text:
Laboratory/Animal/Preclinical Studies
Effects of Newcastle Disease Virus on Human Cancer Cells
NDV and Cancer Immunotherapy
Effects of Newcastle Disease Virus on Human Cancer Cells
The ability of Newcastle disease virus (NDV) to replicate efficiently in human cancer cells has been demonstrated in both laboratory studies and animal studies.[1-12] Reviewed in [13,14] Several of these studies have provided much of the evidence that lytic strains of NDV are also oncolytic.[3-6,8-10,12] Reviewed in [13]
Strain 73-T, which is lytic, has been shown to replicate efficiently in human tumor cells [15] and kill the following types of human cancer cells in vitro : fibrosarcoma, osteosarcoma, neuroblastoma, bladder carcinoma, cervical carcinoma, melanoma, Wilms tumor, and myeloid leukemia;[3,6,8,9] however, this strain did not kill human B-cell lymphoma (i.e., Burkitt lymphoma) cells in vitro.[8] In addition, strain 73-T did not kill normal, proliferating human white blood cells or normal human skin fibroblasts in vitro,[3,6,8] but it killed normal human lung fibroblasts in vitro at the same rate that it killed cancer cells.[8]
Lytic strain Roakin has been reported to kill human B-cell lymphoma cells and T cells transformed in vitro from a Hodgkin lymphoma patient four to five times faster than it kills normal, resting human white blood cells.[4,5] This strain, however, has also been reported to kill normal, proliferating human white blood cells in vitro, though at a lower rate than it kills cancer cells.[4]
Lytic strain Italien (or Italian) has been shown to kill human squamous cell lung carcinoma, melanoma, breast carcinoma, and larynx carcinoma, but not cervical carcinoma, cells in vitro.[12] The replication efficiency of this strain in normal human cells was not tested.
Overall, these results show that there are some types of human cancer cells in which individual lytic strains of NDV do not replicate very well and that there are some types of normal human cells in which they replicate very efficiently. Nonetheless, these data and the absence of serious illness in individuals infected with NDV Reviewed in [1-3,10,13,16-21] are consistent with the view that NDV replicates much more efficiently in human cancer cells than it does in most types of normal human cells (i.e., "DBTRG.05MG human glioblastoma," "U-87MG human astrocytoma,"[22] "rat F98 glioblastoma cells,"[23] and "mouse Ehrlich ascites carcinoma").[24]
NDV strain Ulster, which is nonlytic, has also been shown to replicate efficiently in human cancer cells in vitro, including cells of the following types of human tumors:
- Colorectal carcinoma.
- Gastric carcinoma.
- Pancreatic carcinoma.
- Bladder carcinoma.
- Breast carcinoma.
- Ovarian carcinoma.
- Renal cell carcinoma.
- Lung carcinoma.
- Larynx carcinoma.
- Cervical carcinoma.
- Glioblastoma.
- Melanoma.
- B-cell lymphoma.
- T-cell lymphoma.
This strain does not replicate very efficiently in resting or proliferating normal human white blood cells in vitro.[7] Other experiments have shown that NDV Ulster can kill infected cells [25] Reviewed in [14] and that it can replicate in human cancer cells whether they are actively proliferating or not.[7] Reviewed in [20]
The ability of lytic strains of NDV to kill human cancer cells in vivo has also been examined. In xenograft studies, human cancer cells were injected either subcutaneously or intradermally into athymic, nude mice (i.e., mice that do not reject tumor cells from other animals because they have a defective immune system), and tumors were allowed to form. NDV was injected directly into the tumors, and tumor growth and animal survival were monitored.
Intratumoral injection of strain 73-T was associated with complete tumor regression in 75% to 100% of mice bearing human fibrosarcoma, neuroblastoma, or cervical carcinoma tumors.[1-3,10] Intratumoral injection of 73-T was also associated with more than 80% tumor regression in 66% of mice bearing human synovial sarcoma tumors.[2] In addition, intratumoral injection of 73-T was associated with 68% to 96% inhibition of tumor growth in mice bearing human epidermoid, colon, lung, breast, or prostate carcinoma tumors.[10]
Intratumoral injection of strain Italien was associated with complete tumor regression in 100% of mice bearing human melanoma tumors. The growth of metastatic tumors in these animals, however, was not affected, suggesting that the virus was unable to disseminate widely throughout the body.[11] Reviewed in [14,20]
Replication of strain 73-T in the above-mentioned neuroblastoma xenografts was demonstrated by showing an increase in the amount of virus that could be recovered from tumor samples over time.[1] When this strain was injected into the thigh muscle of athymic, nude mice, the amount of virus that could be recovered decreased with time,[1] a finding consistent with the proposal that NDV replicates much more efficiently in cancer cells than in most normal cells.
Another study of intratumoral injection used the V4UPM strain of NDV in a nude mouse model of tumors produced by subcutaneous injection of human glioblastoma multiform cells.[22] All four mice with tumors from the U-87MG cell line experienced sustained complete responses after one injection. However, no complete responses were observed in mice with tumors from the DBTRG.05MG cell line despite a similar in vitro cytotoxicity compared with U-87MG.
In one study, mice bearing human neuroblastoma xenografts were given single intraperitoneal injections of strain 73-T, and 9 (75%) of 12 treated mice exhibited complete, durable tumor regressions.[10]
It is important to note that athymic, nude mice still make small numbers of T cells, and they produce interferons, natural killer cells, and macrophages. Reviewed in [11,26,27] The possibility that these residual components of the immune system, which may be activated by the presence of NDV, contributed to the antitumor effects observed in the xenograft studies cannot be ruled out.
NDV and Cancer ImmunotherapyOther laboratory and animal studies have shown that NDV and NDV-infected cancer cells can stimulate a variety of immune system responses that are essential to the successful immunotherapy of cancer.[6,8,25,28-42] Reviewed in [11,20,43-47] A few of these studies used human cells,[6,8,29,30,38,41,42] Reviewed in [20,44,47] but most used animal cells and animal tumor models.[6,8,25,28,30-37,39] Reviewed in [11,20,43-46]
Two in vitro studies have shown that infection of human immune system cells with NDV causes the cells to produce and release the cytokines interferon-alpha and tumor necrosis factor (TNF)-alpha.[6,8] In one of these studies,[6] it was shown further that infection of human cancer cells with NDV makes the cells more sensitive to the cytotoxic effects of TNF-alpha.
Additional in vitro studies have shown that NDV-infected human cancer cells are better at activating human cytotoxic T cells, helper T cells, and natural killer cells than uninfected cancer cells.[8,29,30,48] The NDV protein hemagglutinin-neuraminidase, which is present in the plasma membrane of virus-infected cells, appears to play a role in the enhancement of T cell activation. There is evidence that this protein makes infected cells more adhesive, thereby promoting the interaction between virus-infected cells and immune system cells.[30] Reviewed in [20]
Other laboratory studies have shown that the interaction between NDV-infected cancer cells and T cells can be improved if monoclonal antibodies that bind the hemagglutinin-neuraminidase protein on the cancer cells and either the CD3 protein or the CD28 protein on T cells (i.e., bispecific monoclonal antibodies) are also used.[29,38,49,50] Reviewed in [20,44,47] It has been reported that this improved interaction leads to better T cell activation.[29,38] Reviewed in [20,44,47] T cells exposed to NDV-infected human colon cancer cells and bispecific monoclonal antibodies showed not only an increased ability to kill the virus-infected cells but also an ability to inhibit the proliferation of uninfected colon cancer cells.[29,38] Reviewed in [20] On the basis of these and other in vitro findings, it has been proposed that vaccines consisting of NDV-infected cancer cells and bispecific monoclonal antibodies be tested in humans.[20,29,38,44,47]
As noted above, animal cells and animal tumor models have also been used to explore the immunotherapy potential of NDV. ESb, a mouse model of metastatic T-cell lymphoma has been employed in most of this work;[25,28,31,35-37,39,40] Reviewed in [11,20,43-47] however, additional experiments have utilized one or more of the following tumor models: mouse B16 melanoma,[33] mouse Lewis lung carcinoma,[32,35] mouse P815 mastocytoma,[35] mouse Ca 761-P93 mammary carcinoma,[35] and guinea pig L10 hepatocellular carcinoma.[34]
In one study,[35] it was shown that anticancer activity could be induced in mouse macrophages both in vitro and in vivo by infection with NDV strain Ulster. Similar activation of mouse macrophages in vitro was observed after infection with the NDV lytic strain Lasota. In this study, the activated macrophages showed cytotoxic activity toward ESb, P815 mastocytoma, and Ca 761-P93 mammary carcinoma cells in vitro. Other experiments demonstrated that much of the observed anticancer activity could be attributed to the production and release of TNF-alpha by the infected macrophages. In addition, the infected, activated macrophages showed anticancer activity in vivo when they were injected into mice bearing Ca 761-P93 mammary carcinoma or Lewis lung carcinoma tumors.[35] Human macrophages stimulated with NDV Ulster have also been shown to kill various types of human tumor cells.[51]
In another study, Reviewed in [11] intratumoral injection of NDV strain Ulster into growing ESb tumors in immunocompetent mice led to a cessation of tumor growth and an absence of metastases in 42% of treated animals. In the remaining mice, tumor growth and metastatic spread continued at the same rate as in control animals. Reviewed in [11] Additional results from this study indicated that the anticancer effect in the responding animals was due primarily to the activation of T cells directed against a tumor-specific antigen on ESb cells rather than a virus antigen. Reviewed in [11]
Other studies with NDV Ulster and the ESb tumor model support the idea that virus proteins inserted in the plasma membrane of NDV-infected cancer cells may help the immune system recognize tumor-specific antigens better, potentially leading to an increased ability to kill uninfected cancer cells and virus-infected cells.[25,28,31,36,37,39] Reviewed in [11,20,43,45,46] At least four studies [25,28,37,39] Reviewed in [45,46] have shown that T cells isolated from mice that have growing ESb tumors can be activated in vitro by co-culture with NDV-infected ESb cells and that the resulting activated T cells possess an enhanced ability to kill uninfected ESb cells in vitro. In addition, two in vivo studies [31] Reviewed in [11] have shown that mice injected with NDV-infected, irradiated ESb cells are 30 to 250 times more resistant to later injection with proliferating ESb cells than mice that are initially injected with uninfected, irradiated ESb cells. Furthermore, at least two in vivo studies have demonstrated that vaccination of mice with NDV-infected, irradiated ESb cells after surgery to remove a growing ESb primary tumor can prevent the growth of metastatic tumors in approximately 50% of treated animals.[31,36] Reviewed in [11,43,45,46] When the surviving mice were subsequently injected with proliferating ESb cells, they all remained free of cancer, indicating that the NDV/tumor cell vaccine had conferred anticancer immunity.[31,36] Reviewed in [11,45,46] Similar results were obtained from in vivo studies that employed the mouse B16 melanoma model,[33] the mouse Lewis lung carcinoma model,[32] or the guinea pig L10 hepatocellular carcinoma model.[34]
One factor that may influence the effectiveness of NDV/tumor cell vaccines is overall tumor burden. Results obtained with the B16 mouse melanoma model suggest that these vaccines are less effective in individuals with advanced metastatic disease.[33]
References- Lorence RM, Reichard KW, Katubig BB, et al.: Complete regression of human neuroblastoma xenografts in athymic mice after local Newcastle disease virus therapy. J Natl Cancer Inst 86 (16): 1228-33, 1994. [PUBMED Abstract]
- Lorence RM, Katubig BB, Reichard KW, et al.: Complete regression of human fibrosarcoma xenografts after local Newcastle disease virus therapy. Cancer Res 54 (23): 6017-21, 1994. [PUBMED Abstract]
- Reichard KW, Lorence RM, Cascino CJ, et al.: Newcastle disease virus selectively kills human tumor cells. J Surg Res 52 (5): 448-53, 1992. [PUBMED Abstract]
- Bar-Eli N, Giloh H, Schlesinger M, et al.: Preferential cytotoxic effect of Newcastle disease virus on lymphoma cells. J Cancer Res Clin Oncol 122 (7): 409-15, 1996. [PUBMED Abstract]
- Tzadok-David Y, Metzkin-Eizenberg M, Zakay-Rones Z: The effect of a mesogenic and a lentogenic Newcastle disease virus strain on Burkitt lymphoma Daudi cells. J Cancer Res Clin Oncol 121 (3): 169-74, 1995. [PUBMED Abstract]
- Lorence RM, Rood PA, Kelley KW: Newcastle disease virus as an antineoplastic agent: induction of tumor necrosis factor-alpha and augmentation of its cytotoxicity. J Natl Cancer Inst 80 (16): 1305-12, 1988. [PUBMED Abstract]
- Schirrmacher V, Haas C, Bonifer R, et al.: Human tumor cell modification by virus infection: an efficient and safe way to produce cancer vaccine with pleiotropic immune stimulatory properties when using Newcastle disease virus. Gene Ther 6 (1): 63-73, 1999. [PUBMED Abstract]
- Zorn U, Dallmann I, Grosse J, et al.: Induction of cytokines and cytotoxicity against tumor cells by Newcastle disease virus. Cancer Biother 9 (3): 225-35, 1994 Fall. [PUBMED Abstract]
- Cassel WA, Garrett RE: Newcastle disease virus as an antineoplastic agent. Cancer 18 (7): 863-8, 1965.
- Phuangsab A, Lorence RM, Reichard KW, et al.: Newcastle disease virus therapy of human tumor xenografts: antitumor effects of local or systemic administration. Cancer Lett 172 (1): 27-36, 2001. [PUBMED Abstract]
- Schirrmacher V, Ahlert T, Heicappell R, et al.: Successful application of non-oncogenic viruses for antimetastatic cancer immunotherapy. Cancer Rev 5: 19-49, 1986.
- Ahlert T, Schirrmacher V: Isolation of a human melanoma adapted Newcastle disease virus mutant with highly selective replication patterns. Cancer Res 50 (18): 5962-8, 1990. [PUBMED Abstract]
- Kirn DH, McCormick F: Replicating viruses as selective cancer therapeutics. Mol Med Today 2 (12): 519-27, 1996. [PUBMED Abstract]
- Schirrmacher V, Griesbach A, Ahlert T: Antitumor effects of Newcastle Disease Virus in vivo: local versus systemic effects. Int J Oncol 18 (5): 945-52, 2001. [PUBMED Abstract]
- Russell SJ: RNA viruses as virotherapy agents. Cancer Gene Ther 9 (12): 961-6, 2002. [PUBMED Abstract]
- Csatary LK, Moss RW, Beuth J, et al.: Beneficial treatment of patients with advanced cancer using a Newcastle disease virus vaccine (MTH-68/H). Anticancer Res 19 (1B): 635-8, 1999 Jan-Feb. [PUBMED Abstract]
- Csatary LK, Eckhardt S, Bukosza I, et al.: Attenuated veterinary virus vaccine for the treatment of cancer. Cancer Detect Prev 17 (6): 619-27, 1993. [PUBMED Abstract]
- Kenney S, Pagano JS: Viruses as oncolytic agents: a new age for "therapeutic" viruses? J Natl Cancer Inst 86 (16): 1185-6, 1994. [PUBMED Abstract]
- Batliwalla FM, Bateman BA, Serrano D, et al.: A 15-year follow-up of AJCC stage III malignant melanoma patients treated postsurgically with Newcastle disease virus (NDV) oncolysate and determination of alterations in the CD8 T cell repertoire. Mol Med 4 (12): 783-94, 1998. [PUBMED Abstract]
- Schirrmacher V, Ahlert T, Pröbstle T, et al.: Immunization with virus-modified tumor cells. Semin Oncol 25 (6): 677-96, 1998. [PUBMED Abstract]
- Moss RW: Alternative pharmacological and biological treatments for cancer: ten promising approaches. J Naturopathic Med 6 (1): 23-32, 1996.
- Zulkifli MM, Ibrahim R, Ali AM, et al.: Newcastle diseases virus strain V4UPM displayed oncolytic ability against experimental human malignant glioma. Neurol Res 31 (1): 3-10, 2009. [PUBMED Abstract]
- Schneider T, Gerhards R, Kirches E, et al.: Preliminary results of active specific immunization with modified tumor cell vaccine in glioblastoma multiforme. J Neurooncol 53 (1): 39-46, 2001. [PUBMED Abstract]
- Sinkovics JG, Horvath JC: Newcastle disease virus (NDV): brief history of its oncolytic strains. J Clin Virol 16 (1): 1-15, 2000. [PUBMED Abstract]
- Schirrmacher V, Jurianz K, Roth C, et al.: Tumor stimulator cell modification by infection with Newcastle Disease Virus: analysis of effects and mechanism in MLTC-CML cultures. Int J Oncol 14 (2): 205-15, 1999. [PUBMED Abstract]
- Kadish AS, Doyle AT, Steinhauer EH, et al.: Natural cytotoxicity and interferon production in human cancer: deficient natural killer activity and normal interferon production in patients with advanced disease. J Immunol 127 (5): 1817-22, 1981. [PUBMED Abstract]
- Budzynski W, Radzikowski C: Cytotoxic cells in immunodeficient athymic mice. Immunopharmacol Immunotoxicol 16 (3): 319-46, 1994. [PUBMED Abstract]
- Schirrmacher V, Haas C, Bonifer R, et al.: Virus potentiation of tumor vaccine T-cell stimulatory capacity requires cell surface binding but not infection. Clin Cancer Res 3 (7): 1135-48, 1997. [PUBMED Abstract]
- Haas C, Herold-Mende C, Gerhards R, et al.: An effective strategy of human tumor vaccine modification by coupling bispecific costimulatory molecules. Cancer Gene Ther 6 (3): 254-62, 1999 May-Jun. [PUBMED Abstract]
- Haas C, Ertel C, Gerhards R, et al.: Introduction of adhesive and costimulatory immune functions into tumor cells by infection with Newcastle Disease Virus. Int J Oncol 13 (6): 1105-15, 1998. [PUBMED Abstract]
- Heicappell R, Schirrmacher V, von Hoegen P, et al.: Prevention of metastatic spread by postoperative immunotherapy with virally modified autologous tumor cells. I. Parameters for optimal therapeutic effects. Int J Cancer 37 (4): 569-77, 1986. [PUBMED Abstract]
- Shoham J, Hirsch R, Zakay-Rones Z, et al.: Augmentation of tumor cell immunogenicity by viruses--an approach to specific immunotherapy of cancer. Nat Immun Cell Growth Regul 9 (3): 165-72, 1990. [PUBMED Abstract]
- Plaksin D, Porgador A, Vadai E, et al.: Effective anti-metastatic melanoma vaccination with tumor cells transfected with MHC genes and/or infected with Newcastle disease virus (NDV). Int J Cancer 59 (6): 796-801, 1994. [PUBMED Abstract]
- Bier H, Armonat G, Bier J, et al.: Postoperative active-specific immunotherapy of lymph node micrometastasis in a guinea pig tumor model. ORL J Otorhinolaryngol Relat Spec 51 (4): 197-205, 1989. [PUBMED Abstract]
- Schirrmacher V, Bai L, Umansky V, et al.: Newcastle disease virus activates macrophages for anti-tumor activity. Int J Oncol 16 (2): 363-73, 2000. [PUBMED Abstract]
- Schirrmacher V, Heicappell R: Prevention of metastatic spread by postoperative immunotherapy with virally modified autologous tumor cells. II. Establishment of specific systemic anti-tumor immunity. Clin Exp Metastasis 5 (2): 147-56, 1987 Apr-Jun. [PUBMED Abstract]
- von Hoegen P, Zawatzky R, Schirrmacher V: Modification of tumor cells by a low dose of Newcastle disease virus. III. Potentiation of tumor-specific cytolytic T cell activity via induction of interferon-alpha/beta. Cell Immunol 126 (1): 80-90, 1990. [PUBMED Abstract]
- Haas C, Strauss G, Moldenhauer G, et al.: Bispecific antibodies increase T-cell stimulatory capacity in vitro of human autologous virus-modified tumor vaccine. Clin Cancer Res 4 (3): 721-30, 1998. [PUBMED Abstract]
- Von Hoegen P, Weber E, Schirrmacher V: Modification of tumor cells by a low dose of Newcastle disease virus. Augmentation of the tumor-specific T cell response in the absence of an anti-viral response. Eur J Immunol 18 (8): 1159-66, 1988. [PUBMED Abstract]
- Schirrmacher V, Schild HJ, Gückel B, et al.: Tumour-specific CTL response requiring interactions of four different cell types and recognition of MHC class I and class II restricted tumour antigens. Immunol Cell Biol 71 ( Pt 4): 311-26, 1993. [PUBMED Abstract]
- Bai L, Koopmann J, Fiola C, et al.: Dendritic cells pulsed with viral oncolysates potently stimulate autologous T cells from cancer patients. Int J Oncol 21 (4): 685-94, 2002. [PUBMED Abstract]
- Washburn B, Schirrmacher V: Human tumor cell infection by Newcastle Disease Virus leads to upregulation of HLA and cell adhesion molecules and to induction of interferons, chemokines and finally apoptosis. Int J Oncol 21 (1): 85-93, 2002. [PUBMED Abstract]
- Schirrmacher V: Active specific immunotherapy: a new modality of cancer treatment involving the patient's own immune system. Onkologie 16 (5): 290-6, 1993.
- Haas C, Schirrmacher V: Immunogenicity increase of autologous tumor cell vaccines by virus infection and attachment of bispecific antibodies. Cancer Immunol Immunother 43 (3): 190-4, 1996. [PUBMED Abstract]
- Schirrmacher V, von Hoegen P, Heicappell R: Virus modified tumor cell vaccines for active specific immunotherapy of micrometastases: expansion and activation of tumor-specific T cells. Prog Clin Biol Res 288: 391-9, 1989. [PUBMED Abstract]
- Schirrmacher V, von Hoegen P, Heicappell R: Postoperative activation of tumor specific T cells by immunization with virus-modified tumor cells and effects on metastasis. Adv Exp Med Biol 233: 91-6, 1988. [PUBMED Abstract]
- Schirrmacher V, Haas C: Modification of cancer vaccines by virus infection and attachment of bispecific antibodies. In: Walden P, Trefzer U, Sterry W, et al., eds.: Gene Therapy of Cancer. New York, NY: Plenum Press, 1998, pp 251-7.
- Termeer CC, Schirrmacher V, Bröcker EB, et al.: Newcastle disease virus infection induces B7-1/B7-2-independent T-cell costimulatory activity in human melanoma cells. Cancer Gene Ther 7 (2): 316-23, 2000. [PUBMED Abstract]
- Haas C, Lulei M, Fournier P, et al.: A tumor vaccine containing anti-CD3 and anti-CD28 bispecific antibodies triggers strong and durable antitumor activity in human lymphocytes. Int J Cancer 118 (3): 658-67, 2006. [PUBMED Abstract]
- Haas C, Lulei M, Fournier P, et al.: T-cell triggering by CD3- and CD28-binding molecules linked to a human virus-modified tumor cell vaccine. Vaccine 23 (19): 2439-53, 2005. [PUBMED Abstract]
- Washburn B, Weigand MA, Grosse-Wilde A, et al.: TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus. J Immunol 170 (4): 1814-21, 2003. [PUBMED Abstract]


text:
MARCH Central Nervous System Substudy
This study is currently recruiting participants.
Verified May 2013 by Kirby Institute
Kirby Institute
Information provided by (Responsible Party):
Kirby Institute
ClinicalTrials.gov Identifier:
First received: June 27, 2012
Last updated: May 29, 2013
Last verified: May 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
Study Status: | This study is currently recruiting participants. |
Estimated Study Completion Date: | January 2016 |
Estimated Primary Completion Date: | October 2014 (Final data collection date for primary outcome measure) |

subset: commoncrawl


text:
Individual Leadership Development
Leaders' Council offers individual leadership development programs throughout the year that are open to all students. These workshops include topics such as leadership styles, communication styles and personal goal setting skills. Also, if you have a suggestion for an individual leadership development topic, please e-mail Leaders' Council at email@example.com
In addition to individual workshops, Leaders' Council also offers a leadership series, which takes place over the course of several weeks or months. The leadership series, The Leadership Experience (LX), focuses on numerous leadership components that include leadership behaviors, styles and qualities. Due to length,LX allows for more discussion and an in-depth look at different leadership topics. The Leadership Experience, was first offered during the 2008-09 academic year and is now being offered on a permanent basis. For detailed information about the series and when they are offered, please see below.
The Leadership Experience
The Leadership Experience, or LX, is a five session, interactive experience in which ten to fifteen students will discover their personal leadership potential and develop a leadership vision. The first session will begin with a SWOT and DISC analysis and reflection, which will later connect to leadership behaviors, inspirational endeavors and the proponents of effective action plans. Participation will not be based on prior leadership experience; rather, it will aim to attract young or novice students with a propensity for futures in leadership roles.
Participation in LX is open to all students and is based on faculty- student- or self-nomination. Any student interested in participating in LX is encouraged to email Leaders' Council at email@example.com for a self-nomination form.
The Leadership Experience is offered once during each academic semesetr and occurs over a five-week period, one 90-minute session per week. Exact days and times are based on the schedule of each participant and are not determined until all participants are selected.
To view The Leadership Experience flier, please click here.
To learn more about The Leadership Experience and how to participate, please contact Leaders' Council at firstname.lastname@example.com
Past Participant Comments – See what past participants have said about LX.
"I wanted to learn more about myself and others. I learned I need to be more passionate about what I do and find something that motivates me to be better." -Kayla Shadley, 2010
"Being offered an opportunity to further my leadership experience while learning ways to grow as a leader was something not everyone is offered. The expectations I had were met and even more-so – the organization, passion and attitude the Leaders' Council Members had was phenomenal!" -Kathleen Baker, 2010
"LX provided me with a great opportunity to explore, understand and develop my personal leadership skills and gave me a plan to implement my ideas and goals." -Lee Saunders, 2012
Attachment | Size |
LX_Promotional_Flier.pdf | 45.53 KB |


text: Can You Retrieve Your Data After Terminating Your Contract? Consider the following scenarios. Scenario 1: You have a great cloud service provider and have moved all your business data there. One fine morning, you get a notice stating that your provider is going bankrupt and will soon be terminating all contracts. Now, will you get back all your data that is stored on the provider's servers? Scenario 2: You have been using Basecamp for your project management needs, but after two years of usage you find Zoho better suits your needs. Can you easily export all your Basecamp data to


text:
EditBasic Full Name: Ivorie Greene 1 Birth: 25 Nov 1895 1 Death: Jul 1978 1 Residence: Last Residence: South Ozone Park, NY 1
EditOther Social Security: Card Issued: New York 1 Last Payment: Saint Albans, NY 1 Social Security Number: ***-**-5986 1
Looking for more information about Ivorie Greene? Search through millions of records to find out more. Find more records
Anyone can contribute to this page. Please sign in or sign up—it's free. Source: Social Security Death Index Created: 03 Sep 2008 Modified: 07 Oct 2013 Page Views: 213 total (7 this week)


text:
Leather Upper with wicking mesh lining for comfort. Direct injected construction. Removable tri-density PU memory foam insole provides maximum comfort. CSA Grade 1 approved, ESR rated. Composite toe and Flexible fabric LENSI PS4 stadt plate.Wolverine® MultiShox® compression pads on outsole customize shock absorption. Oil and Slip resistant outsole. 200 gms. Thinsulate™ insulation will keep your foot warm and dry.
Average Rating:
(0 reviews)


text:
1 Meetup Group matches "Micro Brewed Beer" near Cincinnati, OH
Cincinnati has a growing craft beer culture that is recognizing not only national craft brews but local breweries as well. More people are starting to explore homebrewing as a hobby and a passion, creating very good beer. Tastings and food pairings are no longer limited to wine and beer lists are rivaling wine lists at many establishments. North of Cincy Sippers is an informal group of folks who want to meet to socialize over a well made drink. Don't like beer, you are still welcome to join! The …
Get an alert email when new Meetup Groups like this start near you.
You'll get advice, help finding members, and tools to make running a Meetup Group easier.


text:
Axis Maps builds custom interactive maps that go beyond cumbersome, traditional GIS or overly simplistic pushpin web maps. We custom-build all of our interactive maps on top of our powerful and flexible technology to match your specific needs.
Axis Maps has built a wide range of map-related projects from traditional print maps to online geovisualization systems, from wall maps to websites. Browse our previous work to see how we've designed solutions for clients of all sizes and contact us to discuss how we can help you.
Indiemapper is a free online application from Axis Maps. It helps you make static, thematic maps from geographic data by bringing the best of traditional cartographic design to internet map-making.
Typographic Maps accurately depict the streets and highways, parks, neighborhoods, coastlines, and physical features of the city using nothing but type. Every single piece of type was manually placed, a process that took hundreds of hours to complete for each map.
Looking for some help on your own mapping project? Use these free resources as a guide as you reproject geodata, choose map colors and fonts, write code, and more.
typebrewer.org | colorbrewer2.org | Code Library


text: Seafood.com News is a premium seafood industry daily service that incorporates the broadest possible news-gathering network to provide up-to-the minute market information and breaking news. The Seafood.com News service provides a comprehensive daily snapshot of vital industry information for seafood producers, sellers, importers, brokers, traders, distributors, buyers, foodservice and retail executives, restaurant owners and chefs. Now with increased coverage of Latin America and Japan. |


text:
Station List Observations Mobile Access Obs via Google Maps Classic Maps Recent Historical DART® Oil & Gas ADCP Obs Search Ship Obs Report Gliders APEX TAO DODS HF Radar OSMC Dial-A-Buoy RSS Feeds Obs Web Widget Email Access Station Status NDBC Maintenance NDBC Platforms Partner Platforms Program Info NDBC on Facebook About NDBC Met/Ocean Moored Buoy C-MAN TAO DART® VOS CSP IOOS® Program IOOS® DAC Publications NDBC DQC Handbook Hurricane Data Plots Mariners Weather Log Observing Handbook No. 1 Science Education NDBC Director FAQ Media Inquiries Contact Us Visitor Information Links |
BuoyCAMs: See recent photos from NDBC NDBC weather buoy 44007 near Portland ME, weather buoy 46054 near Santa Barbara CA, DART station 46410 in the Gulf of Alaska, NDBC weather buoy 46029 near the Oregon/Washington coastline and the following TAO stations: 2N 155W, 5N 155W Station ICAC1 - Search and Rescue Data9410840 - Santa Monica Pier The Station ID prior to 18z, on 1/22/2010 was SMOC1.
Average surface winds - six hour block.
The six-hour averages are calculated as follows:


text:
I am searching for domain name over a week. But all options i have tried bought someone else. And those domain names are not active. They parked somewhere. I am almost out of options. In that case what do you suggest? Which way i should follow?
Whenever I need to think of a new name for a project, I make an Excel list for it. As I think of names, I add them to the list, check to see if the domain is available using GoDaddy, check if someone else is ranking for that name in Gooogle, and then check to make sure I can get the usernames on social networks using NameChk. I then look at all my options, and I usually have something that is available and I'm happy with. Here are some tips to finding a good domain name/business name:
In my opinion - You are better off coming up with a fun and interesting name that has a story behind it and people will remember instead of choosing something descriptive and kind of boring. | |||||||||
It is the same for most people. Finding good domain name that describes you business accurately is difficult task. I can only suggest you to try harder and to brain storm for new ideas. If you have enough money you can try to acquire some domain that is parked, but be prepared for some negotiations and high price. | |||||
If you have at least 200 bucks you could start a naming project on crowdSPRING to let their community help you find an awesome name with a free domain. In my opinion it can be really worth it instead of paying for parked domains. | |||||||||||||
Finding domains that are "dictionary" words but not obscured is next to impossible today. "deals.com" was up for grabs around 1994 or so... ;-) forget about 2011. Instead, make up a word that's catchy or try combining words with short words like "In", "On" and such. (e.g. Groupon.com"). I made up "fooyaz.com" which was available for registration. good luck. | |||
Balaban, what is the business about... I have freely posted many ideas for domain names and others will too. Andy's answer is great. | |||||
A great way for finding an available domain name is by using the tools available on DomainHole. The site is in beta, but you can get in with code DOMAINS. The expired domain search is fantastic - you put in a keyword and it will give back 2 word domains, that include your keyword. The name spinner is also a great tool - gives you suggestions you never even thought of. | ||||
have you tried bustaname ? | |||


text: just an opinion man, i like when people can read my graff. makes me feel good when i hear at a party "did you see that rosie piece off the 190". by all means dude, keep doin what you do. if its gettin you big ups congrats.. i just am givin my opinion.


text:
The Most Important Stranger
Can you believe that someone you never even met yet will impact your life like no other past or present can? That there is a stranger right now out there in the world who will one day be the reason for those idiotic smiles whenever you think of them, your heart suddenly skipping a beat, your breath being taken away, and those sleepless nights when all you want to do is talk to them no matter how tired you are.
Someone that you have never talked to before will one day be the person you will want to talk constantly too. Someone that you may have never seen before will be the person that you will one day want to see constantly just so you can look deep into their eyes. Someone that you have never spent one second with before will one day be the person you will want to spend forever with.
There is a stranger somewhere out there; the most important stranger that you have yet to meet. This stranger will one day be your everything. Your soulmate. The one you will intrust your heart too. The one you that you won't believe you ever lived without. Whether you believe in destiny or coincidence, this most important stranger is the one the you end up falling helplessly in love for.
Submitted by omfgsomeonefinally


text:
Hotels near The Sands End
London > Hotels > Budget Chain Hotel Double + Single Beds: 67% off from £86
Imperial Road, SW6 2GA | 4 minutes walk from The Sands End
You probably won't hear the words value for money that often this close to the ultra chic King's Road but Jurys Inn is a reasonably priced More
London > Hotels > Luxury Chain Hotel Suites: 61% off from £149
Chelsea Harbour, SW10 0XG | 6 minutes walk from The Sands End
Wyndham Grand London Chelsea Harbour is a 5 star luxury all-suite hotel ideally located for both business and leisure travellers. It is set away More
London > Hotels > Mid-Range Chain Hotel Double Rooms: 70% off from £99
Bridges Court Road, SW11 3RP | 8 minutes walk from The Sands End
Hotel Verta by Rhombus is uniquely located at 'London's Vertical Gateway" - The London Heliport, Battersea. The first hotel of its kind " integrated with the More
Location map of The Sands End
Hotels near The Sands End
Customer Service - Speak to a London hotel expert
From United States:
011 44 207 437 4370
8am to 11pm
Toll free:
Free callback service:
We can call you back
Speak to a
London Hotel Expert
Top rated hotels near The Sands End
Previous customers have given the highest customer satisfaction score to these two hotels near to The Sands End:
Nearest hotels to The Sands End
There are 4 recommended places to stay within a 15 minutes walk from The Sands End:
Jurys Inn Chelsea Hotel London ( 4 minutes)
Wyndham Grand London Chelsea Harbour ( 6 minutes)
Hotel Verta by Rhombus ( 8 minutes)
Millennium & Copthorne Hotels at Chelsea FC ( 12 minutes)
Connect live to hotels' reservation system
Lowest rates available anywhere
Bookings made instantly with the hotel
Receive hotel's own reservation number
Pay the hotel directly
Our service is 100% FREE
LondonTown.com exclusive free extras
Hotel experts with 15 years experience
More about our customer service team


text:
Wagner & Me | Movie review
Actor Stephen Fry interrogates his fondness for the composer.
With an enthusiasm as genuine as it is infectious, actor Stephen Fry investigates his fondness for the imperial 19th-century opera of Richard Wagner. Wagner & Me functions as a primer on the composer's music as well as the historical context of his career, its relationship to Nazi Germany and its hold on Fry's own life. The film is a curious hybrid held together by Fry himself; the raconteur proves a knowledgeable and gregarious tour guide, delivering historical time lines and personal anecdotes as he travels to key locales (Germany, Switzerland, Russia). Whether talking with Wagner biographers, sitting in on rehearsals for stagings of the Ring Cycle, or getting the chance to play the famous "Tristan chord" on Wagner's own piano, Fry details his enthusiasm for the composer's technically and emotionally complex art with a fan's passion and a scholar's insight.
Wagner & Me doesn't sell its subject's compositions short; more impressive, however, is Fry's candid confrontation of the profound disrepute bestowed on Wagner by Hitler's affinity for his work—a legacy that Fry, a Jew deeply troubled by this unavoidable fact, likens to a beautiful tapestry besmirched by an irredeemable stain. In honestly questioning whether his Wagner fanboyishness is a betrayal of his Jewishness, Fry uses his film as a means not just of celebration but of thorny cultural-historical analysis.


text:
'eTown' Live Radio Show Taping
Wednesday, June 9, 7–9PM at Flynn MainStage in Burlington. $23.25-28.50.
Contact Info:
- 802-863-5966
- Event Website
Seven Days Says:
Nick and Helen Forster host a weekly broadcast featuring conversation with environmental and social innovators, and tunes by Steve Earle, Allison Moorer and Anaïs Mitchell.


text:
Scotts Miracle-Gro Garden Feeder - 100410
$10.99The New Miracle-Gro Garden Feeder provides a better experience with improved features and performance. Features include a new easy-to-grip handle, trigger with lock for one-handed control, and three spray patterns: shower, jet and stream.
Learn More -
Scotts Miracle-Gro LiquaFeed Refill Pack (4 bottles) - 1004322
$12.99Ready-to-use refill bottles are for use with the Miracle-Gro LiquaFeed Garden Feeder.
Learn More -
Scotts Miracle-Gro LiquaFeed Starter Kit - 101411
$10.99Product Features- Patented feeder and ready-to-use refill bottle system takes the guesswork out of feeding: No mixing, no measuring, no mess!
- No more guessing when the plant food is gone--when the bottle empties, feeding is done. Automatically applies plant food at an even rate--no worry of over- or under-feeding.
- Feeder easily switches between feeding and water-only options.
- Three spray patterns (shower, jet and flat)
Garden Tone 20 Lb 3-4-4 GT20
$14.99Garden-tone is an all natural plant food formulated specifically for vegetable gardens. It is safe, long lasting, and will provide the nutrients necessary for vigorous and productive plants. Garden-tone's all natural formula contains Bio-tone®, our patented blend of beneficial microbes. Bio-tone biologically enhances our natural plant food to ensure superior plant growth.
Learn More -
Espoma Holly Tone Fertilizer 20lb
$14.99New PlantsDig a hole twice as wide and the same depth as the root ball so that roots can spread naturally. Remove 1/3 of the soil and replace it with compost, peat moss or humus. Mix 1 cup of Holly-tone into amended soil. Place the plant in the hole so that it sits at the same depth it was previously growing (use soil mark on the trunk as a guide). Fill the hole halfway with amended soil. Pack the soil firmly, soak it with water, and allow it to settle. Finish filling hole leaving the top two inches loose for easy absorption of water. Make slight depression around the plant to help hold water. Add mulch to help conserve water, slow down evaporation, and control weeds. Keep well watered until plant is established.
Established PlantsFeed acid-loving plants twice yearly - Spring and Fall. Use half the recommended rate in the Fall application. If the area to be fed is mulched, it is preferable to remove the mulch, feed and then restore the mulch on top of the plant food. If this is not possible, double all recommended feeding rates.
Learn More -
Preen Weed Preventer 5.625 lb
$10.93- Covers 960 Square Feet.
- Prevents weeds when used as directed.
- Keeps out virtually all weeds around flowers, shrubs, ornamentals, and certain vegetables.
Scotts Super Turf Builder 16lb 30-3-3
$11.91Product Features- Contains iron
- Formed into concentrated nuggets for fast, deep greening that lasts up to 2 full months.
- Use anytime and no need to water.
- Analysis: 30-3-3.
In stock
Fertilizer 12-12-12 40 Lb
$11.99Club Green® All purpose Fertilixer is easy to use and produces vibrant growth from tender to beginnings up through a sturdy, resilient turf. We also recommend Club Green All Purpose Fertilizer for Vegetables, flowers, fruit, nut and shade trees and hardy evergreens and shrubs. For best results, use according to the following directions and water thoroughly after each application.
Learn More -
DSM Ammonium Sulfate 51lb Bag
$11.99Ammonium sulfate is used as an agricultural spray adjuvant for water soluble insecticides, herbicides, and fungicides. In the solution it functions to bind iron and calcium cations that are present in both well water and plant cells. It is particularly effective as an adjuvant for 2,4-D (amine), glyphosate, and glufosinate herbicides.
Research with various crops and these herbicides has shown that weed kill has been increased when ammonium sulfate is used as an additive to the tank mix.
Recommendations for use & mixing rates.
Only a small amount is added to the herbicide (8-20 lbs per 100 gallon of water). Agitate the tank water while slowly adding the product. Allow enough time for complete dissolution before adding additional adjuvants or herbicides to the tank.
- Ammonium Sulfate: 99.5%
- Water: 0.5%
- 40 bags per skid


text:
Whirling Dervishes of Rumi
The Sufi group, The Whirling Dervishes, have traveled from their native Turkey and are in Charleston for one night only, for a performance of live music and spiritual dance. The performance sybolizes the values held most important to this order, including the universal values of love and service. Charleston Music Hall, 37 John St. Wednesday, 7pm. $25; $15 student. (843)801-1483, www.charlestonmusichall.com
March 13, 2013 - 7:00pm - 9:00pm
Charleston Music Hall, 37 John St.


text:
Program Mission Discovery Club's mission is to provide out-of-school time child care in a safe, fun, caring environment that supports children's learning and development.
Children participate in a variety of academic enrichment, recreational and cultural activities that informally support learning and social development. Life and social skills, such as cooperation, teamwork, and problem solving are fostered in a caring and accepting environment. Additionally, Discovery Club staff connect with school-day teachers to better support children's learning, including scheduled homework times.
Well trained staff enjoy, respect and build relationships with children and families in Discovery Club. Many work at Discovery Club for several years, building strong bonds with children. All staff must meet high qualifications and receive frequent, on-going training.
Discovery Club is a non-profit, funded by parent fees, and administered by the Community Education Department of Saint Paul Public Schools. What are Discovery club Hubs? (click image to enlarge) Any student enrolled at a non-DC school within the same district area may apply to hub sites.
Questions? Contact our administrative office at: 1780 7th Street West Saint Paul, 55116 651-632-3793 email@example.com
Adams *Battle Creek (area B hub) Crossroads Expo Four Seasons (area F hub) *Hamline (area E hub) Highland Park Horace Mann JJ Hill L'Etoile du Nord *Mississippi (area C hub) Nokomis (area A hub) Randolph Heights *Riverview at Roosevelt (area D hub) Rondo St. Anthony Park *new site in 2013-14
Looking for Building Permits? Click here


text:
The Policy Advisory Committee generally meets on the fourth Tuesday of the month to discuss policy issues of interest to SVBC and advise the SVBC board and staff on positions. Members of the committee are appointed; meetings are open to current SVBC members.
Tuesday, October 29 - 6:00PM to 8:00PM
SVBC Office
1922 The Alameda
San Jose, CA
United States


text:
Find the Perfect Gift
Please select an age range or price range.
Select an Age Range Birth-12 Months 12-24 Months 2 Years 3 & 4 Years 5-7 Years 8-11 Years 12-14 Years Big Kids
Select a Price Range under $10 $10 - $20 $20 - $30 $30 - $40 $40 - $50 $50 - $75 $75 - $100 $100 and up
Both Girl Boy
Buy 1 Get 1 40% Off
Sale $39.99
Easy Bake Ultimate Oven
Buy 1 Get 1 50% Off
ALL Crayola Arts & Crafts
selected Frozen Dolls & Play Sets
NERF Blasters
Clearance Blast!
Up to 70% off in our OnlineClearance Store
Stocking Stuffers
Thousands of Toys $10 or less!
20% Off
Transformers Construct Bots
Sale $12.99
Shimmer n Sparkle Cra-Z-Loom Rubber Band Bracelet Maker
Sale $224.99 ea.
Power Wheels 12-volt Corvette
ALL Mega Bloks Building Sets (excludes diecast)
$21.99 ea.
Monster High Boolittle Doll or Class Play Set
Save $20
Tabeo e2 Tablet
ALL VTech Toys
25% Off
ALL Disney Planes Diecast, Play Sets & R/C
All Video Games, Video Game Accessories, Movies & CDs
Usually leaves warehouse in 1 - 2 full bus. days. Details
Gift wrap is available for this item. (Details)
Product is available for shipping internationally. (Details)
The Babies'R'Us Reusables Bowls with Lids are just what every parent needs to cure those little tummy growls on the go! Pack up snacks in these colorful containers without worrying about spills; the lids seal tightly to keep food fresh and prevent leaks. The Babies R Us Reusables Bowls with Lids 7 Pack - 8 oz features:
"R"Web#: 034395
Manufacturer #: 3922155
Product Weight:0.5 pounds
Product Dimensions (in inches):5.0 x 4.5 x 4.3
Shipping Info:
Average Customer Rating:
(based on 14 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Best Uses
Most Helpful Positive Review
Reusable Bowls
These bowls are awesome. I Make a lot of my sons food and puree it at home. I use these bowls to store the puree in. They are great: they stack well, clean...Read complete review
These bowls are awesome. I Make a lot of my sons food and puree it at home. I use these bowls to store the puree in. They are great: they stack well, clean easily, hold a lot, and haven't leaked yet. It also helps that they are cheaper than the national brand. Also, bought the cups....love those as well. I have nothing negative to say.
Most Helpful Critical Review
Not good for storage
If you just need the bowl, then you are fine. But if you want to use the lid, don't even buy this product. If you get the lid on, good job... ...Read complete review
If you just need the bowl, then you are fine. But if you want to use the lid, don't even buy this product. If you get the lid on, good job... But then it will pop off or it leaks.
Reviewed by 14 customers
Sort by
Displaying reviews 1-10
Back to top
Previous | Next »
Reuseable bowls are great
By Mom of 2
from Phoenix, az
About Me Parent
Comments about Babies R Us 1011187 Babies R Us Reusables Bowls with Lids 7 Pack - 8 oz:
Love these bowls. Great to heat in the microwave. Easy storage
Comment on this review
lid does not stay in place
By mommy of a 3year
from queens ny
See all my reviews
okay as feeding bowl but not for storage and transporting food because the lid does not stay in place.
I would give this as a gift!
By Michell
from Canton, MI
Great for feeding on the go and snacks.
Great for travel -- meals or snacks
By Mel C
from Wisconsin
We are always on the go, and are great for bringing along snacks or finger foods.
A great Product!
By On the go mom
from Norfolk,VA
This product is great for lunch boxes, in the car and on the airplane! keeps snacks fresh and easy to pack. The lids stay tight and easy to open when needed.
By ari'sma
from pennsylvania
Fits my needs for feeding my 4 month old. Easy to mix cereal in. So far so good in the dishwasher (no melting or anything).
By Shannon
from Auburndale, FL
About Me Parent, Thrifty
Reusable bowls with lids
By First time mommy
from Washington, PA
About Me Education Oriented, Educator, Parent
I use the product for my son's rice cereal currently. I really like the size of the bowls and that they are easy to clean. I was a little upset with the product when I opened it and 2 of the lids were cracked and broken.
Great for early feeders or snack foods
By Momma
from Wilmington, Delaware
These bowls are great for early stages of baby food. They're a good size. Also good for my toddler for snacks.
Great Deal for the Price
By Stay at Home Mommy of 2
from Hermitage, Pa
Love the colors and style of the bowls. Work great as snack bowls for my three year old. Definitely better quality than the name brand version and much for wallet friendly.
Product availablitiy and pickup options will be displayed for this store. You can change this store anytime using the Store Locator or My Store Link.
© 2013 Geoffrey, LLC. All Rights Reserved. Use of this site signifies your acceptance of Toys''R''Us Website Terms and Conditions and Privacy Policy.


text:
I Did It... - I ended it. I didn't hear from him for several days, then he calls me yesterday as if nothing is wrong. I just realized that for 15 months, this has been entirely on HIS TERMS and that's not acceptable to me anymore. With Christmas and New Years coming, who will he...
11 Responses
Dec 21, 2011
Women And Men - I wanted to share some basic thoughts I have because I feel that men are suffering as much as we are in some form.
One thing that we should realize is that human emotions are real even for men. But they ARE able to compartmentalize. They just are. And we have to...
5 Responses
Jun 3
I Will Never Be Again - He said he loved me for about a month, and that he loved me more than he loved her, till I went crazy jealous because he would not leave her. He admitted he didn't love me anymore after that, but that he still cared. I was still in love or thought I was...
4 Responses
Jul 9
Please Help - It was a long-distance, emotional affair. I met him summer 2012 while on vacation. I was only there for a couple of weeks but we continued to talk to each other via phone and Skype for the next five months. He also had a long-distance marriage because his wife was...
1 Response
Oct 19
Again & Again.. - I know I've written two other stories about you. Of the start of it all and the last time we talked which was the begining of summer where we had our closure. That was it. I thought things were done. I got a new phone, changed my number.. didn't bother...
Nov 3
Today Is My Birthday. - Today is October 1, 2013, my birthday. For the weeks leading up to today, I wondered if you would call, or text me to wish me a happy birthday. It's nearly 8 pm and you haven't. I'm fairly sure you won't. We broke up over a month ago, on August 30...
4 Responses
Oct 1
Bound To You - It's hard to breathe. I wake up every morning feeling lost, numb and confused until concsiouness creeps in and reminds me that we are over....I remember that you are no longer in my life and then a sense of dread washes over me: I must get through this entire day...
3 Responses
Sep 2
Same Ole BS But A Different Day - It started at work. I was in an unhappy engagement and my ex MM was gorgeous and charming. He never talked about himself, I only told him about me. He didn't wear a ring.I asked for his number. I knew it would lead to more. We began meeting up...
2 Responses
May 22
Hope This Is Close To My Last OW Story - So, the ***** marine alpha male MM that I was hot and heavy with this time last year has been relentlessly texting me lately. My last story was about me finally telling him to "delete my number". Man, that felt so stinkin' good.
Well, he...
1 Response
Oct 18
I Got Involved With A Seperated /Getting Divorced Woman - I was having a drinking problem 10 +years ago and met this girl in AA who's family wanted her to go to
it all ended up the same way as a girl with a married man getting divorced
feels great and caring then your left alone...
1 Response
Sep 23
Update To My Love In Blind Post - So if you read my other post you would know I got into a relationship with a man that had someone. You would also know I didn't know till I had fell for him that he had someone else he would lie and just deny it....so my update is he wasn't lying...
Oct 7
And It Hurts - I've been that other woman on more than one occasion and it sucks. I realized that it's not fair to anyone and we all suffer from it. I don't know why I did it but deep down I knew that nothing would become of it. Still it hurt, and as much as I blamed him, I too...
15 Responses
Oct 28, 2007
She Was The Woman And I Happened To Be The Other... - the story runs behind a whole lot of memories of complete 3 years which i have been cherishing for the last 05 years, since she turned out to be the woman, and i happened to be the other...
He was my...
Oct 15
I Dare You - You called me today. I was surprise and the sound of your voice took me back to see what I lost and was never mine. I found your daughter's sippy cup in my car today. I was doing well until I saw that. God I am so angry with you. I was so stupid. I could handle this...
4 Responses
Aug 21
I Was the Other Woman - and it was the worst decision of my life. not only did i betray myself, but i betrayed my best friend in the whole world - it was her boyfriend. there's not a day i don't look back and hate myself for what i did. i ruined so much through my inability to...
10 Responses
Mar 21, 2008
I Was Young! - Just lately I have been looking and sorting stuff out at home, de-cluttering. Anyhow I came across some old diarys and decided to look and read them....
I realize now the guy I dated when I was 17 was using me...
I was 17 at the time and he was 27. My mom had...
2 Responses
Nov 13
Irristable Coworker - I am a professional well educated person. In my career I help others. I became involved with a married coworker and I myself am married. We both have children. He called me while I was hospitalized and stated he had been thinking about this for a long time...
5 Responses
Aug 17, 2009
The One The Works Out - Sometimes it works out. I'm a work in progress, at least. :)
For this story, my man's name is Bob. We've been together for a year and a half.
I never, ever, ever thought that I would fall in love with a married man. I have lived a "good" life from an...
Sep 16
I Feel So Weak - I feel so weak right now. All I want to do is reach out to you and run back into your arms. I would give anything to hear your voice. We haven't spoken in 5 days and it feels like we've been apart for a lifetime. I'm at work and I can't focus. I'm fighting...
1 Response
Sep 5
All Good Things Must Come To An End.... - I finally gave in to my co-worker after months of flirting, and his persistent pursuit. After we decided to "go-ahead", he changed and contact became less frequent. Our converations were all direct to the point about when and where we...
4 Responses
Oct 7
Love...........Is - It is an easy thing to hate
but love
is an entirely different thing
to completely
l e t g o
and give yourself up.
........to let someone explore
the depths of your
(which were so carefully hidden away)
to allow someone the
p o w e r
to destroy you
Jun 18
Young And Caught Under His Spell - Never in my life have I been in love. I'm to young for that. I am a good person, I never really get into any trouble. I am helpful, loving and kind. I am a respectful young girl with a promising future. Or I was. I went to the beach this summer...
32 Responses
Oct 3
I Ended It - Just now i ended it with my mm. I hope it stays ended. I cant cope with the constant explosion of emotions anymore. Its a game for the mm. A drug for the other woman. I know this now. Before the current mm i was always in control, nevet wanted or expected more. But...
6 Responses
Oct 5, 2012
I Want To Know? - I never thought of myself as the other woman until recently, maybe as I am married too. I had lots of major traumas in my life and a husband of many years who does not emotionally connect with me and could not support me through the traumas. I fell in love with...
16 Responses
Oct 26
4 Weeks Today - Exactly four weeks ago today we broke up. We talked, we hugged, I cried. You stood at the door for a long time, almost frozen, like you wanted to say something or do something. I stood in the living room, watching you, and cried. I knew this was it. I knew that...
2 Responses
Sep 27
Yesterday - Yesterday, I was clever and tried to change the world.....today I am wise and decided to change myself.
2 Responses
Jun 2
2008 - This was the year that my life truly started I believe. I was working as a private photographer and was hired by a woman to photograph her family's Christmas party.
When I arrived, she was very very bitchy and expected me to do more then what she'd hired me for. Shortly...
1 Response
Nov 24
Pullupgirl Has A New ID - Watch out for afica24white it's her new tag.
8 Responses
May 31
What If Your Soul Mate Is Taken? - Parts of our relationship were completely cliche. We knew each other in high school, though we never dated back then. We lived about 1000 miles apart and both traveled frequently for work. We reconnected on Facebook and I was prepared for a...
2 Responses
Sep 15
A Mistimed Lover... - OK, I admit it to myself. He said I wasn't but I knew she'd keep him somehow, and surprise, she has. I know he tried to break away, but in the end, I lost.
Goodbye, My King...I must go for good now. To anyone reading who knows the story here, if you...
11 Responses
Jul 18, 2009
Being The Other Woman - I've been reading and reading and it sadly doesn't surprise me how judgmental some people can be, but on the flip side it doesn't surprise me to see kind words and encouragement. Being the other woman is probably the hardest life experience I've ever...
12 Responses
Jul 4
Couldn't Take It Anymore... - We met online but had so many connections it just seemed natural that our friendship developed into a relationship. I knew from the very beginning that he had a girlfriend but he always swore he was miserable with her and was going to break up with...
8 Responses
Feb 10, 2012
Time Heals All....... - It has been said that time heals all wounds. But I think the wounds remain. In time, the mind, protecting it's sanity, covers them with scar tissue and it allows you to move on and live. But they are never forgotten. They however, make you stronger...
4 Responses
Jun 20
Blind To Love - So I was the woman that thought othe women that messed with men that had girlfriends or wives were dumb and insecure wanted someone to depend on. Intel it happened to me. I'm young and go for the older men. But any who I met a guy that wasn't Prince Charming but...
4 Responses
Sep 2
Value, Love & Respect Yourself...Know Your Worth - "How many of you reading this has had a lover or significant other crawl back to them after a few months or even a year, full of apologies or even snot bubbles and tears? Not to check your ego, but most those people don't...
1 Response
Oct 30
Only Once But So Mad - Just some background, I've always said I'd never, ever be 'the other woman'.
So, about a year ago now, I met this guy named Jacie. I was fresh out of a relationship and not looking for anything serious. He propositioned me online. I didn't even know what...
1 Response
Oct 19
I Know - I know that text message that just came in isn't from you. I know when my phone rings next time, it won't be you on the other end. I know that the motorcycle that just rolled down my street isn't you. You're not coming to tell me that you can't live without me...
5 Responses
Sep 5
The Sound Of Trumpets! (Somewhere Off In The Distance) - Well, I ended it with MM back in Feb 2013 and I was heartbroken for a while, then mad, then ambivalent. Now I am pretty sure I am on the doorstep of "I don't give a "puck" about him anymore! After months of no contact, he...
6 Responses
Aug 22
Today Is Your Birthday. - Today is your birthday….and just over 3 weeks since we broke up. My goodness it feels like forever. How is it that a few weeks is blip on the screen of life, and yet since you left my life, these last few weeks seem like an eternity? I've been living...
1 Response
Sep 22
How Do You Get Closure And Walk Away For Good? - My recent relationship just came to a screeching end last week. All he did was lie to me and I made him tell his wife last week.
I don't know how to get over this. How do you move on and not contact him anymore?
8 Responses
Oct 2, 2012
I Was So Stupid...But He Was So Passionate - I fell for the "I'm unhappy, I'm leaving" bit. And in my heart I knew better... But my body didnt care. It was so hot when we were together!! No one has ever kissed me or touched me the way he did. Lust is a powerful thing.
4 Responses
Oct 16
Yes I Was - Yes it is true. I was once the other woman. This was a few years ago. I made a promise to myself to never be again. It is one of the worse feelings to have when you are not completely whole with a person.
He was a married man. He always said that he loved me. I...
2 Responses
May 31
He Died In My Arms - He Died In My Arms.
Posted February 10th, 2012 at 9:12AM
We met a little over a year ago...instant attraction both physical and emotional. Our bond grew with each passing day talking for hours when possible, sharing what was happening in each others lives...
10 Responses
Feb 10, 2012
I Fell Into The Trap Of A Married Man - There is no good thing about an affair, unless you are not in love with the person. You can easily rid yourself of them. Jealousy, pain and loneliness is not worth ruining a marriage. If I could go back and change it, I definitely would...
3 Responses
Nov 18, 2011
He was my boss. Well one of them. I knew there was something there on his end within minutes of meeting him. We got to know each other during breaks..and he would complain about how horrible his wife was and about how much he wasn't into her. We got along really well and one...
1 Response
1 day ago
I Leave You To Be Married - I wonder, as I am reading an email from MM and he is telling me that he just wants me. How does he still come up with those words?? We haven't seen each other for awhile yet he still feels the need. It's not as if we were ever in a place where I...
3 Responses
May 28
Its Too Good To Be True. - I met a guy at the tutoring center at my school. We chatted and worked on math together. After, he gave me his number and told me to text him if I ever wanted to study with him. So I did. We got to know each other better and I started to have feelings...
2 Responses
Nov 12
Putting The Pieces Back Together - I gave my love to him and he tore my heart into a 1,000 piece puzzle. I was nothing more than a joke to him.
I can't sleep, food has become my enemy and these tears, these tears have become my miserable new friend. I have fallen apart; my...
4 Responses
Oct 11
I Was Their Nanny - Please don't judge me, I already know I did wrong. I was 19 when I went to England to work as a nanny for a loving family in a small village. He was 39, his wife was 42. She was lovely, had a great sense of humour and just made anyone love her. She was a make...
12 Responses
Dec 23, 2012
My Eyes Are Beginning To See Some Light At The End Of The Tunnel - Spot on babies!! This sounds familiar to ME! Worth the read:
Welp, it's been almost a week since I last spoke to my MM. I...
1 Response
Oct 4
Our Story - I no longer live in his heart....so there is no need to wake in his world. Our story is complete. The pages are written. It is filled with love, heartache and triumph, happiness, erotic sensuality and undying emotions. It is our love story. You and me. Our...
5 Responses
Jun 26
Grieving - I am not an organized woman... I never have been...
I'm wild, passionate, witty, a risk taker even, but my thoughts race inside of my mind. At night I struggle to sleep... Honestly, I'm not even that grammatically correct I just enjoy writing what I do know.
I've seen...
2 Responses
Sep 15
I Didnt Know I Was The Other Woman For 2 Years DO NOT TRUST A MARRIED MAN! R Johnston
I knew this man who was married and I had a short affair with him. I left. I knew it was wrong. I started a new relationship with a single man and was moving on. The married man...
1 Response
Dec 4
I WAS the other woman. Up until about a month ago, he broke it off. Im respectful of his decision, whatever it may be. I have handled this great. Very little tears, and little thoughts. Of course I do think of him alot, but I try not to think of the things that would make me cry...
4 Responses
Dec 3
I Am Not The Other Woman - I am the betrayed wife (now ex-wife). I am asking for your input and knowledge. I tend to believe that other women are all *one size fits all* when it comes to their personalities or character. At least I believed that before I spoke with one last...
8 Responses
Nov 21
Being The Other Woman - I never had much opinion when it came to infidelity but that was at a time when I never had to think about it because it wasn't something I needed to think about. I was a teenager, so in love with my first boyfriend. I loved him and he loved me, that's all...
2 Responses
Nov 19
So Called Other Woman - I don't know if I can say I am the "other woman", reading every ones stories, I have to say I am probably so much less, we both are married (miserably) and found sexual satisfaction with each other, but from the start we made it clear that it was to be no...
4 Responses
Nov 22
I Am The Other Woman - I love this Married man and he has two adorable kids and a beautiful wife. I worry about what will happen to his kids if anything ever happens, I don't want him to leave his wife but what if he does anyways? Him and his wife have agreed they only got...
Nov 17
It started out as a one night stand.
Now let me give you a little background on me. I was the girl who previously frowned upon one night stands. I always said that I would NEVER do such a thing, as people who invoked in one night stands either had low self esteem or just sex...
1 Response
1 day ago
I've read a lot of your stories ladies and some spoke to me and some didn't. Yet I feel compelled to write my own tho not very different than some here, I am just happy I found a group like this. Like many others I never really believed cheating was right until I fell into it.
2 Responses
Nov 27


text:
Helloooooo Johnny Jolly! There may be a fight on the first snap! I hope he continues to get his stamina back, he's looked great, but more importantly, plays with an infectious attitude. Combine him w Jones, Daniels, and the others, you have the makings of a nice rotation.
The Journal Sentinel's team of Packers beat writers provide the latest news, notes and analysis
Datone Jones injury doesn't appear to be too serious
Green Bay - There's no word yet on how long rookie DE Datone Jones will be sidelined, but early indications are that his sprained left ankle wasn't severe.
Jones initially injured the ankle on his first play against Arizona and did not play another down. He sat out all of last week and returned to practice on Monday.
During a team drill midway through practice, he rolled the ankle again and limped badly off the field. After trying to walk it off, he went into the Don Hutson Center to have ice applied to it.
A source said that the injury wasn't serious and it's too early to tell if he won't play Friday against Seattle. The big concern is whether it turns into something worse over the next day or so or remains troublesome all through the season.
Jones missed all of the 2010 season at UCLA with a broken foot, but that was on his right side. He started all 25 games of his junior and senior seasons.
Early in camp, Jones looked like he was going to be an instant contributor. He was terrific in the 1-on-1 pass rush drills and showed some natural pass rush ability in the intrasquad scrimmage.
The ankle injury, however, has made it so he has one play of preseason action under his belt. If he doesn't play against the Seahawks, it would leave him with only one option to get playing time before the regular season.
"It's hard for any young guy if he's not on the practice field," defensive coordinator Dom Capers said. "We've been through that here before. You remember Clay's (Matthews) rookie year and B.J.'s (Raji) rookie year; Clay had the hamstring, B.J. sprained his ankle in the last preseason game.
"We've had Datone for one play in the preseason. That's just the way it is. Once he's back and ready to go, we're going to have to really put him on a crash course."
The one thing Capers has going for him is that the depth on the defensive line is the best he's had since he arrived here. He needs more pass rush from somebody, but with Johnny Jolly emerging as someone who could help, Mike Daniels healthy and Mike Neal rotating from outside linebacker to defensive lineman, he has some options upfront.
But Jones was drafted with expectations he could help as a pass rusher and if the injury lingers, it could put a damper on his rookie season.
- You can log in to this system either through Facebook or using your JSOnline public profile. JSOnline public profile. Please note that your public profile login will be different than your JS Everywhere login.
- You can personalize your public profile with a photo. You can also use that profile to sign up for email newsletters and alerts.
- While we strive for a lively and vigorous debate of the issues, we do not tolerate name calling, foul language or other inappropriate behavior. Please see our discussion guidelines and terms of use for more information.
- While we do our best to moderate comments, we do not screen comments before they are posted. If you see a comment that violates our guidelines, please use the "Report Abuse" link to notify us of the issue.
- We reserve the right to close commenting on specific stories.
Man, I bet they shut him down for the preseason. They need him healthy.
Helloooooo Johnny Jolly! There may be a fight on the first snap! I hope he continues to get his stamina back, he's looked great, but more importantly, plays with an infectious attitude. Combine him w Jones, Daniels, and the others, you have the makings of a nice rotation.-
I agree, let it get 100% healthy. On the one play we what he can do and it looks good. . Lets make sure he can make the games when it counts.
That was we saw. Yikes.
Jolly was great against the Rams. There was a lot about the tipped pass and his INT - well deserved. But, he also had a bunch of disruptive plays both run and pass. He's on a mission.
Spot on, Lept.
One of writers said he only played 15 snaps? He had at least five "plays" that I can remember. Amazing game for him. -
I'd be okay with getting 15 snaps per game out of Jolly, particularly if the quality stays high. I agree with your original post too - I suspect they're using preseason to help him get in shape. it's hard to judge on those really big guys but he looked heavy to me at St. Louis.
I'd sure like to see Jones on the field this weekend but the thing about sprained ankles (or almost any injury) is come back even slightly too early, live to regret it.
Would like to see Jones in there with Clay and Perry causing havoc and would allow BJ, Pickett Jolly and Daniels more one on one match ups to beat lets get this thing going !!
Everybody benefits with more pass rushers ready to come. Don't forget Neal as a stand up rusher from the LB position as well.
Neal is a wash...forget him...
What is the percentage of 1st round picks that have (barely) played due to injury. I know the Packers' percentage is around 90% based on the last 5 years or so.... what about the rest of the league?
that would be interesting to see, I bet the Packers are near the top in the bad luck department.
BR-- I've been trying to get some form of this question addressed during JSOnline chats or perhaps as an article but so far nada. But here's a good link with stats that show the Packers as the NFL's most beat-up team during 2012:
Notice the least-dinged-up team: The 49ers, by far.-
Injuries have a lot to do with success but deep rosters and the ability to find free agents available in mid season for replacements also helps. In 96 we lost two key. cogs in Chumura and Brooks. In 2010 we lost............( I am limited in the amount of characters here so I can't list them all) but we still got it done.
Packers were decimated by injuries in 2010 (XLV). Some of them helped:
Barnett, Burnett, III, Childress, Jones Zombo, Neal, Tauscher, Grant, [Jolly], al Harriss, Finley, (SB: Driver, Woodson), AR missed a game
link mentioned: http://www.dallasnews.com/sports/databases/20130109-nfl-team-by-team-injuries-can-cowboys-use-health-as-an-excuse.ece
I think they could use owner/GM Jerry Jones as an excuse, it is probably the real reason they haven't gone anywhere. They do have great cheer leaders though.
Cheerleaders there are over-hyped, too.
Over hyped and over exposed.
As we already know the injury is not that serious and I see Jones will be a quick study so I am not concerned if he plays at all during the preseason... Our DL I see thus far improved....
Has anyone noticed how well the defense played last year in Houston when Raji was out, especially against the run? What about the year that Raji was a rook and Pickett was primarily at the Nose? I believe we were #1 against the run at 83.3 yds/gm....
This year, I believe the Packers would be smart to play Pickett primarily at NT and rotate him with Raji regularly.... Raji can slide to DE or take a rest when Pickett is at NT.... We can prolong Pickett's career if we start to use him strictly as a backup NT or occasionally at DE on obvious rushing downs.... Not to mention helping keep Raji fresh throughout the season....
Overall we need Jones but technically we should be fine without him for a little bit more... I think Jones will be back and ready to roll soon than later...
I'm not sure how much of a pass rush veteran DL Ryan Pickett has left in him. At this point of his career, I believe he is much better suited to be a run stuffing NT / DE rather than someone who can be counted on to get upfield and make plays behind the line of scrimmage.
Somebody should teach these guys how to walk and chew bazooka joe at the same time.
His initial injury was caused by a leg whip trip.
DO NOT play Jones this Friday.
Let him heal and play the 4th game of the preseason--if that. This is obviously a recurring theme, and we must get him 100% healed so he doesn't keep aggravating it.-
He needs to stay off the ankle until season start. That would be barely enough time for ankle sprain to heal. He's not going to be 100% even then.
See? He is following in the path of Clay and BJ. Excellent.
LOL I hope you are correct. But I think you would agree that NT B. J. Raji performed only okay a season ago and he needs to really step it up this season. Thoughts? Comments?
My hope is that Jolly makes all of them better...and Jones, too, eventually. Does that mean that Raji deserves a big pay-day? Maybe not. Maybe it means that another big guy could do as well for less money.
But who knows how much Jolly has left in the tank. While he's "old" (for an NFL player), he hasn't had as much wear and tear on his body (football-wise, at least) as others, so maybe there are 3,4,or 5 years left for him. Anyways, if Jolly does what we all hope he will, he will need to be paid next year, too.
They need to give him a stiff ankle brace. Once you sprain your ankle it takes a long time to get back to 100% and it will keep being injured again and again. We've had just terrible luck with first rounders in the last 4 years with serious injuries. 3 of them have serious injuries before season starts. Perry was hurt all last year.


text:
A Little Short Of Boats: The Fights At Ball's Bluff And Edward's Ferry, October 21-22, 1861 A History And Tour Guide
James A. Morgan
Publisher: Ironclad Pub
Publication Date: 2004
Binding: Softcover
Your Satisfaction is Guaranteed:
A Little Short Of Boats: The Fights At Ball's Bluff And Edward's Ferry, October 21-22, 1861 A History And Tour Guide: Search Results
1. |
Morgan, James A. Quantity Available: 1
Book Description: Ironclad Pub, Villa, Kentucky, U.S.A., 2004. Soft cover. Book Condition: New. No Jacket. 0967377048 Beautiful, Un-Read, New Book, Book Is Mint And True New Condition. A Clean, Bright, New Book. Not Remainder. Not Ex-Library. This Is A New Book. Bookseller Inventory # 020639 Bookseller & Payment Information | More Books from this Seller | Ask Bookseller a Question |
Portions of this page may be (c) 2006 Muze Inc. Some database content may also be provided by Baker & Taylor Inc. Copyright 1995-2006 Muze Inc. For personal non-commercial use only. All rights reserved. Content for books is owned by Baker & Taylor, Inc. or its licensors and is subject to copyright and all other protections provided by applicable law.
Portions of this page may be Copyright VNU Entertainment Media (UK) Ltd., 2006, Georg Lingenbrink GmbH & Co., Tite Live, S.A or Informazioni Editoriali S.p.A. All rights reserved.


text:
Had a brilliant week there. Very relaxing, clean and delicious breakfast. Would recommend this hotel to anyone. Room 117 is the best, and even has a bonus single en-suite room and a larger than average courtyard garden, with a sea view.
- Also Known As:
- VIK Suite Hotel Risco Del Gato Fuerteventura/Costa Calma
- Official Description (provided by the hotel):
- The VIK Suite Hotel Risco del Gato is an exclusive hotel with a unique architecture surrounded by 34.643 m² of gardens and heated swimming pools on different levels ... more less
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com, Expedia, Hotels.com, Splendia, Travelocity, Olotels, Priceline, Otel, Escapio and Tingo so you can book your VIK Suite Hotel Risco del Gato reservations with confidence. We help millions of travellers each month to find the perfect hotel for both holiday and business trips, always with the best discounts and special offers.


text:
Sea Star
Portrait of a Red and White sea star (Froma monilis), on a grey, rocky surface.
This image is available for use with credit to the photographer for non-commercial use. If you are interested in commercial use, please contact email@example.com.
To save the full sized image to your computer right click the Full Size link above (or control click on a Mac) and choose "Save Image As".


text:
December 28, 2011
Kyle Maistri InsidetheGators.com
Jon Halapio said interim offensive coordinator Brian White has taken a more hands on approach in practice than Charlie Weis did. ...More... To continue reading this article you must be a member. Sign Up Now for a FREE Trial
Already a member? Click here to sign in


text:
BBC WORLD NEWS: The latest global news from the world's largest news broadcaster. The newscasts contain all the most up-to-date news, interviews, analysis, business reports and world sports news.
Saturday, January 4th and Sunday, January 5th
The Essex Resort & Spa and Essex Cinemas
Essex, Vermont
Get your tickets today.


text:
The Beautiful and Bizarre Galapagos Islands
Evolution disciples and the merely curious can experience conspicuously adapted wildlife off the coast of Ecuador
- By Terence Monmaney
- Smithsonian magazine, January 2008, Subscribe
Giant tortoises lumber across the lava rocks, while iguanas defy desert stereotypes and plunge into the sea. The strange, conspicuously adapted wildlife that impressed Charles Darwin when he visited the Galápagos Islands in 1835—and that would later kindle his discovery of the process of evolution by natural selection—is still there. In fact, the Galápagos, 14 major and many smaller islands spanning the Equator 620 miles off the coast of Ecuador, remains the world's most biologically intact tropical archipelago.
But pollution, overfishing and development are harming efforts to conserve habitat and wildlife. A tourism boom is also taking its toll. The number of visitors has more than tripled in the past 15 years, to at least 145,000 in 2006. The islands are mostly under the control of Galapágos National Park, which restricts access to designated areas. Still, people over the years have unwittingly or deliberately introduced invasive life-forms that can undermine the natural order—some 750 alien plant species and 490 insect species, according to a 2007 report by the Charles Darwin Foundation. Scientists warn that the damage could be irreversible.
And yet the islands beckon. Evolution disciples should tread lightly, says Heather Hansen, co-author with Kimberly Lisagor of the soon-to-be published book Disappearing Destinations. To minimize the "Caribbeanesque chaos" of "uninvested tourists just stopping by for a day or two during a megacruise," Hansen recommends that travelers enlist only "outfitters that have a proven record of both environmental protection and a focus on enhancing the lives of the people who live there."
Subscribe now for more of Smithsonian's coverage on history, science and nature.
← Previous An Illuminated View of Iguazu Falls |
Smithsonian Life List: 43 Places to See Before You Die |
Next → Machu Picchu's Ancient Beauty |
Related topics: Travel Ecuador
Comments (1) |
why is this place so intresting xDDDD
Posted by yo mama on January 12,2011 | 02:05 PM
Thank you for encouraging the world to take a moment and see these wonders of the world. It has allowed me to realize how many I have seen. Also, to gather my friends and go and see the rest. So much to see and so little time. Above all do it as basic as possible or you will miss the local flavor that is what makes travel so much fun. Fancy hotels are fine, but do not let yourself be shielded from the real life of the local area.
Posted by Jim M. Muellner on January 8,2008 | 10:56 PM


text:
After spending nearly $40 million only to face devastating defeats in Iowa and New Hampshire, Howard Dean named a longtime friend of former Vice President Al Gore as his campaign chief on Wednesday, prompting the abrupt resignation of his campaign manager, Joe Trippi.
Dr. Dean said he had tapped Roy Neel, who was given the title of chief executive officer, to streamline day-to-day decision making as the Democratic presidential contest enters a lightning round of multistate contests. He said he had hoped to keep Mr. Trippi on as senior strategist.
But after a year of building the Dean juggernaut, from a staff of seven to what he has often called ''the greatest grass-roots movement in the history of American politics,'' Mr. Trippi refused to be sidelined, and walked out after what aides described as an emotional staff meeting here.
''You're going to see a leaner, meaner organization,'' Dr. Dean, who has asked his 500 staff members to skip their paychecks for two weeks, told reporters on an 8 p.m. conference call. ''We had really geared up for what we thought was going to be a front runner's campaign. It's not going to be a front-runner's campaign. It's going to be a long war of attrition. What we need is decision making that's centralized.''


text:
WHS Adoptable Animals
The Wisconsin Humane Society (WHS) is a private, nonprofit organization whose mission is to build a community where people value animals and treat them with respect and kindness. For more than 128 years, WHS has been saving the lives of animals in need. We offer adoption services that place 9,000 animals in new homes annually, veterinary services that save thousands of lives, educational programs that instill respect for animals, behavior services to assist guardians and a myriad of other initiatives that help end suffering for animals. We depend entirely on private donations to fund our programs and rely on volunteers in nearly every department. If you are interested in adopting, volunteering, enrolling in a class, taking a tour or making a donation, check out our comprehensive web site at wihumane.org. The adoptable animals' web pages are updated every 30 minutes!
2-week dog foster homes needed
Foster a PAL Dog
24-hr pet adoption event starts Saturday with free gifts!
24-hour adoption event kicks off Saturday morning at Wisconsin Humane Society
- FREE gifts for all adopters
- Kids crafts & scavenger hunt
- Beverly Hills Chihuahua will be shown FREE for families at 7:00 p.m. Saturday
- Puppy Pajama Parade – begins Saturday night at 10:10 p.m. sharp
- Wii/Just Dance Tournament begins at 11:00 p.m.
- Anyone adopting in pajamas 1:00 a.m. – 4:00 a.m. receives a 25% adoption discount
- CJ Astro will be hosting DOGA (yoga w/your dog) at 8:00 a.m. Sunday; FREE registration
WHS launches "virtual re-homing" for pets
The Wisconsin Humane Society (WHS) has launched a new "virtual re-homing" service for people seeking a new home for their animal. The Pets Seeking People page of the WHS web site features a listing of animals in the Milwaukee area who are in need of new homes. These animals are not in the WHS shelter, but are instead in their current homes until they find new guardians.
2-year-old Chocolate Lab
Looking for a new pup?
Meet Hadley, a 2-year-old Chocolate Labrador Retriever!


text:
Hang tight!
Recipe by Tammy Livingston
"This great recipe belonged to my Grandma and requires no cooking."
Watch video tips and tricks
2 cups graham cracker crumbs
3/4 cup white sugar
1/4 pound butter, melted
2 (8 ounce) packages cream cheese
1 1/2 cups confectioners' sugar
4 bananas, sliced
1 (15 ounce) can crushed pineapple, drained
1 (16 ounce) container frozen whipped topping, thawed
1 (16 ounce) jar maraschino cherries, drained
12 ounces crushed peanuts
This was my mothers recipe almost to the "T". a couple of things i have learned from making it over the years: 1. before putting on the cream cheese freeze the crust for a few hours, will make your life a lot easier 2. adding vanilla adds an excellent little flavor (it does get hidden amongst the flavors but you can tell its there) 3. soaking the bananas in the pineapple juice (dont get the heavy syrup kind) will keep the bananas from turning brown before you get to serve it. plus the pineapple/banana juice you just made tastes good too!!!
This was good on the first day, and much better the next day. Hubby and his friend liked it with chocolate syrup, but I thought that made the cake too sweet. My biggest complaint was that this cake, although good, was not worth the cost we paid for all the ingredients.
91 Ratings
I made this for my husband to take to work to celebrate a co-worker's birthday. I thought it would be an easy alternative to taking the fixings for real banana splits (which she loves!). Everyone loved it and requested the recipe. The co-worker liked it so much she took "leftovers" home for her children. The recipe is great but I made a few simple changes---less sugar in the crust mixture (cut to about 1/4 cup, used "light" cream cheese to cut fat, used fewer maraschino cherries, and kept the crushed peanuts to about 1/2-3/4 cup. It was still great! I will definitely make this one again.
I have made so many desserts from this site and this is the BEST recipe I have ever made. I did shave chocolate on top and it looked unbelievable. Thanks for sharing.
This is absolutely one of the best tasting desserts I've ever had. I remember my mom making it when I was a child and have never thought of it since until I read this recipe. The whole family loves it. It's going in our family favorites file, right now.
WOW! It was amazing! Made it for a small get together and got RAVE reviews! Subbed the peanuts for pecans....other then that i followed to the T. Great recipe! thanks!
HUGE hit with teenagers. (And adults who are teenagers at heart!) Had a bit of trouble spreading the cream cheese/sugar goo over the crumb crust. It kept sticking to the crust and wanting to pull it up. But I didn't give up, and the end result was a fantastic dessert! Thank you!
Delicious! I freeze the crust and cream cheese layers way ahead of time, to save work. I whip one pint of heavy cream rather than whipped topping. I thinly slice 4 cups of strawberrries, mixed with 2 tablespoons of sugar, rather than using the cherries. I layer the bananas, then pineapple, then strawberries, then whipped cream. I toast 1/2 cups of sliced almonds and sprinkle them on top, rather than peanuts. Our family likes this variation.
* Percent Daily Values are based on a 2,000 calorie diet.
Southern Style Banana Split Cake
Serving Size: 1/12 of a recipe Servings Per Recipe: 12 Amount Per Serving Calories: 748 Calories from Fat: 413
Get the season's best recipes for holiday feasting.
Holiday cookies, cakes, pies, and breads. Get recipes and inspiration.
Get time-saving recipes to save your busy life.
Who knew you could make a banana split even more delicious!
See how to make a luscious and creamy no-bake dessert!
Watch how to make this easy and fast banana cake.


text:
My name is Amanda. My name is also common, screw you people. I'm a nerd, and not usually in the cool way. Usually in the awkward way that doesn't go outside enough and makes jokes that no one else finds hilarious.
I dunno about you guys but I found CC's reaction hilarious.
(via xcapriciousminstrels-deactivate)


text:
Related video
The MiniVap™ joins the Ultravap™ in the state of the art 96 well sample evaporator units. The MiniVap™ is designed for the research and development end of the market when individual plates need drying.
Quicker dry down times than standard methods. Tests have shown that the MiniVap™ can evaporate 500µl of methanol in less than 10 minutes. Designed for any 96 well plate. Simple to install and operate. Easy adjustments of temperature, gas flow rates and needle depth into the wells. Compact foot print, will fit into all standard fume cupboards.
MiniVap™ Features:
- Quicker dry down times than standard methods such as vacuum oven
- Tests have shown that the MiniVap can evaporate 500μl of methanol in less than 6 minutes
- Designed for any ANSI/SBS 96 well plate
- 24 vial head now available
- Simple to install and operate
- Easy adjustments of temperature, gas flow rates and needle depth into the wells
- Compact footprint – fits all standard fume cupboards
Application notes and news
- Porvair Launches HPLC Sample Evaporators that Improve Throughput
- Parallel Sample Preparation System for HPLC Vials
- Personal Evaporator for HPLC Sample Preparation
- Porvair Announces Latest Version of the MiniVap-96 for Rapid Microplate Solvent Removal
- Drug Discovery 2009: Preparing Samples for Drug Discovery…
- Spotlight on microplate innovations…
- Driving progress in automated laboratory technologies...
- Microplate products for high throughput Drug Discovery...
- Microplate products for high throughput Drug Discovery...
- Microplate products for biomolecular screening
Request info
Write a review
Sharing your experience will help scientists like you. Achieve Reviewer Status and Win an iPad 3 (All reviews published will be entered into the next drawing on January 30th 2014).


text:
Giacometti Sculpture Sets New Record As Most Expensive Art
Wow, when I wrote about the upcoming auction of the Giacometti sculpture, L'Homme Qui Marche I, last month I had no idea that someone would go crazy for the bronze cast sculpture. But the results are crazy indeed. This sculpture, which was once part of the corporate collection of Germany's Dresdner Bank and acquired by Commerzbank when it took over Dresdner Bank last year, sold for an incredible £65,001,250 ($104,327,006) at the Sotheby's London Impressionist and Modern Art Evening Sale . It was only estimated at £12-18 million but it managed to set a world record as the most expensive piece of art ever to sell at auction breaking a record set way back in 2004 by Picasso's Garçon à la Pipe, 1905, which sold for $104.1 million.
The sale is good news for Commerzbank and selected German museums which will also benefit from the sale. The sculpture was executed in 1960 and cast in bronze in a numbered edition of 6 plus 4 artist's proofs. This one was cast in 1961 and is inscribed Alberto Giacometti and numbered 2/6 and with the foundry mark Susse Fondeur Paris. It seem Giacometti is in vogue lately. Last year his "L'Homme Qui Chavire" made the list of top pieces sold in 2009 in the ninth position with a price of $19.4 million.
Art Info reports that there was heated bidding both by phone and in person. While some thought the Giacometti might beat estimates no one imagined it would go for quite so much money. No information on the winning bidder has been revealed.


text:
Safety issues raised when motorists and bicyclists encounter each other on rural county roads will be discussed at a meeting of the Rural Lincoln Municipal Advisory Council on Monday, Sept. 19.
The meeting will take place at 7 p.m. in Mount Pleasant Hall, 3333 Mt. Pleasant Road, in rural Lincoln.
At the meeting, the advisory council will hear a report from David Martinez, a public information officer for the California Highway Patrol, on safety issues created by the presence of both automobile and bicycle traffic on county roads.
The Placer County Sheriff's Office also will have a representative to participate in the discussion.
The discussion will cover such topics as:
· State laws regarding motor vehicles and bicycles;
· The need for both bicyclists and motorists to obey posted signs and follow other rules of the road;
· Ways bicyclists and motorists can avoid conflicts with each other; and
· Statistics on bicycle use in Placer County.
Local bike clubs are invited to attend the meeting and participate in the discussion.
The rural Lincoln advisory body is one of 14 municipal advisory councils located throughout the county. Commonly known at MACs, they advise the Board of Supervisors on issues of public interest in unincorporated areas. They are charged with gathering public comment on a range of topics, including land use, public works, recreation, law enforcement and public health and safety.
The Rural Lincoln MAC normally meets at 7 p.m. on the third Monday of each month at Mount Pleasant Hall.
A map and directions to Mt. Pleasant Hall are posted on the website of Placer County Supervisor Robert M. Weygandt at http://www.placer.ca.gov/bos/District2.aspx. When the supervisor's home page appears, hit the "MACs" link on the left side of the page.
Supervisor Weygandt represents the Lincoln area on the Placer County Board of Supervisors.
For more information, call the Board of Supervisors Office at 530-889-4010.


text:
After posting a 7-5 regular season record during his inaugural campaign, we examine whether or not Coach Kingsbury earned an extension.
It was an eventful day, from Ann Arbor to Auburn, Ft Worth to Columbia. Most of it was the best, but one particular event was the worst.
Steve Addazio Named A Semi-finalist for coach of the year award.
Six quick thoughts on WVU Football.
Holgorsen presser, Kansas St. previews, WVU at Big 12 Media Day, recruiting updates, WVU Pros "Where are they now?", Big 12 roundup & more
Texas Tech previews, player features, Huggs presser, Luck on playoff committee, WVU Pros update, Big 12 roundup & more
If you thought something was going to happen this past weekend in the Big 12, you were probably wrong.
Chris B. of SmartFootball.com and Grantland.com has given the Air Raid offense a lot of thought. Here, he answers some questions from JP Fanshawe about why Hoglorsen's version of it is struggling this season.
WVU got a front row seat to the frighteningly efficient killing machine that is the Baylor Bears. A few of us lived to tell about it. Here is our story.
Join us commenting through our game thread for WVU's game against the Baylor Bears in Waco, Texas.
We'll email you a reset link.
If you signed up using a 3rd party account like Facebook or Twitter, please login with it instead.
You must be a member of Miner Rush to participate.
We have our own Community Guidelines at Miner Rush. You should read them.
You must be a member of Miner Rush to participate.
We have our own Community Guidelines at Miner Rush. You should read them.
Choose an available username to complete sign up.
In order to provide our users with a better overall experience, we ask for more information from Facebook when using it to login so that we can learn more about our audience and provide you with the best possible experience. We do not store specific user data and the sharing of it is not required to login with Facebook.