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Harrison Ford Movies
If Harrison Ford had listened to the advice of studio heads early in his career, he would have remained a carpenter and never gone on to star in some of Hollywood's biggest films and become one of the industry's most bankable stars. Born July 13, 1942, in Chicago and raised in a middle-class suburb, he had an average childhood. An introverted loner, he was popular with girls but picked on by school bullies. Ford quietly endured their everyday tortures until he one day lost his cool and beat the tar out of the gang leader responsible for his being repeatedly thrown off an embankment.
He had no special affinity for films and usually only went to see them on dates because they were inexpensive and dark. Following high school graduation, Ford studied English and Philosophy at Ripon College in Wisconsin. An admittedly lousy student, he began acting while in college and then worked briefly in summer stock. He was expelled from the school three days before graduation because he did not complete his required thesis. In the mid-'60s, Ford and his first wife, Mary Marquardt (his college sweetheart) moved to Hollywood, where he signed as a contract player with Columbia and, later, Universal. After debuting onscreen in a bit as a bellboy in Dead Heat on a Merry-Go-Round (1966), he played secondary roles, typically a cowboy, in several films of the late '60s and in such TV series as Gunsmoke, The Virginian, and Ironside.
Discouraged with both the roles he was getting and his difficulty in providing for his young family, he abandoned acting and taught himself carpentry via books borrowed from the local library. Using his recently purchased run-down Hollywood home for practice, Ford proved himself a talented woodworker, and, after successfully completing his first contract to build an out-building for Sergio Mendez, found himself in demand with other Hollywood residents (it was also during this time that Ford acquired his famous scar, the result of a minor car accident). Meanwhile, Ford's luck as an actor began to change when a casting director friend for whom he was doing some construction helped him get a part in George Lucas' American Graffiti (1973). The film became an unexpected blockbuster and greatly increased Ford's familiarity. Many audience members, particularly women, responded to his turn as the gruffly macho Bob Falfa, the kind of subtly charismatic portrayal that would later become Ford's trademark. However, Ford's career remained stagnant until Lucas cast him as space pilot Han Solo in the megahit Star Wars (1977), after which he became a minor star. He spent the remainder of the 1970s trapped in mostly forgettable films (such as the comedy Western The Frisco Kid with Gene Wilder), although he did manage to land the small role of Colonel G. Lucas in Francis Ford Coppola's Apocalypse Now (1979).
The early '80s elevated Ford to major stardom with the combined impact of The Empire Strikes Back (1980) and his portrayal of action-adventure hero Indiana Jones in Raiders of the Lost Ark (1981), which proved to be an enormous hit. He went on to play "Indy" twice more, in 1984's Indiana Jones and the Temple of Doom and Indiana Jones and the Last Crusade in 1989. Ford moved beyond popular acclaim with his role as a big-city police detective who finds himself masquerading as an Amish farmer to protect a young murder witness in Witness (1984), for which he received a Best Actor Oscar nomination for his work, as well as the praise of critics who had previously ignored his acting ability. Having appeared in several of the biggest money-makers of all time, Ford was able to pick and choose his roles in the '80s and '90s. Following the success of Witness, Ford re-teamed with the film's director, Peter Weir, to make a film adaptation of Paul Theroux's novel The Mosquito Coast. The film met with mixed critical results, and audiences largely stayed away, unused to the idea of their hero playing a markedly flawed and somewhat insane character.
Undeterred, Ford went on to choose projects that brought him further departure from the action films responsible for his reputation. In 1988 he worked with two of the industry's most celebrated directors, Roman Polanski and Mike Nichols. With Polanski he made Frantic, a dark psychological thriller that fared poorly among critics and audiences alike. He had greater success with Nichols, his director in Working Girl, a saucy comedy in which he co-starred with Melanie Griffith and Sigourney Weaver. The film was a hit, and displayed Ford's largely unexploited comic talent. Ford began the 1990s with Alan J. Pakula's courtroom thriller Presumed Innocent, which he followed with another Mike Nichols outing, Regarding Henry (1991). The film was an unmitigated flop with both critics and audiences, but Ford allayed his disappointment the following year when he signed an unprecedented 50-million-dollar contract to play CIA agent Jack Ryan in a series of five movies based upon the novels of Tom Clancy. The first two films of the series, Patriot Games (1992) and Clear and Present Danger (1994), met with an overwhelming success mirrored by that of Ford's turn as Dr. Richard Kimball in The Fugitive (1993). Ford's next effort, Sydney Pollack's 1995 remake of Sabrina, did not meet similar success, and this bad luck continued with The Devil's Own (which reunited him with Pakula), despite Ford's seemingly fault-proof pairing with Brad Pitt. However, his other 1997 effort, Wolfgang Petersen's Air Force One, more than made up for the critical and commercial shortcomings of his previous two films, proving that Ford, even at 55, was still a bona fide, butt-kicking action hero.
Stranded on an island with Anne Hesche for his next feature, the moderately successful romantic adventure Six Days, Seven Nights (1998), Ford subsequently appeared in the less successful romantic drama Random Hearts. Bouncing back a bit with Robert Zemeckis' horror-flavored thriller What Lies Beneath, the tension would remain at a fever pitch as Ford and crew raced to prevent a nuclear catastrophe in the fact based deep sea thriller K-19: The Widowmaker.
As the 2000's unfolded, Ford would prove that he had a strong commitment to being active in film, continuing to work in projects like Hollywood Homicide, Firewall, Extraordinary Measures, Morning Glory, and Cowboys & Aliens. Ford would also reprise one of his most famous roles for the disappointing Indiana Jones and the Kingdom of the Crystal Skull. ~ Rovi
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Brian Helgeland's historical sports drama/biopic 42 relates the historic 1947 baseball season in which Brooklyn Dodgers general manager Branch Rickey (Harrison Ford) decides to sign the first black Major League player, Jackie Robinson (Chadwick Boseman). Although Robinson faces ugly, vicious racism from other clubs, fans, and on occasion his own teammates, Rickey encourages him to not fight back. By following that advice, Robinson allows his remarkable athletic talent to speak for itself, and soon the first-year player becomes one the most popular players on the team, eventually securing the Rookie of the Year award. Christopher Meloni and Hamish Linklater co-star. ~ Perry Seibert, Rovi
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Ender's Game
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A brilliant young strategist rises to the top of his class in Battle School while training to defend Earth against hostile aliens intent on exterminating the entire human race in this sci-fi epic based on the celebrated novel. In the not-too-distant future, our planet has come under attack from a malevolent race of aliens known as the Formics. Incredibly, fearless International Fleet Commander Mazer Rackham (Ben Kingsley) sent them fleeing back into the stars, becoming a living legend in the process. But decorated Colonel Hyrum Graff (Harrison Ford) knows that the Formics will soon return even stronger than they were before, and he's determined to find a new hero who can meet them head on. Enter Ender Wiggin (Asa Butterfield), a modest young man with vast untapped potential. Upon being recruited into Battle School, Ender partakes in a grueling series of simulations, effortlessly mastering every challenge presented to him. Celebrated by his peers and respected by his superiors, Ender is quickly promoted to Command School, where the one and only Mazer Rackham provides him with the knowledge and tools needed to save mankind from certain extinction. As the final battle approaches, Ender prepares to embrace his destiny as one of the greatest heroes in the history of planet Earth. ~ Jason Buchanan, Rovi
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Harrison Ford
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Cowboys & Aliens
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Based on the graphic novel by Scott Mitchell Rosenberg, Cowboys & Aliens is set in 1800s Arizona, where the local cowboys, headed by gunslinger Jake Lonergan (Daniel Craig), and the indigenous Apache tribe have been feuding fiercely for quite a while. Their skirmish is interrupted, however, by the appearance of a spaceship, commanded by an alien creature that's bent on enslaving the human race. It's time for a six-gun shoot-out between these cattle rustlers and space invaders, and there might even be a temporary peace between the cowboys and Indians as they both take aim at these extraterrestrial uninvited guests. Jon Favreau directs from a script by Star Trek scribes Alex Kurtzman and Roberto Orci, with help from Lost's Damon Lindelof. Olivia Wilde, Harrison Ford, and Sam Rockwell fill out the headlining cast. ~ Cammila Collar, Rovi
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Morning Glory
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Produced by J.J. Abrams and written by Aline Brosh McKenna (The Devil Wears Prada), director Roger Michell's comedic glimpse into the cutthroat world of live television finds a desperate female news producer (Rachel McAdams) attempting to put out the flames between an anchorman (Harrison Ford) and his blustery but iconic cohost (Diane Keaton) in a last-ditch effort to save their failing morning show. Jeff Goldblum co-stars in the Paramount Pictures production. ~ Jason Buchanan, Rovi
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Extraordinary Measures
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Inspired by an incredible true story, the CBS Films docudrama portrays one father's desperate quest to save his children from succumbing to a rare life-threatening genetic disorder. Working-class father John Crowley (Brendan Fraser) is finally on the fast track to corporate success when his two young children, Megan and Patrick, are diagnosed with Pompe disease -- a condition that prevents the body from breaking down sugar. In time, it disables the heart and the muscles, ultimately resulting in death. With the support of his wife, Aileen (Keri Russell), John ditches his career and teams with unconventional specialist Dr. Robert Stonehill (Harrison Ford) to found a bio-tech company and develop a cure in time to save the lives of Megan and Patrick. As Dr. Stonehill works tirelessly to prove the theories that made him the black sheep of the medical community, a powerful bond is forged between the two unlikely allies. Still, their greatest struggle is yet to come. ~ Jason Buchanan, Rovi
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Brendan Fraser
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Crossing Over
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Harrison Ford, Ray Liotta, and Ashley Judd star in Running Scared writer/director Wayne Kramer's harrowing look at life amongst illegal immigrants and the immigration enforcement agents whose job it is to ensure that the U.S. borders remain secure. Every day, a new batch of immigrants comes flooding into Los Angeles in search of the American dream -- and every day the price of that dream rises exponentially. As the desperation of these newcomers continually tests the humanity of Los Angeles immigration enforcement officers, the face of a 21st century L.A. gradually begins to take form. ~ Jason Buchanan, Rovi
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Ashley Judd
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NOVA: Naturalist E.O. Wilson - Lord of the Ants
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As produced by WGBH - Boston's PBS affiliate - this documentary program provides a biographical portrait of Earth-shaking entomologist and zoologist E.O. Wilson. In 1975, Wilson published a now classic tome entitled Sociobiology: The New Synthesis, which posited the idea that evolutionary concepts could be used to account for social behavior in the animal kingdom (including the behavior of
homo sapiens
). Upon its initial appearance, the book generated tremendous controversy and dissent, but in time the scientific community linked genes to human behavior; their findings virtually guaranteed Wilson a reputation as the father of sociobiology. The program discusses Wilson's early life, his research, the implications of his findings and his subsequent move into conservation efforts. Harrison Ford narrates. ~ Nathan Southern, Rovi
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Indiana Jones and the Kingdom of the Crystal Skull
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Everyone's favorite archeologist adventurer dusts off his hat and trusty whip for yet another globetrotting trek as Indiana Jones returns to the big screen nearly 20 years after racing for the Holy Grail alongside his father in Indiana Jones and the Last Crusade (1989). Harrison Ford reprises his role as the iconic, snake-loathing screen hero in a sequel that also finds Karen Allen returning to the series for the first time since 1981's Raiders of the Lost Ark. Ray Winstone, John Hurt, Jim Broadbent, and Shia LaBeouf round out a cast that also features Cate Blanchett in the role of villainous Russian operative Agent Irina Spalko. Steven Spielberg calls the shots on a script penned by David Koepp (and adapted from the screen story by executive producer George Lucas). ~ Jason Buchanan, Rovi
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Cate Blanchett
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Dalai Lama Renaissance
As the curtain rapidly fell on the 20th Century, his holiness Tenzin Gyatso, the 14th Dalai Lama of Tibet, grew so deeply troubled by the state of the modern world that he invited 40 pivotal Western thinkers to his secluded home in Northern India's Himalayan Mountains, for a lengthy and pointed brainstorming session on the problems of contemporary society and how to solve them most effectively. Foreseeing the importance of this event, documentarist Khashyar Darvich joined the group with an 18-member, 5-camera crew in tow (sponsored by the Wakan Foundation for the Arts) and sought to capture the event on film. This yielded some 140 hours of video footage, edited down to feature length for Darvich's documentary Dalai Lama Renaissance. The film preserves, in 80 minutes, the most insightful, illuminative and engaging dialogues from Gyatso's conference. Oscar-nominated actor Harrison Ford (Frantic) narrates. ~ Nathan Southern, Rovi
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A businessman becomes the last line of defense for his family and his business in this thriller. Jack Stanfield (Harrison Ford) is an upper-echelon technology executive at Landrock Pacific Bank, a leading financial institution based in Seattle. Stanfield oversees security for Landrock, and has made sure that their online banking services are the best-protected in the world, and that the bank's data is safe from hackers and other intruders. However, Stanfield finds out the hard way that his system does indeed have a flaw when he's visited by Bill Cox (Paul Bettany), a cold and calculating man who has spent months learning everything there is know about Stanfield and his family. Cox's underlings have taken Stanfield's wife, Beth (Virginia Madsen), and their two children hostage, and they inform Jack that they will be released only when he uses his knowledge of the bank's security systems to deposit 100 million dollars in Cox's account in an offshore bank. Stanfield is deeply wary but willing to go along to ensure the safety of his family, but when he has reason to doubt that Cox and his cohorts will live up to their end of the bargain, he swings into action to exact justice against the criminals. Firewall also stars Alan Arkin, Robert Forster, and Mary Lynn Rajskub. ~ Mark Deming, Rovi
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Paul Bettany
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The Search for Life: Are We Alone?
Scribes Ann Druyan and Steven Soter, best known for co-scripting the epic television miniseries Cosmos with Carl Sagan, reteam for this short documentary - a production of the Hayden Planetarium at the American Museum of Natural History in New York that was created exclusively for planetarium viewing. As narrated by Harrison Ford, the program speculates on the existence of extraterrestrial life, given the recent discovery that seemingly countless numbers of planets exist outside of the Earth, produced by the same processes that are still creating planets and stars throughout the Milky Way. The program employs a series of 3D visuals drawn from recent scientific discoveries and images culled from NASA missions, thus "transporting" viewers to new and unfamiliar locales including the surface of Mars, the exterior of Jupiter's moon Europa, the interior of a cloud of interstellar gas (during the birth of the solar system) and much more. Stephen Endelman composed the score. ~ Nathan Southern, Rovi
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Hollywood Homicide
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Further cementing 2003 as the year of Ron Shelton cop movies, the director continued his vacation from the sports genre with Hollywood Homicide, a police comedy that comes right on the heels of Shelton's Dark Blue, a decidedly grittier cop thriller. The film stars Harrison Ford and Josh Hartnett as LAPD homicide detectives Joe Gavilan and K.C. Calden, two cops with bigger dreams. Gavilan moonlights as a real estate agent, while Calden teaches yoga and yearns for a career on the big screen. When an entire hip-hop group is murdered on-stage, Gavilan and Calden are called in to handle the case. As their investigation progresses, they begin to suspect that the rappers were offed for attempting to get out of their recording contract with label head Sartain (Isaiah Washington). Along with Bruce Greenwood and Keith David, the supporting cast boasts a plethora of real-life musicians, including Dr. Dre, Gladys Knight, Dwight Yoakam, Master P, and Ronald DeVoe of New Edition and Bell Biv DeVoe. ~ Matthew Tobey, Rovi
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Josh Hartnett
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K-19: The Widowmaker
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A real-life historical incident becomes the basis for this military thriller from director Kathryn Bigelow that's reminiscent of such submarine dramas as Das Boot (1981), The Hunt for Red October (1990), Crimson Tide (1995), and U-571 (2000). Harrison Ford stars as Captain Alexi Vostrikov, a Russian naval officer who's being given command of the Soviet Union's first nuclear submarine, K-19, at the height of the Cold War in 1961. The vessel's previous commander, Captain Mikhail Polenin (Liam Neeson) has been demoted to executive officer following a botched test and his outspoken assertions that the flagship is not yet ready for deployment, but he curbs his resentment and resolves to serve his new superior well. Polenin's concerns are well founded: parts are not yet installed, equipment is missing, and the ship's doctor is killed in an auto mishap. Political pressure forces Vostrikov to sail his crew into the North Atlantic anyway, for a missile fire test that serves as a warning to the U.S. that its enemy is now its technological equal. The test is a success, but a disastrous leak in the K-19's reactor cooling system soon threatens to create enough heat to detonate the craft's nuclear payload -- which would certainly be mistaken for the first salvo in a worldwide atomic exchange and spark the beginning of World War III. With no other option, Vostrikov orders his men to repair the damage in ten-minute shifts, irradiating them hopelessly. The conflict between the seemingly bureaucratic Communist Vostrikov and the more humane Polenin escalates, until a surprising twist reveals where both officers' loyalties truly lie. ~ Karl Williams, Rovi
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Liam Neeson
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Lost Worlds: Life in the Balance
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Narrated by Harrison Ford, this documentary explores a number of diverse corners of our earth, from the microscopic world that exists under a major american city to the bottom of the ocean to the remnants of the ancient Mayan society. Originally released as an IMAX film, Lost Worlds: Life In The Balance was directed by Bayley Silleck. ~ Matthew Tobey, Rovi
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Apocalypse Now Redux
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Francis Coppola had more than his share of production difficulties while shooting his epic-scale Vietnam War drama Apocalypse Now, including disastrous weather conditions, problems with his leading men (Harvey Keitel was fired after less than two weeks on the project and was replaced by Martin Sheen, who suffered a heart attack midway through production), and a schedule and budget that quickly spiraled out of control (originally budgeted at $10 million, the film's final cost was over $30 million). But Coppola's troubles didn't end when he got his footage into the editing room, and he tinkered with a number of different structures and endings before settling on the film's 153-minute final cut in time for its initial theatrical release in 1979. Twenty-two years later, Francis Coppola returned to the material, and created Apocalypse Now Redux, an expanded and re-edited version of the film that adds 53 minutes of footage excised from the film's original release. In addition to adding a number of smaller moments that even out the film's rhythms, Apocalypse Now Redux restores two much-discussed sequences that Coppola chose not to include in his original edition of the film -- an encounter in the jungle between Willard (Martin Sheen), his crewmates Chief (Albert Hall), Clean (Larry Fishburne), Chef (Frederic Forrest), and Lance (Sam Bottoms) and a trio of stranded Playboy models on a U.S.O. tour, as well as a stopover at a plantation operated by French colonists De Marais (Christian Marquand) and Roxanne (Aurore Clement). Apocalypse Now Redux received a limited theatrical release in August of 2001 after a well-received screening at the Cannes Film Festival -- the same month that the film finally reached theaters in 1979, after a rough cut received a Golden Palm award at the Cannes Festival. ~ Mark Deming, Rovi
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The Concert For New York City
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In the wake of the attacks on New York City and Washington D.C. on September 11, 2001, many figures in the entertainment community stepped forward to offer their talents to raise money towards relief efforts for the victims and their survivors. On October 20, 2001, some of the biggest names in popular music appeared at New York's Madison Square Garden in a special marathon concert to raise funds, and to pay tribute to the firefighters and police officers who gave their strength, their courage, and in some cases their lives to help the victims of this tragedy. The Concert for New York is a video that documents this historic evening. Musicians include Paul McCartney, Mick Jagger, Keith Richards, Bono, and many more. The long list of celebrity presenters includes Rudy Giuliani, Bill Clinton, Hillary Clinton, and Halle Berry. And several filmmakers contribute short films on New York, including Woody Allen and Kevin Smith. ~ Mark Deming, Rovi
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What Lies Beneath
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In this supernatural thriller, a woman believes that a visitor from another dimension is trying to guide her into a sinister mystery. Feeling lonely after her daughter leaves home for college, Claire (Michelle Pfeiffer) begins to sense that something is wrong in her house, and feels a spirit is trying to contact her. At first her husband Norman (Harrison Ford), a scientist doing research in genetics, attributes her paranormal beliefs to stress or possibly a nervous breakdown, and sends her to a psychiatrist (Joe Morton) who puts no more stock in Claire's stories than does Norman. While Claire's contention that someone or something sinister is afoot leads her down a number of blind alleys, in time she becomes convinced that the mysterious happenings at her home are somehow connected to the disappearance of a woman who was a student at the nearby college -- and bore a striking resemblance to Claire. What Lies Beneath marked the debut of screenwriter Clark Gregg, whose script is based on a story by himself and Sarah Kernochan; the supporting cast includes Diana Scarwid as Claire's best friend Jody, and James Remar and Miranda Otto as a contentious couple living next door. ~ Mark Deming, Rovi
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Michelle Pfeiffer
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Unauthorized Star Wars Story
The Unauthorized Star Wars Story is an entertaining and informative behind-the-scenes account of the making of one of moviedom's enduring classics. The documentary brims with fun and gossip that both devoted Star Wars fans and casual viewers will find amusing. Interview clips include conversations with Charles Lippincott, former vice president of Lucasfilm, George Lucas and Rick McCallum, producer of The Phantom Menace. The film's stars are also interviewed, including, Harrison Ford, Carrie Fisher, Mark Hamill, Anthony Daniels who played C3PO, Peter Mayhew who played Chewbacca and Kenny Baker, otherwise known as R2D2. From pranks on the set to the cult world surrounding Star Wars, this film tells all. ~ Sally Barber, Rovi
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Tony Bennett: Live By Request
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This video captures Tony Bennett performing before an adoring audience during a 1998 concert that was recorded for A&E as part of their Live By Request series. Featuring appearances by such luminaries as Elvis Costello, Billy Joel, and Sting, the concert fins Bennett performing timeless favorites like "Fly Me to the Moon", "Steppin' Out With My Baby", "Chicago", and "They Can't Take That Away From Me". ~ Perry Seibert, Rovi
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Jane Goodall: Reason for Hope
In this inspiring documentary, a companion to Jane Goodall's memoir of the same name, the famed scientist and tireless environmental activist explores the connections between her work and her deep personal faith. From a restless childhood in England to the wilds of Africa and beyond, Goodall's life has taken a fascinating series of twists and turns, and here she draws upon that vast experience, calling people to defend and preserve the natural world in the name of God and humanity. Harrison Ford narrates, while Bobby McFerrin and Yo-Yo Ma provide a rich, African-themed soundtrack. ~ Sarah Welsh, Rovi
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Random Hearts
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Two people who've known the pain of loss and the sting of betrayal are brought together under trying circumstances in this romantic drama. Dutch van den Broeck (Harrison Ford) is a police detective based in Washington D.C. whose wife works for an upscale department store; flying to Miami on business, she dies shortly after takeoff in one of the worst aviation disasters in the city's history. However, Dutch finds out that his wife wasn't actually traveling on business: Kay Chandler (Kristin Scott Thomas) is a prominent political figure whose husband was also killed in the crash, and Dutch and Kay discover that their spouses were on the plane together because they were having an affair. Random Hearts was directed by Sydney Pollack, who also worked with Harrison Ford on his previous film, Sabrina. ~ Mark Deming, Rovi
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Six Days, Seven Nights
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Ivan Reitman directed this romantic comedy-adventure that opens in New York where fast-paced magazine associate editor Robin Monroe (Anne Heche) and her boyfriend, Frank (David Schwimmer), leave for a week's vacation on a remote island. They've already been together for three years, so when Frank asks her to marry him, she says yes. For a one-day Tahiti photo shoot, Robin engages the services of South Pacific cargo pilot Quinn Harris (Harrison Ford). Robin and Quinn head off to do the shoot, but a squall forces Quinn to land his DeHavilland Beaver on the beach of a remote, unknown island. With broken landing gear, they're trapped there. Search parties set forth. Robin and Quinn cope with each other. Survival skills surface. Sexual tensions escalate. Meanwhile, back at the hotel, Frank and Quinn's girlfriend, Angelica (Jacqueline Obradors), compare concerns at the hotel bar. Several days later, the search is called off. Quinn and Robin are left to their own devices, including removing pontoons from a convenient Japanese war plane and attempting a take off. Filmed on the Hawaiian island of Kauai. ~ Bhob Stewart, Rovi
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Anne Heche
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Mustang: The Hidden Kingdom
Narrated by Harrison Ford, Mustang: The Hidden Kingdom is a 90-minute documentary that features the kingdom of Mustang, a feudal Tibetan community in the remote Himalayas. You'll travel there with the Dalai Lama's personal envoy for an in-depth look at an isolated Buddhist culture where polygamy and polyandry are standard practices, lamps ward off evil spirits, and a king's word is law. Highlights of the film include rare footage of age-old ceremonies seldom before seen by the outside world. ~ Kathleen Wildasin, Rovi
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The Devil's Own
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A policeman plays Good Samaritan to a visitor from Ireland, only to discover that he has a potentially deadly secret. Belfast-born Frankie McGuire (Brad Pitt) saw his father gunned down by enemy soldiers at the age of eight, and when he grew up he joined the Irish Republican Army, determined that one day his father's death would be avenged. An especially ruthless "volunteer," Frankie is responsible for the death of 13 British soldiers and 11 policemen. After a particularly bloody battle, Frankie sails to the United States in a ragged tugboat he has restored; with a huge bundle of cash, Frankie intends to buy a stock of Stinger missiles from an underground arms dealer in America, Billy Burke (Treat Williams). Upon arrival in New York, Frankie is met by a judge who is sympathetic to the IRA's cause and who arranges a place for him to stay. Using the name Rory Devaney, Frankie moves into the home of Tom O'Meara (Harrison Ford), a scrupulously honest cop. Tom is already in the midst of a personal crisis; his friend and partner Edwin Diaz (Ruben Blades) recently shot a man that he knew was unarmed in the line of duty, and while Edwin wants Tom to help him cover up the matter, Tom's conscience will not allow it. When Tom begins to realize that "Rory" is not simply a man running from the violence of his homeland, he's torn between his sympathy for Frankie's tragic childhood and his desire to see justice served and prevent needless death in Ireland. ~ Mark Deming, Rovi
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Has the Federal Reserve Overstepped its Mandate? >
For Better or Worse, Fed Is Just Doing Its Job
Question monetary policy if you like, but Fed's actions have been consistent with its mandate
October 21, 2011
The Federal Reserve's actions over the past four years have been fully consistent with its mandate to guard against inflation and promote the prosperity of the U.S. economy and the stability of our financial system.
The Federal Reserve System was established by an act of Congress in 1913 after years of deliberation following the Panic of 1907. The new central bank was seen as needed to provide the nation with a safer, more flexible, and more stable monetary and financial system. Subsequent legislation during the Great Depression transformed its structure and expanded its authorities, and later there was legislation that further modified and expanded its activities. However, the core mandate of the Federal Reserve has remained essentially the same for almost a century. It rests on four pillars:
- Conduct of U.S. monetary policy in pursuit of maximum employment, stable prices, and moderate long-term interest rates.
- Supervision and regulation of U.S. banks to ensure their safety and soundness.
- Maintenance of the stability of the financial system and limiting systemic risks in financial markets.
- Provision of services to the financial system including the U.S. payments system.
The actions of the Board of Governors of the Federal Reserve System and the Federal Open Market Committee since the summer of 2007 have been derived from this four-part mandate and the powers granted by the Congress to carry it out.
[Browse a slide show of 5 bright spots in the U.S. economy.]
Most of the Federal Reserve's actions--such as the large-scale asset purchase program known as quantitative easing two (QE2)--were conventional in nature even if they were unusual in how they achieved their effects. A few measures adopted by the Federal Reserve were unconventional and involved the exercise of seldom-used powers.
One can disagree with the content of some Federal Reserve decisions or question their effectiveness without doubting whether they fell under the Federal Reserve's mandate. Each decision, along with its underlying legal authority, was debated within the Federal Reserve. In the end, each was adopted either unanimously or by a substantial majority by the relevant Federal Reserve decision-making body. However, no one should doubt the dedication and sincerity of Federal Reserve decision makers in acting in a manner consistent with their understanding of the Federal Reserve's mandate and their obligations under the Federal Reserve Act.
- Read about: what more the Fed might do to spur recovery.
- View: a slide show of 6 ways to fix the housing market.
- See: a collection of political cartoons on the economy.

subset: commoncrawl


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ArcheAge Overview
All players begin their journey on either the Nuia or Harihara continents. From there they explore the world, cooperating or competing with each other. Remnants of the Lost Continent, where the ancestors of the world's races lived together in peace two thousand years ago, still dominate the landscape. If you explore deep into the hearts of these ancient relics, you may discover the secrets of legendary gods and heroes. Or you may reveal more details about the catastrophe that caused the Nuia and Harihara schism. It all depends on your choices
Key Features
Combining Abilities On Your Own Free Will
In ArcheAge, by combining 3 abilities out of 10, you can create your own class.
10 Abilities in ArcheAge presents 10 Gods and Heros in ArcheAge World. Each abilities have its own unique feature and skill.
By free ability combination, you cannot only make the basic MMORPG classes such as Warrior, Wizard, Healer, but also unique classes by combining abilities on your own free will.
Also, the 3 abilities that you picked at first are changeable. You can change the ability combination by paying certain amount of gold.
ArcheAge Screenshots
ArcheAge Featured Video
ArcheAge Review
Coming Soon…
ArcheAge Videos
Official Trailer
ArcheAge System Requirements
Coming Soon. . .
ArcheAge Articles
- Shotgun News 11/22: ArcheAge, LoL, League of Angels, and more! - Posted on November 22, 2013
A daily shot of MMO news featuring the best and biggest news in the industry.


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The Ceramic Lamp is equal parts sculpture and lighting. Its glossy, curiously curvaceous figure is balanced by an elegant cotton shade with a gold-toned metallic trim, and topped with an orb-like finial that pulls together the whole illuminating ensemble.
Set of 2 lamps. Shade height: 10". Shade bottom length: 16". Shade bottom width: 16". 3-way switch. Uses one 3-way 100-watt bulb.


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text:
Like many of our family projects, this one came from seeing an item in a store and saying, "heck, we could make one of those, and probably better...or at least bigger." We were in the Christmas aisle admiring the gingerbread houses when we realized that 3 out of 4 members of our family don't even like…
ContinueAdded by Randy Slavey on December 10, 2012 at 6:30pm — No Comments
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Denise and Tim were taking the 4:30 am convoy to Abu Simbel, so we'd said our farewells the night before; nice travelling companions. We had opted for the 11:00 am convoy so made our way rather more leisurely. We went in a Kia SUV, driver but no guide. At the rendezvous point a soldier ran a mirror on wheels under the car (to check for explosives?) and the car's license plate was recorded, although we weren't asked for our passports. There were 6 vehicles in the convoy (all foreigners need to drive in the convoy, unless they fly to Abu Simbel). Several police/army checks, or slow-downs before we left Aswan, then some road works then open road. There was a surprising amount of "local" traffic. It's 280 km to Abu Simbel and it took under 3 hours.
We were dropped off at our hotel first: a small venture by the Nubian singer-owner to encourage local culture and enterprise. His house has 5 guest rooms, all built in the local style (dome roofs and arched passageways, roof terrace). His land goes from the road to the edge of Lake Nasser and they grow their own produce. We rested and had lunch (Nile perch and chicken plus various side dishes). Our driver was waiting for us at 3:30 to take in the Temples when it was a bit cooler. 15 minute drive to the ticket office, then another 20 minute walk around the complex hill (all created on top of the original location) and there they were: the massive 4 statues of Ramses II and his temple to Ra (Sun Temple), with the smaller temple he built to his "beloved wife" Nefatari and the goddess Hathor. Ramses's temple is remarkable in its state of preservation and all the side chambers which we hadn't seen before, but, Egyptologists that we are, we all agreed that the actual carvings were a lot cruder than others we'd seen! The scenes are dominated by Ramses smiting his foes!
Next door the scenes are gentler but no less moving. Strictly speaking there is no photography inside but photos were taken; baksheesh was exchanged!
The booth selling Sound and Light tickets opened at 6 pm and the show was at 7 pm, so there wasn't time to go back to the hotel. We enjoyed the visitors' centre information about saving and moving the temples and then went back to the temples. Due to the large number of French tourists (in a boat up from Aswan, which must be a lovely way to go) we had a headset for the English version, which was read by English actors and was perfect, if over-the-top!). In 35 minutes it told the story both of saving the temples and their building by Ramses – lots of dramatic music and lights – a good show! We were told it was the best of all the ones that are offered at every destination. Anna's headset didn't work immediately and in compensation she was given a disk of what we were told were pictures of the temple, but sadly just turned out to be a promo disk of all the Sound and Light shows!
Back to the hotel for a lovely tagine dinner…and so to bed.
Check out these great guidebooks for Egypt!


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Choose your spray pattern and soak your competition 4 different ways with the SWITCH SHOT water blaster! Want to send 3 streams of water at them from up to 25 feet away? Launch an atomized mist attack? Or just massively soak them? Just twist the knob on this versatile blaster to choose Scattershot, ......More
The NERF N-STRIKE ELITE RETALIATOR blaster is four blasters in one. Modify your blaster for any mission by changing its configuration in moments. Three interchangeable components give you the correct options for any situation, and the components work with many other N-STRIKE ELITE blasters (each ......More
Pump-action power and a removable 10-disc clip let you go the distance with the VORTEX PRAXIS blaster! Whether you need maximum mobility or enhanced fire control, you can modify your blaster with the removable shoulder stock and add accessories with the Tactical Rail System. You can even create one ......More
Put some serious blasting power in your pocket with the TRIAD EX-3 blaster! Don't let this 3-dart blaster's micro size fool you – it's small but mighty, with the same long-range power as other N-STRIKE Elite blasters (sold separately). Its smart technology tells it which barrel is loaded so you can ......More
Load up big-time for any N-STRIKE Elite mission with the Tactical Vest Kit! The kit's Tactical Vest, included ammo and Quick Reload Clips let you stay heavily armed even while you're on the move. The vest's dart storage loops hold up to 12 darts, and you can fit 2 Quick Reload Clips in the clip ......More
Take aim at COBRA villains just like your G.I. JOE heroes with the NINJA COMMANDO BLASTER toy! This powerful blaster holds 10 darts fully loaded and the barrel auto-rotates when you pull the trigger for major rapid-firing action! Take evasive action and then use the targeting sight to take your ......More
Take your DART TAG game to the next level! This motorized blaster lets you dominate the game with a 20-dart rapid-blast attack! The rotating barrel lets you deliver high-scoring rapid fire, and the removable stock lets you take your blasting action on the go. When your opponent is in sight, grab ......More
VORTEX disc blasters are the cutting edge in long-range, high-powered technology, with revolutionary XLR Disc Tech that hurls ultra-distance discs for the ultimate battle experience. Fire up your missions with the "electrifying" excitement of the LUMITRON blaster — its FIREFLY TECH clip energizes ......More
Take your DART TAG game to the next level! This motorized blaster lets you dominate the game with a 20-dart attack! The rotating barrel lets you deliver rapid blasting action and the removable stock lets you take your blasting action on the go. When your opponent is in sight, grab your blaster and ......More
The most skilled warriors rely on speed and strategy, rather than brute force. The Stonewall Shield and Sword make it possible to protect yourself from the most powerful attacks even as you strike the weakest point in your enemy's defense! Arm yourself for the ultimate battle experience and grab ......More
Get your team together and prepare to play at your best with this awesome WEATHER BLITZ flag football set. With 8 belt-free, easy-clip orange flags and 8 belt-free, easy-clip red flags, you're set to start a serious series of 4-on-4 action in seconds! And with this football's special WEATHER BLITZ ......More
"Round" out your N-STRIKE arsenal with this awesome RAIDER RAPID FIRE CS-35 blaster and its special drum! Giving it the highest dart capacity yet, the drum hold 35 darts and features a clear window to let you know when your ammo's getting low. A pump-action handle lets you control your rate of ......More
Are you ready for some serious action? You will be with the RAYVEN CS-18 blaster! The acceleration trigger on this 18-dart blaster lets you fire off your whole clip with semi-automatic speed and, like most N-STRIKE blasters, the Tactical Rail lets you add Tactical Rail accessories (sold separately) ......More
Don't be caught off guard! Be ready, no matter where or when your opponent strikes, with this awesome Tactical Vest Kit. Built to carry four Quick-Reload Clips, 12 darts, blasters and swords, your vest isn't just an accessory -- it's a line of defense! This kit comes with two clear clips ......More
With this awesome, air-powered dart blaster, a "long shot" is a good thing! Measuring three feet long, this blaster is the longest NERF blaster yet and fires up to 35 feet. Attach the barrel extension for long-range targeting and use the tactical rails and flip-up sight to help you zero-in ......More
With this awesome, air-powered dart blaster, a "long shot" is a good thing! Measuring three feet long, this blaster is the longest NERF blaster yet and fires up to 35 feet. Attach the barrel extension for long-range targeting and use the tactical rails and flip-up sight to help you zero-in on ......More


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(Reuters) - Texas Rangers pitcher Yu Darvish and St. Louis Cardinals third baseman David Freese are headed to their first All-Star Game after winning a fan vote that ended on Thursday to complete rosters for Tuesday's game in Kansas City.
Darvish, who left Japan to join Major League Baseball this season, became the eighth Texas player on the 34-man American League (AL) squad that will be managed by Ron Washington of the 2011 AL champion Rangers.
Freese, named Most Valuable Player of the World Series for the triumphant Cardinals, will be reunited with former St. Louis manager, Tony La Russa, who is coming out of retirement to manage the National League in the Midsummer Classic.
Darvish has posted a record of 10-5 with a 3.59 earned run average for the AL-West leading Rangers. In 102-2/3 innings, the right-hander has allowed just 87 hits while striking out 117.
"He has a lot of pride and he is very determined," Rangers president and Hall of Fame pitcher Nolan Ryan said of Darvish. "I truly believe he wants to be one of the best pitchers in the major leagues."
Freese is batting .285, with 13 home runs and 50 runs batted in.
"It's St. Louis," Freese said of the huge support he received from Redbird Nation. "They love Cardinal baseball."
Some 46 million votes were cast online to decide the final roster berths.
(Reporting by Larry Fine in New York; Editing by Frank Pingue)


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The Kayan Mentarang area (Kalimantan Timur, Indonesia) is one of Indonesia's largest (1.6 million hectares) and biologically richest protected areas.
Parts of the reserve are the traditional homelands of several ethnic groups, who are sensitive to their natural environment and have extensive knowledge of the forest resources. The main conservation problems for the area are caused by conflicting interests of different groups involved in using the protected area: logging, forest clearance for commercial farming, protection of biodiversity, conflicts over park boundaries and extraction of valuable forest products by outsiders. The project intends to help the forestry authorities and local communities to set up a management system for the reserve, which includes the creation of various management and buffer zones.


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Miss Me Sequin Wave Straight Stretch Jean
SALE $69.97 was $109.00 Item #57030JE1044T- Lowrise zip fly stretch jean
- Slim fit that is straight through the hip and thigh
- 14" bottom opening
- Sequin and embroidered back flap pockets
- Grinding, tacking, dremmeling and hand sanding details
- Leather Miss Me logo label on back
Miss Me Sequin Wave Straight Stretch Jean 2 2
LOVE!!! These are different from the typical jean, and they're great for those days that you really just want to wear a plan colored top, but not feel too monochromatic! One of the girls was wearing these when I went in to go shopping and she had me try them on, SO happy I did! They are a bit more snug that my other pairs, but you won't have to wash them as often because they take a little longer to stretch out. I bought my normal 29 because even when I tried the 30, those were significantly bigger. Definitely happy with these, the wash and pocket detailing are perfect! December 7, 2011
love them love these jeans, i usually try on several pairs before i find ones i like so ordering on line is something i never do, so when the package came i was so excited to try them on and find they fit perfectly!! love them and hope i have this good of luck next time i order November 27, 2011
1-2 of 2


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1040 Central
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Tuesday December 17, 2013 @06:46PM
Swedish Man Fined $650,000 For Sharing 1 Movie, Charged Extra For Low Quality
Tuesday December 17, 2013 @12:14PM
Judge: NSA Phone Program Likely Unconstitutional
Monday December 16, 2013 @06:08PM
Google Seeks To Throw Out UK Safari Tracking Suit
Saturday December 14, 2013 @01:58PM
Investor Lawsuit Blames NSA For $12B Loss In IBM Value
Thursday December 12, 2013 @09:52AM
EU Advocate General Says EU Data Retention Directive Unlawful
Thursday December 12, 2013 @09:02AM
Chimpanzee "Personhood" Lawsuits Fail In New York Courts
Wednesday December 11, 2013 @06:17PM
Decades-Old Rambus Litigation Against Micron For RDRAM Tech Reaches Settlement
Wednesday December 11, 2013 @11:36AM
California Man Arrested for Running 'Revenge Porn' Website
Friday December 06, 2013 @01:24PM
Supreme Court To Review Software Patents
Thursday December 05, 2013 @10:14AM
eBay Founder Pleads For Leniency For the PayPal 14
Wednesday December 04, 2013 @09:52PM
Tech Companies Set To Appeal 2012 Oracle Vs. Google Ruling
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Wednesday December 04, 2013 @11:13AM
Hotfile Settles With MPAA, Drops Countersuit Against Warner Bros
Wednesday December 04, 2013 @10:42AM
Anonymous Member Sentenced For Joining DDoS Attack For One Minute
Monday December 02, 2013 @09:20PM
Lawsuits Seek To Turn Chimpanzees Into Legal Persons
Monday December 02, 2013 @01:42PM
Supreme Court Declines Case On Making Online Retailers Collect Sales Taxes
Friday November 29, 2013 @03:26PM
Woman Fined For Bad Review Striking Back In Court
Friday November 29, 2013 @10:24AM
French Court Orders Search Engines, ISPs To Block Pirate Sites
Tuesday November 26, 2013 @02:27PM
Jury Finds Newegg Infringed Patent, Owes $2.3 Million
Sunday November 24, 2013 @09:09PM
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Thursday November 21, 2013 @04:37PM
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Thursday November 21, 2013 @02:53PM
Sweden Will Deliver Pirate Bay Co-Founder To Denmark
Tuesday November 19, 2013 @02:50PM
Warner Bros. Admits To Issuing Bogus Takedowns
Monday November 18, 2013 @11:57AM
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Friday November 15, 2013 @01:35PM
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Thursday November 14, 2013 @02:52PM
Google Books Case Dismissed On Fair Use Grounds
Thursday November 14, 2013 @02:12PM
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Thursday November 14, 2013 @09:16AM
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Tuesday November 12, 2013 @01:58PM
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Chicago State University Lawyers Attack Faculty Bloggers
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French Court Orders Google To Block Pictures of Ex-F1 Chief Mosley
Wednesday October 30, 2013 @01:10PM
RIAA Targets 21 Sites For Shutdown
Tuesday October 29, 2013 @03:08PM
Toyota's Killer Firmware
Monday October 28, 2013 @11:29AM
Anti-Poaching Lawsuit Against Apple, Google and Others Given the Green Light
Saturday October 26, 2013 @05:45PM
Federal Prosecutors, In a Policy Shift, Cite Warrantless Wiretaps As Evidence
Saturday October 26, 2013 @03:14PM
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Friday October 25, 2013 @06:17AM
Facebook Faces PRISM Data Investigation In Ireland
Thursday October 24, 2013 @08:15AM
Finally, a Bill To End Patent Trolling
Tuesday October 22, 2013 @09:11PM
Court Rules Probable-Cause Warrant Required For GPS Trackers
Tuesday October 22, 2013 @10:04AM
Call Yourself a Hacker, Lose Your 4th Amendment Rights
Monday October 21, 2013 @04:14AM
Open Rights Group International Says Virgin, Sky Blocking Innocent Sites
Thursday October 17, 2013 @10:01PM
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Thursday October 17, 2013 @01:04PM
IsoHunt Settles With MPAA, Will Shut Down And Pay Up to $110 Million
Wednesday October 16, 2013 @06:41PM
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Saturday September 21, 2013 @07:58AM
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Thursday September 19, 2013 @11:32AM
Charles Carreon Finally Surrenders To the Oatmeal
Wednesday September 18, 2013 @08:27AM
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Monday September 16, 2013 @10:17PM
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Saturday September 14, 2013 @10:48PM
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Bradley Manning Says He's Sorry
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Bradley Manning Convicted of Espionage, Acquitted of 'Aiding the Enemy'
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Boston Marathon Bomber Charged With Using 'Weapon of Mass Destruction'
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Supreme Court Overturns Defense of Marriage Act
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Formlabs In Settlement Talks Over 3D Printing Patent Lawsuit
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Google Files First Amendment Challenge Against FISA Gag Order
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Supreme Court Decides Your Silence May Be Used Against You
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U.S. District Judge: Forced Decryption of Hard Drives Violates Fifth Amendment
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Jeremy Hammond of LulzSec Pleads Guilty To Stratfor Attack
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Judge Thinks Apple Will Lose E-Book Price-Fixing Case
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Curiosity Rewarded: Florida Teen Heading to Space Camp, Not Jail
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Kim Dotcom Wants Money From Google, Twitter For 2-Factor Authentication
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Motion To Delay Sanctions Against Prenda Lawyers Denied
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Groklaw Turns Ten
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Federal Judge Dismisses Movie Piracy Complaint
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In Germany, Offensive Autocomplete Is No Laughing Matter
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- Holly Michaels
Holly Michaels
Holly Michaels is an all natural beauty who started in the adult industry in 2011 at the age of 20. She quickly became a popular box cover girl gracing some of the sexiest titles released. She has a tattoo of a lipstick kiss on her lower abdomen.
Holly Michaels is well known for her girl next door smile and beautiful brown eyes.
Born: 08/16/1990
Phoenix, Arizona
Measurements: 32D-24-34
Eye Color: Brown
Hair Color: Brown


text:
The Martha's Vineyard Land Bank reported revenues of $63,952 for the business week ending on Friday, Feb. 1, 2013. The land bank receives its funds from a two per cent fee charged on many Vineyard real estate transactions.
Much of the land bank revenue last week came from the town of Edgartown, where 11 transactions resulted in $32,632. In Tisbury, two eligible transactions yielded $24,320. One transaction in Oak Bluffs generated $7,000. No eligible transactions were recorded in Aquinnah, Chilmark or West Tisbury. The land bank uses its revenues to purchase and manage land for purposes of conservation, preservation and passive recreation. To date the agency has participated in the purchase of more than 3,018 acres of Vineyard land.


text:
A mounding plant with a lovely shape, its name refers to its graceful spray of foliage and late-summer plumes of fuzzy flowers. The white, pink or red plumes (according to variety) continue into fall and bring an informal look to gardens. Some Pennisetum self seed freely, which means they can become invasive. Although some species will reach 5 feet in height, the dwarf types like 'Hameln' generally stay below 3 feet. 'Purpureum' is grown as an annual in cool climates but has lovely purple leaves and crimson flowers.
Size: 10 inches to 5 feet tall and 1-4 feet wide, depending on varietyConditions: full sun and well-drained soilZones: 5-9Best for: its graceful arching shape and plumes
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Isabel met us where the taxi dropped us at the Bab Doukala mosque and guided us the few minutes walk to her beautifully renovated riad, built around a courtyard with fountain. Our room was lovely, comfortable beds, great bathroom, huge bowl of roses, everything one could wish. Breakfast was a highlight, eaten in a beautifully decorated dining room, and different... More
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text:
A deceased person you wish you could talk to.
told you they'd be random and spontaneous :D.
Dear Beauty,
I know your name isn't really beauty but ever since I was little I always called you that because I thought you looked a lot like Belle from Beauty and the Beast. I love you so much and I wish you were still with us because you were always the life of the party and always had a story or a joke to make someone laugh. You also always knew what I wanted for my birthday and always knew how to cheer me up. You listened when everyone else wasn't and you cared when no one else did.
The rest of the world didn't see you as the good person that you were but I did.
I miss you so so so so much.
James N. Davis
Theme made by Max Davis.


text:
The AKAI APC20 is a MIDI controller, which has controls that light up on it. The lights correspond to the status of a clip in Ableton, but is there any way to change these lights by issuing MIDI commands to the controller using another device (ie. my laptop)?
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Absolutely. That is how it works. See http://www.cycling74.com/forums/topic.php?id=20355#post-106507 for basic mapping information. Basically, different velocities are for different LED colors. | |||


text:
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text:
Susan Keith Gray
Susan Gray
Music, College of Fine Arts
UFA Warren M. Lee Center for the Fine Arts 132
Phone: 605-677-5725
Email: email@example.com
An acclaimed performer and teacher, Susan Keith Gray is a member of the Rawlins Piano Trio and the Kobayashi/Gray Duo. She teaches piano and pedagogy and is the Director of the Master of Music in Collaborative Piano.
Teaching Interests:
Piano, Collaborative Piano
Research Interests:
Collaborative Piano
Piano Performance
Piano Pedagogy
Music of Women Composers
- DMA, Piano Performance: Chamber Music and Accompanying, The University of Michigan, 1990
- Master of Music, Piano Performance, The University of Illinois, 1981
- Bachelor of Music, Piano Performance, Converse College, 1979
- Touring Arts Roster, Rawlins Piano Trio, South Dakota Arts Council, (2012 - 2014)
Awards and Honors:
- Nomination (not pursued), Knutson Distinguished Professor, 2012
- Annual Research Award Nomination (not pursued), USD Office of Research and Sponsored Programs, 2010
- Belbas Award for Excellence in Teaching, University of South Dakota, 2005


text:
'suitable from birth - 10kg'
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Rebecca Taylor
Crepe Georgette Flutter Top
The Rebecca Taylor collection is best known for providing the eternally evolving modern girl with fresh, feminine clothing to complement and refine her individual sense of style. Playful use of color, prints and textures in silhouettes that enhance a spirited lifestyle have cultivated a vast celebrity clientele to include Reese Witherspoon, Katherine Heigl, Rachel Bilson, Sarah Michelle Gellar, Nicole Richie, and Vanessa Hudgens, to name a few. Through a series of collaborations and partnerships, the collection has grown to offer handbags, shoes, jewelry, eyewear and swim.
- 100% poly
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- Modeled in size 2. See fit guide for model's dimensions.
- Revolve Style No. RT-WS484
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text:
Protein–protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein components organised by their protein–protein interactions. Protein interactions have been studied from the perspectives of biochemistry, quantum chemistry, molecular dynamics, chemical biology, signal transduction and other metabolic or genetic/epigenetic networks. Indeed, protein–protein interactions are at the core of the entire interactomics system of any living cell.
Interactions between proteins are important for the majority of biological functions. For example, signals from the exterior of a cell are mediated to the inside of that cell by protein–protein interactions of the signaling molecules. This process, called signal transduction, plays a fundamental role in many biological processes and in many diseases (e.g. cancers). Proteins might interact for a long time to form part of a protein complex, a protein may be carrying another protein (for example, from cytoplasm to nucleus or vice versa in the case of the nuclear pore importins), or a protein may interact briefly with another protein just to modify it (for example, a protein kinase will add a phosphate to a target protein). This modification of proteins can itself change protein–protein interactions. For example, some proteins with SH2 domains only bind to other proteins when they are phosphorylated on the amino acid tyrosine while bromodomains specifically recognise acetylated lysines. In conclusion, protein–protein interactions are of central importance for virtually every process in a living cell. Information about these interactions improves our understanding of diseases and can provide the basis for new therapeutic approaches.
Methods to investigate protein–protein interactions[edit]
As protein–protein interactions are so important there are a multitude of methods to detect them.[1] Each of the approaches has its own strengths and weaknesses, especially with regard to the sensitivity and specificity of the method. A high sensitivity means that many of the interactions that occur in reality are detected by the screen. A high specificity indicates that most of the interactions detected by the screen are also occurring in reality.
High-throughput detection methods include yeast two-hybrid screening and affinity capture mass spectrometry. Yeast two hybrid screens allow for interactions between proteins that are never expressed in the same time and place, lowering the specificity of this method; affinity capture mass spectrometry does not have this drawback. Yeast two-hybrid data better indicates non-specific tendencies towards sticky interactions rather while affinity capture mass spectrometry better indicates functional in vivo protein–protein interactions.[2]
The structures of many protein complexes have been unlocked by the technique of X-ray crystallography.[3] Whereas many high throughput techniques to investigate protein interactions can only tell you which protein interacts with which other proteins, molecular structure can give fine details about which specific parts are interacting and what kinds of chemical bonds mediate that interaction. One of the earliest protein structures to be solved was that of haemoglobin by Perutz and colleagues, which is a complex of four proteins: two alpha chains and two beta chains.[4] As the number of structures available for protein complexes grew researchers began to investigate the underlying principles of protein–protein interactions. Based on just three structures of the insulin dimer, trypsin-pancreatic trypsin inhibitor complex and oxyhaemoglobin, Cyrus Chothia and Joel Janin found that between 1,130 and 1,720 Angstroms2 of surface area was removed from contact with water indicating that hydrophobicity was the major factor stabilising protein–protein interactions.[5] Later studies refined the buried surface area of the majority of interactions to be 1,600±350 Angstroms2. However, much larger interaction interfaces were observed that were associated with large changes in conformation of one of the interaction partners.[3]
Visualization of networks[edit]
Visualization of protein–protein interaction networks is a popular application of scientific visualization techniques.[6] Although protein interaction diagrams are common in textbooks, diagrams of whole cell protein interaction networks were not as common since the level of complexity made them difficult to generate. One example of a manually produced molecular interaction map is Kurt Kohn's 1999 map of cell cycle control.[7]
Drawing on Kohn's map, in 2000 Schwikowski et al. published a paper on protein–protein interactions in yeast, linking together 1,548 interacting proteins determined by two-hybrid testing. They used a layered graph drawing method to find an initial placement of the nodes and then improved the layout using a force-based algorithm.[8][9][10]
The Cytoscape software is a widely used application to visualise protein–protein interaction networks.[11]
Database collections[edit]
Methods for identifying interacting proteins have defined hundreds of thousands of interactions. These interactions are collected together in specialised biological databases that allow the interactions to be assembled and studied further. The first of these databases was DIP, the database of interacting proteins.[12] Since that time a large number of further database collections have been created such as BioGRID, FunCoup, STRING and ConsensusPathDB.
See also[edit]
- Interactome
- Interactomics
- Fuzzy complex
- Complex systems biology
- Protein–protein interaction prediction
- Protein–protein interaction screening
- Types of protein–protein interactions
- ^ Phizicky, E. M.; Fields, S. (1995). "Protein-protein interactions: Methods for detection and analysis". Microbiological reviews 59 (1): 94–123. PMC 239356. PMID 7708014.
- ^ Brettner, L. M.; Masel, J. (2012). "Protein stickiness, rather than number of functional protein-protein interactions, predicts expression noise and plasticity in yeast". BMC Systems Biology 6: 128. doi:10.1186/1752-0509-6-128. PMC 3527306. PMID 23017156.
- ^ a b Janin, J.; Chothia, C. (1990). "The structure of protein-protein recognition sites". The Journal of biological chemistry 265 (27): 16027–16030. PMID 2204619.
- ^ Perutz, M. F.; Rossmann, M. G.; Cullis, A. F.; Muirhead, H.; Will, G.; North, A. C. (1960). "Structure of haemoglobin: A three-dimensional Fourier synthesis at 5.5-A. Resolution, obtained by X-ray analysis". Nature 185 (4711): 416–422. doi:10.1038/185416a0. PMID 18990801.
- ^ Chothia, C.; Janin, J. (1975). "Principles of protein-protein recognition". Nature 256 (5520): 705–708. doi:10.1038/256705a0. PMID 1153006.
- ^ De Las Rivas, J.; Fontanillo, C. (2010). "Protein–Protein Interactions Essentials: Key Concepts to Building and Analyzing Interactome Networks". In Lewitter, Fran. PLoS Computational Biology 6 (6): e1000807. doi:10.1371/journal.pcbi.1000807. PMC 2891586. PMID 20589078.
- ^ Kohn, K. W. (1999). "Molecular interaction map of the mammalian cell cycle control and DNA repair systems". Molecular biology of the cell 10 (8): 2703–2734. PMC 25504. PMID 10436023.
- ^ Schwikowski, B.; Uetz, P.; Fields, S. (2000). "A network of protein-protein interactions in yeast". Nature Biotechnology 18 (12): 1257–1261. doi:10.1038/82360. PMID 11101803.
- ^ Rigaut, G.; Shevchenko, A.; Rutz, B.; Wilm, M.; Mann, M.; Séraphin, B. (1999). "A generic protein purification method for protein complex characterization and proteome exploration". Nature Biotechnology 17 (10): 1030–1032. doi:10.1038/13732. PMID 10504710.
- ^ Prieto, C.; De Las Rivas, J. (2006). "APID: Agile Protein Interaction DataAnalyzer". Nucleic Acids Research 34 (Web Server issue): W298–W302. doi:10.1093/nar/gkl128. PMC 1538863. PMID 16845013.
- ^ Michael Kohl, Sebastian Wiese, and Bettina Warscheid (2011) Cytoscape: Software for Visualization and Analysis of Biological Networks. In: Michael Hamacher et al. (eds.), Data Mining in Proteomics: From Standards to Applications, Methods in Molecular Biology, vol. 696, DOI 10.1007/978-1-60761-987-1_18
- ^ Xenarios, I.; Rice, D. W.; Salwinski, L.; Baron, M. K.; Marcotte, E. M.; Eisenberg, D. (2000). "DIP: The database of interacting proteins". Nucleic acids research 28 (1): 289–291. doi:10.1093/nar/28.1.289. PMC 102387. PMID 10592249.
External links[edit]
Library resources about Protein–protein interaction |
- Calculating protein–DNA binding maps for chromatin
- Proteins and Enzymes at the Open Directory Project
- Casado-Vela J, Matthiesen R, Sellés S, Naranjo, JR Protein-Protein Interactions: Gene Acronym Redundancies and Current Limitations Precluding Automated Data Integration Proteomes 2013, 1(1), 3-24.


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Most people stereotype this as women being the victims because its what it has been seen as in society for many many years, for many years, women were seen as inferior, whereas it is becoming more and more apparently that nowadays there is more abuse with men being the victims. Any type of abuse where any human is demoralised is wrong, its a act that could destroy a person for life. It can make them enter a cycle that will always be a huge part of their life, and it is a shame that some people don't realise what they are doing is wrong, and the victims feel too powerless to do something about it. Its good that more awareness has been made about it.
ReplyJammiedodger128 - 25/04/2012


text: "En garde!" You're quick with your blade and quicker with your tongue. Your enemies are numerous and waiting for a weakness. Do you spend your days watching the shadows? Or call them out on the field of honor and settle things once and for all? You've lost your daughter to brutal kidnappers. The authorities can do nothing to help. Do you accede to the thugs' demand... [click here for more]


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Could you be a victim of PTSD? You can make peace with it, and get help, and take charge of your healing.
When boomers were little, we had a plethora of toys. But we were the first generation like that. Here's some background.
Do you want to stay young and agile? Get flexible, and get flexible by stretching. Baby boomer Mike McGuire shows us how.
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If there is a single year that changed our generation and our world, it was 1968 and Larry Checco was there.