text:
Dr. Agah is a Fellow in Interventional Cardiology at the Cleveland Clinic Foundation, Cleveland, OH.
The last decade has seen tremendous growth in basic research attempting to target disease at the deoxyribonucleic acid (DNA) level. At present, there are more than 500 trials in gene therapy. Approximately 50 of these are cardiovascular studies, 1 which target treatment for coronary artery disease, peripheral vascular disease, and restenosis. Most current gene therapies require invasive measures to deliver the treatment vector locally. Hence, once these investigational tools become a clinical reality, the invasive/interventional cardiologist would play a central role in the delivery of these treatments.
However, the early promise offered by gene therapy has given way to cautious optimism as the field has matured. The past year best represents a watershed in this process as the Food and Drug Administration suspended all ongoing gene therapy trials involving adenovirus, following the death of an 18-year-old subject in a phase I trial targeting therapy for ornithine transcarbamylase deficiency. This suspension included several trials in cardiovascular medicine targeting treatment for coronary and peripheral vascular diseases using angiogenic factors. Following extensive review of present protocols by panels of experts, these trials have recently resumed with stricter guidelines. The purpose of this review is to assess the present status of cardiovascular gene therapy, following a short review of the fundamentals of gene-based therapy.
The basis of gene therapy lies in altering the pathophysiology of the disease process by introduction of DNA for a specific gene into cells. 2 There are several prerequisites for this process: 1) understanding the molecular mechanisms involved in the disease process and areas for potential targeted therapy; 2) isolation of the gene of interest for targeted therapy (cloning of the gene); 3) availability of vectors to introduce the gene of interest into the targeted cells; and 4) expression of the therapeutic gene in the host cells in a manner to produce the desired effect with minimal toxicity to the organism.
The success of the latter two points relies in development of "ideal" gene therapy vectors. Although there has been significant progress in the field in the last decade, the development of such vectors remains the "Achilles' heel" of the field of gene therapy. 3 These vectors fall into two broad categories: the viral and nonviral vectors. Although the nonviral vectors can be generated in large amounts and are generally safer, they remain inefficient in the transfer of genetic material.
At present, most gene therapy trials rely on viral vectors. 4 The viral vectors are generated on the premise of cloning the gene of interest in the virus and using the natural ability of the virus in infecting host cells to deliver the (therapeutic) gene into the cells. To abrogate the cytopathic effect, the virus is made replication-deficient by removing the genetic component necessary for viral replication (figure 1). These altered viruses are replication-incompetent, making them safe for human use. The recombinant viruses can be grown to high titer for infection of a large number of cells. Once grown to high titer in culture and purified, they can be introduced in vivo to infect the targeted cells and express the gene of interest.
Restenosis appears to be an "ideal disease" for gene-targeted therapy in cardiovascular medicine. 5 The tissue injury response to angioplasty is one of smooth muscle cell migration-proliferation and constrictive remodeling. While both processes take place with balloon angioplasty, only the former has a significant role in in-stent restenosis. With wide application of stents and late treatment of balloon angioplasty "failures" with placement of stents, the restenotic process in percutaneous coronary intervention has become mainly one of neointimal hyperplasia-smooth muscle proliferation and migration. With expanded knowledge of factors involved in cell cycle division and ligands that can activate these factors (cytokines, growth factors, transcription factors) strategies for inhibiting cell division by blocking these factors have emerged (Table 1). The successful approaches have included delivery of anti-sense oligonucleotides, naked DNA, and recombinant adenovirus introducing the recombinant gene able to inhibit cell division. When used in vivo, these vectors have been able to prevent restenosis in multiple animal models, including the rat carotid artery, the rabbit iliac artery, and the porcine femoral and coronary arteries. 6-8 Despite their success in inhibiting restenosis in animal models, early experience in human studies has been disappointing. The reasons primarily appear to be inefficient local delivery of vectors via conventional interventional techniques and low transfection/infection efficiency of the vectors. This early failure, along with emerging alternative treatment for restenosis (including brachytherapy and coated stents), has dampened the initial flood of gene therapy trials for restenosis, with only one ongoing trial still in progress in the United States.
In contrast to declining mortality from coronary disease, deaths from heart failure have doubled in the last 2 decades. As most of these patients are elderly and are not candidates for cardiac transplantation, medical treatment remains the only option available to these patients. As such, these patients are ideal candidates for percutaneous gene therapy approaches.
There are several obstacles that need to be addressed in any approach for gene-based therapies in heart failure, however: 1) widespread, if not uniform, transduction of the cardiac cells by the vectors and the delivery technique; 2) long-term expression/effect of the delivered gene and/or ability for readministration; and 3) targeted therapy for the underlying pathophysiologic mechanism of heart failure, i.e., systolic versus diastolic dysfunction. We shall address the progress in each of these areas below. 9
The formidable task of delivering the gene therapy vector to the billions of cardiac cells is potentially remedied by the rich vascular supply to this organ via the coronary arteries. Earlier reports that coronary injection of adenoviral vectors can transduce 10% to 30% of cardiac myocytes have given way to modified approaches where now it is possible to transduce greater than 50% of all cardiac cells. These techniques have included transient cross-clamping of the aorta and pulmonary artery after injection of the viral vector in the left ventricular chamber. A less robust but easier approach involves cross-clamping only the aorta during the infusion. Although the percutaneous approach for such techniques is not yet established in humans, it may be clinically tolerated in the same way that the aortic occlusion during aortic valvuloplasty is well tolerated by patients for a short duration of 10 to 20 seconds.
In contrast to gene therapy approaches in restenosis, in which transient expression of the therapeutic gene may be sufficient for the treatment effect, most protocols for therapies in heart failure require long-term expression of the therapeutic gene. Although recombinant adenovirus has been a natural choice for restenosis studies, the early generation adenoviral vectors are inadequate for treatments of heart failure due to the transient nature of gene expression. Furthermore, since adenoviral gene expression is eliminated primarily via an immune response to adenoviral genes, such global cardiac immune response has the potential for myocarditis. As such, gene therapy protocols in heart failure had to await the development of a vector with minimal induction of host immune response upon delivery, ability for long-term expression of the transgene, and sustained and efficient transduction of the cardiac myocytes. These vectors have come of age in the last several years. One such vector has been the third-generation adenoviral vector, from which most of the viral "backbone" has been eliminated as well, and hence the accompanying immune response. Such modification has led to long-term expression of the transgene.
Another vector with potential application for cardiac gene therapy is the adeno-associated virus; this vector has the ability to transduce cardiac myocytes with similar efficiency as adenovirus, but does not elicit an immune response that eliminates the transduced cells. As such, they can have long-term expression in cardiac tissue after single administration. However, they are difficult to grow to high titers in tissue culture.
The study of cardiac myocytes in failing heart has revealed multiple molecular abnormalities leading to depressed contractile function of these cells. Broadly, two signaling pathways involved in contractility have been targeted so far. One pathway involves intracellular calcium regulation. There is intracellular release of calcium in the myocytes with electrical excitation leading to myofibril contraction. During myofibril relaxation, calcium is extruded extracellularly mainly by the sarcoplasmic reticulum calcium adenosinetriphosphatase (ATPase) pump (SERC2a). In turn, the activity of SERC2a pump is regulated by phospholamban. Studies of single myocytes from failing hearts have revealed elevated end-diastolic calcium levels in these cells associated with reduced systolic force, elevated diastolic force, and abnormal relaxation. These abnormalities in calcium regulation are associated with decreased ratio of SERC2a to phospholamban. Several in-vitro and in-vivo studies have shown that restoring the effective SERC2a/phospholamban ratio can restore myocyte contractility and systolic function in animal models of heart failure. 10 These studies have paved the way for targeting SERC2a and phospholamban to failing human heart cells.
Another signaling pathway for targeted therapy, with a better clinical correlate for therapeutic efficacy, is the beta (ß)-adrenergic signaling. It is well known that in heart failure there is down regulation of the myocardial ß-adrenergic receptor (ß-AR) along with upregulation of an inhibitor of receptor signaling ß-AR kinase-1 (ßarK-1). One of the clinical benefits of administering oral ß-blockers in heart failure patients is thought to be secondary to restoring this signaling mechanism. Several studies have shown that adenoviral delivery of ßarK-1 can rescue the heart failure phenotypes in various animal models. 11
The concept of apoptosis as the final common molecular pathway in the diverse spectrum of heart failure has sparked interest in local delivery of various anti-apoptotic factors to prevent progression of cardiac cell death. However, data demonstrating the benefit of such "rescue" in relevant animal models is not available at this time.
Treatment of ischemia by increasing the number of small vessels in the ischemic tissue--angiogenesis--has been the focal point of research for patients not candidates for traditional means of revascularization. No area in cardiovascular gene therapy has generated as much interest and public enthusiasm as angiogenesis. This is particularly remarkable considering the limited amount of data available to demonstrate a clear clinical benefit of such an approach. 12 Because of the absence of published placebo-controlled, randomized clinical trials (although several are in progress), we shall limit this review to studies of angiogenesis in animal models. As a whole, most studies have concentrated on two families of angiogenic factors: vascular endothelial growth factor (VEGF) and fibroblast growth factors (FGF). These factors have been delivered as recombinant protein, plasmid DNA, and adenovirus encoding the cDNA of the growth factor. The routes of administration have also varied, but typically can be categorized as direct intramyocardial injection versus intracoronary injection.
In a study by Rosengart et al 13 using an ischemic porcine model, these authors were able to show that 4 weeks after injection of adenovirus (Ad.) carrying the VEGF gene, Ad.VEGF-121, both regional function (echocardiography) and perfusion (radionuclide imaging) were improved in the Ad.VEGF-121-treated animals when compared with control. Similar results that related improvement in regional blood flow (using microspheres) were published by Isner et al, with injection of plasmid DNA (ph.VEGF-165). 14 Hammond et al, 15 using the same porcine model, delivered Ad.FGF-5 to the ischemic area using an intracoronary approach. Two weeks after gene transfer, there was improvement in stress-induced ischemia (assessed by echo) in the Ad.FGF-5-treated animals compared with controls. The results of these animal studies are supported by uncontrolled observational reports where injection of angiogenic factors in the ischemic myocardium results in subjective improvements in patients' symptoms. Currently there are multiple ongoing phase 2 and phase 3 clinical trials evaluating the efficacy of both FGF and VEGF in improving ischemia in patients not candidates for traditional revascularization. The results of these trials are awaited with great anticipation, as they may establish the first gene-based therapy in clinical cardiology.
Vein graft failure after coronary artery bypass graft surgery and peripheral bypass surgery may be the ideal clinical setting for gene therapy applications. The excision of the graft from the host allows the tissue to be manipulated "ex vivo" before it is re-implanted in the subject. 16 As such, uniform and controlled transgene transduction can be made before re-implantation. As we gain more knowledge in the pathophysiology of graft failure and its distinct nature from atherosclerosis, we will be better able to target therapy to this clinical problem. Preliminary studies in animal models targeting antiproliferative and antimatrix agents using adenoviral and retroviral vectors has met with initial success in limiting graft restenosis and subsequent failure. Noteworthy in these approaches is the result of the PREVENT study. 17 This was a single-center, phase 1 trial to assess the safety of using an anti-sense oligonucleotide decoy against the cell cycle regulator gene, E2F, to block neointima growth and prevent graft failure of peripheral arterial bypass grafts in high-risk patients. Although the study was not designed to assess clinical outcome, at 1 year patients in the treatment group had a 29% rate of graft failure compared with 69% in the control group. These encouraging early results await validation by large-scale randomized trials.
No direct gene therapy approach to atherosclerosis exists today due to the multifactorial, multistage, and insidious nature of this disease. However, directed therapies against hypercholesterolemia, a major risk factor for development of atherosclerosis, are in progress with encouraging early results in animal models 18,19 and a small phase 1 trial in humans. 20 Similar approaches exist for the treatment of hypertension with early success in animal models. 21 However, progress in both these areas is slow due to the existence of effective medical therapy for both conditions.
With experience from the past decade, the field of gene therapy is making steady progress toward becoming a clinical reality. With active research and ongoing trials in heart failure, restenosis, and angiogenesis, the next decade may see the first successful application of this novel therapy in a broad spectrum of patients.


text:
On Saturday night in Perth Axl Rose reportedly injured a fan during the opening night of Guns N' Roses' Australian tour, and now the fan plans to take the matter to court.
Triple M reports that a 39-year old fan named Darren Wright, was left bleeding and had bits of tooth missing when Axl chucked his mic into the crowd and hit the dude square in the mouth. And now he wants Rose to pay his dental bills. The tour promoter reportedly apologized and offered an autographed microphone from Rose instead.
Apparently Wright is not interested in Axl's kind gesture and will, instead, take the matter to court.
Earlier this week Van Halen singer David Lee Roth claimed that he and his band will embark on a massive tour of the UK and Europe this year but now Van Halen's manager Irv Azoff says not so fast, Dave. He tells Billboard: "All the announced dates, which include the date in Australia, the dates in Japan and a date in Wisconsin, are confirmed and on sale, and those are real. I manage the Van Halens and I know nothing about any European tour." The band's been sitting dormant since August when Eddie Van Halen suffered a case of diverculititis which forced him into surgery, and forced VH to cancel the remainder of their US tour.

subset: commoncrawl


text:
March 17th London Premiere for Robert Pattinson's "Remember Me" ?
Both Heatworld and ASOS websites are running competitions to give away tickets to the Premiere!
From Heatworld
We have FIVE pairs of tickets to give away to the premiere of Robert Pattinson's new movie Remember Me, taking place at the Odeon Leicester Square on Wednesday 17 March.
Remember Me will be released in cinemas across the UK & Ireland on April 2, 2010
Go Here to enter
From ASOS
In his first major role outside of the Twilight saga, Robert Pattinson will join his fellow co-stars in London on Wednesday 17th March for the UK premiere of Remember Me - and we've got a super-exclusive pair of tickets to giveaway! The winner and a friend will join the stars and special guests on the red carpet, before seeing the first UK screening of the film.
Go Here to enter
via Source
48 comments:
- CullenLover07 said...
Oh yay! More premiere pics. To all the UK ladies, we will need a English version of Robstock! Videos and pictures, please.
- March 8, 2010 at 9:17 AM
- rpattzgirl said...
I guess this squellches the rumors that he'll be in NY for the Runaways premier on 3/17!!!
Yes photos & vids please!!! - March 8, 2010 at 9:27 AM
- Fae007Exec.Prod. said...
OMG! St. Patrick's!!! :DDDDD
- March 8, 2010 at 9:33 AM
- wensdazzled said...
yay--we may get TuxRob yet!!
- March 8, 2010 at 9:45 AM
- robxD said...
Oh ja, the full Rob- Premiere-Program, arround the world in every country the hole year.;)
- March 8, 2010 at 9:58 AM
- Rosy said...
ok, so i just came across this link and saw the craziest site about Rob....please tell me somebody here has already seen this and knows it's fake. I mean, I know it MUST be fake, but still...kinda want to confirm that! lol!
http://www.robertpattinson11.com/ - March 8, 2010 at 10:21 AM
- Chocolate Martini Gal said...
I hope one of our UK/Euro ladies is a winner!!
- March 8, 2010 at 10:22 AM
- CullenLover07 said...
OT - But did anyone see the Jimmy Kimmel skit from last night, The Handsome Mens Club. That sh*t is funny. LOL funny.
- March 8, 2010 at 10:27 AM
- Jeanette said...
Rosy just checked out the link it has to be fake sounds like total rubish
- March 8, 2010 at 10:28 AM
- Shanea said...
Rosy: Total rubbish... :)
- March 8, 2010 at 10:33 AM
- Rosy said...
lol! i figured as much...i wonder if there are people who actually pay this fraud money for the crap he/she's selling?!??! how sad..
- March 8, 2010 at 10:35 AM
- Rosy said...
@CL - i just saw it a few minutes ago and it was absolutely genius!
- March 8, 2010 at 10:36 AM
- Twi_Chic said...
- This comment has been removed by the author.
- March 8, 2010 at 10:37 AM
- Cindygal said...
...i cant waif for pics...YAY
- March 8, 2010 at 10:40 AM
- sissidelyon said...
- This comment has been removed by the author.
- March 8, 2010 at 10:41 AM
- Twi_Chic said...
I am in Ireland, and just had the spontaneous thought of possibly coming over for this, as its Paddy's Day here. And I am due to be in London that following Sat anyow - why not come over earlier and make a little holiday out of it?!! Am I mad? LOL... anyone going? Although I lived in London, I had never been down to Leicester Sq for a premiere - is it worth going down? How early would you need to be there etc?
- March 8, 2010 at 10:44 AM
- janna said...
the question mark in the title means this is as yet unconfirmed, yes?
- March 8, 2010 at 10:45 AM
- CullenLover07 said...
@Rosy - It was brilliant.
I just read that Summit confirmed the March 17th premiere date. - March 8, 2010 at 10:47 AM
- Gwen Cooper 426 said...
Exactly what CL said! Oh, and I'm terribly jealous. That too. ;)
- March 8, 2010 at 10:49 AM
- Fae007Exec.Prod. said...
@Rosy GIBBERISH!!! yeah he's not born May 13th, that's why his parents travelled all the way to Vancouver to be with him on that day! (rolls eyes!)
- March 8, 2010 at 10:50 AM
- Fae007Exec.Prod. said...
- This comment has been removed by the author.
- March 8, 2010 at 10:50 AM
- Christine said...
I hope I can see it opening day this Friday! I'm trying with my everything to see it that day! haha.
- March 8, 2010 at 10:58 AM
- Maryann said...
Figures..I return to Norway on Monday March 15th...2 days before this..TWO DAYS!!! FML!
- March 8, 2010 at 11:01 AM
- Rosy said...
so i take it Rob has been keeping a super low profile since returning to London...aside from being spotted with his friends that first night back at home, he hasn't been spotted again.....where are all those twitterers who saw him out when Kristen was there? they need to get out there more! lol
- March 8, 2010 at 11:04 AM
- sissidelyon said...
@CullenLover07. I just watch Jimmy Kimmel on Youtube.. It was so funny. I'm at work in front of my computer, laughing alone... LOL...
- March 8, 2010 at 11:15 AM
- Little Red said...
Done and done! Someone has to win right?! Gotta be in it to win it as they say...
- March 8, 2010 at 11:25 AM
- Robine said...
Wow that's great! anyone knows whether he'll promote it in France?
- March 8, 2010 at 11:39 AM
- WhyIstheRumAlwaysGone said...
Oh no - I've checked and of course it's for Brit residents only. So I can't even try. Anyway it will probably be complete madness. Too bad... London's so close to Paris... ah well it wasn't meant to be I guess... unless they suddenly decide on a Paris premiere. Not very likely. :((
- March 8, 2010 at 12:15 PM
- angie-k said...
ROBSTOCK UK Edition!!!
If you get the chance to go to the premiere go EARLY!!!! We were there at 6 am and there were 15 people who were ahead of us...
Worth every minute spent waiting!
;) - March 8, 2010 at 12:20 PM
- Audrey said...
Noooooo..I thought that Rob could go in NY to TR´s premiere!!!
But, as well, if it´s the Premiere in Longon, very good for Rob. - March 8, 2010 at 12:29 PM
- janna said...
this is still unconfirmed Audrey, the only summit 'confirmation' I saw was from a remember me fans twitter, that was retweeted as if it were official. the other websites are using these contests as confirmation and most are still using a question mark like this blog
- March 8, 2010 at 12:34 PM
- Audrey said...
- This comment has been removed by the author.
- March 8, 2010 at 12:38 PM
- Audrey said...
Thanks Janna!!
I hope very soon will know more about the London´s Premiere.
This week, Kristen has got a lot a interviews, and a lot of people say that Jay Leno is able to be confessed Kristen about Rob.
Her agenda:
03/10: Kristen on Jay Leno
03/11: Kristen at "The Runaways" LA Premiere
03/14: kristen and Dakota at Premiere The Runaways in Toronto
03/15: kristen and Dakota at Premiere The Runaways in Vancouver
03/16: Kristen in Regis and Kelly´s program
03/17: Kristen at "The Runaways" NY Premiere - March 8, 2010 at 12:44 PM
- Audrey said...
- This comment has been removed by the author.
- March 8, 2010 at 12:48 PM
- Audrey said...
Look this pic, (kris and Talor in the Vanity Fair´s after party)
Sure that tomorrow, the magazines´s tittles, What will Rob think about it??
All we know that the medias almost always see wrong things.
http://www.eclipsemovie.org - March 8, 2010 at 12:55 PM
- AP said...
Fun for the UK fans - and will he 'tie' it this time? Not sure, he wants to keep it cas, in keeping with Tyler and RM...
On Leno: is Kristen going to say she likes Rob? Never would have guessed and I have to miss that show...oh, woe... ;) - March 8, 2010 at 1:17 PM
- sissidelyon said...
- This comment has been removed by the author.
- March 8, 2010 at 1:32 PM
- sissidelyon said...
@Audrey.. Don't bother with what people think about these pictures. Kris and Taylor are very close friends and just so cute together... Brother/sister like... My own opinion! Kristen is so natural when with Taylor, it's nice to see her not having to be careful about what she does or says... It's like taylor is saying, "Stop that!....you were amazing out there".
- March 8, 2010 at 1:42 PM
- Audrey said...
@ sissidelyon
I know that you´re right, much of us knows that they are very closed, they love each other as brother and sister but much of people like put zizania.
Kristen with Taylor is very natural, she hasn´t got concern and for this she could be herself. With Rob it´s different because the medias spoils all. I hope, one day, they can live their love quietly without thinking on the medias as they given - March 8, 2010 at 1:47 PM
- sissidelyon said...
Just keep hoping Audrey... Now, back to Rob for our own security... LOL... Not really the place to discuss other matters... LOL...
- March 8, 2010 at 1:50 PM
- Carole UK said...
Well, I'd got it into my head that RM was going to showing in the UK pretty soon, so I'm really disappointed that I've got to wait even longer .....
Finding it increasingly difficult to avoid the reviews but I desperately don't want to know what the "shock end" storyline is - so, ladies, I'm begging, please please please give spoiler warnings if you want to discuss that ending!
Just read Water for Elephants in 3 evenings - a wonderful story and I can so see Rob doing a really great job of the Jacob Pankowski role ... - March 8, 2010 at 2:19 PM
- janna said...
I still cannot buy tickets yet in my city, and it opens friday
- March 8, 2010 at 2:32 PM
- Catwoman said...
Yay!!! Sooo excited!
But, aaagh!!! Have meetings in Edinburgh for the whole of that day.
Will have to think of some work- related excuse to be in London, failing that I shall just have to leave my job...
(I'll be losing said job anyway soon since I spend so much time here - ah well...) - March 8, 2010 at 2:40 PM
- solas said...
Ahh, I was disappointed to see that Rob would not make Kristen's premere, but the 17 is her Ny premiere; she has an LA premiere on the 11th; perhaps Rob can fly out for that if his schedule and strength allow for that. I wonder if she will have a London Premiere as well. That would surely be easier for them both, as London seems to treat them better.
- March 8, 2010 at 3:43 PM
- lallieb said...
@Audrey, this site is devoted to Robert. Kristen typically only gets mentioned here when there is a photo of her posted with Robert, and even then (always!) the thread becomes very combative. There are a wide range of thoughts/opinions about their relationship, but experience has shown that it is best to keep those to oneself. Until they actually "come out", if ever they do, the conventional wisdom is no one knows for SURE.
Sissy was not kidding about "security". It's best to stick to subject of Rob...alone, especially when she's not anywhere in the post. Not preaching, I'm just saying...things get ugly. - March 8, 2010 at 4:53 PM
- shirleegirl said...
First of all - the person writes like a 12 year old girl - 2nd, looks like one of those scams where you click on the link and they get all your personal information. Plus, I think his parents know when his birthday is!
- March 8, 2010 at 8:03 PM
- Delle1 said...
If that article is true then why did his parents celebrate with him and Kristen in Italy last yr....
I thought The Runaways premiere is on the 11th?...... - March 8, 2010 at 11:58 PM
- Audrey said...
Firts able, I apologized to talk yesterday about Kristen on the similar date of Premiere of THE RUNAWAYS and REMEBER ME.
Now, Summit confirmed that Rob will attend the Premiere in London. - March 9, 2010 at 4:09 AM


text:
Comments about 'Farrell, Walken, Rockwell, Harrelson have a lark in 'Psychopaths''
- Oldest first
- Newest first
- Most recommended
Login to comment
DeseretNews.com encourages a civil dialogue among its readers. We welcome your thoughtful comments.
— About comments
What You May Have Missed
Most Popular
Across Site
In Family Media
- Why one Mormon man left Hollywood to be a...
- Wright Words: Christmas Jars tradition...
- Linda & Richard Eyre: Ann and Mitt Romney...
- Julie Andrews missed NBC's live 'Sound of Music'
- Toddler basketball star, 'Trick-Shot-Titus,'...
- Sundance to premiere 117 independent feature...
- Ballet West's 'Nutcracker' a splendid success
- The Bandito gets into the Christmas spirit
Most Commented
Across Site
In Family Media
- 'Deseret News Sunday Edition' looks at... 10
- 'Sound of Music' hit a high note for... 9
- Linda & Richard Eyre: Ann and Mitt... 7
- Why one Mormon man left Hollywood to be... 7
- Joseph Cramer, M.D.: What if negative... 6
- Toddler basketball star,... 5
- Wright Words: Christmas Jars tradition... 2
- Study: Erratic TV violence ratings fail... 1


text:
The Independent
By Paul Vallely
The children of the Grace Revival School do not have far to go when they need the lavatory.They get up from their ramshackle desks and move just outside their corrugated ironclassroom to the vast dungheap that stands beside the building.There are no latrines for the 74,000 people who live in their section of Kibera, the biggestslum in Africa, which lies either side of the main railway line between Nairobi and Mombasa inthe Kenyan highlands.People there use what, with dark humour, are called "flying toilets". They defecate in a plasticbag and then throw it into the street or on to one of the vast dungheaps. Some just visit theheaps and relieve themselves directly. The heap next to Grace school is about 20 feet highand the size of a quarter of a football pitch.The stench is unimaginable. When it rains, a noxious black liquid runs off the heap, andthrough the school, over the dirt floor of the classrooms. It seeps into the drinking watersupply pipes, which run beneath the dump.There is more to this story than a piece of prurient poverty pornography. It has a point, whichis the one made more genteelly by the UN's annual Human Development Report, publishedtomorrow. For Kibera is but one stark example of what is perhaps the greatest developmentalchallenge facing humanity. More than one billion people live without clean water. Some 2.6billion - half of the developing world's population - lack access to sanitation. The two issuesare inextricably linked, for without proper sanitation pollution of drinking water is almostinevitable.At the start of the 21st century, 5,000 children die every day for want of clean water. That iswhy, in the sprawling slum of Kibera, where typhoid and dysentery are rampant, KevinWatkins, the chief researcher of the UN report, found that child death rates run eight timeshigher even than in the rest of Nairobi. We know from our own history that providingsanitation and clean water is the biggest single thing that can be done for the poor. Dysentery,typhoid and cholera killed as many children in Manchester and London in early Victorian timesas they do in Africa today. The increasing wealth from industrialisa-tion boosted income, butchild mortality barely changed - until the introduction of sewers. It was the same in New York,Birmingham and Paris.Water and sanitation are among the most powerful preventive medicines available to reduceinfectious disease. The presence of a flush lavatory in a house, the UN report says, reducesthe risk of infant death by more than 30 per cent. Sewers save more lives than antibiotics.Astonishingly, then - despite one of the Millennium Development Goals being to halve thenumber of people without water and sanitation - the amount of aid to this sector has,according to the Commission for Africa, fallen by 25 per cent over the past decade.The problem is twofold. The first is that such basics are unfashionable among Western donorgovernments. The second is that many African and Asian governments do not priori-tise thearea; in Ethiopia the military budget is 10 times the water and sanitation budget; Pakistanspends 47 times more on guns than on sewers and clean water. Why? Because water andsanitation are problems which disproportionately affect the poorest, women and children inparticular, - a class which has no political leverage with urban Third World elites.Water is about power. The most striking political example of which, the report shows, is thatIsraeli settlers take six times the water from the West Bank as local Palestinians. But there arecountless eco-nomic examples. In Ghana the poorest, who use standpipes provided by privatecompanies, pay treble what the better-off pay for water piped to their homes. In Kibera theypay five times more. People living in many of the world's most squalid slums pay more perlitre for water than people in New York and London. The perverse rule operating in watermarkets is that the poorer you are, the less you get and the more you pay.To set aside the financial resources to fulfil the Millennium Development Goal to halve thenumber of people without sustainable access to safe water would cost about $10bn (£5.3bn)annually over the next decade. It requires sustained efforts and specific strategies. Generaleconomic development is not enough. It can be seen by contrasting India - which has abooming economy but no proper targeting on clean water and sewers - with Bangladesh -which has less growth but effective water strategies. India's people are becoming wealthierbut not healthier. Some 700 million people there lack adequate sanitation - and in cities suchas Delhi and Mumbai the water systems are collapsing, with rivers being transformed into fetidsewers. As a result infant mortality is down by just 22 per cent since 1990, compared with adrop of 40 per cent in much poorer Bangladesh.The UN report is full of examples of strategies that have worked, and those that have not. Itcites success stories in Thailand, Sri Lanka and Vietnam and comparative good news in SouthAfrica, where water was once a symbol of apartheid division, but a system of entitlement hasbeen introduced. It should be extended across the world, the report says, with allgovernments legislating for water as a human right, with a basic minimum of 20 litres perperson per day - less than half of what we in Britain each flush daily down the lavatory.To do that, the report says, would increase aid spending by about $4bn a year. That is lessthan Europe spends on bottled mineral water.Liquid assetsThe average Briton flushes 50 litres of water down the lavatory each day - ten times whatmany Africans have for drinking and washing.One in six of the world's population lacks clean water and one in three lacks proper sanitation- that's pit latrines, not sewage systems.The average European uses 200 litres of water a day compared with less than 20 per personper day in Africa. (Americans use 400 litres.)1.8 million children under five die each year from diarrhoea caused by contaminated water.Every $1 spent on sewage saves $8 in lost productivity.The $10bn the Millennium Development Goal needs to halve the number of people withoutclean water equals five days of global military spending.
Return to the list <<<<<


text:
To share this article: Enter the email address you want to send this article to in the field and click "Send"
By PAULNEWBERRY The Associated Press
ATLANTA - The clutch quarterback. The genius coach. The big-play defense.
The San Francisco 49ers are ready to start a new dynasty with a familiar formula.
Next stop, the Big Easy.
Colin Kaepernick and Frank Gore led San Francisco to a record comeback in the NFC championship game Sunday, overcoming an early 17-0 deficit to beat the Atlanta Falcons 28-24 and send the 49ers to their first Super Bowl since 1995.
Gore scored a pair of touchdowns, including the winner with 8:23 remaining for San Francisco's first lead of the day, and the 49ers defense made it stand up. A fourth-down stop at the 10-yard line denied Atlanta another stirring comeback after blowing a big lead.
"Everybody does a little," 49ers coach Jim Harbaugh said, "and it adds up to be a lot."
San Francisco (13-4-1) moves on to face Baltimore at New Orleans in two weeks, looking to join Pittsburgh as the only franchises with six Super Bowl titles. It will be a brother-vs.-brother matchup, too, since John Harbaugh coaches the Ravens.
Joe Montana led the 49ers to four Super Bowl wins, and Steve Young took them to No. 5. It's up to Kaepernick and Co. to get No. 6.
"He just competes like a maniac all the time," said Harbaugh, whose much-debated decision to bench Alex Smith at midseason now looks like the best move of the year. "It's always the same when I'm looking in through the facemask."
The second-year quarterback, who runs like a track star, didn't get a chance to show off his touchdown celebration - flexing his right arm and kissing his bicep, a move that quickly became a social media sensation known as Kaepernicking.
But he shredded the Falcons through the air by completing 16 of 21 for 233 yards, including a 4-yard touchdown to Vernon Davis, and had them so worried about his running ability out of the spread option that Gore and LaMichael James had plenty of room.
Gore scored a pair of touchdowns, including the game winner with 8:23 remaining for San Francisco's first lead of the day. Davis scored the first TD for the 49ers on a 15-yard run.
"I take my hat off to Atlanta. They played hard. They've got a great team," Gore said. "But we fought, man. We fought and we deserved it."
The 49ers pulled off the biggest comeback victory in an NFC championship game, according to STATS. The previous NFC record was 13 points - Atlanta's victory over Minnesota in the 1999 title game, which sent the Falcons to what remains the only Super Bowl in franchise history.
In the AFC, the record is 18 points, when Indianapolis rallied past New England in 2007.
Harbaugh is hardly cool and collected like the 49ers' first Super Bowl-winning coach, Bill Walsh, but has pulled off a similar turnaround in San Francisco. The 49ers had eight straight years without a winning record before their new coach arrived from Stanford in 2011.
He immediately led San Francisco to the cusp of the Super Bowl, losing to the eventual champion New York Giants in overtime in last year's NFC title game, a bitter defeat at home set up by a fumbled return.
Fayobserver.com is using Facebook Comments. You must have a Facebook account and be logged in to Facebook to post your comment below. Your comment is subject to Facebook's Privacy Policy and Terms of Service on data usage. Your comment will appear on our site and on your Facebook page unless you uncheck the "Post to Facebook" box. We expect users to maintain a civil discourse. If you believe a comment is inappropriate, you may click the X in the upper right corner to send an abuse report to Facebook. To report an objectionable comment directly to Fayobserver.com, email firstname.lastname@example.com. Want to know more? Check out our FAQ.


text:
Bronx Shoes 83864 Lots Of Fun
SKU: #8130472Product Information
- Show off these lovely sandals for a day in the sun that's lots of fun!
- Smooth leather upper.
- Open-toe sandal design.
- Soft man-made lining and insole create a lightly padded footbed.
- Jute-wrapped platform and wedge.
- Adjustable buckle closure at ankle strap.
- Lugged man-made sole.
- Imported.
- Measurements:
- Heel Height: 4 in
- Weight: 10 oz
- Platform Height: 1 1⁄2 in
- Product measurements were taken using size 38 (US Women's 8), width M. Please note that measurements may vary by size.


text:
featured in Foil Invitations
featured in Party Invitations
featured in Corporate Holiday
featured in Birth Announcements
featured in Kid's Christmas
featured in Grad Announcements
featured in Holiday Invitations
featured in Personalized Stationery
We make finding the perfect photo engagement announcement or invitation a snap with our wide variety of photo items. Whether you want something quirky and fun or more traditional and romantic, your favorite photo will still be front and center. What guest wouldn't enjoy a great keepsake of the happy couple? Or, be truly unique and use a photo of the location of your wedding or of an inside joke instead. The possibilities are endless with these picture perfect engagement announcements. Browse our selection and get your creativity flowing!
Oops! You've narrowed your search a little too much! Clear your search and try again.
One Moment Please
Back to Top


text:
Search Result
Search Tags: crime solvers
A 38-year-old Woodbridge woman says she was sexually assaulted inside her bedroom by an unknown man who covered the bottom half of his face with a towel.
Tags: Crime Solvers, Prince William County police, sex assault
ListenMan, woman sought in Md. identity theft case
Montgomery County police are asking for help identifying suspects in an identify theft case.
Tags: Montgomery County Police, Crime Solvers, identity theft
Police looking for suspect who assaulted girl in Upper Marlboro
Prince George's County police are still looking for clues after they say a man led a 7-year-old girl into the woods and sexually assaulted her Saturday.
Tags: Upper Marlboro, heatermore, reward, Crime Solvers, pgpd
ListenPr. William County Police seek help identifying sexual assault suspect (Photo)
The Prince William County Police Department is asking for the public's help after a sexual assault in Woodbridge.
Tags: assault, reward, Crime Solvers, suspect composite, Woodbridge


text:
Christopher Tarjan and Jordan Ahnquist are sharing the stage in Stoneham Theatre's Season 14 opener, Seminar. Seminar, written by Theresa Rebeck, the creator of the TV show Smash, tells the story of four young writers who hire a world-famous novelist (Tarjan) to teach a seminar. Seminar does not mark the first time Tarjan and Ahnquist have worked together, however.
"I first worked with Jordan at Milwaukee Repertory Company," Tarjan shared. "I was doing a show, and Jordan was in the intern program." Tarjan later spotted Ahnquist in the audience of the Chicago production of Shear Madness and thought he would be good for the role of the nerdy police officer. "Fast forward 5 years…I get the job to direct Shear Madness in Boston and Jordan is playing the gay hair salon owner, a more challenging role," Tarjan added. "He had grown miles as an actor and performer."
Ahnquist, who plays Tarjan's writing student in Seminar, says that working with Tarjan again is a gift. "The comfort level and trust is already established," Ahnquist explained, "so it's easier to jump in the deep end and put the work first." Tarjan agrees. "There is a shorthand and a trust we have developed over many, many nights on stage together that only helps our relationship in Seminar, and ultimately the entire production."
Audiences have only four more chances to see Tarjan and Ahnquist in the New England premiere of Seminar at Stoneham Theatre: Thursday, September 26, 2013 at 7:30pm; Friday, September 27, 2013 at 8:00pm; Saturday, September 28, 2013 at 8:00pm; and Sunday, September 29, 2013 at 2:00pm. For tickets, please call the Stoneham Theatre Box Office at 781-279-2200, or visit www.stonehamtheatre.org.


text:
I've been using this serum in the evening after cleansing and before moisturiser and it's done a fantastic job of slowly fading very old acne scarring and sunspots. It has really evened out my skin tone and it's nice and light so doesn't feel like a heavy night serum, good for summer.
Marisa, Australia
I'd highly recommend giving this one a go if you want to even out your complexion. As others have said, you only need a small amount so it does last quite a long time and it does smell very fresh. I've been using for three months and I'm about 3/4 of the way through the bottle. Already purchased a second bottle.
This product made my skin look fresh, I normally suffer with a lot of redness in my cheeks but this product made my skin colour even. Would definitely recomend to friends and family
Lisa, Uk
I had really bad hyper pigmentation and since I started using this product my life has changed, it feels really light in the skin and do wonders!
Beatriz, Chile
I love the light almost watery texture that absorbs super fast. My hyper pigmentation lightens with continuous use of this. This really works and i like the light scent that is not overpowering. This is also very gentle and natural.
Mei, Singapore
I received a sample of this and it is amazing!! Very soothing and moisturizing. Worked wonderfully with my oily skin.
Mariana, Brazil
I think I've found my holy grail! With my troublesome skin that's prone to hyperpigmentation, I've lost count of the number of serums I've tried. But no more - this one is staying in my beauty arsenal! After using this, many of my darker patches are fading, my redness had reduced, and my skin looks more even in tone. I have an oily t-zone and dry cheeks, yet this doesn't exacerbate either. It smells fresh and fruity, and trust me - a little goes a long way, so it's great value for money!
Deb, Australia
I already have used 3 bottles of this and my skin complex has improved alot over the last few months. This is one of the most amazing serums! I love this, it is not oily at all so suitable for oily skin as well, and does not make any troubles. very gentle with fresh smell too!
Yunju, Bournemouth
It really works! The dark spot on my face looks smaller than before.
Titty, US
Gives your skin an instant glow and smells wonderful too. I have noticed a more even skin tone with continued use
Natalie, Sydney, Australia
Love this serum, makes my skin look radiant and bright. Will definitely repurchase
Pamela, Dublin
This is my favourite Caudalie product! I have used for over a year now and my skin has improved radically. Dark spots have diminished and it feels smooth and firm. I really recommend this product.
Susan, Sweden
Caudalie products are fantastic, I use the whole range. The serum evened out my skin tone and has lightened some acne scarring on my face after about 2 weeks use. My skin looks considerably brighter.
Maria, Norway
Honestly since I've been using this product from Caudalie, I can forget about applying foundation on my face and let my natural skin glow. Really effective!
Cécile, London
I purchased this product looking for anti-ageing protection and energy. It passed the exam! I use it at night under regular night cream for dry skin.
Kasia, Gdansk
Does what it says on the tin! I'd have to agree with all the reviews on this product - it's fab! Skin looked clearer, younger and brighter...as if I get a good 12 hour sleep every night. A must have!
Karen Schmitz, Aberdeen
This serum is the BEST I have ever used. It's not only for the older skin types, I'm only in my 20's and have suffered with acne and all kinds of skin pigmentation problems, causing skin to always appear red in patches or darker.
Claire Horton, Gloucester
I love the vinoperfect range, its perfect for older skin, or skin types with my problems.
This serum completely evens out those pigmentation marks, and sort of acne scars or sun scars you have.
There's articles about this product all over the web, about how it helps these kind of problems, it's dearer than an average serum but it does a millon times more than anything i've ever tried, Plus this pot, does actually last longer than you might even realise, because the product is of such high quality, it spreads evenly, you use a lot less, it just goes so much further.
Ladies try this product!
I have used this product and so has a friend and we are both very impressed and just love it. All Caudalie products are great and especially the radiance serum. If you are getting on in years then get going on the radiance serum.
Caroline Bawden, Salisbury Wilts


text: Learn how to use video and email marketing to get your message across to clients. Understand the four key principles of successful video marketing as communicated. Learn best practices to incorporate video into your email & social media marketing, as we touch upon best practices for doing this. Presented by MiniMatters, Fee $25


text:
Stepping from the South Station platform onto the 8:05 a.m. commuter train to Plymouth and Kingston - one of the weekend trains the MBTA plans to eliminate - Carol Payne of Rome, Ga., noticed something seemed missing: passengers. Turning to her husband, James, she asked, "How many riders does it take for them to run this?'' The answer, according to the T, is a lot more than ride the train now. The train the Paynes rode to Plymouth for sightseeing Saturday could have been an exhibit for the T's cost-cutting plans. Four of the train's five passenger cars were closed off. At peak, the Paynes were two of only 13 passengers sitting in the more than 180 seats available in the sole open car.
BostonGlobe.comSubscriber Log-in
Contact us for help
- Phone
Monday-Friday 6:00 a.m.- 5:00 p.m.
Saturday, Sunday and Holidays 7:30 a.m.- 12:00 noon
- Chat
Monday-Sunday 8:00 a.m.- 5:00 p.m.
Your comment is subject to the rules of our Posting Policy
This comment may appear on your public profile. Public Profile FAQ


text:
Only reision why I dont like summer
I don't care about the weather, there's just no school.
♦ If I do not know you, I will not play online with you ♦
♦ The Fuchsia City Guru ♦
Going two screens is weird, at least now I can do two thinks at once.
Saw Promitas
That prequel to the Alien films
Twas great
I normally don't complain about my parent's actions too much, but when I take 2 jobs so that I can help spending money on top of trip money, I see no reason as to why I can't spend my spending money, let alone <25% of it.


text:
Falcon Anthology Series, Vol. 40 - The Best Of Colby Taylor, Vol. 2 FAS040
Scene 1
JVP108: Hooked
Colby Taylor and Lifetime Exclusive Matthew Rush have always been hooked on each other, but they've never had the chance to admit it. An innocent game of wrestling encourages them to finally
take the plunge.
Scene 2
MVP057: Up For Grabs
Colby Taylor and Nicholas Clay both stick their big dicks down Rick Matthews's throat while they kiss and lick each other. Then Colby and Rick lick and suck on Nicholas's tool, until Colby and Nicholas pin Rick to the futon. Colby fucks him deep in his ass, while Nicholas ferociously fucks Rick's face. Nicholas then takes his turn fucking Rick, while Colby shoves his dick in Nicholas's face as he watches Nicholas pound Rick's ass. They're soon blowing their loads all over the futon.
Scene 3
JVP100: Convictions, Part 2
When Nino Bacci and Colby Taylor get together, the chemistry is electric. Colby immediately buries his tongue in Nino's ass. Nino sucks on Colby's stiff cock. The two studs nurse on each other's pricks until Nino can't control himself and begins pounding Colby's ass. Nino pumps Colby until Colby shoots his load and then Nino sprays his own all over Colby's chest.
Scene 4
FVP121: French Connections, Part 2 - Conquest
Colby Taylor, Thom Barron and Matt Skyler
Scene 5
JVP087: Desert Hart
Colby Taylor likes it early in the day and he welcomes Shane Lancourt for a morning workout. The two men feed on heach other, running their hands and mouths over each other's bodies. They take turns sucking cocks and nipples, jamming their tongues inside each other's cracks...working themselves into a frenzy. Shane rides Colby's stiff hard prick, then together they stroke themselves to orgasm.
Scene 6
JVP121: Getting It In The End
Colby Taylor enters a seedy sex club and immediately eyes Roman Heart. There's instant chemistry as the two studs go at it. In the background, Tony Bishop, Blu Kennedy, Troy Apollo, Justin Gemineye watch the action while stroking and sucking their own meat.
Scene 7
FVP112: High Tide
Hiking through a tropical forest, Matthew Anders (in a non-sexual role) happens upon two other travelers—Michel Lucas and Colby Taylor. The two stunning young men are out enjoying the sights and each other…asking Matthew to snap their photograph amidst the natural splendor of a tropical forest. As soon as Matthew leaves, the couple decides to enjoy their own respective beauty. Colby services his eager friend, taking Michel's stiff uncut cock into his mouth, savoring the tool from tip to shaft, finally bathing his balls with broad sweeps of a soft but insistent tongue. In no time at all, Michel is on his knees returning the Colby's oral affections, his tongue wandering over the balls and into the crevice of Colby's ass, his finger probing the pucker of his hole. Raising him up, Michel fucks Colby hard and fast; he continues the erotic rhythm as the pair lay nestled in the back of their car. Frenzied, anxious for release, the two taut men stroke themsel
Scene 8
JVP078: Hot Wheels
When Jeremy and Eric arrive at Ethan-Michael's, they find a blindfolded Colby Taylor devotedly sucking Ethan-Michael's thick cock. Jeremy and Eric are quick to enjoy the hot action and begin stroking each other as they look on. Unable to restrain themselves, Jeremy and Eric join Ethan-Michael in feeding the hungry cocksucker their hot young meat. Eric fucks Colby as Colby rims Ethan-Michael and Ethan-Michael deep-throats Jeremy's aching cock. The four tight young studs continue their group fucking, rearranging themselves as their desires shift and mount, until finally each of the men spill their load over Ethan-Michael's tawny chest.
Scene 9
FVP179: Endless Crush
Tristan Jaxx, Mason Wyler, Todd Welch & Colby Taylor. This hungry quartet finds themselves poolside and itching to go. Tristan pairs off with Mason, while Colby takes Todd on and the two sets of eager studs compete to see who can out-suck, out-fuck, out-rim and out-sex the other, until they switch partners to carry on even more.


text:
10 days later…
Hello again!
It's been 10 days since we launched the first Beta of Skype 4.0 for Windows, so I thought it would be a good idea to reflect a little and to respond to some of the feedback we've received.
Firstly, I'd like to thank everyone who has given us their thoughts via our feedback site, on this and our other blogs, but also via the various feedback mechanisms we introduced for this Beta. It always amazes me how many people are so passionate about Skype and that's what makes it so enjoyable to get up and come to work every morning (apart from last Thursday – boy, did my head hurt).
We've had very different reactions to Beta 1, in particular the big change we made of having Skype in a larger window. One of the primary reasons for doing this was that we found an overwhelming majority of people had trouble working with multiple windows and were using Skype mainly to make calls and video calls, especially amongst those new to Skype. We've had some very positive feedback from a lot of people on the new way of working, and that's encouraging as it seems we're starting to solve the problems that we set out to solve. However, it's very understandable some of you used to using Skype on a regualar basis have been a bit frustrated about not being able to work with Skype the way they are used to.
We always planned to address our more advanced users in a second beta, and I just wanted to say – don't worry — we will address the need to have Skype take up less room on the screen with a feature that allows you to reduce the size – we call it compact mode. We hope to get it out towards the end of the summer with our second beta release.
]]>Other people have also commented on being able to resize video. There are a few things you can do here in Beta 1. Firstly, in the single window, you can resize both your own video and the video of the other person you are talking to. If you hover over the bottom left corner of the video feeds, you will find this functionality. What you can also do is pop out the video window using this button -> , which you'll see at the top right hand corner of your screen, to the right of the "+ Add people" button.
Which, will mean, if you're on a video call, you'll see something like this:
We will make further improvements to this with Beta 2.
Finally, a lot of people have asked about a Mac version. Both the Mac and Linux teams here at Skype are working closely with us on this Beta. They are reading all of this feedback and will be picking out the truly great bits and putting them into their respective versions. So you can certainly expect to see something on Mac after summer.
Again, thank you for your passion and you enthusiasm – and hopefully you are enjoying Skype 4.0 Beta 1.
Speak to you again soon.
Mike Bartlett
Director of Product Management, Skype for Windows
16 thoughts on "10 days later…"
xuyaoyork said 5 years ago
I installed the beta version as soon as it was launched, and returned to v3.8 a couple of hours later. I do think the new integrated window looks stupid, and what is more stupid is that there is no option to change to "classic view". Dropping "Skype me" mode is also a silly move. I am always using it and has made a lot of friends through it. I know there are complains about it but there are also people loving it.
I wish Skype could be smaller and faster. Audio/video qualities can still be improved. Skype has not been able to connect through my school wifi for months and there is no solution about it. Skype out rates can be made cheaper. I've been using Skype for years and I am now so disappointed to see such a new beta version. I will stick to my 3.8 until it is not supported anymore, if the final version of 4.0 is like the beta 1. -
alexleonard said 5 years ago
Well, I have to say that I feel the 4 Beta shows promise. It's quite a radical UI change and I can see that it might take a little while to become familiar with it, but the most important thing, in my mind, is that everything is in one place now (with the option of popping individual chat and call windows out from the main window if that suits you).
Definitely though I am baffled by a few things.
1. Why change the skype out contact icon colour to green? The old blue worked well and offered an instant visual separation of skype/skypeout contacts.
2. Obviously there are going to be things missing, but the lack of a history section (or at least a voice mail section) is a major downside. I am sticking with the beta on my desktop but use 3.8 on my laptop to check my history of calls etc. I can see that the aim is probably to integrate this old feature with the new conversations section – but it definitely needs some work.
3. I do like the new Profile/Location/etc section above each conversation window, but it does seem excessively large. I realise you mention an overall compact mode, but it would be nice if there were two minimised options, one of which kept a small thumbnail of chat participants. Visual clues are much easier than text for quickly glancing at a window to see who's involved.
4. I hope and assume that contact groups will be making a reappearance. I had only recently sorted out all my contacts to make it easier to be in "work mode". It's a shame that's gone now.
5. The Call Phones tab is extremely inflexible and doesn't like the window being sized down (starts chopping off your call credit listing)
One final thing – can we pretty please have an option to add our own images to people's profiles. Again, visual clues are much better, and I for one would love to see, when a skype out call comes through, a photo of the person that's calling. Again, it's that split second recognition thing that just makes it a nicer tool for communication.
Anyway, keep it up. I really hope with Beta 2 that when you say "towards the end of the summer" that doesn't mean September
September might seem like autumn to some people, but in Ireland it's often the best "summer month" from a weather point of view.
vitsom said 5 years ago
Hello, How to have a chat using Beta 1? I couldn't find it. If a payed SMS is an only option, I do not like it.
vitsom -
nafcom said 5 years ago
@vitsom: Right click on the contact –> Send IM
is one way to start a chat. -
don.goldman said 5 years ago
Can 4.0 beta be set to start minimized?
mrrobot1 said 5 years ago
Hey, where has Skype Prime gone on the 4.0 menus?
imandeep said 5 years ago
I love the Skype 4.0 larger video display and quality. It just blows away the competition. I wish it supported SIP.
One big issue that has been bothering me and possibly others is the inability to see my contacts online even though they are in fact online. I can't see them online and they can't see me online even though we both know we are both logged in properly to Skype. We have no problems with Google Talk but it looks like Skype is having big issues with this.
I would appreciate if something can be done about it as we simply cannot voice chat or video chat or in fact do anything if I cannot see my friends online and if they cannot see me.
cuberds said 5 years ago
I wish the Mac dev team would pay attention.
The Skypecasts don't work for Intel Macs running Leopard.
It's quite frustrating, please help fix this! -
biasuz said 5 years ago
Having trouble !!! can´t seem to start skype 4.0 beta in minimized stated… QTF!?! I´ts pretty annoying !!!!
Also having trouble finding my online friends actually online!!! Sounds stuped, but true.
nicolemiles86 said 5 years ago
I don't know who to tell this to, but I just want to say thank you you guys so much for Skype. It is such an incredibly great program. It has helped support my long distance relationship where I was calling the US from Japan and now I'm calling Denmark from the US. And it works so perfectly, and it's free too (or really cheap)! I find it almost too good to be true. Thank you so so very much.
-a very happy customer
skypeisrael972 said 5 years ago
סקייפ ישראל
תגיות:skype -
hubbardpeter said 5 years ago
This has nothing to do with any of the aforegoing blogs. Just a note of amazaement that I had to Google "Skype customer service telephone number" and work through a bunch of unhappy blogs about Skype having no customer service phone number (that is, that is made known to its customers). Anyway, I lucked out, as some persistent soul somehow had found out what the svc number is; which I will call tomorrow to cancel service. I tried cancelling by using email (within the Skype panel) a few days ago. Not even an acknowledgement. Boy, Vonage are nasty tricksters, but I thought Skype would be better. Happily, got an AT&T landline back in today, and am celebrating my re-entry into the world of telephonic communications! Goodbye forever to VOIP, and good riddance!
mvtcracker said 5 years ago
I don't like the new look I find it takes more time to find out who is chatting
I think you should install skype muter at the same time you install skype
(its free anyway)I think you should be trying to get more girls interested in skype since they tend to do more talking anyway (free skype to skype calling is great)
I also think you should have reviews on microphones/headsets/phones and coupons or discounts….
vankata963 said 5 years ago
Do You Know Something Cool Bulgaria Created A Leagle version of Skype 184.108.40.206 Becouse now Skype England is in version 4.0.0.094
Bulgaria Rulzz
Do You Know Than England Created Skype 3.7.6
And Bulgaria Created 3.8.0 Than Skype Added Bulgarian Skype In Their Site
Actualy Skype England And Skype Bulgaria Singend an contract so wait 4.2.64.000 by Bulgaria (flag:bg) -
vankata963 said 5 years ago
Download Skype 126.96.36.199 Bg Version Here: http://download.skype.com/SkypeSetup-Beta.exe
riccardo.cavallari said 5 years ago
I installed beta version and let me say that i don't like new look.
Buy the way, I tried to remove it to re-install 3.8 version, but now the old one does not work. the program closes automatically after 10-15 seconds….NO GOOD


text:
Wingate by Wyndham State Arena
Welcome to the brand-new Wingate by Wyndham State Arena Raleigh/Cary in Raleigh/Cary, a smart, modern lodging choice, conveniently located in Raleigh, North Carolina, only minutes from Research Triangle Park, the PNC Arena (previously RBC Center), the NC State Fairgrounds, Carter-Finley Stadium, and Raleigh Durham International Airport. We are also conveniently located near WakeMed Soccer Park in the nearby town of Cary. Our 100-percent smoke-free hotel offers numerous amenities and services for modern-day business and leisure travelers to the Raleigh, NC area, ranging from complimentary airport & PNC Arena shuttle and indoor swimming pool & whirlpool, to complimentary breakfast daily, an on-site fitness facility featuring Precor equipment, and complimentary high speed Internet access.Accommodations -
Numerous complimentary amenities make the Wingate by Wyndham State Arena Raleigh/Cary an ideal choice for business travelers. Begin your day by working out in our on-site fitness center featuring Precor equipment. Follow it up with a complimentary hot breakfast and your own complimentary newspaper. Complimentary wired and wireless Internet access will let you tie up any loose ends at work. Utilize our 24-hour business center that offers free faxing, copying, and printing services to print your boarding pass. For your meeting needs, the Wingate offers over 1200 sqft. of flexible meeting space perfect for thecorporate client.
Hotel Near North Carolina State Fair -
The Wingate by Wyndham is the ideal place to stay for individuals and groups coming to see events at the PNC Arena for a weekend get away.Guests of the new Wingate, a Raleigh, NC hotel, enjoy close proximity to the PNC Arena, home of Carolina Hurricanes and the NC State Wolfpack, as well as easy access to NC State University, Meredith College, WakeMed Soccer Park, the Triangle Aquatic Center, Dorton Arena, the Hunt Horse Complex, USA Baseball Complex, Cary Tennis Center, shopping at Cary Towne Center and Crossroads Shopping Complex and the historic downtowns of Raleigh and Cary Town.
For your convenience, our hotel offers refrigerators and microwaves in every room, heated indoor pool and whirlpool, complimentary breakfast daily and complimentary Internet access. It all adds up to a hotel experience that's low on stress and high on service. Come visit the Wingate by Wyndham State Arena Raleigh, North Carolina hotel and see for yourself!
*For GPS, please use 600 Corporate Center Drive, Raleigh, North Carolina 27607


text:
Synopsis: This documentary takes a look at the phenomenon of crossdressing in film - an idea that consistently evokes strong reactions from audiences, and makes for bankable entertainment. Looking back on its playful history, the film features interviews with people like John Waters and Tim Curry. ~ Cammila Albertson, Rovi Continue Reading
Starring: RuPaul, John Landis, John Waters, Tim Curry


text:
Evening Lecture: "Stone Houses: Traditional Homes of R. Brognard Okie"
Wednesday, December 4
6:00 pm, Copeland Lecture Hall
The middle region of the eastern seaboard is a particularly rich area for the study of traditional building in masonry. One of the most interesting practitioners was Richardson Brognard Okie, Jr., whose appreciation and understanding of early American domestic architecture had a lasting impact on American residential design. His combination of high and low styles made the later revival architecture both richer and more accessible to people from inside the area as well as those far beyond the original boundaries of the region.
Join James B. Garrison, architect and author of Stone Houses: Traditional Homes of R. Brognard Okie , to learn about his early work in the colonial revival style, relying on applied ornament as well as creative solid geometry, to his evolution toward an even more personal style with less ornament. His architecture and the related work of his predecessors and successors is part of a continuous tradition of building that relates local materials and inspiration to universal principals. Lecture and book signing; free.
"Costumes of Downton Abbey (Members Only)"
Sunday, January 5
1:30 & 4:30 pm, Copeland Lecture Hall
Season 4 of the Downton Abbey television show premieres on January 5. Get yourself in a Downton Abbey state of mind with this Members-only lecture. Estate Historian Maggie Lidz gives an inside look at her trip to Cosprop in England in search of costumes for the upcoming exhibition opening in the Galleries March 1, while Director of Public Progams Jeff Groff highlights the men's costumes, including sporting life, country life, and evening dress. Reservations required. Call 800.448.3883 for reservations.
"Kirstenbosch, The Most Beautiful Garden in Africa" with Brian Huntley
Saturday, February 1, 2014
10:00–11:00 am, Brown Horticulture Learning Center
Kirstenbosch is a name that resonates across the horticultural and gardening world as the home of a uniquely beautiful flora in a setting of unsurpassed beauty. Situated at the southern tip of Africa in the epicenter of the famously rich Cape Floral Kingdom, Kirstenbosch has been admired by visitors for more than 200 years. As executive director of the South African National Biodiversity Institute, Brian Huntley tirelessly promoted and improved Kirstenbosch (and the eight other botanical gardens he directed). In this richly illustrated talk, Professor Huntley will share his insights about botanical exploration and discovery, Kirstenbosch, and South Africa. Free. Registration recommended due to limited seating. Parking available at the Brown Horticultural Learning Center (look for parking signs as you enter).
Student Lecture Series
Master's Thesis Research Inspired by Winterthur: "Practicing Handwriting in the Nineteenth-Century and Furnishing the 'Frontier'"
Friday, December 13
12:15 pm, Rotunda
Alexander Ames and Lauren Brincat, McNeill Fellows, Winterthur Program in American Material Culture, describe their summer research as part of their master's theses. Alex is inspired by examples of German-inspired script called Fraktur, made by Johannes Bard of Adams County, PA. His project, "Heavenly Handwriting, Teutonic Type: Rethinking the Many Meanings of Pennsylvania German Fraktur, c. 1750-1850," investigates the cultural and intellectual context of various traditions of written communication. His research causes him to consider the place of handwriting instruction in the 21st-century classroom. Lauren studies the home and objects of English, Dutch, and Huguenot settlers in Flushing, New York in ""Flushing's John Bowne House: Furnishing a Frontier." A frontier for settlers in the 1600s and early 1700s, this section of New York City is a laboratory about how history can be meaningful to the diverse residents of 21st-century Flushing. Brown bag lunches welcome. Members free. Included with admission.


text:
Half the Oil: A Plan to Cut Projected U.S. Oil Use in Half in 20 Years
We have the practical solutions at hand to protect consumers, the climate, and our environment from the growing costs of our oil use.
How? It all comes down to one simple fact:
Using less is the real oil solution.
By cutting our projected oil use in half, we can save money, create jobs, protect our health, lower global warming emissions, and establish America as a global leader in transportation technology.
We can do it! And we can do it over the next 20 years with improved fuel efficiency and innovative alternatives to oil. The Half the Oil Plan shows how.
Join the campaign today — and together we'll move the country forward toward a Half the Oil future.
Take Action! Cutting Oil Use Is the Real Solution
See the Half the Oil Plan in Action
Using less oil is practical, achievable, and benefits us all. Yet one powerful group is intent on blocking progress. Who's standing in the way? See for yourself.
How Does the Half the Oil Plan Work?
The Half the Oil Plan slashes oil use by tapping into efficient technologies and putting innovative solutions to work:
Increasing the fuel efficiency of our cars and trucks. Unleashing the full potential of electric vehicles. Investing in the development of better, cleaner biofuels. Building smarter, more diverse transportation systems.
It's all possible with technologies already available or just around the corner. Now we need bold action — from our leaders, from our communities, and from individuals like you to make real progress on cutting our oil use.
Join the Campaign. Take Action Now!
- Urge the President to follow through on the commitments he made in his Climate Action Plan.
- Visit our What You Can Do page to discover more ways to voice your support for Half the Oil solutions and learn how you can reduce your own personal oil use.


text:
You're watching...
Mulally: Good Time to Increase the Dividend
Ford CEO Alan Mulally on the debt-ceiling negotiations and how he believes new Ford leadership will help the company.
Jan 14, 2013
You're watching...
Ford CEO Alan Mulally on the debt-ceiling negotiations and how he believes new Ford leadership will help the company.
Jan 14, 2013
Also in this playlist...
Auto-advance: ON
Auto-advanceThis transcript is automatically generated
For investors in the Ford Motor Co.
that stock hitting -- 52 week high last week and now Alan Mulally the CEO is looking to shift focus to the luxury Lincoln brand with a whole new vehicle at Jeff Flock -- who.
From the North American auto show.
Did try -- hey -- I'm.
Sitting down with Alan Mulally is taken a moment to just catch his breath after six years how many years is -- six years -- Six years of hell raising in Detroit.
I don't say it's come into it.
You know until you.
You're a when you started showed up with you know sport sport -- White you know white -- It's gray slacks blue blazer.
Take a look more can you see what he's wearing down her just take a walk.
Could she actually what you've got on come on now you give us a -- penetrated interview by fox stupid pig pen I'll.
This is where we soften -- up and and we ask you about the deaths and.
He's been so we suggested the you know -- my conservative attire I might wanna step up with a you know a couple of snazzy socks so.
Nicely done.
OK let's start with this report for President Obama -- -- -- a press conference talk about debt ceiling analysts are sick of all this foolishness in Washington or what.
We -- Jeff one on one hand like give to get resolved faster.
-- rather than later.
On the other hand I'm just so pleased that the debate has moved into the bigger issue that is how we live within our means how we gonna bring down the debt.
How -- you bring down the budget deficits.
-- we're gonna really do about the trade deficits so we can create an economy again.
That is growing for the good of all assess the most important thing I think -- -- -- -- what you're saying there if the Republicans need to shut down the government don't raise the debt limit until we get meaningful spending cuts is that what you're saying I think this is so important that we move to a comprehensive strategy to -- -- economic development in the United States.
That's the most important thing we do for all of us.
And would you if if you -- -- would you work -- Obama administration.
All I'm very I've been very pleased support the administration this administration the previous one.
Because that public private partnership especially for men -- -- -- United States especially with the trade rules around the world.
I've been very pleased to be asked -- be listened to be part of the solution I mean a real job.
Well I think the best thing that I that I can do -- I feel really good about this is serving border where.
There were clearly the heart and soul and work is done sir you've done it a -- -- -- just giving you really getting started -- we are.
It is a very important part of the United States economy.
This nearly 15% of our GDP.
And -- percent of all the research and development the United States is associated with manufacturing so.
I'm very pleased to -- -- you have just named a new chief operating officer you never had that before your -- you know you're the operator yourself.
How does it feel it's a great reporter question how does that feel.
Well you know -- they're really feels a great.
Because you know clearly one of the things that I've focused on is further developing the entire team afford worldwide.
And I'm so pleased with this latest step of asking mark to be the chief operating officer also John Hendricks has come back from Asia Pacific to take over the Americas.
Stephen -- -- them take over Africa as well as the Middle East and Europe.
And of course we have Dave shock these fantastic operator in Asia Pacific now he and maybe the biggest one.
Is Jim Farley who really knows luxury is not only not only leading sales -- -- service -- why but also Lincoln so.
You paint a more now Jamaican do double work.
I think he felt fully appreciate -- we appreciate him but I think this whole idea.
Not only give up in the team members individually but also them as a team is -- -- Ford really well speaking of paying people.
Dividends you just doubled it.
A lot of the Ford family like that Corsica -- but so all the stockholders -- -- say about your stuff.
Well Jeff by the guess again as a really important proof point about the when Ford planned because.
We also share and everybody that we were gonna reinstated dividend and -- -- plan was that we gave -- continue that dividend even during a recession.
Because that consistency of purpose that clarity was really get -- so not only do we reinstated last year.
But we just announced so we're going to be -- it.
Which means it shows you how we feel.
About our ability to generate free cash flow and grow the business over the long I was gonna say some people question is that a good way to spend your money you feel like you've got enough money to spend on new product is well absolutely and part of their capital allocation process says there's -- -- uses offense number one.
The new product development planned around the world.
Also everybody profitable growth for everyone including the shareholders and so.
We looked -- our liquidity we looked at our debt all the prior -- bringing down our debt and we think this they're really good time to increase the dividend.
Who's in charge of four by the way.
In charge of Ford -- who's in charge of -- well I think it starts with the board of directors and bill Ford with his able assistant Alan.
And you said you will be there at least -- Tony fourteen.
I did and I I think that.
That's a really good guidance that we still I believe in that because who want to further develop the team for the develop the strategy of have this balanced portfolio serving all markets around the world as well as -- a world class full family vehicles and so.
In a way we're just that you're really picking up the pace of implement -- when Ford plant.
I can not wait till the next time we talk and I see what your wearing on your on your feet.
At one shot deal -- the big change -- It is not a big change is -- forward mirrors the -- -- Mulally always great to see -- thanks very much.
Now to the president perhaps we but the next member of his cabinet.
-- about bought back that's pretty good Jeff.
Those are not just data and I -- and.
Filter by section


text:
A new journal that publishes peer review comments alongside its manuscripts goes live.
A new journal that publishes peer review comments alongside its manuscripts goes live.
A small insect-eating animal is the common ancestor of whales, elephants, dogs, and humans.
Why so few scientists make the leap to policy-making positions, and why more should give it a try
Globally, 15-year-old girls outscored boys in 43 of the 65 countries tested.
In Chapter 1, "A Theory," author Aaron James constructs a working definition for the type of person that earns the ignominious moniker.
Harvard geneticists and anthropologists challenge the work of two economists who say there's a link between genetic diversity and wealth.
A new study disputes findings of a 2011 analysis suggesting that black researchers are funded less than their equally qualified white peers.
The Science of Love, Bad Pharma, Genes, Cells and Brains, and Nature Wars
Meet some of the people featured in the February 2013 issue of The Scientist.
A handful of species have learned how to survive in freezing climates. To do so, the animals must counteract the damaging effects of ice crystal formation, or keep from freezing altogether. Here are a few ways they do it.


text:
whoa....i still dont know why the money-grubbing old white man has possession of this land to begin with....what insane fool/s took many-times hallowed ground and sold it to him?? or did i miss something...
Owner of Wounded Knee Eager to Sell to Johnny Depp
Deep in this Daily Mail feature on Johnny Depp, the actor who portrayed Tonto in Disney's Lone Ranger re-boot expresses a desire to buy the site of Wounded Knee and return it to the Oglala Sioux Tribe. While landowner James Czywczynski and tribal president Bryan Brewer say the purchase would be a noble gesture, neither have heard from Depp.
"It's very sacred ground and many atrocities were committed against the Sioux there. And in the 1970s there was a stand-off between the Feds and the people who should own that land," Depp told the Daily Mail. "This historical land is so important to the Sioux culture and all I want to do is buy it and give it back. Why doesn't the government do that?"
Brewer, upon hearing the news from Indian Country Today Media Network, welcomed the possibility and said the tribe would be more than willing to meet with Depp. "The fact that Johnny Depp would say this is really something," he said. "If he would like to speak with us that would be great. We certainly appreciate his concern for this matter and the respect he is demonstrating to our people. The possibility of his goodwill effort toward keeping this land intact and in tribal hands is amazing."
When Czywczynski put the site on the open market for $3.9 million in May, he never imagined the international exposure he would receive. He certainly never expected a celebrity like Depp to get involved. "I just got the news about [Depp's interest] an hour ago and I don't know what to think about it," he said.
Czywczynski reiterated that his top priority is that whoever purchases the property give it to the tribe. "I really don't care who buys it and donates it to the Oglala Sioux Tribe as long as somebody does it," he said. "Johnny Depp has a lot of money. He could probably raise this money in a heartbeat. So I was kind of glad to see some national and international exposure."
Czywczynski said there are a few anonymous donors attempting to raise the money to buy the site for the tribe. "Right now we have several possible donors. There is someone on the West Coast... We are also working with another group and now this has come up. So there are three or four groups right now. I guess whoever comes up with the money first is going to be the winner."
Brewer, meanwhile, said the tribal council is still attempting to reclaim the site through legal means. "Our tribal council wanted to try and get this land back through the court system because they feel that this man [Czywczynski] will get so much money over what it is worth. Whoever purchases this land will never be able to use it because it is surrounded by tribal land. They would never get an easement to use it for anything. James Czywczynski said he was going to put this land up for sale, the deadline passed and no one bought it."
When asked what she thought about Depp buying Wounded Knee, Georgine Looks Twice, of the Tribal Land Office, said: "This is awesome—I was really waiting for someone to step forward… More than anything, I just want to get to see him."
But as the Daily Mail asked, is Depp really prepared to buy the land? "I am doing my best to make that happen," the actor told the paper. "It's land they were pushed on to and then they were massacred there. It really saddens me."
If Czywczynski is the land
If Czywczynski is the land owner, and he has stated that whoever purchases the property must give it to the Ogala, why doesn't he just donate it back to the Oglala Sioux Tribe himself? No one should purchase this land.
James Czywczynski is
James Czywczynski is pretending to be honorable, meanwhile all he wants is money. Czywczynski -- a bolder statement would be to give the land back yourself, you KNOW what is right, don't wait for someone else to make the right move, you are the one with the deadline James.
tribe should reclaim by law
tribe should reclaim by law (suit) and get its costs to do it. should be some pro bono lawyers out there to help. if not i'll help find some.
jonny depp is worth probably
jonny depp is worth probably 100 mil or more.. 4 mil dollars is like nothing to him..its just another boat or toy in his world.. .. The lone ranger movie stunk, but if jonny finds it in his heart to settle this whole thing and then give this land back to the tribe then that would be a good and noble thing to do..... I hope it happens and the tribe can do something good with the property
I remember the questions they
I remember the questions they used to ask in math class. I remember thinking, "When in the world will I ever have to calculate at what time, and in what city two trains will meet up?" The case of Czywczyuski reminds me of those old math questions.
Question 1: Does Czywczyuski currently pay or owe taxes on the land he wants to sell?
Questions 2 and 3: If he pays taxes, what does the IRS base his tax rate on? Is it the value of the land at $14,000 for both parcels?
Question 4: Czywczyuski doesn't care who buys it, so long as they give (underscore "give" here) it to the Oglala, right?
Math question: Tell me please, do you have to pay taxes on a gift that you own? How much does Johnny pay in taxes if Johnny owns something valued at $4.3 million dollars? How much does Johnny's neighbors pay in taxes because the value of what Czywczyuski wants to sell has--in polite circles--more than doubled in value? If Johnny and his neighbors can't pay their taxes, what happens to their land? Could the government sell it for the taxes owed—and revalue the land for less? If the taxes owed equal $4.3 million or less, well only a millionaire with $4.3 million could buy it…but who…who in the world has THAT kind of money??
Those old math questions seemed hard at first, but once you figured out the answer to them a couple of times, answers to other questions like them just seemed to fall into place. But what's the answer to the math question above?
Answer: Czywczyuski's revenge...
Analysis: No one should pay a dime to this man for that land.
General America, of which I'm
General America, of which I'm a part, has no idea about the trials and tribulations you guys (Native Americans) go through. I am sympathetic, empathetic and emphatically horrified, so, I listen and ask questions, whenever the opportunity arises. I think our government (the States) should shoulder the responsibility for this type of ordeal, but what will it take? People like Depp are helping the situation by kindling interest, and time will tell if those people follow up.... or not. What will it take? To wake our government up. This may seem wrong or oversimplified. I can only see it from my point of view. Lobbying? Petitions? I believe if the average american were aware of this situation, for instance, they would vote for the landowner to give it back, or the government should take a look at the poverty, etc, and stop doing nothing.
Well whomever buys it needs
Well whomever buys it needs to have the U.S government pay them back for it since it shouldn't be for sale since it wasn't legally purchased and the Oglala Sioux still have ownership rights.
The "KISS" method, (keep it
The "KISS" method, (keep it simple stupid) needs to be applied here. Plain and simple, you can not buy what is not owned. No one owned the land that the government claimed was theirs. Then they claimed ownership, and sold it, in many instances to people that couldn't afford it. So.... Their plan began. The great so called American dream, "Debt". Something that our government has failed horribly at themselves. I don't play into any of this. It is what it is now. We all need to stop buying into this. One day the "dream" is going to turn into a nightmare. Karma.
It's obvious. This
It's obvious. This Czywczynski fella just wants to raise enough money to buy a vowel.
if every piece of land that
if every piece of land that an Indian was killed on had to be given back to the tribe, there wouldn't be any land left! stop your effin' whinin' and go get a job! by the way Gambling and getting drunk are not considered jobs. the indians were a conquered people and after that they gave up! grow a pair...and stand up and be proud! you keep yourselves segregated from the world but when you need help you sure call on the world to help. sick of it! Oh, and finally, clean up this wonderful, Holy, Sacred ground that you have! you tribes are a joke....just like the effin' blacks! ITS BEEN @)) YEARS>>>GET OVER IT!
The property is land locked?
The property is land locked? .No easement??? How did that happen. How'd jc get the land to begin with? should start there first.
Why doesn't this Czywczynski
Why doesn't this Czywczynski just give back the land himself without asking money? Or is it because he doesn't care THAT much what happens to it.
Its about time someone does
Its about time someone does what is right. let us just hope that it will be done and the spirits of those who died there will be finally at peace.


text:
ABOUT SOLAR CELLS: In the future, more homes will most likely incorporate solar cells, also known as photovoltaics. Solar cells are made of semiconductor materials (usually silicon), which absorb sunlight's energy and stores it until it is needed to power something. Unfortunately, present solar cells can only absorb between 15-25 percent of sunlight's energy. This is because they absorb only visible light; other kinds of light pass right through the cells as if they were transparent.
HOW CAN HOMES CONSERVE ENERGY? There are many ways in which houses can conserve energy. Improvements in energy-efficient lighting can reduce power usage by as much as 65 percent. In fact, if every American household changed just five of the most-used lighting fixtures to energy-efficient technology, they would save a total of $6 billion and reduce power usage by the equivalent of the annual output of more than 21 power plants. Many homes have high-performance, energy-efficient windows -- featuring double glazing or special coatings -- to reduce heat loss in cooler climates and heat gain in warmer climates. These two factors account for 50 percent of a home's heating and cooling needs. Replacing window frames with low-conductance materials like wood, vinyl and fiberglass can also improve a home's insulating capability
The AVS, the Science and Technology Society, the Optical Society of Americaand the Materials Research Society contributed to the information contained in the TV portion of this report.


text:
since we're only 2 players in this game, i doubt this thread will help much, but I think is good to summarise:
Game Rules:
Default rules + :
no Do or Die
Random events
Non-Blind Research
Look First
-No turn restarting
-No commlink before contact
-No going into F1 => Factions to see what factions you're up against (relevant only when there are Random factions in game)
-Only one SE change/turn/line
Bugs/Features LIST:
-18 (Reverse Engineering)
-21 (Unload in Flight)
-26 (no Vendetta after Stealing) : as Dreifeils wrote:
A probe team operation is a secret service operation and it's just the character of a secret service operation that the victim doesn't see / know it and has no possibility to act at once.
35-(Sea Artillery Combat)
44/45 (Stockpile Energy Bug)
What does not the website says is that AFAIK the stockpile energy bug ALWAYS works for facilities!
63-(Upgrades in Workshop): OK, but without attacking the same turn!
76-(fire Artillery from Transport)
(Transport in Sea Base Trick):
When you put a transport (sea or land(air?) in a sea base near a coast (and on the coast near a sea base?) you can transfer units from coast to base and inversely. The transport itself can also move from base to coast and inversely.
(Unit Sea/Cost transfer with help of another Unit):
When you put a unit on a coast near a sea base another unit can move from the base to the square where the 1st unit is (and inversely?).
(Transport Floating Bridge)
If you board a sea Transport with a land transport and move with the sea T out of the square, the land T will stay "floating" on the sea square! Repeating this you can make a bridge with land T!
(Upgrade crawlers for SP's.)
1-(Growth w/ColonyPod over the maximum possible size)
2-(Multiple AirDrop)
4-(AI unfair Base Trade)
7-(Restart bonus)
16-(Editor Cheating)
19-(Probe to Rover Reverse Engineering)
22-(Terraformer Move-Again Trick)
25-(AI Withdrawal)
27-(Erase Vendetta Trick)
38-(Industry Switching with Crawlers Disbanding)
42/43-(Planetary Council Bribes) : We should make all elections/votes/bribes by e-mail first.
50-(Facilities in Queue trick)
65-(Air Defense with Vendetta only): It should be also for Nothing/Truce/Treaty unless the other side gives approval.
71-(Terraforming Credit Up)
72-(Spying on Commlink Communications)
74-(Instant Patrol Upgrade Cheat)
75-(Citizen Remote Control)
I sent my password to the CMN archive:
under the title of of "Lone Island - gaia(bluetemplar) - password"
I might also send next turn game files (Planet Cult turns) occasionally...
Last edited by bluetemplar; March 19, 2006 at 22:00.
2103 e-mailed to bluetemplar
2104 e-mailed
2105 e-mailed. I really have to learn more emoticons.. hehe
2106 e-mailed
2107 e-mailed.. can't think of an appropriate emoticon
2108 sent.. I'm not dead yet! Yay!
Not ... YET !
Turn 2109 mailed to the uncharacteristically evil Gaian..
I'm peaceful! I just want to commune with Planet! Leave us alone!
Lal got the elections... 12 vs 2/3/4 ...
2110 mailed.. Lal looking a juggernaut. Not sure what I'm doing wrong, but bluetemplar is already blowing past me on the power graph. Ah well
Lal !
2111 sent
I don't know if you have the same thing, but I have a base without defenses and 2 pop and it still has no drones!
Since we are in transcend (i remember cllicking "transcend"!?), how could it be?
Or maybe it's because the map is small?
That is quite odd.. I've not heard of that happening before, and I'm too scared of drone riots to test it myself. 2112 mailed.
2113 mailed..
Does it have lots of energy? And are you allocating energy for psych? that could explain it.Originally posted by bluetemplar I don't know if you have the same thing, but I have a base without defenses and 2 pop and it still has no drones!
no energy for psych so far...
Turn 2114 mailed... I've clearly got quite a bit to learn about this game.. way behind on the power graph now.
soon i think...
2115 mailed. Looking forward to continuing this tommorow. I think I like PBEM
It will not be always that fast...
you forgot to attach the file...


text:
| 112 Meet & Greet Montreal Meet and Greet 112 live and in person. Get a photo with all 4 members. Only 100 tickets available.Purchase of Meet and Greet ticket does not gain access to the performance. 112 Equally rooted in gospel, soul and hip-hop, 112 was the first and most successful urban vocal group to emerge from Sean "Puffy" Combs'...[more] | |
| Thursday
3 Four All ThursdaysBy Resident DJJohnnyinfamous$3 Hiballs, Tequila andSouthern ComfortPlus Enjoy The Hottest Mash Up Rock+Dance+Retro+Top 40Stay Tuned As Johnny Is Joined By Many Great Local & International DJ's!...[more] | |
| Friday
Good Friday
Union Hall
Every Friday
Free Admission and Immediate Entry for Ladies Until Midnight!
Present this for priority entrance & free admission before 10:30pm.
Doors at 9:00pm....[more] | |
| Saturday
Celeb Saturdays
Union Hall
Every Saturday
Three olives Vodka until Mid night $3,
Present this for priority entrance & free admission before 10:30PM.
Doors at 9:00PM....[more] | |
| Sunday
Long Weekend SUNDAYS @ Union Hall
Always a special event or customer appreciation party happening every long weekend at the Hall. Stay tuned and check the website for more info.
...[more] |
Address: 6240 - 99 Street
Edmonton AB Canada (South)


text:
Links to share this album
Phylicia Simone Barnes visited her half-sister in Baltimore MD from her home in Monroe NC, where she was a high-school senior honor student. Phylicia was last seen Dec 28, 2010. Her body was found in the Susquehanna River at the Conowingo Dam April 20, 2011. Justice would catch up a year later when her murderer was arrested and charged on April 25, 2012. Michael Johnson's trial began 1/22/13, ended 2/6/13 with a guilty verdict. On 3/20/13 Judge Nance ordered a new trial for Johnson.


text:
Anything new on the block? I was seconds away from pulling the trigger on the schneider platinum IRNDs but then I read a really bad review...
Currently in a city with only one rental house (panavision Calgary) so testing a variety is pretty much out of the question.
I've been putting this off for too long and REALLY need a set of IRND/Hot Mirror/White Water etc NDs


text:
Toyota Division Communications
Greg Thome (310) 468-3279 or email@example.com
Sam Butto (310) 468-7728 or firstname.lastname@example.com
Scion Public Relations
Craig Taguchi (310) 468-3282 or email@example.com
Lexus Public Relations
Nancy Hubbell 310.468.7633 or firstname.lastname@example.com
Allison Takahashi 310.468.5315 or email@example.com
Bill Kwong 310.468.3764 or firstname.lastname@example.com |
Copyright Notice
All materials on this site are for editorial use only. The use of these materials for advertising, marketing or any other commercial purpose is prohibited. They may be cropped but not otherwise modified. To download these materials, you must agree to abide by these terms.


text:
If you placed an order on ApplianceHelp.com the order is still valid and you can check on its status and make changes here on PartSelect.com. Click here for more details.
PartSelect Number PS1532376
This part works with the following brands: Frigidaire, Gibson, Kelvinator, Kenmore, Tappan & White-Westinghouse.
Get this part fast. Average delivery time via regular ground: 1.8 days.
Provided by PartSelect customers like you.
Level of DifficultyReally easy
Time to do repair:Less than 15 mins
ToolsScrew drivers
CustomerDebra from San Diego CA
It was really easy! Just snap off the trim above and below the handle, unscrew the old broken one, and replace it with the new one. Then snap the trim back on above and below the handle. My husband wanted me to call a repair service to come out and take care of this. It would have taken two visits, the wait time in between, and the cost for the visits and the labor. I paid a bit extra to have overnight delivery and fixed it myself in less than 15 minutes! I will definitely use PartSelect in the future!
Were these instructions helpful?


text:
November 18, 2013 –
Kanye West Tour
Kanye Cancels, Reschedules Tour Dates
The Kanye West "Yeezus" tour needs a miracle. After technical problems and God - er, Kanye - knows what else, a new show schedule … read more →
Drake Bulldogs Football Tickets
Sorry! Looks like there aren't any events.
But it's not the end of the world! Click Track above and you'll be the first to know when Drake tickets are available.