isotonic Keratinocyte Growth Medium (iso KGM) and plated in 48-well plates in iso KGM without hydrocortisone (iso KGM-HC). When the cells reached confluence, they were pre-treated for 1 hour with the compound at the indicated concentration in iso KGM-HC. The cells were then stimulated by hypertonic KGM-HC for 6 hours (additional 80 mM NaCl added in iso KGM-HC) in the presence of the compound. Aliquots of the supernatants were assayed for IL-6, IL-8 by ELISA. Cytokine release was normalized by the amount of double stranded DNA (dsDNA) extracted from the cells. Percent inhibition of cytokine production was calculated by comparison with cytokine levels in vehicle-treated cells. The results are shown in FIG. 1. Hyperosmolarity significantly induced IL-6 and IL-8 production from CEPI-17 cells under the conditions described. Dexamethasone significantly inhibited secretion of each cytokine at 100 nM. Anthra[1,9-cd]pyrazol-6(2H)-one (SP-600125) dose-dependently inhibited both IL-6 (IC50=12.6 μM) and IL-8 (IC50=3.7 μM) production.
[0032] This invention has been described by reference to certain preferred embodiments; however, it should be understood that it may be embodied in other specific forms or variations thereof without departing from its special or essential characteristics. The embodiments described above are therefore considered to be illustrative in all respects and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description.
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