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Pazopanib Hydrochloride in Treating Patients With Advanced or Refractory Solid Tumors
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This phase I trial studies the side effects and the best dose of pazopanib hydrochloride in treating patients with advanced or refractory solid tumors. Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Condition | Intervention | Phase |
Unspecified Adult Solid Tumor, Protocol Specific |
Drug: pazopanib hydrochloride Other: pharmacological study Other: laboratory biomarker analysis |
Phase 1 |
Study Type: | Interventional |
Study Design: | Endpoint Classification: Pharmacokinetics Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | Pharmacokinetic-Driven Individualization of Pazopanib Therapy in Patients With Solid Tumors: a Phase I Study |
- Biologically optimal dose (BOD) defined as the dose level and diet in combination that induces no toxicity requiring dose modification per protocol and achieves a satisfactory pazopanib trough concentration (Cmin > 30 μg/mL) [ Time Frame: At 14 days ] [ Designated as safety issue: No ]
- Time until any treatment-related toxicity as assessed by the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 [ Time Frame: 28 days ] [ Designated as safety issue: Yes ]The number and severity of all adverse events (overall, by dose-level and diet, and by tumor group) will be tabulated and summarized in this patient population.
- Time to progression according to Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 [ Time Frame: Up to 3 months ] [ Designated as safety issue: No ]
- Time to treatment failure [ Time Frame: From registration to documentation of progression, unacceptable toxicity, or refusal to continue participation by the patient, assessed up to 3 months ] [ Designated as safety issue: No ]
- Correlation between CYP and other polymorphisms with attained pazopanib levels in response to standard pazopanib dosing [ Time Frame: At baseline, at 24 hours after pazopanib and day 14 of course 1, and at 14 days of dosage change ] [ Designated as safety issue: No ]Descriptive statistics, simple scatter plots and linear regression model will form the basis of presentation of these data.
- Correlation between pazopanib levels with observed pazopanib toxicities [ Time Frame: 28 days ] [ Designated as safety issue: Yes ]
Estimated Enrollment: | 35 |
Study Start Date: | March 2012 |
Estimated Primary Completion Date: | February 2014 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Treatment (pazopanib hydrochloride)
Patients receive pazopanib hydrochloride PO QD on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Drug: pazopanib hydrochloride
Given PO
Other Names:
Other: pharmacological study
Correlative studies
Other Name: pharmacological studies
Other: laboratory biomarker analysis
Correlative studies
Detailed Description:
I. To assess the feasibility and safety of individualizing pazopanib hydrochloride (pazopanib) monotherapy based upon attained pazopanib plasma concentrations so as to achieve desired target pazopanib plasma concentration in the highest possible fraction of treated patients.
I. To assess whether patient cytochrome P450 (CYP) or other polymorphisms may correlate with attained pazopanib levels in response to standard pazopanib dosing.
II. To assess whether patient trough pazopanib levels attained 24 hours after initiation of 800 mg daily fasting may predict steady-state trough pazopanib levels after 14 days of pazopanib administration.
III. To assess whether patient trough pazopanib levels may correlate with observed pazopanib toxicities.
OUTLINE: This is a dose-escalation study.
Patients receive pazopanib hydrochloride orally (PO) once daily (QD) on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Patients undergo blood sample collection at baseline and periodically during treatment for biomarker analysis, pharmacokinetic, and pharmacogenomic studies.
After completion of study treatment, patients are followed up for 3 months.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Histologic proof of cancer which is now not amenable to alternative curative or clearly superior standard treatment options
- Measurable disease
- No known standard therapy for the patient's disease that is potentially curative or definitely capable of extending life expectancy
- No subjects with known brain metastases
- Hemoglobulin (Hgb) ≥ 8.0 g/dL
- Absolute neutrophil count (ANC) ≥ 1,500/μL
- Platelet (PLT) ≥ 100,000/μL
- Activated partial thromboplastin time(APTT) < 1.5 times upper limit of normal (ULN)
- International normalized ratio(INR) < 1.5 times ULN
- Direct bilirubin ≤ ULN (subjects with Gilbert syndrome and elevations of indirect bilirubin only are eligible)
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) ≤ ULN
- Creatinine ≤ 1.5 times ULN OR measured creatinine clearance of ≥ 60mL/min
- Urine protein/creatinine ratio < 1 or 24-hour urine < 1 gram
- < Grade 2 hypo/hyperkalemia
- < Grade 3 hypo/hypercalcemia
- < Grade 3 hypo/hyperphosphatemia
- < Grade 3 hypo/hypermagnesemia
- Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 or 1
- Ability to provide informed consent
- Willing to return to Mayo Clinic for follow up
- Life expectancy ≥ 84 days (3 months)
- Willingness to provide mandatory blood samples for pazopanib drug level assessments required for dosage adjustments, as well as for required pharmacogenomic studies
- Women of childbearing potential only: Negative serum pregnancy test done ≤ 14 days prior to registration
- No uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- No QTc > 500 msec and/or receiving any concomitant medications that are associated with a risk of QTc prolongation and/or Torsades de Pointes; these medications should be discontinued or replaced with drugs that do not carry these risks
No subjects with any of the following cardiovascular conditions within the past 6 months
- Cerebrovascular accident (CVA) or transient ischemic attack (TIA)
- Admission for unstable angina
- Myocardial infarction
- Cardiac angioplasty or stenting
- Coronary artery bypass graft surgery
- Pulmonary embolism, untreated deep venous thrombosis (DVT) or DVT which has been treated with therapeutic anticoagulation for less than 6weeks
- Arterial thrombosis
- Symptomatic peripheral vascular disease
- Class III or IV heart failure as defined by the NYHA functional classification system; a subject who has a history of Class II heart failure and is asymptomatic on treatment may be considered eligible
- Active cardiac arrhythmia (except sinus arrhythmia, atrial fibrillation, asymptomatic premature ventricular contractions [PVCs])
- Ejection fraction < institutional lower limit of normal (LLN) and/or history of cardiomyopathy
- No blood pressure (BP) > 140 mm Hg (systolic) and > 90 mm Hg (diastolic); initiation or adjustment of BP medication is permitted prior to registration provided that the average of three BP readings at a visit prior to registration is < 140/90 mm Hg
None of the following:
- Pregnant women
- Nursing women
- Men or women of childbearing potential who are unwilling to employ adequate contraception
- No immunocompromised patients (other than that related to the use of corticosteroids) including patients known to be HIV positive with CD4count < 200/μL
- No other active malignancy ≤ 3 years prior to registration; EXCEPTIONS: Non-melanotic skin cancer or carcinoma-in-situ of the cervix; NOTE: If there is a history or prior malignancy, they must not be receiving other specific treatment (e.g., hormonal or chemotherapy) for their cancer
- No co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens
No subjects with any condition that may impair the ability to swallow or absorb oral medications/investigational product including:
- Any lesion, whether induced by tumor, radiation, or other conditions,which makes it difficult to swallow capsules or pills
- Prior surgical procedures affecting absorption including, but not limited to, major resection of stomach or small bowel
- Active peptic ulcer disease
- Malabsorption syndrome
None of the following conditions:
- Serious or non-healing wound, ulcer, or bone fracture
- History of bleeding disorder, including patients afflicted with hemophilia, disseminated intravascular coagulation, or any other abnormality of coagulation potentially predisposing patients to bleeding
- History of hemoptysis in excess of 2.5 mL (½ teaspoon) within8 weeks prior to first dose of study drug
- Poorly controlled depression or anxiety disorder, or recent (≤ 6months) suicidal ideation
- HIV-positive patients on combination antiretroviral therapy
No subjects with any condition that may increase the risk of gastrointestinal bleeding or gastrointestinal perforation, including:
- Active peptic ulcer disease
- Known intraluminal metastatic lesions
- Inflammatory bowel disease (e.g., ulcerative colitis, Crohn disease) or other gastrointestinal conditions which increase the risk of perforation
- History of abdominal fistula, gastrointestinal perforation, or intraabdominal abscess within 28 days prior to beginning study treatment
- No failure to fully recover from acute, reversible effects of prior chemotherapy (other anti-neoplastic therapy) and radiation therapy
- Not receiving a medication with known risk of torsades de pointes; the following medications are specifically prohibited: amiodarone, arsenic trioxide, bepridil, chloroquine, chlorpromazine, cisapride, clarithromycin, disopyramide, dofetilide, dolasetron, droperidol, erythromycin, halofantrine, haloperidol, ibutilide levomethadyl, mesoridazine, methadone, pentamidine, pimozide, procainamide, quinidine, sotalol, sparfloxacin, and thioridazine
None of the following therapies:
- Chemotherapy ≤ 28 days prior to registration
- Mitomycin C/nitrosoureas ≤ 42 days prior to registration
- Immunotherapy ≤ 28 days prior to registration
- Biologic therapy ≤ 28 days prior to registration
- Radiation therapy ≤ 28 days prior to registration
- Radiation to > 25% of bone marrow
No current use of therapeutic warfarin
Low molecular weight heparin and prophylactic low-dose warfarin (INR < 1.2 times ULN) are permitted
- Prothrombin time(PT)/partial thromboplastin time(PTT) must meet the inclusion criteria
No other concurrent chemotherapy, immunotherapy, radiotherapy, or anyancillary therapy considered investigational (utilized for a non-Food and Drug Administration [FDA]-approved indication and in the context of a research investigation)
- Concomitant use of zoledronic acid, pamidronate, or denosumab is allowed (and can be initiated while patients are on study therapy at investigator discretion)
- Not receiving any other investigational agent
- No prior use of pazopanib (prior use of other kinase inhibitors allowed)
- Not receiving any medications or substances that are strong or moderate inhibitors of CYP3A4 (indinavir, nelfinavir, atazanavir, ritonavir,clarithromycin, itraconazole, voriconazole, ketoconazole, nefazodone, saquinavir, telithromycin, aprepitant, erythromycin, fluconazole, grapefruit juice, verapamil, diltiazem); use of the aforementioned strong or moderate inhibitors is prohibited < 7 days prior to registration
- Not receiving any medications or substances that are inducers of CYP3A4 (efavirenz, nevirapine, carbamazepine, modafinil, phenobarbital, phenytoin, pioglitazone, rifabutin, rifampin, St. John wort); use of the aforementioned inducers is prohibited ≤ 7 days prior to registration
- Not receiving mitotane within 6 months of enrolling on the study
United States, Florida | |
Mayo Clinic in Florida | |
Jacksonville, Florida, United States, 32224-9980 | |
United States, Minnesota | |
Mayo Clinic | |
Rochester, Minnesota, United States, 55905 |
Principal Investigator: | Keith Bible | Mayo Clinic |
No publications provided
Responsible Party: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT01552356 History of Changes |
Other Study ID Numbers: | NCI-2012-00690, NCI-2012-00690, CDR0000727235, MAYO-MC1112, MC1112, 9076, U01CA069912 |
Study First Received: | March 9, 2012 |
Last Updated: | December 6, 2013 |
Health Authority: | United States: Food and Drug Administration |
Additional relevant MeSH terms:
Neoplasms |
ClinicalTrials.gov processed this record on December 10, 2013


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In the wake of Monsignor William J. Lynn's conviction Friday of endangering the welfare of a child and Lynn's bail being revoked, Philadelphia Court of Common Pleas Judge M. Teresa Sarmina said during a hearing Tuesday that she would consider releasing Lynn on house arrest if Lynn would waive his right to fight extradition and if it could be established that the Vatican would honor such a waiver.
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For Now, Judge Holds Off on Lynn's Request for House Arrest
The Legal Intelligencer
June 27, 2012
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4 hrs ago | Groton Landmark
In 1932, Clarence L. Thompson, Stephen W. Sabine and Everett B. Gerrish were the Groton Assessors.
What Do You Know About Conspiracy Theories?
When should abortion be legal?
5 hrs ago | Nashoba Publishing Online
Dec. 2: 3:17 A-1 ALS Groton; 4:56 A-2 to 8 Pingry Way; 7:10 A-1 to Nashoba Park; 8:57 A-1 ALS Groton; 12:12 A-1 to Main Street; 12:19 Box 343, Nashoba Park, Engine 2, Ladder 1 responding; 14:20 A-1 to 37 Markham Circle; 14:39 A-2 to 18 Pond St.; 15:40 A-1 ALS Shirley.
Annual G-DRHS Art and Craft Fair This Weekend
The G-DRHS Art Club is hosting its 2nd annual Art and Craft Fair to celebrate the 2013 holiday season this Saturday, December 14 from 11 a.m. - 5 p.m. at the high school, 703 Chicopee Row, in Groton, MA.
Groton senior-citizen volunteers sought for cable show
The Groton Council on Aging and the Groton Channel are encouraging senior citizens age 60 and older to volunteer as camera and equipment operators for the council's monthly TV program.
Christmas Tree Lighting Brightens Groton Center
About 30 people braved some snow and a biting wind Sunday afternoon to sing carols and light the town Christmas Tree on the common across Main Street from the Union Congregational Church.
An interesting African perspective on Mandela
The author, Temba Maqubela is headmaster at Groton School in Groton, Massachusetts.
Playing Santa for the love of a childhood pal
Leong, 15, is a freshman at Lawrence Academy in Groton and at the tender age of 6, she learned the meaning of loss and heartbreak.
Blind Philanthropist Says Cure For Blindness Is In Sight
Gordon Gund has devoted much of his life to fighting blindness, helping to raise $550 million for the cause.
Dear Editor: Another Response To Lost Lake Problems
I'm trying to understand why some town leaders in Groton are refusing to follow the advice from multiple highly-paid scientific professionals to sewer the Lost Lake area.
Nashoba Publishing/Dina Samfield Aaden Tores, 5, helps to unpack thousands of pounds of food for the Shirley "Scouting for Food" drive.
Area-Wide Holiday Toy And Decorations Swap Tommorrow in Groton
Tessa David, Groton Recycling Committee Chair, explained the idea in an email: "The Groton Recycling Committee started our Groton FreeCycle and then our grassroots, FreeStuff groups to help find new uses for too good to trash stuff.
Nov. 19: 6:52 A-1 ALS Shirley; 10:35 A-1 to 1 Columbia St., Post Office; 21:14 A-1 to 55 Littleton Road Nov. 20: 9:19 A-1 ALS Shirley; 10:15 Engine 2 to 35 Groton School Road for an alarm activation; 12:53 A-1 to area of Carlton Circle for an motor-vehicle accident; 13:40 Engine 2 to Nashoba Valley Medical Center for an odor investigation.
COLCHESTER, Vt. -- The following local residents were named to the spring 2013 dean's list at Saint Michael's College, a liberal arts and sciences, residential Catholic college located in Burlington, Vt., one of the top 10 college towns in America: Scott J. Feenan, son of Catherine and Scott Feenan of Groton, Mass., a senior psychology and ... (more)
Dear Editor: Enough Lost Lake Water Testing Has Been Done. It's Time To Act.
I don't see the point of spending more money to do more water quality testing. Groton has been studying these very same issues, spending taxpayer dollars, since the 1970s with results confirming that septics are impacting both the Lake and drinking water.
Psst Wanna Buy A Fire Truck? How About a Fire Station?
If you're dreaming of getting a fire engine as the perfect holiday gift - a real fire engine, mind you - not a toy, your dreams could come true Tuesday December 10. If you dream a little bigger and you've been very good and not at all naughty you could end up with a whole fire station.
Residents aid Scouts in delivering the goods
Truck number three was the third truckload of nonperishable food collected throughout the town of Shirley by area Scouts on Nov. 10. The truck was soon on its way to Loaves & Fishes Food Pantry in Devens, and by the end of that Sunday afternoon, eight truckloads, or nearly 7,500 pounds of food, would be delivered to the charitable organization.
ANON ALCOHOLISM SUPPORT: For those whose lives are affected by another person's drinking; meets each Fri., 7-9:30 p.m. at Lowell General Hospital, Hanchett Auditorium, Varnum Ave., Lowell; each Sat., 9:30-11 a.m. at Immaculate Conception School, 218 E. Merrimack St., Lowell.
Dear Editor: Should Groton Offer Free Well Testing Around Lost Lake?
The Town of Groton has long wrestled with the idea of building a sewer system to serve the Lost Lake area.
Buyer for Groton fire station sought
With the construction of the new Center Fire Station on schedule, selectmen are preparing to sell the existing firehouse on Station Avenue with one goal in mind: Igniting downtown makeover fever.
Groton Woman's Club's green machine ready to deck your halls
The holiday season begins for Pat Bennett every year when she takes a step into pine-aroma-filled Williams Barn off Chicopee Row.


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You're watching...
Mega church pastor sparks faith debate
Justin Bieber's pastor Judah Smith asks the question what Jesus means to you
Feb 26, 2013
Judah Smith
You're watching...
Justin Bieber's pastor Judah Smith asks the question what Jesus means to you
Feb 26, 2013
Judah Smith
Also in this playlist...
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Auto-advanceThis transcript is automatically generated
-- Let's -- a little bit about religion because there is an interesting.
Book out all Jesus is blank by.
Judith Smith who is a pastor and -- this year by the way the subtitles on a new way.
To be human wanna talk to him now about this by way of -- -- -- on me just read your introduction.
In the book because I really liked it.
I'm 33 years old I was born and raised in the Pacific -- -- which means I'm addicted to coffee and complaining about the whether -- my husband a father -- three an -- golf from also what pastor in this last bit.
Makes people feel awkward because you go onto its funny stereo -- you write and I suppose to some extent.
Jesus get stereotyped.
Yeah -- no question about it I think people assume that well I'm always gonna say before he says it.
I know he is premise that he's working from men and hopefully did this this project is a little bit demystified unpacking.
Some of those.
You know us assumed premises that -- who allowed people to dialogue and converts a little bit.
So what did you find out -- this started out regionally.
As sort of a project what in -- perished in the new expanded it to what the Seattle area -- -- would billboards as before he had just started -- really trying to get its the dialogue and conversation about -- -- -- -- Seattle one of the most -- regions -- the United States of America.
And before we knew it it kind of caught fire in terms on the web site people sort of filled in the blank tens of thousands of people and so billboards went up and bumper magnets and it's been pretty cool to see the conversation in a place like Seattle.
About Jesus where oftentimes he's not talked about much and Justin Bieber gave you a big boost -- that happened.
Well have been able to be in -- life for about three years now and that is believed in love them and Kurds and they and to try to try to be there Foreman and he claims means this -- are so grateful for that yet well when he.
Went on to social media and started talking about you and this project.
I mean all of a sudden it just exploded.
He had idle idol they get hurt and they really have been -- that -- started writing this book about three years ago.
That Justin was certainly in mind as I wrote it for sure and what about one of my favorite golfers on the PGA -- Obama.
Who won the masters tonight you know he cried.
And when he cried I cry we're talking about bubble watch that's right from while I was there right but it where Easter weekend yeah -- a while I was there till Friday.
Well you know I hug him and say it's going to be special weekend and so Sunday afternoon after church on Easter I'm going how it might not there.
-- -- this ticket is not Easter but.
-- pretty special to see what your best friends win though the biggest golf tournament the world.
He would wrote an inner -- here forward.
And it's very nice and he's such a great guy he really is he has an inspiration.
Everybody if any but he knows his life story.
Obviously it is incredible and I hope he wins the masters again from the tip of -- coming up in April that's because I'm up tell me what you -- Found down from various.
Of different faiths and different religions and their take on -- I think -- -- -- is very apparent that he's the most compelling figure in human history no matter what persuasion you are in terms of your.
Your thoughts on god his existence or lack -- he seems to be incredibly compelling and rightfully so.
-- I think I think everybody wants to be heard and my -- much premises so you know let's have a conversation and let's hear from what you have to say and frankly.
I think no matter where you're coming from -- in the religious landscape we have a lot to learn from each other no matter what convictions we hold.
Listening to one another is is never a bad thing and it certainly has been eye opening to see the bullets filled in by different different viewpoint.
I must tell you this is a fun read and and I used that word -- in the most realistic sent us here here's a passage on page 122 financing titled Jesus laughing.
Some people can't understand how god -- happiness could go together they think religion and -- are fundamentally opposed to them Gaza.
God has a cosmic party Cooper -- grinch.
A spoil sport god is against parties in fun and -- -- god is the antithesis of happiness.
Nothing could be further from the truth.
Nothing could be further from the look at all of creation -- god indeed Israel he is the creator he's the ultimate artists.
He's the ultimate stand up comedian he has a sense of humor.
A look at -- civilian work we're -- funny creatures and so I think if you -- if you really believe in god and and obviously have to do I do with all my heart.
I think he's got an extraordinary sense of humor and -- that's why he gave us one.
Now let's put up on the screen we have a few of the -- fill in the facts and I think you'll like this.
So Jesus -- -- supposed to fill in the blank and you know here's -- we got rebel without cause admit them profit.
A loving UN spy did view the only way not a religion.
Once said -- Republican -- -- The idea that that Bob.
Here views here -- -- no question and that's where I think there's so much to be said about Jesus and we have.
A great opportunity here to really start a conversation that obviously I believe is not only compelling.
The critical.
In human existence you know look like a pastor from a the hot hot headed into its JB wrote it wrote it off on the you know it could being that I could -- I am having your hairstyle is is more like Justin Bieber and and I've heard that.
In your.
Your attire and so -- course on Sundays you've probably Wear something a little bit different I've got to admit this is this is of this -- -- my Sunday best.
But I'm not afraid of suits but -- maybe it's just the Seattle culture dizzy.
Help you to reach out to younger people.
To me I think young people -- -- inspire and I still like -- still young but at 34 I'm definitely not a TV -- your district and the I -- But.
You know what I love about young people is their honesty in their transparency and I think this project.
Is very appealing to young people because they're going to be very candid about that -- and -- it's it's moving stuff and it's very enlightening and challenging for me.
-- your website is -- Jesus is -- dot com is book dot com.
OK but there was a dot org is their doctors are dead and it did that the website that's just about the Blake.
Which is the most part -- the most compelling as Jesus despues -- out of work time.
And folks can find his book through the web site or -- -- -- or wherever books are sold Barnes & Noble and circuit for you have to do so for.
A bit they're pretty pleased it's it's climbing the charts they tell me but -- I'm just excited images it's a big deal.
Well you're doing a good job -- -- -- you.
And I -- Smith for joining us after Judith Smith -- best of luck to you thank you need to institute.
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The Post-9/11 GI Bill provides financial support for education and housing to individuals with at least 90 days of aggregate service on or after September 11, 2001, or individuals discharged with a service-connected disability after 30 days. You must have received an honorable discharge to be eligible for the Post-9/11 GI Bill.
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Queens, Brooklyn bus riders to get new routes
New bus service for Queens and Brooklyn will begin early next week, the MTA said.
The new routes were funded by a $29 million investment the MTA made last summer, after the agency had to deliver a major cut to service in 2010 to close a deficit.
"These new and extended routes will go a long way towards providing better service to our customers in Brooklyn and Queens," said... » more


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Skylanders: Swap Force was one of my biggest surprises of the year. After two full iterations in such a short amount of time, I didn't think Vicarious Visions had it in them to make the strongest one yet. But here we are, and it seems as if the Skylanders train is taking off yet again with solid early sales.
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The Writing Center provides peer support for student writers on all types of writing projects in any subject. Students also use the Writing Center for personal writing, application essays, resumes and cover letters. The Writing Center does not proofread or correct papers; writing assistants work collaboratively with writers offering feedback and providing ideas and methods for editing and polishing their work. Our goal is to provide writers with transferable skills that will help them on future writing projects. We also provide students with additional resources such as dictionaries and grammar handbooks, textbooks, handouts, exercises, and instructional software for composing, editing, punctuation, and grammar basics.
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View potential medicine hazards by room and learn how to prevent them.


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text:
No One-Liners, Atleast a Paragraph Please.
Keep Me Updated, Let a lady know when you're not gunna be able to post for a while.
Romance is encouraged if that's the direction the story takes, but no smutty stuff please.
If you're going to lose interest in the RP a week after it's conception, don't bother.
That should sum it up!
My name is Anderiel, and I'm new to the forum only been here for almost a month actually. But this isn't an introductory post, it's an interest check- so let's get on with it. I am a horror junky to the core, but fantasy and other genres are to my liking to. I'm an experienced Roleplayer, literate, and I've just joined this forum so I'm looking to keep myself busy by any means necessary- and I mean by any means. But here's the gist of what I'm looking for/to work with, Male or Female doesn't matter to me, just looking for an experienced writer or writer[s] to spark up some 1x1s with me to keep me busy when I'm not investing in other RPs I'm in. Now, to the brief list- and then shortly after some broad plots that I have up my sleeve.
- Pairings List -
Murderer x Witness
Neighbor x Neighbor
Classmate x Classmate
Demon x Human [but only if the plot is good enough]
Zombie x Human
Sorcerer x Necromancer
Human x Ghost/Spirit
Open to Suggestions Also!
- Plot List -
Just a normal day of school like no other, classmates gossiping amongst one another, boys gawking at girls, teacher lecturing in that same basic tone. But today wasn't a normal day, that girl you've always secretly admired was staring at you from the back of the room. What was different about you today, what was she thinking, why was she looking today of all days? Suddenly more strange things begin to happen, when she finally approaches you questions arise. She was different than before, something about her has changed, and when other people in the class begin to notice things go awry and you are dragged into the middle of an event that could become the worst school year of your life, and could possibly result in the end of your life.
Yr: 2096
We have become god, giving life was supposed to be grounds not meant to be tread by man. But again in the garden of eden we have pulled the golden apple from a forbidden tree, and so brought forth the AI. When first created they were merely workers, laborers, some even slaves. But as technology developed they eventually progressed, and now live alongside man as the equals they have always fought to be. But what if there were people who wished to change this, people that saw our creations still as inferior and preferred our children of existence to remain slaves and pets. As a human falls in love with an AI, this troublesome deluge behind the curtain encroaches on their happiness, pulling at the seams of their lives.
The Contract
Myth is a touchy topic, especially the oldest of stories. Sometimes people can't say where or when they originated, or simply that they've always been there. But what if it was true, what if things of fairy tale squandered amidst outside of sight, or even right under our noses. For an unlucky human, they found this reality and the horrors that followed. What at first seemed to be a typical assault on a victim ended up being much more, and as webs begin to weave between a savior and their rescuee- one would begin to wonder why they were attacked, and if they should really trust them.
Well, that's it! If you are interested or have any ideas feel free to PM and we can certainly discuss things!


text: hey i accually got an MRI which didn't show much because of the screws...but it did show tendinitis...which was causing the lump??? but after a week in a cast(for the wound) the lump was gone!!!But, this morning i got another lump from the outside of the tendon that was dark blue and quite large...ideas...non. but i'm having the screws removed on wednesday(along with some other things) so i will let you know if they find out what it is/washave you had any pics? and how long has it been there?


text:
Hi Fits I'm sure that there are several lists floating around. Here is one http://www.hardwarecanucks.com/forum/hardwarecanucks-f-h-team/46010-hwc-folding-home-project-ppd-database.html The future of CPU and the big points are AMD 4P rigs. Thats at least the cheapest solution. A high end Intel based 4P would trash it but the investment is out of reach for most. The new (beta) WUs for +16 treaded PC is now released and that will be the next bigadv.
i just have a i5 655k and soon a ati 6950. i just need a decent cpu cooler to get started. this stuck one wont cut it for 100% cpu load i'd post in the pay it forward thread but im afraid i'll get attacked as usual despite me being the one who started the TPU WCG team. im not looking for praise here but some respect would be nice. i do thank you for your help though.
Well in other news, the democrats of California in their infinite stupidity and never ending quest for more of my hard earned money, have decided it's okay to charge people with solar panels $70 extra a month and charge me double for any non solar electricity I use. So the money I was saving by my solar panels is going out the window, making it impossible for me to continue to fold. This is not official yet, but it is highly likely that this will become reality. So IMO it's not a matter of but when, I will have to stop folding, I am committed to reaching the 5 million mark, but after that I am likely done, unless by some miracle this does not become reality. I really am sad that I will have to stop, but I will keep you posted one way or the other.:shadedshu
time to buy a windmill and go completely self sufficient. thats ridiculous to charge people with solar panels a surcharge. they should give you a discount for being better for the environment. do they give a tax credit for having a solar panel? i've heard of some people actually getting paid for electricity because their windmills actually put power back into the grid.
The power company for San Diego (SDG&E) takes any surplus I put into the grid, but I do not get payed for it. I did get a large tax credit and a rebate when they were installed, but that only applied to the cost of the panels not the electricity or the installation. It's really demented that I am being punished for using less electricity. As for a windmill, even if I could afford one of ample size and output for my needs, it's highly unlikely there would be sufficient wind for it, let alone that I would be allowed to have it or that I am even zoned for it. It's sad times indeed, I want to go back to Texas!
ME TOO! im moving to Dallas this fall. apparently a few other people from TPU are planning on heading to texas too so i've heard.
Fits, for Chimp, I had my i5-650 @ 4.2 (H-50, never got over 40C) and got 5-5500 PPD while running a GTX460. You have to use the V7 Client for that 6950.
thats ridiculous, and extortionate , if it were me though id create a small power bank(of batteries obv) that the panels fed into then invert that into a seperate mains loop to run folders on ,and as far as the elecy co go they wouldnt know about it or id have it removed either way id then pay less. IMHO thats how solar and wind should be used anyway as local power , and just used to power low voltage lighting throughout the house plus a constant low power water conserve boiler on perma heat, plus whatever other houshold items it had the juice to feed then have mains just for the kettle and cooking
If my country adopted that policy (no return into the grid/no pay for surplus) we would lose 12 % (wind mills alone, 2011 figures) of our electricity production. No one would ever erect a new 3 MW mill and the existing ones would die out. Not sure that would be a good idea but I don't live in the free world with nuclear power forced down my thought This discussion is not in the right forum. Just sad that some will stop folding because of stupid rules.
Are you folding with what is on your system specs? I just received a P8XXX -bigadv on my SR-2 w/ dual X5670 (@ 4.0Ghz) running ubuntu linux. I've yet to verify the PRCG info since HFM.net is not tracking it yet.
If it were a (beta) 8101 kill it. 50% points. Plenty of post on that one around [H]. Edit: Beta testing seems to be done after a very short alfa ditto inhouse. They really got it wrong this time. It is normal that they send beta to non-beta tester (by mistake?) but here (non beta forum) they act like the receiver is a criminal. I'm no longer in the 4P shopping mode, amateurs and you know how I'm pointing at.
Just a heads up, I'll have to break down my 2 folders on the 13th, and put them back up on the 15th. New owners of my building. They want to do a walk through on the 14th, and I don't want them to see, and feel, my folders. People don't seem to care if you want to cure cancer!
It talks about it here: http://foldingforum.org/viewtopic.php?f=66&t=20717 I'll let it complete and hopefully pick up a 6903/04 afterwards
I am now looking for 2 used 470s. My 285s need to go to my folding box now, it's time. Please any offers.
Hardware Alert Newegg has a Shell Shocker starting at 6:00PM EST, 3:00 PST on Refurbished GTX 560TI's. Don't you have that backwards? There were 3 GTX470's on my local CL, 1 for $100, and a matched set for $260.
My son is going to be away for the weekend, so I decided to get SMP going on his system. During the CC, that i5-650 at 4.2GHz got 5000+ PPD. It's only clocked at 3.2 GHz now, but what is the first WU that it got? An 8011. 90 PPD! Good-bye, SMP. Edit: I did not have my passkey in the client, so that may have affected the points because it would not have included the bonus points.
That GTX 560TI is $160, free shipping. 1Yr ESP Included, upgrade to 2Yrs for $9.99, ends 2/10. Edit: They're gone
It sure looks like there was a points correction in this latest no-points then points update. Mine should have been around 20,000 but was almost 41,000.
Bogmali, I just got the invite to Cloud Services and set up my account. What are the setting in the dashboard you are using? Total Linux nooby here. edit: looks like i'm limited to 20gb ram, so no 8 core instances.


text: Inducted 2010 Art Fry was a new product development researcher at 3M when he learned of the adhesive microspheres that his colleague Spencer Silver had developed. The spheres were pressure-sensitive, but had a low degree of adhesion. He coated paper with the adhesive and made repositionable notes, and the concept of Post-it® Notes was created. Invention Impact Years of perfecting design and production followed. Major challenges involved creating equipment and processes to manufacture the notes, as well as the problem of getting the adhesive to stay in place and maintain a consistent range of adhesion. Inventor Bio Born in Owatona, Minnesota, Fry graduated from the University of Minnesota and spent his career at 3M until his retirement in 1992. He made many technical contributions to 3M products, including art materials, tapes, decorative ribbon and gift wrap, and metal surface-finishing laminates. He was admitted into 3M's Carlton Society in 1983, the highest honor given to a 3M scientist. |


text: Erin Wasson Brings RVCA Party to the Tents for Spring 2010 September 12, 2009 Share This link 26 / 73 by POPSUGAR Fashion News 0 Save 0 Favorite 0 Previous 26 / 73 Next by POPSUGAR Fashion News 0 What's Your Reaction? 0 0 0 0 0 0 ‹ Back to Homepage Save 0 Favorite 0 Follow POPSUGAR Fashion Pinterest Twitter Google + Instagram Featured Partners Jackets That'll Make You Hope for Cold Weather Fashion Faceoff: Adriana vs. Sandra I Really Love My: Keira's Wedding Dress and More! You Asked, We Found: Emmy's Necklaces and More More News at People StyleWatch Beyoncé Just Dropped an Album With No Warning See: Flash Mob Ballet at Van Cleef & Arpels The Year in Street Style: Céline Wins! The Best and Worst of December Fashion Magazines More News at The Cut Jane Birkin's Daughter Kate Barry Found Dead The Style Evolution of Erykah Badu, the New Face of Givenchy See Every Look From the 2013 Women in Entertainment Breakfast Amy Adams Resurrects the Comb Headband at American Hustle Premiere More News at Styleite popsugar live! NOW Watch POPSUGAR LIVE! Now NOW Watch POPSUGAR LIVE! Now Sponsored Links Subscribe to POPSUGAR Subscribe now to get instantly addictive email delivered to your inbox! Daily Sales & Arrivals Celebrity & Entertainment Featured Shops Fitness Fashion & Beauty Living Must Have ShopStyle Search Top BrandsLucky BrandForever 21BurtonTimberlandAldoNARSLe LaboJunk Food Top Searchesdogeareddesigner handbagshush puppieswedding dressankle boots for womenhalter topthe game of lifejones new york


text:
All Trips & Travel Tours in Botswana
Supersized Africa
Botswana, Kenya, Malawi, Namibia, Rwanda, South Africa, Tanzania, Uganda, Zambia, Zimbabwe
If you only take home one piece of African wisdom let it be this: 'The buttocks are like a married couple. Though there is constant friction between them they will still love and live together.'
Caped Crusading
Botswana, Kenya, Malawi, Namibia, South Africa, Tanzania, Zambia, Zimbabwe
Game drive tips:
- Repress your inner fashionista and stick to neutral colours. Neon might be in this year but the animals hate it.
- Remember your truck...


text:
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text:
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text:
NMP is an abbreviation for:
nucleoside monophosphate
Find a translation for NMP in other languages:
Select another language:
Use the citation below to add this abbreviation to your bibliography:
"NMP." Abbreviations.com. STANDS4 LLC, 2013. Web. 12 Dec. 2013. <http://www.abbreviations.com/term/1414908>.
NMP also stands for:
- N Methyl Pyrrolidone
- N-Methyl Pyrrolidone
- National Maintenance Point
- National Media Pool
- nerve-muscle pedicle
... and 17 more »
Nearby & related abbreviations:
Alternative search:
- Search nucleoside monophosphate on Amazon.com
- Search nucleoside monophosphate on Google


text:
News Archive
This news archive provides a backlog of past news, events, press releases and investigations. Go here for the most current updates.
October 2011 News Update
The leaves have died, but our sense of skeptical curiosity remains alive and well! Our star-watcher returns, and former claimant Anita Ikonen announces she will soon "go woo." As we wave goodbye to Anita's various "contributions" to skepticism, we can take solace in our awesome new Clairaudient Test video! Links and more inside our October update.
September 2011 News Update
And the award goes to
IIG's September News Update! Read about our recent "Iiggy" Awards Show honoring Ray Hyman, Bad Universe and more, view pictures from our fantastic (and highly exclusive) annual party, and see Jim Underdown probed live on stage by a miniature UFO. Also in this update: Dragon*Con finishes with a roar, Mark & Susan communicate with the undead, and several IIG members and friends land some fantastically shameless plugs for the group. Happy autumn, everyone!
August 2011 News Update
What does Clairaudient Claimant Phillip Lee have in common with a vicious honey badger? They both feature prominently in our August News Update! More info on these, our Steering elections, and other fascinating IIG projects available inside
with pictures, too!
May 2011 Public Update
Initial report of our Nick Nelson Preliminary Demonstration, several IIGers have fun during the "Rapture" on Hollywood Blvd, and we are getting ready for TAM 9 from Outer Space!
Robbie Thomas and "Psychic Justice"
June 2010 - IIG Investigator Jarrett Kaufman reports on The BadCast about the self-proclaimed psychic Robbie Thomas.
Listen to episode 14 here, and then read these supplemental materials:
- The Caughlin Family Statement about Robbie Thomas
- Letter from a member of the group behind Stoprobbie.com
- Official Statement by John Ramses of Labyrinth Entertainment for why he ended all dealings with Robbie Thomas
February 2010 Public Update
Regen Traynor arrives for a preliminary demonstration of his claim that he can send information telepathically to a receiver. Also, bomb detection frauds, a big development on the anti-anti-vax front, Chicago "paranormal" cops, a sweat lodge guru arrested, and more!
November 2009 Public Update
Anita comes to town for a preliminary demonstration of her claims that she can see inside the human body without the aid of an MRI or X-Ray machine. Update on CBRN (California Board of Registered Nurses) and CFI Care, and more information on a few more possible applicants.
October 2009 Public Update
Some of our IIG members have been in the media, UCLA recently got a bad case of the woo, and we've posted new articles on some of our old investigations.
September 2009 Public Update
A lot of news this month! Find out the latest about the California nursing board, the IIG Awards, Vision from Feeling, the Rocky Mountain Mirror Man, Jenny McCarthy's body count, a Hollywood Reality Check,
some UCLA campus quackery, and a some newly posted investigations from the
IIG vault.
July 2009 Public Update
Updates on the California Board of Registered Nurses, some quackery at the UCLA campus, the IIG Awards, Connie Sonne's test in Las Vegas, and our ongoing protocol negotiations with Vision from Feeling.
May 2009 Public Update
Nursing presentation results, the IIG Awards, Vision from Feeling, a Colorado Psychic, and Connie Sonne are all in the news.
The 2009 IIG Awards
May 18th, 2009. Honoring Joe Nickell, Bill Maher, Amanda Peet, Lewis Black, Mythbusters, and more! With presenters Paul Provenza, Dana Gould,
Kathleen Madigan and Frank Conniff. Get
tickets here.
April 2009 Public Update
Two very important IIG events are coming up! Find out more about our nursing investigation on April 5th, and the IIG awards on May 18th.
February 2009 Public Update
Nurses learning Feng Shui? A new psychic contact? Read more in the February update.
January 2009 Public Update
Word telepaths and medical diagnosers and UFOs, oh my!
December 2008 Public Update
We've got news on a couple telepaths, a spoon bender, feng shui in the
Burbank Police Department, the ongoing communication with our Vision from
Feeling contact, and more.
The Billy Meier Case
IIG's coverage of Billy Meier's claims has been greatly enhanced with new reports by investigator Derek Bartholomaus.
Visit the new Billy Meier page, or
read the press release.
November 2008 Public Update
What do skeptics do on Halloween? What comes from Denmark and claims to
identify strangers with a pendulum? Is one of our investigators a
disinformation specialist from Washington DC? Learn the answers to
these tantalizing questions in our montly update.
October 2008 Public Update
All the latest on the Billy Meier case, the Montana Vortex, Scientology in our backyard, Vision from Feeling, and a
skeptic from Africa who contacted us for help.
The See Clearly Method Investigation
Our 2005 investigation, recently updated, of a product claiming to improve vision.
September 2008 Public Update
Read about the IIG annual barbecue, the New Zealand Orb Man, more emails
from Michael Horn, Colonel X in Nevada, the republished Aulterra
Investigation, and the New Jersey Spoonbender.
August 2008 Public Update
More on the IIG Awards, Michael Horn's flurry of emails, and some
possible upcoming investigations.
June 2008 Public Update
We've got healers from Calgary and Long Island, a Tennessee telepath, a Street Fair to attend, and updates on our investigation of Aulterra.
IIG Awards Press Release
Get the full scoop on our upcoming 2007 IIG Awards on June 23, featuring James Randi, Paul Provenza and Dana Gould.
Visit the IIG Awards website here.
May 2008 Public Update
The latest on some of our ongoing investigations, as well as news on our
recent ghost investigation, a disaster averted, our participation in a
marijuana movie (it's not what you think), the Airborne Health Settlement,
and the upcoming IIG Awards featuring an amazing guest.
April 2008 Public Update
Find out what's going on with the Long Island Healer, the Golden Vortex, Vision from Feeling, and some of our
other ongoing investigations. Also, the alien autopsy rears its rubber head.
Fullerton Phantoms
Our 2005 investigation of a family who reported various phenomena including orbs,
nighttime noises, doors opening and closing, strange movement and a ghostly
March 2008 Public Update
News on the Long Island Hero, Billy Meier's UFOs, a Canadian Lottery Master, recent website updates, and more!
February 2008 Public Update
Read about The Daughter who sees in the dark, the updated $50,000 challenge application, the Long Island Healer,
UFOs on DVD, IIG's 8th birthday, and Vortexes in Montana.
IIG on KCET's Life and Times
On December 19th, in its final week of broadcast, KCET's Life and Times ran a news story on IIG and CFI. See the
show here.
January 2008 Public Update
More on Phenomenon, IIG's appearance on KCET's Life and Times, the
Daughter who sees in the dark, an upcoming application change, a new UFO DVD
that features an IIG investigator, and more.
IIG's Recommended Reading
IIG has put together a list of books, suggested by our members, for those wishing to learn more about science, skepticism, human psychology and the paranormal.
Steven Greer Speaks at MUFON OC Meeting
The founder of the Disclosure Project spoke recently at the Orange County MUFON's monthly meeting. IIG's David Richards was there, and
gives a report of what Dr. Greer had to say.
Read the low down on Phenomenon, the Long Island Healer, the Rocky Mountain Mirror Man, a girl who can see in the dark, a MUFON meeting, and more.
November 2007 Public Update
IIG's been keeping busy. Read the latest.
2007 Public Update
Read about our activities in
the month of September.
Gravity Hill Investigation
Our early 2006 investigation of the mysterious Gravity
2007 Public Update
See what we've been up
to in August, from our IIG Awards to an informal demonstration by a man who
claims to heal with quantum touch.
2007/08/17 The First Annual IIG Awards
Watch the full 2006 IIG Awards ceremony. Writers from The Simpsons and Psych were present to receive their awards. Find out who
was placed in the Hall of Honor, and who won for Truly Terrible Television. Also, learn more about the
IIG Awards: why we offer them and how we select the recipients.
Awards Press Release
Announcing the recipients of the first annual IIG Awards.
2007 Public Update
We will now be
publishing monthly updates to keep the public informed about our ongoing
Glen Ivy: A Study in Rational Decision Making
Investigator Wendy Hughes writes an exposé of the Glen
Ivy hot springs spa, separating the realities of relaxation from spiritual
speculation. This story was published in the June 2007 edition of
Skeptical Briefs (newsletter of the Committee for Skeptical Inquiry, our
parent organization). Read the entire article
in PDF
2007/05/06 The $50,000 Paranormal Challenge
It's finally here! See our examination of the psychic Nigel Britman.
Carlon Baron, Psychic Detective? Not quite.
IIG's own Brian Hart wrote an article published in the
Sept/Oct 2006 issue of Skeptical Inquirer, shedding some much-needed light
on the vaunted claims of psychic Carla Baron. Read the entire article
Carla Baron Update from Randi
Check back for more details!
2005/10/25 IIG members interviewed on Audiomartini regarding the Carla Baron Investigation
2005/07/23 Our first official pre-screening test for James Randi
Carla Exposed at the Amaz!ng Meeting! 3 in Sin City!
Sherri Andrews and Brian Hart presented our Carla Baron exposé to a truly international audience at James Randi's Amaz!ng Meeting! 3 in Las Vegas on January 16. This presentation was one of six chosen out of a total of about 30 submitted papers. We even fielded a question from Richard Dawkins himself! We've received nothing but positive feedback on the presentation, and hopefully encouraged others to get involved in investigations in their own hometowns. And in case you missed it, our presentation appears on the Amaz!ng Meeting! 3 DVD... available for purchase on Randi's site.
2004/12 Self-proclaimed psychic detective Carla
You've seen her on Court TV and ABC - now read the facts!


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Written by Angelica
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scent life: 11-15 hours
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Banana Oatmeal Cookies Recipe
- 1 cup butter-flavored shortening
- 1 cup sugar
- 2 Eggland's Best Eggs
- 1 teaspoon vanilla extract
- 2 cups all-purpose flour
- 1 teaspoon baking soda
- 1 teaspoon ground cinnamon
- 1 teaspoon ground cloves
- 3 medium ripe bananas, mashed
- 2 cups quick-cooking oats
- 1 cup (6 ounces) semisweet chocolate chips
- In a large bowl, cream shortening and sugar until light and fluffy. Beat in eggs and vanilla. Combine the flour, baking soda, cinnamon and cloves; add to creamed mixture and mix well. Stir in bananas, oats and chocolate chips.
- Drop by rounded teaspoonfuls onto greased baking sheets. Bake at 375° for 10-12 minutes. Immediately remove cookies to wire racks to cool. Yield: about 4 dozen.
Reviews for Banana Oatmeal Cookies(18)
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Great quick cookie! Absolutely adorable....
I adjusted this one to accommodate the ingredients I had on hand. Instead of a full cup of butter flavored Crisco, I used 1/2 cup each of regular Crisco and butter. Instead of chocolate chips, white chocolate chips went into the batter. Next time, I'll add some walnuts or pecans.
Excellent taste and texture! Cookies are very soft and moist. I would have added more chocolate chips, but my wife thinks that more chocolate would everpower the very pleasant banana taste. Definitely a keeper!
I had to make this with butter because my children are allergic to soy including shortening. These cookies were easy to make with my little ones. They were soft and rounded like pumpkin cookies and yummy. Next time I will substitute half of the butter for applesauce. Oh and I used unsalted butter because I figure butter flavored shortening is unsalted.
Got to agree. Why ruin a healthy cookie with all that trans fat?


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Nearly 500 workers are involved in an operation led by Titan Salvage to remove the wreck while protecting the marine environment.
Titan and Costa Cruises said earlier this month that they hope to be able to rotate the vessel to a vertical position in September. They will then be able to assess whether it can be refloated and towed away.


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The FBI reluctantly enlists Jane's help to find a missing computer programmer, but he won't help unless Lisbon is brought on board as well. (TV-14 L, V) watch
The FBI reluctantly enlists Jane's help to find a missing computer programmer, but he won't help unless Lisbon is brought on board as well. It's a whole new world for Jane…and for the FBI. But will their arrangement actually work? watch
Go behind the scenes Jane's move to the FBI with creator Bruno Heller and Executive Producer Chris Long.
Rome: : -- MovieMaze.de - Trailer (Quicktime)
And then there were seven... CBI criminal consultant and former sham psychic Patrick Jane is closing in on the elusive serial killer Red John - who murdered Jane's family years before. Armed with a list of seven suspects (confirmed by the diabolical killer himself), Jane and the CBI team will narrow down the list in Season Six, while simultaneously solving the state's most serious crimes.
more Bruno Heller Clips & Interviews videos
The FBI reluctantly enlists Jane's help to find a missing computer programmer, but he won't help unless Lisbon is brought on board as well. (TV-14 L, V) Also available on iTunes, Amazon Instant Video and VUDU
Two years after the Red John case was put to rest, Jane's newfound peace is interrupted by a surprising job offer that could change everything for him. Emily Swallow joins the cast as Kim Fischer. (TV-14 L, V) Also available on iTunes, Amazon Instant Video and VUDU
Patrick Jane finally comes face-to-face with Red John, the serial killer he's tracked since the madman murdered his wife and daughter. For 10 years, Jane has doggedly hunted his nemesis in his search for justice. (TV-14 L, V) Also available on iTunes, Amazon Instant Video and VUDU
Following the shocking events at Jane's house, the Red John list is narrowed down further, and the CBI's priority is the remaining suspects. (TV-14 L, V) Also available on iTunes, Amazon Instant Video and VUDU
more Bruno Heller On TV videos
more Bruno Heller credits (7 total credits)
[Warning: The following story contains major spoilers from Sunday's episode of The Mentalist. Read at your own risk.]
Be careful what you wish for. The Mentalist's Patrick Jane finally got his revenge on the man who slaughtered his wife and daughter — the sardonic, William Blake spouting serial killer Red John. But now what? TV Guide Magazine had a chat with Simon Baker, who plays the crime-busting Jane, about where the show and his character will go from here. Will Red John's death really help Jane deal with his grief? Can he move on with his life and maybe even find love again?
So did you figure it out or were you shocked you-know-whatless? After five seasons and change, The Mentalist has finally revealed the identity of serial killer Red John. read more
Patrick Jane isn't the only person who's eager to bring his decade-long hunt for Red John to a close on The Mentalist. Simon Baker says the conclusion of the story line, after Sunday's final showdown, is a relief for him as well.
"This last five, six months that we've been working on the show, it's been really exciting for me," Baker said on a conference call this week. "It's felt like I've had the sort of enthusiasm that I had in the first season because it's new and fresh from week to week and it's going somewhere. Sometimes the frustration for me as an actor is that we're not going anywhere, not moving forward. In this, we're definitely going somewhere, and the stakes are high and it gives me something to do that I can really get my teeth into."
[Warning: The following article contains spoilers from Sunday's episode ofThe Mentalist. Read at your own risk!]
After five seasons of on-and-off romantic tension on The Mentalist, Wayne Rigsby (Owain Yeoman) and Grace Van Pelt (Amanda Righetti) finally tied the knot on Sunday's episode, after being inspired by another couple's wedding. (Fortunately, Rigsby and Van Pelt's nuptials weren't marred by the murder of a family member the night before, however.)
"It's been fun exploring the relationship," executive producer Daniel Cerone tells TVGuide.com. "From the beginning [creator Bruno Heller] had a plan for the show to run many years, and we didn't want to get them together permanently too soon, because we wanted to sort of play all the drama that exists in real relationships, in terms of missteps and mistakes and failures and fears. And we feel like we've really mined that over the years, and mined it honestly."
So what finally made them take the plunge, and how long will the newlyweds' honeymoon period last? Check out our full interview with Cerone to get answers to those burning questions and more:
It's the beginning of the end for the Red John story line on CBS' The Mentalist. Creator Bruno Heller has promised that the case which has plagued Patrick Jane (Simon Baker) since Season 1 will be solved this year. And based on the Season 6 premiere, Heller and Co. aren't wasting any time in getting to the conclusion.
"We've never really started a season with this kind of situation in which our guys are very, very close to the bad guy, but the bad guy knows exactly as much as they do," Heller tells TVGuide.com. "It's an interesting chess position that they're both in as we start. ... In this first episode, Lisbon is dealing with the fact that Jane for the first time doesn't seem to know what to do next. And that scares the hell out of her."
We asked Heller to make a case for each of the seven suspects. "All of those guys have reasons to hide aspects of their personality," he says. "It's just a question of whether they're hiding for ordinary prosaic reasons or for sinister, evil reasons."
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Title: | A legjobb weboldalak egy helyen |
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Website Worth: | $917 USD |
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Server Location: | Hungary |
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An Accountability Framework for Financial Statement Auditors and Related Research QuestionsMark E. PeecherUniversity of Illinois at Urbana-Champaign; University of Illinois College of Law Ira SolomonUniversity of Illinois at Urbana-Champaign Ken TrotmanUniversity of New South Wales (UNSW) - School of Accounting July 15, 2013 Peecher, M. E., et al. An accountability framework for financial statement auditors and related research questions. Accounting, Organizations and Society (2013) Abstract: We address the following overarching questions: What kind of accountability framework could regulators use to (a) motivate auditors to improve audit quality, and (b) evaluate how well auditors have carried out their duties? We draw on research in accounting, economics, psychology, and neuroscience to critique the accountabilities, incentives, and learning opportunities embedded in auditors' extant regulatory environment. We first establish that forward-looking estimates are the basis for most financial statement information and that some of these estimates are highly uncertain, which increases the challenges faced by auditors. We propose an accountability framework with two dimensions: rewards versus penalties and processes versus outcomes. We show that auditors' current regulatory accountabilities generally are in the form of penalties rather than rewards and primarily depend on audit outcomes rather than attributes of auditors' judgment processes. We provide evidence from a range of disciplines that questions the suitability of the present system for improving the quality of auditors' judgments and the quality of evaluations of those judgments made by inspectors. We identify four potential changes for improvement in audit quality based on our framework. Each of these identified changes has an impact on one or both of the two dimensions in our framework. For each of these changes, we outline JDM research questions that could be addressed to inform our overarching questions and to provide empirical evidence to help refine our accountability framework and improve audit quality. Keywords: Professional judgment, professional skepticism, inspections, audit quality, accountability JEL Classification: M41 Accepted Paper SeriesDate posted: October 16, 2010 ; Last revised: September 4, 2013Suggested CitationContact Information
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Charles LaMonica
Senior Vice President
Corporate and Educational Dining
Restaurant Associates
Hometown: Masontown, Pa.
Education: B.S. in economics, University of Pennsylvania; culinary degree from CIA
First full-time job: Greenskeeper for a nine-hole golf course in western Pennsylvania
Married, two daughters
Charles LaMonica has what one might call a healthy obsession with cycling. His bicycle has taken him all over the country, while taking his mind far from the cares of the workaday world of contract foodservice. For the past six years, he's even used his bicycle for a noble cause, to raise money for teens in crisis.
"Cycling is my form of golf. I've been cycling since college and have always done it as a pastime and a passion. When I started cycling it was a way to get around the city of Philadelphia. Philadelphia is a bike-friendly city, so it was a way to get some exercise and to get around as a college student at the University of Pennsylvania. Later, when I was a chef at the Breakers in Florida, I used to cycle to work every day, and I still cycle most days from my home to the train station in Princeton. So I've always taken that with me. It's really become about exercise, about unwinding. It's a tonic for the stress of our fast-paced business. I've always integrated cycling into my lifestyle.
In recent years, through my involvement with Anchor House, I have become much more dedicated to cycling.
Anchor House is shelter for runaway, homeless and abused teenagers. It is based in Trenton, N.J., and serves the greater Mercer County area. I learned about the organization through my church. They would come to Mass to try to raise funds. I heard these guys talking about these arduous rides of 500 miles in 7 days, and they talked about the cause they were riding for and I was intrigued by it. Riding 500 miles in seven days sounded like a lot of fun. It took me a couple of years to organize my schedule so I could do it, but six years ago I signed up for it and I've been doing it ever since.
The starting point for the road changes every year, but we always end up at the Quakerbridge Mall in Lawrenceville, N.J. Funds are raised through pledges. Every rider is required to raise a minimum of $750. The average rider raises $3,000, and last year we raised over half a million dollars. This year the ride starts in Harrisonburg, VA. It goes up the Blue Ridge to Front Royal, Va., then up through Hagerstown, Westminster and Aberdeen, Md., and through Lancaster, Pa.
I take my bike with me everywhere. I found the Cape Breton highlands up in Nova Scotia particularly spectacular. The roads there at the intersection of the mountains and the coast are incredible. There is wonderful wildlife and vistas that take your breath away—and hills, which always add to the fun.
The Olympic Peninsula is great cycling, and the coast of California is like cycling Nirvana, along the PCH going up from Santa Monica or down from the Monterey Peninsula. In general, the mountains and oceans combination makes for wonderful cycling.
I do some of my best thinking and reflection on the bicycle. You have a time when you are unfettered by any outside disturbances, and you can reflect on what's going on and come up with game plans and resolutions to issues. It's really the time I have the most clarity of mind."


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WASHINGTON—Teetering on the edge of the fiscal cliff, lawmakers from both parties seemed reasonably optimistic Sunday that a deal was in the works that would at least spare Americans an across-the-board tax hike.
As Senate leaders negotiated behind closed doors, rank-and-file members fanned out on the TV talk shows to field the inevitable question: Are we going over the cliff or not?
Sen. Chuck Schumer (D., N.Y.) , appearing on ABC's "This Week with George Stephanopoulos" said, "there's a real possibility of a deal."
"I've been a legislator for 37 years and I've watched how these things work," Mr. Schumer said. "On these big, big agreements, they almost always happen at the last minute."
Should the talks collapse, the nation would be hit with a mix of tax increases and spending cuts that could trigger a recession. Lawmakers interviewed said they were confident the two chambers would work out a compromise that would spare most Americans a take hike, even if a more ambitious deficit-reduction package seemed out of reach before the new year.
Asked about the prospects for a smaller-scale accord, Sen. Lindsey Graham (R., S.C.) said the odds were "exceedingly good."
"I think people don't want to go over the cliff if we can avoid it," Mr. Graham said on "Fox News Sunday."
Sen. Dianne Feinstein (D., Calif.), appearing on the same program, said, "I think the leadership now is working. It will probably be an immediate deal. In other words, it's not going to solve all of the problems forever. But it's going to solve certain problems."
Appearing on CNN, Sen. Bob Corker (R., Tenn.) said: "I would bet my life that over the next very short period of time, 98% to 99% of the people in the country are going to be rescued" from a possible tax hike.
One person who seemed more guarded was the president. Barack Obama had taped an appearance Saturday on NBC's "Meet the Press." First question out of the box from host David Gregory: "Are we going over the fiscal cliff?"
"Well, I think we're going to find out in the next 48 hours what Congress decides to do…" Mr. Obama said.
Related: WSJ's David Wessel explains the contentious debate over how much wealthier Americans should contribute in taxes.


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ASUS, world-leading producer of top quality graphic solutions, has today introduced the ASUS EAH4890 Series—the world's first graphics cards to utilize Voltage Tweak technology. With this innovation, users will be able to boost GPU voltages via the SmartDoctor application and enjoy up to an amazing 15% in performance improvement. For users who are looking for a graphics card offering astounding graphical performances even on default settings, the ASUS EAH4890 TOP will enable an 8% performance boost, delivering exhilarating gaming experiences. Up to 15% Performance Boosts with Voltage Tweak Technology Equipped with the Voltage Tweak technology and SmartDoctor application, the ASUS EAH4890/HTDI/1GD5 raises GPU voltages from 1.312V to 1.4V, allowing GPU and memory clock performances to be boosted from 850MHz to 950MHz and 3900MHz to 4600MHz respectively. Such unprecedented performance upgrades help raise the EAH4890's 3DMark Vantage Extreme Preset score from 4612 to 5300—an unbelievable 15% speed improvement when compared to any other reference designed board*. Gamers can now feel the adrenaline rush afforded by true-to-life graphics performance, only with the ASUS EAH4890 Series. Enjoy 108% Performances under Default Setting The EAH4890 TOP offers a guaranteed increase of its GPU and memory clock performances from 850MHz up to 900MHz and 3900MHz up to 4000MHz respectively. With such extraordinary performance increases, the EAH4890 TOP's 3DMark Vantage Extreme Preset score is raised from 4612 to 4980—an astonishing 8% improvement in speed when compared to any other reference designed board*. This default 8% improvement is the perfect platform for gamers looking for extreme gaming performance right out of the box. So get ready to feel the adrenaline rush of gaming like never before—only with the ASUS EAH4890 TOP! SmartDoctor for the Most Powerful Overclockability ASUS garners yet another world's first with the ASUS SmartDoctor—an overclocking utility capable of tweaking the GPU voltage on the EAH4890 Series. Now, with just a mere few clicks, the ASUS SmartDoctor will deliver astounding voltage boosts and performance upgrades—all without the hassles of re-flashing the BIOS at the risk of damaging the cards, or groping blindly for a overclocking button at the back of the chassis. ATI Stream Technology The EAH4890 Series also incorporates the ATI Stream technology, which utilizes the massive parallel processing power of AMD graphics processors to deliver new capabilities that go beyond the traditional usage scenarios of graphics rendering and video processing. This enables better balanced platforms capable of running demanding computing tasks faster than ever. Along with leading third-party industry partners and academic institutions worldwide, AMD is building a complete ATI Stream computing ecosystem, one that delivers the performance, applications, software and tools necessary to turn AMD's low-cost application acceleration vision into reality. Note: * Performance Configuration PCI-Express 16X: MB: MaximusExtreme Rev:2.00 BIOS: 0802 CPU: Intel Core 2 Extreme 3.00GHz (QX9650) Memory: 2048MB (DDR3 APACER 1333 1024M * 2) HDD: WD SATAII 300 1600AAJS DVD-ROM: LG DVD-GSA-H55N - Overclocking capabilities may vary when using different cards - The 3DMark Vantage score was obtained using Extreme Preset Source: ASUS
I wonder if that software can work with 4870's.. I will DL it later and get my 4870 to 850mhz if I can. Right now I can only do 775 stable..
SmartDoc is 30 days trial for non-Asus cards I think, free for Asus videocards. As a user with a HD 4850 I don't recommend installing it. It has many problems... I wish that AMD would have released HD 4890 already OC so it would have the single GPU crown, not like this, being kicked so brutally by GTX 275 in almost all benchies.
I was just reading a review on the Asus, the voltage tweaking can actually take it to 1.45v! Very nice.
I may give this a try on my 1GB card. Although, I wish they would implement their 3 step Overvoltage protection like they do on their GTX275 cards.
If I am correct 4850's are missing the component that would allow voltage control, so using this on a 4850 would cause issues where as a 4870 might not. And there is 2 options for buying 4890's OC'd... Anything I seen the 4890 puts up a good fight with the 275.
" AMD has put two VT1165 voltage controllers on their cards. One is responsible for the VGPU core voltage and the second one controls the memory voltage. This is very nice for overclockers because they can now change both voltages via software. For the average joe, it is a production cost increase that seems quite unnecessary." http://www.techpowerup.com/reviews/Sapphire/HD_4890/ w1zz's review
You are correct. The Asus software won't work on any HD4850s and a majority of the recent HD4870 1GBs out there now. It would still be limited to reference PCB design HD4870s with the Volterra VRM controller...
Look back at what I said, a guy earlier mentioned it didn't work well on his 4850 and thats what I was talking about.


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Lost and Found Again: Photos of African-Americans on the Plains
What would otherwise be a local-interest story became a snapshot of history integral to the American experience
- By Joseph Stromberg
- Smithsonian magazine, February 2013, Subscribe
Douglas Keister has spent the past four decades traveling the country to photograph subjects as varied as architecture, folk art and cemeteries. Over the years, as he moved from his hometown of Lincoln, Nebraska, to several different cities in California, he carted around a heavy box of 280 antique glass-plate negatives that he'd bought when he was 17 from a friend who'd found them at a garage sale. "I thought, 'Why the heck am I keeping these things?'" he says.
Then, in 1999, Keister's mother sent him an article she'd seen in the Lincoln Journal Star saying historians in Lincoln had unearthed a few dozen glass negatives that featured portraits of the city's small African-American population from the 1910s and '20s, an era from which few other photos survived. Keister compared the images with his negatives, and "I just thought, 'Wow,'" he says. "The style of the pictures, the backdrops used—they looked the exact same." Almost by accident, he realized, he had conserved a rare glimpse into the everyday lives of an African-American community on the Great Plains.
Now Keister, who is 64 and lives in Chico, California, is donating 60 large-scale prints made from his collection for display in a permanent home—the National Museum of African American History and Culture, under construction and due to open on the National Mall in 2015. "They speak to a time and a place where African-Americans were treated as second-class citizens but lived their lives with dignity," says curator Michèle Gates Moresi. "You can read about it and hear people talk about it, but to actually see the images is something entirely different."
Determining exactly who those people were—and what skilled hand took their photographs—has taken significant detective work. After Keister read the Journal Star article, he took his negatives back to Lincoln and showed them to local historian Ed Zimmer, who was surprised to see how many there were. Together, they set out to identify the mystery photographer. "We took some wrong turns," Zimmer says, but their search led them to a 94-year-old Lincolnite named Ruth Folley. "She went and got her box of family photos, and one of them matched ours, and she just said, 'Well, Mr. Johnny Johnson took all of these.'" Her assertion was confirmed when Zimmer turned up a vintage print with a signature in the corner: John Johnson.
Through census records, Zimmer discovered that Johnson was born in Lincoln in 1879 to Harrison Johnson, an escaped slave and Civil War veteran, and his wife, Margaret. After graduating from high school and briefly attending the University of Nebraska (where he played football), Johnson found work in one of the few realms open to African-Americans at the time: manual labor. "He was a janitor and a drayman," says Zimmer, "but also a very prolific and talented community photographer." From roughly 1910 to 1925, he took as many as 500 photographs using a bulky view camera and flash powder. Some appear to have been commissioned portraits, while others feature co-workers, family and friends, and yet others convey Johnson's personal interests—construction sites and local architecture.
As they scrutinized the portraits, Keister and Zimmer began to see something else emerge: an untold story of what historians call the new negro movement. Following World War I, African-American writers, musicians, artists and academics across the country sought to promote confidence, dignity and self-expression—a movement that would blossom into the Harlem Renaissance. Johnson's portraits, they realized, were part of the same intellectual current. His subjects were formally posed and dressed in their best, and they often held books to show that they were educated. "Up until then, many photos of African-Americans showed the plight of the poor," Keister says. "These photos are elevating. They're ennobling."
Subscribe now for more of Smithsonian's coverage on history, science and nature.
Related topics: Photography Black History American Great Plains
Comments (7) |
You remember the musical culture in Jacksonville Florida well I my friend found a poster an d it's a swing band poster lol not kidding I'm in one of the most historical part of north eastern Florida on a island the name I'm not saying but it shows a kid maybe about 12 or 13 ,and trust me it's not Michael Jackson way before that time.Quiz might be a veryimportant document.
Posted by Clint Armstrong on May 1,2013 | 07:27 PM
Thanks, Mom Don't you just love it when Moms send published article clippings to their adult children about things that might interest them? Photographer, Douglas Keister's mother did just that, and it resulted in an amazing snowball effect of brilliant discoveries, plus a major exhibition in a national museum. Thank you, Mrs. Keister. I would hope that President Obama or the First Lady have acknowledged you and will congratulate you with your son at the exhibition's opening reception. Emily Benjamin New Jersey
Posted by Emily Benjamin on March 13,2013 | 05:31 AM
Would it be possible to see more of these photos? My mother was born in Lincoln, Nebraska in 1918, during the period covered by these photographs. She and her family lived in Lincoln for at least 12 more years. Neither she or my grandparents ever talked to me about other African-American families. I never realized that they were part of an African-American community.
Posted by James S. Peters on February 20,2013 | 11:49 AM
I have a lot of glass negatives: https://picasaweb.google.com/114431897981658921755/GlassNegativeScans4x5Album6 https://picasaweb.google.com/114431897981658921755/GlassNegativeScans5x7Album7 https://picasaweb.google.com/114431897981658921755/GlassNegativeScans4x5Album5 Here are just a few of what I have.
Posted by Lloyd Smith on February 3,2013 | 11:27 PM
AMAZING find! Thank you! Can not wait to share this information in my class on African American Traditions (see blog: http://aatraditions.blogspot.com/).... You just keep proving WHY I love Smithsonian so much - my magazine subscription, this on-line version, and of course the venues when I am able to travel to DC. ...Love Love Love Smithsonian, and cannot wait for the new Museum of African American History and Culture to open next year!
Posted by Rosalind Nichol on January 31,2013 | 10:20 AM
Simply extraordinary, I found a smaller cache under similar circumstances, 1916 glass plate negatives of the Provincetown, Massachusetts art colony. I donated them to the Archives of American Art at the Smithsonian. Treasures like this, almost lost and found again are endlessly fascinating.
Posted by Stephen Borkowski on January 29,2013 | 08:10 PM
Thank you,Smithsonian.
Posted by Paula E. Boothe on January 26,2013 | 03:06 PM