text:
Saturday, February 27, 2010
Cochrane Menstrual Disorders and Subfertility Group: Clomiphene citrate for unexplained subfertility in women
Plain English Summary: "Clomiphene citrate for unexplained subfertility in women Clomiphene citrate is a fertility drug that can increase the number of eggs released for possible fertilisation. It is used by women who do not ovulate regularly and by some who do but still have not become pregnant. Clomiphene citrate does not appear to increase the chance of pregnancy in women who ovulate regularly but have failed to conceive after more than a year of unprotected intercourse and so are considered to be subfertile. An associated risk of treatment with clomiphene citrate is a 10% chance of multiple pregnancy. The results of this review of trials should be used with caution due to the heterogeneity between some of the studies."
add your opinions
Management of drainage for malignant ascites in gynaecological cancer
Authors' conclusions:
Since no relevant studies were identified, we are unable to make recommendations regarding the management of drains for malignant ascites in women with gynaecological cancer. Large, multi-centre RCTs are required to evaluate the efficacy and safety of the management of ascitic drains when in situ and their impact on QOL.
Friday, February 26, 2010
Some people just won't take death for an answer
e-patients blog: "We often talk here about empowered patients' struggles to get – or even create – the care they need. Usually we're talking about it in a medical sense. But as far too many people know, sometimes there are other obstacles. Laurie Todd is, to me, an outstanding example of someone who wouldn't take death for an answer – neither from doctors....."
CK7, CK20, CDX2 and MUC2 Immunohistochemical Staining Used To Distinguish Metastatic Colorectal Carcinoma Involving Ovary from Primary Ovarian Mucinous Adenocarcinoma
Objective: Colorectal adenocarcinoma, the most common tumor that metastasizes to the ovary, is often difficult to distinguish from primary ovarian mucinous adenocarcinoma (POMA). Obtaining the correct diagnosis is difficult but crucial to treatment and prognosis.
new book: Editor's comment (Jason Marsh) "The Compassionate Instinct": Uncovering the New Science of Human Goodness
"Taken together, this research challenges some long-held notions about human nature, revealing that the good in us is just as intrinsic to our species as the bad. Empathy, gratitude, compassion, altruism, fairness, trust, and cooperation, once thought to be aberrations from the tooth-and-claw natural order of things, are actually core features of primate evolution.
For too long a view of humans has prevailed that assumes we are wired to compete, to act aggressively, to pursue unbridled self-interest. These are no doubt facets of human nature, but they represent only half of the story.
"The Compassionate Instinct" reveals another story, one that places goodness at the center of human nature. The book doesn't deny the existence of the violence and selfishness we see in the world around us. But it offers scientific evidence that another world is possible."
press release: Precision Therapeutics- Chemosensitivity/Resistance Assay Included as Part of the NCCN Principles of Chemotherapy - MarketWatch
Note: as per just published NCCN guidelines 2/2010 Ovarian Cancer section (read the guidelines for further explanation) http://www.nccn.org
Laboratory Product News: Manhattan Scientifics Acquires Exclusive Rights to Nanomedicine Technology for Early Cancer Detection and Treatment
"Manhattan Scientifics Inc. (OTCBB: MHTX), a nanomedicine technology transfer and commercialization pioneer, today announced completion of its agreement to acquire all commercial rights to the body of work of nuclear physicist Edward R. Flynn, PhD and his company, Senior Scientific LLC. The breakthrough technology focuses on the emerging field of nanomedicine, with an emphasis on the early detection and localization of cancer and other diseases, and providing image-guided therapy for treatment."Financial details of the agreement were not disclosed. Early detection of cancer can be critical to effective treatment. For example,
Thursday, February 25, 2010
Genomics - Funding 2010 CDC and NIH New Genomics Funding Opportunity Announcement
Systematic evidence reviews will examine the validity and utility of various health-related genomic tests (e.g., DNA, RNA, and proteomic tests; family health history tools; other health-related genomic services), including information on contextual factors and ethical, legal, and social issues. These evidence reviews will be conducted using the methods developed by the Evaluation of Genomic Applications in Practice and Prevention (EGAPP™) Working GroupExternal Web Site Icon and CDC. Some of these reviews will be used by the EGAPP™ Working Group to make recommendation statements on the use of the genomic tests and other services.
The center will collaborate with CDC to develop brief evidence summaries (topic briefs) on the validity and utility of selected genomic applications and related issues.
Evidence reviews and topic briefs, along with recommendation statements and other resources, will be made publicly available in an online knowledge repository. This repository is being developed by NOPHG, NIH's National Cancer InstituteExternal Web Site Icon, and the National Center for Biotechnology InformationExternal Web Site Icon of the National Library of MedicineExternal Web Site Icon and will be released later this year.
EvidenceUpdates: Comparative effectiveness of MRI in breast cancer (COMICE) trial: a randomised controlled trial
Note: includes commentaries
The European Medicines Agency is in Overall Agreement with OncoGenex Pharmaceuticals' Development Plan for OGX-011 - financial news
"Since increased clusterin production is observed in many human cancers, including prostate, non-small cell lung, breast, ovarian, bladder, renal, pancreatic, anaplastic large cell lymphoma and colon cancers and melanoma, OGX-011 may have broad market potential to treat many cancer indications and disease stages."
updated (annual) February 2010: NCCN Clinical Practice Guidelines in Oncology
Note: the NCCN website requires registration/password but is free. It is an excellent resource for ovarian cancer(s) as well as genetic syndrome guidelines.
Page 4 indicates changes over prior guidelines.
add your opinions
Genentech Announces Positive Results of Avastin Phase III Study in Women with Advanced Ovarian Cancer
In the three-arm study, known as Gynecologic Oncology Group (GOG) 0218, women with newly diagnosed advanced ovarian cancer who already had surgery to remove as much of the tumor as possible were randomized to receive one of the following:
-- Arm 1: Placebo in combination with carboplatin and paclitaxel chemotherapy followed by placebo alone, for a total of up to 15 months of therapy
-- Arm 2: Avastin in combination with carboplatin and paclitaxel chemotherapy followed by placebo alone, for a total of up to 15 months of therapy
-- Arm 3: Avastin in combination with carboplatin and paclitaxel chemotherapy followed by the maintenance use of Avastin alone, for a total of up to 15 months of therapy.
The study showed that women who continued maintenance use of Avastin alone, after receiving Avastin in combination with chemotherapy (Arm 3), lived longer without the disease worsening compared to those who received chemotherapy alone. Women who received Avastin in combination with chemotherapy, but did not continue maintenance use of Avastin alone (Arm 2), did not live longer without the disease worsening compared to chemotherapy alone.
Ontario, Canada: Hospitals: Public consultations needed - Welland Tribune - Ontario, CA
"It's up to a lobby group to bring democracy to discussions about changes to Ontario's hospitals.
That's because the provincial government refuses to do so, said Ontario Health Coalition executive director Natalie Mehra. Despite repeated requests to the Ministry of Health, asking that its public Rural and Northern Health Care Panel hold public consultations, Mehra said the government has "refused to hold public consultations."
She said the government's panel will only be consulting with select organizations including Ontario Hospital Association, the Ontario Medical Association, Registered Nurses Association of Ontario and an emergency medical service organization.
"There's not a single patient group, no municipality, no seniors group, or advocacy groups, or public interest groups, nobody," she said in an interview Tuesday....."
Avastin performs in ovarian cancer trial - news item
Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary.
"Eighteen pregnancies (nine spontaneous) were observed in 14 patients."
add your opinions
serous borderline
Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways.
"These data suggest that accumulated alterations of p27(Kip1)-interacting proteins may accelerate the development of CCAs regardless of their carcinogenetic pathways, but that tumor cells in the CCAF-associated pathway appear to show slower cell-cycle progression than those in the endometriosis-associated pathway, possibly accounting for the distinct clinicopathological features of the two CCA subtypes."
full access: DNA Methylation Profiles of Ovarian Epithelial Carcinoma Tumors and Cell Lines
Table 1
Histology and clinical
characteristics of primary ovarian tumors. (serous, endometrioid, clear cell - CA125 levels, menopausal status,patient age)
Epithelial ovarian carcinoma is a significant cause of
cancer mortality in women worldwide and in the United States. Epithelial
ovarian cancer comprises several histological subtypes, each with
distinct clinical and molecular characteristics. The natural history of
this heterogeneous disease, including the cell types of origin, is
poorly understood.
add your opinions
clear cell
ovarian cancer
Occult ovarian cancers identified at risk-reducing salpingo-oophorectomy in a prospective cohort of BRCA1/2 mutation carriers.
"An unacceptably high proportion of pathologic examinations did not adequately examine ovaries and fallopian tubes obtained at RRSO."
add your opinions
risk reducing surgery
Wednesday, February 24, 2010
2009 Safety of Bevacizumab in Advanced Ovarian and Müllerian Cancers: A Review: Bevacizumab (Avastin) and Ovarian Cancer
"To date, several investigators (Table 1) have explored bevacizumab as a single agent or in combination with metronomic chemotherapy in the management of advanced ovarian cancer. All studies to date with bevacizumab as a single agent or in combination with chemotherapy have shown promising responses...."
abstract: Combined oral cyclophosphamide and bevacizumab in heavily pre-treated ovarian cancer (Spain)
Conclusions: Combined bevacizumab and metronomic oral cyclophosphamide is a safe and effective regimen for heavily pre-treated ovarian cancer patients. Further research is needed on predictive factors to screen for those patients who will benefit from anti-angiogenic therapy.
add your opinions
2008 Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chic
Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia.
Bevacizumab and Low-Dose Cyclophosphamide in Treating Patients With Recurrent Ovarian Epithelial or Primary Peritoneal Cancer - Full Text View - ClinicalTrials.gov
Bevacizumab and Low-Dose Cyclophosphamide in Treating Patients With Recurrent Ovarian Epithelial or Primary Peritoneal Cancer
This study has been completed.
First Received: November 4, 2003 Last Updated: February 6, 2009
Sponsor: California Cancer Consortium
Collaborator: National Cancer Institute (NCI)
Information provided by: National Cancer Institute (NCI)
ClinicalTrials.gov Identifier: NCT00072566
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Cancer and the Family: The Silent Words of Truth -- JCO The Art of Oncology series
INCONCLUSIVE THOUGHTS: One of the aims of psycho-oncology is to explore, clarify, and accept different realities that are alluded to in the unspoken words of the family narrative, while also eliciting family stories of survival, adjustment, mutuality, belief, and hope. The psycho-oncologist is trained to understand the language of the patient and family members in their subjective appraisals of health and illness and then to encourage them to share their truths about being understood, heard, supported, and emboldened or discredited and stigmatized.
Ephraim McDowell - Wikipedia encyclopedia Ephraim McDowell (November 11, 1771 – June 25, 1830) was an American physician. He was the first to success
Ephraim McDowell (November 11, 1771 – June 25, 1830) was an American physician. He was the first to successfully remove an ovarian tumor.
Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer - abstract
Conclusion: Pertuzumab may add activity to gemcitabine for the treatment of platinum-resistant ovarian cancer. Low HER3 mRNA expression may predict pertuzumab clinical benefit and be a valuable prognostic marker.
add your opinions
JCO - Relationship Between Plasma Estradiol Levels and Estrogen-Responsive Gene Expression in Estrogen Receptor-Positive Breast Cancer in Postmenopausal Women UK/US study
Purpose To determine whether plasma estradiol (E2) levels are related to gene expression in estrogen receptor (ER)–positive breast cancers in postmenopausal women.
add your opinions
cancer genetics risks
Editorial: Whither HER2-Related Therapeutics? (breast cancer) -- Journal of Clinical Oncology
Note: references to solid tumours
"Evidence suggests that most solid tumors, regardless of their type, cannot grow beyond approximately 1 mm3 until they establish a blood supply by inducing new blood vessels from existing host capillaries, called tumor-induced angiogenesis......It follows then that tumor cells with low HER3 mRNA are more likely to respond to pertuzumab, given that these are the cells where the pathway is activated. We would conjecture that this signature does not apply exclusively in ovarian cancer, but may also be found in other solid tumors, such as non–HER2-positive breast, colorectal, and so on."
add your opinions
solid tumors
Prospective Multicenter Cohort Study to Refine Management Recommendations for Women at Elevated Familial Risk of Breast Cancer: The EVA Trial.
CONCLUSION: In women at elevated familial risk, quality-assured MRI screening shifts the distribution of screen-detected breast cancers toward the preinvasive stage. In women undergoing quality-assured MRI annually, neither mammography, nor annual or half-yearly ultrasound or CBE will add to the cancer yield achieved by MRI alone.
Surgery protocols reviewed at Windsor hospitals
A nightmare!
The Patient Factor: What Are Your Health Care Dollars Buying? | thepatientfactor.com
"Asking Canadians if they are getting value for their money when it comes to spending on health care is like asking a blind person if they can see better when the room light is turned on or off...."
The Patient Factor: (Canada) Blowing the Whistle on Patient Safety: Why Patients Need to Speak Out
"Patient safety is a hot topic in Canada and one that often leaves our politicians scrambling to maintain some semblance of action. They do so by creating more federal, provincial and territorial agencies and programs. Many of these government-funded initiatives are set-up as independent (arm's length) non-profit organizations. Perhaps the biggest endeavour to date is the creation of the Canadian Patient Safety Institute (CPSI)...."
add your opinions
patient safety
Long-term endometrial effects in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES)—a randomised controlled trial of exemestane versus continued tamoxifen after 2–3 years tamoxifen
full access:
Conclusion: Switching from tamoxifen to exemestane significantly reverses endometrial thickening associated with continued tamoxifen.
free access: Impact of Medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial - Australia
Unfortunately, most research evaluating Qigong has suffered from a lack of appropriate randomization and utilization of control groups. Studies have also tended to focus on limited numbers of biological and physical outcomes.
Drugmakers Join Forces to Improve Cancer Research - Press Release/news
INDIANAPOLIS, WHITEHOUSE STATION, N.J. & NEW YORK--Eli Lilly and Company, Merck (also known as Merck Sharp & Dohme (MSD) outside the USA and Canada), and Pfizer Inc. today announced the formation of the Asian Cancer Research Group, Inc., (ACRG), an independent, not-for-profit company established to accelerate research and ultimately improve treatment for patients affected with the most commonly-diagnosed cancers in Asia.
Intraperitoneal Paclitaxel as Consolidation Treatment in Ovarian Cancer Patients: A Case Control Study
Conclusion: Weekly IP consolidation chemotherapy with paclitaxel 60 mg/mq is well tolerated and, in this experience, a prolongation of progression-free survival was observed.
Tuesday, February 23, 2010
Financial news: HealthLinx Ltd launches ovarian cancer OvPlex™ test into UK market
HealthLinx (ASX: HTX) has reported that UK distribution partner Intus Healthcare is targeting a significant share of the potential 750,000 annual ovarian cancer diagnostic tests undertaken in the UK with the product launch of OvPlex™ on 25 February 2010.
The company obtained European Certification for OvPlex™ paving the way to market and sell the product within the European community.
EvidenceUpdates: rTMS for suppressing neuropathic pain: a meta-analysis
add your opinions
Safety profile of new anticancer drugs; Expert Opinion on Drug Safety - abstract (solid tumors)
Take home message: The emergence of new targeted anticancer therapies promises more efficient and less toxic therapies. Generally, they are well tolerated, toxicities are commonly mild to moderate and can be handled rapidly. However, if most of these adverse events are manageable, life threatening and fatal complications can still occur.
Toxicity of sorafenib: clinical and molecular aspects; Expert Opinion on Drug Safety - abstract
Take home message: Although not life-threatening, toxicity of sorafenib can severely impact the physical, psychological and social well-being of patients. The management of this unusual toxicity highlights the particular need of new pluridisciplinarities linking oncologist, cardiologist and dermatologist
Drug interactions with antiretrovirals and warfarin; Expert Opinion on Drug Safety - abstract
Importance of the field: Antiretroviral therapy exhibits significant potential to alter the metabolism of other medications. Warfarin is widely used for the management of clotting disorders and is prone to drug–drug interactions that can result in subtherapeutic anticoagulation or over-anticoagulation. (warfarin, HIV, antiretroviral, drug interaction, protease inhibitor (PI), non-nucleoside reverse-transcriptase inhibitor (NNRTI), cytochrome P450 (CYP450), CYP2C9)
CLINICAL TRIALS IN CANADA Optimizing Patient Participation in a Global Market April 29 - 30, 2010 Montréal
Note: the conference fees
NCI Chemotherapy-induced Peripheral Neuropathy
"For preventing the onset of CIPN, the committee recommended further clinical testing of intravenous calcium and magnesium, which reduced CIPN symptoms by approximately half compared with a placebo in one trial
Avastin fails stomach-cancer trial - FiercePharma
"Data on Avastin use in ovarian cancer, expected sometime in the first half of this year."
Ovarian cancer diagnoses drop slightly
Note: prophylatic surgeries??
"Dr Zorbas said the figure had remained "fairly stable" for years and the lower level could represent the start of a new plateau, though the reason for the small drop was not yet clear......."The number of women diagnosed with ovarian cancer is expected to increase, and that's because the population is increasing and we have an increasingly ageing population," Dr Zorbas told AAP."
Total Laparoscopic Hysterectomy - ESGO
Coronary heart disease risk profile in women who underwent salpingo-oophorectomy to prevent hereditary breast ovarian cancer.
CONCLUSIONS: Self-selection of women seeking risk-reducing salpingo-oophorectomy, changes in lifestyle after surgery, and survival bias may explain that the women who underwent risk-reducing salpingo-oophorectomy had a more favorable coronary heart disease risk profile compared with the controls. Longitudinal studies are needed to further clarify the associations observed in this cross-sectional study.
Ovarian intestinal type mucinous borderline tumors: are we ready for a nomenclature change?
Note: mucinous is not specific to ovarian cancer but found in other tumour sites and without expert pathology can be confused with mucinous gastrointestinal tumours
"At a National Cancer Institute-sponsored workshop it was proposed that the borderline category of ovarian intestinal-type mucinous tumors (OInMTs) could be eliminated if the apparent benign behavior of these tumors could be confirmed..."
Randomized phase II trial of paclitaxel plus carboplatin therapy versus irinotecan plus cisplatin therapy as first-line chemotherapy for clear cell ad
Randomized phase II trial of paclitaxel plus carboplatin therapy versus irinotecan plus cisplatin therapy as first-line chemotherapy for clear cell adenocarcinoma of the ovary: a JGOG study CONCLUSIONS: A phase III randomized trial is required to elucidate the effectiveness of CPT-P combination chemotherapy for CCC
Final Agenda: Health 2.0 Europe conference (note: ACOR)
Patients and Online Communities - The advancement and popularity of patient communities online is an international phenomenon. We'll be examining communities in different cultures, languages and context, and see what impact they have on care delivery in different countries–and what the internationalization of information means for patients and doctors.
The patient perspective from:
- Roberto Ascione, PagineMediche.it Italy
- Gilles Frydman, ACOR america
- Ben Heywood, PatientsLikeMe america
- Neil Bacon, iWantGreatCare UK
- Christian Angele, imedo Germany
add your opinions
Monday, February 22, 2010
Risk of cardiac ischemia and arterial thromboembolic events with the angiogenesis inhibitor Bevacizumab in cancer patients: A meta-analysis of randomized controlled trials
add your opinions
blood clots
Sunday, February 21, 2010
Clinical Presentation of Endometrioid Epithelial Ovarian Cancer with Concurrent Endometriosis: A Multicenter Retrospective Study — Cancer Epidemiology, Biomarkers & Prevention
Conclusions: In this large series of patients with EEOC, the main presenting symptoms were pelvic pain followed by gastrointestinal symptoms, palpable mass, abdominal distension, vaginal bleeding, and newly developed or exacerbated dysmenorrhea and dyspareunia. Dyspareunia and dysmenorrhea were more frequently detected in patients with endometriosis. Normal CA-125 levels cannot be applied as a marker to exclude EEOC, particularly at the early stages. Cancer Epidemiol Biomarkers Prev; 19(2); 398–404
add your opinions
Your Doc Is In: North American Menopause Society Issues Guidelines on Hormone Therapy
Note: The actual guidelines will be published in the March/April issue of the Journal of the North American Menopause Society
Saturday, February 20, 2010
full access 2008: Systematic Review and Meta-analysis of Ovarian Cancers: Estimation of Microsatellite-High Frequency and Characterization of Mismatch Repair Deficient Tumor Histology
Translational Relevance:
This systematic review and meta-analysis estimates the frequency of high-level microsatellite instability (MSI-H) in unselected ovarian cancers as 12%, suggesting that defects in the mismatch repair (MMR) pathway account for a relatively large proportion of ovarian cancers. In the era of personalized medicine, MSI-H status may provide valuable etiologic and diagnostic information, which may eventually be of prognostic and therapeutic utility, as seen in MSI-H colorectal cancers.
The results of this meta-analysis also reveal an overrepresentation of nonserous histologies in MMR-deficient tumors. The clinical relevance of these findings is that they may increase clinical awareness of MMR-deficient tumors; such awareness may aid in the identification of this subtype of tumors, having potential implications for medical management.
European Medicines Agency (EMA): the Agency takes a further step in its interaction with patients and consumers | A global voice for patients
add your opinions
cancer patients genetics breast colorectal ovarian health
New Joint Outpatient Chemotherapy Administration Standards - Cancer Journal for Clinicians
The guidelines were created largely in response to recent studies that have examined reports of chemotherapy administration errors among outpatients, and to reports of an increased risk of errors with the administration of new oral chemotherapeutics.
add your opinions
Difficulty Accepting a Terminal Prognosis Linked with Depression, Anxiety, and Suffering - A Cancer Journal for Clinicians
Dissenting Opinion:
"Not all clinicians agree with the foregoing interpretations of these findings. "I've certainly seen people who denied dying up to their last breath and somehow never accepted it," Dr. Holland tells CA. "Were they more upset? I'm not sure."
She cautioned against allowing the findings by Dr. Thompson and colleagues to set a tone in which nonaccepting patients are viewed as dysfunctional."
add your opinions
terminal prognosis
full access: Feb 19, 2010 Can primary optimal cytoreduction be predicted in advanced epithelial ovarian cancer preoperatively?
Note: study of 41 women
add your opinions
fertility sparing surgery
ovarian cancer
Q&A: Harvard's Steven Skates Describes Using Clinical Assays for Longitudinal Proteomics Research | ProteoMonitor | Proteomics | GenomeWeb
"Skates is involved in a number of longitudinal studies honing in on early detection for ovarian cancer. In proteomics, such studies are still uncommon.
The three best-known studies that have incorporated proteomics are the Framingham Heart Study, the Busselton Health Study, and the UK Collaborative Trial of Ovarian Cancer Screening, of which Skates is a member."
Friday, February 19, 2010
PLoS Genetics: Use of DNA–Damaging Agents and RNA Pooling to Assess Expression Profiles Associated with BRCA1 and BRCA2 Mutation Status in Familial Breast Cancer Patients
definition: heterogeneous - the quality of being diverse and not comparable in kind
full access:
"A large number of rare sequence variants of unknown clinical significance have been identified in the breast cancer susceptibility genes, BRCA1 and BRCA2. Laboratory
methods to identify which of these variants are mutations would have utility for counseling and clinical decision making when identified in patients with a family history of
breast cancer."
add your opinions
cancer genetics risks
variants unknown significance
clinical trial search - new trials 2/01/2010-2/19/2010 - solid tumors phase 11-111
Search terms: solid tumors | Adult | Phase II III IV | has safety issue outcome measures | received from 02/01/2010 to 02/19/2010 - 2
Search of: ovarian cancer | received from 02/01/2010 to 02/19/2010 - List Results - ClinicalTrials.gov
Search terms: ovarian cancer, received between the dates of 02/01/2010 to 02/19/2010 - 8 results
California limits appointment wait times - - ModernMedicine
add your opinions
wait times
Thursday, February 18, 2010
Correspondence/Reply: Central Institutional Review Board–Facilitated Review Metrics Omit Critical Components
Central Institutional Review Board–Facilitated Review Metrics Omit Critical Components
Michael S. Katz, Mary L. Smith
Patient Representative Committee, Eastern Cooperative Oncology Group, Philadelphia, PA
To the Editor:
"As cancer survivors and patient advocates, we must take issue with calculations of the impact of the central institutional review board (CIRB) on local institutional review board (IRB) protocol review times and societal costs by Wagner et al.1 The authors' definitions of these metrics omit critical components......Thus, the net impact on IRB review times, which determine how quickly a protocol can move from National Cancer Institute approval to putting patients on-study are actually slower by 66 to 76 days than a stand-alone local review. The suggestion, therefore, that there are "benefits of a more predictable and faster approval process" is not accurate.""
2) CORRESPONDENCE - Reply to M.S. Katz et al
"Recent internal data from National Cancer Institute show that these changes have decreased the length of CIRB review, defined as application receipt to approval, from a median of 95.5 days in 2008 to 45 days for the six trials using the new processes."Author's Reply to Correspondence: Endocrine Effects of Aromatase Inhibitors Journal of Clinical Oncology
" It is somehow astonishing that after approximately 15 years from the first clinical article on anastrozole, exemestane, and letrozole, we still have insufficient or weak knowledge of some of the consequences of their long-term use."
add your opinions
adverse effects
aromatase inhibitors
Patient Opinion - NHS (UK) website
Your story can change the NHS * Tell people what happened * See what others are saying * Find out how patients are changing the NHS
Quest, Vermillion 'On Track' to Launch OVA1 in March | GenomeWeb
"OVA1 generates a numerical score based on five immunoassays that is intended to help physicians determine the likelihood of malignancy in women with pelvic mass for whom surgery is planned."
add your opinions
fertility sparing surgery
pre test
Integrative Oncology: Gerson Regimen
add your opinions
integrative medicine
HDAC Inhibitors in Cancer Care - Cancer Network
"What is more promising about this study was the utility in all of the cancers studied (ovarian, cervical, breast, testicular, and lung), demonstrating that combining HDAC inhibitors with other therapies may be clinically useful in multiple types of malignancies."
US Oncology picks up Cure magazine - Medical Marketing and Media
Cure magazine is located on the web at www.curetoday.com
Tumour Microenvironment The 'low oxygen' environment of solid tumours is leading to a new class of therapies and Measuring Tumour Hypoxia and Tumour Metabolism
Tumour Microenvironment The 'low oxygen' environment of solid tumours is leading to a new class of therapies and Measuring Tumour Hypoxia and Tumour Metabolism
Muslim women and medical students in the clinical encounter Medical Education
Medical Education 2010: 44 : 306–315
"Context Increasingly, male medical students report being refused by female patients, particularly in obstetrics and gynaecology, which is impacting on recruitment into the discipline. However, little has been documented in terms of Muslim patients and medical students in the clinical consultation."
Burnout and engagement among resident doctors in the Netherlands: a national study.
Conclusions: "As more than a fifth of the medical residents who responded could be diagnosed as suffering from burnout, we conclude that this problem needs addressing in the Dutch health care system, especially given that a relationship was proven between burnout and suboptimal patient care."
Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer
"Abstract: The chromosome 8q24 region (specifically, 8q24.21.a) is known to harbor variants associated with risk of breast, colorectal, prostate, and bladder cancers. In 2008, variants rs10505477 and rs6983267 in this region were associated with increased risk of invasive ovarian cancer (p < 0.01); however, three subsequent ovarian cancer reports of 8q24 variants were null.........These results indicate that the SNPs studied here are not related to risk of this gynecologic malignancy and that the site-specific nature of 8q24.21.a associations may not include ovarian cancer."
Comment regarding Pelvic Exams while under Anesthesia
My comment: While Lynn's abstract is interesting, it is noteworthy again that these are not new issues as per the included references. I would disagree that further research is required. A root cause analysis is not going to add anything further to what has already been demonstrated. It is now a matter of policy.
"Come here. I want you to feel a normal rectum. Do it."
add your opinions
med students
pelvic exams
Disposition of soy isoflavones in normal human breast tissue - American Journal of Clinical Nutrition
Background: Despite decades of research on the relation between soy and breast cancer, questions regarding the absorption, metabolism, and distribution of isoflavones in breast tissue largely remain unanswered.
Revisiting biographical disruption: Exploring individual embodied illness experience in people with terminal cancer
"Biographical accounts of illness offer useful insights into the social and adaptive processes of living with chronic illness. Yet there are concerns that the underlying theoretical assumptions of a reflexive self seeking to maintain meaning may not reflect the lived experience of individuals....We discuss the possibilities for new approaches to clinical assessment and management of need."
add your opinions
Wednesday, February 17, 2010
Research programs & studies - Cancer Prevention Institute of California
Research programs & studies
Studies of ovarian cancer
* Comorbidity and treatment for ovarian cancer / Survival following ovarian cancer
* Diet and risk of ovarian cancer
* Follow-up Care Us by Survivors (FOCUS study)
* Genetic epidemiology of ovarian cancer
add your opinions
The Most Outrageous Examples Of Health Insurers Denying Coverage - Huffington Post
"We compiled a list of some of the worst cases of insurance companies denying sick customers access to medical care. Check them out below -- and if you've been denied coverage, click "Participate" and tell us your story."
Can Catumaxomab Keep Away Ovarian Cancer? Video
Note: and adorable baby puppies
obituary/author: Karen Buhler-Wilkerson (ovarian cancer) nursing professor
"Karen Buhler-Wilkerson, 65, of Center City, who retired in 2006 as a professor of community health at the University of Pennsylvania School of Nursing, died Saturday at the university hospital of complications from ovarian cancer. The author of three books, Dr. Buhler-Wilkerson wrote her last paper, "Living With Cancer," with her life partner of 17 years, Dr. Neville Strumpf, for publication this summer in the quarterly journal Nursing Clinics of North America."
No clear evidence for universal supplementation -- Vitamin D
Disrupted lives and threats to identity: The experiences of people with colorectal cancer within the first year following diagnosis -- Hubbard et al. 14 (2): 131 -- Health:
Note: It's very unfortunate that this is not full access as it would apply across cancer domains.
"We conclude that universal application of the concept biographical disruption to the experience of cancer within the first year of diagnosis is not appropriate. This study has implications for cancer services, in particular, the findings call for the development of interventions to support those people who experience cancer as an assault on their identity."
add your opinions
distrupted lives
Beyond the black box: drug- and device-associated hypersensitivity events
add your opinions
black box
Genome study shows what cancers have in common - news item
"The finding, based on a large-scale study of the genetic make-up of 26 different types of cancers, suggests cancer has less to do with where in the body it occurs, and more to do with the genetic changes that cause it to grow......What that means for treatment is that many treatments may be used across many different kinds of cancers."
add your opinions
cancer. genetics common cancers
Directory of open access journals
add your opinions
open access
The cost-effectiveness of genetic testing strategies for Lynch Syndrome (U.S.)
add your opinions
Lynch Syndrome
Coherence and Completeness of Population-based Family Cancer Reports
Conclusions: These findings suggest that family history of cancer reports from the general population are generally complete and coherent.
Identification of Ovarian Cancer Symptoms in Health Insurance Claims Data
"These results support previous findings that ovarian cancer symptoms were reported in health insurance claims and were more prevalent before diagnosis, but the symptoms may occur too close to the diagnosis date to provide useful diagnostic information. The passive screening approach should be reevaluated in the future using electronic medical records; if found to be effective, the method may be potentially useful for other incident diseases."
add your opinions
ovarian cancer symptoms
If only WHI was done well -- BMJ (Drug firm conflicting interests)
"Barrington claims that the women's health initiative (WHI) trial had impeccable standards.1 We recently highlighted some of its shortcomings relating to hormone replacement therapy (HRT). The data and safety monitoring board used a global index of health which was modified on three occasions...."
add your opinions
Fluorescent probes light up cancerous tumors
In research:
"In a series of studies, working mainly in mice with implanted human tumors, the researchers showed that if tumors had spread to surrounding tissue, the ACCP-nanoparticle probes enabled them to visualize areas of tumors that they wouldn't ordinarily see -- either because the tissue was buried beneath other tissue or the tumor simply was difficult to distinguish from normal tissue."
Tuesday, February 16, 2010
WHI Study Data Confirm Short-Term Heart Disease Risks of Combination Hormone Therapy for Postmenopausal Women, February 15, 2010 News Release - National Institutes of Health (NIH)
Note: This is a re-analysis of the original study, however, between the time of the original publication and now, sub-analyses have been conducted. There continues to be wide debates on these issues.
"The NHLBI collaborates on the WHI with the National Cancer Institute, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Institute on Aging, and the Office of Research on Women's Health, all parts of the NIH. Wyeth-Ayerst Research provided the medication and placebo for the hormone study."
Hormone replacement therapy (HRT), breast cancer and tumor pathology
add your opinions
advanced cancer
Hormone replacement after gynaecological cancer
"However, the majority of the most common gynaecological malignancies like squamous cell carcinomas of the cervix, serous papillary epithelial ovarian carcinomas and squamous cell carcinomas of the vulva are not oestrogen dependent."
add your opinions
hormone replacement therapy
Mismatch repair status and outcomes after adjuvant therapy in patients with surgically staged endometrial cancer (Lynch Syndrome mutations)
OBJECTIVES: "To determine whether DNA mismatch repair (MMR) modifies the response to chemotherapy or radiotherapy in patients with endometrial cancer...... METHODS: Immunohistochemistry (IHC) for the DNA MMR proteins MLH1, MSH2, MSH6, and PMS2 was performed on a tissue microarray of specimens of primary endometrial cancer."
add your opinions
Lynch Syndrome
BRCA1 gene mutations may explain more than 80% of excess number of ovarian cancer cases after breast cancer - a population based study from the Wester
BRCA1 gene mutations may explain more than 80% of excess number of ovarian cancer cases after breast cancer - a population based study from the Western Sweden Health Care region.
add your opinions
cancer genetics risks
abstract: Surveillance for the detection of recurrent ovarian cancer: Survival impact or lead-time bias?
OBJECTIVE: "To compare the survival impact of diagnosing recurrent disease by routine surveillance testing versus clinical symptomatology in patients with recurrent epithelial ovarian cancer (EOC) who have achieved a complete response following primary therapy.....
add your opinions
ovarian cancer
abstract: Decreased severity of ovarian cancer and increased survival in hens fed a flaxseed-enriched diet for 1 year
OBJECTIVE: "With the exception of the laying hen, no other animal model of spontaneous ovarian surface epithelial cancer replicates the human disease."
Monday, February 15, 2010
Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection
"There are currently no accurate serum markers for detecting early risk of colorectal cancer (CRC)."
add your opinions
colorectal cancer
The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews -- Kirkham et al. 340: c365 -- BMJ
"Of the 42 meta-analyses with a statistically significant result only, eight (19%) became non-significant after adjustment for outcome reporting bias and 11 (26%) would have overestimated the treatment effect by 20% or more."
Outcome reporting bias is an under-recognised problem that affects the conclusions in a substantial proportion of Cochrane reviews. Individuals conducting systematic reviews need to address explicitly the issue of missing outcome data for their review to be considered a reliable source of evidence...."
add your opinions
systematic reviews
Buchanan sees cancer fight as challenge - Martinsville Bulletin - stage 1C clear cell ovarian cancer (tumour rupture)
"Now, she knows that "unless you've truly been there and done that, you cannot truly understand what it is like," she said. "I'm looking at this as a different phase in my life. If I turn that next corner, I will try to accept the things I cannot change and deal with it the best I know how. It will make me a stronger person."
Cancer Doesn't End With Treatment
Confusing association with causation - common journalistic pitfall - Gary Schwitzer's HealthNewsReview Blog
"We've just posted a new guide on the importance of the language used to describe the results of observational studies. Day after day we see stories that use active powerful verbs like "prevent...boost...lower your risk...may cut death rate" to describe the results of these studies. That's misleading and inaccurate because such studies can't prove cause-and-effect. Read more about why in this detailed, thoughtful piece by Mark Zweig, MD, and Emily DeVoto, PhD. (It's actually a revision of a piece these two wrote for us two years ago. The new one fits nicely in our "Tips for Understanding Studies" section.)"
add your opinions
7 Myths About Women Over 50
add your opinions
women over 50
Switch that turns on the spread of cancer discovered - science news report
in research: "This is often the fatal process in breast, ovarian, pancreatic and colon-rectal cancers."
add your opinions
cancer spread
Quality of Healthcare in Canada : A Chartbook | CHSRF
Note: this rather large paper includes cancer and international comparisons
Social Science & Medicine : End of Life Care Policies: Do they make a difference in practice? (analysis - Saskatchewan, Canada)
"The findings of this study demonstrate a significant gap between institutional End of Life care policies and practice..."
table of contents - Surgical Oncology Clinics of North America focus on Pancreatic Cancer
Surgical Oncology Clinics of North America, Volume 19, Issue 2, Pages 235-462 (April 2010)
Pancreatic Cancer: Current Concepts in Treatment and Research
Posted Comments: Pelvic Exams Under Anaesthesia including abstract link
Sunday, February 14, 2010
2010 abstract Teaching Pelvic Examinations Under Anaesthesia: What Do Women Think? U of Calgary
This issue of pelvic exams while under anasethesia has been explored in the research in
the past (click on 'read
more' to see viewers comments)
Please take the poll and add your views on this issue.............................................
Conclusion: "The majority of patients wish to help medical students to learn but expect consent to be sought if medical students are to perform pelvic examinations on anaesthetized patients. Before introducing explicit consent in Canadian teaching centres, it will first be necessary to determine the feasibility of seeking consent specifically for this procedure."
Please take the poll and add your views on this issue.............................................
Conclusion: "The majority of patients wish to help medical students to learn but expect consent to be sought if medical students are to perform pelvic examinations on anaesthetized patients. Before introducing explicit consent in Canadian teaching centres, it will first be necessary to determine the feasibility of seeking consent specifically for this procedure."
- Darlene Gray said...
- Sorry for being so naive, but I am shocked to find this out!!! Hell no I don't want anyone doing anything to me while I'm out cold, without at least ASKING first. Jeeeezzzzz.....
- Mon Feb 01, 10:01:00 AM EST
- Anonymous said...
- when I click on article, I get the damaged file message.
dg - Mon Feb 01, 10:07:00 AM EST
- Sandi Pniauskas said...
- Try again, please. I have tested this and it seems to work fine. Thanks.
- Mon Feb 01, 10:23:00 AM EST
- Anonymous said...
- In California teaching hospitals, the patient signs a consent form
that states that medical students and other people in training will
"participate" in the operation. If the operation is gynecological where
a pelvic exam is part of the pre-op standard of care, then a medical
student can practice the exam under supervision without explicit patient
consent. If a pelvic exam isn't necessary, then there has to be
explicit consent for a student to practice that procedure on the
Most patients aren't aware that they can be used as props in the operating room and I'm sure the hospitals and doctors want it that way. The operating room has always been known to medical students as a great place to "steal" their learning from the patient. I think what's unnerving is the vision of many students waiting their turn in line to practice on an unconscious patient. - Tue Feb 02, 01:09:00 AM EST
- Sandi Pniauskas said...
- I would really like to have med students as well as board of director members jump in here on the issue of 'vaginal cue jumping'.
- Tue Feb 02, 07:49:00 AM EST
- ginnie said...
- oh my, this is awful. next time i need surgery, i will write "i do not consent to medical students/interns/residents performing pelvic or other examinations" all over my consent forms.
- Tue Feb 02, 11:31:00 AM EST
- Chrystal Ocean said...
- What's with "it will first be necessary to determine the feasibility
of seeking consent specifically for this procedure"?
How could this possibly be an issue or a problem? How could it NOT be feasible to require prior consent? Likely the feasibility question concerns the medical schools' fear that if they ask patients for consent, they'll get more refusals than they can abide. - Wed Feb 03, 10:10:00 AM EST
- Anonymous said...
- I'm very disturbed by this article, especially as a women who had a
gynocological procedure under anesthesia 3 years ago. Had I known that
it was even a possibility that they might use me as a guinea pig, I
would have chosen to have the operation while awake, or to have someone
in the room with me while I was unconscious.
I consider this practice to be extremely unethical and leaves women open to abuse. - Wed Feb 03, 10:41:00 AM EST
- Anonymous said...
- I don't understand how they could practice ANY procedure on an
anesthetized person without consent!
Where are the ethics committees when it comes to issues like this? - Wed Feb 03, 10:48:00 AM EST
- Sandi Pniauskas said...
- I am also interested in opinions from the breast, colorectal and other cancer communities. By this I mean - is it common practice when women are undergoing any procedure to have pelvic exams while under anaesthesia? Husbands and partners opinions on this issue?
- Wed Feb 03, 01:01:00 PM EST
- Anonymous said...
- While I was aware of the general processes around student ed in
teaching hospitals - such as observing or scrubbing into surgeries - I
am very disturbed to discover what I consider at best fuzzy ethical
If it is not ABSOLUTELY CLEAR to the patient that a specific exam is part of the process, AND that participation means a supervised student may do such an exam, then you don't have informed consent. Period.
And you sure don't get that by having the patient sign a pile of forms a few hours ahead of a procedure, or assuming they know what "participate" in operation means. Stand and watch? Help monitor? Hold a kidney? I don't object to being a learning tool, but I expect to be asked specifically, simply and clearly. - Wed Feb 03, 01:46:00 PM EST
- Anonymous said...
- This is shocking news that this could become standard practice. It sounds like we are moving backwards. In 1981, I served as a "pelvic model" at UC San Francisco and was paid something like $25/hour for my time. This was strictly voluntary; I was awake,signed a consent form for serving as a teaching model, and was able to converse with the student about the pelvic exam.
- Thu Feb 04, 12:16:00 PM EST
- Anonymous said...
- Sandi, re: your comment
"is it common practice when women are undergoing any procedure to have pelvic exams while under anaesthesia?"
My heart sank when I read that question. I would love to know this too (while at the same time I dread the answer).
I'd also like to know, are men's bodies used in this experimental way? Do students practice examinations on men for testicular or prostate cancer while they are unconscious?
Sandi, I hope you'll keep us posted if you hear anything about this. Thank you. - Thu Feb 04, 12:21:00 PM EST
- Sandi Pniauskas said...
- Anonymous wrote: "Is it common practice when women are undergoing any
procedure to have pelvic exams while under anaesthesia?"
My heart sank when I read that question. I would love to know this too (while at the same time I dread the answer).
I think from some of the poll responses and comments, it is common contrary to what may think. Surgical patients of any kind, male or female should be getting on the bandwagon on this issue. The best way to bring this issue forward is to blog,email,FB and Twitter the ethics of the issue in the public domain. I wonder what husbands/partners feel about this? - Thu Feb 04, 12:43:00 PM EST
- Emily Theroux said...
- In 2003, there was a segment on the TV show 20/20 on the subject of
unauthorized pelvic exams in teaching hospitals. There was a real
uproar over this that resulted in the passage of a bill in California
intended to protect patients against this habit. A previous poster
already brought this up. Unfortunately the bill didn't help the
patient, but instead inadvertantly etched in stone that the patient
didn't have to be notified in advance, let alone get patient permission,
if a pelvic exam was part of the pre-op standard of care. These
practice exams are done before the patient is prepped and are probably
supervised by a resident or nurse. Most likely the surgeon isn't aware
(or even cares) that these exams took place because usually the surgeon
arrives in the room after the patient is draped and prepped.
A lot of debates resulted from the expose, but the doctors and hospitals were defiant in their "right" to use patient bodies in the OR as teaching props with the reasoning that a doctor can't learn just by observing. And that the patient isn't harmed. In any debate, they were uniformly indignant at revealing anything that goes on in the OR to the public because of the fear "one foot in door, what next will they demand. And the threat that if there is interference, then patient care will suffer.
Here are a few news links addressing this issue.
(yes, men are used as props too)
http://jamwa.amwa-doc.org/index.cfm?objectid=C7EE5996-D567-0B25-50D3DA2B7834FEE5 - Thu Feb 04, 04:30:00 PM EST
- Sandi Pniauskas said...
- Other links sent in anonymously:
1) http://upalumni.org/medschool/appendices/appendix-37.html
2) http://upalumni.org/medschool/appendices/appendix-49.html - Thu Feb 04, 05:43:00 PM EST
- Anonymous said...
- I had a hernia operation a few years ago. The doctor suggested general anaesthetic, but me being paranoid insisted on a lesser drug. They told me I would feel no pain and be almost asleep and not remember what happened. I felt no pain but was aware otherwise. The doctor let a student perform the surgery which I didn't know would happen. I heard the doctor's criticisms of the student's work and comments like "next time do it more this way". Quite reassuring.
- Fri Feb 05, 01:31:00 PM EST
- Sandi Pniauskas said...
- Thanks Emily for taking that extra step in providing us with related information.
- Sat Feb 06, 11:37:00 AM EST
add your opinions
pelvic exams
February 15th, 2010: Results of (unscientific poll) Pelvic Exams while under Anaesethia
- I am happy to help with learning 24 (31%)
- I do not feel permission is need 0 (0%)
- Permission is needed sometimes 1 (1%)
- Permission is needed without except 71 (93%)
- I have no concerns with the ethics of this situation 1 (1%)
- I have great concerns with the ethics of this situation 68 (89%)
- Is this today common practice - pelvic exams while under anesthesia? 22 (28%)
- Yes (common practice) 6 (7%)
- No (common practice) 7 (9%)
- How would I know? (common practice) 29 (38%)
- Is this a trust issue? 17 (22%)
- I belong to the ACOR ovarian group 35 (46%)
- I am a medical professional 11 (14%)
- Yes, I read the article 47 (61%)
- No, I didn't read the article 15 (19%)
- Was this new information for patients? 15 (19%)
- Was this new information for healthcare professionals? 13 (17%)
add your opinions
pelvic exams
The dark side of curcumin. International Journal of Cancer
a caution regarding Curcumin (partial abstract)
Sunday, February 14, 2010
Open Poll - Pelvic Exams While Under Anesthesia
Poll is Open
please contribute your views (men & women)
Patients, Consumer and Health Care Professionals
add your opinions
cancer patients genetics breast colorectal ovarian health
health care
pelvic exams
2010 abstract Teaching Pelvic Examinations Under Anaesthesia: What Do Women Think? U of Calgary
Note: This issue of pelvic exams while under anasethesia has been explored in the research in the past (click on 'read more' to see viewers comments)
Please take the poll and add your views on this issue.............................................
add your opinions
med students
pelvic exams
media links to: Teaching Pelvic Examinations Under Anaesthesia
* research abstract: "Teaching Pelvic Examinations Under Anaesthesia: What do Women Think" by Sara Wainberg from the Journal of Obstetrics&Gynecology http://www.sogc.org/jogc/abstracts/2010
* "Time to end pelvic exams done without consent" The Globe&Mail http://www.theglobeandmail.com/life/health/time-to-end-pelvic-exams-done-without-consent/article1447337/
* "When unknowing, hardly implied" The Globe&Mail Editorials http://www.theglobeandmail.com/news/opinions/editorials/when-unknowing-hardly-implied/article1451312/
add your opinions
pelvic exams
(2002) ful access: British Journal of Cancer - Heritable breast cancer in twins
Saturday, February 13, 2010
news article: The popular test you don't need
"Does this mean you should avoid CT scans? No, don't swing from scan-a-mania to scan-a-phobia. These tests can be lifesavers, provided you and your doctor use them only when the benefits outweigh the risks....."
Powerpoint presentation: Opioid-Induced Constipation: Banishing a Barrier to Successful Pain Management
see the section: "Download the Slide Presentation"
Medical News: Gabapentin Studies for Off-Label Uses Cooked? - in Neurology, Pain Management from MedPage Today
"Because the outcomes we examined were fiddled with to some extent, we don't know what the outcome was for the primary outcome that was originally set," she said.
"If I were a physician, or a patient, I would be thinking, what is the true evidence base here?"
add your opinions
Friday, February 12, 2010
Mindfulness training busts stress - CNN.com
Maurie Markman, MD, explains his passion for gynecologic cancer research | HemOncToday
excerpts from article:
"What is the best advice you've ever received?
My earliest mentor was my family physician/internist, who,
unfortunately, died of pancreatic cancer many years ago. His advice
was to make
sure I approached the practice of medicine as a people's doctor. There
nothing more rewarding than that. I took his advice very seriously and
certainly agree with it.
What would you consider one of your biggest
in your specialty?
I've been involved in the development of a number of strategies,
including the development of intraperitoneal therapy in ovarian
However, I would argue the most important thing, which I think and
I've done and continue to do, is to insist upon — for myself and
others — viewing and thinking critically about everything we do as
physicians. It's crucial that we absolutely strive for and base our
decisions on, as much as possible, solid, evidence-based medicine and
randomized trials. I believe to my core that the future of medicine
has to be
add your opinions
Gynecologic Oncologists
new Website - NCI - submit your ideas....
NCI is proud to announce an
"evolution" of our flagship Web site, Cancer.gov. We are
calling it an evolution rather than a site redesign because it is not a
one-time change. Instead of a massive overhaul, meaningful and significant Web
site enhancements will be rolled out in phases.
Using microRNAs to understand cancer biology : The Lancet Oncology
"Studies such as that by Ueda and colleagues offer hope to patients with cancer that in the future they will be offered truly tailored treatment, based on the unique biology of their tumour as defined by microRNAs."
"This type of study needs to be done for every cancer type."
MRI of Endometriotic Cysts in Association With Ovarian Carcinoma -- Tanaka et al. 194 (2): 355 -- American Journal of Roentgenology
CONCLUSION. Endometriotic cysts with enhanced mural nodules are not always complicated with malignancy. In elderly patients, the presence of large enhanced nodules on large endometriotic cysts is more likely to indicate malignancy.
Serum CA19.9 levels are commonly elevated in primary ovarian mucinous tumours but cannot be used to predict the histological subtype -- Journal of Clinical Pathology
Conclusion: Preoperative CA19.9 levels cannot be used to predict whether a suspected ovarian mucinous tumour is benign, borderline or malignant. Markedly elevated serum levels (>1000 U/ml) may be found in benign mucinous neoplasms as well as in borderline and malignant tumours.
Regional abdominal hyperthermia combined with systemic chemotherapy for the treatment of patients with ovarian cancer relapse: Results of a pilot stud
Note: warning on stats
"Results: Overall, 36 OCR patients were enrolled. The majority of the patients (>80%) were classified as platinum resistant.....
Prospective phase III trials are warranted to evaluate the benefit and efficacy in heavily pre-treated patients with OCR."
add your opinions
Adverse events experienced by homecare patients: a scoping review of the literature
CONCLUSION: A standardized definition of adverse events in the homecare setting is needed. Prospective cohort studies are needed to improve estimates and intervention studies should be undertaken to reduce the risk that homecare patients will experience adverse events.
add your opinions
adverse events
home care
PharmaLive press release: Clinical Science to publish manuscript on HTX005 ovarian cancer biomarker 'OvPlex' (plus HTX005/AGR2)
Note: the abstract included here did not indicate the number of patients involved in the studies (see prior research articles) but according to the press release showed results in stages 11/111.
"10 February 2010, Melbourne: HealthLinx Limited (ASX:HTX) has been notified by the journal Clinical Science that a manuscript submitted for review by HealthLinx scientists and collaborators at the University of Liverpool has been accepted for publication. The manuscript describes the identification of HTX005 (AGR2) as a novel biomarker released into the bloodstream of ovarian cancer patients.
The performance of the novel biomarker AGR2 will be further tested in an up-coming multi-centre, multi-national biomarker study planned by HealthLinx. Based on preliminary data it is expected that this biomarker will increase the performance of OvPlex™ to greater than 97 per cent."
Antibodies Against Abnormal Glycoproteins Identified as Possible Biomarkers for Cancer Detection, February 2, 2010 News Release - National Institutes of Health (NIH)
The team used this approach to screen blood specimens from breast, ovarian and prostate cancer patients.


text:
Reviewed by a Hotels.com guest on Feb 27, 2013
This guest did not leave a comment.
"Decent But Nothing Special"Reviewed by a Hotels.com guest on Feb 26, 2013
Overall is was ok. Still Water does not offer room service or maid service. If you want new towels, you have to exchange them at a different building. And you have to clean the room before you leave to avoid an additional charge. Since nothing is done for you, it's more like a furnished apartment than a hotel. As far as the condition of the place is concerned, it was great other than the mattress. The mattress was lumpy and uncomfortable. I mean no offense to Still Water by saying these things, I'm just being honest. If you don't mind doing things yourself when you're on vacation, then this place would perfect for you. However, I'll probably be staying at an actual hotel during my next trip to Branson.
"Very nice!"Reviewed by a Hotels.com guest on Feb 25, 2013
The hotel was perfect for our family, we had plenty of room for us the kids and the grand kids to be able to stay together but still have privacy. Very clean, and comfortable, we plan on trying to stay here again as a family in the future.
Reviewed by a Hotels.com guest on Feb 24, 2013
This guest did not leave a comment.
"AMAZING STAFF"Reviewed by a Hotels.com guest on Feb 23, 2013
This was the best business/pleasure trip I have ever had!!! Staff was amazing and location close to everything and scenery is Awesome!
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
**These amenities may be available only in some rooms or units. Some amenities may incur additional fees.
2 outdoor swimming pools and 4 indoor swimming pools are on site. In addition to a seasonal outdoor pool, other recreational amenities include a water park, a lazy river, a waterslide, and a children's pool.
Children under 13 years old are not allowed in the swimming pool without adult supervision.
The recreational activities listed below are available either on site or nearby; fees may apply.
The following fees and deposits are charged by the property at time of service, check-in, or check-out.
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
"dingy and dirty"
This hotel is old and in great need of updating! Room was dirty...comforters had stains that may have been spit up or body fluid, hair in shower, whole place was just dingy and dirty feeling! One of the drawers held a sweatshirt that God only know how long it had been there. Water park was very cold and so much smaller than the pics made it appear. […] If the rooms were better it might be worth one night's stay but definitely not 3! Read moreGenuine Hotels.com guest review
"2 night stay"
The room had no refrigerator and no micro wave and the pool is not open on Mondays and on Sunday the staffing was short so they had to flip flop water slides for the kids to rideGenuine Hotels.com guest review
"Nice place"
We liked the tower rooms. Very spacious. Water park nice and well staffed with lifeguards. The snack bar/ restaurant was understaffed but everyone was nice.Genuine Hotels.com guest review
Great place to stay, kids had fun in water park, very clean, great service. The rooms were very clean. My only advice is if you want to be close to water park stay in the tower the atrium is not connected to hotel so you have to walk across parking lot to get to the water park.Genuine Hotels.com guest review
"Kids loved the stay"
Indoor water park was the main thing why we booked this hotel. But it was sad they close on Mondays.Genuine Hotels.com guest review
"Water is very cold! BRRRR"
The room was ok, we went there for the water park. The pool was very very cold! We would have enjoyed it more if the water was warmer. Very disappointing.Genuine Hotels.com guest review
"Very impressed"
We had a great stay. Great location, great staff, great features. In reading other reviews, it seems those who were disappointed, stayed in the "Atrium" rooms, which are across the parking lot in sort of an older Motel style. We stayed in the "Tower" which was very nice and connects to the water park.Genuine Hotels.com guest review
"Would di it again"
Great price, nice place and our kids enjoyed the water park.Genuine Hotels.com guest review
Our stay at Castle Rock was very enjoyable and clean, the location was wonderful and the kids loved the waterpark.Genuine Hotels.com guest review
"Very nice!"
We had a great time at castle rock! The rooms were nice, the hotel staff was very nice and helpful. The water park was just like it was advertised, it was a very nice water park, with outstanding lifeguards! The chlorine in the lazy river was too strong but other than that it was great! We will be back!Genuine Hotels.com guest review
"Go for water park only"
This is a very mediocre facility with an indoor water park. If the water park is important, this is an OK stay. Otherwise, you can find much less expensive and nicer facilities very close by.Genuine Hotels.com guest review
"wonderful time"
We had a great time water park was fun my kids loved it so did my mom n me. We are planning on comin back next year for out vacation again.Genuine Hotels.com guest review
We checked in on a Friday evening. The indoor pool closed at 8:00 pm, which is a little early in my opinion. The pool opened on Saturday at 1:00 pm and closed at 10:00 pm, however checkout was at 11:00 am. They said that the pool was open for us to swim, however I found it inconvenient that we had no room to leave our clothes or to change afterward […] . Read moreGenuine Hotels.com guest review
The power went out we could not use the waterpark which is why we chose the hotel. Staff was not helpful when I had to carry all my luggage along with my mother and young child down the stairs. We had to check out in the dark no shower I expected at least an apology or something from the staff who by the way did not even know we're the stairs were. […] How does a hotel not have a generator. I paid for a service and did not get one Read moreGenuine Hotels.com guest review
"Nice Hotel close to main attractions in Newer Sect"
Our stay was great. I booked a day in advance. Felt the price was great considering the indoor water park and the closeness of this location to the major attractions in Branson. Would highly recommend this resort.Genuine Expedia guest review
"Excellent Stay"
We stayed in the atrium and I was a little concerned after reading reviews on here but was very pleasantly surprised! Room was very clean and well kept. Service at the desk was A+, water park was just so-so only 2 water slides but for the price it was worth every cent. Outstanding time. My 8 year old had the time of his life! Very convenient location […] to everything in the area. Read moreGenuine Hotels.com guest review
"Weekend Getaway"
If this hotel were situated anywhere else it would be way over priced. Fortunately we got a pretty great discount on Expedia. Water slides were fantastic fun for all ages!Genuine Expedia guest review
"Visited with spouse, daughters and their chiildren"
We only stayed one night, but enjoyed our stay. The pool was really fun, for those from 1 to 58 years old. Staff was friendly and cheerful. Everyone slept well, an we would stay in the tower rooms again.Genuine Expedia guest review
Nice hotel over all but did not realize that the only pool was the pay for water park.Genuine Hotels.com guest review
"Great family place!"
I was traveling with my 3 yr old and 10 yr old, as well as my parents and 15 yr old nephew and everyone in our group enjoyed the waterpark. There was something for all ages! The rooms are very basic, don't expect anything fancy, but we expected that.Genuine Hotels.com guest review
Room was ok, location ok, but becarful this is not an all year round water park. They do close and we happened to be there when this happened. Yes shame on us for being excited about having a water park in the hotel. They closed down the water park for " cleaning" we never saw anyone cleaning and we were there for 4 days. We heard life guards complaining […] of not having enough of them. Also, a slide was closed due to not having enough life guards the one day we did get to use the park. So for a main attraction to this hotel they failed!!! I would never go back to this hotel. They have much nicer hotels and a real year round water park on the strip. Read moreGenuine Hotels.com guest review
Hotel was awesome....my kids loved the bunkbed cove and the waterpark was a blast! We had a great time!!!Genuine Hotels.com guest review
We were under the impression the waterpark was included in the price but were informed it was additional per person/per day ($15.00) each. Also was under impression there was WIFI in rooms but were informed it was only available in the Lobby as they were in process of upgrading to room capabilities so some of our bills usually paid online were late […] being paid. Otherwise rooms and hotel were great and room was clean and comfortable. Also would not rely on in house restaurant which needs to expand their hours to better accommodate guests. Read moreGenuine Hotels.com guest review
"Wonderful if you have kids"
We were pleasantly surprised with the hotel. Our kids loved the indoor water park and the bunk bed nook in the tower room provided enough of an area for them to have a space for themselves. We would definitely stay here again.Genuine Hotels.com guest review
"Kids loved the hotel and the water park!"
Experience was great! We loved how clean the rooms were. The price was hard to beat. It was close to all the attractions and the water slides were a lot of fun for the whole family!Genuine Expedia guest review
Good family fun at the water park...beds some of the hardest ever slept on...had issues with tv and maintenance men came right away and fixed it. Would stay again if in area.Genuine Hotels.com guest review
"Hotel waterpark was ok . Not what I was expecting."
I felt we paid way too much money for this stay. The rooms are disappointing the beds are really bad. In all honesty I would of rather stayed at another resort without the waterpark but my grandkids wanted the waterpark.Genuine Expedia guest review
"The beds were terribly uncomfortable!"
It was pleasant other than the beds. The he water park was really fun for the children. The pools are not deep, the slides and lazy river are fun. Children love it.Genuine Expedia guest review
"Absolutely Outstanding"
We are a family of 6. The room was exceptionally clean, we inspect the beds in all hotels we stay in...this hotel had pure white sheets and not a single hair, stain or bug was found in 4 beds. The beds were more comfortable than our own at home. The waterpark was fantastic and they provide as many towels as you want. The restaurant provided a simple […] inexpensive lunch on a couple of days. It's menu is perfect for kids on vacation. This is my first time providing such a glowing review of a hotel, but for the price, location, services and cleanliness...this hotel deserves all the recognition I can offer. Read moreGenuine Hotels.com guest review
I wasn't blown away but I wasn't expecting to be. I wanted a place with enough room for us and three kids. It was great. The water park was perfect for them. The walls in the room needed new paint and could stand to be updated. But again with three kids I wasn't concerned with staying at the Plaza. My kids could be kids and we ha a blast.Genuine Hotels.com guest review
AwesomeGenuine Hotels.com guest review
"Location does not trump cleanliness"
There was mold on the shower curtain when we arrived. We informed the hotel staff, and yet the problem was not addressed. The temperature control on the shower was loose making temperature control of the water in the shower difficult to control. The dryer in the hotel's laundry facility was not functioning for the 3 days of our stay. The hotel was in […] a very convenient location, but I would never recommend this hotel or stay there again. Read moreGenuine Hotels.com guest review
"close to attractions"
Gave me a 2 bed room for 5 people and charged me for the extra person. expected them to sleep in a chair. Not happy.Genuine Expedia guest review
"Awesome experience"
My family loved staying here. We stayed in a tower room. If was worth the money and we will be returning!Genuine Hotels.com guest review
"indoor waterpark"
We took our granchildren, ages 4-14, they loved the waterpark, especially the lazy river!!!! The two youngest loved the bunkbeds in their own room with TV. Grandma and Poppa had a great time too!!!!Genuine Expedia guest review
"Great place!"
Rooms were spacious, clean & like new. Lots of great, soft pillows!! Waterpark is amazing! Lifeguards very vigilant, constantly walking, looking & keeping a close eye on everyone!! Can't wait to go back with our grandsons.Genuine Hotels.com guest review
Nice family hotel; rooms and water park were better than expected.Genuine Hotels.com guest review
"great stay"
Love this place will visit againGenuine Hotels.com guest review
The hotel staff and life guard were rude. We booked there for the water park, the slide and the kiddie pool were closed. I will never stay there again and do not recommend any one else to. There was an issue with the booking, Castle Rock did not care!!!!! It changed the mood for our vacation. Expedia corrected the issue for me and saved the day. DO […] NOT STAY AT CASTLE ROCK! Read moreGenuine Expedia guest review
"We will definitely stay her again."
The room was a nice size and clean. We had a window overlooking the water park. It rained 2 nights while we were on vacation so the waterpark was an excellent way to spend the evening with our 6 year old grandson. The only thing that was negative was there was no outside window in the room so we slept later than we should have. The room was comfortable. […] Highly recommended. Read moreGenuine Expedia guest review
"Awesome hotel"
The rooms are very nice and spacious. Loved the bunk beds for the kids. The water park was very fun.well worth the money.!!!Genuine Hotels.com guest review
"off main strip--but easy to get to"
We had our 3 grandkids at Branson for a week worth of fun. They love the water so this is one of the main reasons we decided to stay there. Good thing because it rained everyday. When we couldnt go out to visit places we used the indoor water park. We were within walking distance of miniture golf courses, go-kart tracks, resturants etc. Very close to […] all of the big attractions like the Tititanic, The Duck etc. Our room was just right for the 5 of us. 2 kids had the bunk beds & the rest of us had 2 full beds. Felt the resturant in hotel was a little pricey. We stayed in the Towers Addition. Very pleased Read moreGenuine Hotels.com guest review
"Castle rock"
Excellent location,rooms,and service---Great place to stay while in Branson!Genuine Hotels.com guest review
"Great fun for Grandkids"
We stayed in the building across the parking lot. It was a very short walk to the Waterpark. The room was newly remodeled and very clean. It was also very quite even though we had neighbors on both sides. The grandsons, ages 8 and 10 absolutely loved the Waterpark. Grandpa is 72 and he went down the water slides several times and loved it too. The boys […] want to go back again next trip to Branson and I agree with them! All the staff was friendly from the front desk to the maintenance staff and housekeepers and the lifeguards too. Read moreGenuine Expedia guest review
"very nice hotel and water park"
I almost didn't book this hotel because of the reviews that I read I'm so glad that we went the hotel is nice and the water park is awesome my grandkids loved this place will definitely come backGenuine Hotels.com guest review
"Kids really enjoyed the stay!"
Our kids had a great time at the water park...lots of different activities for them to do while we were at the stay. The staff offered an early check-in time and allowed the kids a full day of swim/play time for check-in and check-out day! It was a little noisy and the beds were not entirely comfy (we did find leftovers in the fridge, but overall it […] was a great stay! Read moreGenuine Expedia guest review
"An atrium room is not near the indoor water park."
The information is a bit misleading ( i blame expedia more than the hotel) . An atrium room at this property consists of a room at the Atrium motel next door to the Castle rock resort. Not being thrilled at the prospect of crossing half a football field of pavement to get to the pool, we upgraded to a tower room at a considerable monitary increase. […] The staff was nice and the tower rooms were clean, the beds weren't all that comfy. The resteraunt is more of a snack bar ( burgers fries pizza). No complimentary breakfast it's a buffet (i hope you like tater tots). Read moreGenuine Expedia guest review
"Indoor Water Resort"
We loved the tower room with bunk beds for the grand kids. The water slides were a big hit with our crew. We will come back.Genuine Expedia guest review
"great place"
Hotel staff was great. Waterpark was great . Room was clean.Genuine Hotels.com guest review
"Good water park"
We enjoyed the water park very much. Our room on the other hand was not so enjoyable. First of all the room was less than clean. It still had some slime on the shower curtain. Also if the floor would have been clean enough we would have slept there because the beds were the worst I have ever slept well at least attempted to sleep on.Genuine Expedia guest review
Reviews and ratings contained within this site are the subjective opinions of customers and suppliers; they do not represent or reflect Hotels.com's position. Neither Hotels.com nor the parties involved in providing review content shall be held liable for any damages of any sort resulting from use of these reviews

subset: commoncrawl


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Tuup wrote:Jaimie38 wrote:
Please explain this for the non-Americans
I see a tumbleweed, but I don't get the link to this topic... Some kind of expression I'm missing?
Hahaha! I grew up in a small town in Wyoming. I'd get nailed by these suckers walking home from school. Ouch!
BTW - I'm going to Overkill on Monday!


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Current Size: 100%
Theatre Performance |
School of Creative & Performing Arts |
Program Availability |
Advanced Diploma
Program Code:
04881 |
Six semesters, beginning in September
CONTACT INFORMATION: John Bourgeois, program co-ordinator | 416.675.6622 ext. 79034 | email@example.com
The Theatre Performance program at Humber reflects the global nature of our cultural world. We offer a unique physically based training approach to the development of theatre artists. Rigorous training in devised and original theatre is supported by foundation training in classical and contemporary approaches to text. The individual creative voice is encouraged through training in devised theatre techniques in every year of the program.
Students are taught by internationally and nationally recognized actors and actor-creators. The foundation acting curriculum includes classical, as well as contemporary acting techniques, Shakespeare, neutral mask, clown and bouffon; movement and dance; voice, speech and singing. It also includes on-camera performance; the business of acting and audition; stage combat; playwriting; puppetry and theatre history. Students work on and create original material in every year of the program. In the third year, the creative work culminates in a performance season guided by professional directors, designers, and stage managers.
Situated in the most culturally diverse city in the world, the Theatre Performance program at Humber is uniquely positioned to prepare students for the future of theatre. Our training covers everything from traditional texts to the international world of devised theatre – a rigorous approach to creating, writing, directing and/or producing. At Humber, students will develop self-motivation, self-discipline and critical thinking, as well as the entrepreneurial skills they will need to create their own unique career. Students will be prepared to move skillfully among the worlds of the professional actor: regional theatre companies, dance/theatre, film and television, and self-generated performance.
Graduates of the program receive one credit toward full membership in Alliance of Canadian Cinema, Television and Radio Artists (ACTRA).
The Theatre Performance program at Humber has ongoing relationships with professional theatre companies, which lead to co-production and mentoring possibilities for students and graduates. Agents, casting directors, and artistic directors consult frequently about our students and recent graduates. Our program Advisory Committee consists of agents, directors, artistic directors and producers from both the commercial and the not-for-profit worlds of performance.
– presentation of one prepared monologue
– a creative workshop
– a voice and movement assessment
– an interview
– an English essay (topic assigned at session), which will be assessed for English proficiency
Graduates of this program are eligible for the Consecutive Honours (Acting) Bachelor of Fine Arts (BFA) program at York University. Qualified graduates of this program may also be eligible to apply their academic credits toward further study at many other postsecondary
For detailed information, visit our website at humber.ca/transferguide.
The 2012/2013 fee for two semesters is
– domestic $5,467.60
– international $12,800.
Amounts listed are the total of tuition, lab and material fees, student service and auxiliary fees for the first two semesters of the 2012/2013 academic year.
Fees are subject to change.
For more information visit Fees and Financial Assistance.
$50 – theatre tickets (per semester).
Semester 1 | ||
Course Code | Course | Credits |
COMM 200 | College Writing SkillsCollege Writing SkillsCourse Code: COMM 200 Credits: 3 College Writing Skills emphasizes elements of the writing process. Although subject matter and format may change from one program to another, the skills necessary for effective writing remain the same, as do the professional standards that all Humber students are expected to attain.
Students will practice the reading and writing skills that will be valuable in their college programs and build a strong base for professional business writing. Those students who plan to further their studies will develop the fundamental skills for writing acceptable academic English.
To help students reach these goals, the course covers the following: analytical reading and critical thinking; essay organization and development; and the elements of clear writing, including grammar and punctuation skills.
To complete COMM 200 successfully, students must produce writing that meets or surpasses the minimum departmental standards as set out in the attached criterion sheet.
| 3 |
HUMA 024 | Humanities: An Introduction to Arts and ScienceHumanities: An Introduction to Arts and ScienceCourse Code: HUMA 024 Credits: 3 The Humanities course focuses on fundamental questions individuals ask of themselves as they proceed through life. Why are we the way we are? Do we have free will or are we prisoners of our past experience or our biological inheritance? What motivates societies to change? Why do societal changes so often divide people into opposing camps? Why do so many people find contemporary life at home, at work, and in the community unfulfilling? What constitutes good government? How should injustice be fought? Can nations successfully deal with global problems? What is science and how does it differ from other kinds of inquiry? Can scientists provide solutions to the problems we face? What is art and does it offer answers of its own? What is its relationship to beauty, to knowledge, and to ethics? Is objectivity about art (or anything) possible? These questions are organized into units that begin with issues concerning the nature of the individual and then extend outward to various social, cultural and physical contexts.
The issues explored in this course are too complex to have any one right answer. Rather, individuals must search for answers that make sense of their experiences via various theoretical perspectives. The Humanities course supports this endeavour through study of different thinkers presented in the readings and exploration of different points of view explored in class discussions.
ESL students should consider taking the ESL Humanities course. Students may transfer into
ESL Humanities (HESL 024) either at the Registrar?s Office or the School of Liberal Arts & Sciences
Office (K201) on a first-come, first-served basis before the Last Day to Add. | 3 |
THTR 100 | Acting Techniques 1Acting Techniques 1Course Code: THTR 100 Credits: 6 The course will concentrate on the development of basic acting skills. Included will be work on the actor's instrument, creativity, imagination, observation and discipline. Students will explore improvisational techniques and work with neutral mask. The focus will be on process rather than immediate results. | 6 |
THTR 101 | Voice 1Voice 1Course Code: THTR 101 Credits: 5 Voice 1 offers practical studio classes providing an introduction to voice work for actors. Students will be introduced to the process of freeing and expanding their voices as actors. Students will explore the sounds of the English language both creatively and technically. Choral singing is an essential component of the work. | 5 |
THTR 102 | Movement 1Movement 1Course Code: THTR 102 Credits: 4 Movement 1 offers a foundation for the movement curriculum in the performance program. Students will engage in the essential tasks of alignment and conditioning and develop enhanced endurance, suppleness, awareness, economy, and precision in moving. Through improvisations and guided experimentation in a variety of movement practices, students will explore the interrelationship of mind, spirit and body. Training in formal techniques such as Chi Kung and African dance will also be included. | 4 |
THTR 110 | Introduction to Theatre 1Introduction to Theatre 1Course Code: THTR 110 Credits: 2 Introduction to Theatre 1 is intended to provide beginning students with an overview of the theory and practice of theatre. Through this course, students will be encouraged to develop and articulate a personal aesthetic, a professional attitude and a more complete understanding of theatre practice. The course will also include a series of independent learning projects selected with a view to expanding student knowledge of dramatic literature and theatre practice. | 2 |
Semester 4 | Course Code | Course | Credits |
THTR 400 | Acting Techniques 4Acting Techniques 4Course Code: THTR 400 Credits: 10 Refer to course description THTR 300 Acting Techniques 3. Students will spend a more extended period working with Shakespeare's text in a variety of ways, culminating in an original presentation of one of the plays. Students will also be introduced to physical training approaches that lead to the creation of a performance. | 10 |
THTR 401 | Voice 4Voice 4Course Code: THTR 401 Credits: 5 Refer to course description THTR 301 Voice 3. | 5 |
THTR 402 | Movement 4Movement 4Course Code: THTR 402 Credits: 6 Refer to course description THTR 302 Movement 3. Components of the course will focus attention on characterization and other individual movement issues within an acting context. | 6 |
THTR 410 | Theatre History 2Theatre History 2Course Code: THTR 410 Credits: 2 Refer to course description THTR310 Theatre History 1. | 2 |
Semester 6 | Course Code | Course | Credits |
THTR 600 | Rehearsal/Performance 2Rehearsal/Performance 2Course Code: THTR 600 Credits: 10 Refer to course description THTR 500 Rehearsal/Performance 1. | 10 |
THTR 601 | Voice 6Voice 6Course Code: THTR 601 Credits: 3 Refer to course description THTR 501 Voice 5. | 3 |
THTR 602 | Movement 6Movement 6Course Code: THTR 602 Credits: 3 Refer to course description THTR 502 Movement 5. | 3 |
THTR 605 | Professional Orientation 2Professional Orientation 2Course Code: THTR 605 Credits: 2 Refer to course description THTR 505 Professional Orientation. | 2 |
Humber offers pathways from Ontario college diplomas to Humber degrees. Find out where your diploma can take you.
You can also choose another postsecondary institution. Humber has formal articulation agreements indicating the specific transfer arrangements from a Humber program to a particular degree program, as well as general policies on admissions at specific institutions. Click here to find out more.


text:
Marc by Marc Jacobs
Indigo Denim
Fashion legend Marc Jacobs introduced his diffusion line, Marc by Marc Jacobs, with a spring 2001 runway show. He has gone on to win seven CFDA awards including Womenswear Designer of the Year, Accessories Designer of the Year and Menswear designer of the year.
- Wash - Indigo
- 34.5" Inseam
- 9.5" Rise
- 100% cotton
- 15" in the knee and 15" at the leg opening
- Button fly
- Slight whiskering along front pockets
- Intentional fading throughout
- Styled with Keds Triumph Chambray Lace in Tan.
- Modeled in size 32. See fit guide for model's dimensions.
- Revolve Style No. MARC-MJ16
- Manufacturer Style No. M4001027


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Originally Posted by DrivenByDemons Clutch is a smart smart man based on OP
This made me Smile and Laugh for 3 mins straight
Who the fuck are you?
Originally Posted by Schmoopy Most of the oil evaporated on its own and oil leaks from the ocean floor naturally every single day.
dogs are good for your health.
Originally Posted by Schmoopy I'm above the MENSA level.
Clutch took me off igno.
Forum Rules


text:
kayanat wrote:I want to start mountain biking and don't know too much about it. Should I buy and expensive bike from a bike shop or go to a retail store and buy what looks okay to ride?
SoloShot, is it worth the money? RELATED: Surfing Hardware Author: WaveHunter Replies: 13 |
This board any good? or have i wasted money? RELATED: Shortboarders Only Author: proudmama Replies: 17 |
Is Oneil Heat, Oneil Reactor, ExcelSLX better for the money? RELATED: Surfing Hardware Author: drewbabich Replies: 2 |
Mountain Biking RELATED: General Chat Author: little waves Replies: 8 |
Biking with a board? RELATED: Surfing Travel Tips, Spot Locations and Info Author: GoatRider Replies: 7 |


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Since the 9/11 attacks, no book has provided a satisfactory answer as to WHY the attacks occurred and who was ultimately responsible for carrying them out - until now.
"If you have to explain the concept of intelligence, it is in fact the ability to make sensible choices - to anticipate future challenges. And this is where nicotine can help"he told the newspaper. Gjedde also refers to the Swedish professor of genetic developmental biology, Klas Kullander, who found that nicotine promotes learning and memory: "Nicotine affects receptors in the memory center. You simply get better at organizing his memory. ", said Gjedde.


text:
News & Announcements
Centenary Basketball Fundraiser with Professional Basketball Team Scheduled for March 9, 2013
Hackettstown, N.J. – Come to Centenary on March 9, 2013, for an evening of basketball and fun! A children's basketball clinic will take place from 5 p.m. to 6 p.m. where children from the ages of 5 to 12 can be mentored by the New York Wizards, a professional basketball team based in Deer Park, New York. Attendees can also stay to watch the New York Wizards game when they take on Centenary staff, faculty and students at 7 p.m. Both events will take place at the John M. Reeves Student Recreation Center. Parking is located at 715 Grand Avenue in Hackettstown.
The cost to attend the clinic is $5 per person and the cost to attend the game is also $5. The children's basketball clinic will include a "meet and greet" with the Wizards and the game will feature halftime activities for all attendees.
"This is a wonderful opportunity for people in the community to participate in a clinic and be mentored by a professional basketball team, then watch them play a fun game with members of the Centenary community," says Perricone.
This project is an independent study for Centenary senior Robert Sporman, who is a resident of Hillsborough, under the direction of Centenary College Assistant Professor of Sports Management David Perricone. Sports Management students are also working on this project by organizing the clinic and securing sponsors.
A portion of the funds will go to the Perricone's Family Sports Management Scholarship. This Scholarship was instituted at Centenary College in 2011. It is awarded to one Sports Management student per year who demonstrates leadership skills and volunteers outside of the classroom.
"My parents have taught me and my brother to always give back and remember where you came from," says Perricone. "The Perricone family is pleased to have established this scholarship and to help provide financial support to a student who aspires to have a career in the sports industry."
For more information and to register, please contact Professor Perricone at (908) 852-1400, ext. 2357. Interested parties must register for the clinic by March 1, 2013.
The New York Wizards were founded in 2008 and play in the Eastern Basketball Alliance. Their head coach is Greg Cerillo, Senior.
Founded in 1867 by the Newark Conference of the United Methodist Church, Centenary College is an independent, coeducational liberal arts and career studies college distinguished by an accomplished faculty, small class size and diverse student body. Centenary is the only baccalaureate and master's degree granting institution in northwest New Jersey.
Centenary College's main campus is located in Hackettstown, N.J., with its equestrian facility in Washington Township (Morris County). The Centenary College School of Professional Studies offers degree programs in three locations: Hackettstown, Parsippany and Edison, and at corporate sites throughout New Jersey. The School of International Programs recruits international students for study at Centenary and Centenary students for study abroad.


text:
You're watching...
Prediction: Chris Christie will run for President in 2016
Tip of the Day 2/5
Feb 5, 2013
You're watching...
Tip of the Day 2/5
Feb 5, 2013
Also in this playlist...
Auto-advance: ON
Auto-advanceThis transcript is automatically generated
The factor tip of the day whenever you hear a politician make fun of him or herself whenever you hear that you know they want your vote.
On Letterman last night Chris Christie talked about two jokes Dave told that mocked him.
Tiger still memento we -- -- -- what's celebrity birthday today Chris Christie turned fifty he blew out the candles on this cake.
And he wished for another cake.
And that's what I thought I look this is what your best ones yeah but I think it's very topical given that what went on yesterday.
A billion dollars will be spent a dictatorship for Super Bowl Sunday and that's just a Governor Christie touts.
-- Chris Christie definitely wants to run for president to sixteen.
No question and he'll be up against Rand Paul had -- -- broadcast and I thing.
He's going to be up against the junior senator from Florida as well that's a handicap now John cases -- -- -- -- highly might get in there.
All right but it Marco Rubio Chris Chris the Rand Paul if -- locks at this point -- -- happened but then they wanna go.
And you have to start planning it is it's insane in this country if you wanna run for president you got to go out three years and raise the money factor tip of the day.
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My favorite movie genre is true sports stories. This one never fails to make me laugh, be inspired look forward to the winter Olympics.
Thanks for having this dvd in stock. It is a great movie. This was a gift for my sister in West Africa.
Very happy with the fast delivery. I wasn't expecting to receive it so quickly. It was a pleasant surprise. Overall, this is a great family movie and had lots of laughs.
classic disney movie for kids, especially during the winter olympics 2010.
I have always liked this movie and when the Olympics came on, that was the movie I thought about. It's a very inspirational, funny and incouraging movie. To think Jamaica had the guts to do the unthinkable and became great at it. The ending was touching and the caring of the egg!
This item will be delivered to you via USPS Trackable Media Mail or UPS Mail Innovations and will take from 2 days to 3 weeks from the time the item leaves our warehouse. *
Items must be returned in new or unused condition and contain all original materials included with the shipment. More details
FINAL SALE EXCLUSION: Items marked as FINAL SALE are not returnable unless the problem you experience is the result of our error.
* For your safety, some orders go through our loss prevention department. If we select your order for this process, we will immediately notify you that there may be up to a 3-day delay on your order.
** Most Oversize orders are delivered within 1-4 weeks. Some orders may take 6 weeks to be delivered.