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Regulations & Standards |
IVD Technology Magazine
IVDT Article Index
Originally Published March 2000
For IVD companies, access to human tissue samples is essential. Tissue specimens are required for a variety of purposes. They are especially useful during the development of new diagnostic tests and when companies are generating the data needed to support submissions for premarket clearance or approval from FDA.
In seeking to gain possession of such tissue samples, IVD manufacturers have always had to pay attention to relevant legal and regulatory concerns. However, recent events will compel IVD companies to pay even greater attention to such issues relating to sample acquisition. Two forces in particular are driving the need for companies to reexamine their policies on tissue sample acquisition: the dramatic increase in public concern over patient privacy, and the ongoing Human Genome Project and related spin-off areas.
The current crop of legal and regulatory issues affects both prospective studies and retrospective studies. However, the changing environment of public opinion is having the greatest impact on the way that companies conduct studies using banked samples.
Prospective Trials
Prospective clinical trials to support IVD marketing applications have long been subject to FDA's institutional review board (IRB) and informed consent regulations. Such regulation generally requires that an IRB exercise oversight over the study's protocol and subject consent forms, and that subjects who participate in the trials consent in advance to that participation. A standard consent form typically advises the subject that patient privacy will be maintained to the extent permitted by law, subject to inspection by FDA and the sponsor.
In recent years, however, the rapid growth of research in the field of human genetics has focused attention on an important question: What is the scope of a subject's consent? In the past, the consent forms used for most studies referred explicitly to use of the tissues in connection with a specific diagnostic test. With increasing frequency, however, sponsors are seeking to use donated tissues for some additional, unrelated purpose, such as testing for the presence of a particular gene or as part of a pharmacogenomic research project.
FDA regulations do not directly address the propriety of such actions. One could argue that the use of tissue in this fashion is outside the scope of FDA's informed consent regulation, which pertains to research involving human beings rather than specimens. But in any case, the regulation was certainly not drafted with this particular situation in mind.1
This situation is considered in the August 1999 report issued by the National Bioethics Advisory Commission (NBAC), Research Involving Human Biological Materials: Ethical Issues and Policy Guidance.2 Among the wide range of genomic research issues covered by this report is the scope of informed consent forms used in prospective studies.
Although generation of the NBAC report was triggered by concerns related to the Human Genome Project, the logic underlying the report's recommendations is not limited to application in genomic research. NBAC also considered questions that can arise with research using more-conventional methodologies. Thus, the informed consent issues addressed by NBAC—and the commission's recommendations—transcend genomic research.
Like an earlier report by the American Society for Human Genetics, the NBAC report recommends a tiered approach to informed consent.3 The most restrictive level listed by NBAC is the use of tissue solely for the clinical trial described in the consent form. A less restrictive option allows consent for the clinical trial described in the form, but permits further contact with the donor for the purpose of requesting permission to conduct additional research.4
At the other end of the spectrum, the NBAC report recommends that patients be permitted to consent to coded use of their biological materials for any kind of future study. This recommendation was controversial. Of the 23 recommendations adopted by NBAC, this was the only one with dissenting views. One of the dissenters argued that neither IRB review nor informed consent is possible at the time when subjects are asked to provide consent for the future use of stored materials, because those studies "encompass unknown risks and benefits."5 A fall-back position, which was criticized by three NBAC members, is to formulate the consent agreement to cover coded samples "for any study relating to the condition for which the sample was originally collected, with further contact allowed to seek permission for other types of studies." In the end, a majority of the commissioners endorsed the recommendation of a consent agreement that would authorize the use of specimens in future studies.
In accord with the NBAC recommendations, IVD manufacturers that are conducting prospective trials would be well advised to consider the potential future uses of acquired specimens when they begin their study. If the samples are likely to be used in other research projects, the informed consent form should reflect this potential broader application. The consent form must be reviewed by one or more IRBs. If the reviewing board holds to the view that open-ended consent is inherently not informed consent, then the manufacturer may be required to scale back the scope of its consent form, thereby limiting the uses that can be made of the tissue.
With release of the NBAC report, sponsors should now be aware that when tissue samples are obtained for a prospective study, the future use of those samples will depend on the scope of the subject's consent.
Retrospective Studies
According to the NBAC report, repositories in the United States possess a vast library of banked tissues—all together numbering approximately 300 million stored samples. Many such samples are potentially valuable to academic and corporate researchers. Indeed, a flourishing market in the sale of remnant samples has emerged.
Although it may be easier for a manufacturer to obtain banked samples than to acquire new samples for a prospective trial, the legal, regulatory, and ethical issues stemming from the use of banked samples can be far trickier. FDA officials have occasionally suggested that manufacturers should obtain informed consent for all banked specimens used in their research, but implementing such a recommendation is often impracticable, if not impossible.
Historically, the use of banked tissues in retrospective studies has not been considered a significant regulatory issue—particularly if the study sponsor did not know the patient's identity. In recent years, however, the public view of such matters has changed dramatically because of the rapid strides that have been made toward decoding the human genome and the consequent growth of public apprehension over the potential for loss of privacy. And, while genomic research using banked samples is the greatest single cause of such public concern, equivalent fears have also spilled over into other types of tissue research.
In cases where samples were obtained from a subject who consented to research, addressing the legal, regulatory, and ethical issues related to the use of banked specimens can be relatively straightforward. If the study sponsor believes that the original consent agreement is broad enough to encompass its proposed new research, and an IRB agrees, the study can proceed without hindrance. (Testing of tissue for the same disease or condition as before, but with a new analytical tool, would not require a new IRB approval.) The IRB review may be achieved through expedited review without consideration by the full IRB.
In most cases, however, banked specimens are not accompanied by written consent, or the original consent is not broad enough to embrace the new proposed test. In this event, the manufacturer may need to consider whether such tissues may still be used for its study. According to the NBAC report, the key factor for answering this question is the degree to which the samples are truly anonymous.
In cases where samples are completely anonymous, the NBAC report unequivocally affirms that they can be used in a new study. Since no one knows the individuals who provided the anonymous samples, NBAC reasons that there should be no restriction placed on using such specimens in research. Unfortunately, completely anonymous samples are relatively uncommon.
The more typical case is that the laboratory or some other entity has some record that identifies the subject who provided the sample. By removing all identifiers, however, it is possible to make a known sample into an "anonymized" one. Once this step has been performed, neither the laboratory nor the IVD manufacturer can identify the person whose tissue was tested. FDA regulations do not address this practice, which is addressed at length in the NBAC report.
In analyzing this issue, NBAC focused especially on the requirements specified in the Department of Health and Human Services IRB regulation.6 Although this regulation does not govern studies designed to support marketing applications or test development—and is therefore not legally binding on IVD manufacturers who are conducting such research—it nevertheless provides a helpful analytical framework.
NBAC carefully critiqued the IRB regulation and concluded that the practice of using anonymized specimens represented "minimal risk to the subject." For IVD manufacturers, the practical significance of this recommendation is great. When accompanied by IRB consent, it allows companies to use remnant samples from which all identifiers have been irreversibly deleted. The NBAC acknowledges that even anonymized samples may be accompanied by clinical and demographic data about the patient. Such samples may still be used, so long as the data are not so extensive as to permit identification of the subject.
Moreover, because such a study is considered a minimal risk, IRB consent can take the form of clearance by a single authorized IRB member. The member's review should focus primarily on ensuring that anonymity can be maintained; that is, that the test results cannot be linked back to a specific patient.
IVD manufacturers seeking to make use of NBAC recommendations in this area should note that the report's conclusions may be subject to several important conditions. First, the NBAC recommendations are not legally binding; if FDA were to issue a contrary interpretation requiring informed consent in all cases, that interpretation would supersede the NBAC recommendations. Considering the fact that it is almost never possible to obtain such informed consent, however, there is no question that NBAC's interpretation is both preferable to and more practical than the alternatives. As the NBAC report says, its approach allows "important research to proceed while also considering potential harms to the subject."7
Second, IVD firms should be aware that state governments have also begun to regulate genetic testing. A statute adopted by New York, for example, provides that except within the context of a very limited exemption "no person shall perform a genetic test on a biological sample taken from an individual without the prior written consent of such individual."8 IVD companies must ensure that their activities do not run afoul of such emerging state laws.
Finally, the NBAC report does not endorse anonymization as an approach for all studies involving newly collected tissue. Rather, the commission considers this practice a stopgap measure to allow the use of previously collected samples. NBAC believes that, in light of the legal and ethical issues associated with research in this field, prospective consent should be obtained for all future studies.
Securing written informed consent in which the patient authorizes the use of tissue for research will remove many of the legal, regulatory, and ethical uncertainties concerning the use of the samples. However, a physician who is in the midst of treating a patient will not typically be thinking about obtaining consent that would enable a tissue sample to be tested by an IVD company with whom he has no contact. Thus, while prior consent could resolve many issues, obtaining such consent is still not part of the routine in most clinical settings.
Provided that IRB consent is obtained and patient confidentiality truly protected, anonymization of banked samples would still seem to be the best interim solution for meeting the needs of IVD manufacturers while protecting patients.
Manufacturers should not underestimate the potential impact of public concern over privacy and human genomics on their research efforts. As illustrated by the recent public relations debacle related to the use of genetically modified organisms in food, public rejection of a new technology can have devastating consequences.
IVD companies should ensure that they develop procedures that adequately protect donor subjects—even those whose identity they do not know. In the current climate of public opinion, failure to be attentive to the rights of study subjects—including patients and others whose tissue is used in genetic research—could have profoundly negative consequences.
1. 21 Code of Federal Regulations (CFR), sect. 50.20.
2. National Bioethics Advisory Commission (NBAC), Research Involving Human Biological Materials: Ethical Issues and Policy Guidance [NBAC Report], (Rockville, MD: NBAC, 1999).
3. American Society of Human Genetics, "Statement on Informed Consent for Genetic Research," American Journal of Human Genetics 59 (1996): 471–474.
4. NBAC Report, p 65.
5. NBAC Report, p 65.
7. NBAC Report, p 70.
8. New York Consolidated Law Services, Civil Rights Section 79-1(2)(a) (1999).
Jeffrey N. Gibbs is a partner in the law firm of Hyman, Phelps & McNamara (Washington, DC).


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June 5, 2013
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Claudia Louch (BSc Hons MCPP MSc MPharm MNutr) owner of the Natural Dermatology Clinic, creates not only chemical-free skin care, but takes it one step further by customising and personalising your entire skin care regime, internally and externally. Claudia Louch is a scientific natural skin care expert, with a background in pharmacology, allergy, plant based medicine, clinical nutrition and advanced dermatology practice.
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Lady Tiger pitcher Amber Hurd delivers a strike during the Lady Tigers' win over Whitley County Monday.
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They say that using and finding nipples for baby bottles is a trial and error process as far as finding one for your baby goes. But does anyone have any solutions to help the transition? When my daughters were first born, the hospital gave us the similac infant nipple to feed them with, and to make sure we had them, we ordered a whole case online. When the girls started sucking on them so hard that they constantly pinched the neck of the nipple shut, I decided to find alternative nipples to use. I've tried just latex, silicone, and rubber, both slow and medium flow....nuk, standard, and a few other styles...they simply refuse the bottle until the similac nipples are put on and then they eat their formula no problem. So if anyone has any suggestions, let me know. We have no problems ordering the similac infant nipples, I'm just wondering if this has happened to anyone else and how they handled it.
*~*What are little girls made of? Sugar and Spice and everything nice!*~*
I have a program for teen parents and have some Gerber bottles in my donation box. They have the brown nipple that resembles the Similac nipple (if you are using what I think you are). They look very inexpensive, like something that would be sold at a dollar store and not somewhere like Target. Maybe something like that would work.
Babies can be super stubborn. I wanted my daughter to take a bottle, so her daddy could feed her. I bought every bottle in the world and I still have all of them unused. I believe she would have come close to starvation before she took a bottle. :)


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Joe's Dairy - NYC
March 24, 2011 - 5:41pm | by kateOn a recent foray into Manhattan, I went to Joe's Dairy on Sullivan St, famed makers of mozzarella.
The site has been a dairy for many decades. However, in 1977 the original "Joe" sold the store and dairy to seventeen year old Anthony Campenelli, who literally lived next door. It had been Anthony's dream to own the business and he, together with his brother Vincent and other members of the family, still operate it.
Fresh cow's milk mozzarella is made throughout the day in the tiny room behind the store with a certain number of cheeses being set aside for smoking. The smoking process takes place over hickory wood and lasts a mere four minutes.


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There was a guy that had a crush on me when I was in high school, let's call him, "H". I kinda liked him too (at the time). But timing was really bad, and I was trapped with someone else.
I felt bad, because I was convinced "H" and I would have made such a great couple. We got along great, we lived in the same neighbourhood, we liked the same music (at the time) and he was so nice (to me)! He filmed my favourite shows, bought things he thought I would like, and hung out with me lots. But he had a bit of a temper. Today I saw him by coincidence in the subway yelling at someone. I ran as fast as I could, I'm sooo glad that it was not me over there he was yelling at. I'm through with guys who like to make spectacles in public… not my scene!


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It only really matters whether it has 2 slams or 3 available if you use the fast zombie variant... normal zombies can't make full attacks, they are limited to one move or standard action only. I agree with hapless mage that the zombie template is not meant to add slam attacks if the base creature already had one (simply because it wouldn't matter at all given a zombies permanently staggered condition)... I think the wording is more a problem of not accounting for the fast zombie variant when writing up the template. in the end whether you give a fast cave giant zombie three slams on a full attack or four slams on a full attack it would probably not be enough of a change to adjust its CR any further... so just pick one and go with it.
Damocles Guile wrote: Heh - I don't think even paralyzed foes get a penalty to Reflex saves... but if you're shaken or sickened you do. paralyzed creatures are helpless... a helpless character has a dex of 0, so their dexterity modifier is -5. Thus a paralyzed character at best has a much worse chance of making a reflex save then when he is not paralyzed.
I have finished voting, but have decided not to reveal my picks until the final day of voting this year, in an attempt to stave off swaying the voting process... people thinking stuff like "Joseph Kellog seems to have enough votes already that he should make it through with out my help, so I am going to vote for Adman Blanchard instead because even though I hated his archetype I loved his item and would like to see what he can do in the next round"... (note that I just used those names as examples, it is not indicative of what I thought of their archetypes).
here is a list of some items that I really liked that didn't make the top 32 Relativistic Boots (step into the future)
2radly wrote: in fact, it specifically says you can target the creature normally. Yeah, I responded to that it means that you don't have to guess target a 5 foot square and hope the displaced creature is in it (the normal process of targeting a creature with full concealment) instead you can just attack the creature (with the 50% miss chance), also you can target a displaced creature with ranged Target: spells (something that you normally can't do to a creature with full concealment) because target: spells require line of sight. look at it this way, blur prevents sneak attacks, displacement is a more powerful version of blur, ergo it should prevent sneak attacks as well.
Zero_Magi wrote:
I dissagree... the spell says as if it had total concealment. So it should be treated as such accept for the fact that it can be 'targeted normally' (ie you don't have to try to guess what square it is in). If it looks like a duck, quacks like a duck, and does everything as if it were a duck it should work like a duck unless the rules specifically say otherwise (ie. unless rules flat out state 'displacement does not prevent a rogues sneak attack' or some such).
Avatar-1 wrote:
It doesn't it is inferred from the invisibility modifiers in the Attack Roll Modifiers table (Table 8-5) which notes that in addition to +2 to hit with melee or ranged attacks your opponent is denied his or her dex bonus to AC... no place in the rules does it say such for a character attacking from (non total) concealment.
Avatar-1 wrote:
sure as long as the opponent is flat-footed or the rogue is flanking the opponent... concealment doesn't grant you the ability to deny your opponent their dex bonus simply by virtue of having it (as opposed to total concealment such as invisibility which does grant that perk). (note that in the case of obscuring mist, the opponent would have partial concealment from the rogue as well, which would mean that no sneak attack was possible).
Grayfeather wrote: Well it means that the creature is going to stay grappled and take the damage each round for a minimum of 4 rounds if it fails its initial will save... and like all spell combinations it is going to be situational... don't cast it on golems or giants then (although assuming that a rod is not used, the min caster level for a dazing black tentacles means that the tentacles CMB is +20, easily affecting hill giants, flesh, wood, and ice golems, and having a better than 50% chance of working on stone, fire and frost giants and clay golems. If cast on a group of 6 Hill giants (a CR 13 encounter), each tentacle would need to roll above a 3 on d20 to successfully grapple a giant, inflicting 1d6+4 damage and requiring the giant to make a will save (with its whopping +3 to will saves) or be dazed for 4 rounds, each of those rounds it cannot attempt to escape from the grapple, so it automatically takes the 1d6+4 damage and must will save again or reset the daze to 4 rounds from that save...basically any hill giant from the group that is grappled (80% chance) and that fails its initial will save (chance will vary by caster, but likely at at least gonna happen 80% of the time) is very unlikely to ever get free taking the full 15d6+60 (112.5 average over the course of 15 rounds, enough to kill a hill giant)...
How would it work with black tentacles? PRD wrote: So if a foe is grappled and takes the damage he needs to make a will save or become dazed for 4 rounds (seems simple enough), the next round since he is dazed, the foe doesn't get a chance to try to break the grapple, so he automatically takes the damage and has to will save or be dazed (with a failure simply adding more duration to the daze to a maximum of four rounds after the last failed save). This could potentially happen to every creature in the area of effect at the time of casting or that enters it during the spells duration.
Rickmeister wrote:
Are you talking about pellet blast here? The spell specifically states that DR applies to its damage. This is a case of the specific (spell description) overriding the general (DR section).
Based upon the art work (not always the best way to go, but basically all we got given the minimalistic descriptions in the Pathfinder Bestiaries) a barghests hybrid form is more animalistic than a lycanthropes, which are still bipedal in hybrid form I believe, whereas the barhgest is apparently not.
hmmm... must ponder the whirlwind ending question... non-flying creature stuck: it would seem so, the will simply get carried along with the whirlwind unless the elemental chooses to eject them, but remember they can still take actions, including attacking the 'whirlwind' (air elemental) that is holding them.
uhm... if you use acrobatics to move through a threatened square by making an acrobatics check (DC = opponents CMD) you move at half speed (ie threatened squares count as two each, assuming there is nothing else at play that also lowers speed such as difficult Teriann)... if instead you beat his CMD by 10 or more you can move through those squares at your full normal speed (again, assuming there is nothing else at play that also lowers speed such as difficult terrain). Not all uses of acrobatics force you to move at half speed while doing them.
in goblin form yes and no... Armor specifically for hybrid form? I'd probably say yes it would cost double... As for a shield in hybrid form I'd say see Grick's ideas about weapons above. Now I have a different Barghest question.... how come the greater barghest's crushing dispair and charm monster DCs are the same as the normal barghest even though its charisma is 2 points higher?
I'd say not necessarily, since whirlwinds have a limited a duration and end after the time limit runs out... I'd say that if the elemental wanted to end the effect early they could do so as a standard action (similar to dismissing a spell) but if the whirlwind time limit expires it just ends (not an action on the elementals part).
it is not specifically spelled out for you... I figure the designers must have thought that it was obvious from reading the construction sections (and it was more obviously spelled out in the 3.5 Monster Manual, but the wording was changed around a bit in the Pathfinder Bestiary and the obvious bits sort of got lost).
most of the examples use two words... but yes... "kill him/her" while pointing at a specific person should cause the undead to attack that person until he or she is dead, then stand there and wait for other orders... of course if you said "Fight" then the skeleton or zombie would probably just attack who ever was closest to it.
LazarX wrote: continuing to play devil's advocate here.... "standard armor" has nothing to do with it... the eidolon ability says "armor of any kind"... armor of any kind would also include non standard forms of armor would it not?
LazarX wrote: mage armor provides an armor bonus... there for it could be argued that it is indeed armor of a kind... bracers of armor could be considered the same, as could a robe of the archmagi (which provides an armor bonus). barkskin provides an enhancement bonus to a natural armor bonus (ie functions completely differently than mage armor), and thus is not pertinent to the discussion at hand.
given that normal trees and shrubs can't moveof thier own volition, they have strength and dexterity scores of 0. The awaken spell accounts for this by telling you to use the characteristics of animated objects of the correct size... ergo an awakened large sized tree would have the str and dex of a large sized animated object (in this case 22 str and 8 Dex).
PRD wrote:
Feats can't be taken more than once unless they specifically say that they can (and even then it is often with other limitations such as weapon focus must be taken with a different weapon each time, etc.) Shaping Focus has no language indicating that it can be taken more than once... so the best air elemental you will beable to do as a 4 druid/16 barbarian would be medium sized.
:::shrug::: I could see it ruled either way and be fine with it. but if it came up at the table while I was GM, yes he would be dazed if he chose not to make (ie autofail) his saving throw. Technically nearly all saves are optional... you don't have to save against a fireball if you really don't want too for instance... and in such cases I would let the daze automatically take effect.
Burning Disarm: if the creature made its reflex save and dropped the object with out taking damage, they would not be dazed. if the creature was denied a reflex save against the spell (because of a locking gauntlet or such) then they could make a will save to avoid the daze. Burning Magic: I would say no, the extra damage would not trigger dazing spell in this case, as the creature is taking damage indirectly from being on fire, not taking damage directly from the spell again.


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Alchemist / Barbarian / Fighter build, 27 seconds ago by TheTheos
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Ok, so I'm creating a character right now and the GM is using the River Kingdoms, Razmiran, and the surrounding areas as the playing field. The whole thing is probably gonna be a mid to high level game overall, simply because of the mercenary opportunities in the area. I'm creating a rather fun little character background. He's one armed mostly (the second one he lost early on in Numeria, from around half the forearm on down he still has it). Now, I'm gonna create a real standoffish SOB, Chaotic Neutral, Gorum. Pretty standard stuff, human, Kellid, probably a Numerian Trait and a Combat one. Anyway, here's the thing: because he's one armed, he's going to be using a Scizor in his mutilated arm (pretty much permanently strapped on there like a prosthetic). Only being able to wield one different weapon does limit him a bit so I was wondering about something fun like the Jotungrip from Titanmauler Archtype, and how that would stack up with Two Weapon Warrior Fighter Archtype. I'm inexperienced with two weapon user types, usually go with a big two-hander. Being able to wield a Keen Falchion in one hand can definitely make up for the other only able to use a Scizore. Only problem is, early on he's gonna take some penalties in attack rolls. That's less of a concern for me. My question is should I got 2 levels of Titan Mauler and then to Two Weapon Warrior for a build like this? Or is there something more viable? Also, does the Jotungrip stack well with Two Weapon Warrior? If so, what do people recommend by way of feats? I was thinking of going the Deadly Stroke route, but if I do, would I have to make any major sacrifices by way of Two Weapon fighting feats? Or am I going about this all wrong?
Personally, I wouldn't use the Titan Mauler for this character. I don't think that using a slightly larger weapon in your good hand (2H instead of 1H weapon) will ever be worth -2 on attack rolls.
I'd say you could do OK with titan mauler/two-weapon warrior, although you will need a high Dex. You may be better off with multi-classing into ranger instead of fighter: all you need is a 15-16 Dex to qualify for Two-Weapon Fighting and you can use your Combat Style feats to pick up Double Slice (2nd level ranger) and Improved Two Weapon Fighting (6th level ranger) while you concentrate on increasing Str as much as possible.
Still, 2d4 for a falchion isn't much of an upgrade over 1d6 for a scimitar. You might want to look at picking up Exotic Weapon Proficiency (Elven Curve Blade) for 1d10 damage, instead. As an added benefit for multi-classing into ranger, you can cast lead blades: 1d10 becomes 2d8 when lead blades is active.
Hmmm, good points all. However, I don't think I'm going to go with a Elven Blade simply because meh, I hate elves. Blech. Now however, I'm thinking maybe a Falcata might be a better match for the character. Critical rate is not as good, but the multiplier is pretty nasty, and the weapon is very distinctive and probably a bit rarer, simply because it requires a feat to use properly and is more of a national weapon. Also, decided against the deadly stroke route. With a 1 handed weapon character it doesn't seem nearly as worth it.
I would go Ranger 6 / Fighter 4 for the first 10 levels. Ranger to skip those DEX prerequisites and Fighter for the Feats.
If your happy stopping the TWF chain at Improved TWF stop at Ranger 6 and go Fighter the rest of the way for Weapon training. If doing that the Guide archetype is a good route.
I'd actually suggest against using a Ranger feat for Double Slice. With an 18 STR it will add 2 damage to your off hand attacks - I'd defer that until later when you have a magic item to get you the DEX requirement and a really big STR mod to make it pay off. Plus if you take it as a fighter bonus feat you have the option to retrain it if you don't get much mileage from it.
Really, really good point right there. Even when I play a fighter, I usually forget about the retraining of feats. One of the big things right there. Damn there's a lot more involved with TWF than THF (Two weapon fighting vs Two Handed Fighting). I almost prefer the big dumb hulk-smash to this maniac I'm building, but screw it. I gotta go through with it all the way. Now I'm looking at the ranger as a possible choice simply to avoid some of those early high stat requirements. My big question is this: Is Greater Two Weapon Fighting worth staying on until level 10? I would honestly say no, simply because you sacrifice too many feats and levels of fighter (as well as abilities with Two Weapon Warrior) but I'd like to get others opinions on the matter.
With regards to Regular Fighter vs Two Weapon Warrior, are the damage benefits worth giving up Weapon Training? I was always curious about that, simply because it looks like that if you took Dueling Gloves, you wouldn't be able to get the full benefits of them as a fighter because TWW gives up Weapon Training for those special benefits. I might be misinterpreting it though, as it could be reasoned that it is another form of weapon training. And thanks for suggesting ranger, that DEFINITELY helps, simply because I figured going Two Weapon Warrior all the way would be insanely stat consumptive and involve a helluva lot of re-training. With Ranger to 6th, I can get those feats without having to pump dex as my best stat (and I can still focus on Str).
I have to say I like your idea quite a bit. Very unique and memorable character to be sure... I may steal the idea for an NPC in one of my games. It just oozes top level henchman for the BBEG.
I'll have to think of a punny name like one of the old James Bond villains.
Well, I changed my guy's background to him being a Taldan (bit of a standoffish type to say the least). Very aggressive and bloodthirsty as a child, son of nobility of course, killed the wrong person in a duel, and the man's family came after him, took his left hand as a bit of vengeance. He's learned nothing from the lesson they taught him though, and is still violent, aggressive, and intense. He's come to worship Gorum, rather fervently as well. Essentially, after that, he was cast out.
Name Ambros Trumbull Taldan Traits (Heart of the Streets, alternate, replaces skilled) Racial Traits Killer (will come in handy with his Falcata I think) Wealthy Dabbler (Resistance and Dancing Lights) Alignment Chaotic Neutral (at best, but he has tendencies towards both good and evil. He hates being insulted, especially for his mental faculties, and will often fly off at the handle, and while he has few qualms about killing, he doesn't often go out of his way to ruthlessly murder people or hunt them down unless they've really done him wrong)
So far, that's what I got. Gonna start off with 6 levels of ranger, both for the feats and for the spells (probably Lead Blades, Longstrider, Entangle and whatever else I can stuff in there by level 6). After that, heading over to Two Weapon Fighter and really rack up the damage. Only thing about ranger is what to choose as his favored enemy. I would think Human because of how common they are, and the fact that he is a bit of a city boy.
Do you want or have plans for an Animal Companion? If not you can go Guide and instead of FE gain "Ranger's Focus". If you're going to stop at Ranger 6 this is not a bad option. If you were going with more Ranger you'd have to consider losing out on the "Instant Enemy" spell in addition to the Animal Companion - which may not be worth it.
As for other spealls - I actually get some mileage out of Resist Energy.
*Edit - Yes Human is a good choice for Favoured Enemy.
Animal companion never even occurred to me. Heh. Gonna go with the Focus ability to grant favored enemy to his allies.
Ranger doesn't really get you out of the dex prerequisites. It only gets enough bonus feats to get the base TWF stuff and TWF doesn't pay off without two weapon rend or loads of bonus damage (ie. smite, challenge, or sneak attack). What ranger can get you is prereq free Power Attack for a finesse build, but that's only two levels.
Certainly ranger 6 isn't going to do you any good when you hit level 11 and need a 19 dex feat to keep your attacks up.
I'd stick to fighter, rogue, paladin, or cavalier for TWF. I'm pretty sure ranger TWF is a trap.
From d20pfsrd
"The ranger's expertise manifests in the form of bonus feats at 2nd, 6th, 10th, 14th, and 18th level. He can choose feats from his selected combat style, even if he does not have the normal prerequisites."
Now, for two weapon rend, you need the following: Dex 17, Double Slice, Improved Two-Weapon Fighting, Two-Weapon Fighting, base attack bonus +11.
I wouldn't need 19 dex unless I wanted to get Greater Two weapon fighting. I'm not sure it's worth it for an extra attack on an offhand weapon, especially at -10. Scizore isn't light, it's 1-handed martial but not light. That's why after ranger benefits at 6, change to Two weapon warrior and increase damage as well as reduce penalties further.
Dex to 17 is important because it's a requirement for Two Weapon Rend, and outside of Ranger class I still need the requirements for that particular feat.
Using two non-light weapons will give me a penalty, but I'm hoping to counter balance it with the bonuses from TWW.
The reason I recommended Double Slice with the ranger's Combat Style feat is because I made the assumption that the character would already have Two-Weapon Fighting. Also the main reason you want Double Slice is to qualify for Two-Weapon Rend, not for the slight bump in off-hand damage; don't forget that permanent bonuses (such as a belt of incredible Dexterity +2 or a belt of physical might (Str, Dex) +2) count for meeting feat prerequisites (Core Rulebook, pg. 555).
Of course if he went Ranger 10 he could take Two Weapon Rend without taking Double Slice at all.
And yes I was aware that magical items could give stat boosts to meet per-requisites - but thank you for posting the age number!
^still have trouble typing on iPad Ha!
The question was originally for a multi-classed barbarian/(fighter or ranger). Added Str bonuses from Rage (on top of normal Str bonuses) start to stack up when they apply to off-hand attacks with Double Slice; especially when you don't need to keep pumping Dex for Improved Two-Weapon Fighting and Greater Two-Weapon Fighting. Two-Weapon Rend is probably not worth waiting on with a multi-classed barbarian/ranger (or ranger/barbarian); even with only two levels of titan mauler to pick up Jotungrip, taking it at barbarian 2/ranger 9 and taking Greater Two-Weapon Fighting at ranger 10 is probably one of the better choices (unless going for a critical-focused build, for which Two-Weapon Rend is not central).
Personally, I prefer six levels of invulnerable rager, taking Lesser Spirit Totem and Spirit Totem as two out of three rage power choices, for a multi-classed barbarian/ranger (spirit ranger archetype, probably). Toothy half-orc (for bite attacks at any time) with an orc double-axe for being able to use the same weapon for two-handed and two-weapon fighting (and not having to drop a weapon to cast).
A single-classed ranger would be a different build, because there are different considerations.
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One of the reasons the US founding "fathers" inserted the Second Amendment into the US Constitution was that citizen would be able defend themselves from the tyranny! I am sure had these founding Fathers be alive, they would be flabbergasted from the NRA's crazy rhetoric....There is a more civilised and creative way to revolutionise and stop tyranny nowadays. Exchange each superfluous gun and machine gun, with a violin, guitar, flute, drums or other musical instrument. When protesting against the "tyrannic" Government, or any other from of "tyranny" just play music... en masse, orchestrally, or solo... Instrumental and vocal music, has been more effective in revolutionise countries, culture, ideologies, mood, and changes of governments...Than all the guns put together...
Play music? --was this novel idea tried during the French Revolution?
Was it repeated anywhere else?
/Just say no, to drugs.


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text: I visited this trattoria for the first time with a foreign friend. We both loved the food, the service and the atmosphere. The food is not the typical/traditional Tuscan food. Tuscan food can be boring (for someone who lives in Florence). But the Tre soldi not only offer traditional dishes; they also serve non traditional food with special attention to... More


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i dont understand how it hasnt leaked yet..
wow, skat and snug. thats what i like to see.
That argument is redundant. If someone downloads and then doesn't buy, they likely weren't going to buy in the first place. Besides, if it doesn't "leak," it would still be available all over the net as some point.
That argument is redundant. If someone downloads and then doesn't buy, they likely weren't going to buy in the first place. Besides, if it doesn't "leak," it would still be available all over the net as some point.
Again, if they're the type to download the leak and be happy with that... they're not going to buy regardless. It leaks Thursday? They're going to download it on Thursday and not buy it on Tuesday. If it "leaks" the Tuesday of release, they're not going to be all "Well... this shit didn't leak, guess I better go out and buy today." They're just going to continue to wait until it leaks.
Leaks effect nothing. Those who buy, are buying because they want to, those who download and don't buy, are doing so because they're broke and/or wasn't buying in the first place. If anything, downloads are a good promotion tool, it was the foundation of the F.T.I. movement. It allows that person who has never heard of Kaliko the chance to be, "Hm, Genius? Sounds interesting. Lemme download this leak right quick and see," he never would have ran out to the store first day, but he may hear the leak and suddenly decide he's a fan then "run out and support his artists."
Garbage music and a bad economy is what's hurting the music business, not the internet. Besides, like Tech has stated the last several years when asked about his albums leaking, "if you're leaking, it means people are looking for you."
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[Beowulf] ifort and gfortran
Many of your questions may have already been answered in earlier discussions or in the FAQ. The search results page will indicate current discussions as well as past list serves, articles, and papers.
Nifty Tom Mitchell niftyompi at niftyegg.comMon Feb 23 12:27:50 PST 2009
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On Mon, Feb 23, 2009 at 12:39:33PM -0500, Mark Hahn wrote: >> When gfortran is used, then we get >> "segmentation fault" in the middle/during the >> parameter setting stage of the computation. >> I would be grateful if you >> have any idea on how to treat this problem. > > compile with gfortran and add -g. then run inside gdb. > when compiled, are there any warning messages? And. Make sure that the libs you are linking to are compiled with the same compiler (think ABI compatible, not just API). Subtle things like Boolean tests have different underlying representations for True and False. Strings, args(), memcpy and other bits... differ between FORTRAN compilers. I saw some binary compat code bits get checked into Open MPI so search there for this topic and build a check list to simplify debugging with gdb. The logical tests against True/ False can be interesting to debug because compilers may reduce some logical expression to an equivalent test depending on the optimization level. Some source code bugs surface only at different optimization levels so walk through the various levels of optimization. -O0, -O1, ... etc. Even "house libs" can be involved, so look there for mismatches too (GotoBLAS has a lot of permutations for a long list of reasons, some of which are ABI). -- T o m M i t c h e l l Found me a new hat, now what?
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Sharon was a great hostess. She made us homemade biscuits for one breakfast and bread for another. She couldn't have been more accommodating.
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kind of rundown in a kind of rundown city but great location & very friendly
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Very nice hostel! Owner was super friendly...definitely worthwhile staying at!
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We appreciated all the space, with 2 bedrooms and 2 bathrooms for myself, my daughter, granddaughter and her fiancé. Great value for the money.- wish we could have stayed longer in Saint John and seen more of the town, but we were catching the ferry to Nova Scotia the next day. Location of 52 Dorchester was perfect for us. Many thanks to Sharon and Todd for their help and information.
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Alexander Skarsgard
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The AlexSkarsgard.Net Annual Holiday Craft Charity – Share the Spirit With Our Veterans Get out your glitter, your gluegun and paint markers! We have a project for you! In keeping with the Veteran theme of the winter, we've decided to donate hand made ornaments to Veterans! This is what we have in mind: We're […]
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"It was a shock to the nation when we first heard it ... but it has worn off," he said. "We have sobered up -- even though people will still question why."
The allegation was a major fall from grace for a man who made history last year by becoming the first double-amputee runner to compete in the able-bodied Olympic Games in London.
Meanwhile, South Africa's national broadcaster aired a reality TV show featuring Steenkamp discussing her exit from the taped program, on which she was a contestant.
"I'm going home with sort of a sweet taste in my mouth. I don't have any regrets. I don't have any bitterness," she said. "I'm going to miss you all so much and I love you very very much."
The decision to air the program took "much deliberation," and that "this week's episode will be dedicated to Reeva's memory," Executive producer Samantha Moon said.
A fallen hero
When Pistorius was a toddler, his legs were amputated below the knees because of a bone defect.
He runs on special carbon fiber blades, hence the nickname.
A few weeks after the Olympics, he smashed a record to win the men's 400-meter in the 2012 Paralympic Games.
Images of his sports feats flashed across the screens at the time. But by Thursday, it was a jarringly different story.
Pictures of his walk to a police car, his head covered by a sweatshirt, flashed across television screens worldwide.
Then there was his court appearance 24 hours later, grim-faced and sobbing uncontrollably.
Prosecutors planned to upgrade the charge to premeditated murder.
A nation, jolted
Steenkamp's killing rattled South Africa, which is grappling with the aftermath of the recent murder of 17-year-old Anene Booyson -- a case that has put a spotlight on violence against women.
Booyson died after she was gang-raped and mutilated in Bredasdorp, a tiny tourist town southeast of Capetown.
While police have not discussed a possible motive for the 29-year-old model's killing, local media reported that Pistorius had mistaken his girlfriend for an intruder.
But South African authorities stressed that the scenario did not come from them, and said there was no evidence of forced entry at the home.
Police found her in a pool of blood before dawn Thursday after neighbors in the gated community alerted them.
Investigators found a 9mm pistol at the scene.


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Catch and Release Immunoprecipitation Kit From Millipore
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GeneChip® Two-Cycle Target Labeling and Control Reagents From Affymetrix
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Analysis of gene expression profiles by microarray-based methods in samples with limited cells or tissue, such as those from biopsies, flow cytometry, or laser capture microdissection, often requires ...
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Pierce's SeizeX Immunoprecipitation Kit
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The Seize X Immunoprecipitation Kit offers an excellent solution for immunopurifying proteins or complexes without co-elution of the capturing antibody...
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Seize X Mammalian Immunoprecipitation Kit From Pierce
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Grant Bosnich receives SAR award
PERU — Grant Bosnich, the son of Alan and Melissa Bosnich of DePue, has been named the winner of the 2012-13 Sons of the American Revolution Outstanding Citizenship award at St. Bede Academy. The SAR is presented annually to an outstanding senior based on dependability, honesty, courtesy, respect, leadership and patriotism.
Bosnich is a graduate of DePue Junior High School and a member of St. John's Lutheran Church in Peru. He plans to pursue a law degree and is considering Notre Dame, Vanderbilt, Michigan, Augustana and Yale universities.
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Rude Health Muesli No Flamin' Raisins 500g
Product Description
Raisins? Who needs them?
Some of our friends have told us that they don't like raisins or sultanas in their cereal. This muesli is dedicated to them! As well as being a wheat free recipe, it's raisin free too. Out go the dried grapes, in come mangoes, apricots, apples, almonds, Brazil nuts and dates instead. Crunchy and juicy, it's everything you've ever wanted in a muesli - without the stuff you didn't want...
You can make muesli sweet by putting lots of naturally sweet, juicy fruit in it. Or you can sweeten it by putting in a lot of refined sugars. Guess which we do. We choose our ingredients like we choose our friends: we like them wild, not refined.
World record challenge.
Ah, Space Hoppers bring back so many memories of the 70s... that echoing boing sound they made when they bounced... And they're still going strong! Ashrita Furman set the world Space Hopper speed record in 2004, covering 100m in 30.2 seconds. Come on, you can beat that - especially with a good breakfast inside you.
How rude can you get?
If you've been wowed by No Flamin' Raisins, then you'll love our Morning Glory porridge; an out-of-the-ordinary combination of 5 grains and 5 seeds designed to give you the healthiest start to the day... It's totally yummy too.
MORNING. Thanks for waking up with us. We're Rude Health, a small cereal company with big dreams. With a great breakfast inside us, we feel we can do just about anything: change the nation's eating habits, revolutionise farming, and look sexy while line dancing. Sorry if we get carried away. It's the muesli talking.
You're in rude health when...
...the last one to the bus stop is a dingbat. You eat muffins, but don't look like one. You have muscles in places where most people don't even have places. You do something outrageous every day. We wanted to make muesli that keeps you feeling that good all day. This is it.
- No added salt. No refined sugars.
- Blended with Scottish oats.
- Wheat free recipe.
- High in fibre.
- No added sugar.
- Wholegrain.
Product Information
- Speciality / Free From / Wheat Free / Breakfast Cereals
- Food Cupboard / Breakfast Cereals / Muesli & Granola / Muesli
- Speciality / Free From / No Added Sugar / Breakfast Cereals
- Brands: Rude Health
- Dietary & Lifestyle: Vegetarian
Store in a cool, dry place.
Prepare & Use
After we took the raisins out, we realised that we'd made more room for other fruity delights. We love adding fresh berries and even using fruit juice instead of milk.
Because this cereal's made with whole grains and real fruit, you may find the odd piece of husk in your breakfast. Sorry, at least it's organic.
Country of Origin
Country of Packing
1 Glenville Mews,
Kimber Road,
Package Type
Allergen Information
- Contains: Nut, Gluten, Oats
Jumbo Oats, Porridge oats, Barley Flakes, Rye Flakes, Apricots, Mangoes, Pumpkin Seeds, Brazil Nuts, Dates, Almonds, Apple, Cinnamon.
Dietary Information
Suitable for Vegetarians
No Added Salt
Contains Gluten
Contains Nuts
Free From Genetically Modified Ingredients
Nutritional Data
Typical values | per 100g | |||
Energy | 1560kj | |||
Energy | 369kcal | |||
Protein | 11g | |||
Carbohydrate | 65.6g | |||
of which sugars | 3.2g | |||
Fat | 10.8g | |||
of which saturates | 4.2g | |||
of which mono-unsaturates | 5.6g | |||
of which polyunsaturates | 1.1g | |||
Fibre | 9.7g | |||
Sodium | <0.05g |
Customer Reviews
16 October 2013
Love Muesli but Hate Raisins?
Then this is for you. I've picked raisins out of muesli for 20 years and this cereal has revolutionised my mornings - I LOVE it!
11 September 2013
love this more because there aren't any raisins!
It's light and fulfilling. I soak it overnight along with a couple of spoonfuls of low fat yogurt and coconut (UHT) milk. Oats are best eaten when soaked as they release more nutrients.
11 May 2013
1 of 2 found this review helpful.
Not organic anymore
This product used to be organic, but not anymore.
02 August 2012
No flamin anything
So disappointed in this. Being someone who routinely picks the raisins and sultanas out of cereals I thought it was going to be the perfect solution. Turns out to be a very expensive muesli base and did wonder if it is the end of the barrel when they have taken all the good stuff out! Went straight to the chickens. Try the Dorset brown box gloriously nutty instead
29 September 2011
1 of 1 found this review helpful.
a bit boring
This is just basically porridge oats, with a measly handful of dried fruit thrown in. I'm going back to the dorset cereals and will just keep picking the raisins out!
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text:
This is a small hotel, right on the harbour. Cafes and restaurants line the harbourside so dinner with plenty of fresh local fish is only a few steps away. Rooms are spotlessly clean and pleasant. We paid just a little extra for a superior room which gave us more space and extras such as a comfortable sofa and additional toilet.... More
- Official Description (provided by the hotel):
- Small luxury boutique hotel with Italianate rustically and antique furnishing situated in last fisherman's village on west Istrian coast. Villetta Phasiana is equipped with modern technology and offers intimate and discreet atmosphere with all the comforts of fine living. One can enjoy in tranquility in hidden Istrian garden or experience the stillness of Mediterranean life form the terrace looking on the main square, small fisherman port and unforgettable sunset. Only few miles from Pula, Villetta Phasiana is perfectly located in the center of small village Fazana, in front of National park Brijuni islands where one can enjoy stillness of untouched nature and crystal clear sea or where one can play golf. Ex Yugoslavian president Tito knew how to enjoy in the beauty of the islands where he hosted the world famous names as Sophia Loren, Richard Burton and many others. Recently the islands have been visited by many other famous guests like Placido Domingo, John Malkovich, Naomi Campbell and Angelina Jolie. ... more less
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text:
Hi ya,
I found a used board for the right price that I fell in love with. I've only rented or borrowed boards before, so this will be my first owned.
But, its a rounded pintail, and I know that squashtails have the best speed to handling compromise. Do you think I am really going to notice the difference on small waves between a squash and a rounded pintail? I suspect the rounded pintail would be better on bigger waves, but I haven't advanced to those yet. I like the idea of a little smoother turning board as the rounded pintail should provide, but I also might need the speed for small waves.
It's a 9'8" * 23" * 3 1/4 singlefin, and I'm 190lbs. 6'2".
Thanks for any opinions,


text:
Contact our concierge and we'll make a vacation work for you. (888) 297-3299 | Email Concierge
Terra Guest Room Package for 2 Travelers
3 nights(2) Two Terra Guest Rooms Package for 4 Travelers
3 nightsAccommodations for 4:
- Valid for all ages
- (2) Two Terra Guest Rooms
- 1 king bed in each room
- Airbath tub and view of Jackson Hole in each room
Included with this package:
- Taxes
Booking Conditions:
- Price includes hotel taxes only. Any additional taxes, service charges or resort fees will be payable to the hotel directly. Package is subject to promotional rate availability, and additional restrictions or conditions may apply. If you have specific dates in mind, contact us at 1-888-297-3299 to confirm that the hotel has availability for this special package.
(888) 297-3299
Need Assistance? Ask a Travel Concierge.
M-F: 6am - 7pm / S & S: 9am - 4pm Pacific
Contact Hotel Terra Jackson Hole
(888) 297-3299 (US & Canada Toll Free)
(310) 215-8060 (International)
Alert Me
Email me when a new vacation package becomes available for this property.


text:
Joe Ricketts, the very, very wealthy patriarch of the family that owns the Chicago Cubs, is apparently considering dropping $10 million on the creation and mass distribution of a five-minute, cinema-quality attack ad that highlights Barack Obama's relationship with Jeremiah Wright.
The New York Times reported today that the billionaire founder of TD Ameritrade submitted a proposal titled "The Defeat of Barack Hussein Obama: The Ricketts Plan to End His Spending for Good" to the Ending Spending Action Fund Super PAC.
The proposal is a quick, entertaining read. Here it is.
It was the first time anyone truly captured the essence of 2008 Barack Obama: he was the "metrosexual black Abe Lincoln."
The plan goes on and on about the need to finish the job that John McCain wouldn't do and destroy Obama by bringing to light his relationship with Reverend Jeremiah Wright. Oddly, though, the five-minute campaign ad only features two clips of Wright speaking (according to the script provided in the proposal).
They're the clips we've seen before. Both are easily found on YouTube, and were featured on many an evening news broadcast four years ago.
There's the classic "God bless America? No, God damn America!" and the reverend's unforgettable post 9/11 "America's chickens are coming home to roost." Unfortunate for the president, sure, but it's nothing particularly groundbreaking. (Both of the videos are worth a watch, by the way.)
It might be inadvisable for the GOP to dig up Reverend Wright and get into a Super PAC mud-slinging contest that focuses on religion, considering that their own nominee comes from a church that is highly suspect in the minds of many of its own voters (and occasionally allows polygamy and denied priesthood to black men until 1978).
Anyway, the point is that this ad sounds like a spectacular waste of money. Ricketts should use his $10 million to buy something more useful!
Like another year of service from Carlos Marmol and Kerry Wood, for example.


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OverviewIn the wake of Avengers Disassembled, a mysterious new group of teen super heroes appears. But who are they? Where did they come from? And what right do they have to call themselves the Young Avengers? Young Gun Jim Cheung and TV superstar writer Allan Heinberg (The O.C., Sex and the City, Party of Five) promise to shock and surprise! Collects Young Avengers #1-6.


text:
Two men charged in the fatal heroin overdose death of a Marshfield woman have pleaded not guilty.
Justin James Drinka, 22, of Marshfield and Trenton Joseph Blume, 23, of Unity are charged with 1st degree reckless homicide are being held on cash bonds in the Wood County Jail.
Kayla Vanderwyst, 20, was found dead in her home on 808 E. 4th Street in August 20th. Six weeks after an autopsy was performed, investigators were notified that Vanderwyst had died of a heroin overdose.
According to the Marshfield Police Department, as investigators waited for autopsy results, they determined there was probable cause to make the arrests. Once results came in, Drinka and Blume were arrested, accused of providing or supplying the heroin that killed Vanderwyst.
Court records show that Drinka told a detective he knew Vanderwyst died of a heroin overdose and that he provided the drugs. They also show that Blume told police he drove the three to Wausau to pick up the drugs before her death, and that he paid for them.
Both men will return to court in January.


text:
Tributes to father of six who died in Cumbria M6 collision
Last updated at 10:43, Friday, 01 November 2013
TRIBUTES have been made to a 42-year-old man who died in a collision in Cumbria on Monday.
Paul Ross, from Wickham near Newcastle, was travelling home when he tragically died at the scene on the M6 northbound at Lowgill, between junctions 37 and 38.
He was driving a black Ford S Max which left the carriageway and rolled down the embankment.
The two vehicle collision also involved a white Fiat Fiorino van. The van was driven by a 45-year-old man from Ellesmere Port. He was taken to the Royal Lancaster Infirmary with minor injuries.
Mr Ross was a father of six children and leaves behind his mother Maureen, brother James and sister Andrea.
A statement from Paul's family remember him as: "A family man who spent most of his life working away from home. He loved to socialise with his family and friends, and singing was one of his big passions.
"He loved a bit of karaoke and watching Newcastle United. He was a bit of a boyo in his time, but would give you his last penny. He was so kind hearted and generous.
"Paul had a fantastic personality and was the life and soul of the party. He had the most contagious laugh and the warmest smile ever. He was well liked and respected by family, friends and colleagues.
"He is terribly missed by all who knew him and was sadly taken before his time.
"Only God takes the finest and Paul was certainly that."
Emergency services were called to the scene at around 11:09am. Police, fire service, ambulance service and Great North Air Ambulance all attended.
Anyone who may have witnessed this collision or who has any information they believe may be of value to the investigation is asked to call Cumbria Police on 101 and ask for PC 1807 Simon Eyres at Cumbria Constabulary Operational Support Unit, Kendal, or call Crimestoppers anonymously on 0800 555 111.
First published at 12:11, Monday, 28 October 2013
Published by http://www.nwemail.co.uk
Have your say
Paul ross what a top bloke with a heart of gold and a good work mate at Alstom power for over 10 years and will be missed by all his work colleagues all over the country
Paul was my cousin, were all totally devastated, he was a lovely man, R.I.P Paul took far too soon, x


text:
Browsing Faculty of Education by Author "Nitza, A."
Now showing items 1-1 of 1
Nitza, A.; Chilisa, B.; Makwinja-Morara, V. (Routledge. http://www.informaworld.com, June NaN, 2010)[more][less]
Abstract: This article describes a small group intervention for HIV/AIDS prevention among adolescent girls in Botswana. The psychoeducational group model is designed to empower girls to overcome the gender inequality that puts women at increased risk of HIV infection in the country. Group goals include heightening group members' awareness of the influence of the restrictive social messages that surround them and assisting them in developing efficacy and skills to combat the barriers they face. Specific goals, strategies, and interventions for the initial, middle, and termination stages of the group are described. Indigenous and culturally relevant interventions are included in each stage. URI: http://hdl.handle.net/10311/549 Files in this item: 1
Chilisa_JSGW_2010.pdf (548.7Kb)
Now showing items 1-1 of 1


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text:
you cna't get fired for the truth can you??
Originally Posted by Shine Brules senses the suck in you Originally Posted by Dawg I'm not going to start a thread and have it turned into a what Chriza likes to eat.
Rest in Peace my dear Christine, you will be missed.
I used to work on the Fox NFL Sunday show circa 2000. Terry was a cool guy. Howie was a total faggot.
will he be punished by CBS?
Originally Posted by SIPAWITZ will he be punished by CBS? Well, he works for FOX, so I'm guessing no.
Taxed Enough Already Poisoned, never dried. http://www.youtube.com/watch?v=XbGs_qK2PQA
Originally Posted by SIPAWITZ will he be punished by CBS? It's Fox, but that is Terry being Terry. It sounded like an inside joke between him and Johnson
Forum Rules


text:
Although the international coalition and Afghan government are making progress in the war in Afghanistan, "the Taliban-led insurgency and its al Qaeda affiliates still operate with impunity from sanctuaries in Pakistan," according to a new semi-annual report issued by the Pentagon.
"The insurgency's safe haven in Pakistan, as well as the limited capacity of the Afghan government, remain the biggest risks to the process of turning security gains into a durable and sustainable Afghanistan," it said.
While the coalition is on track to turn security fully over to Afghan control, the insurgency "remains a resilient and determined enemy and will likely attempt to regain lost ground and influence this spring and summer through assassinations, intimidation, high-profile attacks and emplacement of improvised explosive devices," the report said.
The report, issued Tuesday, covers security developments in Afghanistan from October through the end of March. It notes this period of time saw several "significant shocks," including release of a video of U.S. Marines urinating on corpses, the inadvertent burning of religious materials by U.S. personnel, several "green on blue" incidents in which coalition forces were killed or wounded by Afghan troops, and the alleged killing of 17 civilians by a lone U.S. soldier.
But the report also says the insurgency has been "severely degraded" by Afghan and NATO combat operations, noting the "most significant security-related development" during the reporting period was the continuing decline in violence.
After five consecutive years in which enemy attacks had increased, they decreased by 9% in 2011 and by 16% in 2012.
While NATO and Afghan forces for months have focused on the Taliban heartland in the south, the share of violence in the eastern sector along the Pakistan border has increased slightly, according to the report. The United States believes this is the major infiltration route for operatives belonging to the Haqqani network in Pakistan that come into Afghanistan to stage high-profile attacks.
The report attributes this improvement to the growth of Afghan security forces and improved training. Afghans partner with coalition forces on 90 percent of coalition operations and lead on about 40 percent of those, the military says.
"Afghan forces are more and more able to take the lead," said a senior Defense Department official at a Pentagon briefing. The official briefed the media on the condition of anonymity.
But there are outside challenges beyond Pakistan. The report noted that Iran is trying to ensure a "dominant, long-term role" in Afghanistan for itself and ensure the permanent withdrawal of foreign forces.
While much of Iran's activity involves openly reaching out with economic and cultural support, the report says there is also "covert support, including the provision of weapons and training for various insurgent and political opposition groups," including the Taliban.


text:
Sometimes I find the English language annoying.
I didn't catch this bug. It caught me.
Believe me, I have caught lots of bugs. I caught them in fields and in trees and in ponds and all sorts of places when I was a little kid.
Bugs and frogs - I caught plenty of both - as well as lizards and toads and all manner of creatures incapable of fighting back. but I digress.
I caught hundreds of bugs while studying entomology in university many, many years ago (long enough now, that I could easily add one more "many" without fearing accusations of exaggeration).
It may seem the same, within the context of the English language and the way we normally use it, but there's a significant difference between catching bugs and getting caught by a bug.
The difference boils down to who feels good about the catching.
Ask a bug collector or entomologist - or even an exterminator - and they'll all agree that, when you (the human, in this catch phrase) catch a bug, it generally feels pretty good.
That's especially true when it's a bug you've been specifically hunting for some time: a special butterfly, a particular sphecoid wasp, one of the rarer carabid beetles. but I am digressing once again.
In any case, it surely doesn't feel bad at all to catch a bug (for us, as the catchers, that is - the bugs probably aren't as happy about being pinned to a piece of cardboard and being euthanized with ether).
Conversely, it never feels good when a bug catches you.
Likewise, I find it annoying when people suggest they have something that is good for a bug that is wreaking havoc with my physiological processes.
I know I tend to be more easily annoying while in the grips of a particularly nasty bug such as the one that has grabbed hold of me this past little while.
But I do not want something that is good for a bug that is running roughshod over my flagging constitution (which is significantly different from a constitutional flag - like the Red Maple Leaf whose adoption by Canada's parliament is celebrated annually, albeit rather quietly this year, on Feb. 15, which was last Friday. but I am digressing yet again).
And neither would you want something that is good for your bug, I'll bet you three bugs and lizard.
When you are being assaulted by a bug, you would be a fool to want something that is good for the bug. You want something that is bad for the bug. You want something that is good for you. Clarity, folks.
It's something that is too often missing from our language.
And it is something that has been missing from my nasal passages for far too long.
Indeed, I'll accept any reasonable suggestions for things that may be bad for the bug that has caught me.
And while I am venting my annoyance over the noisome bug that is tromping all over my personal concept of paradise, I notice that the provincial government has proudly proclaimed that it has amended the Wildlife Act to make hunting "more accessible" to youth.
Hunting and using guns is now easier than ever for kids as early as age 10.
That's what we need, in this day and age of mass murders and the Great American Gun Debate raging south of the border: more kids with more guns.
Hey! Can anybody shoot this bug for me?
@ Copyright 2013


text:
Hello, can somebody please help me to translate the attched text to English? Any help is appreciated. Thanks. "山泉"probably is the title of the picture,meaning the fountains in the mountains.
"中国陕西户县" I guess the place where the painting is done, Shaanxi Hu county "刘志贵作" the author's name is LIU Zhigui. Against this background,"作"simply means "written by / drawn by " "己巳年" represent the year when the painting is done. I searched the internet, probaby 1989. I hope u will find the above useful. Edited 1 time(s). Last edit at 11/21/2011 10:04PM by Blair. thanks Blair, your help is really appreciated. Sorry, only registered users may post in this forum.
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Pros: Its cheap and it is near West Point Academy and downtown Highland falls. Microwave and refrigerator. Cons: The beds were old and thin - very cheap. Your back can tell. Every pillow was lumpy and small. The breakfast is incredibly lackluster - cold coffee, stale bagels, overripe bananas, milk and juice in a refrigerator and I couldn't even get... More
- Also Known As:
- Econo Lodge Highland Falls Hotel Highland Falls
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DHgate Service Pledge - newly updated for 2013!
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Blizzard Entertainment community manager Stephanie Johnson demonstrates the new Diablo III* beta skill and inventory system at the GDC* 2012.
Highlights from Blizzard Entertainment's Diablo III* launch party in Irvine, CA, celebrating the release with contests and laser-etched PC prizes.
Blizzard Entertainment game director Jay Wilson discusses his role and the new Diablo III* networking and gaming features at the GDC* 2012.
Watch the Diablo III* trailer to see how at the end of days, justice will fall upon man and armies clash across the fields of eternity.
Primed for Intel® –K processors, the Intel® Desktop Board DZ77GA-70k Extreme Series maximizes overclocking performance for enhanced experiences.


text:
Some of you who have contact with David may want to send him a note in this time of loss, here near Christmas.
I saw David with his Mother in Atlanta, at the national CBF about five years ago.
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