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Updates to the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection were released on Thursday, November 1, 2012. Please send your comments to firstname.lastname@example.com by November 15, 2012.
Corrections were made to the guideline. For a description of the changes, please see the correction notice.
(Last updated:11/1/2012; last reviewed:11/1/2012)
The decision on when to initiate antiretroviral therapy (ART) in asymptomatic HIV-infected older children, adolescents, and adults continues to generate controversy among HIV experts. Aggressive therapy in the early stages of HIV infection has the potential to control viral replication before the evolution of HIV in that individual into a diverse and potentially more pathogenic quasispecies. Initiation of therapy at higher CD4 T lymphocyte (CD4 cell) counts has been associated with fewer drug resistance mutations at virologic failure in adults.1 Early therapy also slows immune system destruction and preserves immune function, preventing clinical disease progression.2 Ongoing viral replication may be associated with persistent inflammation and development of cardiovascular, kidney, and liver disease and malignancy; studies in adults suggest that early control of replication may reduce the occurrence of these non-AIDS complications.2-8 In addition, data from a large randomized multinational clinical trial of HIV-serodiscordant adults demonstrated that effective ART reduced secondary transmission to an uninfected sexual partner by 96%.9 Conversely, delaying therapy until later in the course of HIV infection, when clinical or immunologic symptoms appear, may result in reduced evolution of drug-resistant virus due to a lack of drug selection pressure, improved adherence to the therapeutic regimen because the patient is symptomatic, and reduced or delayed adverse effects of ART. Because therapy in children is initiated at a young age and will likely be lifelong, concerns about adherence and toxicities are particularly important.
The Health and Human Services (HHS) Adult and Adolescent Antiretroviral Guidelines Panel now recommends initiation of therapy for all adults with HIV infection, with the proviso that the strength of the recommendations is dependent on the pre-treatment CD4 cell count.10 Randomized clinical trials have provided definitive evidence of benefit with initiation of therapy in adults with CD4 cell counts <350 cells/mm3.11 Observational cohort data have demonstrated the benefit of treatment in adults with CD4 cell counts between 350 and 500 cells/mm3 in reducing morbidity and mortality; therefore, adult treatment guidelines recommend initiation of lifelong ART for individuals with CD4 cell counts ≤500 cells/mm3.10,12-15 For adults with CD4 counts >500 cell/mm3, observational data are less conclusive regarding the potential survival benefit of early treatment.12,13,16 The recommendation for initiation of therapy at CD4 counts >500/mm3 (BIII evidence) in adults is based on accumulating data that untreated HIV infection may be associated with development of many non-AIDS-defining diseases, the availability of more effective ART regimens with improved tolerability, and evidence that effective ART reduces sexual HIV transmission. However, the Adult Guidelines Panel acknowledges that the amount of data supporting earlier initiation of therapy decreases as the CD4 cell count increases above 500 cells/mm3, and that concerns remain over the unknown overall benefit, long-term risks, cumulative additional costs, and potential for decreased medication adherence associated with earlier treatment in asymptomatic patients.10
Treatment Recommendations for Initiation of Therapy in Antiretroviral-Naive HIV-Infected Infants and Children
Panel's Recommendations
Infants Younger than 12 Months of Age
The Children with HIV Early Antiretroviral Therapy (CHER) Trial, a randomized clinical trial in South Africa, demonstrated that initiating triple-drug, antiretroviral therapy (ART) before age 12 weeks in asymptomatic perinatally infected infants with normal CD4 percentage (>25%) resulted in a 75% reduction in early mortality, compared with delaying treatment until the infants met clinical or immune criteria.17 Most of the deaths in the infants in the delayed treatment arm occurred in the first 6 months after study entry. Because the risk of rapid progression is so high in young infants and based on the data in young infants from the CHER study, the Panel recommends initiating therapy for all infants age <12 months regardless of clinical status, CD4 percentage, or viral load (Table 7). Before therapy is initiated, it is important to fully assess, discuss, and address issues associated with adherence with an HIV-infected infant's caregivers. However, given the high risk of disease progression and mortality in young HIV-infected infants, it is important to expedite this assessment in infants <12 months of age.
The risk of disease progression is inversely correlated with the age of a child, with the youngest infants at greatest risk of rapid disease progression. Progression to moderate or severe immune suppression is also frequent in older infected infants; by age 12 months, approximately 50% of children develop moderate immune suppression and 20% develop severe immune suppression.18 In the HIV Paediatric Prognostic Markers Collaborative Study meta-analysis, the 1-year risk of AIDS or death was substantially higher in younger children than in older children at any given level of CD4 percentage, particularly for infants <12 months of age.19 Unfortunately, although the risk of progression is greatest in the first year of life, the ability to differentiate children at risk of rapid versus slower disease progression by clinical and laboratory parameters is also most limited in young infants. No specific "at-risk" viral or immunologic threshold can be easily identified, and progression of HIV disease and opportunistic infections (OIs) can occur in young infants with normal CD4 cellcounts.19
Identification of HIV infection during the first few months of life permits clinicians to initiate ART during the initial phases of primary infection. Data from a number of observational studies in the United States and Europe suggest that infants who receive early treatment are less likely to progress to AIDS or death than those who start therapy later.2,20-23 Several small studies have demonstrated that, despite the very high levels of viral replication in perinatally infected infants, early initiation of treatment can result in durable viral suppression and normalization of immunologic responses to non-HIV antigens in some infants.24,25 In infants with sustained control of plasma viremia, failure to detect extra-chromosomal replication intermediates suggests near-complete control of viral replication. Some of these infants have become HIV seronegative. Therapy is not curative, however, as proviral HIV-1 DNA continues to be detectable in peripheral blood lymphocytes and viral replication resumes if therapy is discontinued.26,27
However, virologic suppression may take longer to achieve in young children than in older children or adults.28,29 Possible reasons for the poor response in infants include higher virologic set points in young infants, inadequate antiretroviral (ARV) drug levels, and poor adherence because of the difficulties in administering complex regimens to infants. With currently available drug regimens, rates of viral suppression of 70% to 80% have been reported in HIV-infected infants initiating therapy at <12 months of age.2,30,31 In a 5-year follow-up study of 40 HIV-infected children who initiated treatment at <6 months of age, 98% had CD4 percentage >25% and 78% had undetectable viral load with median follow-up of 5.96 years.2
Information on appropriate drug dosing in infants younger than 3 to 6 months is limited. Hepatic and renal functions are immature in newborns undergoing rapid maturational changes during the first few months of life, which can result in substantial differences in ARV dose requirements between young infants and older children.32 When drug concentrations are subtherapeutic, either because of inadequate dosing, poor absorption, or incomplete adherence, ARV drug resistance can develop rapidly, particularly in the setting of high levels of viral replication in young infants. Frequent follow-up and continued assessment and support of adherence are especially important when treating young infants (see Adherence to Antiretroviral Therapy in HIV-Infected Children and Adolescents).
Finally, the possibility of toxicities—such as lipodystrophy, dyslipidemia, glucose intolerance, osteopenia, and mitochondrial dysfunction—with prolonged therapy is a concern.33 A clinical trial in South Africa is assessing whether it may be possible to stop therapy begun in infancy after a defined duration of treatment that protects a child during the period of greatest risk of HIV disease progression and mortality (such as 1 to 2 years) and then restart therapy when a child meets standard age-related criteria.
Children 1 Year of Age and Older
Disease progression is less rapid in children aged ≥1 year.18 Children with clinical AIDS or significant symptoms (Clinical Category C or B—Table 6)34 are at high risk of disease progression and death. The Panel recommends treatment for all such children, regardless of immunologic or virologic status. However, children aged ≥1 year who have mild clinical symptoms (Clinical Category A) or who are asymptomatic (Clinical Category N) are at lower risk of disease progression than children with more severe clinical symptoms.35 It should also be noted that some Clinical Category B conditions, such as a single episode of serious bacterial infection, may be less prognostic of the risk of disease progression. Consideration of CD4 cell count and viral load may be useful in determining the need for therapy in children with these conditions.
In adults, the strength of recommendations to initiate ART in asymptomatic individuals is based primarily on risk of disease progression, as determined by baseline CD4 cell count.10 In adults, both clinical trial and observational data support initiation of treatment in individuals with CD4 cell counts <350 cells/mm3. In HIV-infected adults in Haiti, a randomized clinical trial found significant reductions in mortality and morbidity with initiation of treatment when CD4 cell counts fell to <350 cells/mm3, compared with deferring treatment until CD4 cell counts fell to <200 cells/mm3.11 In observational data in adults, a collaborative analysis of data from 12 adult cohorts in North America and Europe on 20,379 adults starting treatment between 1995 and 2003, the risk of AIDS or death was significantly less in adults who started treatment with CD4 cell counts of 200 to 350 cells/mm3 compared with those who started therapy at CD4 cell counts <200 cells/mm3.36
No randomized trial data exist to address the comparative efficacy of starting versus deferring treatment at higher CD4 thresholds in HIV-infected adults or children. Two observational studies in adults—the ART Cohort Collaboration (ART-CC) and North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD)—suggest a higher rate of progression to AIDS or death in patients deferring treatment until CD4 count is <350 cells/mm3 compared with patients starting ART at CD4 cell counts of 351 to 500 cells/mm3.12,13 The NA-ACCORD study demonstrated a benefit of starting treatment at CD4 cell counts >500 cell/mm3 compared with starting ART at CD4 cell counts below this threshold;12 however the ART-CC cohort found no additional benefit for patients starting ART with CD4 cell counts >450 cells/mm3.13 In a third observational study of 5,162 patients with CD4 cell counts between 500 to 799 cells/mm3, patients who started ART immediately did not experience a significant reduction in progression to AIDS or death (HR: 1.10, 95% CI: 0.67 to 1.79) or death alone (HR: 1.02, 95% CI: 0.49 to 2.12), compared with those who deferred therapy.15 There are no similar observational data analyses for HIV-infected children. In children, the prognostic significance of a specific CD4 percentage or count varies with age.19,37 In data from the HIV Paediatric Prognostic Markers Collaborative Study meta-analysis, derived from 3,941 children with 7,297 child-years of follow-up, the risk of mortality or progression to AIDS per 100 child-years is significantly higher for any given CD4 count in children aged 1 to 4 years than in children aged ≥5 years (Tables 3–4 and Figures 1–2). Data from the HIV Paediatric Prognostic Markers Collaborative Study suggest that absolute CD4 cell count is a useful prognostic marker for disease progression in children age ≥5 years, with risk of progression similar to that observed in adults (Table 4).19,38 For children age 1 to <5 years, a similar increase in risk of AIDS or death is seen when CD4 percentage drops below 25% (Table 3).
Because the CD4 percentage is more consistent than the naturally declining CD4 cell count in the first years of life, it has been used preferentially to monitor immunologic status in children <5 years of age. However, an analysis of >21,000 pairs of CD4 measurements from 3,345 children <1 to 16 years of age in the HIV Paediatric Prognostic Markers Collaborative Study found that CD4 cell counts and percentages were frequently discordant around established World Health Organization (WHO) and the Pediatric European Network for Treatment of AIDS (PENTA) thresholds for initiation of ART (14% and 21%, respectively).39 Furthermore, CD4 cell counts were found to provide greater prognostic value over CD4 percentage for short-term disease progression for children <5 years as well as in older children. For example, the estimated hazard ratio for AIDS or death at the 10th centile of CD4 cell count (compared with the 50th centile) was 2.2 (95% confidence interval [CI]) 1.4, 3.0) for children 1 to 2 years of age versus 1.2 (CI 0.8, 1.6) for CD4 percentage. Therefore, the updated pediatric guidelines include CD4 cell count thresholds (which differ for children aged 1 to <3, 3 to 5, and ≥5 years due to age-related changes in absolute CD4 cell count) as well as CD4 percentage thresholds for all children >12 months of age. In the case of discordance between CD4 cell counts and percentages, decisions should be based on the lower value.
The level of plasma HIV RNA may provide useful information in terms of risk of progression, although its prognostic significance is weaker than CD4 count.37 Several studies have shown that older children with HIV RNA levels ≥100,000 copies/mL are at high risk of mortality40-42 and lower neurocognitive performance;43 similar findings have been reported in adults.44-46 Similarly, in the HIV Paediatric Prognostic Markers Collaborative Study meta-analysis, the 1-year risk of progression to AIDS or death rose sharply for children aged >1 year when HIV RNA levels were ≥100,000 copies/mL (Table 3 and Figures 4–5).37 For example, the estimated 1-year risk of death was 2 to 3 times higher in children with plasma HIV RNA of 100,000 copies/mL compared with 10,000 copies/mL and 8 to 10 times higher with plasma HIV RNA >1,000,000 copies/mL.
As with data in adults, data from pediatric studies suggest that improvement in immunologic parameters is better in children when treatment is initiated at higher CD4 percentage/count levels.29,47-51 In a study of 1,236 perinatally infected children in the United States, only 36% of those who started treatment with CD4 percentage <15% and 59% of those starting with CD4 percentage 15% to 24% achieved CD4 percentage >25% after 5 years of therapy.52 Younger age at initiation of therapy has also been associated with improved immune response and with more rapid growth reconstitution.47,52,53 Given that disease progression in children aged ≥5 years is similar to that in adults,38 and observational data in adults show decreased risk of mortality with initiation of therapy when CD4 cell count is <500 cells/mm3,12,13 most experts feel that recommendations for asymptomatic children in this age range should be similar to those for adults. However, there are no pediatric data to address the optimal CD4 cell count threshold for initiation of therapy in older children; research studies are needed to answer this question in children more definitively. The HHS Adult Treatment Guidelines Committee has moved to endorse initiating ART in all HIV-infected adults regardless of CD4 cell count, using varying strengths of evidence to support different CD4 cell count thresholds10 and incorporating compelling data demonstrating that ART is effective in preventing secondary transmission of HIV. However, prevention of sexual transmission of HIV is not a significant consideration for children <13 years of age. Comparative studies on the impact of treatment versus treatment delay at specific higher CD4 cell counts have not been performed in children, and observational adult studies have produced conflicting results.12,13,16 Drug choices are more limited in children than in adults and adequate data to address the potential long-term toxicities of prolonged ART in a developing child are not yet available. Some studies have shown that a small proportion of perinatally infected children may be long-term nonprogressors, with no immunologic or clinical progression by 10 years of age despite receiving no ART.54-56 Medication adherence is the core requirement for successful virologic control, but enforcing consistent adherence in childhood is often challenging.57 Incomplete adherence leads to the selection of viral resistance mutations but forced administration of ARVs to children may result in treatment aversion or fatigue, which occurs among many perinatally infected children during adolescence.58 The relative benefits of initiating ART in asymptomatic children with low viral burdens and high CD4 cell counts must be weighed against these potential risks.
The Panel recommends that ART should be initiated in all children who have AIDS or significant HIV-related symptoms (CDC Clinical Categories C and B, except for the following Category B condition: single episode of serious bacterial infection [Table 6]), regardless of CD4 percentage/count or HIV RNA level.
The Panel also generally recommends treatment for all children aged ≥1 year with no or mild symptoms (Clinical Categories N and A, or Clinical Category B disease due to a single episode of bacterial infection [Table 6]), with the strength of recommendation differing based on age and CD4 count/percentage. Patients/caregivers may choose to postpone therapy, and, on a case-by-case basis, providers may elect to defer therapy based on clinical and/or psychosocial factors.
Treatment is strongly recommended regardless of HIV RNA level for children aged 1 to <3 years with CD4 cell counts <1000/mm3 OR percentage <25%, and for children 3 to <5 years with CD4 cell counts <750 cells/mm3 OR percentage <25%, based on observational pediatric data.19 Treatment can also be considered for children aged 1 to <3 years with CD4 cell counts ≥1000/mm3 and percentage ≥25% and for children 3 to <5 years with CD4 cell counts ≥750 cells/mm3 and percentage ≥25%, although the strength of the recommendation is lower because of limited data. In these children, plasma HIV RNA levels may be helpful in decision making; plasma HIV RNA >100,000 copies/mL provides higher-rated evidence for treatment, based on pediatric observational data that demonstrate higher mortality risk with high HIV RNA levels.19,59
For children age ≥5 years with no or minimal symptoms, treatment is recommended if CD4 cell counts are ≤500 cells/mm3, regardless of HIV RNA level. The evidence for this recommendation is strongest for children with CD4 cell counts <350 cells/mm3. For children with CD4 cell counts 350–500 cells/mm3, the recommendation is based on observational data in adults and hence the evidence base is not as strong; this recommendation should not prohibit research studies in children designed to answer this question more definitively. Treatment should also be considered for children who are asymptomatic or have mild symptoms with CD4 counts >500 cells/mm3, although the strength of the recommendation is lower because of limited data. Plasma HIV RNA levels may be helpful in decision making, with plasma HIV RNA >100,000 copies/mL providing higher rated evidence for treatment as noted above.19,59
In general, except in infants and children with advanced HIV infection, ART does not need to be started immediately. Before initiating therapy, it is important to take time to educate caregivers (and older children) about regimen adherence and to anticipate and resolve any barriers that might diminish adherence. This is particularly true for children aged ≥5 years given their lower risk of disease progression and the higher CD4 cell count threshold now recommended for initiating therapy.
If therapy is deferred, the health care provider should closely monitor a child's virologic, immunologic, and clinical status (see Laboratory Monitoring of Pediatric HIV Infection). Factors to consider in deciding when to initiate therapy in children in whom treatment was deferred include:
Click here to view this table as an image Table 7 provides general guidance rather than absolute recommendations for individual patients. Factors to be considered in decisions about initiation of therapy include risk of disease progression as determined by CD4 percentage or count and plasma HIV RNA copy number, the potential benefits and risks of therapy, and the ability of the caregiver to adhere to administration of the therapeutic regimen. Before making the decision to initiate therapy, the provider should fully assess, discuss, and address issues associated with adherence with a child (if age appropriate) and the caregiver. Patients/caregivers may choose to postpone therapy, and, on a case-by-case basis, providers may elect to defer therapy based on clinical and/or psychosocial factors.a


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WELCOME TO CALL OF CTHULHU! If you have ever been enthralled by a ghost story or spellbound at a horror movie, you are in for a treat. Part the veil that separates frail humanity from the terror that lurks beyond space and time. Investigate forgotten ruins, haunted woods, and nameless menaces.
Call of Cthulhu is a horror roleplaying game using the Basic Roleplaying system and based upon the writings of Howard Phillips Lovecraft and a few others. Lovecraft wrote during the 1920s and 1930s, and he became a cult figure before dying in 1937. Since then his stature as an author has grown, and now he is generally recognized as the major American horror-story writer of the twentieth century.
When faced with the horrors of the Cthulhu Mythos, investigators need all the help that they can get. This essential player's aid for Call of Cthulhu provides it.
The 1920s Investigator's Companionis split into four sections. "The Roaring Twenties" details life in the 1920s, ... [Klicken Sie hier für weiteres]
The ideas presented in this book attempt to be both mundane and fantastic at the same time— plausability is the key.
It is in the details that the horror lies, because it is in the credibility of the details that the fantastic can rise and stand.
This, then, is a book of details, most mundane, some fantastic. They have but one purpose—that of bringing Lovecraft... [Klicken Sie hier für weiteres]
A Resection of Time is a short campaign for Call of Cthulhu set in the modern day. It begins in early April, in San Francisco, and ends a little later in the steamy jungles of Belize, in Central America. Before plunging into the dark heart of the ancient Mayan world, the investigators also travel to Los Angeles and shadowy Arkham.
The details of Mayan architecture, ... [Klicken Sie hier für weiteres]
ARKHAM NOW updates to modern times the famous and fabled city of Arkham for the Call of Cthulhu roleplaying game.
Most residents believe there is only one horror lurking in this legendary haunted town — the urban sprawl slowly eroding Arkham's old New England beauty. Rushing by neon signs and mega-marts to obtain even more material... [Klicken Sie hier für weiteres]
The batle against the horrors of the myihos often leaves an investigator dead or insane. In either case, a paper trail has formed, one that can lead new, ignorant investigators into realms of unspeakable evil.
This supplement contains a large number of useful forms for use in a Call of Cthulhu® game. Death certificates, insanity certificates, patient records, and even finge... [Klicken Sie hier für weiteres]
Little by little they rose grimly into the western sky; allowing us to witness the various bare, bleak, and blackened summits . . . in the reddish Antarctic lights against the provocative background of iridescent ice-dust clouds. In the whole spectacle there was a persistent, pervasive hint of stupendous secrecy and potential revelation. . . . I c... [Klicken Sie hier für weiteres]
"...and I would have got away with it too if it hadn't been for you meddling investigators and your stupid dog!"
—Frustrated Cultist upon arrest by local authorites.
Do you have gaming buddies coming over tonight and don't know what to wear, or more ... [Klicken Sie hier für weiteres]
9 Glimpses of Horror
"Ooh, those A-li-ens, A-li-ens On a weekend from Mars They liked our girls and our cars- Ooh, those A-li-ens, A-li-ens" —From the Blood Brothers 2 soundtrack.
They're B-movies, they're bad, and they're back for more laughs. Nine scenarios which ha... [Klicken Sie hier für weiteres]
The Great Old Ones ruled the earth aeons before the rise of humankind. Originally they came from the gulfs of space and were cast down by even greater beings. Remains of their cyclopean cities and forbidden knowledge can still be found on remote islands in the Pacific, buried amid the shifting sands of vast deserts, and in the frigid rece... [Klicken Sie hier für weiteres]
The Great Old Ones ruled the earth aeons before the rise of humankind. Originally they came from the gulfs of space and were cast down by even greater beings. Remains of their cyclopean cities and forbidden knowledge can still be found on remote islands in the Pacific, buried amid the shifting sands of vast deserts, and in the frigid reces... [Klicken Sie hier für weiteres]
IN THE 1890s, Cthulhu and his minions share the globe with the mighty British Empire. But they owe allegiance to an empire of their own — a dark and cruel design on ownership of the world and on the dreams of humanity. Even among the green fields of rural England, only thoughtful and energetic intervention keeps the shadows at bay.
Ghastly Adventures & Erudite Lore
This book is composed of submissions to Different Worlds magazine and other Cthulhoid Chaosium projects. The Different Worlds readers' enthusiasm for the Cthulhu Mythos resulted in many excellent submissions, some of which appear, with permission, within these pages.
The contents of this... [Klicken Sie hier für weiteres]
The Dark Ages world is filled with life, death, and the pain of old age. Vengeful hordes wash across the world. Petty warlords fight among themselves like ravenous dogs. Disease runs rampant. Illiterate city-folk and simple farmers dread that which lurks in the dark. And in the greatest abbeys, a few know of forbidden books that speak of... [Klicken Sie hier für weiteres]
A 9th Level Beer and Pretzels Role-Playing Game.* Have you lost all hope in the future? Tired of Big Government? Sick of greedy, corrupt officials? You are not alone! Become one with the Elder Party! The greatest evil in the universe just sunk to new depths, and has announced his intention to enter politics. Don't settle for the lesser evil! Heed... [Klicken Sie hier für weiteres]
ROMAN CHILDREN TREMBLE in their beds as their mothers tell them stories of Medusa, the Hundred-Handed Ones, and the War of the Titans. They pray that the Fates have woven a long skein for them, free from encounters with the Minotaur and Cerberus. Little do they know that things more horrible than the creatures of myth and lege... [Klicken Sie hier für weiteres]
Here are new beasts and creatures for use with the Cthulhu Invictus setting of the Call of Cthulhu role-playing game.
THIS IS A DOWNLOADABLE PRODUCT. Two 8.5x11" pages.
AS ROME'S INFLUENCE SPREADS across the known world, so too spreads the worship of its gods. Roman leaders know that converting the people of conquered regions to the state religion makes them easier to control. But some gods have been worshipped longer than Rome has existed, and their supplicants won't easily change allegiances.
Here are scenario seeds for use with the Cthulhu Invictus setting of the Call of Cthulhu role-playing game.
THIS IS A DOWNLOADABLE PRODUCT. One 8.5x11" page.
Notes on Roman Patronage for use with the Cthulhu Invictus setting of the Call of Cthulhu role-playing game.
Non-player characters for use with the Cthulhu Invictus setting of the Call of Cthulhu role-playing game.
CTHULHU NOW includes four roleplaying adventures, "The City in the Sea," The Killer Out of Space," The Evil Stars," and "Dreams Dark and Deadly." Background essays provide new skills and occupations, up-to-date cash-flow information, an elaborate firearms article (and a foldout illustrating contemporary firearms), active and passive night-vision equipment,... [Klicken Sie hier für weiteres]
Explore the occult in 1890s England. Particularly thorough background notes and unusual plots help keep the investigators on their toes. Streamlined investigator creation for the era: owning Gaslight is not necessary to use this book.
Fatal Experiments is a collection of three independent 1920's adventures for the Call of Cthulhu roleplaying game. Two of the three scenarios are suitable for both beginning and experienced players, making this book a perfect companion for first-time buyers of the Call of Cthulhu game system. The remaining adventure is unusually dangerous -- to be played only by experienced... [Klicken Sie hier für weiteres]
Aircraft - Trains - Automobiles - Dirigibles - Diving Suits - Canal Boats - Armored Cars - Elephants - Siberian Sledges The golden age of travel occurred between 1880-1939. As traveling times shrank, destination became more important than journey, a notion now so conimon-sensical that we blink to think that the reverse was once truer. FEARFUL PASSAGES contains nine adventures s... [Klicken Sie hier für weiteres]
This second Call of Cthulhu companion answers questions common to Call of Cthulhu games, and reveals ancient linguistic traces of the dread Cthulhu cult among various cultures.
It then summarizes all Mythos spells printed in Shadows of Yog-Sothoth, The Asylum, the Cthulhu Companion, The Fungi From Yuggoth, Curse of the Chthonians, Tra... [Klicken Sie hier für weiteres]
This essential supplement for the d20 edition of Call of Cthulhu contains the most important tables & rules synopses to make d20 Cthulhu game sessions easier & more enjoyable for the GM. Includes the 32 page adventure "The Lost temple of Yig", character sheets, NPC records, Monster Sheets, conversion notes between d20 Call of Cthulhu and the Classic Basic Roleplaying Call of C... [Klicken Sie hier für weiteres]
"Behind everything crouched the brooding, festering horror of the ancient town . . . the changeless, legend-haunted city of Arkham, with its clustering gambrel roofs that sway and sag over attics where witches hid from the King's men in the dark, olden days of the Province.
It was always a very bad time in Arkham . . . .">... [Klicken Sie hier für weiteres]
We all dream . . .
For some, dreams can become reality. H.P. Lovecraft's Dreamlands provides everything needed for Call of Cthulhu or Cthulhu Dark Ages investigators to travel down the seven hundred steps, through the Gates of Deeper Slumber, and into the realm of dreams. Includes a travelogue of the Dreamlands, a huge ga... [Klicken Sie hier für weiteres]
For classic Call of Cthulhu and d20 Cthulhu. Dunwich is a small village located along the Miskatonic, upriver from Arkham. Until 1806, Dunwich was a thriving community, boasting many mills and the powerful Whateley family.
Those among the Whateleys came to know dark secrets about the world, and they fell into the worship of unwholesome crea... [Klicken Sie hier für weiteres]
This dangerous investigation is set in Canada, in the 1920s.
The investigators meet the powerful Lavoie family of Montreal and learn what imperils them. They glimpse a strange cult that now thrives in Quebec and the ancient nemesis that guides it. They come to understand the horrible significance of a corpse discovered in the foundations of a former seminary. They at last perceive the t... [Klicken Sie hier für weiteres]
Three Scenarios for Call of Cthulhu
A disappearance.
A plea for help.
The strike of sudden madness.
Fear forms where shadows begin. The Cthulhu Mythos hovers at the edges of reason and sanity. With their courage and intelligence, investigators can dare the unknown and the unknowable, and r... [Klicken Sie hier für weiteres]
Hot Tips, Secret Info, & Sure-Fire Rules
Are there flashlights in the 1920s? How about flashbulbs? What can your licensed private-eye do? Can your investigators buy a machine gun?
Too often, Call of Cthulhu investigators find themselves not only baffled by the mysteries of the Mythos, but baffled as well by day-to-day... [Klicken Sie hier für weiteres]
Occupations & Skills
What, You Want To Live Forever?
Oh, just a little longer and a bit more pleasantly in the face of Mythos horrors. Let this book be your guide.
On becoming an investigator contains valuable tips that can help your investigator reach middle age, and possibly even those golden years. The Occupations Section ... [Klicken Sie hier für weiteres]
Two Gangland Adventures for 1920's Call of Cthulhu.
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Four challenging horrors for today. A book of wretched poetry, an incautious summoning, a Satanic coven, and a house with a suspicious history are the basic ingredients. Useful as stand-alone adventures, or for a change of pace when inserted into an ongoing campaign. Though suitable for beginning player characters, these adventures are dangerous, and incautious beginners will come to regret ras... [Klicken Sie hier für weiteres]
Here are those things which can "eternal lie", and which have lived beyond human understanding for strange aeons. The Cthulhu Mythos is comprised of a complex and broad group of sometimes-contradictory entities, powers, ... [Klicken Sie hier für weiteres]
IN DIM, FORGOTTEN RECESSES of the world lurk mind-twisting horrors. Through the use of human agents these horrors work to thwart mankind's destiny.
However, not all of these human agents are willing partners. Many times have the monsters resorted to subtlety and intrigue to further the... [Klicken Sie hier für weiteres]
At last the stars are almost right!
Soon Nyarlathotep's plans will come to fruition. Then the world will be changed irrevocably — but not quite yet. Pesky human investigators have learned much. Now they must survive long enough to make sense of what they know, and take resolute action.Masks of Nyarlathotep is a ... [Klicken Sie hier für weiteres]
At the Spookiest School In the World
"Some graduation!" you grumble to yourself as you dodge the green tentacles with practiced ease. But what did you expect? You enrolled in mysterious Miskatonic University, an institution created by the internationally famous horror writer, H.P. Lovecraft. As proof. you clutch a diploma and a bundle of sou... [Klicken Sie hier für weiteres]
MISKATONIC UNIVERSITY is a small, seemingly typical New England college nestled in the bosom of conservative Arkham, Massachusetts. A poor cousin to such hallowed institutions as Harvard, Brown, and Princeton (the term "Ivy League" won't come into use until 1936), Miskatonic nonetheless offers coveted degrees in a wide variety of ... [Klicken Sie hier für weiteres]
The world sees Miskatonic University as a solid New England institution. Its professors and departments are on par with those of any Ivy League school—among the best in the nation.
Founded phsthumously in 1765 by seacaptain Jeremiah Orne, Miskatonic University grew from the acquired assets, and debts, of ailing Arkham College. Orne laid claim to the older... [Klicken Sie hier für weiteres]
THE DATE IS OCTOBER 2, 1918. In France, soldiers huddle in hastily-dug trenches, faith their only protection against the never-ending artillery barrage. It is the time of World War I — the Great War — when mankind proves itself capable of atrocities never before conceived. As above, so below. Beneath the cracked and shattered soil of t... [Klicken Sie hier für weiteres]
"The castle came into view as I turned the corner and left behind me a row of untenanted cottages. It was set on the crest of a hill, three walls still standing, though the roof had long ago collapsed. A lone tower stood like a charred finger against the pale sky, and I momentarily wondered if this were the tower around whose window bats ha... [Klicken Sie hier für weiteres]
We all hold a few dark, deep secrets close to their hearts. Some of our secrets are small and would seem unimportant if they were exposed to the light of day. Others are big and could change the world. This book is about secrets that have been allowed to fester and darken in the shadows. What was hidden in Robert Monroe-Tylor's coffin? What horror left Jason Andr... [Klicken Sie hier für weiteres]
Japan is a contradictory nation of ancient traditions and modern high-tech free enterprise. Within its dark shadows and hidden places, Great Old Ones, Outer Gods, and their monstrous servitors lie in wait for the unwary. In the corporate boardrooms and political offices, secret societies carry out their sinister agendas. In hoary shrines and... [Klicken Sie hier für weiteres]
AFRICA: Long known as the Dark Continent, Africa strikes fear in the hearts of civilized Westerners for its savage tribes, fierce animals, impenetrable jungles, vast deserts, lost civilizations, slave traders, contagious diseases — and the unknown.
Africa is "dark" because it is a mystery. It is the least understood, most dangerous, poores... [Klicken Sie hier für weiteres]
LOS ANGELES IN THE 1920s was a fast-growing, fast-moving city that encompassed all that was great and all that was rotten in America. Racial, ethnic, and religious melting pots presaged what the whole country would become by the end of the century. L.A. nonetheless clung to a veneer of White Protestantism more in line with farm-belt states in the Midwest. The newly-rich built pleasure pa... [Klicken Sie hier für weiteres]
WELCOME TO THE SECRETS OF MOROCCO! This book provides players with a civil, geographical, cultural, political, and Mythos tour of Morocco during the 1920s and 1930s. Morocco will seem like another world, with its cultural differences and its customs being foreign to many Westerners of the 1920s.
The country is vast, and no... [Klicken Sie hier für weiteres]
NEW ORLEANS IN THE 1920s is a city of many faces. The gaiety of Mardi Gras is juxtaposed with the rampant corruption that earned New Orleans the nickname "The City That Care Forgot." The genteel decline of the French Quarter, the location of the city's original settlement, stands in contrast to the rich opulence of the Garden District, ... [Klicken Sie hier für weiteres]


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We had a fabulous two nights at the Alberta Guesthouse recently, whilst visiting friends. The house was lovely and very easy to get to from town. The room was spacious, very clean with all amenities and good sized en suite bathroom. The breakfast was delicious with generous portions and vegetarian option, and a good opportunity to chat and have a... More
- Also Known As:
- Alberta Guesthouse Dundee, Scotland
- Official Description (provided by the hotel):
- ... it's a friendly family house ... it's not stuffy, not minimalist and a little bit quirky - it's Albertian! :D We like laughter, football, art, music and meeting new people. Included in the price at no extra charge - breakfast (meaty, veggie or vegan, all cooked freshly - and in separate pans!), wifi access and car parking.Whether you are on your own working on Dundee and simply looking for a friendly base for your stay, enjoying a city break or touring the country, Alberta is in a perfect location ... five or ten minutes by car to the city centre, and on a main bus route ... very close to the Kingsway and therefore convenient for all routes in and out of the city ... in five minutes you can be by the beach at Broughty Ferry or out in the countryside, heading for the hills and lochs! Perfect for golfing, hillwalking, cycling or shopping :) ... more less


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Talk:Semantic Maps/Setting centre in query with format=openlayers
From Mapping on MediaWiki
Thanks for the great extension.
This is similar to last problem.
If I set "centre= foo, bar" in a query while using Openlayers as the map mapping service the map will be centred at "bar, foo". It works fine when I use GoogleMaps. See [1] for an example.
{{ #ask:[[Coordinates::+]] | ?Coordinates | format=openlayers | centre=52.83372,13.67641 <!-- centre of shown map is 13.67641, 52.83372 --> }}
- Semantic Maps (Version 0.7.6.1)
- Semantic MediaWiki (Version 1.5.6)


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Discover the World: Europe Course Descriptions
Courses offered on the DTW: Europe program cater directly to the St. John's Core Curriculum. For more information on which courses apply to your college and major we recommend meeting with your Dean or Academic Advisor. For information on course equivalences, click here.
For students who are interested in the Pharmacy programs, please visit the links below for a list of course offerings for those specific programs.
General DTW: Europe Course Offerings
ART 1775 - Art and Architecture in France An overview of painting, sculpture, and architecture in rural France and the city of Paris from Roman Gaul through the 19th Century. 3 credits.
ECO 1320 - Economics of Poverty and Income Inequality An examination of the everyday life of poverty stricken individuals. Critical analysis of the development of economic policy, economic trends and the conditions that would have to be changed if poverty is to be ended. 3 credits.
FRE 1010 - French Level I This course aims to develop basic communication skills in French. Through a progressive use of the four skills: listening, speaking, reading and writing, students develop oral and written proficiency at a limited level within the context of French culture. 3 credits.
PHI 3000C - Metaphysics Prerequisite: PHI 1000C or permission of the instructor. An examination of the central epistemological and metaphysical issues of modern philosophy. 3 credits.
THE 2810 - Religions of the WorldA critical introduction to the study of world religions. Explore the beliefs, rituals and ethical ideals of representative religious manifestations of the past and present. Characteristic traits and patterns in tribal, imperial, naturalistic, mystical and national religions. 3 credits. Rome:
ART 1795 - The City of Rome A study of the city of Rome through its art, historical periods, literary and cultural movements and physical structure. 3 credits.
ITA 1010 - Italian Level I This course aims to develop basic communication skills in Italian through listening, speaking, reading and writing. Students develop oral and written proficiency at a limited level within the context of Italian culture. 3 credits.
THE 3305 - Moral Theology of the Marketplace An exploration and analysis of moral decision-making as it applies to the world of business. 3 credits.
IB 3341 - International Business Examines the strategy of global operations and examines several basic approaches to coordinating operations located in different countries. The challenges which confront these managers are identified, as are the opportunities and tradeoffs which must be considered in addressing those challenges. 3 credits.
LAC 1000C - Language and Culture of Spain This course focuses on the study of the historical and social development of the Spanish culture and civilization. This course will also offer a brief approach to the linguistic situation and language policy in Spain and in the world." 3 credits. *Equivalent Courses: FRE 1000, ITA 1000, SPA 1000, LIN 1000, MFL 1000, CSD 1155, RCT 1155, SPE 1155, HON 2800 (If you have taken any of the above, you cannot take LAC 1000)
SPA 2030 - Spanish Level IIIPrerequisite: SPA 1020 or permission from the chair. This course reviews the basic skills learned in Spanish I and II and continues building oral and written proficiency with more intensive reading and conversation within the context of Spanish culture. 3 credits.SPA 2040- Intermediate Spanish Conversation Prerequisite: SPA 2030 or permission from the chair This course reviews the basic skills learned in Spanish I, II and III and continues building oral proficiency with more intensive conversation within the context of Hispanic culture. 3 credits PHI 2200C - Ethics Prerequisite: PHI 1000C. Human happiness and the essential means of achieving it; universal and objective morality vs. relativism and subjectivism; principles used in formulating a rational moral judgment; the functions of law and the conscience; prudence and the moral virtues as the heart of the moral life. 3 credits.THE 2500 - History of the Church A survey of church doctrines and institutions, critical moments in church history and interpretive resources useful for understanding them. 3 credits.Integrative Seminar Courses (Online)
GOV 3992 - DTW Integrative Seminar: Politics of the European Union in Paris, Rome and Seville This course aims to integrate the field experiences of the DTW students through a unifying theme, the European Union. The course gives students basic abstract tools for understanding regional integration and its impact on member states, their populations and their economies. It also offers them the possibility of taking advantage of resources available in the three cities (organizations, sites, think-tanks) to enhance their understanding of issues and challenges pertaining to international cooperation in general and to the EU relations with France, Italy and Spain in particular. 3 credits.
ART 1745 -DTW Integrative Seminar on the European Union: Arts, Architecture & Culture in Spain, France and Italy The goal of this course is to introduce students to the history and organization of the European Union and to its initiatives in the areas of arts and culture. In addition to surveying European Union Policy and Program Initiatives and European Union projects to promote ""European Identity,"" the course examines case studies of European Union initiatives in art, culture and tourism in each DTW country/city. These European Union initiatives and impacts are compared with more significant national initiatives in the area of arts, architecture, and museum-building in each country/city to explore questions of internationalism, nationalism and global identity. 3 credits.
*In addition, students are also able to take Online Learning courses while they are abroad. Please check with your dean or academic advisor for more information.


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Earthwatchers investigated how and why the meerkats of South Africa's Kalahari region cooperate in raising their young.
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Meerkats work together to hunt, guard their homes, and raise their young; Earthwatch research helped explain the impacts of these behavior patterns and their significance to other species.
Professor Tim Clutton-Brock spent more than a decade studying meerkat society in the Kuruman River Reserve in the Kalahari Desert of South Africa. The study focused on the evolution of cooperative behavior among these charismatic animals.
The meerkats in this study were accustomed to human beings, and as a result Earthwatch volunteers were able to walk with the groups as they foraged and run with them when they fought with neighboring groups, to accurately record data such as births, deaths, pregnancies, and changes in dominance status. Volunteers also documented group contributions made by individual members, such as babysitting, pup feeding, sentinel duty, and burrow renovation. Volunteers also worked with individual meerkats, which were trained to climb onto top-pan balances (using boiled egg crumbs) to be weighed three times a day.
The Kuruman River Reserve is home to the meerkats of the television show Meerkat Manor, and the series is filmed on site using one of Professor Clutton-Brock's habituated family groups. Part of the income from this has been used to improve the living conditions of families living on the reserve, including providing electricity and running water to every house and education to their children.
Data collected by Earthwatch volunteers and resident researchers helped answer questions about the costs and benefits of group living.
This long-term project enabled researchers to explore the impact of cooperative breeding on animal populations.
Kalahari meerkats care for one another's young, an unusual behavior called cooperative breeding. Researchers know little about the outcomes of cooperative breeding for species—they wonder, for example, if cooperative breeding makes it easier or more difficult for groups of animals to grow and thrive.
These researchers used meerkats as a model for investigating such questions. They recorded the growth, breeding success, and survival of all individuals in the 20 meerkat groups in the study area, and compared that information with daily records of precipitation and temperature and weekly records of plant cover and food availability. In addition, the group measured predation, the incidence of tuberculosis, rates of animals joining or leaving the study population, and the frequency of group establishment.
Meerkat appearing from burrow.
In addition to investigating the larger outcomes of cooperative breeding, the researchers explored the question of why animals like meerkats work together. Long-term data and specific individual data collected by Earthwatch volunteers and researchers helped to answer a number of questions on the costs and benefits of group living and to answer the question of why some animals live in cooperative groups.
The project was based in the Kalahari region of South Africa, near the Botswana border. The Kalahari is called a desert, but in fact it's a semiarid savanna covering 350,000 square miles (900,000 square kilometers) of southern Africa. It is home to many of Africa's most iconic animals, including giraffes, baboons, leopards, and cheetahs.
Scattered across the region are dry river beds, acacia trees, and several extensive game reserves. The meerkat populations that were studied lived mainly in the Kuruman River Reserve, along with such animals as blue wildebeest, eland, and mongoose. The birds included social weavers and the world's smallest bird of prey, the pygmy falcon.
Outside the reserve, where meerkats also live, are ranches owned by Afrikaans-speaking sheep and cattle ranchers. The closest village to the reserve is a small settlement that provides services to the farmers and their workers.
This is a summary:
Earthwatch volunteers were broken into groups and partnered with project interns. Each group worked together to establish meerkat group composition (essentially, a sort of roll-call of meerkats in a particular group); take note of any signs of pregnancy, lactation, dominance interactions, aggressive encounters, etc.; and keep a sharp lookout for injuries or signs of disease (e.g., tuberculosis lumps).
The members of each team spent six full days helping to collect data on cooperative and foraging behavior, actually walking and running with groups of meerkats as they interacted throughout the day. They also spent two or three days monitoring the distribution of plants and animals. The volunteers also participated in outreach to the community and visited the local school. Whenever possible, volunteers were offered the opportunity to take part in projects such as ongoing habitat clearance.
During their recreational days, the volunteers took unguided walks within the reserve or socialized with other volunteers and staff. Other activities included a picnic on one of the big dunes in the reserve and excursions to the Kgalagadi Transfrontier National Park and the Tswalu Kalahari Game Reserve, which are home to an extraordinary range of wildlife, including lions, cheetahs, and leopards.
Volunteer tracking meerkats.
What Do You Study? "My research focuses both on the evolution of animal breeding systems and on the way in which these affect population dynamics and selection. Specific topics we are currently working on include the evolution of cooperation and the causal mechanisms controlling it; negotiation between helpers and juveniles; sexual selection in females and males; and the evolution of aging. Members of my group work on a wide range of animals, including insects, fish, birds, and mammals. Much of my own work focuses on three long-term studies: of red deer on the Isle of Rum; of Soay sheep on St. Kilda; and of meerkats in the southern Kalahari."
Camp consists of several simple buildings erected on a large clearing in Budongo Forest. You'll stay in a single room that contains a bed, beddings, mosquito net, reading desk and a chair. All rooms are connected to solar electricity. There are three pit latrines on site which are shared by all. You'll have access to a warm shower, every evening after a long day's work. Water used at camp is harvested off the roofs or taken from the Sonso River so frugal use is necessary.
Evening meals are prepared by cooks who will prepare dishes including rice, chapati, potatoes, spaghetti, beans, beef, fish, ground nuts (peanuts), cow peas, assorted fresh vegetables and fruits, eggs. There are other local foods such as cassava, stewed bananas (locally known as matooke) and maize bread (locally known as ugali or posho). Breakfast will be western style.
Nam sollicitudin, this is a link example libero id malesuada commodo, est turpis sodales nisi, sit tincidunt felis nibh ac urna vivamus vel.
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What is the impact of climate change on the habitats and wildlife of Australia's rainforests?
Can farmers help revive Costa Rica's forests? Elusive wild mammals hold clues.
Can inventive livestock management bring balance between lions, other predators, and prey back to the Kenyan savanna?
Earthwatchers investigated how rehabilitation of mangrove forests can slow erosion and support marine life in Gazi Bay, Kenya.


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From KosherEye.com
1 frozen gefilte fish load, do not remove the paper wrapping1 onion, chopped2 tablespoons oil2 small cans tomato sauce1/2 teaspoon oregano1/2 teaspoon dill
Sauté 1 chopped onion in 2 tablespoons oil until translucent.
Add the 2 small cans of tomato sauce plus 1 can of water, oregano, and dill; mix. Add the wrapped frozen gefilte fish load and spoon some of the sauce over the loaf.
Bring to a slow boil, cover, lower the heat so that it simmers, and cook for one hour.
Cool in pot. When cool, unwrap. Can be served at room temperature but tastes better when chilled in refrigerator.
Recipes: Appetizer, Gefilte Fish, Kosher, Parve


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1 Meetup Group matches "Mystery Science Theater 3000" near Kansas City, MO
This group has been absorbed into http://www.meetup.com/KCGGGroup/ and is no longer actively scheduling events. Please head there for all your Kansas City Geek and Gaming needs!
Get an alert email when new Meetup Groups like this start near you.
You'll get advice, help finding members, and tools to make running a Meetup Group easier.


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Skeleton Twins
Two twins (Kristen Wiig and Bill Hader) escape death that leads them on a trip to sort out their lives and their own relationship in this comedy from director Craig Johnson (True Adolescents). ~ Jeremy Wheeler, Rovi
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Bad Milo!
An overworked executive befriends the pint-size demon that lives in his colon in hopes of preventing it from attacking his loved ones at will in this gruesomely fun creature feature from executive producers Jay and Mark Duplass. Duncan (Ken Marino) is already under pressure from his mother (Mary Kay Place) and wife (Gillian Jacobs) to start a family when his bullying boss starts to make life at the office a living hell. His gastrointestinal issues becoming too painful to ignore, Duncan visits a hypnotherapist (Peter Stormare), who quickly reveals the cause of his growing discomfort -- a diminutive demon that feeds on anxiety has moved into Duncan's bowels. Now every time Duncan gets stressed, the creature embarks on a bloody rampage. The more it comes out to play, however, the more difficult it becomes to control, prompting worries that it may soon attack his well-intending yet overbearing family. In order to prevent such a disaster, Duncan takes his therapist's advice and befriends the demon, even going to far as to give it a name -- Milo. The more time Duncan spends bonding with Milo, however, the more difficult it becomes to determine exactly where the creature will focus its wrath next. Stephen Root co-stars in a film from writer/director Jacob Vaughan. ~ Jason Buchanan, Rovi
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The Do-Deca-Pentathlon
From Jay and Mark Duplass, the writer/directors of the Sundance hits "The Puffy Chair," "Cyrus" and the upcoming "Jeff Who Lives at Home" comes "The Do-Deca-Pentathalon" - the story of two grown brothers who secretly compete in a homemade Olympics during a family reunion. When their fierce and disruptive competition is uncovered, the brothers must choose between their passion for beating the hell out of each other and the greater good of the family.
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Jeff, Who Lives at Home
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Directing brothers Jay and Mark Duplass examine fate and family in the comedy Jeff, Who Lives at Home, starring Jason Segel as the title character, a slacker who still lives with his mother. He spends the vast majority of his time smoking pot and explaining how he's waiting to understand his own fate, using the film Signs as the model for how he takes in the world. His brother Pat (Ed Helms) is a salesman in a mid-life crisis having purchased a sweet new sports car over the objections of his wife (Judy Greer). After Jeff answers the phone and a voice demands to speak to "Kevin," the stoner believes this is the sign he's been waiting for. During the course of the day, Jeff and Pat will confront their issues with each other, while their long-suffering mother (Susan Sarandon) may find love for the first time since the death of her husband. The film played at the 2011 Toronto International Film Festival. ~ Perry Seibert, Rovi
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Black Rock
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Three women on a camping trip find their fireside bonding interrupted by a group of psychotic veterans in this survival thriller from writer Mark Duplass and his wife, first-time director Katie Aselton (who also stars). As young girls, Sarah (Kate Bosworth), Lou (Lake Bell), and Abby (director Aselton) used to spend much of their spare time on a secluded island just off the coast of Maine. Years later, Lou and Abby have grown estranged after the former slept with the latter's boyfriend, and Sarah hopes to see them reconnect by taking a nostalgic trip to their favorite childhood haunt. As dusk falls, the ladies encounter an old classmate named Henry (Will Bouvier) trekking through the woods with his friends Derek (Jay Paulson) and Alex (Anslem Richardson). Armed with rifles, the men reveal they are on a hunting trip after returning from their tours of duty in the Middle East. Later, as the two groups gather around a fire for dinner, the booze begins to flow, and Abby's inhibitions fall away. Before long, Abby and Henry are all over each other. But the situation turns critical when Henry gets too rough, and Abby accidentally kills him while attempting to break free. Upon learning that their brother in arms is dead, Derek and Alex vow that the women won't get out of the woods alive, setting the stage for a bloody life-or-death struggle between the battle-hardened soldiers, and the terrified female trio. ~ Jason Buchanan, Rovi
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Safety Not Guaranteed
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A personal ad placed for a time-travel partner prompts an investigation involving three magazine reporters in this quirky comedy produced by Mark and Jay Duplass (Jeff, Who Lives at Home) and starring Aubrey Plaza (Parks and Recreation). Kenneth is a self-proclaimed time traveler who doesn't want to take his next journey alone. Intrigued by Kenneth's cryptic ad, a local newspaper editor dispatches cynical reporter Darius (Plaza) and a pair of other employees to get the scoop. Upon meeting Kenneth, Darius see past his peculiar front and recognizes the lonely soul inside. As genuine as Kenneth may be, however, his questionable sanity leaves Darius uncertain of how to proceed with her story. ~ Jason Buchanan, Rovi
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Aubrey Plaza
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Directed by mumblecore stalwarts Jay and Mark Duplass, Cyrus stars John C. Reilly as John, a middle-aged lonely divorced guy who, as the film opens, gets dragged to a party by his remarried ex-wife (Catherine Keener) -- who remains his best friend. After a few clumsy, drunken passes at a variety of women, John encounters Molly (Marisa Tomei), an attractive single-mom who finds John's social awkwardness appealing. They hit it off, and quickly begin a tender new relationship. Problems soon arise in the form of Cyrus (Jonah Hill), Molly's twentysomething son, who has an off-puttingly close relationship to his mom. Soon the jealous Cyrus sets about trying to break them up, and John must figure out how to deal with this unhinged and unexpected rival. ~ Perry Seibert, Rovi
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Lovers of Hate
A man looks for a way to get even with the sibling who has stolen away the woman he loves in this independent comedy drama from writer and director Bryan Poyser. Paul (Alex Karpovsky) and Rudy (Chris Doubek) are brothers who are also both writers, though their careers are on opposite ends of the spectrum of success; Paul has authored a series of fantasy novels for kids that have made him a very wealthy man, while Rudy's bitter and more personal work makes no inroads into the marketplace. Rudy is envious of his brother's good fortune, in part because he helped him come up with the characters for his stories when they were children. Rudy does have one thing that Paul wants, however -- Rudy's wife, Diana (Heather Kafka), who is disenchanted with her husband's dour attitude and money troubles and wants a divorce. After Diana finally kicks Rudy out of their home, he's reduced to living out of his car until Paul takes pity on him and pays for an extended stay at a hotel. What Rudy doesn't know is that Paul has given him a place to stay so he can invite Diana on a getaway to a luxury ski resort in Utah. Once Rudy catches on that Paul is seducing his ex-wife, Rudy makes his way to Utah and sneaks into their chalet, following their movements as he plots his revenge. Lovers of Hate received its world premiere at the 2010 Sundance Film Festival -- fitting, since Poyser shot the Utah sequences in Park City while attending the Sundance Festival in 2009 (using the bungalow where he and a number of other Austin, TX filmmakers were staying as the set for Paul and Diana's love nest). ~ Mark Deming, Rovi
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Chris Doubek
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Nights and Weekends
Two people who fall in love while separated by 800 miles find it's hard to stay friends while living in the same city in this low-key independent drama. James (Joe Swanberg) and Mattie (Greta Gerwig) are in love and trying to make their relationship work. But James lives and works in Chicago, while Mattie calls New York home, and though they try to visit one another as often as they can, their infrequent weekends together are punctuated by telephone calls, e-mails, on-line chatting, and sending digital pictures back and forth. As much as Mattie cares for James, in time the space between them is too much to deal with and they break up. Twelve months later, James' career as a video-game designer is taking off, and a new project necessitates a move to New York City; while they're no longer lovers, he tries to reconnect with Mattie, though his recent success has added a new and uncomfortable element to their relationship. Joe Swanberg and Greta Gerwig wrote, directed, and produced Nights and Weekends as well as playing the two leads; the film received its world premiere at the 2008 South by Southwest Film Festival. ~ Mark Deming, Rovi
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The Puffy Chair filmmaking duo Jay and Mark Duplass return to the realm of cinema with this tale of a man, a bag, and the strangeness that occurs when the two independently inconsequential factors come together. ~ Jason Buchanan, Rovi
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The Intervention
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The Puffy Chair
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Dejected by his failure to achieve fame as a New York City indie-rocker and unable to figure out just when it was that his life took a sharp turn for the worse, a small-town boy who had once harbored big dreams for the future sets out on a cross-country adventure to give his father a birthday the old man will never forget in director Jay Duplass' nostalgic road trip comedy. Josh (Mark Duplass) may not have found the success he was hoping for in the big city, but he's determined not to go back home empty-handed. When an eBay browsing session leads Josh to a vintage Lazy Boy recliner just like the one that used to grace his childhood living room, the loving son opts to purchase the purple relic and deliver it to his father as a surprise birthday gift. Josh's simple plan is suddenly complicated by the appearance of his emotionally demanding girlfriend, Emily (Kathryn Aselton), and his granola-munching brother, Rhett (Rhett Wilkins) -- who both insist on joining him on his homeward-bound mission. While the hapless would-be rocker sets out with them on a mission to deliver a piece of his childhood to his father back home, he might also learn a thing or two about himself and his relationships in the process. ~ Jason Buchanan, Rovi
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This Is John
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Sweet Thing
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Emerging artist Sean Fields (Jeremy Fox) is haunted by the hidden brutality of his upbringing at the hands of his abusive stepfather Ray, a powerful Texas judge (Ev Lunning Jr.). This mental state is reflected in his sexually explicit and controversial paintings. On the brink of being discovered (he's been tapped for a major exhibition), Sean falls in love with the sexy and wild Hannah (Amalia Stifter), whose life is complicated by a relationship with crude and protective redneck Davie (Stephen Bruton). Davie seems to know something about Hannah that Hannah would rather Sean did not discover. As it happens, Judge Fields has hired Hannah, through lowlife intermediaries, to keep Sean from painting; the judge thinks Sean's success will disgrace his name and prevent him from winning a seat in Congress. It all comes to a horribly violent end.
~ Buzz McClain, Rovi
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Tag Archives: Louis Castle
Tue, Jul 13, 2010 | 18:08 BST
GameStop: "We don't like being in the used games business"
US retailer GameStop has admitted that it "doesn't like" being in the second-hand games market.
Wed, Mar 03, 2010 | 13:05 GMT
First Develop Brighton keynotes announced
Westwood founder Louis Castle is to keynote Develop in Brighton this year.
Thu, Jul 16, 2009 | 19:04 BST
Louis Castle departs EA's Westwood Studios for InstantAction
Louis Castle, co-founder of EA's Westwood Studios has left the firm for free-to-play games company InstantAction where he will act as CEO.
InstantAction specializes in third-party 3D browser-based games funded through advertising and micro-transactions.
Castle, who founded Westwood with Brett Sperry in 1985, became general manager of EA's Blueprint Studios after Westwood was acquired by the publisher in 1998. It's greatest success came from Command & Conquer series.
Via GI.biz, IndustryGamers.


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by Phil Nickinson
Aug 09, 2011
Looks like Sprint's got quite the mouthful coming to its stable in the coming months, according to a leak received by Engadget. The U.S. carrier's version (previously codenamed "Within") of...
by Bla1ze
Jun 15, 2011
We've seen blurry images and even a leaked ROM for the upcoming HTC Kingdom but this time around -- things just got a whole lot more real. Right now, the FCC is checking out a device that's labeled as...
by Jerry Hildenbrand
May 05, 2011
The Internet's all abuzz over a render and a leaked ROM for the HTC Kingdom, but what is it? A peek through the leaked files tell us it has a 1.2 GHz Qualcomm MSM7630 CPU, 768 MB of RAM, a four-...
by Phil Nickinson
May 03, 2011
Remember how the leaked "HTC Kingdom" pictures looked a heck of a lot like the EVO 3D we got our hands all over at CTIA? There's good reason for that, it appears, as a leaked Kingd...
by Alex Dobie
Apr 28, 2011
Here's yet another leak from Chinese blog 911Sniper - a single, super-blurry image of a device purported to be the 'HTC Kingdom'. No real hardware details are offered, but 911Sniper does claim...


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Using Personal Care Market Trends to Add Value in Food and Drinks
Report description
The personal care industry was worth over $460bn in 2010. But perhaps of greater interest to food and drinks manufacturers is the industry's ability to increase its value on an ongoing basis. This report examines crossover trends in ingredients, packaging and professional design to outline opportunities for food and drinks products to command a premium positioning.
Be aware of the personal care trends that are most relevant for the food and drink sector and understand how these can add value and increase margins.
- Understand how rare and functional ingredients are used within new personal care products and gain insight into future opportunity areas.
- Gain insight into packaging developments within the personal care sector and which elements of quality design can be applied to food products.
- Understand how collaborations with artistic talents can be used to add value to food and drink products.
- Identify future product crossovers between the food and drink and personal care sectors.
In a recent evaluation of new product claims/tags, 'upscale' was the most commonly occurring for new personal care products, whereas it is was the 13th most common for new food and drink products. The personal care industry is consistently employing methods to justify a premium positioning for its products.
The higher growth rate in the market value of the functional food market compared demonstrates the potential of creating products that offer extra benefits to consumers. Those botanical ingredients (fruits and plants) that are 'rare' and have proven functionality through supporting clinical data are of special interest to the food and drink sector
The use of master developers in the personal care sector is more pervasive then the food industry. However, although there also appear to be more tie-ins and joint collaborations with designers and artists in the personal care sector, there is room for increased use of other artistic professionals within food and drink design and promotion.
- What are the key trends within the personal care market that offer opportunities to the food and drink sector?
- Which rare ingredients, used in what type of applications, are likely to provide opportunities for the food and drink sector and why?
- What elements of quality and sensual packaging are prevalent in personal care and what do these look like when translated to food and drink?
- How can art and food can be combined to create interesting products and promotions?
- What are the future product crossovers between the personal care and food and drinks industries?
Table of contents
•DisclaimerEXECUTIVE SUMMARY
•'Rare' and functional ingredients
•High quality and sensual packaging
•Master developers
•Learning from personal care successes
Important similarities and differences
•Personal care vs. food and drink trends and innovations
Food and drink trends and innovations
Personal care trends and innovations
Shared and cross-over trends and innovations
•Personal care trends offering opportunities to food and drink
•Report focus, methodology, and structure
Report structure
'Rare' and functional ingredients
•Drivers of the 'rare' ingredient trend
•Use of 'rare' ingredients in personal care
'Rare' ingredients derived from animal products
Precious metals and stones
Exotic plant and fruit extracts
•Use of 'rare' ingredients in food and drink
'Rare' ingredients for sensory uniqueness
Exotic and functional plants and fruits
•Market opportunities
Ingredients and categories
•Potential barriers
Quality and sensual packaging
•Drivers of the quality packaging trend
•Personal care emotive packaging design
•'High quality' packaging in the food and drink sector
Form and design
Material effects, color, and printing quality
•Market opportunities
Categories and consumers to target
•Potential barriers
Master developers
•Drivers of the 'Master Developer' trend
•Heritage, celebrity and technical expertise in personal care
•Novel expressions of artistry in personal care
•Food and drink and celebrity chefs
•Art and food and drink
Food, art, and science
Art and packaging
•Market opportunities
Branding and complementary product lines
Potential applications
•Potential barriers
•The top ten personal care trends for food and drink
•Key strategic opportunities for both sectors
•From crossover trends to crossover products
Rare ingredients
Quality and sensual packaging
Master developers
•Table: Market value by market/industry ($bn), 2009–2015
•Table: Top 25 claims/tags found on personal care and food and drink launches, 2010–2011
•Table: Predicted global market value growth of selected categories and of the functional segments within them, 2009–2015
•Figure: Building blocks of success in the personal care sector
•Figure: Innovative new products offered in tube and box format
•Figure: Recent personal care and food and drink innovations and trends
•Figure: Recent 'healthier' launches of foods typically considered 'less healthy'
•Figure: Personal Care Crossover Trends report series – featured personal care trends offering opportunities for food and drink
•Figure: Drivers of the 'rare' ingredient trend
•Figure: New personal care products based on a snake venom concept
•Figure: New personal care products containing gold and silver
•Figure: Floralis Diamond Magic Products with diamond dust
•Figure: The Nivea Pure and Natural Range
•Figure: Cleanlogic Bath & Body Care Soap + Sponge with Nopal Extracts
•Figure: Kiehl's Youth Regenerating Cream with Rare Resurrection Flower
•Figure: Faberlic Collection Polynesie Warm Melting Hair Mask featuring noni berry extract
•Figure: New food and drink products containing royal jelly
•Figure: New foods with 'rare' ingredients and unique sensory properties
•Figure: Navitas Naturals Rainforest Super-fruit Certified Organic Camu Powder
•Figure: Opportunities and applications of the 'rare' ingredient trend
•Figure: Drivers of the quality and sensual packaging trend
•Figure: Curved shapes and emotive packaging for perfume and tea
•Figure: MAC Street Art Eye Shadow
•Figure: Makeup and fragrances with attractive packaging retailing for under £35
•Figure: Shape and color in personal hygiene and OTC healthcare packaging
•Figure: Stylish and modern wine packaging
•Figure: Elusive 0210
•Figure: Aqua Carpatica - Still Water
•Figure: Products with matt packaging
•Figure: Suntory Gokuri – Mandardin Orange Juice Drink
•Figure: Examples from the Rexam beverage can innovation showcase
•Figure: Opportunities and applications of the quality and sensual packaging trend
•Figure: Drivers of the Master Developer trend
•Figure: New personal care products designed with technical expertise
•Figure: Joop! - Eau De Toilette for Men - Sexy In Pink
•Figure: Six Scents Series Three No. 1 - Beau Bow by Alexis Mabille & Rodrigo Flores-Roux
•Figure: The five chefs each developing a meal for the Morrisons 'M Kitchen' Range
•Figure: New products from around the world linked with celebrity chefs
•Figure: Heston From Waitrose Puff Pastry Mince Pies with Pine Sugar Dusting
•Figure: New wine and spirits with packaging/labeling designed by artists
•Figure: New confectionery products with packaging designed by famous artists
•Figure: Opportunities and applications of the master developer trend
•Figure: Categorizing opportunities personal care trends offer food and drink
•Figure: Top ten personal care trends offering opportunities for food and drink
•Figure: Sunlover Beauty Drink
Related research categories
By sector: Trends, General drinks
The just-drinks office is currently: Open
Office opening hours
Mon-Thursdays 9:00am-5:30pm
Fridays 9:00am-4:30pm
The office is closed during weekends.
Current time at just-drinks headquarters: 9:13am (Thursday, 12 December 2013)
Do you need help finding the right report? Speak to a member of our research team online.
Why not check our FAQ section? Your question may have been answered already!


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Celine Spring 2013 | Runway
Céline Spring 2013
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by Christina Perez
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I had never heard of this "first capitol of Texas" until this recent trip. The owners, Flem & Sheryl, live next door and you'll never meet a more interesting couple. Flem is president of the local historical foundation which maintains this incredible street of historic homes that was the most bustling trading community at the time of the Texas War... More
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West Columbia
Ranked #1 of 1 B&Bs / Inns in West Columbia


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Bond Dealers See No End to Fed's QE in 2013 (Video)
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text: We love giving new up and coming restaurants our business. The first time we ate Smashbrger, it was here. We've been back several times since it's fast, tastes home cooked! The last time we went, our smash fries (the ones with rosemary) were SWIMMING in four tablespoons of oil!!! YUCK... yes, I spooned out the oil and manager came by... More


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6 Most Popular and Free Remote Desktop Sharing Tools
Tweet Many times in your daily lives, you go by instances of helping people (friends, parents, relatives etc.) in remote locations who are not tech savvy. Whenever you are in such situations where someone need help of your computer knowledge … Continue reading


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70 Reviews
For full terms and conditions please see our Delivery & Returns policy
28/11/2011 17:00:38
Great product, i made this purchase as this was the type of jacket i was looking for and a great price. I was looking for a jacket without the logo on the breast so i can have it personalised for work wear. Some of the jackets did have the logo on the breast (i was told these were a newer range) so im still hunting for other sizes that i need as otherwise the jacket is perfect.
18/07/2013 10:02:38
I saw this product, tried it on and liked it, although I wasn't sure if to buy it or not.... Then I went back and bough it. It is light, waterproof and windproof, it has internal pockets which are great for putting small things like a mobile, keys or money that you wouldn't want to leave exposed when going on holiday. The cut is also great, it suits me perfectly :)
23/01/2012 19:32:13
Just what I was looking for so I can keep warm while cycling in all weathers. I had one before buying this one but it got stolen and I knew MW would have just what I was looking for. Lovely deep pockets with zip so keeps everything in and not to fall out while I am cycling. Warm up to the neck and I love the new cuffs on the sleeves.Keeps me dry and warm.
16/10/2013 09:57:53
I am between a size 10-12. I found that the size 10 was a bit too snug but the sleeve length was perfect. However the size 12 was a bit roomier but I had to fold back the sleeves to wear it and it didn't fit too well on me. So I had to return the product which was a shame as the overall quality of the product felt good.
09/10/2012 16:54:14
I am very pleased with this jacket. It is warm, yet breathable, and also very comfortable. So far I have worn it in drizzle and the fabric seems to repel water well. My only criticism is that (as I find with all Mountain Warehouse clothing) the sleeves are a little long.
21/11/2011 20:21:46
Would be nice if there were a wider range of dark colours although there were a lot of lighter colours. However, to wear around horses and outdoors those colours would get dirty very quickly. Especially keen to get a dark blue.
01/07/2012 18:05:13
The size 12 is a little snug with a fleece under, and the size 14 was too roomy and looked baggy even over clothes. Bought as i liked the design and will probably only use over a t shirt or a light shirt.
11/06/2012 14:10:43
Delighted to find this jacket on my trip to a retail park as I had been unable to get it locally. Colour described as 'purple' but more like a cerise & exactly what I wanted.
29/09/2012 20:10:57
Perfect lightweight jacket for this time of year when something waterproof is needed but it's still too warm for big winter coats. Also it looks smart enough to wear for work.
03/09/2013 18:44:46
a great buy for my wife who will get good use from this item, I was looking for a good value golf waterproof suit and would like to know when and if you have any in stock
25/07/2013 21:19:55
Love the colour of this jacket and feels soft and thick. Only gripe is the sleeves are slightly too long but they have adjustable velcro to keep them tight at the cuffs.
21/10/2013 11:26:21
useful for under my Mountain Warehouse jackets as the shell material does not drag like ordinary fleeces when putting my arms in and out of my outer coat.
07/03/2012 20:46:58
i wanted this jacket, as my partner had one as a present. it has worn well and washed well. It is a smart jacket and can be worn casual.
14/10/2013 13:37:07
Bought these as a layer for hiking in Scotland. Feel really good quality and the fit is perfect. My husband bought the mans one as well.
17/08/2013 08:50:20
Bought it as an extra layer for a trip. Good shape, light weight. a little wide in the sleaves. Hopefully will cover low temperatures.
02/07/2012 14:54:17
I have looked all over for a soft shell like this. Exactly the colour I was looking for and the quality is excellent. Good price too.
09/10/2013 21:29:33
Jacket is warm, soft and a great colour. Good to use as an extra layer in the winter with a waterproof jacket on top.
20/09/2013 20:33:41
Worn on a short break to Scotland. Kept me warm, was comfortable and smart looking. I am sure I will wear a lot.
20/09/2013 20:34:20
07/08/2012 15:25:17
Good price, well-made. Adjustable velcro on the bottom of the sleeves good idea-keeps sleeves ideal length.


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Option 1 | Including every family: getting parents on board in primary schools
Option 2 | Tackling homophobic language in secondary schools
Option 3 | Protecting young people: improving mental health and wellbeing
Option 4 | Success through student-led initiatives
Option 5 | Enhancing the student experience in further and higher education
Option 6 | From good to great: local authorities leading the way
Option 1| Out in the classroom: supporting gay staff
Option 3 | Faith schools: are they really part of the problem?
Option 4 | Sex and relationships: informing and safeguarding young people
Option 6| Sexual orientation and gender: how should we address these issues in the curriculum?
Followed by a drinks reception supported by the Times Educational Supplement.
Friday 5 July 2013
Barbican Centre
London EC2Y


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Cherokee County Fire and Emergency Services responded at about 11:20 a.m. to the animal rescue call in the 100 block of Hancock Mountain Trail in the Salacoa community of northwestern Cherokee County.
Firefighters arrived on the scene and were directed to the location of a large horse that was lying on its side underneath a small old bridge, according to Tim Cavender, spokesman for the Cherokee County fire department.
The horse appeared to be in distress and it was unknown as to how long it had been underneath the bridge, Cavender said.
Cherokee County Special Operations Chief Darrell Mitchell made a request to contact the Milton Animal Rescue Team and for a wrecker service to help lift the animal back on its feet.
The firefighters on the scene, along with Cherokee Animal Control officers and Milton's Animal Rescue Team were able to drag the horse from underneath the bridge, Cavender said.
The horse was later positioned so members of the rescue team could pull her up so she could stand on all four legs.
The first attempt was unsuccessful as the horse collapsed and began to lie on its side again, Cavender said.
"A second attempt was made and the horse was able to stand," he said. "For a brief moment, it appeared that the horse was going to fall on its side again, but a tree helped to brace the horse and it continued to remain standing." The horse was later led out of the area and taken to a nearby pasture, Cavender said.


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MN: Amtrak Train Hits Semi; Truck Driver Killed, Several on Train Hurt
An Amtrak train struck a semitrailer truck that failed to stop at a crossing in central Minnesota, leaving the big rig's driver dead and several on the passenger train injured, authorities said.
The collision involving the eastbound Empire Builder occurred Friday afternoon at the rail crossing at 317th Avenue in Fawn Lake Township, according to the Todd County Sheriff's Office.
Killed was semi driver Donald R. Hedlund Sr., 57, of Bemidji, the Sheriff's Office said. Hedlund was driving...
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