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Venkatakrishna Rao Jala, Ph.D.
Venkatakrishna Rao Jala, Ph.D.
Ph.D., 2001, Indian Institute of Science, Bangalore, Biochemistry/Molecular Biology
Address: CTRB, Room 323
Research Interests
The G-protein-coupled receptor (GPCR) represent a large super family of seven treansmembrane-spanning proteins comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. GPCRs are instrumental in the transmission of a wide range of chemical messages from the extracellular environment to the interior of the cell. GPCRs have been implicated in a wide range of disorders including allergies, cardiovascular dysfunction, depression, obesity, cancer, pain, arthritis, diabetes, AIDS and various central nervous system disorders.
1. Elucidating the signal transduction pathways of estrogen-GPR30 (novel estrogen binding receptor) and understanding their structure-function relationships in invitro and invivo models.
Estrogen (17beta-estrodiol, E2) is an ovarian steroid hormone essential for the growth of both normal and transformed epithelial cells during pregnancy. Estrogens are also known to promote various types of cancers including breast, endometrial cancer and ovarian cancers. Estrogen mediates its effects through two well characterized nuclear receptors, estrogen receptor a (ERalpha) and estrogen receptor b (ERbeta). Tamoxifen, a selective ER modulator (a selective antagonist for ERalpha) is a widely used drug to treat breast cancer. However, long term use of the drug leads to several complications including increased risk of developing endometrial and lung cancer. It has been observed that 1 in 4 patients do not respond to tamoxifen despite being positive for ERs. There is now considerable evidence to suggest that some of the estrogen actions are independent of ERalpha and ERbeta. Recent discovery of GPR30, which suffices the membrane actions of E2 (also known as DRY12, FEG-1, LERGU, LyGPR, CMKRL2, LERGU2 and GPCR-Br) adds further complexity to estrogen biology. The role of this receptor has been implicated in several cancers, including breast, ovarian, endometrial and thyroid cancer. Our interests are to determine the structure-function relationships of estrogen-GPR30 and their role in development of lung cancer.
Collaboration projects with Prof. Haribabu Bodduluri:
2. Elucidating the role of chemokine receptors in the development of inflammatory diseases including atherosclerosis, arthritis and cancer.
The chemokines (chemotactic chemokines) are a family of small proteins or lipids known for their ability to control cell migration in the body. Their receptors belong to the class A subfamily of G protein-coupled receptors. In recent years, chemokines and their receptors have grown in importance, because they are involved in inflammation and autoimmune diseases, includes AIDS, atherosclerosis, arthritis, cancer and asthma etc. Chemokines and their receptors are now known to play a crucial part in directing the movement of mononuclear cells throughout the body, engendering the adaptive immune response and contributing to the pathogenesis of a variety of diseases. Chemokine receptors are some of the most tractable drug targets in the huge battery of molecules that regulate inflammation and immunity. Our interests include, determining the structure-function relationships of leukotriene receptor 1 and 2 (BLT1 and BLT2) and D6 chemokine receptors (Decoy) and their in the development of atherosclerosis, arthritis and cancer usingin vitroandin vivomodels. We recently started looking at role of inflammation in colon cancer development and modulation of microbiome in a host dependent manner.
3.Host-Microbiota interactions in colon cancer and diabetes:The complex nature of the humangut microbiotaand its relevance to human health and disease is at an early stage of investigation. It is becoming very clear that changes in the environment, diet and genetic factors greatly influence human microbiota contributing to the modulation of disease progression. We have identified the major role of microbiota and one of the GPCR called leukotriene B4 receptor1 (BLT1) in controlling colon cancer development in pre-clinical models in collaboration with Dr. Bodduluri. There are some epidemiological evidences to suggest the relationships between colon cancer and diabetes. However, there were not many efforts were dedicated to understand the molecular mechanisms or development of the pre-clinical models to study these inter-relationships. Despite knowing the role of microbiota in these disease conditions separately, there were no studies reported until now to examine the influence of host and environmental factors in these disease models. One of my major interests include understanding the influence of gut microbiota in the development of inflammatory disorders (colon cancer and diabetes) and the role of host or disease in modulating/reshaping the gut microbiota or vice versa, i.e., to define cause or consequence. We adopted and improvised the complete protocols to perform microbial sequencing on Roche 454 Jr Sequencing platform as well as metagenomic analysis at University of Louisville. We have completed several microbiome projects in collaboration with several groups. To list some of these include, but not limited to (a) determine the differential microbiome pattern between various ethinc groups (Caucasian, African-American, American-Indian) to identify the disease susceptible status based on microbiota patterns and (b) identification of small amounts of lung pathogens in infectious disease from nasal and nasopharyngeal swabs.
1. Jala, V.R.*,Radde, B.N., Haribabu, B., and Klinge, C.M. 2012. Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer. BMC Cancer 12:624.
2. Kakar, S.S.,Jala, V.R.,and Fong, M.Y. 2012. Synergistic cytotoxic action of cisplatin and withaferin A on ovarian cancer cell lines. Biochem Biophys Res Commun 423:819-825.
3. Cai, Y., Shen, X., Ding, C., Qi, C., Li, K., Li, X.,Jala, V.R.,Zhang, H.G., Wang, T., Zheng, J., et al. 2011. Pivotal role of dermal IL-17-producing gammadelta T cells in skin inflammation. Immunity 35:596-610.
4. Spite, M., Hellmann, J., Tang, Y., Mathis, S.P., Kosuri, M., Bhatnagar, A.,Jala, V.R., and Haribabu, B. 2011. Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity. J Immunol 187:1942-1949.
5. Jala, V.R.,and Haribabu, B. 2010. Real-time imaging of leukotriene B(4) mediated cell migration and BLT1 interactions with beta-arrestin. J Vis Exp
6. Mathis, S.P.,Jala, V.R.,Lee, D.M., and Haribabu, B. 2010. Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis. J Immunol 185:3049-3056.
7. Nasser, M.W., Raghuwanshi, S.K., Grant, D.J.,Jala, V.R., Rajarathnam, K., and Richardson, R.M. 2009. Differential activation and regulation of CXCR1 and CXCR2 by CXCL8 monomer and dimer. J Immunol 183:3425-3432.
8. Salogni, L., Musso, T., Bosisio, D., Mirolo, M.,Jala, V.R.,Haribabu, B., Locati, M., and Sozzani, S. 2009. Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14. Blood 113:5848-5856.
9. Jala, V.R.,Shao, W.H., and Haribabu, B. 2005. Phosphorylation-independent beta-arrestin translocation and internalization of leukotriene B4 receptors. J Biol Chem 280:4880-4887.
10.Jala, V.R., and Haribabu, B. 2004. Leukotrienes and atherosclerosis: new roles for old mediators. Trends Immunol 25:315-322.


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Originally written on Fox Sports Southwest | Last updated 11/16/14
Now that the season for the Texas Rangers has been over for almost a week and a lot longer in some peoples minds its time to hand out the report cards for the players. My grading system is simple. As go to those who had excellent seasons, Bs to those who were above average, Cs to those who were average, Ds to those below average and Fs to those either need to give back the money they were overpaid or find a new city to play in. There will also be some incompletes handed out for those who didnt see enough time to be fairly graded or had their season end because of injuries. There will be no plusses or minuses given because that makes my head hurt. Today well focus on the pitching. Tomorrow its the position players. A RHP Yu Darvish Sure he didnt win 20 games like some in the Japanese media expected but he was in the rotation from day 1 and won 16 games, struck out more than 200 batters and started the teams lone playoff game. He got stronger down the stretch. The biggest a...
Original Story: http://www.foxsportssouthwest.com/10/...
PLAYERS: Yu Darvish, Koji Uehara, Matt Harrison, Joe Nathan, Alexi Ogando, Ryan Dempster, Mike Adams, Tanner Scheppers, Derek Holland, Michael Kirkman, Martin Perez, Scott Feldman, Yoshinori Tateyama, Roy Oswalt, Mark Lowe, Colby Lewis, Neftali Feliz, Justin Grimm, Wilmer Font
TEAMS: Texas Rangers, Chicago Cubs
TEAMS: Texas Rangers, Chicago Cubs
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subset: commoncrawl


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Opeth Premiere New Music Video for "The Devil's Orchard"
Opeth Premiere New Music Video for "The Devil's Orchard"
Check out the new music video from Opeth, directed by New York City-based photographer Phil Mucci.
Opeth have just premiered their new music video for "The Devil's Orchard." You can watch the video, which was directed by New York City-based photographer Phil Mucci, below.
"The Devil's Orchard" is taken from the band's latest album, Heritage, which was released earlier this week on Roadrunner Records.
I was fortunate enough to catch the band live last night at Webster Hall in New York City, and while my interview with Mikael Akerfeldt was pushed back til next week, the band put on one hell of a show. You'd be wise to check out the band's upcoming tour dates here and try to make it out to a city near you!
You can check out a few shots from the show under the video.
Photo Gallery: Opeth at Webster Hall
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Painting Coconuts, goes behind the scenes of the Audi Quattro Experience – a one-of-a-kind interactive installation that put participants in the driver's seat of a custom-made 1 to 32 scale Audi A4 to test their on-track skills using the world's first iPad enabled slot car controller.
Captured through the eyes of track maker David Beattie of Slot Mods USA, the film offers a unique look into his personal story, passion for the art of custom track design and the sport of slot car racing. It also delves into the process and challenges his team faced to execute a project with so many innovative features. It's a testament to the commitment a man can have to his passions, Beattie's own personal mantra of "Painting Coconuts" is something every guy should consider when thinking about what he wants to spend his days doing.
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With a splitzerThis photo was shot on film. Taken by hodachrome with a Lomo LC-A+ (available in our Online Shop) loaded with Redscale 800(handmade) film in Gifu, Japan. These tags describe this photo: tree, multiple-exposure, multiple exposure, double exposure, doubles, double-exposure, double, and redscale. Date: 2012-10. Time: Morning. This photo can also be found in the album Redscale 2012 November.
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My unknown father
Since I have joined the team at Microsoft Canada, there is a running gag about Damir being my dad: you have to admit that the resemblance is troubling. A couple of months ago, I made a t-shirt for myself saying that Damir is not my father. On the last TechDays tour, I thoughts that it... Read more


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Apple refreshes iMac with Thunderbolt, Sandy Bridge
Apple has indeed taken the wraps off updated iMacs, as anticipated by rumour and a temporary Apple Store closure this morning. The new models - two 21.5in machines and a pair of 27-inchers - sport Intel Sandy Bridge chippery: 2.5, 2.7, 2.7 and 3.1GHz quad-core Core i5s, respectively. Build-to-order buyers can elect to have 2. …
Thunderbolt > Displayport
Thunderbolt isn't essentailly just Displayport. What Thunderbolt has is a backward compatibility mode where chips will drop back to Displayport mode if the only thing they see is a display. What Thunderbolt is, is encapsulated PCIe. In a sentence, you take all the good ideas from Firewire: hot plug, dynamic reconfiguration, peer to peer communication, isocronous transport, and use it to wrap around a PCIe lane or two as payload. Pretty much exactly the best of all worlds.
This means some pretty interesting things can happen. One of the neat tricks is that Thunderbolt is not difficult to port a peripheral to. A PCIe lane pops out at each end, and all the work done on previous device drivers should be trivially ported. Amongst other things it neatly subsumes the role that Express slot had. But better.
Don't forget
It's also full-duplex, whereas serial connections (like SATA and USB) are still half-duplex. Apple did a great thing and starting stuffing this chippery on their boards. Intel did a FAIL thing and didn't include this tech into their CPU/chipset in lieu of USB3, and instead decided to just shun USB3, leaving out LightSpeed(Thunderbolt) for now, instead. I would have loved to have a LightSpeed-capable external raid box (think NAS).
Takes all the fun out of peripherals...
...I really miss my SCSI chain
SCSI, not so scuzzy at all
SCSI was great, all the good computers came with it as standard, so that's Macs and Amigas.
The PC world had to endure bi-directional parallel ports for many things or fit a SCSI card and spend a lot more on hardware.
The first CD writers for IDE were notoriously shite.
I miss my scsi
Yes, I have kept my old dual 1GB cpu systems (remember them? 2 cpu & 2 fans on the same motherboard) and 4 SCSI 1500 rpm hard drives, running raid 0. and don't forget the "Knight Rider" lights in the raid card. Now all we have is a very small port in the side of your computer how times have changed.
Ah, those 50 wire ribbon cables, LUN number DIP switches, and SCSI terminators. Those were the days.....
Even better were the days before Keyed Cables
Ah yes, a SCSI cable plugged in upside down. The smell of burnt plastic and ash floating down through the air. Who needs this new fangled technology crap! Bring back the fry em hard days!
So with the Australian dollar running 10% above the US
Here I was thinking we might get dollar for dollar parity on new Mac prices...
But no, still a 10-15% charge (after removing GST) for the privilige of letting US customers pay less and get get a far higher level of service.
Gee, thanks Apple
Cost of Business
Australia lets companies import duty free?
Apple computers are built in the US?
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Stateside commissaries reopen
- 10/7/2013
Most AF civilians to return to work
Posted 10/7/2013 Updated 10/7/2013
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by Tech. Sgt. Vanessa Kilmer
Air Force News Service
10/7/2013 -
-- In accordance with a memo Defense Secretary Chuck Hagel released Oct. 5, the Air Force will recall most of the nearly 104,000 Air Force civilian Airmen placed on emergency furlough due to government shutdown. However, a significant number will not yet be able to return.
In his memo, Hagel stated that immediately after President Barack Obama signed the Pay Our Military Act into law, he directed DOD's Acting General Counsel to determine whether he could reduce the number of civilian personnel furloughed due to the shutdown.
After consulting with attorneys from the Department of Justice and the Department of Defense, the secretary said the Pay our Military Act does not permit a blanket recall of all civilians.
However, he said, DOD and DOJ attorneys concluded that the law does allow the DOD to eliminate furloughs for employees whose responsibilities contribute to the morale, well-being, capabilities and readiness of servicemembers.
According to DOD guidance for implementation of the Pay our Military Act, in addition to already excepted civilians, civilian Airmen who contribute to the morale, well-being, capabilities, and readiness of service members should also be removed from furlough status. Previously furloughed employees that fall in this category will return to work beginning Monday. Upon return to work, they may only perform "excepted" duties which encompass those duties necessary for the protection of life and property, so there will continue to be ongoing impacts due to the government shutdown.
"You've heard that we are bringing back many of our civilian teammates, but a significant number of them will not return. That is not what we or OSD wanted; however, the DOJ/OMB/DOD negotiated position on the interpretation of the law does not eliminate furloughs all together and leaves many of our civilian Airmen left behind," said Acting Secretary of the Air Force Eric Fanning. "Everyone's work supports our Airmen, but the mechanics of the legislation is the driving force of who comes back, not the value of the work. This is unfair and simply a disruptive situation for you and your families. From day one, our primary focus has been to rapidly get as many people back to work as soon as possible; and we will continue those efforts. We are a team, a family -- always have been. We will not be a fully-functioning organization until the last member returns."
Today supervisors began notifying Air Force civilian employees who will return to work next week. The Air Force is utilizing all possible means of communication including supervisor contact, social media, Air Force Personnel Center and AF.mil.
For current government shutdown information, visit AF.mil's Government Shutdown page, the Air Force Portal and/or contact the Air Force Personnel Center Total Service Center at 800-525-0102.
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Town Square
Juventus Strikers 90 boys soccer team are US Club Regional Champions
Original post made by suzanne brownstein, Menlo-Atherton High School, on Jun 26, 2007
The team is comprised of players from various ethnic and economic backgrounds.
Several of the boys attend Menlo Atherton High School, Woodside High School and Sequoia High School. All of the boys aspire to play Division I college soccer. Many of the boys will be the first in their family to attend college. Over 250 college coaches will be in attendance at the National Cup Finals.
The cost of the trip is beyond the means for many of the players and they have less than 4 weeks to raise funds to help subsidize the cost of this trip. In the past the boys have held raffles to raise funds, but there is little time organize a raffle. The Juventus Sport Club is based out of Redwood City and is a non profit organization. The team is looking for any size sponsorship to help defray the cost of this trip to North Carollina.
Email firstname.lastname@example.com for donation/sponsor information.
The players are Adam Brownstein, Nicholas Carrara, Juan Espinoza, Leonel Gutierez, Brady Jimison, Cole Kelly, Josh Leandro, Kian Malek, Ignacio Martinez, Ulysis Milanes, Alfonso Molina, Cesar Molina, Jose Nava, Carlos Ramirez, Jesus Resendiz, Julian Soto, Christian Valdez, Neil Watters and Oscar Yniguez.
Coaches are Jaime Frias, Apolonio Perez and John Carrara.
Here is the link to U.S. Club Soccer, which gives more info on the tournament: Web Link .
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Added Jul 30, 2008
by goosfabba
Belfast, Ireland
Okay my first attempt at sewing and im sitting there with 'the sewing encyclopedia' on the roller shelf of my desk. Dart, dart? dart dart dart, ah how to sew a dart. I have so far to go but i guess its a start. Its a little puckery or something at the front. Tips/advice would be supoib.
Fabric- Somerset Jinny Beyer
Aug 3, 2008, 12.23 PMby grammyweezy
not a bad skirt! darts are tricky…your house looks beautiful!
Jul 30, 2008, 05.07 PMby clairegeit
I guess the puckery is the bubble of the dart? Mainly it just practise for darts and you will get less of it, The best way is at the end of the dart instead of stopping sewing, sew a few small stiches right on the end fold of the dart. Then instead of stopping the machine let it "sew-off" the end of the dart so you pull the fabric from under the foot while the machine is still going this will give you a tail of thread to knot. Then just iron the S*%T out of them. These should help the 'puckery' at the end of the darts.
Jul 30, 2008, 03.54 PMby hannahlee
Great fabric. I love your top, too!
Jul 30, 2008, 03.32 PMby goosfabba
Thanks. I know i know im a right mothertucker, i seriously tuck everything in, luckily its never got to trousers being tucked into socks though (now that would be the day)
Jul 30, 2008, 09.35 AMby reneebeth
If this was your first attempt at sewing, then you're already off to a really great start with that amazing fabric! I'm a sucker for florals. Yeah, I think the "puckery" is the dart, there to give your hips a little wiggle-room but tuck the waist in?
Jul 30, 2008, 08.12 AMby easbrooke
Ummm . . . I'm guessing the darts is what you're referring to as "puckery." I think you did well for your first try. If you don't like the "puckery," you could try an A-line skirt instead or something else without any darts.
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I work in an oncology unit. Recently, two of my patients had what I thought were clearly written advance directives. But their physicians disagreed with family members about how to interpret these patients' last wishes. Our hospital's ethics committee helped resolve the situations, but now I'm confused. Don't we always need to follow a patient's advance directive?-T.R., KAN.
Most states recognize two types of advance directives: the living will and the durable power of attorney for healthcare. The living will states what life- sustaining treatments a patient wants or doesn't want if she can't express her wishes. However, deciding what conditions meet these criteria can be open to interpretation. Would a severe stroke meet the criteria, for example? The durable power of attorney for healthcare allows a person named by the patient to make medical decisions in her best interests when she can no longer make her treatment wishes known.
Ideally, these two documents complement each other-but sometimes they conflict. Perhaps a spouse who's experiencing significant anticipatory grief simply refuses to stop treatment despite the patient's previously expressed wishes. Even though this decision contradicts the patient's living will, the spouse with durable power of attorney for healthcare may have the last word. When the patient's healthcare providers have a different interpretation of her wishes than the spouse, referring the case to the hospital ethics committee is appropriate.
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Library expands campus access to 3D printers
The 3D Lab, part of the University of Michigan Library's Digital Media Commons on north campus, is expanding campus access to 3D printers thanks to a grant from the university's Third Century Initiative.
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The 3D Lab, part of the University of Michigan Library's Digital Media Commons on north campus, is expanding campus access to 3D printers thanks to a grant from the university's Third Century Initiative.
Interested in submitting an article to an open access journal, but not sure which one to choose? Or maybe you've already published something, and you'd like to know how you can share it with the world. Learn about all this and more during an informal Q&A with open access experts.
Compositions of voice, words, song, and environmental sounds combine with personal stories and images of Nichols Arboretum to inspire reflection on how outdoor experience and a sense of "place" influence personal meanings of home.
A collection of American culinary history: cookbooks and other materials from the 16th through the 20th century
We are not just what we eat, but how we eat — not to mention when, where and with whom. Cookbooks, menus, advertisements, manuals of table etiquette and the like may not be written to preserve the history of everyday life, but that's exactly what they do.
And this is what makes the library's Janice Bluestein Longone Culinary Archive so valuable. Containing more than 15,000 items, it paints a rich and unique portrait of American life over the centuries.
"On one level, the collection is about what people cooked and ate — but that's just a doorway to explore how people saw themselves and their neighbors," says collection curator JJ Jacobson.
Through the culinary archive one can explore changing attitudes towards diet and health, homemaking, commercial dining and the industrialization of food production. It also reveals historical ideas about race, class, and gender.
"This is the kind of history that's not concerned so much with empires, kings and battles, but with where the wheat comes from, how the bread is made, how ethnic groups adopte each others recipes, and what their cultures tell women and men they should be like," Jacobson adds.
And food continues to be an important part of our culture — contemporary discussions about organic produce, fast food, Atkins and other diet fads, concentrated feed lots, vending machines in schools and the merits of vegetarianism all stem from historical contexts chronicled in the archive.
The collection is shaped by the donation of a rich assemblage of cookbooks, menus, and other material collected over many years by Jan Longone, an adjunct curator in the U-M Special Collections Library, and her husband Dan.
Not so long ago, even the concept of American culinary history was met with skepticism.
"[Critics] said America had no cuisine or culinary history to speak of; all we ate were hamburgers," Jan Longone wrote of attitudes at an Oxford University food symposium in the 1980s. Yet today the archive is recognized as a premier collection for the study of American culture as it relates to food and home life.
Writing in the Boston Globe, renowned chef James Beard called an exhibit of works from the collection "an unequaled feat of culinary scholarship."
"Not all the cookbooks are good cookbooks, but they are all interesting and the authors, mainly women, were an amazing group who did a great deal to influence American history," Beard wrote in the 1984 column.
And the collection has only continued to grow and evolve since then. Formerly held at U-M's William L. Clements Library, it was transferred to the U-M Library in 2013 where its potential for teaching and scholarship can be fully realized.
The University of Michigan 3D Lab (the library!) is offering a series of Digital Creators Collective workshops to the university community.
Join us in Bert's Study Lounge to kick off the University Musical Society (UMS) season and celebrate the latest donation by Bert Askwith.
Bert Askwith, 102-year-old Class of '31 U-M alumnus from NYC and the donor who made possible the Askwith Media Library, Bert's Cafe, and Bert's Study Lounge, has made a generous donation to the class of 2017.
Presented in conjunction with the Ann Arbor District Library, All Hands Active, Ann Arbor Game Makers Meetup and WolverineSoft, the Oculus Rift Hackathon is your chance to experience the dream of the 90's and the biggest thing in gaming right now.
The opening of the Imaging the Dream exhibit begins with a talk by Georgetown University Professor Michael Eric Dyson in Chesebrough Auditorium, followed by a ribbon-cutting and reception in the Atrium of the Duderstadt Center.
Love the library? Join us in building the future of learning.Give to the Library
Except where otherwise noted, this work is subject to a Creative Commons Attribution 4.0 license. For details and exceptions, see the Library Copyright Statement.


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SURVEY: Do you oppose or support the Great Lakes Water Authority?
The newly-created Great Lakes Water Authority will soon control the regional system of the Detroit Water and Sewerage Department. ...Read more ›
The newly-created Great Lakes Water Authority will soon control the regional system of the Detroit Water and Sewerage Department. ...Read more ›
Week 76 of the Occupation of Detroit By Shea Howell Special to The Michigan Citizen Governor Rick Snyder, his Emergency Manager Kevyn Orr and the corporate interests who back them all breathed a sigh of relief last week as Syncora blinked. The bond insurer agreed to support the bankruptcy plan. David Heiman, a Jones Day attorney, told Judge Steven Rhodes these "passionate adversaries" have "laid down the s ...Read more ›
Researchers at EPI, a Washington, D.C.-based think tank focused on economic issues that effect low- and middle-income families, said employers steal wages from their workers by paying sub-minimum wages, failing to pay for overtime, writing bad payroll checks and cheating workers out of their tips. ...Read more ›
In his 1994 autobiography written with Lonnie Wheeler, "The Hard Stuff," Young warned Detroit about what the loss of the water department and other assets would mean for the city. The transfer of DWSD to a suburban authority signifies — as the transfer, outsourcing and outright sale of other city assets — a shifting, or transfer of power from Detroit, resulting in a redistribution of wealth. ...Read more ›
Many Detroit residents likely fell behind on their payments and couldn't get caught up after being blindsided by six years' worth of back sewerage charges that landed without warning or explanation in their mailboxes last year. ...Read more ›
Jayru Campbell needs prayer and treatment. Truth is, most feel Jayru had his chance, blew it and the hell with him. Those of us who truly pray cannot write off Jayru, but our numbers are few and dwindling. ...Read more ›
"Unless the governor's Transformation Manager can find someone else to blame for the problem by Monday, this misdemeanor "threatens to put Gov. Rick Snyder's administration on the road to ruin," the statement read. ...Read more ›
Nationally, the Republican Party has been criticized for leading a number of efforts that have made it harder for young people, poor and people of color to vote including enacting mandatory photo-ID among other regressive efforts. Be clear, the Republican Party is a minority and, according to polls, smaller than it has ever been before. ...Read more ›
The city does not need charity. We need solidarity. We, the people of Detroit, have for generations created imaginative, progressive solutions to our problems. We have turned vacant land into gardens and playgrounds, built communities out of vision and hope, and inspired world celebrated music, poetry, art and theater. ...Read more ›
By Steve Furay Special to the Michigan Citizen D-Town Farms' Eighth Annual Harvest Festival will take the city into the fall season once more. The event is scheduled for Sept. 20-21. Located at 14027 W. Outer Drive in Detroit, the festivities will take place on both days from 12-6 p.m., with live entertainment, educational seminars, learnshops and children's activities. Amid an urban agricultural movement i ...Read more ›
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Should I be taking both lisinopril and atenolol?
- Q: If I take lisinopril, does it do the same thing as atenolol? Should I be taking both medicines?
- A: The two medications, lisinopril and atenolol, may be taken together because they work in different ways to resolve your blood pressure or other conditions. Your physician may have you take both medications together to lower your blood pressure. Unless your physician has stated to you that one medication is replacing the other, you should continue taking the medications as prescribed. Lisinopril is in the class of medications called ACE inhibitors. ACE is a substance in the body that causes blood vessels to narrow, which increases blood pressure. Lisinopril works by blocking this substance, allowing for the blood vessels to relax and bring blood pressure down. Atenolol is in the class of medications called beta blockers. Beta receptors are found throughout the body, but mainly in the blood vessels and heart. Beta receptors are what stress hormones, like adrenaline, bind to to cause an increase in heart rate and blood pressure. Atenolol works by blocking the stress hormones from binding to the beta receptors. This allows for the blood vessels to relax, which brings blood pressure down and heart rate lowers. For more specific information on your medications, you should consult with your physician if you have any concerns or questions about taking these medications together. Lori Poulin, PharmD
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- V-Gan-25 for Allergic Reaction


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Jimmy Fallon Beats NASCAR Driver Jimmie Johnson!
Did you miss Jimmie Johnson on Jimmy Fallon? It was awesome!
Did you miss Jimmie Johnson on Jimmy Fallon? It was awesome!
Dale Jr. revealed his interesting back yard on Jimmy Kimmel Live.
The life style of celebrities has always interested us "normal folk" and Dale Jr.'s lifestyle is certainly interesting!
He seems like a "normal" guy
The Waltrip family name has been a part of NASCAR's top racing series for decades and now is headed from celebrating in victory lane to dancing in the ballroom.
With NASCAR's regular season coming to an end tonight at Richmond International Raceway we'll know the list of drivers who will be eligible to compete for this year's Championship.
The end of NASCAR races are usually the most exciting part of the race. This weekend's race was no different!
For the second week in a row, Kevin Harvick will start his Stewart-Haas No. 4 from the number one starting position.
Tony Stewart sat down in front of the press to talk about how he has reacted to the tragedy that happened just a couple of weeks ago when his car hit another driver, Kevin Ward, on a New York State dirt track. The tragic death of Kevin Ward has been heavy on the hearts of all race fans and clearly from the video I would say just as heavy on Tony as well.
Classic Country artist Wynonna will be part of the pre-race entertainment at tonight's NASCAR Sprint Cup Series race at Bristol Motor Speedway.
Carl Edwards has a new NASCAR racing team for the 2015 season!
Every year it seems the rules for the NASCAR chase change, this year is no different.
Who better to explain the rules to us than the drivers!! Take a look at this video explaining the new rules to the Chase
For the second week in a row, Jeff Gordon has set fast time in qualifying - this time at one of NASCAR's fastest tracks - Michigan International Speedway.
NASCAR driver Tony Stewart hit and killed another driver during an Empire Super Sprint car race at the Canandaigua Motorsports Park, according to local officials. Tony Stewart will not race in Sunday's NASCAR Sprint Cup race at Watkins Glen International.


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YHA Australia
Bookings & travel news
Hi there,
Hunter Valley YHA
100 Wine Country Drive
Nulkaba 2325
Phone: (+612) 4991 3278
Fax: (+612) 4991 3278
Manager: Nigel Worton
Email: firstname.lastname@example.com
Reception Hours:
8.00am - 12pm and 5pm - 8pm
exclusive use of the hostel, from $1200 per night mid week, and a 2 night minimum stay on weekends (extra charges apply).
Sydney - Train & Bus services available to Cessnock. Ring for a free pick up in Cessnock.
Newcastle - Buses depart four times per day to Cessnock. Ring for free pick up in Cessnock.
Maitland - Buses depart Maitland train station daily to Cessnock. Ring for free pick up in Cessnock.
30 km to Maitland Station. Please visit the CityRail website to plan your trip.
Nearest Airport:
30 kms to Newcastle Airport
Take Cessnock exit from Pacific Highway (aka F3 Sydney-Newcastle Freeway). From Cessnock follow tourist information and winery signs. Hostel is 2 km north of Cessnock.
Direct transfers and packages from Sydney available. Contact the hostel.
Once you have stayed with us you will be invited by email to provide your own rating of the hostel. The rating will be published, whether you give us good or bad marks.
Here are some of the satisfaction ratings we have received from previous guests:
Ask Colleen for the best advice for wine tours and do your research
Discover Australia's leading wine area, the Hunter Valley. Full day tour including lunch at Hope Estate. Visit two premier wineries plus tastings at boutique wineries.
Free beer and wine tasting + free Brewery Tour.
Ph: 02 4982 6411
Concession entry
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Port Stephens
Blue Mountains
YHA Travel licences: 2TA002629 (NSW), LTA148 (NT), 3433524 (QLD), TTA32 (SA), TA-0033055


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Leaving aside that some of his interpretation of the Evans article is a little skewed, it´s interesting that Mr. Moran completely misses his own hyperbole.I suppose if you want these kids chained to a dungeon wall somewhere and fed bread and water, that would satisfy some of these political Christians...Really? That´s what we want if we think that some of our politicians have made a mistake in entering this venue in this way?Mr. Moran does a nice job of painting those who want to focus on the underlying issue of how to stop this invasion as people who would make children suffer and ´punish´ them for how they got here by assisting in making their lives miserable.Perhaps he should follow his own advice regarding gleaning insight and impugning the motives of others.Since you seem to have so much trouble understanding the rational, Mr. Moran, let me spell out my thoughts for you. I have no quarrel with Mr. Beck offering a charitable service to people that he sees in need. However when our political representatives publicly involve themselves in this, it only adds to the governmental ´come on over, we´ll take care of everything´ message that brought this onslaught in the first place.No one is suggesting that these people, especially ´the children´ should be made miserable or denied basic human needs. But it´s a nice straw man.
Click Here if you Like this Comment 16 persons like this.
Is the same so called Christian Glenn Beck who plagarized Andrew Breitbart then viciously attacked him when called out on it?
Click Here if you Like this Comment 13 persons like this.
"... Dana Loesch who unleashed a flurry of hysterically exaggerated, ill-tempered tweets that were as baffling as they were inaccurate."Whatever one thinks of Evans´ article, Dana went off the rails on this, it became almost comical. She got a lot of support from the Twitterverse but I´ll tell you it came off as childish and petty after a while (to me), she just wouldn´t stop. She also blasted Breitbart for daring to reprint the article. I guess the lesson here is do not criticize or disagree with Dana Loesch. Ever.
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From the article: Immigrants add a lot to our society (not an exact quote)yes they do! Admit it everyone.here´s a partial list of what they add to our country/culture/societyRapemurderhuman traffickingdrunkennessDISEASE!!!millions and many millions of taxpayer dollars spent on care, incarceration,Feel free to add anything I didn´t list.
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Apparently the fight has continued, Evans has written another post in response to this post.I think Evans post was somewhat over the top. I have no problem with some humanitarian assistance for the children - which is not synonymous with "OK, let´s get these kids a home." Beck has clearly stated he wants these kids to then turn around and leave. But our systems are overwhelmed and he felt a need to help out. What´s the big deal about that, really?I don´t think it reveals any hidden democrat stuff. I think it brings a balance to our American stance that the Statue of Liberty says "give us your downtrodden....." and what is lawful. Give the kids some food, clean them up, let them recuperate and send them back.What they are doing has nothing to do with the kids that have already been shipped out, too soon, with various diseases.I think too many of us are getting way too emotionally distracted and not staying firm and calm as to what needs to happen. And Beck´s, and those with him, actions express the heart Americans have - but that we still hold to the rule of law.
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And who is M. Catharine Evans? I cannot find anything about her when I do a google search except for her articles on American Thinker.
Click Here if you Like this Comment 13 persons like this.


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Pathfinder Society Scenario #6–06: Hall of the Flesh Eaters (PFRPG) PDF
Liber Influxus Communis WIP (PFRPG) PDF
Dungeons & Dragons Fantasy Miniatures—Icons of the Realms, Set One
Pathfinder Battles—Lost Coast
Star Wars Fan Club Dinner Autographed Ticket
Paizo Publishing, LLC
This limited-edition ticket was given out to Star Wars Fan Club members who attended a special dinner event in Seattle during 2004. The guests were Amy Allen (Aayla Secura) and Michonne Bourriague (Aurra Sing). Only 70 of these tickets were made; each was autographed by both actresses. A few tickets were left over after the event, and so these are being offered to you here on paizo.com.
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Income tax preparation, bookkeeping Notary services, title transfers for motor vehicles, boats, ATV's, and snowmobiles. Replacements for Motor vehicle documents. Serving Palmyra and vacinity for over 40 years
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Stayed for 3 weeks in the budget section. Enjoyed the location near the jetty, where you can watch the Dolphins, and the fancy new foreshore. It is about a 20 minute walk to the centre of town. For the price, I felt the rooms were well supplied and cleaned. The staff were always friendly and helpful, and the cooking facilities... More
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1-10 of 78 properties for sale found
3 bed detached house for sale
2 bed flat for sale
White Hart Mews, High Street, Chipping Norton, Oxfordshire, OX7
£2,000,000 Offers in Excess of
Offers in Excess of £2,000,000
Land for sale Former Chipping Norton Memorial Hospital
**Site Open - Thursday 20th February - 2.00 p.m. to 3.30 p.m.** Excellent opportunity for redevelopment of a centrally located site of approx. 0.75 acre (0.30 hectare) within the well regarded settlement of Chipping Norton. Planning permission granted for the erection of 14 units. For Sale by I... More details ›
Plot for sale Church Lane, Chipping Norton, Oxfordshire, OX7
An opportunity to create a country house near Chipping Norton More details ›
£1,075,000 Guide Price
Guide Price £1,075,000
Commercial Property for sale Market Place, Chipping Norton, Oxon
A SUBSTANTIAL LISTED PERIOD TOWN HOUSE WITH GREAT POTENTIAL INCORPORATING A LET SHOP AND AN OUTBUILDING WITH CONSENT TO CREATE TWO DWELLINGS... More details ›
Reduced on 25/06/2014 by Tayler & Fletcher, Chipping Norton. Call: 01608 510026 Local call rate
£959,000 Guide Price
Guide Price £959,000
Detached house for sale Chipping Norton, Oxfordshire
Perfect Cotswold package with two dwellings, stunning views, added potential and first class local amenities. More details ›
£850,000 Guide Price
Guide Price £850,000
5 bedroom detached house for sale The Close, Salford, Chipping Norton, Oxfordshire, OX7
A modern house with views approaching 4,000 sq. ft. More details ›
- Photos: 1
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Land for sale Cromwell Park, Chipping Norton, OX7 5SR
A RARE DESIGN and build opportunity on a plot of land within Cromwell Business Park, with existing B1 PLANNING CONSENT for business related uses. Subject to the necessary planning consent, alternative employment uses outside of the existing B1 Business consent will be CONSIDERED. More details ›
Guide Price £725,000
4 bedroom detached house for sale Manor Gardens, West Street, Chipping Norton
ONE OF ONLY FOUR BRAND NEW HIGH SPECIFICATION HOMES - Hall with Oak staircase, cloakroom, sitting room, large living kitchen, vaulted garden/family room, utility, first floor master bedroom with ensuite guest bedroom with ensuite, two further bedrooms and family bathroom. Double garage, private g... More details ›
Added on 13/10/2014 by scottfraser, Witney. Call: 01993 655037 Local call rate
- Photos: 1
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Guide Price £725,000
Shop for sale 17 Market Place,Chipping Norton
A MIXED USE TOWN CENTRE PROPERTY COMBINING A PRIME RETAIL FRONTAGE INVESTMENT WITH DELIGHTFUL GEORGIAN TOWN HOUSE ACCOMMODATION AND A FURTHER LET FLAT More details ›
Marketed by Tayler & Fletcher, Commercial. Call: 01451 526027 Local call rate
Guide Price £725,000
Commercial property for sale Market Place, Chipping Norton
A MIXED USE TOWN CENTRE PROPERTY COMBINING A PRIME RETAIL FRONTAGE INVESTMENT WITH DELIGHTFUL GEORGIAN TOWN HOUSE ACCOMMODATION AND A FURTHER LET FLAT... More details ›
Added on 03/10/2014 by Tayler & Fletcher, Chipping Norton. Call: 01608 510026 Local call rate
£650,000 Guide Price
Guide Price £650,000
5 bedroom detached house for sale Over Norton Road, Chipping Norton
An Interesting Detached Residence offering Deceptively Spacious and Unique Accommodation backing onto Woodland with a High Degree of Privacy set in One Third of an Acre. More details ›
Added on 04/11/2014 by Mark David Estate Agents, Deddington. Call: 01869 714036 Local call rate
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- Northern Illinois to get $8.3 million for state construction projects
- Tree-lighting festival kicks off holiday season in Machesney Park
- Roscoe Boy Scout Troop's tree stand at new location
- Tips for selecting safe toys for kids this holiday season
- Prayer service for World AIDS Day Nov. 30
- Food Bank joins national #GivingTuesday movement
- Lee Hamilton: What lies ahead for Congress
- Rockford Public Schools faces $8.8 deficit, board OKs flat tax, HR chief
- Literary Hook: A holiday tradition: 'This Thanksgiving, Remember'
- Cold snap does not negate global warming
Wellstone death latest in long string
Wellstone death latest in long string
By Joe Baker, Senior Editor
Sen. Paul Wellstone, who was killed last week in a plane crash in northern Minnesota, was the number one enemy of Bush administration programs.
He voted against the war on Iraq; he voted against the Department of Homeland Security; he voted against the resolution giving President Bush expanded power to attack other countries; he voted against the Patriot Act: and he voted for an independent probe of the Sept. 11 attacks on the U.S.
It is well known that Bushs political helmsman, Karl Rove, had targeted Wellstone for defeat. He poured large amounts of money into Minnesota in support of a conservative Republican candidate.
In its May 27th edition, The Nation magazine wrote: Minnesotas senior senator is not just another Democrat on White House political czar Karl Roves target list, in an election year when the Senate balance of power could be decided by the voters of a single state. Rather, getting rid of Wellstone is a passion for Rove, Dick Cheney, George W. Bush and the special-interest lobbies that fund the most sophisticated political operation ever assembled by a presidential administration.
There are people in the White House who wake up in the morning thinking about how they will defeat Paul Wellstone, a senior Republican aide confides. This one is political and personal for them.
Despite all the pressure, Wellstone stood his ground and voted his principles. In casting his vote against the war, he declared: A pre-emptive, go-it-alone strategy towards Iraq is wrong. I oppose it. Three members of the U.S. House of Representatives also voted no on the war.
CNN reported that since 1972, there have been at least 12 prominent politicians killed in plane crashes. The previously most recent was Missouri Gov. Mel Carnahan in October of 2000. Carnahan also was running for the Senate and was a Democrat.
The others were: U.S. Commerce Secretary Ron Brown on April 3, 1996; South Dakota Gov. George Mickelson, a Republican, on April 19, 1993; Sen. John Heinz, Republican, of Pennsylvania on April 4, 1991; Sen. John Tower, R-Texas, on April 5, 1991; Rep. Larkin Smith, R-Miss., on August 13, 1989; Rep. Mickey Leland, D-Texas, on Aug. 7, 1989; Rep. Larry McDonald, Democrat of Georgia, Sept. 1, 1983; Rep. Jerry Litton, D-Mo., on August 3, 1976; Rep. Jerry Pettis, R-Calif., on Feb. 14, 1975; House Majority Leader Hale Boggs, D-La.; Rep. Nick Begich, D-Alaska, on Oct. 16, 1972; and Rep. George W. Collins, D-Ill., near Chicagos Midway Airport on Dec. 8, 1972.
Very recently,Illinois Republican Senator Peter Fitzgerald and several house leaders also had a close call over Missouri, when the pilots of their plane were concerned about a malfunction with their landing gear.


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StartUpHire is the place to find Manager, Client Proposals jobs. Review the list of Manager, Client Proposals career opportunities to the left. These Manager, Client Proposals jobs represent some of the most rewarding careers available.
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The Account Manager will support a wide range of responsibilities for the Account Management and Health Plan Sales teams. The position is split between managing existing client business and helping the team establish new client relationships. This is an ideal opportunity for10/13/2014 New York, NY Save This Job
Tracking Code 163-621 Job Description GetWellNetwork, Inc. provides patient engagement solutions that help health care providers engage, educate and empower patients along the care continuum. Our patient-centered platform, delivered across multiple technology platforms including10/13/2014 Bethesda, MD Save This Job
Reports to: Sr. Director, Business Development Operations Role: The Manager, Proposals and Contracts will provide support in the development and submission of contracts, quotes, bids and proposals for direct to customer deals and deals/opportunities through our partner10/11/2014 Horsham, PA Save This Job
Description The Business Development Manager, Small Business Services is responsible for developing new strategic client relationships in the region, focused on selling information technology professional services. PLA Small Business services offerings span IT Strategy, Managed9/30/2014 Sacramento, CA Save This Job
Description The Business Development Manager is responsible for developing new strategic client relationships in the Chicago region, focused on selling information technology professional services. PLA service offerings span IT strategy, software development, business9/30/2014 Southfield, MI Save This Job
Description The Business Development Manager is responsible for developing new strategic client relationships in the Boston area., focused on selling information technology professional services. PLA service offerings span IT strategy, software development, business9/30/2014 Wakefield, MA Save This Job
The Sr. Manager, Solutions reports to the Solutions Director and is an experienced team leader, digital native, and brand advocate who can effectively drive integrated marketing initiatives that calibrate clients? objectives with SAY?s ?best in class? editorial and media9/1/2014 New York, NY Save This Job
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Brief Description The Account Manager is primarily responsible for selling McLaren products and services to allocated new and existing customers or allocated territory/industry sector. This role is responsible for identifying and managing sales opportunities,10/21/2014 Houston, TX Save This Job
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Tracking Code 167-042 Job Description There?s a certain kind of energy here. You can feel it. It?s what happens when your job makes a tangible, positive impact for your clients, and our world. It?s what happens when you work with a team that?s all in, all the time. It?s what10/4/2014 San Diego, CA Save This Job
Category: Account Management Location/City: Atlanta, GA Are you one of those technically proficient and creative individuals who wish they?d had an opportunity to contribute to a major institution in its infancy? If you are, then we can?t wait to meet you! At Cardlytics,11/25/2014 Atlanta, GA Save This Job
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Location:Mesa, AZ Department:Marketing Posted:11-06-2014 Location Name:Mesa, AZ Wage:Depends on Experience Position Type:Full time Shift:Standard Edupoint Educational Systems, voted in 2013 and 2014 as a "Top Companies to Work For" is currently seeking an experienced, Marketing11/21/2014 Mesa, AZ Save This Job
Job Description Spinnaker is a focused supply chain services company that helps clients grow, manage risk, reduce costs, and improve customer service by developing world-class supply chain capabilities. Our services help clients develop the right supply chain strategy for their11/6/2014 Houston, TX Save This Job
Description Beecher Carlson is a large account risk management broker that delivers expertise by industry focus and product specialization. We strive to develop new and better technologies to support your business requirements and drive operational excellence. By leveraging our9/28/2014 Nashville, TN Save This Job
Outbrain is seeking an energetic, customer- and content-obsessed Account Manager for our New York office. The role involves building a new team in Outbrain, responsible for growing existing accounts. The Account Manager will be responsible for strategically identifying clients11/13/2014 New York, NY Save This Job
Spinnaker is a company focused returns management and returns management services that helps clients grow, manage risk, reduce costs, and improve customer service by developing world-class returns management capabilities. Our services help clients develop the right returns11/6/2014 Houston, TX Save This Job
Paid Media Services Managers are responsible for day to day management of smaller client accounts and will work with Senior Managers on larger accounts. Managers will not only be responsible for overseeing the Associate Managers on their accounts, but may also be assigned to10/11/2014 San Diego, CA Save This Job
Job Overview ZEDO is looking for a Publisher Account Manager who will play a key role in supporting our existing strategic publisher accounts.. The ideal candidate will have two key areas of responsibility: (1) Drive adoption of ZEDO High Impact Formats and (2) grow revenues from9/30/2014 New York, NY Save This Job


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Seeking funding? Here are 10 investors in India you should meet
Tech in Asia
We have seen investments into Indian tech startups on an upswing recently, topping US$1.3 billion in FY2013-14 and accounting for 266 deals. We're getting close to a deal a day. In fact, the first quarter of 2014 had a multi-year high of $427 million. While ecommerce took the lion's share, online travel and educational tech also attracted increasing interest from investors.
This is a continuation of a trend over the past five years. Between 2010 and 2013, more than US$3 billion flowed into India, which compares well with US$1.5 billion invested in Startup Nation Israel in the same period. This despite the fact that the Indian startup ecosystem is still not mature enough for big ticket exits, and over four-fifths of investment deals are early-stage.
So who are these early bird investors making big bets on Indian innovation? Who are the optimistic ones you should probably go to first if you're a startup looking for funding in India?
Silicon Valley-based 500 Startups tops the list. It was the most active institutional investor in the Indian tech startup scene in 2013-14, making over 20 investments during the year, according to research firm CB Insights. Mumbai-based Blume Ventures was second, while Accel Partners rounds out the top three.
Four out of the top 10 ranked investors are based in India — Blume Ventures, Kalaari Capital, IDG Ventures India, and Kae Capital. The others have their headquarters abroad, but most of them have a presence in India to keep track of emerging startups as well as their investments.
Here's a rundown of the top 10 institutional investors who have been the most active in the Indian tech startup scene recently:
500 Startups
Dave McClure's popular Silicon Valley based seed fund has been bullish on India, with a country-specific fund called 500 Wallah. It made as many as 20 investments in FY2013-14, into companies like price comparison site PriceBaba and language learning innovator CultureAlley. And it currently has three startups from India in the ninth batch of its accelerator program.
Blume Ventures
This Mumbai-based homegrown venture capital firm likes to take a collaborative approach to investing, roping in other investors and angels into the ventures it backs. Blumers they call themselves, but they have a number of successes under their belt. Cool startups like cab aggregator TaxiForSure and robot-maker Grey Orange are in the Blume basket.
Accel Partners
Investments in ecommerce biggie Flipkart and Myntra's series E, as well as BabyOye's US$12 million series B and real estate portal CommonFloor's series C and D rounds, among others, made Accel Partners one of the movers and shakers in India in the last four quarters. Freshdesk and BookMyShow are among the many Indian stars this California-headquartered firm has backed.
Kalaari Capital
Technopreneur-turned-investor Vani Kola, who returned to India after a billion-dollar exit from Silicon Valley, is the managing director of this Bangalore-based venture capital firm which took a punt on Snapdeal and Myntra long before the ecommerce boom. Kalaari, which derives its name from a martial arts tradition in South India, continues to pick winners like Urban Ladder and Zivame.
Tiger Global Management
This 'Tiger Cub' from New York has funded some of the tech pioneers in India like Flipkart, MakeMyTrip and JustDial. In fact, it was one of the early players in the Indian tech startup scene, before unexpectedly shutting shop in 2009, ostensibly because it did not find the scale it was looking for. But it has been back with a bang since 2011.


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Four Europe observers missing in Ukraine
Tuesday, May 27, 2014
VIENNA - The Organization for Security and Co-operation in Europe announced that they have lost contact on Monday with four of their observers who were serving in Donetsk, east of Ukraine.
The incident took place following the seizure of Donetsk airport, in which 35 pro-Russian separatists were killed.
The organization said in a written statement that communication was lost with four observers, among them a Turkish citizen, on Monday at 18:00.
Contact was lost while the group was on a routine mission in Donetsk, the statement said, and efforts to reach the group continue, it added.
The Organization for Security and Co-operation in Europe began a mission in Ukraine on 21 March, with 200 observers.
Copyright © 2014 Anadolu Agency
World News:
Blast rocks college in Nigeria's Kano; casualties feared
France: Six held over 'recruitment of female jihadists'
Death sentence overturned for Bangladesh Islamist leader
Polls show pro-Scottish independence gains
Ex-MP killed in clashes in Libya's Tripoli


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Not-for-profit pension plans
News and video about Not-for-profit pension plans from Pensions & Investments
Lawsuit by Girl Scout council dismissed
trueA federal appeals court dismissed a lawsuit against the Girl Scouts of the USA brought by a local council, ruling that member employers in multiple-employer defined benefit plans have little recourse under the Employee Retirement Income Security Act to challenge unilateral actions by plan sponsors.
Money managers create firm to cater to Catholic investors
trueSome big names in institutional investing have joined forces to provide Catholic-affiliated pension funds, endowments and other non-profit organizations with money management that follows the tenets of their faith.
Daughters of Charity Health System church plan challenged
trueAnother church-affiliated hospital system is being sued by employees challenging its defined benefit plan's exemption from federal pension law.
Research consortium to create pan-European pension fund
trueSeven research companies and universities have been named founding members for a new pan-European pension fund for researchers.
Church plan fiduciaries can be sued, U.S. judge says
trueFiduciaries of church-affiliated defined benefit plans can be sued for breach of duty, even if the plan has church plan status, a federal judge has ruled.
British Medical Association selects Buck as pension fund consultant
trueBritish Medical Association Staff Pension Scheme, London, hired Buck Consultants as investment consultant.
U.N. pension fund names top investment officer
trueCarol Boykin was named the top investment officer of the $52 billion United Nations Joint Staff Pension Fund.
The Pensions Trust takes interim tag off CEO
trueMichael Ramsey was appointed CEO at The Pensions Trust.
Keeping the PBGC from being the next bailout recipient
trueA series of recently issued reports have addressed various governance and financial challenges facing the Pension Benefit Guaranty Corp. The takeaway from all of them is that unless changes are made in the way the federal pension insurance system is governed and financed, there is a heightened risk ...
Church-plan status under increased scrutiny
trueA growing number of lawsuits and some key court rulings are making it harder for church-affiliated defined benefit plans to be exempt from the Employee Retirement Income Security Act.
Church pension plan status rejected by U.S. District Court
trueIn one of five major class-action lawsuits challenging church-affiliated sponsors of defined benefit plans, a federal judge ruled Tuesday that the pension plan of Dignity Health is covered by ERISA.
Slow process seen in naming Gotbaum successor at PBGC
trueJoshua Gotbaum's resignation as director of the Pension Benefit Guaranty Corp. is expected to create a leadership vacuum at a critical time for an agency dealing with struggling multiemployer pension plans and corporate defined benefit sponsors stressed about premium increases.
UConn CIO to join Hartford HealthCare as senior investment director
trueKevin Edwards was named senior investment director at Hartford HealthCare, according to David Holmgren, chief investment officer.
International Finance Corp.'s private equity head to retire
trueDavid Wilton will retire in about a month as chief investment officer and manager for global private equity for the International Finance Corp., a member of the World Bank Group.
Church of England looks to grow several asset classes
trueChurch of England's investment fund grew 11% to a record £6.1 billion ($10.3 billion) for the year ended Dec. 31.


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£400 pcm large double room to rent
Large double room with fitted wardrobes, large garden, buses every 15 mins into centre from the top of the road. Parking outside the house for a car, wireless internet. Double glazing, gas central heating. I am a nurse working at the BRI, I have a
- Date available: 01 Nov 2014
- 3 Beds
- House
- Agency


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Wednesday, November 26 – Closing at 1:00 pm due to snow forecast
Member of the Bergen County Cooperative Library System
Find books, movies, and music…
New For Children
"Page Turners" Book Club
"Page Turners" Book Club
Grades 3-4
Come and be a part of our new grades 3-4 "Page Turners" book club!
We will be meeting the first Thursday […]
Fall Storytime
Registration for the Fall Story Time sessions will start on Tues. Sept. 2nd, 2014. This may be done in person or by phone. Sessions […]
New For Teens
The Sorting Hat and Caramel Apples
Check out this new perspective on The Sorting Hat!
Thanks to Demarest Farm for the donation of apples for our Caramel Apple dipping station.
Ghosts & Hauntings – Teen book list
Let the Halloween countdown begin…
Check out this list of teen books featuring ghosts & hauntings if you dare!
On Exhibit – Ornaments by Nick Metz
Handcrafted Holiday Art – on display through November 31.
Nick Metz is a 15 year old sophomore at Pascack Valley High School, and has been […]
Book Displays
Orange you glad we've got books?
Check out our display of non-fiction books with ORANGE covers… interesting collection. Through October 31.
MakerSpace Activities
MakerSpace Wednesday – Pop-Up Cards
Wednesday, November 19 – 2:30 to 4:30 p.m. (ish)
We will be crafting pop-up cards. Children 8 and younger require their parent/guardian to assist.
card stock
construction […]
Thursday Book Group
Thursday Evening Book Club – January 15, 2015
This January we will be discussing Wild by Cheryl Strayed. In the wake of her mother's death, her family scattered and her own marriage […]


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Oh I know what you mean and I
Oh I know what you mean and I agree with you to an extent.
In the end, I'd rather see those "positions" disappear than attack the idea of dual-citizenship. Clearly, the Israeli lobby has far too much influence on American foreign policy. The great thing about Ron Paul's position, is that it undermines the lobby's efforts by attacking the philosophical and "legal" institutions that permit such exploitations.
"My theories explain, but cannot slow the decline of a great civilization. I set out to be a reformer, but only became the historian of decline."
- Ludwig Von Mises
- Login to post comments


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Norwegian Cruise Line Holdings Ltd. announces fleet expansion for Oceania Cruises in 2016; Sirena to join sister ships Insignia, Regatta and Nautica
Norwegian Cruise Line Holdings Ltd.
MSC Cruises has started a fleet-wide optimization installed by Marlink to improve shipboard VSAT (Very Small Aperture Terminal) connectivity. MSC Cruises said it
Fincantieri, the world leader in the construction of cruise ships, has signed two memorandums of understanding, respectively with Carnival Corporation, the world's largest cruise line,
Mariners do best when they avoid the edges of the sea – the shoals, rocks, and other hard spots. Coming into contact with the edges of the sea at other than a
Seafarers' Rights International (SRI) has raised concerns about the implications for masters of the recent reports of the launch of the new EU Frontex operation
The Coast Guard and Ocean Safety rescued two kayakers trapped on Molokini Crater Monday.
Watchstanders at Sector Honolulu Command Center received notification at 3:20 p.


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The Flavor Apprentice is a division of The Perfumers Apprentice. These flavors are concentrated professional grade food flavorings.
We are currently offering the Professional Flavors in your choice of 6ml, 20ml and 30ml!
If you are looking for larger sizes, we now have 4 ounce bottles in limited flavors!
There is no perfect percentage to start with as each flavor is different and each persons taste buds are also different. We do suggest that with the coffee flavors customers start low, 1-2% is often a good place to start with them and then you can build up the flavor to your desired level. With most flavors a good starting point is 10% and then adjust to taste.
Please be aware, flavors are not returnable so try them in a smaller size before ordering a larger one.
* Flavors that we carry that contain Custard notes: are now noted in the drop down menu with an * behind their name.
Click here to see how custard notes can affect flavorings They are not recommended for inhalation but consumption
Looking for a flavor we do not have yet? Email us at email@example.com and let us know!
Showing reviews 1-50 of 301 | Next
Posted by Emerson romine on 19th Nov 2014
The order is always rt and prices are great. Delivery us always within 3 days. Recommend to everyone.
Posted by Unknown on 17th Nov 2014
Really like these flavors and will be buying more
Posted by MIA on 10th Nov 2014
Great flavors!! Good quality!!
Posted by James on 8th Nov 2014
One of the best I love it and at one stop diy shop the ppl there are awesome great deals and super fast thanks guys
Posted by Ionman on 5th Nov 2014
Good quality, good selection, great shipping
Posted by Zac Darnell on 5th Nov 2014
My customers and employees love the ejuice i make with your extracts. By far the best fruit extracts I have ever bought.
Posted by Unknown on 3rd Nov 2014
The best flavors i have found and you dont need a high % to taste it
Posted by RJH on 31st Oct 2014
Great stuff. Really gives my menthol a kick.
Posted by Rob on 26th Oct 2014
After many years of smoking, my taste buds are somewhat whacked. Certain e liquids do not contain enough flavor. i.e. Peach, Blueberry, Passion fruit. I have ordered e liquids with extra flavor, but for me there just isn't enough. Bought these plus Black Cherry to boost the e liquids I have in those flavors. Works like a charm. Very natural tasting. Will be buying more in the future!
Posted by duncan on 24th Oct 2014
The flavor is great, great price and speedy service.
Posted by EMILY CHIODINI on 23rd Oct 2014
Delicious for desserts!
Posted by Dave Fletcher on 22nd Oct 2014
First time diy'er here and with the recipe i used i absolutely loved the finale product.
Posted by CaptDJB on 19th Oct 2014
Just perfect ! Very versatile flavor - added 4% to some Strawberry (ripe) 10% for an easy peasy shake n vape (GREAT in a dripper )!
Added to OS Blueberry and many others in the OS line up - just can't go wrong.
As always great service and lightning fast shipping! One Stop is IT !
Posted by Corey on 18th Oct 2014
I have ordered through OneStopDIY at least 4 times and i honestly couldn't be happier with the fast shipping, customer service, and the accuracy in which they put your order together. The flavor apprentice extracts are awesome. They are good quality extracts that are for the most part, spot on. I have tried a few extracts that were not even close, but the rest are fantastic. 5 stars over all!
Posted by Julia Brown on 15th Oct 2014
Bought a 6ml first, and now have ordered a 20ml b/c I have used the 6ml up already. Wonderful flavor profile for your e-juice. Not dry, not harsh, no overly-tobacco influence on your recipe. The flavor does have a mild tan coloring to it, not completely clear (just FYI).
Thank you OSDIYS!
Posted by randy on 13th Oct 2014
Only took like 2 days to get my order.....nuff said
Posted by Unknown on 10th Oct 2014
Flavor Apprentice has all the great flavors you will ever need
Posted by Al USAF on 9th Oct 2014
Used these flavors to make my first E-juice and result was outstanding. 30% flavoring (14% Strawberry, 8% each for the cream and cheesecake), 3mg nicotine level and the rest in VG. Smooth and not overly sweet vape. Perfect and it's my ADV.
Posted by Cash on 7th Oct 2014
Can't beat it
Posted by Topher on 2nd Oct 2014
Yea that's right!
Let me first say, that I've been DIY E-liquid for almost 5 months (mind you I know it's not a long time to some), I took a leap buying from this sight. I had the thought my usual distributer was diluting the concentrated, normally I would use 2ml flavouring to mix a 15ml bottle of E-juice. Short of the story, I can now use .5-1ml per 15ml bottle.
Thank you OSDIYS!! <lovetovape3
Posted by CaptDJB on 1st Oct 2014
New kid on the block is the French Vanilla Creme
had to grab a 30ml new it would be good and *clean* .
The Strawberry (Ripe)30ml will be new for me, but looking forward to mixing that up with some menthol crystals for a fruity ZING!
HAPPY FIVE YEARS and here's to MANY MORE!!
ONE STOP is my ONE STOP :)
Thanks Kimmer and Shane !
Posted by seth catley on 30th Sep 2014
These flavors have never let me down and neither has one stop diy. One stop is efficient, reliable, and has honest prices that will always make me shop with them.
Posted by Christopher Carmean on 27th Sep 2014
Great product.
Posted by Joe Fox on 26th Sep 2014
I love all the tfa flavors i've tried so far. The guava does turn a bit floral/perfume(y) in straight VG after a bit though. Otherwise would have been 5 stars. Service was 5 stars though shipping (USPS) tracking sucked (NOT ONE STOPS FAULT BTW).
Posted by Cw Hink on 22nd Sep 2014
great flavors, so far i have tried dill pickle,blackberry, banana nut bread,aplle pie,cinnamon,watermelon. all were great.
Posted by Bob on 22nd Sep 2014
You cannot beat the delivery time and price of this item. OSDIYS is a safe, responsible vendor with great products.
Posted by Mike Daniels on 22nd Sep 2014
Great product and great customer service
Posted by Scott on 19th Sep 2014
This is the only place I will shop for my DIY supplies. An example of why: last order I forgot to add one of my flavors so I sent an email asking if I could add a product to my order to avoid another shipping charge. I sent this email at 11:20 pm and Kimberly got back to me within 15 minutes to inform me she placed a credit on my account for the amount of shipping and to go ahead and order the product and it would be shipped out with the rest of my order. That type of service is hard to come by these days. All of the products I have ever bought have been of high quality, fresh and shipped very quickly for a great price, not to mention she upgraded the quantity of some of my flavors as a thank you for ordering. Oh yeah I love the free candy and swag with every order too. IMHO this is the only place to shop for supplies. Keep it up DIY, thanks for the great service, products and prices!
Posted by Lacy Warfel on 16th Sep 2014
I've used these for 3 businesses now, always great quality.
Posted by Unknown on 15th Sep 2014
I just recently started with OSDS, and I couldn't be happier. They have fantastic flavorings at a great price. I've tried many flavorings from different websites, yet most have let me down. :( I highly recommend One Stop DIY show.
Posted by maddie on 12th Sep 2014
Every order I get in the mail from this company is excellently packaged. Never had any leaking bottles or any other damages. Excellent shipping and customer service. Top notch company!!
Posted by Emma on 12th Sep 2014
I only buy my flavors from One Stop DIY Shop. Not only is the quality excellent and the prices very good...but the people there are amazing, the service is awesome, and they even toss in little extras that make the whole transaction extra special. I will be a loyal customer as long as One Stop DIY Shop wants to keep selling their fine products to me!
Posted by Adrianne on 11th Sep 2014
These folks are the best, bar none! Products are fantastic, shipping is lightening fast...everything we ALL love in an online shop. And I especially like the presents they send with each order...keep 'em coming!..I look forward to seeing what's in each box. :)
Posted by D.Stewart on 10th Sep 2014
Great flavor, fresh product packed well & shipped fast.
Highly recommend One Stop DIY to all.
Thanks for all guys, I'll be back.
Posted by Pati on 9th Sep 2014
I've tried different brands and this is one I always come back to. One stop diy shop has great service, price and product. I also recommend the flavors they have made. They are really good.
Posted by Unknown on 3rd Sep 2014
The blueberry was doable, but the caramel was like burnt chocolate. Was happy with prices and the fast shipping. Will certainly come here again to choose different flavors. I love the DIY shop
Posted by Jon B. on 25th Aug 2014
The flavors smell very good, but don't always translate well to taste. With some of the flavors I have to use high percentages to get decent flavor, and some are very strong, a happy medium would be great.
Service and shipping is always excellent.
Posted by Marty on 24th Aug 2014
These flavors are great. You can mix them how you like to. There are no bad flavors in the batch I ordered. I am so pleased with the very fast shipping and great customer service.
Posted by Brett Clark on 22nd Aug 2014
The Flavor Apprentice Professional Flavors are always very good. Price is good. Nice you can get different sizes to choose from.
Posted by Margo on 20th Aug 2014
I am not new to the amazing flavors from The Apprentice , but now I'm making my own e-juice. Ordering is easy and the shipping is super fast! You really feel like a person when you get your package in the mail. Will be ordering all my favors here!
Posted by Dan Trueblood on 19th Aug 2014
Bought several tfa flavors. Mostly fruits. So far I've been happy with all of them. Would be nice to have individual flavor reviews in here. I go look on another site for the reviews and come back here to buy since it's cheaper.
Posted by Franklin on 18th Aug 2014
Could not ask for anything else...the are so easy to work with...and make great juices
Posted by Joel on 18th Aug 2014
Great selection fast shipping. Definitely the place for DIY. Thank you.
Posted by Alan on 14th Aug 2014
I 100% prefer these over the loran for my usage. They are terrific!
Posted by carlo on 8th Aug 2014
These juices are our top sellers at my vape shop. Hands down the best ones on our shelves. Can't wait for the latest creation from the guys!
Posted by laura on 6th Aug 2014
Easy to mix. Tastes great!
Posted by Jefrrey L on 5th Aug 2014
Making your own e-juice can be great, provided you can consistently replicate the flavor your after. These flavors have always made it a snap! Great flavors mean a great finished product. Never have to change my recipes like I did using other base flavors.
Posted by Jim McQuillen on 15th Jul 2014
OSDIYS is like having a mom and pop store down the street! Excellent products, communication and speed of shipments!!
Posted by Philip on 12th Jul 2014
Got my order in three days and no leaks, like the last Co. I ordered from. Love the flavors and the different sizes that you can order. Great packaging and the extras are so nice.
Posted by Steve on 10th Jul 2014
almost seems to need steep time
Showing reviews 1-50 of 301 | Next


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Get ideas and inspiration, find easy to use patterns
and tutorials for your next sewing project.
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Find out more about our three fabulous courses starting this week!
Backstage Report
Choose from one of 5 popular dresses.
Member Project of the Week
Kick off party dress season with this cute greenery covered dress.
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See Meg's picks and get them at a special price with an extra discount for Black Friday
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See how Meg made this edgy dress using the Janome Artistic Edge Digital Cutter!
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Best Trails
Hieroglyphic Trail
Gold Canyon, AZ
More Activities
Hieroglyphic Trail is a 3 mile trail located near Gold Canyon, Arizona. The trail is primarily used for hiking and is accessible from September until May. At the end of the trail are petroglyphs and small waterfalls in early spring.
Best Hiking
Best Mountain Biking
Best Trail Running
Hieroglyphic Trail
Gold Canyon, AZ
Goldmine Trail
Gold Canyon, AZ
Wind Cave Trail
Mesa, AZ
Recent Reviews
Hieroglyphic Trail
Connor England (253)
4 days ago
6 Completed 3 Reviews
Easy hike that keeps a steady low grade incline. Moderate traffic. Fun small pools at the end and hieroglyphics are definitely worth checking out. I would love to see the pools after rain!
Peralta Trail
Donald Webster (177)
10 days ago
5 Completed 3 Reviews
This is trail is magnificent. The desert here is truly alive and thriving. The photos of this canyon do not do it any justice, you simply need to go up and experience it for yourself.
The trail starts out fairly easy and works up the difficult as you climb. The final 1/3 of the trail is the most difficult to cover, but it is worth the effort. For the parents out there, my 5 & 7 year old were able to handle the entire trek under their own power. There was a lot of asking how close we were to the car the last mile down, but they didn't need any help other than the occasional navigation of a few 2-3 foot drops in the trail over some rocks.
Don't quit before you get to the saddleback and have the chance to gaze upon Weaver's Needle though, you will be selling yourself short if you do.
Hieroglyphic Trail
Rod Craig (42)
13 days ago
5 Completed 1 Reviews
Hieroglyphic Trail
Seppe Ramaekers (58)
15 days ago
3 Completed 3 Reviews
Short and beautifull trail. Good for beginners.
Hieroglyphic Trail
Donald Webster (177)
16 days ago
5 Completed 3 Reviews
The hike up can be a little rough as the trail is filled with baseball sized rocks in many places, and plenty of them. My children didn't have too much trouble on the way up, but on the way down they were feeling the effects a bit more.
Lovely views, throughout the trail and the reward at the top is definitely worth the effort. Lot of fun things for kids to explore between a small cave structure created by some enormous boulders, interesting petroglyphs and plenty of space to sit and enjoy a snack.
Highly recommended, just be ready to carry little ones down a bit if you take them all the way up into the canyon near the pools and petroglyphs.
Hieroglyphic Trail
Carol Alexander (61)
30 days ago
3 Completed 3 Reviews
great beginer hike, look for the trail past the water ponds and continue up the canyon for some spectacular water falls after a good rain, kaprox 2 more hours
Peralta Trail
Carol Alexander (61)
30 days ago
3 Completed 3 Reviews
one of my favorite hikes was Peralta Trail to the first water. this was long but so worth it.
Hieroglyphic Trail
January Brady (151)
about 1 month ago
3 Completed 2 Reviews
Very nice trail, not too hard. The surprise at the end is beautiful!
Hieroglyphic Trail
Tamara Potter (83)
about 1 month ago
3 Completed 1 Reviews
Fun trail. Pretty easy and a good one to do with kids.
Bluff Spring Loop
Nicole Padilla (184)
about 1 month ago
10 Completed 3 Reviews
I agree that you should wear long pants, even if it's hot. This was my first time in the area and my legs got ripped up. We went clockwise from the beginning of the Dutchmen trailhead and looped around. It was a little over 9 miles but beautiful views. I look forward to checking out other trails I'm that area.


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Come On, Girls. Give Him A Little Credit.
I can't speak for other guys, but Christmas shopping is a miserable, stressful experience for me. In my view, Christmas gifting is definitely a Labor of love. A new survey by dating service It's Just Lunch says women don't give men enough credit


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November 27, 2014
The sluggish economy is even taking a toll on potbellied pigs.
The Pigasus Pig Sanctuary was forced to cancel its annual Christmas open house because of the economy. The open house usually serves as a fund raiser for the sanctuary which is need of a lot of things according to those that run it. New cages are needed for the vet room and a new building to house the therapy tubs is also needed among other things.
The sanctuary has more than sixty pigs up for adoption. For $450
you can adopt a pig and care for it at your own home, or you can stop by Pigasus each week and spend time with the animal.
To find out more about adopting a pig go to www.pigasus.org.
This year the sanctuary is working on a program to use the pigs as a companion therapy pet for children.
KKCO firmly believes in freedom of speech for all and we are happy to provide this forum for the community to share opinions and facts. We ask that commenters keep it clean, keep it truthful, stay on topic and be responsible. Comments left here do not necessarily represent the viewpoint of KKCO 11News.powered by Disqus
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Battery Disposal & Recycling
2 Day Service (ex VAT)*: £6.95
Total (ex VAT)*: £26.90
Total (inc VAT)*: £32.28
*All orders over £49.95 ex VAT enjoy free 2 day shipping regardless of total weight. Below this carriage is charged at £6.95 ex VAT for 2 day service. The shipping discount is applied during checkout.
A Battery Disposal and Recycling Service from Critical Power Supplies in line with the WEEE Directive on disposing of batteries.
Upto a maximum weight of 20Kg
This service in a box product includes -
- Packaging instructions.
- Arranging collection instructions and confirmation of the number to call.
- Label to be attached to packaging.
Once your battery arrives at our Battery Diposal and Recycling Centre, it will be prepared for recycling thereby helping to limit our impact on the environment.
It is worth noting that:
The EU directive was created to deal with the approximately 800,000 tonnes of automotive batteries, 190,000 tonnes of industrial batteries and 160,000 tonnes of consumer batteries that are placed on the EU market every year. The metals used range from lead and mercury to nickel, cadmium, zinc, lithium and manganese.
Note: This can only be purchased from Critical Power Supplies Ltd when purchasing a replacement battery solution.
Our customers say
"The Eaton Evolution UPS range does exactly what it says, I'm very happy with my purchase".Greg Jones, Welwyn Garden City
|Product Specifications
|Battery Disposal & Recycling
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