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Chess DVD Collections
The Modern Defence is a tough system based on counterattack. In this new three-volume Foxy Openings series IM Andrew Martin maps out a repertoire for Black for use by players of any level. The Modern creates difficult positions which are ideal if you want to play to win with Black.
E-DVD FOXY OPENINGS - VOLUME 109 - Modern Defence Repertoire for Black Part 2
A darling of great attacking players such as Marshall and Spielman, the Danish Gambit has recently been revived by GMs Hector and Tisdall. They have successfully challenged some of the old assessments of the line, and in this video, GM Nigel Davies tells you all you need to know to wield the sizzling Danish with deadly effect!
E-DVD FOXY OPENINGS - VOLUME 21 - Dashing Danish
This is one of the most instructional DVDs Roman has ever produced and is highly recommended for all players as well as coaches. The Russian school of Chess has produced, through a formula of methods and patterns, some of the greatest players of all time.
ROMAN'S LAB - VOLUME 64 - Russian School of Chess - PART 3
Susan will take you through 8 easy to follow, highly instructive games covering the basic principles of chess. This will help your understanding of chess and is guaranteed to improve your chess game. She will show you how to avoid the most common mistakes made in chess and give your chess game a strong, fundamentally sound foundation.
WINNING CHESS THE EASY WAY - VOLUME 1 - The Basic Principles of Chess
FIDE Senior Trainer and IM Andrew Martin follows up the Vol. 119 - Anti-Gambit Guide 1.E4, with this latest and all-new DVD for Foxy Openings, providing more antidotes to all of the most commonly-played gambits after 1 d4 and suggests that there is nothing to fear after all, as long as you treat these openings with respect.
E-DVD FOXY OPENINGS - VOLUME 120 - Anti-Gambit Guide for 1. d4
On this DVD, IM Andrew Martin presents an ultra-modern and aggressive repertoire for Black that sidesteps the over-analyzed lines. By following these recommendations Black can secure all the dynamic advantages of King's Indian play with a repertoire that is on the cutting edge of theory.
E-DVD FOXY OPENINGS - VOLUME 29 - King's Indian 2
Part of the Roman and Rybka, Perfecting the Opening Series by Grandmaster Roman Dzindzichashvili and Grandmaster Eugene Perelshteyn, who use the world computer champion Rybka to bring you new lines, secrets and novelties in the Grunfeld.
The Grunfeld is a dynamic opening that is used by aggressive players with Black to steal Whites initiative by counterattacking its pawn center.
ROMAN'S LAB - VOLUME 72 - The Complete Grunfeld Defense with New Secrets and Novelties - PART 1
It is always nice to win a game quickly. But some opening traps are based only on hopes that the opponent will make a serious mistake. If the opponents play correctly, the trap could backfire. On this DVD Susan will take you through a number of opening traps & short games.
WINNING CHESS THE EASY WAY - VOLUME 4 - Learn How to Avoid Opening Traps and Pitfalls
On disk 1, Susan shares with you three of her best and highly instructional games on how a grandmaster thinks, reasons and approaches each move. This DVD will help you to take these easy to follow ideals and principles and apply them to your own games.
On disk 2, the Polgar sisters Susan, Sofia and Judit, along with their parents give their first public appearance in over 10 years.
E-DVD WINNING CHESS THE EASY WAY - VOLUME 6 - Secrets on How to Think like a Grandmaster
IM Andrew Martin presents potentially deadly set-ups for White when the Morra Gambit is declined.
E-DVD FOXY OPENINGS - VOLUME 37 - Morra Gambit Declined
Not much has been changed in those openings in past 30-40 years. With the help of Rybka , Roman injects new life in those ancient openings giving some original approach understanding of initiative and sacrifice of a pawn.
ROMAN'S LAB - VOLUME 80 - Reversing of Well Established Evaluations in the Giuoco Piano & 2 Knights Defense
Sicilian expert GM Chris Ward recommends dynamic lines for Black against all of the anti-Sicilian systems.
Part 1: 2.c3
Part 2: 2.Nf3 d6 3.c3
Part 3: Closed & Fianchetto Systems - 2.Nc3 & 3.g3/2.g3/2.Ne2/2.b3
Part 4: Grand Prix Attack - 2.Nc3 & 3.f4
Part 5: 2.Nf3 d6 3.d4 cxd4 4.Nxd4 Nf6 5.f3
Part 6: 2.Nf3 d6 3.d4 cxd4 4.Qxd4
Part 7: 2.Nf3 d6 3.Bb5+/3.c4
Part 8: Smith-Morra Gambit & Wing Gambit Ward blasts holes in systems favored by many club players!
FOXY OPENINGS - VOLUME 8 - Beating all the Anti-Sicilian Systems
The French Defense: Guimard Variation is a chess opening 3... Nc6 is known as the Guimard Variation: after 4.Ngf3 Nf6 5.e5 Nd7 Black will exchange White's cramping e-pawn next move by ...f6. However, Black does not exert any pressure on d4 because he cannot play ...c5, so White should maintain a slight advantage, with 6. Be2 or 6. Nb3.Grandmaster Guimard was a 3 time chess champion in Argentina.
The French Defense: Guimard Variation - Chess Lecture - Volume 55
In the 6-Disk Collection of Roman's Encyclopedia of 47 Essential Chess Openings, Roman gives you his preferred lines for white and black that will give you easy and quick to learn lines that provide a clear plan to solve your opening problems.
ROMAN'S LAB - VOLUME 117 - Encyclopedia of Chess Openings - PART 6
England's most dedicated Dragon warrior - GM Chris Ward - presents his complete up-to-date Dragon repertoire including antidotes to the topical white systems. No other defense can match the Dragon for thrills and spills. A highly entertaining two hour plus epic.
E-DVD FOXY OPENINGS - VOLUME 45 - Sicilian Dragon
On this DVD, Grandmaster Roman and Rybka will give you a thorough understanding of the Accelerared Dragon for black. Roman has selected a number of typical Accelerated Dragon games, the kind that you might experience in your own games for maximum education value.
ROMAN'S LAB - VOLUME 88 - Highly Instructive and Educational games for the Accelerated Dragon Player
Roman's lab presents Volume 11 - The Greatest Games of Chess - Positional and Tactical Masterpieces (Part II, 7 games) Roman selects and analyzes 7 of the greatest games ever played by the top world-class players.
ROMAN'S LAB - VOLUME 11 - Greatest Games of Chess Ever Played - PART 2
Repertoire for White with 1.d4. The tentacles of the Trompowski now reach out to 1...d5, keeping those Slav and Queen's Gambit players off balance. Independent theory developed by super-grandmasters that you will struggle to find in opening books!
E-DVD FOXY OPENINGS - VOLUME 53 - Trompowski-Pseudo
On this DVD, Grandmaster Roman Dzinzichashvili clearly outlines extremely dangerous lines for black in the Petroff Defence. Evolution of this dangerous line for black is easily explained based on games of the top Grandmasters and careful analysis by Roman.
ROMAN'S LAB - VOLUME 96 - Highly Instructive & Educational Games to Dismantle the Petroff Defence at the Highest Level
With Roman's help, you will have the ability to recognize tactical themes, patterns and combinations, enabling you to use them to win your own games. Roman will guide you through a variety of different themes, mating nets and opening sacrifices that will materialize out of nowhere.
ROMAN'S LAB - VOLUME 15 - Improve your Combinational Preparation and Tactical Skills - PART 2
Another radical collection of devilish lines. Grandmaster Nigel Davies recommends more devious systems to generate devasting attacks right out of the opening. Armed with these lines, dont expect to win any friends. What you will win is your games - in brutal and dramatic fashion!
E-DVD FOXY OPENINGS - VOLUME 61 - Dirty Tricks #2
On this very powerful DVD, Roman updates his original crushing lines material Vol. 33. With the aid of Rybka, Roman has created new deadly lines against the Alekhine, French, Caro-Kann and a new Gambit to play against the center counter which Roman created!
ROMAN'S LAB - VOLUME 103 - Winning With New Attacking Lines Against Highly Popular Openings
The King's Indian is one of the biggest openings in modern chess theory. Roman will give you the best lines for Black to play against all of White's responses. This will get you reasonable positions and a clear plan to follow. Roman will teach you how to play one of the most aggressive openings for Black.
ROMAN'S LAB - VOLUME 21 - The Easy Way to Play the King's Indian Defense
In the mid-1960s, Bobby Fischer unveiled a new wrinkle in his beloved Ruy: The Exchange Variation. He showed it was not the virtual drawing line it had once been thought to be. IM Andrew Martin takes a look at this line arising after 1 e4 e5 2 Nf3 Nc6 3 Bb5 a6 4 Bxc6.
E-DVD FOXY OPENINGS - VOLUME 69 - Fischer's Deadly Weapon - Exchange Ruy Lopez -
White playing the Queen's Gambit can make it very versatile. On this DVD, Roman will bring you a variety of plans using highly instructional games. Using his own games as well as other top GM's, Roman will teach you different ways to play one of the oldest Versatile Openings to date.
ROMAN'S LAB - VOLUME 111 - Highly Instructionial Games in The Queen's Gambit Declined
In this DVD, IM Andrew Martin presents an ultra-modern and aggressive repertoire for Black that sidesteps the over-analyzed lines. By following these recommendations Black can secure all the dynamic advantages of King's Indian play with a repertoire that is on the cutting edge of theory.
The King's Indian 1 covers the Samisch Variation, Four Pawns Attack and the Fianchetto Variation (White plays g3).
FOXY OPENINGS - VOLUME 28 - King's Indian 1
The Sicilian Kan is the most flexible and easy to play variation of all the lines in the Sicilian. On this DVD, IM Andrew Martin will teach you how understanding certain principles and development will help you master this dependable repertoire for Black.
E-DVD FOXY OPENINGS - VOLUME 77 - Sicilian Kan
In this all-new three-volume set on the Pirc Defence, International Master and Senior FIDE Trainer Andrew Martin demonstrates that Black gets dynamic play after 1...d6, 2...Nf6 and 3...g6. This is an opening well-suited to the needs of the club player.
FOXY OPENINGS - VOLUME 125 - The Dynamic Pirc Defence - g3 systems,Bg5,and Bf4 - Part 2
The Dragon variation is considered to be one of the sharpest openings in chess. Made popular due to its aggressive nature, it is little wonder that the Dragon has attracted the likes of world number one Magnus Carlsen as one of its enthusiasts.
Killer Dragon - DVD 1 with Grandmaster Simon Williams
This chess DVD is an in-depth analysis of the Berlin Wall opening. It starts with some side variations and moves chapter by chapter towards the main position of the opening – the Berlin Endgame. While working on this DVD, my intention was not only to provide the listeners with detailed variations, but also to help them achieve deeper positional comprehension about how to play this unique type of opening struggle.
Battle with the Berlin Defense - EMPIRE CHESS
This dvd will help you the next time you are sitting across from your opponent and not sure what your next move is. You will gain confidence by learning about strategy and ideas to look for to create a plan. A plan may consist of a Pawn Minority attack, controlling the center or just improving your pieces.
E-DVD FOXY OPENINGS - VOLUME 85 - Essential Chess Tactics Easily Explained
2 DVD Collection
IM Valeri Lilov is a young chess talent from the small European country of Bulgaria. He currently resides in Varna, Bulgaria and works hard in the field of practical chess and chess pedagogy.
Positional Chess - Chess Lecture - Volume 35
On this DVD Roman, together with Eugene Perelshteyn and assisted by the world's strongest software, Rybka, have re-invented the 3...Qd6 Scandinavian. This opening is the best unexplored and underestimated weapon available for Black in a long time. What makes this opening so inviting is there is not much to learn, easy equality is obtained, and it can't be refuted, while also being rich with tactics and counter play and hidden traps.
ROMAN'S LAB - VOLUME 40 - Encyclopedia of Chess Openings - PART 4
The most difficult phase of the game for beginner chess players is the middlegame because it is a constant time of transition, maximum tension, and a time of combining immediate tactical needs with long-term positional ideas. Most middlegames contain nearly all of the pieces still on the board, and the friction between opponents inevitably creates conflict, requiring complete attention to avoid forcing combinations. This chess video/DVD features hours of extremely high-quality instruction by experienced chess trainer Grandmaster Damian Lemos, reviewing the basic concepts of the middlegame and how to apply them successfully in your own games.
Play the Middlegame Like a Grandmaster - PART 2 - EMPIRE CHESS
The Modern Stonewall Dutch is an ideal opening for club players, offering Black the twin values of solidity and dynamism. The Stonewall has been tested extensively at Grandmaster level and has passed every test with flying colors. Black's set-up is sturdy and solid, but most certainly not passive.
E-DVD FOXY OPENINGS - VOLUME 93 - The Modern Stonewall Dutch
With this video Black can now look forward to facing the Torre Attack, the Trompowski, the Colle System, the Stonewall Attack and the Veresov System. IM Andrew Martin sorts out uncompromising and approved systems for Black against all of these annoying White d-pawn systems
E-DVD FOXY OPENINGS - VOLUME 5 - Annoying d-Pawn Openings


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A bible study examining eternal security, Introduction. how are christians saved? there is a common misconception that christians who do not believe in eternal security are saved by good works.. The blogoshiur: god multiverse (part 13: eternal, On a humorous note, we would like to share one of our favorite multiverse scenarios which is also a model of eternal inflation. we think it is a far more plausible. Ronald reagan | white house, Ronald reagan . at the end of his two terms in office, ronald reagan viewed with satisfaction the achievements of his innovative program known as the reagan.
Eternal sunshine spotless mind - wikipedia, , Eternal sunshine spotless mind 2004 american romantic science-fiction comedy-drama film estranged couple erased . http://en.wikipedia.org/wiki/Eternal_Sunshine_of_the_Spotless_Mind The bangles --- eternal flame - youtube, Susanna hoffs-bangles-eternal flame-. http://www.youtube.com/watch?v=XwajTekSAcM Klf - 3 eternal (complete) - youtube, Video song 3 eternal (klf). http://www.youtube.com/watch?v=LXEOESuiYcA

subset: commoncrawl


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The mission arm of the Presbyterian Church (U.S.A.) plans to send out a letter of apology for the sexual and physical abuse that was endured by dozens of people out on the mission field.
The denomination had received 85 reports alleging abuse – incidents that spanned a 40-year period and on ten different mission fields.
Linda Valentine, executive director of the General Assembly Mission Council, expressed horror and the church body's deepest apologies as it released a detailed report last week. more >>
A Presbyterian regional court has affirmed a Wisconsin church body's decision to ordain a partnered homosexual.
The Permanent Judicial Commission of the Synod of Lakes and Prairies ruled Saturday that the John Knox Presbytery "acted within its authority" when it approved the ordination of Scott D. Anderson in February.
A complaint had been filed in March by Caledonia Presbyterian Church in Portage, Wisc., as well as the presbyteries of Central Florida, Prospect Hill and Stockton, alleging that John Knox Presbytery committed irregularities by ordaining someone who is ineligible. more >>
A California minister was rebuked on Friday by a Presbyterian Church (U.S.A.) court for performing same-sex ceremonies.
In a 4-2 vote by the Redwood Presbytery Judicial Commission, the Rev. Jane Adams Spahr was found guilty of representing the ceremonies as marriages, persistently disobeying church law, and violating her ordination vows.
An anonymous layperson had brought charges against Spahr, a lesbian activist and a Presbyterian minister for 36 years, after she officiated the weddings of 16 same-sex couples during the brief period same-sex marriage was legal in California between June and November 2008. more >>
A retired Presbyterian minister is facing trial Tuesday morning for performing same-sex ceremonies in California.
This is the second time the Rev. Jane Adams Spahr, a lesbian activist, has gone to court over violation of church law.
Earlier, in 2008, she was cleared of wrongdoing by the Presbyterian Church (U.S.A.)'s highest court, the General Assembly Permanent Judicial Commission. The high court had reversed a decision by a regional judicial committee that found Spahr guilty of misconduct when she conducted ceremonies for two lesbian couples in 2004. more >>
The Board of Pensions of the Presbyterian Church (U.S.A.) is considering a recommendation to extend spousal and dependent benefits to same-gender domestic partners.
The board is hoping to bring proposals next year and begin implementing changes to the denomination's Benefits Plan in 2012.
Thomas C. Paisley, Jr., chair of the Board of Directors of the Board of Pensions, said they are committed to "responding affirmatively to the action of the General Assembly, with a focus on doing what is in the best interests of our members and being attentive to the concerns of our participating employing organizations," as reported by the Presbyterian News Service. more >>
The Presbyterian Church (U.S.A.) approved a significantly modified version of a Middle East report on Friday that, for the most part, placated both Jews and Palestinians.
Avoiding what could have been devastating to Presbyterian-Jewish relations, the church's General Assembly overwhelmingly passed a report by its Middle East study committee that removed more objectionable language.
Gone was the recommendation to divest from the Caterpillar company, whose bulldozers are used by Israel to demolish Palestinian homes. Instead, the church "strongly" denounced the Caterpillar company for allowing its products to be used in non-peaceful ways by Israel. more >>


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Archive for the 'home decor' Category
Every year, around Christmas time, I get a new calendar (or two) to get a jumpstart on the new year. Is it me or is there something about a new calendar and a new year that makes you feel like absolutely anything is possible?
So I rounded up eleven of my favorite calendars to give you the kick in the pants you need to start thinking about 2014…
1. 2014 minerals calendar from Lindsay Jones
2. sung calendar 2014 from Snug.Studio
3. 2014 astrology wall calendar from Prismatic Print Shop
4. 2014 Frankie magazine calendar from Frankie Press
5. oversized wall calendar for 2014 from One Canoe Two
6. 2014 Scandinavian floral calendar from The House That Lars Built
7. 2014 prisms calendar from Julia Kostreva
8. 2014 calendar from Linda & Harriett
9. big number 2014 calendar from Decoylab
10. 2014 'Ain't nobody got time for that' calendar from Cranny
11. 2014 Stendig calendar from Need Supply
Don't see your favorite calendar listed? Leave a link to your faves in the comments below. Always up for discovering a few more.
P.S. Brittany from The House that Lars Built is giving away a Public bike today, as a part of the 24 Merry Days giveaway event! Enter to win the bike here.
I love natural wood, and my first instinct is always to create a wood wall that looks as natural as possible. But I've seen some great painted walls lately, and know that there are times when painting your slat or tongue-and-groove wall surface really is the right call. The great thing is that painting gives you a large range of options. From white beachy horizontal boards to a dark Japanese look with deep blacks, you can give your wood wall some personality.
Maybe you have wood walls and love the texture, but the color of the wood doesn't go with the rest of your decor. Or perhaps you already have copious amounts of wood in your interior, and need to provide a little visual relief. Painting your wood wall might be just the ticket. Don't forget great options like a warm grey, or even a color if you're being a bit daring. Or try one of the new lookalike wallpapers! And if you don't really want to cover all that natural grain, a stain or wash in a similar tone can be just as lovely.
Do you love wood, and can you stand to cover it up?
(above) Black Vertical Boards
Vertical White Kitchen + Window Seat
Textured Grey Boards + Matte Black Stain
Amy wrote this post. She is the designer and owner of FormFire Glassworks, where she creates modern lampwork glass beads and jewelry, and by day designs custom homes for a small firm in Southern California. You can follow her twitter @formfireglass.
With all the hoopla about the arrival of the new iPhones, I started thinking about the constant use of tech in our homes. Be it a smartphone, a tablet, a laptop or a desktop computer, we are rarely without some type of internet or computer access. But have you taken a look at many interior shots? How often do you see one of those items, especially in a carefully staged photo? I don't know about you, but if all of my family is home, in our family room there might be 4 phones, 2 iPads, 3 laptops and a desktop computer down the hall. Thank goodness my sofa has wide flat arms! I'm longing for good ways to handle having all that equipment around the house without it looking like an electronic dumpsite.
One person I know used to keep her iPad in a shelving unit, plugged in and running a slideshow, so it became a photo frame. Another keeps hers on a stand in the kitchen. I tend to carry mine around from place to place, and it always ends up on a counter, table or sofa arm. One of our laptops stays on the ottoman all day long, while I keep mine inside a box on a mid-height shelf when not in use. There are lots of great options for desktop computers and laptops if you have a designated workspace. Any small table will really do. Sometimes the dining room table end becomes the default computer work area. While I was designing a house last week, the idea of a charging area came up. But that assumes you're willing to park all your handheld devices away for a while. The nightstand that used to house a couple of books and a carafe of water is now comprised of cords and devices that recharge as we sleep.
(above) Corner Desk
Dining Table Desktop + Dedicated Office
Do you have any inspiring ways to handle tech clutter?
Amy wrote this post. She is the designer and owner of FormFire Glassworks, where she creates modern lampwork glass beads and jewelry, and by day designs custom homes for a small firm in Southern California. You can follow her twitter @formfireglass.


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By LARRY GOFFINET
Sports Editor
TELL CITY—Tell City sophomore Emma Kohnert was named to the All-PAC volleyball team in voting by conference coaches last week.
Kohnert, a 5-foot-11 sopohomore, led the Marksmen in kills with 308, in hitting percentage at .208, in kill percentage with 38.5 percent of her spikes going for kills, and in blocks with 40, including 31 solos.
She also made 84 digs.
By MIKE SPRAGUE
Sports Correspondent
LEOPOLD—Linton-Stockton controlled both sides of the line of scrimmage in defeating Perry Central 63-13 in the Class A football sectional semifinals Friday.
On Linton-Stockton's first play, Tyler Meurer took a pitchout and ran around the right side for 19 yards.
Three plays later he rushed for another 19 yards on another sweep. On nearly all their sweeps the Miners pulled at least one guard, who did a good job really getting into the Commodore defense.
TELL CITY—Tell City couldn't stop North Posey's power running game as the Vikings beat the Marksmen 42-21 in the Class 2A football sectional semifinals Friday.
Lance Inkenbrandt ran for 169 yards on 22 carries and scored four touchdowns for North Posey.
Fullback Dalton Rankin, a 6-foot, 230-pound sophomore, added 104 yards on 11 carries and scored one touchdown.
TELL CITY—Tell City's football team gets a chance to improve how much it has improved in recent weeks when it hosts North Posey for a semifinal sectional game Friday at 7 p.m.
After Tell City's first-round sectional win over Eastern Greene Friday, Tell City Coach Ronnie Robinson noted that both of the Marksmen's possible semifinal opponents "have beaten us in the regular season and I think that's a motivating factor to our kids to prove that we have gotten better."
LEOPOLD—Perry Central and Linton-Stockton will meet in their Class A football sectional for the fifth consecutive year Friday at 7 p.m., but both will sport slightly different looks this year.
Both graduated quite a few starters last year and 9-1 Linton is "a little bit more run-oriented" this year, Perry Central Coach Greg Gibson said Monday. "They probably run 60 percent of the time."
NASHVILLE—Tell City's team and the Simpson twins just missed qualifying for the boys state cross country meet with their performances in the Brown County semistate Saturday.
The top six teams in the 20-team semistate and the top 10 individuals not on those teams qualified for state.
Tell City finished seventh with 212 points, just nine behind sixth-place Terre Haute North.
LEOPOLD—Grace James' serving in the third game and Jordan Sprinkle's spiking in the fourth game propelled Perry Central past Linton-Stockon 23-25, 25-10, 25-20, 25-16 in the Class 2A volleyball regional Tuesday.
The 27-9 Commodores will play Indianapolis Ritter, ranked No. 4 in the state, in the first match of the Forest Park semistate Saturday at 10 a.m.
That will be followed by No. 1 Providence taking on unranked Union County at approximately noon.
Tell City and Perry Central have played some exciting regular-season games in a variety of sports through the years, which led to intense fan interest in a possible rematch in the sectional.
That's never been possible in football, though, because the two county schools are in different classes in that sport.
And it now appears that will remain the case next year, though just barely.
LYNNVILLE—Wood Memorial used its superior height to outspike and out-block Cannelton for a 25-7, 25-6, 25-8 win in a Class A volleyball sectional first-round match Thursday.
FERDINAND—Jordan Sprinkle made 17 kills and three blocks to lead Perry Central past North Posey 25-18, 25-18, 19-25, 25-17 in the Forest Park volleyball sectional semifinals Thursday.
The 25-9 Commodores were scheduled to meet 23-9 Mater Dei in the championship match Saturday.
Sprinkle was aggressive from the start of Thursday's match, making a kill for the Commodores' first point and adding two other powerful kills as they built their lead to 5-2.
Copyright © 2014
The Perry County News is your source for local news, sports, events, and information in Perry County, Indiana, and the surrounding area.


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Kukla's Korner Hockey
Islanders Need To Attack
by Paul on 04/13/07 at 10:28 AM ET
Comments (0)
from Joe Gergen at Newsday,
Certainly, the mind-set will have to change tomorrow night if the Islanders hope to tie the series.
"We might have been doing too much watching and not enough attacking," said defenseman Sean Hill. "It's nice to be close, but we were in position to steal that game. With the amount of offense we had, we have to take some solace in that."
For a team whose mantra in the final week was "desperate times call for desperate measures," perhaps the situation wasn't desperate enough.
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Top-notch tools for your software project manager toolbox
With the numerous tools available for project managers how can you be sure you've selected good ones? A tenured project manager points out good tools and resources in this expert response.
What are the pros and cons of centralizing a QA or software test team?
Is it better to centralize a test team or have testers paired organizationally with developers? There can be advantages to either approach. This expert response examines some considerations and an ...
Who determines the appropriate severity or priority for a defect?
There are often differences of opinion on the definition of severity or priority of a defect. The bottom line is determining when and if the defect will be fixed. Factors that need to be considered...
Variants between software quality assurance and software testing
There is a real gray area surrounding the differences between software quality assurance and software testing. Despite some overlap, they are really very different. In this expert response you will...
How do I create a test case based on requirements documents for user acceptance testing?
Creating user acceptance tests out of basic software requirements documents can be a daunting task. Expert Mike Kelly points out logical approaches testers could try in this tip.
What to look for in future renditions of Web 2.0 application security
This is an software expert's perspective on future Web 2.0 applications, security issues and expected problems. Prepare for future application difficulties by mastering solutions current ones says ...
Application performance testing across company networks
Software expert Mike Kelly gives insight into how to test applications across distributed networks and companies; how to properly setup test environments and accounting for various test models.
Resolving issues in baseline, load and stress testing
A software testing expert tackles root causes for application testing failures specifically in the realm of load, stress and baseline testing.
How to get development, QA, security and compliance teams to play nice
One of the great struggles in software development is getting teams to work cooperatively. Application security expert Kevin Beaver offers advice in this expert response.
Functional vs non-functional requirements, what is the difference?
Robin Goldsmith takes another stab at this question of functional vs non-functional requirements in this expert response. According to Goldsmith the difference lies in the applications need and wha...
Is SQL injection really the guilty party in software application vulnerabilities?
SQL injection is thought to be a major cause of Web vulnerabilities in software applications. Vulnerability scanners have made big business out of what security expert Kevin Beaver says are relativ...
Which requirements have the greatest effect on quality in software development?
Requirements metrics can be easy to define, difficult track results. Expert Robin Goldsmith exaimines the requirements phase of SDLC and determines where quality can be improved.
How to write an SRS document for three different databases
Beating software's cross-site scripting, authentication problems
Web security expert explains where security efforts are best placed. By checking for cross-site scripting and authentication mechanism weaknesses you can eliminate problems in your application.
How to write a Software Requirements Specification (SRS) document
Knowing how to write requirements documentation is crucial when developing and tracking the completion of software. Expert Robin Goldsmith goes over how to write SRS documents and how to distinguis...
How to approach JUnit for unit testing
JUnit is a useful tool for those conducting unit tests. Expert Mike Kelly explains how to begin using JUnit and recommends resources for those new to unit testing.
Put a stop to software espionage by watermarking source code
Having software code replicated or stolen is a major cause for concern in the industry, fortunately there are measures you can take to protect your software source code.
Data warehouse/BI performance testing tool recommendations
Expert selects preferred performance testing tools for data warehouse/BI software testing needs.
How to test usability for a positive user experience
Expert advises on finalizing usability testing by showing how to achieve a quality user experience, proper performance and desired effects.
What is the best approach to generating a positive user experience?
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Publications (568)1417.95 Total impact
Article: Combination therapy of hypertension in the elderly: a subgroup analysis of the Combination of OLMesartan and a calcium channel blocker or diuretic in Japanese elderly hypertensive patients trial.[Show abstract] [Hide abstract]
ABSTRACT: Combination of OLMesartan and a calcium channel blocker or a diuretic in Japanese elderly hypertensive patients (COLM) trial demonstrated that olmesartan combinations with a CCB or diuretic have similar effects on reducing cardiovascular risk in elderly hypertensive patients. However, the safety profiles suggest that olmesartan combined with CCB may be preferable to olmesartan combined with diuretic. In this subgroup analysis, we further evaluated the effects and safety of these combinations in elderly (65-74 years old (y.o.)) and very elderly (75-84 y.o.) hypertensive patients. In the COLM trial, 5141 patients (2918 elderly and 2223 very elderly) were randomly assigned to receive olmesartan-based therapy with either CCB or diuretic. The hazard ratios and 95% confidence intervals, respectively, in the elderly age group and in the very elderly group were: 1.04 (0.72-1.50; olmesartan plus CCB vs. olmesartan plus diuretic, P=0.85) and 0.71 (0.51-0.99, P=0.045) for the primary composite end point, and 1.07 (0.67-1.72, P=0.77) and 0.64 (0.42-0.98, P=0.036) for the composite of hard end points. The hazard ratios for stroke (fatal and non-fatal) were 1.48 (0.88-2.48; olmesartan plus CCB vs. olmesartan plus diuretic, P=0.13) and 0.63 (0.39-1.02, P=0.059) (interaction-P=0.019). Withdrawal rates from the trial, withdrawal due to serious adverse event and the incidence of any adverse event were higher in the olmesartan plus diuretic group than in the olmesartan plus CCB group in both age groups. In conclusion, angiotensin receptor blocker (ARB) and CCB combination may be preferable to an ARB and diuretic combination in the very elderly hypertensive patients for the reduction of cardiovascular risk, particularly for the reduction in stroke risk.Hypertension Research advance online publication, 25 September 2014; doi:10.1038/hr.2014.144.Hypertension research : official journal of the Japanese Society of Hypertension. 09/2014;
Article: Comparison of olmesartan combined with a calcium channel blocker or a diuretic in elderly hypertensive patients (COLM Study): safety and tolerability.[Show abstract] [Hide abstract]
ABSTRACT: The cardiovascular effects of combined therapy with the angiotensin receptor blocker (olmesartan) and a dihydropyridine calcium channel blocker (CCB) or a diuretic were compared in high-risk elderly Japanese hypertensive patients by performing a randomized, open label, blinded-endpoint study of morbidity and mortality (the COLM study). Here we report the results obtained with respect to safety and tolerability. High-risk hypertensive patients aged 65-84 years were enrolled and were randomized to receive olmesartan combined with either a CCB (amlodipine or azelnidipine) or a low-dose diuretic for at least 3 years. The primary endpoint was a composite of fatal and non fatal cardiovascular events, whereas adverse events (AEs) and the percentage of patients who discontinued the allocated treatment were evaluated as secondary endpoints. A total of 5141 patients were randomized. Both combination regimens achieved a similar reduction of cardiovascular morbidity and mortality. The incidences of AEs, serious AEs, drug-related serious AEs and discontinuation due to serious AEs were lower in the olmesartan plus CCB group than in the olmesartan plus diuretic group. Serum levels of uric acid and creatinine were significantly higher in the olmesartan plus diuretic group than in the olmesartan plus CCB group. Olmesartan combined with a CCB was significantly superior to olmesartan plus a diuretic with regard to the frequency of AEs and discontinuation of treatment.Hypertension Research advance online publication, 25 September 2014; doi:10.1038/hr.2014.141.Hypertension research : official journal of the Japanese Society of Hypertension. 09/2014;
Article: Elevation of circulating fatty acid-binding protein 4 is independently associated with left ventricular diastolic dysfunction in a general population.[Show abstract] [Hide abstract]
ABSTRACT: Background Fatty acid-binding protein 4 (FABP4) is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, hypertension, and atherosclerosis. However, little is known about role of FABP4 in cardiac function.Methods From the database of the Tanno-Sobetsu Study, data for 190 subjects (male/female: 82/108) who were not treated with any medication and underwent echocardiography in 2011 or 2012 were retrieved for analyses of relationships between serum FABP4 concentration, metabolic markers and parameters of echocardiography.ResultsSerum FABP4 level was positively correlated with age, body mass index (BMI), blood pressure (BP), LDL cholesterol, HOMA-R and mean left ventricular (LV) wall thickness (LVWT, males: r¿=¿0.315, females: r¿=¿0.401, p¿<¿0.01) and was negatively correlated with HDL cholesterol, estimated glomerular filtration rate (eGFR) and peak myocardial velocity during early diastole (e¿; males: r¿=¿¿0.434, females: r¿=¿¿0.353, p¿<¿0.01), an index of LV diastolic function. However, no significant correlation was found between FABP4 level and LV end-diastolic dimension, LV ejection fraction or LV mass index. There were significant correlations of e¿ with age, BMI, BP, eGFR, brain natriuretic peptide (BNP), FABP4, metabolic markers and LVWT. Multivariate regression analysis adjusted by HOMA-R, BMI, eGFR, BNP or LVWT in addition to age, gender and BP revealed that serum FABP4 concentration was independently correlated with e¿.Conclusions Elevation of circulating FABP4 may contribute to LV diastolic dysfunction in a general population.Cardiovascular Diabetology 08/2014; 13(1):126. · 4.21 Impact Factor
Article: Combinations of olmesartan and a calcium channel blocker or a diuretic in elderly hypertensive patients: a randomized, controlled trial1.[Show abstract] [Hide abstract]
ABSTRACT: The aim of the present study was to compare the cardiovascular effects of olmesartan, an angiotensin II receptor blocker, combined with a calcium channel blocker (CCB) or a diuretic, in a prospective, randomized, open-label, blinded endpoint trial.Journal of hypertension. 07/2014;
Dataset: HOMED-BP-GENE論文
Article: Urinary Angiotensin-Converting Enzyme 2 in Hypertensive Patients May Be Increased by Olmesartan, an Angiotensin II Receptor Blocker.[Show abstract] [Hide abstract]
ABSTRACT: Angiotensin-converting enzyme 2 (ACE2) is highly expressed in the kidney and converts angiotensin (Ang) II to Ang-(1-7), a renoprotective peptide. Urinary ACE2 has been shown to be elevated in patients with chronic kidney disease. However, the effects of antihypertensive agents on urinary ACE2 remain unclear.American Journal of Hypertension 05/2014; · 3.67 Impact Factor
Article: A randomised controlled trial for the evaluation of risk for type 2 diabetes in hypertensive patients receiving thiazide diuretics: Diuretics In the Management of Essential hypertension (DIME) study.[Show abstract] [Hide abstract]
ABSTRACT: Thiazide diuretics are one of the first choice antihypertensives but not optimally utilised because of concerns regarding their adverse effects on glucose metabolism. The Diuretics In the Management of Essential hypertension (DIME) study was designed, for the first time, to assess the risk for type 2 diabetes mellitus in patients with essential hypertension during antihypertensive treatment with low-dose thiazide diuretics compared to those not treated with diuretics.BMJ Open 01/2014; 4(7):e004576. · 1.58 Impact Factor
Article: Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study.[Show abstract] [Hide abstract]
ABSTRACT: Background: Patients with mild-to-moderate essential hypertension in the HOMED-BP trial were randomly allocated to first-line treatment with a calcium channel blocker (CCB), angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB). Methods: We recruited 265 (93 for CCB, 71 for ACEI and 101 for ARB) patients who completed the genomic study. Home blood pressure was measured for 5 days off-treatment before randomization and for 5 days after 2-4 weeks of randomized drug treatment. Genotyping was performed by 500K DNA microarray chips. The blood pressure responses to the three drugs were analyzed separately as a quantitative trait. For replication of SNPs with p < 10(-4), we used the multicenter GEANE study, in which patients were randomized to valsartan or amlodipine. Results: SNPs in PICALM, TANC2, NUMA1 and APCDD1 were found to be associated with CCB responses and those in ABCC9 and YIPF1 were found to be associated with ARB response with replication. Conclusion: Our approach, the first based on high-fidelity phenotyping by home blood pressure measurement, might be a step in moving towards the personalized treatment of hypertension. Original submitted 29 April 2013; Revision submitted 14 August 2013.Pharmacogenomics 11/2013; 14(14):1709-21. · 3.86 Impact Factor
Article: Comparative effects of telmisartan and valsartan as add-on agents for hypertensive patients with morning blood pressure insufficiently controlled by amlodipine monotherapy.[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to determine the efficacies of valsartan and telmisartan as add-on agents for the control of morning blood pressure (BP) in patients already on amlodipine monotherapy. A total of 414 hypertensive patients were prospectively enrolled in a 4-week run-in period when they were treated with amlodipine (5 mg/day), and home BP was measured in the morning and evening. Patients with home systolic BP (SBP) being 135-159 mm Hg in the morning at the end of the run-in period were randomized to additional treatment with valsartan (80 mg/day) or with telmisartan (40 mg/day) for 8 weeks. The primary endpoint was the change in morning home BP, and secondary endpoints included variability of morning home BP. Of the 282 patients randomized, 262 patients (n=131, in each treatment) completed the protocols. Demographic parameters and baseline morning SBP/diastolic BP (DBP) (146.3±7.1/84.8±9.3 vs. 146.0±7.1/84.2±9.1 mm Hg) were comparable in the valsartan group and telmisartan group, and changes in SBP/DBP after 8-week treatment were not significantly different between the two groups (-7.4±10.6/-3.9±6.1 vs. -8.3±9.9/-5.0±5.9 mm Hg). Valsartan significantly increased individual standard deviation and variation coefficient of morning SBP, but telmisartan did not change either of these indices of SBP variation. In subgroups with baseline SBP being above the median (145.2 mm Hg), change in DBP was significantly larger by telmisartan than by valsartan (-6.3±5.6 vs. -3.9±6.7 mm Hg, P<0.05). These results suggest that telmisartan is more useful than valsartan as an add-on agent for reducing the level and variability of morning BP in patients on amlodipine monotherapy.Hypertension Research advance online publication, 10 October 2013; doi:10.1038/hr.2013.141.Hypertension Research 10/2013; · 2.79 Impact Factor
Article: Nifedipine controlled-release 40 mg b.i.d. in Japanese patients with essential hypertension who responded insufficiently to nifedipine controlled-release 40 mg q.d.: a phase III, randomized, double-blind and parallel-group study.[Show abstract] [Hide abstract]
ABSTRACT: This phase III, multicenter, randomized, double-blind, parallel-group study compared the efficacy and safety of nifedipine controlled-release (CR) 40 mg twice daily (b.i.d.) and once daily (q.d.) in 325 Japanese patients with essential hypertension uncontrolled with nifedipine CR 40 mg q.d. (ClinicalTrials.gov record: NCT01287260). The primary endpoint was the change from baseline in trough seated diastolic blood pressure (DBP) after 8 weeks. Nifedipine CR 40 mg b.i.d. showed significantly greater reductions in trough seated DBP (-7.7±0.6 mm Hg vs. -3.6±0.6 mm Hg) and trough seated systolic blood pressure (BP) (-11.1±0.9 mm Hg vs. -3.7±0.9 mm Hg) after 8 weeks of treatment compared with nifedipine CR 40 mg q.d. (both P<0.0001). At week 8, BP target achievement and responder rates were higher with nifedipine CR 40 mg b.i.d. (21.5% and 42.4% vs. 10.3% and 19.5%, respectively). Adverse events considered related to the study drug were reported in 9.0 and 9.7% of patients receiving nifedipine CR 40 mg b.i.d. and q.d., respectively. The frequency of drug-related adverse events commonly reported with nifedipine CR (headache, hot flush, palpitations, peripheral edema, hypotension, dizziness, tachycardia) was low and the results were similar between the treatment groups. In conclusion, a higher dose of nifedipine CR was associated with greater efficacy and a safety profile similar to that of the currently approved dose (40 mg q.d.) in Japanese patients with essential hypertension, and it may offer a valuable treatment choice for patients who do not achieve target BP levels with standard treatment.Hypertension Research advance online publication, 15 August 2013; doi:10.1038/hr.2013.80.Hypertension Research 08/2013; · 2.79 Impact Factor
Article: Combination therapy for hypertension in patients with CKD: a subanalysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events trial.[Show abstract] [Hide abstract]
ABSTRACT: The Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) trial was a multicenter, randomized, three-arm comparative study (N=3293) undertaken to determine the optimal combination therapy, based on the occurrence of cardiovascular events in patients treated with an angiotensin II receptor blocker (ARB), a β-blocker (BB) or a thiazide diuretic (TD) in addition to the calcium antagonist benidipine as baseline medication. This subanalysis was conducted to compare the efficacy of three combination therapies in a subset of 834 patients with chronic kidney disease (CKD) (287 patients treated with benidpine-ARB, 283 patients treated with benidipine-BB and 264 patients treated with benidipine-TD). The incidence of composite cardiovascular events as the primary end point did not differ among these three groups. The incidence of hard end points and cerebrovascular events among these groups did not differ either, although the incidence among all patients in the COPE trial was lower in the benidipine-TD group than in the benidipine-BB group. The incidence of new-onset diabetes mellitus was higher in the benidipine-TD group than in the benidipine-ARB group among patients with CKD. The estimated glomerular filtration rate (eGFR) was maintained even after 12 months of treatment in patients with a baseline eGFR <60 ml min(-1) per 1.73 m(2) regardless of the treatment group, although the eGFR decreased over time in all patients in the three groups. In conclusion, in patients with CKD, all of the tested combination therapies demonstrated comparable efficacy in terms of prevention of cardiovascular events as well as maintenance of eGFR.Hypertension Research advance online publication, 18 July 2013; doi:10.1038/hr.2013.63.Hypertension Research 07/2013; · 2.79 Impact Factor
Article: Resveratrol Improves Cardiomyopathy in Dystrophin-deficient Mice through SIRT1-mediated modulation of p300.[Show abstract] [Hide abstract]
ABSTRACT: Cardiomyopathy is the main cause of death in Duchenne muscular dystrophy. Here we show that oral administration of resveratrol, which leads to activation of an NAD+-dependent protein deacetylase SIRT1, suppresses cardiac hypertrophy and fibrosis, and restores cardiac diastolic function in dystrophin-deficient mdx mice. The pro-hypertrophic co-activator p300 protein but not p300 mRNA was upregulated in the mdx heart and resveratrol administration downregulated the p300 protein level. In cultured cardiomyocytes, cardiomyocyte hypertrophy induced by an α1 agonist phenylephrine was inhibited by the overexpression of SIRT1 as well as resveratrol, both of which downregulated p300 protein level but not p300 mRNA level. In addition, activation of atrial natriuretic peptide promoter by p300 was inhibited by SIRT1. We found that SIRT1 induced p300 downregulation via the ubiquitin/proteasome pathway by deacetylation of lysine residues for ubiquitination. These findings indicate the pathological significance of p300 upregulation in the dystrophic heart and that SIRT1 activation has the therapeutic potential for dystrophic cardiomyopathy.Journal of Biological Chemistry 01/2013; · 4.65 Impact Factor
- Nippon rinsho. Japanese journal of clinical medicine 11/2012; 70 Suppl 8:593-6.
Article: Elevation of fatty acid-binding protein 4 is predisposed by family history of hypertension and contributes to blood pressure elevation.[Show abstract] [Hide abstract]
ABSTRACT: Background Fatty acid-binding protein 4 (FABP4/A-FABP/aP2), a lipid chaperone, is expressed in both adipocytes and macrophages. Recent studies have shown secretion of FABP4 from adipocytes and association of elevated serum FABP4 level with obesity, insulin resistance, and atherosclerosis. However, little is known about the role of FABP4 in essential hypertension.Methods We first examined serum FABP4 concentrations in 18 normotensives (NT) and 30 nontreated essential hypertensives (EHT). The EHT were divided into 18 insulin-sensitive EHT (EHT-S) and 12 insulin-resistant EHT (EHT-R) based on their insulin-sensitivity index, the M value, determined by the hyperinsulinemic-euglycemic clamp technique. In the second study, we determined FABP4 levels in 30 young NT men with or without a family history of hypertension (FH(+) and FH(-), respectively; n = 15 each).ResultsSerum FABP4 level was significantly higher in the EHT-R than in the NT, whereas elevation of FABP4 level in the EHT-S was not statistically significant. FABP4 level was positively correlated with age, body mass index (BMI), blood pressure, and triglycerides and negatively correlated with the M value. FABP4 level was an independent predictor of mean arterial pressure after adjustment of age, gender, and adiposity. The FH(+) group had a significantly lower level of M value and higher level of FABP4 than did the FH(-) group, and FABP4 concentration was an independent determinant of the M value.ConclusionsFABP4 contributes to blood pressure elevation and atherogenic metabolic phenotype in hypertensives, and the elevation of FABP4 is predisposed by a family history of hypertension.American Journal of Hypertension 2012; doi:10.1038/ajh.2012.88.American Journal of Hypertension 06/2012; 25(10):1124-30. · 3.67 Impact Factor
Article: Impact of serum uric acid on renal function and cardiovascular events in hypertensive patients treated with losartan.[Show abstract] [Hide abstract]
ABSTRACT: High serum uric acid level (SUA) and chronic kidney disease (CKD) are risk factors for cardiovascular events (CVEs). However, their interactions as cardiovascular risk factors remain unknown. This subanalysis of the Japan Hypertension Evaluation with Angiotensin II Antagonist Losartan Therapy (J-HEALTH) study included 7629 patients, in whom the serum creatinine level was measured at least twice. The study examined the impact of hyperuricemia (SUA ≥7 mg dl(-1)) on CVE according to the level of renal dysfunction and whether early changes in SUA predicted future glomerular filtration rates (GFRs). The mean follow-up period was 3.1 years. The patients were divided into three groups according to the baseline estimated GFR (eGFR): groups A, B and C with eGFR <45, 45-59 and ≥60 ml min(-1) per 1.73 m(2), respectively. eGFR increased from 38.1 to 57.6, from 52.8 to 67.5 and from 74.7 to 80.7 ml min(-1) per 1.73 m(2) in groups A, B and C, respectively. In non-hyperuricemic patients, the CVE rate was 10.83, 4.98 and 4.21/1000 person-years in groups A, B and C, respectively, while in hyperuricemic patients, the corresponding values were 14.18, 17.02 and 5.93. Thus, hyperuricemia increased the risk of CVE only in group B (relative risk (RR) 3.43 (95% confidence interval (CI) 1.55 to 7.60); P<0.002). The final change in the eGFR was negatively correlated with the change in SUA from baseline to year 1 (P<0.001). CVEs were more frequent in those with a decrease in eGFR. Hyperuricemia may be a major determinant of increased cardiovascular risk in CKD stage 3A, and SUA may be involved in the progression of CKD. Changes in the GFR influence the rate of CVE.Hypertension Research 05/2012; 35(8):867-73. · 2.79 Impact Factor
Article: Two- and three-dimensional assessments of myocardial perfusion and function by using technetium-99m sestamibi gated SPECT with a combination of count- and image-based techniques.[Show abstract] [Hide abstract]
ABSTRACT: Although the myocardial gated single photon emission computed tomography (SPECT) technique makes it possible to assess concurrent myocardial perfusion and function, quantitative methods for analyzing and displaying gated SPECT data in 2- and 3-dimensional presentations for regional and global cardiac assessment have not been established. We have developed an automated quantitative method for assessing perfusion and function by means of technetium-99m sestamibi gated SPECT with a computerized technique combining count-based and image-based methods. We have examined its validity in 91 patients by comparing its results with those of conventional techniques: contrast left ventriculography and radionuclide angiocardiography. In addition to color-scale displays of regional function, simultaneous 3-dimensional presentations of regional wall motion and perfusion have been produced. High reproducibility of gated SPECT analysis with this algorithm was demonstrated; interoperator errors (%CV) were 2.6% to 5.5%, and good intraobserver reproducibility was confirmed by means of high correlation coefficients (0.954 to 0.989). Left ventricular volumes assessed by means of contrast left ventriculography and by means of the gated SPECT technique showed significant correlations (left ventricular end-diastolic volume, y = 1.01x - 9.7, r = 0.845, P<.001, standard errors of the estimate [SEE] = 14 mL; left ventricular end-systolic volume, y = 1.03x - 1.4, r = 0.902, P<.001, SEE = 6 mL). Left ventricular ejection fraction determined by means of gated SPECT with the new algorithm closely correlated with that determined by means of radionuclide ventriculography (y = 1.05x - 0.6, r = 0.891, P<.001, SEE = 3 %). These parameters quantified by means of the present method correlated closely with those derived from the QGS program (r = 0.926 to 0.987). In comparison with conventional techniques, myocardial gated SPECT with automated quantitative analysis provides accurate and reproducible data for global and regional function. Quantitative concurrent assessment of myocardial perfusion and function by using 2-and 3-dimensional representations appears to be superior to other modalities and to contribute to nuclear cardiology practice.Journal of Nuclear Cardiology 04/2012; 7(6):623-32. · 2.85 Impact Factor
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ABSTRACT: A new understanding of the genetic basis of coronary artery disease (CAD) has recently emerged from genome-wide association (GWA) studies of common single-nucleotide polymorphisms (SNPs), thus far performed mostly in European-descent populations. To identify novel susceptibility gene variants for CAD and confirm those previously identified mostly in populations of European descent, a multistage GWA study was performed in the Japanese. In the discovery phase, we first genotyped 806 cases and 1337 controls with 451 382 SNP markers and subsequently assessed 34 selected SNPs with direct genotyping (541 additional cases) and in silico comparison (964 healthy controls). In the replication phase, involving 3052 cases and 6335 controls, 12 SNPs were tested; CAD association was replicated and/or verified for 4 (of 12) SNPs from 3 loci: near BRAP and ALDH2 on 12q24 (P=1.6 × 10(-34)), HLA-DQB1 on 6p21 (P=4.7 × 10(-7)), and CDKN2A/B on 9p21 (P=6.1 × 10(-16)). On 12q24, we identified the strongest association signal with the strength of association substantially pronounced for a subgroup of myocardial infarction cases (P=1.4 × 10(-40)). On 6p21, an HLA allele, DQB1(*)0604, could show one of the most prominent association signals in an ∼8-Mb interval that encompasses the LTA gene, where an association with myocardial infarction had been reported in another Japanese study. CAD association was also identified at CDKN2A/B, as previously reported in different populations of European descent and Asians. Thus, three loci confirmed in the Japanese GWA study highlight the likely presence of risk alleles with two types of genetic effects - population specific and common - on susceptibility to CAD.European journal of human genetics: EJHG 03/2012; 20(3):333-40. · 3.56 Impact Factor
Article: Combination therapy for hypertension in the elderly: a sub-analysis of the Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) Trial.[Show abstract] [Hide abstract]
ABSTRACT: The Combination Therapy of Hypertension to Prevent Cardiovascular Events (COPE) trial demonstrated that the calcium-channel blocker benidipine-based combination therapies with an angiotensin-receptor blocker (ARB), a β-blocker, or a thiazide diuretic (thiazide) were similarly effective in preventing cardiovascular events and achieving the target blood pressure (BP; <140/90 mm Hg). We further evaluated the efficacy and safety of these combination therapies in older (65 years) and younger (<65 years) hypertensive patients. In this sub-analysis of the COPE trial 3293 patients (153365 years old and 1760 <65 years old) were randomly assigned to receive benidipine-based therapy with an ARB, a β-blocker or a thiazide. In each group, the average BP did not differ among the three treatment groups. The incidence of the primary cardiovascular composite end point in the older group was higher than in the younger group (12.7 vs. 8.3 per 1000 person-years, P=0.023). The primary composite cardiovascular end point, achievement (%) of target BP, and cardiovascular hard composite end points were similar among the three treatment groups. However, the hazard ratios and 95% confidence intervals in older patients were 2.74 (1.08-6.96; β-blocker vs. thiazide, P=0.022) for fatal and non-fatal stroke, and 2.47 (1.03-5.91; β-blocker vs. ARB, P=0.043) for new-onset diabetes. Thus, benidipine combined with an ARB, a β-blocker, or a thiazide was similarly effective in preventing cardiovascular events and achieving the target BP in both older and younger hypertensive patients. Further studies will be necessary to evaluate the usefulness of benidipine combined with a β-blocker in terms of the incidence of stroke and new-onset diabetes in older patients.Hypertension Research 01/2012; 35(4):441-8. · 2.79 Impact Factor
Article: Fusion of bone marrow-derived cells with renal tubules contributes to renal dysfunction in diabetic nephropathy.[Show abstract] [Hide abstract]
ABSTRACT: Although diabetic nephropathy (DN) is a major cause of end-stage renal disease, the mechanism of dysfunction has not yet been clarified. We previously reported that in diabetes proinsulin-producing bone marrow-derived cells (BMDCs) fuse with hepatocytes and neurons. Fusion cells are polyploidy and produce tumor necrosis factor (TNF)-α, ultimately causing diabetic complications. In this study, we assessed whether the same mechanism is involved in DN. We performed bone marrow transplantation from male GFP-Tg mice to female C57BL/6J mice and produced diabetes by streptozotocin (STZ) or a high-fat diet. In diabetic kidneys, massive infiltration of BMDCs and tubulointerstitial injury were prominent. BMDCs and damaged tubular epithelial cells were positively stained with proinsulin and TNF-α. Cell fusion between BMDCs and renal tubules was confirmed by the presence of Y chromosome. Of tubular epithelial cells, 15.4% contain Y chromosomes in STZ-diabetic mice, 8.6% in HFD-diabetic mice, but only 1.5% in nondiabetic mice. Fusion cells primarily expressed TNF-α and caspase-3 in diabetic kidney. These in vivo findings were confirmed by in vitro coculture experiments between isolated renal tubular cells and BMDCs. It was concluded that cell fusion between BMDCs and renal tubular epithelial cells plays a crucial role in DN.The FASEB Journal 12/2011; 26(4):1559-68. · 5.70 Impact Factor
Article: [Association of obesity and other cardiovascular risk factors with stroke the Japan Arteriosclerosis Longitudinal Study--Existing Cohorts Combined (JALS-ECC)].[Show abstract] [Hide abstract]
ABSTRACT: To assess the relationship between metabolic risk factors and the incidence of stroke stratified by obesity, by conducting a meta-analysis using individual participant data from prospective cohort studies. A total of 19,173 individuals from 10 cohort studies participated at baseline after 1985. Metabolic risk factors were defined using the established criteria in Japan. Participants were subdivided into five categories according to the levels of risk factors and obesity defined by BMI > or = 25 (kg/m2). Multivariate adjusted hazard ratios (HRs) for the incidence of stroke and the population attributable risk (PAR) were estimated by Poisson regression. During an average 7.1-year follow-up period, 374 stroke events occurred. Hypertension was highest among the risk factors not concerned with BMI stratification. The HR for stroke was 2.48 (95% CI: 1.75-3.5) for BMI < 25 with 1 other risk factor and 3.75 (2.58-5.45) with 2 or more, 2.38 while it was (1.58-3.59) for BMI > or = 25 with 0 or 1 factor and 3.26 (2.11-5.02) with 2 or more. The HR was significantly elevated in all categories with one or more risk factors. The PAR was highest in the category of BMI < 25 with 1 risk factor (23.3%) and second highest in the category of BMI < 25 with 2 or more. The respective PARs for BMI > or = 25 with 0 or 1 and 2 or more risk factors were 8.1% and 8.0%. Similar results were found from the analyses of different stroke subtypes. The HR was found to be significantly elevated with the number of risk factors both with and without obesity. The attributable risk for stroke was larger in the non-obese group. Therefore, public health intervention based only on obesity may miss many of those at high risk of stroke so the focus should not only be on obesity but also cardiovascular risk factors.[Nippon kōshū eisei zasshi] Japanese journal of public health 12/2011; 58(12):1007-15.
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Created: 07/17/2014 11:28 AM
By: KOB.com Web Staff
Doña Ana County deputies say a mother beat her 17-year-old daughter when she came out as gay.
Magdo Haro, 40, was taken into custody Tuesday after her daughter told investigators her mother beat her repeatedly with a shoe after the girl confessed that she was gay.
According to statements made to investigators, the girl was told she was "not to wear boy clothes anymore, only girl clothes," and that she would have to start attending church with her grandmother.
The girl also said she was forced to undress in front of her mother to "show her she was a woman, and not a man." The girl reported that her mother then demanded that she perform sex acts on herself, so the girl complied out of fear that her mother was going to sexually assault her.
Haro was arrested late Tuesday afternoon on charges of criminal sexual penetration and child abuse. She was transported to the Doña Ana County Detention Center where she was released three hours later on a $25,000 secured bond.
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Other Sports
MU proves point with high scores
For the first 24 years of its gymnastics program, Missouri never scored at or above 197 points. The Tigers have done it three times in one season.
Missouri scored 197.125 at the Mizzou Invitational on Saturday, defeating Northern Illinois (192.875), Illinois State (191.750) and Centenary (191.400) at this season's final meet at Hearnes Center.
In the presence of Greatness
As a numbers game, basketball traditionally favors the team with more points, more rebounds and more precise passes. Of course, having more superstars on the court at once doesn't hurt, either.
Since 1972, Hearnes Center has set the perfect stage for the best players in Missouri history, but it was clearly a better showcase for double-act talent.
Tigers' depth provides boost
Depth has given Missouri a seasoned flavor.
The Tigers are benefiting from tough competition for lineup spots, competition that allows coaches to rest key contributors without lowering scores, which increases team confidence.
Stars helped women's game grow
In the 30-year history of Missouri women's basketball, 159 players donned the Tigers' home white uniforms at Hearnes Center.
Condensing those players to a list of the five greatest players in Missouri history is no easy task, but those on the all-time Missouri team tout resumes that separate them from the rest.
Streaking Cougars seek AMC crown
Mike Davis, the Columbia College women's basketball coach, said his team usually builds momentum slowly and eventually wears down its opponent. His theory also applies to the Cougars' season.
The Cougars beat Hannibal-LaGrange 84-61 in the second round of the American Midwest Conference Tournament on Friday at The Arena of Southwell Complex.
Bolerjack too much for Chiefs in 1st half
SEDALIA – Jodi Bolerjack did more than lead Hickman to victory Saturday.
She outscored the other team in the first half.
Several women dominated play against Missouri
Some players just knew how to win on the road.
Opposing women's basketball teams have had little success at Hearnes Center, winning 102 of 382 games in Columbia. Although their teams might not have always won, five players have always found a way to hurt Missouri at Hearnes Center.
Tigers have fun in sweep
Erica Petersen didn't think she would play this weekend, let alone close out a pair of wins in a softball doubleheader.
Petersen, a freshman pitcher for Missouri, has been on antibiotics for the past week to treat strep throat.
Oklahoma hands Tigers tough loss
After Saturday's match against Oklahoma, Missouri tennis coach Blake Starkey said he knows why some coaches develop ulcers and lose their hair.
The Tigers lost 5-2 to the Sooners at Green Tennis Center in a Big 12 Conference match, but Oklahoma won two singles matches in third-set tiebreaks that could have swung the match to Missouri.
Cougars beat Hannibal-LaGrange at AMC tournament
Mike Davis, the Columbia College women's basketball coach, said his team usually builds momentum slowly and eventually wears down its opponent. His theory also applies to the Cougars' season.
The Cougars beat Hannibal-LaGrange 84-61 in the second round of the American Midwest Conference Tournament on Friday at The Arena of Southwell Complex.
Cougars outhustled in home loss
Great shooting and hustle have helped the Columbia College men's basketball team ascend to national prominence this season, but Missouri Baptist used the Cougars' successful formula against them Thursday night.
The Spartans beat the Cougars 84-73 and handed Columbia College its first loss at The Arena of Southwell Complex. The Cougars and Spartans are tied for the American Midwest Conference lead.
None better than Big 12
Missouri coach Brian Smith said he is confident his wrestling team can beat the best teams in the nation. To win the Big 12 Conference Tournament, it's going to have to.
Smith said he thinks this season's Big 12 Tournament could be the toughest to date. The five teams in the conference will meet Saturday at Iowa State's Hilton Coliseum.
Seniors have led Missouri into top 20
Four years ago, Missouri gymnastics was a weak program that had competed in one regional meet since 1994.
This season, behind a strong senior class entering its final home meet, the No. 18 Tigers are a threat to post a strong regional performance and could finish high enough to qualify for the national finals for the first time since 1981.
Hearnes' legacy beyond building
Gov. Warren Hearnes made many contributions to education, but the building Missouri athletics has called home for the past 32 years is his best-known contribution.
In 1966, Hearnes went to see Missouri play football at the University of Illinois. The trip changed Missouri athletics. After lunch with Illinois chancellor George Russell, who became Missouri's university president, they went to see Illinois' new basketball arena, Assembly Hall. Hearnes knew right away that it was what Missouri needed.
Miscues too costly for Tigers
LUBBOCK, Texas – Despite all of Missouri's maturation, Wednesday's game at Texas Tech, in some ways, resembled the losing pattern of late December.
In their 87-76 loss at the United Spirit Arena, the Tigers committed 16 turnovers. Those turnovers allowed Texas Tech to stay with the Tigers and eventually take control. The Red Raiders turned the Tigers' turnovers into 27 points.
Bolerjack driven to do better
Jodi Bolerjack wasn't 100 percent and it bugged her.
It was the 2003 Class 5 quarterfinals against Kickapoo. It was the biggest game she had played in since returning from anterior cruciate ligament injury on her left knee.
Tigers' backfield will have new look
Calling Marcus Woods quick is like calling Bill Gates rich.
Woods put on a show as one of the return men on a punt coverage drill during the Missouri football team's first spring practice Thursday at Dan Devine Pavilion.
Missouri fouls up chance for victory
LUBBOCK, Texas – Texas Tech didn't need any help getting more points, but Missouri gave it an assist anyway.
The Red Raiders benefited greatly from converting on 24-of-29 trips to the foul line in their 87-76 win Wednesday in the United Spirit Arena.
Tigers' defense falters in 2nd half
LUBBOCK, Texas — All it takes is a split-second lapse, a loss of focus on defense that allows the opponent to score.
All teams experience those mistakes, but rarely does one commit them consistently for more than nine minutes.
Johnson biggest of MU's big men
LUBBOCK, Texas — Before the season, Arthur Johnson made it a goal to become Missouri's best big man.
Johnson took another step to taking that title. After he grabbed eight rebounds at Texas Tech on Wednesday night, Johnson passed former MU great Doug Smith, a fellow Detroit native, for the school mark. Johnson has 1,554 rebounds, one more than Smith.


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Academic Pediatric Anesthesiologist being recruited to New Orleans
The department of Pediatric Anesthesiology and Pain Medicine at Cook Children's Hospital is seeking a pediatric anesthesiologist to join an existing staff of 27 pediatric anesthesiologists.
Director of Pediatric Anesthesia in Brooklyn!
Carle Physician Group is seeking to add two BE/BC Pediatric Anesthesiologists to join our group of 10 Anesthesiologists and 45 CRNAs.


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This holiday season, Chase is offering VIP lounges for United MileagePlus cardholders at two major US shopping malls, one in San Francisco, and the other in Short Hills, NJ. These lounges will be accessible to primary cardholders of any Chase United card (including the MileagePlus Explorer, the… Read More
Check out the week in travel contests and sweepstakes for your chance to win a wine trip to France, win thousands of Air France miles, see relax in Puerto Rico, eat your way through Palm Beach & tour London.
Win Thousands of Miles From Air France
Play the Mr. Miles game and have a chance to win… Read More
In a blow to American aviation manufacturer Boeing, Delta announced yesterday that from 2017 to 2019, the airline will replace its older Boeing 747-400s and 767-300ERs with 25 long-haul A350-900s and 25 medium-haul A330-900neos from European-owned Airbus, which feature Rolls Royce engines, and… Read More
You can view all posts in the Monthly Valuation Series here.
One of the questions I'm asked most often is "how much is a point or mile worth?" That question varies from person to person and depends on how well you can maximize a particular currency for your needs. Still, some points are worth… Read More


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Greedy consumption at heart of Seacoast exhibition
It's a sort of artistic take on the old adage, "You can't take it with you."
"Vanitas: The Meaningless and Futility of Conspicuous Consumption," the brainchild of local printmaker Shane P. Chick, features the work of more than 22 artists exploring a Flemish type of dark, symbolic work of art popular in the 17th century.
The showcase will open Friday, April 5, at 3S Artspace's temporary gallery space in the Store Gallery, 319 Vaughan St., Portsmouth.
Meaningless Things
"Still life was the predominant mode of communicating this paradox, of working your whole life to amass wealth only to die and have it become meaningless," said Chick of the Flemish idea of "vanitas."
Painters in the 1600s engaged in a running commentary on the wealth and power of the Dutch through their works, motivated by the thought that once at the top there was only one direction left to travel - downward. Riches would do no one service once a person was dead and buried, curators said.
"The themes that were explored were dark, depressing and full of skulls, overripe fruits, clocks and items of opulence in various states of decay," Chick said. "This is an idea that we feel is not only historical, but also poignant and contemporary.
"We, as a country, are in the depths of the consequences of becoming the richest most powerful entity on the planet," he said. "We either despair or compensate for those feelings of powerlessness with a fascination of the themes that were painted in the 17th-century Dutch. This show will have its dark spots of skulls and dead birds, as well as tongue-in-cheeks explorations of the rise to wealth."
In addition to Chick, participating artists, who have expressed their points of view through various mediums, including painting, photography, mixed media, wood-block prints and installation, include Wayne Atherton, Erin Bonneau, Shawn Burke, Courtney Chelo, Taintor Davis Child, Kenley Darling, Peter Flynn Donovan, Josh Dow, Lauren Dow, Aaron Drew, Kim Ferriera, Nick Filth, John Gayle, Carly Glovinski, Ali Goodwin, Jasmine Inglesmith, Jeanne McCartin, Kate Mochon, Sam Paolini, Dave Pettengill, Nathaniel Raymond, Meghan Samson, Lynn Szymanski and Jocelyn Toffic.
Their works, curators said, tie together to tell the story of the "meaningless pursuit of greedy consumption."
An opening reception will take place from 5 to 8 p.m. Friday and will be followed by a party and open-studios event on the second floor with live music and local food from 8 to 11 p.m. "Vanitas" will run through Sunday, April 28. Hours are Fridays from 11 a.m. to 6 p.m., Saturdays from 11 a.m. to 6 p.m., and Sundays from noon to 4 p.m. For more information, log onto 3sarts.org or facebook.com/3SArtspace.
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In the wake of a crushing defeat last week for the climate alarmism-promoting Australian Labor Party, which imposed the deeply unpopular and expensive "carbon tax" credited by analysts for the conservative coalition's victory, authorities in Australia are preparing to dismantle and consolidate the myriad global-warming schemes spawned under the previous government. However, while legislation is already being drafted, major hurdles remain before the tax on CO2 can be scrapped, sparking an outcry among businesses, state governments, and especially Australian voters, who voted overwhelmingly in favor of the new coalition and its pledge to kill the costly economic burden.
The Arctic ice sheet is expanding, much to the chagrin of climate-change doomsayers.
Wildfires occur naturally and have always been a part of the seasonal cycle in the West, but the size and intensity of the fires have dramatically increased in recent years due, in large measure, to the gross mismanagement of the national forests by the U.S. Forest Service and the incessant lawsuits of radical environmentalists that have thwarted all reasonable attempts at proper forest management.
So-called global-warming alarmists are in a frenzy after the latest climate data confirmed the Earth actually appears to be entering a potential cooling trend, sea-ice cover in Antarctica is growing to record levels, tornadoes and hurricanes are at record lows, and more. According to experts, the most recent revelations continue to make a mockery of alarmist claims — debunking United Nations theories about human-caused global warming and the wildly inaccurate supposed "climate models" used to forecast doom and gloom by forces seeking carbon taxes and more centralized government.
Obama EPA War on Coal to Shut 200+ Coal-Fired Plants, Devastate EconomyWritten by William F. Jasper
EPA regulations are set to kill jobs, send electricity rates through the roof, and make the United States more susceptible to brownouts and more dependent on foreign oil.


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If selected for publication, it will appear as soon as possible on Haaretz.com.
Let Israel's 2013 election season begin
After the next election, could the Haredim get back at Netanyahu and recommend that Labor's Yacimovich head the government?
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When Prime Minister Benjamin Netanyahu wants to express loathing for someone, he hisses the word "socialist." To him, what socialists stand for embodies the essence of evil and folly. When he lectures his interlocutors about the basics of economics, the structure of the economy, the principles of growth and the importance of competition, he sounds believable - and believing - far more so than...
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More Fantasy
The Latest
Player Updates
Terrence Ross (Tor-G-F)
Terrence Ross quiet as Lou Williams erupts
Williams was simply on fire, pouring in 36 points in 29 minutes, so it's understandable that coach Dwane Casey opted to bench Ross, who has been an under-the-radar top-80 value this season. If you need 3-pointers and a trickle of across-the-board stats, don't let this dud dissuade you from hanging onto T-Ross.
Andrei Markov (Mon-D)
Andrei Markov gets second goal of season
Markov also had two shots on goal and two penalty minutes. With two goals and 10 points in 22 games, Markov has been pretty quiet offensively this season. While he has the pedigree, its worth noting that hes 37 years old and everyone in the league slows down at some point.
Carey Price (Mon-G)
Carey Price records second shutout in win
Price leads the league with 13 wins, and he has six wins over his last seven starts. The Habs netminder is an excellent top option in fantasy leagues, with a 2.35 goals-against average and .922 save percentage. Its possible were looking at the start of one of his best seasons yet.
Loui Eriksson (Bos-RW)
Eriksson gets five SOG, struggles continue
Eriksson was also a minus-1. He has been a massive disappointment this season as he has just three goals and 11 points. Hes too talented a player to finish with a half-point per game, though. Torey Krug had seven penalty minutes and was a minus-1 in the loss.


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Agency gets good report on reducing coding errors
The Social Security Administration has spent the past 10 years cutting its rate of errors nearly in half for the medical diagnosis coding used for millions of disability benefit recipients. But now the agency has to start over.
Rather than continuing to improve its existing coding system, SSA is preparing to overhaul it to comply with new International Classification of Diseases, 10th Revision (ICD-10) medical codes, according to a new report from SSA Inspector General Patrick O'Carroll.
The ICD-10 codes are numbers of as many as 10 digits that describe a disease or medical condition diagnosis. The current SSA systems use a four-digit medical diagnosis code.
SSA faces IT management problems, IG says
CMS signals it will move to new billing codes
"We are in the planning stage for the conversion to ICD-10 standards to comply with Department of Health and Human Services' mandates," wrote James Winn, executive counselor to SSA's commissioner, in a response attached to the report.
The medical coding upgrade applies to all doctors, hospitals and federal agencies. Under HHS regulations, the coding upgrade is to be completed by October 2013, although some doctors are petitioning for more time.
The SSA conversion plans follow a positive report from O'Carroll indicating that the agency has reduced the errors in its existing use of medical codes for disability benefit recipients.
"While the diagnosis codes for approximately 5.5 percent of disabled beneficiaries or recipients were missing, invalid, or unestablished, the number of records with these errors had declined significantly over the past 10 years," O'Carroll wrote in the Dec. 8 report. "The total number of records with these errors declined by about 45 percent."
O'Carroll made two recommendations to further reduce errors, one of which is to enhance communication between SSA's Disability Control File and Supplemental Security Record. However, Winn disagreed with that advice, saying it might detract from the upcoming conversion of the coding.
"We are transitioning to ICD-10 standards, and ICD-10 will eventually supplant our current diagnosis code standards," Winn wrote. "As we proceed with ICD-10, we will work to make sure that the Supplemental Security Record and Master Beneficiary Record interface properly with the Disability Control File."
"However, if we focus on making those enhancements, we may have to redirect resources assigned to ICD-10 efforts," Winn added. "It may not be desirable for us to redirect those resources, especially considering that our current accuracy rate is very high."
About the Author
Alice Lipowicz is a staff writer covering government 2.0, homeland security and other IT policies for Federal Computer Week.
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Steve Kelman considers the costs of corruption in Mexico, China, and most developing countries -- and argues that Americans should keep their own government troubles in perspective.
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GSA's administrator talks with FCW about short-term hiring, long-term planning and Robert Frost.
Without a future vision and an appetite for risk, reforms lead down a rabbit hole. There is a better way.
VA's top tech official says he is balancing risks while trying to keep the department's online services open for business.
After five years on the job, the founding director of the Office of Government Information Services believes that a deeper understanding and acceptance of FOIA is seeping into the federal government.
The September attack, made public Nov. 10, potentially puts customer and employee personal information at risk, including addresses, Social Security numbers and emails.
The General Services Administration's Matthew Goodrich predicts more agency-driven authorizations and previews a new two-year road map.
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