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Showing 1-14 of 14 items found in Events
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Dec 24
Victorian Christmas on the Woodstock Square
Not to be missed is Woodstock's Victorian Christmas celebration that begins each Thanksgiving weekend. The Square glows with thousands of miniature lights illuminating the buildings and trees for the annual Festival of Lights. Carolers stroll the streets and visitors can take horse-drawn carriage rides around the Square. Friday November 29, 2013, 7:00pm. Lighting of the Square Sunday December 1, 2013, 2:00pm. Holiday Parade. Every Friday and Saturday November 29, 2013-December 21, 2013 Carriage Rides around the Square.
CITY: Woodstock
10 - 11
Tough Mudder
Tough Mudder events are hardcore obstacle courses designed to test your all around strength, stamina, mental grit and camaraderie. With the most innovative courses, over one million inspiring participants worldwide to date, and more than $5 million raised for the Wounded Warrior Project, Tough Mudder is the premier adventure challenge series in the world. But Tough Mudder is more than an event; it's a way of thinking. By running a Tough Mudder challenge, you'll unlock a true sense of accomplishment, have a great time and discover camaraderie with your fellow participants that's experienced all too rarely these days.
CITY: Richmond
Jan 4
Winter Wonderland Holiday Light Show
A Lake County holiday tradition. Visit Northern Illinois' largest drive-through Holiday Light Festival, held at the Cuneo Mansion, and view thousands of twinkling lights, animated displays and holiday decorations. While visiting the light show, the Cuneo Mansion & Gardens invites you to walk through the museum for a magical view of Christmas' past. Please visit the website for more information.
CITY: Vernon Hills
21 - 22
The Nutcracker
Even the youngest sugarplum will eagerly follow the heroine, Clara, as her lively imagination leads her on a wonderful journey filled with colorful characters: the fearsome Mouse King, dazzling dancers from many lands, the beautiful Sugarplum Fairy and, of course, the Nutcracker Prince! This fresh, lively and thoroughly entertaining production is sure to become a favorite for the entire family. Don't miss the Ruth Page Civic Ballet perform this holiday tradition.
CITY: Grayslake
Feb 2
Groundhog Days
In 1992, something astonishing happened in the historic city of Woodstock, Illinois. People came to town and roped off the picturesque city square, moved all sorts of equipment into the park and started playing the Pennsylvania Polka, over and over and over again. They were filming a movie that has become a favorite of young and old for more than 20 years, and the city gathers each year to remember the fun and celebrate the special community that Woodstock has always been. There are events for everyone during this celebration: Groundhog trivia, free viewing of "Groundhog Day" at the movie theater, walking tours of the film sites, a Chili cook-off, a dinner and dance, bowling, bags tourney, and a pancake breakfast. The main event for Groundhog Day is the annual prognostication. Gather on the Woodstock Square to see Woodstock Willie emerge from his tree trunk home. If he sees his shadow, it means there will be 6 more weeks of winter and if he doesn't see his shadow, it means we will have an early Spring.
CITY: Woodstock
7 - 21
Gingerbread Walk & Scavenger Hunt
Bring the family and friends to Downtown Antioch to hunt for Gingerbread! Find delightful Gingerbread Sculptures of Houses and other unique creations. Fill out a contest entry form and track down the different Gingerbread Clues throughout Downtown. Turn in the completed entry form for a chance to win exciting prizes and vote for the best one. Enjoy strolling musicians and carolers on Saturdays while finishing all the holiday shopping.
CITY: Antioch
8 - 16
Happy Holiday Railway at the Illinois Railway Museum
Embark on a magical train ride! Visit with Santa Claus at the Toy Workshop and receive a gift to take home. Children on Santa's "Good" list will receive a gift and treat. Enjoy music and live entertainment.
CITY: Union
25 - 26
Annual Norge Ski Jump Tournament
Fun for the whole family. Great food and beverages. Ski Jumpers from around the world will be competing. Tournament starts at noon both days. Shuttle Bus (Sunday Only)-Picks up at Dominick's (Route 22 & 14) and the Fox River Grove Train Station. U.S. Cup & International 5 Hills Ski Jumping Winter Tournament. Junior National Qualifier--Junior Ski Jumpers compete on the big hill (Saturday) for a spot representing the Central Division for the Championship in Anchorage, Alaska in March. USA Ski Team Jumpers will compete on Saturday for U.S. Cup Points, Cash and National Rankings in their 6th stop on the National Tour which wraps up in March in Park City, Utah. International Ski Jumping Teams will compete head to head with U.S. Jumpers, both days for number 3 of 5 Competitions in the Midwest's Five-Hills Tournament. Pre-Sale Buttons available 2 weeks before the Tournament: $10 at local merchants $11 Will-Call online at www.norgeskiclub.com $15 at the gate on Tournament days
CITY: Fox River Grove
Volo Bog's WinterFest
Looking for a great combination of indoor and outdoor fun in mid January? WinterFest is a long-standing event at Volo Bog featuring live music and storytelling, photo contest awards, and winter-theme and other crafts indoors, while outdoors winter bog hikes, and snow permitting - snow sculpting contests and cross-country skiing, may be enjoyed throughout the afternoon. There will also be cookies, hot cocoa & coffee for sale by the Friends of Volo Bog. Visit the website for a complete agenda. Donations accepted.
CITY: Ingleside
Frozen Gnome 50K/10K
There's no place like Gnome! The Frozen Gnome's beautiful single-track course will take runners through the winter wonderland of Veteran Acres and Sterne's Woods.
CITY: Crystal Lake
23 - 27
86th Annual Lake County Fair
Come out and enjoy 5 days of fun at the 86th Annual Lake County Fair. Events at the fair include live entertainment, food vendors, carnival rides and games, live animals, motor crossing, banana derby, demolition derby, flower show, expo hall and so much more. Please visit the website for updated information.
CITY: Grayslake
21 - 29
Holiday Hoedown
Santa is inviting kids of all ages to come join him on the ranch for the first ever Holiday Hoedown! This indoor, winter festival will feature a Magical Midway of rides, games, and food, Santa's Farm with Jingle Bell Junction train rides and hayrides, Frosty's Fairway mini golf, Gingerbread Square entertainment & special events, holiday vendors, Blitzen's Brewery, and more! Closed December 24 & 25. Admission is free, but there is a parking fee.
CITY: Grayslake
Paddock Hills Equestrian Center
Imagine a golden ball of Midwestern sun breaking on the horizon. As the night dew still clings to the vines and the grass in the pastures, a farm comes to life with the sights and sounds of morning. Hot coffee steeps in the pot. Hard-working farm-hands begin the daily chores. Horses whinny as the cool rush of morning air fills their lungs. The gently rolling hills are aglow with another new day. This is the beauty of horses and the magic of a vineyard. Paddock Hills Equestrian Center is located with Prairie Orchard Farm vineyard in the majestic countryside of Union, IL, and is minutes from the I-90 expressway, but miles away from the hustle and bustle of the city and suburbs. Whether, attending one of our many horse shows, riding lessons, clinics, or programs, we are sure that your time with us will be well spent.
CITY: Union
Des Plaines River Trail Marathon Races
Welcome to year five of the Des Plaines River Trail Half-Marathon, Marathon and 50 Mile Ultra Marathon along the beautiful and fast Des Plaines River Trail. This is a truly special running course. The DPR Trail is a wide, crushed gravel track, free of roots and rocks, and very flat. All of the major road crossings are managed by way of bridges or viaducts This is a great track through alternating lush forests and open wetlands. With cool temperatures expected, and given the flat terrain and ideal running surface, you'll find these to be extremely fast courses. Registration is open until it reaches full capacity or October 10th. Register early and save.
CITY: Vernon Hills
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Dog Wags Pillow is perfect for the dog lover in your life! Adorable decorative pillow features a tapestry-look cover stitched with hearts, paw prints and an oh-so-true message about man's best friend. Poly/cotton blend with a plush, black "fur" backing and poly fill. 12-1/2" L x 8-1/2" W. Made in USA.
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Spencerport man suffers serious injuries in snowmobile accident in Kendall
Posted at: 01/23/2013 6:11 PM
A Spencerport man suffered serious injuries after he was ejected from his snowmobile.
The incident happened just before 2:30 p.m. in an area north of Roosevelt Highway(State Route 18) and east of Kendall Road (State Route 237).
The Orleans County Sheriff's Office says John P. Battista, 35, of Spencerport and Frederick A. Kirkpatrick, 46, of Rochester, were operating separate sleds and headed toward the snowmobile trail when Battista's machine ran into a drainage ditch. Sheriff's Deputies say Battista, who was wearing a helmet, was ejected and thrown head first into Kirkpatrick's snowmobile.
Battista was taken to Strong Memorial Hospital with a serious head injury. Kirkpatrick was not injured.
Have a story you want our news team to investigate? Call us at 585-232-1010, click here to send us an e-mail or leave us a Facebook post or tweet.
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"A massive solar flare the strongest one so far this year erupted today (Jan. 27) from the same active region..." More here.
"An armed society is a polite society. Manners are good when one may have to back up his acts with his life." - Robert A Heinlein
Good. Maybe propagation will pick up...
OK, after all the excitement, how does this help radio amateurs ? G0GQK
Originally Posted by G0GQK OK, after all the excitement, how does this help radio amateurs ? G0GQK For most solar flares, the main effect felt on Earth is an increase in the level of solar radiation. This radiation covers the whole electromagnetic spectrum and elements such as the ultra-violet, X-rays and the like will affect the levels of ionisation in the ionosphere and hence it has an effect on radio communications via the ionosphere. Often an enhancement in ionospheric HF propagation is noticed as the higher layers of the ionosphere have increased levels of iononisation. However if the levels of ionisation in the lower elvels start to rise then this can result in higher levels of attenuation of the radio communications signals and poor conditions may be experienced. Additionally an increase in the level of background noise at VHF can also be detected easily. Flares generally only last for about an hour, after which the surface of the Sun returns to normal although some Post Flare Loops remain for some time afterwards. The flares affect radio propagation and radio communications on Earth and the effects may be noticed for some time afterwards.
G0GQK, solar flares improve HF activity like crazy 10 meters was widely spread open yesterday because of the storm the radio flux index was at a high of 283 percent the propergation picked up very very nicely yesterday the highest it has ever been that was good to transmit on hf yesterday was very interesting to working 10 i'm sure other fellow hams had fun transmitting on there hf radio yesterday i know i did i worked 10 meters just fine but today cannot work 10 at all
Please listen for me between 28.400-28.490 73s Greg K7GAV MY ECHOLINK NODE IS 456934 Ham Radio Deluxe V5 511A KENWOOD TS2000 ONLINE ASTRON 35AMP ALSO ONLINE CAT INTERFACE : USB63B : USB Serial Port Converter
10 seems dead in Minnesota and 15 is weak, but then I've got an attic dipole with a high take-off angle for the signal, so probably miss a lot anyway. (Heck, for me 10 was dead for half the last decade, though did work a ZM and a VK in October.) Guess they will come back soon enough. As an aside, K1MAN is strong on 14.275. Thought he just got a big fine for broadcasting.
Yeh but conditions are stinky now..great 2hours ago. Must be 'post coronal depression' ;-) 73 Chip W1YW
Originally Posted by W1YW Yeh but conditions are stinky now..great 2hours ago. Must be 'post coronal depression' ;-) 73 Chip W1YW hearing you guys here in oz n4lem on 14.200 talking all over the states. Ray is 5/9 here.
Originally Posted by W1YW Must be 'post coronal depression' Is that what we call hangovers now?
Are you guys saying the SFI got up to 280?
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text: Do you have customer support? Our friendly, knowledgeable support staff is here when you need us. Online support is available Mondays through Fridays from 9am to 6pm, Pacific Standard Time. Our voice mail system is also available 24 hours a day, 7 days a week. Do you offer free shipping? Order $100.00 or more of merchandise on BoardersMall, and well ship it to you via FedEx Ground absolutely FREE, within the continental U.S. (except Alaska & Hawaii) Want your stuff sooner? You can also upgrade your shipping preferences from a choice of delivery options and carriers during the checkout process (additional charges apply). SORRY, FREE SHIPPING IS NOT AVAILABLE ON CLOSEOUT ITEMS. Do you deliver outside the continental United States? Yes we do. BoardersMall is not responsible for additional charges (taxes & duties, etc.) on orders placed outside the continental U.S. All orders are subject to current U.P.S. or FedEx shipping rates. For more information, please call us at 866-667-9253 or send an e-mail to: email@example.com. Please be advised that some of the manufacturors prohibit sales outsite of the USA. What do you do about oversized shipping? Any products weighing over 35lbs. or exceeding standard shipping requirements will be sent to you via private freight, and additional shipping charges not shown here will apply to your account. Do I have to pay sales tax? Buy your watersports equipment at BoardersMall, and you pay NO SALES TAX (except in California). Do you have a low price guarantee? Yes, please see our Price Guarantee page Where do you ship? We can ship your order to just about everywhere in the world! United States, Canada, Mexico, South America, Europe, Australia, etc... If you live outside the United States, additional charges may be applied to your order, including import/brokerage/handling fees or taxes. BoardersMall does not collect or control these fees, and we have no way of knowing if/how much you will be charged. Please verify your country's policies before placing your order. Please be advised that some of the manufacturors prohibit sales outsite of the USA. How much will it cost to ship my order? When will I get my order? These charges vary, depending on your selected shipping method, the country you are shipping to, how many items you have in your cart, and the total weight of your order. Place your order before 10:30am PST, and we will process it the same business day. (All orders placed later than 10:30am process the following business day). How can I contact you? You can call us toll free at 866-667-9253 during regular business hours, or you can use our Contact Us page. Who runs BoardersMall? You can find that info on our About Us page. Can I link to BoardersMall.com? Of course! © 2006 BoardersMall - ALL RIGHTS RESERVED


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Tour Munich in Classic BMW Cabriolets
Planning a trip to Munich any time soon? There are plenty of reasons to stop by the BMW Museum, but now we've got one more for you. Over the course of the Spring, Summer and into the Fall, BMW Classics is offering chauffeured tours of the city in a range of classic convertibles.
The tours take place in such vintage Bimmers as the 30s-era 326 and 335 Cabriolet, 50s-era 502 "Baroque Angel" Cabriolet and the one-of-a-kind 3200 CS Cabriolet. Tours start and end at the BMW Museum, visit various company facilities and stop at historic sites around the city. The price is 90 euros per person. Details at www.bmw-museum.com.


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Golden Elegance MirrorBy: Marie LeFevre for Krylon Ornate gold stenciling and rich Burgundy color transform a basic mirror and frames into a beautiful home decor accent from Krylon. Supplies:
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Since 2003, Veincentre Ltd has performed over 3,000 successful EVLA (EVLT®) treatments for varicose veins. So confident are they that they can successfully manage all types of varicose vein without surgery that they offer a same day consultation and varicose vein treatment service. This means you can be assessed, treated and back on the train home in less than two hours!
Veincentre manage all patients without surgery. This has the following distinct advantages.
No general anaesthesia
No time off work
No cuts
No scars
Little recurrence
High patient satisfaction
Few complications
Veincentre Ltd. was the UK's first private company established specifically to provide Endovenous Laser Ablation (EVLA) of varicose veins. The consultant vascular specialists have extensive experience in all aspects of non-surgical varicose vein diagnosis and treatment. The Medical Director, Dr David West, is a leading authority in this field and trains doctors from all over Europe and beyond. He is much in demand as a lecturer and runs training workshops at premier UK and European vascular conferences. He has written several chapters on varicose vein management in major medical textbooks.
Some patients can be managed successfully using EVLA alone. Many require foam sclerotherapy in addition and there are some who need more specialised procedures such as embolisation and RF ablation of perforators. It is only by offering, having experience of and having the facilities to undertake, the whole range non-surgical vein treatments that every patient can avoid surgery and general anaesthetic. Many clinics don't have a full range of facilities and expertise and will offer EVLA or VNUS to some patients but still resort to surgery in up to a third of patients.
All the company's systems and processes have undergone rigorous assessment by the Care Quality Commission with whom Veincentre is registered.
Their London clinic is conveniently situated in Knaresborough Place, South Kensington close to Earls Court tube station. The Manchester clinic is located a minute's walk from the London to Manchester rail line; the Staffordshire clinic 2 minutes from junction 15 of the M6 and the Bristol clinic in Clifton and many patients, from all over the UK, find it more convenient and far cheaper to travel to us than seek treatment locally.
Veincentre is proud to be not only one of the busiest most experienced and most respected vein clinics in the UK but also the cheapest. They keep costs down through high throughput, efficient working practices and high volume discounts on consumable purchasing. Quality does not have to cost the earth.
Phone Diane or Deborah on 01782 753960 for an introduction to the patient centred, friendly service. They will be pleased to answer any queries or arrange a consultation and/or treatment date.
A full description of the services including videos of procedures and a comprehensive price list can be found at www.veincentre.com
Veincentre Manchester
St John Chambers
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North Staffs Nuffield Hospital
Clayton Road
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Veincentre (London)
10 Knaresborough Place
South Kensington
Veincentre Bristol
1 Whiteladies Rd
Tel: 01782 753960 or 07000 4 VEINS
Email: email@example.com
Website: www.veincentre.com
N.B. Veincentre Ltd. is not related in any way to northofenglandveincentre, the London Veincentre or any other clinics using the term veincentre in their title.
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New Requirement to Receive Unemployment Insurance Benefits Beginning October 2013
Due to a recent change in Indiana law, Hoosiers receiving unemployment insurance benefits must visit their local WorkOne for a review of their work search records and an orientation to WorkOne services after their 4th week of benefits. You are also required by law to keep records of your 3 weekly work searches and be able to show a record of work searches when requested. If a record of work searches cannot be readily verified at the in-person visit, weekly benefits could be withheld. This in-person visit is part of a new law passed aimed at getting unemployed Hoosiers back to work as quickly as possible. Hoosiers who are required to visit a WorkOne will begin receiving notices in October. Anyone who fails to comply risks losing their unemployment insurance benefits. Click here for more information.
New GED Test in 2014
Did you know the current version of the GED test will expire at the end of this year and Indiana will have a new high school equivalency test beginning in 2014? Your scores will expire too if you don't finish and pass the test before the end of the year. If you have questions about how this will affect you or would like more information about Adult Education classes and other FREE programs, visit www.in.gov/dwd/adulted.htm, or call 1-800-891-6499.
Federally Extended Benefit (EEUC) Reductions Ending Dec. 9, 2013
Due to ending of federal spending cuts, also known as sequestration, beginning Monday, December 9, 2013, weekly payments of Federally Extended Unemployment Insurance benefits, also known as EEUC, or weeks 27-63 of benefits, will be increased by 10.7%. Regular State Unemployment Insurance benefits or weeks 1-26 will not be affected. Click here for more information. Please be sure to check your Uplink homepage and DWD's website regularly for any updates on this issue.
New Requirements to Receive Benefits
Unemployed Hoosiers who are finishing their first 26 weeks of regular state unemployment insurance and moving to federally funded extended benefits are now required to go to WorkOne for an in-person review of their work search records. The new in-person review is part of the federal law Congress passed in February reauthorizing the federally funded extended benefits through the end of the year. Reviews will also be required for those transitioning from the first round of federal benefits to the second if they have not previously participated. Hoosiers who are required to visit a WorkOne will begin receiving notices in April. Anyone who fails to comply risks losing their unemployment insurance benefits. Click here for additional information.


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Medical Practice Costs Creep Higher
A year-to-year comparison of cost increases at both physician- and hospital-owned medical practices shows senior executives and administrators are increasingly being called on to build efficiencies.
MGMA-ACMPE (formerly the Management Group Medical Association) released on Wednesday its annual report on cost data gathered from member and non-member practices. Published since the mid-1950's, the Cost Survey for Multispecialty Practices: 2012 Report Based on 2011 Details, is a 300+ page benchmark report used by practices to measure how their spending and cost increases compare to their peers.
Overall, says Todd Evenson, director of data solutions for MGMA-ACMPE, there's been a "64% increase in total operating costs for multi-specialty practices" since 2001. In comparison, 2011 shows a modest 1.27% increase from 2010 for physician-owned practices.
In real dollars, that amounts to $528,182 in operating costs per full-time employee physician. Hospital/Integrated Delivery System (IDS)-owned organizations saw a 6.45% increase in operating costs, or $387,586. Evenson cautions against comparing the operating costs of the two models because they operate so differently.
Instead, Evenson says it's more significant to look at the single-digit increases in growth of each, saying the 2011 figures show "medical groups are laboring to bend the cost-growth curve."
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- Scary Financial Challenges for 2014
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- Hospital M&A Volume Up, Value Down in 3Q
- Small Doesn't Mean Doomed


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Jaakonsaari Liisa (Member)
Liisa Jaakonssari is a member of the Group of the Progressive Alliance of Socialists and Democrats in the European Parliament.
She is Vice-Chairwoman of the Special Committee on the Financial, Economic and Social Crisis. She is a member of the Employment and Social Affairs Committee and a substitute on the Committee on Foreign Affairs.
Ms Jaakonssari joined the European Alzheimer's Alliance and signed the Paris Declaration in 2009.
Last Updated: mercredi 05 janvier 2011


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With a trio of rate increases awaiting approval this week by the Hannibal Board of Public Works board, an outspoken figure from Hannibal's political past raised questions about the utility at Tuesday's Hannibal City Council meeting.
Former Mayor John Lyng spoke briefly to the council at the outset of Tuesday's meeting, asking the council to take steps to "gain some accountability for the Hannibal Board of Public Works to the citizens who own those public utilities."
Lyng, who served as mayor in the early 1980s, said the customary public hearing on rate increases that will be held Thursday evening, just before the BPW board votes on those increases, has become a formality. He called for "some second level of approval of rate increases," with electoral accountability; the BPW board is appointed.
"And yeah, I'm looking at you fellows," Lyng told the council.
The rate increases set for a vote Thursday include a 5 percent residential-only hike in electric rates, 8 percent for sewer and 10 percent for water. In total, the three are expected to add $10 to the average monthly utility bill.
Lyng criticized the minimum customer charge in all three divisions, which also is expected to rise. However, he said the hike in electric usage rates, in particular, comes at a time when wholesale power costs are dropping for the city. He likened the residential-only increase to Ford hypothetically raising prices on cars only for its own stockholders.
The former mayor also called for the council to write into the city charter owner approval — that is, voter approval — of financial borrowing and major investments. The latter was a jab at the massive Prairie State Energy Campus in southern Illinois, of which the BPW is a part owner through the Missouri Public Utility Alliance; the plant has yet to begin generating power and revenue, but the BPW already is paying for its construction to the tune of $300,000 a month. (Note that all MPUA member cities have some financial skin in the plant as members of that organization.)
Although the BPW is considered part of city government, its operations traditionally have been fairly detached from City Hall. Lyng said the council should be doing more to hold the BPW accountable.
BPW General Manager Bob Stevenson and Board President Randy Park were in attendance at Tuesday's meeting, but did not speak or offer a response to Lyng's comments.
The council took no action with regard to the former mayor's remarks, but Fourth Ward Councilman Barry Louderman acknowledged that the council and utility have had a "tenuous" relationship through the years.
This isn't the first time a Lyng has called for BPW reforms in recent years. His son, former Sixth Ward Councilman Jeff Lyng, was similarly outspoken about the utility.


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The Munroe volleyball team defeated a very good FAMU-DRS volleyball team twice during the regular season. Once they won in five games, going overtime in the fifth game of the match before winning 17-15. The second time they met, the Lady Cats played some of their best volleyball of the year and dominated the Rattlers in three straight games.
Sports Correspondent
After an emotional two weeks and a decisive win against conference opponent Oak Hall, the Bobcats of Robert F. Munroe ran into a buzz saw at Rocky Bayou, succumbing to the balanced rushing and passing attack of the home standing Knights 56-13.
"We were a little flat," said Interim Coach Joey Edwards, "but Rocky Bayou was an experienced team and well-coached. They kept the pressure on and took advantage of their scoring opportunities."
This past week marked the end of regular season volleyball contests for FHSAA member schools. This week all four teams will be participating in district play, hoping to extend their seasons with post-season play. Results from last week, however include:
MUNROE VS. NORTH BAY HAVEN: The Lady Cats put together a very good effort on Senior Night, defeating North Bay Haven of Panama City in four games. Three of the four games were very close with the Lady Cats winning game 1 25-23, game 3 26-24 and game 4 25-23.
Times Correspondent
Ronald Thompkins, CPA and Managing Partner of the Florida offices of the Watson and Rice auditing firm, addressed the Quincy City Commission during the regular meeting Oct. 8 on the need to bring in an outside resource to assist with the internal audit originally scheduled to be completed in June.
Fall's iconic squash took the spotlight in Havana as people piled into the downtown area for the 14th annual Pumpkin Festival.
"This was my first time attending the festival, and I can definitely say I will be back next year," said Tallahassee resident Brandie Scott. "It's an event that your whole family could enjoy."
At the Oct. 10 meeting of the Midway City Council, Mayor Pro Tem David Knight (District 6, at-large) was officially sworn in as the mayor of Midway, replacing embattled Jerrod Holton, who recently resigned.
The Robert F. Munroe Bobcats returned to the winner's circle with a 52-13 dismantling of the visiting Eagles of Oak Hall. The Bobcats rushed for 527 yards and the defense stymied the Eagles' ground attack while forcing three turnovers. The Bobcats also had three players rush for over 100 yards.
Final practices and preparations are in place this week in anticipation of district volleyball tournaments next week. Munroe and Tallavana are both in the same District2-2A. Munroe is the top seed in the district and Tallavana the bottom seed. The Lion will face FAMU on Tuesday at FAMU in the first round, and the winner will play Munroe for the championship at FAMU on Thursday.
Stylish assembly at Mt. Pilgrim
The public is cordially invited to Mt. Pilgrim P.B. Church, Annual 100 Women in White, 100 Men in Black program. It will start at 3 p.m. Sunday, Oct. 20. Elder Matthew Bryant will be the speaker. Elder Aaron Bush, Pastor.
Word Alive Ministries
celebrates Apostle Alexis


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979 search results for Billboard 200
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Garth Brooks nabs No. 1 album in the country from Britney Spears debut
Boxed set trumps One Direction, Duck Dynasty, Kelly Clarkson
Will Britney Spears or Garth Brooks have the No. 1 album next week?
How is 'Britney Jean' looking as we go into the weekend?
2014 Grammy Award nominations: Surprises and snubs
Though he snagged seven nominations, tying him with the most for all artists,...
One Direction makes Billboard history with No. 1 debut
Overall album sales boosted by holiday weekend
Michael Franti & Spearhead - "All People"
Featuring the first single, "I'm Alive [Life Sounds Like]"
Smashing Pumpkins - "Oceania: Live In NYC [2CD/DVD]"
Filmed in 3D in December 2012 at the Barclays Center


text: K first I have to say the taste is pretty awesome. A little sweet for my personal taste but still a good flavor of peach and tea. (one thing I do know is good tea). The label says to take 30 min before work out. But I would cut to 15 if on an empty stomach because I did that right at the end of shift before heading to the gym and in 15 min I was raring to go. Needless to say the drive to the gym was interesting. About half I got the tingle from beta alanine. This is one of the few prewo that I have actually gotten a a rush type feeling. Not overpowering but definitely there. Once at the gym I settled into my workout (chest day) had a nice energy through out. Didn't seem to wane at all. I left the gym with a nice pump in both my chest and tris. It's about three hours post wo and I still have a little pump in both. All around IMO great little prewo. Definitely on my Christmas wish list. If santa doesn't come through then I guess I'll have to buy a tub on my own. I'll try another flavor too.


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This Great British deck chair would suit a beach, balcony or back garden, anywhere in the UK. And it is made in England from sustainable beech so is built to last. There are too few things made in the UK now, but thankfully this deck chair is one of them.The colourway is red, white and blue with a contemporary beige stripe. The fabric is 100% cotton with no synthetics, so has a soft natural feel. Once you're in this deck chair, you're guaranteed to want to stay in it. The only thing that is not guaranteed is the great British weather!FREE delivery to the UK mainland for 2 or more deckchairs.
Please bear in mind that this deck chair fabric is 100% cotton with no synthetics. The modern dyes used today lack the toxic colour fasteners used in the past so they will fade if left out in strong sunlight or rain. Ideally this deck chair should be folded away after use and stored somewhere dry and well ventilated.
Delivery 3 - 5 days


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The story is told by Anya, the daughter of Russian parents living in exile in China. Her father is dead and the Japanese invasion and resulting Commun...
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Aresti Established in Chile's Curico Valley in 1951, Aresti Family Vineyards has been supplying top quality wine to other producers for 50 years. In the late 1990's the family began pursuing their own table wine program, bottling their best wines under the Aresti label. All wines are estate bottled.
Aresti produces two ranges of wine, the medium-bodied "A" range wines for everyday enjoyment, and the more intensely flavored Reserve wines. The "A" range includes a Chardonnay, Sauvignon Blanc, Merlot, Carmenere, and Cabernet Sauvignon. The Reserve range, made from grapes grown in the 'Rio Claro' sub-appellation of the Curico Valley, includes Merlot, Cabernet Sauvignon, Chardonnay, and Sauvignon Blanc.
Modern winemaking facilities, careful vineyard management, and a commitment to producing wines with a high quality/value relationship are the hallmarks of Aresti Family Vineyards.
Cabernet Sauvignon - With sweet and spicy aromas, this wine shows an open nose that blends candied aromas with sweet fruits. In the mouth it is well structured, with strong and round tannins providing volume and good persistence. A high concentration offers a pleasant finish
Carménère - Bright ruby color. On the nose the wine is open and intense with prominent floral aromas, figuring also grapes, figs, and raisins, intermingling with sweet and candied scents. Lively and fresh in the mouth with delicate toasted notes and a long lingering finish.
Merlot - Very deep and intense color. On the nose the wine is open and floral with notes of red fruits such as strawberry and raspberry, also figuring slight touches of fine leather. Sweet and soft in the mouth with hints of cacao aromas. Well-balanced with medium persistence.


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Series | Countries | Live Scores | Fixtures | Results | News |
Photos | Video & Audio | Blogs | Statistics | Archive | Games | Mobile |
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Indian cricket
Is there a way back for Sehwag?
Nov 27, 2013: Former India mental conditioning coach Paddy Upton, and former Test cricketers Dilip Vengsarkar and Chetan Chauhan on whether Virender Sehwag can break out of his rut
Mumbai v Delhi, Ranji Trophy, Group A, 2nd day, Mumbai
Gambhir, Manhas fifties propel Delhi
Nov 15, 2013: The second day of the Group A clash between Mumbai and Delhi was all about the "big three"- Virender Sehwag, Gautam Gambhir and Zaheer Khan
India news
No central contract for Zaheer, Sehwag
Nov 14, 2013: Zaheer Khan, Virender Sehwag and Harbhajan Singh find themselves out of contract for the 2013-14 season, while Gautam Gambhir and Yuvraj Singh find themselves downgraded in the BCCI's retainer list
Mumbai v Delhi, Ranji Trophy, Group A, Mumbai
Nov 13, 2013: Another opportunity for Sehwag, Gambhir and Zaheer to impress the selectors in a high-profile Ranji Trophy group game
Gujarat v Delhi, Ranji Trophy, Group A, Surat, 4th day
Delhi settle for draw after Sehwag flutter
Nov 10, 2013: Virender Sehwag failed for the second time in Surat after briefly promising a serious attempt to chase down the target of 257 runs in less than two sessions on the final day of the Group A game against Gujarat
India news
Sehwag, Zaheer a must in Tests - Ganguly
Oct 25, 2013: Sourav Ganguly, the former India captain, believes Zaheer Khan and Virender Sehwag should be handed Test comebacks, given the overseas challenges India have lined up next year
South Zone v North Zone, Duleep Trophy, final
Sehwag, Gambhir add heft to Duleep title clash
Oct 16, 2013: Duleep Trophy, the forgotten tournament that is often played in the background, has got a shot in the arm with Virender Sehwag and Gautam Gambhir joining the North Zone team for the final to be played in Kochi from Thursday onwards.
India A v WI A, 2nd unofficial Test, Shimoga, 2nd day
Gambhir and Sehwag fail for India A
Oct 3, 2013: The hosts' two batting stars tried to force the issue too early against spin and perished as they looked to make an impression on the selectors
India A v West Indies A, 2nd unofficial Test, Shimoga
Big-name trio in small-town venue
Oct 1, 2013: Virender Sehwag, Zaheer Khan and Gautam Gambir will plot their return to the national team in the biggest match Shimoga has hosted
India A v WI A, 2nd unofficial Test, Shimoga
Oct 1, 2013: Preparing for his first first-class game since being dropped from the Test side, Virender Sehwag gave everyone an injury scare in Shimoga
The overseas problems for Hafeez and other subcontinent openers
Sep 27, 2013: Many openers from the subcontinent have struggled overseas, but Mohammad Hafeez's stats are among the poorest
Delhi v India Blue, Challenger Trophy, Indore
Sehwag begins middle-order audition with quick fifty
Sep 26, 2013: A leaner Virender Sehwag came in at No. 4 for Delhi in their Challenger Trophy match against India Blue and produced a typically belligerent innings
Sehwag must resist middle-order temptation
Sep 22, 2013: His request to move down the order may not necessarily be beneficial for him or the team
How about Sehwag in the middle order?
Sep 13, 2013: He has always talked about how he would like to bat lower down. Perhaps he should be granted that wish now
West Indies A in India
Sehwag, Gambhir, Zaheer to play West Indies A
Sep 10, 2013: Virender Sehwag, Gautam Gambhir and Zaheer Khan have been picked to represent India A in two four-day games against West Indies A
Jun 3, 2013: Could there have been a ninth team in the Champions Trophy, made up of some exciting players overlooked for different reasons?
Sunrisers Hyderabad v Delhi Daredevils, IPL 2013, Hyderabad
Daredevils' struggles mirror Sehwag decline
May 4, 2013: Since the inception of the IPL, Sehwag has been a constant source of inspiration and big runs for Delhi Daredevils, but not this season
Delhi Daredevils v Mumbai Indians, IPL 2013, Delhi
Sehwag, Jayawardene trounce tricky target
Apr 21, 2013: On a hot Sunday afternoon, two bowling attacks got into a contest of who could get worse
India news
'Sehwag may have played his last game for India' - Boycott
Apr 11, 2013: Former England batsman Geoffrey Boycott said that India batsman Virender Sehwag may have played his last game for India
ICC Champions Trophy 2013
Sehwag, Harbhajan, and Zaheer not among Champions Trophy probables
Apr 6, 2013: Virender Sehwag, the India batsman, seamer Zaheer Khan, and offspinner Harbhajan Singh have not been included in the 30-man list of probables for the Champions Trophy to be held between June 6-23 in England this year
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Very well done and visionary it is true that knowledge and. Wisdom. Trumps. All!
Look at New 0rleans and the ten day response rate.
Chris, Becca & Adam have a seasoned, well-developed seminar model that has been honed over the years and combines teachings, breakouts, and exercises that will provide both critical insights and actionable ideas.
Specifically, this Rowe workshop offers
The connections made at these conferences have lasted between participants for years and are another significant benefit of the experience. For others, simply having the chance to engage with other highly successful people on these topics in a safe environment is worth the effort to attend.
In short, the goal of the weekend is for you to return home with peace of mind, knowing that you are equipped to meet the future head-on and prosper in it.
To learn more and register, click here.
Very well done and visionary it is true that knowledge and. Wisdom. Trumps. All!
Look at New 0rleans and the ten day response rate.
Here's hoping for a late season snow storm that blows in Friday nite after we've all arrived...since this former yankee turned Texan signed up for a winterized cabin~ :-)
Looking forward to meeting everyone,
My wife and I would love to attend the Peak Prosperity Weekend in Rowe, but sadly have a conflict in March. Is there another weekend planned this year? when?
we have a conflict that weekend. We live 30 minutes from Rowe so I'm bummed I can't make it. Please let us know if and when you schedule another weekend in the future. All the best!
Chris -
Any possibility that the major segments of the seminar could be recorded and offered for sale via the website? We would love to attend, but are a long way away (Missouri) and our efforts at resilience - keeping animals for meat, eggs, milk, etc - do not allow us much leeway in travel away from home.
Webinar? Podcast? In any case, thank you for all your efforts. Your site is a life-line for us.
Cheers. Jeff & Susan


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This section on health in the EU has been created as a trustworthy gateway to a wide range of information and data on health-related issues and activities at both European, national and international level. The content is produced by the European Commission, the Member States of the EU and the European Economic Area (EEA), plus EU candidate countries; by international organisations; and by pan-European non-governmental organisations in the area of public health.
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Dementia oecd.org
Dementia is a devastating condition for the people affected, their family and friends, and for health systems. Through its global reach and ability to bring together government and non-government per[...]New research centre on dementia opens its doors in London europa.eu
One million people in the world will be affected by dementia in 2020. If researchers have been hard at work looking for effective treatments, the existing ones will neither reverse nor stop the disea[...]Pinpointing the connection between diet and dementia europa.eu
Alzheimer's disease is a degenerative disorder affecting between 50 percent and 70 percent of all dementia sufferers. As neurons are killed slowly yet progressively, sufferers experience memory loss [...]Research seminar on early childhood education and care: long-term outcomes for children and impact on parents' labour market participation europa.eu
On 4 December, the Social Situation Monitor (SSM) is organising a seminar where experts, researchers and officials will meet to discuss early childhood education and care.[...]Scientific guideline: Draft concept paper on need for revision of the guideline on medicinal products for the treatment of Alzheimer's disease and other dementias, draft: consultation open europa.eu
The proposed guideline will replace `Guideline on medicinal products for the treatment of Alzheimer's disease and other dementias' (CPMP/EWP/553/95 Rev. 1)[...]Comments invited on concept paper on the need to revise the guideline on medicines to treat Alzheimer's disease europa.eu
The European Medicines Agency has released a concept paper on the need to revise the guideline on medicines for the treatment of Alzheimer's disease and other dementias for public consultation.[...]A good life in old age? - Just Published - EU Bookshop europa.eu
Monitoring and improving quality in long-term care[...]UNFPA - Sixth Asian and Pacific Population Conference to Set Population Agenda for Building Better Lives unfpa.org
The five-day Conference is expected to arrive at fresh solutions to address these population and development challenges. Organized by the United Nations Economic and Social Commission for Asia and t[...]Sweden- Early-Onset Dementia Linked To Alcohol (18.09.13) eurocare.org
In this nationwide cohort study, researchers identify nine risk factors for dementia that could be traced to adolescence, suggesting strong opportunities for early intervention. Read more[...]UNFPA - Sixth Asian and Pacific Population Conference to Set Population Agenda for Building Better Lives unfpa.org
The five-day Conference is expected to arrive at fresh solutions to address these population and development challenges. Organized by the United Nations Economic and Social Commission for Asia and t[...]The Burden of Constipation in our Ageing Population eugms.org
On 12th February 2013 a multi-disciplinary, pan-European group of representatives, identified by the International Longevity Centre-UK (ILC-UK) and Norgine, met in Brussels to discuss and consider an[...][EU Commission report] Health inequalities in the EU. Gaps in life expectancy and infant mortality narrow; unequal progress and gradient prevalent epha.org
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Cyclic vomiting syndrome
By Mayo Clinic staffOriginal Article: http://www.mayoclinic.com/health/cyclic-vomiting-syndrome/DS00835
Cyclic vomiting syndrome is characterized by episodes of severe vomiting that have no apparent cause. Episodes can last for hours or days and alternate with relatively symptom-free periods of time. Each episode is similar to previous ones, meaning that episodes tend to start at the same time of day, last the same length of time and occur with the same symptoms and level of intensity.
Once thought to affect only children, cyclic vomiting syndrome occurs in all age groups. Research suggests that cyclic vomiting syndrome may affect almost 2 percent of school-age children and that the number of cases diagnosed in adults is increasing.
Cyclic vomiting syndrome may be related to migraines. Episodes can be so severe that the person has to stay in bed for days.
The syndrome is difficult to diagnose because vomiting is a symptom of many disorders. Treatment generally involves managing symptoms and lifestyle changes to help prevent the events that can trigger vomiting episodes. Medications, including anti-nausea and migraine therapies, may help lessen symptoms.
The symptoms of cyclic vomiting syndrome include:
- Severe vomiting that occurs several times per hour and lasts less than one week
- Three or more separate episodes of vomiting with no apparent cause in the past year
Other symptoms during a vomiting episode may include:
- Abdominal pain
- Diarrhea
- Fever
- Dizziness
- Sensitivity to light
The intervals between vomiting episodes are generally symptom-free. But some people experience mild to moderate nausea or abdominal or limb pain between episodes.
Continued vomiting may cause severe dehydration that can be life threatening. Symptoms of dehydration include:
- Thirst
- Less urination
- Paleness
- Exhaustion and listlessness
The cause of cyclic vomiting syndrome is unknown. But the bouts of vomiting that characterize the syndrome can be triggered by:
- Colds, allergies or sinus problems
- Emotional stress or excitement, especially in children
- Anxiety or panic attacks, especially in adults
- Foods, such as chocolate or cheese
- Overeating or eating right before going to bed
- Hot weather
- Physical exhaustion
- Menstruation
- Motion sickness
Identifying the triggers for vomiting episodes may help with managing cyclic vomiting syndrome.
Risk factors
The relationship between migraines and cyclic vomiting syndrome isn't clear. But many children with cyclic vomiting syndrome have a family history of migraines or have migraines themselves when they get older. In adults, the association between cyclic vomiting syndrome and migraine may be lower.
Chronic use of marijuana (cannabis sativa) also has been associated with cyclic vomiting syndrome.
Cyclic vomiting syndrome can cause these complications:
- Dehydration. Excessive vomiting causes the body to lose water quickly. Severe cases of dehydration may need to be treated in the hospital.
- Injury to the food tube. The stomach acid that comes up with the vomit can damage the tube that connects the mouth and stomach (esophagus). Sometimes the esophagus becomes so irritated it bleeds.
- Tooth decay. The acid in vomit can corrode tooth enamel.
Preparing for your appointment
You're likely to start by seeing your primary care doctor or your child's pediatrician. But you may be referred immediately to a digestive diseases specialist (gastroenterologist). If you or your child is in the middle of a severe vomiting episode, the doctor may recommend immediate medical care.
Here's some information to help you get ready for your appointment and know what to expect from the doctor.
What you can do
- Keep a record of any symptoms, including how often vomiting occurs and any typical triggers you may have noticed, such as food or activity.
- Write down key medical information, including other diagnosed conditions.
- Write down key personal information, including dietary habits and any major stresses or recent changes — both positive and negative — in your child's life or yours.
- Bring a list of all medications, as well as any vitamins or supplements, that you or your child takes.
- Write down questions to ask the doctor.
Questions to ask the doctor
Some basic questions to ask the doctor include:
- What is the most likely cause of these symptoms?
- Are any tests needed?
- Do you think this condition is temporary or long lasting?
- What treatments do you recommend?
- Is there a medication that can help?
- Are there any dietary restrictions that can help?
Don't hesitate to ask other questions.
What to expect from the doctor
Be ready to answer questions your doctor may ask:
- When did you or your child begin experiencing symptoms?
- How often does an episode of severe vomiting occur, and how many times do you or does your child typically vomit?
- How long do the episodes typically last?
- Do you or does your child experience abdominal pain?
- Have you noticed any warning signs that an episode is coming, such as loss of appetite or feeling unusually tired, or any common triggers, such as intense emotions, illness or menstruation?
- Have you or has your child been diagnosed with any other medical problems, including mental health conditions?
- What treatments, including over-the-counter medications and home remedies, are you or your child taking for other conditions?
- Does anything seem to improve the symptoms or shorten the duration of an episode?
- Do you or does your child have any history of severe headaches?
- Does anyone in your family have a history of cyclic vomiting syndrome or of migraines?
What you can do in the meantime
The doctor will likely want to see you or your child immediately if an episode of severe vomiting is underway. But if the vomiting has passed, recovery will be aided by getting lots of rest, increasing intake of fluids and following an easy-to-digest diet. It's also a good idea to avoid caffeinated beverages or foods containing caffeine.
Tests and diagnosis
Cyclic vomiting syndrome can be difficult to diagnose. There's no specific test that will confirm the diagnosis, and vomiting is a sign of many diseases and disorders that must first be ruled out.
The doctor will start by asking about your child's or your medical history and conducting a physical exam.
After that, the doctor may recommend:
- Imaging studies — such as endoscopy, CT scan or magnetic resonance enterography — to check for blockages in the digestive system or signs of other digestive conditions
- Motility tests to monitor the movement of food through your digestive system and to check for digestive disorders
- Laboratory tests to check for thyroid problems and other metabolic conditions
- MRI to check for a brain tumor and other central nervous system disorders
Treatments and drugs
There's no cure for cyclic vomiting syndrome, so treatment focuses on controlling the signs and symptoms. You or your child may be prescribed:
- Anti-nausea drugs
- Sedatives
- Medications that suppress stomach acid
- Antidepressants
The same types of medications used for migraines can sometimes help stop or even prevent episodes of cyclic vomiting. These medications may be recommended for people whose episodes are frequent and long-lasting.
Behavioral therapy
Research indicates that almost half the people with cyclic vomiting syndrome also have depression or anxiety. But the extent to which depression and anxiety cause cyclic vomiting or result from cyclic vomiting isn't clear. Your child's doctor or yours may recommend behavioral therapy to help with any depression or anxiety.
Lifestyle and home remedies
Lifestyle changes can help control the signs and symptoms of cyclic vomiting syndrome. People with cyclic vomiting syndrome generally need to get adequate sleep. Once vomiting begins, it may help to stay in bed and sleep in a dark, quiet room.
When the vomiting phase has stopped, it's very important to drink water and replace lost electrolytes. Some people may feel well enough to begin eating a normal diet soon after they stop vomiting. But if you don't or your child doesn't feel like eating right away, you might start with clear liquids and then gradually add solid food.
If vomiting episodes are triggered by stress or excitement, try during a symptom-free interval to find ways to reduce stress and stay calm. Eating three small meals and three snacks daily, instead of three large meals, also may help.
Alternative medicine
Alternative and complementary treatments may help prevent vomiting episodes, although none of these treatments has been well studied. These treatments include:
- Biofeedback training to learn techniques for managing stress, which can trigger vomiting episodes.
- L-carnitine, a natural substance that is made in the body and is available as a supplement. L-carnitine helps your body turn fat into energy.
- Coenzyme Q10 (ubiquinone), another natural substance made in the body that is available as a supplement. Coenzyme Q10 assists with the basic functions of cells.
L-carnitine and coenzyme Q10 may work by helping your body overcome difficulty in converting food into energy (mitochondrial dysfunction). Some researchers believe mitochondrial dysfunction may be a factor causing both cyclic vomiting syndrome and migraine.
Always check with your doctor before taking any supplements to be sure you or your child is taking a safe dose and that the supplement won't adversely interact with any medications you're taking. Some people may experience side effects from L-carnitine and Coenzyme Q10 that are similar to the symptoms of cyclic vomiting syndrome, including nausea, diarrhea and loss of appetite.
Coping and support
Because you never know when the next episode might occur, cyclic vomiting syndrome can be difficult for the whole family. Children may be especially concerned, and may worry constantly that they'll be with other children when an episode happens.
You or your child may benefit from connecting with others who understand what it's like to live with the uncertainty of cyclic vomiting syndrome. Ask your doctor about support groups in your area.
Many people know what triggers their cyclic vomiting episodes. Avoiding those triggers can reduce the frequency of episodes.
If episodes occur more than once a month or require hospitalization, your doctor may recommend preventive medicine. Lifestyle changes also may help, including:
- Getting adequate sleep
- Downplaying the importance of upcoming events because excitement can be a trigger
- Avoiding trigger foods, such as cheese and chocolate
- Eating three small meals and three snacks daily at regular times
Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2010. http://www.mdconsult.com/books/about.do?eid=4-u1.0-B978-1-4160-6189-2..X0001-7--TOP&isbn=978-1-4160-6189-2&about=true&uniqId=229935664-2192. Accessed Feb. 15, 2013.
- Choung RS, et al. Cyclic vomiting syndrome and functional vomiting in adults: association with cannabinoid use in males. Neurogastroenterology & Motility. 2012;24:20.
- Cyclic vomiting syndrome. National Digestive Diseases Information Clearinghouse. http://digestive.niddk.nih.gov/ddiseases/pubs/cvs/index.aspx. Accessed Feb. 18, 2013.
- Kumar N, et al. Cyclic vomiting syndrome (CVS): Is there a difference based on onset of symptoms - pediatric versus adult? BMC Gastroenterology. 2012;12:52.
- Drumm BR, et al. Cyclical vomiting syndrome in children: A prospective study. Neurogastroenterology & Motility. 2012;24:922.
- Kliegman RM, et al. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, Pa.: Saunders Elsevier; 2011. http://www.mdconsult.com/das/book/body/208746819-6/0/1608/0.html. Accessed Feb. 18, 2013.
- Hejazi RA, et al. Review article: Cyclic vomiting syndrome in adults - rediscovering and redefining an old entity. Alimentary Pharmacology & Therapeutics. 2011;34:263.
- AskMayoExpert. When should patients with nausea and vomiting be referred for subspecialty evaluation? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2012.
- Longo DL, et al. Harrison's Principles of Internal Medicine. 18th ed. New York, N.Y.: McGraw-Hill; 2012. http://www.accessmedicine.com/content.aspx?aID=9112783. Accessed Feb. 15, 2013.
- Slutsker B, et al. Breaking the cycle: Cognitive behavioral therapy and biofeedback training in a case of cyclic vomiting syndrome. Psychology, Health & Medicine. 2010;15:625.
- Boles RG. High degree of efficacy in the treatment of cyclic vomiting syndrome with combined co-enzyme Q10, L-carnitine and amitriptyline, a case series. BMC Neurology. 2011;11:102.
- Rakel D. Integrative Medicine. 3rd ed. Philadelphia, Pa.: Saunders Elsevier; 2012. http://www.mdconsult.com/das/book/body/208746819-2/0/1494/0.html. Accessed March 3, 2013.
- Hoecker JL (expert opinion). Mayo Clinic, Rochester, Minn. March 4, 2013.


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Progressive Party (West's Encyclopedia of American Law)
Beginning in the 1900s, the political history of the United States has been the story of the two mainstream political parties, the Democrats and the Republicans, and the third party movements that have grown and receded in their wake. Between 1912 and 1948, progressivism, a broadly based reform movement, had three national incarnations as the Progressive Party.
Progressivism began as a response to the transformation of American society from an agricultural-based economy to an industrial one. Many American workers, both native-born and immigrant, found themselves hindered by long hours of work in dangerous conditions, low pay, and unsafe and unsanitary housing. Reformers in the largest cities began to lobby for safer working environments, improved tenement housing, and public ownership of utilities. Others fought political corruption and the cronyism that was part of the established political machines of both parties.
In 1908, President THEODORE ROOSEVELT, who had sought to find a balance between capitalists and working people and had gained fame as the nation's chief "trustbuster," declined to run for another term. With Roosevelt's support, his friend and colleague WILLIAM HOWARD TAFT was elected president, a move that at first was hailed by a number of Progressives. The conservative Taft turned out to be a huge disappointment to the Progressives and to Roosevelt, who...
(The entire section is 860 words.)
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Welcome to the Computational Creativity Group (CCG) of the Department of Computing, Imperial College London, UK.
We conduct Artificial Intelligence research into the development and combination of AI systems for creative tasks. We use this research to address interesting practical and philosophical questions about what it means for software to be autonomously creative.
We are interested in computational creativity in both the arts and sciences. In particular, we have undertaken projects with applications to pure mathematics, graphic design, video game design and the visual arts.
Please see our overview page to find out: What is Computational Creativity?
If you have any questions about the research in the group, please email the relevant group member, or for general enquiries, please email Simon Colton (firstname.lastname@example.com).
The BBC's Horizon series' latest issue focused on 'The Hunt For AI', which included a segment on Simon Colton's Painting Fool project (and Simon himself). The episode is available until the 17th April on the BBC iPlayer here.
The Shibumi Rule Book has been released by Cameron and project partner Nestor Romeral Andres, as part of the EPSRC project "UCT for Games and Beyond". This book is a collection of the best known games for the Shibumi set, which will be used as raw material for an upcoming experiment on automated game design.
ANGELINA and Mike are on the New Scientist website, having developed a platform game based on our Metroidvania work especially for the magazine. You can read the article here.
An i09 article on The Painting Fool has been published here. The reader comments are quite enlightening… Also, the Daily Mail has an article on The Painting Fool here.
ANGELINA and Mike have been featured in a two-page article in Develop magazine, a games industry publication in print and online. You can read the full issue here (article on page 44) and the article itself here.
Our work with The Painting Fool project has been extensively covered (with pictures!) in a New Scientist article for the week starting 14th January. Here is a local PDF, and the online version of the article, with a video, is available here: Creative Sparks. There is also an online gallery here: Gallery and a TV blog article here. See also the webpages for The Painting Fool.
Simon Colton is giving a Whitehead Lecture on 18th January at Goldsmiths College. The talk is entitled: "Computational Creativity in a post-Turing Test World". An abstract is available on our events web page.
Alison Pease and Flaminia Cavallo join the group! They will be undertaking research on the Computational Creativity Theory project.
We have been awarded a £1m EPSRC Leadership Fellowship, to study "Computational Creativity Theory over five years". See the departmental announcement for details.
Simon Colton and Cameron Browne win a £1.5 million EPSRC grant to investigate "UCT for Games and Beyond", a joint project with the Universities of Essex and Bradford to be run over three years.
Robin Baumgarten's Mario Bot wins the first round of the 2010 competition, prompting the question from the competition organiser, Julian Togelius: "can anyone beat Robin's bot?"
Chong-U Lim's paper "Evolving Behaviour Trees for the Commercial Video Game DEFCON" is nominated for a best paper prize at EvoGames 2010.
Please also see our News Archive…
Evolutionary Game Design (IEEE CIG 2011)
Search-based Procedural Content Generation: A Taxonomy and Survey. (IEEE CIG 2011)
Multi-Faceted Evolution Of Simple Arcade Games (CIG 2011)
Towards MCTS for Creative Domains (ICCC 2011)
Computational Creativity Theory: The FACE and IDEA Descriptive Models (ICCC 2011)
Computational Creativity Theory: Inspirations behind the FACE and the IDEA models (ICCC 2011)
The Painting Fool in New Dimensions (ICCC 2011)
Automated Collage Generation – With More Intent (ICCC 2011)
On Impact and Evaluation in Computational Creativity (AISB 2011)
Ludic Considerations of Tablet-Based Evo-Art (EvoMusArt 2011)
Stroke Matching for Paint Dances (Computational Aesthetics 2010)
Capturing Player Experience with Post-Game Commentaries (CGAT 2010)
Using automated theory formation to discover invariants of Event-B models (Rodin 2010)
Capturing Player Experience with Post-Game Commentaries (CGAT 2010)
Player classification using a meta-clustering approach (CGAT 2010)
Automatic Generation of Dynamic Investigation Problems (ARW 2010)
Applying the GC Combined Reasoning Framework to Mathematical Discovery (AISB 2010)
Evolving Pixel Shaders for the Prototype Video Game Subversion (AISB 2010)
Towards Automatic Player Behaviour Characterisation using Multiclass LDA (AISB 2010)
Evolving 3D Buildings for the Prototype Video Game Subversion (EvoGames 2010)
Evolving Behaviour Trees for the Commercial Game DEFCON (EvoGames 2010)
Search Based Procedural Content Generation (EvoGames 2010)
Experiments in Objet Trouve Browsing (ICCC 2010)
Automated Collage Generation - With Intent (ICCC 2010)
The Painting Fool Teaching Interface (ICCC 2010)


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Police concerned for welfare of escaped convict (From Bromsgrove Advertiser)
Get involved! Send your photos, video, news & views by texting BA NEWS to 80360 or e-mail us
Officers fear for mental state of Alan John Giles who fled prison near Redditch
2:41pm Wednesday 30th October 2013 in News
POLICE have made a direct appeal to a convicted child killer from the West Midlands to hand himself in after he absconded from prison while serving two life sentences for kidnap and murder.
Alan John Giles, 56, fled from an "open" section of HMP Hewell, near Redditch, Worcestershire, on Monday, West Mercia Police said.
Giles, originally from Oldbury, was jailed in 1997 at Birmingham Crown Court for murdering 16-year-old Kevin Ricketts in 1995.
At the time of Giles' trial, the body of the victim, a student from Quinton, near Birmingham, had not been found.
Chief Inspector Paul Judge of West Mercia Police said today: "We are concerned as Giles has been missing since Monday morning and we are urging the public to help us find him as soon as possible by reporting any sightings of him immediately.
"We are concerned about his state of mind as a result of information we have received after he went missing and I would like to take this opportunity to appeal to him to hand himself in directly to the nearest police station or contact us by phone so that we can resolve this matter."
Appealing for the public's help to trace Giles, Detective Inspector John Cashion, of West Mercia Police, said: "We have a dedicated investigation team working expeditiously to locate and apprehend Giles and to that end we are also liaising with our colleagues in West Midlands Police and in the Prison Service.
"We have information that gives us concern for his welfare and it is important that we trace him as soon as possible.
"It should be borne in mind that Giles was in an open part of the prison when he went missing.
"However we would appeal to anyone who sees him not to approach him but to contact police immediately on 999.
"Furthermore, we would urge anyone who may be helping him or sheltering him to contact us without delay."
Giles, who has had recent contact with family in the West Midlands, is described as white, 5ft 9ins, and of proportionate build with short grey hair and blue eyes.
He has tattoos of an eagle on his back and a swallow, shark and flower on his left arm.
It is believed Giles is wearing a grey Rockport sweater, blue jeans and white Asics trainers.
Kevin's body was found in 1998, buried in the garden of a property in Edgbaston, Birmingham, after Giles was interviewed by detectives while serving his sentence.
Giles, a former labourer, killed the teenager in an apparent revenge attack after his victim's elder sister ended their relationship.
Kevin is believed to have been abducted while en route to classes at South Birmingham College in January 1995, shortly after leaving his home.
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"The cost of victory is blood, the cost of defeat is everything."
–The Empire at War
Set amid the constant warfare of the Old World, Warhammer: Diskwars is a game of ferocious, fast-paced tabletop battles for two to four players. At the heart of the game's conflicts are its disks, which represent heroes and units from across the Old World. During the game, you activate these disks, flipping them end over end to move them across the battlefield and position them to attack.
With a host of terrain cards, objectives, command cards, and more than sixty disks for the game's four races, the Core Set...
© Games Workshop Limited 2013. Games Workshop, the Games Workshop logo, Warhammer, the Warhammer logo, the foregoing marks' respective logos and all associated marks, logos, places, names, creatures, races and race insignia/devices/logos/symbols, vehicles, locations, weapons, units and unit insignia, characters, products and illustrations from the Warhammer World are either ® or ™, and/or © Games Workshop Ltd 2000 - 2013, variably registered in the UK and other countries around the world. This edition published under license to Fantasy Flight Publishing Inc. Diskwars and Fantasy Flight Supply are trademarks of Fantasy Flight Publishing, Inc. Fantasy Flight Games and the FFG logo are registered trademarks of Fantasy Flight Publishing, Inc. All rights reserved to their respective owners.


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Geami @ Anthropologie in Ohio
For those of you who don't know about Geami (ge-ah-me) it is an eco-friendly alternative to bubble wrap and other packing materials. Artist, Roni Callahan got creative with it at this in-store display at Anthropologie in Westlake, Ohio. We love … Continue reading
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Tagged Anthropologie, artt in window, geami, green wrap, packaging, sculpture
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Name | Chris Bishop |
Job Title | Founder & CEO |
Organization | 7thingsmedia |
Subscription Level | Small Business Multi-user |
Registered Since | 26 Jul 2004 |
Areas of Expertise | Affiliate Marketing, Ecommerce, Organic/Natural Search (SEO), Paid Search (PPC), Strategy & Operations |
Contact Details |
Telephone: 02070173190Address: 7thingsmedia, 18/20 St. John Street, London, EC1M4NX, United Kingdom |
About Me
Chris began his career in online media in 1999 as publisher and owner of an online sports network, from there he was one of four people to graduate in the UK's first e-business degree. From there he held acquisition roles at Johnson & Johnson, TradeDoubler, Hotel Chocolat and House of Fraser before setting up 7thingsmedia in April 2009.
Under the expert leadership of Chris, 7thingsmedia has been named "Best Agency" for three consecutive years at the Performance Marketing Awards. The London & New York-based agency consistently delivers outstanding results and triple digit growth on behalf of global "superbrand" clients including boohoo.com, MARS and Ted Baker.
Chris holds a plethora of accolades acknowledging his contribution to online marketing, including the prestigious title of "Marketer of the Year" from The Drum and a place in VOGUE.com's 100 Most influential People in Online Fashion.
As a lecturer for Econsultancy, Chris trains the next generation of digital gurus, he is a true leader in the field of digital.
My Links
Award-winning global digital media agency. Services include: affiliates, display, lead generation, mobile, PPC, SEO & social media.
Blog posts and comments by Chris Bishop
- The future of SEO was PR, is it CRO now?, 23 Aug 2013
- The future of SEO was PR, is it CRO now?, 22 Aug 2013
- The future of SEO was PR, is it CRO now?, 21 Aug 2013
- This post is not affiliated with my employers, 14 Aug 2013
- Seven quick tips for success with localised SEO, 17 Jun 2013
- Seven quick tips for success with localised SEO, 14 Jun 2013
- Seven quick tips for success with localised SEO, 14 Jun 2013
- The value of affiliate marketing today, 2 Jul 2012
- Seven tips for global e-commerce, 22 Mar 2012
- 40% of leading UK fashion brands run out of PPC budget before end of day, 28 Feb 2012
Forum posts by Chris Bishop
- Affiliate Marketing in America, 10 Jun 2011
- Help with affiliate network/link building, 26 Oct 2009
- Mydeco pay per click?, 26 Oct 2009
- Help selecting affiliate network provider, 19 Jul 2009
- Preventing multiple payments when using multiple affiliate programmes, 13 Aug 2008


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So I posted a thread lastnight looking for help on a problem I ran into. Since then I found a better way I could do it an I almost have it where I want it but need a little help. Here a quick rundown.
As the title says this is basically my problem. In my application I have a feature to add breakpoints/bookmarks in the textbox that the user is inputting information into. As they add the breakpoint it adds the line number that the item is on and also the contents of that line to a listview. Line number in first column line content goes in the second column. So now I have added multiple document abilities in the application so I devised a way to have it clear the listview on tab change and re- add all breakpoints that are in the current textbox.
The only problem is that it only works for the first breakpoint added. Then I get an error stating something along the lines that the number three cant be added more than once please remove it or clone it. Im thinking I have something wrong with the multiple loops. Maybe I need to change the location of the loops?
Anyways if someone could look at it and tell me what is wrong I would appreciate it.
vb Code:
Private Sub page_TabIndexChanged(ByVal sender As System.Object, ByVal e As System.EventArgs) For Each lvitem As ListViewItem In ListView1.Items lvitem.Remove() Next Dim breaklist As New ListViewItem Dim page As RadPageViewPage = RadPageView1.SelectedPage For Each txt As FastColoredTextBox In page.Controls.OfType(Of FastColoredTextBox)() For i As Integer = 0 To bookmarks.Count - 1 Dim id As Integer = bookmarks(i) Dim boom As String For f As Integer = 0 To txt.LinesCount - 1 If txt(f).UniqueId = id Then breaklist.Text = CStr((f + 1)) boom = txt.GetLineText(f) breaklist.SubItems.Add(boom) ListView1.Items.Add(breaklist) End If Next Next Next End Sub


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Foreigner #10
C. J. Cherryh - Author
ISBN 9781101549780 | 400 pages | 04 May 2010 | DAW | 18 - AND UP
Summary of Conspirator
Summary of Conspirator
Reviews for Conspirator
An Excerpt from Conspirator
First in a brand-new Foreigner trilogy from Hugo Award winning author C. J. Cherryh.
Cajeiri is the young son of the powerful leader of the Western Association-and he has become a target for forces bent on destroying his father's rule. For Cajeiri is the first ateva youth to have lived in a human environment. And after hundreds of years of fragile atevi-human coexistence, he may very well be the first of his people to ever truly understand the so similar-yet so dangerously different-aliens who share his home planet and threaten the hidebound customs of his race. |
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Devil's Crossroad is a Role Playing Game set in the gritty and exciting world of the American Old West.
Charcters will square off with deadly gunfighters, ruthless bounty hunters, and the harsh western frontier.
This 93 page PDF gives you all you need to chracter characters and run games in Devil's Crossroad.
Devil's Crossroad 2e is a pen and paper role playing game set in the exciting world of the American Wild West.
Create a cowboy, a lawman, a prospector, a gambler, or any other character you can imagine. The trail to adventure is waiting.
The core rules are here for creating characters and running the game, character sheets, a preview of the Burning Plains setting, and a ch... [click here for more]
Keep track of all the important information about your character with this official Devil's Crossroad second edition character sheet.
check out the Devil's Crossroad facebook page
Forget what you can use determination for mid fight? wondering how much damage the first aid skill recovers? need a quick weapon for an NPC?
The GM's Aid is a handy one page collection of some of the most important rules needed to run a combat encounter in Devil's Crossroad second edition.
Need a horse? This one page GMs aid offeres rules for mounts for GMs who need stats for horses and mounts on the the fly.
Is your character a talker? Need to know what skills can be used for a first impression? perhaps you need the rules for playing a hand of cards. This free GM Aid has many of the more common and overlooked rules for social interaction and rules for social skills.
Deadly Outlaws roam the Burning Plains. Some are vile and evil, others are simply desperate. The ruthless Alexander Justice, folk heroes the Jackson Brothers, the brutal Ezekiel Trapper, the deceptive Bonnie Carpenter. These outlaws might make deadly enemies of any group of players, or become strange allies to those willing to ride beyond law and order.
The Burning Plains is an area full of conflict and adventure. Powerful business interests attempt to carve out civilization from a frontier, Native American's struggle for their survival, ruthless outlaws are steal and murder below the western sun, and a handful of lawmen try to maintain order in a chaotic wilderness.
The Burning Plains is not a place for the weak or the careless.... [click here for more]
Tools for running games of Devil's Crossroad.
Includes expanded skills as well as options for more cinematic games, exotic and finely crafted weapons, guidelines for making NPCs on the spot, suggestions for adventures and settings, and a sample setting to get you started.
Create the character you've always wanted. Expanded rules for character creation make it possible to create even more varied characters. New story based character creation method merges the character's history with their stats so that each stage of the character's life is reflected in their stats and scores.
Keep track of all this information with a deluxe, 3 page c... [click here for more]
Complete character sheet to keep track of your Devil's Crossraod characters.
"The dog may be man's best friend, but the horse wrote history"
Introduces rules for Animal Companions for Devil's Crossroad. Create valued friends for your character in the form of faithful dogs and loyal horses.
Expanded rules for horses and horsemanship.
A complete Old West saloon. Complete with NPC's, adventure hooks, and bar games.
The Morningstar might be the base of operations for the players or just a place to come in for drinks. When the drinks are flowing and the cards are on the table, who knows what will happen?
Keep track of NPC information on this NPC Sheet.
Sheet contains space for two NPCs
Get Started!
Quick Draw is a free demo for Devil's Crossroad. A game of regular men and women trying to make it the harsh and unfriendly Old West.
Quickdraw gives you everything you need to create character and the basic rules of the system.
Devil's Crossroad Second Edition is coming.
The Old West. A vast wilderness was giving way to settlement. The bold could become wealthy, the unlucky might not live to see tomorrow. Outlaws, Cowboys, Gun Slingers, Bounty Hunters, Lawmen. Which Path will you take? It's a Devil's Crossroad.
This is the first of three previews, to give players who are familia... [click here for more]
This is the second of three previews, to give players who are famili... [click here for more]
This is the third and last preview of the new edition. It give playe... [click here for more]
The Burning Plains is a campaign setting for Devil's Crossroad.
Explore the endless plains, winding rivers, dense forests, and looming mountains of the old west. Visit boomtowns and thriving cities, or venture into deserted ghost towns where secrets may be buried.
Gunfigh... [click here for more]
The Grave of Reyes is an adventure meant to introduce players and game masters to Devil's Crossroad.
A band of outlaws have descended upon what they thought would be an empty ghost town looking for a buried treasure.
Includes expanded skills as well a... [click here for more]


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Okay, so how do I successfully connect the support ring of the Red 300mm to the Red universal mount? They miss each other by like an inch or more.
What is the preferred method? It seems silly for Red to sell me a 300mm lens that has a lens support ring, and a universal mount, that then don't work together.
Am I missing something?


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* iTunes support * Can use your own headphones * Bluetooth
* 100 song iTunes limit * No Bluetooth stereo support
Whats in the Box: ROKR E1 handset, Battery, and Home charger. Manufacturer Product Description Introducing iTunes for your mobile phone. With iTunes on your Motorola ROKR E1, you can listen to music on your mobile phone, wherever, whenever you want.
It Rings and Sings With iTunes for your mobile phone, your songs live right alongside your contacts. Think of it as musical multitasking. Hear a selection of your favorite tunes while sending text messages, taking pictures or checking your email. Listen through headphones or out loud on the ROKR E1s speakers. You can even pause the music when your phone rings, so you wont miss incoming calls.
As Easy As It Sounds The ROKR E1s handy menu interface lets you scroll through your playlists, select a song and play it--complete with any accompanying album art. Putting your music on the ROKR E1 is as easy as syncing to iTunes, the worlds best digital jukebox. Just connect the ROKR E1 to your Mac or PC, then choose the songs you want to sync or let iTunes choose them for you--autofilling your phone with a random selection from your iTunes music library.
* Install iTunes desktop software * Connect the phone to your PC or MAC * Drag and drop songs - pick the songs you want or let iTunes do it for you
* Use the iTunes key on your phone to access your music * Shuffle songs or select a song, artist or playlist - just like iTunes * Get stereo sound through the phones speakers or the included ear buds
Never Miss a Beat
* Pause music when you need to take a call * Resume play automatically once you hang up * Listen to music while browsing the internet, sending and receiving messages, even while taking pictures
Product Features
* The first phone to feature Apple iTunes software * Micro-SD (Transflash) Memory Card slot * Built-in VGA camera w/ Video Recording capability * Easy file transfer with USB connectivity * Bluetooth Technology for convient hands-free use
* Size (LWH): 3.43 inches, 1.75 inches, 0.91 inches * Weight: 3.26 pounds
* Network Compatibility: GSM * Phone Book Capacity: 100 Entries * Minimum Rated Talk Time: 360 minutes * Minimum Rated Standby Time: 250 hours * Battery Type: Lithium Ion


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The mission of the Laboratory of Virology is to achieve a clear understanding of immune correlates and mechanisms of protection against primary HIV infection. Our efforts focus on understanding the cellular and molecular regulation of viral gene expression, entry into the cell, and correlates of immune protection. Our primary objective, in collaboration with the structural biology and virology laboratories, is to utilize genetic mutations and immunologic assessment in order to develop immunogens that elicit broadly neutralizing antibodies to HIV with the goal of developing safe and effective AIDS vaccines. Our major areas of investigation involve the human immunodeficiency virus (HIV) and emerging viruses such as Ebola. Other areas of study address mechanisms of viral gene regulation and provide insight into the regulation of eukaryotic gene expression.
The mission of the Vector Core Laboratory is to design CTL-based HIV vaccine candidates by preparing gene-based immunogens. HIV cDNAs are inserted into relevant plasmids in order to produce effective immunogens that induce CTL. Various cDNAs have been tested using plasmid-based gene delivery, and selected candidates that express either Gag, Pol, various Gag-Pol fusion proteins and mutants, as well as Env and Nef cDNAs, have also been inserted into viral vectors. These vectors include replication-defective forms of adenoviruses and poxviruses. The viral genes include both clade B and non-clade B viruses. Gene-based immunogens are modified to improve protein expression and immunogenicity. These approaches provide great flexibility in identifying immunogens that can induce broad and potent CTL immune responses.
The BSL3 Core Virology Laboratory will accommodate Vaccine Research Center (VRC) laboratory work requiring level 3 biosafety containment. The laboratory will produce and characterize viral stocks of SIV and HIV, including diverse viral strains representing multiple genetic subtypes. The laboratory also performs studies of antibody-mediated neutralization of HIV and SIV, with a focus on primary virus strains and physiologically relevant target cells. As accurate measurement of neutralization of primary HIV-1 strains is important for the evaluation of immune responses to candidate vaccines, high throughput assays will evaluate neutralizing antibody levels in serum from preclinical and clinical vaccine studies.
The goal of the Cellular Immunology Section is to develop vaccines for infectious diseases in which the cellular immune response is required to mediate protection (e.g., Leishmania major, Mycobacterium tuberculosis, HIV). In this regard, the major focus of the laboratory is to understand the cellular and molecular mechanisms by which various cytokines and costimulatory molecules regulate cellular immunity in vivo. Moreover, a particular emphasis is directed toward how memory Th 1 responses are regulated.
The Clinical Trials Core will perform Phase I trials of candidate HIV vaccines developed by the VRC. This will involve community education on HIV prevention, recruitment of healthy adults into clinical trials, study design and analysis, and maintenance of regulatory standards. The Clinical Studies Core will also conduct studies of the natural history of HIV infection and evaluate basic aspects of pathogenesis, antigen presentation, and immune response. In addition, other vaccine candidates developed by VRC investigators for agents other than HIV will be evaluated in clinical trials.
The mission of the Flow Cytometry Core Laboratory is to support the flow cytometry needs of the VRC research laboratories and the VRC clinical trials, as well as to bring in or develop new flow-based assays and technologies to support these efforts. The Flow Cytometry Core Laboratory maintains and operates a range of instruments, from basic benchtop analyzers to the most sophisticated sorter extant. In addition, the Core will manage all flow cytometric data collected by researchers and clinical trials, and assist in the analysis and presentation of flow cytometric experiments.
The mission of the Human Immunology Section is to understand the induction, maintenance, and reconstitution of immunity in humans. We approach this from the point of view of T cell clonotype—their specificity and frequency. By studying HIV disease and vaccination against HIV, we aim to establish correlates of effective and protective immunity. By studying immune reconstitution, we aim to understand the mechanisms by which recovery from HIV disease can be enhanced. Together, these approaches address both prevention and effective treatment of HIV disease.
The mission of the Immunology Core Laboratory is to develop, validate, and perform assays of the immune response to HIV and other pathogens on clinical samples derived from recipients of candidate vaccines. The Immunology Core Laboratory seeks to perform the most sensitive and reliable assays as endpoints of Phase I and II clinical trials carried out through the VRC clinical trials program or other collaborators. In addition, the laboratory strives to constantly develop new assays and improve upon existing assays, that these improvements may allow us to better understand the nature of the immune responses generated by candidate vaccines.
The mission of the Immunology Laboratory is to investigate novel aspects of the cellular immune response to pathogens in support of the rational development of a vaccine against HIV. It is the goal of the Immunology Laboratory and its sections to rapidly advance the latest information on ways of manipulating the immune response to HIV into practical applications in clinical trials of prophylactic and therapeutic vaccines. In support of this effort, we emphasize a detailed analysis of the strength, breadth, plasticity, phenotype, and functional characteristics of the cellular immune response to HIV during natural infection, and how it does or does not differ from the immune response generated after vaccination.
The goal of the ImmunoTechnology Section is to elucidate the complex heterogeneity of the immune system. In particular, the major focus of the Laboratory is to define the functional roles of each uniquely identifiable leukocyte subset in the healthy immune system and to understand how perturbations in the balance of these subsets leads to disease. A fundamental strength of the Laboratory is the development and application of highly sophisticated technologies required for this research. The Laboratory participates not only in the dissemination of these technologies to other researchers, but in the application of these tools to clinical medicine and vaccine trials.
The mission of Laboratory Animal Medicine is to provide research support, information, and services and to assist in the design and conduct of critical research. We ensure the highest quality animal models are available through programs of animal husbandry as well as disease prevention, diagnosis, control, and treatment. These services are provided in the context of ensuring the well-being of our animal subjects and complying with Federal laws, regulations, and standards as well as industry guidelines.
The Nonhuman Primate Immunogenicity Core (NIC) was established to support the research efforts of investigators at the Vaccine Research Center (VRC). The responsibilities of the NIC include consulting on the design and implementation of nonhuman primate studies, coordinating sample collections with the Laboratory of Animal Medicine, writing and defending animal study protocols, developing and validating standard operating procedures, performing assays according to good laboratory practice guidelines, collating, analyzing, and coordinating data, and preparing oral and written presentations of studies.
The Structural Bioinformatics Core Section (SBIS) utilizes the tools of computational biology and structural bioinformatics to assist in the rational design of an effective HIV-1 vaccine. Currently, the SBIS is addressing multiple vaccine-design problems: (1) Design of immunogens based on atomic-level information, such as structure-based silencing of immunodominant but non-neutralizing epitopes or structure-based maximizing of the likelihood of neutralizing antibody re-elicitation by mimicking the antibody maturation process; (2) Use of bioinformatics tools to understand the manner by which broadly neutralizing antibodies effectively neutralize HIV and the elicitation barriers such antibodies must overcome; and (3) Design of epitope-specific probes to identify and to analyze antibodies in complex sera from HIV-infected individuals and vaccinees. The SBIS closely interacts with other VRC sections including the Structural Biology Section, which provides much of the structural data on which SBIS designs are based, and the Viral Pathogenesis and BSL-3 laboratories, which play key roles in understanding the immune response to natural infection by HIV and in testing SBIS-designed immunogens. Computational techniques used by the SBIS include physical simulation, structure prediction and modeling, protein (re-)design, and sequence analysis.
The Structural Biology Section of the Vaccine Research Center applies the tools of atomic-level analysis – primarily X-ray crystallography – to the development of an effective HIV-1 vaccine. Investigations fall into three areas: the mechanisms by which viruses evade the humoral immune response; the manner by which the humoral immune system is nonetheless able to overcome such mechanisms with potent broadly neutralizing antibodies; and the immunogens – how structure-based manipulation can lead to the elicitation of a broadly neutralizing immune response. Collaborations with other sections/cores of the VRC are likely to be integral to deciphering and exploiting the virological, immunological, and biological implications of the atomic structures. Intramural interactions with other structural biology sections have aided in establishing the infrastructure and in developing the methodology necessary to attack these technically challenging structural projects.
The Vaccine Production Program (VPP) at the VRC is dedicated to advancing candidate products from the laboratory to the clinic. The VPP develops manufacturing processes and release tests that provide material for Phase I/II clinical trials, with particular emphasis on techniques suitable for eventual large-scale manufacture of vaccines. Facilities at the VRC as well as contract agreements are used for production, and a cGMP pilot plant is currently under construction in Frederick, MD. In addition to production, the VPP manages the timelines of vaccine projects selected for clinical trial evaluation, prepares regulatory submissions, and develops appropriate preclinical testing for all vaccine products.
The Viral Pathogenesis Laboratory studies viral immunity and is developing animal models of viral immunopathogenesis. The Laboratory's work on the biology of respiratory syncytial virus and mechanisms of immunity serves as one such model applicable to the study of HIV immunopathogenesis. The projects aim to define the mechanisms by which: 1) RSV-induced immune responses interact with allergic inflammation to cause airway hyperresponsiveness, 2) the RSV G glycoprotein induces IL-5 and eosinophilia, 3) IL-4 and other cytokine influence the mechanism of CD8+ CTL-mediated target cell killing, and 4) how RhoA activation affects virus morphogenesis, membrane fusion, and early immune responses. The murine model of RSV also serves as a tool for evaluating new HIV vaccine concepts.
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Last Updated April 14, 2010