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there's at least two more songs on the way
4 walls, 1 window popped up, and were still waiting on at least 2 more :P
4 walls 1 window reminds me of Dog eat Dog, ultraphobic era Warrant.
Gonna snatch that one for sure.
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Devin Townsend Solar Winds (2x Bass Pedal) just popped up.
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Any links yet for these songs? RBNStuff is not the same as it used to be.
It's only oversaturation if you have to switch discs.
Where's.. Tesla, Zeppelin, Gallagher, Floyd?
#1 Free Spirit fan!
XBL- ECOJIG DOT COM 1580 tx
Just listened to "The Elevator" by I Am Empire. Cool track. Will definitely add that to my "to buy" list. So far, that makes 4 songs in tomorrow's update that I'll be buying: The Elevator, Examination, Until the Night (RB3 version), and If You Can't Hang (which I've actually already purchased )
Add those to the list of "songs to buy" that I made last week, and it becomes apparent that I need more MSP. X_X
Happily discovering new music through the RBN since March 2010.
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All three lodges were rented for the wedding party and guests and not one person could find a complaint. The Valley Ranch was the location for the wedding and the views were the perfect backdrop. Ty, Anna, Jimmy, Heidi and the entire staff made sure everyone was taken care of and had a good time. This was my third trip... More
- Official Description (provided by the hotel):
- Royal Gorge Rafting, Zip Line Tours, Vacation Rentals & the White Water Bar & Grill ~ One Location, 100% Fun! ... more less

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Brain Pharmacology Database
Pathological Mechanisms
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Pathological mechanism List
Abeta (1-42) increases dopamine release in the prefrontal cortex
In the presence of tetrodotoxin, Abeta(1-42) at 100 nM evoked the release of dopamine to approximately 170% of basal levels in the pre-frontal cortex. The Abeta(1-42)-evoked dopamine release was sensitive to antagonists of alpha7 nicotinic receptors.
Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.
Spencer, J. P., Weil, A., Hill, K., Hussain, I., Richardson, J. C., Cusdin, F. S., et al. (2006). Transgenic mice over-expressing human beta-amyloid have functional nicotinic alpha 7 receptors. Neuroscience, 137(3), 795-805. Amyloid beta peptide(1-42) antagonized human alpha7 responses in a partially reversible fashion; no agonist effects were detected. A similar inhibition of mouse alpha 7 was also observed. Hippocampal GABAergic interneurones in slices from beta-amyloid over-expressing mice still possess alpha 7 receptor-mediated currents.
Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation
Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation in hAPP transgenic mice, that have cognitive deficits similar to AD. This seizure-like activity may lead to inhibitory mechanisms that produce cognitive deficits. Alzheimer's and Dementia Supplement, 2008 (ICAD meeting). Palop JJ, Thwin, Ho, Yu and Mucke
Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice
The study investigated the effects of elevated soluble Abeta on neuronal morphology in mutant human amyloid precursor protein (hAPP) transgenic mice somatosensory pyramidal cells. Basal arbors were unaffected, but apical arbors were shortened in total length and less branched. The diameter of proximal dendritic segments was increased whereas that of distal segments was reduced. There was a significant reduction in spine densities along the whole course of dendrites.
Abeta decreases dedritic spine number and alters dendritic spine morpholology
A review of loss or alteration of dendritic spines induced by the amyloid beta (Abeta) peptide in the context of AD. Dendritic spine loss and synaptic alterations in Alzheimer's disease.Knobloch M, Mansuy IM. Mol Neurobiol. 2008 Feb;37(1):73-82.
Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.Shrestha BR, Vitolo OV, Joshi P, Lordkipanidze T, Shelanski M, Dunaevsky A. Mol Cell Neurosci. 2006 Nov;33(3):274-82. Exposure of hippocampal neurons to sub-lethal levels of Abeta decreased spine density, increased spine length and subdued spine motility. The effect of Abeta on spine density was reversible. Moreover, Abeta's effect on dendritic spine density was blocked by rolipram, a phosphodiesterase type IV inhibitor.
Abeta decreases dendritic spine number, causes dysmorphic spine shapes
Calabrese, B., Shaked, G. M., Tabarean, I. V., Braga, J., Koo, E. H., & Halpain, S. (2007). Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Molecular and Cellular Neurosciences, 35(2), 183-193. Within 1-2 h picomolar concentrations of cell-derived, soluble Abeta cause Clusters of presynaptic vesicle markers to decrease in size and number at glutamatergic but not GABAergic terminals. Dendritic spines also decreased in number and became dysmorphic, as spine heads collapsed and/or extended long protrusions. Simultaneous time-lapse imaging of axon-dendrite pairs revealed that shrinking spines sometimes became disconnected from their presynaptic varicosity. Concomitantly, miniature synaptic potentials decreased in amplitude and frequency. Spine changes were prevented by blockers of nAChRs and NMDARs. Washout of Abeta within the first day reversed these spine changes.
Abeta increase in A-type K+ current is caused by modulation of Kv4 subunit expression
Amyloid beta peptide as a physiological modulator of neuronal 'A'-type K+ current.Plant LD, Webster NJ, Boyle JP, Ramsden M, Freir DB, Peers C, Pearson HA. Neurobiol Aging. 2006 Nov;27(11):1673-83.
Abeta inhibits late LTP in animal models of Alzheimers
Transgenic mice Alzhiemers models and hippocampal slice preparations from wild type rats support the Abeta Alzheimers hypothesis: that Abeta is a primary cause of Alzheimers (reviewed in Rowan et al 2003). Various transgenic mice show inhibition in LTP before amyloid plaques are deposited (Larson et al. 1999, Giacchino et al. 2000, Hsia et al. 1999, Chapman et al. 1999, Fitzjohn et al.2000, Moechars et al. 1999,Dewachter et al. 2002). Normal rat electrophysiology in hippocampal slices show that soluble 500 nM Abeta inhibits LTP induction (Lambert et al. 1998, Wang et al. 2002). These findings support the hypothesis that soluble Abeta disrupts synaptic plasticity in the hippocampus in early Alzheimers before Abeta plaques form.
Abeta inhibits LTP both in soluble and fibrillar conformational states
Abeta1-40 peptide in soluble and fibrillar forms (beta pleated sheets) that are morphologically distinct can both attenuate hippocampal long-term potentiation (LTP) in the CA1 in vivo. The fibrillar form may also influence transmitter release.Schmid, A. W., Freir, D. B., & Herron, C. E. (2008). Inhibition of LTP in vivo by beta-amyloid peptide in different conformational states. Brain Res, 1197, 135-142.
Abeta inhibits LTP through TNFalpha
Ligands that neutralize TNFalpha or genetic knockout of TNF-R1s (type-1 TNFalpha receptors) prevented Abeta-triggered inhibition of LTP in hippocampal slices. Similarly, antibodies to alphav-containing integrins abrogated LTP block by Abeta.Mild cognitive impairment in early AD (Alzheimer's disease) may be due to synaptic dysfunction long before widespread synaptic loss and neurodegeneration occurs. Rowan, M. J., Klyubin, I., Wang, Q., Hu, N. W., & Anwyl, R. (2007). Synaptic memory mechanisms: Alzheimer's disease amyloid beta-peptide-induced dysfunction. Biochemical Society Transactions, 35(Pt 5), 1219-1223.
Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals
Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals, causing failure of nicotine-dependent enhancement of synaptic efficacy at Schaffer-collateral CA1 synapses of AD11 anti-nerve growth factor transgenic mice. This takes place possibly through calcium signalling via presynaptic alpha7 nicotine acetylcholine receptors. Sola E, Capsoni S, Rosato-Siri M, Cattaneo A, Cherubini E. Eur J Neurosci. 2006 Sep;24(5):1252-64
Abeta modulates A current (HEK293 cells)
"Control of neuronal spiking patterns resides, in part, in the type and degree of expression of voltage-gated K(+) channel subunits. Abeta is a modulator of Kv4 subunit expression in neurones at both the functional and the molecular level. Thus Abeta is not only involved in Alzheimer pathology, but is also an important physiological regulator of ion channel expression and hence neuronal excitability." (Plant LD et al. 2005)
Abeta peptides block LTP in rat CA1 in vivo
"The effect of intracerebroventricular (icv) injections of beta-amyloid peptide fragments Abeta[15-25], Abeta[25-35], and Abeta[35-25] were examined on synaptic transmission and long-term potentiation (LTP) in the hippocampal CA1 region in vivo. ... LTP was, however, markedly reduced by Abeta[25-35; 10 nmol] (129 +/- 9%, n = 6, P < 0.001) and blocked by Abeta[25-35; 100 nmol] (99 +/- 6%, n = 6, P < 0.001). ... The Abeta-peptides tested were also shown to have no significant effect on paired pulse facilitation (interstimulus interval of 50 ms), suggesting that neither presynaptic transmitter release or activity of interneurons in vivo are affected. The effects of Abeta on LTP are therefore likely to be mediated via a postsynaptic mechanism. This in vivo model of LTP is extremely sensitive to Abeta-peptides that can impair LTP in a time- ([25-35]) and concentration-dependent manner ([25-35] and [35-25]). These effects of Abeta-peptides may then contribute to the cognitive deficits associated with Alzheimer's disease." (Freir DB et al. 2001)
Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors
ADDL binding instigates synapse loss, oxidative damage, and AD-type tau hyperphosphorylation.ADDLs act as pathogenic gain-of-function ligands that target particular synapses, binding to synaptic spines at or near NMDA receptors. Subsequent ADDL-induced abnormalities in spine morphology and synaptic receptor composition. Viola, K. L., Velasco, P. T., & Klein, W. L. (2008). Why alzheimer's is a disease of memory: The attack on synapses by A beta oligomers (addls). The Journal of Nutrition, Health & Aging, 12(1), 51S-57S.
Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers
Abeta42/Abeta40 ratio correlates with impaired LTP and with dendritic spine density and behavioral competence in the Tg2576 mouse model of AD. This happens before there is any significant increase in beta amyloid levels. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease.Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, Martone R, Morrison JH, Pangalos MN, Reinhart PH, Bloom FE. Proc Natl Acad Sci U S A. 2006 Mar 28, 103(13):5161-6.
Alpha4beta2 receptor blockade causes memory impairment
Pocivavsek, A., Icenogle, L., & Levin, E. D. (2006). Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats. Psychopharmacology, 188(4), 597-604. The state of nicotinic receptor activation in the ventral hippocampus significantly affected the impact of clozapine on working memory with blockade of alpha7 nicotinic receptors potentiating clozapine-induced memory impairment and blockade of alpha4beta2 receptors reversing the clozapine effect from impairing to improving memory.
Aluminum alters GABAA receptors
" ... aluminum can alter the function of GABAA receptors and may suggest that aluminum can contribute to cognitive impairment through disruption of inhibitory circuits." (Trombley PQ 1998)
AMPA receptor downscaling in AD
Experiments with double knockin mice suggest that AMPARs are important synaptic targets for AD and provide evidence that cognitive impairment may involve downscaling of postsynaptic AMPAR function (Chang EH et al. 2006)
Amyloid plaques increase elimination of dendritic spines
Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT.Am J Pathol. 2007 Oct;171(4):1304-11. In control animals, spine formation and elimination were equivalent over 1 hour of observation ( approximately 5% of observed spines), resulting in stable spine density. However, in aged Tg2576 mice spine elimination increased, specifically in the immediate vicinity of plaques. Spine formation was unchanged, resulting in spine loss.
Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density
Ji, Y., Gong, Y., Gan, W., Beach, T., Holtzman, D. M., & Wisniewski, T. (2003). Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and alzheimer's disease patients. Neuroscience, 122(2), 305-315. Human apoE3 and WT mice had a higher density of dendritic spines than human E4 and apoE KO mice in the 1 and 2 year age groups. In human brain, apoE4 dose correlated inversely with dendritic spine density of DG neurons cell in the hippocampus of both AD (P=0.0008) and aged normal controls (P=0.0015).
BACE1 required for LTP at mossy fiber-CA3 synapses
BACE1 knock-out mice display reduced presynaptic function at the mossy fiber projections in CA3. Mossy fiber long-term potentiation (LTP), which is normally expressed via an increase in presynaptic release, was eliminated in the knock-outs. The specific deficit in mossy fiber LTP was upstream of cAMP signaling and could be "rescued" by transiently elevating extracellular Ca2+ concentration. These results suggest that BACE1 may play a critical role in regulating presynaptic function, especially activity-dependent strengthening of presynaptic release, at mossy fiber synapses. BACE1 knock-outs display deficits in activity-dependent potentiation of synaptic transmission at mossy fiber to CA3 synapses in the hippocampus.Wang H, Song L, Laird F, Wong PC, Lee HK. J Neurosci. 2008 Aug 27;28(35):8677-81.
beta Amyloid increases calcium currents (2)
"...beta-Amyloid(1-40) is related to an increase of non-L-type Ca channels ..." (Rovira C, et al. 2002).
Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
Welsby, P. J., Rowan, M. J., & Anwyl, R. (2007). Beta-Amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP. Neuropharmacology, 53(1), 188-195. Postulate that nicotine-enhanced LTP has certain different mechanisms to that of control LTP which results in a resistance to inhibition by Abeta.
beta-Amyloid impairs LTP/LTD
Impairment of LTP by beta-Amyloid is independent of NMDA receptors or voltage dependent Ca currents (Nomura I et al. 2005)
beta-amyloid reduces IA
Application of beta-amyloid to outside-out patches reduces the A-current; leading to increased dendritic calcium influx and loss of calcium homeostasis, potentially causing synaptic failure and initiating neuronal degenerative proceses(Chen C 2005).
beta-Amyloid-induced depression of LTP attenuated by Verapamil
Experimental findings suggest that verapamil, an L-type (VDCC) calcium channel blocker may be useful in the cognitive deficits associated with AD (Freir DB et al. 2003)
Chronic nicotine decreases NGF and improves memory performance
Chronic nicotine improves working and reference memory performance and reduces hippocampal NGF in aged female rats.French KL, Granholm AC, Moore AB, Nelson ME, Bimonte-Nelson HA. Behav Brain Res. 2006 May 15;169(2):256-62 There is a nicotine-induced reduction in nerve growth factor (NGF) protein levels in the hippocampus of the aged rat. Nicotine improved the ability to handle an increasing working memory load as well as enhanced performance on the reference memory component of the water radial arm maze task.
DHA increases dendritic spines and synapses; enhanced by uridine and choline
DHA also affects synaptic transmission in mammalian brain. Brain cells of gerbils or rats receiving this fatty acid manifest increased levels of phosphatides and of specific presynaptic or postsynaptic proteins. They also exhibit increased numbers of dendritic spines on postsynaptic neurons. These actions are markedly enhanced in animals that have also received the other two circulating precursors for phosphatidylcholine, uridine (which gives rise to brain uridine diphosphate and cytidine triphosphate) and choline (which gives rise to phosphocholine). Cansev, M., Wurtman, R. J., Sakamoto, T., & Ulus, I. H. (2008). Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 4(1 Suppl 1), S153-S168.
Donepezil modulates potassium channels
This work was the first to show different effects of donepezil on two different types of potassium channels (I K(DR) and I K(A)) of molluscan neurons. At a low concentration (5 uM), the drug suppressed I K(DR) but augmented I K(A); at higher concentrations (10-100 uM), it reduced both current types. The ability of donepezil to reduce I K(DR) at low concentrations suggests the drug ability to prevent neurodegeneration in Alzheimer's disease. (Solntseva et al., 2005)
Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
Counts, S. E., Nadeem, M., Lad, S. P., Wuu, J., & Mufson, E. J. (2006). Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment. Journal of Neuropathology and Experimental Neurology, 65(6), 592-601. Levels of DRB, a dendritic spine plasticity marker, were reduced approximately 40% to 60% in all cortical regions in AD compared with normals.In contrast, DRB levels in the superior frontal cortex increased approximately 30% in AD subjects.
Galantamine increases dopamine release in the hippocampus
The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems.Wang D, Noda Y, Zhou Y, Mouri A, Mizoguchi H, Nitta A, Chen W, Nabeshima T. Neuropsychopharmacology. 2007 Jun;32(6):1261-71. Galantamine augments dopaminergic neurotransmission within the hippocampus through the allosteric potentiation of nAChRs. The improving-effects of galantamine on the Abeta(25-35)-induced cognitive impairment may be mediated through the activation of, at least in part, dopaminergic systems
Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.
Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.Santos-Torres J, Fuente A, Criado JM, Riolobos AS, Heredia M, Yajeya J. BetaA effect was blocked by calcicludine (50 nM), a selective antagonist of L-type calcium channels, and also by blocking muscarinic receptors with atropine (5 muM) or pirenzepine (1 microM), a more specific M1-receptor blocker.
Histidine associating compounds block Abeta Channel activity and cytotoxicity
The opening of the Alzheimer's Abeta channel permits the flux of calcium into the cell, thus critically disturbing intracellular ion homeostasis. Peptide segments which include the characteristic histidine diad, His13 and His14, efficiently block the Abeta channel activity blocking Abeta cytotoxicity. Compounds that are known to have histidine association capacity, such as Ni(2+), imidazole, histidine and a series of histidine-related compounds were effective at blocking both Abeta channels and preventing Abeta cytotoxicity. The efficiency of protection of histidine-related compounds was correlated with the number of imidazole side chains in the blocker compounds. Efficiency of histidine-associating compounds for blocking the Alzheimer's A{beta} channel activity and cytotoxicity.Arispe NJ, Diaz JC, Flora M. Biophys J. 2008 Aug 22.
Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice
Three-dimensional analysis of 21 507 dendritic spines in the dentate gyrus, a region crucial for learning and memory, revealed a substantial decrease in the frequency of large spines in plaque-free regions of APP/PS1 mice. Plaque-related dendrites also show striking alterations in spine density and morphology. However, plaques occupy only 3.9% of the molecular layer volume. Because large spines are considered to be the physical traces of long-term memory, widespread decrease in the frequency of large spines likely contributes to the cognitive impairments observed in this AD model. Knafo, S., Alonso-Nanclares, L., Gonzalez-Soriano, J., Merino-Serrais, P., Fernaud-Espinosa, I., Ferrer, I., et al. (2008). Widespread changes in dendritic spines in a model of alzheimer's disease. Cerebral Cortex
LTP requires BDNF and is associated with cytoskeleton-associated protein
Bramham, C. R. (2007). Control of synaptic consolidation in the dentate gyrus: Mechanisms, functions, and therapeutic implications. Progress in Brain Research, 163, 453-471. Dysregulation of BDNF synthesis and Arc function, specifically within the dentate gyrus, is linked to behavioral symptoms and cognitive deficits in animal models of depression and Alzheimer's disease.
Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist
A beta(3)-AR agonist (CL316243), but not a beta(2)-AR agonist, rescued Abeta-induced memory loss in chicks given an intra-cranial injection of Abeta42. Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist.Gibbs ME, Maksel D, Gibbs Z, Hou X, Summers RJ, Small DH. Neurobiol Aging. 2008 Jul 14
Model block of I_A
A model shows that block of I_A is sufficient to cause membrane depolarization, calcium influx, and increased excitability (Good TA, Murphy RM 1996).
Muscarinic receptor agonists and nicotine may prevent neurodegeneration in AD
Abeta binds to the extracellular cysteine-rich domain of the Frizzled receptor (Fz) inhibiting Wnt/beta-catenin signaling. Cross-talk with other signaling cascades that regulate Wnt/beta-catenin signaling, including the activation of M1 muscarinic receptor and PKC, the use of Ibuprofen-ChE bi-functional compounds, PPAR alpha, gamma agonists, nicotine and some antioxidants, results in neuroprotection against Abeta. Inestrosa, N. C., & Toledo, E. M. (2008). The role of wnt signaling in neuronal dysfunction in alzheimer's disease. Molecular Neurodegeneration, 3(1), 9.
Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla
Only weak correlations between psychometric indices and plaques and tangles, but the density of neocortical synapses reveals very powerful correlations withpsychological assays in AD/normal subjects. Midfrontal and inferior parietal synapse density, plus inferior parietal plaque has a correlation coefficient of 0.96 with Mattis's Dementia Rating Scale. Plaque density contributed only 26% of that strength.
Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline
Akram, A., Christoffel, D., Rocher, A. B., Bouras, C., Kövari, E., Perl, D. P., et al. (2007). Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: Relationship with the progression of alzheimer's disease. Neurobiol Aging, , Spinophilin is a postsynaptic marker mainly located to the heads of dendritic spines. Data suggest that neocortical dendritic spine loss is an independent parameter to consider in AD clinicopathologic correlations.
NGF restores dendritic spine density in Layer V pyramidal neurons
Mervis, R. F., Pope, D., Lewis, R., Dvorak, R. M., & Williams, L. R. (1991). Exogenous nerve growth factor reverses age-related structural changes in neocortical neurons in the aging rat. A quantitative golgi study. Annals of the New York Academy of Sciences, 640, 95-101. NGF treatment restored dendritic spine densities to those seen in young controls on terminal tip segments ("plastic" regions). Internal branch segments ("nonplastic" regions) showed no response to NGF.
Nicotine desensitize alpha7 nACh receptors and facilitates LTP
Yamazaki, Y., Jia, Y., Hamaue, N., & Sumikawa, K. (2005). Nicotine-Induced switch in the nicotinic cholinergic mechanisms of facilitation of long-term potentiation induction. Eur J Neurosci, 22(4), 845-860. Suggest that nicotine promotes the induction of LTP by diminishing inhibitory influences on NMDA responses while suppressing the ACh-mediated mechanisms. These ACh-independent mechanisms probably contribute to the nicotine-induced cognitive enhancement observed in the presence of cholinergic deficits, such as those in Alzheimer's disease patients.
Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo
Hippocampal long-term potentiation (LTP) is a form of synaptic plasticity used as a cellular model of memory. Beta amyloid (A beta) is involved in Alzheimer's disease (AD), a neurode-generative disorder leading to cognitive deficits. Nicotine is also claimed to act as a cognitive enhancer. A beta is known to bind with high affinity to the alpha 7-nicotinic acetylcholine receptor (nAChR). ... (Experiments) demonstrate that nicotine enhances the deficit in LTP produced by A beta 1-40. This then suggests that nicotine may exacerbate the depressive actions of A beta on synaptic plasticity in AD. (Freir DB, Herron CE 2003)
Okadaic acid mediates tau phosphorylation via L channel activation
Prior studies indicate that one of the kinases that phosphorylates tau (mitogen-activated protein kinase, or MAP kinase) does so at least in part indirectly within intact neuronal cells by phosphorylating and activating the L-voltage-sensitive calcium channel. Resultant calcium influx then fosters tau phosphorylation via one or more calcium-activated kinases. okadaic acid (OA) similarly may increase tau phosphorylation via sustained activation of the L-voltage-sensitive calcium channel. OA increased phospho-tau as indicated by increased immunoreactivity towards an antibody (PHF-1) directed against paired helical filaments from AD brain. This increase was blocked by co-treatment with the channel antagonist nimodipine. ... Okadaic acid (OA) treatment increased channel phosphorylation. The increases in calcium influx, PHF-1 immunoreactivity and channel phosphorylation were all attenuated by co-treatment with PD98059, which inhibits MAP kinase activity, suggesting that OA mediates these effects at least in part via sustained activation of MAP kinase. (Ekinci FJ et al. 2003)
p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
"p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro. ... Results show that sAbeta(1-42) at relatively low levels (1-5 microM) dose-dependently increases tau phosphorylation at AD-specific phosphoepitopes in differentiated N2a/p35 cells compared with controls, an effect that is blocked by antisense oligonucleotides against p35. sAbeta(1-42)-induced tau phosphorylation is concomitant with an increase in both p25 to p35 ratio and Cdk5 activity (but not protein levels). Additionally, blockade of L-type calcium channels or inhibition of calpain completely abolishes this effect." (Town et al. 2002)
Picomolar concentrations of abeta monomers disrupt LTP
Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior.Selkoe DJ. Behav Brain Res. 2008
Presenilin-1 deficient neurons have increased activity of L channels
Presenilins 1 and 2 (PS1 and PS2, respectively) play a critical role in mediating gamma-secretase cleavage of the amyloid precursor protein (APP). Numerous mutations in the presenilins are known to cause early-onset familial Alzheimer's disease (FAD). In addition, it is well established that PS1 deficiency leads to altered intracellular Ca(2+) homeostasis involving endoplasmic reticulum Ca(2+) stores. However, there has been little evidence suggesting Ca(2+) signals from extracellular sources are influenced by PS1. Here we report that the Ca(2+) currents carried by voltage-dependent Ca(2+) channels are increased in PS1-deficient cortical neurons. This increase is mediated by a significant increase in the contributions of L- and P-type Ca(2+) channels to the total voltage-mediated Ca(2+) conductance in PS1 (-/-) neurons. (Cook et al. 2005)
Protofibrillar intermediates of ABeta change firing pattern of neurons.
Protofibrils, but not (Light Molecular Weight) Abeta, produced a rapid increase in EPSPs, action potentials, and membrane depolarizations (and neurotoxicity) in cultured neurons from rat embryo brain. (Hartley et al. 1999)
Regulation of back-propagating action potentials in hippocampal neurons.
Johnston, D., Hoffman, D. A., Colbert, C. M., & Magee, J. C. (1999). Regulation of back-propagating action potentials in hippocampal neurons. Current Opinion in Neurobiology, 9(3), 288-292. Protein kinase C modulates the slow recovery from inactivation of Na+ channels in apical dendrites of hippocampal CA1 pyramidal neurons. Dendritic, A-type K+ channels have been found to be modulated by protein kinases A and C and by mitogen-activated protein kinase.
Sub-nanomolar concentrations of oligomeric beta amyloid inhibits late LTP in rats and mice
Synaptic plasticity in animal models of early Alzheimer's disease.Rowan MJ, Klyubin I, Cullen WK, Anwyl R. Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):821-8.
Synaptic integration is disrupted in an AD mouse model
The evoked synaptic response of neurons to transcallosal stimuli is severely impaired in cortex containing substantial plaque accumulation, with an average 2.5-fold greater rate of response failure and twofold reduction in response precision compared with age-matched nontransgenic controls. ... results show that plaques disrupt the synchrony of convergent inputs, reducing the ability of neurons to successfully integrate and propagate information. (Stern et al. 2004)
The channel hypothesis of Alzheimers disease
The channel hypothesis of Alzheimer's disease (AD) proposes that the beta-amyloid (Abeta) peptides which accumulate in plaques in the brain actually damage and/or kill neurons by forming ion channels. Evidence from a number of laboratories has demonstrated that Abeta peptides can form ion channels in lipid bilayers, liposomes, neurons, oocyctes, and endothelial cells. These channels possess distinct physiologic characteristics that would be consistent with their toxic properties. Abeta channels are heterogeneous in size, selectivity, blockade, and gating. They are generally large, voltage-independent, and relatively poorly selective amongst physiologic ions, admitting calcium ion (Ca(2+)), Na(+), K(+), Cs(+), Li(+), and possibly Cl(-). They are reversibly blocked by zinc ion (Zn(2+)), and tromethamine (tris), and irreversibly by aluminum ion (Al(3+)). Congo red inhibits channel formation, but does not block inserted channels. Although much evidence implicates Abeta peptides in the neurotoxicity of AD, no other toxic mechanism has been demonstrated to be the underlying etiology of AD. Channel formation by several other amyloid peptides lends credence to the notion that this is a critical mechanism of cytotoxicity.
This database was supported by the Human Brain Project (NIDCD, NIMH, NIA, NICD, NINDS) and MURI (Multidisciplinary University Research Initiative). It is now supported by RO1 DC 009977 from the National Institute for Deafness and other Communication Disorders.
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Animals Facing Left Worksheet
Kids will enjoy practicing recognizing left in this printable worksheet. Kids are asked to look at all the animals on the page and circle only the ones that are facing left. Click the link or image below to print your copy of this facing left worksheet.
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Sunrise Fitness Snowshoe (Ages 13+) | |
Perfect for early rising fitness fanatics! See the sun rise over the beautiful Monashee mountains and get in shape at the same time! Routes will depend on the ability level of the group - beginner groups will head up green runs, intermediates up blues and experts up blacks - all before the skiers and boarders hit the slopes. Prepare to see a spectacular side of Big White most people never get to experience! |
Runs: 6:30am – 7:30am* | |
Drop in: $18 + tax with rentals, $12 + tax without rentals | |
*Must be booked at least a day in advance, rentals need to be picked up the day before* | |
Sunset Fitness Snowshoe (Ages 13+) | |
If early mornings aren't for you then why not head out on a sunset tour? Watch the sun go down over the horizon from the top of the runs and really earn that apres! Like the Sunrise option, routes depend on the ability level of the group. |
Runs: 4:30pm – 5:30pm* | |
Price: $18 + tax with rentals, $12 + tax without rentals | |
*Must be booked by 3:30pm* | |
Adventure Tours |
Interpretive Tour | |
Become one with nature on our interpretive tour and learn more about the local environment. Our fully-trained guides will share their knowledge of our beautiful British Columbian back-country, flora and fauna and really enhance your Big White experience. |
Runs: 10:00am – 12:00pm | |
Adult: $36 + tax with rentals, $30 + tax without rentals |
Child (under 12): $30 + tax with rentals, $24 + tax without rentals | |
Family Adventure Tour | |
A great way to enjoy the great outdoors with the whole family, regardless of ability. Head out on our trails with our fully-trained guides who will tailor your route to suit the needs of the everyone in your group. All ages are welcome on this fun tour. |
Runs: 1:30pm – 3:30pm | |
Adult: $36 + tax with rentals, $30 + tax without rentals | |
Child (under 12): $30 + tax with rentals, $24 + tax without rentals | |
Moonlight Tour | |
See the beauty of Big White by moonlight! From the village lights below to the constellations above, round off your day on the slopes with a perfect sight not to be missed. Headlamps will be provided and you will need to dress very warm. Please inquire at the Activities Desk before 3:30pm for availability and to book your tour. |
Runs: 8:00pm till late (depends on weather and light conditions – during full moon only) | |
Adult: $36 + tax with rentals, $30 + tax without rentals |
Child (under 12): $30 + tax with rentals, $24 + tax without rentals |
Direct Line: 250.491.6111
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Hi. Need a window treatment. Love french cottage style. Would love a floral curetain or valance but my wall is already a floral. Here are pics of my living room and pics of inspiration. Any advice is appreciated | |||
Here are my inspiration. Is it too much | ||||
What about a check or simple floral like the inspiration picture has on the chairs for curtain panels since you have floral on your pillow and wall. A smaller buffalo check though, not as big as the ones on the inspiration picture chair. | ||||
I can't tell what colors are in your floral wall but the souleiado prints would work with florals. | ||||
Thanks for advice. My wallpaper is lookout mountain by waverly. Here's a pic. The pic is a little yellow. | ||||
At one time Waverly had a coordinating stripe to your floral print. A green and cream check or ticking stripe would look good with it. http://www.countrycurtains.com...rPicks&page=newpage1 To answer your original question, you could add another floral but it is not the easiest thing to do without it becoming "too much" as you said. Scale and balance of colour are the key to a successful combination. | ||||
I notice that your inspiration room actually uses two different curtain fabrics and treatments - end walls with valance have different curtain fabric than focal wall. All of this is just to emphasize that the success of the french country look is the layering of prints: different sizes of print element (to scale for its use), some classic combos and complimentary colors are the baseline for that kind of bold layering. I'm going to put up a few that might work for you to explore (sale happening now, which is nice!) If you did go green and cream on your window treatments (a more flexible long term move in a living room where your floral reds tend to the berry) you might like these combos for window treatments - drapery would be amazing in this print with the large scale repeat: http://www.calicocorners.com/p...s+fabrics+-+grass.do and you could layer in /add to the drapery a vertical pull border / add a valance in the coordinating check with the 9" repeat: http://www.calicocorners.com/p...alo+check+limeade.do or take the smaller repeat check for a new couch pillow to echo the green below / layer more. If it is the reds you love and are drawn toward, and the berry tones match, then you could head into toile - another classic http://www.calicocorners.com/p...house+party+berry.do and of course investigate a coordinating check http://www.calicocorners.com/p.../checkmate+claret.do For a small trim to make things feel rich and layered (like welting on the first fabric at the vertical border divide?) something like this that picks up all the tones of the paper would make a statement, or if you wanted to add a small accent pillow to the couch to echo checks. http://www.calicocorners.com/p...ed/malaga+orchard.do this would be a bright spot of color - also great for a bench or seat cushion in an adjacent dining / kitchen space as it is a little more casual If you go red because that is your love, you can always add a different toned green to the couch pillows with cream - like this http://www.calicocorners.com/p...+handprint+parrot.do beautiful cream backed fabric. One of the challenges is determining how creamy or how white you want to stay with what you add and the photos show white walls, a very white couch and pillows, and the tones in the paper suggest pale yellow. The first swatches rely on white - in real life, if you have cream, don't add white based fabrics. Stick with the creamy base like in the berry toile and this cream and gream medallion - So - tried to use these more as examples of the principles I think you want to consider as you choose fabrics. You are best served by getting swatches and then 1/2 yards and laying them over the back of your couch to "test drive" the color tones in your room with your space, etc. It is great to see someone going for the look they love when it is bold. Hope this helps!This message has been edited. Last edited by: LibraDesignEye, | ||||
Thanks so much for your great advice. I tend to be drawn toward the reds and white floral like waverly ballad bouquet https://www.google.com/search?...34;d|Bjtj5ZGWl5Ji2M: or Norfolk rose. my wallpaper has an almost khaki background. I've attached a better pic. I'm thinking I might have to get rid of the wallpaper. Plus the cabbage roses are really more of a mauve/ burgundy than a red. I like your advice about getting a couple yards of fabric to see if I like it. Val | ||||
I think the window is screaming a printed flower valance and cordinating color panel.Even a designed panel like the check,plaid or paisley.The walls and sofa is solid,so having more prints around the area is what you want and needs. LOVE your inspiration pic.Lovely room. | ||||
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text: Home Politics When Unemployment Runs Out: Meet the 99ers Millions of jobless Americans are out in the cold after exhausting their unemployment insurance. Now what? By: Cynthia Gordy Posted: April 13 2011 10:08 AM 0 On Unemployed Friends 2.0, a message board for people who have been out of work long enough to exhaust all emergency unemployment insurance -- "99ers," as some have taken to calling themselves -- users let off steam in the Venting Forum. I am sooo tired of calling temp agencies week after week with no callbacks or results ... I'm burned out from over 2 years of this routine. --503Depressed This feels like a permanent state. Even though I send out resumes, I don't really think anyone is going to call or that I will ever work again. --nfpexec Been unemployed over 2 years, sent out resume to hundreds of jobs, 4 interviews and nothing. Nothing, nothing, nothing. --js123 Please don't give up, be good to yourself today, and try to stay positive. We are all in this together. You are not alone. --DesperateInRI Given the focus on spending cuts in Washington, one might think that America's unemployment problem was under control. But our jobs quandary is far from over, surpassing even the Great Depression in one respect: The gap between the number of people out of work (13.9 million) and the number of job openings (2.8 million) has never been so wide. Congress responded to these historically grim conditions in 2009 by extending unemployment benefits to an unprecedented 99 weeks. For many Americans, however, time is up, with no job in sight. "We're in extraordinary times that break all the rules with respect to recovery," Gregg Rosen, co-founder of the American 99ers Union, told The Root. He explained that "99er" is a generalized term representing individuals who have exhausted all benefits up to 99 weeks, since the length of emergency unemployment insurance varied depending on the state. While the March jobs report (pdf) showed that nearly 1.9 million workers have been unemployed for the maximum 99 weeks (an increase of 127,000 from February), more than 6 million have actually reached the limit of their insurance. With five unemployed workers for every job opening, their ranks are only growing. Legislation to extend unemployment benefits for 99ers, introduced by two Congressional Black Caucus members, is being discussed, but the heavily opposed idea has made little headway. Meanwhile, as they drop off of Washington's radar, and as the Obama administration lauds an unemployment rate that edged down to 8.8 percent last month, millions of Americans in financial free fall can't help feeling effectively abandoned. "One reason that [unemployment] number is going down is because once you become a 99er, you're no longer counted on the record as unemployed," said Rosen. "With respect to how the government collates the numbers, these people sort of just disappear." Page 1 of 4 NEXT PAGE > Powered by Livefyre


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2014 Chevrolet Impala
The big sedan segment has no clear leader. The Ford Taurus, Dodge Charger, Chrysler 300 and Nissan Maxima are all fine cars but all have their flaws. Toyota's new Avalon is a modern marvel in terms of comfortable cruising. This radically rethought Impala, after seven years of stagnation, is hugely important to GM, and we want to see where the company stands after swinging and missing with the latest Malibu.
December 10, 2012


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Corey Lewis
This item is currently sold out.
Ceasar Hallelujah & friends return in this EPIC sequel to 2005's Sharknife: Stage First! Sharknife has fought 100 battles and its time to level up! But at what cost? Will he face defeat at the hands of his nemesis, Ombra the Orcasword? Who is Daring Hallelujah? And who are the SCARS of REXIMUS? Find out in SHARKNIFE: DOUBLE Z! Complete with new villains, new heroes, and new transformations!


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We saw a lot of these images from Saddam's palaces that U.S. troops took over following the fall of Baghdad. But this is my first chance to see soldiers getting a fun pool break in Afghanistan.
Ed Jones / AFP - Getty Images
U.S. and Canadian soldiers lounge and swim at a pool at Camp Nathan Smith in Kandahar city on Wednesday, June 9. NATO, US and Afghan soldiers are preparing their biggest offensive yet against the Taliban in Kandahar province, with total foreign troop numbers set to peak at 150,000 by August..


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First married Catholic priest ordained in Buffalo, NY under papal celibacy exception rule
Former Episcopalian priest who is married with children to be ordained this week in NY
Published Thursday, January 24, 2013, 7:29 AM
Updated Saturday, June 29, 2013, 2:42 AM
39 comments
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merefalow | Jan 28, 2013, 09:55 AM EST
like ive always said,its a chameleon,it will adapt,sickening.
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Meanolgrouch | Jan 26, 2013, 03:44 PM EST
Eiriamach, while I can't buy into SD's comments, I must commend your own. However, do let me offer a slightly different perspective. As an ardent though dissident Catholic myself, I hope what's happening will by the law of unintended consequences result in FORCING more inclusive acceptance into the Church. Sometimes all it takes is a few cracks in the door to let in some fresh air and sunshine; I stand ready with my own little hatchet to help in that way. The more declining membership and clergy force the admission of already-married clergy, the sooner those who entered service under the celibacy rules will demand equal rights. The Church may have grown creaky with age, but it's made up of people, and the vast majority demand freedom. (Not license; that's another story.) God bless 'em, the Jesuits might even lead the charge. Wouldn't that be a beautiful sight?
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eiriamach | Jan 26, 2013, 09:09 AM EST
The Anglican priests fleeing change in their churches by entering the ordinariates set up by the Vatican don't seem to mind that they are buying into a profound change -- not for themselves but for the next generation of their priests. Those who enter the ordinariates as married priests may stay married, but all new priest candidates in the ordinariates must be celibate. What kind of "unchanging tradition" are they safeguarding for their brethren? And what other changes will the Vatican impose on the ordinariates?
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eiriamach | Jan 26, 2013, 09:00 AM EST
@Jacers, like other converts from Anglican churches, Fr Cornelius does not deal well with change or with Christianity as an inclusive community. He left his Episcopalian ministry because ECUSA had ordained gay males and women. He explained to a Boston newspaper, "I'm a traditionalist in a lot of ways." He has never said publicly that he found the one true faith in the Catholic Church. In fact, he had also affiliated with Baptists, Methodists, Presbyterians, Baha'i, and Hare Krishna before he settled into his current stodginess. For people like Fr Cornelius, religion is a set of unchanging cultic practices that provide a psychological barrier against the civic virtue of justice and the theological virtue of inclusive love. Jesus prayed for a unified church, not churches divided by politics, not tradition vs reform, but 'ecclesia semper reformanda.'
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Meanolgrouch | Jan 25, 2013, 09:50 PM EST
The NY Daily News is a rag sheet. It would be the height of absurdity to believe them (or Faux TV) about anything. Ridiculous as the Church can be sometimes, they're not so foolish.
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SingleDonald | Jan 25, 2013, 08:25 PM EST
The N.Y. Daily News printed a shocking article today. It said that Father John Cornelius would be prohibited from sleeping with his wife, once he is ordained! Can anyone verify if this is true? If so, it is the height of absurdity, which the new priest should openly defy. "Yes, I slept with my wife: what are you going to do about it, Bishop, Cardinal, or even Pope Benedict XVI"? If he is then kicked out of the priesthood, the Church will be ridiculed mercilessly!
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kscorletta | Jan 25, 2013, 12:36 PM EST
I guess if the article had been
more grammatically correct, it
would have been ok, but he may
be the first Buffalo Episcopal
Minister to be made a priest,
but a newfound relative Rev.
Scott Caton of Rochester, NY,
predates him. We're both
descended from John Gilligan.
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Meanolgrouch | Jan 25, 2013, 12:01 PM EST
As an ardent if dissident Catholic, I wish to remind everyone that many of the earliest clergy WERE married, and the official prohibition against married clergy didn't come along for quite a few centuries. Don't ask me exactly when, I've just had my meds; look it up for yourself. It's there. Besides, many of the early church fathers including more than one on the Seat of St. Peter went forth and were fruitful w/o benefit of marriage; so where does the moral authority originate to burden any servant of God with required celibacy? I rather prefer it myself at this stage of life, but it is a personal choice. Besides, with all the pedophile scandal - which cannot be laid at the door of celibacy, btw - the Pope and magisterium pretty well lost their iron grip on the faithful. I'd rather stay with the church and help cleanse it, but I'll not live my life under the rule of those with no room to preach to the rest of us. Actually, I stay as much for the sake of honest and good priests past, present, and future, as for any other reason. I could switch to high-church Episcopal w/o batting an eye; they'll even let me keep my saints and devotion to Mary. Regardless, for many reasons it's crucial to the health of the Catholic church to bless priests who marry even AFTER ordination.
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klamorge | Jan 24, 2013, 10:58 PM EST
This is incorrect. Father Van K Thompson, and episcopal priest who taught at Providence College in
Rhode Island, Was ordained a catholic priest.He was married an had children,who went to catholic
school.There have been many ordinations of married men in the united states.
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jacersagain | Jan 24, 2013, 09:35 PM EST
Pardon me mistypo in - "Go tell everyone…" That appears to have been His choice and I, and nobody else as well have a say in that choice" It should read "not" ...
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jacersagain | Jan 24, 2013, 09:24 PM EST
(…more) On the third part of Scott's post, I agree – there is nothing except RCC Canon Law (which is changeable) to stop married men being priests, or being unmarried priests and being allowed to marry… and perhaps the day may yet come when Canon Law changes to allow them to go about Christ's mission if they are called to do so in those ways. I trust in the Holy Spirit of Wisdom's guidance on that for now and in the future.
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jacersagain | Jan 24, 2013, 09:14 PM EST
(…more) On the third part of Scott's post, I agree – there is nothing except RCC Canon Law (which is changeable) to stop married men priests, or being priests and being allowed to marry… and perhaps the day may yet come when Canon Law changes to allow them to go about Christ's mission if they are called to do so in that way. I trust in the Holy Spirit of Wisdom's guidance on that for now and in the future.
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jacersagain | Jan 24, 2013, 09:07 PM EST
(…more) I encourage all to visit Mary Magdalene's cave (plan to linger at your leisure, after the time it takes you to get there, for a few hours when you get there, say 3-5 hrs all-in, including some thought-time, which is unbelievably unavoidable for non-believers, or prayer-time or refreshing tea or beer time; I did it in 3.5 hrs, excluding beer time. Be ready, though, for the walking climb up to the cave and back down again! – take the easy route built for the once-time kings and queens of Europe on their pilgrimage route to San Diego de Compestela. I took the easy route up to the cave and the gloriously enjoyable old real and (back in old times) only original hard route up and down, back down through the forest (tough walking shoes/boots only, none of them pretty fashion shoes on yr feet advised; lotsa steep stone-stepping involved in the forest route, great for sport adventurers like me). Alternatively, you can choose the hard way up (Steep leg muscle-sapping stepping, 1 hr) or the easy way down (a stroll down the gentle hill of kings and queens), both clearly marked and shown by signs for yr choice. Also visit the local church in the convent on the grassy plain below the Ste Baume Mountain, where you can see nuns daily constantly honouring Mary Magdalene. (… even more on Scott's post)
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jacersagain | Jan 24, 2013, 09:01 PM EST
(…more) (flippn' repeats!) I once visited the cave where Mary Magdalene lived out her last 30yrs of life as a hermit, in the mountains of Ste Baume in France (Google Earth it) and I saw her skull in the nearby town of Sainte Maxime, named after her close friend Maxime, the first 'bishop' of that area of Sth France, who buried her in a stone casket beneath the church he raggedly built as was normal in his day. (The traditional historical story told by the people who live in the area there has it that she died in Maxime's arms. The spot where she died is still marked to this day by an old, beautifully carved and engraved Roman column that was part of the old Roman towngate, which was preserved by all the Christians living in the area throughout the centuries since (despite development of other things around it, like its immediate fast-moving traffic road, feranbegawd's sake, no chance to stop and take a photo of it). It still stands to this day for all to see as you enter the now-big town of Ste Maxime. I saw the column (almost missed seeing it but be jaysus wasn't I lucky to see it as I drove by it into the town to visit St. Maxime's Church where St Mary Magdalene's skull can be seen by all, at no price charge. (Even more on Scott's post…)
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jacersagain | Jan 24, 2013, 06:41 PM EST
@ ScottMcGowan: Great truth in the first part of yr post but the second bit regarding women priests is unfortunately just a never-achievable aspiration for many of us lay Catholics – a true test of our humility before God's judgement against our own wishful human-equality thinking. As for Mary Magdalene, who was called the "Apostle of the Apostles" by St. Thomas Aquinas, you have to remember that "Apostle" means Messenger. St Mary Magdalene was the one who carried the message of Christ's Resurrection to the others… she was the Messenger (of the Resurrection) to the Appointed Messengers to the world, the ones that our Lord appointed to "Go tell everyone…" That appears to have been His choice and I, and nobody else as well have a say in that choice, not even the Vatican and other Catholic Churces Popes have either. In fact, she was the "Apostle TO the Apostles". (More…)
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A Magdalene Laundry US adoptee who holds no hatred for Irish nunsImagine the wee bairn whose father was a priest with bad blood and all, no hope of finding their roots.
Families as well as Catholic Church and government to blame for illegal adoptionsAn american friend of mine was adopted from Castlepollard in l955 at 2 years old. Hes tried several routes to get paperwork (came and visited for one
Gay wedding cakes latest target of anti-gay bigotsThe proper word for "SylviasDaddy" is "thundering asshat." He does it because he has lost the argument. We shouldn't discriminate
A Magdalene Laundry US adoptee who holds no hatred for Irish nunsIt seems that if Mr. Cardosi had any compassion at all for his birth mother and what she went through, he would at least make a token effort to be &qu


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Media CoverageWe've updated our media coverage page to include all the Burning Man news that was (apparently) fit to print since the 2013 event. 10 Principles Blog SeriesWe are proud to announce the 10 Principles blog series, cornerstone of the Burning Man Project's Philosophical Center program. Join the discussion! Y.E.S. in Las VegasThe Youth Educational Spaceship project lands in Las Vegas on November 15, with family-friendly programming through December 8. If you're in the area, check it out! 2013/14 Burning Man Wall CalendarThe beautiful Burning Man wall calendar returns -- featuring a host of gorgeous photos -- for your gifting and/or nostalgic pleasure. Law Enforcement FeedbackWhether it was good, bad or ugly, if you had an interaction with law enforcement on playa this year, we want to know about it. This information is invaluable as we forge our ongoing relationship with law enforcement agencies. Please fill out a law enforcement feedback form! Read more news stories. Dec 12, 2013
Our marketplace has books, films, the official Burning Man 2013 Poster, the 2013-14 Burning Man Wall Calendar, and Dancing With the Playa Messiah, a beautiful book of Burning Man photography by George Post. |
Regional NetworkGet involved and stay connected to Burning Man culture year round via your local Regional Contact. The Jack Rabbit SpeaksSign up for the weekly, informative JRS email newsletter.Burner Social NetworkingConnect with Burners on Facebook and the ePlaya, and tune in to our @burningman and @blackrockcity Twitter feeds. SparkSpark is an online system connecting people with Burning Man projects, facilitating creative collaborations. Burning Man YouTube ChannelOur official YouTube channel features videos about the event and Burning Man's year-round culture. Tales from the PlayaOur collection of participants' stories from Burning Man over the years. We welcome your submissions! The Burning Man ProjectThe Burning Man Project's mission is to facilitate and extend the culture that has issued from the Burning Man event into a larger world by providing infrastructural tools and frameworks that will allow people to apply the Ten Principles in many communities and spheres of endeavor. Black Rock Arts FoundationOur sister non-profit brings the art and spirit of Burning Man into our daily lives through public art, community and civic participation. Donate now! Black Rock SolarBlack Rock Solar builds low- or no-cost solar power in underserved communities, while teaching people how to install renewable energy. Burners Without BordersBWB facilitates volunteers interested in manifesting Burning Man principles in the world by gifting their time and talents to help others. |


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POWNAL, VT. -- The Solomon Wright Library invites town and area residents to join in the 2012 statewide reading of Paul Fleischmnan's short fictional Civil War related novel "Bull Run." Chosen with the 150th anniversary of the Civil War years in mind, the book gives a "vivid, personalized portrait" of a war that became our nation's bloodiest conflict.
The first great battle of the Civil War is seen through the eyes of participants, male and female, Northern and Southern.
Copies of the award winning book in paperback, supplied by the Vermont Humanities Council, can be picked up during scheduled library hours.
On Nov. 11, at 1:30 p.m., Veterans Day, readers are invited to meet for readings/discussion led by Pownal resident Dawn Rodrigues. Share your views of the author's presentation of information, descriptions, the varied "participants" and more. Invite a friend and/or a neighbor who may or may not have read the book. Young readers (10 and up) and adults are encouraged to share in this poignant, thought provoking view of American history. For more info: 802-823-5400.


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Got my Second tattoo a while ago but never posted a picture. the Avril lavigne Let Go logo. This is 4 months old so not fresh but i like it a slight bit missing in the centre which needs to be filled in at some point when i can be arsed but what do you guys think?
Ive seen fans get this same tat and they never seem to get it accurate? Its always slanted, upside down, retarded or too fat/thin? Mine is the same as it should be though slightly thicker as im a guy and didnt like the oriignal, but its a minor increase. The wristband is from the black star tour in London sept 21st! Love it
Ps here is my first one i got ages ago, its been touched up since then (slightly bolder black outline but its lost its strong red colour )


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Important Traffic Bulletin:
Off and On ramps on I-10 between Prince Rd. (north of Tucson) and 29th St. (south of Tucson) are closed due to construction. In otherwords, no getting on or off the freeway through the main part of Tucson. This also includes the exits at Speedway.
The frontage road between Prince and 29th is a good option for those navigating into central Tucson. 3 lanes wide each direction and with full access to all major cross streets.
The freeway on/off ramps at Ina Rd and Cortaro Rd, where many have booked hotels, are open.


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At last, I have achieved my goal!
I recently had a comment exchange on Deviant Art:
http://pjarrett.deviantart.com/ (not a safe site, as my McAfee always reminds me...but they seem to have solved some of their problems...be careful, in spite of its name "Deviant Art" they allow underaged children to post right along with adults! If you're leary of the site...which I can't say I blame you...try my other blog at …
ContinueAdded by Philip Jarrett on October 7, 2012 at 5:08pm — 1 Comment
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Items where Author is "David , S. C. Yoong"
Group by: Item Type | No Grouping Jump to: Conference or Workshop Item Number of items: 1.
Conference or Workshop ItemYeok, Meng Ngeow; David, Maya Khemlani; David , S. C. Yoong (2010) Gender stereotypes in Malaysian Parliament: A content analysis. In: Proceedings of 2010 International Conference on Humanities, Historical and Social Sciences (CHHSS 2010), 26-28 February, 2010, Singapore. (Unpublished) |


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