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The executive overseeing Advanced Micro Devices Inc.'s (AMD) relationship with videogame-console makers has left the company to join rival NVIDIA, taking with him years of experience in the competitive field. Bob Feldstein, who joined AMD when the company acquired graphics-chip maker ATI in 2006, has taken on the role of vice president of technology licensing at NVIDIA. He most recently served as AMD's corporate vice president of business development and also led the company's Boston Design Center, which focuses on design engineering for AMD's various chips. Source: The Wall Street Journal
Maybe this guy will be the main contact person for smaller console projects like Ouya (since it uses a Tegra 3).
That's a non-compete disclosure and is tied to a term contract. Not all term contracts have them. If his didn't then shame on AMD's legal team. That's an epic screw up. Personally I have never signed one. I won't work for a company that plays those games unless there is a massive severance tied to it.
Those non-competes are impossible to actually enforce. The more ridiculous they are, in number of years, the less they hold up in court.
well when you work for large corporations like AMD/Intel/nVidia you would kind of expect them to have non-compete clauses for this reason here. I has valuable information as to what rival (AMD) company is working on. I shared the information and not the actually technology and rival (nVidia) now knows what to expect so the can develop new technology to surpass rival (AMD). If the large corporations were to average out their R&D development times from start to finish and then take that time and write it into their non-compete clauses that would be a smart move from a business legal point of view. The worker can share information as long as it isn't exact data without sharing trade secrets So say I worked for AMD and nVidia hired me (before eyefinity) I sould have shared information on how AMD planned on creating a program that would allow players to play on multi-screens in panoramic view. nVidia might have pushed TONS of money to do the same thing and as long as I didn't give information on how they planned to complete this is would have been perfectly legal. And if the nondisclosure clause could be proven to be a reletivly responsible time frame then the company could sue both the ex-employee as well as the rival company in case of sharring project ideas. But that's just my $0.02
Already been announced the major consoles will be using AMD only next gen.... so yeah, all the best to him, he is missing out on a nice pay raise Winter 2013/14.
I guess he actually wants to work with a company that he thinks has a better future than the company he left. He knows better than any of us what's inside AMD. Actually I'm quite surprised he was allowed to make this move so smoothly.
Nvidia could hire him even with a "*Non-Compete Clause" and just pay the hefty fine to AMD. HP and other computer giants have done it aswell while recruiting talent. You mean that after doing his job in securing Console contracts. What else is he gonna do but just collect a pay check at AMD for the next 3-4years until it comes times for Consoles to refresh. By that time we could be looking at a whole new landscape. Nvidia is try'n to break into the mobile market and smart-tv. They will probably use him to sweet talk Samsung and others into exclusively carring their internals or proprietary link systems. in the US nvidia for all its efforts in mobile tegra it only has one phone to show for it and currently testing 3 in Europe and the reviews arent great compared to the competition.
Google Nexus 7 and Microsoft Surface use Tegra 3. Countless Chinese OEMs use Tegra in cheaper phones. I think NV put its foot clearly in this market in a short time. In the meantime last week: When AMD VP Rory Read spoke during conference call he pointed out that AMD for the first time since 2001 has seen a dropping interest three quarters in a row for PCs. The actual report revealed a revenue that was down 10 percent year-to-year and landed at 1.41 billion dollar. AMD made a profit of 77 million dollar, up from a loss of 580 million dollar last quarter, but it is the future for the company and PCs overall that worries the most. "For the first time since 2001, client PC shipments have declined sequentially for three consecutive quarters-and have been below historical averages for the last seven quarters.[...]We also believe the PC industry may be resetting to a new [lower] baseline," - Rory Read Also: Advanced Micro Devices Inc.'s shares plunged Friday to their lowest level in more than three years after the chipmaker reported that economic weakness dragged down its second-quarter results and would hurt its performance through the summer. THE SPARK: AMD announced Thursday that its second-quarter net income fell 40 percent on overall weakness in the global economy, softer consumer spending and lower demand for its processors overseas. While the company said it is taking steps to improve its performance, it expects "headwinds" to continue to challenge the company into the third quarter. So, tough times ahead and as much as I hate tablets and everything mobile this is where we are heading.
By the way things are looking for AMD I wouldn't be surprised if the World ends up with Intel nVidia having monopoly. Would be a sad day. Damn you AMD why did you ave to make the Bulldozer chips have the speed of a bulldozer
Arun Iyengar -> is the new game console guy http://www.amd.com/us/press-releases/Pages/amd-strengthens-commitment-2012jun11.aspx Jim Farrell -> is the new design guy http://www.linkedin.com/pub/jim-farrell/10/a7a/a89 AMD -> Sony -> Military deal maybe to replace the Sony PS3 clustercomputer ^--
Agreed, however, it's in the interest of the gaming community (myself included) that AMD and Nvidia both thrive because without serious competition we will end up with a Microsoft-esque type mentality in the video card market where we are told what we will be using, despite our objections, and we will pay whatever price they think they can gouge us for and go throw yourself off a friggin' cliff if you don't like it kind of attitude.


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subset: commoncrawl


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Places Discussed (Cyclopedia of Literary Places)
*London. Great Britain's capital city, a place cloaked in brown fog, is populated by people who walk in circles without connection to anything or anyone. The walk from London Bridge down King William Street leads past a church to the financial district, which for Eliot represents spiritual and cultural emptiness. Although the street, named after William the Conqueror, the first king of England, and the church carry important names in England's rich history and religious experience, the citizens take no note of them. Other scenes convey this spiritual emptiness: a tawdry sexual encounter between a clerk and a secretary in her shabby apartment and a conversation in a saloon involving an anxious pregnant woman concerned about how to deal with a pregnancy by another man now that her lover is returning from a tour of duty in the army.
*London Bridge
*London Bridge. Historic bridge over the River Thames; a transcendental symbol of all that is good and promising in contemporary life, London Bridge leads to the city of the dead, to the loss of possibility and meaningful spiritual life.
*River Thames
*River Thames tehmz). England's greatest river symbolizes a more romantic and joyful past and, in its present polluted condition, the spiritual emptiness of modern life. An elaboration of this symbolism comes in the reference to the Leman, the Swiss name for Lake Geneva, where Eliot was...
(The entire section is 325 words.)
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Historical Context
World War I
While Eliot published The Waste Land in 1922, it was widely acknowledged as reflecting the disillusionment in Europe following World War I. This global war started from a regional tragedy. On June 28, 1914, Archduke Franz Ferdinand, heir to the Austro-Hungarian throne, made a fateful trip to Sarajevo, capital city of Bosnia and Herzegovina— two provinces under his family's control—where he and his wife were assassinated. These murders reflected a regional tension among some residents of the two provinces, which wished to become part of Serbia once again. Serbia, which also wished to reclaim Bosnia and Herzegovina, helped stage the assassinations.
When this fact was realized by Austria-Hungary, the leaders of this nation state declared war on Serbia on July 28, exactly one month after the assassination. In times past this might have been a localized battle between two countries. But due to an extensive system of pre-existing alliances, most other European countries were pulled into the war, which escalated the conflict. Eventually the list of combatants grew to include the United States and parts of Asia, all of which aligned themselves with either the pro-Serbian "Allies" or with the "Central" powers, who supported Austria-Hungary.
When fighting began in August 1914, each side believed its modern weapon technologies such as hand grenades, tanks, long-range artillery, and poison gas would lead to a...
(The entire section is 506 words.)
Literary Style
The most important aspect of the work, and the one that informs all others, is the literary movement to which it belongs, modernism, which this work helped define. Modernism is the broad term used to describe post–World War I literature that employs techniques Eliot uses in The Waste Land. These techniques, and all the techniques associated with modernist literature, expressed a rebellion against traditional literature, which was noted by its distinct forms and rules. For example, in traditional poetry, poets often sought uniformity in stanza length and meter. Those poets who could work within these sometimes challenging rules and still express themselves in a unique or moving way were considered good poets. But particularly after World War I, as literature and other art shifted from a traditional, romantic, or idealized, approach to an approach that emphasized gritty realism full of discontinuity and despair, artists began to experiment with nontraditional forms, ideas, and styles.
Disillusioned by the war, artists and writers such as Eliot rebelled against the logical, traditional thinking—which they believed helped start and escalate the war. Eliot's poem, in all of its complexity and obscurity, was like a catalog of modernist poetic techniques, including free verse, odd stanza lengths, snatches of dialogue, quotations from other works, phrases from other languages, indistinct transitions, conflicting ideologies such...
(The entire section is 266 words.)
Topics for Further Study
Find a painting, movie, or other visual artwork you think could serve as a companion piece to the poem. Explain why you think this pairing makes sense.
Research what life was like for soldiers during World War I. Imagine that you are a soldier in the trenches along the Western Front. Write a journal entry that describes your typical day.
Imagine that through time travel Eliot is able to visit your town for one day and that you have been assigned to give the poet a tour. Based on what you know of Eliot and what you know about your own society, write a story that describes Eliot's reactions to modern life.
Read another work by a different author who became disillusioned by World War I. Compare this work to Eliot's The Waste Land.
(The entire section is 136 words.)
Media Adaptations
Eliot's The Waste Land and several other works were adapted as an unabridged audiobook in 2000, featuring narration by the author. T. S. Eliot Reads: The Waste Land, Four Quartets, and Other Poems is available from HarperAudio.
(The entire section is 37 words.)
What Do I Read Next?
Many critics highlight the fact that Eliot wrote The Waste Land while he was suffering a nervous breakdown. Another group of post–World War I writers disillusioned by the war, the surrealists, attempted to create literary works while their minds were in alternative states, a condition often reached by deliberate attempts to affect their consciousness, such as through hypnosis. The Magnetic Fields (1920), a series of prose poems by French poets André Breton and Phillipe Soupault, was created during one of these mental experiments, a marathon project that lasted eight days.
Eliot's "The Love Song of J. Alfred Prufrock," first published in the magazine Poetry (1915) and later collected in Prufrock, and Other Observations (1917), is considered one of Eliot's most important works. Like The Waste Land, the poem mixes classical references with other modern images. The poem details the ramblings of the title character, a self-doubting man who is pessimistic about his future and the future of society.
In 1971, Eliot's estate authorized the release of a facsimile edition of the poet's original 800- line version of the poem, entitled, The Waste Land: A Facsimile of the Original Drafts, Including the Annotations of Ezra Pound. As the title implies, the book includes the original revision notes from Pound, but it also includes notes from Eliot's first wife and Eliot himself. This landmark edition,...
(The entire section is 526 words.)
Bibliography and Further Reading
Aiken, Conrad, "An Anatomy of Melancholy," in New Republic, Vol. 33, No. 427, February 7, 1923, pp. 294–95.
Brooker, Jewel Spears, "T. S. Eliot," in Dictionary of Literary Biography, Vol. 45: American Poets, 1880–1945, First Series, edited by Peter Quartermain, Gale Research, 1986, pp. 150–81.
Cooper, John Xiros, T. S. Eliot and the Politics of Voice: The Argument of "The Waste Land," UMI Research Press, 1987.
Eliot, T. S., The Waste Land, in The Waste Land and Other Poems, edited by Frank Kermode, Penguin Books, 1998, pp. 53–69.
Ellmann, Richard, "The First Waste Land-I," in New York Review of Books, Vol. 17, No. 8, November 8, 1971, pp. 10, 12, 14–16.
Hargrove, Nancy Duvall, "T. S. Eliot," in Dictionary of Literary Biography, Vol. 7: Twentieth-Century American Dramatists, edited by John MacNicholas, Gale Research, 1981, pp. 151–72.
Torrens, James S., "T. S. Eliot: 75 Years of 'The Waste Land,' " in America, Vol. 177, October 25, 1997, pp. 24–27.
Vendler, Helen, "T. S. Eliot," in Time, Vol. 151, No. 22, June 8, 1998, p. 108.
Further Reading
Bloom, Harold, ed., T. S. Eliot's The Waste Land (Modern Critical Interpretations), Chelsea House Publishers, 1986. Bloom collects criticism on The Waste Land from...
(The entire section is 449 words.)
Bibliography (Cyclopedia of Literary Places)
Bergonzi, Bernard. "Allusion in The Waste Land." Essays in Criticism 20, no. 3 (July, 1970): 382-385. An important analysis of Eliot's use of both high and low allusions in the poem.
Brooks, Cleanth, Jr. "The Waste Land: An Analysis." Southern Review 3, no. 1 (1937-1938): 106-136. An influential New Critical reading of the poem that draws out the complexities and the ironic structure.
Canary, Robert H. T. S. Eliot: The Poet and His Critics. Chicago: American Library Association, 1982. A thorough bibliography on the poet and his works and a series of bibliographical essays that discuss various critics who have dealt with Eliot's criticism and poetry.
Frye, Northrop. T. S. Eliot. New York: Grove Press, 1963. An analysis of Eliot's works primarily the critical perspective of myth. Excellent conclusions on the archetypal aspects of The Waste Land.
Kenner, Hugh, ed. T. S. Eliot: A Collection of Critical Essays. Englewood Cliffs, N.J: Prentice-Hall, 1962. A useful collection of essays, part of the Twentieth Century Views series. Contains a number of important essays, including three on The Waste Land.
Williamson, George. A Reader's Guide to T. S. Eliot. New York: Noonday Press, 1953. A close...
(The entire section is 208 words.)
Source: Poetry for Students, ©2013 Gale Cengage. All Rights Reserved. Full copyright.
Source: Cyclopedia of Literary Places, ©2003 Salem Press, Inc.. All Rights Reserved.


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Be one of our 10,000+ subscribers
Gary Johnson
Register before 28 March 2014 and save € 300 on the May session. |
1 |
You will learn techniques and approaches that have been proven to work best for forecasting sales of pharmaceuticals – including pharma-specific drivers like market access, step-care, targeted therapies etc. | |
2 |
You will be able to challenge the forecasts others have produced for you, and produce your own forecasts in most situations. | |
3 |
Concepts will be explained in simple, non-mathematical terms. Concrete examples from the pharma industry are used rather than vague concepts. | |
4 |
You will leave with a collection of techniques and principles that you can implement easily and immediately after the course. | |
5 |
You will receive an Excel-based forecasting tool that integrates all the techniques taught and applied during the workshop. This ensures you leave with real hands-on ability to use the techniques. | |
6 |
You will receive Gary's book Sales Forecasting for Pharmaceuticals: An Evidence Based Approach, which will be a valuable reference to have with you. |
Gary Johnson is an award-winning expert-trainer who:Unlike other forecasting courses, in this programme:
- Has consulted/forecast for every top 10 pharma company.
- Expert in forecasting – but also all quantitative techniques, so that forecasting is tied in to market access, market research etc.
- Has forecast for every leading country and major therapy area.
- Finalist for the MCA Business Book of the Year Award and semi-finalist for the the Financial Times Global Business Book of the Year Award.
- Winner of the EphMRA and the BHBIA (British Healthcare Business Intelligence Association) best paper awards.
- Trained over 1000 executives around the world. His presentations are constantly tweaked according to delegate feedback. They have thus evolved over the years so they are easy to understand and consistently get very high customer feedback scores.
- The focus is on techniques and approaches that have been proven to work best.
- Concepts are explained in simple, non-mathematical terms.
- Concrete examples are used rather than vague concepts.
- Pharma-specific techniques which take into account issues like market-access and not generic forecasting techniques that struggle when applied to pharma.
- Delegates leave with a collection of techniques and principles that they can implement easily and immediately.
- Forecasters who want to build more evidence based approaches into their forecasts.
- Marketers who want to understand how to link forecasts to their real-world concerns (like the competitiveness of their product profile, promotional spend, speed to market etc.).
- Market researchers who want to know how to take data from surveys and audits and reflect them in forecasts.
- Market access and pricing executives who want to break down the silos that exist between forecasting and other functions and to understand how their concerns should be reflected in forecasts
- As well as any other executive who has to produce or receive a forecast as a part of their professional role.
Executives from professional services organizations should request approval from Gary Johnson prior to registering to this course.
Please contact Annelies Swaan, Sales Manager, email@example.com, tel +32 (0)2 709 01 42.
Below is a non-exhaustive list of executives who participated in The Pharma Forecasting Course:
Business Development Manager ALK-Abello Denmark testimonial Sales Analyst Alexion Pharmaceuticals Switzerland testimonial New Products Manager Almirall Spain Business Planning & Analysis Manager Amgen Netherlands Associate Brand Director Astellas UK testimonial Senior Manager Sales Administration Astellas UK testimonial Business Analyst AstraZeneca Romania Head of Supply Chain Bayer Schering France Business Intelligence Manager Boehringer Ingelheim UK testimonial Customer Value Management Associate Boehringer Ingelheim Australia testimonial Busines Analysis Manager Boehringer Ingelheim Austria International Product Manager Boehringer Ingelheim Germany Senior Manager Market Research EMEA Bristol-Myers Squibb France testimonial Commercial Assessment Manager - Corporate Marketing Chiesi Italy testimonial International Brand Manager Chiesi Italy testimonial New Product Advisor Chiesi Italy testimonial Business Development Manager Egis Poland Business Analyst Genzyme The Netherlands testimonial Business Intelligence Manager Grünenthal Belgium Product Manager Grünenthal Germany testimonial Marketing Manager Helsinn Healthcare Switzerland testimonial Global Portfolio Manager Intendis Germany testimonial Business Analyst Ipsen The Netherlands testimonial VP, Licensing & New Business Development Johnson & Johnson Belgium testimonial Marketing Information Manager Kowa UK Analysis & Forecasting Manager LEO Pharma Denmark testimonial Portfolio and Pricing Manager LEO Pharma Denmark testimonial Business Analyst LundBeck Greece testimonial Marketing Manager Medis Slovenia Associate Marketing Director Merck Serono Switzerland testimonial Associate Manager Business Intelligence Merck Serono Switzerland testimonial Business Intelligence Manager Merck Sharp & Dohme Belgium testimonial Project Lead Forecasting Novartis India testimonial Senior Business Analyst Novo Nordisk Netherlands Business Controlling Manager Nycomed Poland testimonial Business Development Analyst Nycomed Russia testimonial Product Manager Organon Sweden Business Development Associate Paion Germany testimonial Head of Business Development & Licensing Department Palau Pharma Spain Key Account Manager Pfizer Turkiye testimonial Pricing & Portfolio Commercialisation Manager Pfizer UK testimonial Manager Business Development Recardio Austria testimonial Market Research Manager Roche Germany testimonial Business Development Director Roche Switzerland Supply Chain and Launch Manager Sandoz Romania testimonial Director Business Support & OTC Sanofi-aventis Belgium testimonial Director Strategic Market Intelligence Sanofi Germany testimonial Sales Analytics & Reporting Analyst Shire UK testimonial Director International Sales and Marketing Training Shire UK testimonial Sales Force Effectiveness Director Solvay Germany Brand Director Takeda United Kingdom testimonial Marketing Manager Takeda UK testimonial Strategic Marketing Director Takeda UK testimonial Supply & Demand Continuous Improvement Specialist Teva Spain testimonial Brand Manager UCB Netherlands testimonial Global Patient & Market Insight Associate Manager UCB Belgium Director New Product Commercialisation CNS UCB Belgium testimonial Director New Product Planning CNS UCB Belgium testimonial Head of Data Strategy and Reporting, Strategic Marketing Practice UCB Belgium testimonial Business Development Uriach Spain Business Development & Project Manager Vifor Pharma Switzerland testimonial National Project Manager Wyeth Netherlands testimonial
The course starts on day 1 at 09:30h with a welcome coffee and ends on day 2 at 16:00h.
Day 1
Welcome & General Introduction
The Right Approach to Forecasting
- When to use models and when to use judgement.
- When to use extrapolation and when to use 'causal' (e.g. promotional spend).
- Whether to use a single forecasting model or more than one.
The Proven Rules of Good Forecasting
- Why you should 'divide and conquer' when building a forecast.
- Why simple approaches work best (and what we mean by 'simple').
- The other key rules that forty years of academic research into forecasting have proven.
Structuring a Forecast
- What is meant by an 'epi-based forecast'.
- What is meant by a 'patient-based forecast'.
- What is meant by a 'sales-based forecast'.
- Fitting market access into your forecast structure.
- When to use each of the above.
- A simple totally non-mathematical explanation of how extrapolation techniques differ from each other.
- Which simple extrapolation techniques work best?
- Which ones are built into Excel and which ones require additional software.
The Impact of Product Profile on Your Market Share
- The key idea behind conjoint analysis (the most common research technique for looking at the impact of product profile).
- How to build a simple conjoint-type model yourself, without a survey for forecasting.
Day 2
The Impact of Launch Order on Your Market Share
- How and why launch order affects your market share.
- How to build a simple launch-order model to predict the impact of your launch-order.
The Impact of Promotional Spend on Your Market Share
- How and why promotional spend affects your market share.
- How to build a simple promotional spend model to predict the impact of promotional spend on your market share.
Building Market Access and Other Pharma Specific Considerations into Your Forecast
- How market access has different effects at different levels of your forecast.
- Simple market access modelling approaches.
- How co-prescription affects shares.
- How 'lines of therapy' affect shares.
- How off-label usage affects shares.
Forecasting How Quickly You Will Achieve Your Sales Potential
- Why therapy class uptakes tend to be 's-shaped'.
- Why brand market share uptakes tend to be 'r-shaped'.
- A simple non-mathematical explanation of how the famous Bass Model can help you predict the above.
- Flow/State models (new, repeat, switch etc.) and their role in forecasting uptakes.
Where to Get The Data For Your Forecasts
- Compliance and continuation/persistence.
- Epidemiology sources and accuracies.
- Diagnosis and prescription rate sources and accuracies.
- Events (which events really matter and why most forecasts are "over-evented').
This course optimally balances interactive lectures and group work on case studies that illustrate the theory and enable delegates to practice the tools & techniques. You will be provided with an Excel workbook (that you can take home on a CD-ROM) including simple exercises that you will complete at the end of each session. This will ensure you leave with real hands-on ability to use the techniques.
As the founder and Managing Director of Inpharmation, a consultancy specialising in sales forecasting and modelling for the pharmaceutical industry, Gary Johnson works with the world's top 10 pharma companies and many more.
Gary is also the expert-trainer on our popular Essentials of Pharmaceutical Pricing course of which you can read testimonials from past participants here.
Prior to founding Inpharmation, Gary spent two decades in the pharma industry holding senior positions, such as General Manager and Head of Global Marketing with a number of major blue-chip pharma companies, including SmithKline Beecham, Fisons and Schwarz. Gary Johnson is a sought-after industry speaker and conference chairman. Winner of a number of speaking and best paper awards with the EphMRA and the BHBIA, he is the author of "Evidence Based Forecasting for Pharmaceuticals" - the definitive work on forecasting (and influencing) the sales of pharmaceutical products. Other books include "Monkey Business: Why the Way You Manage is a Million Years out of Date" - finalist for the MCA Book Prize.
14-15 May 2014, Brussels
This course takes place at the Sheraton Airport Hotel & Conference Center which is situated opposite Brussels National Airport, literally at 2 minutes' walking distance from the arrival hall.
Sheraton Brussels Airport Hotel
Brussels National Airport
1930 Zaventem
Tel: +32 27 10 80 00
Fax: +32 27 10 80 80
We have secured preferential room rates at this four-star hotel for our delegates. Registering three weeks or more prior to the course will secure your room at a preferential rate. Upon your registration, C.E.L.forpharma will send you a Sheraton Brussels Airport Hotel Accommodation Sheet to complete and send back.
Do not hesitate to contact Marie Stricklesse, Senior Programme Coordinator, if you need assistance in this matter. (email@example.com; tel +32(0)27090143)25-26 November 2014, London
This course takes place at the Sofitel London Heathrow Hotel which has direct access to Terminal 5 via a covered walkway and Terminals 1, 2, 3 and Terminal 4 via courtesy Heathrow Express and connect rail connection. The hotel is only 21 minutes from Central London by train.
Sofitel London Heathrow Hotel
Terminal 5
London Heathrow Airport
TW6 2GD London
United Kingdom
Tel: +44 20 87 57 77 77
Fax: +44 20 87 57 77 88We have secured preferential room rates at this hotel for our delegates. Registering three weeks or more prior to the course will secure your room at a preferential rate. Upon your registration, C.E.L.forpharma will send you a Hotel Accommodation Sheet to complete and send back.
Do not hesitate to contact Marie Stricklesse, Senior Programme Coordinator, if you need assistance in this matter. (email@example.com; tel +32(0)27090143)
Team discounts are offered as of 3 or more registrations from the same company.
14-15 May 2014 Course, Brussels (FOR-28) Price(*) Registration before 28 March 2014 €2.670 Registration after 28 March 2014 €2.970
25-26 Nov. 2014 Course, London (FOR-29) Price(*) Registration before 10 October 2014 €2.670 Registration after 10 October 2014 €2.970
* (VAT excl.)To register, please go to our online registration form.
"I highly valued Gary's forecasting course, in particular because he illustrates the theory with many anecdotes and examples!"
Pascal Schär, Business Development & Project Manager, Vifor Pharma – Switzerland (October 2013)
"Gary's course was recommended to me by a colleague and I'm really glad I followed it. It's a very good course and fully met my expectations."
Benediekt Muylaert-Gelein, Head of Data Strategy and Reporting, Strategic Marketing Practice, UCB – Belgium (October 2013)
"Gary Johnson is a very competent expert who gave a very interesting introduction in this field!"
Harald Kattnig, Manager Business Development, Recardio – Austria (April 2013)
"The Pharma Forecasting Course with Gary Johnson is very useful and beneficial for all levels in pharma forecasting."
Javier Arilla, Supply & Demand Continuous Improvement Specialist, Teva – Spain (December 2012)
"This course did cover everything we had to learn to forecast. Highly recommended!"
Yoshi Kanezashi, Marketing Information Manager, Kowa – UK (December 2012)
"Hands-on and gave an excellent overview on forecasting techniques!"
Werner Braun, Director Strategic Market Intelligence, Sanofi – Germany (October 2012)
"Complex analysis made simple. A brilliant way of deep diving into forecasting in 2 days."
Juan Vergez, Associate Manager Business Intelligence, Merck Serono – Switzerland (June 2012)
"Excellent organized course with focus on practical execution and a lot of different examples from reality. Gary Johnson and an interesting various group made the course a perfect experience."
Sven Dehn, Market Research Manager, Roche – Germany (June 2012)
"Gary is engaging and does his best for all the participants to have them understand the content to full extent. He uses a lot of examples and exercises, so it was quite fun!"
Yuuki Ochiai, Business Intelligence Manager, Boehringer Ingelheim – UK (March 2012)
"Very good introduction to pharma forecasting with a lot of content. Gary is able to communicate his expertise very clearly!"
Lewis Pearson, Pricing & Portfolio Commercialisation Manager, Pfizer - UK (December 2011)
"An excellent grounding. The only drawback is that it leaves you wanting more."
Geoffrey Wyatt, Associate Marketing Director, Merck Serono - Switzerland (December 2011)
"Very insightful and practical forecasting event, offering useful tools and structured methodology for accurate and meaningful forecasting."
Ekaterina Smolkina, Business Analyst, Genzyme – The Netherlands (October 2011)
"Excellent lecturer. Well organized and nice structured course. Gary teaches with passion and uses simple examples and great comparisons that help in better understanding the complexity of the forecasting process."
Elisabetta Pani, New Product Advisor, Chiesi – Italy (October 2011)
"This was an interesting introduction to the theory of forecasting, and it has whetted my appetite to challenge our current forecasts."
Kate Irving, Brand Director, Takeda – UK (October 2011)
"Interesting and useful course. Especially for product managers."
Elena Pavlidou, Business Analyst, LundBeck – Greece (October 2011)
"Brilliant course, very clear and with specific advise relevant to the pharma industry. Gary is very forthcoming, sharing his 20 years experience and knowledge of forecasting in this industry."
Tatiana Freire, Customer Value Management Associate, Boehringer Ingelheim - Australia (June 2011)
"Valuable course by an excellent expert and passionate lecturer, shared with colleagues coming from all around the world."
Danilo Pelosi, Commercial Assessment Manager - Corporate Marketing, Chiesi - Italy (June 2011)
"This course has provided me with so much theory that I now can challenge the market forecasts in a much more qualified way than before attending this course."
Kirsten Rask Nielsen, Portfolio and Pricing Manager, LEO Pharma - Denmark (June 2011)
"A very good course to become more experienced in forecasting."
Rogier Woelderink, Business Analyst, Ipsen – The Netherlands
"Thanks for this interesting and enthusiastic forecasting conference!"
Elodie Privat, Sales Analyst, Alexion Pharmaceuticals – Switzerland
"Gary represents a high level of expertise. It is really helpful to analyse a current practice in my organisation and point the areas for improvement. The point is that after the course I know much more how to do that."
Slawomir Kawaler, Business Controlling Manager, Nycomed – Poland
"Quite inspiring course with significant insights for further implementation into business."
Almaz Miftakhov, Key Account Manager, Pfizer – Turkiye
"Very good overview and introduction! Gary Johnson perfectly structured this pharma forecasting course and offers lots of interesting information combined with a huge background of deep market experience."
Katharina Golomb, Product Manager, Grünenthal – Germany
"This forecasting workshop is an excellent review of fundamental concepts in pharma marketing and provides many simple insights that can be quickly used in practical applications."
Serkan Oray, Director New Product Planning CNS, UCB – Belgium
"This is the second C.E.L.forpharma course I attended. Quality confirmed!"
Barbara Ronca, International Brand Manager, Chiesi - Italy
"The Pharma Forecasting Event provides good theoretical insight and a practical model that can be applied to many different cases. This workshop was useful in providing a perspective of forecasting."
Can Sunata, Sales Force Effectiveness Manager, Astellas – Turkey
"Gary explains that forecasting principles include breaking it down and making it simple. Gary has an excellent style that includes breaking forecasting into the parts and making complex and various forecasting approaches simple and more intuitive"
Sam Morton, Senior Marketing Manager, Sanofi-aventis - France
"Especially recommended to people who work already for some time with forecasting, because Gary has gigabytes of valuable information to provide IF you ask questions! So do it, have a list of questions and you will get the answers, I am sure!"
Roland Adomaitis, Operations Manager Finland, Eli Lilly - Lithuania
"Interesting content. Practical advice. Excellent organisation. Overall satisfied and willing to suggest it to my other colleagues."
Dimitrios Tsourougiannis, Market Intelligence Manager, Astellas – Greece
"Thanks Gary, this is a very good course with animated presentations and very helpful exercises."
Lieve De Meutter, Business Intelligence Manager, Merck Sharp & Dohme – Belgium
"This is a great hands-on workshop. Gary is able to simplify pharma sales forecasting by breaking the process down and providing clarifying background information. Only an expert of his caliber can explain forecasting at such level of clarification."
Koen Jacobs, Brand Manager, UCB – The Netherlands
"A very effective course, with simple examples as well as one integrated but staged exercise to work through over the 2 days."
Avi Leaf, Marketing Manager, Takeda - UK
"Gary pitched things at the right level. His course offers a very nice mix of theoretical and practical content!"
Mark Darmody, Sales Analytics & Reporting Analyst, Shire - UK
"Very practical sessions, having the opportunity to correct some recurrent mistakes and clarify frequent doubts about the use of forecasting models. Very good presentation skills, Gary!"
Juan Miguel Quiles Martinez, Marketing Manager, Solvay - Spain
"I am truly relieved we did not just play with a model but looked at the rationale and the logics behind it, stepping back from the details. Also, Gary's knowledge of therapeutic markets spans a wide spectrum, covering both primary and specialist care markets. Very good course, thanks!"
Elena Cavalli, Associate Brand Director, Astellas – UK
"Gary has got the rare ability to shrink very complicated concepts into a very understandable discussion over only 2 days."
Claudio Lezzi, Marketing Manager, Helsinn Healthcare - Switzerland
"Gary Johnson's pharma forecasting conference provides very insightful analyses and learning points."
Peter Skov, Analysis & Forecasting Manager, LEO Pharma, Denmark
"An excellent rounded introduction to Pharmaceutical Forecasting. A quick tour through the key models over an interesting 2 days."
Jill Skinner, Director International Sales and Marketing Training, Shire - UK
"The Pharma Forecasting Course is a very good course, since it provided clear and actionable insights & tools. Both the overall content and Gary's presentation skills are very good!"
Emmanuel Joubert, Senior Manager Market Research EMEA, Bristol-Myers Squibb - France
"Gary was engaging and an obvious expert who was able to pitch complicated issues at a level people could understand in a second language. The content of his forecasting seminar was very good: perfect combination of theory and practice! The academic foundation of the programme is something I appreciated strongly."
Strategic Marketing Director, Takeda - UK
"The Pharma Forecasting Course is developed and led by Gary Johnson, a very interesting and knowledgeable speaker. This course is definitely not a waste of time, whether you do forecast or not."
Ruslan Akhmadov, Business Development Analyst, Nycomed – Russia
"Gary Johnson is a good speaker with a lot of expertise and an inspiring look at forecasting of pharmaceuticals."
Filip Schurgers, National Project Manager, Wyeth – Netherlands
"As I am involved in forecasting, I found the pharma forecasting course very useful in terms of defining concepts and learning the logic behind defending good forecasting methodologies."
Revati Nehru, Project Lead Forecasting, Novartis – India
"This is an excellent forecasting course for Asian beginners."
Atul Saxena, Project Lead Forecasting, Novartis – India
"The Pharma Forecasting Course is a very good course, simple and comprehensive at the same time."
Victoria Revilla, New Products Business Analyst, Almirall - Spain
"An outstanding course that offered all: a well-structured, understandable and comprehensive introduction to a complex subject, lots of examples from daily practice, while leaving sufficient time to clarify individual questions and providing the opportunity for working groups. A valuable course for both, newcomers as well as experienced participants, presented by an excellent speaker. All in all very recommendable!"
Monika Schuessler, Executive Manager New Business Development, Janssen-Cilag - Germany
"This is the right course if you want to learn the fundamentals of pharma forecasting from a very good teacher (i.e. Gary Johnson)"
Mazin Soubt, Global Brand Manager, Novartis - Switzerland
"An interesting overview of how we have to manage forecasts in pharma markets. I am convinced that The Pharma Forecasting Course of Gary Johnson is one of the best."
Radu Amzoi, Supply Chain and Launch Manager, Sandoz - Romania
"An excellent course covering both theoretical and pragmatic issues related to pharma forecasting. Of value to those already experienced in different forecasting techniques and approaches, as well as the uninitiated."
Alun Davies, European Marketing Intelligence Manager, Astellas Pharma Europe - UK
"Gary's presentation skills are very good and he clearly has a high level of expertise. This is a very interesting course explaining the concept of forecasting. It makes me look forward to do my next forecast!"
Sonja Buyle, Director New Product Commercialization CNS, UCB - Belgium
"The Pharma Forecasting course gave me a new view on the discipline. From something I viewed as very complex and blurred in mathematical models to a discipline that actually builds on a combination of common sense and simple models. Gary is an excellent teacher - always exemplifying with real life examples. I can highly recommend the course. "
Jacob Glenting, Business Development Manager, ALK-Abello - Denmark
"Gary does not only have an impressive expert knowledge, he is also a superb teacher and highly flexible regarding questions from the audience - a rare blend of talents! Thank you for the great seminar and it was really nice meeting you. "
Thomas Temme, Business Development Associate, Paion – Germany
"It was an excellent course & organization. Probably one of the best I ever had (many exercises, clear messages and methods)! Superb!"
Solvejg Nasert, Global Strategic Marketing & Sales - Market & Portfolio Development, Intendis GmbH - Germany
"An excellent overview of how to forecast sales of pharmaceuticals in a rational way, as well as how to put into perspective used standards on the corporate or global level... Interesting and full of handy tips & tricks to improve and challenge forecasts!"
Kathleen Van den Eynde, Business Support & OTC Director, Sanofi-aventis - Belgium
"Gary is explaining the complex world of forecasting in pharma in an amazingly practical and understandable way"
Matthias Fleischer, Sr. Manager Sales Administration, Astellas Pharma - United Kingdom
"Based on his knowledge and experience, Gary knows how to bring the complex world of forecasting to his audience in a simple and practical way. This course is gracefully simple in its concept, but complete in its content. The theory is made easily understandable with examples, exercises and group work"
Urbain Gressens, Manager Market Research & Forecasting EMS, Eli Lilly - Belgium
"A lot of basic rules on forecasting can be derived from common sense or previous experience, however this also makes it difficult to defend your forecast when challenged. Gary Johnson's seminar on forecasting provides a good overview of the rules that apply in forecasting and how these are objectively supported by research. After following this course not only will you be able to provide better and more accurate forecasts but you should also feel more confident in presenting and defending your assumptions, hypotheses and predictions."
Frank Demeulenaere, Associate Director New Product Commercialization CNS, UCB - Belgium
"Gary Johnson wants to become a "Pharma Forecasting Guru". I personally think: he is not so far away from it! The course was very useful for daily practice. Gary is able to present and teach a - on a first look - not very exciting topic in a very exciting, convincing manner. He gives useful tools and his book, given to the participants of the course, is more than useful for after-reading and learning."
Ulrike Hartmann, Medical Product Manager, Astellas Pharma GmbH - Germany
"Interesting information presented in an easy-to-understand way, mixed with exercises and little games, as well as many good examples. Gary is well versed in all aspects of the course. He is very knowledgeable in both forecasting and the pharmaceutical market"
Ingrid Heyne, Desk Research Specialist - Patient & Market Insight, UCB - Belgium
"An Evidence Based Approach" immediately applicable to practice! A great approach to this tough topic"
Albano Attrice, Product Manager Infectiology, UCB - Belgium
(Go to top of The Pharma Forecasting Course page)


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Sprint Family Locator is the convenient, reliable and secure way to find family members—instantly— from any web-enabled mobile phone or any computer connected to the web.
iPhone 4S on 3G data network too slow to be useful
No more frustration now,eft sprint a couple of weeks ago and the iphone family as well! CRICKET 4g LTE is my new family and not only am I getting > ...beeay , Regular Visitor
A manager can fix that btw as far as activation fees go if you are within the 14 day window I think. Sorry you are having problems, but it is ...Samsung Galaxy Note 3 (Updated Dec 8, 2013)


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Romwe have a Halloween event now. Here is the details:
$20 OFF for orders over $100.
Use Code: halloween20.
Offer effective from October 26th through November 1st.
Here is the preview link: romwe.com/Happy-Halloween-Sale-c-182.html
Enjoy it =)
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Buckle Black Little By Little V-Neck Sweater
SALE $47.96 was $59.95 Item #51800BB154BK- Slim fit ribbed sweater
- Button, grommet and taping accents
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Buckle Black Little By Little V-Neck Sweater 1 1
Comfortable fit great fit -very comfortable. Sweater appears to be really well made- October 8, 2011
1-1 of 1


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Road trips from Southern California: San Diego
For more destinations, visit our road trips guide.
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Looking to get away? Browse our destination and topics pages to read about vacation ideas, view photos and videos and get advice from our experts.
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Admiral Ale's Book Depot
The Federal Duck Stamps by David P. McBride, A Complete Guide. 11 Printing, 1984. This book marks the 50th Anniversary of the Migratory Bird Hunting Stamps. Included is the history of the stamps, photos of all the stamps. Media Mail w/Delivery Confirmation
All Items : Coins and Stamps : Stamps : British Commonwealth : Pre 1980
item #288708
(stock #ALE00062)
Admiral Ale's Book Depot
Marks the centenary of the Royal National Rose Society of the United Kingdom. Four types of Roses were portrayed on these stamps and have different values. A card is enclosed (as shown in photo) to better explain the different flowers. As the photo shows, this is unaddressed. The Admiral has been the sole owner of this colourful reminder of the Society's work. First Class postage, and will be mailed in a padded envelope with EXTRA cardboard backing to try to prevent bending.
Admiral Ale's Book Depot
The Story of Hundred Years of U. S. Postage Stamps written by Maud and Miska Petersham. 1947 First Edition. No dustjacket and corners show wear. Page before title page have signatures of both authors.


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Santana S, Recuero M, Bullido MJ, Valdivieso F, Aldudo J. Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells. Neurobiol Aging. 2012 Feb;33(2):430.e19-33. PubMed Abstract
Information about the stage of infection is important in relation to antivirals: Agents such as acyclovir (ACV) and foscarnet (FOS) act by preventing viral DNA replication, so if viral damage relevant to AD occurs before replication—say, during virus binding to or entry into the cell—these agents would reduce... Read more
Information about the stage of infection is important in relation to antivirals: Agents such as acyclovir (ACV) and foscarnet (FOS) act by preventing viral DNA replication, so if viral damage relevant to AD occurs before replication—say, during virus binding to or entry into the cell—these agents would reduce the damage only indirectly, by reducing the number of viral progeny and, hence, the extent of viral spread.
Santana et al. showed that FOS treatment did not visibly affect Aβ staining, even at the high concentration of 1.3 mM (1), suggesting that Aβ production induced by HSV1 is independent of viral DNA replication. Our recent experiments show similarly that HSV1-induced Aβ accumulation is viral DNA replication independent (Wozniak et al., submitted). We found that FOS and ACV decreased Aβ levels significantly (depending on the concentration used), but that levels were not reduced to those in mock-infected cells. The fact that Aβ level was reduced by FOS does contrast with the findings of Santana et al., but the result likely reflects our infection conditions (1 pfu/cell for 16 hours), which allow the virus to replicate and spread to additional cells; thus, the decrease we observe probably occurs through diminished viral spread.
The second paper, by Lerchundi et al. (3), examined the cleavage of tau in HSV1-infected cultures of neurons and astrocytes from embryonic or neonatal mice. Previously, they found that in mouse primary neuronal cultures, the virus reduced neuronal viability, caused neurite alterations and changes in cytoskeletal dynamics, and that these effects were prevented by 50 μM ACV treatment before or during infection (4,5). Also, HSV1 triggered hyperphosphorylation of tau at S202, T205, S396, and S404 (we subsequently confirmed phosphorylation at S202, S396, and S404, and detected it also at T212 and S214 [6]). Their recent study showed that HSV1 caused caspase-3-induced cleavage of tau at D421 (3), an occurrence associated with neurodegeneration. This cleavage, as well as the tau hyperphosphorylation, occurred during the first four hours p.i., and it was not significantly reduced by 50 μM ACV treatment, suggesting that these effects are independent of viral DNA replication. We, too, have investigated the effect of antiviral agents on tau phosphorylation, specifically phosphorylation at S214 and T212 (Wozniak et al., submitted). However, at these sites, unlike those examined by Lerchundi et al. (3), we found that 50 μM ACV reduces the HSV1-induced phosphorylation to the levels in mock-infected cells, suggesting that the phosphorylation at these sites is dependent on viral DNA replication. Thus, it appears that phosphorylation of tau by HSV1 is a complex process with both viral DNA replication-dependent and independent sites.
In the third paper, Cheng et al. (7) built on earlier findings (8) showing that HSV1 and amyloid precursor protein (APP) interact during transport of the virus. They show, using a comprehensive series of experiments, that the interaction between HSV1 and APP is specific (other similar proteins are less frequently associated with the virus) and meaningful (APP transport is slowed and APP location is altered in infected cells, thereby possibly affecting APP function).
All three papers stress that their data support a role of HSV1 in the development of AD, thus adding to the weight of evidence provided by earlier research (see review [9]) and three other recent studies on HSV1 and AD (10-12). References:1. Santana S, Recuero M, Bullido MJ, Valdivieso F, Aldudo J. Herpes simplex virus type I induces the accumulation of intracellular ß-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells. Neurobiol Aging. 2011 Jan 25. Abstract
2. Wozniak MA, Itzhaki RF, Shipley SJ, Dobson CB. Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation. Neurosci Lett. 2007 Dec 18;429(2-3):95-100. Abstract
3. Lerchundi R, Neira R, Valdivia S, Vio K, Concha MI, Zambrano A, Otth C. Tau cleavage at D421 by caspase-3 is induced in neurons and astrocytes infected with herpes simplex virus type 1. J Alzheimers Dis. 2011 Jan 1;23(3):513-20. Abstract
4. Zambrano A, Solis L, Salvadores N, Cortés M, Lerchundi R, Otth C. Neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1. J Alzheimers Dis. 2008 Jul;14(3):259-69. Abstract
5. Otth C et al. Journal of Neurochemistry. 2009;110:45.
6. Wozniak MA, Frost AL, Itzhaki RF. Alzheimer's disease-specific tau phosphorylation is induced by herpes simplex virus type 1. J Alzheimers Dis. 2009;16(2):341-50. Abstract
7. Cheng SB, Ferland P, Webster P, Bearer EL. Herpes simplex virus dances with amyloid precursor protein while exiting the cell. PLoS One. 2011;6(3):e17966. Abstract
8. Satpute-Krishnan P, DeGiorgis JA, Bearer EL. Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease. Aging Cell. 2003 Dec;2(6):305-18. Abstract
9. Wozniak MA, Itzhaki RF. Antiviral agents in Alzheimer's disease: hope for the future? Ther Adv Neurol Disord. 2010 May;3(3):141-52. Abstract
10. Piacentini R, Civitelli L, Ripoli C, Marcocci ME, De Chiara G, Garaci E, Azzena GB, Palamara AT, Grassi C. HSV-1 promotes Ca(2+)-mediated APP phosphorylation and Aß accumulation in rat cortical neurons. Neurobiol Aging. 2010 Jul 31. Abstract
11. Lukiw WJ, Cui JG, Yuan LY, Bhattacharjee PS, Corkern M, Clement C, Kammerman EM, Ball MJ, Zhao Y, Sullivan PM, Hill JM. Acyclovir or Aß42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. Neuroreport. 2010 Oct 6;21(14):922-7. Abstract
12. Porcellini E, Carbone I, Ianni M, Licastro F. Alzheimer's disease gene signature says: beware of brain viral infections. Immun Ageing. 2010;7:16. Abstract View all comments by Ruth ItzhakiView all comments by Matthew Wozniak
The authors have nicely demonstrated that HSV1 and APP colocalize, and that this interaction increases APP expression and alters APP distribution within cells. Yet, beyond this, it is unclear whether the reported interaction with APP is 1) specific to HSV1 versus other viruses, or 2) has functional implications for APP or HSV1 biology. Regarding the former, perhaps high-level infection of cells (at multiplicity of infection of 10, which was used in this report) with other viruses (or even herpesviruses other than HSV1) may also produce interactions with APP and/or other... Read more
The authors have nicely demonstrated that HSV1 and APP colocalize, and that this interaction increases APP expression and alters APP distribution within cells. Yet, beyond this, it is unclear whether the reported interaction with APP is 1) specific to HSV1 versus other viruses, or 2) has functional implications for APP or HSV1 biology. Regarding the former, perhaps high-level infection of cells (at multiplicity of infection of 10, which was used in this report) with other viruses (or even herpesviruses other than HSV1) may also produce interactions with APP and/or other APP-like glycoproteins. For me, though, the key question is whether these interactions alter APP or HSV1 biology. For example, does knocking down APP as the authors have done in this paper alter HSV1 infectivity (by plaque assay)? Does HSV1 versus mock infection impact amyloidogenic APP metabolism? Finally, that APP is exclusively present within the trans-Golgi network in the authors' wild-type, mock-infected cells is curious, given decades of work in neuronal cells showing membranous/endosomal/lysosomal localization of APP. Does APP trafficking behave differently in the authors' epithelial cell culture system compared with neuronal models? In my view, these are the sorts of penetrating biological questions that should be addressed in future studies. View all comments by Terrence Town
The interpretation of the data from this study relies on the assumption that APP is involved in the recruitment of the kinesin-1 motor to the cargo vesicle that is hijacked by the virus particles; this highly debated aspect (2) is not addressed in this paper. The notion that at least part of APP could serve—directly or indirectly—as an anchor for kinesin-1 (3-5) provides support for such an interpretation. Moreover, even if only a small fraction of APP normally serves such a role, viral infection could lead to post-translational modifications (e.g., phosphorylation, prolyl isomerisation, and O-glycosylation) in the cytoplasmic domain of APP that could either impair or enhance its interaction with motor containing protein complexes. Phosphorylation of APP at Thr668 is known to facilitate recruitment of kinesin-1 via the JNK-interacting protein-1 (JIP-1) (5,6). In addition, phosphorylation of threonine and tyrosine residues in APP appears to be a general mechanism for regulating its interaction with known binding partners (7). In this context, of note is that the cytoplasmic O-linked N-acetylglucosamine O-GlcNAc transferase capable of adding N-acetylglucosamine to APP (8) also targets the transcriptional co-regulator, HCF-1 (9), a host-cell factor implicated in HSV infection. Could the two events be related? It is too early to speculate. In any case, the fact that the outgoing capsids travel with APP is certainly relevant for both HSV infection and AD, even if it turns out that—in this case—APP is not the anchor that recruits the motor to the vesicle. The HSV-APP connection is still there, although more mysterious.
In his comment to this paper, Terrence Town points out that the authors find APP almost exclusively present within the trans-Golgi network (TGN), and not in endosomes. However, in our studies, we found it difficult to determine the site of residence of APP at light microscopy level based exclusively on colocalization with organelle markers. This is because the TGN, the endosomal recycling compartment, the pericentrosomal periciliary compartment—to give just a few examples—are all localized to overlapping regions, and often share "marker" proteins. Thus, part of the detected APP in this study could actually be localized to some other exocytic-endocytic compartments, in addition to TGN.
Certainly, this interesting and informative study adds to the fascinating, but far from being solved, mystery of what causes, or predisposes to, AD. References:1. Muresan, V. and Z. Muresan, Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease? Future Neurology, 2009. 4(6): p. 761-773. Abstract
2. Lazarov, O., et al., Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. J Neurosci, 2005 25(9): p. 2386-95. Abstract
3. Inomata, H., et al., A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem, 2003 278(25): p. 22946-55. Abstract
4. Matsuda, S., Y. Matsuda, and L. D'Adamio, Amyloid beta protein precursor (AbetaPP), but not AbetaPP-like protein 2, is bridged to the kinesin light chain by the scaffold protein JNK-interacting protein 1. J Biol Chem, 2003 278(40): p. 38601-6. Abstract
5. Muresan, Z. and V. Muresan, Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1. J Cell Biol, 2005. 171(4): p. 615-25. Abstract
6. Muresan, Z. and V. Muresan, c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein. J Neurosci, 2005. 25(15): p. 3741-51. Abstract
7. Tamayev, R., D. Zhou, and L. D'Adamio, The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains. Mol Neurodegener, 2009 4: p. 28. Abstract
8. Griffith, L.S., M. Mathes, and B. Schmitz, Beta-amyloid precursor protein is modified with O-linked N-acetylglucosamine. Journal of neuroscience research, 1995. 41(2): p. 270-8. Abstract
9. Capotosti, F., et al., O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1. Cell, 2011. 144(3): p. 376-88. AbstractView all comments by Zoia MuresanView all comments by Virgil Muresan
RELATED PAPERSTau cleavage at D421 by caspase-3 is induced in neurons and astrocytes infected with herpes simplex virus type 1.Herpes simplex virus dances with amyloid precursor protein while exiting the cell.


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Looking for a rental property, short stay apartment or villa? Stoit Group has the property that suits your needs!
At Stoit Group we offer a large range of properties in multiple segments. Are you looking for a furnished apartment? Or do you prefer renting a house? We will help you find the match you are looking for! We have a large range of rental properties in the Southern part of the Netherlands, especially in the Eindhoven area.
Renting an apartment or house at Stoit Group?
Are you looking for an apartment or house in the Southern part of the Netherlands? Stoit Group is the perfect solution for you! Are you an expat in need of a house, short stay apartment or villa? We have 20 years of experience in the real estate industry and provide quality services and suitable housing, tailored to meet your unique needs. Please contact us, so we can help you to find the kind of rental property you like.
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Besides our rental property services we also provide the opportunity for house owners to let their home or apartment. By offering your apartment on our website, you are reaching out to a big target audience of more than 11.000 monthly visitors (website statistics of May 2010) who are able to click through our rental properties. Do you want to rent out your apartment to expats? Stoit Group has an extensive network of international companies, such as Philips and ASML, who are constantly on the lookout for a home or apartment for their employees who are going to work in the Netherlands. If you want more information regarding renting out your home or apartment we would like to refer you to the rent out your home or apartment page.
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Are you an expat looking for a short stay apartment? Are you a house owner and want to let your home or apartment? Or are you someone who would like to rent a furnished or semi-furnished home? At Stoit Group we can make the housing match for you. We are ready to assist you in your search for a home away from home!


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Missouri State Penitentiary Redevelopment
For up to date construction updates - click here.
The Chamber was pleased to host a reception following the groundbreaking ceremonies for the new Federal Courthouse held on October 24, 2008. The new federal courthouse will anchor the Missouri State Penitentiary (MSP) redevelopment site.
Dignitaries attend the ground breaking ceremony |
Pictured left to right: Terry Dunn, J.E. Dunn Construction, Marc Ellinger, Cole County |
Rendering of new Federal Courthouse |


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FREE Standard Home Delivery when you spend £100 or more
Product Code: 00928298
Special Size Type: Case of 6
Finca El Origen Malbec 2010 SERVING:Great with everything from pepperoni pizza to venison and cranberry daube. The many layers of flavour in this red make it delicious with complex casseroles. And its zingy redcurrant character helps it partner mature ripe cheeses too.KEEPING: Drink within 6 months of purchase. Style: Full-bodied Grape variety: 100% Malbec Country region: Argentina (Mendoza) Closure: Natural Cork Suitable for vegetarians and vegans Bottle: 3 x 75cl. Alcohol by volume: 14% Alcohol units per bottle: 10.5 Alcohol units per 125ml: 1.8 Contains sulphites Montaignan Malbec 2011 ABOUT THIS WINE: Winemaker Xavier Roger has wine in his blood. His father, Jean Max Roger, is a respected winemaker from Sancerre, and Xavier has inherited his passion for making elegant wines. He studied for his oenology degree in Burgundy and Montpellier; then travelled to New Zealand and California to gain winemaking experience. Xavier finally settled in the Languedoc, and it is here that he makes his best wines. Malbec, one of Bordeaux's famous quintet of grapes, is equally at home in this region. And for this wine Xavier uses gentle fermentation and light oak contact for supple, smooth roundness. SERVING:A sassy everyday red that's great with everything from tomato salads, sausages and fresh lasagne, to punchy pizza toppings or cheese and bacon quiche. Try it with robust Spanish tapas too. KEEPING: Drink within 6 months of purchase Style: Medium-bodied Grape Variety: 100% Malbec Country: France (Languedoc) Closure: Screw cap Not suitable for vegetarians and vegans Bottle: 3 x 75cl. Alcohol by volume: 13% Alcohol units per bottle: 9.8 Alcohol units per 125ml: 1.6 Contains sulphites Licensing Act 2003: it is an offence for any person under 18 years to buy or attempt to buy alcohol Please drink responsibly ABOUT THIS WINE:This highly praised Malbec was made by Argentinean winemaker Gonzalo Bertelsen. Gonzalo has tried and tested the world's most prestigious wine regions (Bordeaux, Napa, McLaren Vale among them), and now could not be happier making wine in his home country where he can display the wine knowledge he has earned. From the high, cool vineyards of Mendoza's Uco Valley, this Malbec benefits from ageing in a combination of French and American oak barrels for 6 months. Licensing Act 2003: it is an offence for any person under 18 years to buy or attempt to buy alcohol Please drink responsibly
Country: GB


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- Appartement
1280912821_1_calabria studio_final fachada.jpg1371037918_A-016-CALABRIASTUDIO-(638X442).jpgCalabria StudioQuartier: EixampleCapacité: 2 Personnes
1 grand lit
1 Salle de bain
0 opinions0Équipements
- Télévision
- Radio-CD
- Climatisation
- Chauffage
- Machine à laver
- Frigo avec congélateur
- Vitro-céramique
- Micro-onde
- Cafetière européenne
- Ascenseur
- Balcon
- Bain/ Douche
Calabria Studio is, in spite of its reduced size, a cosy, pleasant and well-equipped space. It natural daylight and nice decoration, with attention for even somehow romantic details, will quickly make you feel at home here. Its central location in an elegant and lively neighbourhood will come in handy in your daily life.
This 40 m2 apartment is set on a seventh floor (with elevator, though there are five steps downstairs). The bright living and dining area with American kitchen, just as the sleeping area with its double bed, gives out on the balconies on the streetside, the Gran Via Avenue with its modernist houses and old plane trees. You will enjoy full tranquillity thanks to the double window. Plenty of cupboards allow you to organise your personal belongings. The practical bathroom with shower and an electrical tower heater also keeps the washing machine out of sight.
Tarifs et autres conditions de l'appartement Calabria Studio
Durée minimum du séjour: 180 nuitsTarifs (TVA inclus) depuis:Plus de 6 mois:990 €/moisFrais additionnels
Caution: 2.500 €
Autres conditionsLe prix n'inclut pas les honoraires (10% du montant du contrat + 21% TVA, avec un minimum d'une mensualité) ni eau, énergie, téléphone/internet, ni TVA le cas échéant. Le propriétaire pourrait solliciter une garantie supplémentaire à celle de la caution. -
- Quartier
Alentours de l'appartement Calabria Studio dans le quartier Eixample
The apartment is located in the Eixample district, with its precious 19th century houses built in modernist style, in an area with many typical bars, restaurants and shops where locals come. It is set on the elegant Avenue Gran Via de las Cortes Catalanes, one of the main arteries in the city, at the crossing with Calabria Street. The underground stop Rocafort (red line) is only 50m away, and in less than 5 minutes you will reach the Barcelona Fairgrounds at Plaza España, or the central Plaza Catalunya. The spacious and beautiful Joan Miró park, with its famous statue "Woman with Bird" is yours after a two-minute walk.
Type de serviceNom et adresseDescriptionEvaluation de clientsGourmet shop
Gourmet shop
Selling and tasting of top quality wines, olive oils and cheeses. In the back shop: home-made dishes.Restaurant
Fresh Catalan cuisine in a pleasant atmosphere at reasonable prices (30-40€)Health services
Health services
Professional odontologic service, always using the latest technical improvements, specialised in implantology. Relaxed atmosphere.Hairdresser´s shop
Hairdresser´s shop
A modern hairdresser´s where besides getting a new haircut you can enjoy cocktails and good music on nights of full moon.Nightclub
One of the hottest spots in Barcelona´s nightlife. Razzmatazz offers three concert rooms and two discos.fitness
This gym has the latest in fitness technology and the spa the hottest in relaxation, surrounded by gardens and swimming pools.Spa
Hot, cold and cool water baths, massages, aromatherapy and many other ancient techniques, from the traditional Arab baths.Car & bike rentals
Car & bike rentals
You will explore Barcelona in a unique way, you will see by bike the best highlights of the city. Tours are available in English, Dutch and German. Baja Bikes offers bike tours and walking tours.Music Store
Music Store
In Santa Rita you will find vinyl records, books and very stylish retro objects. This store, located in the center of the Raval, will delight every design lover.Nightclub
Good venue to go out at night, well located and all ages target.
Restaurant specialzed in Mediterranean food in an unique environment.Nightclub
Intimate space to enjoy a musical night it also turns into a nightclub from 00:00 every night.
Entry prize from 10€.
Supermarket with home delivery through capraboacasa.comSupermarket
Cooperative Supermarket with home deliveryRestaurant
Chamonix offers since 1985, 40 different dishes, a degustation menu, based on fresh market products and using the catalan traditional influences.Restaurant
Galician family excellent restaurant.of course the seafood is succulent, as well as the cosy and familiar atmopshere so difficult to find nowadays. Large wine and cheese menu also.fitness
The Olympic swimming pool is now open to the general public and offers amazing facilities if you wish to train while staying in Barcelona. Apart from the swimming pool they dispose of a fitness area, a cycling area, several programmed classes and a spa. - Evaluations(0)
Calabria Studio
Evaluations sur 0 opinions0Emplacement0Atmosphère0Confort0Nettoyage0
* Adultes & enfants> de plus de 2 ans


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Momeni Old World OW01 Gold Rug
Item #: 126OW01BURG-P Add to Wishlist
$118 - $535 + FREE SHIPPINGDescription: Elegant and sophisticated, Momeni's Old World collection could have come directly from a Rajah's palace one hundred years ago. Traditional designs with a contemporary use of color make these beautiful rugs a must to own. They are hand hooked in China using fine quality wools. The wool is meticulously dyed in small batches to create a very beautiful antique look, utilizing the abrush technique.
- Collection: Old World
- Brand: Momeni
- Material: 100% Wool
- Weave: Hand Hooked
- Styles: Traditional Rugs
- Origin: China
- Available in the following sizes: 3' 6" x 5' 6", 5' 3" x 8', 8' x 11' and 2' 6" x 8'
- Clean & Care: Vacuum regularly as new wool rugs can shed yarn fibers for up to three months. Avoid direct and continuous exposure to sunlight. Do not pull loose ends, clip them with scissors to remove. Clean liquid spills immediately by blotting with cloth or sponge. For hard to remove stains, professional rug cleaning is recommended.
The rug arrived quickly and is beautiful!It matches the picture perfectly. The quality is really good and we will have it for years to come!
RECOMMENDED: Yes, I would recommend this to a friend.Colors are much less vibrant than they appear in the image but it works for the space that I needed it for. Good quality, though.
RECOMMENDED: Yes, I would recommend this to a friend.
Though styles have come and gone, beneath them all is the fundamental principal that Momeni rugs are created to touch our senses. The Momeni standard of quality, elegance, and sophistication has been recognized time and time again with America's Magnificent Carpet Award in Atlanta Georgia.
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[Page 16 left blank][Page 17]Sunday Oct 4 Moved Hospital into Fortifications on account of the approach of the enemy.[42] 17 sick men & 11 att[endants] including convalescents.[Oct] 5. Regiment moved into fortifications in night by order of Gen Granger.[43] ?--Rebels reported within two miles. In God is our trust.[44] What harm can befal if He is our friend? Three field & Staff & three line officers came to Hospital to breakfast.Notes[42] Confederate General Joseph Wheeler had been ordered by General Bragg to cross the Tennessee north of Chattanooga with his cavalry corps and to disrupt communications of Rosecrans Army of the Cumberland occupying that city. The cavalry raid began on September 30, made some initial success by capturing supply wagons and forcing the surrender of the garrison at McMinnville, Tennesee. On October 5 the Confederates managed to destroy the important railroad bridge over Stones River just south of Murfreesboro, but by this time considerable Union forces were in pursuit of the raiders. Wheeler recrossed the Tennessee River on October 9.[43] Major General Gordon Granger (1822-76), who had been given the command of the Army of Kentucky on October 7.[44] Ps. 56:11.
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I am moving.
My family and I are packing up our house and heading further north so my husband can have a closer commute to work, and we get little more room to grow.
It has been both emotionally and physically exhausting. And incredibly time consuming.
Thankfully I have survived so far by keeping my days organized and physically planning… Read the rest


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I have been teaching Biology and general sciences as well as a smattering of other subjects in Northern Alberta since 1995.
Kinesthetic, self-discovery. I love to stay active, and have my students actively engaged in their learning process as well.
NABT -Outstanding Biology Teacher Award winner for Western Canada 2010 Prime Minister's Award for Excellence in Teaching 2013
University of Alberta Bachelor of Education, 1995
Specialty, Science, Anatomy, Biology, Earth Sciences, Environment, Anatomy, Character Education, Family Consumer Sciences, General Science, Child Care


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Home | Products | Search | Gadget of the Month | What's New | Gift Registry | Stores | Contact Us | My Basket
Post & Rail TV Cabinet Sun-Dried (PRA011-SD) |
$521.50 |
The Post & Rail collection is made of 100% recycled wood certified by the Forest Stewardship Council. Each piece is bench built in Vietnam from reclaimed pine, fir or spruce salvaged from dismantled buildings, old bridge beams, and scrapped cable reels. After assembly and sanding, Post & Rail furniture is given up to 18 hand-rubbed color applications. The hardware is is made of recycled metal. The Sun-Dried finish gives the vintage wood a bleached-out look, with a neutral color palette. 47" x 16.5" x 23" high.


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Because Knetbooks knows college students. Our rental program is designed to save you time and money. Whether you need a textbook for a semester, quarter or even a summer session, we have an option for you. Simply select a rental period, enter your information and your book will be on its way!
Brief Contents
1 The Profession of School Counseling
2 Schools: Social Institutions
3 Moral, Ethical, and Legal Issues in School Counseling
4 Qualities of Comprehensive ... MORE
5 The ASCA National Model
6 Models of Delivery Systems
7 Accountability, Action Research, and Data-Driven Outcomes
8 Counseling
9 Educating and Curriculum Delivery
10 Consultation and Collaboration
11 Leadership, Advocacy, and Coordination
12 The Delivery System in Action
13 Current Issues for School Counselors
14 Personal and Professional Issues


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You're watching...
Rep. Paul on Efforts to Make the Fed More Transparent
Rep. Ron Paul, (R-Texas), on efforts to pass the "Audit the Fed" bill.
Jul 19, 2012
You're watching...
Rep. Ron Paul, (R-Texas), on efforts to pass the "Audit the Fed" bill.
Jul 19, 2012
Also in this playlist...
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Auto-advanceThis transcript is automatically generated
All retiring at the end of this term after a long long.
Time of service had his last showdown with Federal Reserve Chairman Ben Bernanke yesterday here's a clip.
The very first -- up.
Is transparency.
And for us to know we have a right to go -- you may be.
Correcting your social least I'm sure you believe -- -- But maybe I should be top of the congress that we should stand up and say yes we -- -- to know.
Congress is expected to vote Ron Paul's audit the Fed -- next week congressman Ron Paul joining us now.
From Capitol Hill teacher is -- your last face off with Ben Bernanke.
Let's be a little disappointing -- you -- -- -- in those sessions.
For all the -- did the work you did on the Fed and you have as as much influences you probably could possibly hope to get.
On the Fed it in your position in congress of the past couple years.
Did you did you make any progress are you satisfied that you changed the Fed in some way to make the more accountable.
I think so I think they've responded.
At least superficially.
We get it more information they respond to lawsuits and and that's been helpful.
And there was some demands from.
Dodd-Frank bill.
The chairman now has press conferences.
I think it's mostly superficial we're not -- getting down into the nitty gritty.
Of knowing what happens and how how the deals are made in how they -- -- companies and.
What happened that would fifteen trillion dollars you know in emergency and what they might be doing now with.
Currency swaps -- what they plan to do it appears.
An ongoing crisis in Europe south.
Though we're making progress.
But you know as far as the -- in general is concerned we've made tremendous progress outside.
We haven't made as much progress here in Washington but because there's so many people outside -- washing your -- here I think this is the reason we're gonna have a vote on the bill next week.
And the -- was -- audit the Fed but let me just play devil's advocate here congressman you talk about more transparency.
I remember covering Alan Greenspan's Federal Reserve and there was nothing you got basically nothing except the statement -- and that was it.
Now they -- the news conferences to his credit that has really been driven by Ben Bernanke.
What else do you want to see if there was one thing that they said all right you get to pick you get one thing you want to know about the Fed won't reveal what what is that what.
Thing do you see that is really of import at this point to everybody who's watching.
I would say it's the correspondents and negotiation of deals made overseas.
And that is what they cling to the most of and Bernanke claims that he needs independents that what he wants to secrecy he says he'll be chaos -- we now.
It even my bill I think it's rather -- it has nothing to do with monetary policy.
In his claim and we'll have all -- Ramifications.
That we will immediately change how he acts now it would be the embarrassment -- we knowing what he does and how we talk to other countries.
Other central banks who gets bail now and why they do it.
That he would be it will not be immediate various delay in getting this information.
So why yes there would be a change that we have a responsibility to know this.
Especially when you talk and that many trillions of dollars his budget is much bigger than what -- I just doesn't.
It's -- -- you mentioned the correspondence with what happens overseas because quite recently of course with Barclays -- -- -- scandal we have -- questions of what happened between the New York fed which of course part of the big Federal Reserve.
And Barkley spank it appears.
That the New York fed if not encouraging low -- rates in a way that might have been against the law were at least acknowledging that -- -- was doing that -- is is there going to be any action taken.
About the New York fed because of this.
All that remains to be seen I doubt -- too much will happen but boy I think your point is very important.
Because I think if they knew -- we would have access to all these records.
They would be more transparent and they -- -- say well we can do all this Wheeling and dealing and planning.
I mean that is the job of the -- They see -- so so important and -- fixing interest rates mean they fixed rates so the economic principles identical.
2 banks in central banks whether it's leave Libor or whether it's overseas overnight rates here in this country it has the -- economic consequences.
And I think an audit if the other -- -- deal had been in place we would have -- a lot sooner about this and maybe he would never have occurred in there would have been no negotiations.
Going on between.
The banks in our Federal Reserve we'd be remiss if we didn't ask you before you go -- you'll be heading to the Republican National Convention you're encouraging your delegates to still go looking at Mitt Romney.
A lot of people are saying he hasn't put forth -- jobs plan that has any real opportunity to really change things here.
How do you feel about him as a Canada.
Well compared to know.
The value you know he's he's certainly.
Offers different things than the current president.
I think the current conditions in this country make you refer anybody no matter what because the conditions.
Are in terrible shape they've been developing in this manner in this direction for many many decades -- -- who is to be president they are going to happen.
Very very tough job because you have to were were reversed an entire way of thinking god no more deficits and less spending and change in foreign policy.
Change in our monetary policy so it's going to be a major -- -- -- anybody will you vote for Mitt Romney.
I'm I'm not -- not made -- decisions.
-- by the way your friend Peter -- was just -- saying we are going -- -- recession.
You think so too.
Yeah -- if you took if you look at these many many people unemployed -- -- go by the statistics.
Williams you know I'm not private -- you know -- -- center employs some of them -- -- a depression and out where invention where much worse.
Then this statistic shows one -- I -- I hear from my young people that.
I like to come to my rally say well at least you're telling the truth and I don't believe what government tells them they don't believe that what they tell about.
How well we're doing in Afghanistan they don't believe.
That the government tells them correctly how much inflation there is or how serious the economic problems 24 years of service congressman -- -- -- thank you.
And by the way has made service was delivering babies 1000 babies were delivered by this doctor are you gonna go to deliver more babies in Texas.
It would it would be finally gets what they didn't argue with me as much as a politician -- -- -- -- doctor right.
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Vollrath® Super Pan 3™ Plastic Steam Table Pan
System brings together Standard Stainless, Perforated Stainless, Non-Stick Stainless, High Temp Plastic, and Low Temp Plastic Pans- INTERCHANGEABLY. Every style of Super Pan 3 can be used together.
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Mid-High skill player, can play any roll, understands ganking is map aware plays with pride, places wards and owns. Sometimes I have bad games and I have plenty of experience in hon & dota. PM me in game or post here if interested.
Low PSR ATM but Just had an awful team who continued too bait me over and over. I'll get it up. Check my stats!


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Tanya is a spirited 22-year-old with dark, cropped hair, a penchant for body art, and a secret. On a chilly October afternoon, she sits at a round wooden table in a knitting shop in New York City and shows off her latest tattoo. Her companion, a 56-year-old nurse practitioner named Susan Ledlie, examines the design and grins, pulling up her sleeve to display her own.
Ledlie and Tanya (name changed) are an unlikely pair. Ledlie, a plump older white woman with a brisk maternal air, teaches graduate nursing at Molloy College in Long Island, New York, since retiring from her job as a nurse practitioner in 2010. Tanya, young and black with a cavalier attitude towards adulthood, grew up with her grandmother in Brooklyn, NY and wants to be a hairdresser. Yet the two have been close friends for 16 years. In 1995, when Tanya was six years old, her grandmother took her to Ledlie's clinic in Brooklyn. Tanya had HIV. She had become infected at birth when she came in contact with her mother's blood, and was diagnosed soon after.
"The first time I saw Susan, I remember I had to get my shots for school," says Tanya. "I was kicking and pushing Susan and she had to bring three other doctors in to hold me down." From that day forward, Ledlie saw Tanya at least once a month, as her primary Aids care provider - a role that included prescribing drugs, doing regular medical checkups and providing teenage counselling. "Visits became like a family thing," Tanya laughs.
Ledlie's role was almost unthinkable three decades ago. In June 1981, the US Centers for Disease Control and Prevention reported the first known case of what would eventually become known as Aids. Just a year later doctors began to diagnose the disease in children. Initially, they were treated with zidovudine - the first antiretroviral medicine designed to treat HIV - or nothing at all. During these early years of relevant ignorance about the disease, 45% of HIV-positive children died before their tenth birthdays. "We were focused on pain relief and comfort, without any thoughts about the child's future," says George Siberry, an adolescent HIV expert at the US National Institutes of Health.
But in the years since Tanya was diagnosed, there has been a dramatic shift in what it means to be born HIV-positive, particularly in western countries. Today, babies born to mothers infected with HIV receive anti-HIV medication within hours of birth and are not breast-fed so as to avoid passing the virus from mother to child. As a result, fewer than two babies in every 100 born to HIV-positive mothers in the US and Europe become infected with the virus. With treatment, 95% of kids now reach the age of 10. "Since antiretroviral therapy, we've showed they can live well into adulthood, although we don't know for how long," says Siberry.
This is Generation HIV. They are the first kids and young adults to have battled a lifelong infection since birth, and scientists are trying to understand what that really means. "There are so many unanswered questions," says Yvonne Kingon, an HIV nurse practitioner in New York City who now treats Tanya. "Are these kids' immune systems the same when they've been fighting a virus since birth? What does it mean to be an adult and have been on multiple medicines throughout your life?" she says.
A long-term study of 450 HIV-positive youth aims to answer some of those questions. The Pediatric HIV/AIDS Cohort Study (pHAcs) began in 2005 and now has 21 sites across the United States. Researchers are studying two groups of adolescents: those infected with HIV at, or shortly after, birth, and those who were exposed to treatments as infants or during foetal. They hope to understand the effects of the long-term use of HIV medications and the impact of HIV on the biology and psychology of these children. Infectious disease specialists have been closely watching these young survivors, analysing their cellular makeup and immune health, and characterising the HIV virus in the context of these patients' infections. The study will also collect information on immune function, neurological development, cardiac function, bone growth and metabolism. Siberry says the early results show some worrying results, such as increased risk of heart attacks, attention deficit and language learning abilities, as well as higher rates of asthma. "But we won't know for sure until we've followed this pioneering group into their 30's, 40's and 50's," he says.
'Dangerous secret'
According to the United Nations, at the end of 2010, there were 3.4 million children (under 15 years of age) living with HIV around the world – nine out of 10 living in sub-Saharan Africa. Every hour, around 30 children die as a result of Aids, but in the developed world, paediatric HIV has morphed into adolescent HIV, and brought with it a fresh set of obstacles. When Ledlie started as a paediatric HIV nurse practitioner in 1991, most kids who came to her clinic died by age three or four. "They stopped crawling and holding their bottles…they became stiff as a board until they died," she says. But a couple of years into her practice, she reached the first landmark in her fledgling career. "The first kid whose kindergarten graduation I could go to, that was a big thing," she says. "It was like, 'wow'."


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Is mophie pack ready for ipad mini?
- Asked by Catherine U from Muntinlupa City
- 05-Dec-2012
- Flag as inappropriate
1 Answer from the Community
Sure! Plug the cable that came with your iPad Mini into the USB-A port (the wider one) and you should be good to go. While Mophie (as of this writing) has yet to state specifically if the Powerstation will take an iPad mini from empty to 100%, I'm going to venture to guess it will be pretty close.
- Answered by Jorn K from Farmington
- 10-Jan-2013
- Flag as inappropriate
Related Questions
Is it best to keep the Juice Pack always fully charged so it is ready or when the charge is needed connect the Mophie Pack & turn it on?
- Asked by Kent T from Salt Lake City
- 27-Feb-2012
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- Asked about: mophie Juice Pack Powerstation Exte…
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How do I charge Mophie Juice Pack Powerstation Mini (the Mophie itself) while in Europe-what do I need-other than what comes packed with the Mophie?
- Asked by Nina M F from Midland Park
- 22-Sep-2013
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- Asked about: iPhone
what is the difference between the Mophie juice pack and this battery charger?
- Asked by Lu K
- 08-Dec-2013
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- Asked about: Incase Portable Power 5400 for iPho…
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Martha & the Vandellas
Martha & the Vandellas artist page: interviews, features and/or performances archived at NPR Music
Martha & the Vandellas artist page: interviews, features and/or performances archived at NPR Music
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In general abs machines poorly and is not good in mechanical applications because it deforms when heated.
Hi everyone,
I'm looking to build some small devices. I'll be turning most of it by hand with a small lathe. The outer diameter is about 15mm, with a central 10mm hole and a few 1-3mm holes drilled throughout the body.
I need a material that is, first most, light weight. That seems to point to ABS or maybe Delrin. Then for the machinability I'm tending towards Delrin.
Any other suggestions? Will ABS give me trouble with welding-chips unless I flood it with coolant?
In general abs machines poorly and is not good in mechanical applications because it deforms when heated.
Is there an alternative to ABS & Delrin that has the low-mass but machines well?
Hello. I think the best material is ERTALYTE TX. View schedule with the coefficient of friction.
I don't think that material is readily available from my suppliers (e.g. mcmaster-carr).
I'm more inclined to choose the best out of these materials (the best in terms of mass, machinability, and cost):
-Delrin (Acetal)
(see http://www.mcmaster.com/#plastics/=70qy0i for more)
Go with your first choice Delrin, the best of what is in your list is the Peek but the cost
you may not want to pay for your parts
The Ertalyte TX , the TX means it has lubricant added & is great for bushings etc, Ertalyte by itself does not have lubricant added & is slightly better than Delrin for some things
The order of the best to machine from your list
Delrin Peek
ABS Acrylic
It depends on what your part is for, & how much strength you need for your part, that will determine the wall thickness
That is easy to do, .1mm wall is when it gets a little trick just did some at .8mm wall
You should not use auto oil,it is not designed for use as a cuttng or machine lub,But WD-40 will work quite well for finishing cuts, if you can't have flood coolant, You should use coolant for cutting almost everything, it's better for tooling, better for finish & for stress free machining