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By Wendy Donahue Chicago Tribune
The American fashion industry held its breath on Inauguration Day for a series of Big Reveals.
Word came quickly that the navy check coat and dress Michelle Obama wore to the morning prayer service at St. John's church was from American designer Thom Browne's pre-fall 2013 collection.
"It struck me beforehand that she could wear Democratic blue," said Simon Collins, fashion dean at Parsons the New School for Design in New York, whose alumni include Jason Wu, who designed Obama's inauguration ball gowns this year and four years ago. "Previously, she might have wanted to be neutral, but now the way President Obama is asserting his Democratic values more than before, I thought perhaps blue would be a color she would wear."
The jacquard fabric of her inauguration morning dress and coat were based on a men's silk necktie, according to a White House aide. Browne is best known for the shrunken suit silhouette, with boyish high-water pants, that he introduced in menswear a few years ago.
As usual, the first lady mixed luxurious and accessible pieces. For the ceremonial swearing-in, Obama added a beaded J. Crew belt over the coat and switched out of J. Crew "Valentina" pumps into knee-high leather and suede Reed Krakoff boots.
Her magenta cashmere-lined leather gloves were J. Crew.
The first lady also wore a navy Reed Krakoff dress Sunday for the official swearing-in at the White House.
Any fears that the fashion world's focus had jumped the pond to the Duchess of Cambridge were allayed on Inauguration Day.
"The novelty has worn off. We're used to the fact the first lady is cool and very stylish - but it doesn't make her any less so," Collins said. "As interest in her fashion has waned in the reactionary media, reaction from the fashion industry has grown because there is a visible effect on business. She certainly can have an effect, it's not necessarily a guarantee of success. It's a common misconception that one outfit can build a business."
Chicago-based designer Maria Pinto, who Obama wore often during the first presidential campaign, shut down her business in Chicago in 2010, citing the economic downturn and retailers' shrinking inventories.
Jason Wu, meanwhile, has expanded his business since Obama wore his gown.
"My signature collection has had a lot of success," Wu said during a recent visit to Chicago. He just launched a contemporary collection, called Miss Wu, exclusively at Nordstrom stores and nordstrom.com. Miss Wu pieces range from $190 to $850, which is where his signature collection picks up. Although Miss Wu is for a younger customer, it retains the figure-flattering tailoring of the signature pieces that Obama has worn.
"With anything I do, I'm really in the business of dressing women," Wu said. "I don't want to create things that people can't wear."
Obama has championed that ideal in fashion, overthrowing the tyranny of the size 2 in a way that the former Kate Middleton does not with her super-slim frame.
"Michelle Obama represents, ironically, sort of ordinary women," said Hazel Clark, a professor in Parsons fashion studies program.
Parsons has trained other designers Obama has worn, including Prabal Gurung, Peter Som, Alexander Wang, Derek Lam and Narciso Rodriguez, whose red and black dress captured the spotlight when Obama wore it the night her husband was first elected president.
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Four-Chip Fudge Recipe
- 1-1/2 teaspoons plus 3/4 cup butter, divided
- 1 can (14 ounces) sweetened condensed milk
- 3 tablespoons 2% milk
- 1 package (12 ounces) semisweet chocolate chips
- 1 package (11-1/2 ounces) milk chocolate chips
- 1 package (10 ounces) peanut butter chips
- 1 cup butterscotch chips
- 1 jar (7 ounces) marshmallow creme
- 1/2 teaspoon almond extract
- 1/2 teaspoon vanilla extract
- 1 cup Diamond of California Chopped Walnuts
- Line a 13-in. x 9-in. pan with foil and grease the foil with 1-1/2 teaspoons of butter; set aside. In a large heavy saucepan, melt the remaining butter over low heat. Add the next six ingredients. Cook and stir constantly until smooth. (Mixture will first appear separated; continue stirring until fully blended). Remove from the heat; stir in the marshmallow creme and extracts until well blended. Stir in nuts.
- Spread into prepared pan. Refrigerate until set. Lift out of pan and remove foil; cut into squares. Store in the refrigerator. Yield: about 4-1/2 pounds.
Reviews for Four-Chip Fudge(6)
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I make these every year as they have become a Christmas tradition in my house. They are absolutely delicious and I do not change a thing!
Hands down the BEST fudge ever!!! I am "famous" for this fudge. I take it to my kids school and they LOVE it!! Super easy to make too! Sometimes I add a bag of butter brickle chips for fun.
This is the best fudge recipe I have found in along time. I work for a school system and take it to work and the principals and staff all love it.
I've made this fudge for at least 5 years if not 6-7 years! :) We love it!!!
We've made it every year since 2005. Made some for my family one year - my little brother found the tin and made off with it. lol No one else got any. Making some JUST for him this year. :) THANK YOU to whoever shared the recipe originally!
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DETROIT -- Detroit Red Wings fans filled Joe Louis Arena fired up to boo Ryan Suter andZach Parise.
When the game was over, the Red Wings gave their followers a reason to stand and cheer.
Henrik Zetterberg snapped a tie midway through the second period, and Todd Bertuzziscored his second goal of the game early in the third to lift Detroit to a 5-3 win over theMinnesota Wild on Friday night.
Suter was booed when he had the puck, and Parise was jeered after he scored his first goal. Both players have become unpopular in the Motor City because they turned down deals from Detroit to sign with Minnesota last summer.
"Of course, you heard them," Zetterberg said.
Detroit's new captain also heard a lot of sighs and groans early in the game from red-and-white clad fans when the Wild dominated play for much of the scoreless first period.
"They gave us what we deserved because we weren't playing well," Zetterberg said. "Fans are very engaged here; that's why this is a great place to play."
Detroit wanted to keep its depleted roster stacked with talent last July by making offers to Suter and Parise, the top two free agents, but both chose to play together in Minnesota with matching 13-year, $98-million contracts.
Parise, though, said the Red Wings were definitely one of the teams he was very interested in playing for this season.
"They're just a great organization. I have a lot of respect for them," Parise said. "They do things the right way. They play the game the right way. That was a tough one, because it's a really good place to play."
Pavel Datsyuk, who assisted on Zetterberg's goal, put Detroit ahead by two late in the second period. Datsyuk also set up Bertuzzi on his second goal that gave the Red Wings a 5-2 lead.
Parise's second goal of the game banked in off Zetterberg to pull the Wild within two midway through the third period.
Jimmy Howard made 23 saves for the Red Wings, who were outshot 11-6 in the first.
"Howard was good early when we struggled with the puck," Detroit coach Mike Babcock said
Minnesota's Josh Harding gave up four goals on 17 shots in the first two periods and finished with 22 saves.
The Red Wings scored two power-play goals in the second period after failing the first 17 times they had an advantage over their first three-plus games this season. Detroit's special teams breakthrough leaves the defending Stanley Cup champion Los Angeles Kings as the NHL's only team without a goal on the power play in the lockout-delayed season that started last weekend.


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home > New Arrivals > Patricia
Item #10386
Our customers can't stop raving about this all-time favorite sandal. Croslite™ material comfort, colors that complement any style, and a 2" wedge heel for a little lift. Perfect.
Crocs™ Patricia Details:
- 2" wedge heel for a little lift.
- Massage-pod footbed feels good.
- Croslite™ material for maximum lightweight cushioning.
- Croslite™ material straps for support.
- Lightweight, non-marking sole.
APMA Approved Member (the American Podiatric Medical Association) recognizes certain Crocs™ Work shoes with their seal of acceptance, approving the shoes for general podiatric conditions.
Women's Comfortable Sandals
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Disappointed in the Patricia Oyster
I have brown and black in the Patricia and they're great. This pair, however, isn't. The strap across the instep is too big. It's a good 3/4 in. to 1 in. away from the top of my foot. Sadly, I have to return them.
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Extremely Comfortable Shoes
These shoes are so comfortable and still look nice enough to wear to the office. I often have trouble with sandals because my feet are a little bit wide but don't have any issues with these. I have to walk a lot at work and love these, sooo comfortable.
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Love the Patricia
I love this shoe, on my 5th pair. Bring back the gray with black sole. You didn't have gray so went with the blue with lavender. Ok for summer but fall/winter? Remember we are in Hawaii.
I couldn't wear the Patricia because I have a high instep and the snap wouldn't stay snapped. I subsequently bought the Patricia II and absolutely love love love that shoe. So if you have a wide foot or high instep you might want to purchase the Patricia II.
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Posted: Jan 18, 2013 4:11 PM by Dave Hovde
Updated: Jan 18, 2013 4:37 PM
Surf will initially be around 10 feet Saturday morning then increase through the day peaking at 12 to 16 feet with some sets to 20 feet late Saturday through Sunday. This surf will be especially dangerous due to the power from the long period swells. Surf will begin to diminish on Monday and continue to decrease into Tuesday.
A high surf advisory remains in effect from 8 am Saturday to 9 pm Monday for the Central Coast.
High surf will cause dangerous rip currents on all beaches and that will pose a threat to all swimmers. in addition sneaker waves can inundate beaches and overtop jetties.
Always swim near a lifeguard if possible. stay out of the water if not a strong swimmer. do not climb across jetties and never turn your back to the ocean as sneaker waves could knock you into the water.
A high surf advisory means that high surf will affect beaches in the advisory area producing rip currents and localized beach erosion.
As for the inner waters swells are expected to be between 2 and 4 feet this holiday weekend. Although some of the swell energy will be blocked by the Channel Islands enough swell energy will be able to sneak into the Santa Barbara and San Pedro Channels and bring local high surf and a widespread high risk for rip currents starting Saturday afternoon and continuing through Monday.
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Powerful, 'unusual' quake strikes off California coast
No immediate reports of damage or injuries
Dec 14, 2012
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No immediate reports of damage or injuries
Dec 14, 2012
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In the meantime a powerful earthquake a few hours ago.
Hitting the Southern California coast and off the western coast of Mexico here six point three magnitude about 2:30 AM local time.
About 530 here on the East Coast that a 160 miles off the coast of San Diego here and local news reports say the folks in Long Beach and Newport Beach.
In Southern California they felt the shaking.
Doctor Johnny was -- size mileage is director of the western observatory department of earth and environmental sciences at Boston College -- good morning to you doctor.
-- -- some interesting things to our producers that the interest in thing about this earthquake is the location where it occurred.
How so that's were.
That's right -- all of the earthquake activity we've seen off -- Southern California.
Has -- on the continent itself.
This earthquake occurred in the rock where the Condit is dropped away and now we have purely Oceanic rock.
Very unusual for earthquakes in Southern California -- -- show folks the San Andreas Fault I think that's what a lot of people think about in California.
I just advance -- one if we could hear we'll show how it how it runs along the entire West Coast of California what you're saying sir.
It is that whether or not the onshore activity is related to the offshore activity can you make a connection -- Or not.
Well will be studying that we don't really know.
What we know is obviously the Pacific Ocean plate is moving relative to the North American plate.
The San Andreas in the other faults are the boundary.
Now all of the defamation is on the falter on either side of the fault.
The question for us is is their son did play defamation is taking place now in the Oceanic rock to the west of California.
Could that pose a threat of earthquakes or even Sanaa and does that help us -- better predict the next big one.
It could help us predict and the next big one if we see unusual depth formations offshore.
That also are associated with earthquakes.
So far I don't know of any unusual onshore earthquake activity or interest in thank you doctor doctor -- -- there at Boston colors there -- Newton Massachusetts.
No tsunami on this one.
Because this magnitude was not big enough to create one but the depth is interest in two.
Only about six miles which is relatively shallow sir thank -- calling you again doctor.
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British it-girl Alexa Chung has added another item to her enviable fashion resume with her latest stint as the face of Longchamp's utopic Spring/Summer...
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Where to Dine in Sintra Eating in Portugal is easy but eating great food is what we wanted. The choices given to us were...
Nina Ricci has teamed up with Ladurée to launch a delectable duo – a new fragrance and macaron flavour. We love a new perfume launch,...
La Moda Dubai is the authoritative online source for fashion, beauty and luxury catering specifically to the UAE and greater Middle East region. Established in 2010, La Moda Dubai was conceived to provide breaking fashion and lifestyle news as well as in-depth features that provoke the imagination of the fine living connoisseurs of the Arabian Gulf.
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Last week, citizens of the United States voted to select who they thought would best serve them as President of their country, as legislators for their states, and more. They filed into their polling places (many of them waiting for hours), and indicated their choices on a touch screen or by colouring in ovals on a response form. Each voter weighed up the multiple consequences of each option and, after careful consideration, reached a conclusion. Then, each individual's personal decisions were counted, and out of the chaos a winner emerged.
Animals make collective decisions, too. While non-human species typically don't vote to choose their leaders, they do vote for other more routine decisions, like where to live or where to forage. But they don't have voting machines or ballots to determine the group's consensus, so how do they do it?
Some do it through the wisdom of crowds. Near the end of spring or the beginning of summer, honey bee (Apis mellifera) colonies grow too large for their hives, so the group splits in two. The mother queen and half of the worker bees leave the hive to seek a new location, while the daughter queen and the remaining workers remain in place. Minutes later, the departed group identifies a temporary resting place on a nearby tree branch, and from there it surveys the local real estate. Several hundred scouts fan out in all directions in search of a suitable location for a new hive. On their return, each scout communicates the location of the space they found by performing a waggle dance in front of their hive mates.
Over the course of several days, the scouts may spend as much as sixteen hours dancing, each advocating for a possible location. As the days pass, consensus begins to emerge. It isn't entirely clear what makes scouts stop campaigning for less popular sites; they don't get voted out as if they were participating in some insect version of Dancing with the Stars. Some simply stop dancing, while others switch their choreography to endorse one of the more popular options.
Majority vote
What is clear, however, is that the "hive mind" can make complex decisions only because the work is distributed across multiple individuals. Thomas Seeley and Susannah Buhrman, who have studied decision making in swarms of honey bees write, "we have seen that there is no omniscient supervisory bee that compiles all the evaluations and selects the best site. Instead, it is the highly distributed process of friendly competition among the scout bees that identifies the best site. Hence the cognitive effort that each scout bee must make is evidently quite small relative to the information processing done by the entire swarm."
For honey bees, few individuals possess valuable information, which the rest of the group relies on. However, social species throughout the animal kingdom often have to make decisions without the aid of expert knowledge. Such is the case for Tonkean macaques (Macaca tonkeana), a group of fruit-loving monkeys that live in the forests of Sulawesi, Indonesia. Fruit trees are distributed randomly throughout the forest, with some areas containing more fruit than others. So Tonkean macaques must decide which direction they will move in search of food, and they make those choices by majority vote.
When a particular Tonkean macaque wishes to move the group, he or she walks a few steps in the desired direction, pauses, and then turns his or her head back towards the rest of the group. This indicates that the group should move to a new food patch. The other monkeys then decide whether to support the direction suggested, or whether to offer an alternative. If an alternate direction is proposed, each group member votes by joining with his or her favoured candidate. Like the leader himself, they walk a few steps, pause, and then turn their heads back to inspect the rest of the group.


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CHIPPENHAM TOWN: Griffin is the fans' favourite (From The Wiltshire Gazette and Herald)
Get involved! Send photos, video, news & views. Text WILTS GAZETTE to 80360 or email us
CHIPPENHAM TOWN: Griffin is the fans' favourite
2:00pm Friday 4th May 2012 in News
BLUEBIRDS frontman Alan Griffin was crowned supporters' player of the year for the second successive season after last weekend's final game of the season.
The Chippenham striker, who turned 29 on Sunday, has been the ever-present focal point of Adie Mings' attack this season and enjoyed a productive season in front of goal, with 24 strikes to his name.
Fellow hotshots Lewis Powell and Dave Gilroy were closest behind Griffin in the goal stakes, with 10 apiece under their belt.
Bluebirds hotshots (2011-2012 season goalscorers)
Alan Griffin: 24
Dave Gilroy, Lewis Powell: 10
Ross Stearn, Toby Osman: 5
Jack Pitcher: 3
Scott Lye, James Guthrie, Ben Wickens: 2
Nathan Rudge, Steve Casey, Alex Kite, Aaron Wilson: 1
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The Msi x58 platinum came today so I started assembling everything. I'm having an issue where I push the power button and the machine starts up for 3 seconds then shuts off. This repeats non-stop. here is a hardware list: msi x58 obv 1x3 kingston hyper antec ea650 earthwatts psu 8600gt apogee gt waterblock I have the wb on as tight as I can get it without it seeming too tight tight.. this is the first time Ive had to use the bracket and screws, usually I'm used to the springs and thumb screw type. I cleared cmos and checked all conections but I do not know what is wrong, any advice, solutions or other input would be highly appreciative. Thanks I just tried to move the pumps rpm plug to the cpu1 panel and it didn't solve the problem.
Try the ram in a different dimm slot. Take off the water cooling and put on the standard cooler to make sure that isn't the issue (not likely since it's only on for a moment.) Verify that everything is plugged in correctly.
I moved the ram to the black dimms from the blue dimms using one stick. When i use the black dimm it powers up but the blue leds on the mobo all go out. then it restarts again. i don't have a stock fan to test with :-( fack.
Would be useful to take a pic of your mobo and put it here, 'cause I believe no one in this forum use this board yet.
loosened block = same problem resat the block but not as tight = same problem took out video = same problem
all i have is a webcam, and in xp on this laptop it takes tiny 3.5x3.5 pics gonna try to clear cmos and see what happens. it has a clear cmos button on the rear i/o panel but ill still listen and do the battery too.
nope the antec has proper plugs so i didnt have to use any adapters.. i have the 8 pin snug into the 8 pin and the other one is snug as well.
took the battery out.. with the cmos battery out it stays powered on, doesnt reboot or power off.. im gonna wait and try with the battery real soon
If you tighten a block too much, the motherboard dies I have heard. Try without the hard drive or optical drives and see if you can get into the bios pressing delete. My first venture in X58 was a DOA Msi X58. I hope you won't have the same bad luck.
i didnt tighten it toooo tight, i got down to where the screw gave resistance and then added a half turn. i put the battery back in and it powered on and stayed on, this was with no usb mouse, ps/2 keyboard.. as soon as i restarted with kb/mouse it began looping on/off again
if i take battery out and put it back in and restart it'll stay on but without post.. once i manually restart it the pc will restart into the on/off loop. even with no ram in and nothing else plugged in it still does on/off loop.
its the sli version.. speaker is not hooked up.. will hoook up now.. for sake of trying to get it to post i disconnected all usb/hd audio heads.. i never use the speaker
okay! the default switch was set.. thanks for that diagram i was looking for that! I just put one ram stick in the 2nd black dimm and I am at the bios! I'm going to try 3 black dimms now. pray for me guys lol cpu temp says 26C (seems too low) ioh is 67c (wtf is IOH) system is 42c all voltages look great
3 black dimms is GOLDEN.... Not sure if everything is A-ok but I'm posting without beeps and getting to the bios on 3 ram sticks. ... stay tuned
LOL this pc smacks my old q9550 silly.. this is stock.. wow. Thank you everyone that pitched in and helped me troubleshoot this thing! I am grateful! Im loaded onto win 7 i had on the old q9550, gonna tinker around then do a fresh install soon.. but everything looks good thus far. Man, that would have sucked! if this thing died.. you have no idea how rocky the road to i7 has been.. getting rolled off [h] for my first board.. then this today.. phew... im glad its working at least. Thanks all


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Vorinostat and Isotretinoin in Treating Patients With High-Risk Refractory or Recurrent Neuroblastoma
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This phase I trial is studying the side effects and the best dose of vorinostat when given together with isotretinoin to see how well it works in treating patients with high-risk refractory or recurrent neuroblastoma. Vorinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Isotretinoin may help vorinostat work better by making tumor cells more sensitive to the drug. Giving vorinostat together with isotretinoin may be an effective treatment for neuroblastoma.
Condition | Intervention | Phase |
Disseminated Neuroblastoma Localized Unresectable Neuroblastoma Recurrent Neuroblastoma Regional Neuroblastoma Stage 4S Neuroblastoma |
Drug: vorinostat Drug: isotretinoin Other: diagnostic laboratory biomarker analysis Other: pharmacological study |
Phase 1 |
Study Type: | Interventional |
Study Design: | Endpoint Classification: Safety Study Intervention Model: Single Group Assignment Masking: Open Label Primary Purpose: Treatment |
Official Title: | Phase I Study of Vorinostat in Combination With 13-Cis-Retinoic Acid in Patients With Refractory/Recurrent Neuroblastoma. |
- Maximum tolerated dose (MTD) of vorinostat, determined according to incidence of DLT graded using NCI CTCAE version 4.0 [ Time Frame: 28 days ] [ Designated as safety issue: Yes ]
- Toxicity as assessed by NCI CTCAE v. 4.0 [ Time Frame: Up to 2 years ] [ Designated as safety issue: Yes ]All toxicities observed will be summarized in terms of type (organ affected or laboratory determination), severity (by NCI CTCAE), and attribution. Tables will be created to summarize theses toxicities and side effects by dose level and by course.
- Survival [ Time Frame: Up to 2 years ] [ Designated as safety issue: No ]
- Time-to-failure [ Time Frame: Up to 2 years ] [ Designated as safety issue: No ]
- Best response, assessed using RECIST [ Time Frame: Up to 2 years ] [ Designated as safety issue: No ]
Estimated Enrollment: | 54 |
Study Start Date: | December 2010 |
Estimated Primary Completion Date: | January 2014 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
Experimental: Treatment (isotretinoin and vorinostat)
Patients receive isotretinoin PO BID on days 1-14, PO suspension* of vorinostat QD on days 1-4 of course 1, and capsules of vorinostat PO QD on days 1-4 and 8-11 of course 2 and subsequent courses. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. EXPANSION COHORT 1 (=< 21 years of age): Once the MTD has been determined, patients are treated at that dose level as above. EXPANSION COHORT 2 (22-30 years of age): Patients receive isotretinoin as above and vorinostat at the MTD on days 1-3 and 8-10. |
Drug: vorinostat
Given PO
Other Names:
Drug: isotretinoin
Given PO
Other Names:
Other: diagnostic laboratory biomarker analysis
Correlative studies
Other: pharmacological study
Correlative studies
Other Name: pharmacological studies
Detailed Description:
I. To determine the maximum-tolerated dose of vorinostat in combination with isotretinoin in patients with high-risk refractory or recurrent neuroblastoma.
II. To define the toxicities of vorinostat administered in combination with cisRA.
I. To determine the pharmacokinetics of vorinostat given as a pediatric suspension.
II. To describe the relationship of vorinostat pharmacokinetics to the occurrence of systemic toxicity.
III. To determine the pharmacokinetics of cisRA given in combination with vorinostat.
IV. To describe histone acetylation levels in peripheral blood mononuclear cells after different doses of vorinostat.
V. To describe, within the context of a Phase I study, the response rate of vorinostat combined with cisRA in patients with recurrent/refractory neuroblastoma.
VI. To describe the toxicity and response rate of vorinostat at the determined maximal tolerated dose combined with cisRA in patients ages 22-30 years of age at study entry with recurrent/refractory neuroblastoma.
OUTLINE: This is a multicenter, dose-escalation study of vorinostat.
Patients receive isotretinoin orally (PO) twice daily (BID) on days 1-14, PO suspension* of vorinostat once daily (QD) on days 1-4 of course 1, and capsules of vorinostat PO QD on days 1-4 and 8-11 of course 2 and subsequent courses. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity.
EXPANSION COHORT 1 (=< 21 years of age): Once the maximum-tolerated dose (MTD) has been determined, patients are treated at that dose level as above.
EXPANSION COHORT 2 (22-30 years of age): Patients receive isotretinoin as above and vorinostat at the MTD on days 1-3 and 8-10.
Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity. Patients may undergo peripheral blood mononuclear cells collection for pharmacokinetics and histone acetylation studies.
After completion of study therapy, patients are followed up periodically.
NOTE: *Patients less than 10 years of age are encouraged to continue to use oral suspension beyond course 1.
Ages Eligible for Study: | up to 30 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Histologically confirmed high-risk neuroblastoma and/or demonstration of tumor cells in the bone marrow with increased urinary catecholamines meeting 1 of the following criteria:
Recurrent and/or progressive disease at any time
- Biopsy not required
Refractory disease (i.e., less than a partial response to front-line therapy, including a minimum of 4 courses of chemotherapy)
- Biopsy not required
Persistent disease by meta-iodobenzylguanidine (MIBG) scan, computed tomography (CT) and magnetic resonance imaging (MRI) scan, or bone marrow aspirates/biopsies after >= partial response to front-line therapy
- Histologic confirmation of viable neuroblastoma from at >= 1 residual site required
- Tumor seen on routine bone marrow morphology allowed
- Bone marrow immunocytology alone not allowed
- Patients in expansion cohorts 1 and 2 who have had a prior relapse are eligible with no measurable or evaluable sites of tumor (i.e., in second complete response)
Patient must have ≥ 1 of the following disease sites (excluding patients on the expansion cohort):
- Measurable tumor by MRI, CT scan, or X-ray
- MIBG scan with positive uptake at a minimum of 1 site
- Bone marrow with tumor cells seen on routine morphology of 1 bone marrow sample of a bilateral aspirate and/or biopsy
- Life expectancy >= 6 weeks
- Lansky performance status (PS) 50-100% (patients =< 16 years of age) OR Karnofsky PS 50-100% (patients > 16 years of age)
- Hemoglobin >= 8 g/dL (transfusion allowed)
Absolute neurtophil count (ANC) >= 750/μL
- ANC >= 500/μL for patients with marrow metastases
Platelet count >= 50,000/μL (transfusion independent)
- No platelet transfusions within 1 week
Serum creatinine based on age as follows:
- 0.8 mg/dL (=< 5 years of age)
- 1.0 mg/dL (> 5 and =< 10 years of age)
- 1.2 mg/dL (> 10 and =< 15 years of age)
- 1.5 mg/dL (> 15 years of age)
- Hematuria =< 1+ and/or proteinuria =< 1+
- Total bilirubin =< 1.5 times upper limit of normal (ULN)
- Alanine aminotransefrase (ALT) and aspartate aminotransferase (AST) < 3 times ULN
- Alkaline phosphatase =< 2.5 times ULN
- Serum triglycerides =< 300 mg/dL
- Serum calcium < grade 2
- Negative pregnancy test
- Not pregnant or nursing
- Fertile patients must use effective contraception
- Normal ejection fraction (>= 55%) by echocardiogram or radionuclide multi-gated acquisition (MUGA) OR normal fraction shortening (>= 27%) by echocardiogram
- QTc interval =< 450 msec
- No patients who, in the opinion of the investigator, may not be able to comply with the safety of study requirements
- No disease of any major organ system that would compromise the patient's ability to withstand therapy
No active or uncontrolled infection
- Patients on prolonged antifungal therapy allowed provided culture and biopsy are negative in suspected radiographic lesions
No allergic reactions to paraben preparations (i.e., Accutane, Sotret)
- Alternate preparations to paraben allowed
- Fully recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy
- At least 3 weeks since prior myelosuppressive chemotherapy, including cytotoxic agents given on a low-dose metronomic regimen
- At least 7 days since prior biologic anti-neoplastic agent (including retinoids) therapy
- At least 7 days or 3 half-lives, whichever is longer, since prior monoclonal antibodies
More than 2 weeks since prior radiotherapy (small-port)
- No prior radiotherapy in patients with 1 site of measurable or evaluable disease unless that site has demonstrated clear progression after completion of radiotherapy
- At least 12 weeks since prior large-field radiotherapy (i.e., total-body, craniospinal, whole abdominal, total lung, or > 50% of marrow space irradiation)
- At least 6 weeks since prior substantial bone marrow radiotherapy
At least 6 weeks since prior:
- Autologous stem cell infusion following myeloablative therapy
- Allogeneic stem cell transplantation without evidence of active graft-versus-host disease
- At least 6 weeks since prior 131I-meta-iodobenzylguanidine (MIBG) therapy
- At least 7 days since prior cytokines or hematopoietic growth factors
- More than 30 days since prior and no concurrent valproic acid
- More than 30 days since prior and no other concurrent investigational medications
No prior vorinostat combined with isotretinoin
- Prior vorinostat or isotretinoin single-agent or combined with alternative agents allowed
- No other concurrent anti-cancer agents including chemotherapy, radiotherapy, biologics, or immunomodulating agents
- No concurrent azole anti-fungal therapy
- No concurrent pentamidine therapy for pneumocystis pneumonia (PCP) prophylaxis
- No concurrent enzyme-inducing anti-convulsant therapy
United States, California | |
Children's Hospital Los Angeles | Recruiting |
Los Angeles, California, United States, 90027 | |
Contact: Araz Marachelian 323-361-8573 email@example.com | |
Principal Investigator: Araz Marachelian | |
New Approaches to Neuroblastoma Treatment (NANT) | Recruiting |
Los Angeles, California, United States, 90027-6016 | |
Contact: Julie R. Park 206-987-1947 firstname.lastname@example.com | |
Principal Investigator: Julie R. Park | |
Lucile Packard Children's Hospital Stanford University | Recruiting |
Palo Alto, California, United States, 94304 | |
Contact: Clare J. Twist 650-723-5535 email@example.com | |
Principal Investigator: Clare J. Twist | |
University of California San Francisco Medical Center-Parnassus | Recruiting |
San Francisco, California, United States, 94143 | |
Contact: Katherine K. Matthay 415-476-0603 firstname.lastname@example.com | |
Principal Investigator: Katherine K. Matthay | |
United States, Colorado | |
Children's Hospital Colorado | Recruiting |
Aurora, Colorado, United States, 80045 | |
Contact: Margaret E. Macy 720-777-8866 email@example.com | |
Principal Investigator: Margaret E. Macy | |
United States, Georgia | |
Children's Healthcare of Atlanta - Egleston | Recruiting |
Atlanta, Georgia, United States, 30322 | |
Contact: Kelly C. Goldsmith 404-727-2655 firstname.lastname@example.com | |
Principal Investigator: Kelly C. Goldsmith | |
United States, Illinois | |
University of Chicago Comer Children's Hospital | Recruiting |
Chicago, Illinois, United States, 60637 | |
Contact: Susan L. Cohn 773-702-2571 email@example.com | |
Principal Investigator: Susan L. Cohn | |
United States, Massachusetts | |
Children's Hospital Boston | Recruiting |
Boston, Massachusetts, United States, 02115 | |
Contact: Suzanne Shusterman 617-632-4901 firstname.lastname@example.com | |
Principal Investigator: Suzanne Shusterman | |
United States, Michigan | |
C S Mott Children's Hospital | Recruiting |
Ann Arbor, Michigan, United States, 48109 | |
Contact: Gregory A. Yanik 734-746-3243 firstname.lastname@example.com | |
Principal Investigator: Gregory A. Yanik | |
United States, North Carolina | |
Duke University Medical Center | Recruiting |
Durham, North Carolina, United States, 27710 | |
Contact: Susan G. Kreissman 919-684-3401 firstname.lastname@example.com | |
Principal Investigator: Susan G. Kreissman | |
United States, Ohio | |
Cincinnati Children's Hospital Medical Center | Recruiting |
Cincinnati, Ohio, United States, 45229 | |
Contact: Brian D. Weiss 513-636-9863 email@example.com | |
Principal Investigator: Brian D. Weiss | |
United States, Pennsylvania | |
Children's Hospital of Philadelphia | Recruiting |
Philadelphia, Pennsylvania, United States, 19104 | |
Contact: Yael P. Mosse 215-590-0965 firstname.lastname@example.com | |
Principal Investigator: Yael P. Mosse | |
United States, Texas | |
Cook Children's Medical Center | Not yet recruiting |
Fort Worth, Texas, United States, 76104 | |
Contact: Mary Meaghan P. Granger 682-885-4007 firstname.lastname@example.com | |
Principal Investigator: Mary Meaghan P. Granger | |
United States, Washington | |
Seattle Children's Hospital | Recruiting |
Seattle, Washington, United States, 98105 | |
Contact: Julie R. Park 206-987-1947 firstname.lastname@example.com | |
Principal Investigator: Julie R. Park | |
Canada, Ontario | |
Hospital for Sick Children | Recruiting |
Toronto, Ontario, Canada, M5G 1X8 | |
Contact: Sylvain Baruchel 416-813-7795 email@example.com | |
Principal Investigator: Sylvain Baruchel |
Principal Investigator: | Julie Park | New Approaches to Neuroblastoma Treatment (NANT) |
No publications provided
Responsible Party: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT01208454 History of Changes |
Other Study ID Numbers: | NCI-2011-02522, NCI-2011-02522, CDR0000683405, NANT-N2008-02, N2008-02, N2008-02, P01CA081403 |
Study First Received: | September 23, 2010 |
Last Updated: | August 26, 2013 |
Health Authority: | United States: Food and Drug Administration |
Additional relevant MeSH terms:
Neuroblastoma Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumors, Primitive Neoplasms, Neuroepithelial Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal Neoplasms by Histologic Type Neoplasms Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue |
Isotretinoin Vorinostat Dermatologic Agents Therapeutic Uses Pharmacologic Actions Histone Deacetylase Inhibitors Enzyme Inhibitors Molecular Mechanisms of Pharmacological Action Antineoplastic Agents |
ClinicalTrials.gov processed this record on December 11, 2013


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Patterson-UTI Energy, Inc. Announces Earnings Conference Call and Webcast
Thursday, February 7, 2013 at 9:00 a.m. Central Time
HOUSTON, Dec. 20, 2012 /PRNewswire/ -- Patterson-UTI Energy, Inc. (NASDAQ: PTEN) will hold its conference call to discuss results for the fourth quarter ending December 31, 2012 on Thursday, February 7, 2013 at 9:00 a.m. Central Time.
Participants can access the call by dialing (866) 362-4666 or (617) 597-5313 with the access code 48970041. The call will also be webcast and can be accessed through a link in the Investors section of the Company's website at www.patenergy.com. The webcast is also being distributed over the Thomson Reuters Investor Distribution Network to both institutional and individual investors. Individual investors can listen to the call through Thomson Reuters' individual investor center at www.fulldisclosure.com. Institutional investors can access the call via Thomson Reuters' password-protected event management site, StreetEvents (www.streetevents.com). Webcast participants should go to one of the web addresses above 10-15 minutes prior to the scheduled start time. Replay of the conference call webcast will be available at these sites through Thursday, February 21, 2013.
Patterson-UTI Energy, Inc. subsidiaries provide onshore contract drilling and pressure pumping services to exploration and production companies in North America. Patterson-UTI Drilling Company LLC has more than 300 marketable land-based drilling rigs and operates primarily in oil and natural gas producing regions of Texas, New Mexico, Oklahoma, Kansas, Arkansas, Louisiana, Mississippi, Colorado, Utah, Wyoming, Montana, North Dakota, Pennsylvania, West Virginia, Ohio, Michigan, Alaska and western Canada. Universal Pressure Pumping, Inc. and Universal Well Services, Inc. provide pressure pumping services primarily in Texas and the Appalachian region.
Mike Drickamer, Director, Investor Relations
281.765.7170, firstname.lastname@example.com
SOURCE Patterson-UTI Energy, Inc.
More by this Source
Patterson-UTI Energy Announces Fourth Quarter Earnings Conference Call and Webcast
Dec 05, 2013, 06:00 ET
Patterson-UTI Reports Drilling Activity for November 2013
Dec 03, 2013, 06:50 ET
Patterson-UTI Energy to Present at the Capital One Securities 8th Annual Energy Conference
Dec 02, 2013, 06:00 ET
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An audience member at one of Emmons' numerous dance performances likely would not see that in the Paducah Tilghman High School senior. It's kind of a contradiction, she said, but dance has helped her come out of her shell over the past 16 years.
Dance has taken her across the country for competitions. She recently performed in California, where she also learned about Chapman University, one of two front runners for college. Emmons began dancing competitively when she was 7. It was a serious commitment to make as a second-grader, but dance won out over competitive soccer.
Sarah Emmons, daughter of Keith and Lisa Emmons, is the Mid-Continent University Teen of the Week. Each Monday, the Sun features a different MCU Teen of the Week selected from nominees who high school guidance counselors throughout western Kentucky and southern Illinois submit to the Sun. Mid-Continent University will provide each Teen of the Week with a $2,500 annual scholarship to its university, which is renewable for four years. In the spring, a Teen of the Year will be chosen from the weekly winners and will receive a full four-year scholarship to Mid-Continent University, currently valued at up to $55,000, or a cash reward of $2,500 paid through the Paducah Sun if the student selects another college to attend.
Her favorite dance style is contemporary. Ballet is more set, she said. With contemporary dance, the artist can explore new movement, new choreography and new interpretations. Emmons wants to study both dance and dietetics during college, and she hopes to join a professional company after she finishes her degree.
Emmons' academic schedule has kept her busy through high school. With numerous Advanced Placement classes, she balances her time wisely. She'll continue that focus in college to complete her double major. Positive encouragement from her family and her dance coaches has helped keep her motivated. One of Emmons' dance teacher got her interested in dietetics because it's such a pertinent piece of the performance equation.
"As a dancer, your body is your instrument," Emmons said. "Like in all other things, you want to keep your instrument fine tuned."
When she's not practicing or studying, Emmons likes to spend time with her friends. She also finds solace in playing piano. Though she doesn't consider herself a virtuoso, she said it's a relaxing practice that also helps her interpret dance.
Call Rebecca Feldhaus, a Paducah Sun staff writer, at 270-575-8651.


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Thursday, Dec. 19, 2013 | 8:59 p.m.
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Posted: 8:03 p.m. Sunday, Dec. 30, 2012
By Jay Morrison
Staff Writer
With four sacks against Baltimore, the Cincinnati Bengals set the single-season franchise record with 51 but finished one behind Denver for the NFL lead.
"It's great," said Carlos Dunlap, who had one sack Sunday to bring his season total to six and also had his first career interception, which he returned 14 yards for a touchdown.
"I was fortunate enough to get the rookie record (9.5 in 2010), and now I'm a part of the team sack record," Dunlap added. "It's great to be a part of that. It just shows the ability we have on this team. We've got two guys over 10 sacks, and our backups are at (six). It's a pretty good year for us."
Michael Johnson had two sacks against the Ravens to give him 11.5 this year. He joins Geno Atkins (12.5) as the first Bengals duo to record double-digit sacks in the same season since Reggie Williams (11) and Eddie Edwards (10) in 1981.
Wallace Gilberry had the other sack Sunday, his sixth of the season.
Marvin's milestone
Rookie wide receiver Marvin Jones scored his first NFL touchdown Sunday on an 11-yard pass from Andy Dalton that tied the score at 7-7 with 39 seconds left before halftime.
"It's a great feeling," said Jones, who also tied his career high with five catches and finished with 45 yards.
Jones caught the pass over the middle at the 6-yard line and spun away from two defenders to race into the end zone.
"From my peripheral vision and the play design, I knew they were there," Jones said "I was able to use that and turn right away from them."
Jones, who has started the last five games after fellow rookie Mohamed Sanu suffered a season-ending stress fracture, has a combined 10 catches for 110 yards the last two weeks.
Green-Ellis scratched
Bengals running back BenJarvus Green-Ellis was a late scratch after suffering a hamstring injury during pregame warm-ups.
"I don't know how severe it is," Bengals head coach Marvin Lewis said. "He just didn't feel right in warm-ups today, so we held him out. He was a little tight."
Green-Ellis finished the regular season with 278 rushes for a career-high 1,094 yards and six touchdowns.
Foot feat
Punter Kevin Huber set the Bengals' single-season records for gross and net average with Sunday's performance.
Huber punted seven times for a 47.1 average, raising his season total to 46.6 and breaking the previous mark of 46.2 set by Dave Lewis in 1970. His net average against the Ravens was 43.4, upping his season total to 42.0, breaking the record of 39.3 set by Dale Livingston in the inaugural Bengals season of 1968.
Huber also had four punts downed inside the 20 Sunday, giving him 33 for the season. Two of his kicks against the Ravens were downed inside the 5, giving him 12 this season.
Quick hitters
Chris Crocker left the game with a quad injury but said "no worries at all" when asked about playing next week in the Wild Card game. … Nate Clements started for the injured Terence Newman (groin) at cornerback, his first start since Nov. 18 at Kansas City. Clements had played just 17 defensive snaps in the past five games. … Marvin Lewis became the first Bengals coach in history to have three 10-win seasons (11-5 in 2005, 10-6 in 2009, 10-6 this year). … The Bengals won seven of their final eight games for the third time in franchise history (1970 and 1981 are the others).
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Improvements needed for start of season (From Watford Observer)
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Mordt blames Saracens' 7s disappointment on 'silly errors'
12:41pm Monday 6th August 2012 in News
Nils Mordt admits that Saracens will have to improve their basic skills by the London Double Header – the traditional Aviva Premiership season-opener – if they are to beat London Irish at Twickenham on September 1.
For the first time in the history of the J.P. Morgan Asset Management Premiership Rugby 7s Series, Saracens did not reach the finals – a failure Mordt blames on their inability to hold on to the ball.
While he was left frustrated at missing out at the Rec, Mordt is already looking towards the new season where he is desperate to force his way into Mark McCall's plans.
He said: "I can't wait for the season to get started. We have a warm-up game against Bedford and it will be good to put a marker down for the 15-man format in that and then I want to kick on for selection in that first game of the Aviva Premiership season against Irish.
"All the guys who have played in Bath have to put themselves in a good position and hopefully they will get opportunities this year.
"The best thing about Saracens is that everybody is dying for a spot. At the end of the day we all know it's a team sport and we will all be used over the season but it doesn't stop us from competing for a spot every single week.
"We coughed up the ball too often and made silly errors at the wrong time at the 7s but it's all easily rectifiable and the boys worked really hard and I am very proud of them."
Sarries skipper at the J.P Morgan Premiership 7s; Mordt faces a huge battle to break into the first team for the showpiece opener, with competition from the likes of Owen Farrell and Charlie Hodgson for the number ten jersey.
But regardless of who gets the nod, World Cup winner Will Greenwood is confident Sarries will get past the Exiles and kick off their campaign in better style than a year ago when they were shocked by Wasps.
Greenwood said: "Despite how they have done in the 7s I think London Irish will be beaten by Saracens.
"The London Double Header is a great day out at the start of the Aviva Premiership season.
"We saw that it put Sarries on the back foot last season when they lost to Wasps. We thought Wasps were going to come with a bit of a charge but then look what happened to those guys.
"Rugby in the Premiership is getting bigger and better in terms of the brand of rugby being played and I'm really looking forward to the start if the season.
"If the London Double Header is your home game and you win it, the people who have lost away from home say 'well done', but we won't worry.
"But if that's your away game and you can clean up there then the opposition still have to come back to yours and it gives you an advantage."
For all the latest news and results from the final round of the J.P Morgan Premiership Rugby 7s Series, visit www.jpmorgan7s.com.
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Take the college student survey to share your opinions about your school and be entered into a $1,000 scholarship!
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B A+F Campus Resources: Recently upgraded iMacs and a very fast internet connection. Software updates tend to run about 1-2 years behind the state of the art.
C A+F Student Body: Mostly military. As a veteran myself it'd be nice to experience a different group of people. A lot of jobless students just living off the GI Bill. Nothing wrong with that, but there seems to be a general malaise to the place.
B A+F Academic Flexibility: Generally pretty flexible. A lot of power rests with the teachers for individual decisions, such as taking a few days off for a life event.
C A+F Campus Resources: Very small class sizes and nearly all teachers have respectable industry experience. Poor facilities and location are a real drain for long term enrollment here.
B+ A+F Campus Resources: Can always count on the professor's as well as assistants to give you information on any thing you need as well as administration and financial aid
A- A+F Academic Experience: The fact that all the class I am currently taking are relevant to my career choice and doesn't deviate too much you are faced with shirt deadlines at times but with the design industry these deadlines are more than generous
A A+F Student Body: Every one is very respectful and can be a great place to network
A A+F Campus Resources: It's a very small campus, so you won't find many resources as you would with a typical college campus, but they do have enough to keep you comfortable. There are plenty of patio chairs and tables around for students to sit around in, the library is small, but cozy, and there are plenty of convenience stores around within walking distance.
A A+F Student Body: The typical student is someone who's just graduated from high school, or has some college credit under their belt. It's a very open-minded and diverse community; there are definitely different kinds of personalities at my school, and everybody respects one another.
A A+F Tuition & Financial Aid: Though I've had little experience talking with my school's Financial Aid, from my few encounters with them, they were very informative and helpful with my general questions, and they wanted to make sure I understood everything.
A A+F Academic Experience: I am only in my graphic design portion of the school but I am loving every class so far you have to learn a lot but is very entertaining at the same time teachers are very helpful and are always there when you need them up to date equipment.
A+ A+F Academic Flexibility: 3 choices of class schedules and will remain that way unless you choose to change very easy to address problems with administration
A- A+F Tuition & Financial Aid: I will be taking out all federal loans school was very straightforward helpful and pointed you to the right direction.
A A+F Academic Experience: I am currently in the graphic design part of my major and I have learned alot of great things which I will use in everyday design.
A A+F Academic Experience: I really like what they offer as in terms to classes. I would like them to add a particle class but all in all, a wonderful school.
A A+F Overall Experience: I really like my school. I feel very comfortable here and feel that I am valued as a student and have accessibility to computers and teachers if I have a question or if I need to finish up an assignment.
A+ A+F Academic Experience: Proffessors Are Extremely Involved – The teachers take the time to walk around and individually help students.
A+ A+F Overall Experience: I love Platt Art College, and the faculty members. The school loves to take field trips
A+ A+F Academic Experience: Classes Are Awsome – The Teachers at my school really care about the education of a specific Major.
B A+F Student Body: The are about 350 students at once that attend Platt College San Diego. Everyone is serious about there work, and therefore it is not your average university type. The majority of people range from 25-35 years old.
Online Courses: Classes Not Offered Online – Classes are in class only. There is no classes offered online.
A- A+F Overall Experience: Excellent School – Platt College San Diego is an exciting and excellent school. It is a very small school, which works perfectly for me. There is allot of hands on experience, and due to the small class sizes it is easy to get the professors help when needed, unlike many traditional universities. Overall, it has been a great experience so far.
A+ A+F Career Services: we have portfolio classes that help us make our own resume and put our work in a journal that is given to us by the school. Where then we can show at a job interview and know what to do
A+ A+F Academic Experience: you work hand on in your major and you understand what you are working on. They offer tutoring and one on one with the teacher or teachers assistant.
A+ A+F Campus Resources: Social Scene – we do holiday events at school that everyone participates and everyone is getting along with one another
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On the landmark November 9th episode of The Oprah Winfrey Show, Oprah sat down with Former President George W. Bush as well as his parents Barbara and Former President George H. W. Bush. Both Mrs. Bush and her son have current memoirs out covering their lives and time in politics and/or the public eye.
Buy Decision Points by George W. Bush from Amazon for the Kindle or from Barnes and Noble for the Nook.
Buy Barbara Bush by Barbara Bush from Amazon for the Kindle.


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Vt. police: 'suspicious letter' at US rep officeApril 29,2013BURLINGTON - The Burlington office of Vermont's lone congressman has been evacuated because of a suspicious letter.
Burlington Police Chief Michael Schirling says the letter sent to the office of U.S. Rep. Peter Welch drew the attention of the person who was processing the mail and police agreed it appeared suspicious.
A hazardous materials team is now investigating the package. Schirling says no threats came in associated with the package.
Welch, a Democrat, is on an overseas trip.MORE IN This Just InHARTFORD — Loose chickens created a traffic hazard on the interstate Tuesday morning. Full StoryCONCORD, N.H. Full StoryMEMPHIS, Tenn. Full Story -
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letters to the editor
Thank you so much to the 110 people who came to our opening exhibition and sale on Saturday at the Ridgway Library.
On behalf of the Moab community, the Moab Free Health Clinic would like to extend its thanks to the Telluride AIDS Benefit and the Telluride community for underwriting the cost of Rapid HIV and STD...
I wanted to let Norwood and surrounding communities know that I will be offering yoga classes at ACE starting October 1.
Due to the diligence of the Town of Telluride we are all becoming much more BEAR AWARE!
I'm writing to express my concerns regarding the current debate spurred by the Downtown Streetscape ballot initiative.
Everyone at Telluride Adaptive Sports Program would like to thank our loyal and generous supporters who came out to support TASP at the 15th Annual Bob Miller Memorial Golf Classic.
Congratulations and commendations to Matt Janowiak, U.S. Forest Service Columbine District Ranger, who is being proactive in protecting 70 acres in the Cascade Creek area North of Durango Mountain ...
With all of the gloom and depression in the news these days, it is easy to write off segments of our population, even here in 'Paradise."
I first found myself questioning the judgment of a newspaper editor who, having had a reporter in attendance at that meeting, would allow such an inaccurate and misleading account of what actually ...


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First Apartment Essentials for Adults - Gifts for the Hipster
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Certified Chef Dining Guide Submission Form
The ACF Certified Chef Dining Guide is a great opportunity to showcase your restaurant to the dining public looking for a special experience when visiting your area. More and more diners are turning to their smart phones for a quick list of restaurant options and the ACF Dining Guide offers restaurant options featuring an ACF certified chef.
This guide is a benefit to all ACF certified chefs at the Chef de Cuisine level or higher. Simply complete and submit the form below. Your listing is complimentary and will include your restaurant name, address, phone, type of cuisine, average meal cost, website and of course, the name of the ACF certified chef.


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I`ve read in couple of places that the name is "Allegra", but may be that is its local name
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Posted 16 February 2005 - 11:12 AM
I`ve read in couple of places that the name is "Allegra", but may be that is its local name
Posted 16 February 2005 - 12:11 PM
Impossible to say.
Do you feel your page is the best it can be for your users? (The on-the page stuff.) Would changing it make it worse or better (again for your users).
If you see changes you could make that you feel might enhance your search rankings, that will also enhance your users experience, then it certainly never hurts to make them.
If by changing anything it will do the opposite, then it may not be as good of an idea.
Posted 16 February 2005 - 12:24 PM
If by changing anything it will do the opposite, then it may not be as good of an idea.
Well lets put this way if I change I am quite sure I will get higher ranking for this new update but if google would decide to go back to the one before update I would get less ranking than before.
My users would not get that affected, I would just do some minor changes. This site is to "honest" thats why I need to work on it little. My other sites have really gone up where I didnt think I had a chance. None of them are spammy sites but they have been tweaked for better ranking and this affected site was just done for the usability which worked fine. But if nobody can see it then maybe I have to sacrife little from the usability.
The only thing is if this will be lasting or will it go back to the oldway then I would just leave as it is.
Posted 16 February 2005 - 12:27 PM
What makes you so sure your changes will make a difference?
Posted 16 February 2005 - 03:17 PM
What makes you so sure your changes will make a difference?
Of course I am not 100% sure it will go up I presume it will go up. My other sites has gone up and I have one site I only use for testing purposes and I succeeded on that one.
What I noticed is that except the links from outside internal linking inside the site seems to be little more important now.
On my test site I just put some important keywords and linked to the first page and as soon as Google saw that its ranking went up. This is one of the examples and of course maybe I am completely wrong. I could maybe change to the old one later on but I am not sure if I would get penalty for this, so i was not planning over exagerating just "help" google to see the important keywords. But if this is considered spamming I will not do it.
Posted 16 February 2005 - 05:28 PM
It's a shame that Google is currently rewarding such spammy behaviour, but hopefully they'll tweak and see the error of their ways.
Posted 16 February 2005 - 06:50 PM
If that's what you think will help, then by all means, you should go for it. Even if you don't think it would help, you should still go for it, because it sounds like it would also help your visitors. Remember, anything that helps your visitors can't be bad for the search engines.
They don't penalize you for helping your visitors. That's one thing we know for sure!
Posted 16 February 2005 - 06:51 PM
How do you know it's not helpful to the user? Do you have a general example? (Not a real site.)
Posted 17 February 2005 - 11:14 AM
Posted 18 February 2005 - 10:39 PM
The site isn't even in the first 700 results now. MY site's portfolio page linking to that site shows up, but not my client's site. If I do an allinurl, the site comes up, so I don't think I've been banned.
All I've been doing in the last few weeks is adding fresh content (he's a busy actor). To the best of my knowledge I haven't used ANY black hat SEO techniques.
My sister said she noticed the site was gone a few days ago (why she didn't let me know, I don't know...), so it's not even like it's a blip on a particular day.
I mean, this is his Official Website, and it's nowhere to be found.
I'm afraid to do anything, for fear of incurring Google's wrath. Any thoughts? I have a bunch of sites I'm designing and optimizing--two that I'm getting ready to launch, and I'd sure like to know if I'm doing something wrong
Edited by Jill, 18 February 2005 - 10:50 PM.
Posted 18 February 2005 - 10:52 PM
As to why the site doesn't show up, that's more concerning. Is some other site using your same content? Have you made recent design changes that could impede the site's spiderability? Have you changed servers, and perhaps there's a misconfiguration? Is your robots.txt file excluding the bots by mistake?
Posted 18 February 2005 - 11:27 PM
Posted 19 February 2005 - 09:07 AM
Part of the problem is that you're going to be competing against some pretty authoritative sites, even though yours is the Official site. You're up against sites like Yahoo! Movies and Biz, NPR (looks like he was a guest at some time), IMDb, NetFlix, etc. Those sites all have a lot of built-in in authority.
Ranking the Official site below these may not make a lot of sense, but that's probably going to happen unless some of these very authoritative sites also link to Patrick's official site.
I wonder though if these recent moves might also be related to thing that some have mentioned about Blog sites being de-valued in the normal serps? I didn't see any blog footprints on the main page, but maybe Google has decided to extend that to anything they deem to be a "personal" site? Hard to say. I've certainly not researched it at all, so that's just a off-the-top-of-my-head question.
The only cure I can think of for the short term would be to get some of these other very authoritative sites linking to his site. It is his Official web site after all. That should be enough to get their attention I would think. And it certainly wouldn't cause any harm.
Posted 19 February 2005 - 10:12 AM
There's nothing inherently wrong with the site, so I'm at a loss. Randy's suggestion of seeing if you can get the other fan sites to link to this official one may certainly help.
Hopefully, it's just a temporary glitch.
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the Mysterious Order of the Skeleton Suit investigates Hindi cinema
To my knowledge, there are very few skeleton suits to be found in Bollywood. I can think of only three: Pran and some of his friends in Karz,
one of the countless low-budget monsters in Shaitani Dracula, a movie so bizarre and terrible that you kind of have to see it to believe it, or if you are concerned for your mental well-being just read all about on Teleport City because therein Keith delivers one of the funniest pieces of writing of the decade,
and the jiving crew in the superb "Main Bhookha" from Bhoot Bungla, which Memsaab has written up with her usual aplomb.
However, given my love for villain lairs and 70s and early 80s masala (and its descendants), I have seen many skeletons and skulls as prominent decor or visual motifs.
the original Jaani Dushman |
Teesri Aankh |
Mr. India (both above) |
Sheshnaag |
Ajooba (look on the wall of rocks for two skeletons and the big stone skull) |
I also like these computer-generated skeletons in Naag Lok. They rise out of graves, bounce up and down (maybe they were backup dancers back in their day?), and whoosh towards the camera.
By leaps and bounds, the most enjoyable Bollywood skeleton I have ever seen is in Jaani Dushman: Ek Anokhi Kahani. I mean, look:
Is that not amazing? It has SLEEVES. For a video clip, click here. And if you've never seen this film, I would actually recommend reading my friend Steve's writeup of it (you remember Steve—he wrote Army of Monkeys) instead because the film is dreadful.
What skeletons have you found hidden in the dark recesses of the filmi world? Share in the comments!


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Open Houses and School Tours
We invite you to visit our school. Walk through our halls and get a sense of GHA. Meet our teachers, parents and students, and discover if GHA would be a good fit for your child and your family.
In addition to our one-on-one visits, you are also invited to attend an Open House. Let us show you our warmth, our engaged students and our wonderful faculty. Come talk with our students, faculty, administration, and parents.
Open house dates are:
Sunday, December 15, 2013 10:00 a.m. - 12:00 p.m.
If you cannot attend one of our open house dates, please fill out the form below or contact Bonnie Cook, Director of Admissions at 678.298.5377 or email@example.com for more information or to arrange a private tour.
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good article
can't wait to go next month
You can view the page at http://www.mustang.org/content.php/4...Vince-Johnson!
good article
can't wait to go next month
2013 School Bus Yellow Boss 302
1993 Red Cobra
Previous Stable: 2012 White Mustang GT - Traded
2004 Competition Orange Cobra - Sold, 2003 Black Cobra -Traded, 1998 Black Cobra -Traded
1991 White 5.0 Conv-Sold, 1986 Purple 5.0 Trunk-Sold
Thanks for the article. I plan to go to their racing school in the not too distant future.


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TLC Antiques is proud to be the 2nd largest Fenton Gold Showcase Dealer in the country! We're working our way to #1 THANKS to all of you! Depression Glass customers.... GREAT NEWS!!! The new Depression Glass Price Guide by Barbara & Jim Mauzy is finally here! Check out our contributions to this edition of their well known price guide! Look for us under Adam, Cherry Blossom,Cameo,Open Lace, Pillar Optic, Tea Room & Sierra to name a few! Barbara is wonderful to work with and we were honored to be included. Their book is filled with the latest finds and news on your favorite patterns, up to date values, as well as details to help you know how to tell the reproduction from the real thing! I highly recommend her book!
Black Friday Special We want to help you save for the Holidays! So beginning Black Friday were giving 20% off orders totaling $40 or more. Enjoy your favorite Depression Patterns, dress your table with Elegant Glass, give Fenton from today & yesterday! Sale ends 12/22/13 Use Coupon Code 12-2005 Use coupon code 12-2005 when ordering for 20% off when your order is over $40.00.
TLC Antiques Contact us! 1212 Queen StreetPottstown, PA 19464United States Updated Friday, December 13 2013©1995-2013 TIAS.com All rights reserved.


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Discontinuation of legacy email and calendar services
What Happened to Webmail?
As of Feb 1, 2012 the services of webmail.willamette.edu have been shut off. University email is being serviced by Google Apps For Education
I'm getting an error from my email program/phone/other device
It is possible that an email program (Thunderbird, Outlook, Mac Mail) or mobile device mail (iPhone, Android, Blackberry) still held settings allowing it to connect to our old mail servers. As of Feb 1, 2012 those connections are broken.
- If you are receiving error messages regarding an inability to connect to 'mail.willamette.edu' please contact the WITS Help Desk or your designated User Services Consultant. We can help diagnose which settings may be causing the problem.
Webmail was my homepage.
The webmail.willamette.edu page has been taken offline . If this page has been set as your browser's 'Home Page', we recommend you change this setting to another page of your choice.
- Help for changing the home page setting in various internet browsers


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Aviation Security:
Progress Since September 11, 2001, and the Challenges Ahead
GAO-03-1150T, Sep 9, 2003
Additional Materials:
- Highlights Page:
- Accessible Text:
(202) 512-4803
Office of Public Affairs
(202) 512-4800
In the 2 years since the terrorist attacks of September 11, 2001, the security of our nation's civil aviation system has assumed renewed urgency, and efforts to strengthen aviation security have received a great deal of congressional attention. On November 19, 2001, the Congress enacted the Aviation and Transportation Security Act (ATSA), which created the Transportation Security Administration (TSA) within the Department of Transportation (DOT) and defined its primary responsibility as ensuring security in aviation as well as in other modes of transportation. The Homeland Security Act, passed on November 25, 2002, transferred TSA to the new Department of Homeland Security, which assumed overall responsibility for aviation security. GAO was asked to describe the progress that has been made since September 11 to strengthen aviation security, the potential vulnerabilities that remain, and the longer-term management and organizational challenges to sustaining enhanced aviation security.
Since September 11, 2001, TSA has made considerable progress in meeting congressional mandates designed to increase aviation security. By the end of 2002, the agency had hired and deployed about 65,000 passenger and baggage screeners, federal air marshals, and others, and it was using explosives detection equipment to screen about 90 percent of all checked baggage. TSA is also initiating or developing efforts that focus on the use of technology and information to advance security. One effort under development, the next-generation Computer-Assisted Passenger Prescreening System (CAPPS II), would use national security and commercial databases to identify passengers who could pose risks for additional screening. Concerns about privacy rights will need to be addressed as this system moves toward implementation. Although TSA has focused on ensuring that bombs and other threat items are not carried onto planes by passengers or in their luggage, vulnerabilities remain in air cargo, general aviation, and airport perimeter security. Each year, an estimated 12.5 million tons of cargo are transported on all-cargo and passenger planes, yet very little air cargo is screened for explosives. We have previously recommended, and the industry has suggested, that TSA use a risk-management approach to set priorities as it works with the industry to determine the next steps in strengthening aviation security. TSA faces longer-term management and organizational challenges to sustaining enhanced aviation security that include (1) developing and implementing a comprehensive risk management approach, (2) paying for increased aviation security needs and controlling costs, (3) establishing effective coordination among the many entities involved in aviation security, (4) strategically managing its workforce, and (5) building a results-oriented culture within the new Department of Homeland Security. TSA has begun to respond to recommendations we have made addressing many of these challenges, and we have other studies in progress.
Dec 12, 2013
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Website Detail Page
technical implementer:
the National Engineers Week
published by the National Engineers Week
This website is designed to introduce kids to engineering. It includes a section with brief career profiles of various engineering career paths, but the real fun is in the videos. Featuring kids engaged in activities that illuminate key concepts in engineering, these videos showcase the work of engineering in a dynamic and exciting format. For example, one video covers the biomechanics of skateboarding -- taking real kids on a field trip to the Etnies Shoes headquarters where they learn how engineers (who are also skateboarders) use science to design shoes that help absorb impact and minimize injury. Another video takes a group of kids to Disney World to experience how Disney engineers transform potential energy into thrilling roller coaster rides. All of the videos feature a related hands-on activity to let students apply the science concepts involved.
ComPADRE is beta testing Citation Styles!
Record Link
National Engineers Week. Discover Engineering. Alexandria: National Engineers Week, February 1, 2013.
AIP Format
(National Engineers Week, Alexandria, 2000), WWW Document, (http://www.discoverengineering.org/).
Discover Engineering (National Engineers Week, Alexandria, 2000), <http://www.discoverengineering.org/>.
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Discover Engineering. (2013, February 1). Retrieved December 11, 2013, from National Engineers Week: http://www.discoverengineering.org/
Chicago Format
National Engineers Week. Discover Engineering. Alexandria: National Engineers Week, February 1, 2013. http://www.discoverengineering.org/ (accessed 11 December 2013).
MLA Format
Discover Engineering. Alexandria: National Engineers Week, 2000. 1 Feb. 2013. National Engineers Week. 11 Dec. 2013 <http://www.discoverengineering.org/>.
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Title = {Discover Engineering},
Publisher = {National Engineers Week},
Volume = {2013},
Number = {11 December 2013},
Month = {February 1, 2013},
Year = {2000}
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%T Discover Engineering
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The AIP Style presented is based on information from the AIP Style Manual. The APA Style presented is based on information from APA Style.org: Electronic References. The Chicago Style presented is based on information from Examples of Chicago-Style Documentation. The MLA Style presented is based on information from the MLA FAQ. This resource is stored in a shared folder. You must login to access shared folders. Discover Engineering:
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You Tube: Discover Engineering - The Sum of all Thrills
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Mathema Hedge Fund Strategy Insight Report for January 2012
By Chris ClairResearch firm Mathema finds that intracorrelation was lower in 2011 than it was in 2010 for managers in convertible arbitrage, global macro and long/short equity strategies. Intracorrelation is the tendency for managers and strategies to be correlated with one another. Lower intracorrelation usually means higher levels of diversification for investors in those strategies, and higher risk-adjusted rates of return.
In its report Mathema also goes into detail about market conditions, gauges investment risk for various strategies and sets the risk assessment and outlook for hedge fund strategies.
Read the entire report by clicking on the link below (PDF).


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SMF Support > SMF 2.0.x Support
free classifieds for forum
Hi guys,
Is there any free classifieds mods that i can add to my site.
im actually not sure, but i'll look and let you know, I would be interested as well. If not you can simply add a "For Sale" to your board and add child board based on most common items sold, or whatever your forum is themed on. Kinda what I do. I'll look anyway
UPDATE* Well I could not find what you were looking for, so maybe a request for someone to make such a Mod, or go the route i told you in the mean time.. Good Luck
There is not a free classifieds mod for SMF if that's what you mean by "my site".
Here is one you can pay for.
I use a few of SMF Hacks mods, free and paid ones.
His mods work great and support is top notch.
yep thats what i mean.
cant believe there isnt a free classified mod.
Arantor Beeblebrox the First:
Why exactly do you think that is?
Take someone like me, do you think I'd spend hundreds of hours writing something that's going to make you money and not expect some myself out of it?
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rag & bone/JEAN
Pampola Pullover
Rag & Bone was born in 2001 through the shared frustrations of not being able to find the type of clothing everyone wanted to wear. With all manufacturing done in America this brings all the history and skill to each individual piece more to life. Unique and set apart these pieces were made to be.
- 100% linen
- Dry clean only
- Styled with rag & bone/JEAN The Skinny in Destroyed.
- Modeled in size S. See fit guide for model's dimensions.
- Revolve Style No. RAGA-WS57
- Manufacturer Style No. W224602


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"The Life And Times Of Prophecy"
Aubrey O'Day And Melissa Molinaro Reunite Over A Toasty Power Lunch
posted by Garry "Prophecy" Sun on March 8, 2012
Former Making The Band 3 Castmates, Aubrey O'Day and Melissa Molinaro decided to have lunch at Toast on 3rd Street in West Hollywood, probably reminiscing on the Good ole MTV Days… Life was much simpler then.
Both decided to have some pretty health conscious and nourishing meals, while showing off their pups… Aubrey brought Ginger (pink cotton candy ball) and MaryAnne (blue cotton candy ball) and Melissa brought her pup named after one of the Five Boroughs… Bronx.
Crazy part is when tiny MaryAnne damn near munched off Bronx's entire head… Whoah there MaryAnne. it's not that kind of lunch.
Garry "Prophecy" Sun for SunOfHollywood.com
Photos: SunOfHollywood.com
Photos: SunOfHollywood.com


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Questions & Answers : Search Results
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how do i get software for magic trackpad?
- Asked by Herman A. B from Lexington
- Jul 29, 2010
- Flag as inappropriate
where do I get Latest Magic Trackpad software update
- Asked by Eva Marie F from Olympia
- Aug 4, 2010
- Flag as inappropriate
How can I tell the Magic Trackpad power is off?
When I push the power button to toggle power, the device continues to work regardless of power state. How do I turn it off and know it is off?
- Asked by John C from Choctaw
- Nov 23, 2012
- Flag as inappropriate
Will the magic trackpad work with Mac mini?
I am getting a new Mac mini and I expect to get all the accessories as well.
- Asked by Aaron L from Camarillo
- Dec 20, 2011
- Flag as inappropriate
Does the magic trackpad work with dj spin, is it responsive enough to que up records & beat sync?
Dj spin software & magic trackpad
- Asked by Jason P
- Aug 19, 2012
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No answers yet
Is the magic trackpad easy to bring around?
My trackpad on my mac is acting on its own and the Apple store said that I have to pay 1300 dollars to get it fixed because AppleCare doesn't cover it. Should I buy this so I can replace my trackpad?
- Asked by Olivia L from Cresskill
- Apr 29, 2013
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Does the Magic Trackpad work with multiple monitors?
With a mouse, I have to drag the mouse around to get to the second monitor. I would imagine that the whole trackpad would map to the size of both screens, but would this cause it to be a little harder to control? Or less precise?
- Asked by Vincent A from Johnston
- Jul 29, 2010
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Would my iMacs RAM effect tracking speed/lag when using the magic trackpad?
I am currently running a stock 21.5 " i5 iMac 4GB RAM and notice that I only max out about 2.50 Gb or so memory when multitasking and using the system normally.
I recently purchased a magic trackpad which I have had replaced by Apple as my old one was faulty and have found that in one spot of the trackpad I get slight cursor delay.
This was the exact same problem (there were other problems also with my old one) that happened with my previous trackpad so I'm starting to think this now must be a software fault.
Unless there are any issues with mountain lion (I'm running the latest version) that I'm not aware of the only other explanation I can think of is the RAM.
Would RAM have an effect on cursor delay on a trackpad? I find it hard to believe I've had two trackpads with the same issue and it has been in the exact same place (In the bottom right hand corner of the pad)
Would upgrading my RAM to 8GB have any effect?
Any thoughts on the issue?
(I was also thinking it may be related to the notification centre gesture in some way as you have to swipe with two fingers from the right to active this)- Asked by Jonathan H
- Oct 15, 2012
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No answers yet
Will the magic trackpad work with my macbook air.
- Asked by Karl G
- Oct 10, 2012
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could a magic trackpad work with windows 7
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- Dec 21, 2012
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the magic trackpad can be use to macbookpro and ipad 2?
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- Sep 19, 2012
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Does it work with VoiceOver -- does the software update add a TrackPad Commander tab in VoiceOver Utility when a Magic Trackpad is detected?
- Asked by Tim S from Lakewood
- Jul 27, 2010
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Can I use both the magic mouse and the magic trackpad?
Can both the Magic Mouse and the Magic Trackpad be linked with the computer at the same time?
- Asked by Carmen Tam M from Saratoga
- Sep 16, 2011
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trackpad and Mac mini
I have purchased a Trackpad and it will not work with my mac mini.
the mini says software is up to date but the track pad requires OSX 10.6 my mini is supposedly up to date with 10.5.
what can I do to get my trackpad to work- Asked by Paul M from West Vancouver
- Nov 18, 2010
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Can you scroll up and down on the Magic Trackpad as in the powerbook trackpad?
- Asked by Adriana S from Naucalpan
- Nov 5, 2010
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Is it possible to enable a CTRL-click option with the magic trackpad?
I mean to get the context menu without having to actually hold down the CTRL key (right-click in WNDWS)
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- Jul 28, 2010
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Can I use the magic trackpad and magic mouse at the same time?
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magic trackpad and color
will it be possible to map certain controls so the magic trackpad can be used with color as a controller?
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- Jul 27, 2010
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Locking a Magic Trackpad
Does anyone know of a way to secure a Magic Trackpad? I am wanting to use one for work, but am not sure how to secure it to my desk to make sure someone doesn't steal it. Is there a way to do this?
- Asked by Luke S from Aloha
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text: Give me more cable, charge me less, pay me to use the service by Gary Gardiner • December 7, 2012 Just finished a change in service phone call with Time Warner. It was very strange. Was looking to see if there was a way to cut the bill as I've had several friends who pay less than I do. Been… Read more →


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A Milwaukee doctor uses the same technology as astronomers to intervene early on in eye disease.
Credit Medical College of WisconsinDr. Joseph Carroll reviewing the results of adaptive optics imaging with technician Brian Higgins and neuroscience student Melissa Wilk.Edit | Remove
Joan Chittister has long been one of my favorite writers and always leads me to new insights and heights of understanding. Her most recent effort centered, of all things, on a bathtub. And what she did was hammer home an important fact of life in this speedway, helter-skelter 21st century. This is the way she put it:
UW System is dealing with an unprecedented budget situation; going from a proposed increase in state funding to a proposed cut in funding.
Members of the UW Board of Regents expressed regret Thursday, that they did not adequately detail the UW System's finances to legislators.
Lake Effect essayist Young Kim say coercing food stamp recipients to buy only "healthy food" is the wrong way to go about it.


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Hiltz Waste Disposal, Inc is a family owned and operated Waste and Recycling Removal business with over 38 years of proven industry experience. Located on Cape Ann in historic Gloucester Massachusetts, we provide outstanding service to the surrounding communities in Eastern Massachusetts as well as southern New Hampshire (see list of towns we service).
We specialize in Residential, Commercial and Industrial waste removal and Recycling services. Hiltz Disposal prides itself on providing the highest level of service available in the industry at competitive prices. We are large enough to meet the needs of contractors, commercial customers and home owners, yet small enough to provide personalized service. You will find our office staff and our drivers to be courteous and attentive to your needs. |


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Attend an M.S. in Management Class
Accounting & Financial Aspects of Business
This course is an introduction to financial management concepts and business practices. It includes the topics of accounting, finance and related analytical and performance management techniques that have particular relevance to managers. In this course, you should become fluent in the issues, data, and concepts of financial decision-making at the organizational level. By the conclusion of this course, you should understand what financial managers do in an organization and how to deal more effectively with them on issues of business and program strategy. This will require you to be able to: . Use basic business mathematics to inform decision making: . Understand how organizations are financed; . Read and understand a set of financial statements . Calculate and interpret financial ratios; and perform a financial analysis; . Conduct basic cost analyses and understand their role in managerial decision-making; . Prepare and discuss a budget, the sources and importance of variance, and the concept of flexible budgeting as a control device; . Understand investment project decision making and be able to compute measures of return (NPV, breakeven); . Use Excel to create, interpret, and present results from financial models.
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