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In his address to the nation, President Obama explained the danger of chemical weapons and explained that a limited military strike would send a message to Bashar Assad. But there was no call to action. NBC's Chuck Todd reports.
President Barack Obama said Tuesday night that he would put off a military strike and work with Russia, China and American allies to force Syria to hand over its chemical weapons.
Obama, speaking from the East Room of the White House, said that the Syrian government's use of chemicals in an attack on rebels and civilians last month presented a danger to American security and violated the world's conscience.
The president, arguing a moral case to a country wearied by a decade of war, invoked gruesome images from the Aug. 21 attack outside the Syrian capital. He spoke of fathers clutching lifeless children, dead bodies lined up in rows and people left foaming at the mouth.
"Sometimes resolutions and statements of condemnation are simply not enough," he said. "What kind of world will we live in if the United States of America sees a dictator brazenly violate international law with poison gas and we choose to look the other way?"
Read the full transcript of the speech
Obama said he would work with other countries to pressure Syria to put its chemical weapons under international control and ultimately destroy them — a proposal that reshaped both the crisis and the president's address over two furious days of diplomacy.
Syrian rebels have told NBC's Richard Engel that President Bashar Assad has gotten away with killing hundreds of civilians with chemical weapons.
But Obama said he would order the military to stay in place in the region and to keep pressure on Bashar Assad, the Syrian leader, who the United States says ordered the attack against his opponents in Syria's civil war.
Obama pledged not to send American troops into Syria but warned: "The United States military doesn't do pinpricks. Even a limited strike will send a message to Assad that no other nation can deliver."
The president said American security was put at risk by the chemical attack. He said failing to respond would encourage Assad to use chemical weapons again, embolden other tyrants around the world and endanger U.S. allies, including Turkey, Jordan and Israel.
He said the United States could not be the world's police, "but when, with modest effort and risk, we can stop children from being gassed to death and thereby make our own children safer over the long run, I believe we should act. That's what makes America different. That's what makes us exceptional."
Public opinion polls have also showed consistent opposition to American military involvement in Syria. In a poll released Tuesday by NBC News and The Wall Street Journal, 58 percent of respondents said their member of Congress should vote against authorizing force, compared with 33 percent in favor.
And only 44 percent said they favored military action against Syria, even if it were limited to cruise missiles launched from Navy ships — a decline of six percentage points from a poll released late last month.
NBC News Virtual Town Hall: Weigh in on the speech
When Obama announced last Friday that he would address the nation on Syria, he was expected to issue a call to arms. But on Monday morning, the outlines of the crisis began to change by the hour.
By waiting and letting opposition build in the American public and in Congress, President Obama is now in a position where he has to rely on the Russian plan, NBC's Andrea Mitchell reports.
Secretary of State John Kerry said, almost offhandedly and in response to a reporter's question, that Syria could avert an American strike by putting his chemical weapons under international control.
Within hours, the Russian foreign minister, Sergei Lavrov, had presented just such a plan to Syria, a Russian ally, as a way to end the crisis, and Syria suggested that it welcomed the idea.
China and Iran also endorsed the plan. China is critical to the process partly because it holds veto power on the United Nations Security Council. The United States has considered the U.N. a dead-end for approving a Syria strike because of opposition from China and Russia.
On Tuesday, Russia added a wrinkle of complication: President Vladimir Putin said that a proposal for Syria to hand over its weapons would not work unless the United States and its allies promise not to use force.
In Congress, a small group of senators from both parties worked on language for a new resolution on Syria to include the surrender of chemical weapons. And a flurry of senators announced they would vote "no" on the previous resolution to authorize force, a resolution effectively made dead by the diplomatic developments.
In Syria, rebels told NBC News that they believe the proposal for Syria to hand over its chemical weapons is a ploy.
"There is anger and disappointment on the streets now," one opposition activist said in Damascus. "We have been facing death and under fire for the last two and half years while the world has been silent. Even after the use of chemical weapons, no one acted. We only have God to help us."
Richard Engel, Kelly O'Donnell, Chuck Todd and Kristen Welker of NBC News contributed to this report.
President Obama says that he'll continue to pursue diplomatic efforts, but if that fails, he wants a targeted military strike, and will not put American boots on the ground.
This story was originally published on Tue Sep 10, 2013 5:02 PM EDT


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Authors » Pat Jacobs
Pat Jacobs
Pat Jacobs was born in Collie, Western Australia. An historian, fiction writer and reviewer, she has received awards for both history and her short fiction published in Australian journals and anthologies. Her first book, Mister Neville, a biography of A.O. Neville, was published by Fremantle Press in 1990. Her novel, Going Inland, published in 1998, won the Western Australian Premier's Book Award for Fiction in 1991. The novel was nominated and long-listed for the 2000 Dublin Impac Award.
Winner, Western Australian Premier's Book Award, 1999
Nominated, Dublin IMPAC Award, 1999
Books available from Fremantle Press
- Going Inland 1998
- Going Inland ebook 1998
From the Catalogue
Whisky Charlie Foxtrot Reading
Annabel Smith's Whisky Charlie Foxtrot was shortlisted for the 2013 Most Underrated Book Award (MUBA). The winner, Fish-Hair Woman was announced on Friday night. Here's a reading Annabel prepared for her presentation at the Wheeler Centre award ceremony.

subset: commoncrawl


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Operation of Hope visits CURE Malawi
Earlier this month, CURE Malawi had the opportunity to host Operation of Hope. Operation of Hope is an organization that specializes in organizing plastic teams to provide surgeries to children with cleft lips and palates around the world. The team successfully completed 21 surgeries during their week and was a huge blessing to the hospital staff and the patients. Jennifer Trubenbach, Executive Director of Operation of Hope, was also very pleased with what her team was able to accomplish at the hospital. To show her appreciation, Jennifer sent the letter below to CURE. We hope you enjoy reading the thank-you message from Jennifer and taking a look at some of the pictures of the team!
Dear Friends:
I would like to thank each of you for the most amazing mission to BEIT CURE. Our team was grateful for all the support, warmth, and hospitality we received by the staff, administration, employees, and volunteers at BEIT CURE during our first visit to Malawi!
It was a true pleasure & a joy to partner with all of you in giving 21 deserving children new smiles!
We especially enjoyed working with the hard-working and dedicated theatre and ward staff, and a special thank you to Dr. Lubega and his team. And a special thank you to the ladies in the Cafe for your wonderful coffee, and to our drivers who brought us to and from the hospital every day!
Thank you from the bottom of our hearts for the opportunity to join you in helping these beautiful children; we look forward coming back… soon!
Blessings to all of you,
Jennifer & the team
Operation of Hope


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Survey of Energy Resources 2007
Solar Country Notes
The Romanian WEC Member Committee reports that the solar energy potential, as given by the average amount of energy from solar radiation on a horizontal surface, is about 1 300 kWh/m2/yr.
The geographical distribution of the solar energy potential indicates that more than half of Romania's area benefits from an annual energy flow of between
1 000 and 1 300 kWh/m2/yr. The solar-thermal potential is 144 000 TJ/yr, whilst the solar-electric potential is 6 TWh/yr.
The planned project and research programmes will promote investment projects in order to ensure optimum conditions for the development of medium and long-term applications.
The demonstration projects for heat generation based on solar sources are developed by means of high-performance solar-thermal systems (e.g. as a heat carrier and for hot-water production in individual households), which can operate in parallel with conventional heating systems.
For the development of demonstration programmes, especially for rural electrification, relatively low power (ranging from 200 W to 5 000 W) solar applications will be developed.
On the basis of feasibility studies, projects designed for PV grid-connected systems will be put into operation.
Current applications comprise:
demonstration grid-connected PV systems;
building-integrated grid-connected systems;
rural electrification;
small off-grid public & private installations;
hybrid PV/wind systems;
PV for telecommunications.


text:
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For more than 12 years the Bull Run Festival of Lights at Bull Run Regional Park has drawn thousands of visitors from hundreds of miles away to Centreville, Virginia, just outside Washington, DC. This year's festival opens November 21st and runs through January 6th, 2013! The Bull Run Festival of Lights is held each year to celebrate the winter holiday season. The event sees more than 30,000 cars each season, and over 130,000 people! Bull Run Festival of Lights is located just off of Interstate 66 in Centreville, on Rt. 29 (Lee Highway), just 3 miles from historic Manassas Battlefield Park.
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View courses and cost per credit for our International Business Bachelor's degree. Courses, course names, and cost per credit may vary by location. Download your state specific catalog for more information.
Choose your state or online to see your full course listing:
Course listings are subject to change. Please see our course catalog and/or addendum for most current listings.
Accelerated International Business Bachelor's Degree Course List
Major and Core Courses
Upper Division
This course will explore key concepts of international accounting and financial standards and reporting practices in the world economy considering external and internal factors to doing business globally. The course will study a variety of concepts dealing with theory and practice of accounting from a global standpoint. Students will apply skills in analyzing and interpreting accounting reports and financial statements of international corporations and organizations. Prerequisite: Financial Accounting II | Course ID: ACG 4133 |
Students will learn research and report writing for academic settings. Topics will include qualitative and quantitative research methodology, literature reviews, information literacy, and academic report writing. Prerequisite: English Composition or Professional Communication | Course ID: GEB 3110 |
This course is a study of the characteristics and functions of project management, team building, and facilitation. It places focus on project planning, scope, scheduling, and controlling of projects through completion. It reinforces and builds upon skills and knowledge students have learned in all of the various disciplines within the Business curriculum. It is recommended that students take this course their final quarter. Prerequisite: none | Course ID: GEB 3422 |
This seminar course examines diversity from a personal, group, organizational, national, and global perspective. Students will explore stereotypes of individuals within organizations, and they will study how these stereotypes affect people within the workplace. Students will also examine issues in conducting business and managing people within a global setting. Prerequisite: Principles of Management | Course ID: GEB 4220 |
In this course, students will develop basic statistical literacy along with the ability to analyze and evaluate real-life business problems using statistical methods. Students will learn to organize and present quantitative data by means of graphical and numerical methods. Topics include descriptive statistics, basic probability theory, discrete and continuous probability distributions, sampling distributions, estimation, hypothesis testing, analysis of variance, and simple linear regression. Prerequisite: none | Course ID: GEB 4310 |
This course is a study of concepts in international marketing dealing with the uniqueness of cross-cultural market challenges of global businesses. The focus will be placed on diversity encountered on the various target markets in the world. The notion of sensitivity and cultural dynamics dealing with the various world cultures is addressed as well as political and legal challenges, economic and educational issues, conducting research internationally, and many other topics dealing with promoting company and products abroad. Prerequisite: Principles of Marketing | Course ID: INS 3010 |
This course is a study of the key elements of legal and ethical issues when conducting business world-wide. It will examine principles, foundations, and institutions of international law regulating financial, maritime, commercial, and trade transactions across international frontiers. There are many topics under the umbrella of legal and ethical issues. This course intends to survey and apply a variety of these issues in an international setting. Prerequisite: Business Law | Course ID: INS 3072 |
This course is a study of the characteristics and functions of corporations conducting business in the global environments. The course will expose students to various global management aspects including annual reports, operations, and recent news dealing with the various corporations. Prerequisite: none | Course ID: INS 3125 |
This course is a study of concepts and issues of conducting business in today's technological global environment. The course will focus on the proper usage of various technology and communication tools that facilitate doing business from various locations around the world and on the go. The course involves a discussion of the use of communication and technology for the purpose of achieving and sustaining a competitive advantage in the world industries. Prerequisite: none | Course ID: INS 3203 |
This course is a study of the logistics operations in an international setting. The course will include a broad overview of supply chain management from an international perspective. This overview will include international logistics and the role of international logistics systems in global supply chain management. Prerequisite: none | Course ID: INS 3305 |
This course is a study of the issues of the use of technology in an international setting. This will include networking issues, data usage and communications, software and hardware requirements for proper technology use and communications, securing and encrypting technology in order to protect company assets and intellectual property, as well as various financial issues such as cost/benefit analysis dealing with the use of technology in a global corporation. Prerequisite: none | Course ID: INS 3526 |
This course is a study of the characteristics, theories and practices of global commerce, trade, and the economy from the perspective of utilizing various resources to conduct business internationally. It will involve the analysis of the functions, advantages, and disadvantages of the foreign exchange market as well as economic implications of the global financial markets. Prerequisite: Principles of Finance | Course ID: INS 4028 |
In this course, students apply the knowledge and skills they have learned in the International Business Bachelor of Science degree to a real-world business scenario. Key areas of focus include global management, international marketing, communication, travel, and technology, global trade, project management, and international accounting and finance. This course is designed to be taken at the end of the program. International Business Bachelor's student in last | Course ID: INS 4789 |
This seminar course examines current issues within the management field. This course is highly interactive in that both students and faculty are actively engaged in researching, presenting, and discussing course materials. In addition to gaining in-depth exposure to a current key topic in the field, students learn to become active and effective members of a professional learning community. Prerequisite: Principles of Management | Course ID: MAN 4143 |
This course is designed to explore human behavior in work settings from an interdisciplinary perspective. The following topics will be studied and analyzed from a management perspective: organizational structure, leadership, power, conflict management, individual and group dynamics, motivation, morale, and communication. Prerequisite: Introduction to Business | Course ID: MAN 4240 |
This course provides management students with an introduction to international economic, political, cultural and business environments. Students will develop a basic understanding and appreciation of the myriad factors involved in managing people within a global workforce. Prerequisite: Principles of Management | Course ID: MAN 4602 |
This course is designed to integrate prior business courses through study, discussion, and creation of strategic management plans. Students will evaluate the key functions of organizations and integration of these functions to understand the best practices used to achieve competitive advantages. Topics will include strategic formulation, implementation, and evaluation. Prerequisite: Introduction to Business | Course ID: MAN 4720 |
General Education Courses
Upper Division
Communication (Required course)
This course examines how people understand their world through visual images. Students will examine how people visually gather, process, and interpret information presented through media sources. Prerequisite: none | Course ID: MMC 3407 |
Humanities (Required courses)
This course introduces students to a variety of texts by American minority authors from the mid- 19th century to the present. The central focus of this course will be on literary responses to social marginalization based on race/ethnicity, gender, national origin, sexuality/sexual orientation, ability, and other factors. Students will study the effects of exclusionary and oppressive practices, both historical and present day, on writers' perceptions and literary representations of their times, contexts, and identity. Students will also be introduced to samples of the most common critical-theoretical approaches to the primary texts they will study in this class. Prerequisite: English | Course ID: AML 4680 |
The aim of this course is to understand and appreciate some important authors and traditions of political thought. The course will cover such topics as authority, consent, freedom and obligation. Prerequisite: none | Course ID: POT 4001 |
Math/Natural Sciences (Required course)
This course provides an in-depth exploration of the integrated relationship between human life and the surrounding environment, beginning with a study of the fundamental concepts and principles of ecology. Topics that are interwoven throughout the course include principles of ecology as seen in the structure and function of the ecosystem; pollution of air, soil, and water resources; population explosion and the relationship of people, disease, and food production; and environmental controls necessary for survival. Prerequisite: none | Course ID: EVR 3410 |
Social Sciences (Required courses)
Since the end of World War II, popular culture has become an especially significant aspect of American history and an important element in many of our lives. Consequently, this course will explore the ways in which popular culture has represented and mediated conflicts and tensions post-World War II. Through this lens, issues of gender and family relationships, as well as class and racial politics, will be discussed. The dual role of television as a reflective and manipulative force in the new suburban family and the role Hollywood films played in the popular culture will be examined. Prerequisite: none | Course ID: AMH 3304 |
This course will introduce students to the field of comparative politics by examining classification of political systems according to institutional and developmental characteristics. Causes and costs of political stability and instability will be explored. Comparison will be made between contemporary political institutions and processes in various countries. Prerequisite: American/US National Government | Course ID: CPO 4003 |
Total Bachelor's Degree Credits
Upper Division General Education Credits: 24
Upper Division Major and Core Credits: 66
Total Upper Division Credits: 90
Total BS Degree Credits: 181*
* Total credits above assume students enter in with a conferred Associate's degree which grants them a transfer block inclusive of lower division general education and lower division major and core courses.
Information for median loan amounts, on-time completion rates, and placement rates are unavailable for new programs (indicated with "NA*").
Our SUPPORT+ team will help you complete your financial aid application and review your financial aid award letter. Contact a financial services advisor to discuss your individual needs and goals.
The tuition shown is the full tuition cost and does not reflect scholarships, grants, loans, or any credit transfers-all of which can lower your tuition cost. Contact a program manager to discuss your unique situation and tuition costs for your degree.
Standard Occupational Classification (SOC) provides a representation of occupations for which graduates typically find employment
Standard Occupational Classification (SOC) provides a representation of occupations for which graduates typically find employment
Experience the value of our SUPPORT+ network of student services by speaking with one of our program managers. We'll assign the program manager best qualified to support and contact you by phone or email to discuss your future at Rasmussen College.
By requesting information, I authorize Rasmussen College to contact me by email, phone or text message at the number provided. There is no obligation to enroll.


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With his trademark guitar finger-picking and unmistakable songwriting voice, John Prine continues to
mesmerize diverse audiences with his humble poetry, describing often-overlooked crannies of everyday
life. With immeasurable accolades, including two Grammys and the distinction of being one of the few
songwriters honored by the Library of Congress and US Poet Laureate, Prine is more than a musician…he
is an American treasure.
See more info at johnprine.net
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I recently discovered J Prine on YouTube. He is amazing. If you love genuine Country music, you will love this guy. Discovered by K Kristofferson. Eddie from Radnor County
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Physical TherapistPhysical therapy means the evaluation, treatment and instruction of human beings to detect, assess, prevent, correct, alleviate and limit physical disability, bodily malfunction and pain from injury, disease and any other bodily condition; the administration, interpretation and evaluation of tests and measurements of bodily functions and structures for the purpose of treatment planning; the planning, administration, evaluation and modification of treatment and instruction; and the use of physical agents and procedures, activities and devices for preventive and therapeutic purposes; and the provision of consultative, educational and other advisory services for the purpose of reducing the incidence and severity of physical disability, bodily malfunction and pain. Application to Qualify for the PT Examination
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text:
At the 2011 Fluid Power Conference & Expo is being held at the Cleveland City Center Hotel in downtown Cleveland. John Treharn of Parker Hannifin is making an excellent presentation about the drivers of change for hydraulics.
A growing world population and all of the needs that go with developing countries, creates challenges for governments and companies supplying for these needs. It is clear that fluid power offers solutions and these are being discussed today in Cleveland.


text:
There ain't a cloud in sight
The title reminds me of the beginning of this popular song, been covered by a lot of people:
awko taco Originally Posted by Ruby To quote the great Location: "shut up scribz."
It's Mr. Blue Sky... Please, tell me you knew that.
Grassy Troll Conspiracy. Cloak and Swagger.
Originally Posted by ♠Ace♠ It's Mr. Blue Sky... Please, tell me you knew that. Not by title, but now I do.
Green grass grows on the ground as I expound above the sound,
Cyber Generation OOC http://roleplayerguild.com/showthrea...Generation-OOC
Forum Rules


text:
In 1931, The Times of London commissioned the Monotype Corporation, under the direction of Stanley Morison, to design a newspaper typeface.
According to Morison: The Times, as a newspaper in a class by itself, needed not a general trade type, however good, but a face whose strength of line, firmness of contour, and economy of space fulfilled the specific editorial needs of The Times. Times New Roman, drawn by Victor Lardent and initially released in 1932, was the result. More…
available in all of the styles:
only available in some of the styles:
available in all of the styles:


text:
You're watching...
Take foolproof holiday photos
Tips to make your picture perfect
Dec 14, 2012
You're watching...
Tips to make your picture perfect
Dec 14, 2012
Also in this playlist...
Auto-advance: ON
Auto-advanceThis transcript is automatically generated
It's all right great thanks -- don't spend hundreds of dollars on professional holiday pictures this year we're gonna show you how you can actually take don't -- perfect pictures.
With your own camera.
That's sweet would it is the president of unique photo in New Jersey and he joins us like you weren't great great to be here you know we're gonna take a lot of pictures over the next couple of weeks and I think the average person -- Whether they get that fancy.
SL are single lens reflex camera like -- -- the point shoot.
They put it on automatic and they just take all their pictures and that winds up with a picture like this where it's Internet it's a family action shut shot.
But the girls a little dark you can't we see what's going on and we think that well you know taking pictures.
That is what we do -- unique photo we.
We really try to work on getting you to turn the camera off the automatic mode getting to that get into the manual modes on the camera at a picture like that the camera senses the light.
In the area and doesn't realize that you really want a picture of the lovely young girl that's there.
And so what you do is you put the camera and a program Modi rotate that dial you -- the flash the fire in the camera at something called still flash did that thing with a little right -- the and then next -- you know.
With when you look at that you can actually see the detail on the ground it's beautiful picture right let's come down to the next month.
A lot of people are gonna be a plane and -- -- But I have gotten this picture many many times shooting the kids playing in the snow on automatic if -- everybody's a little blurry.
Yeah I mean this is one of those things to where you want to put the camera in its shutter priority mode because the camera will sense the bright snow the bright light.
And it won't pick a shutter speed which is fast enough and then when the children jump in the snow go up in the air.
People are so you have to force the shutter speed faster I would say a picture like this you're gonna shoot.
Maybe at thousands of the second OK and and if I don't know how to do the priority -- -- -- just going to like.
If it might cameras from icons I could switch around like it's a little thing absolutely a lot of the cameras today they have they have portrait -- sports mode all sorts of things like that they adjust the cameras really really well all right and they do -- they do a pretty good job okay now this would be in portrait mode it is it is.
-- nicely lighted but it's kind of awkward isn't it.
Well this is a little bit more of a sophisticated picture taking circumstance and this is why we obviously encourage you to -- -- -- hold a glass may be not the appropriate dress the kids -- -- kind of -- Betty have you never one of the things you want to do when you as a photographer -- you wanna control your subjects a little bit.
And you want to make sure that they don't do things that they wanna be photographed them because those photographs left forever and I'm not sure that the -- person and that photograph wants to have.
A glass -- -- -- wants to look like that and then the framing of the picture.
Really affects how.
So this is that kind of action you would like up a portrait to wind up bad.
But I you know it they're just seems to be -- different dynamic in this picture will.
What did the photographer tell these people that they didn't tell well he tried to get the expressions uniform in that picture they're all smiling they're all dressed the same he's framed it right we're not cutting -- heads off.
So you can see the picture provides a much more happy memory of what's gone on they don't look so happy in that picture you know can -- -- meanwhile it if you are like crap -- Clark Griswold he's been dead 25 days get ready for Christmas you got all your rights on your house.
You take that picture.
You know and if it's a little dark it probably should look more like this.
How do you get this instead of that OK a couple of things you need to do their first of all you need a timed exposure you need exposure that's a little longer than what the camera would set up.
In this case -- the camera focuses on the lights on the house -- it -- the camera into thinking the picture is brighter.
So you get a nice Canon T four I camera like that -- a man -- tried pot.
You set it up he said it into that shutter priority mode and you force the shutter to stay open a little bit longer it's called dragging the shutter and you're gonna get a much more composed picture.
Other shutter speed -- play with that a little bit but the other trick in that picture and this is a really really good tip is that this picture is taken sort of you have your Christmas -- you go out -- the feeling good -- you -- -- you take your -- -- picture of your lights.
This was taken right after sundown that's good and it that that you can see the blue -- that's correct.
How much but I you know I know the little point -- can be 5060 bucks if you want a nice camera right away and take fantastic pictures like this how much what I can NT four -- and 700 dollar 7800 dollar range.
But still it allows you to take a lot of variety of pictures is a more professional cameras the new Panasonic TH street is about a thirteen hundred dollar camera homeboy listen unique photos where he's -- you get to -- -- -- -- that's right -- new Jersey's largest camera store we have an amazing camera show the New Jersey camera show fifty vendors forty free classes this weekend.
You come on down to Fairfield New Jersey a -- 46 we'd love to see if they're earnest when -- -- good job thank you thank you very much.
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text:
I saw yesterday a post here in SE that I think was deleted. It was about the recently published MIT algorithm called "Eulerian Video Magnification for Revealing Subtle Changes in the World ACM Transaction on Graphics". The post was a little bit generic, but the subject was amazing. In the article link, you'll find a nice video that explains how it works. The algorithm is available in the page, but it's all implemented in MATLAB.
Here is one example on how can you see the blood flow, just using a regular camera.
My question is:
Can someone translate some of these MATLAB functions into Mathematica??
My favorite chalenge would be to see the face algorithm working with Dynamic[CurrentImage[]]
You will find a file called EVM_Matlab.zip
in the article page that has all the MATLAB functions needed to do the job. When you unpack it, you will find a file called README.txt
with all the instructions to test the algorithms. You can download the videos available in the page with you want to reproduce the tests (or download in the end of this post).
In the file reproduceResults.m
wil will find the script call used to start the video processing. For example, for the face algorithm, you have this call inside the file:
%% face
inFile = fullfile(dataDir,'face.mp4');
fprintf('Processing % s \n', inFile);
amplify_spatial_Gdown_temporal_ideal(inFile,resultsDir,50,4, ...
50/60,60/60,30, 1);
So the challenge is to implement this function amplify_spatial_Gdown_temporal_ideal
to solve the face example.
I created a zip file with all MATLAB algorithms and videos that can be download here (32MB)


text:
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Evista (generic: raloxifene) is a prescription medicine used to treat or prevent osteoporosis in postmenopausal women. It is also used to reduce the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are at risk of invasive breast cancer.
Evista belongs to a group of drugs called selective estrogen receptor modulators (SERMs). It works by mimicking the effects of estrogen to increase the density of bone.
This medication comes in tablet form. It is taken once a day with or without food.
Common side effects of Evista include hot flashes, leg cramps, swelling, and flu-like symptoms.


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I have stayed in their "standard" rooms and they look and feel like they are OLD. Old bed spreads, dark carpet. I always try to get one of their "mini suites" that consists of a couch in addition to the other normal amenities. These rooms are newer, but have recently become run down looking. The room I was in had... More
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so as the tittle says, I have Win 7 ultimate X64 is it worth it to upgrade to windows 8 X64? I can get it cheap like $20 bucks cheap but is it worth the hassle of re doing most things? does the "keep files and folders" thing actually work without bloating the o/s to crap?
It'll stuff your files (Users folder, windows folder and some other stuff) into "Windows.old" folder, meaning you'll be down 20+ GB on your system partition, and half the stuff you had won't be there anyway. The only real benefit W8 brings is Fast Boot, but it gets old fast as W8's overall agility drops faster than Vista's. Speaking from personal experience, 8 is going to start dragging it's feet after only 2 months - I reverted to 7 and am not looking back. And this is after installing the start button and cut-straight-to-desktop to mitigate the pesky Metro UI (don't get me started on that)...
Take a look in 1080p I haven't tried the non-metro but this gives a pretty good idea of the experience. Absolutely something you do not want on a non-touch device.
Some people love it, but I can't justify jumping thru hoops to get it where it is usable for myself when Win 7 does all I want already.
I tried multiple times to get it loaded and use it and like it. I've reloaded 7 each and every time. I will skip this os entirely in hopes of a non metro ui.
I have it in use on one of my notebooks, other than this...all Windows 7/Vista/XP/Mint machines. I sure wouldn't pay for it if you're thinking of upgrading...and you won't ever see me recommending it. Worthless in my opinion. Best, LC
No, it's not worth it. As you can get it for such a no-brainer price, it's worth having to play around with, but stick to W7 as your main OS. If MS actually release a patch to fix its most glaring shortcomings (mainly that Metro UI) then you might want to consider moving to it, but not before. Once you get to the desktop, it really feels like W7 with a square-edged, plain theme, which doesn't look too bad, but isn't a patch on the beautiful Aero desktop in W7.
Pros: Improved file explorer UI with more options Improved file transfer dialog with speed graph Proper multimonitor taskbar and wallpaper support Built in .iso mounting and burning Better task manager with more info OSD volume controls/display Built in Hyper-V (previously only avalible in server releases) Please note: however it is a bit stripped down Cons: Networking control accessed via the notifications panel is wierd Shutdown options are hidden in the charms bar Debatable: No start menu
Decided to become test rabbit in my office,and set up Win 8 Pro on my work laptop (1st generation i5 with SSD). Found out that its fast, like, real fast, needs touchscreen, and i can actually access my things at least as quickly as on Win 7. Getting the feeling that when i will fully adapt it to my needs (basically set up Start Menu and admins will work out quirks with integration into our domain) Win 7 can be put on shelf.
I was able to get my copies for $15 each back in October, installed StartIsBack (which I highly recommend) and it boots directly to the desktop, as far as performance, it's basically a bit faster than 7, mine hasn't slowed down since I installed it almost 6 mos. ago (maybe because I'm using SSDs on all my computers) and I really don't have any complains against it. The task manager is much improved over the one from previous releases (which has basically been the same since XP), it boots much faster, it has proper support for multi core processors, and once you add StartIsBack, is basically like having 7 with all those extra features, even the start menu is exactly the same. At first I didn't bother using the start screen and I would click on the desktop icon on every reboot, but now it boots directly to the desktop, and frankly I don't miss 7 at all. I have installed 8 Pro on all my computers and laptops, and if you were able to take advantage of the release price (Windows 8 Pro 64 bit for $15 + Media Center for free) I think you would've got a bargain. Hell, I even got a free copy of it with my Asus wireless AC router back in December, it's like MS was giving the OS away or something... Having said that, I would've never paid full price for the OS, and if you're happy wit Win7, I wouldn't recommend upgrading to 8 unless you find it on a sale or something. Also, you don't have to keep your old Win7 installation in your hard drive, you can always delete it after you make sure the OS migrated all your user files and settings, I found the experience of upgrading from Win7 to 8 to be quite painless, and the installation assistant included with Win8 is very robust. After a few weeks though I ended up nuking my OS partitions (I keep all my user files in a different partition on all my systems) and did free installations on all my PCs, as I found I had a lot of old programs previously installed on Win7 that I didn't use anymore, and it's always better to start on a clean slate with your OS.
Nope, not worth it at all, if you want 7 to be as "fast" as 8, just reinstall it (or try to clear everything irrelevant running in the background with autoruns from sysinternal) and disable some animation and fade from performance options (DON'T disable aero, that will disable HW acceleration too).
Been using Windows 8 Pro since it was out. Got it for $!5 I think because of that promo they were doing. Took a little time to get used to the new UI, which I like. I basically just went through trying stuff out, see what lead where, and such. I use the regular "Windows 7" desktop and not the Metro UI, but I still use the UI to open programs or search for things I want to get at. I don't use any of those Start button tools that add back the Start button as I don't feel like I need it. I can just simply press the Windows key and start typing to find the program/file I want. It takes maybe half a second to switch from the desktop to the new start menu. The only real gripe I have about Windows 8 are the apps. I just don't like how they work.
Funny that I've been doing that since, well, forever in 7 (and Vista), and it doesn't unilaterally took my whole damn screen with it.
Only reason I included that part was to imply that it doesn't take a significant amount of time to switch from the regular desktop to the Metro UI without having a start button on the desktop. It takes nearly the same amount of time to open a program on Windows 8 than it does on 7 through Metro compared to the start button.
It doesn't take any time AND significant screen real estate or distract me from anything I'm currently doing in 7, how is the whole flipping back and forth between a completely asinine interface help me in any way? Also, many user have reported that the sometimes you need to expand extra category first before getting your intended search result with W8, requiring extra steps and time. Those are subjectively minor but may add up in time and ultimately frustrates people rather than having any tangible benefit.
Window8 Error: 009 Unexplained error - Please tell us how this happened This has been hashed over so many times.... Window8 Error: 009 Unexplained error - Please tell us how this happened Window8 Error: 00E Mouse not found - A mouse driver has not been installed. Please click the left mouse button to continue. Window8 Error: oRD Rodney Dangerfield error - Press Respect key Only 36% of users found Win8 was worth the upgrade in a poll here. http://www.techpowerup.com/forums/showthread.php?t=179784
I run windows 8. If you are asking is it worth it for you to upgrade to win 8? Well that is something only you can decide. But for me it was.... I enjoy trying out the latest of everything. I'll tell you the OS is not as bad as people have said. And no you don't need a touch screen in order for windows 8 not to feel awkward. It actually feels fluid and just fine without one. I will say it did hurt my benchmarks for awhile until just recently. That was the only downside I noticed. I say go for it if you are someone who likes playing with the latest software and tech. But if that doesn't bother you.... than wait until there is a reason to upgrade. Like DX12 possibly in windows blue.
I was skeptical of Windows 8, but I decided to try it. I purchased and installed Windows 8 Pro x64, with StartIsBack. It starts up and shuts down faster than Windows 7, the general speed of the OS is faster than Windows 7 (to me.) The biggest plus of StartIsBack, is that Windows 8 boots straight to the desktop, there is an extremely functional start menu, and all of those ridiculous corner "charm" things are disabled.
There are some major improvements in the kernel and system utilities, for multitasking, multithreading, etc. Other than that, you get the new kids box-of-chocolates design and UI. Since I'm not a gamer and don't need DX11, I'm struggling to find a reason to upgrade my machines from XP. YES, I bought a copy of W8. It installs NICELY, and it boots NICELY. But once you get it working in a productive environment (installing ClassicShell etc.) then it really isn't giving me a significantly better experience or additional features. I struggle to find my upgrade rationale. Metro needs an upgrade to add the CLOSE button, to get mouse control back again without having to use a mouse to mimic some kind of phone gesture. An updated W8, aka W8.11 or W9 will I'm sure be great, and time to upgrade. But now? No.


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Cannabinoid receptor
cannabinoid receptor 1 (brain) | |
Identifiers | |
Symbol | CNR1 |
Alt. symbols | CNR |
Entrez | 1268 |
RefSeq | NM_033181 |
UniProt | P21554 |
Other data | |
Locus | Chr. 6 q14-q15 |
cannabinoid receptor 2 (macrophage) | |
Identifiers | |
Symbol | CNR2 |
Entrez | 1269 |
RefSeq | NM_001841 |
UniProt | P34972 |
Other data | |
Locus | Chr. 1 p |
The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily.[1][2][3] As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains.[4] Cannabinoid receptors are activated by three major groups of ligands, endocannabinoids (produced by the mammalian body), plant cannabinoids (such as THC, produced by the cannabis plant) and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and plant cannabinoids are lipophilic, i.e. fat soluble, compounds.
There are currently two known subtypes, termed CB1 and CB2.[5][6] The CB1 receptor is expressed mainly in the brain (central nervous system or "CNS"), but also in the lungs, liver and kidneys. The CB2 receptor is expressed mainly in the immune system and in hematopoietic cells.[7] Mounting evidence suggests that there are novel cannabinoid receptors[8] that is, non-CB1 and non-CB2, which are expressed in endothelial cells and in the CNS. In 2007, the binding of several cannabinoids to a G protein-coupled receptor (GPCR) in the brain was described.[9]
The protein sequences of CB1 and CB2 receptors are about 44% similar.[10] When only the transmembrane regions of the receptors are considered, amino acid similarity between the two receptor subtypes is approximately 68%.[4] In addition, minor variations in each receptor have been identified. Cannabinoids bind reversibly and stereo-selectively to the cannabinoid receptors. The affinity of an individual cannabinoid to each receptor determines the effect of that cannabinoid. Cannabinoids that bind more selectively to certain receptors are more desirable for medical usage.
Cannabinoid receptor type 1 (CB1) receptors are thought to be one of the most widely expressed G protein-coupled receptors in the brain. This is due to endocannabinoid-mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission. Endocannabinoids released from the depolarized post-synaptic neuron bind to CB1 receptors in the pre-synaptic neuron and cause a reduction in GABA release.
They are also found in other parts of the body. For instance, in the liver, activation of the CB1 receptor is known to increase de novo lipogenesis.[11] Activation of presynaptic CB1 receptors is also known to inhibit sympathetic innervation of blood vessels and contributes to the suppression of the neurogenic vasopressor response in septic shock.[12]
A 2004 study suggested that the endocannabinoids and their cannabinoid receptors play a major role during pre- and postnatal development.[13]
A study done on CB1 knockout mice (genetically altered mice that cannot produce CB1) showed an increase in mortality rate. They also displayed suppressed locomotor activity as well as hypoalgesia (decreased pain sensitivity). The CB1 knockout mice did respond to Δ9-tetrahydrocannabinol, or THC. This shows that either CB2 or unknown cannabinoid receptors also have pharmacologic significance.[14]
CB2 receptors are mainly expressed on T cells of the immune system, on macrophages and B cells, and in hematopoietic cells. They also have a function in keratinocytes, and are expressed on mouse pre-implantation embryos. They are also expressed on peripheral nerve terminals. These receptors play a role in antinociception, or the relief of pain. In the brain, they are mainly expressed by microglial cells, where their role remains unclear. While the most likely cellular targets and executors of the CB2 receptor-mediated effects of endocannabinoids or synthetic agonists are the immune and immune-derived cells (e.g. leukocytes, various populations of T and B lymphocytes, monocytes/macrophages, dendritic cells, mast cells, microglia in the brain, Kupffer cells in the liver, etc.), the number of other potential cellular targets is expanding, now including endothelial and smooth muscle cells, fibroblasts of various origins, cardiomyocytes, and certain neuronal elements of the peripheral or central nervous systems.[7]
Other cannabinoid receptors[edit]
The existence of additional cannabinoid receptors has long been suspected, due to the actions of compounds such as abnormal cannabidiol that produce cannabinoid-like effects on blood pressure and inflammation, yet do not activate either CB1 or CB2.[15][16][17] Recent research strongly supports the hypothesis that the N-arachidonoyl glycine (NAGly) receptor GPR18 is the molecular identity of the abnormal cannabidiol receptor and additionally suggests that NAGly, the endogenous lipid metabolite of anandamide (also known as arachidonoylethanolamide or AEA), initiates directed microglial migration in the CNS through activation of GPR18.[18] Other molecular biology studies have suggested that the orphan receptor GPR55 should in fact be characterised as a cannabinoid receptor, on the basis of sequence homology at the binding site. Subsequent studies showed that GPR55 does indeed respond to cannabinoid ligands.[9][19] This profile as a distinct non-CB1/CB2 receptor that responds to a variety of both endogenous and exogenous cannabinoid ligands, has led some groups to suggest GPR55 should be categorized as the CB3 receptor, and this re-classification may follow in time.[20] However this is complicated by the fact that another possible cannabinoid receptor has been discovered in the hippocampus, although its gene has not yet been cloned,[21] suggesting that there may be at least two more cannabinoid receptors to be discovered, in addition to the two that are already known. GPR119 has been suggested as a fifth possible cannabinoid receptor.[22]
Cannabinoid receptors are activated by cannabinoids, generated naturally inside the body (endocannabinoids) or introduced into the body as cannabis or a related synthetic compound.
After the receptor is engaged, multiple intracellular signal transduction pathways are activated. At first, it was thought that cannabinoid receptors mainly inhibited the enzyme adenylate cyclase (and thereby the production of the second messenger molecule cyclic AMP), and positively influenced inwardly rectifying potassium channels (=Kir or IRK).[23] However, a much more complex picture has appeared in different cell types, implicating other potassium ion channels, calcium channels, protein kinase A and C, Raf-1, ERK, JNK, p38, c-fos, c-jun and many more.[23]
Separation between the therapeutically undesirable psychotropic effects, and the clinically desirable ones, however, has not been reported with agonists that bind to cannabinoid receptors. THC, as well as the two major endogenous compounds identified so far that bind to the cannabinoid receptors —anandamide and 2-arachidonylglycerol (2-AG)— produce most of their effects by binding to both the CB1 and CB2 cannabinoid receptors. While the effects mediated by CB1, mostly in the central nervous system, have been thoroughly investigated, those mediated by CB2 are not equally well defined.
Gastrointestinal activity[edit]
Inhibition of gastrointestinal activity has been observed after administration of Δ9-THC, or of anandamide. This effect has been assumed to be CB1-mediated since the specific CB1 antagonist SR 141716A (Rimonabant) blocks the effect. Another report, however, suggests that inhibition of intestinal motility may also have a CB2-mediated component.[24]
Cardiovascular activity[edit]
Cannabinoids are well known for their cardiovascular activity. Activation of peripheral CB1 receptors contributes to hemorrhagic and endotoxin-induced hypotension. Anandamide and 2-AG, produced by macrophages and platelets respectively, may mediate this effect.
The hypotension in hemorrhaged rats was prevented by the CB1 antagonist SR 141716A. Recently the same group found that anandamide-induced mesenteric vasodilation is mediated by an endothelially located SR 141716A-sensitive "anandamide receptor," distinct from the CB1 cannabinoid receptor, and that activation of such a receptor by an endocannabinoid, possibly anandamide, contributes to endotoxin-induced mesenteric vasodilation in vivo. The highly potent synthetic cannabinoid HU-210, as well as 2-AG, had no mesenteric vasodilator activity. Furthermore it was shown that mesenteric vasodilation by anandamide apparently has 2 components, one mediated by a SR 141716-sensitive non-CB1 receptor (located on the endothelium) and the other by an SR 141716A-resistant direct action on vascular smooth muscle.
The production of 2-AG is enhanced in normal, but not in endothelium-denuded rat aorta on stimulation with Carbachol, an acetylcholine receptor agonist. 2-AG potently reduces blood pressure in rats and may represent an endothelium-derived hypotensive factor.
Recent studies have also suggested that activation of CB1 receptors in human and rodent cardiomyocytes,[25][26] coronary artery endothelial and inflammatory cells[27][28][29][30] promotes activation of mitogen-activated protein (MAP) kinases p38 and JNK, reactive oxygen species generation, cell death, and cardiovascular inflammatory response both in vitro, as well as in models of heart failure, atherosclerosis and vascular inflammation.[25][26][27][29][30]
Anandamide attenuates the early phase or the late phase of pain behavior produced by formalin-induced chemical damage. This effect is produced by interaction with CB1 (or CB1-like) receptors, located on peripheral endings of sensory neurons involved in pain transmission. Palmitylethanolamide, which like anandamide is present in the skin, also exhibits peripheral antinociceptive activity during the late phase of pain behavior. Palmitylethanolamide, however does not bind to either CB1 or CB2. Its analgesic activity is blocked by the substance that was once thought to be a specific CB2 antagonist, SR 144528, though not by the specific CB1 antagonist SR 141716A (rimonabant). Hence, a CB2-like receptor was postulated.
In experiments on mice, a chemical designated JZL184 that inhibits a naturally occurring enzyme MAGL from degrading a pain-relieving endocannabinoid called 2-arachidonoylglycerol (AG) increases the brain concentration of AG, thereby inducing analgesia.[31][32]
The endocannabinoid system through CB2 signaling plays a key role in the maintenance of bone mass. CB2 is expressed in osteoblasts, osteocytes, and osteoclasts. CB2 agonists enhance endocortical osteoblast number and activity while restraining trabecular osteoclastogenesis. Another important effect is that CB2 agonists attenuates ovariectomy-induced bone loss while increasing cortical thickness. These findings suggest CB2 offers a potential molecular target for the diagnosis and treatment of osteoporosis.[33]
Cannabinoid treatments[edit]
Cannabis preparations have been known as therapeutic agents against various diseases for millennia.[34] The psychoactive compound tetrahydrocannabinol (THC) was found to be the principal mediator of the effects of cannabis.[35] Synthetic THC is prescribed today, under the INN dronabinol or the brand name Marinol, to treat vomiting and for enhancement of appetite, mainly in AIDS patients.
Several synthetic cannabinoids have been shown to bind to the CB2 receptor with a higher affinity than to the CB1 receptor.[36] Most of these compounds exhibit only modest selectivity. One of the described compounds, a classical THC-type cannabinoid, L-759,656, in which the phenolic group is blocked as a methyl ether, has a CB1/CB2 binding ratio > 1000.[37] The pharmacology of these agonists has yet to be described.
Certain tumors, especially gliomas, express CB2 receptors. Guzman and coworkers have shown that Δ9-tetrahydrocannabinol and WIN-55,212-2, two non-selective cannabinoid agonists, induce the regression or eradication of malignant brain tumors in rats and mice.[38] CB2 selective agonists are effective in the treatment of pain, various inflammatory diseases in different animal models,[33][39] osteoporosis[33] and atherosclerosis.[40] CB1 selective antagonists have previously been used for weight reduction and smoking cessation (see Rimonabant). Activation of CB1 provides neuroprotection after brain injury.[41]
Several studies, using animal models, have concluded that HU210 which is a cannabinoid 100 to 800 times more potent than marijuana compounds might have the ability to prevent Alzheimer's disease.[42][43] But a more recent study using mice carrying human genetic mutations that cause Alzheimer's disease found that those same cannabinoides have no effect on Alzheimer's disease and have negative consequences for cognitive function, including causing brain cell death.[44]
Binding affinity and selectivity of cannabinoid ligands[edit]
CB1 affinity (Ki) | Efficacy towards CB1 | CB2 affinity (Ki) | Efficacy towards CB2 | Type | References | |
Anandamide | 78nM | Full agonist | 370nM | ? | Endogenous | |
N-Arachidonoyl dopamine | ? | Agonist | ? | ? | Endogenous | |
2-Arachidonoylglycerol | ? | Full agonist | ? | ? | Endogenous | |
2-Arachidonyl glyceryl ether | 21 nM | Full agonist | 480nM | Full agonist | Endogenous | |
Tetrahydrocannabinol | 10nM | Partial agonist | 24nM | Partial agonist | Phytogenic | [45][45] |
EGCG | 33.6μM | Agonist | >50μM | ? | Phytogenic | |
AM-1221 | 52.3nM | Agonist | 0.28nM | Agonist | Synthetic | [46] |
AM-1235 | 1.5nM | Agonist | 20.4nM | Agonist | Synthetic | [47] |
AM-2232 | 0.28nM | Agonist | 1.48nM | Agonist | Synthetic | [47] |
UR-144 | 150nM | Full agonist | 1.8nM | Full agonist | Synthetic | [48] |
JWH-007 | 9.0nM | Agonist | 2.94nM | Agonist | Synthetic | [49] |
JWH-015 | 383nM | Agonist | 13.8nM | Agonist | Synthetic | [49] |
JWH-018 | 9.00 ± 5.00 nM | Full agonist | 2.94 ± 2.65 nM | Full agonist | Synthetic | [50] |
NMR Imaging[edit]
The protein image was created using nuclear magnetic resonance to determine 3-D structure. The picture represents the fourth cytoplasmic loop of the CB1 cannabinoid receptor.
See also[edit]
- ^ Howlett AC (August 2002). "The cannabinoid receptors". Prostaglandins Other Lipid Mediat. 68-69: 619–31. doi:10.1016/S0090-6980(02)00060-6. PMID 12432948.
- ^ Mackie K (May 2008). "Cannabinoid receptors: where they are and what they do". J. Neuroendocrinol. 20 Suppl 1: 10–4. doi:10.1111/j.1365-2826.2008.01671.x. PMID 18426493.
- ^ Graham ES, Ashton JC, Glass M (2009). "Cannabinoid receptors: a brief history and "what's hot"". Front. Biosci. 14 (14): 944–57. doi:10.2741/3288. PMID 19273110.
- ^ a b Sylvaine G, Sophie M, Marchand J, Dussossoy D, Carriere D, Carayon P, Monsif B, Shire D, LE Fur G, Casellas P (1995). "Expression of Central and Peripheral Cannabinoid Receptors in Human Immune Tissues and Leukocyte Subpopulations". Eur J Biochem. 232 (1): 54–61. doi:10.1111/j.1432-1033.1995.tb20780.x. PMID 7556170.
- ^ Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990). "Structure of a cannabinoid receptor and functional expression of the cloned cDNA". Nature 346 (6284): 561–4. doi:10.1038/346561a0. PMID 2165569.
- ^ Gérard CM, Mollereau C, Vassart G, Parmentier M (1991). "Molecular cloning of a human cannabinoid receptor which is also expressed in testis". Biochem. J. 279 (Pt 1): 129–34. PMC 1151556. PMID 1718258.
- ^ a b Pacher P, Mechoulam R (2011). "Is lipid signaling through cannabinoid 2 receptors part of a protective system?". Prog Lipid Res. 50 (2): 193–211. doi:10.1016/j.plipres.2011.01.001. PMC 3062638. PMID 21295074.
- ^ Begg M, Pacher P, Bátkai S, Osei-Hyiaman D, Offertáler L, Mo FM, Liu J, Kunos G (2005). "Evidence for novel cannabinoid receptors". Pharmacol. Ther. 106 (2): 133–45. doi:10.1016/j.pharmthera.2004.11.005. PMID 15866316.
- ^ a b Ryberg E, Larsson N, Sjögren S, Hjorth S, Hermansson NO, Leonova J, Elebring T, Nilsson K, Drmota T, Greasley PJ (2007). "The orphan receptor GPR55 is a novel cannabinoid receptor". Br. J. Pharmacol. 152 (7): 1092–1101. doi:10.1038/sj.bjp.0707460. PMC 2095107. PMID 17876302.
- ^ Munro S, Thomas KL, Abu-Shaar M (1993). "Molecular characterization of a peripheral receptor for cannabinoids". Nature 365 (6441): 61–65. doi:10.1038/365061a0. PMID 7689702.
- ^ Osei-Hyiaman D, DePetrillo M, Pacher P, Liu J, Radaeva S, Bátkai S, Harvey-White J, Mackie K, Offertáler L, Wang L, Kunos G (2005). "Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity". J. Clin. Invest. 115 (5): 1298–305. doi:10.1172/JCI23057. PMC 1087161. PMID 15864349.
- ^ Godlewski G, Malinowska B, Schlicker E (2004). "Presynaptic cannabinoid CB1 receptors are involved in the inhibition of the neurogenic vasopressor response during septic shock in pithed rats". Br. J. Pharmacol. 142 (4): 701–8. doi:10.1038/sj.bjp.0705839. PMC 1575049. PMID 15159284.
- ^ "The endocannabinoid-CB1 receptor system in pre- and postnatal life" - Ester Fride, "European Journal of Pharmacology" (Volume 500, Issues 1–3, 1 October 2004, Pages 289–297)
- ^ Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, Bonner TI TI (1999). "Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice". Proceedings of the National Academy of Sciences of the United States of America 96 (10): 5780–5. doi:10.1073/pnas.96.10.5780. PMC 21937. PMID 10318961.
- ^ Járai Z, Wagner JA, Varga K, Lake KD, Compton DR, Martin BR, Zimmer AM, Bonner TI, Buckley NE, Mezey E, Razdan RK, Zimmer A, Kunos G (November 1999). "Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 14136–41. doi:10.1073/pnas.96.24.14136. PMC 24203. PMID 10570211.
- ^ Ho WS, Hiley CR (April 2003). "Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery". Br. J. Pharmacol. 138 (7): 1320–32. doi:10.1038/sj.bjp.0705160. PMC 1573773. PMID 12711633.
- ^ McHugh D, Tanner C, Mechoulam R, Pertwee RG, Ross RA (February 2008). "Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2". Mol. Pharmacol. 73 (2): 441–50. doi:10.1124/mol.107.041863. PMID 17965195.
- ^ McHugh D, Hu SS-J, Rimmerman N , Juknat A, Vogel Z, Walker JM, Bradshaw HB (March 2010). "N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor". BMC Neuroscience 11: 44. doi:10.1186/1471-2202-11-44. PMC 2865488. PMID 20346144.
- ^ Johns DG, Behm DJ, Walker DJ, Ao Z, Shapland EM, Daniels DA, Riddick M, Dowell S, Staton PC, Green P, Shabon U, Bao W, Aiyar N, Yue TL, Brown AJ, Morrison AD, Douglas SA (November 2007). "The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects". Br. J. Pharmacol. 152 (5): 825–31. doi:10.1038/sj.bjp.0707419. PMC 2190033. PMID 17704827.
- ^ Overton HA, Babbs AJ, Doel SM, Fyfe MC, Gardner LS, Griffin G, Jackson HC, Procter MJ, Rasamison CM, Tang-Christensen M, Widdowson PS, Williams GM, Reynet C (March 2006). "Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents". Cell Metab. 3 (3): 167–75. doi:10.1016/j.cmet.2006.02.004. PMID 16517404.
- ^ de Fonseca FR, Schneider M (June 2008). "The endogenous cannabinoid system and drug addiction: 20 years after the discovery of the CB1 receptor". Addict Biol 13 (2): 143–6. doi:10.1111/j.1369-1600.2008.00116.x. PMID 18482429.
- ^ Brown AJ (November 2007). "Novel cannabinoid receptors". Br. J. Pharmacol. 152 (5): 567–75. doi:10.1038/sj.bjp.0707481. PMC 2190013. PMID 17906678.
- ^ a b Demuth DG, Molleman A (2006). "Cannabinoid signalling". Life Sci. 78 (6): 549–63. doi:10.1016/j.lfs.2005.05.055. PMID 16109430.
- ^ Mathison R, Ho W, Pittman QJ, Davison JS, Sharkey KA (2004). "Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats". Br. J. Pharmacol. 142 (8): 1247–54. doi:10.1038/sj.bjp.0705889. PMC 1575196. PMID 15249429.
- ^ a b Mukhopadhyay P, Bátkai S, Rajesh M, Czifra N, Harvey-White J, Haskó G, Zsengeller Z, Gerard NP, Liaudet L, Kunos G, Pacher P. (2007). "Pharmacological Inhibition of CB1 Cannabinoid Receptor Protects Against Doxorubicin-Induced Cardiotoxicity". J Am Coll Cardiol. 50 (6): 528–36. doi:10.1016/j.jacc.2007.03.057.x. PMC 2239316. PMID 17678736.
- ^ a b Mukhopadhyay P, Rajesh M, Bátkai S, Patel V, Kashiwaya Y, Liaudet L, Evgenov OV, Mackie K, Haskó G, Pacher P (2010). "CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes". Cardiovasc Res. 85 (4): 773–784. doi:10.1093/cvr/cvp369. PMC 2819835. PMID 19942623.
- ^ a b Rajesh M, Mukhopadhyay P, Haskó G, Liaudet L, Mackie K, Pacher P (2010). "CB1 cannabinoid receptors promote oxidative/nitrosative stress, inflammation and cell death in a murine nephropathy model". Br J Pharmacol. 160 (3): 657–668. doi:10.1111/j.1476-5381.2010.00769.x. PMC 2931565. PMID 20590572.
- ^ Han KH, Lim S, Ryu J, Lee CW, Kim Y, Kang JH, Kang SS, Ahn YK, Park CS, Kim JJ. (2009). "CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages". Cardiovasc Res. 84 (3): 378–86. doi:10.1093/cvr/cvp240. PMID 19596672.
- ^ a b Sugamura K, Sugiyama S, Nozaki T, Matsuzawa Y, Izumiya Y, Miyata K, Nakayama M, Kaikita K, Obata T, Takeya M, Ogawa H. (2009). "Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages". Circulation. 119 (1): 28–36. doi:10.1161/CIRCULATIONAHA.108.811992. PMID 19103987.
- ^ a b Mukhopadhyay P, Horváth B, Rajesh M, Matsumoto S, Saito K, Bátkai S, Patel V, Tanchian G, Gao RY, Cravatt BF, Haskó G, Pacher P. (2011). "Fatty acid amide hydrolase is a key regulator of the endocannabinoid-induced myocardial tissue injury". Free Radic Biol Med. 50 (1): 179–195. doi:10.1016/j.freeradbiomed.2010.11.002. PMC 3022384. PMID 21070851.
- ^ "Cannabis-like drug dims pain without the high". News. COSMOS magazine. 2008-11-24. Retrieved 2008-12-02.
- ^ Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, Pavón FJ, Serrano AM, Selley DE, Parsons LH, Lichtman AH, Cravatt BF (November 2008). "Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects". Nat. Chem. Biol. 5 (1): 37–44. doi:10.1038/nchembio.129. PMC 2605181. PMID 19029917.
- ^ a b c Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, Tam J, Attar-Namdar M, Kram V, Shohami E, Mechoulam R, Zimmer A, Bab I (January 2006). "Peripheral cannabinoid receptor, CB2, regulates bone mass". Proc. Natl. Acad. Sci. U.S.A. 103 (3): 696–701. doi:10.1073/pnas.0504187103. PMC 1334629. PMID 16407142.
- ^ Pacher P, Bátkai S, Kunos G (2006). "The Endocannabinoid System as an Emerging Target of Pharmacotherapy". Pharmacol. Rev. 58 (3): 389–462. doi:10.1124/pr.58.3.2. PMC 2241751. PMID 16968947.
- ^ Gaoni Y, Mechoulam R (1964). "Isolation, structure and partial synthesis of an active constituent of hashish". J. Am. Chem. Soc. 86 (8): 1646–1647. doi:10.1021/ja01062a046.
- ^ Ashton JC, Wright JL, McPartland JM, Tyndall JD (2008). "Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists". Curr. Med. Chem. 15 (14): 1428–43. doi:10.2174/092986708784567716. PMID 18537620.
- ^ Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG (February 1999). "Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630". Br. J. Pharmacol. 126 (3): 665–72. doi:10.1038/sj.bjp.0702351. PMC 1565857. PMID 10188977.
- ^ Galve-Roperh I, Sánchez C, Cortés ML, del Pulgar TG, Izquierdo M, Guzmán M (2000). "Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation". Nat. Med. 6 (3): 313–9. doi:10.1038/73171. PMID 10700234.
- ^ Whiteside GT, Lee GP, Valenzano KJ (2007). "The role of the cannabinoid CB2 receptor in pain transmission and therapeutic potential of small molecule CB2 receptor agonists". Curr. Med. Chem. 14 (8): 917–36. doi:10.2174/092986707780363023. PMID 17430144.
- ^ Steffens S, Veillard NR, Arnaud C, Pelli G, Burger F, Staub C, Karsak M, Zimmer A, Frossard JL, Mach F (2005). "Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice". Nature 434 (7034): 782–6. doi:10.1038/nature03389. PMID 15815632.
- ^ Panikashvili D, Simeonidou C, Ben-Shabat S, Hanuš L, Breuer A, Mechoulam R, Shohami E (2001). "An endogenous cannabinoid (2-AG) is neuroprotective after brain injury". Nature 413 (6855): 527–31. doi:10.1038/35097089. PMID 11586361.
- ^ Ramíirez, B. G., C. Blázquez, T. Gómez del Pulgar, M. Guzmán, and M. L. de Ceballos (2005). "Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation". Journal of Neuroscience 25 (8^): 1904–1913. doi:10.1523/JNEUROSCI.4540-04.2005. PMID 15728830. Retrieved 2007-02-27.
- ^ Marchalant Y, Cerbai F, Brothers HM, Wenk GL (December 2008). "Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats". Neurobiol. Aging 29 (12): 1894–901. doi:10.1016/j.neurobiolaging.2007.04.028. PMC 2586121. PMID 17561311. Lay summary – The Lantern.
- ^ Chen B, Bromley-Brits K, He G, Cai F, Zhang X, Song W (May 2010). "Effect of synthetic cannabinoid HU210 on memory deficits and neuropathology in Alzheimer's disease mouse model". Curr Alzheimer Res 7 (3): 255–61. doi:10.2174/156720510791050948. PMID 20043809. Lay summary – e! Science News.
- ^ a b "PDSP Database - UNC". Retrieved 11 June 2013.
- ^ WO patent 200128557, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2001-06-07
- ^ a b US patent 7241799, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2007-07-10
- ^ Frost JM, Dart MJ, Tietje KR, Garrison TR, Grayson GK, Daza AV, El-Kouhen OF, Yao BB, Hsieh GC, Pai M, Zhu CZ, Chandran P, Meyer MD (January 2010). "Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity". J. Med. Chem. 53 (1): 295–315. doi:10.1021/jm901214q. PMID 19921781.
- ^ a b Aung MM, Griffin G, Huffman JW, Wu M, Keel C, Yang B, Showalter VM, Abood ME, Martin BR (August 2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2)receptor binding". Drug Alcohol Depend 60 (2): 133–40. doi:10.1016/S0376-8716(99)00152-0. PMID 10940540.
- ^ Aung, M.M. et al. (2000). "Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding". Drug and Alcohol Dependence 60: 133–140.
External links[edit]
- Cannabinoid Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
- The Endocannabinoid System Network (ECSN) - CB1 receptor
- "Cannabinoid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.


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2012-04-26 06:20
President Lee's security adviser on visit to Washington
WASHINGTON (Yonhap) -- A top Korean presidential official is visiting the United States for consultations on North Korea and bilateral alliance issues, a government source said Wednesday.
Kim Tae-hyo, senior secretary to President Lee Myung-bak for national security strategy, arrived in Washington Monday for meetings with officials at the White House, the State Department and the Defense Department, according to the source. They include National Security Adviser Tom Donilon, the source said. Kim is "visiting Washington and is in consultations with U.S. officials on the North Korean nuclear program, missiles, North Korea policy and other major pending issues between South Korea and the U.S.," the source said, requesting anonymity. His trip comes as Seoul and Washington are on alert for a possible nuclear test by North Korea or other provocations. The North on April 13 fired a long-range rocket that fell apart shortly after liftoff. In New York, Kim had discussions Sunday with U.N. officials on the Security Council's recent statement strongly condemning the North's rocket launch. He reportedly visited Washington twice in 2011 to talk about North Korea policy and the South Korea-U.S. free trade agreement. He plans to return to Seoul on Friday. |


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And when all was said and done, all 120 in attendance were heroes.
Five awards were handed out, including the Citizen of the Year, which went to Pam Adamson, The Daily Home/St. Clair Times marketing director
The Small Business Award went to Animal Shelter of Pell City; The Large Business Award went to Northside Medical Associates; The Small Industry Award went to American Waste Services: and the Large Industry Award went to CenturyLink.
Chamber Executive Director Lynn Batemon said she stood up and looked out as Willis was singing and thought, "You know, there is a little bit of hero in everything. The businesses and individuals who were represented here today are what make Pell City go. It's just a good feeling and my heart just filled up."
Guest speaker was Pell City High School head football coach David Shores.
Citizen of the Year
Adamson said it is an honor to be named Citizen of the Year, but the other four women nominated were just as deserving.
"I have lived in Pell City since 1974, and it is such an honor to be named its Citizen of the Year," Adamson said. "It's great to have grown up here, and to be able to work civically side by side with people I grew up with. It is great to see Pell City growing like it is. It's wonderful just to be part of it all."
Small Business
Helen Powell is president of the Board of Directors for the Animal Shelter of Pell City Inc. She said being named Business of the Year is wonderful.
"We've been in business now for 11 years and we're making progress because we're trying to work ourselves out of business," Powell said. "What we want to do is decrease the number of animals that come to us for care. This is the first year since we've been open that our incoming numbers have declined during the year. I do believe that's because of our spay/neuter program so we can fix the animals in the county so they don't reproduce. We also hope it's because of our education program where people are learning not to let their animals roam and not let them reproduce at will.
Large Business
Ronnie Harris is Human Resources manager with Northside Medical Associates. He said it is a great time and a great recognition for the employees at Northside Medical Associates.
"Our employees work very hard in doing what they do in serving the community," Harris said. "We have seven physicians, six nurse practitioners, four managers and 53 employees. I am proud of every one of them."
Small Industry
The winner was American Waste Services.
Large Industry
Gary Smith is with CenturyLink and he thanked mainly the 40 employees who are located specifically in Pell City.
"We have a large group who are very dedicated to the community," Smith said. "On behalf of CenturyLink as a company, with the acquisition of Quest, we have become the third largest telecommunication company in the country and 45,000 employees strong. We want to thank the city of Pell City for this award."
Contact Gary Hanner at email@example.com.


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Ebeltoft Feriehusudlejning - Djursland -East Jutland
Visit our website to see all the new photos. We have many wonderful holiday homes for rental some of which have a sea view, spa pool or an indoor swimming pool. Many of our holiday homes are available as saver holidays where you book the house for two weeks but only pay for 10 days, and in 2007 we will discount holidays with 25% off selected holiday homes, provided that max. two people stay in them. Minibreaks are available for many of our holiday homes outside the high season and guests may also book an arrival date of their own choice.
Opening hours | ||
01/01/2012 - 31/12/2014 | Monday - Sunday | - |


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You are Owen MacLeod...the Highlander. Born over 2000 years ago and still alive, you are Immortal. Moving through the centuries you have fought to survive against other Immortals in legendary battles where death comes only by beheading. Now, a mysterious figure has unleashed a series of attacks on New York, intent on tracking down MacLeod. Owen soon learns that his only chance to defeat this mysterious figure, and thus save his own head, lies in reuniting the three fragments of a mysterious stone that, when whole, is reputed to bring unlimited power to the Immortal that possesses it. Sensing that his destiny is closely linked to this ancient artifact, MacLeod must sift through his memories, plunging him into three key periods of his past, and leading him inevitably toward his ultimate destiny: one final battle against his greatest enemy.
This game is marked as Canceled for all known regions, so we don't expect any cheats, FAQs, or reviews for it.
The Highlander message board has 47 topics and 228 messages.
And More...
For this game, we also have a page with release details and information, 1 box shot, 5 GameSpot screenshots. You can track this game and add it to your collection using My Games, and you can find out how to contribute to GameFAQs at Contributor Central.


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On Being a Dad, Part II
"Dad" is the affectionate term. My kids call me dad. Of course, there are times that my daughter calls me "father" with a British accent, but that's just how we roll. Being a dad is sometimes about identity and sometimes about not having one at all. You're famous and infamous. You're up-front and you're behind the scenes. Mom is yes, and dad is no. You're the one that sets the boundaries, but you're also the one who can break them. You have your spot at the dinner table, but not in your kids social life (not that they want, anyway). It's a dichotomy that is dad.
Here's what is amazing about all of that: Your kids know you. They know your tendencies. They know your spot at the table and the recliner. They probably know what show you're going to watch on Monday night. And since Alf isn't on any more, you're probably watching MNF. Your kids know how you're going to react to their report card and the presence or lack of A's on it. They know if they should give it to you when they walk in the door or just before going to bed.
My daughter knows if I'll approve of her new boyfriend or not, because, well, I won't. No matter what. Only if JJ Watt or Peyton Manning walked in would I have a momentary hesitation in judgment.
Your boys are going to know how much trouble they are in before you get home. Mine do.
If they know my your wife told you already, they know it's bad. They also know how you'll react if it's a surprise. They know if they should be in their room (probably cleaning it with 4 different chemicals and toothbrush), or if it will be safe to be on the couch.
Why do they know all this? Because you're dad. They watch you. They follow you. Your influence on them is like no other. That's why they know you like they do. They probably do a good impression of you behind your back. That's okay. Just know this; we have to make sure that we are living a life and being the example that we want them to follow.
When my wife told my boys one day to help with the dishes, one my her sons argued that he didn't want to because, "that's a girl's job." Yikes. Quick introspection…have I given them that impression? What have I said–no–what have I done that would give them that impression? And which couch do I sleep on tonight?
Since then, I try to make the dishes my job. As much as possible. I'll also make them help me. I don't want to raise my boys to think that they don't have a reason to have dishpan hands. I also don't want them to one day marry a young lady and have unrealistic expectations.
Now, that's just one area. Their rooms usually look like they are the back lot in Sanford and Son. That's not my wife's fault. That's on me. I've taught them that's okay. I've got to change that one. Of course, I'd like to go in there with 47 boxes and tell them to kiss most of it goodbye, but that's frowned upon in this establishment.
Be there men. Your kids are watching you like mine watch me. Make it a life worth watching.
Train up a child in the way which he should go and when he is old he will not depart from it. Proverbs 22:6


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PC Vulnerabilities Rise At Alarming Rate
July 15, 2010 0 CommentsJust got done reading this article this morning and it got my attention. PC vulnerabilities are increasing exponentially compared to last year. It is only July and we have gotten to 90% of where we were at this time last year. Which means there will most likely be twice as many as last year.
Many of these vulnerabilities are coming from third party software vendors. The best way to remediate these vulnerabilities for end users is to head over to Secunia and let them scan your PC. It will look at all available software on your system and provide you with links to make sure you have the latest versions, which can go along way in preventing your PC from being hacked. You can also read their report for yourself. Take the time to patch your system!! If you are not comfortable doing this, by all means, we can help ...
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Nicolas Cage's Las Vegas Home Finally Sold
Filed under: Estates, Celebrity Shopping
Cage, who had a variety of properties scattered all around the world, picked up this home in 2006 for $8.5 million. In July 2008 he listed it for $9.95 million. The 14,000-square-foot home with a 16-car garage was later discounted to $9.49 million. The seven-bedroom home is blandly extravagant with a sweeping staircase, home theater, elevator and panoramic views of Las Vegas. The home has a pool and spa and is located in a gated community for privacy. After it was foreclosed it got a discount in line with current Las Vegas prices, Lowman sold Cage's former home for close to the asking price of $4,950,000.
Last November Cage's New Orleans homes were sold back to the bank for a total of $4.5 million. His Rhode Island home still appears to be listed at $12 million.


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Home Styles Arts and Crafts 5 Piece Dining Set
Ground / Parcel Shipping
Home Styles Arts and Crafts 5 Piece Dining Set
Home Styles' Arts & Crafts 5 Piece Dining Set includes a dining table and four chairs that complement it perfectly. The table is available in options of rich multi step Cottage Oak or Ebony finish making it both durable and eye-catching. This unit is suitable for any dining room décor and adds a touch of style and grace to your home.
The solid oak construction ensures durability and will provide you with long years of use. The table is fully extendable, allowing you to seat four to six people in your home easily thanks to its ability to stretch from 48" to 66".
Wholly dependable:
The use of solid hardwood means you have worry-free operation for yearsBeautiful aesthetics:
Available in options of Cottage Oak or Ebony, the unit will stand outClassic design:
This unit is suitable for any dining room décor thanks to its classic design
Ground or USPS deliveries do not include a guaranteed delivery date. Should you require a specific delivery date or expedited shipping please add the item to the shopping cart and view the shipping options drop down box. If the product is eligible for expedited shipping the shipping options and pricing will be listed. Please contact our customer service department with any questions related to shipping. (800) 297-6076, M-F, 8am to 5pm CST.


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A Jackie Robinson moment?
on April 30, 2013 @ 5:54 am (Updated: 9:14 am - 4/30/13 )
Life is complicated.
In any case, gay rights groups see Collins announcement as a breakthrough because pro sports is considered the last bastion of homophobia ... the question is why? It can't be that gay equals sissy because Jason Collins is 7 feet, 255 pounds, and he runs through the Santa Monica mountains wearing a 30-pound workout vest to stay in shape.
No, apparently it's the same thing that spooked the military for 20 years.
It's the showers. Guys are scared of what might happen in the showers. And so, in his coming out essay in Sports Illustrated, Collins tried to reassure everybody, quote, "Believe me, I've taken plenty of showers in 12 seasons. My behavior wasn't an issue before, and it won't be one now."
This has been called a Jackie Robinson moment. Except that before Jackie Robinson joined the Dodgers, there were no black players in the majors. Whereas Jason Collins has played in the NBA for 12 seasons and he's been gay - and taking showers while gay - the whole time.
And he's pretty sure he's not the only one.
I don't know how he'll fare in the locker room, but at 7 feet and 255 pounds, he should do OK everywhere else.
Dave Ross hosts the Morning News on KIRO Radio weekdays from 5-9 a.m., and the co-host of The Ross & Burbank Show on KIRO Radio, weekdays 9-10 a.m.
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'Reunion' tops DVD sales, rental charts
July 20th, 2012
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LOS ANGELES, July 19 (UPI) — The raunchy comedy "American Reunion" is the top-selling DVD and Blu-ray, and No. 1 rental in the United States, Rentrak reported Thursday.
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'Reunion' tops DVD sales, rental charts
Categories: Movie News airport, boots, cinder-block, divorce-him, driving-drunk, fark, husband-had, lol-wut, prudence, starbucks, the-airport, your-neighbor


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Danker Jan Oreel
Artist Oreel, Danker Jan
Available series in store category "Comic books"
Danker Jan Oreel in the
"Danker Jan Oreel was born in Breda, where he also attended the St. Joost Art Academy. He began his career working at the illustration department of a publishing house, making among others (advertising) illustrations for Black & Decker, Chrompack and the Dutch educational television. He..." [ Read more ]


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4 Minute Warning is back and will build on last year in the form of a 'latest forecast', but the fundamentals remain the same – the world is changing and fast. 4 Minute Warning provides delegates... Read more
Marketers must evolve to meet the expectations and demands of the multichannel customer. If you have not already transformed your customer engagement processes into integrated, customer-centric... Read more
Nothing brings you closer to the consumer than mobile. And nothing brings you closer to understanding how to influence mobile moments like the MMA's EMEA Forum. By breaking this conversation down... Read more


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Dark Golden-Eggplant Shadow
Step 1: Lay down a base with an eggplant/plum metallic pencil, such as Rimmel Exaggerate in 220 Perfect Plum. Apply it thickly along the top and bottom lash lines, and then fill in the rest of the lids. Fnish by smudging out the top edges so it fades into the socket line.
Step 2: Apply a dark plum or eggplant purple to the outer and inner corners diagonally, slanting up and out. I used MAC Extra Dimension Eye Shadow in Rich Core, but you can use any shimmery dark purple or plum.
Step 3: In the center of the lid where the diagonal gap is, pack on a pale champagne gold shimmer. I used Sephora Prisma Chrome shadow in Moon Beam. (I was one of those who got the mis-named/re-named batch of Moon Beams that is a pale gold instead of a pale ivory pink duochrome.) Choose any pale golden-beige shade.
Step 4: Finish with a touch of gold along the inner corners of the lower lash line as well, then proceed to apply lots of mascara.


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December 6, 2012 at 866 × 628 in How design helps ChangeMakrs be quotable, and maybe profitable
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Say hello to fall's best new fits and washes—with styling tips from the designers themselves!
Whether you're a light-wash kind of girl or someone who goes for midnight-black studded styles, we've found the best on-the-cusp denim to wear this fall. Click through to read up on all the best need-to-know brands!


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Personal Care Sea to Summit Personal Care Shower Personal Care
(based on 1 review)
Ratings Distribution
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Reviewed by 1 customer
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(1 of 1 customers found this review helpful)
Light and sturdy, touchy valve & smelly
By hpskiff
from Los Angeles, ca
About Me Casual/ Recreational
Best Uses
Comments about Sea To Summit Pocket Shower:
Bought the solar shower mainly to use for hand washing and light clean up around camp as the camp grounds we stay at usually have showers. It is light and compact, but has a valve that is very touchy. It has to be closed just right or it leaks, too tight and too loose both cause it to leak. Also the plastic (PVC I believe) that lines the bag to make it water tight gives off a very strong plastic odor which gets into the water. Then your hands, hair and what ever else you wash smells too. I have tried rinsing it, leaving it filled for 2 days and dish soap, but the smell remains.
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From Sennheiser
Product From Sennheiser
The HMEC25 KA headset is available from Sennheiser Electronic Corporation. Only 5.9 ounces, comes with split headband, reversible and flexible boom, and mic/phone/power connector options. The newest configuration, the HMEC25-KAP, powers the ANC through the mic tip, eliminating the need for the batter pack or additional power plug. -
Expand for more details on this Product
Airport Surface Detection Equipment, Model X (ASDE-X)
Product From Saab Sensis Corporation -
ASDE-X fuses ground surveillance data from a number of sources to provide air traffic controllers with real-time, highly accurate position and location information of all aircraft and vehicles on the airport surface. By combining surface movement radar, transponder multilateration and Automatic Dependent Surveillance – Broadcast (ADS-B), ASDE-X provides seamless, redundant coverage in all weather conditions. The system also features an advanced conflict detection and alerting technology, Safety Logic, which uses complex algorithms to discern and alert controllers of potential aircraft or vehicle incursions on the runway.
Multistatic Dependent Surveillance (MDS)
Product From Saab Sensis Corporation -
Sensis MDS uses multiple low-maintenance, non-rotating sensors to triangulate aircraft location based on transponder signals and supply air traffic controllers with precise aircraft position and identification information regardless of weather conditions. With a higher update rate and greater positional accuracy than traditional radar, Sensis MDS provides consistent, accurate surveillance performance. MDS' architecture and advanced multi-path elimination algorithms result in precise surveillance using the optimal number of ground stations for reduced cost and complexity. Additionally, every MDS sensor supports Automatic Dependent Surveillance – Broadcast (ADS-B) for easy migration to future technologies.
IC-A3-VHF Air Band Transceiver
Product From EDMO Distributors Inc. -
The IC-A3-VHF Air Band Transceiver portable all-channel handheld radio is distributed by EDMO Distributors Inc. Designed for high audio output and features an ergonomic keybad.
- Product From David Clark Company Inc.
The H3530 headset, designed for communications and hearing protection for ground support personnel is available from David Clark Company.
Economical 'Live' Voice Messaging
Product From Ritron, Inc. -
Loudmouth® Wireless PA system from Ritron, Inc., allows airports to use an existing portable two-way radio, base station or mobile radio to deliver "live" voice messages at a distance of up to two miles away. It is ideal for general paging or announcements, weather emergencies, security announcements, and more, for military or civilian operations. This proven, cost-effective technology requires no trenching and no extensive wiring.
- Product From Comprehensive Technical Solutions
CTS' M2 is a high quality, classically styled pushback headset with a budget friendly price. CTS can supply quality push-back communications equipment including headsets, heavy-duty extension and splitter cables.
- Product From Flightcom Corporation
Flightcom's wireless headset system enhances safety, efficiency and crew communication. It is designed for pushback, towing, deicing, maintenance, cargo and other applications.
- Product From Flightcom Corporation
Wireless Headset Communication System for Deicing Operations – Our wireless headsets keep the driver and sprayer in constant two-way voice communication like a phone call. Superior audio quality; proven in wide deployment.
Pilot Director- TDTL (SWAPs) Severe Weather Aircraft Parking System (PAATs) Park At Any Time System
Product From IST International Ltd. -
Ideal for airlines & ground support engineers (GSE). Keeps traffic moving in bad weather, lightning, and De-Ice operations. Giving pilots added safety and visibility while directing them into the terminal. Able to stop, slow, and direct the airliner right, left, or forward. The marshals are safe and secure inside a tug or vehicle equipped with these cost saving systems. No missed flights or reschedules, reduces fuel taxiing. Get your passengers to their destinations without delay! Pays for itself in 2-4 uses! NO-tarmac delays, no fines, especially with the passenger rights law. Airlines have already been fined $100,000-$375,000. Most progressive Airlines/FBO have been using for over 10 years. Safety Aircraft Parking.
Equipment & Tool Tracking Software
Product From Dynamic Systems Inc. -
Track Who, Where, When
Toolroom tracks Who took the tool, Where it is now and When it is due back. Companies find that by having current information on the location of critical tools, the time spent looking for the right tool is eliminated and the employees' frustration is reduced.