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Another week, another Griff Bag! Aka Richard Griffin's latest mail bag from over at the Toronto Star! Er… except that I haven't actually done one of these for a couple of weeks, but why let that spoil a good opening line?
If there's a question you'd like me to answer, unless it's about fucking Ricky Romero and J.P. Arencibia, submit it to Griffin here, and maybe he'll select it for a future mail bag. Fingers crossed!
Q-With the season in full swing and drawing to the crunch. I have a question regarding this offseason, the Jays have projected payroll of controlled/buyouts of 96 million. With the dominant starter still not there to stop the bleeding on a Jays team, would it be at all possible that the Jays are able to trade Buehrle (20 mill next season), and Dickey (12 mill next season) without including a bunch of cash going the other way? The reason I suggest this is that they could then replace those 2 starters with more proven, reliable starters, 1 of the following of ie Ervin Santana, James Shields, Jon Lester or Max Scherzer? Then sign a Jake Peavy, Brett Anderson, Josh Beckett, Justin Masterson, to be the 3 or 4 starter? I know it is Fantasy baseball talk here but wouldn't one of those aforementioned pitchers be a better option then Buehrle for the same type of coin and the latter be better then Dickey?
Scott Cochrane, Niagara on the Lake
Uh… why would a team agree to take on Mark Buehrle at the full freight of $22-million for next season when they too could give up nothing and sign one of those guys that you mentioned? Where is the advantage for the other team? Is it that they may not be able to sign one of those guys themselves? Because that makes no sense — they have the money, and pretty much any team is as likely to sign a free agent pitcher as the Jays are if the money is there. So… ?
Dickey you'd have a better time giving away, but not seeing how $12-million on the free agent market gets you 200 virtually guaranteed innings of a former Cy Young pitcher with a sub-4.00 ERA in the AL East and a club option for 2016 at the same rate.
If you have an internal rotation option you believe in, or acquire a pitcher on the cheap, then maybe you take a bath on a portion of the last year of the Buehrle deal and repurpose those dollars into fixing the outfield, for example, but I'm pretty sure it's a lot harder to make this team better while taking away Buehrle than all the armchair GM's think.
Richard Stoeten,
With Jim Johnson recently signing in Detroit, this really shows that the Jays have their purse strings tightly wrapped. He would have been a good shot in the dark pick up, considering he is 31 and the Jays are looking for late inning help, he would have fit nicely in at the back end of the bullpen. Prior to this year he has had 100 plus saves in the AL East, why wasn't he looked at for the Jays bullpen??
Scott Cochrane, Niagara on the Lake
Because he's been terrible, because he has to want to come here, and because the Jays don't have room to carry an experiment at the back of their bullpen — and if they did they don't have the innings to give him to get himself straight anyway, which is exactly why Steve Delabar and Sergio Santos are in Buffalo.
Be serious.
Richard Stoeten
Don't know about you Griff, but after the recent ups and downs I am now in Doris day mode – 'Que Sera Sera'. So a couple of non "are they going to make it" observations.
I don't know if you caught Dave Bidini's article in the Post about going to watch the Jays at the old Ex. For me it brought back a ton of memories of going there for the first time back in 1978 – including not realising why everyone (and there weren't a lot) rushed to the back of the stands when the seagulls arrived. I still remember it as the time when I really fell in love with the game. Previous visits to Fenway with an uncle left me with a lifelong dislike of the fans and the stadium. Can you recall when you got the bug?
On a different note it's a bit sad to see some of the ignorant and offensive stuff being written on fan Boards/comments etc about Paul Beeston. (Only a bean counter- no interest in the Jays doing well are some of the more printable ones). I know he has made as many mistakes as anyone involved with the club but he has had a long and at times very succesful association with the team. Any chance of an interview with him?
all the best
Frank, Prescott
Yeah, yeah, Paul Beeston gives all the old folks a warm fuzzy because of his legacy of no one ever saying a bad word about him, built on his being drinking buddies with so much of the media. Or at least that's what I assume.
Whatever the reason — be it that, or the local boy made good angle, the simple fact that he presided over the team during its glory years, or some combination thereof — while I'm sure he's probably an awesome dude who has done some great things, the fact of the matter is, if you want a progressive, boundary-pushing organization that will seek out all paths great and small to gain a competitive edge on a league filling fast with progressive, boundary-pushing organizations, you don't, in the year 2014, have Paul Beeston running it.
If you care less about the end result and more about installing a P.R. shield who'll always have the company's back and fosters goodwill among the core believers in the brand, then sure, he makes perfect sense.
That isn't to say that I don't think he wants the team to be good — that's ridiculous, and I have a hard time believing you've found anybody half serious who would actually say so — and it isn't anything personal, it's just… his being in the position he's in speaks more to what Rogers wants than we sometimes like to believe, I think. And what it says ain't good, I don't think, if you're a fan who wants the Jays to be a team capable of running with the big-money, ultra-smart teams in their division — especially when they're going to have large self-imposed budget constraints.
Hey, nostalgia, though, eh?
Richard Stoeten,
with the series almost done in Houston it seems the air was let out of the balloons rather quickly. With the no action on trade deadline the morale seems to be gone from the locker room. The inaction of the front office spoke loudly to the players, go out and play and do your jobs and we won't be able to reinforce you. How in the world did AA not pick up Martin Prado?
You can't fault AA for the inaction if it boils down to money but if the money was there and he didn't take any then it is his fault. The east is at hand with 2 teams in the race, how did AA take no action?
Scott Cochrane, Niagara on the Lake
Weird. It's almost like this kind of horseshit ends up looking dumb as fuck a few games later — like a baseball season has all kinds of ebbs and flows that make it unbelievably ridiculous to view things through the immediacy of misplaced "must win," "season over," and "this means something" prisms. And the worst thing is that people who hold these sorts of opinions don't ever seem to notice how quickly the thing they thought two weeks ago became asinine.
Anywho, no, the inaction didn't speak shit. The Prado thing would have likely blown whatever budget there might be to re-sign Cabrera. And for what? To add — as I've written before — a guy who is only barely an upgrade, if at all? He's been below replacement level as a Yankee; his 86 wRC+ this year makes it a second straight decline year, and a third year of four in which he's been league average or below at the plate; his most valuable defensive position is the one Brett Lawrie was about to come back take over at the time of the deadline; and he's at his best against left-handed pitching, which the Jays already have the much cheaper Steve Tolleson and Danny Valencia to do almost as well. So can we please stop talking about Martin fucking Prado? Whine about something that makes sense to whine about if you have to be this sort of insufferable fan.
Richard Stoeten,
Can the AL East still be considered a weak division now that they have more wins than any other division in baseball? If the Jays don't make the playoffs, and I think that they will, AA should not be fired at the end of the season. AA has towed the company line and refused to admit that he is under strict financial constraints from Rogers. He has done a great job of pulling players off of the scrap heap who have value. I don't think that he will win a World Series that way but maybe an attendance bump from a competitive season and a decent run in the playoffs will loosen the Rogers purse strings a little more. Would a perennial contender not be a financial win for Rogers?
Matt Meisner, St. Catharines
I don't know that straight wins really is the measure of what makes a division good or bad, but really it's just semantic nonsense anyway. Maybe it's wrong, but I don't know… there are major flaws in all of the AL East teams, and less so in the A's or Angels, I'd argue. Doesn't really matter anyway, though, what the label is.
As to whether or not Anthopoulos should be fired, it really sometimes seems like we're deep into J.P. Ricciardi territory here, where the G.M.'s greatest talent — better, even, than building a baseball team — is understanding how best to preserve his job. I happen to think that Anthopoulos isn't nearly as cynical as his predecessor in how he operates — Ricciardi would, to his team's detriment, avoid selling off pieces at the trade deadline in order to preserve his ability to sell false hope down the stretch, and I don't think the same can be said of Alex — but he certainly is a good soldier for the company, and I bet, internal to the company, that goes a lot farther than whatever baseball acumen he possesses does. Ricciardi, once he saw the writing on the wall, started griping about Rogers and money, seemingly hoping that he might find support, or perhaps to somewhat preserve his reputation enough to land another job. Anthopoulos hasn't yet shown he's willing to do that, meaning he either knows too well that it won't work, or that he doesn't think the writing is yet on the wall. Maybe both.
And yes, a perennial contender would be a financial win for Rogers, one assumes, but not at any cost. They make plenty as it is, and… shit, you almost hope that there's something in the cost/benefit analysis that keeps them from spending bigger or trying harder to make this situation better. Otherwise, what the fuck excuse is there?
Richard Stoeten,
Based on their recent performances, I'm wondering if it would make sense to transfer Todd Redmond to the starting rotation to replace Drew Hutcheson.
Richard Stoeten,
Let me start off by saying that I usually don't get caught up in what's being written in sports pages and what is said by players, although I do enjoy reading the opinions of yourself and others. After all when you think about it, baseball is just a game. It teaches you about competition and what it's like to be a part of a team. I liked playing, watching my son and daughter play, watching the Expos and watch the Bluejays at every opportunity.
My rant – " Blue Jay's Jose Bautista disappointed team didn't improve at deadline." This one really sticks in my craw. Isn't now the time to close your mouth and open your glove (last night's game) instead of dissing on your team mates that have currently helped you to a six-game win streak? This guy is being paid more money then most people will see in 10 life times, he is supposed to be the team leader (yes, everyone does it differently). I can't help but wonder how players like Danny Valencia, Nolan Reimold, Ryan Goins, Marcus Stroman, and Aaron Sanchez feel. Shouldn't a real team leader stand behind his team mates and the hands that feed him? I would like to think a team leader might say to his team that management has the confidence in us to win with the players that we have now.
I would appreciate your opinion.
Bob Andrews, Brandon, Manitoba.
Yeah, they should to'lly strip 'im ov the "C," eh? Gotta give a-hunred pe'cent in the room an' on the ice. Geh the fuck outta 'ere wit that fuckin' attituude, eh bud. Gimme a leadre like that Laurie kid, always playin' like it's game seven!
Richard Stoeten,
It's interesting, and perhaps worrying, to see some of our key veterans vent their frustration about the inability to obtain help at the trade deadline. Not surprising though. This is such a hot/cold team this year and while Reimold/Valencia and the return of the injured bodes well for the offence, how is the starting pitching going to hold up without reinforcements? Dickey and Buerhle are solid and consistent, but old and neither is an 'ace'. Who knows when their durability hits a road bump? Stroman is excellent, but presumably on an innings count. Hutchinson is becoming a worry and also on a count. And Happ is Happ. Morrow is coming back hopefully, and maybe he helps, but we've lost Rogers who had some decent starts last year and Hendricks (even though he got hit hard). But isn't it blindingly obvious that we need starter help to make it to the post-season, or fingers crossed, deep into the post-season? I'm not saying we should/could have got Lester or Price, but I wonder if that's the core of the player frustration. Do you think AA is going to pick up a starter in August and who potential targets/options might be?
Rob Brander, Sydney, Australia
It's not obvious that they need a starter, no. It might become obvious, and if one of their current group gets hurt or hits the wall, yeah, they'll want one — Sean Nolin currently seems to be next in line, unless they go to a Todd Redmond or Chad Jenkins. Maybe they'll get fearful enough of continuing to rely on Hutchison that they make a move. Not sure it would have been fair or smart to move assets to make that switch a few weeks ago, and… OK, maybe now it is. Fortunately, like you say, trades can still be made in August.
The guys available are basically the same ones we talked about through all of July, minus the ones who don't clear trade waivers.
Yeah… I don't know…
Q-Dear Mr. Laurence,
I appreciate that you are likely walking into a difficult job, Rogers being one of the largest communications companies in the country, but I find your conduct regarding the Blue Jays to be quite disturbing.
So far, all I have heard (second hand through your representative management in the Blue Jays organization), that you are "interested in winning" and that the "resources are available" should they be needed. All evidence that has been presented recently however, is quite to the contrary.
In the last few days leading up to the trade deadline, I have heard nothing but reports (from the most reputable sources in baseball) that the Jays will not take on salary because they are "capped out". Looking at the TV numbers and the gates recently (not to mention the MLB TV money), I can't imaging that lack of revenue is an issue unless this shortfall is self imposed.
Can you explain to me why this is? I can only think from this that you do not consider the Blue Jays to be a legitimate business in your "Empire" because you would not and have not conducted your affairs anywhere close to the same way as this with your other units.
The NHL deal alone is evidence that you are cutthroat and aggressive in your normal affairs. When it comes to the Jays however, the desire is lacking. If Telus or Bell had managed to score a major competitive edge against you in the Telecom or Media department, you would make it a point to strike back as quickly as possible to regain the advantage. When Detroit or Oakland do it however, you allow it to happen with little more than a shrug.
As you can tell, I do NOT believe that AA is responsible for this lack of movement. If he has to take any more bullets for you, he's going to need to come to work in a Kevlar vest. Reviewing the trades made for "Aces" (at the deadline), even conservatively, these deals would not have been stretches for the Jays to make if they were allowed.
You owe us an explanation…From Rogers DIRECTLY! Alex or Paul will NOT do in this case. We want to know why it is acceptable for you to be essentially punked by your competition and for you to have essentially no answer for your lack of action.
The team is performing remarkably well given the situation. We all know they can't go too much further without help (this is not a "Miracle on Ice" situation here).
If the fan base truly understood your apparent lack of interest, your "investment" would drop off a cliff and you would have nothing to show for it but "content" for your channels, which seems to me to be your only present concern. You are not the Leafs…you know this can happen in this city very quickly.
As someone in accounting and finance myself, I understand the danger of "bottomlining" this type of operation. I only pray you realize the potential results of your actions before too much damage is done…to the team, the fan base, and your asset.
Thanks for you time,
Alan Jukes
Aww, feel better now, Alan?
OK. Now, let me get this straight: you're surprised that there's a difference between what the company says and what the reality is? Uh… this should probably just be assumed. Pay attention to what they do, not to what they say.
And yes, the amount of money that's there is subject to a limit set internally… like every other MLB team. Maybe it's lower than you'd like, but the idea that the Jays might not be considered a legitimate business within the Rogers empire is absurd. They're an important piece of content for Sportsnet, and because of that relationship, which is entirely internal to the parent company, the equation is different than the examples you use. It's certainly different than the example you use about the telecom industry — the cost/benefit isn't nearly the same, nor is the potential for profit.
With a baseball team, the key is equity. Rogers bought the Jays for $120-million in 2000; Bloomberg valued the team at $950-million a year ago, and Forbes put their value at $610-million. The Jays haven't sniffed the playoffs, yet the value of the asset has skyrocketed. There must be value in their being better, but enough to justify the cost of really making the effort to do so? Apparently not, judging by their actions.
That, I think, is all it is. If they saw massive untapped potential I have a hard time believing they wouldn't be trying better to tap into it. And it's certainly not just a microcosm of Rogers' other operations.
The sentiment here is great and all, it's just… let's not be too naive. The aces that were dealt before July 31st certainly weren't as feasibly attainable by the Jays as you believe (see below), and I think it's already well understood that Rogers is a dispassionate — if not disinterested — owner, and nothing has fallen off a cliff. They're doing just fine, in fact. The scary warning stuff simply won't work — not when we're talking about an asset possibly worth something like 800% more than what it was acquired for 14 years ago, especially when they spent many of those years finding some pretext or another to run it on a shoestring.
It is what it is.
Richard Stoeten!
A lot of people are saying how the Jays should've gone "all in" to get the players they need at the non-waiver deadline. Commentators like Zaun pointed out that their prospect cupboard is bare, which could be a reason why they couldn't trade for players they need.
But I'm thinking: of course their cupboard's bare! They traded away their most highly touted prospects two years ago (e.g. Justin Nicolino, Jake Marisnick, Adeiny Hechavarria, Travis D'Arnaud, Noah Syndergaard) to go all in for players like Buehrle, Reyes, and Dickey thinking they could make the playoffs last year. It takes time to develop the players to refill the cupboard, and there are only so many times you can go "all in" in a short time span. So why is there still surprise that the Blue Jays have no prospects to offer in trade?
Al, Toronto
I have no idea why that's a surprise, Al. You're absolutely right. And they certainly do have a tonne of talent at the lower levels, and that they obtained in June's draft, those just aren't the kinds of commodities that brought back the kind of talent on July 31st that Jays fans wanted to see. Maybe if they'd pooled a whole lot of them together, but even then it would have been tough to beat the big league talent acquired for guys like Jon Lester and David Price.
That said, obviously the talk about the cupboard being bare is off-base, idiot-empowering nonsense, too. Hey, but I guess it makes a good sound bite.
Richard Stoeten,
The basic premise of hitting is to hit the ball where the fielders aren't. With that said, can you explain why there was a backlash against Rasmus for bunting when there was a shift against him? From what I understand, if he did a full swing and hit the ball down the 3B line it would be fine, but because he bunt the ball it's somehow disrespectful? I thought it was a smart move by Rasmus and a great way to make the opposing team think twice about using the shift against him again. And if the opposing fielders choose to employ the shift and are practically giving you the entire left side of the infield, why don't players bunt down the line for an easy single more often?
Justin, Richmond Hill
There was a backlash because, generally, baseball players and the unwritten rules of the game are fucking dumb.
Rich Stoet,
I hope you are right when saying that standing pat at the deadline will not make the Jays weaker by way of the A's getting stronger and the Sox going through a pitching trade frenzy that is likened to a version of "Black Friday". The one thing that I have to consider in evaluating the quality of our front office namely AA, is how other GMs get deals done, and not necessarily the flashy deals.
Three trades that stand out to me as being level headed are the Price, Samardzija and Masterson trades. In order to evaluate the abilities of the front office to pull the trigger on a good trade, I need to frame the trades up with the relevant talent base from the Jays. I ask this as it seems they were level headed and not as one sided as most of the trade speculations with the Jays that would have to have involved at least one of our young arms. Can you provide a parallel to the Price trade with equivalent Jay talent?
That is what comparable talent would the Jays have parted with (based on what the Rays got) if they were to be involved? For example with the Masterson trade who in the jays minor league system would be comparable to James Ramsey?
Also, in your opinion which of the recent deals, specifically for Pitching help were level headed and which would you have like to see the Jays involved with?
I am glad to see, that the Jays are picking up steam again, I rather enjoyed reminiscing earlier this season with the SkyDome anniversary and early team success as it took me back to a time long gone when I was 15 and working at the Dome selling programs on its opening day, and the ongoing comparison of the current teams with the previous successful Jays. At this juncture of the season which of the previous teams would you still compare this squad to?
Thank you as always I genuinely feel that you are an integral part of maintaining the Jays fan base going.
The big O
For Price the Rays ended up with a young, controllable mid-rotation starter, a young, controllable infielder, and a very young shortstop prospect who, by some accounts, could now be the best player in their system. If you're asking the Jays to match that package, it looks something like Hutchison, Lawrie, and someone like Franklin Barreto, Richard Urena, or Dawel Lugo. They're having to play now without Lawrie anyway, and Price would likely have replaced Hutchison, so maybe the cost isn't as crazy as some like to say, but it's still pretty crazy — especially before Lawrie got hurt again, and especially because the $20-million or so Price will make next year (as opposed to the league minimum-ish Hutchison will get) would have constrained the club badly in trying to do anything else (like re-signing one of their free-agent-to-be outfielders).
As for Masterson? I don't know how much of a prospect Ramsey is, but I don't think it really matters. I'm not sure how much the 89-throwing, 5.94 ERA, Justin Masterson who has walked 5.24 batters for every nine innings he's thrown, and has averaged a hair over five innings per start, is helping this team.
Q-Hello sir,
Last night we saw Aaron Sanchez's fastball hit 99MPH, which is a filthy drastic change from Dickey's 65 MPH knuckler (Gibby should always follow Dickey with Sanchez!). Some DJF blog commenters mentioned how the Skydome radar gun has always been "hot", and that the actual speed may have been 2-3MPH slower… What is your opinion on the accuracy of radar guns in MLB today? What numbers can we trust?
Thanks, all the best,
Morgan Burton, Banff, Alberta
Trust the Pitch F/X, not the stadium gun. Per FanGraphs, the average on Sanchez's fastball has been 97.3, though he tops out higher than that. Those who think he sits lower may be remembering scouting reports from before he moved to the bullpen. Most guys, when they know they're in for just a short stint and don't have to conserve their energy for a long outing, will throw a bit harder.


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Cessna Shelves Citation Columbus Program
When Cessna chairman, CEO and president Jack Pelton said on Monday that the company's large-cabin Citation Columbus program was being slowed, few could have imagined that two days later the Wichita-based aircraft manufacturer would announce the suspension of the project. In a letter sent to employees yesterday, Pelton said that the "very difficult decision" to suspend this program will help "ensure focus is on our strong products in existing markets," adding that the Columbus project "still has great potential" and will be pursued "when the market recovers." The Columbus was launched in February last year after more than a year of polling customers about its large-cabin concept mock-up. Last month, Cessna announced it was delaying the Columbus project by six months, the first hint of R&D funding problems. Teal Group aerospace analyst Richard Aboulafia said the announcement is "bad news" and reflects either a lack of confidence in the business jet market recovery or fallout from Textron's finance division, which posted a $66 million loss in the first quarter. "I hope it's the latter reason," Aboulafia said.
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subset: commoncrawl


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Futures Dealers
All futures dealers must be authorised or approved and comply with the requirements set under the Securities Markets Act 1988.
Regulatory change coming soon:
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Google Links: 0 | Indexed Pages: 0 updated 25 Oct 2014
PageRank: N/A updated 25 Oct 2014
Internal Links: 0
External Links: 5 (0 nofollow)
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text:
November 2007: Volume 33, Number 11
Gene Expression Profile Tests for Breast Cancer Recurrence Do They Inform Treatment Decisions?By Deborah Levenson
Adjuvant chemotherapy for breast cancer significantly reduces risk of recurrence for certain women, but others experience the drugs' harmful side effects without any benefit. Current guidelines from the National Comprehensive Cancer Network recommend that oncologists consider adjuvant chemotherapy for women with tumors larger than 1 cm or smaller tumors with troublesome histologic features. While 80–85% of women with estrogen receptor (ER) positive, lymph-node negative cancers are adequately treated with hormonal therapy alone, the guidelines suggest that chemotherapy can reduce their relative risk of recurrence by about 25%. But research shows that chemotherapy confers an absolute reduction in risk for individual patients ranging from just 1–5%. Consequently, many studies have focused on better diagnostic tools to help individualize breast cancer chemotherapy. One promising approach is gene expression profiling, which includes tests that would help oncologists determine in conjunction with classic markers which women will actually need adjuvant chemotherapy. A few currently available and forthcoming gene expression profile assays are intended to reduce unnecessary treatments, yet oncologists are not always sure what to do with the data, especially if the results show the cancer carries a moderate risk of recurrence.
Using these tests poses another, more basic clinical question: How strong is the data? Most companies back up their claims about these tests—which cost from about $1,000 to more than $3,000—with data from retrospective analyses rather than prospective trials. Large ongoing trials for two of these tests may increase practitioners' comfort with them, but final data for both is years away. "The scientist in me says there's not data to say these assays have a prospective role in therapy decision making. But if my wife or daughter had breast cancer, I would want to them to get an assay," commented pathologist Michael Pins, MD, former director of the Eastern Cooperative Oncology Group Coordinating Office and Reference Laboratory, a solid tumor repository for one of the ongoing retrospective Trial Assigning Individualized Options for Treatment (Rx), commonly known as TAILORx, and Coordinating Officer of the pathology department reference lab at Northwestern Hospital in Chicago, Ill. He is now a practicing pathologist at Lutheran General Hospital in Chicago and Visiting Professor of Clinical Pathology, University of Illinois at Chicago College of Medicine.
Current widespread insurance coverage for the Oncotype DX assay developed by the reference lab Genomic Health (Redwood City, Calif.) and FDA clearance for marketing approval for Agendia's MammaPrint assay (Amsterdam, Netherlands) may make these two tests attractive options. As more oncologists and laboratorians decide what to make of these tests, they must decide if the tests will add useful information to the usual prognostic markers and if a patient's disease, age, and ethnicity is similar to a particular test's validation cohort, say experienced users.
Oncotype and MammaPrint: A Comparison
Since January 2004, more than 6,000 physicians have ordered the Oncotype test for over 33,000 patients, according to Genomic Health. However, Agendia will not formally launch MammaPrint in the U.S. until later this year. Not surprisingly, U.S. oncologists and pathologists tend to be more familiar with Oncotype. The test determines 10-year risk of recurrence using formalin-fixed, paraffin-embedded tumor tissue—which can be stored for years—to analyze the expression of 21 genes, five of which are reference genes. Samples sent to Genomic Health receive DNase 1 treatment followed by verification that samples are contaminant-free before they undergo reverse transcriptase-polymerase chain reaction (RT-PCR). The results of the test are used to assign a risk score that relies upon an algorithm which weighs certain genes more than others. Results are available within 10 to 14 days, according to the Genomic Health Web site.
Initial validation data for Oncotype, published in December 2004 (NEJM 2004; 351: 2817–2826), came from 668 patient samples from ER-positive, node-negative, tamoxifen-treated breast cancer patients of various ages who were enrolled in the National Surgical Adjvant Breast and Bowel Project clinical trial B-14. In that study, researchers classified 51% of patients as having low risk of recurrence, with a 6.8% rate of recurrence at 10 years. A smaller proportion—27% of women tested—was deemed high risk and had a 10-year recurrence rate of 30.5%. Researchers concluded that the recurrence score predicts both overall survival and relapse-free survival, commenting that "few assays have been rigorously validated for use as prognostic or predictive tests in oncology." More validation data came from a study conducted at 14 Northern California Kaiser Permanente Hospitals. (Breast Cancer Res 2006; 8: R25).
Beyond the validation studies, published research shows that Oncotype is indeed predictive. In a study of tumors from 651 patients treated with either tamoxifen alone or with both tamoxifen and chemotherapy, investigators from the University of Pittsburgh, Alleghany General Hospital (Pittsburgh, Pa.), and Genomic Health found that patients who had high Oncotype risk scores had large benefit from chemotherapy, while those with low risk scores had minimal, if any benefit. (J Clin Oncol 2006; 24(23) 1–12).
At least one study has shown that Oncotype risk scores affect treatment decisions. In a study of 93 patients in one community and three academic oncology practices, risk scores from the assay changed oncologists' recommended treatment plan in 31.5% of cases, according to data presented at the 2007 annual meeting of the American Society of Clinical Oncology by researchers from Loyola University in Marywood, Ill., University of Michigan at Ann Arbor, University of California-Davis, and Mount Sinai Medical Center in New York, N.Y.
In contrast, MammaPrint is prognostic rather than predictive, involves more genes, is applicable to a larger but younger group of women, and requires fresh or frozen tissue. The DNA microarray test uses a 70-gene expression signature consisting of genes regulating cell cycle, invasion, metastasis, and angiogenesis to assess risk of recurrence in ER-positive or negative, stage 1 and 2, lymph-node negative women under age 61. To Agendia's credit, MammaPrint is the first device approved under FDA's controversial new in vitro diagnostic multivariate index assay (IVDMIA) classification (CLN, March 2007). The FDA initially approved the test for use on frozen samples analyzed in Agendia's Amsterdam labs; however, in June, FDA granted the company a second approval for use of fresh samples preserved in a special solution and sent to the company's lab. In its decision summary, FDA notes that the assay is indicated for use only as a prognostic marker, along with other clinicopathological factors.
To assess the global gene expression pattern of a breast tumor sample, Agendia's lab extracts messenger RNA from the sample and labels it with a fluorescent dye. The labeled mRNA, together with the labeled mRNA from a reference sample, is hybridized to the DNA microarray. The customized arrays also contain several hundred carefully selected normalization genes. Finally, negative control genes are present on each microarray; these are DNA sequences to which human mRNA does not hybridize and that are used to monitor various technical aspects of the microarray process. Results are available within 10 working days of sample receipt, according to Agendia's Web site.
The MammaPrint validation study (Journal of the National Cancer Institute 2006; 98: 1183–1192) divided 307 patients into high- and low-risk groups based on their gene signature and clinical risk classifications—with 137 events after a median follow-up of 13.6 years by five European centers. Patients were assigned to the gene signature low-risk group if their 5-year distant metastasis-free survival probability as estimated by the gene signature was greater than 90%. Patients were assigned to the clinicopathologic low-risk group if their 10-year survival probability, as estimated by algorithm software from Adjuvant! Online, was greater than 88% for ER-positive patients and 92% for ER-negative patients. Researchers from 39 European institution members of the TRANSBIG Consortium found that the signature outperformed the clinicopathologic risk assessment in predicting all endpoints. The FDA summary for MammPrint notes that MammPrint's clinical performance has been supported by three other prior studies that used TRANSBIG data.
The tests' technologies and validation cohorts raise many issues, noted both Genomic Health and Agendia officials. Gary Palmer, MD, Genomic Health's Senior Director of Medical Affairs pointed first to predictive data. "Most importantly and unlike any other tests, Oncotype DX has a predictive component as published in the Journal of Clinical Oncology in 2006." Then there is the practical matter of the tumor sample itself. Oncotype's use of paraffin-embedded tumor samples reflects most U.S. hospitals' collection methods, whereas MammaPrint's use of fresh samples would present difficulty at many institutions, Palmer noted "There's no other test done on fresh tissue at most community hospitals," he said, noting that most institutions are not set up to collect it.
But Rene Bernards, Agendia's Chief Scientific Officer, regarded his company's use of fresh tissue as a strength. "Each tumor starts fresh. Paraffin embedding used to preserve tissue is a technique that dates to the nineteenth century. It's not the wave of the future." He predicted that as genomic tests become more common, paraffin embedding will become "a thing of the past" because it degrades RNA. "FDA approval takes into consideration how you ensure RNA quality," he said. "The bottom line is yes, paraffin is more convenient. The question you need to ask yourself as a scientist is whether to go for accuracy or convenience."
Genomic Health has taken measures to ensure RNA quality in its assay, Palmer asserted. Oncotype "was optimized to measure RNA fragments found in formalin-fixed, paraffin-embedded tissue and the assay includes reference genes that essentially measure the amount of RNA degradation, since all specimens are not the same with respect to fixation," he explained. Research by the company shows that the assay's five reference genes both compensate for sample variation in extracted RNA attributable to the tissue fixation process and normalize expression of the 16 cancer-related genes prior to calculation of the recurrence score (Clinical Chemistry 2007; 53: 1084–1091).
Which patients may potentially benefit from the test is another key issue to consider. According to Palmer, Genomic Health's test is designed for ER-positive patients. "Since these women are likely to respond to hormone therapy like tomoxifen or aromatase inhibitors, oncologists often have trouble deciding whether additional chemotherapy is necessary. This situation makes a test geared for ER-positive women valuable," he explained. "MammaPrint's validation studies didn't separate out ER-positive and ER-negative patients. Physicians really question how to treat ER-negative patients." A substantial number of breast cancer patients are also older than 61 and would not benefit from MammaPrint, he added.
According to Bernards, MammaPrint's FDA approval confers a major advantage. "FDA looked at our data more deeply to make sure it agrees with the claims we make. So clinicians know the test is based on solid science. Physicians with no insight into the details of a (reference lab's) test will have difficulty knowing if the claims are sufficiently founded. The dilemma for physicians is whether to wait for prospective validation (of MammaPrint) or to go with our test based on its FDA approval."
More Gene Profiling Assays for Breast Cancer
Lab directors and oncologists considering gene profiling assays to help determine risk of recurrence or tailor treatment of breast cancer patients have an expanding list of options to consider. In addition to the Oncotype DX (Genomic Health, Redwood City, Calif.) and MammaPrint assay (Agendia, Amsterdam, Netherlands), other tests are available or forthcoming.
The Users Weigh In
Pathologists and oncologists interviewed for this article generally viewed gene expression profiling tests as promising, but their varied opinions about Oncotype and MammaPrint show that profiling tests haven't achieved widespread acceptance. Some of the physicians emphasized that they still consider the tests secondary to traditional markers used to determine risk of recurrence but prefer Oncotype for its use of paraffin embedding and its predictive ability, while others preferred MammaPrint for its larger number of genes and use in both ER-positive and negative cancers.
"Personally, I'm a skeptic about these sorts of tests in general," said Pins. "I need to see good, solid prospective data." Pins prefers Oncotype over MammaPrint because getting fresh tissue "is a laborious process with little standardization between sites." Richard Bender, MD, Medical Director, Hematology and Oncology at Quest Diagnostics' Nichols Institute in San Juan Capistrano, Calif.—which markets its own gene profiling test— agreed that using fresh tissue is a downside to MammaPrint. "It's not based on the way we practice medicine here in the U.S," he maintained. David Hyams, MD, National Director of Clinical Research for Aptium Oncology, Inc. (Los Angeles, Calif.), Medical Director of Surgical Oncology at Comprehensive Cancer Center at Desert Regional Medical Center in Palm Springs, Calif., and a consultant to Genomic Health, explained that with paraffin-embedded tissue, "You don't have to make a decision about an assay before a patient comes to surgery."
Oncotype provides more information about a tumor than does MammaPrint, in Hyams' opinion. "Oncotype tells you more about the biology of tumors, while MammaPrint basically tells you only if a patient is at high- or low-risk. It doesn't rank patients, whereas Oncotype does." He added that although MammaPrint looks at more genes, it gives less information about each one because it uses microarrays rather than PCR. "It can't tell you the degree to which a gene is over or under expressed. It tells you if a patient if at low or high risk of recurrence, period. It doesn't say how high," he explained. Hyams also prefers Oncotype because it provides predictive information, and he considers the assay more rigidly validated than MammaPrint.
Pathologist Neal Goldstein, MD, Director of Advanced Diagnostics and the Molecular Oncology Lab at William Beaumont Hospital (Royal Oak, Mich.) said he looks to the future and the availability of more data on gene expression profile assays, but in the meantime, he prefers MammaPrint because it's applicable for both ER-positive and negative cancers. He's concerned about the current lack of standards for determining if samples are ER positive. "What's considered positive in one institution may not be in another. So if you're using Oncotype, there's a question regarding the stringency of what you're selecting for and who is eligible for the assay." Genomic Health's Palmer agreed that determination of ER status varies from hospital to hospital, but he maintained that despite any irregularities, oncologists must make decisions about treatment based on ER status, whatever a hospital's methods or quality assurance.
Another reason for Goldstein's preference for the MammaPrint test is that it encompasses many more genes than the Oncotype test. "The clinical utility of assays using smaller numbers of genes is dubious in my opinion. Cancers are complex, and oncologists are trying to identify not only the genes involved, but also what signaling pathways are being disturbed by being turned off or on by the cancer. Therapy must match those alterations." That said, Goldstein noted that William Beaumont hospital oncologists most often order the Oncotype test to convince reluctant patients to undergo chemotherapy. "It appears that nobody withholds chemotherapy based on a low recurrence score," he commented.
The Ethnicity Question
Gene expression tests may be more useful in smaller community hospitals, but decisions must take into account the ethnicity of particular patients and validation cohorts, according to Philip Bernard, MD, Assistant Professor in the Department of Pathology at the University of Utah in Salt Lake City. He is now preparing a 510(k) submission for a new prognostic test he hopes ARUP Labs (Salt Lake City, Utah) will offer sometime in 2008. "There's a place for multianalyte tests. They may be more useful for oncologists in community institutions that don't have access to a panel of experts like their counterparts in academic medical centers. But it's important to be aware of whether the patient is similar to the assay validation cohort. All of these tests are better validated in Caucasians than in other ethnic groups," he advised.
Allen M. Gown, MD, Clinical Professor of Pathology, University of British Columbia (Vancouver, Canada), and Medical Director and Chief Pathologist, PhenoPath Labs (Seattle, Wash.), which is participating in a study of the Oncotype assay, has another view. "Is Oncotype giving us information we don't already have?" he asked. "There are other ways to stratify patients, and many are part of the genes examined by Oncotype. But Oncotype is more accurate and standardized than immunohistrochemistry. If the test only gives numbers that are accurate and reproducible, instead of novel, that may be enough to make it worthwhile. If you get better, more reliable numbers, it's worth the price, especially if insurance pays," he asserted.
The Bottom Line: Useful Information
Whatever their preference for a certain assay or opinion about gene expression profiling tests in general, these clinicians and lab directors agreed that the bottom line on using the gene profiling tests is whether they yield useful information. "The issue is whether stratification of risk and related change of treatment affects outcomes. What's important isn't so much stratifying risk but showing that the information allows change of intervention that reduces recurrence," summarized Nichols Institute's Bender. "The problem is that there's still a number of younger patients who are ER positive, node negative, and with slightly higher grade cancers who are concerned that hormone therapy is not enough. If there's a high likelihood that cancer will recur, that information will help them make an informed decision about chemotherapy."
A Long Wait for More Data
Data from large, ongoing studies may provide better insight about using the information provided by the Oncotype and MammaPrint tests and aid in choosing a test, but trials won't conclude any time soon. Preliminary prospective data on the benefit of chemotherapy to women with intermediate Oncotype risk scores won't be available until at least 2013, according to Joseph A. Sparano, MD, Professor of Medicine and Women's Health at Albert Einstein College of Medicine, Director of the Breast Evaluation Center at the Montefiore-Einstein Cancer Center (Bronx, N.Y), and chair of the National Cancer Institute-sponsored TAILORx trial. Started in April 2006, the trial will enroll 10,000 women with ER-positive, HER2-negative, node-negative breast cancer tumors ranging from 1.0–5 cm or 0.5–1.0 cm with unfavorable histologic features.
Preliminary prospective data for the MammaPrint trial is a minimum of 5 years away, according to a recent newsletter published by the Treatment of Cancer and the Translational Research Breast International Group (TRANSBIG), which is conducting The Microarray in Node Negative Disease May Avoid Chemotherapy trial (MINDACT) with support from the European Organization for Research. The trial will compare MammaPrint with predictions of recurrence risk made by the Adjuvant! Online algorithm using such factors as patient age, tumor size, nodal involvement, and histologic grade. MINDACT aims to enroll 6,000 women, and has thus far enrolled 67, according to the newsletter.
Palmer and Sparano maintained that the two trials ask different questions. While MINDACT is a validation trial to determine if the assay works, TAILORx assumes OncoType DX works and is using it as a tool to assign treatment, as well as whether women with mid-range risk scores need chemotherapy, they said.
A collaboration between the research groups performing the two trials is in the works. In an attempt to perform a cross-validation between the two trials and their tools, TRANSBIG recently decided to collect 100 frozen samples from selected U.S. centers for inclusion in MINDACT. If all goes well, certain U.S. centers will give TRANSBIG 100 samples, both frozen and paraffin-embedded.
While lab directors and oncologists are divided on the current utility of these assays, Hyams believes they represent "the dawn of a new age" in breast cancer treatment. "These are the 'Model Ts' of gene profiling assays. Ultimately, we will get a variety of gene panels that will help us understand the particular disease and customize therapy."
Download the entire issue


text:
another_jim wrote:If the coffee is poor, this might be a good idea. For instance, I think one of the reasons the Nespresso system produces fairly pleasant and understated shots (but not good ones), is that it brews at these lower temperatures. But for good coffees, you are leaving out all the the things which differentiate great coffees from mediocre ones.
lalinpv wrote:Dustin, I agree with tasting more florals when using lower temps. They are interesting brews huh?


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his cover of freaky girl really got on my nerves, but now i can't stop listening to it. but it's not good.. anyways.
EMMA. fuck yeah, lets figure out how we're gonna play some stuff live, start promoting, i'll make a flyer, and maybe we can drive around one day and put them EVERYWHERE. that'd be cool. i'm not going anywhere! so yeah :) let's hit that up!
haven't showered in over a week. gonna go fix that in a sec. but i wanna make a new mix cd first. which could take a few hours. hahah fail.
emma i wanna cover some weird shit. i dunno. and boy who blocked his own shot, i wanna cover that sometime maybe. and something ghetto, that i have yet to come up with.
UHHHH. still got that crazy paper to write! i'm a faillllure.
edit: http://www.youtube.com/watch?v=QhwQay4QiOw
^cover that? but make it sound way different, just the same words?


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Day #42
For our second Elements shoot we have decided to do Water. We figured Air takes up the most volume on the planet, and second to that is Water, which covers 70.78 percent of the Earth's surface, or about 139.4 million square miles (what what!!). While my depiction of water cannot possibly come close to the dramatic effects that water has, such as rain storms, ocean waves, floods, tsunami's, humidity, hydration (and on and on) I wanted to create something that elegantly depicted its sparkling beauty. Since most of the water on the planet is in the ocean, I was inspired to include a ship and a Japanese influenced wave, which I covered in beading :-). I was very excited about how this hat turned out, as I feel it is very different from my normal creations. Ahoy matey!- Sylva
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The public health and safety experts spun a shocking scenario arising from the threat of an avian flu pandemic from Asia: 12,000 deaths in the state early on, with the possibility of many more later.
More conservative estimates from the U.S. Centers for Disease Control and Prevention suggest 1,600 to 3,700 Maryland deaths and 16,000 hospitalizations. But public health leaders can't be optimists.
"We have to plan for the worst-case event," said Dr. Jean Taylor, who heads Maryland's pandemic-planning efforts at the state Department of Health and Mental Hygiene.
To safeguard Americans against a pandemic that scientists generally agree is inevitable, federal, state and local officials are developing extensive plans encompassing needs such as hospital and mortuary capacity and production of antiviral medication and vaccines. Local health departments have begun identifying locations such as school gyms and community centers that could accommodate temporary hospitals -- space that might be needed for months.
This month, President Bush signed an executive order authorizing use of quarantines for avian flu cases.
Despite the enormous efforts, critics are warning that the federal government hasn't done enough. Among them are Andrew Pavia, chairman of the Infectious Diseases Society of America's task force on pandemic influenza. He told Congress late last month that "the United States is woefully unprepared for a pandemic that might occur in the next few years."
Antiviral drugs like Tamiflu are essential tools in slowing the spread of disease until a vaccine can be developed to immunize people -- a process that can take six to eight months from the time a killer virus is identified. The United States has enough Tamiflu on hand to care for 2.3 million people, significantly less than some other nations.
But federal authorities said substantial progress is being made:
This summer, the National Vaccine Program Office will finalize a Pandemic Influenza Preparedness and Response Plan. State health departments are expected to have their plans ready by September.
But there's only so much the government can do to prepare.
Despite years of worry about an avian flu outbreak in Asia, virologists don't know for sure which virus they would face in a pandemic, where it would evolve, how deadly it will be or how easily it would be passed from person to person.
Pharmaceutical manufacturers can't begin making vaccines until that new virus emerges. Even then, they'll need months, while the disease is spreading, to grow the vaccine proteins in fertilized chicken eggs.


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FORT WORTH — The state's main power grid narrowly avoided outages on Monday after several power plants failed as electricity demand soared in response to the coldest weather in two years.The Electric Reliability Council of Texas, which manages the power grid that serves most of Texas, briefly issued an Energy Emergency Alert 2 early Monday morning, the last step before rotating power outages would be implemented. ERCOT canceled the warning about possible outages shortly after 9:30 a.m. But the loss of just one more large power plant could have pushed the grid over the edge, Dan Woodfin, ERCOT director of system operations, told reporters during a conference call. The grid lost two big power plants to weather-related problems and some others to other problems, totaling about 3,700 megawatts of power, Woodfin said.During that time, the state imported about 800 megawatts from the nation's eastern power grid and 180 megawatts from Mexico. A megawatt is enough to supply about 200 Texas homes during a period of peak usage and about 500 homes during routine usage.As the Arctic air settled in across North Texas on Monday morning, temperatures plunged into the teens and wind chills dropped to the single digits.At Dallas/Fort Worth Airport, the low was 15 degrees, the coldest since the ice storm during Super Bowl week in February 2011. On Feb. 2, 2011, the temperature dropped to 13 degrees and on Feb. 10, 2011, it dropped to 15. The overnight low was 19, and Tuesday's high is expected to be in the mid-40s.While Monday's low was not a record-breaker — that came in 1912 when it got down to 11 degrees — it hadn't been that cold on Jan. 6 since 1924, when it also reached 15.Alliance Airport dropped to 10 degrees shortly after 7 a.m. Monday and recorded a wind chill of minus 1. At D/FW Airport, the coldest wind chill recorded was 1 degree above zero.This was still far warmer than the coldest temperatures on record for the Dallas-Fort Worth area. On Feb. 12, 1899, the temperature dropped to minus 8 degrees. It reached 2 below zero on Jan. 31, 1949, and it has reached minus 1 twice, most recently on Dec. 23, 1989.Temperatures were back in the teens Tuesday morning across North Texas, and concerns about energy consumption continued as some parts of the state including Houston were expected to see lower temperatures than Monday. No outages were reported early Tuesday.Better prepared for coldPower demand in Texas peaks during the summer as air conditioners fire up. But about half of Texas residences use electricity rather than natural gas for heat during the winter, and electric-resistance furnaces are especially energy-hungry.Even though ERCOT avoided outages Monday, power companies paid hefty prices to buy electricity during the emergency alert period, when wholesale prices for one hour topped the state's regulatory ceiling of $5,000 per megawatt-hour, Woodfin said. That's about 100 times the $50 per megawatt-hour price generally seen.The state Public Utility Commission has been raising the ceiling in an effort to encourage generators to build more plants to meet growing demand. Prices can sometimes exceed that ceiling after additional costs related to moving the power on the grid are included.ERCOT said demand for electricity Monday reached 55,486 megawatts between 7 and 8 a.m. That's short of the record winter demand of 57,265 megawatts on Feb. 10, 2011, which produced rotating outages, and also lower than peak demand during last month's run of low temperatures, ERCOT spokeswoman Robbie Searcy said.But just as in 2011, some generators were incapacitated by the cold on Monday, although not nearly as many. The two big North Central Texas plants that went down "both were related to freezing of instrumentation used to provide control of the plants," Woodfin said. The units were not identified.Woodfin said ERCOT and Texas regulators implemented "best practices" standards for weatherization of power plants after the 2011 outages, and he thought the relatively few generators with problems Monday showed that the state had improved its ability to avoid cold-related problems. Among the changes: requiring effective insulation, heaters and wind screens to protect sensors and hydraulic lines needed by power plants to operate.Luminant spokesman Brad Watson said Monday that "all available Luminant power plants were operating this morning, and we're not aware at this time of weather impacting generation." He said the company does not comment on operations at specific plants, although he did say output at Comanche Peak was reduced at one of its two nuclear reactors.ERCOT asked residents to set their thermostats no higher than 68 degrees and turn off and unplug nonessential lights and appliances. It was also advising individuals not to run large appliances such as washers, dryers and electric ovens during peak hours — 6-9 a.m. and 4-8 p.m. Businesses are also advised to minimize the use of electric lighting and electricity-consuming equipment as much as possible.About 300 customers remained without power Monday evening in Burleson as a result of an equipment failure, a company spokesman said. Warmup comingThe frigid weather this winter across much of the U.S. can be attributed to a dip in the jet stream that has brought cold air south across the Midwest and down into Texas. But National Weather Service meteorologist Jesse Moore said it's having implications beyond the U.S."The jet stream has basically dived southeast of the Rockies and it heads back north off of the East Coast," Moore said. "They've been getting big storms in the United Kingdom. We've gotten the cold air here, but the jet stream pushes back up north toward Europe, giving them warmer, windier weather."The Arctic air is expected to give way to milder weather the rest of the week. Highs in Dallas-Fort Worth should be in the mid-40s on Tuesday, the 50s on Wednesday and back in the 60s on Friday. Forecasters are also predicting a chance of rain from Wednesday through Saturday after the freezing temperatures have left the area."We actually start warming up tomorrow, but it will be more noticeable on Wednesday," Moore said.
Subzero "polar vortex" pushes frigid air across U.S.
Forecast, radar for North Texas
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posted this on November 06, 2012 14:22
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Maura Reilly
Richter Swap: Pace Foundation Managers Sell Painting To Fund New Art Campus
By Bill Davenport on October 19, 2014
Buried in a recent newsletter from the Linda Pace Foundation is the news that the foundation plans to auction off Gerhard Richter's Abstraktes Bild (774-4), […]
Posted in Newswire | Tagged daniel adjaye, gerhard richter, kathryn kanjo, Linda Pace Foundation, Maura Reilly | 3 Responses
Linda Pace Foundation Appoints Interim Director; Will Launch International Search For New One
By Christina Rees on August 15, 2014
News from San Antonio: The Linda Pace Foundation (or LPF, the umbrella foundation responsible for the artist residency ArtPace as well as grants, scholorships, public […]
Posted in Newswire | Tagged arts consulting group, Kathryn R. Martin, Linda Pace Foundation, Maura Reilly | Leave a response
SPACE Ready to Open Private Collection to the Public
By Lucia Simek on April 6, 2014
On April 18, San Antonio's Linda Pace Foundation will open SPACE, an exhibition space designed by San Antonio architect Jim Poteet, FAIA, which will house […]
Posted in Newswire | Tagged Artpace, Linda Pace Foundation, Maura Reilly, SPACE | Leave a response
Maura Reilly Leaves Linda Pace Foundation
By Scott Andrews on March 28, 2014
The Linda Pace Foundation confirmed today that Executive Director Maura Reilly is no longer with the San Antonio arts nonprofit. Details of her departure have […]
Posted in Newswire | Tagged Linda Pace Foundation, Maura Reilly | 1 Response
Pace Foundation to Unveil First Public Artwork, and It's a Big One
By Paula Newton on December 10, 2013
Later this month, the Linda Pace Foundation will present its first public artwork, Adam, by Arturo Herrera, which will be located opposite to San Antonio's […]
Posted in Newswire | Tagged Arturo Herrera, Linda Pace Foundation, Maura Reilly, San Antonio public art | Leave a response
Maura Reilly's Pace Plans
By Scott Andrews on November 17, 2013
Maura Reilly, the new Executive Director of the Linda Pace Foundation, has been at the helm of the San Antonio foundation for three months now. […]
Posted in Blog, Uncategorized | Tagged alejandro diaz, Linda Pace Foundation, Maura Reilly, sala diaz, San Antonio, tracey moffatt | Leave a response
Pace Foundation Names New Director
By Paula Newton on June 12, 2013
The Linda Pace Foundation in San Antonio has announced the appointment of Dr. Maura Reilly as its new Executive Director. The New York- and Sydney-based […]
Posted in Newswire, Uncategorized | Tagged Artpace, Linda Pace Foundation, Maura Reilly, San Antonio arts | Leave a response


text:
White Smoke
Edit Page Last Edit: 2 years ago
White Smoke is an Ability which prevents enemy Pokemon from decreasing the user's Stats. The user can still decrease its own stats through specific moves, however.
Outside of battle, place a Pokemon with White Smoke in the lead of the party to encounter wild Pokemon 50% less often.
What Links HereAbilities | Mold Breaker
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Posts tagged with 'stoweboyd.com'
Recalibrating my Tumblrs
I've decided to go back to writing about some of my interests at underpaidgenius.com, again, like politics and the arts. And stoweboyd.com is becoming a commonplace book for my futures interests: tech, cognition, design, organizational culture, futures in general, like the future of work, and economics. I tried to collapse those two sides of my interests into one place for a while, here at stoweboyd.com, but I think it doesn't work as well that way for others, or for me, either.
Taking Down Disqus Comments
I am finding that Disqus style comments are increasingly out of step on Tumblr. The overwhelming majority of interaction here is native Tumblr reposting, likes, and replies.
If you are a Tumblr non-user, I suggest you get an account and try it. Here's a post where I describe how rich the 'inside view' is at Tumblr.
If you'd like to chat with me about something posted here you can try @stoweboyd on Twitter, click on the 'contact me' or 'ask me anything' in the right hand margin.
Turn And Face The Change
Writing at GigaOM Research has started to have a collateral impact in a far corner of my world. I am directing a great deal of my most mainstream social business and future of work writing there (and enjoying it), much of which would have appeared here, at stoweboyd.com. And as I have started to accept the fact that I can't write at any depth about where the social revolution is headed without a larger scope — including design thinking, economics, cognitive science, and social criticism — more of what used to appear in underpaidgenius.com is showing up here.
As an obvious case in point, I wrote Debunking Compulsory Coupledom here the other day, which even a few weeks ago I would have posted at underpaidgenius.com.
I have to face it: underpaidgenius is becoming significantly less important to me, and looks destined to become a combination recipe box and travel diary, with an occasional poem or political rant.
What I Write About, And Where
I am going through a shift in the focus of my various writing projects, primarily because of the new role I've taken on at GigaOM, as a curator in the Social channel. So, a great deal of my analysis on tools and techniques for social business will be showing up there, with regular links and a monthly update here at stoweboyd.com. Other topics at stoweboyd.com will include basically all the topics that I think impinge on what I am calling the Postnormal economy: technology, economics, business, science, and futures in general. My other interests — principally culture and politics — are found as always at underpaidgenius.com, and there is the special case of beaconstreets.com, where I advocate for a more walkable Beacon, NY, the city where I now reside.
5000th post at stoweboyd.com
Most Popular Posts Of 2011
Just looking back at the year's posts, and here's what people read the most on stoweboyd.com:
- What Twitter Could Learn From Tumblr
- Teens Hate Email
- Google+ Is Worse Than A Ghost Town, It's Not Even Haunted
- Messiness At Scale
- 56% Of Young Professionals Won't Work At A Company That Bans Twitter And Facebook
- Tumblr Is Crushing Wordpress, And Stealing The Future
- You Are Who You Follow
- Liquid Email
- The Facebooking Of Identity
- Why I Am Not Going To SxSW
- The Collapse Of The Complex: Why Facebook Will Fall
- Revolution = Messiness At Scale, Again
- The Rise Of Rōnin and The Liquid Economy
- Life As A Mosaic, Not A Monolith: What Google+ Means
- The Fall Of Mass Culture, The Rise Of Meaning
Some oldies from earlier years saw some reasonable traffic this year, as well:
- Web 2.0 Expo Meeting Scheduling: Twitpitch Me! [April 2008]
- Are You Ready For Social Software? [January 2005]
- The False Question Of Attention Economics [January 2010]
- It's Betweenness That Matters, Not Your Eigenvalue: The Dark Matter Of Influence [February 2010]
- Why I am Going To Leave Squarespace [June 2010]
I left out things that I didn't write, but I was just pointing to. The biggest post of the year falls in this category: Map Of A Tweet, which went viral although I simply posted the image.
Year-end posts get a bad deal in this year-at-a-time retrospective, so here's a few of the most popular in the past months that didn't make it into the top 15:
- The Famous Are Different From You And Me
- Graph Rank: Just Another Proof That Facebook Should Be Boycotted
- Rising Use of Consumer Technology in the Workplace Forcing IT Departments to Respond, Accenture Research Finds
- The End Of An Age, Or The End Of The Beginning?
- Staff to be banned from sending emails
- Why Apps Are The Future
- A Prediction: IBM And Microsoft
- Facebook Is The New Suburbia
- Learning From The Google+ Experiment: Operating System, Platform, Apps
- The Myth of Monotasking - Cathy Davidson via HASTAC
Going Back To Two Blogs
After experimenting a few days with collapsing everything I blog onto stoweboyd.com, I have decided that I am too set in my ways, and I'll go back to posting politics, economics, and so on back on underpaidgenius. I may do a lot more cross posting in the future, though.
Twitter Shakes Things Up Again: Fred Wilson, Bijan Sabet Leaving Board - Peter Kafka - Social - AllThingsD →
More turnover as Costolo marches out more of the old guard at Twitter, turning early stage investors out, after making room for seasoned entrepreneurs like David Rosenblatt and Mike McCue last year.
China Consolidates Control of Rare Earth Industry - Keith Bradsher →
China produces nearly 95 percent of the world's rare earth materials, and it is taking the steps to improve pollution controls in a notoriously toxic mining and processing industry. But the moves also have potential international trade implications and have started yet another round of price increases for rare earths, which are vital for green-energy products including giant wind turbines, hybrid gasoline-electric cars and compact fluorescent bulbs. General Electric, facing complaints in the United States about rising prices for its compact fluorescent bulbs, recently noted in a statement that if the rate of inflation over the last 12 months on the rare earth element europium oxide had been applied to a $2 cup of coffee, that coffee would now cost $24.55.I read in Wikipedia that rare earths are distributed globally, but it will take years to build up the infrastructure to process them in reasonable quantities.
This Is My 3400th Post Here
stoweboyd.com has been my blog for just a year, but I imported over (nearly) all my old posts from /Message in 2010, and a bunch but not all of the posts from Get Real back in 2006, and I had ported a bunch of the Timing posts back in 2004 into that. I even have posted my old columns from Darwin, but there's only 6 or 8 of those. My original blog, in 2000, was Message From Edge City, which was shut down one day when my hosting service, convey.com, was closed down. I saved a few posts, but restarted on Blogger in 2004, with Timing.
Still, it's a lot of wordage. And a lot of yearage. 3400 posts, 12 years, and counting.
Thank you, folks. It's been an honor, and I ain't done yet.


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The closest park is Acton State Park.
Nearby schools include Acton Elementary School, Acton Elementary School and Creations Child Care & Learning.
The closest grocery stores are David's Supermarket, Health Nutts and Triangle Grocery.
Nearby restaurants include Golden Chick, Pam's Too and Sonic Drive-In.


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NPSF videos and slideshows are available here, including the Patient Safety Awareness Week video, updated for 2012.
Patient Safety Backgrounders for Reporters
Need a basic grounding in patient safety for your story? Check some of our resources here.


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Abandoned Places That Look Truly Beautiful
16 People Fortunately Saved from Their Horrible Tattoos
18 Cute Girls Gone Ugly
Controversy Over New Steroid Alternatives
25 Things You Probably Google When You're All Alone
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Lion Does the Most Unexpected Thing When Someone Unlocks Her Cage
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Doctors Inject HIV Into Dying Girl: You'll Be Glad They Did
The Human Barbie's Makeup Free Selfie Will Shock You
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Hot Women Of The World Cup
Man Skips Rocks on Frozen Lake & Gets the Surprise of a Lifetime!
Hippo vs Crocodile Standoff: 7 Crazy Pics
15 DIY Projects for Your Man Cave
The 50 Funniest Photos of 2014... So Far
46 Perfectly Timed Photos You'll Have to Look Twice to Understand.
What If You Saw Someone Doing This at the Airport?
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Celebrities Before and After Photoshop
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Little Girl Born With 'No Blood' Defies All Odds
Prepare to Have Your Mind Blown
The 25 Worst Spray Tans You'll Ever See
The 6-Inch Alien's Checkered Past


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Samuel Hinsdale
Class of 2015
Mayeesa Mitchell
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James Ensor
Class of 2017
Ashley Gable
Class of 2017
HIGH POINT, N.C., Aug. 22, 2013 – High Point University's English department recently hired Dr. Adrian Greene as their new instructor of English.
He will teach two composition courses and two courses in American Gothic literature, but his teaching won't stop there.
"I believe the mentor and adviser relationship is one of the most important duties of a professor," says Greene. "I consider it an honor to get to know my students not only through their writing but through interpersonal connections as well."
Greene received his Bachelor and Master of Arts degrees in English from Wake Forest University and his doctorate in English from the University of North Carolina at Chapel Hill.


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Star Jones POPS BACK At Anderson Cooper's Verbal Smack Down Over "Coming Out" For Ratings
Star Jones, the woman who basically used a majority of one season of "The View" to pimp free ish for her wedding to Al Reynolds (we won't even address the irony of who she married), has accused CNN anchor & talk show host Anderson Cooper of coming out just for ratings. And after his verbal smack down of a response yesterday Star is still talking.
Deets inside...
To bring you up to speed, Anderson Cooper snapped back at Star Jones yesterday on his "Anderson Live" show for hypocritically accusing him of being a publicity whore. If you already didn't love the silver fox...you will now.
Here's the clip and what Anderson said:
That's why it so annoyed me because of all the ways to boost ratings, like if I was wanting to boost ratings I would have waited to announce it on a very special episode, that would have been promo'd for weeks and weeks and there would have been commercials, 'Anderson's huge announcement,' and you would have a cut away of the audience but instead I was in Africa on assignment for 60 Minutes, I sent an email to a friend of mine who put it on a website. I gave no interviews about it, I never talked about it.
I wasn't even on the air for days afterward and so suddenly Star Jones, who as memory serves, in terms of boosting ratings, I seem to recall her hocking her wedding every single day to get free products when she was on The View and I seem to recall her lying about her gastric bypass surgery and making everybody else lie about it as well. So for her to suddenly emerge out of the shadows and suddenly attack me for this, I couldn't believe it. And my mom was like, 'Who is Star Jones?' Anyway, so I can't even believe I am bringing this up because I don't even want to give Star Jones the attention. I never planned on talking about this but we invited Star Jones to come on this show and she turned us down.
Star, who possibly tweeted this response based on feeling embarrased for getting read by Anderson Cooper, said this afterwards:
I was wrong. @andersoncooper didn't come out as a ratings ploy. He used ME talking about him coming out @todayshow as a ratings ploy. #mybad
Sounds a bit arrogant and doesn't make much sense. We doubt Anderson would have ever brought up your name had you not said anything in the first place. So using your name for ratings is just silly. And he does have a right to defend an accusation...especially on his own show. We always had our side eye place on Star Jones, and now it's widened a bit.
Its funny to me how this
8:42 pm - Oct 5, '12
Star Jones is no stranger to
5:41 pm - Oct 6, '12
Star...girl stop it. What a
7:42 pm - Oct 5, '12
STAR...have SEVERAL of them
3:13 pm - Oct 5, '12
Dear Star, It's way more than
1:58 pm - Oct 5, '12
While I'm sure she thinks the
1:43 pm - Oct 5, '12
Girl what you said is the
5:26 pm - Oct 5, '12
Love Star but she spends too
1:39 pm - Oct 5, '12
Preach Star. Theses public
1:31 pm - Oct 5, '12
Where in Anderson Cooper's
5:26 pm - Oct 6, '12
Everybody's feuding...what is
12:55 pm - Oct 5, '12
Star, that fur coat though.
12:39 pm - Oct 5, '12
she's the one trying to stay
12:36 pm - Oct 5, '12
"fallen star" you people.
12:36 pm - Oct 5, '12
sadly, My boyfriend and me
12:35 pm - Oct 5, '12
Starruh, if you don't sit
12:28 pm - Oct 5, '12
Nene come get Star. She
12:19 pm - Oct 5, '12
Star better have a seat.
12:04 pm - Oct 5, '12
Give it up Star. Learn to
12:02 pm - Oct 5, '12
11:59 am - Oct 5, '12
Look who is talking about
11:55 am - Oct 5, '12
Star may be the one looking
11:58 am - Oct 5, '12
Fallen Star Jones and Cray
11:45 am - Oct 5, '12
I love Anderson!!!!! Why did
11:47 am - Oct 5, '12
C,mon now Star, Coop using
11:40 am - Oct 5, '12
11:44 am - Oct 5, '12
HAHAHAHAHA #dead
11:50 am - Oct 5, '12
Star dont want it with
11:30 am - Oct 5, '12


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Danisco Sugar A/S is a recipient of farm subsidies in København K, Denmark.
Since 2010 Danisco Sugar A/S has received € in payments from the European Union .
People have been helping us to find out more about Danisco Sugar A/S. You can add more information below. Here is what we know so far:
HuberAdded 2 February 2011 by Gmeiner | # | something wrong?
Can you find any more information about Danisco Sugar A/S? Is it a multi-national company of a small independent farm? What does it produce? Is it a subsidiary of a larger company? How large is it? Is it owned by anyone noteworthy?
Create an account or sign in to tell us something about Danisco Sugar A/S.


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WFPL News
9:30 am
Mon February 25, 2013
Budget, Gaming Bills Among Many Moving Through Indiana Legislature
A state budget and measures affecting schools and the gaming industry are on the long list of proposals still to be considered by the Indiana General Assembly.
The budget being crafted by GOP lawmakers who control the House does not include an income tax cut pushed by fellow Republican Gov. Mike Pence, but they say they'll revisit Pence's proposal after getting an updated economic forecast in April.
The plan would instead use the tax cut money to boost spending on education and transportation.
Among the bills awaiting action in the full Senate is a plan aimed at helping the state's gaming industry compete with new casinos springing up in surrounding states, and a proposal to spend $10 million on school safety initiatives.
Lawmakers are also debating a proposal by Governor Pence use the existing Healthy Indiana Plan to expand Medicaid coverage in the state.


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According to experts at Hofstra University, sex abuse against minors is '100 times worse' in public schools. With that in mind, it's easy to see what the root agenda is for the media, the liberals (who control it), and the U.N..
The committee, for example, urged the Vatican to amend its canon law to identify circumstances where access to abortion can be permitted for children, such as to save the life of a young mother. It urged the Holy See to ensure that sex education, including access to information about contraception and preventing HIV, is mandatory in Catholic schools. It called for the Holy See to use its moral authority to condemn discrimination against homosexual children, or children raised by same-sex couples.
Meanwhile, followers of mohammed can enslave, murder, destroy, and behead Christians while demanding the world submit to sharia law. The United Nations will ignore and cover for such TRUE abominations because they are typical, cowardly liberals.
Now it's time to sit back and pray while waiting for a response from GOD ALMIGHTY. You see, not too long ago the United States relentlessly harassed the Vatican. Such intimidations and threats were followed by an incident which strongly resembled a plague of Egypt – the Gulf Oil disaster. While this may be a multi-national committee, the United States has also been busy stabbing Israel (diplomatically) in the back.
Keep watch….this has been the moment we've been sadly expecting: the Church brought before a world court and pressured to abandon her beliefs and literally turn away from Christ.
Not gonna happen. But it could get quite ugly with the liberal media propagandists driving a well coordinated hate campaign in league with fascist, communists who hold seats of power.
Make no mistake though…they are foolishly picking a war against Almighty GOD.


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Aunt Karen's Cheesecake
Community Recipe from
- 2 8 in graham cracker crust
- 3 8-oz pakges cream cheese
- 4 eggs
- 1 teaspoon(s) vanilla
- 1 cup(s) sugar
- topping
- 1 6oz sour cream
- 1 tablespoon(s) sugar
- 1 teaspoon(s) vanilla
- Beat until cream cheese is smooth and light. Add eggs and vanilla and sugar. Beat until smooth and creamy. Pour into crusts, bake 30-35min at 350.
- add topping and bake 10 more min.
May 2012
This recipe is a personal recipe added by elizabeth413 and has not been tested or endorsed by MyRecipes.
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Sassy Yoga Challenge Days 27 and 28: Extended Side Angle and Reverse Warrior
In both poses, avoid collapsing into your side body. Focus on lifting up and elongating your spine rather than reaching over as far as you can.
Remember that these are side body stretches, NOT backbends! Roll your top shoulder back to open your heart toward the sky / ceiling and stretch your side.
Stay strong in your lunged leg, and push through the outer edge of your back foot. Send energy into both legs!
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Thursday, July 17th, 2014
Body Language, "4 Real"
Maybe a little too exuberant to play when it's not sunny outside, or, at night, before your guests have gotten to their second drink. Context gives music life, and so context can TAKE IT AWAY. [Via]
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Thank you for the song. I like it


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LEVI3 Wrote:
Jan 16, 2013 11:30 AM
Reading "RANSOM'S RANTS" every morning is fun Years ago I taught Nuclear Power in Admiral Rickover's Navy. We started with students that had an IQ of at least 120 just to enter the program. Most has at least some college. The program was in two parts, academic and an empirical qualification program at an actual reactor. If they passed both phases, the student was then allowed to go to the fleet and qualify on an operating ship or submarine reactor. The amazing part was that our first job in the empirical training was to teach the student to "think for them selves". Academia does NOT teach our kids to think. Sadly witnessed by many of the comments posted. Ransom's common sense sarcasm is refreshing.


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Archive for edtech SmartBlogs
I tend to be one of those educational risk takers.
As a K-12 administrator, I loved nothing more than to visit classrooms where there was a buzz of student learning, where you could stand in the doorway for minutes before anyone even knew you were there, where a room was a hive of student activity, where the teacher was lost in the swirl of investigation and collaboration, where classroom management stemmed from an intensity of engagement rather than the enforcement of rules.[…] Continue Reading »
It is clear that education is going through an evolution/revolution due to technology and open sourcing. Our students have opportunities to do, make and discover things that we couldn't have dreamed of 20 years ago. For some educators, though, this shift can be felt most keenly in the realm of sharing and consuming knowledge and resources online.[…] Continue Reading »
When discussing my classroom cell phone policy with students at the beginning of the school year, I made what proved to be a mistake. I told the students that I wouldn't obsess over policing their phone use in class; after all, smartphones can be powerful tools for learning.
But for the majority of students, I often lost the battle of classroom management and attention despite showcasing and integrating how I — and they — could use a phone to learn, to connect curiosity with knowledge, and complete course assignments.[…] Continue Reading »
SmartBrief on EdTech recently polled readers to discern how well they feel today's schools are using technology to prepare students for college and careers, and to better understand what such preparation might look like. In addition, we wanted to gauge readers' views on the use of massive open online courses — or MOOCs — in the context of higher education.[…] Continue Reading »
Reflecting on the 2013-14 school year, SmartBrief on EdTech polled readers to explore how well technology was used to improve outcomes in student learning and teacher collaboration and find out in what areas schools are making the most progress in effective technology use overall.
Regarding student learning, the results were mixed with just over half of respondents reporting that their school or district used technology either "very well" or "somewhat well" to improve outcomes, while the remainder gave their school or district lower ratings.[…] Continue Reading »


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GENEVA - If there's a common thread among the 170 premieres at this year's Geneva Motor Show, it's sustainable mobility. A press preview, followed by public days March 3-14, kicks off the 81st showing of what has become Europe's top event for automobiles.
Almost every significant new introduction, from Kia's redesigned Picanto -- a city car with CO2 emissions promised to be as low as 90 grams per kilometer, roughly equivalent to 57 U.S. mpg -- to the imposing Phantom 102EX, an experimental all-electric version of the Rolls-Royce flagship, was unveiled with "sustainability," "responsibility," or "technology for tomorrow" as a key theme.
Sustainability is so mainstream at this year's show that the special "Green Pavilion" seems redundant. Rather, the big news was on the main floor. Among the highlights:
- Opel, GM's European arm, revealed the production version of the Ampera, a sibling of the 2011 Chevrolet Volt;
- Ford re-affirmed its strategy to have five new electrified vehicles in Europe by 2013 (and the same number in North America by 2012);
- Nissan and Fiat showed smaller engines that produce the same or better power than the less-efficient versions they replace;
- Toyota showed a prototype all-electric version of its iQ city car, as well as the production model of the Prius+, a seven-seat MPV version of the car that arguably made hybrids mainstream;
- In addition to the over-the-top Rolls-Royce Phantom, claimed to use the world's largest automotive battery -- it alone weighs 1,400 pounds -- the BMW group showed a new version of its ActiveE concept and a truly mini Mini concept called the Rocketman that's closer in size to the 1959 original than the current Cooper and its even-larger Clubman and Countryman cousins;
- PSA Peugeot Citroen announced that it will team with BMW on hybrids and plug-in electric vehicles.
Nearly every automaker has at least one green sub-brand, often using the nomenclature of "eco" or "blue." For example, Kia uses ecoDynamics, Ford has ECOnetic and EcoBoost, Seat claims Ecomotive, and Renault boasts Eco2. From Mercedes we have BlueEFFICIENCY and Bluetec; VW offers BlueMotion, and Peugeot uses Blue Lion to denote its most efficient offerings.
Not to be outdone in the name game, Land Rover showed the concept Range_e Range Rover, a plug-in diesel hybrid version that's said to be sold in 2013. And Skoda, the Volkswagen-owned Czech brand, even changed its logo from what it calls "natural" green to "lush" green -- and its executive team sported matching leaf-colored neckties to celebrate.