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|Budget Passes House and Senate
|Congressional Biomedical Research Caucus H. Res 83 Co-Sponsors
Co-sponsors of H. res. 83, international by rep. George Gekas, (R-PA) which calls for the doubling of the NIH budget in five years include:
Brian Bilbray (R-CA)
Listed below are those Members of Congress who have recently joined the bi-partison bi-cameral, no dues Congressional Biomediacl Research Caucus. This brings total membership to 72
Bob Etheridge (D-NC)
Budget Passes House and Senate
During the budget debate in both the House and the Senate, amendments were offered in support of greater funding for biomedical research. Representative Joseph Kennedy (D-MA) introduced an amendment calling for "funding for the National Institutes of Health at least equal to the institutes' annual professional judgment, which is the best and most reliable estimate of the minimum level of funding needed to sustain the high standard of scientific achievement attained by the National Institutes of Health." This amendment failed by a vote of 123-306, primarily because it would have broken the budget agreement, but it put the NIH on record and challenged appropriators to raise their sights for the NIH. The budget passed the House by a vote of 333-99.
In the Senate, Senators Connie Mack (R-FL) and Dianne Feinstein (D-CA) introduced a Sense of the Senate Amendment calling for the doubling of the NIH in five years and $2 billion to fund the NIH in FY'98. The amendment, which passed 98-0, is not law, but helps to chart the direction for the Appropriations Committee when it makes its decisions about funding. The Joint Steering Committee for Public Policy released a Congressional Liaison Committee (CLC) Alert to 2000 scientists, encouraging them to contact their Senators to support the amendment. The floor debate regarding this Amendment invoked passionate and sometimes personal discussion about the importance of basic research and specifically the NIH. In the midst of the Senate debate, Senator Arlen Specter (R-PA) and Senator Tom Harkin (D-IA) announced that they planned to offer an amendment to the Senate Budget Resolution that would ensure that the NIH receive a 7.5% increase, $1.1 billion above 1997 funding levels, which they declared as their goal earlier in the year. This amendment would have been paid for by decreasing allocations to other programs. The amendment failed by a vote of 63-37 because it would have altered the budget agreement negotiated by the Administration and the Congress.
The House and the Senate Appropriations Committees will now work to complete their bills which provide funding for the various agencies. This process may last through the fall and will be watched carefully for potential increases in science funding.
House Passes Science Reauthorization Bills
NIH Reauthorization
At the hearing, Varmus described the process by which the NIH makes its budget decisions each year. He made ten observations about the process:
The National Bioethics Advisory Commission (NBAC) met on May 2 to discuss its progress in developing recommendations to the President on the issue of cloning. Harold Shapiro, President of Princeton University, is the Chairman of the NBAC; ASCB member Carol Greider is a member of the commission and Chair of the Ad-hoc Committee of the NBAC which is specifically considering cloning. The commission is on schedule to develop a recommendation within the 90-day deadline that the President imposed.
The Commission solicited the recommendations of 60 scientific organizations and interest groups including the ASCB; of these, they received 31 responses and have considered 19 closely. Most agreed that there should be a moratorium on human cloning, but no one called for legislation in this regard. Most also suggested that there not be restrictions on current research activities, including animal cloning. Many letters called on the Commission to define cloning carefully. Recommendation "(1)" above in Paul Berg's response to Greider refers to specific practices involving nuclear transfer clonning.
ASCB/MBL Minority Fellows Announced
Senior Scientist to Support NASA. Information Dynamics, Inc. (IDI), a rapidly growing high-technology NASA contractor, is seeking a Senior Scientist in Washington, DC, to provide scientific support for the National Space Biomedical Research Institute (NSBRI) Peer Review Process Support Contract.
Responsibilities include recruiting panelists for independent peer review of research proposals submitted to the NSBRI, reviewing and synopsizing these research proposals, conducting peer review panels and site visits for the NSBRI, and developing and reviewing critiques of research proposals in addition to there responsibilities.
Requires PhD in a biomedical or related field along with five years demonstrated experience working with the biomedical scientific community and an in-depth knowledge of the Life Sciences. Experience with scientific peer review, understanding of NASA Space Life Sciences and human physiology is highly desired. Must have good working knowledge of word processing and spreadsheet software.
IDI offers an excellent salary and benefits package including a 401(k) plan. Please forward resumes to: IDI, 400 Virginia Ave, SW,Suite 110, Washington DC 20024. Fax: (202) 863-5210. Email For more information on IDI visit us online. IDI is an Equal Opportunity Employer.
Postdoctoral position to study nucleolar function and RNA transport in yeast and animal cells. Molecular cloning experience and US permanent resident status needed. See EMBO J. 15, 6750; MCB, 16, 5139; JCB, 126, 649. Mail CV and 3 references with phone numbers to A. Tartakoff EOE/AA.
Research Assistant perform assigned research project(s) in field of Molecular Neurobiology in the Anatomy Department. Salary $22,700 pa. MS in biology required. Apply in person or by resume to: Georgia Department of Labor, Job Order #GA 6088248,2636-14 M. L. King, Jr. Drive, Atlanta GA 30311-1605 or the nearest Dept of Labor Field Service Office. EOE/AA.
Postdoc/Research Assistant to assess whether dietary soy components can attenuate Alzheimer's-like memory deficits in animal models. Will involve memory testing and immunochemical and molecular biological analysis of protein risk factors for AD. Contact Dr. H. Kim, Dept. of Pharmacology & Toxicology, U. of Alabama at Birmingham, 1670 University Blvd., Birmingham AL 35294-0019. (205) 934-3880; Fax (205) 934-8240; EOE/AA.
Postdoctoral Position available immediately for PhD with experience in cell and molecular biology or cellular neurobiology. Study the role of a mammalian myosin V in nerve cell function using dilute-lethal (myosin V null) mice in conjunction with video microscopy, motility assays, cell culture, biochemistry and immuno-electron microscopy. Please send or email CV and names of references to: Dr. Paul Bridgman, Washington University School of Medicine, 660 S Euclid Ave., Box 8108, St. Louis, MO 63110. Fax: (314) 747-1150, EOE/AA.
Postdoctoral fellow Annual salary $35,000 (approximate, depends on background). Term: 2 years (1997-1999). Field: Tissue specific transcription factor/developmental biology in osteoblasts, chondrocytes, osteoclasts. Prof. Masaki Noda, Tokyo Medical and Dental University. Phone/Fax: 011-81-3-5280-8066. Email EOE/AA.
Postdoc PhD. Assembly and regulation of intercellular adhesive junctions. Mol. and cell biol. of cadherins and associated proteins in develop. and differentiation. Exper. w/ protein chem., mol. biol., cell culture, EM and LM immunocytochem. desirable. Avail. immed. Start date negot. Send CV, ref. letters, re. interests to: Dr. Kathleen Green Northwestern U. Med. Sch., Dept. Pathology, 303 E. Chicago Ave. Chicago, IL 60611. EOE/AA.
Do You Need a Postdoc, a Research Associate or Fellow? Look to the ASCB first to fill a vacancy by placing your recruitment advertisement in the monthly ASCB Newsletter.
|Dudley Wright 1999 Conference Proposals Sought
The 1997 ASCB/EMBO/H. Dudley Wright conference is almost upon us, and it is time to solicit proposals for the 1999 meeting, which will take place at a to-be-determined site in Europe. Proposals must be submitted by August 1, 1997.
ASCB members who wish to propose a conference topic should contact me using a written communication medium of your choice (please do not call with proposals, as I frequently lose notes taken on phone conversations). Electronic mail, Fax (603) 646-1347, and the US mail (Department of Biological Sciences, Dartmouth College, Hanover, NH 03755) all seem to work well. A phone call (603-646-2377) is appropriate if members just wish to chat informally about possibilities or procedures, etc. Staff support is provided in the ASCB National Office.
The conference receives financial support from the ASCB, EMBO, and the H. Dudley Wright Foundation. Dudley Wright was a farsighted Swiss industrialist who initially supported these meetings with personal funds. On his death, the H. Dudley Wright Foundation generously agreed to continue his personal commitment through the 1990s.
The ASCB/EMBO/H. Dudley Wright conferences are held biennially to foster international collaboration and exchange of ideas on important and timely topics in cell biology. In choosing a topic, the respective committees of the ASCB and EMBO give strong preference to interdisciplinary topics of mutual interest to the membership of the two organizations. It is hoped that such an international focus will mean there is high probability of the conference exerting a significant impact on research in the topic area.
Please note that the Education Committee of the ASCB advises organizers to pay particular attention to the following points governing meetings: every effort possible should be made to maintain a balance between European and North American representation in the choice of speakers, session chairs, and meeting attendees. It is also expected that every effort will be made to maintain a balance between breadth of speaker and participant representation with respect to (i) laboratories and countries, (ii) established and young investigators, and (iii) postdocs and graduate students. Finally, meeting organizers are encouraged to try to ensure appropriate representation by women and minority group members.
If anyone wishes to make general comments concerning the ASCB/EMBO/H. Dudley Wright summer conferences, please contact the Education Committee of the ASCB (9650 Rockville Pike, Bethesda MD 20814-3992) or the Course Committee of EMBO (Postfach 10022.40, Meyerhoffstrasse 1, 6900 Heidelberg 1, Germany). Formal proposals for conference topics should include, but not be limited to, the following: the subject, with some statement as to the interdisciplinary nature and its importance to the international cell biology community, the name of a potential European co-organizer (or a North American co-organizer if the proposer is from Europe), a brief outline of session topics, and a brief list of potential speakers (commitment from whom is not required at the time the topic is proposed). Finally, individuals proposing conference topics must comment as to their willingness to participate in fund raising.
-Roger D. Sloboda, Department of Biological Sciences, Dartmouth College, Hanover, NH 03755; Fax: (603) 646-1347, for the ASCB Education Committee.
Centrosomes and Spindle Pole Bodies
|Education Committee Launches Survey, Regroups Pre-College Activities
Call For Educational Initiatives Forum Speakers
Education Committee Launches Survey, Regroups Pre-College Activities
The Precollege Science Education Subcommittee met to explore continued involvement by the Committee and by the ASCB in precollege science education, and more generally, how a national organization can most effectively be involved in local activity. The Subcommittee recognized that education and research are interdependent and that the Society should therefore continue to play an active role in precollege science education. The Subcommittee plans to develop a position paper to be presented to Council.
A number of suggestions for future Committee projects and activities were made by Committee members Bob Blystone and Malcolm Campbell. Among those that will be pursued are:
Focused display and presentation of commercial classroom education materials. The EdComm will encourage publishers who exhibit at the Annual Meeting to display educational materials directed to all levels of students.
Publication of a Booklet about Shared Positions. This was the topic of an Educational Initiatives Forum and a Careers Lunch table during the 1996 Congress & Meeting and has generated continued interest.
Expansion of the EdComm Web Site.
In conjunction with this discussion, Elizabeth Marincola reported that the ASCB is renovating its Web Site and hopes to have a new home page and an expanded site in place shortly.
Production of a Web resource site led to a discussion of criteria for inclusion of materials and ultimately peer review of science education materials and exercises. The Committee agreed that critical, descriptive, and selective reviews would require the selection of a panel of reviewers to include persons with science expertise and persons with field experience. Committee members Sally Elgin, Mary Lee Ledbetter, Ted Gurney, and Chris Watters will develop suggested criteria for assessment.
The Committee reviewed planned activities for the 1997 Annual Meeting:
The EdComm/MAC Information Booth. The Committee's thanks were expressed to Bob Blystone for his tutorials on use of the Internet for educational activities at the EdComm/MAC Booth in 1995 and 1996. Watters and Gurney will explore the possibility of linking Education Initiatives presentations with scheduled follow-up discussions at the booth.
The 1997 Education Workshop will be on written communication by scientists writing to other scientists: grant proposals, articles for publication, research summaries, and posters. The organizer will be Judith Swan, a science writing teacher at Princeton and co-author of The Science of Scientific Writing.
Educational Initiatives Forum. A wide variety of topics for forum sessions for the 1997 Annual Meeting was suggested by Committee members.
Career Options and Issues Facing Biologists Lunch. Roger Sloboda is working with Sue Wick of the Women in Cell Biology Committee to identify table leaders. The Graduate Student Program has been moved to a later time so that interested graduate students can attend the lunch.
Cell Biology Educational Grant Panels. The panels would present information at the ASCB Annual Meeting about education grants available to scientists; they might be presented during an Educational Initiatives Forum or as part of an EdComm Workshop.
Bob Bloodgood, Malcolm Campbell and Mary Lee Ledbetter will participate in the Coalition for Education in the Life Sciences (CELS) Project Kaleidoscope workshop on Revitalizing Undergraduate Biology in late October. Bloodgood and Elgin serve on the CELS planning committee, which will meet in June.
The Committee reviewed the list of requests made to the ASCB by members of the National Association for Biology Teachers and discussed how to address them.
The Committee thanked Blystone for his Web Site reviews and recognized that they provided a regular educational presence in the ASCB Newsletter. Connie Oliver will explore the possibility of sharing these Web Site reviews with publications of the National Association for Biology Teachers and National Science Teachers Association.
Solomon reported that the Graduate Education Survey has been finalized and will be mailed shortly to a random sample of ASCB members.
The Committee has tentatively agreed to participate in a career survey sponsored by the Commission on Professionals in Science and Technology (CPST) and funded by the NSF. The survey targets first-year graduates of PhD programs.
|New Programs for Research in Pediatric AIDS
The Pediatric AIDS Foundation, in its commitment to fund basic medical research in pediatric HIV/AIDS, announces the availability of funding for One-year Pediatric Research Grants, Two-year Pediatric Research Grants, Two-year Pediatric Scholar Awards, and Pediatric Short-term Scientific Awards.
The Pediatric AIDS Foundation is especially interested in funding creative and innovative research ideas not yet suitable for funding by other agencies (e.g., NIH). All proposals must have direct relevance to pediatric HIV/AIDS and its related issues. The Pediatric AIDS Foundation will accept applications from investigators who are previous Foundation awardees. Established investigators and international applicants at not-for-profit institutions are encouraged to apply. Further, we will consider applications from researchers interested in collaborating with investigators from developing countries. To date, the Pediatric AIDS Foundation has funded all applications that scored in the fundable range during peer review and met the Foundation's scientific criteria for funding, and we will make every effort to continue this commitment. For more information:
Pediatric Aids Foundation
NSF Faculty Early Career Development (CAREER) Program
For information:
NCI Scholars Program
For information:
Professional Opportunities for Women in Research and Education (POWRE)
For information:
|MAC Announces Visiting Professorships
The ASCB Minorities Affairs Committee announces awardees for the Visiting Professorship Program for the summer of 1997. This new program seeks to acquaint professors of science with modern research tools and techniques, help them build a network with community scientists and institutions, and bring the excitement of research science into the classroom. The program is supported by a Minorities Access to Careers Research (MARC) grant from the NIGMS, NIH. The fellowships have been award to:
Pearl R. Fernandes of Morris College, with host scientists Kim E. Creek and Lucia Pirisi of the University of South Carolina School of Medicine, working on the Role of the EGF receptor in human papilomavirus type 16-mediated human cell carcinogenesis in vitro.
Debra Bolen Morrissette of Kennedy-King College, with host scientist Maija I. Mednieks of the University of Illinois at Chicago, working on cAMP-receptor activity in human saliva.
Robert O. Scott of Norfolk State University, with host scientist Miriam D. Rosenthal of Eastern Virginia Medical School, working on Cellular localization of type II secretory phospholipase A2 in human and baboon placenta.
Youvraj R. Sohni of Alabama A&M University, with host scientist Elizabeth J. Kovacs of Loyola University, working on Molecular mediators of lung pathology following burn/infection.
John P.E. Tokeson of Virginia State University, with host scientist T. S. Benedict Yen of the San Francisco Veterans Administration, working on Cloning of a transcription factor involved in ER stress signaling.
To be eligible for the ASCB MAC Visiting Professorship Program, professor and ASCB member scientist were required to plan and submit a research proposal together and submit it with a follow-up plan for the academic year. According to ASCB MAC member and program coordinator Maria Elena Zavala, applications were scored on a variety of variables: the subject of the proposed research and the quality of planned interactions for the professor, plans for ongoing interaction between professor and sponsoring lab after the conclusion of the fellowship, benefit to teaching, the qualifications of researcher and professor, and the potential impact on minorities and schools with high minority enrollment.
|Minorities Affairs Committee Sets Goals
Minorities Affairs Committee Sets Goals
Haynes reviewed the grants which support the MAC's programs for this year. $123,580 from the NIH-MARC, $10,000 from the I&G Foundation, and $31,330 from a supplemental NIH-MARC grant. Haynes challenged the Committee to establish goals for the coming year.
The Committee recognized the need to increase the pool of applicants to MAC programs and to promote minority scientists as role models to the non-scientific community. More publicity of MAC programs within the ASCB membership as well as to the general public were suggested. Committee members committed themselves to increasing their own time devoted to Committee activities. The success of evaluation tools developed for current programs was also reviewed.
On behalf of Maria Elena Zavala, Haynes reported on the Visiting Professorship Program. Five visiting professors will begin their work in the laboratories of ASCB (see page 10) members during the month of June. Of the five awardees, two selected their host scientists from the pool of ASCB members who volunteered to act as hosts; the others identified hosts on their own or were recruited by ASCB members. Haynes noted that although large minority populations reside in the South and Southwest, most of the volunteer hosts are in the Northeast and Midwest. Don Kimmel suggested that visiting professors be asked to explicitly consider how they plan to overcome the problems of time, money, and facilities in the home institution. Curtis Parker noted that instructors at minority institutions frequently were not tenured and received little recognition for participation in programs such as the visiting professorship; the 1998 application will request a letter of support from the visiting professor's dean and a request that these issues be addressed.
The pool of minority applicants for fellowships at the Marine Biological Laboratory Summer Courses has remained constant since 1993; however, enrollment at the MBL of these candidates declined by almost 50% this year. The Committee will target course directors and key contact persons in universities as sources for applicants in 1998. The Committee strongly supports this program. Haynes also committed to seeking support for a similar program at the University of Washington Friday Harbor Laboratories, with cost sharing from Friday Harbor. A tracking tool for participants in summer course programs is being developed.
Sandra Murray has identified ASCB members and former MBL MAC fellows who will participate in the I&G Mentoring Workshop at the MBL on July 12-13. Topics of discussion will include written communication and publishing ("Write It!"), oral presentations ("Say It!"), lifestyles ("Live It!"), and funding ("Fund It!"). George Langford will give the keynote address. Dan Chavez will assist with development of a report or proceedings to be used during the Workshop and to be available after the Workshop. An Internet-based mentoring network is being developed in conjunction with the Workshop.
Dan Friend presented applicants for funding to attend courses at Microscopy & Microanalysis '97, the 1997 Histochemical Society meeting, and the Committee agreed to provide support of $500 to each of eight candidates. The Committee acknowledged that there are many outstanding technical workshops available annually and that therefore it was not a good use of time and resources for the MAC to develop an additional workshop.
Donella Wilson reported that the next meeting of the Minorities Action Committee, an organization of representatives of minority committees from multiple scientific societies, will take place in Bethesda during late June or July. The meeting will address three areas of concern identified at the 1996 meeting: the minority data base, public policy, and the impact of market forces on the hiring of minority PhDs.
The MAC has developed information to be presented on a MAC home page which will link to the ASCB home page. Although the Committee strongly supports the presentation of an electronic minority scientist database, concerns about universal accessability to names and addresses and lack of anonymity were expressed. These issues will be explored in depth at the Minorities Action Committee meeting.
Publicity for MAC activities at the Annual Meeting was discussed and articles for the ASCB Newsletter were assigned. 1997 Annual Meeting activities include: the E. E. Just Lecture, the MAC Poster Session and Awards Luncheon, Special Saturday Session for Young Minority Scientists, and the EdComm-MAC Booth. The MAC will encourage participation at the Annual Meeting High School Program by minority students from Washington, D.C. public schools.
|Grants & Opportunities
New ASCB Howard Hughes Medical Institute Investigators
Grants & Opportunities
The Pediatric AIDS Foundation, in its commitment to fund basic medical research in pediatric HIV/AIDS, announces the availability of funding for One-year Pediatric Research Grants, Two-year Pediatric Research Grants, Two-year Pediatric Scholar Awards, and Pediatric Short-term Scientific Awards.
The Pediatric AIDS Foundation is especially interested in funding creative and innovative research ideas not yet suitable for funding by other agencies (e.g., NIH). All proposals must have direct relevance to pediatric HIV/AIDS and its related issues. The Pediatric AIDS Foundation will accept applications from investigators who are previous Foundation awardees. Established investigators and international applicants at not-for-profit institutions are encouraged to apply. Further, we will consider applications from researchers interested in collaborating with investigators from developing countries. To date, the Pediatric AIDS Foundation has funded all applications that scored in the fundable range during peer review and met the Foundation's scientific criteria for funding, and we will make every effort to continue this commitment. For more information:
Pediatric Aids Foundation
NSF Faculty Early Career Development (CAREER) Program
For information:
NCI Scholars Program
For information:
Division of Cancer Treatment,
Professional Opportunities for Women in Research and Education (POWRE)
For information:
Post-Doctoral Fellowship in Cell Biology


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The Tippmann TCR should be out in June. It has multiple air sources and accepts TiPX or Zetamag Magazines. Read more . . .
New Releases
Virtue Vio Goggles Will Be Arriving Monday!
Our first shipment of Virtue Vio goggles should be landing here on Monday!
New Tippmann Crossover XVR Colors – Blue and Bronze
Tippmann has just released some new colors of the popular Crossover XVR marker. They're going to be a limited edition run so when they're gone they're gone. This is a great chance to upgrade to the top of the line Tippmann marker and get one that'll be unique on the field too. The two new colors are Blue and Bronze. The color will be on the body, barrel and ASA with the grips and other accents colored black. This makes for a nicely balanced 2 tone paintball gun.
We should have both colors arriving at our TippmannParts warehouse this week or early next so we're starting to take pre-orders for the new XVRs now.
Two of the old colors are being discontinued. The Red and Titanium are officially sold out from Tippmann. At the time of this post we have only 1 left of each of those colors so if you had your heart set on one of them then now's the time to pull that trigger.
Related Links
New Colors of Paracord In Stock
New TECHT Clear/Smoke Cyclone Feed Housing
TECHT Paintball has just released their new EZ View Clear / Smoke Feeder Housing for Tippmann Cyclone Feeds. It includes the housing and bottom plate (no internals) so you can see if you have paint left and diagnose feeder problems with just a glance. More info on the housing product page. They should be shipping out to us on Friday and here by Tuesday ready to ship to you!
Tippmann Crossover
The brand new Tippmann Crossover is the latest addition to Tippmann's long roster of markers. However the Crossover is quite different from anything Tippmann has put out in the past.
The Crossover is ultra light weighing just over 2 pounds, operates under 300psi for a smoother operation that's easier on internals and paint, comes with break-beam eyes, clamping feedneck, adjustable double-trigger, gas-thru grip, and a mechanical and electronic safety.
The most talked about feature is the Flex Valve technology already seen in the Tippmann Phenom. The Flex Valve allows the used to switch from electronic operation to mechanical operation at the flip of a switch. Want to save battery life during a long scenarioe? The Crossover has you covered. Battery finally dead? No problem. Want to save paint? Done.
The Crossover boasts many unique features and is sure to make many waves in the paintball community for a good time to come.
Tippmann Crossover – Brand New For 2012
Tippmann has finally brought forth what so many have been asking for all these years, a simplified lightweight marker with all the reliability of the Tippmann brand and all the features of their previous models in one well-rounded package.
The Tippmann Crossover is brimming with features including integrated break beam anti-chop eyes, low pressure operation under 300 PSI, integrated grip through gasline with the option to convert to a front regulator, magnetic Hall-Effect trigger switch, multiple adjustable firing modes, including semi-auto, auto-response, 3-shot burst, PSP, NPPL and Millennium, adjustable clamping feedneck with vertical feed, and A-5/X-7 threads.
Although the most exciting feature for players is the Tippmann patented FlexValve technology integrated from the Phenom and now present in the Crossover. The ability to run from electronic to mechanical operation in the middle of a game will be a fantastic feature with the added benefits of the low recoil, low pressure features of the FlexValve. The Crossover is sure to take the game to new heights and new possibilities, don't be the last to take advantage of this amazing marker.
Trinity AR-15 Style Magazines – New Colors
– Olive"] – Dark Earth"]Trinity has released a new set of AR-15 magazines for the Tippmann A-5 Paintball Gun. They're available in black, dark earth, or olive. This particular set of magazines works only on the 2011 A5 Mechanical paintball guns.
J & J Performance Releases New Commando Barrel
"]"]The new Commando barrels from J&J have a removable tip so you can customize the look of your barrel. The come stock with an M16 muzzle break but you can also put on the Sarge Muzzle Break or an adapter for the Apex barrel tips. Available for Tippmann A5's and Tippmann 98 Custom.
Angled Foregrips for Tactical Paintball Guns
The Trinity Angled Foregrip (this link is to the black one, the also come in dark earth color and dark ranger green) is a grip that mounts to any picatinny style rail. Until now, the only option was the vertical handle grip. The angled grip has been found to create a steadier aim when holding. Each of these angled grips come with an optional plate that will insert a finger ridge, should you desire it. Note that if you have an Alpha Black (or any m16 style shroud) you will need to add the Alpha Black Rail to mount the grip.
New Trinity X7 Fury Stock
New from Trinity is the X7 Phenom Fury Stock, and is the latest addition to our collection of X7 shoulder stocks. This 6 position tactical stock comes in three colors; black, sand, and olive. This stock design is a more updated and current design which is used on real assault rifles. This stock design is known to be more stable and locks down so that it does not wobble. This will create the cutting edge elite look for your tactical paintball marker.
Rotor Paintball Loaders – New DYE 2012 Colors
The DYE Rotor paintball loaders are some of the most popular hoppers in paintball. They feed super fast and are simple to use. One button operation. On and Off. They don't require any programming or fiddling. Just turn them on to use and off when you're done.
Add to this a tool free breakdown for easy cleaning and battery replacement and you've got our favorite high end hopper. Dye has now released new colors for 2012.
What is the Tacamo Handguard Adapter?
Many web searchers have found this paintball mod and wondered what it was for. The Tacamo Handguard Adapter will attach to any paintball gun that uses model 98 barrel threads and allow the gun to use the shroud from the US Army Alpha Black. This device was originally made for the Tacamo Magazine feed kit. Since the magazine kit is the same for the Alpha Black and the Tippmann 98 Custom, this block needed to be added to the Alpha Black version of the kit so the front shroud would still work. An added bonus of the adapter is that it has a small section of 1″ rail on the top for mounting gear.
New OU812 Paintball Goggles have Super Detailed Graphics
The new OU812 paintball masks from Save Phace are using a new graphic transfer technology called water immersion. This allows a much greater resolution on their graphics. Now for most paintball goggle companies that wouldn't be a big deal but Save Phace has some really good artists that produce very detailed and exciting designs. This higher resolution lets the artists show off their talents even more and you get the benefit by getting to wear a true piece of artwork while you shoot people.
How sophisticated!
Turn your 98 Custom in to a Magazine Fed MilSim Tactical Paintball Gun
"]Surely you've heard about the new magazine fed conversion kits by Tacamo. If not well then read on.
This conversion kit includes everything you need to convert a Tippmann 98 Custom from a regular hopper fed paintball gun to a magazine fed paintball gun. If you've looked at how the feed port is integrated in to the body then you can tell that this is no small feat. The kit includes a new body for the gun that puts the feed port under the gun instead of on the side. It also has the magazine mount and a 20 round magazine too. You can even upgrade your magazine to a large Box Magazine that mounts to to the same position underneath of the gun. The Nautilus Box magazine holds up to 200 rounds.
Lapco TPX Front Block with Rail Now Available in Three Colors
Lapco has released 2 new colors of their TPX front block.FDE, or Flat Dark Earth, is kind of an olive drab green color. Now it's just the picatinny rail on top that is this new color. The main front block body is still dust black aluminum.
The DS TPX Front Block Mod, or Desert Sand,has a light brown rail on top.
Both colored rails are made out of a military grade composite that won't deform in high humidity or extreme (high or low) temperatures. So once you get your sight or scope sighted in, it's going to stay in position.
The Tippman TiPX was formerly called the TPX by Tippmann. Regardless of what your gun says on the side (TPX or TiPX) this will be a great mod. Lapco's exacting standard ensure a perfect fit to your paintball pistol.
Tippmann X7 Phenom Assault Limited Edition Paintball Gun – Just Released!
Tippmann has just released a new version of their top rated X7 Phenom paintball marker. This is the Limited Edition Assault Phenom. It includes 5 of the most popular Tippmann Tactical upgrades for a a custom mil-sim look. the will be one of the best guns for woodsball that you can get.
The tactical stock is both a folding stock and a collapsible stock at the same time. Two folding tactical sights let you easily acquire your target and blast them away with one of five firing modes.
This full auto paintball gun has an electronic (egrip) trigger but also other modes like semi-auto, auto-response, and 3-shot burst. Tippmann has even thrown in an X7 magazine and shroud. All of these Tippmann X7 Mods are factory installed and test so you get a custom gun without the work of customizing your own gun.
These will be in stock at TippmannParts.com on Monday the 12th.
Three Paintball Loading Accessories to Make Your Life Easier
Allen Paintball Products has a set of 3 items that will make loading up your paintballs for a long day of play a snap.
The first things is the Jerry Can Paintball container. This large container holds over 1000 paintballs. An air tight lid keeps them fresh all day long. Now you don't have to worry about your paint getting swollen and sticky because of high humidity. You also don't spill them all over the place when you pick up that bag of balls that you were sure was tied shut.
From you new Jerry Can container, you can pour directly in to your pods but usually this takes 2 hands if you're lucky and even then you end up spilling at least a few paintballs on the ground. Now introducing the Pod Funnel and Pod Pal pod holder. The Pod pal is a slick little tripod device that sets on a table or any flatish surface and holds your pod securely in place. Kind of like a 3rd hand.
The funnel s what it says it is. Just drop this funnel in the top of your pod and you now have a doubly large opening to pour in to. If you miss that then you might as well call it a day.
Each of these paintball accessories will save you time and paintballs. So hurry up and get some from TippmannParts.com so you can hurry up and play.
Engler Custom Paintball Guns now available
We now carry Engler Custom Paintball Guns!
These paintball guns are modified to look and feel like real historic military firearms. They are great for anyone wanting to play in a historic themed paintball battle.
Most of these are modified Tippmann X7 Phenoms. On our website, they currently reside here: Engler Custom Paintball Guns.
A few of these guns are made with Tippmann 98 Customs as well.
These guns are custom made for each order, many use real firearms parts. It is possible that they are available to ship on short notice, but you should be prepared to wait about 4 weeks for delivery. (It will be worth the wait).
Check them out
JT Spectra Proflex Goggles Available in Limited Edition Colors
JT has recently released a new color of their popular Spectra Proflex line. The Desert Tan and Black paintball face mask is a perfect match for lots of different camo patterns. If you're not already familiar with the Proflex line then you should be. They use the Flex7 Goggle Frame and Mask but instead of having hard plastic ear pieces they have a smaller and softer earpiece. So YES, there is less protection here. But you can hear better with these goggles because there's less bulky goggle blocking the way to your ears. You also get a tactical advantage that balls are less likely to break on these soft ears. More bounces mean you get to stay in the game longer. The smaller foam ear pieces also make the goggle a bit lighter. The Flex7 and ProFlex include the soft rubber mouth guard too. You'll definitely feel the paint hit you on the cheeks and mouth but you get lots of bounces off this area. So if you like to get up in the fight and need that extra advantage while looking good at the same time then you need to take a look at the se new limited edition colors. They also come in Olive and Lime Green.

subset: commoncrawl


text:
Keeping the garden tidy requires a few deft moves with the right tools, and, time and again over the seasons, shrub rakes are... Read more »
Entire books have been written on the science of making compost, but it isn't as hard as people think. In five easy steps, you... Read more »
Weeding, pruning, and raking all make a huge difference in the appearance of a garden, but, to finish the job, you have to rou... Read more »
The Fiskars® aluminum shrub rake features a slim head with uniquely tapered tines that are perfect for reaching into tight spac... Read more »
Our Eco Bin Composter features an easy-to-assemble, easy-to-use design that can simplify and speed the composting process. It i... Read more »
Our HardShell® Kangaroo® Gardening Container is perfect for all your outdoor cleanup needs — whether you're gathering yard and... Read more »
Are school fundraiser ideas keeping you up at night? A unique handmade art piece that represents your school is sure to be a p... Read more »
Creating beautiful and personal touches does not have to be difficult, especially when you have great designs to work with! Read more »
Recycle and give a new life to some of your old T-shirts Read more »
Teresa Collins is a top craft celebrity who has been featured numerous times on My Craft Channel, HSN, QVC and DIY network, wel... Read more »
Teresa Collins is a top craft celebrity who has been featured numerous times on My Craft Channel, HSN, QVC and DIY network, wel... Read more »
Our unique Tag Maker with Built-in Eyelet Setter features an innovative design that makes it easy to create tags perfect for gi... Read more »
By creating a few simple tags, you won't be caught at the fabric store not knowing what fabrics or yardage you have in your st... Read more »
A brocade drawstring pouch can be a beautiful and luxurious accessory or gift. Read more »
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Perfect for a wide range of sewing and quilting tasks, our Amplify® RazorEdge™ Serrated Fabric Shears sense blade separation an... Read more »
Perfect for a wide range of sewing and quilting tasks, our Amplify® RazorEdge™ Fabric Shears sense blade separation and force t... Read more »
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Are school fundraiser ideas keeping you up at night? A unique handmade art piece that represents your school is sure to be a p... Read more »
Try some new punches out and make some cards to celebrate World Card Making Day! Read more »
A personalized Duck Tape® crown is quick and easy to make with your Fiskars® Duck® Edition Scissors. It is a fun way to cele... Read more »
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Transform a basic jacket into something personal and unique. Read more »
Create a simple reusable calendar to plan all of your back to school activities. Read more »
Creating a miniature collage with your Fiskars® Duck® Edition Scissors is a great way to use up any last bits of Duck Tape® yo... Read more »
Designed for long, easy cuts down strips of Duck® Tape, our Duck® Edition Scissors feature a non-stick blade coating that preve... Read more »
Designed for all-purpose cutting through a range of craft materials that incorporate glue, tape and other sticky adhesives, our... Read more »
Designed for tight, precise cuts through a range of craft materials that incorporate glue, tape and other sticky adhesives, our... Read more »
Add personality to your drinkware with this DIY coffee mug.
The AdvantEdge™ Punch System features slide-and-lock technology that makes punching perfectly aligned borders easier than ever.
1. Punch both scalloped circles and regular circles, in graduating sizes, making sure that the colors of each layer contrast with one another. (Circle Lever Punch 4XL, Pretty Scallops Lever Punch 4XL, Circle Lever Punch 3XL, Pretty Scallops Lever Punch XXL, Round 'N Round Squeeze Punch XL and Round 'N Round Squeeze Punch Large.) If you don't have these exact sizes, get creative in layering the shapes that you do have on hand.
2. Adhere the layers together, leaving adhesive off of the scalloped edges.
3. Use your fingers to curl up the edges of the scallops to add dimension. If you want to add additional dimension to your turkey use foam dimensional tape between the layers of punched pieces.
4. Embellish the smallest circle to resemble a face. Using Walnut Stain Distress Stain along the edges of the punched shape, and then embellished the circle with two brown brads for the eyes, an orange cardstock triangle for the beak and two dots of Worn Lipstick Distress Stain for some rosy cheeks.
5. To apply the Worn Lipstick Distress Stain, simply pressed my fingertip onto the wet applicator and rubbed it into the cardstock. You can also use a cotton swab to apply the stain. If you don't have these stains in your crafting supply, inexpensive watercolor paints are a great alternative.
6. Finish adhering the layers, and then add additional embellishments to bring a little more life to your turkey. Wooden or wood grain embellishments and baker's twine make great additions. Set this aside to prep your card base that your turkey will reside upon.
7. You can create a fun sentiment banner for your card with some additional punched shapes. Then, further embellish the circles with some tiny alphabet stickers to spell out the word 'thanks'.
8. prepare and embellish your card adding layers of washi tape, small cuts of cardstock and some torn adhesive-backed cork. Before adding on the turkey, add a sentiment banner and a few flat-backed pearls.
Once that's all done, it's time for your turkey to find it's home right there in the center before sending him off to express your gratitude to those who have touched your life.
Happy season of thankfulness!
Patterned Paper
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Foam Dimensional Tape
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Bid Writer
Bid Writer required for a private company based just outside Nottingham City Centre. The role is to work within a Construction Company who also specialise within Facilities maintenance, New Build and Installation.
The role requires you to be from the same sector, this is essential. You'll be required to assist and manage the written and editorial aspects of the proposal development process.
You will communicate requirements , deadlines and expectations to key stakeholders and the proposal team.
You will take full ownership of content, produced computer generated graphics and edit the text produced by other areas of the business.
You will need to be degree educated- posses excellent technical writing and communication skills. The ability to write complex and technical concepts in easy to understand ways and convey ideas graphically.
We require you to have industry sector knowledge as you will be need to tailor the documents to specific audiences and generate business for their company.Hays Specialist Recruitment Limited acts as an employment agency for permanent recruitment and employment business for the supply of temporary workers. By applying for this job you accept the T&C's, Privacy Policy and Disclaimers which can be found at hays.co.uk
Job Type : Permanent
Location : Nottingham
Salary : £20k - £25k pa
Date Advertised : 26 Nov 2012
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West Point alum Donna McAleer was at her Utah home last week when she got a call asking if she'd "seen the latest."
A male Army sergeant, a friend told her, had just been charged with secretly photographing and videotaping at least a dozen female cadets at McAleer's alma mater.
Many of the women were naked; some images were taken in a bathroom at the U.S. Military Academy in New York. The revelations followed a rash of recent incidents, among them stunning reports that at least three ranking male officers overseeing military sexual assault prevention programs have themselves been charged in the past month with crimes ranging from sexual battery to stalking.
"How many of these stories are we going to hear?" asks McAleer, a field admissions officer for the academy. "I want to be able to, with confidence, encourage people — daughters and sons — to serve their country."
As the nation prepares to honor the war dead this Memorial Day weekend, a seeming epidemic of sexual assault and abuse reports has severely shaken that confidence.
A new Pentagon study estimates that 26,000 people in the Armed Forces were sexually assaulted last year. It's not entirely clear top brass understands the scope of the crisis: Air Force Chief of Staff Gen. Mark Welsh suggested in recent Senate testimony that the spike in reports of sexual assaults in the military could be blamed on the "hook up mentality" of the country's young people.
Welsh has since apologized, but not before fanning outrage that's been building on Capitol Hill and beyond over the military's long failure to repair a system that has placed service members, especially women, in more danger of sexual assault than battlefield injury.
"We have relied on the chain of command to deal with this issue, and the chain of command has failed for decades," says retired U.S. Army Maj. Gen. Dennis Laich. "America gives us their sons and daughters, and we've failed to discharge the responsibility to take care of them."
An Action Imperative
It's been more than two decades since the sexual-assault-and-hallway-grope-a-thon at the Navy's "Tailhook" aviators' convention in Las Vegas, which led to the resignation of the Navy secretary.
It's been a decade since the lid was blown off a rape and sexual assault scandal at the U.S. Air Force Academy in Colorado Springs, where the school's top four officials were removed.
It's been a year since investigators at Lackland Air Force Base in San Antonio found evidence that a dozen instructors had engaged in "sexual misconduct," including rape, leading to the conviction of at least nine of them.
So it should come as no surprise that parents, with more and more frequency, are asking recruiters if their daughters, and sons, will be safe in the military — a question prompted not by roadside bombs, but assault statistics.
McAleer, the West Point recruiter and author of Porcelain on Steel, a collection of profiles of accomplished female academy graduates, says the answer is no, as long as the military continues to rely on its chain-of-command system to hear, investigate and prosecute assault claims from the ranks.
"It's delusional to think we can do this over and over and get a different result," she says, referring to statistics that show those in the chain of command are the perpetrators in a quarter of cases of alleged assault.
She, and others, including New York Sen. Kirsten Gillibrand, a member of the Senate's Armed Services Committee, argue that the military should create a separate legal process to deal with sexual assault claims.
Gillibrand, a Democrat, has sponsored legislation to do just that. A separate bill proposed by Sen. Claire McCaskill, a Missouri Democrat and a member of the Armed Services Committee, would not require the new legal structure, which she argues the Pentagon would work to block.
Her legislation focuses on measures that would remove commanders' ability to overturn military sexual assault convictions, and require dismissal or a dishonorable discharge for service members found guilty of rape or sexual assault.
Similar legislation has also been proposed in the House, and, as in the Senate, is backed by members of both parties in efforts led by women.
Commanders' authority to overturn convictions came under fire earlier this year when it was revealed that Air Force Lt. Gen. Craig Franklin reversed the aggravated sexual assault conviction of Lt. Col. James Wilkerson and then reassigned him as safety chief at a base in Tucson, Ariz.
Wilkerson had been convicted of assaulting a civilian contractor while at Aviano Air Force Base in Italy.
McCaskill has held up the nomination of another top Air Force commander and former astronaut, Lt. Gen. Susan Helms, to a NASA post because she overturned the aggravated sexual assault jury conviction of an Air Force captain whose victim was a female lieutenant.
Turning Point?
The military, like any organization, has long focused on protecting the institution. And it has relied on the traditional chain of command to deal with the sexual assault issue.
"No one wants to take bad news to their boss," said Laich, the retired major general who now works in a program at Ohio Dominican University to encourage veterans to use their college benefits.
"You have an institution that consciously or unconsciously has given the message that they don't want to hear that bad news," he says.
Advocates for change say that the bad news can no longer be easily hidden, however. Information networks, the 2012 Academy Award-nominated documentary The Invisible War about sexual abuse in the military, and the record number of women serving on congressional armed services committees, they argue, have put the issue before the public in a way never before seen.
"There are 230,000 women serving in the military. There's a documentary like The Invisible War. There are lawsuits, and there's a technology-driven global economy that allows information to be disseminated," says McAleer. "All of that coming together has brought this front and center."
Susan Burke, a Washington lawyer who represents service members, including those featured in the documentary, says several military assault cases are pending in civilian court.
She notes, however, that winning outside of the military justice system is "an uphill battle."
"Supreme Court jurisprudence is very protective of the military," she says. "The judiciary is reluctant to hear cases brought by service members."
Military Takes Action
In response to the crisis, the military has begun programs to reduce sexual assault crimes and provide victim support, and has taken steps to strengthen sexual assault investigations and prosecutions.
Last year, then-Secretary of Defense Leon Panetta, after seeing The Invisible War, required that sexual assaults be reported to a higher level commander; he also established special victims units in each branch of the military.
And the Obama administration recently held a bipartisan meeting of congressional women serving on the House and Senate armed services committees.
Having more women on the committees "has made a tremendous difference," says Tanya Biank, author of Undaunted: The Real Story of America's Servicewomen in Today's Military. "They are the ones who are leading the way and bringing it to attention on a national level."
Biank and others say they see sexual assault as an issue that compromises not only recruitment, but readiness and national security, particularly given the growing number of women in the military.
The fight to change the ways of the military, by altering through congressional action the Uniform Code of Military Justice, has really only just begun in earnest.
What Laich and other advocates say they want to see is the military expand its focus from prevention to aggressive prosecution.
"We may have to err on the side of being perhaps overly harsh with those who are found to be guilty of these kinds of infractions," he says. "There's a tendency to give the benefit of the doubt to the perpetrator, and that has to be turned on its head."
"These aren't just social issues, these are real national security issues that affect our ability to man the force," Laich says. "When you have data that says a female service member in Afghanistan is more likely to be raped by a fellow service man than killed by the Taliban that tells you something about where we are on this issue."


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Scholars in Service to Pennsylvania is an initiative at Misericordia University that recognizes, trains, and supports students who are civically engaged. Students apply for a small number of positions available each year. Selected students will pledge to complete 300 or 450 hours of service in one calendar year, and, in exchange for that commitment, will receive leadership, training, and support from the staff and fellow Scholars, and participate in ongoing supervision and reflection activities.
The bulk of the service work will be completed in a community organization: 8 – 10 hours per week and attend monthly supervision/reflection sessions with all enrolled Scholars.
Scholars in Service to Pennsylvania is an AmeriCorps Education Award Only program. Participating students will enroll as AmeriCorps members on a part-time basis. Students who enroll in this program and successfully complete the 300/450 hours of service, will receive an estimated AmeriCorps Ed-Only Award of $1208.00* for 300 hours and $1510.00* for 450 hours. The award can be used to pay for any legitimate educational expenses at the current undergraduate institution or to pay for future educational expenses. It can also be used to pay for existing federal educational loans. (Please note that the Ed Award is taxable.)
* these figures are based on the projected maximum Pell grant for 2012-2013. Final Education Award amount will be confirmed prior to enrollment in AmeriCorps.
An applicant of the Scholars in Service program must:
The Scholars in Service to Pennsylvania program is intrinsically beneficial to students as it fosters an atmosphere of service and of leadership. In particular, the program seeks to develop practical skills amongst its Scholars through a combination of direct service, training and reflection, volunteer recruitment and leadership development. Ideally, Scholars will commit to volunteering with one primary community organization or project throughout the school year. Students may work with a second organization during the summer months.
The Campus Ministry Office values diversity and strives to include students from diverse racial, ethnic, cultural, and socioeconomic backgrounds in this program.
Students will choose from one of the three models following:
Responsibilities for Students
Other suggested activities
Click here to download the student SISPA application form


text: > Belfiore Oh, come on please. Unless Erika submits her version, I say trash this dance. **All the more reason to discuss WHY it should or shouldn't be included and to see if there are regional variations of said dance. Now you showed us Prexonera a long time ago (over three years at a Namron practice) and I remember that being a fun dance! I wish we could do this more often, so if we come down there for a ball some time and have live musicans (not the keyboard music) we should do this again. ** I agree. I always need helping matching the music since I haven't done it enough yet, but it was a blast at KWDSIII. I think we should add Spero to the manual too! **Never done it, but I've done Salterello Tedesco in several dances with Philip. Craig, care to weigh in on this one? What happened to Il Gratioso? **I believe that Lowrie is continuing to fine-tune the write-up on this one. Oh, buy the way I asked Lady Helene to add Farandole to the Monsters and Myth ball dance list **Sounds great! Sebastian will be so pleased. Now I just have to convince him that he wants to go to the event. ;-) Capricia _______________________________________________ Ansteorra-dancers mailing list Ansteorra-dancers at ansteorra.org http://www.ansteorra.org/mailman/listinfo/ansteorra-dancers


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A Study of MDX-1106 in Patients With Selected Refractory or Relapsed Malignancies (MDX1106-01)
This study has been completed.
Bristol-Myers Squibb
Information provided by:
Bristol-Myers Squibb
ClinicalTrials.gov Identifier:
First received: February 27, 2007
Last updated: April 22, 2010
Last verified: April 2010
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Detailed Description:
To determine the safety and tolerability of MDX-1106 when administered to patients with advanced non-small cell lung cancer, colorectal cancer, malignant melanoma, renal clear cell cancer or hormone refractory prostate cancer
Carcinoma, Non-Small-Cell Lung
Colorectal Cancer
Malignant Melanoma
Renal Cancer
Prostate Cancer
Biological: MDX-1106
Phase 1
|Study Type:
|Study Design:
|Allocation: Non-Randomized
Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Phase 1, Open Label, Dose-escalation, Safety and Pharmacokinetic Study of MDX-1106 in Patients With Selected or Relapsed Malignancies
Resource links provided by NLM:
MedlinePlus related topics: Cancer Colorectal Cancer Kidney Cancer Lung Cancer Melanoma Prostate CancerU.S. FDA Resources
Further study details as provided by Bristol-Myers Squibb:
Primary Outcome Measures:
- incidence and severity of treatment-emergent adverse events [ Time Frame: if they occur, they will be monitored through resolution of the event ] [ Designated as safety issue: Yes ]
Secondary Outcome Measures:
- Clinical laboratory tests [ Time Frame: study duration ] [ Designated as safety issue: No ]
- physical examination [ Time Frame: screening ] [ Designated as safety issue: No ]
- electrocardiograms [ Time Frame: study completion ] [ Designated as safety issue: No ]
- vital sign measurements [ Time Frame: study duration - each visit ] [ Designated as safety issue: No ]
|Study Start Date:
|August 2006
|Study Completion Date:
|November 2009
|Primary Completion Date:
|November 2009 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: 1
patients will receive active MDX-1106 drug
Biological: MDX-1106
patients will receive a single dose of MDX-1106 at 0.3, 1.0, 3.0 or 10 mg/kg as a 90 minute infusion.
Other Name: MDX-1106
Detailed Description:
Six patients will be enrolled at each dose level of 0.3, 1.0, 3.0 and 10mg/kg; the remaining 10 to 15 patients may subsequently be enrolled at a dose at or below the maximum tolerated dose (MTD) during the dose-escalation portion of the study. Patients who respond may receive additional doses of drug.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Relapsed/refractory non-small cell lung cancer, colorectal adenocarcinoma, malignant melanoma, renal (clear) cell carcinoma, or hormone-refractory prostate adenocarcinoma
- Prior treatment must have been completed at least 4 weeks prior to enrollment
- No untreated primary or metastatic brain or meningeal tumors
- ECOG PS 0 or 1
- Meet all screening laboratory values
Exclusion Criteria:
- History of severe hypersensitivity reactions to other monoclonal antibodies
- No active autoimmune disease or a documented history of autoimmune disease
- No prior therapy with an anti-PD-1 or anti-CTLA-4 antibody
- No active infection
- No concomitant immunosuppressive medications
Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00441337
Please refer to this study by its ClinicalTrials.gov identifier: NCT00441337
|United States, Maryland
|Johns Hopkins Unv., School of Medicine
|Baltimore, Maryland, United States, 21231
|United States, Michigan
|Henry Ford Health System
|Detroit, Michigan, United States, 48202
|United States, Missouri
|Washington University School of Medicine - Barnes Jewish Hospital
|St. Louis, Missouri, United States, 63110
|United States, North Carolina
|Carolina BioOncology Institute, PLLC
|Huntersville, North Carolina, United States, 28078
Sponsors and Collaborators
Bristol-Myers Squibb
|Study Director:
|Bristol-Myers Squibb
|Bristol-Myers Squibb
More Information
Additional Information:
No publications provided by Bristol-Myers Squibb
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Keywords provided by Bristol-Myers Squibb:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on November 27, 2014
Additional Information:
No publications provided by Bristol-Myers Squibb
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|Study Director, Bristol-Myers Squibb
|ClinicalTrials.gov Identifier:
|NCT00441337 History of Changes
|Other Study ID Numbers:
|Study First Received:
|February 27, 2007
|Last Updated:
|April 22, 2010
|Health Authority:
|United States: Food and Drug Administration
Keywords provided by Bristol-Myers Squibb:
non small cell lung cancer
lung cancer
colorectal cancer
malignant melanoma
renal cancer
renal carcinoma
prostate cancer
prostate adenocarcinoma
Recurrent or treatment refractory malignancies
Additional relevant MeSH terms:
Carcinoma, Non-Small-Cell Lung
Carcinoma, Renal Cell
Colorectal Neoplasms
Kidney Neoplasms
Prostatic Neoplasms
Bronchial Neoplasms
Carcinoma, Bronchogenic
Colonic Diseases
Digestive System Diseases
Digestive System Neoplasms
Gastrointestinal Diseases
Gastrointestinal Neoplasms
Genital Diseases, Male
Genital Neoplasms, Male
Intestinal Diseases
Intestinal Neoplasms
Kidney Diseases
Lung Diseases
Lung Neoplasms
Neoplasms by Histologic Type
Neoplasms by Site
Neoplasms, Germ Cell and Embryonal
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neuroectodermal Tumors
Neuroendocrine Tumors
ClinicalTrials.gov processed this record on November 27, 2014


text:
A Bell 222 helicopter, N222LF, operated by C J Systems Aviation Group, was substantially damaged when during the engine start at the Casper Medical Center, Casper, Wyoming; a wind gust forced the main rotor blade into the left vertical stabilizer fin and tail boom. The positioning flight was being conducted under the provisions of Title 14 CFR Part 91. The commercial pilot on board was not injured. Visual meteorological conditions prevailed at the time of accident. The wind conditions At Natrona County Airport, 6 miles west of the hospital were reported as out of the west at 30 knots.
The National Transportation Safety Board determines the probable cause(s) of this accident to be:
Index for Nov2007 | Index of months


text:
Home > Gaming > Nintendo Wii > Accessories
This listing closed and did not sell. The item has been relisted.
WII Remote Controller Motion Plus+Silicon Case#W
- No reserve
- Closed: Sat 7 Jul 2012, 8:45 pm
The Wii MotionPlus is an expansion device for the Wii Remote video game controller that allows it to more accurately capture complex motion. Simple, intuitive, easy to use: connect the Wii MotionPlus accessory to your Wii Remote controller to increase accuracy and enhance play control on compatible games. Wii MotionPlus contains additional sensors that make the Wii Remote respond to the slightest movement, motion, or twist of the wrist.
1x Wii MotionPlus
1x Silicon Case for Remote
3 Month NZ warranty
1x Wii MotionPlus
1x Silicon Case for Remote
3 Month NZ warranty
Shipping details
- $5.00 Nationwide Couriers
- $8.00 Rural Nationwide Courier
- $4.00 Local Courier within Wellington
- $0.00 Pickup, please see our profile for times
- Seller allows pick-ups
- Seller location: Lower Hutt City, Wellington, NZ
Payment details
- NZ bank deposit
- Cash
About the seller
wholesaleco. Member is In Trade
- 99.4% positive feedback
- Member since Mar 2006
Closes: Sat 7 Jul, 8:45 pm. 2012


text:
Sanity is madness put to good use. – George Santayana
According to a news story published in the Daily Mail, a new book written by a psychiatrist says that women talk more than men, and that we are verbal junkies. In her book, "The Female Mind," Dr. Luan Brizendine writes that women talk three times more than men, and that the act of talking floods our brains with chemicals that give us a rush similar to that felt by heroin addicts when they are high.
Look at these nurses standing by the Coke machine. When I first looked at this ad, I thought these ladies were just getting their caffeine fix for the day, but according to the good psychiatrist, they are getting a different kind of fix as well. During my long career as a nurse, I can attest to the fact that nurses love talking to each other about every subject known to mankind. But are we truly junkies? Let's look at the facts.
People who are addicts share many common characteristics. Addicts are moody and they have huge appetites, especially for sweets. These characteristics are also prevalent among nurses. We crave chocolate, pizza, and Chinese takeout food when we are running our butts off at work, and we get moody when we work double shifts without taking a break. Ask anyone who works with nurses and they will tell you that you are risking your life if you take the last piece of pizza or the last doughnut sitting at the nurses station without permission. And yes, we love to talk. We talk about everything. There is no subject that is off limits, and it's hard for our male colleagues to get a word in edgewise. Maybe that's why doctors give phone orders. See the doctor on the book cover? He's getting ready to call in phone orders because he knows that the nurse talking to him can't talk to anyone else while she's on the phone. He's a smart doctor.
If nurses are junkies because we like to talk, it's time to start Talkers Anonymous. Hello, my name is Mother Jones, RN and I'm a blaboholic.
November 28th, 2006 at 9:59 pm
I'm an addict and I dont want to ever enter recovery:)
Deacon Barry
November 29th, 2006 at 8:47 am
Nope, don't have a problem getting my words in. Mind you, when the conversation moves round to reality television, you might.. just…. see…….my……….
November 29th, 2006 at 9:10 am
As a male, married for a very very VERY long time, I have tons of theories and opinions about this one. As one who hopes to make it another 5 or 10 years before one of us expires, I know when to keep my mouth and my keyboard shut.
November 29th, 2006 at 12:32 pm
As a nurse who works primarily with other FEMALE nurses (and an increasingly high ratio of female docs), I think the theory is right on: have you ever been at the main desk on L&D at change of shift? Holy crow! My ears are still ringing…
The Curmudgeon
November 29th, 2006 at 1:12 pm
Blabaholic and blogaholic both?
November 29th, 2006 at 3:29 pm
As a mother of a 6 year old girl all I can say is this is so true!
She literally never stops talking. It drives me nuts and I'm a talker! I have the most verbal child in creation. I've had people say to me, she's a talker isn't she and all I can do is sigh in resignation. At least now I know there's a reason for it.
November 29th, 2006 at 8:51 pm
Try the most verbal 3 year old (almost) twins in existence! I thought twins had a language delay?????
I am both a blab-a-holic and now a blog-o-holic. I'm with greensunflower – no recovery for me just more conversations!
Bohemian Road Nurse...
November 29th, 2006 at 11:32 pm
I'm a blaboholic, too!
November 30th, 2006 at 12:23 am
talkaholic me? ohhhh yes. But men are the worst gossips. Get a bunch of old men in one of these little country stores and you'll see what I mean LOL!
Michael Clifford, L. Ac.
November 30th, 2006 at 10:30 am
And all my life I just thought I was introspective. Now I learn that at least I am not addicted to neurochemicals. But, truth be told, after teaching for four hours I really DON'T WANT TO TALK anymore. Mabe that explains why the ex is an ex…
kate loving shenk
November 30th, 2006 at 11:44 am
yes, last night i found myself talking at great length to fellow nurses about Dawn dish soap and the new product called "citrus kick" which gives off a very lively oder as you wash the dishes.
at 3 am in the morning–
and i thought the whole topic was totally interesting–
November 30th, 2006 at 2:39 pm
Old men are gossips!
My Dad's a retired car dealer, and those guys gossip like you wouldn't believe!
Jean-Luc Picard
November 30th, 2006 at 4:05 pm
There are a lot of blabaholics around; they go on…and on..and on.
another nurse ratchett
December 2nd, 2006 at 1:56 am
Had to laugh at that, especially in view of my last annual review at work, where my manager commented that I was "verbose at times" in my documentation. Verbal as well as written communication is apparently addictive then.
December 2nd, 2006 at 10:27 pm
High five to Apgarn! Yikes! The desk is insane at change of shift on L&D. We changed over to doing some change of shift in our break room, though that room is extremely small. We are not supposed to chit-chat at the desk at change of shift anymore, nor are we to give/get report at the desk. Ugh. They want us to do report in front of the patient – something that many of us still won't do, because of the sensitive nature of some of the medical history (STD's, HIV, etc).
The volume at the change of shift is just incredible………
And lordy! We can and do talk about EVERYTHING!!!
December 4th, 2006 at 2:32 pm
Good Lord, they may be on to something, cause God knows TC loves to hear herself talk. But an addiction? I mean, isn't there some biological imperative for women to be so talky?
December 4th, 2006 at 7:04 pm
If it is like heroin then how come ny ass is still big? I know I can talk my own ass off. If not, then my new office mate can for sure! I love the lady in the book cover grabbing the Dr by the arm. Is she trying to finish a sentence or keep him from dailing the number.
December 13th, 2006 at 10:00 am
See, I knew I was a freak. I hate small talk and chitchat; in fact, I just made a whole post about how much I despise the whole Christmas shopping conversation thing this time of year.
However, if it's going to give me some sort of buzz, perhaps I'll reconsider.


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OMG! Shocking Kid News
Youve heard the news items or maybe you missed them. Take a look back at the funny, crazy, touching, and unbelievable kid stories and videos that made headlines across the web (and the world).
Visit msnbc.com for breaking news, world news, and news about the economy
"I Dont Like You, Mommy"
Honesty is the best policy, or at least this three-year-old boy thinks so. He tells his mom exactly what he thinks of her when she's not giving him cookies, no reservations.


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Jo Ellen Newell
Birth Doula located in Dayton, Ohio
- Categories: natural child birth
- Address: Map
- City, State: Dayton, Ohio Country: United States Postal Code: 0
- Phone: 937-754-1736 Fax: Not Available
- WebSite: No Website
- Email: Jo Ellen Newell Contact: Jo Ellen Newell
- Description:
Jo Ellen Newell, Birth Doula located in Dayton, Ohio. Is this your listing? Please contact us to update it.
- Online Ordering: No
No comments yet
your comment about Jo Ellen Newell
Solicitations Will Not be Added


text:
At Lincoln Center, it's film as urgent jeremiad.
In theaters, on demand, or wherever
Get your tickets for the end-times
Outré cinephilia with the bridge-and-tunnel set
Lebanese film series illustrates the absence of sense in a 15-year fight
Clip Job: an excerpt every day from the Voice archives. January 13, 1966, Vol. XI, No. 13 Film Critics Choose Their Favorites for 1965 By Jonas Mekas Once more we are playing the Best Movies of the Year game. The usual answer this year is that even the best ones are hardly worth listing a ... More >>
Plus Ken Jacobs retrospectives, Alexander Medvedkin revisited
A look back at a year when the whole world was watching
Harun Farocki gets his kicks out of soccer and video
Idiosyncratic sci-fi films Sans Soleil and La Jetée hit DVD. Plus, good directors gone bad and bad directors gone worse.
Three-week fest at Film Forum, plus the filmmaker in the flesh
Despite a nonexistent marketing campaign, Cuarón's latest is not to be missed
Chris Marker and his feline friend document post9-11 France
The Top 40 Picks of the Tribeca Film Festival
Sexual mismatches and menopausal horror in French series
After Sundance short-shrift, American independent films get their due in Rotterdam
Play it again, samurai: Sword plays and bandit ballets in this razor-sharp summer series
25 movies to catch at the Tribeca Film Festival
Labor's Love Lost
The Persistence of Memory
Cosmic Profs Beat The Clock
Scrap Mettle


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This is a big deal for Comcast and the future of online video in general, and Hulu in particular -- since Hulu is a joint venture of NBC Universal and News Corp.
With or without ownership in NBC Universal, Comcast's impact on Hulu and the overall Hulu experience already has been substantial. The cable giant's 800 pound gorilla influence has significantly pared back the amount of content (TV shows) available on the site. In other words, Hulu already is not what it was and, ultimately, Comcast's actions -- and those of other cable companies (and hence, the media companies that need them) -- will marginalize the current power position held by the company.


text:
Counterfeit Products
$86M In Fake Merchandise Seized At MIA
Agents with U.S. Customs and Border Protection (CBP) at the Miami International Airport have been busy lately taking more than $86 million worth of counterfeit and pirated merchandise into custody.
Feds Seize 150 Counterfeit Websites Boasting Holiday Deals
All around the country, shoppers hit the web for cyber Monday sales. Maybe you were looking for shoes, designer bags, or sunglasses. But some shoppers may have seen warnings saying the Feds seize 150 online stores. Some right here in Florida.


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As we all know, great looks start with a good canvas, and the Proactiv's Refining Mask, recent winner of Allure's 2011 Best of Beauty Award for "Best Mask for Oily Skin," is the perfect pre-makeup mask to create a clear canvas for your look. Using the mask will help to dry out and prevent blemishes with a powerful 6% concentration of antibacterial sulfur. Sulfur is a good alternative for those who might be sensitive to salicylic acid and/or benzoyl peroxide. I find that for me at least, sulfur doesn't dry me out as much.
You apply the mask on damp skin (which I find interesting, most masks go on dry skin), wait for about 10 min (which is not bad at all, a lot of masks take 20+ min), and wash off. Unlike many deep cleansing / acne masks, this one doesn't dry out like clay (which sometimes makes me feel like my skin is about to get pulled off of my face *don't like that feeling at all*). After washing off the mask I found that my skin looked much brighter, cleaner and yet doesn't feel dry and tight. As far as curing acne goes, my pimples didn't get worse and they seem to be healing at a pretty good speed :) Glad I had the chance to try this mask, it's good!
If you have any pesky pimples that stick around, Proactiv's Concealer Plus, a concealer and spot treatment in one, a product that has the same powerful sulfur in the Refining Mask, plus the added benefit of makeup coverage, can *probably* help you achieve a spot-less look.
I however, didn't find this concealer that useful. I tried it on my chin, by dotting it on...
and then patting it down to blend it, but what was left was rubbed off product and a blemish that was not concealed at all =/ I find the consistency might be too liquidy to properly conceal blemishes. It works ok on the redness around my nose though.
Also, don't forget to clean and moisturize your skin before hitting the hay. Proactiv Makeup Cleansing Wipes are pre-moistened with a nourishing soap-free cleanser to remove all the makeup. And for those that are super oily and seek a moisturizer that is feather-light, you should consider the Green Tea Moisturizer, it provides nourishing and botanical-rich hydration in an oil-free formula. It applies almost like a light serum. For those who have normal/combination/dryer skin, I would recommend you try something else as this wasn't moisturizing enough for me.


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Mobile Access to Services
This page contains useful information for those wishing to access services over GPRS networks. The recommended carrier is Vodafone although others should work.
GPRS connection settings
The best way to setup your phone is to go to the phone vendors website and get a GPRS configuration text sent to your phone. These are available for Nokia, Sony-Ericsson generic information of the settings for Vodafone can be found at an expansys forum.
Email to Hermes
For most users the simplest way to receive email remotely as well as when in the Laboratory is to store their email on the Computer Service hermes mailserver. This provides an IMAP services as well as Web based browsing facilites. To access this service from a Mobile Phone or GPRS connected device you need to configure the Mail client to access imap.hermes.cam.ac.uk over a secure (SSL) connection. You will then have to associate the usename and password with this. You should set the SMTP server to be smtp.hermes.cam.ac.uk again over SSL. Email can then be collected and processed from your phone. You should ensure you have set up the download options to minimise data traffic.
Email to the Computer Laboratory
To access email on the Microsoft Exchange server you need to either use a GPRS or Wireless connection to the mob.cl.cam.ac.uk or other access point as Active Sync works over https.


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iBUYPOWER PRO-SERIES TGP300 Gaming PC - 3rd generation Intel Core i7-3770 3.40GHz, 16GB DDR3, 1TB HDD, 120GB SSD, 2GB NVIDIA Quadro 4000, 750 Watt, Liquid Cooling, Windows 7 Professional 64-bitItem#: I455-13013 | Model#: TGP300
- Price:
- $2,349.99
- Shipping:
- In Stock, usually ships within 24 hours (Details)
Additional Resources
iBUYPOWER i7 1TB HDD/120GB SSD 16GB DDR3 Wkst Product Details
iBUYPOWER PRO-SERIES TGP300 Workstation PC
The iBUYPOWER PRO-SERIES TGP300 Workstation PC is a great computing companion for your hardcore gaming, intensive business computing, or your enthusiast type of multimedia lifestyle. This amazing PC delivers impeccable processing performance catered by the 3rd generation Intel Core i7-3770 3.40GHz processor. Armed with 16GB of DDR3 memory, the iBUYPOWER PRO-SERIES TGP300 Workstation PC will surely handle lots of demanding tasks without sweat. It also delivers astonishing graphics performance; get ready to run games or media applications with blistering frame rates with its NVIDIA Quadro 4000 GPU with 2GB of DDR5 video memory. This workstation class PC is equipped with a terabyte hard drive plus a 120GB solid state drive for all-out storage performance across the board. And with the 750W power supply it possesses, it allocates clean current to all hardware. Don't even forget its compelling liquid cooling setup for super efficient heat dissipation. Order the iBUYPOWER PRO-SERIES TGP300 Workstation PC for your demanding workloads or gaming cravings today.
What It Is And Why You Need It:
- 3rd generation Intel Core i7-3770 3.40GHz; amazingly smart processor that delivers staggering performance
- 16GB of DDR3 memory; for superb class multitasking
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- 1TB hard drive and 120GB solid state drive; provides ample storage for your tons of data packed with blazing fast transfer speeds
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- Liquid cooling setup; helps you to disperse heat on the system quickly
Genuine Microsoft Windows®
- Operating System: Genuine Microsoft Windows® 7 Professional 64-Bit
- Start-up Operating System: Genuine Microsoft Windows® 7 Professional 64-Bit
Additional Resources: Product Manuals
Manufactured by: iBUYPOWER
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Limited Warranty: 12 months parts; 12 months labor
Mfg Part No: TGP300
UPC No: 848604002842
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Shipping Weight: 42.0000 pound(s)
Click here for full warranty and support information
- Limited Warranty: A full text version of the limited warranty
may be obtained by mailing a self addressed, stamped envelope to the
address below and requesting the warranty for item number: I455-13013
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text:
SUCCESS Academy Administrative Staff
Brian Reid
Assistant Director
Counselor-DSU Campus
Business Manager
Registrar-SUU Campus
Registrar-DSU Campus
Concurrent Enrollment-SUU Campus
Brian Reid
Assistant Director
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SUCCESS Academy, an open enrollment public charter school aligns with federal and state law and policy, and prohibits discrimination
based on race, creed, color, gender, religious affiliations, ancestry, disability, or need for special education services.
Information on this Web site may contain technical inaccuracies or typographical errors. SUCCESS Academy assumes no responsibility or liability for damages incurred directly or indirectly as a result of any errors, omissions, or discrepancies. Information may be changed or updated by SUCCESS Academy at any time without notice. SUCCESS Academy may also make improvements and/or changes in the products and/or the services described in this information at any time without notice. Southern Utah University allows this web page to function through its computing system and facilities as an educational service. The views, opinions, information and conclusions expressed on this web page are exclusively those of the author or organization, acting as an independent publisher, and are not to be attributed to Southern Utah University, its officers, or employees. The content of this web page has not been reviewed or approved by Southern Utah University. The author or organization is solely responsible for its publication and content. This site is hosted by Southern Utah University:


text:
Open source: a savvy bet, even in tough times
Even as the economy slouches its way toward another bout of recession, the software industry has been in comparatively rude health. Earnings across the board have been impressive and, as a recent SIIA and OPEXEngine study (warning: PDF) shows, software companies are returning to robust profitability after years of red ink. In …
Image link
"Still not convinced that open source offers a better way to build a business? Consider revenue growth rates for public and private companies over the past few years, according to these OPEXEngine benchmarks, below."
Yes, wouldn't mind looking at it if it were linked to a larger image one can actually read.
Image link
Yes , me too AC!
50% of Nothing is Nothing
I am a big advocate of Open Source software. But without actual sales figures your article makes no sense. Just quoting percentage growth figures is just plain useless. A relatively small company with a few million or a few hundred million in revenue can experience high percentage growth, even 100% over an extended period. But this cannot be considered significant if their share of the industry revenue is minimal.
Just quoting percentages without mention the actual revenue figures is just plain misuse of statistics.
Reminds me of a quote from one of my former bosses. "Statistics is like a bikini. What it shows is interesting but what it does not show is desirable..."
748 Million Dollars is Nothing ??
Redhat Revenues for the last four years:
Not exactly nothin.. Not exactly tiny growth...
Certainly that is tiny as compared to MS or Oracle, but Redhat clearly approaches the same league as these companies. They have a broad product line (OS, compilers, applications servers, databases, browsers, debuggers (admittedly as part of a larger FOSS movement) ) and they have built a very strong reputation in large corporations, including the Tokio and Frankfurt Stock Exchanges.
Redhat Linux is considered rock-solid, and it is the default for corporate Linux users. in large-scale applications, Linux is already the dominating operating system. Other Unixes, MVS and Windows Server are all either legacy or irrelevant. Windows Server only matters where the there are not enough skilled sysadmins and/or programmers available. Small-scale stuff, generally.
I personally don't like Alfresco, but it certainly is an option to consider as MS Sharepoint has a very hefty price tag attached. Free crap like MySQL made it big-time, so why shouldn't Alfresco ?
Alfresco might only be important as a trailblazer for FOSS document management, as much as MySQL paved the way for Postgres. Someobody else will be able to create something more coherent based on Samba, Lucene or Xapian, Apache, Postgres and Python.
You missed the point completely.
Title said it!!!!!!!!!!!!!!!!
Ignorance should not be mixed with prejudice in public
"Other Unixes, MVS and Windows Server are all either legacy or irrelevant. Windows Server only matters where the there are not enough skilled sysadmins and/or programmers available. Small-scale stuff, generally."
Let me stop you there without engaging your prejudice directly by simply saying that I have personal experience of globe spanning windows systems, so your assertion fails in basis of fact. This is what happens when you imagine the world is precisely as you wish it to be rather than as it is, or when in fact you have no actual experience of what you are talking about.
You may also be interested to know that PostgreSQL predates MySql by (at least) five years, and has generally had quite a lead in terms of features.
If you're going to wave your geekWang around and pretend to be a big swinging unix dick, you need some facts to bolster your prejudice. And a beard.
Postgres, MySQL
What I meant to say is that MySQL "legitimized" the use of Postgresql in the corporate world. MySQL had a great marketing machine to sell something crappy. Now people realize they can use an open source database and Postgresql is the better technology.
Regarding your Windows system - what is it doing ? A large set of Exchange servers running in a corporate ActiveDirectory Domain ? Attached to a large number of big file servers maybe ?
Or is it a complex, custom system running a stock exchange ? Is it running SAP ? I guess it's not.
Bzzzt! That's the fail buzzer.
"What I meant to say is that MySQL "legitimized" the use of Postgresql in the corporate world. MySQL had a great marketing machine to sell something crappy. Now people realize they can use an open source database and Postgresql is the better technology."
No. Know how I know this ? Because I was prototyping corporate SaaS systems built on PostrgreSQL long before the web kiddies started beating their chests about MySQL.
"Regarding your Windows system - what is it doing ?"
Systems. Plural. But to pick just one : running a multinational pharmaceutical company's entire operation from document management, through mail, through ERP, through warehouse and logistics through monitoring and real time production in factories.
You need to get a dose of reality here and understand that some very large shops run end to end MS kit.
"Or is it a complex, custom system running a stock exchange ? Is it running SAP ? I guess it's not."
I bet you've got the slashdot post about the LSE switch to Linux printed out - with all the comments - and hanging on the wall of your room at your mummy's house, probably all neatly arranged around your candle-lit Stallman shrine. But then again, Direct Edge, Karachi, Bovespa.
You seem to be under the impression that there are no large volume trading systems that aren't based on Linux, once again if we compare your imagination with reality we see there are some large differences.
Linux is unquestionably a good OS and has scored some seriously impressive real world wins, and I have no doubt that it will continue to do so, but your assertion that MS does not, can not, and will not play in these same markets simply doesn't hold up to examination.
And by the way, you do know that you can run SAP on Windows ? With SQL Server as a backing store ? You knew that right ?
LSE - Didn't They Bomb With .Net ?
I am very familiar with Stock Exchange Tech as I worked on that. AFAIK know, LSE had big trouble with a .net soluation hacked up in India.
Kable reports
"Francis Maude has said that when costs are similar, the government will buy open source rather than proprietary software."
This is going in the right direction, but it still omits to take into account the effect on local economies. Although rarely evidenced, the argument usually goes that (closed source) proprietary software ends up being less expensive because the costs of support are lower.
In fact, even if the overall costs were the same there could be a significant benefit from using open source. A greater proportion of expenditure would be local and would thus provide a local stimulus to the economy. In addition, though planners don't usually pay much heed, long-term costs could be reduced through the use of standard and accessible data formats.
But at least Mr Maude seems to have listened to advisers. Maybe the efforts of David Villanueva Nuñez were not in vain.
preaching to the choir
Most of the people on here that rail against open source are not the decision makers that look at ROI. Most seem to be hack parochial MSCEs that are scared about having to learn new technology (I might actually have to use a command line, OMFG!). As you can see from lack of posts they tend to skip articles like this that don't directly mention M$ and their skill set becoming irrelevant.
Monkey nuts
While it may indeed be true that the average MCSE is little better than a trained monkey, and often much less entertaining, a freetard calling an MS pro 'parochial' is keyboard destroyingly funny.
And don't get your little linuxy frillies in a twist, MS have enough market share that they aren't going anywhere for quite a while.
confused. The author seems to tout open source as being able to do more with less and stuff, which is true in a lot of areas. Where my confusion goes is the choice between using the commercially-backed open source(e.g. red hat) where you pay the subscription($349-749/server on the low end) or if you go the truly "free" route, which of course saps much needed revenue from those companies trying to capitalize on open source.
I know there's a balance in there somewhere, but as someone who has been using open source for 15 years now in my daily personal+professional life (yes even on my laptop), I do wish more organizations would support the movement more, the easiest way to support open source is to subscribe to the various services these companies(e.g. red hat) are providing. Participating in the community directly is just as good but takes a lot more time and it seems only a tiny minority of the users actually do it.
I suppose the growing revenues of the likes of red hat is a good sign, but it is of course a tiny tiny tiny fraction of those benefiting from the development that goes on that do not pay a dime. Imagine where we would be if the ratio was different, even at lower prices (made up with higher volumes).
Surprise me with high growth from low base...
Poor quality, total costs high
I've talked with some engineers I know at amazon, and it's by no means obvious that open source is a good idea. You get low quality software and will spend a lot of money hiring people to keep it working, patched, fixed, etc.
Asbestos pants handy then ?
"You get low quality software"
Oh I'm going to enjoy the FOSS massive spitting it's dummy over that, but it is largely true, I actually use a lot of FOSS bits n bobs and I constantly see code that would never pass QA in grown up software development.
It isn't universal though, and curiously enough some of the projects that achieve consistently high quality are the ones that have a commercial model, because as you rightly say ...
"and will spend a lot of money hiring people to keep it working, patched, fixed, etc."
The ROI tradeoff is exactly the same as it would be with closed source, is it cheaper to do it here or be a customer amongst many sharing the costs of development.
So basically commercial FOSS is competing on price and quality, with openness being largely irrelevant, and if FOSS shops can do it cheaper or better because they can exploit useful idiots who will work for free then they win. Obviously this is much nicer than the horrid proprietary capitalist pig dogs.
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Search Result
Search Tags: pew research center
More home caregivers turning to Web for advice
As the number of Americans caring for older family members or chronically sick children grows, more people are turning to the Web for advice.
Tags: caregiving, caregiver, medical advice, Hank Silverberg, susannah fox, geriatric care, extended families
Who has more leisure time, men or women?
A Pew Research Center analysis finds men have more leisure time than women. What do you think?
Free Internet is a big draw at libraries
A new survey shows free Internet access may be just as important as the ability to borrow books at libraries.
Tags: Libraries, internet access, Hank Silverberg
More finding news online and on radio
The Pew Research Center survey found 39 percent of those under 30 say they read yesterday's news online or on mobile devices, with 78 percent of those people getting their news via cellphone.
Tags: Hank Silverberg, TV news, cellphone
Parents' texting obscures warning to teens
In an online survey of teen drivers with smartphones, while young drivers hear their parents warnings, they see those parents texting "all the time."
Non-smartphone users soon in the minority
For the first time ever, more people own phones with apps and Internet access than other types of cellphones.
Tags: smartphone, Pew study, cellphone, Hank Silverberg
Formerly a crime, Va. now leads in black-white marriage
The Pew study, released Thursday, says Virginia now leads the nation in percentage of marriages between blacks and whites, which until 1967 had been a criminal offense in the state. The study finds the children of interracial unions are challenging the typical notions of race.
Tags: interracial marriage,
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