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In partnership with the World Intellectual Property Organization (WIPO), BVGH manages WIPO Re:Search and leads partnership development. Collaborations are facilitated between members and across geographies, including pharmaceutical partners, academic institutions and nonprofits.
>> Learn more about how BVGH builds partnerships.
More than 60 WIPO Re:Search collaborations have been facilitated by BVGH resulting in new research and product development for neglected tropical diseases, malaria and tuberculosis.
Access to pharmaceutical compound libraries with drug-like properties is made possible through WIPO Re:Search for repurposing for neglected tropical disease applications.
Learn more about WIPO Re:Search.
Merck, Sharpe and Dohme supports University of California San Francisco's Conor Caffrey investigation of HMG-CoA reductase inhibitors, commonly known as statins (cholesterol lowering agents), as treatment for schistosomiasis, a parasitic disease.
BVGH has the expertise to create, organize and execute training at international academic institutions, biopharmaceutical companies and diagnostic companies for African biomedical researchers.
>> Learn more about how BVGH supports research and development.
Fidelis Cho-Ngwa (left), associate professor at the University of Buea, and Wellington Oyibo (left-center), associate professor at the University of Lagos, participated in three month sabbaticals at Novartis' research site in Basel, Switzerland where they worked with Petra Keil (right-center) and Dominic Ehrismann (right), both of Novartis. Collaboration continues between Novartis scientists and their guests, well beyond the three month sabbaticals.
BVGH develops innovative programs for pharmaceutical company employees to contribute to biomedical research at African universities and research institutions.
Learn more about BVGH's Fellowship Programs.
Katherine Young (left) and Nicole Buist (right) from MSD visit the University of Buea, Cameroon, Noguchi Memorial Institute for Medical Research, Ghana, and Kenya Medical Research Institute, Kenya. During their visits, Nicole and Katherine work alongside their host scientists sharing knowledge and imparting their pharmaceutical expertise through formal seminars.
BVGH recognizes the capabilities, strengths, and assets that developing world institutions can contribute to global health research. By facilitating collaborations between developed and developing world research organizations, BVGH accelerates innovation.
Learn more about how BVGH can Connect You with Developing World Collaborators to advance product development.
Manu Prakash (center-right), a professor at Stanford University, was hosted by Wellington Oyibo (left), an associate professory at the University of Lagos in Nigeria. During his stay, Manu tested his paper microscope (Foldscope) on human patient samples collected from locations around Lagos. Manu also ran a workshop on Foldscope fabrication and attended a training seminar on malaria diagnostics that focused on the issues and challenges faced by Nigerian cell biologists.
BVGH designs, implements, and manages capacity building programs that support the development of biomedical research capacity in African research organizations. Learn more about BVGH's work in capacity building in Nigeria through the BNCBI program.
BVGH, along with the Nigerian National Universities Commission, launched the BNCBI program this year in Abuja, Nigeria.
Impacting global health through multi-stakeholder initiatives, high impact partnering, and alliance management.
BVGH has a unique perspective: we look at the health problems facing developing countries and emerging markets through a dual lens with expertise in both global health and biopharmaceutical industry dynamics.
For more information about BVGH, services offered, or current programs download the brochure
The 2014 Access to Medicine Index was just published, and evaluates the top 20 research-based pharmaceutical companies on their efforts to improve access to medicine in the developing world. The report analyzed 95 indicators in seven key technical areas. Among the report's key findings was that substantial proportion of R&D takes place in access-oriented partnerships. Wim Leereveld, CEO and Founder of the Access to Medicine Index, said, "Transparency was once far away, today we have the clearest ever picture of the Industry's strengths weaknesses, progress and struggles."
Learn more about the 2014 Access to Medicine Index and download the report.
Jennifer Dent, president of BVGH, contributed an OpEd to the Seattle Times in August outlining the need for new approaches to drug development for diseases important in the developing world, such as Ebola. The recent outbreak of Ebola is West Africa has been declared an international public health emergency by the World Health Organization. Read the full article.
Four new collaborations were finalized under WIPO Re:Search in May, including one between Eisai and the Liverpool School of Tropical Medicine (LSTM). Under this agreement, Eisai will provide a set of inhibitors to the LSTM to examine inflammation induced by Plasmodium-infected red blood cell adherence to vascular endothelial cells. To learn about the other new collaborations, read the latest WIPO Re:Search Snapshot.
Katherine Young and Nicole Buist, research scientists at Merck, completed their fellowships with BVGH in August. After two weeks with the BVGH team in Seattle, Katherine and Nicole weree hosted by research institutions in Cameroon, Ghana and Kenya. Learn more about BVGH's Fellowship Programs.
Jennifer Dent, president of BVGH, hosted two panel sessions at the Biotechnology Industry Organization's (BIO) annual International Convention on June 25th in San Diego: The Changing Landscape of Industry's Engagement in Global Health and Africa: The Next Biotech Frontier?.


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4:30 PM Elem BBB Engadine @ Home
6:30 PM Science Fair Parent Meeting
Annual Education Report
Where to find out about school closings and delays
Find important information on student insurance here.
MSSA is a program honoring high school students who give commendable service to benefit Chippewa, Luce, and Mackinac Counties.
A website of resources for students, parents and staff regarding bullying.
You can find user guides and other important helpful information to become a substitute at Pickford Public Schools.

subset: commoncrawl


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Latest news
Quattro boss confirms 'discussions' around yet-faster version of next-gen V10 supercar. Good news!Audi considering hardcore R8 'RS'
Open fire: it's Ferrari's F60 America
Maranello's V12 masterpiece, the 730bhp F12, loses its roof. Time to invest in ear defender stocksOpen fire: it's Ferrari's F60 America
What's the finest engine noise ever?
New video of Merc's V8 AMG GT S is incredible, but what's your favourite ever engine note?What's the finest engine noise ever?
First drive: new VW Passat
Paul Horrell suits up to commute in VW's all-new big family car. Can it out-Mondeo the new Mondeo?First drive: new VW Passat
Is this Alonso's new F1 engine?
This engine video is our first taster of the new McLaren-Honda tie-up. But who'll be driving?Is this Alonso's new F1 engine?
First drive: Audi S3 Cabriolet
The Audi niche-busting machine mashes up hot hatch and convertible. And it's a relative successFirst drive: Audi S3 Cabriolet
First drive: Fiat Panda Cross
Fiat's fitted the Panda with some serious off-road tech. We drive itFirst drive: Fiat Panda Cross
Here's a Ferrari covered in rave paint
How to remind us the California exists post-Speciale A? Swathe one with UV paint, obviouslyHere's a Ferrari covered in rave paint
This is a 1,000bhp Hyundai
'Blood Type Racing' reveals mad Genesis Coupe built for SEMA. It's red, and it's FASTThis is a 1,000bhp Hyundai
Driveclub: the Top Gear review
Another brand new racing game has landed, but is the PlayStation 4's newest racer any good?Driveclub: the Top Gear review


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Lauren's Reviews > The Art of Racing in the Rain
The Art of Racing in the Rain
by Garth Stein (Goodreads Author)
by Garth Stein (Goodreads Author)
Lauren's review
Apr 24, 12
Read in April, 2012
This book took me awhile to read not because I didn't enjoy it but because I was really busy with work. This book made me laugh cry and even hate the grandparents! Didn't think I would ever say that but I recommend this book to anyone with a dog it's a heart warming book!
Sign into Goodreads to see if any of your friends have read The Art of Racing in the Rain.sign in »
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Liberty Ross on Marriage to Rupert Sanders: Difficult, Lonelyby Hilton Hater at . Comments
Somewhat lost amidst the shock and sadness of Kristen Stewart cheating on Robert Pattinson is the other side of this dishonest coin:
Rupert Sanders, with whom Stewart made out on at least one occasion, is a married man with two children.
And in an ironic bit of timing, his wife - 33-year old model Liberty Ross - opened up to YOU Magazine just two weeks ago about her marriage to the director. It's not excuse whatsoever, but there clearly have been problems at home.
"I romanticized domesticity for a while, and loved having a shopping list of groceries stuck to the fridge for the first time," Ross told the publication. "But moving here and starting a life all over again was a lot harder than I had anticipated. I just didn't think it would be as isolating and daunting as it turned out to be."
With Sanders off filming Snow White and the Huntsman, Ross admits she got very lonely.
"I would never say out loud that I am raising my children alone, but a lot of the time it has felt like that."
Ross also lamented how she went from working in the modeling industry with stalwarts such as Karl Lagerfeld and John Galliano… to "living on an isolated hilltop with my husband gone most of the time." However, she ended the interview on a positive note:
"That's why everything feels so amazing now. We rode through the really hard times and we stuck it out."
Yeah. About that...
Sanders issued his own apology yesterday after news of his dalliance with Stewart broke. He said:
"My beautiful wife and heavenly children are all I have in this world. I love them with all my heart. I am praying that we can get through this together."
Kristen had stated how she wanted to keep "their relationship private" because that was only theirs and she didnt wanted everyone IN it!! she just made a fool of herself and broke Robs heart she should had come clean to him rite when it happen if she was trully sorry!!! Tabloids and press are always after any actor or artist and also after their bad moves!!!
Left alone and in pain for eternity? That's a little over the top. Lots of people cheat. It sucks and it isn't nice, but it does not make them awful people. We all know someone who has cheated on someone, and we still love them(as long as we are not the one they cheated on). My point is that we all make mistakes. They may be celebrities, but they are still human. Just saying.
Hes a grown man. He knew exactly what he was doing and what the risks were. As for Kristin saying that she respects Rob more than anything in the world ,REALLY, if thats what she considers respectful I would hate to see what disrespectful means to her!
apology for us? I mean the words sound like they are written by someone else. phony crap for the entertainment blogs. if they aren't the guy really is a jerk a phony andneed i say more
Get through this together? Haha nice words after cheating on her. This guy deserves to be left alone and in pain for all eternity. hoovaaaa


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New Poll Shows Americans Strongly Oppose 20-Week Abortion Bans
In Congress and across the country, opponents of women's health have continued their crusade to try and chip away a woman's right to a safe and legal abortion. Most recently, they've been attempting to do this by pushing for a ban on abortion after 20 weeks.
The reality is that nearly 99 percent of abortions occur before 21 weeks, but when they do happen, it's often in heartbreaking and unusual circumstances. It's no wonder that when voters understand the real-world circumstances, they overwhelmingly oppose laws that would ban the procedure at that stage.
In fact, a new poll shows that when Americans learn about the variety of circumstances in which abortion would be made illegal under most 20-week ban proposals (like the ones approved by the House of Representatives), they overwhelmingly opposed them. Understanding that abortions are very rare at this stage in pregnancy and that fetal abnormalities are often involved in the instances, a solid 60 percent of registered voters support access to abortion at 20 weeks, with only 33 percent opposing access.
It's no wonder that a majority of voters — Republicans (62 percent), Democrats (78 percent), and Independents (71 percent) — believe this is the wrong issue for Congress and their state legislators to be spending time on. In fact, according to Geoff Garin, president of Hart Research Associates, "The margins in opposition to these bans are so significant that we think it is very likely that they would be voted down in a popular referendum in virtually any state of the country, after people have had a chance to learn about the real-world consequences of them."
And yet, in spite of public opinion, politicians continue to push these extreme measures, without considering the women that have to live with the consequences. In states that have passed laws that ban abortion after 20 weeks, some women and their families have been put into unimaginable situations — needing to end a pregnancy for serious medical reasons, but unable to because of extreme laws that don't reflect the real-world situations women, their families, and their doctors face. Women and their doctors need to have every medical option available to them; they don't need politicians interfering with their personal and private medical decisions.
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text: CCBot/2.0 (http://commoncrawl.org/faq/) British Columbia Geocaching Association » Forums » Regional » Lower Mainland / Coast Mountains » Dinosaur Hunt in Stanley Park Home Newest Caches Forums Your Account About BCGA Search Blitz Agassiz Tulips: [?] . Every spring the tulip fields of Agassiz and Bradner explode with colour. [M | C] Register or Login Please Join our Association Our Sponsors Waypoints Home Home Login BCGA News BCGA Feedback/Contact Us Membership Info Coin Activation About BCGA Logos Recommend Us Statistics News Archive VT Memorial Project Geocaching Cache History Encyclopedia Links Policies & Guidelines Users options Your Account Forums Forums GC Canada Forums Search GC Cache BCGA Search Web BC Rankings Geocaching.com Navicache.com Terracaching.com waymarking.com Coming Events November 2014 SMTWTFS 01 02 03 04 05 06 07 08 09 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 Sat Nov 22, 2014 Hag 2015 - The pre hag event - Courtenay Sat Dec 06, 2014 Fall dinner meet and greet - Sushi night - Surrey Sun Dec 07, 2014 The Cache-keteers Ugly Cachemas Sweater Event-Cobble Hill Sat Dec 13, 2014 12-13-14 - Kamloops 12-13-14 Under the Christmas Tree - Surrey Sun Dec 14, 2014 3rd Annual Christmas Micro Container Exchange-Kamloops Forums » Regional » Lower Mainland / Coast Mountains » Dinosaur Hunt in Stanley Park Forum FAQ Search Log in to check your private messages Login Dinosaur Hunt in Stanley Park Forum Index » Lower Mainland / Coast Mountains View previous topic :: View next topic Author Message hollyburnJoined: Jul 22, 2006Posts: 162Location: Vancouver Posted: Tue Jul 20, 2010 6:25 pm Post subject: Dinosaur Hunt in Stanley Park This looks like fun.....July 21 - Aug 1 2010 ....Go on a dinosaur hunt in Stanley Park to win tickets to the Neanderthal Arts Festival www.thal.ca/news/geoca...-dinosaurs Back to top Display posts from previous: All Posts1 Day7 Days2 Weeks1 Month3 Months6 Months1 Year Oldest FirstNewest First Forum Index » Lower Mainland / Coast Mountains Page 1 of 1 All times are GMT - 8 Hours Jump to: Select a forumTerms of Usage AgreementGeneral AnnouncementsPoliciesCALL BINGO WINBingo DiscussionGeneralRecommend a CacheHow To?SWAGMilestonesNews Article DiscussionsFraser ValleyKootenay - RockiesLower Mainland / Coast MountainsNorthern B.C.Thompson / OkanaganVancouver IslandWebsite Questions2012 Director Nominations & Discussions You cannot post new topics in this forumYou cannot reply to topics in this forumYou cannot edit your posts in this forumYou cannot delete your posts in this forumYou cannot vote in polls in this forumYou cannot attach files in this forumYou cannot download files in this forum Advertisement :: Copyright 2003 - 2009 BC Geocaching Association :: RSS Feed:Follow us on Twitter: http://twitter.com/BCGeocaching Interactive software released under GNU GPL, Code Credits, Privacy PolicyTheme by British Columbia Geocaching Association.


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Day 1
Byon October 8, 2013
For the next two weeks, Esquire correspondent and model Melissa Stetten is testing the definition of sexyand sharing the results with us.
Dear Esquire,
Yesterday, I posted a photo on Instagram and Twitter of what I perceive to be the least sexiest characteristics of women according to men cats, self-help books, sweatpants, zit cream, watching Eat, Pray, Love on my laptop, and I'm actually wearing my retainer but you can't see it (I seriously still have to wear that thing or my teeth will go back to looking like Amy Winehouse's). It got 191 likes, which is definitely above average for me. Not one person said it wasn't sexy. Some dudes even commented "ABSOLUTELY SEXY" and "DEFINITELY SEXY." Never mind that those guys are playing World of Warcraft in their moms' basements and would fuck Steve Buscemi in a wig. My conclusion guys don't care how many mental illnesses you have, if you're doing a sexy pose on a bed they'll still be attracted to you.
Follow all of Esquire's Great Sexiness Experiment here.
Follow Esquire Magazine on RSS and on Twitter at @Esquiremag.
What To Read Next
0183 Things Every Man Should Do Before He Dies
02A Few Billion Dollars, Over 400 NBA Players, And The One Woman Who Can Bring Them Together
0325 Skills Every Man Should Know
04How Your Office Became A Middle School Chat Room
05Christina Hendricks Has 10 Pieces of Advice for Men
06There's A New Technology That Encourages You To Scream At Your TV To Skip Commercials
07The State of The American Dog
08The 50 Best Manly Movie Quotes
0910 Things Men Need to Stop Wearing to the Gym Immediately


text: News Category: All AHT Cares Awards Employee Benefits Events Financial Institutions General News Global Risks Law Firms Nonprofits Press Releases Technology View Archives Results: 178 Article(s) Found. 1 2345 next > Nov 14, 2014 India Insurance News - October 2014 October 2014 India insurance news update from AHT partner Prudent Insurance Brokers. Download Document Oct 17, 2014 India Insurance News - September 2014 September 2014 India insurance news update from AHT partner Prudent Insurance Brokers. Download Document Oct 16, 2014 Strategic Health Plan Changes to Consider Under the Affordable Care Act Event - November 5, 2014 You've had to make all sorts of adjustments and changes to your health benefit plan to assure compliance with the Affordable Care Act, but is the result really what your company wants? Is it meeting the current and future needs of your company and employees? Join us November 5, 2014 as we discuss options available to you to get your health benefit plan operating in a manner which meets the short and long-term goals of the company and employees. Read More Oct 14, 2014 TechAssure 2014 Q4 Newsletter Topics include social media and millennials. Download Document Oct 09, 2014 Independent Schools Business Managers' Roundtable - November 5, 2014 Join us for the Independent Schools Business Managers' Roundtable discussing the Upcoming Financial Statement Overhaul on November 5, 2014. Read More Oct 08, 2014 AHT Fall 2014 HR Newsletter AHT's Fall 2014 newsletter features an update on Health Care Reform, an update on Medicare, and Diabetes Disease Management. Download Document Hackers and Data Breaches: Corporate Avoidance & Survival Every day we wake up and read about a new data breach. Small businesses get hacked too –they just generally don't make the news. Is your IT staff taking the right steps to protect sensitive client and employee information against hacking, carelessness and theft? And does your insurance cover you when those measures are not enough? Cybercrime is increasing as is the amount of sensitive electronic information that we all store. Join us 10/7 to learn what you can do to protect your company. Read More Sep 24, 2014 AHT's David Schaefer featured in Business Insurance Broker Beat Video Series Business Insurance Associate Editor Bill Kenealy speaks with David Schaefer, Principal and Executive Vice President of AHT Insurance about cyber risks and other issues currently affecting the insurance brokerage. Read More Sep 18, 2014 India Insurance News - August 2014 August 2014 India insurance news update from AHT partner Prudent Insurance Brokers. Download Document Sep 12, 2014 AHT Insurance Honored With 'Best Practices Agency' Designation AHT Insurance has been named a 'Best Practices Agency' by the Independent Insurance Agents & Brokers of America (IIABA) in a study of the leading independent agencies. Read More Results: 178 Article(s) Found. 1 2345 next > View All (178)


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The Who Announce North American Tour
THE WHO, one of rock's legendary and defining bands, have announced a major North American arena tour where they'll perform their iconic 1973 double album QUADROPHENIA in its entirety, along with a selection of WHO classics. The critically acclaimed QUADROPHENIA marked the British band's second rock opera (after Tommy), raised the bar for rock albums as an art form and hit #2 on the U.S. Billboard album chart. Founding members Roger Daltrey and Pete Townshend will be joined by Zak Starkey (drums), Pino Palladino (bass), Simon Townshend (guitar/backing vocals), Chris Stainton (keyboards), Loren Gold (keyboards/backing vocals) and Frank Simes (musical director, keyboards/backing vocals). **See a Q&A with Pete Townshend near the end of the release.
In addition, subscribed members of The Who's official fan club will be given priority access to purchase tickets for the upcoming "Quadrophenia" tour. The offer begins at 10:00 AM on July 20 and expires July 22 at 10:00 PM. All current members of the official The Who Fan Club, as well as any new members who join, will be given an exclusive member's only code that will activate the offer. Membership is available at fanclub.TheWho.com.
The upcoming WHO tour will offer a number of exclusive VIP experiences and packages. These offers may include a number of exciting perks: great seats, a special invitation to The Who's VIP preshow sound check, limited edition autographed memorabilia, preshow parties (including complimentary food & beverage), VIP preferred parking, exclusive VIP merchandise and more.
The American Express presale for the U.S. dates runs July 23-26 and July 23-25 in Canada before the general public on sales beginning on Friday, July 27 at 10:00 AM.
The AEG-promoted 36-date tour, the band's first North American tour in four years, kicks off November 1 in Sunrise, FL with an initial six-week run. THE WHO will return in late January with more dates commencing January 28 in Anaheim, CA. Tickets for the tour will be available at www.aeglive.com
About Author
- Anna Kendrick and Jeremy Jordan-Led THE LAST FIVE YEARS Movie to Hit Theaters, VOD on Feb 13
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- 'BREAKING BAD (Original Score From The Television Series) Volume 2' Double LP Out Today
- President Obama Praises Icons Meryl Streep, Alvin Ailey and More at Medal of Freedom Ceremony
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"So if you want to make sure, you can be sure that I understand what these proceeding [sic] can end up with: the end of my life."
Related quotes
"Word is already that we are only sending blacks out of this state. We are make (sic) a strategic error. FEMA will not have to answer to the people, we will."
"diagrammed the affiliations of al Qaeda and showed Mohammed [sic] Atta and the infamous Brooklyn Cell."
"Out of the rubbles [sic] of Trent Lott's house --he's lost his entire house. There's going to be a fantastic house. And I'm looking forward to sitting on the porch."
"I want to make it clear that Stacker has not been terminated (sic). The fact is that the board has merely elected not to offer him a new contract."
"If you fumble the ball on the 15-yard line (sic), the other team's going to score. It's just that simple."


text:
|Boxing Champions | Boxing Schedule | Boxing Video | Boxing History | Pound For Pound | The Wire | Audio | Arcade
|Home Tags index Freddie Roach
|Roach Pleased With Pacquiao's Conditioning in Camp
�Trainer of the Year� Freddie Roach buckled down to work with �Fighter of the Decade� Manny Pacquiao at his training camp in General Santos City on Monday and was pleased about the condition of hi...
reviews | forums
|Roach: Pacquiao and Cotto Will Not Spar in Camp
�Trainer of the Year� Freddie Roach, who was scheduled to leave on Monday to join �Fighter of the Decade� Manny Pacquiao at his training camp in General Santos City disclosed that even if Miguel Co...
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|Video: Freddie Roach Discusses Zou Shiming's Next Fight
Hall of Fame trainer Freddie Roach discusses the upcoming return of two-time Olympic gold medal winner Zou Shiming, who fights on Saturday night at the Coatai Arena at the Venetian in Macau, China....
reviews | forums
|Video: Zou Shiming/Roach Open Workout and Interview
Two-time Olympic gold medal winner Zou Shiming is ready for the fourth professional fight of his career on Saturday night at the Cotai Arena at the Venetian Resort in Macau, China. He will face exp...
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|Photos: Zou Shiming Putting in Work With Freddie Roach
Macau, China --- "RING OF GOLD" --- Zou Shiming (R), two-time Olympic gold medalist works out with Hall of Fame trainer Freddie Roach (L) in Macau, China on Tuesday for his upcoming main event on ...
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|Photos: Denis Lebedev Working Hard With Freddie Roach
WBA cruiserweight champion Denis Lebedev (25-2, 19KOs) continues to rebuild his career in California. The Russian puncher came to Los Angeles to learn new techniques, as he prepares for a rematch i...
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|Garcia Shakes Head at Roach's 'Trainer of The Year' Nod
Trainer Robert Garcia is shocked with Freddie Roach being voted in as the '2013 Trainer of the Year' by the Boxing Writers Association of America. Garcia believes that his own achievements in 2013 ...
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|Roach Will Be Training Pacquiao To Knock Bradley Out
Hall of Fame coach Freddie Roach will be training Manny Pacquiao with a direct focus on scoring a knockout victory over WBO welterweight champion Timothy Bradley on April 12th at the MGM Grand in L...
reviews | forums
|Roach: Bradley Not Better Than In First Pacquiao Fight
NEW YORK � Joel Diaz considers Timothy Bradley a better, more mature fighter than he was entering his first fight against Manny Pacquiao. Freddie Roach disagrees with Bradley�s trainer. Manny Pa...
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|Cotto, Roach To Start Camp For Martinez on April 14th
According to former three division world champion Miguel Cotto (38-4, 31KOs), an agreement to face WBC middleweight champion Sergio Martinez (51-2-2, 28KOs) is "95%" complete for June 7th at New Yo...
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|Roach: Khan Can't Beat Mayweather, PPV Will Lose Money
NEW YORK � Freddie Roach knows as much about Amir Khan�s boxing ability as anyone. The outspoken trainer doesn�t think Khan can upset Floyd Mayweather Jr., either. But if Khan does indeed land a...
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|Roach: Once Bradley Gets Hit, He'll Revert To Old Self
Manny Pacquiao is no stranger to rematches but none may be as important as the one he will be partaking in April 12th where he faces Timothy Bradley at the MGM Grand in Las Vegas, NV. Despite the m...
reviews | forums
|Pacquiao, Roach Discuss Provodnikov Fight Possibility
After making a successful comeback against Brandon Rios last November, Manny Pacquiao and his team needed to find his next opponent for his first big fight of the calendar year. While Pacquiao and ...
reviews | forums
|Roach Pushing Pacquiao For First KO In Four Years
NEW YORK � Freddie Roach is more than willing to become boxing�s Bible-thumping trainer, if it�ll inspire Manny Pacquiao to seek knockouts the way the powerful southpaw once did. Roach and Pacqu...
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|Roach: Khan Has The Right Style To Beat Mayweather
Trainer Freddie Roach insists Amir Khan can become the first man to defeat Floyd Mayweather. Khan appears to have landed the biggest fight of his career, with reports suggesting he will face May...
reviews | forums
|Roach on 6th BWAA Trainer Award: �It�s Good to Be Back�
For the sixth time in his career, Hall of Fame trainer Freddie Roach has received the Eddie Futch Trainer of the Year award from the Boxing Writers Association of America. Roach also won the awa...
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|Photo: Lebedev Training With Freddie Roach at Wild Card
The world cruiserweight champion of the WBA, 34-year old Russian boxer Denis Lebedev, is getting in some training work with Hall of Fame coach Freddie Roach at his Wild Card Gym in Hollywood, accor...
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|Roach: Marquez Was The Best Option For Pacquiao
Trainer Freddie Roach is disappointed that Juan Manuel Marquez has no interest in a fifth fight with Manny Pacquiao, who is scheduled to return on April 12th at the MGM Grand in Las Vegas. Pacq...
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|Roach Says Pacquiao-Bradley II Could Be Real Stinker
If trainer Freddie Roach had a choice, he would have Manny Pacquiao face Ruslan Provodnikov on April 12th at the MGM Grand in Las Vegas. Provodnikov, along with WBO welterweight champion Timothy Br...
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|Chavez Stays Away From Oxnard After Roach/Ariza Beef
For the time being, former middleweight champion Julio Cesar Chavez Jr. (47-1-1, 32KOs) is going to stay away from training with Robert Garcia at his Oxnard gym in California. Instead, Chavez w...
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Maher to succeed Good as head of Northwood School
September 16, 2014 LAKE PLACID — Northwood School has hired its next head of school, although his first day on the job won't be until next summe. more »»
Downtown Advisory Board recognizes Harris
September 15, 2014 more »»
Saranac Lake students among recipients of Tops scholarships
September 15, 2014 WILLIAMSVILLE — Tops Friendly Market recently announced that it has awarded $833,000 dollars to 733 Tops first-year and matriculated college associates, associate dependents and associate... more »»
Hotel zoning district revised
September 13, 2014 SARANAC LAKE — The village Board of Trustees has made a key revision to the proposed zoning district for a controversial 93-room hotel on the Lake Flower shoreline. more »»
ROOST releases new website
September 12, 2014 LAKE PLACID — Adirondacksusa.com is a virtual tour of the Adirondacks mixed with a high-quality version of Google Maps Street View. more »»
Setting Pole Dam's fate undecided
September 12, 2014 TUPPER LAKE — The town board isn't any closer to making a decision on the 7-acre Setting Pole Dam propert. more »»
Planning Board backs hotel zoning change
September 11, 2014 SARANAC LAKE — The proposed Lake Flower Spa and Resort is one step closer to reality. more »»
Zoning blocks River Street hotel
September 9, 2014 SARANAC LAKE — Local restaurateur Paolo Magro can't build a new hotel on River Street unless the village changes the zoning for the site. more »»
Village to ban 1st-floor apartments downtown
September 9, 2014 SARANAC LAKE — The village wants to ban first-floor apartments in downtown buildings. more »»
Village approves downtown truck ban, tax exemption
September 9, 2014 SARANAC LAKE — In separate votes Monday night, the village Board of Trustees unanimously agreed to ban large trucks from downtown and grant a tax exemption to homeowners who improve their houses. more »»
Natural gas line raises questions
September 9, 2014 MALONE — An update on a natural gas line installation sparked some questions from two legislators who represent the southern end of Franklin County, where the gas is unlikely to reach. S. more »»
Board hears hotel parking garage concerns
September 8, 2014 SARANAC LAKE — Residents of Academy Street said they support Roedel Companies' plan to restore the Hotel Saranac but are concerned about an increase in traffic on their street from a proposed... more »»
Stehl pleads guilty
September 6, 2014 A former Saranac Laker pleaded guilty to federal fraud charges Tuesday in federal court in Los Angeles. William A. Stehl, 69, was raised in Saranac Lake and lived here again in the early 2000s. more »»
Wilmington gas pump decision may be Monday
September 6, 2014 WILMINGTON — Members of the Wilmington Planning Board will review the Little Super Market owners' proposal to install gas pumps during their meeting at 7 p.m. more »»
Police warn of new phone scam
September 6, 2014 RAY BROOK — A new phone scam targets individuals and businesses by threatening to shut off their electricity if they don't immediately settle fake overdue bills. more »»
NY health insurance rates to rise, but less than industry wanted
September 6, 2014 ALBANY — New York insurance regulators have approved higher health insurance rates for 2015, though the increases are smaller than what the industry wanted. more »»
Tupper village OKs electric rate hike
September 5, 2014 TUPPER LAKE — Residents here might see an electric rate increase early next year. more »»
State police warn of new phone scam
September 5, 2014 RAY BROOK — A new phone scam targets individuals and businesses by threatening to shut off their electricity if they don't immediately settle fake overdue bills. more »»
Legislators oppose proposed EPA water rules
September 5, 2014 MALONE — Franklin County legislators passed a resolution to oppose a proposed change to the way waterways are defined under the Clean Water Act. more »»
Museum adds 50 acres along Raquette River
September 3, 2014 TUPPER LAKE — The Wild Center has bought 50 acres of property on the Raquette River, thanks to a group of donors. more »»
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Town Again Watch Howells
Friday, 13th Jan 2012 08:41
Town were amongst a number of clubs at Kenilworth Road to watch Luton's Jake Howells in action as the Hatters beat Stockport 1-0 on Tuesday. The 20-year-old left-back or left midfielder is a player the Blues have been monitoring since last season with Charlton and Peterborough also understood to be interested.
After a spell as a youngster at Watford, Hemel Hempstead-born Howells progressed through the ranks at Luton and is contracted to the Hatters until the summer of 2012.
The 20-year-old has made 113 starts and 39 sub appearances, scoring 14 goals, since making his Hatters first team bow in May 2008.
In addition to three Wales U21 caps, Howells has also made four England C (non-league national side) appearances, scoring one goal.
Meanwhile, Blues boss Paul Jewell may be interested to see that his former Wigan winger David Cotterill has been released by Swansea.
Wales international Cotterill, 24, began his career at Bristol City, Jewell taking him to the Latics for £2 million in August 2006. He joined the Swans from Sheffield United for £600,000 in January 2010.
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Watch Heart's very own Mark Wright and Myleene Klass do the 'Harlem Shake' in a hilarious promo for VBox Gym.
The Harlem Shake is the craze that has swept the internet this year, as thousands of videos have been uploaded of people dancing to Baauer's titular song.
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The Linux 2.6.36-rc2 Kernel Is Out With An Announcement
Published on 22 August 2010 09:57 PM EDT
Written by
Michael Larabel
Linux Kernel
6 Comments
The Linux 2.6.36-rc2 kernel has been released this Sunday afternoon and this time around there's an announcement of the release by Linus Torvalds (he lacked announcing 2.6.36-rc1; Phoronix was one of the few places
reporting on it
). The 2.6.36-rc2 kernel release brings mostly bug/regression fixes, but compared to the
Linux 2.6.35 kernel
, Linus has accepted some pull requests after the -rc1 release in the
Linux 2.6.36 kernel
while denying other requests.
Pulled into the Linux 2.6.36-rc2 release are some of the VFS patches by Nick Piggin, but unfortunately not all of the VFS scalability patches
previously talked about
that are to provide some nice core performance gains. Most of those VFS patches sadly are now queued up for the
Linux 2.6.37 kernel
The second major change in the 2.6.36-rc2 release is another Intel DRM pull (there was already some
fun Linux graphics improvements
committed to 2.6.36-rc1 and a second pull request that added
NVIDIA Fermi KMS support
). This Intel KMS/DRM driver pull has quite a number of driver fixes by Chris Wilson. The changes aren't too exciting, but should be good news for anyone that has been suffering from Intel kernel driver problems. There is added fair LRU eviction, ring-buffer fixes,
Intel Sandybridge
changes, Ironlake-specific fixes, more Embedded DisplayPort (eDP) work, and other changes scattered throughout.
Some of the other Linux 2.6.36 changes talked about by Linus Torvalds in today's release announcement is fanotify -- the latest kernel notification rewrite, workqueue work, and VM layer updates. The fanotify system was started out by Red Hat to cater to the needs of some anti-malware vendors as a better way to handle file scanning with this new notification system and an access system to block processes until a fanotify user-space listener has cleared the operation. However, fanotify is not a security system for Linux but rather an interface to allow such to be implemented.
The release announcement for the Linux 2.6.36-rc2 kernel can be found at
. We continue to benchmark the very latest Linux kernel on a daily basis at
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text: Patophysiology of blood and lymph circulation in lower extremities Assoc. prof. Jana Plevkova MD, PhD 2012 Department of Pathophysiology Jessenius Faculty of Medicine in Martin Blood circulation is sophisticated system which conduct the blood from the heart and lungs into the tissues - it's main function is to provide suitable metabolic supply to the cells /oxygen, substrates/, aw well as the cleavage of metabolic products from the tissue vessels – resistance, capacity, capillary network, other specific vascular structures high pressure / low pressure part of circulation regional specific circulations Arterial system of lower extremities source :http://education.yahoo.com/reference/gray/subjects/subject/157 Principles of blood flow science discipline analyzing the flow of the blood within the circulation P. .r4 Q 8..l Q – blood flow P – pressure gradient between two different points of the tube /vessel/ r – vessel diameter l – vessel length - blood viscosity Arterial system of lower extremities -a part of high pressure circulation Energy of the heart ejection /systolic effort/ continues into 1) frontal pressure, responsible for the forward movement of the blood within the vessel 2) lateral pressure affecting the wall of the artery causing it's distension, giving the base for the pulse wave laminar flow (flow within individual layers smoothly gliding one on another ) - This mutual gliding is responsible for the tangential tension among the layers and most external layer and endothelium, as well (shear stress) shear stress – this mechanism is able to influence some of the regulatory and secretory functions of the endothelium Turbulent flow within the blood stream could be physiological only at the sites of wide vessels - aortal arc, pulmonary artery, site of the vessel branching, sudden bending of the vessel Predisposition for turbulent blood flow - wide vessel - sudden change of the diameter - high blood flow velocity - low blood viscosity - uneven endothelial surface The blood flow in the arteries has three phases, due to elastic properties of the vessel wall 1st phase – forward movement of the blood caused by ventricular contraction – systolic ejection. Vessel wall is distended during this phase, because of lateral pressure applied onto the vessel wall 2nd phase is characterized by return of the distended vessel diameter into the former size – elastic recoil the flow is directed to the beds with low resistance 3rd phase of the diastolic period – the flow is directed forward again Regulation of the blood flow in lower extremities Relative constant pressure gradient – diving pressure is constant, so regulation is secured predominantly by the change of vessel resistance – change of vessel diameter 1. myogenic (Bayliss regulation) 2. metabolic (autoregulation) lactic acid, CO2, H+, K+, adenosin 3. other humoral factors (catecholamine, histamine, acetylcholine, angiotensin) 4. nerve regulation - sympathetic fibers Endothelium – is not only a mechanical barrier It has high metabolic activity, participates in vessel reactivity, regulation of thrombogenesis, influences the functions of circulating cells Endothelial surface – 500 - 1000 m2 – contact surface for the mediation of "signals" between circulating cells and intimal surface It seems to be the largest endocrine organ /1500g/ Metabolic and secretoric systems influence mainly vessel tone therefore resistance and blood flow Physiological tendency to vasodilatation Endothelial vasodilators production of NO – from L arginine by NO synthasis – enzymatic process, new molecule of NO is released into the smooth muscle cells layer beneath the endothelium – activation of guanylatcyclase - production of cGMP leads to relaxation of muscle cells and thus to vasodilatation production of NO is responsible for permanent "natural" tendency to vasodilatation in arterial system production of NO is stimulated by – shear stress, platelets derived molecules like (ATP, ADP, serotonin), vessel distention – flow dependent dilatation NO is dominant vasodilator in basal conditions endothelium produce also other vasoactive substances like - PGI2 (prostacyclin) PGE2, PGD2 Endothelial vasoconstrictors endothelins, tromboxan A2, nonstable endoperoxides, and molecules of local RAA system Endothelins (1, 2, 3) – group of peptides containing 21 AA, derived from molecule of proendothelin, which is fragmented to active molecules ETA a ETB receptors – vasoconstricting response, long lasting effects involve proliferative effects on smooth muscle cells within the vessel wall Endothelial dysfunction Functional changes of the endothelial cells predominance for production of vasoconstricting mediators increased production of cytokines increased permeability for plasmatic proteins and lipoproteins predominance of procoagulating processes increased production of CAM molecules Pathogenesis of diseases of arterial system of lower extremities Diseases with different ethiology may have the same, or very similar signs and symptoms - So it is not correct to talk about "arterial occlusion" only Ischemia of lower extremities - acute – sudden onset of ischemic attac /dangerous, bc of the risk of the lost of the extremity/ - chronic – long lasting ischemization, trophic changes... - Degenerative processes - atherosclerosis /ATS/ - Aneurysmal arterial disease - Inflammation and thrombosis - Vasospastic disease Atherosclerosis obliterans Risk factors fatty and cholesterol containing diet less fruits/vegetable/fiber diet hypercholesterolaemia smoking hypertension low concetration of HDL + family history for CVS diseases obesity increased fibrinogene level male sex (Atherosclerosis obliterans - ASO) patogenesis of ATS – response of the vessel wall to injury 1. functional changes of endothelial cells 2. deposition of lipid particles into the vessel wall with subsequent reaction – creation of fibromuscular plaque 3. chemotactic activity of monocytes – fagocythosis of lipid particles of macrophages (foam cells) lipid plaque Formation of ATS plaques of different size and position in the arterial system of lower extremities Consequences turbulent flow at the site of the plaque location presence of the plaque may lead to "serious" stenosis limiting the blood flow damage of the vessel wall due to plaque may lead to weakening of media and formation of aneurysma bleeding into the plaque with possibility for formation of false aneurysma dysrupture of the plaque with subsequent thrombosis of the artery abruption of the plaque and embolization of those fragments into more peripheral circulation acute or chronic ischemization of extremity Arterial aneurysms http://www.daviddarling.info/encyclopedia/A/aneurysm.html http://images.rheumatology.org/viewphoto.php?imageId=2861575&albumId =75674 Arterial aneurysms – localized dilatation of the vessel wall 1) True aneurysms – consist of all three layers of arterial wall, usually has fusiform or circumferential shape, the underlying condition for such a dilatation is weakening of the vessel wall due to some pathological process – mainly ATS The damage of the vessel wall with weakening of media could be acquired (atherosclerosis, inflammation, toxic ifl.) or inherited (syndroms with weak connective tissue like sy. Marfan) 2) False aneurysms – extra vascular accumulation of blood with disruption, two or all three vascular layers the wall of the aneurysms is formed by thrombus and adjacent tissues, or adventitia False aneurysms is usually consequence of trauma, or complication of ATS plaque http://medical-dictionary.thefreedictionary.com/false+aneurysm Whatever the cause, the aneurysm becomes progressively larger ! tension within the vessel wall is directly influenced by the diameter and the lateral blood pressure localized dilatation of the vessel at the site of aneurysms leads to increase of diameter and therefore enhance the tension within the vessel wall, what again may enhance it´s enlargement Consequences Ischemia below the location of aneurysma Acute thrombosis at the site of aneurysma Dysrupture of aneurysma Embolization of the thrombus into the more peripheral circulation Inflamatory diseases – Thrombangitis obliterans Burger´s disease Inflammatory disease of small peripheral arteries chronic inflammatory process inflammation is localized at the intima of affected vessels, and thrombosis is just a secondary consequence of it affected vessels are prone to vasospasm affected are mainly tibial and plantar arteries Etiopathogenesis of the disease is unknown affected population - men 20 – 40 yrs, smokers, autoimmunity Disease has three stages 1) inflammatory and spastic phase (phlebitis saltans, migrans) 2) obliterative phase with symptoms and signs of ischemia 3) gangrene Vasospastic diseases Attacks of sudden constrictions of small diameter arteries and arterioles of upper and also lower extremities, commonly fingers, sometimes toes Raynaud disease – primary vasospastic without any obvious or clear cause, most affected are young ladies Raynaud phenomenon – syndrome, secondary problem usually linked with systemic collagen diseases, autoimmune diseases, toxic influences, long lasting vibration exposition, ... Raynaud disease In spite the cause is unknown, there was identified hypetrophy of myoepithelial cells, which participate in regulation of blood supply to the capillary bed and hyperplastic changes of a-v- anastomoses cold or emotional stimulus is usually the provoking factor, leading to severe vasoconstriction, blood is redirected through a-v anastomoses into the venous system, while the capillaries are compromised Typical three phasic color changes of the skin, changes are always symetric a) sudden pallor (dogiti mortui) b) followed by cyanosis c) finally redness caused by reactive hyperaemia Raynaud phenomenon It is only a sign (manifestation/ of other primarily well defined disease Example: systemic lupus erythematodes, primary pulmonary hypertension, some endocrine disorders – myxedema-, exposition to vibrations, intoxication with ergot (claviceps purpurea) Symptoms are asymetric, affected persons are both men and women All mentioned diseases may lead to acute or chronic progressive obliteration of the vessel lumen. Obliteration of the lumen increases the vessel resistance. Increased resistance means - decreased blood supply to the affected region with a possibility of ischemia. http://lifeinthefastlane.com/2011/01/cardiovascular-curveball-012/ http://www.bellevuepodiatrist.com/raynauds-phenomenon-red-white-and- blue-toes/ Occlusive arterial disease Chronic occlusive arterial disease ischemia as a result of arterial obstruction Obstructive arterial lesions occur more frequently in the lower extremities than in the upper extremities.Obstruction influencing the blood flow to lower extremities is usually localised. at: - aortoiliac level - femoropopliteal level - popliteo-tibial level Development - arterial lumen is progressively narrowed resistance to blood flowblood flow to the tissue below the lesion is reduced tendency to tissue ischemia - vessel lumen must be reduced by approximately 50% in diameter or 75% in crossectional area to produce clinically significant interference with blood flow - in combination (stenosis occurring in sequence), less significant lesions can seriously impair blood flow Stenosis less than 75% of crossectional area is not compromising blood flow during the rest condition, but during the physical exercise – it could interfere with the blood supply leading to ischemia At the site of stenosis and below the stenosis we can see changes of the blood flow like - acceleration of the blood flow at the site of stenosis - turbulent blood flow below the stenosis with recirculation of the blood, whirls (murmors present above the affected vessel - poststenotic dilatation with possibility for thrombogenesis Example for stenosis occurring in sequence, less significant lesions can seriously impair blood flow When small nonsignificant stenosis may lead to ischemia? During physical exercise (O2 requirements, vasodilatation in working muscle, decrease of driving pressure) During elevation of the extremity (no hydrostatic effect supporting the blood supply) Intensity of ischemic damage depends on – the site /level/ of the vessel occlusion – aortoilic, femoropopliteal, popliteotibial level extent and seriousness of stenosis time course of occlusion development /acute vs. chronic/ presence and quality of collateral circulation Collateral circulation is unique and important compensatory mechanism of long lasting, progressively worsening ischemia. Increased resistance of affected arteries is responsible for "opening" of collateral circulation. Mainly muscular arterial branches could be base for collateral circulation. Symptoms and signs of occlusive arterial disease chronic course - usually ATS claudicatio intermittens pain at rest no pulse postural changes of the skin color temperature gradient bellow and above stanosis neurologic symptoms – paresthesis trophic changes of the skin, hair, nails atrophic muscles and soft tissues ulceration and gangrene – (dry, wet) Symptoms and signs of occlusive arterial disease acute course – thrombosis, embolisation, trauma dominant severe ischemic pain no pulse distal part below the stenosis is pale temperature gradient decreased filling of superficial venous system no trophic changes – there is no time for their development Occlusive arterial disease in patients with DM macroangiopathy – ATS (in DM patients is accelerated) - hypertension - hyperlipidaemia and dyslipidaemia - impaired nutrition of vessel wall because of dysfunction of vasa vasorum microangiopathy Damage of small diameter arteries and capillaries by generaliezed chronic complication of DM endothelial damage (diffusion of glucose into the cells, change into sorbitol, endothelial swelling – endothelial dysfunction....) In this group of patients – ischemic problems with lower extremities are very common, shifted to "younger" age, and are usually complicated by immunodeficiency and metabolic disorder /worse healing of wounds/ http://www.surgery.usc.edu/divisions/vas/legpainandlowerextremityarterialdisease.html Venous system of lower extremities http://www.chivatechnique.com/veins.php Blood flow in veins – lower extremities vis a tergo – rest of left ventricle ejection energy vis a fronte – suction of right atrium caused by up and down movement of AV junction negative thoracic pressure during inspiration craniocaudal movement of diaphragm corresponding changes of abdominal pressure horizontal body position rhythmic compression and decompression of deep venous system by muscles /walking/ valves plantar venous mechanism pulsation of commitant arteries Venous system of lover extremities superficial venous system (10% of venous returs) deep venous system (90% of venous return) system of perforating veins Physiological pattern of venous return from lower extremity: Function of the valves If the valves are working properly: they completely prevent pervasion of the blood from deep into superficial system they redirect central blood flow within the deep system they prevent retrograde blood flow from the upper level, if once the blood was ejected by muscle pump to upper level. During the muscle relaxation they completely prevent backward blood flow to more distal levels. Trombophlebitis Pathological process affecting mainly superficial venous system. Primary affection is inflammation of spa. vein by the process spreading from the surrounding tissue Creation of thrombus is usually secondary phenomenon superimposed to inflammation. Thrombus is fixed to the vein wall by fibrin connections between the thrombus and inflamed vessel wall. The process is usually localized to the site of inflammation, no or minimal systemic symptoms, only local signs of inflammation. No risk of emboli, b/c the thrombus if fixed onto the vein wall, and as well is localized within the superficial system. Deep venous thrombosis DVT - intravital coagulation of the blood inside the vessels - physiological mechanisms against thrombosis continual blood flow intact endothelium balance in production of pro and anti coagulating factors Impairment of those three mechanisms , known as Virchow´s trias has crucial role in pathogenesis of DVT. Predisposing factors for DVT history of DVT immobilization (slowness of venous return from LE DK) senior age (polymorbidity, dehydration, change of rheologic properties of the blood) obesity, malignity (production of procoagulating factors) heart failure, decompensation (venous congestion in backward failure) surgical procedures, trauma (release of tissue tromboplastin) pregnancy, puerperium, abortion (occlusion of pelvic veins by pregnant uterus, enhanced coagulation, tissue of trophoblast) Pathogenesis Slowing of the blood flow during immobilization, or in case of procoagulative status the blood there is a possibility of deposition of small amounts of fibrin at the site of vein valves The fibrin deposition is growing progressively by apposition of "new" fibrin fibers and platelets trapped into the fibrin matrix – formation of thrombus The thrombus is a serious occlusion, which impairs or completely blocks the venous return through the affected deep vein http://www.jaapa.com/cvi-and-pad-a-review-of-venous-and-arterial- disease/article/136677 / Venous return from affected extremity • the blood flow in central direction through affected vein is blocked by the thrombus •muscle contraction eject the blood into the surrounding deep vein /deep veins are usually doubled/ via anastomosis • this deep vein provide central flow of the blood, which is of course limited – so venous return as a complex process is impaired In this phase of DVT the blood does not flow into the spf. System, b/c perforators and their valves are not affected/destroyed, YET. Venous return in a stage of recanalisation Muscle contraction ejects the blood into three directions •through partially recanalized vein upwards • through anastomosis into surrounding deep vein •through perforating veins /which valves are destroyed/not working / into the spf. system. During muscle relaxation – spf. veins are emptying only partially into the deep veins, with sudden balancing of the pressure in both systems. Blood is cumulating in spf. veins – leading to permanent hypertension in spf. system and recanalized part of deep venous system. Venous return after total recanalisation Total recanalisation means healing of the vein, desobliteration, consequence of this process unfortunately is fibrotisation, or destruction of the valves. During muscle contraction the blood from deep vein is ejected into three directions -to SPF veins b/c of insufficient valves of perforating veins -to central direction through recanalised vein upwards -to central direction through surrounding deep vein Muscle relaxation: tendency for downward blood flow with rise of pressure in deep system, therefore emptying of spf. veins which had to be enhanced by the "suction" of negative pressure is limited http://www.nlm.nih.gov/medlineplus/ency/imagepages/2549.htm Consequences physiological pattern of venous return is affected onset of hypertension in spf. system and retrograde venostasis Venous congestion – consequence for the capillary balance Congestion leads to - rise of hydrostatic pressure at the venous end of the capillary - hypoxic damage to the endothelial cells - increase of capillary permeabilityh and therefore transudation of fluids into the pericapillary space Symptoms and signs of DVT - Depends on the level of deep system which is altered by thrombosis, crural thrombosis – pain, asymetric edema, fever – not so severe symptoms Ileofemoral level - severe pain - edema, feeling of "heavy" leg, - dilatation of superficial veins - skin is stretched, pale or cyanotic /according the progress of disease/ - phlegmasia alba/coerulea dolens - always fever, shivering, general symptoms, restlessness, anxiety Varices Cyllindric or saccular dilatation of spf. veins usually linked with relative valve insufficiency Primary varices Secondary varices Primary varices genetic predisposition, inherited insufficiency of connective tissue, abnormal collagen moleculle, The vein´s wall is weakened because of abnormal connective tissue, less tonus of muscular layer passive dilatation of the vein Supporting risk factors repeated increases of the pressure in spf. veins long lasting sitting, or standing without muscle contractions, obesity, pregnancy Secondary varices Always as a consequence of DVT, and valve damage – dilatation of vein enhances more and more relative insufficiency of the valves in perforating and spf. Veins Muscle contraction ejects the blood upwards, but also into the spf. system, what is not physiological - spf. venous hypertension http://www.chivatechnique.com/veins.php Chronic venous insufficiency CHVI – due to inappropriate venous return form the lover extremity as a consequence of severe impairment of hemodynamic mechanisms of venous return itself, is always linked with hypertension in spf. system Venous hypertension in lover extremities Retrograde venostasis with simultaneous imbalance of hydrostatic pressures within the capillary – Starling mechanism transudation of fluids into IST space edema endothelial hypoxic damage increase of capillary permeability transudation of proteins, RBC into he IST space fibrotic processes within IST space Symptoms and signs of CHVI pain – venous claudication, improves during elevation of extremity edema induration and thickness of subcutaneous tissue hyperpigmentation of the skin – caused by hemosiderine from RBC trapped and destroyed within the tissue trophic changes (sclerosis of the skin, ulcerations, scars after ulcers healing) – edema and fibrotisation limit transport of oxygen and substrates to the tissues, that´s why we have trophic changes ulcus cruris http://meded.ucsd.edu/clinicalimg/extremities_venous_insuf4.htm http://www.oculusis.com/mexico/is/varicose/varicose2.php Lymphedema Lymphatic system provide filtration of the blood, participates in immune reaction and production and outflow of lymph is a part of Starling balance. Lymphedema – edema of the tissue due to impaired production and/or outflow of the lymph. http://www.healingdaily.com/exercise/rebounding-for-detoxification-and- health.htm Lymphedema - no pain - in this case the fluid contains considerable amount of proteins Dysfunction of lymphatic system could be: inherited (inherited hypoplasia of lymphatic capillaries and vessels – Sy. Nonne – Milroy) , lymphedema is usually symmetric, affecting both extremities, in kids acquired (obstruction of lymphatic vessels or nodes by tumor, scar tissue, parasites, external compression, etc), lymphedema is usually asymmetric, mainly adults Mechanisms involved 1) static insufficiency of lymph. system – decrease of the transport capacity of the normal ly. system, volume of produced lymph within the tissue is normal /block of ly. flow/ 2) dynamic insufficiency of lymph. system – ly. system is intact, but is not able to drain lymph from the tissue, because of overproduction of the lymph - localized regional inflammation - venous congestion Lymphedema is chronic progressive pathological process - accumulation of the protein molecules within the tissue - edema (osmotic action of proteins) - chronic inflammation - fibrosis Consequence: fibrotic obliteration of ly. Vessels and/or nodes decreased transport capacity leading to total block of lymphatic flow – onset of blisters in affected area – repeated inflammations of the skin and subcutaneous structures – hyperkeratosis and papilomatosis of the skin Signs and symptoms soft edema of the extremity, dough like consistence touching or pressing with the finger can make several hollows, with slow alignment edema progressively gets more solid, creates folding typically it is not painful pallor, cold extremity, because of compromising of "normal" blood supply lymph edema could crate bizarre shapes, leading to deformation of affected part of the body Long lasting lymphedema could lead to secondary skin affection like repeated inflammations caused by spteptococcus sp., or trophic changes http://www.medsci.org/v07p0353.htm


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Specialist equipment and materials for scientists working at the nanoscale. Includes material synthesis, analytical equipment, and applications.
B&W Tek Announces New Enhancements to NanoRam Handheld Raman Spectrometer
B&W Tek, Inc., an advanced instrumentation company that delivers lab quality Raman spectroscopy solutions through user-friendly mobile platforms, is pleased to announce new enhancements to its NanoRam® handheld Raman spectrometer.
New, High-Speed EMCCD Cameras Provide Exceptional Low-Light Imaging Performance weblink
Trenton, New Jersey Princeton Instruments is pleased to announce the immediate availability of the ProEM®-HS line of high-speed EMCCD cameras with patented eXcelon®3 technology (X3) for low-light imaging and spectroscopy applications.
RHK Technology, Inc. announces the release of PanScan-Freedom LT weblink
The PanScan-Freedom LT is an innovative new closed-cycle cryogen-free system for stable low temperature performance, unprecedented low drift, exceptional spectroscopy performance, and atomic resolution in a surprisingly compact, simple, and affordable package.
One Instrument for Raman, UV-Visible-NIR and Fluorescence Spectroscopy of Microscopic Samples weblink
The 20/30 PV™ gives you the ability to collect UV-visible-NIR absorbance, reflectance, fluorescence and Raman spectra of microscopic sample areas. This is in addition to UV-visible-NIR imaging, film thickness measurements and micro-colorimetry.
High Resolution Spectrometer weblink
Spectrometer specialist McPherson introduces a new high-resolution spectrometer system with Pico meter resolution capability.
PHOTONIS Introduces NOCTURN Color Low-Light Camera
USB3 Functionality with Day/Night Imaging
From Mechanical Engineering to Particle Accelerators: Hexapods and Their Fields of Application download weblink
Today, many automation technology sectors require highly precise positioning systems. For multi-axis solutions, parallel-kinematic systems often are the perfect choice. Hexapods are a good example for this, where the travel ranges go from only a few to several hundred millimeters.
Piezo Linear Drives for Laser Technology: Automatic Mirror Positioning in Vacuum and in Inaccessible Place download
Lasers are versatile tools with a wide range of applications.
Park NX-Wafer for Wafer-Fab Manufacturing Fully Automates Semiconductor Industry's Bare Wafer Automated Defect Review Process, Increases Throughput by 1,000 Percent weblink
Park Systems, announces Park NX-Wafer, a revolutionary AFM design for bare wafer manufacturing that fully automates the automatic defect review process and increases production throughput by an astounding 1,000%.
Small size and high resolution for 10-6 hPa: Miniature stage only 24 mm wide with a resolution of 0.5 nm
Physik Instrumente (PI) has now introduced vacuum-compatible versions of the LPS-24 series: Under vacuum conditions down to 10-6 hPa, the miniature stages of only 24 mm in width achieve a sub-nanometer resolution over a travel range of 15 mm.
Waveguiding and detecting structure for surface plasmon polaritons on silicon
(Toyohashi, Japan, 25 June 2014) Toyohashi Tech researchers have developed a simple, low-loss waveguide for Surface Plasmon Polaritons (SPPs) that is applicable to nanoscale photonic integrated circuits on silicon.
Nanotech France 2015 International Conference & Exhibition
June 15 - 17, 2015, Paris - France
2nd Edition Nanotech Dubai 2015 International Conference & Exhibition
March 16 - 18, 2015, Dubai - UAE
MicroSense ships Novel LED Sapphire Wafer Measurement Tools for Process Control
MicroSense, LLC, a leader in non-contact wafer metrology systems, today announced multiple shipments of its new, next-generation automated sapphire wafer metrology tool, the MicroSense UltraMap C200.
Conference Review: 11th Confocal Raman Imaging Symposium
Many international researchers joined the 11th Confocal Raman Imaging Symposium from September 29th to October 01st 2014 in Ulm, Germany.
Oxford Instruments Asylum Research Hosts a Webinar October 21st: "There's No Other AFM Like Cypher™: Recent Technological Advances" weblink
Oxford Instruments Asylum Research, the technology leader in Atomic Force Microscopy, will host a free webinar October 21st, "There's No Other AFM Like Cypher: Recent Technological Advances."
JPK report on the use of the NanoWizard® AFM system at TU Braunschweig to study the properties of DNA and DNA nanostructures
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the use of their AFM system, the NanoWizard®, in the Nanobiosciences Group of the Institute of Physical & Theoretical Chemistry at the Technical University of Braunschweig.
Nanoparticles give up forensic secrets
Research article taken from IOP Publishing's journal, Nanotechnology
Measure Both Elastic and Viscous Properties with AFM Using Asylum Research's Exclusive AM-FM Viscoelastic Mapping Mode
Oxford Instruments Asylum Research announces the availability of its powerful new nanomechanical imaging technique, AM-FM Viscoelastic Mapping Mode, for its entire line of Cypher™ and MFP-3D™ atomic force microscopes (AFMs).
First-order-reversal-curve measurements of nano-magnetic materials weblink
The magnetic characterization of nanoscale materials is usually made by measuring a hysteresis loop. It is not possible to obtain interaction or coercivity distribution information from the hysteresis loop alone, however.
N-Series Vacuum Valves
N-Series vacuum valves are available in both right angle and in-line formats in flanges sizes NW16 to NW50


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ICYMI: Twins' Glen Perkins Weather-Bombs Forecast
The Twins' Glen Perkins dropped in on Mike Augustyniak's weather forecast on Tuesday at noon (1:03).
WCCO This Morning - July 31, 2013
WCCO This Morning - July 31, 2013
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Funny Videos, Crazy Videos, Fun Games
Tron Light Cycles Classic Tron Game
Do you remember the movie and video game from the 80's called Tron? This is the part of the game where you drive a light cycle and try to kill your opponent.
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Is This the End for Kourtney Kardashian and Scott Disick?by Hilton Hater at . Comments
We've heard about it for years regarding Kourtney Kardashian and Scott Disick: the end is near, the break-up is imminent, he's a total and complete douchebag.
But a new tabloid cover story implies an impending split between the reality star and her baby daddy for a brand new reason: Disick's shady, law-breaking father.
It's come to the attention of Kourtney and her family that Jeffrey Disick - Scott's 62-year old father - recently turned himself in to the Suffolk County (N.Y.) District Attorney's Office in the wake of grande larceny allegations. He stood accused of stealing money from a Long Island bank.
Jeffrey eventually pleaded guilty to a misdemeanor charge of petty larceny, paid $6,500 in restitution and was sentenced to 140 hours of community service.It's not a coincidence, Star reports, that Scott's parents have been so rarely seen since the debut of Keeping Up with the Kardashians in 2007.
"They're completely removed from the Beverly Hills scene and look like fish out of water when they're with Kris and her glamorous girls," a Kardashian source tells the magazine.
Are the shady financial transgressions of Scott's parents - they have been the subject of liens and judgments filed by companies, individuals and state and federal tax agencies totaling approximately $391,000 - enough to prompt a break-up? Not on their own.
But Disick and Kardashian have been fighting for a long time.
"Scott doesn't even really have a career outside reality TV, and there have been so many stories about Scott's out-of-control partying and wandering eye," the insider says. "When this secret about his father's criminal past gets out, Kourtney will feel like Scott's betrayals are never-ending - to her and her entire family."
Do you think Kourtney should dump Scott?
@luwala try using correct spelling if you are able this is not a fu cking third world country yet. talk like a human and not a meth head
Let Him who is without sin be the first to cast a stone. Pls let them be
HA...HA... This is too funny, as if the preggy "Kar"TRASH"ian" has any morals or dignity to do it! We all know she's more desperate than Kim or Kourtney... ha...ha...ha.. so so funny!
Its tym u statd thkn lyk maturd pipo.u ar a family nw wth kids(childrn) dnt let the public benefit frm yo problems.let such thngs b sotd in doors nd pipo will respct u in one way or th othr.
Pimp mom need to stop pimping her kids out to keep viewers watching their reality show. Ratings must be down a lot for her to scrape the bottom of the barrel with this story. What Scott's parents did have nothing to do with him and Kourtney. The Kardashian family should NEVER talk about any family being shady.
When Kris Kardashian is saying you are classless and embarrassing, you know you got it bad.
They need to keep their private life private. If you air your dirty laundry, you are asking for trouble. Keep it to yourself and work through your problems rather than making them public and having everyone hate one or the other. Time to grow up when kids are involved.


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The LG938L and LG959 wheel loaders, with 2.4 and 4.0 sq yd bucket capacity, respectively, are easy to operate and are ideal for material production facilities and site preparation and maintenance yards. They include an ISO-interface hydraulic quick coupler for easy attachment change-outs from inside the cab and full-powered third function hydraulics.
SDLG North Americawww.sdlgna.com
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Optional Active Bouncing Control (ABC) feature prevents operators from damaging the...
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Like the other two updates to the company's H Series, this machine's Hystat control...
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The Royal ROY TP 16 Aluminum 16" x 2" Tapered Deep Dish Pizza Tray is an excellent piece of cookware for baking and serving your delectable pizzas. This 2 inch deep pizza pan with a tapered side is perfect for extra thick crusts and the wide rim allows you to remove pizza slices effortlessly. Pizza Tray, 16" x 2", tapered deep dish, Aluminum
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Experienced Pharmaceutical / Lab Sales: Urine Drug Testing
viaDermic™ Toxicology, LLC is a national sales and marketing organization that provides Healthcare Practitioners access to urine drug testing (UDT) and other laboratory services.
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Tech Helproom
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BBC iPlayer startup default
Likes # 0
Posted May 18, 2011 at 8:21PM
Is it possible to stop BBC iPlayer loading automatically at startup? I cannot see any reference to the programme in the list of startup items but it always appears when booting up.
Likes # 0
Posted May 18, 2011 at 8:27PM
Start the Player and then top left you should see a box marked Preferences. Click on this and untick the box under Startup . Then click Save.
Likes # 0
Posted May 18, 2011 at 8:28PM
SORRY !!! Should have said top right.
Likes # 0
Posted May 18, 2011 at 8:30PM
Two places to check....
- Start - Run - msconfig - Startup. Disable if found.
- Start - All Programmes - Startup folder. Delete if found.
Likes # 0
Posted May 18, 2011 at 8:31PM
iscanut You are, of course, correct!! I'd forgotten about that method - apologies.
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Posted May 18, 2011 at 9:11PM
Thanks iscanut. It is all a question of knowing where to look.
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Miguel Montero placed on the disabled list
Aug 1, 2013, 5:44 PM EST
Miguel Montero has had a bad back for some time. It's gotten too bad so the Dbacks are placing him on the 15-day disabled list. Wil Nieves will take over backstop duties in Arizona.
Given Montero's track record I fully expect him to give an interview in two weeks in which he tells us, in no uncertain terms, what he thinks of that freakin' stupid, chickens**t, immature disabled list.
- Arods Other Doctor - Aug 1, 2013 at 6:09 PM
Did the Diamondbacks come over and TP your house or something? Why the constant hate? Just curious, but to me they're not nearly relevant enough to hate as much as you do. Maybe it's because they knocked the Braves out of the playoffs in 2001?
- CyclePower - Aug 1, 2013 at 6:35 PM
Think Ian Kennedy's headhunting, Brawlgate and Montero's public comments about Puig that place him squarely in the Papelbon douche category.
- Arods Other Doctor - Aug 1, 2013 at 7:52 PM
Think about the constant lame-ass quips about grit and a constant insistence about how stupid all of their moves are (CC has written at least 3 times how terrible the contract for Aaron Hill was.) Name any team in baseball and I could point out at least six things they've done that are stupid, and yet Craig has a giant boner for the Diamondbacks why? I don't care, I just don't get it. I understand hating the Yankees or Red Sox or Phillies … but all those teams have been relevant with at least some consistency.
Also, just fyi, Kennedy doesn't have the control to be a headhunter. If he's come within twelve inches of hitting a target all year it was just blind luck. This isn't Pedro cruising along with amazing command and then mysteriously letting one get away. This is pitch after pitch having virtually zero control. I'm sure he's tried to hit hitters and I know he went at Greinke, but to imply he tried to hit him where he did is to claim he has good control. And that's just plain stupid.
- Craig Calcaterra - Aug 1, 2013 at 8:02 PM
I don't hate the Diamondbacks at all. I think the "grit" thing was dumb. I think Miguel Montero should probably stop talking smack about people. But they don't bother me a bit in any actual way.
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Leopard is a neutral. Polka dots, too.
Kris Atomic
A little illustrated me that I drew for Boden earlier in the year. Wearing head to toe Boden...
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Medley of drawings, photos and anything else I find pleasing to the eye.


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I can balance a budget
Michigan Constitution requires the government to have a balanced budget.If I can balance a budget then why can't the leaders of the country?Since Michigan does not have a balanced budget,
Michigan Constitution requires the government to have a balanced budget.If I can balance a budget then why can't the leaders of the country?Since Michigan does not have a balanced budget,
If your boss told you that your evaluation score shows you have an 18% approval rating on the job performance, do you really think you would be up for a
First, why does anybody watch, let alone go on The View? Today John McCain did just that, and in a conversation regarding abortion, said he would prefer to have Roe
Northwestern University's alumni magazine arrived today. Flipping through the NewsOnCampus section, this headline jumped out at me: Rethinking the Electoral College, penned by one of the current students.In the brief
One of the most stubborn areas of political debate today concerns the Supreme Court and its power to legislate or "interpret the law" as they prefer to call it. The
Everybody is going nuts over how the DNC is split this year in Denver. Will Hillary publicly release her delegates? Will there be a full roll call vote? Will Clinton-backers
Is direct suffrage for the Vice Presidency the last obvious unturned stone of the American enfranchising movement? The original Constitution did not let people vote directly for President, Vice President,
75 Days until Election Day August 21, 2008QUOTE OF THE DAY:"We agree with the Attorney General that the proposal affects the "foundation power" of government "- Court of Appeals in a
Recently, there has been some talk about John McCain potentially offering a one-term Presidency pledge. I, and the term-limiting Twenty-Second Amendment to the Constitution, think that such a thing is
**Look at the past to see the future.One thing for sure is the next four years will be different, possibly more than any of us can imagine. What do you
Originally posted at Random Rants from an Airline EmployeeThe problem with the GOP is that you get people sporting the label who really aren't for limited government. In fact, there
Cross posted at Random Rants from an Airline EmployeeThis past December, I wrote a pretty lengthy piece on No-Knock warrants, and why they are not only unconstitutional, but just plain
These responses to the Sedition Acts of 1798, which limited anti-government speech in the wake of the Quasi-War with France, were authored by Thomas Jefferson and James Madison and passed
With the Russian-Georgian conflict erupting over South Ossetia, I figure it's a good time to recall the history of the Union-Confederate conflict over West Virginia. No, the situations are not
Good old Dennis Kucinich is back in the news with his Bush impeachment attempt, claiming that he goaded Congress into voting for war with Iraq by using false claims. Given


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Ma is just a weird-looking dude.
Dear Mr Ma, dont be misunderstood in your country, it could cost you a lot ... CCP is watching you and your other internet friends. You bring too much freedom to the minds of this nice country.
Can this monkey stop making fun of himself in front of the whole world? no one misunderstood him and no one cares what he said and did. He is the last person who can talk about creditability, customer value, etc.- the way he screwed up yahoo and other investors showed his personality very well.
The problem for Jack Ma: actions speak louder than words.
Nothing to misunderstand about Capt'n Jack, as Alibaba is a copycat site of Amazon.com and E-Bay in my opinion!
Nothing to misunderstand that the name 'Alibaba and the 2,236 Thieves' was justified too, when the B2B company CEO David Wei and COO Elvis Lee Shi-Huei resigned when rampant fraud became exposed back in February!
No misunderstanding when Ma secretly switched Alipay without notifying its investers of the move; especially, Yahoo who owned 43% of the stock!
Now Capt'n Jack is moving towards opening a mobile operating system in China! Anyone care to guess how similar it will be to google's Android software or Apple's iOS software for that matter?
This guy is a total representative of the typical chinese 'innovative' mindset in the country today.................................................Receive & Duplicate!
This is why China won't see a Steve Jobs born in their country!
Jack Ma is the definition of SHANZHAI!
that means he will do ANYTHING, fair/unfair, legal/illegal to accomplish his objectives. The end always justifies the means here....
Yeah he's really misunderstood. Alibaba is an interesting site though. You just have to be aware of what you are doing. Be cognizant of scams etc. If you are looking to get your feet wet in the mess that is international business you can get your knock downs out of the way there.
Jack Ma is great to china internet
A quick not on innovation, re OODA comment. EBAY and Amazon are not necessarily innovative. They are better versions of what came before. Everybody copies everyone else on the Web, and that is what is wonderful about it and drives innovation. As to operating systems, Android is Linux, so it is already a copy, with enhancements, through the Open Source route, which has a similar pattern. China is a culture of innovation that invented gunpowder, rockets, and paper money--among other things. As a culture, they are now quickly moving forward in scientific publishing, in patents, and in capability to quickly integrate diverse technologies. If you suppose that you have a native cultural advantage, then, you would be very much mistaken. Wakey, wakey, as the hypnotist says.
China's Communist party wants to remain in the driver's seat when it comes to managing morality in society--even during the country's annual auto shows.
As Xi reaches his two-year anniversary Communist party chief, he has displayed remarkable resolve in his efforts to be a different leader for a different China. The still-unanswered question is whether being different will be enough of a change, or too much.
Michael O'Hanlon: Taken together, the two military accords reportedly near completion could substantially reduce risks in the security sphere that could threaten the entire U.S.-China relationship.
News out of Beijing that China and Japan have decided to move closer to dialogue on territorial disputes in the East China Sea is likely be to welcomed by everyone, with one notable exception.
As U.S. President Barack Obama gets ready to meet Chinese President Xi Jinping following the Asia-Pacific Economic Cooperation summit in Beijing next week, relations between the world's two largest economies are mired in a troubling inertia.
China Real Time Report is a vital resource for an expanding global community trying to keep up with a country changing minute by minute. The site offers quick insight and sharp analysis from the wide network of Dow Jones reporters across Greater China, including Dow Jones Newswires' specialists and The Wall Street Journal's award-winning team. It also draws on the insights of commentators close to the hot topic of the day in law, policy, economics and culture. Its editors can be reached at firstname.lastname@example.com.


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Start learning with our library of video tutorials taught by experts. Get started
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Explores the nuances of creating and distributing interactive forms using Acrobat 9 Pro.
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