text:
Overview of the Fieldhouse Complex
The Fieldhouse/Recreation Center is a site for performance excellence. The center is the home of the 2002, 2003, 2005 and 2006 National Championship GVSU Laker Football team, as well as the 2005 Women's Volleyball National Championship team and the 2006 Women's Basketball National Championship team. Other competitive GVSU athletic teams have risen to the top of NCAA Division II competition year in and year out. Many of GVSU's athletes are recognized for academic achievements, as well. In recent years, GVSU has won the NCAA All Sports Trophy, which is the measure of total program excellence in NCAA Division II.
Recent additions to the facility included a recreational gymnasium with wood flooring, an elevated track for jogging and walking, and extensive cardiovascular and selectorized areas. The most recent addition occurred in 2002 and included a third enclosed gymnasium, and extensive cardiovascular space and equipment, a weight lifting center and a spinning/rowing room.
Page last modified September 25, 2013


text:
5 bedroom detached house for sale Hartsbourne Avenue, Bushey Heath, Hertfordshire, WD23 1JP
STUNNING PROPERTY! This FAMILY HOME'S greatest appeal is its LOCATION which sees it BACKING ONTO THE 10TH GREEN OF THE HARTSBOURNE COUNTRY CLUB. Complete with MINIMUM 5 BEDROOMS, 3 OF WHICH HAVE EN-SUITE BATHROOMS, this luxurious interior designed property also features a GYM and CINEMA ROOM. More details ›
6 bedroom detached house for sale Prowse Avenue, Bushey Heath, WD23
Fabulous 5/6 bedroom family home, traditionally styled on the outside but with a homely and contemporary interior. More details ›
6 bedroom detached house for sale Woodfield Rise, Bushey
Benefits include ensuite facilities and air conditioning to all six bedrooms , underfloor heating to downstairs and all bedrooms, spacious living areas including an annex consisting of three rooms, a mature and well kept garden with swimming pool and function building at the rear of the garden. More details ›
3 bedroom apartment for sale Hartsbourne Park, 180 High Road, Bushey Heath, Herts, WD23 1SD
VIEW TODAY! The LARGEST PENTHOUSE APARTMENT in this AWARD WINNING development is NOW AVAILABLE to view!!! With TWO LARGE TERRACES, a CONCIERGE and THREE PARKING SPACES (2x UNDERGROUND) this luxury flat is a MUST SEE! More details ›
6 bedroom property for sale Heathbourne Road, Bushey Heath
On a plot of approximately 1 acre is this rarely available detached bungalow approaching 2350 sq ft. The accommodation currently comprises of a 42ft reception room, kitchen/family room with direct access to the garden, 6 bedrooms, 2 bathrooms including a dressing room and en-suite to master bedro... More details ›
3 bedroom penthouse for sale High Road, Bushey Heath, Bushey, WD23
Spacious 3 bedroom, lateral penthouse apartment comprising in excess of 2,100 sq ft (191 sq m) of indulgent living space, with features including 2 stunning terraces. More details ›
£1,500,000Guide Price
Guide Price £1,500,000
3 bedroom flat for sale JFK House, Royal Connaught Park, The Avenue, Bushey, WD23 2RA
An exceptional duplex apartment, formerly the show home, for sale complete with furnishings. More details ›
- Photos: 10
- Floorplans: 0
4 bedroom house for sale Heathbourne Road, Bushey Heath, Bushey
A stunning contemporary home offering great light and space. This property sits on a large plot, ideal for entertaining and for those looking for a large garden surrounded by beautiful trees. This property comprises four double bedrooms, two large lounges, a semi open plan kitchen and a la... More details ›
Marketed by CH Peppiatt, London.Telephone: 020 3324 6894 Local call rate
£1,350,000Guide Price
Guide Price £1,350,000
4 bedroom detached house for sale The Mullions, Hartsbourne Road, Bushey Heath, Herts, WD23 1JJ
VIEW TODAY! This Tudor-style 4/5 BEDROOM DETACHED HOUSE was built 30 years ago for the current owners. Situated in one of BUSHEY HEATH'S MOST PRESTIGIOUS TURNINGS, HARTSBOURNE ROAD, this home features 3 reception rooms, 3 BATHROOMS, a double garage, and GORGEOUS GARDEN. More details ›
4 bedroom detached house for sale Caldecote Lane, Bushey
A delightful opportunity to acquire this charming former stables in Caldecote Lane, Bushey Heath. Set out over two floors, and designed in a horse shoe shape this family home offers flexible and well balanced accommodation plus the added benefit and potential for further internal refurbishment an... More details ›

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West Fargo Pioneer
McPhee wins new utility vehicle from 4-H Foundation raffle
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January 23, 2013
West Fargo man gets 30 days for lighting girlfriend's porch on fire
FARGO - Bruce Risberg is going to jail on Monday, and he and his longtime girlfriend - whose porch he was charged with lighting on fire - have nothing but good things to say about it. "My case turned out awesome," said the West Fargo man after his sentencing Tuesday in Cass County...
January 23, 2013 - 9:17am
December 10, 2012
Vehicle sought in West Fargo hit-and-run
WEST FARGO - Police here are asking for the public's help in finding an SUV involved in a hit-and-run crash Sunday. It occurred at about 2 a.m. at Ninth Street East and 13th Avenue. A witness following the SUV told police it ran a red light and struck another vehicle in the intersection,...
December 10, 2012 - 8:50am
September 20, 2012
Authorities conduct drug sweep at West Fargo High School
WEST FARGO - Authorities conducted a drug sweep Wednesday of parking areas at West Fargo High School as part of a drug-free school campus campaign, leading to the recovery of marijuana and marijuana paraphernalia from three vehicles, police said. Drug-sniffing dogs and their handlers...
September 20, 2012 - 8:47am
September 7, 2012
Moorhead investigating garbage bin fires
MOORHEAD, Minn. – A south Moorhead neighborhood has been plagued with garbage bin fires for the past month or so, according to Fire Chief Rich Duysen. Duysen said about half a dozen fires have been reported in metal garbage bins south of Minnesota State University Moorhead...
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September 7, 2012 - 9:15am
Cloquet man who kidnapped son avoids prison
DULUTH -- A Cloquet, Minn., man who kidnapped his 7-year-old son from his ex-wife for 11 days in March was sentenced Thursday to two years at the Northeast Regional Corrections Center and 10 years of supervised probation and was ordered to undergo chemical dependency and mental...
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September 7, 2012 - 9:11am
Murder charge dropped, defendant released
DULUTH - A Duluth man held in the St. Louis County Jail since April on a murder charge has been released. Prosecutors have dropped charges against 37-year-old Nakota Benjamin, one of two men accused of killing 28-year-old Joshua Olson at an apartment building in Duluth last April....
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September 7, 2012 - 9:05am
September 5, 2012
Drugs seized after Cass traffic stop
WALKER – Two men face drug charges after a traffic stop Sunday in Cass County. Cass County Sheriff Tom Burch said a deputy initiated a stop on a vehicle northbound on Minnesota Highway 64. After a short pursuit, authorities stopped the vehicle near County Road 20 in Ansel...
news / local
September 5, 2012 - 2:07pm
UPDATED: Officer accused of kicking suspect previously disciplined
ST. PAUL, Minn. (AP) — A St. Paul police officer shown in an online video kicking a suspect who was lying on a sidewalk last month had been disciplined for excessive use of force in 2006 when he worked for the St. Paul Park police department, according to police records. Jesse Zilge,...
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September 5, 2012 - 12:34pm
Nurse charged with stealing meds from patients
ST. CLOUD, Minn. (AP) — A Minnesota nurse is charged with siphoning pain medication from patients' intravenous bags at a hospital and replacing the drugs with saline solution. The defense attorney for Blake Daniel Zenner confirms his client is the nurse accused of introducing...
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September 5, 2012 - 12:32pm
Man sentenced to more than 30 year for murder
WILLMAR, Minn. — The rural Paynesville man charged with shooting and killing a man after an argument was sentenced Tuesday to the maximum allowed, more the 30 years in prison. Delbert Edwin Huber, 82, of rural Paynesville was sentenced to 367 months for shooting and killing Timothy...
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September 5, 2012 - 9:43am
September 4, 2012
Drunken driving deaths decline in Minnesota
ST. PAUL, Minn. (AP) — A new report shows the number of drunken driving deaths is declining in Minnesota. The Department of Public Safety says 111 people died from drunken driving in 2011, compared with 185 deaths a decade ago. Minnesota State Patrol Lt. Tom Shmitz says the weekend...
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September 4, 2012 - 8:47am
August 31, 2012
ND man pleads guilty in synthetic drug overdose
FARGO, N.D. (AP) — A North Dakota teen has pleaded guilty to dealing synthetic drugs that led to the overdose death of a Grand Forks teen. Wesley Sweeney, of Manvel, appeared Friday in federal court. He pleaded guilty to a charge of conspiracy to distribute drugs that resulted in...
August 31, 2012 - 12:30pm
Police fatally shoot 1 person at Woodbury motel
WOODBURY, Minn. (AP) — Authorities say a man who died following a disturbance at a Woodbury motel was shot by police. Officers were called to the Red Roof Inn about 1:10 a.m. Friday. Police say the dispatcher who took the 911 call could hear a struggle in the background and the...
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August 31, 2012 - 12:28pm
Official: NJ supermarket shooter is ex-Marine
OLD BRIDGE, N.J. (AP) — A law enforcement official says the gunman who killed two co-workers and himself at a New Jersey supermarket is a former Marine. Twenty-three-year-old Terence Tyler was discharged from the U.S. Marine Corps. in 2010. The military says he never served overseas...
August 31, 2012 - 12:16pm
Gun-point robbery reported at Alexandria video store
ALEXANDRIA, Minn. -- An armed robbery was reported at Premiere Video in Alexandria just before midnight Wednesday. Alexandria police officers responded to a 911 call and were told an employee who was closing up for the night was robbed at gunpoint. There were no physical injuries...
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August 31, 2012 - 3:12am
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Light up your shop with inexpensive, 8-ft.long fluorescent light fixtures. With electronic ballasts and bulbs with a color rendering index of at least 85, you'll have lights that show true color and turn on no matter how cold it is.
By the DIY experts of The Family Handyman Magazine
You should be familiar with basic wiring
To efficiently light up a two-car garage, remove the bare-bulb porcelain fixtures (remember to turn off the power first) and replace each with an 8-ft. fluorescent fixture. (We recommend one 8-ft. fixture per vehicle space.) We like the type that use 4-ft. bulbs; the 8-ft. bulbs are difficult to handle. You can position the new lights to mount right over the existing ceiling boxes.
Keep in mind that not all fluorescent lights work in cold weather. Select your fluorescent fixture based on the lowest temperature in your garage. Refer to starting temperatures printed on the ballast. Regular magnetic ballasts in standard T12 fluorescent fixtures (which have 1-1/2 in. diameter lamps) are not recommended for temperatures below 50 degrees F.
If the temperature in your garage drops below 50 degrees, buy fixtures with electronic ballasts (not electromagnetic) because they start in temperatures down to 0 degrees F and lower. We recommend you buy fixtures that take size T8 lamps (1 in. wide), which are more energy efficient. They cost more initially but will save you money over time. Avoid energy-saver T12 lamps; they need a minimum of 60 degrees to operate properly.
When buying bulbs, especially for a woodworking shop where you need to see the true color of paints and stains, ask for lamps with a CRI (color rendering index) of 85 or above. This number usually isn't printed on the bulb or packaging, but it's listed in the bulb company's product catalog (and on some Web sites).
Once you know the exact ceiling fixture location, drill a 7/8-in. hole in the base of the fluorescent light's metal housing, directly over the existing ceiling box. Buy a 1/2-in. electrical bushing (at home centers and hardware stores) and snap it into the newly drilled hole so sharp metal edges won't cut into wires. Then attach the fixtures to the drywall ceiling by screwing them directly into ceiling joists.
Note: Make sure a ground wire is present and fasten it to the metal body of the fluorescent fixture.
Replace bare bulbs with fluorescent fixtures for brighter, more consistent light.
Look for the cold starting temperature, which is only printed on the ballast label.
Overhead fluorescent fixtures provide ample light for doing woodworking projects, or working on your car, motorcycle or boat.
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I currently have two 8 foot long flourescent fixtures in my 2 car garage workshop (Attached garage). They give great light, but from the beginning, they interfere with AM radio and phone reception. they are the type that can function in cold temperature. what can I replace them with? Help !
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I guess I should disclose right off the bat that I do not like musicals, but I'd hazard that even those who do might have trouble getting into this trailer for Adam Shankman's 'Rock of Ages.' This star-packed film takes place in 1987 L.A. and is essentially a love story set against an epic rock scene. The film's cast includes Alec Baldwin, Catherine Zeta-Jones, Paul Giamatti, Russell Brand, and Tom Cruise as fictional rock legend Stacee Jaxx. My problem here is that this looks like the 'Glee' approach to 80s rock and that immediately had me tuning out. Plus, when we actually hear Cruise sing, his voice (or at least the voice they're suggesting is his) sounds like eerily like Weird Al Yankovic. But hey, that's just my opinion. Take a look at the trailer below and let us know what you think.
'Rock of Ages' hits theaters June 15th
This is bubblegum Rock...Please do a trailer talk so Co-Host can rage all over this hot mess
It could be one of those..... Guilty Pleasure movies (similarly to Moulin Rouge and Chicago)
It is like Kidz Bop... for adults!!!
This is..........kinda weird.
How can you not like musicals? You like movies? You like music? Wizard of Oz? Sound of Music? Blues Brothers? Tenacious D? Moulin Rouge? Little Shop of Horrors? Dr. Horrible's Sing Along Blog? Aladdin? Lion King? Any of these ringing a bell? Sure plenty of musicals are cheesy, and we all know Glee sucks ass, but musicals have been proven to work just like every other genre. It just depends on whether the narrative is good, the music is good, and they compliment each other. Movies and music joining forces can lead to a synergy in which the sum is greater than the parts.
mmmmmm......interesting. I wish it wasn't a musical.
Why, Tom, Whyyyyyyyyy??????!!!?!?!?!?
this looks veeeeery bad, but i bet russell brand and alec baldwin will be funny side characters
"That stage is a pedestal." Really, a stage is a pedestal? Deeeeeeeeep.
It indeed does feel like they put the ''GLEE EFFECT' on 80's rock
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Research by life and protection comparison website money-minder.com has found that the lowest and highest premiums for simple level term life assurance bought online can differ by as much as 30%.
Using one example, a 31-year-old male non-smoker taking out £200,000 worth of level term life assurance for 25 years found the lowest guaranteed premium of £9.60 per month compared to £13.58 from another insurer. Over the lifetime of the policy the difference would amount to a saving of £1194.For smokers the savings could be even higher.
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Linux on System z
History of IBM mainframe operating systems |
DOS/360 and successors (1966)
Linux on System z is the collective term for the Linux operating system compiled to run on IBM mainframes, especially System z machines. Other terms with the same meaning include Linux on zEnterprise 196, Linux on System z10, Linux on System z9, Linux on zSeries, Linux/390, zLinux, z/Linux, etc.
Linux on System z originated as two separate efforts to port Linux to IBM's largest servers. The first effort, the "Bigfoot" project, developed by Linas Vepstas in late 1998 through early 1999, was an independent distribution and has since been abandoned.[1] IBM published a collection of patches and additions to the Linux 2.2.13 kernel on December 18, 1999, to start today's mainline Linux on System z.[2] Formal product announcements quickly followed in 2000, including the Integrated Facility for Linux (IFL) engines. Think Blue Linux was an early mainframe distribution consisting mainly of Red Hat packages added to the IBM kernel.[3] Commercial Linux distributors introduced mainframe editions very quickly after the initial kernel work, and these mainframe versions have now been available for several years.
At the start of IBM's involvement, Linux patches for System z included some object code only (OCO) modules, without source code.[4] However, currently Linux on System z is completely free software under the GNU General Public License.[citation needed]
As of May 2006, according to IBM, over 1,700 customers run Linux on their mainframes.[5]
Linux is always run in a virtual environment on IBM System z mainframes. Virtualization is handled either via LPARs, or by running under the z/VM hypervisor. The distinction is transparent to the Linux virtual machine.[6]
When Linux applications access mainframe-based data and applications in CICS, IBM DB2, IMS, and other mainframe subsystems, running on the same physical mainframe, they can utilize HiperSockets – fast, memory-only TCP/IP connections. As compared to TCP/IP over standard network interface cards (NICs, in the mainframe world called Open System Adapters, OSAs), HiperSockets can improve end-user responsiveness (reduce network latency and processing overhead), security (since there's no network connection to intercept), and reliability (since there's no network connection to lose).[7]
Linux on System z is available in both 31-bit and 64-bit versions. The Linux kernel architecture designation is "s390" for 31-bit kernels and "s390x" for 64-bit kernels.[6] 64-bit distributions can still run 31-bit applications. The 31-bit versions are rapidly losing favor as z/Architecture mainframes become more prevalent than the earlier ESA/390 generation.
The Linux 2.6.x kernel added substantial support for mainframe hardware, such as ESCON, FICON, SCSI-attached storage devices, and System z cryptographic accelerators. Also several vendor distributions backported 2.6.x patches to the Linux 2.4.x kernel.
Linux runs on standard general-purpose CPs (Central Processors) as well as IFLs (Integrated Facility for Linux). IFLs are mainframe processors dedicated to running Linux, either natively or under z/VM. Microcode restricts IFLs from running "traditional" workloads, such as z/OS; they are otherwise identical to other System z processors. IFLs are typically less expensive to license from IBM than CPs.[8]
Linux on System z gives the flexibility of running Linux with the advantages of mainframe hardware. Using virtualization, numerous smaller servers can be combined onto one mainframe, gaining some benefits of centralization, but allowing specialized servers thanks to virtualization support, which can lower operating costs. IBM mainframes allow transparent use of redundant processor execution steps and integrity checking, which is necessary in the financial services industries[citation needed]. Mainframes typically allow hot-swapping of hardware, such as processors and memory. This swapping is typically transparent to the operating system, allowing routine repairs to be performed without shutting down the system.
Pricing and costs[edit]
Linux on System z is not appropriate for small businesses that would have fewer than about 10 distributed Linux servers, although some expensive per-processor licensed software can quickly reduce that rule of thumb. Most software vendors, including IBM, treat the highly virtualized IFLs just like non-virtualized processors on other platforms for licensing purposes. In other words, a single IFL running scores of Linux instances still counts as one "ordinary" CPU, at the same CPU price, for software licensing. Test, development, quality assurance, training, and redundant production server instances can all run on one IFL (or more IFLs, but only if needed for peak demand performance capacity). Thus, beyond some minimum threshold, Linux on System z can quickly become cost-advantageous when factoring in labor and software costs.
The cost equation for Linux on System z is not always well understood and is controversial, and many businesses and governments have difficulty measuring, much less basing decisions on, software, labor, and other costs (such as the costs of outage and security breaches). Acquisition costs are often more visible, and small, non-scalable servers are "cheap." Nonetheless, non-acquisition costs are no less real and are usually far greater than hardware acquisition prices[citation needed]. Also, individual users and departments within larger businesses and governments sometimes have difficulty sharing computing infrastructure (or any other resources, for that matter), citing a loss of control. Server centralization, as Linux on System z provides, might reward cooperation with better service and lower costs, but that's not to say that cooperation is always easily accomplished within a corporate bureaucracy.
Linux on System z also supports less expensive disk storage devices than z/OS because Linux does not require FICON or ESCON attachment, although z/OS may use disk space more efficiently due to hardware-assisted database compression on z/OS. This compression effect is somewhat variable and may be somewhat reduced due to the minimum space allocation requirements for z/OS data sets (a full disk track).
Appropriate workloads[edit]
Mainframe characteristics are designed for such business workloads as transaction processing or large database management. Mainframe design emphasizes input/output performance, implemented via channel I/O. Historically, the principle is to offload I/O activities from the CPU as much as possible, and the z/Architecture additionally offloads cryptographic calculations. Mainframes can scale to numerous processors in a single frame, e.g. up to 64 processors in the case of the System z10 EC Model E64, which gives as much as 28.000 MIPS.
On the other hand, mainframes in general, and Linux on System z in particular, do not perform well for single task computations. Examples include most scientific simulations, weather forecasting, and molecular modeling. Supercomputers, including Linux-based supercomputers, excel at these workloads. This distinction has blurred since the introduction of the System z10, a machine based on quad-core 4.4 GHz processors with hardware decimal floating point. In this regard, the System z10 more resembles a supercomputer processor than previous mainframes.
Mainframes do not provide graphics or sound adapters, and are as such ill-suited for digital media editing or computer-aided design (CAD) except perhaps in support roles (e.g. content storage, parts inventories, etc.)
Like all other versions of Linux, Linux on System z is governed by the GPL free software license. Complete Linux on System z source code is available from numerous groups on a free and equal basis, and architectural support is now part of the main Linux kernel effort. IBM assigns several of its programmers to the community effort, but IBM is by no means the only participant.
IBM currently supports two Linux distributions, Red Hat and SUSE.[9] Other notable Linux on System z distributions are Debian,[10] Gentoo and Fedora.[11]
Nearly every free or open-source software package available for Linux generally is available for Linux on System z, including Apache HTTP Server, Samba software, JBoss, PostgreSQL, MySQL, PHP, Python programming language, Concurrent Versions System (CVS), GNU Compiler Collection (GCC), and Perl, among many others.[12]
Red Hat and SUSE offer mainline support for their distributions running Linux on System z.[13][14] IBM Global Services also offers support contracts, including 24x7 coverage.[15] Some standard Linux software applications are readily available pre-compiled, including popular closed-source enterprise software packages such as WebSphere,[16] DB2[17] and Oracle[18] databases and applications, SAP R/3, SAP ERP,[19] and IBM's Java Developer's Kit (JDK),[20] to name only a few.
Developer resources[edit]
IBM offers resources to developers wishing to target Linux for System z:
- The Linux Test Drive, a free program granting a single Linux on System z virtual machine for 30 days.[21]
- The IBM Systems Application Advantage for Linux (Chiphopper), a developer program to help developers write and publish cross-platform Linux software.[22]
- The Community Development System for Linux on System z (CDSL) program, a platform for providing open source developers a platform for porting to Linux on System z.[23]
- The Linux Remote Development Program, a fee-based extended developer support program.[24]
Linux on System z supports Unicode and ASCII just like any other Linux distribution—it is not an EBCDIC-based operating system.[25] Linux is able to read kernel parameters in EBCDIC; this ability is used in z/VM installations.
Porting Linux applications to Linux on System z is fairly straightforward; issues include endianness (Linux on System z is big-endian) and conversion between 32-bit integers and 31-bit pointers on the s390 architecture.[26]
Programs can be easily cross compiled to z/Architecture binaries on non-mainframe Linux systems.[27]
There are at least three software-based System z mainframe emulators.
- FLEX-ES from Fundamental Software is a commercially offered option.[28]
- The open source Hercules emulator supports Linux on System z (and can even run on Linux on System z itself).
- In 2010, IBM introduced the Rational Developer for System z Unit Test Feature, which provides a restricted use execution environment that can run on X86 hardware. IBM's license terms limit use of the Unit Test Feature to certain application development tasks, not including final pre-production compiling or pre-production testing (such as stress testing). The Unit Test Feature includes z/OS (with common middleware) and is also compatible with Linux on System z.[29]
See also[edit]
- Comparison of Linux distributions
- OpenSolaris for System z
- Linux on Power
- UNIX System Services
- zIIP
- zAAP
- z/TPF
- z/VSE
- ^ Vepstas, Linas. "Linux on the IBM ESA/390 Mainframe Architecture". Retrieved 5 June 2013.
- ^ "Linux/390 - Notes and Observations". Retrieved 5 June 2013.
- ^ "Linux for S/390". Retrieved 5 June 2013.
- ^ "Kernel 2.2 based". developerWorks. IBM. Retrieved 5 June 2013.
- ^ Milberg, Ken. "The Gen Xer's Guide to the Mainframe Part III". IBM Systems Magazine. Retrieved 5 June 2013.
- ^ a b "Porting applications to Linux for System z". developerWorks. IBM. Retrieved 5 June 2013.
- ^ "HiperSockets". z/OS basic skills information center. IBM. Retrieved 5 June 2013.
- ^ "IBM System z: Linux on System z - Solutions - IFL". IBM. Retrieved 5 June 2013.
- ^ "IBM System z: Linux on System z - Resources - Tested platforms". IBM. Retrieved 5 June 2013.
- ^ "S/390 Port". Debian. Retrieved 5 June 2013.
- ^ "Architectures/s390x". Fedora Project. Retrieved 5 June 2013.
- ^ "Debian autobuilder status for s390, 29 April 2013". Debian. Retrieved 5 June 2013.
- ^ "Red Hat Enterprise Linux for IBM System z". Red Hat. Retrieved 5 June 2013.
- ^ "SUSE Linux Enterprise Server for System z". SUSE. Retrieved 5 June 2013.
- ^ "IBM Services and Support for Linux". IBM. Retrieved 5 June 2013.
- ^ "WebSphere MQ for Linux for System z". IBM. Retrieved 5 June 2013.
- ^ "Installation requirements for DB2 servers and IBM data server clients (Linux)". IBM DB2 Version 10.1 Information Center. IBM. Retrieved 5 June 2013.
- ^ "IBM System z: Linux on System z - Solutions - zSolution Oracle - Overview". IBM. Retrieved 5 June 2013.
- ^ "SAP Applications Empower Business". Retrieved 5 June 2013.
- ^ "developerWorks : Technical Topics : Java™ technology : IBM Developer kits : Linux : Download information". Retrieved 5 June 2013.
- ^ "Linux Test Drive". IBM. Retrieved 5 June 2013.
- ^ "IBM Systems Application Advantage for Linux (Chiphopper)". IBM. Retrieved 5 June 2013.
- ^ "IBM System z: Linux on System z - Community Development System for Linux - Registration Form". IBM. Retrieved 5 June 2013.
- ^ "Linux Remote Development Program". IBM. Retrieved 5 June 2013.
- ^ "Mainframe operating system: Linux for System z". z/OS basic skills information center. IBM. Retrieved 5 June 2013.
- ^ Gellerich, Wolfgang. "Porting applications to Linux for System z". IBM developerWorks. IBM. Retrieved 23 October 2013.
- ^ "How to". IBM developerWorks. Retrieved 23 October 2013.
- ^ "System/390 on Intel-Based Servers". Retrieved 5 June 2013.
- ^ "Rational System z Development and Testing Hub". IBM. Retrieved 5 June 2013.
External links[edit]
- Linux on System z
- Linux on z/VM
- Linux on System z developer site
- Linux for S/390 and zSeries community wiki
- Linux for S/390 and zSeries web site
- linux-390, users mailing list.
- linux-s390, kernel devel mailing list.
- IBM Software for Linux
- IBM Redbooks for Linux on System z technical know-how
- Virtualization Cookbooks for Red Hat Enterprise Linux (RHEL) and SUSE Linux Enterprise Server (SLES).
- Linux Technology Center at IBM
- Porting GCC to the IBM S/390 platform


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Prejudice is a feeling of dislike towards someone or something. It is a feeling of supremacy over someone who is different. I feel that prejudice is a bad way to look at someone of a different race. It is a bad way to treat a person that is of a different race. Prejudice is racism. Prejudice is wrong. Prejudice happened a lot up until 1964. They used to segregate people of a different race at schools, diners, and even drinking fountains.
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Corvos: from Lisbon, Portugal Taking classical string instruments and beautifully transforming them in the name of rock music, Corvos is molding a unique yet familiar sound. It is a sound that embodies the boldness of an orquestra and the energy and passion of rock and roll. The band's influences include genre defining musicians such as […]


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Chilli Says Usher Was Her First 'Real Love,' Details Relationship
There's been plenty of great albums inspired by broken relationships: a good portion of Eminem's 'Marshall Mathers LP,' Marvin Gaye's 'Here, My Dear' and Nas' 'Life Is Good.' For a while, Usher's diamond-selling 'Confessions' was thought to belong in that line of projects. TLC's Rozonda "Chilli" Thomas says that's not the case.
ICYMI: Aloe Blacc Announces New Album, Cassie Dyes Her Hair + More
News you may have missed courtesy of our sister site The Drop:
Aloe Blacc is enjoying some success thanks to his new single with producer Avicii and the soul singer just announced that he has a third full-length on the way.
Cassie decided that it's time for a change and is going with a bold and more importantly blue new hairstyle. Oh, and sh
ICYMI: Usher's Son Injured, A$AP Ferg Previews Album + More
Usher to Curate Music for Macy's July 4th Fireworks Show in NYC
Lil Wayne Tweets From Hospital — 'I'm Good Everybody'
Lil Wayne is alive!
Following reports that he'd been suffering from life-threatening seizures, he -- or someone claiming to be him -- sent out an update on his Twitter account at around 9:30 PM Friday night (March 15).
"I'm good everybody," he wrote. "Thx for the prayers and love.
Previously, it was reported that Wayne was in a medical induced coma and needed to have his stomach pumped to re
Nicki Minaj Tweets Bikini Pics, Usher, The-Dream Drop New Songs & More
Happy Valentine's Day boys and girls. Here's Nicki Minaj's contribution, a collection of pictures she tweeted of herself in a bikini, with the hashtags "Happy #VagDay boyz... #JerkResponsibly."
Outta nowhere, Usher has dr
Usher, Grammys 2013: 'Climax' Wins Best R&B Performance
Usher's "Climax" won the award for Best R&B Performance at the 2013 Grammy Awards.
He beat out Estelle's "Thank You;" Miguel's "Adorn;" Luke James' "I Want You" and Robert Glasper Experiment's "Go
President Obama Inauguration: Usher, Alicia Keys, Stevie Wonder & More to Perform
WASHINGTON (AP) - President Barack Obama is drawing an A-list of performers for his inaugural festivities, including a massive ball expected to draw more than 35,000 revelers.
Katy Perry, Smokey Robinson, Usher, Alicia Keys an


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Situated on 3 acres on one of the most sought after streets in Albuquerque, this Tuscan Estate is nestled in the Cottonwoods surrounded by lavish grounds. Spectacular in every respect, the workmanship of this exquisite home emanates precision and quality and blends Old World craftsmanship with modern technology. Boasting full solar (15kw) and a complete Apple Based Smart House System. Truly an entertainer's masterpeice with a spectacular outdoor pool pavilion. A rare and truly special offering
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17 Meetup Groups match "Computer Science" near Golden, CO
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This is a University of Colorado sponsored group for anyone interested in high performance computing.
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For folks who desire to have fun playing with data and develop both strong technical ability and skills to apply data science and analytic results to critical business issues. A data scientist is somebody who can play with data, spot trends and learn truths few others know. Data scientists are inquisitive: exploring, asking questions, doing "what if" analysis, questioning existing assumptions and processes. Data Science: the analysis of data creation. The data scientist has a solid foundation in …
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Signal-to-Noise Audio Labs is an interdisciplinary R&D group that makes cool stuff. We're scientists, artists, engineers and everything in between that come together to research, design, develop, perform with, and teach innovative media technologies. Some of the disciplines draw from: Physics Music Acoustics Psychoacoustics Electrical & Mechanical Engineering Audio Engineering Cognitive Sciences Computer Sciences Mathematics Industrial Design And so much more! The group was founded with an aud …
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This group is for people along the Colorado Front Range who are interested in the real NLP, i.e. Natural Language Processing. Topics may include (but are not limited to) computational linguistics, machine learning, information retrieval, and text analytics. If you are actively involved in NLP or just want to learn more, please join us.
This social group is for those who would like to meet people of calm and quiet personality who enjoy discussing intellectual topics in a collected manner. Smart and intuitive chicks and dudes with an open minded sense of humor of any nationality and in their 20s and 30s, or thereabout, are highly encouraged to join. The word 'social' often conjures others words like extroverted, loud, busy, popular for which there are many meetup groups already filling this role. As such, this group aims to attr …
(This is a clone of the original NYC meetup) If you've ever visited Hacker News, you've almost certainly seen the "Show HN" or "Ask HN" posts. Well, it's time to get off the Internet and tell us about it face to face. We'll provide you with our honest feedback, you provide us with a great hack, or idea. We'll give you 5 minutes to show off your tool, hack, library (did you just write a library to access the Meetup API in Go!?), whatever. We're language and software/hardware agnostic, so it's all …
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The Colorado Robotics Association brings together researchers, engineers, and scientists from industry, academia, and commercial institutions fostering growth and an awareness of the robotics industry in Colorado. We host regular meetings to enable the sharing of information and skills that are critical to the growing Colorado robotics industry.
Hello Fellow Web Techs, Whether you're at the office haggling with the server company or at home writing code in your underwear...we all could use an excuse to get out and grab a beer. And what better place to make business connections and swap cards than a happy hour! The Denver-Metro Web Techs Happy Network Hour was hatched to boost the spirit and careers of our community of web friends. What's Happening - We meet the 3rd Thursday of every month, alternating between Denver & the DTC a …
Our meetup is designed to bring together all of the R users along the Front Range of Colorado. We welcome R newbies as well as the experience hacker. All backgrounds are encouraged to join the group -- life sciences, social sciences, etc.
SHARC is one of the most active hands-on technology clubs in Colorado. We are active in STE(A)M education and our members have mentored numerous FIRST and BEST teams in the Greater Denver Area. We created and sponsor the Annual Robotics at the Hangar with Wings Over the Rockies Air & Space Museum in Lowry. We work with United Launch Alliance mentoring payload teams for their Annual Intern Rocket Launch in Pueblo. Our members have participated and medalled in the SparkFun Autonomous Vehicle Compe …
Every want a place where you can find the tools you need and, maybe, a group of people that know how to do interesting stuff and have amazing madskills that you can collaborate with to create new and wonderful things? Yea... us too. We want to put together a place like that in Longmont. This would be a place where art, technology, tools, teaching and collaboration come together into a true creative community. What's often been called a Hackerspace or Makerspace in other cities with similar space …
Analyze Boulder is a community of data geeks who live, work, and play in Boulder, Colorado. Check out our blog!
Meet other futurists and talk about the accelerating change in technology, science, society, business. Some examples of topics we discuss are: quantum computing, global warming and future climate change, peak oil and future energy, the future of religion, the future of entertainment, future wars, language translation, nanotechnology, and artificial intelligence. Meetings are the 4th friday of each month at Boulder Book Store on Pearl Street. Our website is http://www.boulderfuture.org/
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Discussions, group coding, and talks on Storm/Trident, and other examples of distributed realtime complex event processing systems.
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NumPy, SciPy, Pandas, Matplotlib, nltk and more. We think Python is the leading language for data analysis, and it's quickly getting even better. Join us to meet other PyData enthusiasts and learn from our experience.
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Offered by the Rocky Mountain Oracle Users Group (RMOUG) and Regis University School of Computer & Information Sciences (SCIS). Each meeting features hands-on labs using the latest Oracle database technologies, products, features, and utilities at a local Regis campus. Format includes: lecture, lab, Q&A, and attendee networking.
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LadyCoders Mission: Foster a community of mentorship by providing career guidance for women in technology. Our Goals include: Help women manage their careers. Form a community of mentorship. Increase the number of women in technical positions. Narrow the salary gap. Provide confidence and inspiration. Provide solid career advice and guidance for every aspect of their career. Get women kick-ass jobs in tech.
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Friday 13 December 2013
66. Valparaiso, Chile
There is something about this Chilean port town. On the face of it, its slightly dilapidated air, chaotic mish-mash of electrical wires, and gangs of stray cats and dogs do not make for a magical travel experience. But while not everyone falls under the town's spell, many still do – and they are in good company. The Chilean poet Pablo Neruda had his house in the city, which he nicknamed his House in the Air for its perch over the sinuous, hilly streets of the town. There remains something poetic about the twisting alleys, the colourful clapboard houses, and the troubadours that ply the town's many bars and cafes.
Read more Pablo Neruda's Chila
Cheaper alternative? Colourful houses can be found around Tenby harbour, in Cork, and on the Scottish island of Mull.
Places to see before the world ends: 100-81
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Met Live in HD: Palace 9
- Saturday, March 27, 1PM;
- Wednesday, April 14, 6:30PM
at Palace 9 Cinemas in South Burlington. $20-24.
Contact Info:
- 802-660-9300
- Event Website
Seven Days Says:
Simon Keenlyside stars in the high-def broadcast of the Metropolitan Opera's production of Ambroise Thomas' dark opera Hamlet.


text: We went to local flavor on our Eureka Springs vacation recently. We went on a weeknight during off season so there was no wait. We had excellent service. The waitress was also very knowledgable about the menu options. On her recommendation, I went with the sweet and spicy shrimp dish. It was incredible. We had the spinach artichoke dip as... More


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Chronic myelogenous leukemia
Chronic myelogenous leukemia | |
Classification and external resources | |
The Philadelphia chromosome as seen by metaphase FISH.
DiseasesDB | 2659 |
MedlinePlus | 000570 |
eMedicine | med/371 |
MeSH | D015464 |
Chronic myelogenous (or myeloid) leukemia (CML), also known as chronic granulocytic leukemia (CGL), is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which a proliferation of mature granulocytes (neutrophils, eosinophils and basophils) and their precursors is found. It is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome. CML is now largely treated with targeted drugs called tyrosine kinase inhibitors (TKIs), such as Gleevec/Glivec (imatinib), Sprycel (dasatinib), Tasigna (nilotinib), Iclusig (ponatinib), or Bosulif (bosutinib) which have led to dramatically improved long term survival rates (95.2%) since the introduction of Gleevec in 2001. These drugs have revolutionized treatment of this disease and allow most patients to have a good quality of life when compared to the former chemotherapy drugs.
Signs and symptoms[edit]
Patients are often asymptomatic at diagnosis, presenting incidentally with an elevated white blood cell count on a routine laboratory test. In this setting, CML must be distinguished from a leukemoid reaction, which can have a similar appearance on a blood smear. Symptoms of CML may include: enlarged spleen causing pain on the left side, malaise, joint and/or hip pain, low-grade fever, increased susceptibility to infections, anemia, and thrombocytopenia with easy bruising (although an increased platelet count (thrombocytosis) may also occur in CML).[1][2]
CML is often suspected on the basis of a complete blood count, which shows increased granulocytes of all types, typically including mature myeloid cells. Basophils and eosinophils are almost universally increased; this feature may help differentiate CML from a leukemoid reaction. A bone marrow biopsy is often performed as part of the evaluation for CML, and CML is diagnosed by detecting the Philadelphia chromosome. This characteristic chromosomal abnormality can be detected by routine cytogenetics, by fluorescent in situ hybridization, or by PCR for the bcr-abl fusion gene.[2]
Controversy exists over so-called Ph-negative CML, or cases of suspected CML in which the Philadelphia chromosome cannot be detected. Many such patients in fact have complex chromosomal abnormalities that mask the (9;22) translocation, or have evidence of the translocation by FISH or RT-PCR in spite of normal routine karyotyping.[3] The small subset of patients without detectable molecular evidence of bcr-abl fusion may be better classified as having an undifferentiated myelodysplastic/myeloproliferative disorder, as their clinical course tends to be different from patients with CML.[4]
CML was the first malignancy to be linked to a clear genetic abnormality, the chromosomal translocation known as the Philadelphia chromosome. This chromosomal abnormality is so named because it was first discovered and described in 1960 by two scientists from Philadelphia, Pennsylvania, USA: Peter Nowell of the University of Pennsylvania and David Hungerford of Fox Chase Cancer Center.[5]
In this translocation, parts of two chromosomes (the 9th and 22nd by conventional karyotypic numbering) switch places. As a result, part of the BCR ("breakpoint cluster region") gene from chromosome 22 is fused with the ABL gene on chromosome 9. This abnormal "fusion" gene generates a protein of p210 or sometimes p185 weight (p210 is short for 210 kDa protein, a shorthand used for characterizing proteins based solely on size). Because abl carries a domain that can add phosphate groups to tyrosine residues (a tyrosine kinase), the bcr-abl fusion gene product is also a tyrosine kinase.[1][6]
The fused BCR-ABL protein interacts with the interleukin 3beta(c) receptor subunit. The BCR-ABL transcript is continuously active and does not require activation by other cellular messaging proteins. In turn, BCR-ABL activates a cascade of proteins that control the cell cycle, speeding up cell division. Moreover, the BCR-ABL protein inhibits DNA repair, causing genomic instability and making the cell more susceptible to developing further genetic abnormalities. The action of the BCR-ABL protein is the pathophysiologic cause of chronic myelogenous leukemia. With improved understanding of the nature of the BCR-ABL protein and its action as a tyrosine kinase, targeted therapies (the first of which was imatinib mesylate) that specifically inhibit the activity of the BCR-ABL protein have been developed. These tyrosine kinase inhibitors can induce complete remissions in CML, confirming the central importance of bcr-abl as the cause of CML.[6]
CML is often divided into three phases based on clinical characteristics and laboratory findings. In the absence of intervention, CML typically begins in the chronic phase, and over the course of several years progresses to an accelerated phase and ultimately to a blast crisis. Blast crisis is the terminal phase of CML and clinically behaves like an acute leukemia. Drug treatment will usually stop this progression if started early. One of the drivers of the progression from chronic phase through acceleration and blast crisis is the acquisition of new chromosomal abnormalities (in addition to the Philadelphia chromosome).[1] Some patients may already be in the accelerated phase or blast crisis by the time they are diagnosed.[2]
Chronic phase[edit]
Approximately 85% of patients with CML are in the chronic phase at the time of diagnosis. During this phase, patients are usually asymptomatic or have only mild symptoms of fatigue, left side pain, joint and/or hip pain, or abdominal fullness. The duration of chronic phase is variable and depends on how early the disease was diagnosed as well as the therapies used. In the absence of treatment, the disease progresses to an accelerated phase.[2]
Accelerated phase[edit]
Criteria for diagnosing transition into the accelerated phase are somewhat variable; the most widely used criteria are those put forward by investigators at M.D. Anderson Cancer Center,[7] by Sokal et al.,[8] and the World Health Organization.[4][9] The WHO criteria are perhaps most widely used, and define the accelerated phase by any of the following:
- 10–19% myeloblasts in the blood or bone marrow
- >20% basophils in the blood or bone marrow
- Platelet count <100,000, unrelated to therapy
- Platelet count >1,000,000, unresponsive to therapy
- Cytogenetic evolution with new abnormalities in addition to the Philadelphia chromosome
- Increasing splenomegaly or white blood cell count, unresponsive to therapy
The patient is considered to be in the accelerated phase if any of the above are present. The accelerated phase is significant because it signals that the disease is progressing and transformation to blast crisis is imminent. Drug treatment often becomes less effective in the advanced stages.[4]
Blast crisis[edit]
Blast crisis is the final phase in the evolution of CML, and behaves like an acute leukemia, with rapid progression and short survival.[2] Blast crisis is diagnosed if any of the following are present in a patient with CML:[10]
- >20% myeloblasts or lymphoblasts in the blood or bone marrow
- Large clusters of blasts in the bone marrow on biopsy
- Development of a chloroma (solid focus of leukemia outside the bone marrow)
This section requires expansion. (August 2012) |
Chronic phase[edit]
In the past, antimetabolites (e.g., cytarabine, hydroxyurea), alkylating agents, interferon alfa 2b, and steroids were used as treatments of CML in the chronic phase, but since the 2000s have been replaced by TK inhibitor[11] drugs that specifically target BCR-ABL, the constitutively activated tyrosine kinase fusion protein caused by the Philadelphia chromosome translocation. IRIS, an international study that compared interferon/cytarabine combination and the first of these new drugs imatinib, with long-term follow up, demonstrated the clear superiority of TK-targeted inhibition over existing treatments. Bone marrow transplantation was also used as initial treatment for CML before the advent of imatinib, but is now used less often, and primarily for those who fail drug treatment. While transplantation can often be curative, the rate of transplant-related mortality, though improving, now makes use of the option more limited.[citation needed]
The first of this new class of drugs was imatinib mesylate (marketed as Gleevec or Glivec), approved by the U.S. Food and Drug Administration (FDA) in 2001. Imatinib was found to inhibit the progression of CML in a the majority of patients (65–75%) sufficiently to achieve regrowth of their normal bone marrow stem cell population (a cytogenetic response) with stable proportions of maturing white blood cells. Because some leukemic cells (as evaluated by RT-PCR) persist in nearly all patients, the treatment has to be continued indefinitely. Since the advent of imatinib, CML has become the first cancer in which a standard medical treatment may give to the patient a normal life expectancy.[12]
Dasatinib and nilotinib[edit]
To overcome imatinib resistance and to increase responsiveness to TK inhibitors, two novel agents were later developed. The first, dasatinib, blocks several further oncogenic proteins, in addition to more potent inhibition of the BCR-ABL protein, and was initially approved in 2007 by the US FDA to treat CML in patients who were either resistant to or intolerant of imatinib. A second new TK inhibitor, nilotinib, was also approved by the FDA for the same indication. In 2010, nilotinib and dasatinib were also approved for first-line therapy, making three drugs in this class available for treatment of newly diagnosed CML.
Treatment-resistant CML[edit]
Whilst capable of producing significantly improved responses compared with the action of imatinib, neither dasatinib nor nilotinib could overcome drug resistance caused by one particular mutation found to occur in the structure of BCR-ABL known as the T315I mutation. Two approaches were developed to the treatment of CML as a result.
In 2007, Chemgenex released results of an open-label Phase 2/3 study (CGX-635-CML-202) that investigated the use of a non BCR-ABL targeted agent omacetaxine, administered subcutaneously in patients who had failed with imatinib and exhibited T315I kinase domain mutation.[13][14] This is a study which is ongoing through 2014.[15] In September 2012,the FDA approved omacetaxine for the treatment of CML in the case of resistance to other chemotherapeutic agents.[16][17]
Independently, ARIAD pharmaceuticals, adapting the chemical structures from first and second-generation TK inhibitors, arrived at a new pan-BCR-ABL inhibitor which showed (for the first time) efficacy against T315I, as well as all other known mutations of the oncoprotein. The drug, Ponatinib, gained FDA approval in December 2012 for treatment of patients with resistant or intolerant CML. Just as with second generation TK inhibitors, early approval is being sought to extend the use of Ponatinib to newly diagnosed CML also.[citation needed]
In 2005, encouraging but mixed results of vaccination were reported with the BCR/abl p210 fusion protein in patients with stable disease, with GM-CSF as an adjuvant.[18]
A follow-up on patients using imatinib published in the New England Journal of Medicine in 2006 showed an overall survival rate of 89% after five years.[19] In 2011, an independent study performed in 832 CML patients worldwide reported that the group of patients who achieve a stable cytogenetic response with imatinib shows an overall survival rate of 95.2% after 8 years, which is similar to the rate in the general population. Only 1% of patients died because of leukemia progression.[12]
CML occurs in all age groups, but most commonly in the middle-aged and elderly. Its annual incidence is 1–2 per 100,000 people, and slightly more men than women are affected. CML represents about 15–20% of all cases of adult leukemia in Western populations.[1] The only well-described risk factor for CML is exposure to ionizing radiation;[citation needed] for example, increased rates of CML were seen in people exposed to the atomic bombings of Hiroshima and Nagasaki[20]
Leukemia is also rarely associated with pregnancy, affecting only about 1 in 10,000 pregnant women.[21][22] Chronic myelogenous leukemia can be treated with relative safety at any time during pregnancy with Interferon-alpha hormones.[21]
- ^ a b c d Faderl S, Talpaz M, Estrov Z, Kantarjian HM (1999). "Chronic myelogenous leukemia: biology and therapy". Annals of Internal Medicine 131 (3): 207–219. PMID 10428738.
- ^ a b c d e Tefferi A (2006). "Classification, diagnosis and management of myeloproliferative disorders in the JAK2V617F era". Hematology Am Soc Hematol Educ Program 2006: 240–5. doi:10.1182/asheducation-2006.1.240. PMID 17124067.
- ^ Savage DG; Szydlo RM; Goldman JM (1997). "Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period". Br J Haematol 96 (1): 111–6. doi:10.1046/j.1365-2141.1997.d01-1982.x. PMID 9012696.
- ^ a b c Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, Barosi G, Verstovsek S, Birgegard G, Mesa R, Reilly JT, Gisslinger H, Vannucchi AM, Cervantes F, Finazzi G, Hoffman R, Gilliland DG, Bloomfield CD, Vardiman JW (2007). "Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert pane". Blood 110 (4): 1092–7. doi:10.1182/blood-2007-04-083501. PMID 17488875.
- ^ Nowell PC (2007). "Discovery of the Philadelphia chromosome: a personal perspective". Journal of Clinical Investigation 117 (8): 2033–5. doi:10.1172/JCI31771. PMC 1934591. PMID 17671636.
- ^ a b Hehlmann R, Hochhaus A, Baccarani M; European LeukemiaNet (2007). "Chronic myeloid leukaemia". Lancet 370 (9584): 342–50. doi:10.1016/S0140-6736(07)61165-9. PMID 17662883.
- ^ Kantarjian H, Dixon D, Keating M, Talpaz M, Walters R, McCredie K, Freireich E (1988). "Characteristics of accelerated disease in chronic myelogenous leukemia". Cancer 61 (7): 1441–6. doi:10.1002/1097-0142(19880401)61:7<1441::AID-CNCR2820610727>3.0.CO;2-C. PMID 3162181.
- ^ Sokal J, Baccarani M, Russo D, Tura S (1988). "Staging and prognosis in chronic myelogenous leukemia". Semin Hematol 25 (1): 49–61. PMID 3279515.
- ^ Vardiman J, Harris N, Brunning R (2002). "The World Health Organization (WHO) classification of the myeloid neoplasms". Blood 100 (7): 2292–302. doi:10.1182/blood-2002-04-1199. PMID 12239137. Retrieved 2007-09-22.
- ^ Karbasian Esfahani M, Morris EL, Dutcher JP, Wiernik PH (2006). "Blastic phase of chronic myelogenous leukemia". Current Treatment Options in Oncology 7 (3): 189–199. doi:10.1007/s11864-006-0012-y. PMID 16615875.
- ^ Kufe DW; Pollack RE; Weichselbau RR et al., eds. (2003). "Tyrosine Kinase Inhibitors: Targeting Considerations". Holland-Frei Cancer Medicine (NCBI bookshelf book) (6th ed.). Hamilton, Ontario: BC Decker. ISBN 1-55009-213-8. Retrieved October 27, 2012
- ^ a b Gambacorti-Passerini, C.; Antolini, L.; Mahon, F. -X.; Guilhot, F.; Deininger, M.; Fava, C.; Nagler, A.; Della Casa, C. M.; Morra, E.; Abruzzese, E.; d'Emilio, A.; Stagno, F.; Le Coutre, P.; Hurtado-Monroy, R.; Santini, V.; Martino, B.; Pane, F.; Piccin, A.; Giraldo, P.; Assouline, S.; Durosinmi, M. A.; Leeksma, O.; Pogliani, E. M.; Puttini, M.; Jang, E.; Reiffers, J.; Valsecchi, M. G.; Kim, D. -W. (2011). "Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated with Imatinib". JNCI Journal of the National Cancer Institute 103 (7): 553–561. doi:10.1093/jnci/djr060. PMID 21422402.
- ^ Jabbour, E.; Cortes, J. E.; Giles, F. J.; O'Brien, S.; Kantarjian, H. M. (2007). "Current and emerging treatment options in chronic myeloid leukemia". Cancer 109 (11): 2171–2181. doi:10.1002/cncr.22661. PMID 17431887.
- ^ Kimura, S.; Ashihara, E.; Maekawa, T. (2006). "New tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia". Current pharmaceutical biotechnology 7 (5): 371–379. doi:10.2174/138920106778521532. PMID 17076652.
- ^ "Homoharringtonine (Omacetaxine Mepesuccinate) in Treating Patients With Chronic Myeloid Leukemia (CML) With the T315I BCR-ABL Gene Mutation". ClinicalTrial.gov (database recprd). Retrieved October 27, 2012
- ^ FDA approves Synribo for chronic myelogenous leukemia (press release). U.S. Food and Drug Administration. October 26, 2012. Retrieved October 27, 2012
- ^ FDA approves new orphan drug for chronic myelogenous leukemia (press re;ease). U.S. Food and Drug Administration. September 4, 2012. Retrieved October 27, 2012
- ^ Bocchia, M.; Gentili, S.; Abruzzese, E.; Fanelli, A.; Iuliano, F.; Tabilio, A.; Amabile, M.; Forconi, F.; Gozzetti, A.; Raspadori, D.; Amadori, S.; Lauria, F. (2005). "Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: A multicentre observational trial". The Lancet 365 (9460): 657–662. doi:10.1016/S0140-6736(05)17945-8. PMID 15721470.
- ^ Druker BJ, Guilhot F, O'Brien SG et al. (2006). "Five-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid Leukemia". New England Journal of Medicine 355 (20): 2408–17. doi:10.1056/NEJMoa062867. PMID 17151364.
- ^ Moloney WC (1987). "Radiogenic leukemia revisited". Blood 70 (4): 905–8. PMID 3477299.
- ^ a b Shapira T, Pereg D, Lishner M (September 2008). "How I treat acute and chronic leukemia in pregnancy". Blood Rev. 22 (5): 247–59. doi:10.1016/j.blre.2008.03.006. PMID 18472198.
- ^ Menezes J, et al. (June 2008). "Occurrence of Acute Myeloid Leukemia in Young Pregnant Women". Clinical Medicine: Blood Disorders 1: 27–31. doi:10.4137/CMBD.S823., Occurrence of 1 case of AML per 75,000 pregnancies
External links[edit]
- 50th Anniversary Symposium of Discovery (US)
- The National CML Society (US)
- CMLeukemia
- Chronic Myeloid Leukemia at American Cancer Society
- CML information from The Leukemia & Lymphoma Society
- Chronic Myelocytic Leukemia (CML) at Merck Manual of Diagnosis and Therapy Home Edition
- SPIRIT 2 Website


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I work in Hospitality and am fairly well-traveled. The staff at the Magic Reef couldn't be more friendly or welcoming. The bungalows were spacious and it was easy to save some money by cooking our own meals. The location was perfect for us: a beautiful, uncrowded beach with a view of the sunset. Our only regret is that we couldn't... More
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- Official Description (provided by the hotel):
- The newly built 8 Polynesian style self-contained bungalows are located right on the beach of Arorangi, with golden sunset views from each bungalow. All bungalows have sea views, romantic four poster kingsize beds, private outdoor shower/bath, a/c and ceiling fan, home entertainment. The boat-shaped pool with a unique sail, BBQ facilities and a Petanque course invite to relax. Complimentary airport transfers and breakfast on arrival. ... more less
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Any comparisons of Mr. Smyth & Triple H will result in... www.bsentertainments.co.uk
Originally Posted by Dennis You and your lawyer stay away from my manhood!
IWA Revolution Creative Team WWE/IWA/RTE Originally Posted by VanHooliganX Friendly reminder that Ashley is fucking awesome.
Originally Posted by Robstar I just wanna say.....John Cena heel turn. It's coming.
Want to hate on bunnies!? Originally Posted by NiallF96 Ah Dennis, the kind hearted veteran of e-fedding... #TeamBunnies
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Secrets Sanctuary Cap Cana Opens New Luxury Spa
Filed under: Luxury Travel & Hotels, Spas
The design of the spa sets a restful tone with the use of rich materials like natural stone and wood and hand-made blown glass chandeliers. Treatment highlights include the Myoxy-Caviar High Performance Facial with pure caviar pearl and a blend of phyto extracts; the Tropical Oasis Body Wrap which uses mango and passion fruit extracts for smoother, firmed and vividly brighter skin; and Sabai Mineral Therapy that blends micronized minerals of malachite and zincite with the guest's choice of neroli, lavender and rosemary essential oils to stimulate blood and lymphatic circulation.
The nine treatment rooms, inclusive of 13 massage tables and two treatment tubs, are divided between the main spa building (three) and exterior private spa suites (six). The spa's thermal hydrotherapy circuit consists of a sauna and steam bath, cold rain showers, whirlpool bath, cold plunge bath, swimming pool with cascading waterfalls and a tubular air lounger.
Secrets Sanctuary Cap Cana offers guests 14 different suite categories, an array of dining options, 24-hour room and concierge services, pool and beach wait service, activities and live evening entertainment. The resort has a variety of special offers including girlfriend getaways and golf packages.


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Better parts... better prices, everyday on auto parts and accessories. Plus find a store, check out our current ad, get information on racing events, contact us, and more.
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Hey everyone,
A few months ago I posted about the below issue, but with no luck on a resolution. I was hoping that recent updates to MM would resolve this but to no avail.
The issue I'm having is this: I cannot successfully stream MP3s from MM to my PS3. I am getting error 80710091 followed closely by error 80710004.
The song I am playing is 2:46 long. At about the 1:45 mark, I get error 80710091 and then error 80710004. The song continues to play for about 20 seconds more and then just stops. The PS3 returns me to my song listing. It doesn't really matter what song I try - I still get the same results - a cutoff song.
I believe I have port forwarding set up correctly. I think I have the default auto-conversion rules in place, and all of my songs are in mp3 format. Are there other auto-conversion rules that I need to apply?
My PS3 is using a wired connection to my router, via MOCA, but I've had no problems streaming movies via MOCA from an old Popcorn Hour box nor do I have issues streaming movies from Amazon on my ps3.
On the UPnP/DLNA Server tab, it looks like it sees my PS3 correctly. The Status shows 'Accepted'.
I have not tried seeing if PS3 Media Server will play the song correctly as of this posting, but I am currently downloading it and will try it next here, in a few minutes.
This is the one feature of MM that is not currently working but gets me very excited at the idea that it could work. Does anyone have any ideas for me? I'd really appreciate any help anyone can give.


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Synopsis: Four brothers look to avenge their mother's death.
Supporting actors: Andr? Benjamin, Garrett Hedlund, Terrence Howard, Josh Charles, Sof?a Vergara, Fionnula Flanagan, Chiwetel Ejiofor, Taraji P. Henson, Jernard Burks, Kenneth Welsh, Tony Nappo, Shawn Singleton, Reiya West Downs, Riele West Downs, Lyriq Bent, Richard Chevolleau, Awaovieyi Agie, Shomari Downer, Mpho Koaho, Costin Manu
Directed by: John Singleton
Genre: Action, Crime, Drama, Mystery, Thriller
Runtime: 1 hour 49 minutes
Captions and Subtitles: English
Release year: 2005
Studio: Paramount
MPAA Rating: Rated R for strong violence, pervasive language and some sexual content
Rights & Requirements
Rental rights: 48 hours viewing period. Details
Purchase rights: Stream instantly and download to 2 locations. Details
Format: Amazon Instant Video (streaming online video and digital download)


text: Carine Rag TradeBy Dodai Stewart PO Edit134L André Leon Talley Plans to Save Late Night TV From DreckitudeRaise your hand if you would watch the hell out of a late-night talk show hosted by André Leon Talley. All of your hands had better be up! The man who coined the term drekitude has inked a deal with production company to develop such a show: Read… 2/05/13 1:50pm 2/05/13 1:50pmCalvin Klein's Super Bowl Debut: 97% Abs, 3% UnderwearLady Gaga's Stylist Goes On The Defensive


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Highlights: Argentina (Buenos Aires) , Antarctica Cruises (Antarctic Cruise)
Discover Buenos aires with your private guide, before you experience the planet's last untouched continent from one of the most advanced expedition ships ever built. This voyage will take you through the renowned stretch of the Drake Passage, escorted by albatrosses and storm petrels, before arriving at the magical white landscape of Antarctica. You will experience the continent in summer with its incredible wildlife including seals, penguins and whales. Make landings on small expedition skiffs to explore the landscape and animals in a more intimate way than ever imagined. A true once-in-a-lifetime journey.
Cruise Departure Dates: 2013: Nov 22 2014: Jan 4, Jan 13, Feb 15, Nov 19* 2015: Jan 4*, Jan 16* *indicates extended 13-night version of cruise
A private transfer between the airport (International) and city of Buenos Aires with a professional driver and an English-speaking guide is provided.
Loi Suites Recoleta is located in the most elegant area of the city, at walking distance from museums, art galleries and shopping areas, historical architecture and beautiful parks. A tropical Winter Garden with swimming pool and restaurant complete the relaxing atmosphere anyone would wish for in an upscale hotel. International cuisine is also served in La Fuente restaurant, intimate and warm.
The recently discovered ancient tunnels of Buenos Aires are one of the city's best kept secrets. Enjoy a private half day city tour including a visit of the ancient passages and get to know Buenos Aires from the ground up. After meeting your private guide (with driver and private vehicle) at the hotel, you'll visit the Plaza de Mayo, the city's founding site and genuine starting point of Buenos Aires' urban development. Next is San Telmo, a former enclave for local aristocracy. This charming colonial district, with its cobbled streets, has many artists' studios and is one of the trendiest neighborhoods of the city. In San Telmo lies a recently unearthed treasure: the ancient subterranean tunnels. The construction of tunnels started in the colonial era, and continued well into the 19th century. From ancient times, many myths have been created around the tunnels: people said they witnessed secret encounters, disappearances, murders or even political conspiracies.Enjoy visiting one of these tunnels, a part of a 3,000 square meter labyrinth below the streets of San Telmo, made up of a long corridor with vaulted ceilings and display cabinets exhibiting many items and utensils recovered during the excavation. Other areas that are included in your tour include La Boca, (which was strongly shaped by the working class Italian immigrants, with its make shift houses made from scrap materials found in local shipyards), Puerto Madero - Buenos Aires' latest and most sophisticated neighborhood, and La Recoleta, where a short stop is made at the gorgeous Plaza San Martín, the Basílica de Nuestra Señora del Pilar, (the city's second oldest church), and the celebrated Recoleta Cemetery, an imposing labyrinth of ornate graves and mausoleums where some of the most important characters of Argentina's political and cultural life (including Eva Peron) are buried. The last stop on the tour is at the area known as Palermo Woods. Next to the woods lie the splendid palaces built by the wealthy classes in the early 20th century to rival with Paris. After having gained deep insight in this culturally rich city, you will return to our hotel.
A private airport transfer with a professional driver and English-speaking guide is included (between Buenos Aires' hotels and domestic airport or vice versa)
Fly from Buenos Aires domestic airport to Ushuaia. Note flights are subject to changes based on availability. The flight duration is approximately 3.5 hour.
Upon arrival, you'll have a few hours at leisure in Ushuaia, the southernmost town in the world, before an included excursion to Ushuaia National Park. On this guided coach excursion, you'll see the area's mountains, forests, lagoons, rivers and lakes, as well as the coast of the Beagle Channel. You'll be returned to the port for embarkation after the excursion.
Welcome aboard!Take some time to get settled in to your cabin, and explore the facilities on your ship. Tonight's welcome dinner will offer an ideal opportunity to meet some of your fellow cruisemates.
M/S Fram is named after the ship used by famous Norwegian Explorer Fridtjof Nansen, M/S Fram's interior has been inspired by Greenland and the Arctic region; with a glass-enclosed observation lounge and excellent leisure facilities including a gym, sauna and two heated outdoor Jacuzzis. M/S Fram is a purpose built 12,700-ton vessel that incorporates all the best of both practical and traditional design. Items of the original Fram are also be displayed throughout the vessel, linking the present MS Fram with the rich history of its illustrious past.
You're encouraged to join some of the onboard educational lectures as you begin your journey south to the Antarctic Convergence. Also, keep your eye out for whales, as they can certainly be spotted in these waters.
Named after Sir Francis Drake this stretch of water between South America and the Antarctic Peninsula has numerous myths and legends connected to it. The extraordinary seaworthiness of MS Fram ensures you a safe and comfortable passage.
Once you have crossed the Antarctic Convergence you will start feeling the air getting crisper and colder. You will begin to see Antarctic penguins in the water, and don't forget to be on the lookout for the first iceberg.
There are no permanent human inhabitants but it is home to millions of penguins and the feeding area for thousands of whales. Words simply cannot describe the feeling of being on the Great White Continent. Throughout your time cruising Antarctica, you'll make landings by skiff for exploration.
The ice, wind and weather dictate life in Antarctica, as well as your route. Every voyage is unique and your experienced crew will make all voyages an experience of a lifetime. The final choice of landings will be made in the course of the voyage by your captain.
During the course of your expedition, you'll get some spectactular once-in-a-lifetime photo opportunities. Landings will get you closer to wildlife than you could ever imagine.
As the bow points north you will have time to reflect on your Antarctic experience with its unforgettable sights and sounds.
Today you'll sail the final stretch of the Drake Passage, aka the "Drake Shake", as you set your sights on the land ahead; South America.
After a spectacular voyage with countless impressions, you disembark from your ship at the world's southernmost town before transferring to Ushuaia airport for your charter flight to Buenos Aires.
Fly from Ushuaia to Buenos Aires domestic airport. Not flights are subject to changes based on availability. The flight duration is approximately 3.5 hrs
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text:
Just a warning not to overdo it...
Farfle wrote:No, the X5's are not the same size as the hx axles but yes, they can be pressed out. They are not a splined shaft, you use a linear knurling tool with coarse teeth, I bought this one: http://www.grizzly.com/products/2-pc-Kn ... -Set/H5936
and it held up for about a month until it wore out, but it's 1/10th the cost of a good one.
NeilP wrote:I have been considering a torque plate with a 'metalastic' type fitting, you know what I mean? something to still prevent axle rotation but with enough give in it to take out these shock loadings that are probably a contributing factor on these failures..or just thicker axles I suppose
miro13car wrote:Wondering what would be the cost of such rebuilding of HS/HT motor presuming you don't pay for drawings, charging US$50 labour rate and and material easy US$ 1000 I would say but I think much more maybe 1500.
Only taking such motor apart with Chinese using thread locker compond is a challange and time consuming and their choice of Philips screws for cover is complete ignorance , because standard screw for such application is Allen bolts , well but they cost cents each more.
Machining new axle is only beginning of mods, reboring and replacing bearings is another mod, next replacing halls with quality ones, after that what else
China manufacturing is obssesed with cost savings?
Such modified HT/HS is not exactely cheap anymore,
miro13car wrote:you forgot cooling system with liquid weights also , right?
There something wrong with hub motor needing cooling at even 2000W.
There is something wrong with the motor which simply needs to draw so much power, to much power to reach say 35mph comparing with other motors .
So the question should be why it needs to draw so much to produce?
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The process of buying a new Mercedes-Benz car or truck can seem overwhelming if you don't know where to begin. Edmunds.com can get you started on the right track with a convenient directory of Mercedes-Benz car dealerships in and around Hollywood, Florida. Compare online price quotes on the new or used car, truck, SUV, minivan, or wagon of your choice to locate the best deals. Edmunds.com makes it easy to find trusted Mercedes-Benz car dealers in Hollywood, saving car buyers time and money on what will be an important purchase.
"My wife and I purchased a 2012 MB E350 Coupe on November 24th, 2011, from Mercedes Benz of Pembroke Pines, Florida. Our sales person, David A., was a"... Read more Review by: oceandigger33
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"Had an excellent experience doing the above, from my salesman (Danny K.) to his manager (Herminio P.) to the finance manager (Henry D.). They all work"... Read more Review by: autochemex


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DuPage Stormwater Management expects to use flood control facilities Wednesday night
WHEATON – DuPage County Stormwater Management expects to use its flood control facilities between 9 p.m. and midnight Wednesday, according to a county news release.
In addition to one inch of rain received on Wednesday, the National Weather Service has estimated the DuPage County area could see as many as three inches of rain through Thursday, according to the release.
This rain could cause water levels to rise in Salt Creek and the West Branch DuPage River, leading the county to operate its flood control facilities, including Fawell Dam (Naperville), Spring Creek Reservoir (Bloomingdale), Elmhurst Quarry (Elmhurst) and Wood Dale-Itasca Reservoir (Wood Dale). Other smaller facilities could operate as well.
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About 85 percent of educational institutions allow their teachers or students use […]
by Steve Rendle
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After the closest-fought season in F1 history, Sebastian Vettel became the youngest-ever World Champion. His car, the Red Bull RB6, the work of a team led by legendary F1 designer Adrian Newey, was the envy of the paddock, proving to be consistently faster than its rivals over the season. In this fascinating book, the Red Bull RB6 receives the Haynes Manual treatment, providing an unprecedented insight into the design, technology and engineering of an F1 car as well as the inner workings of Red Bull Racing.
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cynicism of her visual art argues against the easy answers provided by cliché or the recourse to self-improving platitudes, this is the awkward note on which her book ends: 'I have found a way to visit without fear, exorcising all ghosts from the past to fill my mind with something mind-blowing.' Strangeland splits into three parts: Motherland, Fatherland and Traceyland – all variants on a crumbling, melancholy amusement arcade in Margate called Dreamland. Each is composed of fragments of memory, dream, and fantasy, plus snatches of experimental writing on themes such as what it feels like to be pregnant, to get no cards on Valentine's Day, or to dislike food. Motherland, in which Emin's adored mum is an atmosphere rather than anything more solid, begins with Emin's birth ('I somehow felt a mistake had been made') and goes on to give us the childhood with her twin brother on the Margate seafront ('where there was nothing to do but blend in with the general decay: bum around, fuck, be fucked, bum and wish your life away'), the fall from riches to poverty (when her Turkish Cypriot father went bankrupt and the Emins moved from living in his hotel to living in a dump), her sexual abuse and rape as a child, and her leaving school at thirteen. In Fatherland, the figure who was only an atmosphere in her childhood becomes a visceral presence; a boasting, boozing, womanising bar-room bore. Emin's time with him and his family in Turkey is presented in the sepia that abandoned children sometimes reserve for the abandoning parent. The final part of the book, which takes place almost entirely in the bed we know so well, gives us other material with which we are also familiar, like her abortions, anorexia, boozing and promiscuity. It is all part of Traceyland, that odd mix of Tory values and tawdry habits which has chiselled its way into our cultural landscape. Part of Tracey Emin's charm is her lack of formal education, which gives her work a freedom from the burden of the past. It is the sheer banalityof her material, when in the form of a bed or a tent, that makes it an original and provocative contribution to the visual arts. But when she presents her world as a book in a literary tradition that goes back to Saint Augustine, the force of her confessions simply fades away. It is not that Strangelandis insincere in its attempt to deal with an interesting life in an interesting way; on the contrary, its appalling sincerity is what makes it seem so very uninteresting. With Emin's visual art there is at least an element of humour, which gives her some vital distance from herself; her writing, whilst having about it the same vulnerable appeal, lacks the playfulness of her other performances. It may be that first editions of Strangeland will sell for £5,000 in ten years' time. But until then, don't give up the day job, Tracey. To order this book at £11.99, see order form on page 78
LITERARY REVIEW Dec 2005 / Jan 2006 DIARIES&MEMOIRS
T HE Y EAROF M AGICAL T HINKING By Joan Didion (Fourth Estate 227pp £12.99)
W HEN I G ROW U P By Bernice Rubens (Little, Brown 229pp £17.99)
'A LLMYLIFE I have harboured a sneaking assurance that God, or whoever is in charge of these things, would not take me in mid-sentence,' Bernice Rubens wrote, and her confidence was justified. When God, or whoever is in charge of these things, did take a writer in mid-sentence it was not Rubens but John Gregory Dunne. He was sitting in an armchair by the fire with a drink; his wife, the writer Joan Didion, was cooking dinner. 'John was talking and then he wasn't.' Joan saw he was sitting motionless, his left hand raised. At first she thought he was joking. Then she realised he was dead. 'Life changes fast. Life changes in an instant. You sit down to dinner and life as you know it ends,' Didion realised, and the words became her oft-repeated refrain. The new way of life begins with the ambulance, hospital, social worker, telephone calls, friends and eventually funeral, which had to be delayed because their adopted, only daughter Quintana was desperately ill in intensive care. (She died a few months after John.) Those facts alone are enough to evoke pity and terror in the reader, and this book is indeed painful to read, the emotions intensified by the power of the writing. In a direct, unaffected style, Didion describes the ensuing twelve months. She spent them trying to keep hold of John, which does not mean that she authorised unusual attempts at resuscitation nor that she visited mediums, but that thoughts of every detail of their life together remained at the centre of her every moment, waking or asleep. In New York or California, each step was made meaningful by its proximity to where he had walked, each meal by his having consumed a similar one, each moment marked by the thought 'This time last year we...'. Their marriage had been long, and closer than most. They collaborated on screenplays, read, commented on and edited each other's work, and, as both worked at home,
spent their days together. Shattered by his death, Didion followed the well-mapped path from simple grief to mourning, which, she realises, is the act of dealing with grief, and as she travelled, she turned her experiences into a book. It is what widowed writers do – think of Nina Bawden's polemic against the privatised railways, or Sheila Hale's against the NHS, both reviewed in these pages. But therapeutic memoirs do not make cheerful or encouraging reading, and one needs to feel particularly strong to tackle Didion's. Anguish so vividly evoked is infectious. When I Grow Upwill make readers sad too because Bernice Rubens died before it appeared. But it was written cheerfully and in the deceptively random, spontaneous style of all her fiction. According to Beryl Bainbridge's introduction, Bernice never knew from one page to another where the story she was telling would lead, but in this memoir it travels in a straight line from birth to the moment when, aged seventy-five, she settles down to tell the whole, unembellished truth. Bernice's grandparents were Jewish immigrants who settled in Cardiff. Her father was a tallyman, her mother a teacher, and everyone in the family a professional or amateur musician. She was born in Splott, which was, she writes, 'the unmentionable and undisputable armpit of Cardiff'. There are war-child stories of air-raids and rationing and a German-Jewish refugee foster-brother; there was Cardiff High School and University. She studied English – a 'major folly'. Then Bernice became a schoolteacher, a film director, a scriptwriter and an actress. She married, had children, divorced, moved house every few years – and she became a successful novelist. 'My mother said I was over-imaginative, but I was simply a liar by nature. I was happily at home with mendacity. It was less boring than the truth. My natural home lay in fiction.' Writing had not been her ambition. 'My first book just happened.' After that, she used her novels 'to make sense of the past'. She is self-deprecating about the paraphernalia of a successful writer's life. An author tour, whether for publishers or the British Council, is 'whoring' – 'the only other trade in which you sell your goods but you've still got them'. At one literary lunch Bernice is not asked to sign a single book, while Edna O'Brien is besieged by fans. At another, she is introduced as 'Denise Robbins' and makes her speech without correcting the mistake; in New Zealand she is mistaken for her friend Beryl Bainbridge. The two women had met on a writers' tour in Israel and after that 'got into the habit of doing gigs
LITERARY REVIEW Dec 2005 / Jan 2006