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im not sure that really answers my question ebura,
i find it hard to conceive how any distinction could be make without a sample of the very earliest incarnation of both.
I am not talking here of interstellar transfer...i agree entirely that is extremely unlikely, which is why my personal opinion is that study of exo planets is the best way open to us to answer that question. That or we just get really lucky by stumbling across phosphorus based life or some such thing.

subset: commoncrawl


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Pat Monahan
Pat Monahan
Last of Seven
Original Release Date: September 18, 2007
Track Listing
1. Last of Seven
2. Her Eyes
3. Two Ways to Say Goodbye
4. Someday
5. Cowboys and Indians
6. Ooh My My
7. Thinkin Bout You
8. Raise Your Hands
9. Always Midnight
10. Great Escape
11. Ripple in the Water
12. Girlfriend
13. Pirate on the Run
14. Shine
Graham Nash: Vocals
Richie Sambora: Guitar (Acoustic)
Alexandra Brown: Vocals (Background)
Bridgette Bryant: Vocals (Background)
Vinnie Colaiuta: Percussion, Drums
Abraham Laboriel, Sr.: Drums
Jay Landers: A&R
Patrick Leonard: Piano, Composer, Keyboards, Producer, Drum Programming
Bob Ludwig: Mastering
Kristle Murden: Vocals (Background)
Carolyn Perry: Vocals (Background)
Darlene Perry: Vocals (Background)
Lyle Workman: Guitar (Acoustic), Composer, Guitar (Electric)
Sean Hurley: Bass
Brandon Bush: Composer
Lars Fox: Digital Editing
John Shanks: Guitar (Acoustic), Composer, Guitar (Electric), Producer
Frank Harkins: Art Direction
Sheryl Nields: Photography
Evan Lamberg: A&R
Pat Monahan: Percussion, Composer, Vocals
Jimmy Stafford: Guitar (Acoustic), Guitar (Electric)
David E. Williams: Guitar (Electric)
Billy Bush: Guitar (Electric), Engineer, Mixing
Luis Maldonado: Guitar (Electric)
Caroline Campbell: Violin
Dana Glover: Vocals (Background)
James Freebarin-Smith: Cello
Jerry Becker: Guitar (Acoustic), Guitar (Electric)
Seth Waldmann: Engineer
James Bourne: Composer
Miguel Atwood-Ferguson: Viola
Brandi Carlile: Vocals
Neel Hammond: Violin
Danielle Ondarza: French Horn
Tom Syrowski: Engineer
Steve Dress: String Bass
Aaron Sterling: Percussion, Drums
Matt Serrecchio: Engineer
Jesse E. String: Cello, Engineer, Digital Editing
Brian Macleod: Percussion, Drums


text:
Product Features:
- Fully covered under a 5 year warranty - 5 times the industry standard
- Quick, quiet flushing - American Standard toilets are notoriously efficient and hushed
- Industry-leading flushing system out-performs older toilets while using less than 1/2 the water
- Tank flushing components specially engineered to withstand chemically-treated urban water
- EverClean porcelain surface is extremely easy to keep clean, including inside the bowl
- PowerWash flushing completely clears the bowl, including under the bowl rim
- Sanitary bar on bowl prevents liquids from traveling under the tank
- Round bowl shape - space saving and more economical than elongated bowls
- Two-piece toilet - less cumbersome than one-piece designs to lift, carry, and install
- Chair-height bowl - easier to sit and stand; appropriate for adults and the elderly
- Left mounted tank lever
- Perfected porcelain casting process and adjustable tank anchors eliminate "tank wobbles"
- Straight-forward installation instructions are included with each toilet
- 100% factory flush tested - guaranteed to perform
- Toilet seat is not included - when adding to cart, options that fit this toilet will be presented
- Wax ring kit (for installation) is not included - when adding to cart, this inexpensive item will be presented
Cadet 3 Flushing:
- 3" flush valve – The flush starts with a flushing system that employs a 3" valve opening, allowing water to enter the bowl at a much faster rate than the industry standard 2" flush valve. Controlled by a flapper that is engineered to be chemical-resistant, the Cadet flushing valve system is highly regarded for its durability.
- 360 degree cleaning – Water entering the bowl does so in a sweeping 360-degree motion. This is designed to help completely clear the bowl, even while using less water.
- Powerful siphoning water jet – A perfectly positioned water jet captures the circular flow of water for optimal performance with minimal energy loss (water doesn't hit a flat spot and slow down). As waste and water exit, they are siphoned into the trapway for an unmatched push/pull one-two punch.
- 2-1/8" fully glazed trapway – Waste and water exit the toilet through a trapway that is fully glazed, which seals it and provides for a smooth surface that waste can in no way cling to. The 2-1/8" diameter chute, while slightly narrower than the American Standard Champion flushing system's 2-3/8" trapway, can still flush up to 150 feet of toilet paper without clogging. Not that you'll ever use that much.
Other Technologies / Benefits:
- Everclean Surface – Using the antimicrobial properties of silver (the precious metal), Everclean Surfaces inhibit the growth of bacteria, mold, and mildew. The super smooth, baked-in, mirror-like surface not only eliminates unsightly rings, but also helps repel toilet messes.
- PowerWash Rim – During each flush, a measured amount of water travels within an inner-rim channel to be evenly dispersed throughout the bowl. PowerWash rims are surprisingly good at completely clearing out the bowl after each use.
- Right Height – Right Height bowls lift the sitting-height an additional 1.5 inches off the ground for a more comfortable seated position that is easier to get in and out of. This feature is particularly well liked by men, taller women, and the elderly.
Product Specifications:
- Overall Height: 30-3/8" (measured from the bottom of the base to the highest point on the toilet)
- Overall Length: 26-1/4" (measured from the back of the tank to the front of the rim)
- Overall Width: 18-1/8" (measured from the furthest point on the left to the furthest on the right)
- Bowl Height: 16-1/2" (measured from the bottom of the base to the rim)
- Rough In: 10" (measured from wall behind toilet to center of waste outlet hole in floor)
- Flush Valve Size: 3" (diameter of the inlet for water entering bowl from tank)
- Trapway Size: 2-1/8" (diameter of the outlet for water/waste exiting the bowl)
- Flow Rate: 1.28 GPF (gallons-per-flush)
- Water Area: 9" X 8" (inner rim dimensions length X width)
- Water Depth (From Rim): 6-1/2"
- Tank Trip Lever Placement: Left
- 215BB.104 - This model
- 215BA.105 - This model with right-hand trip lever
About American Standard:
An American brand with over 140 years of innovations, American Standard is defined by experience, intelligence, and indelible influence. As the patriarch for nearly every key product category for the kitchen and bath, their offering shows a level of thoughtfulness and sophistication that could only be attributed to a company with a legacy as rich as that of American Standard. Today, professional plumbers and contemporary DIY home owners continue to turn to American Standard because they appreciate this legacy and know they can trust the innovations behind each product. It is for this reason that American Standard is so widely used within residential and commercial projects in both the United States and abroad - their products truly deliver, just as they have for generations.
Additional American Standard Links
- View Manufacturer Warranty
- Shop All American Standard Products
- Shop All American Standard Cadet Pro Collection Products
Our SKU: American Standard 215BB.104
This product is listed under the following manufacturer number(s):
- American Standard 215BB.104.021*
Bone - American Standard 215BB.104.222*
Linen - American Standard 215BB.104.020
*Denotes a finish or option that has been discontinued
Product Specifications
Specification Sheet | |
Specification Sheet | |
ADA | Yes |
Bowl Height | 16.5 |
Bowl Shape | Round |
Comfort Height | Yes |
Configuration | Two Piece |
Depth | 26.25 |
EverClean | Yes |
Flowise | Yes |
Flush Technology | Cadet |
Flush Type | Gravity Flush |
Flush Valve Size | 3 |
Gallons Per Flush | 1.28 |
Glazed Trapway | Yes |
Height | 30.375 |
Installation Available | Yes |
Installation Type | Floor Mounted |
Insulated Tank | No |
Manufacturer Warranty | 5 Year |
Material | Vitreous China |
PowerWash | Yes |
Product Class | Residential |
Rough In | 10 |
Seat Included | No |
Theme | Traditional |
Trapway | 2.125 |
Trip Lever Placement | Left |
Water Area | 9 x 8 |
Water Efficient | Yes |
WaterSense Certified | Yes |
Width | 18.12 |


text:
03-24-12 – Miami, FL>Orlando, FL – Premier Electronica and live performance bands seeks
quality DJ/Scratcher, Bass player & Guitarist. We have
recently made some changes and we'll be releasing a
CD in April.
We are NOT, repeat, NOT a cover band.
Not interested in "hired guns" or "copycats." This is
a professional endeavor with quality management and
years of the music biz behind us.
Please send a sample of your work in either MP3 format
or a .wav file format. We'll be happy to send you some
samples back as well.
If you're a musician in a genre that is very much different
than ours, it doesn't make sense to respond. We're looking
at the long term, not just someone to fill the position for a
few shows.
We are all multi-instrumental, work as a democracy and
spend a lot of time and money developing our production
value for live shows.
If you love melodic stylings within the electronic genre,
marketable songs and an awesome stage show, then you
might want to contact us.
We're not interested in gigs at bars, hang-outs or the like,
our agreement is for 40 to 50 minute shows opening for national
acts on the South East circuit.
Please put your city and instrument in the subject line so
that we know it's a real response.
— Submit Yourself To This Role Now: 1
Click Here To Apply To This Casting Call


text:
Article Last Updated: Monday, January 21, 2013 4:47pm
Sam Green/Cortez Journal
Noah Busing leads Moose across their snow-covered pasture along Road N. Busing works with the steer everyday as part of his 4-H project for this summer's Montezuma County Fair.
By By Andrew GullifordFor The Journal
By By Gabi Morey
People are encouraged to submit announcements about upcoming events for the Community Calendar. Send announcements to firstname.lastname@example.com. Items submitted less than two weeks in advance will be less likely to be published.Saturday, Dec. 21Santa Claus is Coming to Town, he will be arriving Dec. 21, high noon until 1 p.m. at the corner of Market & Main. Santa will be...


text:
Published January 25, 2013
Newly-retired VOA video journalist Zulima Palacio tells On Assignment's Alex Villarreal about her more unusual underwater reporting adventures. She even got married under the sea. (No kidding!)
"On Assignment" is a weekly behind-the-scenes look at the VOA reporters and producers reporting the news from around the world.
Broadcast every Friday, On Assignment showcases the best of VOA reporting across the globe, giving front-line journalists the chance to share their experiences from the field, including some of the most challenging and dangerous trouble spots in the world. Each week, hosts Imran Siddiqui and Alex Villarreal give viewers a backstage pass to meet our reporters in the field and hear the stories behind the headlines.
On Assignment This Week:
How To Watch Us:
Watch Our Latest Show: Windows Media | MP4
Watch Us
Follow Us On


text:
Posted 29 August 2006
Return to Discussion Text
Participants: John Wesson Ashford (Wes), Bruce Teter, Kiminobu Sugaya, Suzanne Tyas, Keith Crutcher, Angele Parent, Bill Klein, Jacob Raber, Marsel Mesulam, Gabrielle Strobel, Alexei Koudinov, Pascale Lacor, Abraham Fisher.
Note: The transcript has been edited for clarity and accuracy.
Keith Crutcher: Hi Bruce!
Bruce Teter: Hi! Who else is here?
Kiminobu Sugaya: I am at the University of Illinois at Chicago, doing stem cell studies. Of course, I am interested in AD research
Suzanne Tyas: Hi, all. I'm an epidemiologist at the University of Kentucky. My research focuses on risk factors for Alzheimer's disease.
Angele Parent:
Bill Klein: Hi - I'm trying to eat sushi and type at the same time (beyond my skill level!)
Keith Crutcher: It would be interesting to have a discussion on the potential of stem cells for AD. Almost every news item on that story lists AD as a target.
Kiminobu Sugaya: I just came back from the Springfield/Geneva AD meeting in Switzerland. I talked about our stem cell study.
Keith Crutcher: Would the goal be to replace specific cell types or hope that cells will differentiate as they are needed?
Bruce Teter: Kiminobu - for stem cell target, what is "needed" - growth factors, neurotransmitters, etc?
Kiminobu Sugaya: Although some people were convinced by my presentation, others said we will never be able to replace neurons degenerating in AD brain.
Kiminobu Sugaya: Because, they said in AD, long cholinergic projection neurons cannot be replaced. I think it can be done. It's early days.
Keith Crutcher: There is precedence for transplantation of long-projecting neurons, namely dopamine neurons a la Anders Bjorklund's group.
Kiminobu Sugaya: Yes, that is why I said it can be done. On top of that, when we transplant the cells they migrate more than 1 cm in two weeks.
Jacob Raber: Is it not a general observation that the new cells may not easily obtain a neuronal phenotype?
Kiminobu Sugaya: In our case we saw a very nice neuronal morphology everywhere.
Bruce Teter: yes, replacing projecting neurons would be nearly ideal, but that hasn't stopped L-dopa treatment in PD or cholinesterase treatment in AD--seems like local effects can be somewhat therapeutic.
Marsel Mesulam:
Keith Crutcher: Looks like we have a moderator....Hi Gabrielle!
Gabrielle: Hi Keith, hello and welcome to you all. I am Gabrielle Strobel, managing editor of the Alzheimer Research Forum.
Wes: Hi all.
Alexei Koudinov: Hello to everybody
Kiminobu Sugaya: Hi Wes, when you came to Chicago, you said long projecting neurons degenerating in AD can never be replaced.
Gabrielle: Hi Alexei, welcome, and hi Wes, guest of honor. Let's begin. Could you perhaps open the discussion, Wes, by restating briefly the key new developments that advance the neuroplasticity theory since we ran the interview with Dr. Mesulam? I will also throw out a question: according to the neuroplasticity theory, which is the earliest event that sets off the disease process in people without mutations in AβPP or presenilin?
Bruce Teter: Gabrielle's question on early events--if they are indeed synaptic loss as several reviewers have suggested--begs the question what causes synaptic loss, what are its signs, i.e. what markers can we look for early on?
Wes: Gabrielle, I would like to note that I did a search on neuroplasticity and Alzheimer on PubMed and actually found that Dr. Scheibel was credited with the first association. I made a statement in 1985 with Dr. Lissy Jarvik on the importance of plasticity, and I think that Marsel Mesulam's as well as Thomas Arendt's work reflect positively on that view.
Alexei Koudinov: Wes, I believe that earlier credit was associated with what we now call structural plasticity.
Kiminobu Sugaya: I would say adult neuronal plasticity is important in AD.
Alexei Koudinov: I would like to add that in my view the conclusions of both Siegfried Hoyer's pre-discussion comments (on insulin and cholesterol) could nicely add to our recent discussion on Alzheimer's vaccination, which was also about the rationale for tackling amyloid in AD.
Wes: I did want to respond to Dr. Hoyer's statements about insulin and metabolism. The earlier comments had to do with neuroplasticity in the sense that memories are laid down through the formation of new (structural) connections. But I think that the new statements only amplify the original ones by now showing what neurophysiological and neurochemical mechanisms are in play. It still seems that neuroplasticity relates to Alzheimer's disease at all levels, as was suggested before.
Alexei Koudinov: The plasticity as a way to fine-tune current neuronal/synaptic/field/etc action. I would like to add another background reference to the pre-discussion essay. That is Mesulam's article in Neuron, 1999.
Wes: This citation is included in my statement, that is an excellent paper.
Pascale Lacor:
Gabrielle: Steve Paul's and Dave Holtzman's groups have a paper today reporting that a one-time injection of an Aβ antibody improves' overnight' the performance of old PDAPP mice in a memory and a learning task (see ARF news story). Bill, you noted a fast-acting effect of ADDLs in PNAS a few years ago. So do we have an immediate effect of soluble Aβ on synaptic function here? How would that work? Anyone?
Bill Klein: ADDLs have a selective impact on LTP that is quite fast (Wang et al 2002)! We're very excited, by the way, about the results from Steve and Dave; they had mentioned them in the fall. They're in harmony with Dave Morgan's earlier studies in Nature that showed improvement by vaccination without much of an impact on amyloid deposits.
Gabrielle: That would strengthen a role for soluble Aβ directly on LTP. Any idea how that works?
Jacob Raber: Also fits nice with the growing evidence of cognitive deficits appearing before there are plaques.
Bill Klein: Here's a question -- how closely can we link mechanisms of functional and structural plasticity? If ADDLs block LTP, might they account for the structural synapse loss that Lennart Mucke reported in his amyloid-free mice (Mucke et al. 2000)
Keith Crutcher: I also would like to hear some discussion on this question of the precipitating events leading to AD. If we assume that the storage of new information (neuronal plasticity) is, by definition, required for memory, then dementia must involve a problem with plasticity. But isn't this a circular argument to some extent? Much as the definition that amyloid is critical to AD when its diagnosis requires the presence of amyloid plaques.
Alexei Koudinov: We also have to remember two 1995 articles that Aβ facilitates LTP (see e.g. Wu et al 1995), as well as several articles and meeting reports suggesting Aβ has a synaptic function rather than synaptic toxicity, as Selkoe's recent paper in Nature claims (see ARF news story).
Kiminobu Sugaya: Yep, I remember that. How about AβPP? Whenever neurons get damaged AβPP goes up
Wes: It still seems that Dr. Hoyer has not joined us, but he did append an elaborate statement to the original background text. His central issue is that the concept of plasticity leads to suggesting the systems in the brain affected by AD. However, Dr. Hoyer points to changes in metabolic functions. I believe that metabolic changes are secondary to the damage that is occurring to the neuronal processes. Regarding the vaccination issue, there is the fundamental problem of what normal role Aβ is playing in neuroplasticity, and that must be understood before trying to eliminate the substance immunologically. Good point, too, Alexei.
Angele Parent: Regarding fast-acting effect of antibody or Aβ, I would like to remind everybody that the plastic property of the synapse and associated memory process is intimately linked to the rapidity of synaptic response and remodeling.
Bill Klein: We think that it's possible to target (by vaccination) the nasty forms of Aβ, leaving behind the good Aβ (monomer). Vaccination with ADDLs gives the right type of antibody for this.
Jacob Raber: Why would monomeric Aβ not bind to the antibodies?
Bill Klein: Monomeric Aβ is "self" but assembled Aβ is "not self."
Kiminobu Sugaya: If the vaccination can destroy just Aβ deposition, it may be good. I thought antibodies recognizing the n-terminal of Aβ eliminate Aβ deposition, but others do not.
Wes: Kimi, I think there is a balance between the alpha and beta secretases, perhaps controlled by acetylcholine. A critical problem may be what leads to the 1-42, rather than the 1-40 Aβ. That may be extremely important in view of Koo's work, as well as the statements from epidemiologists that NSAIDs greatly reduce AD risk. (Any comments, Suzanne?)
Suzanne Tyas: Wes, the epidemiologic studies do provide pretty consistent support of a protective role of NSAIDs in AD. Epidemiology is good at flagging these types of associations, then it's up to the basic scientists to work out the mechanisms!
Gabrielle: Last Thursday's paper by Dominic Walsh et al. reports he injected low-n Aβ oligomers into adult rat hippocampus and that inhibited LTP. They did this to advance their argument that Aβ oligomers are toxic to synaptic function. How does this fit with the neuroplasticity theory? Data by Angele suggests that PS-1 transgenic mice have higher LTP induction, not an inhibition.
Angele Parent: Our study was done in mice where bAPP was not overexpressed. So we cannot factor in the effect of Aβ.
Gabrielle: Angele, but they had a PS-1 mutation, right? Does not this mutation lead to overproduction of Aβ?
Angele Parent: Gabrielle, LTP in PS1-mutant mice can be completely independent of the presence of AβPP, since it appears that PS1 may by itself alter calcium homeostasis and other intracellular functions.
Kiminobu Sugaya: If just PS-1 mutation did not change LTP in mice, it means mice Aβ does not work? Why is everybody injecting human Aβ into rat or mice?
Wes: Suzanne, the issue is that certain NSAIDs may be preventing the toxic Aβ1-42. So, this may be a major direction for preventing AD. In light of the other on-going discussions, as there is a greater neuroplasticity burden (to use Dr. Mesulam's term), there would be more Aβ produced, and a greater risk of producing toxic Aβ. So the NSAIDs could really help in this way.
Bruce Teter: Wes, I see no evidence/mechanisms for NSAIDs directly affecting plasticity.
Wes: Bruce, the work of Koo suggests that certain NSAIDs may work by modulating gamma secretase activity, and so prevent Aβ1-42, which is presumably being produced excessively when there is a high neuroplasticity burden. (On NSAIDs in AD, see ARF news story, see ARF news story, see recent NSAID chat.)
Alexei Koudinov: As we switch often to vaccination I have to route you to our recent BMJ eLetter. My reference to Selkoe is indeed the reference to Walsh paper in Nature. Two co-authors of this paper are also the authors of 1995 papers on Aβ and synaptic plasticity that I referred to above. I am curious why they do not discuss their earlier finding that Aβ is improving LTP
Bill Klein: Alexei, they're probably now using the new improved Aβ.
Alexei Koudinov: Maybe, Bill.
Kiminobu Sugaya: Bill, what does "improved" mean?
Bill Klein: Kiminobu, sorry; kind of a joke.
Bill Klein: Anyone -- Is there any evidence that Aβ might build up first in a localized way, at synapses?
Bruce Teter: Bill, evidence - none I know of, but ideas of low-density lipoprotein receptor-related protein (LRP)-mediated uptake of Aβ at synapses are enticing. I think there might be some studies on synaptosomes and Aβ.
Alexei Koudinov: Bruce, I agree that Aβ may have synaptic relevance through the LRP. Importantly, apoE isoforms may provide the difference as pointed out by the associated difference with the pharmacological treatment with the different transmitter agonist. (Cedazo-Minguez et al 2001). There is a meeting report (Kamenetz, SNF 2000) and a paper (Huber et al., 1997) on an activity-dependent increase of synaptic AβPP, and a paper that Aβ upregulates synaptic protein transcript (Heese et al., 2001).
Gabrielle: Dr. Mesulam refers to an increasing' "physiological burden of neuroplasticity'" with age. How does this fit with other studies that intense mental activity appears to protect from AD by creating a "cognitive reserve?" Does not mental activity create high demands, i.e. burden, on plasticity? You would think the most mentally versatile, active, changeable people would be "exhausted by the burden of plasticity'" first? Instead, their plasticity seems to be best "trained'" and thus protective. Am I getting this wrong?
Suzanne Tyas: Gabrielle, the issue of cognitive reserve strikes me too. One of the earliest and most consistent epidemiologic findings is the association between higher education and lower risk of Alzheimer's. Would more education reflect increased neuroplastic ability or increased burden?
Gabrielle: Suzanne, I would think both, and that is what puzzles me.
Wes: Gabrielle, this point of age and protection by use is very important and could make or break the theory. But, before looking at the question the way you have worded it, consider that early education is protective, that is, plasticity in the young individual. During that time, there are probably plenty of mechanisms protecting from AD. Later, those with greater reserves are able to solve problems using less cerebral metabolism, so are protected from such an excess burden.
Suzanne Tyas: Wes, the point about early education is interesting. Findings from the Nun Study showed a protective effect of education attained early in life. Further educational attainments acquired during adulthood were not significantly associated with subsequent risk of Alzheimer's.
Abraham Fisher: Hello to you all.
Gabrielle: Hello Dr. Fisher, and welcome!
Pascale Lacor: Kimi, did you ever see a change in dendritic spines in your AD model?
Kiminobu Sugaya: It is not an AD model. It is an amyloid model, and we have not checked spines in our animals in a specific manner.
Gabrielle: Is there any clear data on other molecular aspects of synaptic plasticity, for example mini-mRNA localization in dendritic spines, postsynaptic gene expression, etc, being affected directly by AD risk factors?
Pascale Lacor: Gabrielle, there is not much work on mRNA located at the dendritic spine and downregulated in AD models but it is time to look at that!
Kiminobu Sugaya: In our study AβPP increased stem cell differentiation. We have to check Aβ itself, though.
Jacob Raber: Soluble AβPPs?
Kiminobu Sugaya: Yes, soluble AβPP. Overexpression of AβPP by transgene did the same thing.
Alexei Koudinov: Soluble AβPP attenuated LTD (but enhanced LTP) in a paper by Mattson ( Ishida et al 1997)
Bill Klein: Alexei, interesting! ADDLs block LTP, not LTD, but LTD recovery is blocked, (Wang et al, 2002).
Alexei Koudinov: I also would like to address the earlier question on LTP and synaptic plasticity relation.
Bill Klein: Question -- what do you think of Barb Trommer's idea that a "shift" from LTP to LTD might lead to synaptic structural destabilization?
Alexei Koudinov: Important question, Bill. LTP and LTD are two different forms of synaptic plasticity. The lack of one (LTP) does not mean the gain of another (LTD).
Bill Klein: Alexei -- let me rephrase a bit. Since LTD is difficult to reverse in the presence of ADDLs, and LTP is blocked -- might this lead to structural destabilization, down-stream?
Alexei Koudinov: Bill - the change in both may have a structural basis.
Wes: Bill, Alexei, I am afraid my understanding of the precise mechanisms of LTP and LTD is not adequate to predict how each would fare in a brain being attacked by Alzheimer pathology. However, this is a central issue: Which of the two is attacked or are both? I would think that LTP would be a greater target, since that is the more human neuroplastic mechanism for making more widespread changes to store memories.
Gabrielle: Kimi, are you suggesting AβPP helps generate new neurons for plasticity and for replenishing dead ones in adulthood?
Kiminobu Sugaya: Gabrielle, yes in some sense. But at higher doses, it increases glial differentiation.
Pascale Lacor: Kimi, do you think, then, that AβPP is the receptor of something to target those new neurons?
Kiminobu Sugaya: I think it looks like a receptor, but our study indicates it is a messenger. I am proposing that AβPP is a signal from damaged neurons; it induces glial differentiation first and then causes neuronal differentiation as a result.
Pascale Lacor: Kimi, interesting.
Gabrielle: All who are interested in Kimi's differentiation data please note we are planning a live chat on AβPP function.
Abraham Fisher: Would anybody like to comment on the physiological role of Aβ? My hypothesis is that it is a regulating factor in muscarinic postsynaptic transmission.
Wes: Abe, welcome. I appreciate the article you sent me a year ago and hope my rendition on the web is satisfactory to you. Your paper suggests that acetylcholine, through the muscarinic path, has dual effects on reducing metabolic pathways leading to AD. I also believe that it is originally Dr. Mesulam's suggestion that the tauists and baptists could have their theories united by saying that each works on a related but separate aspect of neuroplasticity. Any comments?
Abraham Fisher: Wes, thank you. In fact I think that one has to be careful and not mix cholinesterase inhibitors with M1 agonists as far as AβPP processing is concerned
Kiminobu Sugaya: I also remind you AβPP has NPXY in its C-terminal, which is a DAβ1 binding site.
Wes: Kimi, your hypothesis that AβPP could serve as a signal to the glial cells is interesting, Clearly AβPP is going through either alpha or beta secretase pathways. There are several products from each. It seems that the alpha path would generate new synapses, while the beta path would lead to production of free radicals and eliminate synapses no longer needed. Clearly the glial cells would be involved in this.
Jacob Raber: Wes, the effects of AβPP and Aβ on glial cells might involve glutamate transporter activity.
Kiminobu Sugaya: Do cholinesterase inhibitors increase spine formation or protein synthesis in synapses?
Abraham Fisher: I know that ChE inhibitors can increase generation of AChE, but postsynaptically. This was shown both in preclinical and clinical studies
Pascale Lacor: NMDA is important for spine plasticity, does anybody know if acetylcholine is also a good "spiner"?
Bill Klein: General question: why does the cerebellum, which is relatively plastic, show minimal damage in AD?
Marsel Mesulam: Bill, structural plasticity might be identified by GAP43 and trkB expression. These markers are high in adult hippocampus but I do not believe they are high in cerebellum.
Alexei Koudinov: Bill, probably because cerebellum, as an evolutionarily older structure, has lower plasticity demands.
Abraham Fisher: How about the idea that the cerebellum is devoid of M1 receptors? If there are no such muscarinic receptors, vicious cycles that might involve it are not activated (Fisher et al 2000).
Kiminobu Sugaya: We recently checked cholinergic deficits in AβPP/PS-1 double transgenic mice, but we could not find much change in nucleus basalis of Meynert neurons, which provide major cholinergic input to the neocortex.
Bill Klein: All -- thanks!
Gabrielle: Does the neuroplasticity theory suggest a different approach to therapy/drug development from the ones currently pursued? Being perhaps more of a overarching concept, what can it contribute toward therapy development?
Abraham Fisher: I think this theory suggests that activation of M1 receptors is a viable therapeutic strategy.
Bruce Teter: Gabrielle, one therapy approach is to target the effects of apoE, which we have not gotten to yet, but this requires the additional complexity of pharmacogenomic approaches to apoE isotype-specific therapeutics.
Abraham Fisher: Regarding apoE therapy, do we need to increase apoE or decrease it?
Jacob Raber: Depends on the isoform.
Kiminobu Sugaya: Does that mean increase apoE2 and decrease E4?
Bruce Teter: Abee, apoE therapy would depend on your genotype, expecting that E4 should be decreased, while E3 or E2 increased, but this is simplistic. Thanks Jacob Raber - your fingers are faster.
Abraham Fisher: Bruce, Jacob, thanks. Bye to all.
Bill Klein: Bye to all... very much enjoyed chatting with you!
Kiminobu Sugaya: I would say do not alter physiological function of AβPP and Aβ. See you guys.
Marsel Mesulam: I enjoyed the discussion. Thank you.
Jacob Raber: Thanks to all.
Wes: Gabrielle, thank you for trying to get us to a cohesive view. I think that the neuroplasticity hypothesis suggests both where to look and how to understand the Alzheimer pathology. Then, anything that can affect those mechanisms is fair game for use in treatment. Abe is focusing on the M1 receptor, but it has been remarkable how much benefit the anti-acetylcholinesterase drugs are providing patients. We are currently saving the world billions of dollars, and more each year, through the use of these drugs. The next steps are to take the numerous other leads and put them together so that Alzheimer's disease is prevented. In each case, the effects of the drugs appear to relate back to neuroplasticity, and this hypothesis can be used to develop future therapies
Gabrielle: Intriguing pieces of an apparent connection between apoE4, cholesterol, and their effect on neuroplasticity keep cropping up, but I don't understand how the dots connect. How could this be made clearer?
Suzanne Tyas: Gabrielle, I agree that the connection with apoE, cholesterol and AD is unclear. The finding that high cholesterol may be beneficial in late life, in contrast to its detrimental effects on AD and other diseases in earlier life, is intriguing.
Keith Crutcher: Wes, you mentioned in your overview that apoE is critical for cerebral cholesterol transport. Do you have a reference for that?
Bruce Teter: Keith, I can provide you with references to recent reviews on CNS lipid metabolism.
Keith Crutcher: Thanks Bruce. I was wondering especially if the apoE-null mice have problems with cholesterol in brain.
Wes: Keith, I think that the apoE is another central issue here. The best discussion of the subject is in the discussion submitted by Rebeck, Kindy, and LaDu, which will appear in the July 2002 Journal of Alzheimer's Disease. One thing I believe is that the ApoE4 was the old version, the only version until 300,000 years ago, and the E3 and E2 subsequently appeared, basically, nature showing us one way to reduce or eliminate AD.
Keith Crutcher: Wes, I think it is an interesting observation but I have to confess that the idea of AD being a strong selective pressure is a bit of a stretch for me.
Alexei Koudinov: Unless we delete the nature effect with the new food era (see our above paper for some citations). By the way, we have in today's Neurology issue a contribution on cholesterol and Alzheimer's (Koudinov et al 2002)
Bruce Teter: Wes, Keith, evolutionary pressure of AD -I agree it is weak from our experimental biologist view, but something drove apoE evolution, although it may simply be diet, with AD being an unfortunate bystander.
Keith Crutcher: Bruce, that seems more reasonable...a pleiotropic effect.
Wes: I was just trying to make a summary statement, that we need to get Rebeck et al's review to clarify the relationship between cholesterol, apoE, and neuroplasticity. Also, regarding treatments, you can check my "top 10" at www.medafile.com.
Keith Crutcher: Wes, how about the issue of circularity in the neuroplasticity theory?
Wes: Keith, I myself have to circle out of here. I think that the issue of neuroplasticity is the central theme at all system levels. This goes more toward an all-encompassing theory. There are certainly many other theories that can be compared to neuroplasticity, such as free radicals, metabolism, aging, but none of these point to all of the changes in Alzheimer's disease at all system levels.
Bruce Teter: Wes, thanks for starting this discussion. Clearly a multifactorial issue requiring multitasking for this kind of discussion. I'll keep in touch.
Keith Crutcher: Wes, thanks for the time.
Wes: Thanks to all, bye.
Alexei Koudinov: Bye, and thanks for discussion. It is time for dinner here in the Middle East.
Gabrielle: This is a fascinating theory that provides a good umbrella for disparate lines of research. Thank you all for your time and thoughtfulness.
Reference: Kamenetz, F.R., Tomita, T., Borchelt, D.R., Sisodia, S.S., Iwatsubo, T., Malinow, R. Activity dependent secretion of b-amyloid: roles of b -amyloid in synaptic transmission. Soc Neurosci Abstr. 26, 491 (2000).


text:
It is not too late and you are not too old. I know it's frustrating – even a little scary. But you can do this. What does happiness with a man look like to you? Is it feeling safe and at peace, feeling hot and adored? Is it knowing that you have a constant companion who has your back…or all of the above?
Whatever your dream, whatever your challenge…I am here to support, guide and educate you to gently (yet purposefully!) move you toward your goal of finding that One Man who will love and adore you for the rest of your life.
I offer several coaching programs to help you Find Hope and Find Him. Whether you prefer working with me 1-1 in person, on the phone, via Skype or via email; or you prefer the dynamic of a group setting…I have a program that matches your very special needs and your preferred style.
How I support and guide you to the love you so deserve:
Find Hope and then Find Him: 1-1 Private Coaching ♦♦♦ Spruce Up Your Online Love Life: 1-1 Private Coaching
Stay on Course: Monthly Email Support ♦♦♦ Course Correct: Monthly Email Support and 1-1 Private Coaching
My coaching is based on my practical and proven 6-Step Find Hope and then Find Him system, which guides you through:
Step 1: Who Am I? Falling in Love With Myself- Own how utterly attractive you are, especially to single men.
Step 2: Who is He? Getting Past My List – Learn the difference between a good date and a good mate by getting crystal clear about the man and relationship that will truly make you happy.
Step 3: I'm Fantastic, So What's the Damn Problem?- Name and clear the old "stuff" that's getting in your way.
Step 4: Casting the Net: Where is He and How Do I Meet Him? – Learn about the many places you can go and things you can do to meet single men. Then learn how to initiate and maintain conversation and get him to ask you out. (Online and off — using my step-by-step scripts.)
Step 5: From Rendezvous to Romance – Learn how to relax into your dates as you flirt with flair, keep him interested and learn what you need to know about him so you can make a good choice.
Step 6: Should I Stay or Should I Go? – Learn the specific questions to ask and things to consider when deciding if he's a potential great mate. If he's not, learn when and how to leave.
Learn more about me and Date Like a Grownup coaching:
More about Bobbi ♦♦♦ What my clients are saying
Find Hope and Find Him
I truly believe I am in love for the very first time. This relationship is so different from any other … I can't express enough how working with you has changed my life…even though I was a very big skeptic. ~ Debbie 53
For the woman who is ready to bring love into her life and knows that She's the one who needs to make it happen.
When you are in my Find Him and then Find Hope Program, I am your personal coach for four months! You will transform from the sick-and-tired single gal to the proud, grownup, empowered woman who has 100% hope of getting that love and companionship you have wanted for so many years. And you know how to find it!
This comprehensive "Find Hope and then Find Him" program gives you the gentle support, must-have information and tangible tools you need to get out there, meet good men and find the one who becomes your loving life partner.
You will break free from years of the fears, worries and beliefs that have had you paralyzed or stuck in the same negative cycle. You will feel proud and worthy and clear about the man and relationship that will make you happy. You will be in control of your dating process and able to attract the men you like who are ready for relationship.
Honestly, this is not for the uncommitted. Your best results come when you are willing to dive in and stay focused during our time together. I am here to be your mentor, teacher and absolute biggest cheerleader. Ultimately, though, it's you who will be open to new information, willing to step outside her comfort zone and take direct steps toward meeting fabulous men. (Remember, all it takes is ONE!)
More information | Signup and get started!
During our time together you will:
- Feel confident as a woman worthy of the love of a good man by rediscovering and falling in love with yourself.
- Eliminate the exhaustion that comes with dating by having clarity about how to share who you are in a positive yet 100% real way.
- Pick the men you'll be happy with and dump the rest because you'll know exactly what you want in a man and relationship.
- Stop getting the same bad results by identifying your self-sabotaging thoughts and acts and managing them once and for all.
- Truly enjoy yourself on dates because you have a true understanding and appreciation of men.
- Be the woman whom men want to date, not just be friends with.
- Get what you want and need from men by learning how to communicate in a kind and clear way.
- Find that special man to share your life and your love!
$4200 (Payment plans may be offered under certain circumstances)
More information | Signup and get started!
Spruce Up Your Online Love Life
I have been online for 5 years on and off and never gotten this kind of action. And the guys are good potential matches…not the losers I was used to hearing from! And when I email them they actually read it and most respond. Just like you said would happen! ~ Katie 50
This program is for the online dater who is new to this, hasn't had much action, is attracting the wrong guys or is going back online after a "hiatus." I met my husband online, as have many of my clients and millions of other women around the world. You can too!
There is definitely a right way to get results online. You will learn how to spruce up your online love life so you can STOP being exhausted, frustrated and disappointed…and START meeting smart, interesting, relationship-minded men…now!
Warning: This coaching program is only for you if you are willing to do online dating in a very different way….because the way you're doing it is NOT working.
You are here reading this because what you're doing is not working. Remember the definition of insanity: doing the same thing the same way and expecting different results. Online dating can be a complete bore, a nightmare or a really fun way to meet men and get practice.
If you have spent hours online and all you have to show for it is a ton of emails from the wrong guys…or you think that even though there are thousands of men out there you just can't find any that interest you…or you are just R-E-A-D-Y and want to stop guessing and get this DONE…this program is for you.
During our work together, I will support you by:
- Helping you understand how men and women differ when using online dating so you stop taking things personally and start feeling powerful, effective and in control.
- Reviewing men's profiles with you to help you spot the ones who show great potential and pass by the liars and scammers. (Learning how to judge profiles in a different way is the key to increasing your opportunities so you can start meeting good men who are looking for a woman just like you.)
- Deciphering emails you receive to help you stop being overly critical and missing opportunities, spot the keepers and stop wasting your time on the game players.
- Giving you a proven formula to follow when you write emails so they get opened, get responses and get you dates. (Yes…you won't be just sitting back waiting, you will be writing the men who interest you.)
- Teaching you how to get the the men you like to do things the way you want them done; from the first email to the first date. (Not only will asking for what you want not turn them off..it will turn the right guys on!)
How will you learn this? I actually hop online with you! I will review men's profiles with you, pick some good guys for you, and write and critique your emails. (Yes…I will actually give you the words to write!)
And most of all, I will keep you accountable for not giving up and making the best of your online experience.
(Note: This program is designed to get you set up online to get dates; it does NOT support you as you date.)
Here is how I support you when you sign up for my Spruce Up Your Love Life program:
- A Professional Profile Makeover
- Coaching for Professional photo shoot (Agreeing to have professional pictures taken is a MUST in this program. I will coach you on what to wear, how to pose, and give you referrals to photographers in your area. I will then help you select the photos to post with your new profile.)
- 4 (Four) One-on-One private coaching sessions (First session 90 minutes, remaining 50-minutes conducted by telephone or via Skype OR can be done in 2-hour intensive session plus two 50-minute sessions )
- Unlimited email support for 2 (two) months
And this BONUS: Access to my powerful, info-packed 3-hour Find Love Online webinar recording. (Value $127)
This is about giving you a kick-start with a new profile and a new way to look at your online connections. Note that it is not designed to support you as you meet and date.
Don't give up! I will give you a kick-start with a new profile and a new way to look at your online connections.
$2550 (Payment plans may be offered under certain circumstances)
Stay on Course: Monthly Email Support
"Sure…I get dates, but it never seems to work out. The same thing keeps happening over and over." ~ Carol 61
Have me on hand for those occasional times you need me to answer a question or give advice, save you from yourself or give you that "atta-girl" that keeps you positive and moving forward.
When you're on a positive path—enjoying dating or developing a relationship with someone special—a well-timed reminder or a piece of expert advice or concurrence that you're making the right decision can make the difference between returning to being dateless or losing that potentially great guy and being in that loving relationship you've always wanted.
This program is perfect for you if you have questions or needs that can be addressed with specific support and guidance as they that come up during the month. I will answer burning questions, help you write that email or tell him that thought, or give you my take on a particular situation. I will keep you on track and headed toward a promising relationship with a good man.
Ask me any direct question, like:
- Can I ask him where he thinks our relationship is going?
- How do I get him to ask me out without acting too forward?
- Do you think he's into me?
- How do I tell him about my health problem/ugly divorce/fear of STDs/etc?
- How do I break it off with him?
- When will I know it's the right time to sleep with him?
This is an incredibly small price to pay to have me standing by with advice that could give you an "ah-ha" moment to:
- Reinforce your confidence and feeling of hope.
- Give you new ideas for things to do and things to say to get you that date or strengthen your relationship.
- Prevent you from making the wrong move and ruining a potentially great relationship.
- Keep you from spinning out of control while trying to figure out what he's thinking, what to expect next or what to do next.
Here is the support you get when you sign up for my Stay on Course program:
- I will answer up to 4 email questions from you each month.
You choose the timing and the topic of each question. I'll give you information, advice, new perspectives…I'll even give you exact words to say. Most of all, I'll give you the individual support you need to get through a moment and on to your dreams.
I will respond to emails between 8 AM – 6PM PST Mon- Sat. You can expect a response time of eight hours or fewer.
Note: This program is only for you if you are successfully dating or in a relationship and in need of occasional, pin-pointed support. Your requests should be specific in nature. I will always give 100% focus and priority to every one of your emails, giving you the best possible support. However, if you have more complex situations and needs, these should be addressed in person-to-person communication.
$225/month with a minimum 3 month commitment
or $250/month
Course Correct: Monthly Email Support and Live Coaching
"Things were going great and then I had somewhat of a meltdown, and was going to do something really dumb. I'm so glad you where there to stop me!" ~ Sue 47
Get to the heart of the belief or behavior that's consistently resulting in bad dates or failed relationships. Start breaking through your "stuff" and putting an end to your constant disappointment – once and for all.
IMAGE If you've been dating but are experiencing bad results in the same area, this blended coaching program may be for you. Maybe you're challenged with something like:
- Wanting to learn how to ask for what you want.
- Keeping men from losing interest after the first date or two.
- Continually meeting men who seem to be interested only in having sex or just being friends.
- Picking the same type of guy who just isn't giving you what you need.
- How to feel more comfortable being feminine so you attract more masculine men.
I will help uncover your beliefs and behaviors that may be creating these recurring situations. Breaking one particular pattern or learning one single skill is sometimes the only thing standing between you and that spectacular relationship.
MORE In addition to getting information and my expert advice, use my compassionate encouragement to remind you how much you have to offer and help you stay on your path to meeting your Mr. I Love You. (One of my main responsibilities as your coach is keeping you focused and moving forward so you don't give up!)
For these kinds of specific yet deeper questions and a more intimate connection, each month you will have my support in two ways: via email and in one personal one-on-one session.
Here is the support you get when you sign up for my Stay on Course program:
- As with my Stay the Course program, I will answer 5 emails each month at the time of your choosing.
- One private 50-minute telephone or Skype session with me during the month. This session can be scheduled with up to 36 hours notice; depending on availability.
I will respond to emails between 8 AM – 6 PM PST Mon- Sat. You can expect a response time of eight hours or fewer. Once registered, you and I will set up a time for our phone session.
Note: This program is for you only if you are meeting men dating or in a relationship and are thus in need of occasional, pin-pointed support. Your requests should be specific in nature. I will always give 100% focus and priority to every one of your emails, giving you the best possible support. However, if you have more complex situations and needs, these should be addressed in person-to-person communication.
$450/month with a minimum 3 month commitment
or $500/month
More information | Signup and get started!
I am 100% committed to guiding you expertly and safely in your movement toward your goal of dating like grownup. I will create a structure for your progress, keep you on track and accountable, provide ongoing instruction, and always give you my full support and loving kindness.Here is how to get started and get your questions answered.
Call me at 562.608.8685 or email me and let's talk further about my programs and which may be right for you. You may qualify for my Complimentary Strategy Session.
Let's get you on your own path to becoming a happy and successful dater. (There are great men out there waiting for you!)
I realize that for some my personalized coaching is not affordable or is not your preferred way to move forward in your search for love. If so, I suggest you give me a call and let's talk about my next Mastering the Mystery of Meeting Men after 40 Telecourse or my other homestudy programs. I offer you many ways to Find Hope and then Find Him!
With my unconditional love and support…and admiration for your commitment to getting what you want in life.
Click here to email me at firstname.lastname@example.com
Or just pick up the phone call me at 562.608.8685
Let's get started!


text:
Hey Spammers. I know that some of you are actually really fantastic advice givers, so I'm going to leave this here in hopes someone can help me. I'm having a hard time. I know it is lengthy, but please give it some thought if you have the time.
My boyfriend and I have been together since middle school (barring a short break in 10th grade). We are now going into our senior year of college. My boyfriend spent two years at a community college to get his basics. I went straight to a four year university. This time last year, my boyfriend was accepted to the same university.
He went into the engineering program, and did terribly. He failed most of his math classes, and some he went on to fail two more times. I kept asking him, is engineering really where you want to be? He kept saying yes.
At the end of last semester, his GPA fell below a 2.0. He didn't even get enough credits to move from sophomore to junior. The university put him on probation, and he was kicked from the college of engineering. He tried to retake his math class, to get back into the college and raise his GPA, but he failed it. Now not only has he been kicked from the college of engineering, and informed that he should not reapply, he was dropped from the university for a year. He will try to appeal it, but I have little hope.
I'm having a very hard time with this. I've been pushing him and pushing him, but he just won't improve. He blames the professor, the school, the work, and occasionally, he admits he isn't trying hard enough. I'll be the first to say he does come from a family of lazy, apathetic people who don't work and live off of disability. They have never gone to college. But I expected more of him.
My parents are growing pretty turned off by his behavior, and I'm really annoyed myself. He keeps talking about how all he wants is to graduate, but then he won't put in the work to do so.
I know there is only so much that I can do, and he has to choose for himself, but all he talks about is being an engineer. I recommend other majors, and even after he knows he cannot study engineering at this university, he won't even talk about it.
How do I find the balance between being supportive and being realistic? Is there anything that I can do in this situation at all? Has anyone been through something similar? I'm just all over the place right now. :\


text:
Gap Filling Optical Adhesives/Epoxies
"I need an epoxy to join two BK7 glass parts together. Gap is around 0.2mm. Light will cross the interface. Reasonable index match to the glass required. Low stress/shrinkage so it doesn't distort the parts please. Viscosity not too runny, as we want it to stay in place prior to cure."
Optical glass-bonding adhesives are available that have good adhesion to BK7 Glass, a close refractive-index match to the glass, low shrinkage (low modulus), and moderate viscosity to avoid running. Light-curable adhesives like OP-29, which is a one-part adhesive from DYMAX, are available exclusively through Fiber Optic Center. FOC also carries various 2 two-part epoxies or 1 one-part frozen epoxies which should meet your requirements. An alternative source would be to visit the Edmund Scientific website and review their adhesive selections. Epotek 353-ND and 353-T epoxy are also widely used in the glass-bonding/optical adhesives market.


text:
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text:
The Burnaby Devlis won the Tier 2 under-14 Richmond Roadrunner Romp field lacrosse tournament played last weekend.
Burnaby won a thrilling gold-medal final 9-7 against the Bellingham Stealheads.
Tavin Grant led the way with three goals, while Josh Dumont chipped in with a pair in the championship final. Mack Burns, Joel Sinclair, Tristan Dalin, and Liam Smith also tallied for the Devils.
The final was a see-saw battle with Burnaby trailing most of the first half before tying the game 5-5 at the break. But solid defense from Robert French, Tate Wallace, Brendan Zaph, Brent Rittenburger, and goaltending from Brandon Toor shut down the Seelheads in the second frame.
There was outstanding mid-fielder play from Burns, Grant, Dumont, Lucas Olheiser, Mitch Darazio and Sinclair were outstanding in the midfield. Attack men Sam Harper, Brady French, Smith and Dalin kept the Stealhead long poles on their toes all game long. Burns was also outstanding on face offs and Grant kept Bellingham mystified all game long with his penetrating attacks.
The u-14 squad started round-robin play with a convincing 9-1 win over Ridge Meadows, and followed it up with a 10-1 victory over Seattle Starz, and an 18-3 romp over Delta. Burnaby qualified first in the division and defeated a mid-Island team 15-4 in semifinal play.
Individual game stars throughout the tournament were Smith, Grant, Darazio, French, and Toor.
The Richmond Romp is the premier field lacrosse tournament in the Pacific Northwest with teams travelling from the B.C. Interior, Vancouver Island and Washington State.
© Copyright 2013


text:
Results 1 - 6 of 6 matches
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text:
The Four Winds West Class: Karma and Past Lives
[Prerequisites: South Course]
Just as the jaguar has no predators in the jungle, learn to have no enemies in this world or beyond. Step into the shoes of the luminous warrior by breaking free from the grip of any ancestral karma or family "drama," and prepare for a more enlightened journey.
In The Four Winds West class, you will have an opportunity to explore ancestral karma that propels you toward a certain destiny. As you shed the emotional baggage you inherited from your family of origin, you break free from past lives and generational curses passed down your family line.
This class will be taught by Lara Marie Obermaier in English with German translation
€1650 EUR – Standard Course Price
Discounts are available for purchase of multiple courses. Call us toll-free: (888) 437-4077 or e-mail firstname.lastname@example.com
To Register:
Thank you for your patience as we upgrade our online registration system for areas outside of North America. You can register for this course as follows:
- By phone: For your convenience, contact Lara'Marie Obermaier in Germany at +49-8380-9834931. Or, call us toll-free: (888) 437-4077, or call (435) 647-5988,
Venue/Lodging Reservations/Dining Information:
Jonathan Seminarhotel *Please note: The Tuition fee does not include accommodations at the venue or meals. When you enroll for the program, you must also register with the venue, even if you are staying off-site.


text:
Cedar Bluff Reservoir
Kansas Department of Wildlife & Parks Cedar Bluff Area Office 785-726-3212
13 miles South of I-70 Ogallah Interchange (exit 135) on K-147
GPS Location: 38.7961 -99.7244
Ellis, KS 67637
Impoundment Type: Reservoir
Surface Acres: 6,869 @ conservation level
Maximum Depth: 48'
Normal Lake Level: 2144' MSL
Current Lake Level: 2119.00' ----25.00' below conservation
Lake Temperature: 47
Fishing Population | Creel Limit | Min Length Limit |
Walleye | 5 | 18'' |
White Bass | No Limit | |
Crappie | 50 | |
Wiper | 2 | |
Channel Catfish | 10 | |
Largemouth Bass | 5 | 15" |
Smallmouth Bass | 5 | 15" |
Spotted Bass | 5 | 15" |
Flathead Catfish | 5 |
** Striped Bass or Wiper in Combination
*** Walleye, Sauger or Saugeye in Combination
Fishing Report - Last Update: 12/5/2013
Species |
Rating |
Size |
Baits, Method, & Location |
Crappie |
Slow |
Up to 15 inches |
Vertically fishing small slab-spoons over the fish attractors or over steep drop-offs in deep water has been best, but anglers only report catching a few fish each outing. |
Rainbow Trout |
Good |
0.5lb./fish average |
The first trout stocking of the season occurred on October 28, 2013 with the release of 1,750 rainbow trout. Overall the fish stocked were quality fish and averaged approximately 0.75 lb. per fish with fish up to 3 or 4 lbs. available. Anglers have reported catching limits on occasion with the most of the fish kept running in the 13 to 15 inch range. Casting in-line spinners has been best, but corn, worms, salmon eggs, and powerbait may be options as well. |
Walleye |
Fair |
Up to 28 inches |
Anglers report catching a few fish vertically fishing slab spoons over points, drop-offs, and around the fish attractors. Fish are running fairly deep so start at 25 feet and don't be afraid to try deeper. |
White Bass/Wipers |
Fair |
Whites up to 17 inches Wipers up to 13 lbs. |
Vertically fishing slab spoons over deeper drop-offs and points has produced both species. Most whites have been 12 to 15 inches in length and are fat and health yielding nice fillets, and most of the wipers have ranged in length from 14 to 19 inches and are in good shape too. |
The boatramp east of Cove 3 in the wildlife area is open for the near term, but use caution when launching as the ramp does not extend real far out underwater. Launching large boats that require a longer ramp might be treacherous. WATER TEMPERATURE-42 SURFACE ELEVATION- 2118.92'----25.08' below conservation It is illegal to release fish into public water unless it was taken from that water. So please discard any leftover bait in a trash can. Cedar Bluff District Newsletter: A biannual newsletter detailing fishing related prospects and activities in the Cedar Bluff District, which includes such waters as Cedar Bluff Reservoir, Sheridan and Scott State Fishing Lakes, Antelope Lake, and other public fishing waters in northwest Kansas are available. If you would like to subscribe to this newsletter you can go to the following link to get on the mailing list. The link is: http://kdwp.state.ks.us/news/KDWP-Info/News/Newsletter-Request-Forms/Request-a-Newsletter-for-the-Cedar-Bluff-Fishing-District |


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We live in USA basically from Andhra Pradesh, we wanted to visit Rameswaram to perform Sarpa Dosha puja. We wanted to this from longtime, and finally we planned it this year in September. Based on TripAdvisor ratings & reviews, I started calling different hotels to check for information temple timings, Sarpa Dosha puja related information like priests & specific days/times... More
- Also Known As:
- Royal Park Hotel
- Reservation Options:
- TripAdvisor is proud to partner with Travelocity, Hotels.com and Tingo so you can book your Hotel Royal Park reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.


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Healthcare jobs in Australia
Medacs Healthcare is currently recruiting internationally for a number of different healthcare professions across Australia.
We have positions available for all medical professions in city, rural, coastal and outback locations and use our expertise in dealing with the red tape of immigration, visa applications, obtaining registration and provider numbers.
We provide
- A free service to all candidates
- Interview techniques/advice and salary negotiation
- Local information and lifestyle guides
- Processing of registration and visa applications
- Expert advice and assistance throughout your entire transition
Check out some of our jobs below or click the quick links for more information about jobs in your profession.
You can register you interest in Healthcare jobs in Australia on our Australia website here.
Medacs Healthcare are currently recruiting for jobs in the following healthcare professions in Australia - simply click on the links for further information:
- Dental
- Dietitians
- Doctors
- Nursing
- Occupational Therapy
- Pharmacy
- Physiotherapy
- Radiography
- Speech and Language Therapy
Register your interest in health care jobs in Australia on our Australia website.
Australia is a vast country with lifestyle choices to suit all tastes. Whether you are interested in moving to Australia to gain professional experience, improve your quality of life, or just have a fun-filled working holiday, we are sure to have the ideal option for you.
Most of the population choose to live along the extensive coastlines - and with Australia boasting over 7,000 beaches you can see why. It is the sixth largest country in the world and is made up of six states: Queensland, New South Wales, Victoria, Western Australia and Tasmania and two territories; Australian Capital Territory and Northern Territory.
Australia is a diverse, modern, sophisticated, yet affordable country. The multicultural population has provided a huge choice of affordable restaurants specialising in a variety of international cuisines. And, as eating out in Australia fairly inexpensive, you can afford to treat your tastebuds regularly!
With lively music scenes, pubs, hotels, movie and arts industries, there is a range of entertainment for all tastes. Being a nation of sports fanatics, there is a plentiful supply of quality sporting venues - offering the choice of participation or spectating.
With climates ranging from tropical to temperate, there is sure to be an ideal location for you, whether that involves surfing at one of Australia's many beautiful beaches or snowboarding down a ski slope.
For nature lovers, Australia offers vast areas of national parks, filled with uniquely Australian native plants and fauna. And, with a population density a fraction of most countries, it's very easy to find a quiet spot when you want to escape the city life.
Register on our Australia website now for healthcare jobs in this exciting part of the world.
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DeGette, Diana
The latest news on DeGette, Diana
A bill has been reintroduced in Congress that would effectively end the sale of ammunition online and by mail.
High-capacity magazines define our nation's mass shootings.
Some members claim the White House visitor logs are not useful.
Issue could mobilize conservative voters in midterm elections.


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Clock changes in Tripoli
Tripoli, Libya Tripoli is also known as Tarabulus Tripoli is the capital of Libya | |||||||||||||||||||||||||||||||||||||||||
Time change dates in 1990<1989 | 1991> | Choose year... | |||||||||||||||||||||||||||||||||||||||||
Standard Time Zone was changed May 4 | When local standard time was about to reach Sunrise and sunset will both be about 1 hour later on May 4, 1990 than the day before: More daylight in the evening
Background info: Libya Changes Time Zone | ||||||||||||||||||||||||||||||||||||||||
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Time Zone Calculators for Tripoli
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- Event Time Announcer/Fixed Time – Show local times worldwide for your event.


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Congratulations Cobol 50 years!
Cobol – COmmon Business Oriented Language – is one of my favorite languages and the one I'm absolutely most impressed with. It is one of the oldest programming languages that are still in active use. At this time it's 50 years since Grace Hopper created Cobol and the first compilers was subsequently implemented during the year 1960. At December 6th and 7th 1960 essentially the same Cobol program was run on two different make of computers, an RCA computer and a Remington-Rand Univac computer.
Here's some facts that you most likely didn't know about Cobol:
1. According to a survey done in Great Britain and USA people are in contact with Cobol around 10 to 13 time every day.
2. Of 310 billion line of software that are in use today over 200 billion lines are Cobol, that's about 65% of the total software.
3. Every day 5 billion lines of new Cobol code are produced.
4. 80% of all daily business transactions are processed in Cobol.
5. 70% of all mission-critical applications are written in Cobol.
6. 2 trillion dollars is the total investment in Cobol systems.
And of couse the famous Hello World for everyone that doesn't know what Cobol looks like:
IDENTIFICATION DIVISION. PROGRAM-ID. HELLO-WORLD. PROCEDURE DIVISION. MAIN. DISPLAY 'Hello, world.'. STOP RUN.
Tags: Cobol


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Taylor Swift scores major style points at the MTV VMAs for her retro-look curly blonde 'do. Hello, Marilyn.
Chloé engraved Signature fragrance, from £42, Harrods (Knightsbridge) from 2nd -20th December and also in House of Fraser in Glasgow on Friday 20th December »
I don't tend to believe in overnight skin miracles – or to be more precise in three day ones. But if better skin starts on you plate then it's worth a go. »


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life is written in code and one can learn to navigate through a mathematical system...there has to be an order behind this madness known as the stock market.
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Rachel Welte is the Weekend News Anchor and a General Assignment Reporter.
COLORADO SPRINGS, COLO. -- Fort Carson honored one of their own Tuesday afternoon.
Staff Sgt. Patrick H. Quinn died October 13 when his base was attacked with small arms fire.
Quinn was assigned to the 3rd Battalion, 10th Special Forces Group at Fort Carson.
Family, friends and fellow soldiers filled the Soldier's Memorial Chapel on post for the emotional memorial that included a traditional roll call, rifle squad salute and final playing of the taps.
"Staff Sgt. Quinn was a professional, he was determined and a hard worker," Major Aram Donigian, Public Information Officer with the 10th Special Forces Group, said. "He is remembered by his teammates as incredibly honest."
Those who knew Quinn said he was a great representative of our nation, someone who volunteered four times.
"He volunteered to join the army, to become an infantryman, to join airborne school and then to become a Green Beret," Donigian said. "He was very proud to wear the uniform."
Sgt. Quinn's comrades said his death is a tremendous loss for his family and the army. He leaves behind a wife and three young sons.
"He was a family man, he loved his wife and he loved his kids," Donigian said. "In every way he embodied the spirit of the Green Berets, and we will do our best to keep that alive."
Moving forward his teammates said they will continue to serve in a way that honors his memory, and those who have gone before. Whether it be in Afghanistan or other places in the world that are faced with oppression.
"Remembering him today helps everyone who is part of this organization remember why we serve," Donigian said.
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Terrain Navigator - Topographic Map Software
Topographic mapping software for recreational or professional use.
What is Terrain Navigator?
Terrain Navigator software gives you a regional collection of topographic maps that you can browse, customize and print with your Windows computer. The sofware allows you to view a complete, seamless topographic map collection covering your entire state. The maps in Terrain Navigator are high quality scans of the US Geological Survey 1:100,000 and 1:24,000 map series.
View and print scenes from USGS 1:24,000 and 1:100,000 topo maps
Seamless or quad sheet viewing and printing on standard printers
View as flat 2D maps, 3D landscapes and topographic profiles
Tools for latitude/longitude, distance, area, datums and more
Customize your maps with symbols, text, photos
Plan routes on your computer and upload to your GPS
Mark GPS waypoints and tracks in the field and download to your computer for display
Search for locations by coordinates, place name, quad name and more
View aerial photos in the map window via the internet
Street address look up and navigation
Advanced drawing, symbol sets and map annotation tools
GeoPins attach photos, documents and spreadsheets to map locations
Export maps and air photos to popular GIS and CAD software
Print large maps on large-format plotters
NGS benchmark and up-to-date recovery sheets
System Requirements:
Windows operating system, DVD-ROM drive. Internet connection required to install the software, access aerial photos and updated topographic maps. When you install Terrain Navigator Pro software the most recent version will be downloaded to your computer.
Topo Maps:
A full set of topographic maps for the region/state that you purchased will be on the DVD that accompanies the software. You have full access to view these any time that you use the software.
Aerial Photos:
For the first year you will have full access to aerial photos that are delivered to your computer via the internet. They will appear automatically as you browse and be saved on your hard drive. At the end of one year you can continue viewing the photos that are already saved on your computer, but to access aerial photos of new areas or updated aerial photos you will need to pay a subscription fee of $99 per year (the photos in the online photo collection are refreshed at an average rate of about once every two years). If you don't plan to subscribe you should view the aerial photos of your interest areas within one year of installation so that they will be saved to your computer.
This website is owned by Digital Map Store
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Images, code and text on this site are property of Digital Map Store
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Those of you who don't know what dead space is:
Dead Space is a third-person survival horror video game, developed by EA Redwood Shores (now known as Visceral Games) for PlayStation 3, Xbox 360, and Microsoft Windows. It is the first installment in the Dead Space (Series) and was released on October 14, 2008 on the consoles and October 20 for Windows. The player takes on the role of an engineer named Isaac Clarke, who battles the polymorphic undead species called the "Necromorphs" on board a stricken interstellar mining ship named The USG Ishimura.
Plot Summary: This takes in the year 2518, ten years after the USG Ishimura incident.
Your are on a Colonial colonization ship named, S.S Groundhog. You and your fellow colonizers are ready to colonize a planet in the far reachs of the Expiratia system. This planet is known to many as the Death's star or Volgun Hyier. The planets actual is GT45 with its red like appearence. You feel as if something is wrong about the planets name, but you don't worry about it. But deep within the cargo bay hides something sinister... A fragment of the marker is being trasnported with the colonizers in a safe tube, but thats not the only worry. There have been repots on the ship that people have been hearing voices in their heads and then a few short span of days the commited suicide. The last remaing people are deciding whether to turn back or keep going unaware of the Marker's presences on the ship. Later creatures start to appear on various points of this large ship, the people are familier with the Necromorph species but never really realized it would happen to them. They are fearful for their safety and abandon the ship later that earth-day. The ship now floats aimlessly in space with blood staining the walls of its interior. Then reports came in into the Colonial Society, and then send in quarantine soldiers to search for the missing onboard the S.S Groundhog. The found that they were a handful that stayed behind, but told them that they went to nearest planet which is TY89 "The Blue Ground". Now the Colonial Quarantine soldiers and the Survivors face a disaster of nightmarish proportions. Will they make it out alive or will they die trying?


text:
Posted: Jan 21, 2013 10:25 AM
Updated: Jan 21, 2013 1:20 PM
CORPUS CHRISTI - Homicide investigators with the Corpus Christi Police Department are asking for help finding the person responsible for the suspected murder of 20-year-old Michael Sandoval on Sunday.
Police say Sandoval was found unconscious and later pronounced dead at his garage apartment in the 1500 block of Wynwood Drive around 2:30 p.m. yesterday.
If you have any information, call Crime Stoppers at 888-TIPS, or submit a tip online at www.888tips.com.
Do you have a tip, information about a breaking news story, or a story idea for 6 Investigates? Contact the KRIS 6 News Desk at 361-884-6666 or send us an email.
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This item is currently sold out or unavailable online.
Or, may we suggest shopping for similar items:
This page is provided for reference to historical product information.
Please note: CamelBak products can only be shipped to U.S. addresses.
Item 811624
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Best Uses
Comments about CamelBak Hydrobak Hydration Pack - 50 fl. oz.:
More color availability would be ok, black is not good for hot weather.
Best Uses
Comments about CamelBak Hydrobak Hydration Pack - 50 fl. oz.:
I was looking for a less encumbering way to hydrate on long 'out-and-back' runs, and I figured I'd give this one a shot. Price and size were my main concerns, and this bak did not disappoint. Hydration belts are great, but this compact bladder is better - highly adjustable strap length (and I'm small, so it matters), negligible added weight that is well-distributed, and liquid stays surprisingly cool in the main hold, even after 3 hours with your back to the sun. Straps are outfitted to accomodate many forms of fuel, from packs to flasks, and the zippered pocket on the outside of the pack is perfect for a key, ID, cash, and a phone (mine doubles as my MP3 player and it's nice to not have the earbud wires in my way or anything wrapped around my arm/waist).
My husband also pointed out that it is perfect to take on an outing to the zoo or museums, especially with children.
Lightweight, easy to fill, easy to clean. If 50oz is all you need, or you have an available re-fill source along the way, you really can't go wrong with the Hydrobak.
Best Uses
Comments about CamelBak Hydrobak Hydration Pack - 50 fl. oz.:
I bought this for use during my weekend cycling getaways which generally lasts for 2 hours. This is teh perfect capacity and very convinient to drink on the go. Also the nozzle design ensure no spillage. I even use this for my day trek, the best part is you can remove the pouch and use it in your REI packs
Good value for money
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Video Tutorials
Frequently Asked Questions
Trial Request
Additional Rendernodes
Video Tutorials
Exercise 1: "You're The Director"
Exercise 2: "Chorus Line"
Exercise 3: "Move it"
Exercise 4: "It's A Pitch"
Exercise 5: "Take A Walk"
Exercise 6: "The Door's Stuck"
Not yet available.
Exercise 7: "Can You Say That?"
Exercise 8: "Customized Car"
Exercise 9: "Flower Power"
Exercise 10: "FW-190 Fighter"
Exercise 11: "Giraffe"
Not yet available.
Exercise 12: "Lip Poses"
Exercise 13: "Show Some Backbone"
Exercise 14: "Playing Marble"
Exercise 15: "Eat My Dust"
Exercise 16: "Smoke Wind and Fire"
Not yet available.
Exercise 17: "Cosmic Bowling"
Exercise 18: "Waving The Flag"
Exercise 19: "Flying South"
Additional Exercise: Thom Constraint
Additional Exercise: Path Ease
Interesting Info: History of Animation
Additional Exercise: Walk Wheel


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Please, come 15 minutes before the class.
You will receive a confirmation email during the next 24 hrs.
Bring your voucher/coupon/receipt to the class. If you have any questions, please call us at 786.272.5412
Note: If you have a 2.5hs deal class (Living Social or Groupon), you can assist to the class, but you should pay $6 diference, because this is a 3hs. class.


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On the rise Norwich indiepunk band Fever Fever have a new single out now. It's available as a v limited edition pink cassette which you can order here after streaming above.
Posted 1 year ago
4 notes
Transgressive, Fever Fever, Kissability, The Chair, Norwich, Indie, Art-punk,
About Louder Than War


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Dianne (nee Reynolds) Thovson, 63, of Davenport, Iowa, went to be with the Lord on Saturday, Nov. 3. Visitation was held Nov. 7 at the Runge Mortuary.
Dianne was born on June 27, 1949, in Ashland, Ky., to James and Julianna Reynolds. She grew up in Silver Bay, a place she loved and remembered fondly. She graduated from Bethel College in 1971 and married Allan Thovson on Sept. 14, 1973. She and her family moved to Davenport in 1984.
Dianne's greatest joy in life was her family. She was a loving and supportive mother who enjoyed encouraging her children in their various activities. Whether it was cheering at baseball, football, soccer or volleyball games, helping with school projects and papers or just listening and giving hugs, she was there and always willing to help. Dianne loved the beach, and cherished special trips to Belleair Beach, Fla., Silver Bay and a special trip to Hawaii. She also enjoyed gardening, reading, and scrapbooking.
Dianne was thoughtful, generous, encouraging, and kind. She often sent special notes to those she loved or picked up the phone to offer support. She loved playing with all her grandchildren and bringing joy to others. She will be deeply missed.
Those left to honor her memory include her loving and devoted husband, Allan; her children and their families: Katie Thovson, Teresa Louw, Bailey Maberry (son, Tanner), Hannah Maberry (fiancé, Kyle Davis), Logan and Kyra Thovson; James and Katherine Thovson, Alexandra, Oliver, and Emmett Thovson; her brother, Roger Reynolds and his family; her loyal companion, Kobe; and a host of other extended family, including her parents-in-law, Sanford and Dorothy Thovson.
She was preceded in death by her parents.
In lieu of flowers, a memorial for her grandchildren's college fund will be established. Online condolences and tributes may be expressed at www.rungemortuary.com
Tags: obituaries


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- Musician's Friend Best Selection, Price & Service. Guaranteed.
Need Help? Ask our Experts or call 800-449-9128
Asistencia en Español 866-226-2919
Need Help? Ask our Experts or call 800-449-9128
An unusual and beautifully crafted instrument.
The 12-fret Mitchell MU70 Concert Ukulele has a spruce top, and rosewood back and sides. This sweet sounding ukulele is appointed with an abalone rosette and purfling. Case sold separately.
Order today.
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Eternal Sunshine Creations
Janis Wide Scoop Raglan Top
Started in 2009, Eternal Sunshine Creations is a unique collection of contemporary hand knits, crochet and sweaters blending bohemian California lifestyle with a effortless chic. Eternal Sunshine Creations explores these dichotomies through vintage-inspired, hand-knit pieces with a modern sensibility. A world traveler raised and educated in Tokyo, designer Naomi K. Sills launched Eternal Sunshine Creations after years spent working for a Japanese fashion retailer and finally settling down in Southern California. The breezy, forever-sunny SoCal lifestyle acts as her muse in this line of beautifully crocheted modern knitwear brimming with contrasts.
- 76% acrylic 24% nylon
- Dry clean only
- Styled with MINKPINK Slasher Flick Shorts in Denim.
- Styled with Jen's Pirate Booty Soaring Cuff in Gold.
- Styled with Jen's Pirate Booty New Mexico Cuff in Gold.
- Styled with House of Harlow Bone Wrapped Ring in Gold.
- Modeled in size S. See fit guide for model's dimensions.
- Revolve Style No. ESUN-WK19
- Manufacturer Style No. FW12D1


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Hang tight!
Recipe by Keri
"I make these chicken wings every year for my family on New Year's Eve and they go crazy for them! The cooking method is what makes them so fantastic."
Watch video tips and tricks
cooking spray
2 quarts vegetable oil for frying
5 pounds chicken wings, separated at joints, tips discarded
1 cup hot wing sauce
1 pound carrots, cut into sticks
6 ribs celery, cut into sticks
2 cups blue cheese salad dressing
* Percent Daily Values are based on a 2,000 calorie diet.
New Year's Eve Chicken Wings
Serving Size: 1/20 of a recipe Servings Per Recipe: 20 Amount Per Serving Calories: 308 Calories from Fat: 249
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Erik + Nicole's Wedding | Mount Gulian - Beacon, NY
Erik and Nicole are an adventurous, passionate Seattle couple who love daring hikes and nature photography. They've tackled tough mountain passes such as Mt. St. Helens, and through these challenges, Erik and Nicole forged their relationship amidst the rugged and mercurial Northwest terrain. In fact, Erik proposed to Nicole during one of their hikes! Their vision for the wedding was no different - they wanted to celebrate near Nicole's hometown close to the quaint town of Beacon in New York's bucolic Hudson Valley. Mount Gulian on the Hudson offered the perfect historic backdrop for all their creative, do-it-yourself details, including a hand-made altar canopy made by Nicole's father, banquet tables named according to the mountains they've climbed, and a wonderful ensemble of hand-made invitations and programs! This was seriously beautiful stuff!
The party continued through the night in the spectacle-lit barn, and I was able to sneak Erik and Nicole out for a few portraits. Simply gorgeous.
Be sure to follow Erik's excellent photography site here. Big thanks to Fred Lee Films for the wedding film as well!


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Tucker Glotzbach
May 24, 2012
The Sweetlife Food & Music festival was a lot of fun and an overall great experience. The headliners were the Shins, Kid Cudi, and Avicii. I was there from beginning to end, a total of about 11 hours. My first and maybe favorite performer I saw was Action Bronson, an underground rapper out of Brooklyn.... Read more »


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