text:
We loved visiting here and if you're so inclined you can attend a Catholic Mass. There's a nice gift shop, a museum, and lots more. The actual church is very large and inside there is a chapel. I would recommend this when in Assisi.
We loved visiting here and if you're so inclined you can attend a Catholic Mass. There's a nice gift shop, a museum, and lots more. The actual church is very large and inside there is a chapel. I would recommend this when in Assisi.
I loved this church. It was peaceful and amazing art and I loved the chapel of St Francis. I visited twice on my stay in Assisi. We had Mass in the crypt. The gift shop was terrific, pay toilets don't forget coins, there is a museum that costs a few euro but I skipped that.
This church houses the small chapel in which St. Francis prayed in the forest. It has recently been restored.
The treasure inside the Basilica of Santa Maria Degli Angeli is the Porziuncula, a medieval chapel that is said to be where St. Francis died. It is simply lovely and simple. the basilica itself is quite big but not so interesting artistically (my opinion of course) however, there is much to see there for those who love the story of... More
You do not want to miss this church if you are in the Assisi area. To see a church within a church and all the beautiful paintings is very special.
By this Basilica and Porziuncola inside the basilica . Maybe because my husband has Francis in his name, but when the ray of light shone through the window shooting a beam of light right at his feet it was hard to beat. St Francis's little chapel , a church inside a church, was very spiritual and a highlight of our... More
What you don't expect when you go inside the church is to find the perfectly formed little church of the Porziuncola. Breath taking to see. Went there on 2nd August when it's said you will receive 'The Pardon of St Francis' when you go through the church! Fingers crossed it worked! Stunning.
A very impressive, well maintained, basilica. Inside the Porziuncola: a little church inside the basilica. There is a museum inside, access for visiting allowed during the day. In the evening access allowed for silent prayer. Definitely worth a stop over.
Since this is on the way to Assisi, it's well worth a visit! Was surprised to see such stunning architecture and artwork in such a nondescript, small town area. Give yourself at least and hour or so to explore...
It is very easy to get around this little town. So many shops selling excellent locally made hams, salamis, olive oil, cheeses, truffles and bread. A gourmet's delight.
If you own or manage Santa Maria degli Angeli, register now for free tools to enhance your listing, attract new reviews, and respond to reviewers.
Manage your listing


text:
I've been working in the real estate industry for nearly a decade, so my friends often come to me with real estate-related advice. One of the questions I hear most often is, "Why should I hire a real estate agent when I'm buying commercial real estate? Why can't I just broker the deal myself and save on the agent's commission?" Well, the following checklist should help you decide whether or not you need a professional real estate agent for your Florida commercial property transaction.
Do you have a working knowledge of the real estate laws in your region? Real estate transactions are subject to a startling number of legal regulations. In order to successfully broker a deal, you'll need to be familiar with both land law and contract law or risk running afoul of the law and incurring hefty fines. If you don't have any legal foundation, you'll find it difficult to ascertain whether the property contract you're signing is legally sound. Property agents, on the other hand, have great expertise in this field and will be able to analyze your property contract extensively to ensure that the transaction proceeds in a fair and legal manner.
Next, do you have a nuanced understanding of the prevailing real estate market conditions? The real estate industry is notoriously volatile with prices changing all the time. Many laymen end up buying a piece of commercial property at a much higher price than they would've paid if they had waited for a few months because they aren't aware of current market trends. Property agents are not only trained to predict property market trends, but may also have access to "insider information" that will help you make a wise decision.
As you can probably tell, I'm a firm advocate of getting a professional property agent from companies like Century Retail to oversee your commercial property transaction. Real estate deals are incredibly complex and if you want the transaction to go smoothly, it's always best to seek professional advice if you lack specific training in real estate investment.

subset: commoncrawl


text:
A legacy of care
Check out how we help our community
Check out the yearly report
Check out our achievements
Hear directly from our patients
Help our community
Find where you need to go
Get in the know
Plan a visit
Send a card or a gift to a patient
Helping ease kids' nerves & worries
Private room care
Caring for newborns to teens
Helping children manage diabetes
See All Classes & Events »
Free class for first time parents
Helping siblings learn the adjustment
Teaching car seat safety
Resources for protecting our kids
Teaching kids healthy habits
Teaching kids about fire
Informed kids are safer kids
Education leading to prevention
Beyond the hospital walls
Health information for parents
Health information for kids
Health information for teens
Resources for providers
An assortment of educational resources
Info to keep kids safe & healthy
Sick of step aerobics? Tired of tennis, but still want to stay in shape? If you're looking for something to shake up your workout routine, try t'ai chi. T'ai chi (pronounced: tie chee) is great for improving flexibility and strengthening your legs, abs, and arms. Get ready to "Part the Horse's Mane," and give t'ai chi a try!
When you think about martial arts, karate and judo may come to mind. T'ai chi, sometimes called t'ai chi chuan, is also an ancient Chinese martial art form that was developed to enhance both physical and emotional well-being.
It's been said that t'ai chi is a combination of moving yoga and meditation. A person performs t'ai chi by practicing breathing exercises and a series of slow, graceful, flowing postures (also called poses) simultaneously. The postures consist of movements that are said to improve body awareness and enhance strength and coordination. Many people who practice t'ai chi say that they feel more peaceful and relaxed after a workout.
T'ai chi was developed in ancient China as early as 225 AD. The ancient Chinese believed that the body was filled with energy, or chi, but chi could become blocked, causing illness and disease. They believed that a person could help improve the flow of chi throughout the body and improve health by practicing t'ai chi exercises.
The many different styles of t'ai chi include:
The different types vary in intensity and focus. For example, Sun style is known for its fast footwork. The low-impact movements of Hao style can be practiced by people who are elderly or have special needs. In general, though, practicing t'ai chi improves strength, flexibility, and respiratory function.
You have many choices when it comes to choosing a t'ai chi workout. Many fitness centers and YMCAs offer t'ai chi classes, and many t'ai chi instructors also offer private classes. You may also want to try a t'ai chi video — there are several excellent videos just for beginners. Instructional websites, CD-ROMs, and books are also available to help you learn more about t'ai chi.
Before you start your first t'ai chi workout, you should dress comfortably so you can move and stretch easily. Shorts or tights and a T-shirt or tank top are great choices. Because t'ai chi is a martial art, some people who practice it wear a martial arts training uniform. T'ai chi is usually practiced barefoot or in comfortable socks and sneakers.
During a t'ai chi class, you'll participate in forms. Each form is a series of movements (also called poses) performed in a specific order. The poses that make up the forms sometimes have visually descriptive names, such as "White Crane Spreads Its Wings" and "Grasp Sparrow's Tail."
Here are a few poses that you might encounter if you take a t'ai chi class or watch a t'ai chi video:
Before you begin any type of exercise program, it's always a good idea to talk to your doctor, especially if you have a health problem. But unlike many other sports, t'ai chi is based on continuous, flowing, low-impact movements, so it's a good workout choice for just about anyone.
Is your schedule jam-packed with school, work, and social activities? Here are a few tips for fitting in fitness and staying motivated:
There's one caution about starting a t'ai chi routine, though: Once you start, you might not be able to stop!
Reviewed by: Mary L. Gavin, MD Date reviewed: November 2011


text:
Chinese-American engineer Hu Zhicheng, arrested during a 2008 visit to China on charges of stealing state secrets, is prohibited from leaving the country even though authorities have dropped all charges. His daughter is working to bring him home.
Font Size:
Daughter Fights for Return of Dad Trapped in China
The Associated Press
March 15, 2013


text:
Licensed EDGE Content
Filter Articles
Article Type
- Prosthetics
- Orthotics
- Pedorthics
- Upper Limb
- Lower Limb
- Pediatrics
- Sports/Recreation
- Patient Care/Rehab
Page Count
Click on the article title to view a PDF sample of the article. Please note that the PDF files are samples only and are produced in low, web resolution. EDGE Custom Publications customers will receive a high-quality, press resolution version of their selected/licensed article(s).
You have 0 favorites
Click the star icon to the left of an article to select or deselect your favorites. Once you are finished selecting your favorites, click the link above to review the list and email it to an EDGE Custom Publications specialist, who will help you build your publication.
Article Title |
Pages |
Original Print Date |
Armed for the Future: DARPA's Revolutionizing Prosthetics Project Nears Completion | 3.5 | December 2009 | |
DARPA's RP Arms in Transition: From Miracle into Reality | 3.5 | May 2011 | |
Fueling a Life Lived Large | 3.5 | June 2011 | |
Seeking the Perfect Marriage in Prosthetic Liners | 3.5 | February 2008 | |
Sock It to Me! Good Footwear Starts with Good Socks | 3.5 | November 2011 |


text:
- Apartment
Marina PlayaArea: KontxaCapacity: 8 Guests
3 Bedrooms
4 Single beds
2 Bathrooms
0 comments0Amenities
- Fridge with small freezer
- Glass-ceramic stove
- Oven
- Microwave
- Spanish coffeemaker
- Kettle
- Toaster
- Shower
- Bath
spain > basque country > san sebastian
New accomodation in San Sebastian!
This spacious, fully refurbished holiday apartment, is situated in the very centre of the city, just round the corner from La Concha Beach. The apartment is located on the fourth floor of a building with a lift, in a small street close to the main shopping area of San Sebastian (just three minutes walk). Marina Playa has been prepared to take comfortably in up to eight people.
In the accommodation, there is an elegant open plan lounge-dining room. Within the dining area there is a large table and sitting for up to 8 people, while in the lounge area there is a comfortable sofa-bed, a couple of armchairs, a TV and a DVD player. There is also a French window with direct access onto a balcony. Next to the lounge-dining room, there is a fully equipped kitchen. Here you will find everything you may need in order to prepare the meals during your holiday with friends or family. One of the bathrooms is also situated next to the kitchen. On the other side of the holiday apartment there are three bedrooms and another bathroom. The main double bedroom has a queen size bed and a French window with access to another balcony. The other two bedrooms have single beds; one of them, two twin beds and the other a trundle bed.
The vacation apartment also offers the possibility to rent a space in the parking located underneath the building. This is advisable if you are considering coming to San Sebastian by car.
Just a few metres away from Marina Playa there are all sorts of services such as bars, restaurants, supermarket…
The holiday accommodation Marina Playa is a perfect option for your visit to San Sebastian for many reasons. The main one is its location, in the city centre, but also because of the peacefulness and brightness you will enjoy thanks to be a high floor apartment.
Rates and other Marina Playa apartment rental conditions
Minimum stay: 3 nightsRates (including taxes), from:Price per night:140 €Price per week:980 €Price 1 month:4.200 €Surplus from 3 guests: 20 €/dayOnly for stays shorter than 30 days:Other chargesCheck-in / Check-out:15 € / 10 €Check-in on Sundays:30 €Check-in after 20h:30 €
Deposit: 200 €
Other conditionsThe price includes agency fees, bed linen and towels, weekly cleaning service, bed linen laundry in the apartment, internet, water and energy costs (up to 150 €/month for stays over 30 nights). The price does not include parking nor VAT if applicable. -
- Area
Surrounding of the apartment Marina Playa in the Kontxa neighbourhood
- Comments(0)
Marina Playa
Ratings over 0 comments0Situation0Atmosphere0Comfort0Cleaning0


text:
The amount of memory is like the size of a tank, say the tank holds X gallons of stuff. The bandwidth is how fast you can fill or drain the tank, say Y gallons per second. You can argue about whether the tank is big enough for a given purpose (X), and you can argue about whether you can fill it fast enough for a given purpose (Y), but what would it mean to talk about the quantity (X*Y)? That's the total memory the system can process in a second.
PS3 GB/s Memory Total
22.4 GB/s x 256MB = 5734.4 GB/s
25.6 GB/s x 256MB = 6553.6 GB/s
ps3 total: 12288.0 GB/s
GB/s Memory Total
22.4 GB/s x 512MB = 11468.8 GB/s
256 GB/s x 10 = 2560 GB/s
x360 total: 14028.8 GB/s
There we have it. The Xbox 360 can process more memory in a second than the PS3. Seriously, how can anyone argue against this?
P.S :: I am not being very original but I don't know tupence about these stuff so I'm quoting someone from the IGN BOARDS. Is this true. DISCUSS
the extremely high number is the bandwidth to the edram on the gpu as far as i understand it. it really doesnt count for system bandwidth in the manner they say it.
now i re-read what you're saying... that makes no sense.
ps3's real total: 48gb/sPS3 GB/s Memory Total
22.4 GB/s x 256MB = 5734.4 GB/s
25.6 GB/s x 256MB = 6553.6 GB/s
ps3 total: 12288.0 GB/s
GB/s Memory Total
22.4 GB/s x 512MB = 11468.8 GB/s
256 GB/s x 10 = 2560 GB/s
x360 total: 14028.8 GB/s
xbox's real total: 22.4gb/s + 256gbs (that doesnt really count in the manner they make it out to)
its not 22.4gb per 1mb of ram... it doesnt matter if they had 2024mb of gddr3, the transfer speed would still be 22.4gb/s
Why not ?? Care to elaborate ??
say your local gas station has a flow rate of 1 litre/second on their pumps.
you drive in your car with its 50 litre tank. it takes 50 seconds to fill.
next comes a bigger car with a 200 litre tank. it takes 200 seconds to fill.
just because there is more room to fill doesnt mean the petrol-pump is magically going to be able to fill faster. the size of the tank does not increase the speed, merely the capacity.
*i have no technical knowledge to back this up, but everywhere else ive looked the transfer speed is the same as i have stated, common sense dictates that having more ram doesnt suddenly mean you can transfer it faster and also 14028.8gb/s sounds absolutely absurd to me*
xbox GPU communicates with the 10Mbytes EDRAM (on the gpu) at 250Gb/s, so that's internal bandwidth between the Gpu core and the GPu Edram only.
Its not a bad thing! its usefull in some things.
but Outside the GPu, everything communicates at 22.4Gb/s... so those 250Gb/s are irrelevant to the rest of the system. you cant Add 22.4 + 250 because its apples and bananas!
The only advantage of that Internal GPU bandwidth is Aliasing filtering without almost any perfomance penalty.
Microsoft trick you into believing in false facts.
1 + 1 is always 2,
but for microsoft 1 + 1= 3 because one of the 1's is a little larger... its nonsense
Actually, the speed between the eDRAM and the R500 is only 32GB/s real bandwidth, the speed between the logic inside the eDRAM chip and the 10 MB of memory in the chip is 256 GB/s. ATI has been quoted as saying this.
Actually, if I followed the presentation right (I only listened to audio), it suggests that PS3's real total would be about 83 GB/sec. Reason being that the FlexIO bus can be used to read and write from/to the oppposite device memory. i.e., the CPU can access main memory with it's main mem bus but can also use FlexIO to access video memory.ps3's real total: 48gb/s
I wouldn't take this entirely to heart just yet unless someone were to confirm that part of it, but it's probably safe to assume you can access both simultaneously. I think the GPU->CPU is 15 GB/sec and the CPU->GPU is 20 GB/sec. Granted, this bus has more purposes than just memory access. Main reason the CPU->GPU is faster is because you need to transfer render packets across this bus as well. It's more of a general-purpose point-to-point bus, so it's probably best counted separately.
In any case, I said elsewhere that the eDRAM DOES help the efficiency of the GPU by itself. But its bandwidth is not point-to-point at all. It does not communicate externally at that full 256 GB/sec, so it is therefore not comparable at all to the point-to-point memory busses. Considering again the fuel tank analogy that Rapture brought up...
Say that your 200 litre tank was actually constructed as two smaller 100 litre tanks that are connected by a very high flow tube -- one that can handle flow rates of up to 20 litres/sec. If the pump at the fueling station only fills up the tank at 1 litre/sec, does the tank fill up any faster for your 20 litre/sec tube?
Cell phones have changed mankind. Finally, men have something they can flip out and argue "mine is smaller than yours."
Hey cpiasminc... if what you're saying is correct, does that mean that the GPU could read/write directly to main memory? aka they could use the flexio bus to access the XDR instead of having to go through the CPU?
Yes. This was confirmed by Kutaraji himself. The Cell will be able to have access to the VRAM, while the RSX could do the same with the CPU's XDR memory. In addition both Cell and RSX has independent bi-directional bandwidths, so no slow downs.Originally Posted by Mordecaii
Yes, but my question was whether or not the GPU would go through the CPU to get to the XDR or whether it has a straight path directly to the XDR via the FlexIO bus...
The FlexIO bus is not direct to memory -- rather, the GPU would use the FlexIO bus to queue requests onto the XDR controller on the CPU. There's added latency all right, but the only XDR controller in the entire system is on the CPU, so you have to use its DMAC. While the actual CPU *cores* themselves aren't involved (the DMAC gets a device ID with each request, so it gets routed directly), you can't go direct to the opposite RAM block. Similarly, the CPU can't directly access GDDR-3. It has to queue requests onto the GPU's mem controller, AFAIK.
Cell phones have changed mankind. Finally, men have something they can flip out and argue "mine is smaller than yours."
Ok, let me reword my question... The GPU has to make a request to the CPU to access the XDR... We know that there is a direct bus link between the CPU and GPU, but would the CPU have to use that bus to transfer the data that was requested by the GPU? Or can it make the request to the CPU and the CPU sends it by way of the FlexIO (which does not take up any of the bandwidth of the direct CPU-GPU bus or the GPU-GDDR bus)? If it can transfer it seperately through the FlexIO then this really increases the bandwidth and in my opinion shows just how flexible the PS3 architecture is.
The direct bus link between CPU and GPU IS the FlexIO bus. So when you're transferring data from GDDR<->XDR, you end up using that bandwidth. That's why in my earlier post, I still said it's worth considering FlexIO bandwidth separately because it's not exclusively for memory transfers.
In practice, this is why you'd never use the FlexIO bus for memory transfers while also needing to render. You'd use it, perhaps for framebuffer readbacks so you can do some post-processing or something. Either way, if you're using bandwidth to transfer from XDR->GPU->GDDR, you are, at that moment, utilizing bandwidth that might otherwise be used to transfer renderpackets and instructions.
It's not that different from the way AGP cards could access main memory without the intervention of the CPU (well, because the Northbridge houses that control), but you still only have one outgoing/incoming link from CPU<->AGP bus, which is through that Northbridge. Except with FlexIO, it's much faster, and much lower latency... then again, carrier pigeons would be lower latency than goddamn AGP. [mini-rant]
Cell phones have changed mankind. Finally, men have something they can flip out and argue "mine is smaller than yours."
Ok, I know what you're saying now, I was hoping that it was something that I hadn't heard as of yet, but I've been reading over at B3D that the PS3 GPU should be able to store and transfer things in XDR and GDDR simultaneously, so they would be able to split up some of the workload and alleviate some of the BW issues.
MAAAN, you have really NO IDEA of what you are talking about.Originally Posted by sub1zero
It´s so absurd, that there´s no point discussing it. So PS3 has 22 GB/s PER Megabyte of memory
And those 10MB people are talking about for 360 are the same PS2 have 4MB, and people say it´s waaay too few.
If 4MB is too few for PS2, for sure 10MB is not enough for 360.
PS2 could also use the shared 32MB for video, the same way the 360 can use the 512MB.
The REAL trick on PS3 is:
Cell can ALSO use the GPU memory, and RSX can ALSO use the Cell memory.
Cell can feed the video buffer directly , without using the RSX. Exactly what they did with the London (Getaway) demo. Everything you could see there was done in real time by the Cell ONLY. No GPU was used. And the Cell could use the 256 + 256 MB
Cell and RSX together is something new and unique, waaaaaaaay beyond X360.
The last trick: It seems the huge 256GB/s bdwdth between the GPU and 10MB cache is not really true. 256GB/s is actually between the edo logic and the ram itself... no more than 32GB/s link GPU and Edo. Anyone could confirm this ????
But again, 4MB of cache was too few for PS2, so 10MB is too few for X360.
There´s no more escape for Microsoft. X360 is the new Dreamcast, unfortunately.
Yes, everything you said here is correct, and is confirmed.Originally Posted by rpgamer_2k5
It´s AWESOME.
Yeah, the 256GB/s of bandwidth is only between the logic and eDRAM. The bandwidth between the GPU and the eDRAM is 32GB/s write and 16GB/s read.The last trick: It seems the huge 256GB/s bdwdth between the GPU and 10MB cache is not really true. 256GB/s is actually between the edo logic and the ram itself... no more than 32GB/s link GPU and Edo. Anyone could confirm this ????
"Please understand that in cases where the OS itself is acting in an unstable fashion, this software could behave in unpredictable ways. Unfortunately, this happens to be the case at all times with Microsoft OS's." - Japanese PC game disclaimers!
There are currently 1 users browsing this thread. (0 members and 1 guests)


text:
Nice quite area near to Julian. Comfortable room. Heater in bathroom (need that for my home!). I wanted a hook to hang my shirt in the bathroom. It was there. I wondered if the outside stairs were too dark coming back late at night. Then noticed each step had a low level light. All the trails were lighted too. Nice... More
- Also Known As:
- Butterfield Hotel
- Butterfield Hotel Julian
- Butterfield b&b
- Official Description (provided by the hotel):
- Butterfield B & B is located in the Whispering Pines neighborhood of Julian on a three-acre wooded hillside approximately one mile from the downtown area. We have five guest rooms, a parlor, and guest pantry. Amenities include private in-room bathrooms, free WiFi, cable TV, VCR, DVD, CD players, extensive video library, books, games, and fireplaces in three of the rooms. A full two-course breakfast is also included and we are able to work with your special dietary needs. ... more less


text:
Pipewalk – Puzzle Game using Javascript and Canvas
I've been tinkering with the fabulous ImpactJS game engine lately, and having an absolute blast. The man behind it, Dominic Szablewski, is a great guy, and he's done a terrific job with Impact. My latest creation with it is Pipewalk, a puzzle/board game where you attempt to supply green ooze to a board full of pipes by rotating them until they are all connected. Its actually a take on a common linux game called Netwalk. It uses canvas, so it'll only work if you're using a browser which supports it. Other than Impact, I also used jQuery/jQuery UI and the excellent Absolution jQuery UI theme by Michael Vanderheeren, as well as Uniform for styling form elements.


text:
Critic scores range from 0 to 100, with higher scores indicating more favorable reviews.
Dumont's rigorous, serious attention to the mysteries of good, evil, and faith rewards those willing to be confounded. Read full review
Bleak and compelling. Read full review
Devotees of Dumont's earlier films – particularly his 1999 film "Humanity" – will instantly recognise the style, the locale, the narrative, the bizarre quasi-realism, in which events take place in a world infinitesimally different from the one we inhabit. As ever, the visionary, radioactive glow is compelling. Read full review
Bruno Dumont's employment of his bucolic French backdrop here attends to Hors Satan's muddying spiritual ambiguity. Read full review
Ultimately less an arty provocation than a secular invocation, Outside Satan seems almost helplessly exploratory, an honest account of groping for grace. Read full review
Strange and uncompromisingly personal. It's also vivid and unforgettable. Read full review
The vagueness won't win Dumont new fans, but his enigmatic allegory of intertwined good and evil does linger in the mind. Read full review
Despite its pictorial intensity and the extremity of some of its scenes, the film proceeds in a mood of detachment, turning the suffering physical beings under its scrutiny into abstractions. Read full review
The problem with Outside Satan is that the filmmaker has remained faithful to expectations without enlivening them. It's a curious exercise unworthy of his expertise, but then he may realize as much. Read full review
The promise Dumont once showed has ossified into unholy shtick. Read full review
Be the first to rate this movie!


text:
"So long as the patient is experiencing a substantial or enduring state of suffering and incapacity, the patient has disease (dis-ease)."
According to this principle, ego-dystonic homosexuality should be reinstated into DSM. If not, why not?
BTW, this would not be something I advocate. It's a rhetorical question.
What you proposed is the definition of illness, not disease.
A sociopath enjoying a crime spree is not suffering or incapacitated, yet still has a mental disorder, so disease cannot be defined wholly by subjective suffering or incapacity.
"Moreover, those who argue that psychiatry medicalizes normality while simultaneously asserting that there is no clear demarcation between normality and abnormality effectively refute their own argument."
This is logically incorrect. Those asserting normality have the benefit of the null hypothesis, those theorizing disease do not.


text:
Programming with the Gambas Basic IDE
Distributing Programs
Programs you create with Gambas need the Gambas Runtime Engine on third-party machines. If you intend to distribute your software, the target system must have a run-time engine. Gambas provides an installation package wizard to help you set this up for your users. To launch the wizard, select Project | Make | Installation Package.
The wizard starts by prompting you for details on the author and a short description of the program. The version information and changelog are entered in Step 1. Gambas then creates installation packages for various distributions (Figure 7). As of this writing, the supported distributions are Fedora, Mandriva, Debian, Slackware, and Ubuntu. Packages created by the wizard can be installed and uninstalled by the distribution's native package management system.
Help and Support
Gambas has online Help with a command reference. Entries for commands and constants have examples that clarify usage. For those who prefer to learn a programming language by following examples, the IDE includes a number of ready-made projects that illustrate the use of various components.
To access the sample files, select File | Open examples…. The examples are sorted by group and are all very simple. In addition, the comments in the source code help budding developers follow the logic.
A number of sample programs available online [9] provide a good starting point for building your own creations. However, some of the programs are fairly ancient. The tutorial created by the developers [10] is also a useful place to start your Gambas programming career. It guides you step by step through the development environment's functions, with an introduction to critical programming techniques.
The Gambas wiki [11] includes installation HOWTOs, a directory of error messages, and an up-to-date command reference. The comprehensive and very readable wikibook [12] for Gambas only covers version 1 of the environment.
For the most part, the documentation lacks support on advanced programming topics, such as how to develop custom components or more complex database programs.
Gambas offers a sensible user interface and an easy-to-learn programming language that let you develop simple graphical applications with a very short learning curve. It includes comprehensive support for various database types and lets programmers quickly and easily build front ends for database applications.
The program is now more than stable enough for production use. Version 2.0 suffered from a number of bugs and crashed fairly frequently, but version 2.5 has removed these failings.
Right now, Gambas needs updated documentation to make it more comprehensive.
Although some useful tutorials are available on the web, you won't find much information on advanced programming techniques.
- HBasic: http://hbasic.sourceforge.net
- wxBasic: http://wxbasic.sourceforge.net
- KBasic: http://www.kbasic.org/
- Gambas: http://gambas.sourceforge.net
- Gtk+: http://www.gtk.org
- Qt: http://www.trolltech.no/qt
- Gambas binary packages: http://gambas.sourceforge.net/download.html
- Installation guides for Gambas: http://gambasdoc.org/help/install?view
- Gambasforge: http://www.gambasforge.net
- Gambas newcomer tutorial: http://gambas.sourceforge.net/start.html
- Gambas wiki: http://gambasdoc.org/help
- Gambas 1 wikibook: http://en.wikibooks.org/wiki/Gambas
« Previous 1 2
Read full article as PDF:
042-045_gambas.pdf (844.29 kB)Comments
Gambas IDE for Ubuntu
You can get the latest package of the Gambas IDE by typing the following commands in the terminal:$ mkdir -p ~/install/gambas
$ cd ~/install/gambas
$ svn checkout https://gambas.svn.sourcefo...oot/gambas/gambas/branches/2.0
$ cd 2.0 <a href="http://www.ubuntumanual.org...for-developers">Gambas IDE Ubuntu : Ubuntu Development Environment
Tag Cloud
New Mint Minted
Version 16 of the popular Linux desktop reveals new tools, edge-snapping, and performance improvements.
New Worm Attacks Linux Devices
Symantec says Linux-Darlioz burrows in through PHP.
Project Sputnik Gets a Boost
Dell renews its quest for the ultimate developer machine.
Sneaky New Linux Attack Discovered in the Wild
Innovative back door looks like normal SSH traffic.
CeBIT Call for Papers
One of CeBITs most successful forums opens the new year with a new name. The popular Open Source Forum continues in 2014 under the name Special Conference: Open Source. This year, the forum will be bigger and offer a wider range of possibilities for sponsors.
Linus Announces Linux Kernel 3.12
New release offers better graphics drivers and expands filesystem support.
Dark Alliance Reinvents Email Security
New mail protocol will shut out the NSA and prevent snooping on metadata.
DDos Attack Map Charts Denial of Service
A new web application helps users visualize distributed denial-of-service attacks.
Saucy Salamander Gets Legs
Ubuntu 13.10 takes a step toward convergence, with lots of mobility, but Mir only partly here.
Intel and Arduino Create Pi-Like System
Galileo board is targeted to embedded developers and educational institutions.


text:
- Connect with LRI:
- YouTube
- Change.org
Forum for Discovery 2010
Leading lupus scientists outlined results from the Institute's 10-year impact report, "Driving Discovery Through Innovation."
Panelists discussed translating basic research to therapies. Researchers described their pioneering lupus research that would not have occurred without the Institute's risk-taking strategies.
"The conference provides an outstanding opportunity for scientists to meet, collaborate, and share ideas. I came away with a laundry list of new areas to investigate in our lab."
– Steven Bensinger, PhD, UCLA
On the go?
Text INFO to 50555 and opt-in to receive breaking news about lupus on your mobile phone.
Message and Data Rates May Apply. Text STOP to 50555 to STOP. Text HELP to 50555 for HELP. Full Terms
- B Cells
- Biomarkers
- Cardiovascular System
- Cell Signaling
- Central Nervous System
- Dendritic Cells
- Environmental Triggers
- Gender Matters
- General Immune System Function
- Genetics
- Human Lupus Biology
- Kidney
- Lupus Pregnancy
- New to Lupus
- New Treatments
- Skin
- T Cells
- Target Identification
- Why the Lupus Immune System Reacts to Its Own DNA


text:
High Temperature Accelerometer Offers Reliable, Accurate Measurement
September 26, 2013 3:56 pm | by MDT Staff | Measurement Specialties, Inc. | CommentsMeasurement Specialties now offers a robust, DC-response accelerometer that operates in temperatures from -55°C to +170°C. The new MEMS-based 4604HT features an amplified output as well as critical dampening to a -80 dB/decade response attenuation for excellent high frequency signal suppression and improved measurement accuracy.
Zinc Selenide Plano-Convex Lenses with 8-12µm AR Coating
September 25, 2013 11:19 am | by MDT Staff | Edmund Optics | CommentsEdmund Optics (EO) has announced today that it has doubled it's offering of stock Zinc Selenide Plano-Convex (PCX) Lenses. These lenses are an ideal choice for high power laser applications, thermal imaging, FLIR, and medical systems.
Compact, Low-Voltage Power Supplies Suit Many Applications
September 25, 2013 11:09 am | by MDT Staff | Tdk - Lambda Americas | CommentsTDK Corporation has announced the extension of the TDK-Lambda GWS500 series power supplies with the addition of two low output voltage models. Combining the same high efficiency, high power density and low standby power characteristics as other models within the GWS500 series, the 5V 80A and 7.5V 67A models are well-suited for fitting into 1U enclosures.
Ultra-Durable Controlled Impedance Cable & Assemblies
September 25, 2013 11:03 am | by MDT Staff | Cicoil Corporation | CommentsCicoil has announced the introduction of its ultra-durable Controlled Impedance Cable. Unlike bulky round cables and non-flexible woven cables, the Cicoil deign can be utilized in applications requiring submersion in water, repetitive motion and exposure to harsh environments.
FPC Connectors Deliver up 2.5 Times Higher Retention Force
September 25, 2013 10:41 am | by MDT Staff | Hirose Electric Usa | CommentsHirose Electric has developed a 0.3 mm pitch (FPC) flexible printed circuit connector that supports high speed transmissions and provides high retention forces. The back flip style actuator utilizes dual-sided FPC and helps it to achieve the excellent impedance characteristics that allow it to be used for high speed transmissions...
Upgraded High Performance Multi-Pixel Photon Counter Detectors
September 24, 2013 4:08 pm | by MDT Staff | Hamamatsu Corp. | CommentsHamamatsu Photonics have introduced a completely updated range of Multi-Pixel Photon Counter (MPPC) detectors. Hamamatsu's already highly regarded MPPC technology has found uses in various applications from medical physics and high energy physics to general optical measurement applications.
External Power Supply Lines Available in 30-Watt or 50-Watt Configurations
September 24, 2013 3:57 pm | by MDT Staff | ICCNEXERGY | CommentsICCNexergy has announced the launch of its new 30-watt and 50-watt desktop power supply lines for both medical (MWA030, MWA050) and ITE/commercial (FWE030, FWE050) applications. These new power supply lines meet Level V efficiency standards and are available in both class I and class II designs.
True RMS Self-powered AC Voltmeter
September 24, 2013 2:25 pm | by MDT Staff | Murata Power Solutions | CommentsMurata has announced the DMR20-1-ACV "nanometer" self-powered four-digit bright LED voltmeter. This line powered AC voltmeter can measure the true RMS value of its input from 85 to 264 VAC to within 0.1 V resolution.
USB+CAN Development Kit for Microcontroller Development
September 24, 2013 2:13 pm | by MDT Staff | Texas Instruments Inc. | CommentsDesigning with Tiva C Series microcontrollers (MCUs) is now even easier with the new Tiva C Series TM4C123G USB+CAN Development Kit from Texas Instruments Incorporated (TI) (NASDAQ: TXN).
Inductive Angle Sensors Provide Accurate Valve Monitoring on Rotary Actuators
September 23, 2013 4:51 pm | by MDT Staff | Turck Inc. | CommentsTURCK has announced its new line of inductive angle sensors for rotary actuators. Operating with the inductive resonant circuit measuring principle, these inductive angle sensors deliver enhanced valve monitoring on rotary actuators. The sensors are designed with an innovative open face design...
Micro Diaphragm Pump for Small Portable Negative Pressure Wound Therapy Devices
September 23, 2013 4:07 pm | by MDT Staff | Parker Hannifin Corporation | CommentsA new micro diaphragm pump from the Precision Fluidics Division of Parker Hannifin Corporation is specifically designed for the needs of portable medical devices for advanced wound care. The Parker T2-05-IC micro diaphragm pump provides the negative pressure...
Extremely Non-magnetic Micro-D Connectors
September 23, 2013 2:46 pm | by MDT Staff | Axon Cable Inc. | CommentsSmall, robust and extremely non-magnetic. These are the qualities of the new micro-D connectors developed by Axon' Cable. These miniature connectors are designed for devices which rely on magnetism when operating.
Highly Reliable, Precision-Machined Double Row SMT Sockets
September 23, 2013 2:28 pm | by MDT Staff | Mill-Max Mfg. Corp. | CommentsThe new 406 series SMT socket strip from Mill-Max is ideal for socketing leaded IC devices on SMT boards and for low profile board stacking applications. The connector is dual row, .100" (2,54 mm) pitch, accepts standard IC leads and when used in combination with SMT or through-hole headers, provides a reliable interconnect solution.
Digital Pressure Sensors
September 20, 2013 5:29 pm | by MDT Staff | Honeywell Sensing And Control | CommentsHoneywell Sensing and Control's new Digital Pressure Sensors with CANopen, Model DPS, are rugged, all-welded, provide consistent performance in harsh environments, and can be used in a wide range of demanding applications like transportation, process control, factory automation, medical equipment systems, and aerospace test and research.
Angled M8 Connectors with Screw Clamp Termination
September 20, 2013 5:10 pm | by MDT Staff | Binder Usa | CommentsBinder-USA has announced a new angled M8 field-attachable connector with screw clamp termination. The screw clamp termination makes field-assembly simple by eliminating the requirements of special tooling.


text:
A teaspoon of the stuff might make your medicine go down, but exceeding your recommended sugar intake could lead to obesity, heart disease, and not-so-healthy eating habits. But how much sugar is sweet, and how much turns your health sour? For the first time ever, the American Heart Association (AHA) has released guidelines giving people an idea of what a healthy daily sugar intake really is.
Read More: What Sugar Does to Your Heart
The AHA statement, published in the journal Circulation, makes the point that added sugars, such as high-fructose corn syrup or ordinary table sugar added to sodas, breads, and other processed foods, are likely responsible for the increase in calorie consumption and the subsequent rise in obesity of the past few decades. Furthermore, people who have unhealthy sugar intake levels also consume lower levels of vital nutrients, such as zinc, iron, calcium, and vitamin A. And one study has suggested that too much sugar could raise blood pressure levels. The report also notes that over the past 30 years, we've consumed an average of 150 to 300 more calories per day than we used to, 50 percent of which come from beverages. And our physical activity levels remain unchanged, so those extra calories don't get burned off.
Read More: 7 Surprising Reasons to Give Up Sugar
Surveys have also found that the average American consumes around 22.2 teaspoons of added sugar every day. Is sugar toxic at those levels? Emerging studies suggest so. And according to the new guidelines, we should really be eating a fraction of that amount. The recommended sugar intake for adult women is 5 teaspoons (20 grams) of sugar per day, for adult men, it's 9 teaspoons (36 grams) daily, and for children, it's 3 teaspoons (12 grams) a day.
Not All Sugar Is Bad
Naturally occurring sugars in fruits, vegetables, low-fat dairy and whole grains don't need to be avoided, and make up part of a healthy diet, says lead author Rachel K. Johnson, PhD, MPH, RD, associate provost and professor of nutrition at the University of Vermont in Burlington. Even the occasional soda isn't a bad thing. "We're not saying that you should eliminate sugar from your diet or that you can't have sugar-sweetened foods," she says. But when you can't stay within the recommended sugar allowances, you need to make up for it with extra exercise. And rather than waste your sugar intake on sodas and other empty calories, she adds, "use it in a way that enhances the flavor and palatability of already nutritional foods like flavored yogurt or flavored milk."
Read More: The 5 Best, and 5 Worst, Sweeteners In Your Kitchen
Of course, knowing how much sugar you should be eating is completely different from calculating what you're actually eating. Daily intakes of added sugar aren't easy to estimate, says Johnson, as the Food and Drug Administration doesn't require that nutrition labels list the amount of naturally occurring sugars separate from the amounts of added sugars. The American Society of Nutrition's new Smart Choices Program, which launched this past summer, can help you to a certain extent. Products that qualify must get fewer than 25 percent of their calories from added sugar, but some products that qualify have as many as 17 grams per serving (nearly a full day's worth for women), and the nutrition labels still don't note whether those are naturally occurring or added.
The best way to cut added sugars out of your diet is to limit processed foods as much as possible, and satisfy your sweet tooth with fruit. Make a practice of this, and you won't need to spend so much time staring at food labels and counting sugar grams.
Published on: August 25, 2009
Updated on: November 14, 2013


text:
national arts in education week
September 9–15, 2012
In July 2010, the U.S. House of Representatives passed a resolution declaring the week following the second Sunday of September as Arts in Education Week.
Take the opportunity to draw attention to arts education in your school, and build momentum for a great remainder of the school year.
Ways to Celebrate Arts in Education Week
Arts Education Blog Salon
Americans for the Arts hosts this biannual event about arts education topics on ARTSblog. The blog salon features a collection of posts by arts and education leaders throughout the week. Follow the salon by using the arts education tag on ARTSblog. Join in the discussion by adding comments, sharing via social media, or chatting with us on Twitter on September 12, 2012 from 6-7PM Eastern, using the #artsed hashtag.
Arts Education Partnership Fall 2012 Forum
Arts Learning Without Borders will take place in Chattanooga, TN on September 13 and 14, 2012.
10 Ways to Support Arts Education
Download this article that outlines concrete actions to support arts education in your community. (PDF)
What You Can Do to Celebrate
Read this article by the Ohio Alliance for Arts Education, which lists 30 things anyone can do to celebrate Arts in Education week. (PDF)
- Take Action
Visit the Arts Action Fund to start a conversation about documenting the importance of arts education.
Public Service Announcement
To talk about the importance of music programs in schools, this 30-second commercial, created by Big & Tall Advertising, takes a humorous tone with a more controversial topic. Bullying isn't something to joke about, but in this instance it helped make a point: that all types of kids become more productive if they are involved in music.
Scott Kaplan, the writer of the ad, is a concerned parent of two musicians who wants to get the word out about this little discussed topic. Contact email@example.com for more information.


text:
Field trip to Exmouth
Date: 8th January 12
Time: 10:30AM - 4:00PM
Location: Exmouth seafront
Contact: Jenny Leathes ARPS
Phone: 01209211156
Cost: Free
Type: Other
Region: South West
The usual seasonal blow the cobwebs away after the Christmas period. Lunch will be taken in a local cafe or pub after exploring the seafront, beach, dunes or harbour areas.
Meet at the Car Park just past the old inshore RNLI station next to the old railway carriages, if you reach the new lifeboat station you have gone to far.


text:
The gradually-growing form of ChristopherSpottiswoode's ... (2YBQ)
Ontology Chemistry - a grand challenge project proposition (2YBR)
Preamble (2YBZ)
(hopefully to be rendered redundant before long.) (2YC3)
The project seriously presented here as a Grand Challenge candidate is a proposition of enormous intended impact. But a first glance may well leave it seeming mind-boggling in its ambition, ... or pretentiousness, ... or sheer folly. (2YC0)
A little further knowledge of it may (I imagine) leave you in a more seriously worried so completely dismissive state of mind: "It's all far too totalitarian for my liking!" (2YC1)
So one major objective in these pages is not only to convince you that the project is feasible, with the envisaged Ontolog Community-managed steps even within a practical Grand Challenge timeframe, but also to convey to what extent the project's targeted outcome should also embody, and even strongly reinforce and augment, all the major checks and balances against the rightly-feared human tendency. (2YC2)
A 3-step project as starting-point for discussion at this stage (2YC4)
1. The Ontolog Community thrashes out the issues as set out here (on the wiki for continual updating), maybe with one or more F2F workshops, and decides whether to proceed with the evolving plan. (By end 2011?) Then if so: (2YC5)
2. Further define and organize, then fund, mount, launch and execute the Grand Challenge. (Launch or some earlier clear stage at Ontology Summit 2012?) (2YCI)
The outcome would be a starter "Application Operating System" (AOS) able to function as qualitatively-better platform or environment for all Internet-based applications, and thereby to start bootstrapping the new ecosystem. (1 further year, with review at Ontology Summit 2013?) (You'll see how that could well be not out of the question, thanks to the Challenge product / AOS boot product's fully architecture-canonical design.) (2YC6)
3. The evolving and burgeoning ecosystem now launched into the Internet wild continues as a fully self-managed universal marketplace. (Onwards, with ever more variations of the AOS, always interoperable.) (2YC7)
The following sections will build on the areas listed in the "Matthew Lange 5x5 points" from this paragraph in an earlier post: http://ontolog.cim3.net/forum/ontolog-forum/2011-10/msg00160.html#nid06 (2YCG)
An outline of AOS, its requirements, and resulting ecosystem (2YC8)
... (many further details still coming!) (2YC9)
Key aspects of the proposed new architectural paradigm (2YCA)
(and its particular appropriateness as a focus of the Ontolog Community.) (2YCB)
... (many further details still coming!) (2YCC)
The wonderful - and attractive! - appropriateness as a Grand Challenge (2YCD)
... (many further details still coming!) (2YCE)
Some confidently foreseeable wider impacts (2YCF)
... (many further details still coming!) (2YBS)


text:
There are many things that can make you fell good in a hotel. Maybe the design is not in the top 3 for everyone. For me it is, and this one needs a change. The blue color present almost everywhere is definitely not the best nuance one can use in such a generous quantity. The building has a classic architecture... More
- Official Description (provided by the hotel):
- The Neoclassical architectural style façade uncovers a host of impressive, bright interiors. Select from the assortment of tastefully decorated, fully-equipped rooms then admire the stunning sights, from your private balcony. Appreciate calmness and serenity of the interior terrace, opened during the summer. Organize your businesses, or your company in this space of modern comfort. Whether you want a relaxing retreat or an activity break, options are multiple at this stunning property. ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Expedia, Booking.com, Hotels.com, Travelocity, Agoda and Priceline so you can book your Continental Forum Sibiu reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


text:
- Mobile site
- E-Newsletters
- News feed
- Find us on Twitter
Ilkley and Wharfedale news tweets
Peace events to be held in district (From Ilkley Gazette)
Get involved: send your pictures, video, news and views by texting IGNEWS to 80360, or email
Local news RSS Feed
Peace events to be held in district
4:10pm Tuesday 9th October 2012 in Local news
A district-wide season celebrating Bradford's peace heritage starts next week.
The Routes to Peace season takes place from March to July 2013, bringing together organisations aiming to engage people through a programme of events including exhibitions and peace work with young people.
Routes to Peace starts on Tuesday at the Peace Museum in Bradford from 5pm.
The event will be attended by local peacemakers and Olympic torch-bearers Brenda Thomson and Khalil Hussain and Bradford's young Peacemakers – peer educators, children and young people from the district's primary and secondary schools.
For more information, call (01274) 780241 or visit routestop eace.wordpress.com.


text:
VisitScotland uses cookies to enhance your experience on our website. By using our website you consent to our use of cookies. Please read our new privacy and cookies statement for more information.
Overview of Things to do
Overview of About Scotland
Overview of Accommodation
Overview of Scotland's Regions
Overview of Travel
Overview of Vacations
ST ANTHONYS BED & BREAKFAST, FORT WILLIAM Gill and Dave welcome you to St. Anthonys which is situated above Fort William, and commands spectacular views across Loch Linnhe to the Ardgour Hills beyond.
Note: Prices are a guide only and may change on a daily basis.
For public transport information to visit here from within Scotland, enter your postcode and visit date below.
For Accommodation and information, please call: 0845 859 1006 Monday to Friday 9am - 5pm Saturday and Sunday - closed
*Calls may be recorded
Alternatively please choose one of our other international websites:


text:
Please enter your login information below:
Enter your details here to be kept up to date with property news and alerts.
Make a Home on the Hillside with a Grimaud Property
Tuck yourself away in the heart of the Maures mountains when you purchase a property from the medieval town of Grimaud. Grimaud property is ideally situated near the infamous St Tropez and Sainte Maxime – some of the most beautiful and rich parts of the Côte d'Azur. Whether you are looking for a virtually traffic-free town or a property with its own berth, a Grimaud property boasts tranquillity, breathtaking Mediterranean views and an intimate ambience.
Browse our range of Grimaud property within this most sought after location for luxury French Riviera properties.
Find Your Sanctuary with Grimaud Property
Melt away your troubles with an idyllic retreat amongst this calm and picturesque town. Grimaud is a charming medieval perched village overlooking the glittering blue bay of the Golfe de Saint-Tropez. Fortified since the 11th Century, the medieval-style village has preserved its original charm with field stone houses and picturesque squares lined with cafes.
Purchase a property surrounded by history within this attractive village dominated by the striking ruins of the feudal castle. Grimaud property offers a superb location for those wanting to escape the frenzy of the French Riviera, whilst still having the excitement of St Tropez & St Maxime at your fingertips.
Just some of the many things on the doorstep of a Grimaud property include;
11th Century CastlePort GrimaudFour Miles West of St TropezLes Praries de la Mer CampsiteRomanesque ChurchWater Sports Facilities18 Hole Golf CourseForests of Pines & Oaks
Grimaud Property with Homehunts
HOMEHUNTS offers a daily updated property search displaying listings of luxury Grimaud property, Plan de la Tour properties and Garde Freinet property.
If you can't find your dream property for sale on the French Riviera, contact the Home Hunts multi-lingual team today who will be happy to help with your luxury French property enquiry.
Our portfolio of luxury property for sale in the South of France is unmatched, featuring a high class selection of luxury properties in Grimaud.
© HOMEHUNTS 2013 All rights reserved
Chateaux and estates for sale
Hotels for sale
Vineyards for sale
Waterfront properties for sale
Investment properties for sale
Golf properties for sale


text:
2 Meetup Groups match "Shadowrun" near Brighton, CO
Welcome to the Denver RPG meet-up Group! We are a diverse group of gamers and GMs who delight in playing a wide variety of games in various editions from Shadowrun to D&D to GURPS and anything in between that our players are willing to play! The primary objective for this meetup is to act as a "matchmaker" between GMs and players, or smaller groups seeking additional members, or for starting up whole new groups. New players are always welcome, even if you have never played an RPG before, pleas …
A group for LGB gamers to find gaming groups with like minded indavidules. Dungeons and Dragons, New and Old World of Darkness, Shadowrun, and any other Rpg.
Get an alert email when new Meetup Groups like this start near you.
You'll get advice, help finding members, and tools to make running a Meetup Group easier.


text:
- Publisher: Sony Online Entertainment
- Release Date: Nov 20, 2012
- Also On: PlayStation 4
User Score
Mixed or average reviews- based on 1045 Ratings
User score distribution:
Positive: 697 out of 1045
Mixed: 120 out of 1045
Negative: 228 out of 1045
Review this game
Please sign in or create an account before writing a review.
Check Spelling
- User score
- Most active
- By date
- Most helpful
- Most Clicked
Jan 29, 2013You play for 4 hours to capture or defend a base, next day its lost again. yes the battles are epic but it all seems so pointless. Air dominates, spawn camping gets frustrating. pay 2 win scheme. it was fun for a week but i'll be moving on to games with actual progress
Nov 23, 2012Bad attempt to make awesome multiplayer. First this game have one of uglier graphics this year, but this is not crucial for multiplayer game anyways. But, game fail in all other aspects. Glitchy, bad spawn points ruining the action, bad shooting are only few of bad thins this game bring to the table. Only good thing is free to play because if they charge for this would be really cheating.
Jan 7, 2013
Jan 29, 2013
Feb 2, 2013Oh god when will the bugs end? I've put up with it since release, but I'm done now. After the most recent game update the game has become unplayable for me. I highly regret the money I've spent on this game as things continue to grow worse. In large battles I'm lucky to get 4-10 fps when a month ago I was getting 30-40. I have a Phenom II 960T and a 6870. It's ridiculous.
Jun 5, 2013Not many shooters can keep me hooked like Planetside 2 can. The combination of addicting and compelling gameplay and teamwork with the responsiveness of the dev team make this a game that will last
Nov 22, 2012
Jan 6, 2013
Nov 27, 2012
Nov 30, 2012
Jan 24, 2013
Feb 2, 2013
Jan 17, 2013My rig can play all the F2P games with no issues, except for this game. The FPS is so bad I could not be bothered to finish the training level. Optimization for this game is typical for many PC titles very poor as usual.
Nov 29, 2012
Nov 29, 2012
Aug 20, 2013
Jan 9, 2013
Jan 13, 2013
Jan 26, 2013John Smedley failed with SWG sinking it into the ground. Within one year he took a game with 1,000,000 copies sold down to nearly 10,000 subscribers still playing, then lied to the public on his failures. Why anyone let him be in charge of Planetside 2 is beyond me..
Apr 1, 2013
Dec 19, 2012
Nov 23, 2012i have to give props to sony online entertainment for actually trying to make a triple-A MMOFPS title AND doing a great job at it!!!!!! most FPS games that come out now have a story mode and an online mode, while i believe that it should be one or the other (story mode OR online mode). if you love online FPS, you're gonna love planetside 2!!!!!!
Dec 11, 2012Planetside 2, some mix Massive shooter with RPG (?), in my opinion idea this game is great and underdone.
On the + : Big maps, vehicles, graphic (not bad textures for that big game maps), re-spawn protect (!),
On the - : Fight and flight too much arcade style, where is RPG system (?), after 40 min. is boring -
Jan 16, 2013The game is only free to play if your intentions are dying to spawn campers and the constant feel of losing. The game ultimately feels like a massive grind-fest if you do not give into their high priced bonuses and items.
Jan 21, 2013Hackers. Hackers everywhere. Now the new hack added to all the regular ones is to somehow mess with the collision in the game to send you flying from the spawn half way across a continent to fall and die. This game is riddled with bugs and hackers everywhere.
Jan 26, 2013The graphics are decent, the game play isn't bad. But the weapon physics are dreadful, paying players get everything immediately and you're either dropped right into battle (which for new joiners is a dreadful notion), or you're in the middle of frickin' no where with nothing around you and you can't jump on a vehicle because you don't have the necessary XP to activate one. Bull. ****
Mar 16, 2013
Mar 9, 2013
Dec 2, 2012Sorry but having to pay $7 for a single weapon for a single class that doesn't even look unique but is only a complete copy design-wise just isn't acceptable.
Nov 21, 2012
Jan 29, 2013
Feb 15, 2013I would like this game. If it wasn't so much pay to win. Say, you want a gun so you play for 5 hours straight and then you get it (only if you play good) BUT if you have the money, you buy expensive credits and get the gun instantly. Game should be called Pay 2 Winside 2
Dec 4, 2012
Jan 7, 2013
Feb 17, 2013
Dec 1, 2012
Nov 21, 2012Great game that will continue to get better! Love it...while there are a few bugs that need some ironing out, this game has a bright future ahead of itself.
May 22, 2013
Nov 21, 2012
Jan 16, 2013
Nov 29, 2012
Jun 24, 2013
Nov 28, 2012
Feb 19, 2013This game is free to play as a spectator, If you want to help your team or be anything other than cannon fodder then you have to spend money. I was looking for a game to play that I wouldn't mind paying some money for a couple extras, but, being defenseless and building my char around my credit card, terrible.
Dec 2, 2012
Nov 21, 2012Unoptimized beta. Bugs.
Don't get me wrong, every software has bugs but how can you release a game in beta stage? I sank into the ground 3 times for less than 1 hour. Just an example of what kind of bugs you will come across.
I like the idea of the game I'm looking forward to play it but please, Sony... Before you release a game make sure doesn't have at least trivial bugs. -
Nov 27, 2012
Nov 29, 2012The game is phenomenal. Its restored my faith in MMOs. There's nothing quite like shooting at a rational target for a change over NPC mobs with deterministic AIs. Player driven content is the future.
Dec 3, 2012
Jul 9, 2013
Nov 21, 2012
Nov 22, 2012
Nov 23, 2012
Nov 27, 2012
Nov 27, 2012
Nov 28, 2012
Nov 29, 2012Huge scale battles and absolutely no game crashes or bugs. Huge scale battles and absolutely no game crashes or bugs. Huge scale battles and absolutely no game crashes or bugs. Huge scale battles and absolutely no game crashes or bugs. Huge scale battles and absolutely no game crashes or bugs. Huge scale battles and absolutely no game crashes or bugs.
Nov 29, 2012
Dec 1, 2012
Jun 5, 2013I have been playing this game since launch and it has gotten much better since then! I have increased my score for the game because the devs have added so much to it since launch and because they continue to add new content every week.
Jan 5, 2013Its Great that there're a lot of people to play with and to communicate with, the gun play isnt reall skill based and isnt any fun really to play over long grinds. Plus the Beginning sucks
Jan 29, 2013
Jan 22, 2013At best, I would say "meh." I think the price is about right though.....I would have been upset if I paid for it. The graphics are alright, but the action is chaotic at times, but that's only when you find it. I am not sure exactly what it was, but I kept thinking about the fact that I had a perfectly good BF3 game in the next room....
Feb 4, 2013
Mar 9, 2013
Jun 5, 2013
Jun 5, 2013Planetside 2 is very harsh for new players because there's barely any tutorial BUT as soon as you understand it its awesome you like big fights but most fps don't deliver that scale? Try Planetside! you easily get 100+ player fights and sometimes around 300 on each team fighting in one base against each other
Jun 5, 2013
Oct 6, 2013
Jan 9, 2013Impossibly huge in scope and scale. I can't believe that it's a free game. The fact that it's an MMO astounds me. Nowhere do I see the slightest gameplay sacrifices because of it, even though the game can support literally thousands of players in a server. This game is a gameplay gem, and a technical masterpiece. There just isn't anything else like it.
Dec 8, 2012
Dec 1, 2012Planetside 2 falls short of Planetside 1 in about every category, but it's still a lot of fun and the best recent shooter out there. Be advised it's poorly optimized at the moment with some netcode issues, but hopefully when those are ironed out it will be fun for everyone.
Their customer service team is responsive and fast. Haven't run into any obvious hackers yet. -
Mar 3, 2013If you like being frustrated and annoyed, play this game. If your sadomasochistic, spend money on this game. What I find most frustrating is the huge potential of this game, SOE just doesn't have what it takes to make this game into what it could have been, it's a shame really. I have been playing and waiting for it to deliver since the game first came out, but I have given up on PS2 and SOE.
Dec 1, 2012
Dec 6, 2012
Jun 21, 2013
Nov 25, 2012
Dec 3, 2012
Nov 26, 2012
Nov 28, 2012It's fun. But be warned: you need a RIG to play this. On low settings with a good PC you'll still be at 20-30 fps. If your PC is outdated don't bother. The minimum requirements for this are not even close. ...As far as the game, It's just TDM. There's nothing really epic about it. --It'll feel epic at first. Give it a week though.
Oct 14, 2013Could have been a good game but the pay to win structure of the game ruins it. Don't bother trying to earn anything by actually playing the game unless you're willing to blow a week or more just to get a gun. I found the more I played it the more futile any efforts towards progressing became. Frustrating and not fun.
Feb 14, 2013
Feb 19, 2013Instructions: none. Tutorial: none. Upgrades after 4 hours of gameplay unnoticeable. Constant prompting to buy cert points via cash shop: annoying. Hacks: prominent. Maps poorly designed: windows everywhere in buildings. Support classes: easy targets. Spawn in middle of rocket blast: instantly dead. So many glaring issues: will not pay to play.
Jan 14, 2013
Jun 29, 2013
Jan 7, 2013
Nov 25, 2012This game is amazing capturing immersion and epic sense of war no matter what gamer you owe it to yourself to download it. It can make you rage but the pros far out ways the cons
Nov 25, 2012
Dec 2, 2012
Dec 6, 2012amazing game! best fun you can ever have :)
been playing it for 2 days , very addictive, great graphics, wonderful game play through out.
best online experience I've ever had -
Dec 7, 2012
Dec 12, 2012Incredible. A few bugs here and there but will be ironed out carving this game into a 10/10 no doubt. It's quite difficult to get into and is very confusing at the beginning but stick with it and you'll be fighting like the best in no time. The scale of this game really is like nothing you've seen before and the wide variety of roles will keep me playing for a long time.
Jan 14, 2013
Jan 20, 2013Frustrating game too big maps and too less players. You can run 2h and you don't see any enemies.
Graphic is nice but not on high-level. Is there few bugs. Planet Side 2 is next game pay for win not play for free. -
Jan 21, 2013
Jan 27, 2013
May 26, 2013
Nov 10, 2013
Mar 3, 2013
Mar 25, 2013Planetside 2 is one of those games that drops you in the battlefield without any experience or knowledge over what to do and how to do it. You're often wondering where the action is going on, and when it's there you're powerless. I had to give it a three because, for a free to play game, it looks stunning, but it's a dead hamster hidden in a beautiful box.
May 10, 2013The shooter fundamentals are all there. The visuals are great but the progression just doesn't seem to deliver any payoff for players outside of the hardcore. It's not quite as much of a shameless cash grab as something out of Zynga, but it definitely sours the experience.
Feb 19, 2013Planetside 2 is a good free-to-play, strong functional and very funny, which does not envy anything to the founders of the first-person shooter genre.
Feb 4, 2013It might look overly complicated, but PlanetSide 2 is nothing more than your average class-based, objective-oriented competitive FPS. What makes it stand apart from other F2P games (aside from the huge servers, of course) is the co-operation factor with other players. [February 2013]


text:
By Susan Koomar
It's time for the annual warning from PennDOT to watch out for deer that are on the move for mating season.
Deer are most active between dusk and dawn in October and November. Plus, it's getting dark earlier so it's more difficult to see deer when you are driving.
More than 3,000 crashes involving deer were reported in 2010 in Pennsylvania, resulting in more than 600 injuries and eight fatalities, PennDOT statistics show.
PennDOT offers these deer safety tips:
- Watch for the telltale glow of a deer's eyes in the dark.
- Deer travel in groups and in single file so, if you see one, be prepared for more to follow.
- If you see a deer, slow down, tap your brakes to warn others and sound your horn to move the deer.
- Deer fixate on headlights - flashing them may cause the deer to move out of harm's way.


text:
We welcome your comments, and hope to host meaningful discussions about the Alameda County Medical Center and the community it serves. Please follow these guidelines:
Comments will never be edited, but we do reserve the right to remove posts that do not follow these guidelines. Your email is never shared.
Name *
Email *


text:
Klippel-Trenaunay-Weber Syndrome (cont.)Medical Author:
David Perlstein, MD, MBA, FAAP
David Perlstein, MD, MBA, FAAPDr. Perlstein received his Medical Degree from the University of Cincinnati and then completed his internship and residency in pediatrics at The New York Hospital, Cornell medical Center in New York City. After serving an additional year as Chief Pediatric Resident, he worked as a private practitioner and then was appointed Director of Ambulatory Pediatrics at St. Barnabas Hospital in the Bronx. Medical Editor:
William C. Shiel Jr., MD, FACP, FACR
William C. Shiel Jr., MD, FACP, FACRDr. Shiel received a Bachelor of Science degree with honors from the University of Notre Dame. There he was involved in research in radiation biology and received the Huisking Scholarship. After graduating from St. Louis University School of Medicine, he completed his Internal Medicine residency and Rheumatology fellowship at the University of California, Irvine. He is board-certified in Internal Medicine and Rheumatology. In this Article
Are there other abnormalities in Klippel-Trènaunay-Weber syndrome?Although the triad of "port-wine stain, varicosities, and asymmetric limb hypertrophy," is the consistent clinical centerpiece of Klippel-Trènaunay-Weber, there are often other less frequent abnormalities found in those affected by the syndrome. These may include other limb or digit abnormalities such as:
In addition to limb abnormalities, there are some other common features, including:
Eye problems may include glaucoma and cataracts. Finally, any of the vascular anomalies can affect the internal organs including the intestinal and urinary tract systems. These may be at risk for spontaneous bleeding, and it is important to evaluate any individual with evidence of superficial abdominal lesions. Patient CommentsViewers share their comments
Klippel-Trenaunay-Weber Syndrome - Personal Experience
Question: Please describe your experience with Klippel-Trenaunay-Weber syndrome.
Klippel-Trenaunay-Weber Syndrome - Prognosis
Question: What is the prognosis for Klippel-Trenaunay-Weber syndrome in you or a relative? How do you manage your symptoms?


text:
My dermatologist said it was fine if i wanted to load up on anti inflammatorys to decrease the redness of acne. I have been doing it for 2 days and it has worked well. Is this healthy to do long term? I guess that is the plan until something better comes along.
Works better than antibiotics, thats for sure.


text:
The coding period has ended. I have submitted my final evaluation and now waiting for the final results to be announced. This post is a wrap up of what happened through the summer and the current status of the project I was working on.
The project I chose, Profile in the Cloud (PiCl) is a fairly new project which is under heavy development. I joined the project in the prototyping stage. When the GSoC started, there was no stable backend for storage or authorization (none exist even now ). There were prototypical servers called picl-keyserver and picl-server for authorization and storage respectively. We initially started building the client on top of picl-keyserver. I used the picl-contacts-dev branch to push the code. After, completing the keyserver implementation, I started researching on possible ways to merge contacts on the client.
As we proceeded, the back-end changed several times. Currently, the project I proposed is around 70-80% complete. It gets an assertion from the Persona idp and interacts with the sync 1.1 server. It also has a contacts wrapper which reads contacts and will ultimately be used to merge as well. I currently, do not have a working merge algorithm in the code but it won't take much time time to plug in the code as we had already done a bit of research back in the 3rd & 4th week. Also, the functionality of automatic sync is currently not integrated due to lack of time.
Most of the work got delayed/could not complete because of a lot of moving parts in the back-end. I will continue working on the project even after GSoC and will hopefully be able to create quality production level code in a couple of months with the help from Jed and the rest of the identity team.


text:
Car Prices
Compare Cars New & Used
CPO Certified Cars
Credit Center
Free Dealer Price Quote
Finance Center
Local Listings
Vehicle History
Classic Cars
Classic Car Values
All Classic Cars - Manufacturers (A-Z)
Vehicle History
Motorcycle Values
Compare All Powersports
Boat Values
All Boats - Manufacturers (A-Z)
RV Values
RV Dealer Price Quotes
All RVs - Manufacturers (A-Z)
Manufactured Homes
Home Value Report
Home Definitions
Buy CONNECT
Product Store
Change Make
Change Year & Model
Select Trim
Used 2001 Toyota Sequoia Values
The 2001 Toyota Sequoia isn't afraid to get dirty, and yet it's refined. Basically, it's everything a full-size SUV should be and more. With quality construction, durable materials, a firm, quiet ride and its third-row seats that offer capacity for up to eight passengers, the Sequoia does well hauling people and cargo and driving on rough terrain, in all kinds of weather. Offered in two trims – the SR5 and the Limited – the Sequoia features a 240 horsepower 4.7-liter gas-powered V8 with your choice of two or four wheel drive. Standard features include air, cruise and keyless entry.
Select a used 2001 Toyota Sequoia trim level
2001 Toyota Sequoia Utility 4D Limited 2WD
2001 Toyota Sequoia Utility 4D Limited 4WD
2001 Toyota Sequoia Utility 4D SR5 2WD
2001 Toyota Sequoia Utility 4D SR5 4WD
Back to all 2001 Toyota Cars, Trucks, and SUVs
Please Enter Your ZIP Code
Your ZIP Code is used to provide you with information specific to your location.


text:
- Mobile site
- E-Newsletters
- News feed
- Find us on Twitter
Follow us on Twitter
- Find us on Facebook
Croydon Guardian
Like us on Facebook
Central Avenue, Welling, Kent, DA16 - 2 bed - £169,950 - Robinson Jackson - Welling
Contact us: Got a photo? Text SLPICS to 80360, click to upload your story, or call 020 8722 6350
Property details
Central Avenue, Welling, Kent, DA16 £169,950
Sold STC
Marketed by:
Robinson Jackson - Welling
Phone the agent:
020 8303 5213
Send me homes like this by email daily / weekly
Property details
Bedrooms: 2
5 brand new converted apartments situated conveniently for Welling Mainline Station and local bus routes. All with new 125 year lease
Fully Fitted Kitchens
Built in Oven & Hob
Washer Dryer
All Flooring Included
Gas Fired Central Heating
Voice Door Entry System
Double Glazed Windows
TV/Sky/FM Communal Dish
Telephone Points
Communal Roof Terrace
Other Features
Each property at Station House Apartments will be finished to a high internal specification and include all white goods and flooring as standard so all you need to do is move in!
Local information for this property
Adamsrill Primary School
Albion Primary School
Aldborough E-ACT Free School
Aldersbrook Primary School
Alderwood Primary School
Alexander McLeod Primary School
Alexandra Junior School
Alfred Salter Primary School
All Saints CofE Junior School
All Saints' Church of England Primary School
Allen Edwards Primary School
Applegarth Junior School
Applegarth School
Archbishop Sumner Church of England Primary School
Ardleigh Green Junior School
ARK Globe Academy
Arnhem Wharf Primary School
Ashmead Primary School
Ashmole Primary School
Athelney Primary School
Avanti Court Primary School
Aveley Primary School
Avenue Primary School
Baden-Powell School
Balgowan Primary School
Bangabandhu Primary School
Bannockburn Primary School
Barclay Primary School
Baring Primary School
Barley Lane Primary School
Barn Croft Primary School
Barnehurst Junior (Foundation) School
Barrington Primary School
Beacon Hill School
Beam Primary School
Bean Primary School
Beckmead School
Becontree Primary School
Bedonwell Junior School
Beecroft Garden Primary
Bellenden Primary School
Belmont Park School
Belmont Primary School
Belvedere Junior School
Ben Jonson Primary School
Benhurst Primary School
Benson Primary and Nursery School
Benthal Primary School
Benyon Primary School
Beormund Primary School
Berger Primary School
Bessemer Grange Primary School
Beulah Junior School
Bickley Primary School
Bigland Green Primary School
Birkbeck Primary School
Bishop John Robinson Church of England Primary School
Bishop Ridley Church of England VA Primary School
Blenheim Primary School and Nursery
Blue Gate Fields Junior School
Bonner Primary School
Bonnygate Primary School
Boutcher Church of England Primary School
Boxgrove Primary School
Brady Primary School
Brampton Primary School
Brampton Primary School
Branfil Primary School
Brent Knoll School
Brindishe Green School
Brindishe Lee School
Britannia Village Primary School
Broadmead Primary School
Brook Community Primary School
Brooklands Primary School
Brunswick Park Primary School
Burbage School
Burnt Ash Primary School
Burnt Oak Junior School
Bursted Wood Primary School
Burwood School
Buxton School
Bygrove Primary School
Calverton Primary School
Camelot Primary School
Canary Wharf College
Canon Barnett Primary School
Cardwell Primary School
Carpenters Primary School
Castilion Primary School
Castle Hill Primary School
Castlecombe Primary School
Cayley Primary School
Central Park Primary School
Cet Primary School Tower Hamlets
Chadwell Primary School
Chafford Hundred Primary School
Charles Dickens Primary School
Charlotte Sharman Primary School
Charlton Manor Primary School
Compare all 803
Abbs Cross Academy and Arts College
Addey and Stanhope School
All Saints Catholic School and Technology College
Alleyn's School
Archbishop Tenison's School
ARK Globe Academy
Azhar Academy
Babington House School
Bacon's College
Barking Abbey School, A Specialist Sports and Humanities College
Barking Riverside School
Beacon Hill School
Beal High School
Beatrice Tate School
Beaverwood School for Girls
Beckmead School
Beis Trana Girls' School
Bellerbys College
Belmont Park School
Bethnal Green Technology College
Beths Grammar School
Bexley Grammar School
Bexleyheath Academy
Bishop Challoner Catholic Collegiate Boys School
Bishop Challoner Catholic Collegiate Girls School
Bishop Challoner School
Bishop Justus CofE School
Bishop Thomas Grant Catholic Secondary School
Blackfen School for Girls
Blackheath Bluecoat Church of England School
Blackheath High School
Bonus Pastor Catholic College
Bow School of Maths and Computing
Brampton Manor Academy
Bredinghurst School
Brent Knoll School
BRIT School for Performing Arts and Technology
Bromley High School
Bullers Wood School
Burwood School
Buxton School
Cardinal Pole Roman Catholic School
Caterham High School
Cavendish School
Central Foundation Boys' School
Central Foundation Girls' School
Chadwell Heath Academy
Chafford Hundred Campus Business and Enterprise College
Charlton School
Chislehurst and Sidcup Grammar School
City of London Academy (Southwark)
City of London Academy - Islington
City of London School
City of London School for Girls
Clapton Girls' Academy
Cleeve Park School
Colfes School
Coloma Convent Girls' School
Conisborough College
Connaught School for Girls
Coopers Technology College
Corbets Tey School
Corelli College
Cressey College
Crown Woods College
Cumberland School
Dagenham Park CofE School
Darrick Wood School
Dartford Grammar School
Dartford Grammar School for Girls
Dartford Science & Technology College
Darul Hadis Latifiah
Darul Uloom London
Deptford Green School
Drumbeat School and ASD Services
Dulwich College
Dunraven School
East London Independent Special School
Eastbrook Comprehensive School
Eastbury Comprehensive School
Eastlea Community School
Edenham High School
Education Links
Elm Court School
Eltham College
Eltham Hill Technology College for Girls
Emerson Park School
Erith Secondary School
Evelyn Grace Academy
Farringtons School
Forest Gate Community School
Forest Hill School
Forest School
Furness School
Gaynes School
George Green's School
George Mitchell School
Glebe School
Grays Convent High School
Compare all 297
Contact the agent
Local information for this property
Local Advertisers


text:
Potholes to be Repaired
Governor McDonnell has directed VDOT to pull out all the stops to repair potholes in the highway that he says are both dangerous and expensive.
The harsh winter has brought thousands of them.
Caldwell: Potholes may form very quickly on any road.
VDOT's Jeff Caldwell says they're dangerous.
Palmer: If the ball joint fails the wheels will fall flat to the ground.
Ian Palmer at Dunkum's Auto.
Palmer: If the tie rod was to break you would have no steering on that wheel. A bent rim, what you don't want is the car coming off the rim while you are travelling down the highway.
And, break an alloy wheel?
Beninghove: Anywhere between $400 and $1200.
Fishburne: For one wheel?
Beninghove: Yessir.
Frank Beninghove at Wheel Wizard in Southside fixes them.
Beninghove: I've worked through Saturday, Sunday and everything trying to get those things fixed.
VDOT says it'll spend 45 million, or whatever, to get them fixed.
Caldwell: We are committed to patching potholes.
If you find one… report it to VirginiaDOT.org, and you'll know when.
Beninghove: At seventy miles an hour and you hit a pothole, yep, you'll go, Man! And it's all over then.
Charles Fishburne, WCVE News.


text:
Valentin Alsina and Damian Boss star in FIXED AND FUCKED an incredible series of scenes featuring hairy, uncut, muscle-bound bears fucking like only real men fuck… hard!
The film has minimal dialogue which is good, because we just want to get to the intense man on man action that will leave everyone spent and drained of cum.
Bruno Fox has his way with Yohann Banks in scene two, followed by Riley Coxx giving it to a greedy Sam Bishop.
Yohann Banks is back and this time, in scene four, he is going to get his hole wrecked by built hunk Antonio Garcia…
You do not want to miss out on this flick full of fur, fun and fucking!
Watch Fixed and Fucked by Alphamales! Starring Antonio Garcia, Bruno Fox, Damian Boss, Riley Coxx, Sam Bishop, Valentin Alsina, Yohann Banks.


text:
Trial record 1 of 17 for:
Open Studies | "Hyperlipoproteinemia Type II"
Efficacy and Tolerability of Anacetrapib Added to Ongoing Lipid-Lowering Therapy in Adult Participants With Homozygous Familial Hypercholesterolemia (HoFH) (MK-0859-042 AM2)
This study is currently recruiting participants.
Verified November 2013 by Merck Sharp & Dohme Corp.
Merck Sharp & Dohme Corp.
Information provided by (Responsible Party):
Merck Sharp & Dohme Corp.
ClinicalTrials.gov Identifier:
First received: April 24, 2013
Last updated: November 8, 2013
Last verified: November 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This study will evaluate the safety and effect of anacetrapib on low-density lipoprotein-cholesterol (LDL-C) when added to ongoing lipid-lowering therapy. The primary hypothesis is that treatment with anacetrapib 100 mg for 12 weeks will lower LDL-C to a greater extent than treatment with placebo.
Condition | Intervention | Phase |
Hyperlipoproteinemia Type II Homozygous Familial Hypercholesterolemia |
Drug: Anacetrapib Drug: Placebo |
Phase 3 |
Study Type: | Interventional |
Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Treatment |
Official Title: | A Worldwide, Multicenter, Double-Blind, Randomized, Placebo-Controlled, 12-Week Study to Assess the Efficacy and Tolerability of Anacetrapib When Added to Ongoing Lipid-Lowering Therapy in Adult Patients With Homozygous Familial Hypercholesterolemia (HoFH) |
Resource links provided by NLM:
Genetics Home Reference related topics:
Chanarin-Dorfman syndrome
cholesteryl ester storage disease
U.S. FDA Resources
Further study details as provided by Merck Sharp & Dohme Corp.:
Primary Outcome Measures:
- Percent change from Baseline in Low-density Lipoprotein-Cholesterol (LDL-C) using beta-quantification method [ Time Frame: Baseline and Week 12 ] [ Designated as safety issue: No ]
- Number of Participants with Alanine Transaminase (ALT) or Aspartate Aminotransferase (AST) Consecutive Elevations ≥3x Upper Limit of Normal (ULN) [ Time Frame: 12 weeks ] [ Designated as safety issue: Yes ]
- Number of Participants with Creatine Phosphokinase Elevations ≥10xULN with or without Muscle Symptoms [ Time Frame: 12 weeks ] [ Designated as safety issue: Yes ]
- Number of Participants with Sodium, Chloride, or Bicarbonate Elevations >ULN or Potassium Levels <Lower Limit of Normal (LLN) [ Time Frame: 12 weeks ] [ Designated as safety issue: Yes ]
- Number of Participants with Pre-specified Adjudicated Cardiovascular Serious Adverse Events or Death from Any Cause [ Time Frame: 12 weeks ] [ Designated as safety issue: Yes ]
- Number of Participants with Significant Increase in Blood Pressure [ Time Frame: 12 weeks ] [ Designated as safety issue: Yes ]
Secondary Outcome Measures:
- Percent Change from Baseline in High-density Lipoprotein-cholesterol (HDL-C) [ Time Frame: Baseline and Week 12 ] [ Designated as safety issue: No ]
- Percent Change from Baseline in Apolipoprotein A-I (apoA-I) [ Time Frame: Baseline and Week 12 ] [ Designated as safety issue: No ]
Estimated Enrollment: | 45 |
Study Start Date: | June 2013 |
Estimated Study Completion Date: | March 2015 |
Estimated Primary Completion Date: | March 2015 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Anacetrapib
Participants receive anacetrapib 100 mg orally once daily for 12 weeks.
Drug: Anacetrapib
100 mg tablet orally, once daily for 12 weeks
Other Name: MK-0859
Placebo Comparator: Placebo
Participants receive placebo orally once daily for 12 weeks.
Drug: Placebo
Placebo for anacetrapib orally, once daily for 12 weeks
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Diagnosed with HoFH by genotyping
- If female, cannot be of reproductive potential
- Have been stabilized on statin monotherapy or statin therapy coadministered
with other lipid medications for at least 6 weeks
Exclusion Criteria:
- Severe chronic heart failure defined by New York Heart Association
(NYHA) Classes III or IV
- Uncontrolled cardiac arrhythmias, myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary arterial by-pass graft (CABG), unstable angina or stroke within 3 months prior to Visit 1 or has planned procedures scheduled within first 12 weeks of study
- Uncontrolled endocrine or metabolic disease known to influence serum
lipids or lipoproteins
- Active or chronic hepatobiliary or gall bladder disease
- History of ileal bypass, gastric bypass, or other significant condition
associated with malabsorption
- Human immunodeficiency virus (HIV) positive
- Donated blood products or has had phlebotomy of >300 mL within 8 weeks or intends to donate 250_mL of blood products or receive blood products within the projected duration of the study
- Taking medications that are potent inhibitors or inducers of cytochrome P450 3A4 (CYP3A4), including but not limited to cyclosporine, systemic itraconazole or ketoconazole, erythromycin, clarithromycin, or telithromycin, nefazodone, protease inhibitors, carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, St John's wort) or has discontinued treatment <3 weeks prior. Consumption of >1 liter of grapefruit juice per day is also prohibited.
- Currently participating or has participated in a study with an investigational compound or device within 3 months
- Consume more than 2 alcoholic drinks per day
- Receiving treatment with systemic corticosteroids or systemic anabolic agents
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01841684
Contact: Toll Free Number | 1-888-577-8839 |
United States, Florida | |
Call for information (Site 0477) | Recruiting |
Winter Park, Florida, United States, 32792 | |
Contact 407-849-0484 email@example.com | |
United States, Wisconsin | |
Call for Information (Investigative Site 0475) | Recruiting |
Milkwaukee, Wisconsin, United States, 53226 | |
Canada, Quebec | |
Merck Canada | Recruiting |
Kirkland, Quebec, Canada, H9H 3L1 | |
Contact: Medical Information Centre / Centre de l'information médicale de Merck Canada 514-428-8600 / 1-800-567-2594 | |
Israel | |
Merck Sharo & Dohme Co. Ltd. | Recruiting |
Hod Hasharon, Israel | |
Contact: Ofer Sharon 972 9 9539310 | |
Italy | |
MSD Italia S.r.l. | Recruiting |
Rome, Italy | |
Contact: Patrizia Nardini 39 06 361911 | |
Norway | |
MSD Norge A/S | Recruiting |
Drammen, Norway | |
Contact: Henning Hoyte 47 32 20 75 20 |
Sponsors and Collaborators
Merck Sharp & Dohme Corp.
More Information
No publications provided
Keywords provided by Merck Sharp & Dohme Corp.:
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on December 11, 2013
No publications provided
Responsible Party: | Merck Sharp & Dohme Corp. |
ClinicalTrials.gov Identifier: | NCT01841684 History of Changes |
Other Study ID Numbers: | 0859-042, 2012-002434-37 |
Study First Received: | April 24, 2013 |
Last Updated: | November 8, 2013 |
Health Authority: | United States: Food and Drug Administration |
Keywords provided by Merck Sharp & Dohme Corp.:
HoFH |
Additional relevant MeSH terms:
Hyperlipoproteinemia Type II Hypercholesterolemia Hyperlipoproteinemias Hyperlipidemias Dyslipidemias Lipid Metabolism Disorders Metabolic Diseases Lipid Metabolism, Inborn Errors Metabolism, Inborn Errors |
Genetic Diseases, Inborn Oxazolidinones Anti-Infective Agents Therapeutic Uses Pharmacologic Actions Protein Synthesis Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action |
ClinicalTrials.gov processed this record on December 11, 2013


text: Prospective parents are invited to visit St. John's and tour the Pre-K through 8th grade classrooms. Come and see first hand why our National Blue Ribbon and S.T.E.M, (Science, Technology, Engineering, and Math) school offers the best Catholic school education in the area. Please take a moment to visit our website at www.sjrcs.org to learn about our outstanding academic programs and state-of-the-art facility, our students' accomplishments, and the Christ-centered atmosphere on campus. You will see why we are proud to celebrate 180 years of academic excellence in Frederick County.


text:
(Source: behindmypalette)
(Source: behindmypalette)
(Source: thenicolemethod, via carolineeex3)
(via joanna-nicole)
(Source: fortheloveofpretty.net, via dianacqin)
(Source: flickr.com, via missasbury)
21 things jesus wants you to know … right now
Here's what Jesus wants you to know:
You are my beloved. (Eph. 5:1)
I knew you before you were born. As my hands formed you, I whispered purpose into your bones. I can't not love you. (Ps. 139:1-6)
I love you beyond human reason—even at your very worst, steeped in sin. (Rom. 5:8)
My love is contrary to all you know of "love." I Love you "even though" and "deeper still." My love reaches, pursues, remains. (Ps. 36:5)
My Love for you won't walk out, fail, or ever come to an end. (Deut. 31:8)
No matter what you've heard or what you've come to believe, there's nothing that can separate you from my Love. (Rom. 8:38-39)
I am not like people. So please—don't put human words in my mouth or apply human behaviors to my character. You will miss me altogether. (Isaiah 55:8)
I've never ignored you. I've been here all along. Protecting. Loving. Waiting. (Ps. 56:8)
Your love of _____ (sin) isn't worth eternity. I will break your chains. I will give you the desires of your heart. (Jn. 8:32, Ps. 37:4)
Please forgive some of my followers. People—even Christian people—will fail you. You live in a fallen land, where no one is perfect and all need My grace. Put your faith and trust in Me alone. (Psalm 146:3)
There's no sin I will not forgive. You are the "whosoever believes in me" whom I will give eternal life … if you believe. (John 3:16)
As resourceful and brilliant as you are, you cannot save yourself. It's by God's grace and faith in Me alone that you are saved. (Eph 2:8-9)
I understand your pain and heartbreak. And my heart breaks with you. (Is. 53:3)
There's nowhere you can go where my Love won't find you. (Psalm 139:7-8)
The shame and guilt weighs you down has been taken care of on the cross. Your bill has been zeroed out. (John 3:16)
The addictions. The pride. The selfishness. The hate. The lust. The jealousy. The critical spirit. The greed. I can heal it. All of it. You can start fresh. Today. (Rom. 8:1-4)
I will forgive you. But only if you ask. And I care more about the "ask" than I do about the sin. (Acts 3:19)
I will not force you to do or be anything. I want a relationship with you more than I want to rule over you. (Jeremiah 31:3)
I will forgive your sin and I will forget it. That's right—completely erase it from my mind. No replays, no record. Gone. (Ps. 103:12)
It's never too late to turn your life around. I came to give second chances. (Luke 23:42-43)
I love you. Let's talk. (Jer. 29:13)
(Source: vanilla-diamond, via dianacqin)


text:
ANNALS OF POLITICS about Ernesto (Che) Guevara, Latin American revolutionary, who was for a time, Minister of Economics in Cuba. He was killed in Bolivia recently where he was trying to provoke a revolution. This is an account of the writer's meeting with Guevara, whom he first saw in Aug., 1961, at Punta del Este in Uruguay. The Economic & Finance Ministers of all the American republics had assembled there in response to Pres. Kennedy's proposal for a hemisphere conference to draft the basic charter of a new Alliance for Progress. G. led the Cuban delegation & Mr. Goodwin was a member of the U.S. delegation. At the meeting the two delegations had no direct contact. Tells about a secret meeting, at a party, bet. Guevara and the writer, which lasted 3 hours. Guevara spoke of a possible modus vivendi bet. the U.S. & Cuba, among other things Writer reported all to Pres. Kennedy, & it was put into a memo which went to the President's foreign policy advisers. An accomodation with Cuba, at that time, it was felt, would undermine certain S. American nations friendly to the U.S. News of the secret meeting leaked out - tells about that and about Guevara's end. His manner of dying yields, as nothing in his life ever did, possibilities of legendary immortality. He may well become the hero of radical revolution in Latin America.
- Keywords
- ";
- Viva Zapata;";
- Cuba;
- Guevara, Che (Ernesto);
- South America;
- Zapata, Emiliano;
- "
Richard N. Goodwin, Annals of Politics, "A FOOTNOTE.," The New Yorker, May 25, 1968, p. 93
Newyorker.com has a complete archive of The New Yorker, back to 1925. The complete archive is available to subscribers in the digital edition. If you subscribe to the magazine, register now to get access. If you don't, subscribe now.
You can also buy online access to a single issue. Individual back issues are available for sale through our customer-service department, at 1-800-825-2510.
All articles published before May, 2008, can be found in "The Complete New Yorker," which is available for purchase on hard drive and DVD. Most New Yorker articles published since December, 2000, are available through Nexis.
To search for New Yorker cartoons and covers, visit the Cartoon Bank.


text:
My daughter and I stayed 1 night to visit Fort Leonard Wood the next day. We arrived on Friday evening, around 9pm. It was easy to find with a couple other hotels nearby and a Waffle House just before you get to the hotel driveway. The parking lot was not very busy when we arrived. The front desk clerk was... More
- Also Known As:
- Motel 6 Saint Robert
- Motel Six Saint Robert
- Saint Robert Motel Six
- Saint Robert Motel 6
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Orbitz, Cheap Tickets and Travelocity so you can book your Motel 6 St. Robert reservations with confidence. We help millions of travellers each month to find the perfect hotel for both holiday and business trips, always with the best discounts and special offers.