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SuperTab® Oversized Tab File Folders
Smead Erasable SuperTab® File Folder 10380, Erasable 1/3-Cut Tab, Letter, Manila
Item No. 10380
Find critical files fast with SuperTab file folders. Get nearly double the labeling area of standard file folders, so you can write larger or use more lines of description. These sturdy, durable file folders fit any vertical or lateral filing system.
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|1/3-Cut Tab, Assorted Positions
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|Retail Convenience 24-Pack
|1/3-Cut Tab, Assorted Positions
LETTER SIZE - Erasable 1/3-Cut Tab, Assorted Positions
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LETTER SIZE, GUIDE HEIGHT - 1/3-Cut Tab, Assorted Positions
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Bi-lingual packaging, English and French Canadian
Designed for Canadian market - bi-lingual packaging, English and French Canadian
Designed for Canadian market - bi-lingual packaging, English and French Canadian
Item No. 10380
|Buy Online Add To My Favorites
|11-5/8" W x 9-1/2" H
|11 point manila
|1/3-cut, assorted
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|10% recycled content, 10% post-consumer waste
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Rated 5 out of 5 by 29 reviewers.
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Rated 5 out of 5 by CharlotteR Smead Super Tab File Folders I would like to write a review on the file folders. I have been using this product for a long time .I use the folders to make educational file folder games and the folders hold up very good for years. If I was to win the shopping spree I would spend it all on file folders cause I have been making games for an elementary school for 12 years. Thank you for producing a wonderful product. March 15, 2013
Smead SuperTab® Two-Pocket File Folder 87964, Extra Wide 1/3-Cut Tab First Position, Letter, Blue
Smead Erasable SuperTab® File Folder Labels 64917, White
Smead Tree Free SuperTab® File Folder 10751, Oversized 1/3-Cut Tab, Letter, Natural Brown
Smead Erasable SuperTab® File Folder Labels 64917, White


text:
Dale Earnhardt jr (88) leads Jeff Gordon (24) in Turn 4 during the NASCAR Sprint Cup series Coca-Cola 600 auto race in Concord, N.C., Sunday, May 29, 2011. (AP Photo/Terry Renna)
published Tuesday, May 31st, 2011
Here's hoping you had a great Memorial Day. Let's get to it. From the "7-Up Stinks Studios" here we go.

subset: commoncrawl


text:
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- Unique Views43
- MakeNikon
- CameraNIKON D3100
- Focal Length250.0 mm
- Shutter Speed1/99 sec
- ApertureF10
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- Original Size4608 X 3072
- Date TakenMay 26, 2012
- SubmittedDec 16, 2012
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Extra police were present at Ralston High School Wednesday, after a threat was made from one student to another.
The threat was deemed unsubstantiated by Ralston Police, but extra officers were on hand as a precaution.
Also as a precaution, parents received the following message via email.
Dear Ralston High School families,
It has come to our attention that a potential threat has been made by a student. As always we appreciate everyone keeping vigilant to help us keep on top of the information. As a result we have been working closely with the Ralston Police Department who have taken over managing the situation and the person of interest surrounding these allegations. School will be in session as scheduled on Wednesday, April 24, 2013, with an increased law enforcement presence to ensure the safety of all students, staff, and visitors. Please be assured we will continue to have a focus on the safety and security of our students.
Steve Schrad


text:
Harbour of Arts is a contemporary ceramics gallery located in the heart of the Sheung Wan art district on Hollywood Road. Initially founded in Paris in 2001 by Roger Nilsson and Alain Chiglien, Harbour of Arts aims to unite the two cities' mutual fascination for the contemporary art scene.
Their commitment to promote ceramic as a material has been supported by many international museums and institutions, such as the Victoria & Albert Museum in London, Sèvres - Cité de la Céramique, the Museum of Decorative Arts in Paris, and Icheon World Ceramic Center, in which most of Harbour of Arts artists are represented: Eva Hild, Harumi Nakashima, Steen Ipsen, Louise Hindsgavl, Wouter Dam, Nadia Pasquer and many others.


text:
Keeping the garden tidy requires a few deft moves with the right tools, and, time and again over the seasons, shrub rakes are... Read more »
Entire books have been written on the science of making compost, but it isn't as hard as people think. In five easy steps, you... Read more »
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The Fiskars® aluminum shrub rake features a slim head with uniquely tapered tines that are perfect for reaching into tight spac... Read more »
Our Eco Bin Composter features an easy-to-assemble, easy-to-use design that can simplify and speed the composting process. It i... Read more »
Our HardShell® Kangaroo® Gardening Container is perfect for all your outdoor cleanup needs — whether you're gathering yard and... Read more »
Are school fundraiser ideas keeping you up at night? A unique handmade art piece that represents your school is sure to be a p... Read more »
Creating beautiful and personal touches does not have to be difficult, especially when you have great designs to work with! Read more »
Recycle and give a new life to some of your old T-shirts Read more »
Teresa Collins is a top craft celebrity who has been featured numerous times on My Craft Channel, HSN, QVC and DIY network, wel... Read more »
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Our unique Tag Maker with Built-in Eyelet Setter features an innovative design that makes it easy to create tags perfect for gi... Read more »
By creating a few simple tags, you won't be caught at the fabric store not knowing what fabrics or yardage you have in your st... Read more »
A brocade drawstring pouch can be a beautiful and luxurious accessory or gift. Read more »
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You build raised beds, and your garden design is pure perfection. You think you'll never want to change a thing. Au contraire, my friend.
Unlike annuals which complete their life cycle in one growing season, perennials can persist for years, often with a minimum of care.
Want a beautiful flower garden that's super-easy to maintain, yet attracts important pollinators and provides visual interest all four seasons?
You've waited months for the spring to return. Finally, you can start gardening outdoors again. And if you're like me, you're definitely ready to get going.
Starting flowers and vegetables from seed is a great activity, especially when you just can't wait any longer to get your hands dirty before spring.
Come home for Earth Day, and stick around for the healthy harvest.
Venerable lilac is one of the most recognizable flower forms and fragrances in the garden.
All too often I think we take the functionality of trees for granted.
Early Spring is a great time to plant lemons, limes, oranges, and other citrus trees in southern climates.
Spring arrives early in my part of the world (Zone 7, Atlanta, GA) and before we know it, ephemerals like spring beauties, bloodroot, trilliums, Virginia bluebells, celandine poppy, rue-anemone and trout lily will be popping up...
I meet a lot of new gardeners. One of my primary garden coaching jobs is to help them embark on a successful, rewarding, and achievable gardening lifestyle.
Whether they ramble, scramble, cling or twine, perennial vines offer the opportunity to take full advantage of your vertical gardening space.
Depending on your perspective, shade is an asset or a challenge.
Peonies are perfect!
Six ways for gardeners can survive winter with style.
Power through branches with ease.
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Orange-handled scissors are a registered trademark of Fiskars Corporation.


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Does what it is supposed to do
This review is from: T-Fal SW610062 Black Sandwich/Waffle Maker
Pros: Does what it is supposed to do
Cons: Quality somewhat lower than the average T Fal products, but it works ok (feels a bit cheap).
Did you find this review helpful?
Going Gluten Free
This review is from: T-Fal SW610062 Black Sandwich/Waffle Maker
Pros: Can make waffles for the whole family of 4 in less than half an hour. Just right on the outside & fluffy inside.
Cons: Out of stock :( I have to replace the one I have because we have to go Gluten-Free.
Other Thoughts: The ONLY reason I'm looking for a new waffle maker is because my son/myself have been diagnosed with Celiac Disease & we MUST go Gluten-Free. That means replacing ANYTHING that cannot be scrubbed with an S.O.S. & no machine that I can think of could be.
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Yummy Awesomeness
This review is from: T-Fal SW610062 Black Sandwich/Waffle Maker
Pros: Stands up to cheese.
Cons: Could be a little bigger.
Other Thoughts: I put this device through its paces by making a waffle with cream cheese and mozzarella. The cheese did not burn or stick. The entire waffle came away clean.
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When the New York State Health Department issued maps this spring of the incidence of the three most common types of cancer -- colorectal, lung, and breast -- found in each county throughout the State, and another map of the incidence of breast cancer in Nassau County, by zip code, the findings probably confirmed what many already suspected for the Port Washington area, and it brought comfort to no one. Based on State data collected from 1992 to 1996, the maps showed that the incidence of lung and colorectal cancer in Nassau County was within 20% below through 20% above, the State rate, for both men and women.
"This is a great day in the history of our village club, and yes, of our village, because this club is such an important part of the village," said Sands Point Mayor Leonard Wurzel at the opening of the additional new nine holes at the Village Club of Sands Point Golf Course (formerly known as the IBM Country Club). Continuing, he noted, "It was five and a half years ago that we became owners of this magnificent property.
This year's committee has completed its selection for the members of the Athletic Hall of Fame 2000. Each year the committee gathers nominations and reviews all available data before making its final selection. The committee will be expanding next year as it continues to honor the many athletes who have helped keep Port Washington in the news.
Several local skippers and crews were part of the New York YC Race Week at Newport, which concluded this past weekend. The nine-day regatta, featuring a unique split-racing format, served as the Rolex IMS Offshore Championship and the PHRF Championship for the NYYC Trophy. Avalanche, a J-105, skippered by Craig Albrecht, from Glen Head, gave the best overall PHRF performance for the week. Never posting a less than third place finish (2, 1, 2, 1, 2, 3, 2), and winning Division H, Craig was presented with the New York Yacht Club trophy and a Rolex timepiece at the awards ceremony on the lawn of the New York Yacht Club's Harbour Court clubhouse. The trophy was awarded to the winner of the class with the most competitive division, and Division H was definitely competitive. Finishes were exciting - many of the races were as close as 20 seconds between the first place winner Avalanche and the second place finisher Different Drummer. On the last day of racing, with Avalanche in the lead by seven points, Different Drummer looked to match race at the start of the last two races, hoping to gain advantage on Avalanche. But Avalanche was able to start cleanly and hold its lead in the regatta. Mr. Albrecht credits their success to a crew that has been together for as long as 10 years, "Great boat handling and tactics, and sailing conservatively in the last two races to maintain the lead." Four of his nine crew members are local sailors: Anthony Dekkers, from Manhasset; Joe Salvatore, Manhasset; Arthur Buhr, Manhasset; and Kurt Finkbeiner, Port Washington. Many readers will be familiar with Avalanche, as she participates in Thirsty Thursday racing on Manhasset Bay, skippered by Al Albrecht, Craig's father.
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Bloomberg Businessweek, Sept. 22–29, 20142014
- Bloomberg Businessweek
- Tracy Ma
Contributed by Florian Hardwig
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Contributed by Florian Hardwig
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Contributed by Florian Hardwig
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Contributed by Florian Hardwig
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- Alexander Kada
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Cookie Ice Cream Cake
I discovered this recipe online and changed it a little to suit my family's tastes. It always gets lots of compliments because people love the hot fudge topping and unique cookie crust. My husband says it's the best ice cream cake he's ever had.
10-12 Servings
Prep: 35 min. + freezing
44 miniature chocolate chip cookies
1/4 cup butter, melted
1 cup hot fudge topping,
1 quart vanilla ice cream, softened
1 quart chocolate ice cream, softened
Crush 25 cookies; set remaining cookies aside. In a large bowl,
combine cookie crumbs and butter. Press onto the bottom of a greased
10-in. springform pan. Freeze for 15 minutes.
In a microwave-safe bowl, heat 3/4 cup hot fudge topping on high for
15-20 seconds or until pourable; spread over crust. Arrange reserved
cookies around the edge of pan. Freeze for 15 minutes. Spread
vanilla ice cream over fudge topping; freeze for 30 minutes. Spread
with chocolate ice cream. Cover and freeze until firm. May be frozen
for up to 2 months.
Remove from the freezer 10 minutes before serving. Remove sides of
pan. Warm remaining hot fudge topping; drizzle over top. Yield:
10-12 servings.
Editor's Note:
This recipe was tested with Famous Amos chocolate chip cookies.
Nutritional Facts:
1 serving (1 piece) equals 401 calories, 20 g fat (10 g saturated fat), 45 mg cholesterol, 208 mg sodium,
© Taste of Home 2014
2 of 2
Cookie Ice Cream Cake
Nutritional Facts:
52 g carbohydrate, 2 g fiber, 6 g protein.
Sweet White Wine: Enjoy this recipe with a sweet white wine such as
or a sweet
© Taste of Home 2014


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The Jewish Agency for Israel:
Since 1929, The Jewish Agency for Israel has brought 3 millions Jews on Aliyah. In August 2008, Nefesh B'Nefesh and The Jewish Agency for Israel reached a historic agreement which produced an unprecedented collaborative venture for North American Aliyah. In essence, North American Aliyah is now processed through one application overseen by Nefesh B'Nefesh. The streamlined process provides a "one-stop shop" for making Aliyah and is considerably more time efficient and convenient for Olim.
Prime Minister's Office:Nefesh B'Nefesh first formalized its partnership with the Israeli government in November 2005, when Prime Minister Ariel Sharon authorized governmental funding for Nefesh B'Nefesh on a trial basis. In September 2008, the Israeli government officially recognized Nefesh B'Nefesh in a decision designed to enhance Aliyah from Western countries. A unanimous cabinet decision gave the authority to the Ministry of Immigrant Absorption to permanently fund one third of Nefesh B'Nefesh's annual Aliyah-servicing budget. In February 2010 an additional cabinet decision was made increasing the government allocation to NBN.
Ministry of Immigrant Absorption:
The Ministry provides government assistance to Olim and returning residents, including determining eligibility for Aliyah benefits, providing personal support and financial aid. It offers resources for personal, family and community integration and assists Olim in areas such as housing, employment and culture.
Ministry of Development of the Negev and the Galilee:
The Ministry provides support for Nefesh B'Nefesh's 'Go North' program. It is responsible for developing the Negev and the Galilee, which is considered by Israel's Government as a top national priority. The Ministry focuses on advancing economically-oriented projects, with a view to creating an infrastructure of progress and prosperity that will benefit their present and future residents.
Jewish National Fund USA:
The JNF USA provides its support for the Nefesh B'Nefesh 'Go North' program. Since its founding in 1901, the JNF has evolved into a global environmental leader by planting 240 million trees, building over 200 reservoirs and dams, developing over 250,000 acres of land, creating more than 1,000 parks, providing the infrastructure for over 1,000 communities, bringing life to the Negev Desert and educating students around the world about Israel and the environment.
Russell Berrie Foundation:
Nefesh B'Nefesh recently launched its 'Go North' project in cooperation and partnership with the Russell Berrie Foundation. The foundation aims to express the values and passions of Russell Berrie through social investments in innovative ideas.
Friends of the IDF (FIDF):
In spring 2010, Nefesh B'Nefesh forged a partnership with FIDF (Friends of Israel Defense Forces) which aims to create and support social, educational, cultural and recreational programs and facilities for the young men and women who serve to defend the Jewish homeland. The FIDF also provides support for the families of fallen soldiers. Through this joint initiative, both organizations will work to provide comprehensive support for Lone Soldiers making Aliyah and help make their acclimation in the IDF and Israel as smooth and successful as possible.
Legacy Heritage Fund:
Due to the impending physician shortage expected in Israel in the coming years, Nefesh B'Nefesh in partnership with the Legacy Heritage Foundation, launched the Physician Aliyah Fellowship, whose objective is to bring close to 100 physicians from North America and the U.K.
The Marcus Foundation:
is a U.S. based philanthropic organization that focuses on Jewish causes, children, medical research, free enterprise and the community. Over the past few years this foundation, headed by Bernie Marcus, has assisted Nefesh B'Nefesh in accomplishing its goals by providing significant sponsorships.
The Irving Moskowitz Foundation:
is a charitable, non-profit foundation dedicated to improving and enriching the lives of people based on the precept, 'He who has saved one life, it is as if he has saved the world.' The Foundation was established in 1968 by Dr. Irving Moskowitz to help people in need regardless of race, creed, politics or religion.
Shavei Israel:


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Pursuant to Act 1014 of 2005, qualified first-time freshmen may elect to participate in a guaranteed 8-semester degree completion program for most bachelor's degree programs. A student must accept or waive participation in the guaranteed 8-semester bachelor's degree program. When choosing to participate in the guaranteed 8-semester bachelor's degree program, a student accepts responsibility for monitoring his/her progress toward a degree and for making choices that will lead to graduation in four years.
Degree majors that are included in the 8-semester bachelor's degree program are:
School of Education Programs:
1. Rehabilitation Education
2. Leisure Recreation
School of Arts and Sciences:
1. Art Education
2. Biology
3. Chemistry
4. Computer Science
5. Criminal Justice
6. English, BA
7. Gerontology
8. History
9. Industrial Technology
10. Physics
11. Political Science
12. Psychology
13. Social Work
14. Sociology
15. Theater and Mass Communications
16. Visual Arts
School of Agriculture, Fisheries and Human Sciences:
1. Agricultural Sciences, Options in:
Agricultural Economics
Agriculture Business
Animal Science
Plant and Soil Science
2. Fisheries Biology
School of Business and Management:
1. Accounting
2. Business Administration, Options in
Office Management


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Mavi Marmara lawyers denied Dutch visas
Thursday, February 20, 2014
ANKARA - Lawyers representing the victims of a fatal 2010 Israeli raid on an aid flotilla claim they have been denied visas to the Netherlands on their way to the International Criminal Court (ICC).
"They are not issuing us visas although we have made it clear that we are lawyers and we represent the victims of the flotilla raid," Cihat Gokdemir told AA on Thursday. "The countries where international mechanisms are based cannot prevent visitors or people in official capacity from going to these places."
Two members of the legal team, Gokdemir and Ramazan Ariturk, were not granted extensions to their three-year visas, which expired in November, despite informing Dutch officials that the ICC Prosecutor's Office - based in The Hague – had invited them for a meeting on legal action against high-ranking Israeli officials.
In May 2010, Israeli commandos killed eight Turkish nationals and an American of Turkish origin in international waters when they attacked the Mavi Marmara, a ship in a flotilla carrying humanitarian aid and construction materials to the Gaza Strip, which is under an Israeli blockade.
The event caused international outrage and soured Turkish-Israeli ties. Since then, Turkey has received an apology from the Israeli government and the two states are looking to normalize relations with a deal involving compensation for the victims' families.
Copyright © 2014 Anadolu Agency
World News:
Blast rocks college in Nigeria's Kano; casualties feared
France: Six held over 'recruitment of female jihadists'
Death sentence overturned for Bangladesh Islamist leader
Polls show pro-Scottish independence gains
Ex-MP killed in clashes in Libya's Tripoli


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Rydges Melbourne
What's On
Coming Up...
WHEN: 10th Aug 2013 to 1st Sep 2013
Get you tap shoes out. It's been almost twenty years since Hot Shoe Shuffle first wowed audiences around the world and it is shuffling into Her Majesty's Theatre this August across the road from our Doorstep!
Returning to the stage, David Atkins will play DEXTER a role originally played by Jack Webster. Jersey Boys star Bobby Fox will play SPRING, the eldest of the tap brothers, a role originally created by David Atkins and Hairspray's Jaz Flowers will play APRIL the long lost sister.
2013 marks Hot Shoe Shuffle's 21st birthday, and to celebrate that milestone David Atkins Enterprises is creating a new production which will tour Australia, with a United Kingdom and European tour to follow in 2014.
It's song and dance at its very best and most exciting. It's time to get a whole new generation on their feet cheering and applauding.
Rydges Melbourne Hotel is giving you the opportunity to see this great show with the 'Hot Shoe Shuffle Experience' Package, including accommodation, tickets to Hot Shoe Shuffle, full buffet Breakfast and cocktails to enjoy before or after the show.
Hurry Hot Shoe Shuffle is only in Melbourne for a limited season.
Speak to our reservations team on 1800 333 104 or book online today.
25 DEC - Christmas Buffet Lunch in Locanda Restaurant
19 JAN - Tennis Australian Open 2015
Local Blog
View the Rydges Blog for this hotel.Find out more


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Sweetbreads @ Babbo
- swf36d Mar 28, 2008 03:28 PM
I have been hearing so many raves about the sweetbreads at Babbo, I have to ask, what do they taste like? I'm a pretty adventurous eater, but deal breakers for me tend to be texture. I don't like food with fat on it, in fact if I accidentaly get any fat in my mouth, I'm finished eating, and texture can also be a problem. For example, I love calamari and octopus, but can't do tripe. I love chopped liver but can't do liver itself because of texture and marrow is an absoulte no. So, can anyone describe sweetbreads for me?
You won't like it. I'm being facetious here. I've never had the sweetbreads at Babbo. But I have had them at Lupa and they're great. They're not fatty in the way that marrow is, but they do have a texture not entirely dissimilar to liver--certainly not chewy like calamari or octopus. See if you can someone else to order it and take a taste, but given your texture issues I don't think it would be a good idea to get an entire order for yourself.
I actually was unimpressed the one time I had them. Their tripe on the other hand is the best in the universe.
Texture is probably more similar to liver than calamari. I don't think you'll like it. A friend of mine had a very interesting description of them. When we were eating at Craftbar, she said it tasted like cake batter. So picture something tasting like a savory cake batter while having a texture more like liver but not as granular.
I don't know how Babbo does them, but sweetbreads can be prepared in a variety of ways w/ different textures (just trying to make this more complicated for you). The most accessible way is the simplest: thinly sliced, breaded and sauteed crisp. The most squeamish preparations are (IMO) usually whole, poached/braised sweetbreads served as a main course.
re: tbear
Babbo dredges their sweetbreads in flour, fries them, and then adds a glaze with orange, then it is dusted in fennel. The treatment is somewhat similar to Chinese-American food, i.e., Orange Chicken. However, the sweetbreads are still rich and creamy, and somewhat fatty, so I am not sure OP would enjoy the texture.
Totally agree with all the posters so far-Babbo does a nice version of it but from your description of what you like and don't like-you won't like! Go with someone who does and have a taste-at the end of your meal. BTW just went there last night for second time-I wanted to give it another try since my first visit at bar last week was lackluster-and OMG- sat in dining room upstairs-what a nice time we had and the food was superb!
I just ate at Babbo tonight and it was a truly memorable experience-- sampled a bunch of different dishes with my family, but my entree was the sweetbreads. I had never eaten sweetbreads prior to tonight and Babbo's were fantastic. I consider myself an adventurous eater and wanted to try something new and flavorful-- there is a lot going on in this dish. The sweetbreads are coated in flour and fried, served in a light mushroom broth, with bacon and pickled/caramelized onions, with an orange-ish preserve. Absolutely delicious. I would compare the texture of sweetbreads (and, like you, I am sometimes turned off by peculiar textures like that of liver) to a spongy chicken. I know this might sound insulting to connoisseurs and Mr. Batali, but for the sake of comparison I'm going to say it anyway: they were similar (IN TEXTURE) to Chicken McNuggets; that crispy, fried exterior with a softer, spongy interior. The taste is completely unique and delicious, really creamy tasting. You must try them.
I haven't had them at Babbo, but I made them tonight for the first time and they tasted and had the texture of a cross between a scallop and liver. I think if you can find or make sweetbread croquettes you'd be able to eat them with no problem.


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Regulatory Development and Retrospective Review Tracker
Review of the National Ambient Air Quality Standards for Ozone
a.k.a. Ozone NAAQS Review
RIN: 2060-AP38 (What's this?)
Docket No.: EPA-HQ-OAR-2008-0699 (What's this?)
Current Phase: Pre-Proposal (What's this?)
Under the Clean Air Act, the EPA is required to review and, if appropriate, revise the air quality criteria for the primary (health-based) and secondary (welfare-based) national ambient air quality standards (NAAQS) every 5 years. On March 23, 2008, the EPA published a final rule to revise the primary and secondary NAAQS for ozone to provide increased protection of public health and welfare.
|NPRM: Sent to OMB for Regulatory Review
|NPRM: Received by OMB
|NPRM: Published in FR
|12/2014 (projected)
Children's Health
This rule is likely to address an adverse impact on childhood lifestages, including prenatal (via exposure to women of childbearing age). The potential adverse impacts are expected to be due to exposure (i.e., children and/or women of childbearing age are more likely to be highly exposed than other lifestages).
Federal Government - other agencies
Likely to be involved in the implementation of this rule.
Local Governments
Likely to be involved in the implementation of this rule.
State Governments
Likely to be involved in the implementation of this rule.
Tribal Governments
Likely to be involved in the implementation of this rule.
Some of EPA's rulemakings undergo regulatory review (What's this?), as prescribed by Executive Order 12866 and coordinated by the Office of Management and Budget (OMB). The following list describes which of this rulemaking's stages have completed review and published in the Federal Register, if any, and provides links to the review documents where available. Consult the "Timeline" section of this Web page for the dates of each review.
- NPRM - No Information Available.
- NPRM - No Information Available.
Code of Federal Regulations (CFR) Citation
Legal Authority
This site provides summaries of priority rulemakings and priority retrospective reviews of existing regulations. We update most of the site at the beginning of each month, though some data is updated more frequently if it is time sensitive. The information on this site is not intended to and does not commit EPA to specific conclusions or actions. For example, after further analysis, EPA may decide the effects of a rule would be different or it may decide to terminate a rulemaking.


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Categories: Accountants| Appraisers| Billing| Bookkeeping| Collection Agencies| See More >
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I've been looking forward to Jay + Marissa's wedding for quite some time...especially since it was the first wedding Justin and I shot in 2012, starting our wedding season off with a fantastic day! Luckily for me, I've been able to take a few months off to spend time with my kids, but I'm super excited to be back in the game again!
When Justin and I arrived at the Santa Margarita Ranch we were squealing (well, I was at least, Justin was just happy) with excitement to 1. work with Jay + Marissa on their wedding day and 2. photograph this lovely bride and groom at such an AWESOME venue! We loved it!!
It's only appropriate that Jay had Yo Gabba Gabba! Vans on for his wedding, the Director of Photography for YGG had to represent!:) Plus, Jay + Marissa met on the set of Yo Gabba Gabba, so it made perfect sense to add in this small detail!
My favorite item of the day: Since Jay + Marissa aren't huge fans of dessert they opted to have a cheese wheel "cake" instead, I thought it was brilliant!
A snapshot of us! I'm super lucky and blessed to have my favorite person and best friend shooting with me! I love you Justin Lyon;)
Congratulations to the gorgeous couple! Don't forget to check out Jay + Marissa's slideshow!
9 CommentsAdd A Comment Send To A Friend Trackbacks
sarah danaher said:
I LOVE how happy and energetic Jay+Merissa are!!(06.13.12 05:46 AM)
Sara Lucero said:
This is my favorite wedding from you! Beautiful photos and processing, sweetness, joy, fun, good style & taste! What more could you want? I love this! Great job Lyons! Yous da bombs.(06.13.12 09:00 AM)
Katie Metka said:
love! What an awesome venue and terrific photos Amelia!!(06.13.12 09:03 AM)
Miss Michele said:
WOW WOW WOW! Team Lyon does is again ;)(06.13.12 12:17 PM)
Kate Whitmore said:
When I read other blogs with this many images, I think "TOOOO MAAANY!" When I read yours, I get to the end, and I'm sad it's over. You and Justin are ridiculous. I mean...just awesome. I appreciate you two pouring into me (and 20-ish other people) last year at the Lyon Shop. I also need to tell you how much I appreciate the way you love your kids. Really, really. I wish I lived nearby so that I could soak it up (and totally adopt you as my mom-mentor) once I have little kiddos. I suppose instagram will have to do. :) Anyways...totally random post but felt like I needed to share this with you today. Hope you're having a happy SoCal Friday! Again - these images rock my face off.(06.15.12 11:46 AM)
Ruth said:
Stunning pics and what a venue!!!(06.15.12 01:51 PM)
piyush gupta said:
beautiful work.....fresh and delightful.(06.20.12 02:42 AM)
Mariah said:
I Love everything about this weddings, but especially the portraits of the bride and groom. You really captured the fun of the day. Brilliant photos!(06.21.12 04:21 AM)
Minneapolis Wedding Photographers said:
Love the sign on the first photo! Thanks for sharing these great photos. Gotten some ideas from your collection ;)(09.16.12 03:05 AM)
Listed below are links to blogs that reference this entry: Jay + Marissa Married! . TrackBack URL for this entry: http://www.amelialyon.net/darkroom/mt/mt-tb.cgi/401
Lauren + Landon's wedding was one of the last weddings we shot in 2011, it was a delightful way to end the year with two AWESOMELY in love people!!
After shooting at the temple we ventured out to the beach...it was GREAT because the beach was empty, so it was just Lauren, Landon, the sand, the water, and the sunset....LOVED it!
A HUGE congratulations to Lauren & Landon!! Click here to see their slideshow!
16 CommentsAdd A Comment Send To A Friend Trackbacks
ellen patton said:
Wow -- beautiful shots! I love the ones on the beach. And the bridesmaids' shoes. Very cool.(02.09.12 05:50 PM)
Leah said:
HOE-LEE-TAH-MOL-EEEEE! love love LOOOOOVE these! Love her dress love the bm shoes love the bouquet love the beach pics! Just lots and lots of loving for these pictures. oh thank you for sharing!!(02.09.12 11:26 PM)
Rachel Tatem said:
First: great job! I love how much fun they had. Every shot doesn't look stiff and undesired it looks relaxed and enjoyed, great job capturing that(02.10.12 05:41 AM)
Lyndzee Ellsworth said:
Fun wedding. And yes I agree on the bridesmaids shoes. I'll take them all please.(02.10.12 05:26 PM)
tara polly said:
so in love with all of the design choices in this wedding and your BEAUTIFUL photography work - wow, wow, wow! just perfect.(02.10.12 10:13 PM)
celeste M. said:
Wow! always the coolest pictures! thanks for sharing!(02.13.12 08:40 AM)
Lisa said:
Wow, so many great frames! Love those beach portraits. Well done. :)(02.14.12 02:00 PM)
LOGAN COLE said:
Awesome Job as always! Love the beach shots.(02.15.12 11:38 PM)
karleen said:
Truly stunning photographs you made here! And what a stunning couple & wedding! I see the love and the fun in every image. Thank you for sharing!(02.21.12 08:23 AM)
Kristen Morrill said:
Beautiful!!! So gorgeous! Do you know where Lauren got her dress or how I could contact her to find out?(02.22.12 11:48 AM)
Philadelphia wedding photographer said:
Every shout is just perfectly taken.(03.15.12 06:25 AM)
Bea said:
cute!! so cute!(03.16.12 04:02 PM)
Fotograf Fotopromedia said:
Gorgeous photos! A beautiful wedding of a beautiful couple.(04.04.12 05:47 AM)
Lindsay Pastor said:
I'm huge fan of your photography and this wedding is no exception to the amazing pictures you capture. Lovin the bridesmaid outfits and shoes! Where they wearing tops/skirts or dresses?(01.29.13 07:00 PM)
Listed below are links to blogs that reference this entry: Lauren + Landon Married! . TrackBack URL for this entry: http://www.amelialyon.net/darkroom/mt/mt-tb.cgi/391


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Could Australian dollar lose status amongst commodity currencies?
- Details
- Category: Australian Dollar Articles
- Published on Monday, 21 January 2013 10:20
- Written by Sam Coventry
The pound vs Australian dollar exchange rate is unchanged on Friday's closing rate at 1.5093.
The euro vs Aussie is 0.14 pct down at 1.2655.
Against the US dollar the Australian currency is 0.14 pct higher at 1.0525.
Please be aware that these are spot market rates; banks will charge a spread on the rate at their discretion. An independent provider is able to deliver the best possible rates by negotiating on the spread thus delivering the best possible exchange rates.
NZD could be preferred to AUD in commodity currency space
A commodity currency is one that is deemed to be driven by flows in the commodity market; Australia's massive mining sector is key in this estimation. Other currencies that fall in this bracket are the NZD, CAD and ZAR.
|Live Charts and
Aus Exchange Rates
Exchange Rate
Forecasts 2013:
According to analysis released this morning by Lloyds Bank notes how the AUD continues to trade with a soft tone, and further weakness could be expected:
"We maintain the view that if AUD yields drop further it may lose its status as the preferred commodity currency among the majors, with the CAD and NZD potentially being preferred. Q4 CPI released on Wednesday will be a focus ahead of the RBA meeting on 5th Feb. Market is expecting inflation to rise to 2.4% y/y, which should help reduce market expectations of RBA rate cuts which would be AUD supportive."
Bank of Japan will be of importance to AUD
According to Caxton FX the aussie dollar will take further guidance from the Bank of Japan's monetary policy decision.
"The coming overnight session will see the Bank of Japan announce its next move as far as monetary policy is concerned. The market is already expecting pretty aggressive monetary easing measures, so the AUD may not benefit quite as much as you might think," says Richard Driver at Caxton FX.
Tuesday night also brings a key quarterly Australian inflation reading, which is likely to be weak. We should see speculation surrounding another RBA rate cut intensify.
Related: Pound / Aus Dollar
- Australian dollar under the cosh as iron ore prices slump; New Zealand dollar continues to enjoy benefits of buoyant dairy industry
- Pound sterling down versus Australian and New Zealand dollar's today; but 'weakening AUD drivers remain in place'
- Outlook for the Australian dollar likely to be driven by expectations over interest rate cuts at the Reserve Bank of Australia
Latest on The Economy News
- Heritage Oil PLC + XCITE ENERGY LIMITED: HOIL Updates on Tax Position, XEL Fails to Impress Investors Latest Update
- Thomas Cook Group plc: TCG Faces Conflicting Signals on the Charts
- Tech Alert on Gulf Keystone Petroleum Limited: For GKP "This bearish signal indicates that the stock price may fall"
- Imagination Technologies Group plc backed by Intel Corporation Backing: Why IMG is a Buy
- ARM Holdings plc vs Intel Corporation: Sell Rating on ARM Confirmed as INTC Launch XMM 7260
- HSBC Holdings plc: HSBA shows "little in the chart to suggest that a sudden push higher is imminent"
- Vodafone Group plc: VOD Outlook Adjusted to Factor in New Share Count


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-- Diana Kohnle
(HealthDay News) -- A birthing class can help settle any
pre-birth jitters and prepare first-time couples for the pending
The American Academy of Family Physicians says a birthing class
Copyright © 2013
HealthDay. All rights reserved.
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Mitt Romney Flies Coach, Is Reminded Why He Shouldn't Fly Coach
So, Mitt Romney was flying coach — first off, huh? – en route to Boston, and he happened to be sitting next to the smartest lady in the country who knows just what he needs to do to fix our health care system.
Oddly enough, he wasn't all that psyched to have her outline her plan in minute detail…
According to Ms. McClanahan, about an hour into the flight — which Mr. Romney mostly spent reading USA Today and using an iPad while wearing headphones — she told him her idea for improving the American health care system: slashing overhead costs by switching to an electronic billing system.
"He looked at me blankly and said, 'I understand,' then put his iPad headphones in and kept reading," she said.
While Ms. McClanahan said Mr. Romney was probably exhausted, she was disappointed he showed so little interest. Even another passenger's request for a restaurant recommendation in Boston elicited little from Mr. Romney, she said. "I can't give you any," he said, according to Ms. McClanahan. "You'll have to ask someone else."
Oh my God, I am sooooo on Mitt Romney's side here. I don't think I've ever been more on Mitt Romney's side about anything ever. I'll go even further and say that if there were a national election right over whether or not people like Mitt Romney should get to not field annoying small talk questions and half-thought-through national policy suggestions, Mitt Romney would get all my votes. (Yes, I'd sneak back into the polling booth to vote multiple times.)
Now, I suppose one can make the argument that Romney was kind of asking for annoying people to say annoying things to him given the fact that he is a billionaire presidential candidate flying coach for some reason. But I would argue that that's just blaming the victim. Even billionaire presidential candidates flying coach for some reason should get play with their iPads in peace. I'm relatively certain that if iPads and flying coach we're invented back in the olden days, that right would have been spelled out explicitly in the Declaration of Independence.
Photo by Bill Clark/CQ-Roll Call Group/Getty Images
Tags: Mitt Romney, Primaries, Republicans, Science & Technology, Transportation
About Us
Comedy Central's Indecision is the network's digital hub for news, politics and other jokes: we're here, we're everywhere. We're not affiliated with any television show. We're affiliated with ourselves.


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Scrying: The ancient art of clairvoyance achieved by concentrating on an object - usually one with a reflective or semi-reflective surface (mirror, crystal ball, water, etc.) - until visions appear. Magicians and witches of all ages have practiced scrying. The term scrying comes from the English word descry , which means 'to make out dimly' or 'to reveal.' The services of the scryer typically are sought for predictions of the future, answers to questions and tracking down criminals, just to name a few.
Goddess Portal Scrying Mirror
This deluxe 11 inch diameter non-black scrying mirror features the traditional Goddess and her portal to the astral realm. Makes a great altar tool or home decoration.
Item #: TF217, Price: $39.99
Have you seen our current specials?
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Click here for the live stream:
The Pakele Live! stream starts every Thursday at 6:30PM Hawaii Standard Time. Please email firstname.lastname@example.com for shout-outs and comments.
Since 2006, Pakele Live! has been sharing some of the best in Hawai`i's music to a global audience. Watch televised episodes of Pakele Live on Oceanic OC16 (Channel 16, Digital 96 and HD 1016). The series was designed to showcase the beauty and richness of Hawai'i through its music, language, and hula. Hawai'i's arts and crafts play a part of the Pakele experience as well. What makes the Pakele series very special is the fact that we are sharing this with people around the world via the live internet streaming that takes place every Thursday night. We've had viewers as close as the neighbor islands and as far-reaching as Japan, London, Australia and even those serving our nation in Iraq.


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In November, a judge cleared accomplished MSU-Mankato football coach Todd Hoffner of felony child porn charges, ruling that the videos were "private, family speech." After he was charged in August, Hoffner was put on paid administrative leave and assistant Aaron Keen was named interim head coach.SEE ... More >>
SEE ALSO:-- Todd Hoffner, MSU-Mankato football coach, allegedly shot sex videos of his own young kids-- Todd Hoffner dealt with sex photo scandal while coaching at UW-Eau ClaireThis morning, Melodee Hoffner, wife of MSU-Mankato football coach Todd Hoffner, held a press conference and said her husban ... More >>
SEE ALSO: Todd Hoffner, MSU-Mankato football coach, allegedly shot sex videos of his own young kidsMSU-Mankato head football coach Todd Hoffner faces two felonies after allegedly shooting pornographic videos of his three young children. But it turns out this isn't the first time coach Hoffner has be ... More >>
Photo by Ben ClarkThough he still calls Eau Claire home, Justin Vernon has been reluctant to perform many shows in his much-written-about hometown since his band Bon Iver achieved worldwide recognition. It turns out he was just waiting for the right time: On December 12 and 13, as somewhat of a h ... More >>
Thousands come to watch, so someone has to build the rinks
"No Negro's Allowed"Mark Prior has cheesed off a lot of folks in Abbotsford, Wis., and not just because he wants to open a strip joint right next to City Hall and the library. The real issue is that he posted a "No Negro's Allowed" sign on the front door of the property. (Yes, we see that he ... More >>
Dr. Tom Hilton went all Joseph Smith on the Eau Queer Film Festival.University of Wisconsin-Eau Claire professor Tom Hilton seriously stepped outside of his role teaching "information systems" to deliver another kind of lecture -- the homophobic kind. His target: Senior Women's Studies stude ... More >>
The former Picked to Click finalists are calling it quits.
Bad choice: A Wisconsin man traded a Starbucks gift card for a fatal dose of heroin.
Attempts at state regulation fail, so activists try something new
How three Midwestern boys reached jazz nirvana
For years it has been whispered that the 1976 slaying of American Indian Movement activist Anna Mae Aquash was an inside job. Now a new rash of accusations aims squarely at local heroes Clyde and Vernon Bellecourt.
Back when no one believed in global climate change, local meteorologist Bruce Watson sounded the alarm. Now that everybody's predicting disaster, he's bucking the trend again.


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While those of us staying put for Easter will happily make do with accessorizing our cosy looks with a hot-water bottle, and potentially ski boots, those lucky enough to jet off for the break need look no further as we've rounded up the best holiday buys below. With our Fashion Editors gearing up for both city and beach breaks, we've asked them what they'll be packing this weekend.
For city breaks we're taking prints to the max, with stripes, monochrome and navajo prints reigning supreme, and packing fancy flats to make sightseeing that little bit prettier! When it comes to hitting the beach, we'll be making a statement with colourblocking swimsuits and haute cover-ups, making the sun-lounger to sun-downer cocktail transition stylishly simple.
Caroline Ferry's City Break Essentials
Top Row: Yellow cardigan £236 Carven, Embellished jacket £89 Monsoon, Striped dress £14.99 H&MBottom Row: Striped trousers £34.99 Mango, Sik leopard tee £185 Equipment, Leather tote £85 Autograph at Marks & Spencer,Tassel slippers £225 Caroline Issa for L.K Bennett
Charlie Miller's Beach Holiday Buys
Top Row: Scallop edge two-tone swimsuit £36 Topshop, Printed bandeau bikini £185 Mara Hoffman, Snakeskin sandals £174 ASH, Sunglasses £259 Swarovski, Bottom Row: Belted colour-block dress £129 Ted Baker, Shorts £32 Topshop, Colour-block bandeau swimsuit £330 Roksanda Ilincic,Orange maxi dress £19.99 New Look
And finally, jewellery worth packing...
From left: Orange earrings £90 Isabel Marant, Gold bead cuff £14 Miss Selfridge, Knuckle duster ring £12.50 Dorothy Perkins, Necklace £25 Topshop,Leather wrap bracelet £80 Marc by Marc Jacobs, Pink drop earrings £150 Anton Heunis


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Originally posted 02/24/2012 06:30PM
Fans recognize Patrick Wilson from his CBS drama A Gifted Man, but his friends know him as a die-hard Van Halen fan – with a family cover band to boot.
"You're defined by your older brothers or sisters' music," explains the actor, 38, who was turned on to the band decades ago by his elder brothers Paul and Mark. "It's always been this hilarious passion."
Driven by their love of music and all things Van Halen (Wilson says that his surgical hat in A Gifted Man is made from a Van Halen t-shirt!), the brothers formed their own cover band – dubbed, appropriately, Van Wilson – a few years ago, and play gigs whenever they can.
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6 Killer Google Chrome Extensions for Social Media Addicts
About a year ago, Google launched Chrome, their super fast, open source web browser. Since then it has grabbed just over three and a half percent of the world's web browser market, according to Net Applications. That's not bad, but still puts Chrome firmly in fourth place behind Internet Explorer, Firefox, and Safari. One of the reasons why Chrome has been stuck in fourth place: extensions -- Chrome hasn't got them.


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Welcome to the library's list of widgets and plug-ins. We hope this guide will help you discover and use the wealth of information resources provided by the library. Librarians can assist you further, also. We hope to hear from you!
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If you can't access a library resource, call 281-283-3910, use Ask a Librarian, or see our Database Access guide.
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OneSearch Quick bookmarklet
Ever visited a web page and wanted to find more scholarly information on the same subject? After you add this bookmarklet to your browser, clicking it will automatically search UHCL OneSearch for the title of the page you are visiting. (You can edit the query if you like, to remove or add other keywords.)
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Paul Stastny.We have a goal -- to brighten up your week by giving you a chance to win one of five pairs of tickets to see your Colorado Avalanche take on the San Jose Sharks, last year's playoff opponent, on Wednesday night. How can you qualify? By telling us in the comment section below who ... More >>
Carlos Boozer contemplates how good it'll feel to make the Nuggets eat shit.The 2009-2010 season started out so promisingly for the Denver Nuggets that a lot of us looked at a Western Conference Finals rematch with the L.A. Lakers as a virtual lock. That's all over -- and not just because th ... More >>
The photo and message atop Tom Mauser's ad (click to enlarge).Last year marked the tenth anniversary of the shootings at Columbine High School -- the sort of round number the media can't resist. As such, there were a number of notable commemorations, including the release of two books on the ... More >>
Thanks, Rob.Today, we've created a new Denver Blogs category for our daily blog roundup, rather than wedging the words in the headline. What an exciting change. So... the Avs shock the hockey world by defeating the top-seeded San Jose Sharks on the road in game one of their playoff series -- ... More >>
Photo by Kenny Be Colorado will see Lord Stanley's Cup in 2010 if fans just keep looking up. The first game of the first round of the NHL playoffs is scheduled today and hockey wizards are saying that the San Jose Sharks will take the Colorado Avalanche in five. I'm much more optimistic and ... More >>
Academic All-Americans make the grade while breaking a sweat.


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Search Library Catalog via Searchworks
SearchWorks, the Stanford University Libraries and Academic Information Resources next generation library catalog, makes it very easy to limit results to online resources.
Stanford Links
Stanford Links:
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Center for Comparative Studies in Race and Ethnicity (CCSRE)
Link to Anthropologie Internet Guide
New Books - Recently Recieved
Collecting across cultures : material exchanges in the early modern Atlantic world
Call Number: GN406 .C65 2011
Green Library
Global urbanization
Call Number: HT361 .G57 2011
Green Library
Making volunteers : civic life after welfare's end
Call Number: HN90 .V64 E425 2011
Green Library
Print Bibliographies
Cultural anthropology : a guide to reference and information sources
Call Number: Green - Stacks Z5111 .J33 2007
International Bibliography of Anthropology
Call Number: Green - Social Sciences Resource Center (Non-circulating) Z7161 .I593 V. 54 2008
At head of title on cover: BLPES Bibliographie internationale d'anthropologie
See Database Page for Online the IBSS: International Bibliography of the Social Sciences
At head of title on cover: BLPES Bibliographie internationale d'anthropologie
See Database Page for Online the IBSS: International Bibliography of the Social Sciences
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The 2010 health care laws require non-grandfathered group health plans and health insurance issuers offering group or individual health insurance coverage to provide certain preventive health benefits from the first dollar of coverage, with no patient cost-sharing (copayments, coinsurance, deductibles, etc.), when those benefits are delivered in-network.
This newsletter discusses recent guidance on women's preventive services. Please click above to read more.
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sustaining memberships
The Town Hall is a non-profit organization supported by contributions and governed by a volunteer Board of Trustees. Individual contributions are an important source of support. Join us by becoming a Sustaining Member. All contributions are deductible to the full extent of the law.
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For more information on Sustaining Membership Categories click here, or contact Helen Morris at 212-997-1003 x10 or if you prefer, use our Town Hall Sustaining Membership Form to create a print-ready form to designate your gift.


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Topical or Ablative Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Squamous Intraepithelial Lesions
This study has suspended participant recruitment.
(FDA review)
AIDS Malignancy Clinical Trials Consortium
The EMMES Corporation
Information provided by (Responsible Party):
AIDS Malignancy Clinical Trials Consortium
ClinicalTrials.gov Identifier:
First received: May 8, 2014
Last updated: October 7, 2014
Last verified: October 2014
- Full Text View
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Show Detailed Description
This randomized phase III trial compares topical or ablative treatment with active monitoring in preventing anal cancer in patients with human immunodeficiency virus (HIV) and high-grade squamous intraepithelial lesions (HSIL). Anal HSIL is tissue in the anal canal that has been damaged by infection with human papillomavirus (HPV) and is at risk for turning into anal cancer. It is not yet known if treating HSIL is more effective than active monitoring in preventing patients from developing anal cancer.
Anal Cancer
High-grade Squamous Intraepithelial Lesion
HIV Infection
Human Papilloma Virus Infection
Drug: imiquimod
Drug: fluorouracil
Procedure: infrared photocoagulation therapy
Procedure: thermal ablation therapy
Procedure: laser therapy
Other: clinical observation
Other: laboratory biomarker analysis
Procedure: quality-of-life assessment
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
|Official Title:
|ANCHOR Study: Anal Cancer/HSIL Outcomes Research Study
Resource links provided by NLM:
MedlinePlus related topics: Anal Cancer Cancer HIV/AIDS
Drug Information available for: Fluorouracil Imiquimod
Genetic and Rare Diseases Information Center resources: Anal Cancer Cervical Intraepithelial Neoplasia Rectal NeoplasmU.S. FDA Resources
Further study details as provided by AIDS Malignancy Clinical Trials Consortium:
Primary Outcome Measures:
- Time to anal cancer [ Time Frame: Time from randomization to diagnosis of anal cancer, assessed up to 5 years ] [ Designated as safety issue: No ]The log-rank test will be used to compare the treatment and control arms with respect to time to detection of anal cancer. For each arm, the hazard rate and its 95% confidence interval will be estimated. The proportional hazards model will be used to assess the association of study site, lesion size, lesion location, nadir CD4 level and gender with time to detection of anal cancer.
Secondary Outcome Measures:
- Incidence of adverse events for each treatment [ Time Frame: Up to 5 years ] [ Designated as safety issue: Yes ]Summarized by type of adverse event and severity grade for each of the treatments. For adverse events that occur in more than 5% of any of the treatments, the Poisson rates will be used to estimate the number of adverse events per unit time and the binomial proportion and its 95% confidence interval will be used to estimate the proportion of participants who reported the event.
- Quality of life assessed using the Functional Assessment of Incontinence Therapy - Fecal (FAIT-F) questionnaire [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]Descriptive statistics will be used for subscales and scores for each arm and each time point. General estimating equations will be used to compare the two arms with respect to subscales and scores across time points and adjustment for intra-participant variability.
Other Outcome Measures:
- Viral factors in HSIL progression to cancer [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]Descriptive statistics will be used to describe the integration locus of HPV In the invasive cancers and whether they differ from those of the overlying HSIL. Descriptive statistics will also be used to determine if the loci differ in HSIL that have progressed and concurrent HSIL biopsies that did not progress. In each case only tissues that contain HPV 16 will be analyzed.
- Host factors in HSIL progression to cancer [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]Linear models will be fitted for each gene. Moderated t-statistics, fold-change and the associated p values will be calculated for each gene. Since thousands of genes will be tested, false discovery rate (FDR)-adjusted values will be calculated using the Benjamini-Hochberg method. FDR values indicate the expected fraction of falsely declared differentially expressed (DE) genes among the total set of declared DE genes, i.e. FDR = 0.15 would indicate that 15% of the declared DE genes were expected to be false due to experimental noise instead of actual differential expression.
- Host and viral biomarkers of progression from HSIL to cancer [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]
- Behavioral risk factors for HSIL progression to cancer [ Time Frame: Up to 5 years ] [ Designated as safety issue: No ]For each risk factor of interest, Fisher's exact test or Pearson's chi-square test will be used to determine if there is an association. Factors associated with invasive anal cancer at the 0.10 significance level will be incorporated into a logistic regression model to determine if they are independently associated with invasive anal cancer. Cox regression analyses will also be used to evaluate the association between risk factors and time to diagnosis of invasive anal cancer.
|Estimated Enrollment:
|Study Start Date:
|September 2014
|Estimated Study Completion Date:
|June 2022
|Estimated Primary Completion Date:
|June 2022 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Arm I (treatment)
Patients are directed to receive either topical or ablative treatment at the discretion of the clinician. Patients receiving topical treatment apply imiquimod intra-anally, peri-anally or both thrice weekly for up to 16 weeks, fluorouracil twice daily for 5 days every 2 weeks for up to 16 weeks, or trichloroacetic acid every 3 weeks up to 12 weeks. Patients receiving ablative treatment using infrared coagulation, hyfrecation/electrocautery, or laser. Patients may undergo excision under anesthesia if the clinician believes none of the other treatment approaches will be effective. The number and timing of such treatments will be at the discretion of the investigator. Patients with persistent HSIL should continue a protocol-approved treatment or a new protocol treatment should be considered.
Drug: imiquimod
Applied topically
Other Names:Drug: fluorouracil
Applied topically
Other Names:Procedure: infrared photocoagulation therapy
Undergo infrared coagulation
Other Names:Procedure: thermal ablation therapy
Undergo hyfrecation/electrocautery therapyProcedure: laser therapy
Undergo laser therapy
Other Name: therapy, laserOther: laboratory biomarker analysis
Correlative studiesProcedure: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment
Active Comparator: Arm II (active monitoring)
Patients undergo active monitoring with examinations every 6 months. Every 12 months, patients undergo biopsies of visible lesions. Patients have cytology sampling performed at every visit.
Other: clinical observation
Undergo active monitoring
Other Name: observationOther: laboratory biomarker analysis
Correlative studiesProcedure: quality-of-life assessment
Ancillary studies
Other Name: quality of life assessment
Show Detailed Description
|Ages Eligible for Study:
|35 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- HIV-1 infection, as documented by any federally approved, licensed HIV test performed in conjunction with screening (or enzyme-linked immunosorbent assay [ELISA], test kit, and confirmed by western blot or other approved test); alternatively, this documentation may include a record that another physician has documented that the participant has HIV infection based on prior ELISA and western blot, or other approved diagnostic tests; an approved antibody test will be used to confirm diagnosis; if the physician is treating a patient with combination antiretroviral therapy (cART) with a history of HIV positivity based on an approved antibody test then repeat antibody confirmation is not necessary
- No history of treatment or removal of HSIL
- No history of anal cancer or signs of anal cancer at baseline, and no history of penile, vulvar, vaginal or cervical cancer
- Biopsy-proven HSIL at baseline
- At least one focus of HSIL must be identified that is not within a condyloma that may be treated after enrollment into the study
- For females, cervical cytology (if having a cervix) and gynecologic evaluation including vulvar examination within 12 months prior to enrollment
- Eastern Cooperative Oncology Group (ECOG) performance status =< 1 (Karnofsky >= 70%)
- Life expectancy of greater than 5 years
- Absolute neutrophil count: >= 750/mm^3
- Platelets: >= 75,000/mm^3
- Hemoglobin >= 9.0 g/dL
- Women of childbearing potential must have a negative urine pregnancy test within 7 days of initiating study treatment if they have been randomized to the treatment arm; all women of childbearing potential must agree to use a reliable birth control method (oral contraceptive pills, intrauterine device, Nexplanon, DepoProvera, or permanent sterilization, etc., or another acceptable method as determined by the investigator) during the entire period of the trial (5 years), and must not intend to become pregnant during study participation and for 3 months after treatment is discontinued; all participants must be willing to comply with an acceptable birth control regimen as determined by the Investigator
- Men randomized to the treatment arm should not father a baby while in this study; men who could father a child should use at least two forms of birth control for 3 months after stopping all study treatment
- Ability to understand and the willingness to sign a written informed consent document
- Participant is willing to be randomized and able to comply with the protocol
- Clinician is comfortable with either following patient for up to 5 years without therapy or treating patient for up to 5 years
Exclusion Criteria:
- Inability to provide informed consent
- Patients who are receiving any other immunomodulatory investigational agents within the 4 weeks before randomization enrollment, other than investigational antiretroviral agents for HIV
- History of anal cancer, penile, vulvar, vaginal or cervical cancer
- History of prior treatment or removal of anal HSIL
- Participant has symptoms related to HSIL and would benefit more from immediate treatment than from entry into the study and potential for randomization to active monitoring arm
- Current systemic chemotherapy or radiation therapy that potentially causes bone marrow suppression that would preclude safe treatment of HSIL
- History of HPV vaccination, or intention to receive an HPV vaccine during study participation
- Prior pelvic radiation therapy that would preclude radiation therapy if anal cancer develops
- Warts so extensive that they preclude the clinician from determining the extent and location of HSIL
- Participant plans to relocate away from the study site during study participation
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02135419
Please refer to this study by its ClinicalTrials.gov identifier: NCT02135419
|United States, California
|University of California at San Francisco Anal Dysplasia Clinic
|San Francisco, California, United States, 94115
Sponsors and Collaborators
AIDS Malignancy Clinical Trials Consortium
The EMMES Corporation
|Principal Investigator:
|Joel Palefsky, MD
|AIDS Associated Malignancies Clinical Trials Consortium
More Information
No publications provided
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on November 24, 2014
No publications provided
|Responsible Party:
|AIDS Malignancy Clinical Trials Consortium
|ClinicalTrials.gov Identifier:
|NCT02135419 History of Changes
|Other Study ID Numbers:
|Study First Received:
|May 8, 2014
|Last Updated:
|October 7, 2014
|Health Authority:
|United States: Food and Drug Administration
United States: Federal Government
United States: Institutional Review Board
United States: Data and Safety Monitoring Board
Additional relevant MeSH terms:
Acquired Immunodeficiency Syndrome
Anus Neoplasms
Communicable Diseases
HIV Infections
Papillomavirus Infections
Uterine Cervical Dysplasia
Virus Diseases
Anus Diseases
Colorectal Neoplasms
DNA Virus Infections
Digestive System Diseases
Digestive System Neoplasms
Gastrointestinal Diseases
Gastrointestinal Neoplasms
Genital Diseases, Female
Immune System Diseases
Immunologic Deficiency Syndromes
Intestinal Diseases
Intestinal Neoplasms
Lentivirus Infections
Neoplasms by Site
Precancerous Conditions
RNA Virus Infections
Rectal Diseases
Rectal Neoplasms
Retroviridae Infections
ClinicalTrials.gov processed this record on November 24, 2014


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Robyn has made it to America!!! With thanks to all of you we have raised the money to send her over there for much needed treatment.
Please continue to show your support as much as you can as we need to keep raising money so that Robyn can continue to get every possible opportunity. Thank you all so much.
Robyn is now 9 yrs old. At the age of 3 Robyn was diagnosed with Neuroblastoma. A tumour was found in her chest and head and tests showed that the cancer had already spread to many parts of Robyn's body. This meant Robyn's cancer was stage 4, this put her survival rate at 20%-30%.
Robyn has since endured Chemotherapy, Surgery, Stem cell transplant, Radiotherapy and 6 months on tablets to try to kill any remaining cancer cells.
70%-80% of children diagnosed with Neuroblastoma will relapse!!!
Robyn stayed in remission for 4 and a half years but on the 9th of July 2013 we got the devastating news that Robyn has relapsed.
The treatment available in Ireland for children that relapse is very limited but there are cutting edge trial treatments available in hospitals in America and Europe. We are desperately trying to raise funds for these treatments – the treatments there start at €350000 and can end up costing double this or more.
We need people to make donations, organise events, give raffle prizes, volunteer your time to make collections at events – anything you can do to help – we need
Robyns Life Trust wrist bands
We are now selling Robyns Life Trust wrist bands. They are available in green and purple – please contact us via facebook or via email if you are interested in purchasing wrist bands for sale email@example.com
Four Star Pizza Finglas
Four Star Pizza Finglas are offering a great deal every Thursday for the month of September. 14″ pizza with 2 toppings for €10, €5 will go to Robyn. Please show your support for this great deal. Go On – treat yourself – you all deserve it after all of your hard work.


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Return to story
NASA^BENT^0027^EENT^s Curiosity rover found evidence for an ancient, stream on Mars, including the rock outcrop pictured here,
THE NASA Mars Science Laboratory rover named Curiosity has hit an astronomical home run. With only two months under its belt since landing on Mars, Curiosity already has made a major discovery: NASA announced it found a dried-up river on the Martian surface.
While earlier missions found evidence that water existed on Mars long ago, this discovery is the first to uncover rocks and gravel from an ancient river, a sort of smoking gun showing that flowing water definitely did exist in the planet's distant past.
Scientists studying the photos of the rocks and gravel estimate that water
Such an amazing discovery clearly shows that Mars was once a much more hospitable place than it is presently, and again raises the question about life beginning on the Red Planet. Mars is a cold and dry place today, so understanding the contrast between then and now is the key to learning why it changed so dramatically, and may help us understand Earth's changing climate as well.
Looking at these photos and wondering if life might have begun on our next-door planetary neighbor is certainly exciting and well worth contemplating.
I remember the excitement when NASA's Viking 1 and 2 spacecraft touched down on Mars 36 years ago. The Vikings sent back the first-ever photos from Mars' surface, showing a stark, alien world that captured the attention of our nation during its bicentennial in 1976.
The Curiosity rover, a much more sophisticated machine than its Viking relatives, continues the Vikings' tradition of trailblazing new paths as it drives across the Martian surface searching for signs of life during its two-year mission. It has been an amazing mission so far, only two months since landing, and there's much more to come!
You can still see Mars this month as it continues to be visible very low in the southwestern sky after sunset. Look for the Red Planet to be near the crescent moon about an hour after sunset on Oct. 18.
Venus and Jupiter continue to dazzle in the mornings before sunrise, with Jupiter high in the sky and Venus closer to the horizon. Look for Jupiter to be near the moon during the mornings of Oct. 5-6.
Venus gleams brightly this month before sunrise above the eastern horizon. Look for it to be near the moon during the mornings of Oct. 11-13.
David Abbou of Stafford County is a volunteer with the NASA/JPL Solar System Ambassadors Program and is a member of the Rappahannock Astronomy Club. Contact him at
Email: firstname.lastname@example.com.


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By GET Management at 20:42 on 21/02/12
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Dance Fit is a popular Class for all ages and for all levels of dancers. The classes have taken on people whom have never danced before but the easy-to-learn system enables everyone to get the moves very quickly as well as remember the dance routines. Each lesson uses repetition to teach the dance moves.
The warmup at the beginning of the class, stretches and strenthens each part of your body before you begin. Each class you will run through dances you have learnt and build up a handful of fully revised dances this keeps the class at a great pace for burning calories, toning the body and release endorphines!
This year Dance fit will open their doors to all ages . The Dance Fit class has a relaxe friendly environment and a chance to meet new people.
Dance fit doesnt just improve your fitnesss it improves your body movements and your memory. It is a great active way to keep i shape and learn something at the same time.
Every Tuesday evening 7-8pm
The Teen and Twenty,
Riverlawn Road
Kent TN9 1EP
£6 for an hour
Call 07827793237 for more info
Date: Tuesday, February 28, 2012
Repeats: Every Week until Tuesday, December 18, 2012
£80000.00 - £100000.00 pa + £150,k OTE
£70,000 - £85,000 + package
£70,000 - £85,000 + package