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The vampire Darius fears for the life of his half-breed daughter, who is unaware of her unusual destiny. To oversee her transformation, Darius seeks help from Wrath, a dangerous loner and the world's only purebred vampire.
In the shadows of the night in Caldwell, New York, there's a deadly turf war going on between vampires and their slayers. There also exists a secret band of brothers like no other - six vampire warriors, defenders of their race. Among them, none relishes killing their enemies more than Wrath,... read more (warning: may contain spoilers)
"If you're going to bloody the human, would you be good enough to do it in the backyard?"Fritz to the Brotherhood about Butch
"Would you like me to give you a ride home?" he asked. Only if it were raining thumbtacks and hairpins, you letch."Dick / Beth's thoughts
"Welcome to the wonderful world of jealousy, he thought. For the price of admission, you get a splitting headache, a nearly irresistible urge to commit murder, and an inferiority complex. Yippee."Wrath
"Get out of my sight before I get out my knife!"Zsadist
"Beth Randall, this is Rhage. An associate of mine. Rhage, this is Beth, and she doesn't do movie stars, got it?"Wrath
"Nobody kills the human but me."Wrath to the Brotherhood about Butch
"Tell me something, boys. Do you wear that leather to turn each other on? I mean, is it a dick thing with you all?"Butch drawled to the Brotherhood
"Blondie's dying to get his hands on me. I can't help it."Butch about Rhage
"So if the chicks won't do you, what makes you think I'd want to?"Rhage to Butch
"You know, I kind of like this big dummy."Rhage about Butch
"Yeah, no Tom, Dick, and Harry names for the vampire types. But come on, could you actually imagine some lethal bloodsucker named Howard? Eugene? Oh no, Wallie, please don't bite my-- Holy Christ, he was totally losing it. What time was it?"Butch
"Ah, now, don't get all mushy on me. We ain't dating."Butch to Vishous
"Worship me, gentlemen, and I might let you play with the buttons."Vishous
"I'm going to talk to her." "And how's that going to go? You're just going to walk up to her and say, 'Hey, I know you've never seen me before, but I'm your dad. Oh, and guess what? You've won the evolutionary lottery: You're a vampire. Let's go to Disneyland !'"Darius to Tohrment
"I'll cab it home." "Naw. I'll hang until you're through. Then I'll drag you back to your apartment. Watch you throw up for an hour. Push you into bed. Before I leave I'll get the coffee machine set up. Aspirin will be right next to the sugar bowl."Butch & Jose
"If he'd been a gentleman, he'd have left her alone. Yeah, and when was the last time he'd lived up to his pedigree?"Wrath
"Ah, hell. The female did something to his brain. Somehow managed to unplug his well developed self-control and put him in touch with his inner fricking psycho. It was a connection he wanted to avoid. After all, fits of insanity were Rhage's specialty. And the brothers didn't need another hair-trigger loose cannon in the group."Wrath
"Man, he wasn't going to need a stress test anytime soon. If his heart could get through a kiss from her, he could probably run a marathon. While dragging a car behind him. Sideways to the road."Butch
"Come on, man. What does it matter to me? You, Tohr. Britney Spears." "Was that a joke, Z? After all this time, have you finally found your sense of humor? Hell, you're giving me another reason to live."Zsadist & Wrath
"You don't know this yet," he said grimly. "But you are mine."Wrath
"Don't trust me. Don't like me. I could give a shit. But don't you ever lie to me."Wrath
"Perfect date material, she thought. A vampire with the social equivalent of road rage."Beth about Wrath
"Hey, they like you." "And thank God for that"Wrath and Beth
"You've won the evolutionary lottery: You're a vampire. Let's go to Disneyland!"Tohrment
Chapter 1 - 55
Followed by Lover Eternal.
Followed by Lover Eternal.
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Haiti: "We are not out of the emergency phase yet"February 12, 2010
Dr. Marie-Pierre Allié, president of Médecins Sans Frontières-France, who recently returned from a field visit to Haiti, analyses the situation there one month after the disaster. At present, areas of concern include the vacuum caused by the withdrawal of some of the international medical teams who rushed to scene after the earthquake, the ongoing lack of shelter, and the slow pace of aid distribution.
The extent of the destruction that I observed in the field is very unusual. This disaster leaves a profound impression even on those with prior experience in natural disasters, even after seeing the images over and over. In some places, families are living in the rubble of neighborhoods that have been completely destroyed. In other areas, the buildings still standing seem to be very unstable and dangerous. According to the United Nations, approximately 500,000 displaced persons have moved to more than 300 resettlement sites in the capital, but this is just part of the problem. We are talking about a capital city of 2.5 million people where almost no one is sleeping under a roof at this point.
We are not out of the emergency phase yet. At this point, there are two particularly important issues. Overall, it is essential to provide shelter faster. When hundreds of thousands of families are living unprotected from the weather, in crowded sites with few latrines, you've got a major health risk. No epidemics have been noted to date, but living conditions could promote the spread of a host of illnesses, specifically diarrhea and skin infections. The rainy season begins in a few weeks and we could see increased respiratory infections. We are already observing a spread of these illnesses among our patients.
Some of the emergency medical teams sent by other countries are leaving, although their patients still require treatment. Many of the wounded who were operated on need revision surgery and full post-operative care, which require weeks of hospitalization. Our teams have sharply expanded their post-operative capacity and continue to work on that issue. We are organizing comprehensive services, including medical and nursing care, physical therapy and psychological support. The needs in this area are now considerable, but the resources are now being cut back. The public hospitals need to free up beds so that they can resume their normal activities. It's premature for the other international medical teams to be leaving. It is too early for a return to normal. The rapid withdrawal of international teams after just a few weeks is not appropriate in a context like this one, where many wounded people require care for some period of time. This is a recurring issue in this kind of crisis. We saw it in Pakistan, after the 2005 earthquake, and after the tsunami.
The massive mobilization by certain countries to help the Haitians definitely had positive impacts. Significant resources were deployed, for example, to bring key infrastructure like the airport and port back into operation. The next question is, again, one of priorities. Should the assisting country first set up its headquarters and ensure the comfort of its troops–or would it be a better idea to give the country's authorities the resources they need to carry out their role? During a meeting with the Minister of Health in Port-au-Prince, I was struck by the very limited resources available to the Ministry's staff. The lack of coordination in the medical area posed a problem during the first two weeks. It occurred that our teams were assessing needs in a specific area and starting to work, while other teams wanted to launch their activities in the same place.
It's normal to see a delay of a few days before aid arrives in the field and a few weeks before resources are deployed to cover all needs. In Haiti's case, the needs are unusually extensive and the arrival and deployment of aid was necessarily slow and perceived as inadequate. This is a new kind of situation that involves massive destruction in a capital city. The Haitian government and the U.N. staff on site were harmed directly and physically, and took additional time to be able to organize an effective response. Tags: Haiti Earthquake 2010, Haiti |

subset: commoncrawl


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The bier card was a golden opportunity to set BSB apart from the pool of comparable establishments. If anything, that should have been focused on for success only. Otherwise when you come down to saying that outside of the bier card, you are just like everywhere else, that really hurts in promoting your brand. If you are just like everywhere else, why don't I just go everywhere else?
I will cut some slack on the servers and their lack of knowledge since that takes time for most new places to overcome. I may try BSB again in a couple of months to see if they have improved. But if they are either no different or if what makes them different is not better, then I don't expect this to be a true and successful biergarten for the many in Charleston who are well-versed in beer.
We want to show some love to Bay Street Biergarten as they showed us love when allowing Bison Branding to vinyl wrap their truck.
I'll have to agree with the naysayers—I think the self-service aspect is a novelty that may be fun to play with once or twice, but I wouldn't be shocked if they start to gather dust once the initial wave of interest dies down a bit. I'd recommend The Craftsmen on Cumberland St. if you're looking for a wide selection and don't want to be punished for not wanting to play bartender. That said, brunch chicken waffles are outstanding and it's a good spot to catch a game.
General FYI: For those of you that aren't a fan of the bier card and/or don't want to learn how to use it, Bay Street has all of the amenities of a normal restaurant/bar. All of the beers at the the tables are in fact available behind the bar. The only beers that require a bier card purchase are those at the craft beer tasting wall (which consists of 6 rotating unique and harder to find craft beers). Additionally, the non-communal tap tables do not require a card and are "activated" by a server. The staff is always eager to help those that want to learn how the system works and learn how to pour their own beer. The card and tap tables are meant to be an educational tool but it is obviously not for everyone. For those that aren't interested in the tap system, there is food, liquor, wine and a huge beer selection that you can easily order the "old fashioned way." PS: the "get a life" comment was not an inside job... but this is :) We hope this clears up some confusion. Prost!
It's frustrating because if you want to order a beer from the taps throughout the restaurant you have to use a prepaid card which charges you by the oz even if only foam comes out. Also hard to view the selection of taps when the restaurant is busy also feels like you're intruding on other customers dinner if you want to go get a specific beer. Then if you want to order from the bar or waitress you only have 13 beer options total. I see what they were trying to do but didn't quite enjoy the experience.
I enjoyed Bay Street Biergarten's beer selection but have to agree with the others that the prepaid card is a scam. Watch out for the free pour, the get you by charging you for half of a glass of head each time a keg is changed. I paid 60$ for a card and was denied my Bombay Sapphire gin martini at the bar, which is unacceptable. And also, what's the deal with the community tables and the fact that one person has to pick up the whole tab? That's not how a community table operates. I like how the poster 'easydoesit' gives the restaurant 5 stars in order to bash a fellow reviewer. That smells of an inside job. Hilarious! In other news, the beef jerky was great!
I agree with the previous commenter about the prepaid cards. For such a vast selection of beer, why am I only limited to 13 options when there is probably 100 other drinks they can make behind the bar. If I'm going to pay you $40 without having a single drink, I'd appreciate you giving me a heads up next time.
Best Gullah food around. All the rice dishes are great, especially the gullah rice. Fried chicken almost as good as my mommas.
How can you review a place if you didn't eat there, didn't mention the beer/cocktails and your only criticism is that you can't use the prepaid car at the bar?
Get a life.
I used to frequent the Boat House in this location and have been to Bay Street one time. I chose a Thursday night that was roughly 2 weeks after opening. It was to capacity at 930p, one in, one out. The inside is very nice, they did a great job with the existing space and built an amazing outdoor patio. I didn't get a chance to order any food this time so i can't speak to that.
I think the pre-paid cards/tap-wall is a novelty that will soon fade. The deal-breaker for me is the fact that I cannot use my prepaid card at the bar. I intend to go back for a food sampling.
Bear Down! In town for business, this Chicago style sports bar is a must see!
Wonderful space for an event. Went to a Guerrilla Cuisine dinner there a couple of weeks ago and was surprised at how pretty the distillery hardware looks with the right lighting and how warm and comfortable the space was - especially for a warehouse and work site, at that (the bathrooms are a literally shining example). A few strategically placed pieces of art (big works well) and beautifully set tables were all that was needed to transform what would be a cavernous area in the back into a really cool, even elegant, venue. I know others worked hard to make that transformation and I WAS under the influence of some fabulous food, but the end result of GC & others' efforts highlighted the possibilities of the distillery space itself. The Striped Pig people proved very hospitable folks, dedicated to their craft and eager to share the process & results with willing fans. Sampled some powerful but oddly delicious moonshine & a more finished product. It is obvious that a great deal of thought went into making this space a welcoming place to hang out, whether for an event or just a visit.
It' quite interesting how at midnight on November 6th your "hottest bartender" was down 300 votes yet still seemed to win. Good to know the winner of Charleston's hottest bartender is predetermined.


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Melanoma. EBSCO DynaMed website. Available at: https://dynamed.ebscohost.com/about/about-us . Updated April 3, 2013. Accessed April 8, 2013.
Melanoma risk factors. Melanoma Research Foundation website. Available at: http://www.melanoma.org/learn-more/melanoma-101/melanoma-risk-factors . Accessed April 8, 2013.
Melanoma skin cancer. American Cancer Society website. Available at: http://www.cancer.org/acs/groups/cid/documents/webcontent/003120-pdf.pdf . Updated January 17, 2013. Accessed April 8, 2013.
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An online journal about visual art, the urban landscape and design. Mary Louise Schumacher, the Journal Sentinel's art and architecture critic, leads the discussion and a community of writers contribute to the dialogue.
New art at DeLind
This message just hit my inbox from Bill DeLind. Recovering from the flooded gallery space, he's added art to his end-of-the-year exhibit/sale. Here's his message:
A Happy, if Damp, New Year!
If you haven't heard, a pipe burst in the Monroe Building on the morning of December 23rd, dumping hundreds of gallons of water into my gallery and storage vault below. Instead of wrapping presents, I found myself moving over 300 pieces to higher, or at least drier, ground…not the way I planned to spend the holidays!
For details, you can turn to Mary Louise Schumacher's Journal Sentinel article.
Thanks to the many quick hands and clear heads of some dedicated volunteers, this was not the disaster it could have been; while we are still assessing the situation, it appears that most of the artwork escaped serious damage.
The Inventory Reduction Sale continues, with about 100 artworks added in the last two weeks. We have included a rare signed Kathe Kollwitz etching and aquatint, a Jacque Villon etching, several beautiful Louis Fortuney pastel drawings, Karen Rossi mobile sculptures and so much more. You can wait for Gallery Night, Friday, January 16th, but you might want to come in sooner to take advantage of the 20% to 80% savings. Yes, you read that correctly…we are serious about this sale!
Please pass (this news along) to any interested friends, and may you have an art-ful 2009!
Thank you,
Bill DeLind
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Posted 22 August 2006
Return to Discussion Text
Live Discussion led by Bruce Kagan on 2 May 2005.
Participants: Tom Fagan, Alzforum; Bruce Kagan, UCLA Neuropsychiatric Institute; David Corbin, New York; Wonmuk Hwang, Texas A&M University; Nico Stanculescu, Alzforum; Charlie Glabe University of California, Irvine; Larry Nault, Matrix Integrated Linkage LLC; Ratnesh Lal, University of California at Santa Barbara; Dave Teplow, University of California, Los Angeles; Ben Albensi University of Manitoba; Rose Xiao, Memory Pharmaceutical; Yuri Sokolov, University of California, Irvine; Ryan Lee, W3C/MIT CSAIL.
Note: The transcript has been edited for clarity and accuracy. _________________________________________________________________________
Tom Fagan Hi, Bruce! Hi, Charlie!
Bruce Kagan Hi, Tom!
Tom Fagan Okay, if you didn't guess by the microphone icon, I'm Tom Fagan and I'll be moderating today when necessary. Bruce is going to start us off with a brief introduction and then let the fun begin. Take it away, Bruce!
Bruce Kagan In 1993, Arispe et al.,1993 reported that Aβ formed ion channels, and proposed that channels could cause cellular pathology and toxicity. Abundant evidence now supports this view, including the facts that virtually all amyloids form channels and that Aβ can inhibit LTP, or long-term potentiation (see ARF related news story), depolarize neurons, allow cytochrome c efflux from mitochondria (see Kim et al., 2002), and kill cells. Channel formation readily explains most amyloid pathophysiology, including memory disturbance, calcium dysfunction, membrane depolarizations, increased reactive oxygen species (ROS), sensitivity to toxins, and apoptosis.
Larry Nault Bruce, do these channels have a hypothetical geometry. A pipe or a duct? Bounded by what?
Bruce Kagan Larry, Arispe and Guy proposed several possible models for the pore. Recently, Arispe has published evidence that specific regions of the peptide seem to line the pore (see Arispe, 2004).
Tom Fagan Bruce, how many channels does it take to kill a cell?
Bruce Kagan Tom, it depends on the size of the cell. The Aβ channels are large, electrically, and would create a significant leak. A single pore could reduce the sodium (Na+) concentration by about 10 micromolar per second.
Tom Fagan Bruce, how does that compare to normal leakage?
Bruce Kagan Tom, it again depends on the cell. For a neuron, which must maintain a tight membrane for signaling, a single pore would pose a significant but not lethal leak.
Wonmuk Hwang How specific are these channels? I understand that they have a distribution of sizes, which likely cause them to be nonspecific.
Bruce Kagan Won, the channels have been described as permeable to a variety of cations including sodium and calcium. There is little selectivity amongst cations.
Tom Fagan This fits in with what Charlie reported recently, right Charlie?
Charlie Glabe We see fluorescent dyes that are about 600 Daltons (Da) leaking; it is not ion-specific (see ARF related news story).
Tom Fagan Charlie, 600 Da is pretty big; do you mean such molecules are getting through these pores?
Charlie Glabe Yes, going both ways; I'm not sure of the mechanism. Large proteins like lactate dehydrogenase (LDH) do not leak detectably.
Bruce Kagan Charlie, we see non-electrolyte leakage of sugars with a diameter up to about 10-12 angstroms. Of course, we should temper this with the observation that we see many species of channels and they may all have different sizes and selectivities.
Tom Fagan Bruce, so are these channels in a state of flux? Can their size change dynamically with time, and might there be large and small coexisting in the same cell?
Bruce Kagan Tom, Charlie sees a very different result from ours, but Joseph Kourie has described at least three different Aβ channels with varying kinetics, selectivity lifetime, and so on (see Kourie et al., 2002).
Tom Fagan Everyone, any ideas on how these channels can be stoppered? Would this be a therapeutic strategy?
Charlie Glabe We haven't seen any known channel blockers that inhibit the permeabilization; but that doesn't mean that there aren't any.
Bruce Kagan Tom, the only blockers we have so far are very nonspecific, such as zinc (Zn2+) or tromethamine ions (e.g., Tris buffer). The development of more specific blockers could prove useful as a therapeutic strategy. Zn2+ does block the toxicity of Aβ on fibroblasts (see Zhu et al., 2000).
Wonmuk Hwang About Charlie's reply: How about the oligomer-specific antibodies that you published? Don't they block permeabilization?
Charlie Glabe Won, not known, but that is a reasonable hypothesis. We find that you need to start with oligomers first. I'm not sure that they insert into the hydrocarbon region in a traditional fashion, either.
Ratnesh Lal Calcium uptake has been blocked specifically by anti-amyloid antibody and zinc in both liposomes and cells (Rhee et al., 1998; Lin et al., 1999; Lin et al., 2001; Bhatia et al., 2000).
Tom Fagan So how does the channel hypothesis fit with the slow progression of the disease? Given the degree of leakage, it would seem that channels would be pretty lethal and that the disease should progress more rapidly, or am I being too simplistic?
Charlie Glabe Maybe a small leak just contributes to chronic stress as the cell has to pump more to keep up with the leak.
Bruce Kagan Tom, Dennis Selkoe's group has shown that oligomers can impair memory in a reversible fashion. Since we know Aβ channels can inhibit long-term potentiation (LTP), this might be the first step in the pathology (see ARF related news story and ARF news story; also Wang et al., 2002).
Tom Fagan Bruce, but in the LTP experiments, basal transmission is okay, which seems odd, given the degree of leakage you could get. I wonder if there is something modulating the channels?
Bruce Kagan Tom, the LTP experiments require very small doses (less than toxic) of Aβ. I suspect that they are altering membrane potential in a subtle way to inhibit LTP, but not enough to derail normal transmission.
Tom Fagan Ah! Possibly.
Wonmuk Hwang About channel formation: Is it known whether they are formed in solution, then incorporated into the cell membrane, or is it more likely that channels are formed through interaction with the membrane or the substrate (in case of in vitro experiments)?
Ratnesh Lal Evidence is published suggesting that both preformed oligomers can insert in the membrane or monomers can insert and oligomerize to form ion channels.
Bruce Kagan Won, there is clear evidence that the presence of lipids or membranes affects the folding of Aβ and other amyloids, tending to promote β-sheet and oligomerization (see, e.g., ARF related news story on lipid rafts and ARF news story on the effects of lipid anchors on prion amyloid formation).
Wonmuk Hwang Bruce, that is consistent with the finding that fibrils form in partially denaturing conditions—possibly the hydrophobic environment of the lipid tails enhances the condition for fibril formation.
Charlie Glabe We find that monomers are pretty inert. It isn't necessarily easy to make pure monomers.
Bruce Kagan Charlie, we find that monomers are inert also, but that with time in aqueous solution, oligomers form and insert into the membrane.
Ratnesh Lal As mentioned above, there is published work showing that monomers can induce cell toxicity as well as calcium uptake in both cells and liposomes.
Charlie Glabe Ratnesh, how were they sure they were monomers? They may start out that way, but things change pretty rapidly even in the absence of membranes.
Bruce Kagan Ratnesh, how can you be certain that the peptide remains as a monomer throughout the experiment?
Ratnesh Lal I don't think they remain monomers throughout the experiments. Instead, they do oligomerize. We have imaged those monomers in real time using atomic force microscopy (AFM). We have shown that for an extended period of time, in physiological buffer and in physiologically relevant concentration, they do not form oligomers. Nevertheless, as I mentioned above, monomers will oligomerize once in the association with lipids in the bilayer/liposomes.
Bruce Kagan Ratnesh, so that would be consistent with all the recent work suggesting toxicity of oligomers?
Ratnesh Lal Yes, that is all we have published in the last 7 years.
Wonmuk Hwang Ratnesh, I think that Aβ peptides are produced throughout the lifespan.
Ratnesh Lal Membrane-induced conversion from inert to an active form will be consistent with the expected conformational change in many amyloids associated with misfolding diseases. Won, I agree with you and have made that point in our earlier publications. Aβ peptides are produced throughout the lifespan and in many, if not all cell types.
Ben Albensi All, so is it just the induction of LTP that is affected or later stages, as well?
Bruce Kagan Ben, I believe it is just the induction, but I could be mistaken. Dave, do you know?
Tom Fagan All, how many monomers does it take to form the simplest channel—in theory even, if there is no experimental data?
Ratnesh Lal Tom, a model presented by Durrel et al.,1994 suggests that it can be anywhere from tetramer to octamer and more (perhaps up to 12).
Tom Fagan Ratnesh, is a tetramer big enough to form a pore and span the membrane?
Bruce Kagan Tom, Aβ42 tends to form hexamers, and those would be excellent candidates for the smallest channels.
Charlie Glabe It isn't clear that it has to span the bilayer in the traditional sense. How do you explain the fact that polyQ permeabilizes membranes in the same fashion?
Tom Fagan Charlie, I don't know. Any ideas?
Charlie Glabe Maybe the same reason that highly charged, polar peptides like HIV tat and Antennapedia can cross the bilayer with large passenger molecules attached to them? (See review on cell penetrating peptides).
Tom Fagan Charlie, are you suggesting we abandon "the channel" hypothesis and call it something else?
Charlie Glabe I don't know; this is something we are still trying to sort out.
Ratnesh Lal There is a model by Mobley et al. suggesting that monomers may or may not span the whole membrane. If they do not, it can still form an ion channel (like porins or others); otherwise, one would need an additional four monomers from the other membrane leaflet (and in that case it would be eight monomers total), or six or more, depending upon whether they form tetrameric, pentameric, hexameric, or higher order oligomeric channels.
Bruce Kagan Charlie, the polyQ story is striking in that there is a minimum length for pathology, yet this minimum varies from illness to illness. For Aβ peptides, we have shown that the minimum length to obtain channels is nine residues, which would span the hydrophobic core of the bilayer in β-sheet form.
Wonmuk Hwang How about the pure dimensional argument? The hydrophobic region of a lipid bilayer is about 3 nm, and if the channel diameter is about 2 nm, the oligomer channel must have about 36 nm^2. Given the size of Aβ, we can guess how many monomers are needed to span a bilayer like a channel. But as suggested above, even if the oligomers occupy only one leaflet, it is still possible for there to be a hole, through fluctuation of the lipids. In this case, the hole will be highly dynamic rather than statically open.
Ratnesh Lal Won, the pore diameter of 2 nm is quite big for any channel. The outer diameter of the oligomeric channel diameter would be consistent with what we had published earlier (see Lin et al., 2001). The inner (pore) diameter will be considerably smaller (~1-1.5 nanometer).
Wonmuk Hwang Ratnesh, I was referring to Hilal, Lansbury and colleagues' work on torroids—their electron microscopy (EM) images suggest that the inner diameter is about 2 to 3 nm (see, e.g., Rochet et al., 2004).
Ratnesh Lal Won, Lashuel's work is done on annular pores; peptides were never associated with any membrane (either before or after). For their actual channel conformation, they refer to our work (Lin et al., 2001).
Charlie Glabe If peptides that do span the bilayers are extended β structures, you would expect that they would have to form H bonded β barrels, which typically have ~20 strands.
Bruce Kagan Charlie's point is well-taken. This would predict very large channels indeed.
Dave Teplow Caution to all—there is a distinct possibility that Hilal's work, while relevant in in vitro systems, is not representative of what occurs in vivo.
Tom Fagan Charlie, I was just going to ask about molecular models that would have a pore. If the pore idea is correct, then wouldn't it be possible to estimate how many monomers would be needed, and how would that fit with current ideas on trimers, dodecamers, etc., that seem most toxic?
Charlie Glabe Uli Aebi tried to visualize pores or channels by AFM using preparations and conditions that caused dye leakage, and he did not observe "donuts." Instead, he saw defects in the membrane radiating from the oligomers (see Green et al., 2004).
Ratnesh Lal Charlie, there is a serious difference between Aebi's work and other channel work. In his work, amyloid was added to membranes that were preformed and adsorbed on a substrate, a common practice for AFM work. On the contrary, when you reconstitute in liposome or bilayer and then image with AFM, you do see channels (Lin et al., 2001).
Wonmuk Hwang In relation to Tom's question, what is the shortest length of a model peptide tried that forms channels?
Bruce Kagan There is a report of an Aβ31-35 fragment forming channels. I don't know what to make of this unless there is one peptide in each leaflet of the bilayer (see also Le and Qiao on Aβ31-35 effects on LTP).
Tom Fagan Charlie, Bruce, have either of you examined the effect of different lipids on leakage? Sorry, I'm not remembering the data off the top of my head.
Charlie Glabe Yes, not much specificity. Yuri can jump in on this if I have misspoken.
Bruce Kagan Tom, cholesterol inhibits. Negatively charged lipids are required for activity. Not much other specificity.
Ratnesh Lal There are some publications from the Arispe group on the effect of cholesterol on amyloid insertion and channel activity (see Arispe and Doh, 2002).
Bruce Kagan Charlie and Yuri, does membrane fluidity affect your results?
Yuri Sokolov Bruce, we did not study the effect of membrane fluidity. But recently we found very strong lipid-dependence of amyloid-induced conductance in bilayers.
Tom Fagan So what about other channels besides Aβ ones? What have we learned from those? Do they clarify anything or just make things more confusing?
Bruce Kagan I am struck by how similar the channels are that we see from a variety of unrelated peptides. Their physiologic properties are nearly identical. They are all "leakage" channels.
Charlie Glabe I second that. All amyloids are pretty similar.
Larry Nault Must close out. Interesting hypothesis. Clearance of building channel blocks may be the key to defeat of progression. Building channels over time and diving then through the bilayer is a process that might be interrupted with agents like zinc or by clearing essential oligomer building blocks.
Ratnesh Lal There is published work on many other amyloid proteins showing channel-like activity (Kagan's lab, Arispe's lab, Kourie's lab) and we have structural data from AFM study to confirm channel-like structures.
Tom Fagan Ratnesh, what do you mean by "channel-like."
Ratnesh Lal Tom, as the AFM work is purely structural and we do not do electrical recording simultaneously (I mean not on the same structures because we don't have an appropriate recording system), we take a conservative view that it is channel-like. However, in parallel studies on the same batch of specimen, electrical recording shows channel activity.
Bruce Kagan Tom, in the case of our work and that of Arispe and Kourie, these are clearly channels by all the standard criteria. Charlie's work clearly shows permeability without "channels."
Tom Fagan Ratnesh, I thought you were referring to a channel-like structure rather than activity.
Ratnesh Lal Tom, we do both: image the three-dimensional structure and in parallel do electrical recording. We are hoping to do both together someday soon.
Tom Fagan Great, Ratnesh; keep us posted!
Ratnesh Lal Thanks, Tom. We will be in touch.
Bruce Kagan Tom, one thing we have learned from complement and toxin studies is that "holes" that one sees in EM do not always correspond to the electrical pore pathways.
Tom Fagan All, we are nearing the end of our hour, but we can keep chatting as long as we like. But before folks start rushing off, I just want to thank you all for coming, and Bruce for agreeing to host this chat.
Wonmuk Hwang Is there any evidence that the channel-like structure must have torroidal morphology? How about spheroids? And thanks to all for useful conversations.
Tom Fagan So before we go, what are the crucial experiments that need to be done to advance our understanding of what is going on? Anyone, everyone?
Bruce Kagan I think there are two crucial experiments to be done. First, specific channel blockers need to be developed and tested in cell and animal models. Second, channels (or permeability changes) need to be found in animal models of disease.
Dave Teplow Bruce, are there any meta studies that could be done examining patients taking channel blockers for other diseases that would answer your question?
Bruce Kagan Dave, that's a great idea! However, for the easiest ones—the calcium channel blockers—we have already tried them without success.
Tom Fagan Bruce, tried them in vitro?
Bruce Kagan Tom, right, we tried them in vitro against our Aβ and other channels.
Tom Fagan All, we talked about channel blockers, but are there other strategies to stop the leakage of these "channels"? Also, are there synthetic channels that could be made to mimic the natural ones, and how might that be useful?
Ratnesh Lal Antibodies do block, and one can use peptides to block, as well (a practice useful in blocking gap junction ion channel activity).
Bruce Kagan Tom, yes, one could devise treatments that made the bilayer less susceptible to channel insertion. Arispe did this recently with robust effects on toxicity. He stiffened the cell membrane with cholesterol (see Arispe and Doh, 2002).
Yuri Sokolov Jim Hall and I found that an increase of bilayer thickness inhibits the effect of amyloid-β in bilayers.
Bruce Kagan Yuri, what's the latest on what ions and other molecules can go through your Aβ-treated membranes?
Yuri Sokolov Bruce, looks like everything we tested. HEPES, Tris, TEA....
Tom Fagan Yuri, you do this by using longer chain lipids?
Yuri Sokolov Tom, looks like with longer chains we have only preliminary data. But definitely the effect of amyloid-β is completely blocked by the saturation of bilayer with decane. We are not going to use decane as a treatment, but it is good enough to study the mechanism.
Tom Fagan Yuri, yes, for sure, anything that sheds some light on what's going on....
Bruce Kagan Tom, there are other ways to increase membrane thickness, such as changes in dietary lipids.
Tom Fagan Bruce, that's where I was headed. But you said that you tried different lipids and saw no specific effects, right?
Bruce Kagan Tom, yes we did try many lipids and didn't see major effects except of charge and stiffness, but we did not try to alter membrane thickness (one needs lipids with long tails). We should go back and do that. Good idea!
Tom Fagan Or you could use shorter ones to see if the problem is any worse.
Bruce Kagan Right. I know these manipulations to change lipid composition can be done in animals, but I don't know if they have ever been tried in humans. An interesting prospect! It is interesting to note that increased membrane thickness would inhibit standard channels as well as Yuri's permeability increase.
David Corbin Bruce, have you also considered the systemic effects in Alzheimer's of impaired calcium transport by fibroblasts (see Peterson et al., 1985)?
Bruce Kagan David, I'm not familiar with this paper. Do you think it might be evidence of Aβ channels in the fibroblasts?
Ratnesh Lal At least in in vitro studies, we have shown Aβ-channel-mediated toxicity in fibroblasts (Zhu et al., 2000).
David Corbin Bruce, I do not know. I was just looking at some of the early research on cell membrane abnormality in Alzheimer's to see what others have observed, such as decreased microviscosity.
Bruce Kagan David, I'm going to look up that paper. Thanks for bringing it to my attention. Goodbye to all.
Tom Fagan Okay, I think we should probably wrap up. Thanks, Bruce, most interesting. Thanks to everyone for joining in; I hope it was useful.
Nico Stanculescu Thanks, Bruce, and thanks, Tom!
Bruce Kagan Nico and Tom, thanks so much. I enjoyed this immensely!
Ratnesh Lal Thanks all!
Nico Stanculescu Splendid! We will be forwarding the transcript for review!
David Corbin Thank you.


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14154 results for "henry abbott"
Henry Abbott
Different ways to get a stop
Henry Abbott...
Blog | December 12, 2013 -
25 under 25
Henry AbbottKawhi Leonard was a candidate for Finals MVP, and he's only 14th on the list of elite young NBA players compiled by ESPN Insiders David Thorpe, Kevin Pelton and Amin Elhassan. That means a lot of things, including that good times are ahead for the NB...
Blog | December 11, 2013 -
Surprisingly productive defenders
Henry AbbottBrian Spurlock/USA TODAY SportsRoy Hibbert isn't the only reason the Pacers have the NBA's best defense. A tricky thing about basketball is that it's tough to know what's happening on defense. So tough that credit and blame are almost impossible to ...
Blog | December 11, 2013 -
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Year-Round Tanking
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Supernatural San Antonio
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Statistics For All
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The all-time record that almost wasn't
Henry AbbottAtlanta's Kyle Korver set a record by making a 3 in 90 consecutive NBA games -- and it never would have happened without a mid-game text message from an assistant coach's wife to her husband on the bench....
Blog | December 09, 2013 -
Ty Lawson on the attack
Henry Abbott...
Blog | December 06, 2013 -
TrueHoop TV Live
Discuss all the latest NBA on-goings with the TrueHoop TV Live team of Henry Abbott, Amin Elhassan, Tom Haberstroh and Ethan Sherwood Strauss at 1:30 p.m. ET....
Blog | December 06, 2013 -
Audio results for "henry abbott"
Clippers Podcast: 8/22
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Spanning the Globe: 7/8
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Henry Abbott, NBA
July 01, 2013 -
SVP & Russillo 7/1 - Full Show
July 01, 2013
How the Knicks and Nets are failing
Henry AbbottBy shooting from the hip in making key decisions, Amin Elhassan says the Knicks and Nets sowed the seeds of their own demise. ...
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Middling Portland
Henry AbbottAre the Blazers for real? Despite the hot start, Amin Elhassan projects the 15-3 Blazers to be a borderline playoff team in the crowded West. And: the revenge of the mid-range....
Blog | December 04, 2013 -
TrueHoop TV: Big Rookie Finds
Henry AbbottIt's hard to find a productive NBA big man. But the Celtics, Thunder and Nets pulled it off, with unheralded rookies Vitor Faverani, Steven Adams and Mason Plumlee playing well. David Thorpe on big men most of the league missed....
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Houston, we don't have a problem
Henry AbbottDon't look now, says David Thorpe, but the Rockets are good. Also, on the West being so much better than the East....
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Re-ranking the 2012 draft
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Bulls among the tankers?
Henry AbbottThe most successful tank job in NBA history came when an excellent Spurs team took advantage of David Robinson's injury to nab Tim Duncan. With Derrick Rose out, Chad Ford points out in his Tank Rank column that the Bulls have a similar opportunity....
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Craft Cycle Clothing & Base Layers Craft of Sweden is revered as a maker of some of the world's most researched, tested and high performing bicycle apparel. The Swedish brand operates at the very highest level of cycling by integrating Pro Team Rider feedback into each and every product. A cyclist can choose from the Craft Base Layer range, then for outerwear, the Active, Performance or Elite collections; tailoring their choices to how often they ride, or that meet their individual requirements.
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Saint Gerbold of Bayeux
Also known as
- Gereboldus
Benedictine monk at Ebriciacum (in modern France). Founder and abbot of the abbey of Livray, France. Bishop of Bayeux, France.
Additional Information
- Book of Saints, by the Monks of Ramsgate
- Our Sunday Visitor's Encyclopedia of Saints
MLA Citation
- "Saint Gerbold". Saints.SQPN.com. 5 December 2012. Web. 5 December 2013. <http://saints.sqpn.com/saint-gerbold/>


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Brooklyn Brine Whiskey Sour Pickles are made with McKenzie Rye Whiskey in small batches and packaged by hand. Learn More
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Sweet and salty, Early Bird Haulin' Oats is a great choice for an on-the-go energy boost. Learn More
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Made with tomatillos and three kinds of peppers, this green chile sauce from Bunches & Bunches Provisions offers an authentic taste of Mexico. Learn More
Bunches & Bunches Provisions Red Dried Chilaca Mole Sauce will spice up any meal with an authentic taste of Mexico. Learn More


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CHRISTMAS TIME - Embroidery Patterns
Jing-jing-jing-a-ling! Since my Winterland sheet sells year-round I figured that it was time for even more holiday motifs for your stitching. Merry Christmas to all and to all an embroidered gift!
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Choose iron-on transfer, downloadable PDF with COLOR Guides, or combo of both for a special price! (Want to know the difference?)


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Wake up every weekday morning with Denver's favorite morning show! The Dom and Jane Show, a staple in the Mile High City for more than a decade, gets you going with laughter, interesting talk, and music.
Jane keeps you up to date with her own dish on Hollywood's antics, while Dom blows your mind with The Mindbender, the most popular radio contest in the world! Plus, Dom, Jane, Jeremy and Emily share hilarious experiences from their own lives, often of the embarrassing variety.
If you'd like to join in the fun, be sure to sign up for Live Audience Friday, the only live audience radio show in the world. You'll get to hang out in the studio and actually be a part of the show!
So tune in every weekday morning, either on your radio, your computer, or your smartphone! The Dom and Jane Show! Email Dom and Jane: Feedback at Dom and Jane dot com
Add The Dom and Jane Show blog updates to your iGoogle homepage - click here:
You know you'll never look at the zillions of pictures you've taken with your phone. And now we find out that all of those pictures are affecting your ability to store memories. Uh oh...
Also, did you know there are things that actually influence your dreams? I've got details for you. And watch out, a certain style of voice inflection is spreading out of California . . . and it might drive you nuts. Plus, your video treat this week is out of this world. Literally. Check it all out in this week's News For Nerds, right here. It's time to get your nerd on!
A lot of weight gain in this country is attributed to something called "stress eating." So what if we had a device that could measure that - and help to prevent it? Well, maybe we do. Ladies, it could be your bra. I've got details in this week's News For Nerds.
Also, wanna know how to make yourself look more attractive in a photograph? I can tell you if you click the link. And, as a bonus, I have a pee chart. Yes, a pee chart. You'll want to see it, because your pee is a window into your health. Oh, yes it is. Plus, your fun video this week involves water running uphill. Science is cool. Check out all of these stories right here, with one little click, and enjoy! .
•If you pass an open spot, you cannot 'back-up' to get it. Once it's passed, it's a free spot again.
We've always thought that a quiet, relaxing weekend was the best thing for us. Well, not so. In fact, the more you can do on a weekend, the better. At least as far as your brain (and your attitude) is concerned. I have details this week in the link. And you might've heard about sleep apnea, but it's possible that you suffer from Email Apnea. In fact, I think it just happened to me while I was typing this . . . Plus, high school students build an actual satellite, and a new animated video explains the mystery behind "silent but deadly" flatulence. (See, not everything on News For Nerds is highbrow.) All of this is waiting for you right here, so I hope you enjoy and share. And thanks for getting your nerd on with me! Dom .


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Never a company to be behind the cutting edge, Marshall's two newest lower-powered amplifiers are all-tube little monsters that have been designed to satiate fans of the current trend toward "smaller is better"—or rather, the demand for lower wattage tube amps that can roar with the best of them at a reasonable volume. To boot, Marshall's new Haze Series—with a 15-watt mini stack and 40-watt combo as its inaugural members— come complete with built-in effects. The look of the new Haze 40 shares a lot in common with JMP combos of yesteryear. The salt-and-pepper grille cloth is classy, and is set off quite well by the smaller dimensions of the amplifier. It utilizes a pair of EL34 tubes for power, and a specially-voiced Celestion G12T- 66 12" speaker strapped into a closed-back enclosure with four portholes in the lower portion of the rear panel. Its two channels share a common three-band EQ section, each with its own dedicated switchable volume boost. It also has a Presence control, which the Haze 15 head lacks. Figuring that players would like to spice up their experience with a few effects, Marshall also
included three different built-in effects, which are selectable from a momentary button on the faceplate. These are: Echo, Chorus and Vibrato. Each can be adjusted with the Effect Depth and Adjust controls, which are located next to the Reverb Level knob.
Plugging In
With a name like Marshall on the grille cloth, I figured a good Les Paul would be the right tool for this job. I used a 1978 Gibson Les Paul Custom with Tom Anderson pickups to put the amp through its paces. Starting with a basic clean (and all of the tone knobs at noon) and just a hint of reverb, the Haze 40 produced a great clean tone right off of the bat. It's not that I had any doubt it would sound good, but I was startled at how easy it was to achieve a great shimmering tone. Some more tweaking and a 2008 Fender American Stratocaster helped even more. The amp has a generous bass response (probably due to the closed-back construction), so I had to be careful not to go overboard with that control. The portholes, which are a common design addition in bass cabinets, give
the Haze combo an extended bass response, allowing the tone a wider, more focused low end instead of a boomy one. For such a small combo, the Haze 40 had an unexpectedly three-dimensional feel to it, especially with the boost engaged. The boost raised the volume, of course, but it also caused all of the right frequencies to shine through without any sort of ice-pick highs (or the dreaded "jump out of the chair" effect).
Since a good clean tone is essential to testing effects, I left the Haze still set in this glistening, transparent clean to give the built-in ones a listen to hear how detailed and useful they could be. Easily the most impressive was the Echo effect. I've always liked Marshall's delay pedals (I think they're highly underrated), and the Haze's Echo effect shares a lot of the common traits of those effects; smooth top end, clear but not harsh repeats and great decay. The Vibe effect performed admirably well, but had a very digital edge to it. It's certainly usable, but no replacement for a good dedicated pedal. Lastly, I found that the Chorus is a little too shallow for me.


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The latest news on liberals
The group Americans United for Change got crafty.
Major OB/GYN group opposes provisions requiring abortions be at surgical centers.
Libertarians and liberals on the same side when it comes to privacy issues.
Activists threaten to mount primary challenges to Democrats who support cuts.
Liberals Like Cougar Town, GOP The Bachelor
On left, lawmakers worry that super committee Democrats are giving up too much.
From New York and Washington elites to speculators in Los Angeles, the Great Recession had many fathers.
Simpson-Bowles charts a smart, fair path toward controlling government spending while preserving the social safety net
New research finds that liberals may owe their political outlook partly to their genetic make-up.
You can argue that this economic crisis began under the Bush administration, but this non-recovery belongs completely to the Obama administration.


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Mr Vegas - Party Tun Up / Whine Up [Dancehall Reggae]
Description: Dancers roll out and buss a whine with MR VEGAS on his smash hit
"Party Tun Up." The video was shot on location in Jamaica and New York
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Total Views : 174,814 Video Added : 2013-02-28 Video Code:
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text:
PHILADELPHIA (AP) — A New Jersey man is facing charges after police say he intentionally vomited on an 11-year-old girl and her father in the stands during a Phillies game.
Twenty-one-year-old Matthew Clemmens, of Cherry Hill, N.J., was arraigned Friday on charges stemming from his behavior at Wednesday night's Phillies-Nationals game.
Police say Clemmens made himself vomit on an off-duty police captain and his daughter after a companion was kicked out for unruly behavior.
Easton police Capt. Michael Vangelo says he saw Clemmens put his fingers down his throat. Philadelphia police say Clemmens also punched Vangelo and vomited on an arresting officer.
Clemmens is in custody on charges including assault and harassment. Bail is $12,000. His listed phone number is disconnected.
Copyright 2010 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Barrington Broadcasting is a member of the AP Network.


text:
Online learning
iCampus Student Competition yields online tools for improved on campus experiences
May 21, 2013
Grand prize in 2013 competition goes to an online exploration tool to aid students in planning their selection of classes.
EdX expands xConsortium to Asia and doubles in size with addition of 15 new global institutions
May 21, 2013
EdX continues to grow its network of the world's leading institutions of higher education to meet global demand and increase access to quality education.
Also labeled: Educational Innovation and Technology, EdX, Global, Massive open online courses (MOOCs), MITx
Sal Khan: 'I love learning'
May 9, 2013
At MIT, alumnus describes his path to reshaping education through highly accessible online videos.
Lawrence Bacow speaks on challenges facing higher education
May 2, 2013
Former MIT chancellor examines rising costs, digital learning in Charles L. Miller Lecture
An MIT physics MOOC five years in the making
May 1, 2013
Materials for the new MITx summer course Mechanics ReView have been refined during a half-decade of development
Also labeled: Education, teaching, academics, Massive open online courses (MOOCs), MITx, OpenCourseWare, Physics, EdX
6.003z signals a new open education ecosystem
April 29, 2013
MITx student used OCW to create his own massive open online course.
6.002x to be offered at up to 12 California State University campuses
April 10, 2013
The expanded collaboration between San Jose State University and edX follows a successful pilot that increased pass rates.
Stanford University to collaborate with edX on development of non-profit open-source edX platform
April 3, 2013
edX Learning Platform to be open source and available on June 1
A new wrinkle in online education
April 2, 2013
An experimental online course gives some students scheduling freedom.
With an educational 'revolution' afoot, Task Force on the Future of MIT Education to convene
April 2, 2013
Idea Bank to solicit community input.
OCW supports independent study for N.J. high school students
April 2, 2013
Wired New Jersey principal uses MIT OpenCourseWare to expand educational opportunities
Also labeled: Education, teaching, academics, OpenCourseWare
OCW provides challenges for talented young student
March 26, 2013
Indian teen Tuhin Bagi uses MIT OpenCourseWare to enhance his studies and set his sights on future endeavors.
Faculty describe experiments with digital learning on MacVicar Day
March 22, 2013
Participants discuss how they are 'reimagining the MIT classroom.'
Also labeled: Awards, honors and fellowships, Education, teaching, academics, Electrical engineering and electronics, Engineering Systems, Faculty, Foreign languages and literatures, History, Internet, MacVicar fellows, Massive open online courses (MOOCs), Mechanical engineering, Undergraduate, Special events and guest speakers
MITx version of introductory biology class has deep roots
March 18, 2013
7.00x brings an MIT classic online.
Higher-ed leaders meet to discuss future of online education
March 6, 2013
Innovative pedagogical techniques and the effects of online-learning tools on on-campus education subjects of conversation at MIT- and Harvard-led summit.
Six new institutions join edX
February 20, 2013
Consortium doubles its institutional membership with the addition of universities in Australia, Europe, Canada and the United States.
OCW brings educational opportunities to Sierra Leone
February 12, 2013
Student builds robot from old toy parts using course materials from 6.270.
Institute-Wide Task Force aims to sketch the MIT education of the future
February 6, 2013
Saying 'we are in the midst of an educational revolution,' President L. Rafael Reif asks Professor Sanjay Sarma and EVP and Treasurer Israel Ruiz to lead an effort to envision the MIT of 2020 and beyond.
Also labeled: Alumni/ae, Community, Education, teaching, academics, Educational Innovation and Technology, EdX, Faculty, Massive open online courses (MOOCs), MIT Administration, MITx, OpenCourseWare, President L. Rafael Reif, Residential life, Staff, Students, Institute-wide Task Force on the Future of MIT Education
Office of Digital Learning to host open house
February 4, 2013
Event to share opportunities and services from MITx, OEIT and OCW.
Duflo, Lander, Lewin to lead spring-semester MITx courses
January 31, 2013
EdX takes stock of last semester's MITx courses; data will be used to improve education online and in the classroom.
New online learning tool brings 'the crowd' into homework assignments
December 14, 2012
Also labeled: Computer Science and Artificial Intelligence Laboratory (CSAIL), Computer science and technology, Faculty, Graduate, postdoctoral, Graphical user interfaces, User interfaces, Education, teaching, academics, Graphical programming interfaces, Programming, Crowdsourcing, Social networks, EdX, Students, Undergraduate, Software, Big data
Sanjay Sarma appointed as MIT's first director of digital learning
November 20, 2012
Mechanical engineering professor will shepherd efforts to integrate elements of online education into traditional MIT courses.
OEIT's role in fostering open education: an interview with Vijay Kumar
October 31, 2012
The director of MIT's Office of Educational Innovation and Technology discusses OEIT's role.
MIT OpenCourseWare marks 10th anniversary of pilot site launch
October 5, 2012
The first materials from 32 courses were published in a pilot site launched 10 years ago last month.
Innovation in the classroom
September 21, 2012
'Future of Education' symposium, held before the inauguration of President L. Rafael Reif, examines the evolution of teaching and learning.
Also labeled: Alumni/ae, Education, teaching, academics, EdX, Faculty, Global Education and Career Development, Inauguration, Innovation and Entrepreneurship (I&E), Global, Massive open online courses (MOOCs), MITx, Open Learning Enterprise, OpenCourseWare, President L. Rafael Reif, Students, Educational Innovation and Technology, Singapore University of Technology and Design (SUTD), Undergraduate Research Opportunities Program (UROP), D-Lab
MIT's place in the world
September 20, 2012
Inaugural symposium addresses the Institute's global engagement.
Also labeled: Collaboration, Education, teaching, academics, Faculty, Global Education and Career Development, Globalization, Inauguration, Global, Masdar, President L. Rafael Reif, Singapore University of Technology and Design (SUTD), Skolkovo, Students, Electrical engineering and electronics, History, Linguistics, OpenCourseWare, Philosophy, Staff, Undergraduate, Abdul Latif Jameel Poverty Action Lab (J-PAL), MISTI, D-Lab
Fundamentals of Biology now available in OCW Scholar format
September 6, 2012
Course is the last of seven OCW has published this year specifically to meet the needs of independent learners.
UC Berkeley joins edX
July 24, 2012
UC Berkeley joins Harvard and MIT not-for-profit online-learning collaborative; edX broadens free course offerings into public health, computer science and solid-state chemistry; opens registration


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Guard your coin purses. Next-gen's Thief is coming to VGX.
Views: 8,647 | Posted: 12/05/2013
Are you ready for the future? Tune in to see the full World Premiere Trailer on Saturday, December 7th during VGX!
Views: 8,282 | Posted: 12/05/2013
Which Nintendo game was the cat's meow this year? Check out the full list of the nominees right now!
Views: 9,714 | Posted: 12/05/2013
Find out more about Tom Clancy's The Division and its Snowdrop Engine in the full trailer at the Spike VGX Saturday, Devember 7!
Views: 16,148 | Posted: 12/05/2013
Neverwinter gets its biggest content update with Shadowmantle. Check out what's in store!
Views: 3,266 | Posted: 12/05/2013
Allods Online's newest expansion Wind of Change is arriving today.
Views: 1,941 | Posted: 12/05/2013
Check out what the heart of the combat experience will be like in this story-driven single-player epic.
Views: 1,549 | Posted: 12/05/2013
Today's SMITE patch heralds the arrival of Chinese goddess Nu Wa, Protector of Heaven.
Views: 3,098 | Posted: 12/05/2013
War Thunder's Ground Forces Expansion rolls into beta. Find out more in this trailer!
Views: 3,405 | Posted: 12/05/2013
Killzone Shadow Fall developers discuss the game's story of people in conflict.
Views: 3,718 | Posted: 12/05/2013
NBA 2K14's My Career mode creates a cinematic experience for players.
Views: 5,003 | Posted: 12/05/2013
Ubisoft's high seas adventure is ready to set sail!
Views: 4,416 | Posted: 12/05/2013
Search for the Book of the Dead in this DLC expansion for Dark.
Views: 3,984 | Posted: 12/05/2013
Ashly Burch pays a visit to Volition works her way into a DLC update.
Views: 9,427 | Posted: 12/05/2013
Experience 12v12 free flight dogfighting in space in the new Free-to-Play Star Wars: The Old Republic expansion, Galactic Starfighter.
Views: 12,378 | Posted: 12/05/2013
New maps, modes and vehicles are abound in this montage from the PC version of Battlefield 4, freshly updated with the China Rising DLC.
Views: 19,210 | Posted: 12/04/2013
Get a breakdown of the Need for Speed Network from second screen to first in this trailer for the Rivals companion app.
Views: 3,081 | Posted: 12/04/2013
Check out The Broken Sword, an adventure game with a mystery older than the written word.
Views: 7,122 | Posted: 12/04/2013
Several big hitters released just before the dawn of Next-Gen, but which can claim to be the best on the Xbox 360 in 2013? See the contenders now!
Views: 28,644 | Posted: 12/04/2013
Killer Instinct is staging a comeback, but it's stuck in Round 1. Find out why in this special Launch Report.
Views: 55,031 | Posted: 12/04/2013
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The country I am doing is Belize. Belize celebrates Christmas by putting boats on their Christmas tree's these boats represent the amazing fishing industry. In Belize people celebrate by going to dances and dinners. Belize was adopted by a British colony they also do celebrate American holiday's. Boxing Day is the day after Christmas people dance and sing up and down the streets. People of many ages Waltz and Foxtrot at a Grand Ball on New Year's Eve. I have told you many of the ways that Belize celebrates the holiday called Christmas.
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BY LIZA STROUT - First, pictures and videos began to appear on Facebook. Dead tarpon, floating in the Pass after a Professional Tarpon Tournament Series event. A tarpon slowly dying, a circle hook snagged through its throat.
They spread through the local Facebook community and beyond like wildfire.
At the same time, a website appeared with little fanfare. It was an online petition to the sponsors of the PTTS, and a call to boycott those sponsors.
The roster of people who have signed the petition reads like a "Who's Who" of the scientific and angling world: Stu Apte, Hall of Fame angler; Dr. Jerry Ault, one of the most respected marine fisheries research scientists in the world; Ralph Delph, who holds the record for the most IGFA world fishing records and Lefty Kreh, a pioneer of salt water fly fishing and author of the seminal work "Fly Fishing in Salt Water."
And the list goes on.
When local author Randy Wayne White discovered the restaurant bearing the name of his best-known character was sponsoring a boat in the PTTS, he called for the removal of the wrap from the boat. It was too late to get their sponsorship money back, but White did not want his name associated with the tournament.
Usually considered an "island issue," this year the subject has been covered by papers from Charlotte County to Naples, with reports that there will soon be articles even further afield. Blog posts have been found reposted by anglers as far away as Colorado.
But what is the aim of Savethetarpon.com?
"My wife and I were looking for a way to stop what was going on," said Capt. Tom McLaughlin, one of the people who set up the web site. "I came from the Keys about five years ago, and in that time I've seen the downward progression of respect - for the tarpon, for each other and for the fishery as a whole. I've seen behavior by anglers in the Pass that wouldn't be allowed anywhere else."
So Capt. McLaughlin started calling around.
"I found out that there were really only two voices on the topic, the Fishing Guides Association and the PTTS," he explained. "But the more I talked to people, the more I realized that people who weren't part of either organization had something to say on the subject. So I decided to give them a voice."
It is not a voice against jig fishing. McLaughlin does not care what is on the end of the line.
"It's about behavior and the impact of that behavior," he said. "The hyperagressive culture of the PTTS is spreading beyond the event itself. For a long time, the people who came to fish in the Pass were people whose families had fished here for generations, or new people learning from the old-timers. These days, people see the PTTS on tv, and they think that that is what tarpon fishing is about. They don't understand that what they are seeing is just for ratings."
The way McLaughlin sees it, the PTTS is setting fishing in the Pass back by about 15 years.
"It took forever to get people to stop killing the tarpon," he said. "Even after they started releasing them, it still took a long time to get them to stop taking the fish out of the water for pictures. Now, when people see what happens in the PTTS, they think it's the way that things are supposed to go."
The Save the Tarpon web site, which McLaughlin is quick to point out is not an organization, but a forum for people to be heard, has so far received more than 500 electronic signatures.
"In reality, that represents far more people," said McLaughlin. "Each email address can only sign once, so families that share an address only count once, even though there may be more than one person using it. What is really interesting is that the people signing it aren't the same names you hear every year. They are people who have come here from all over the world, who have seen the PTTS in action. When they get home and do a little research, they realize that what they saw was not ethical angling. And that is what we want. We want word to spread to other areas."
According to McLaughlin, this is the last congregation area for the tarpon in North America.
"If this fishery is ruined, then tarpon fishing as we know it is destroyed," he said.
As of press time, Team Garmin and Team Andros had announced that their teams will no longer participate in the PTTS. The PTTS has not responded to a request for comment from the Boca Beacon.


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Will I Have to Replace My Server in Six Months
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Barcelona is one of those destinations that never ages. No really, with the Sagrada Familia still being built, it's always new! Spend your days exploring Gaudi's masterpieces or laying out on the beach and your nights strolling down Las Ramblas or eating tapas. Barcelona will never get old. | ||
Click here for great prices on tickets to Barcelona! |


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PORTSIDE July 2012, Week 3
The Rahmney Plan for Schools
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The Rahmney Plan for Schools Mitt's approach to education sounds a lot like Mayor Emanuel's " Yes, that's right - Republican Romney and Democrat Rahm are like two peas in a pod when it comes to public education. It's a little ironic given that Romney blames President Obama - Emanuel's former boss at the White House - for everything that's wrong with education today." By Ben Joravsky The Chicago Reader July 3, 2012 http://www.chicagoreader.com/chicago/romneys-plan-for-schools-sounds-like-rahms/Content?oid=6860548 In my role as the education guy at the Reader, I've dutifully read Mitt Romney's position paper on public education - a feat I doubt even Romney has accomplished. You can read it yourself, if you're up for the challenge. It's called "A Chance for Every Child" and it's only 30-some pages long, even with all the footnotes intended to make it seem like a scholarly dissertation as opposed to a salvo in a presidential campaign. Here's the big takeaway for Chicagoans: in many respects, it reads like it could have been written by our very own union- busting, charter-school-loving Mayor Rahm Emanuel. Yes, that's right - Republican Romney and Democrat Rahm are like two peas in a pod when it comes to public education. It's a little ironic given that Romney blames President Obama - Emanuel's former boss at the White House - for everything that's wrong with education today. Along with teachers' unions, of course. Let's take it one at a step at a time, starting with the charters, which Romney loves almost as much as the family dog - though I doubt he'd strap a charter school to the roof of the car, even if he could. "Charter schools are public schools of choice that are run independently and freed from many of the rules and regulations governing traditional school districts," says the Romney missive. "Thanks to a strong and growing bipartisan base of support, the charter movement is over 5,600 schools strong . . . . While the performance of individual charter schools in improving student achievement varies, the most successful among them are having dramatically positive effects while working with some of the nation's most disadvantaged students . . . . Under a Romney Administration, more funds will be allocated to grow the number of high-quality charter schools and create the conditions under which they can flourish." In Romney's defense, some of the things in that passage are true. Charters do have bipartisan support, though I'm not sure why. And they are growing like weeds - 110 in Chicago alone, with 60 more to be added by 2017. I assume that Romney will pump millions more into charters, if only because they're also backed by key Republican donors. But they don't score better than regular public schools staffed by unionized teachers. Quite the contrary: in Chicago and Illinois the highest-scoring schools are unionized, complete with negotiated contracts governing seniority, tenure, and hierarchical salaries. If you reduce the field to schools with low-income students who live in the surrounding neighborhoods, the scores are about the same - though you can't really do this, since charters take kids from everywhere. Hey, give the charters this: they're masters of PR. And, of course, they're generally nonunion shops. In Chicago, state law prohibits charters from being represented by the Chicago Teachers Union. I suspect that's their greatest appeal to a Republican like Romney. As he puts it, "America remains gridlocked in an antiquated system controlled to a disturbing degree by the unions representing teachers. The teachers unions spend millions of dollars to influence the debate in favor of the entrenched interests of adults, not the students our system should serve." Translation: Teachers' unions give to Democrats. Charter supporters give to both Democrats and Republicans, but mostly Republicans. Incidentally, like many other good Republicans, he's also a fan of voucher programs that use public money to send kids to private schools. Let's not kid ourselves - this debate has very little to do with education and a lot to do with politics. It's pretty obvious to me that Romney doesn't have a clue about how to address the great challenge of public education, which is eradicating the performance gaps between the highest- achieving schools, generally located in the wealthiest communities, and their lower-scoring counterparts in poorer communities. And who can blame him? That's the hard stuff. But he does know this: by beating the drum for charters and vouchers, he helps the cause of Republicans by undercutting the Democrats. It's good old-fashioned partisan politics, and hats off to him and the rest of the Republicans for playing it. My main question is this: why is Mayor Emanuel - a lifelong Democrat - joining in? Probably for the same reason on a local level. The less power the Chicago Teachers Union has, the more power the mayor has - as if he doesn't have enough already. As Mick Dumke and I noted in last week's cover story, Emanuel routinely meets with charter school advocates and funders - some of whom, like Kenneth Griffin, are also generous donors to the mayor's campaign. But he hasn't met with Chicago Teachers Union president Karen Lewis since August 2, 2011, according to Lewis. And that was the meeting where Emanuel lost his temper and yelled, "Fuck you, Lewis!" The mayor's defenders tell me he says "Fuck you" to everyone - though I personally doubt he drops it on Griffin or any of his other big-time donors. Moreover, John Kupper, the political consultant Emanuel often hires to write his speeches, helped lead the charge against the union's recent strike-authorization vote by producing commercials for an antiunion group called Democrats for Education Reform. The purpose was to fire up parents against the union in order to force teachers to vote against a strike authorization. It didn't work too well. Roughly 90 percent of the teachers voted to give Lewis the authorization to call for a strike should ongoing contract talks break down. Kupper is a partner at AKPD, a firm started by David Axelrod, who, as we all know, is President Obama's chief political strategist. So you have Axelrod's firm helping lead an antiunion campaign in the president's hometown while Romney assails Obama for being a tool of the unions. All of which makes about as much sense as our existing marijuana laws. I called Kupper to ask why he lent himself to antiunion cause. He didn't get back to me. But other Democratic strategists tell me there's a larger strategy at play here. Let's follow their logic: Obama is sensitive to Romney's charge that he's too beholden to unions because he fears the accusation will alienate voters in key swing states such as Virginia. So he's giving Emanuel the green light to beat the crap out of Chicago teachers in order to convince these swing voters that the president is fed up with unions too. Well, that's one theory, anyway. Look at it this way, teachers: by working longer for less and losing your tenure and watching while one school after another gets handed over to the charters, you're doing your part to help reelect President Obama. Not that Mayor Emanuel, his former chief of staff, will thank you. [Who is Ben Joravsky -- http://www.chicagoreader.com/chicago/ArticleArchives?author=847359 I moved to Chicago in 1981 and have been writing about local politics ever since. I started freelancing for the Reader in the early 1980s and became a full-time staff writer in 1990. Since 2003, I've zeroed in on larger citywide matters, with a special interest in exposing municipal financing scams, most notably Tax Increment Financing and the city's proposal to bring the Olympics to Chicago. I've also written dozens of profiles and features, including my year with the Roosevelt High School boys basketball team, which was included in the Best American Sports Writing Anthology. Over the last few years, Mick Dumke and I have collaborated on investigations exposing everything from the parking-meter- sale ripoff to our costly and unfairly enforced marijuana laws. I've written five books, including Hoop Dreams and The Greens, which I co-wrote with Rick Stone. I've won many journalism prizes, including the 2010 Chicago Journalist of the Year Award from the Chicago Journalists Association and the 2010 Illinois Journalist of the Year Award from Northern Illinois University. Last but not least, I also write for The Third City, a daily humor blog that "rarely lies to the American people." ] ========== ___________________________________________ Portside aims to provide material of interest to people on the left that will help them to interpret the world and to change it. Submit via email: [log in to unmask] Submit via the Web: http://portside.org/submittous3 Frequently asked questions: http://portside.org/faq Sub/Unsub: http://portside.org/subscribe-and-unsubscribe Search Portside archives: http://portside.org/archive Contribute to Portside: https://portside.org/donate
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The CSI New York team investigates when the recently paroled brother of a young basketball prodigy is implicated in a murder. watch
As if Stephen (Robbie Amell) and Cara (Peyton List) didn't have enough to contend with, there's a new baddie coming to town. Gangster Squad's James Landry Hebert is joining The Tomorrow People as The Wraith, a mysterious hitman who teleports past security and reads his victims minds, TVGuide.com has learned exclusively.
It didn't take long before The Tomorrow People brought Cara (Peyton List) and Stephen (Robbie Amell) together. The dynamic duo shared a steamy kiss — and eventually more — at the close of last week's episode, but don't expect a happy ending so soon. Cara will...read more
Peyton List discusses Cara's tactics for enlightening Stephen.
Madeleine Mantock talks about her character's relationship with Stephen in this interview.
Cheaper by the Dozen 2 -- Clip: Log roll
Cheaper by the Dozen 2 -- MovieMaze.de - Trailer (Quicktime)
more Robbie Amell Clips & Interviews videos
America's favorite movie family returns in Cheaper By The Dozen 2. Only this time, they're going toe-to-toe against another clan in the ultimate inter-family battle.
more Robbie Amell Movies videos
When John finds himself in a dangerous situation, Stephen is unable to help without revealing himself to Ultra. Also available on iTunes, Amazon Instant Video and VUDU
Stephen is determined to uncover what he hopes is the key to finding his father, and crafts a plan with the Tomorrow People that involves getting inside Jedikiah's head. Also available on CW, iTunes, Amazon Instant Video and VUDU
When Stephen decides to have some fun with his newfound powers, Jedikiah takes extreme measures to make sure it doesn't happen again. Also available on CW, iTunes, Xfinity, Amazon Instant Video and VUDU
When Stephen and Russell head out for a night of fun, they run into a potential new break-out. Stephen and Russell report back to John and Cara about the new person. Also available on iTunes, Amazon Instant Video and VUDU
more Robbie Amell On TV videos
more Robbie Amell credits (26 total credits)
In a dark world where a mysterious organization is hunting down and killing children with powers, Russell (Aaron Yoo) has been The Tomorrow People's bright spot. But we'll see a new side to the fun-loving jokester of the Tomorrow People when Aaron discovers that his father has died on Wednesday's episode (9/8c on The CW), which dredges up memories from his past that he's kept suppressed for years.
The CW orders full seasons of The Originals, The Tomorrow People and Reign
"As with a lot of comedians and funny people in general, humor is a coping mechanism to deal with a lot of pain," Yoo tells TVGuide.com. "Russell has a personal secret that... read more
Stephen forgot the first rule of Fight Club being a Tomorrow Person: Don't let anyone find out about your superpowers!
After helping to save one of his classmates a few weeks back on The Tomorrow People, Stephen (Robbie Amell) teleported away from the train tracks just when Astrid (Madeleine Mantock) drove up. But when she confronted him, he lied to her face, causing a rift between Stephen and his only human friend. Has Stephen's big secret been blown?
The Tomorrow People's Luke Mitchell on John's game-changing secret
"She thinks she knows, but... read more
Cara (Peyton List) isn't the only one running from her past. Tuesday's Tomorrow People reveals that John (Luke Mitchell) has more than a few dark secrets of his own — including one that could threaten his place among the Tomorrow People.
While a young John was initially happy with his place at Ultra, this week we'll learn the painful reason he couldn't continue playing good son to Jedikiah (Mark Pellegrino) any longer. "Jedikiah essentially experimented on [John] ... and the side effects of that and the effect that it's had on John's life have been pretty tumultuous," Mitchell tells TVGuide.com.
Can't they all just get along? Perish the thought.
Few spectacles are more exciting and satisfying than watching a great series reinvent itself with bold strokes and high drama. In its five seasons, CBS's The Good Wife has never played it safe in boardroom, courtroom or bedroom — but nothing could have prepared us for just how explosively entertaining the war within Lockhart/Gardner was going to be.
Aw, heck. Is it really worth making a fuss over The Middle's 100-episode milestone? It hardly seems in character for a family like the Hecks of Orson, Indiana. When she's reminded that they volunteered to drive a giant cow float in Orson's centennial parade, Frankie (Patricia Heaton) whines, "This is what happens when we drink: We sign up for stupid committees. Or get Brick."
But as Orson itself expresses in a self-deprecating new town motto: "Why not?" This episode (Wednesday, 8/7c, ABC) truly is cause for celebration, as TV's most heartfelt and hilariously relatable family sitcom reflects on what brought Frankie and Mike (Neil Flynn) to Orson in the first place, while giving their lovably imperfect offspring a chance to shine in clever-to-wacky subplots. (Sue's attempt to make Darrin jealous by cozying up to her flamboyant BFF Brad is especially genius.)
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Which online photo/image allow you to hotlink your images from that site? For those that do, are there any caps on bandwidth usage for hotlinking?
My own preference for image hosting is bayimg.com: It'll accept almost anything (so long as it's legal -presumably this means in the country in which bayimg is hosted- and preferably not pornographic), and allows hotlinking. It might be blocked in some places, though, due to its thepiratebay-connotations; but I've never had anyone tell me that a linked image isn't working, even at their workplace (and I've got quite a few friends in the (UK) health sector, government and other stereotypically/supposedly straight-laced places of employment). | |||||||||||||
Picasa Web Albums allows hotlinking and up to 1 Gigabyte of storage. | |||
I use ImageShack that allows hotlink. You can find additional info on FAQ page | ||||
For quick one-off and perhaps throw-away images, http://imgur.com has been good to me. Easy to use, no account nonsense, and hot-linking supported. The only caveat I find with it is images over 1MB get re-compressed. | |||||
Dropbox's public folder lets you do images (and pretty much any file type). 2 GB of free space, 20 GB of daily traffic for free accounts. | ||||
Flickr supports hotlinking as well, and they expose those URLs in the new "share this" menu item, and even have tools for posting embedded photos directly to your blog. | |||||


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CCM U+08 Hockey Elbow Pads Jr |
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The CCM U+ 08 hockey elbow pads offer great protection ideal for entry level to intermediate play. The U+ 08 elbow pads have a light low-bulk feel with a sleek design at a reasonable price.
The U+ 08 is a 2 piece elbow pad with Free-Flexx construction that connects the bicep guard to the elbow cap using elastic for improved mobility. They offer 2 adjustable straps and feature a deep elbow and forearm guard to allow the arm to sit deep inside the pad. The 08's utilize more plastic inserts and thicker foams over the U+04 model for a slight increase in overall protection.
- Model Number: EPU08
- Heritage: CCM U+ Fit05
- Level of Play: Ideal for entry level to intermediate play
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Pad size / Player height
Small / 4'4"-4'8"
Medium / 4'6"-4'10"
Large / 4'8"-5'
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- Deep molded asymmetrical elbow cap
- Segmented forearm protection with PE inserts
- Segmented bicep guard with PE insert with single density foam
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- Brushed nylon comfort liner
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- B.I.O. system with 2-piece Free-Flexx construction - Built Inside Outside out the Free-Flexx design that connects the pieces of elbow pad with elastic to allow improved mobility
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CCM Hockey Elbow Pads Junior & Youth
The CCM U+ 12 hockey elbow pads offer a secure fit with solid protection at a great value targeting the intermediate to advanced level player. CCM has used a two piece design with Free-Flexx construction connecting the 2 pieces with elastic for improved mobility.
The CCM U+ 08 hockey elbow pads offer great protection ideal for entry level to intermediate play. The U+ 08 elbow pads have a light low-bulk feel with a sleek design at a reasonable price.
The CCM U+ 04 Hockey Elbow Pads are the most affordable elbow pad in the CCM line-up. The U+ 04 elbow pads are lightweight and offer excellent protection for entry level to intermediate play.
The CCM Top Prospect elbow pads are made specifically for youth players. These elbow pads offer a good level of protection without restricting movement and they come at an affordable price.


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Gust, LLC
158 West 29th Street, 11th Floor
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info [at] gust.com
701 - 1155 Robson Street
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Cross Border Employer
Despite the recession, the lack of jobs and the training fees charged to U.S. employers hiring foreign workers on temporary H-1B work visas, the U.S. Department of Labor's ("USDOL") recently released Foreign Labor Certification Annual Report shows that U.S. employers are still struggling to find qualified U.S. workers in the fields of Science, Technology, Engineering and Math ("STEM"). Employers report recruiting for STEM positions for over two years in hopes of ultimately finding a qualified U.S. worker – often resulting in the employer losing lucrative contracts or having to resort to using contract workers.
Although an employer is not required to show the unavailability of a qualified U.S. worker when sponsoring a foreign national for a temporary H-1B work visa, an employer seeking to hire a foreign worker to work permanently in the U.S. must obtain a labor certification from USDOL before it can submit an immigrant visa petition to U.S. Citizenship and Immigration Services. Prior to submitting an application for labor certification, the employer must perform a labor market test to determine whether U.S. workers are able, willing, qualified and available for the position in the area where the job will be performed. If there are no such U.S. workers, the employer may file an application for labor certification evidencing the recruitment efforts undertaken and any results thereof. The employer must also demonstrate that employment of the foreign worker will not adversely affect the wages and working conditions of U.S. workers similarly employed. USDOL's Annual Report confirms that employers should not have a difficult time showing the unavailability of qualified U.S. workers for STEM positions.
Here are highlights of USDOL's FY 2010 Annual Report:
Recognizing the importance of STEM positions to the competitiveness of the U.S., President Obama's 2012 budget proposals seek $80 million to recruit 10,000 new science, technology, engineering, and math teachers in the next two years, with long-term plans of recruiting 100,000 teachers in the next ten years. STEM careers are outpacing other professions in annual growth rates. Therefore, employers who previously had polices against visa sponsorship are quickly realizing that sponsoring foreign workers for H-1B work visas and ultimately for U.S. permanent residence is a necessary investment to remain competitive in the global marketplace.
Education | Employment Contracts | Immigration | U.S. Permanent Resident
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What does it really mean by 'disarming' and 'triumphing' over rulers and authorities in Colossians 2:15?
In Col 2:15 He disarmed the rulers and authorities and put them to open shame, by triumphing over them in him.
Does the 'He' in the above verse referring to the 'he' in Genesis 3:15 ? Is that the reference to God's cursing Satan which made Adam and Eve fall in Genesis 3:14-15 ?
14 So the Lord God said to the serpent, "Because you have done this, Cursed are you above all livestock and all wild animals! You will crawl on your belly and you will eat dust all the days of your life. 15 And I will put enmity between you and the woman, and between your offspring and hers; he will crush your head, and you will strike his heel."
If this is the reference to Satan defeated by Jesus, what does it mean by the Satan being thrown out from heaven - does it mean that Serpent/Satan is not completely defeated but the defeat was only partial as it is thrown down onto the earth to fight with the people who keep God's commandments as in the verses from Revelation 12:7-12,17 ?
7 And war broke out in heaven: Michael and his angels fought with the dragon; and the dragon and his angels fought, 8 but they did not prevail, nor was a place found for them in heaven any longer. 9 So the great dragon was cast out, that serpent of old, called the Devil and Satan, who deceives the whole world; he was cast to the earth, and his angels were cast out with him.
10 Then I heard a loud voice saying in heaven, "Now salvation, and strength, and the kingdom of our God, and the power of His Christ have come, for the accuser of our brethren, who accused them before our God day and night, has been cast down. Rev 12:17 And the dragon was wroth with the woman, and went to make war with the remnant of her seed, which keep the commandments of God and have the testimony of Jesus Christ.
What is the current state of Satan? What powers have been revoked/granted before and after crucifixion?


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Mackinaw City Travel Guide
Why? A holiday in Mackinaw City means days full of fun and activity in Michigan's favourite holiday destination. The pretty town is a mix of old and new, with some historic attractions like a lighthouse and Fort Mackinac, complemented by numerous modern institutions like a thrilling waterpark, more than 100 shops, laser light shows, and golf courses. For nature lovers there are parks and of course, lovely sandy beaches. Many also travel to Mackinaw City for ferry access to delightful Victorian Mackinac Island.
When? The most popular time to travel to Mackinaw City is during summer, when cool breezes from the ocean moderate the summer heat, ideal for beach-going and outdoor activities. The population of this small town swells enormously during high season, so if you want to avoid the crowds, holiday in Mackinaw City in spring or autumn, when days are mild and nights cool.
Who for? Travel to Mackinaw City for the perfect family holiday. The town has something to suit everyone, from toddlers to grandparents.
More Info: For details of everything Mackinaw City has to offer, including opening and closing times for attractions and photographs, use our comprehensive Mackinaw City travel guide which is updated frequently and can be printed or emailed.
Mission Church, Mackinac Island © Mackinac State Historic Parks
Mackinaw City, situated in Michigan's Cheboygan County at the top of the state's Lower Peninsula, is linked to the Upper Peninsula by one of the world's longest suspension bridges. The city has become Michigan's most popular vacation destination, offering many attractions and acting as a gateway to the scenic Upper Peninsula with its hiking trails, state parks and recreation areas, and sandy beaches.
The city itself has a rich history, having been first settled after French explorer Jean Nicolet negotiated with the local tribes in 1634. It became a fur-trading post and later the site of a busy fort and trading store. By 1882 the settlement had become a flourishing town; today it is a shopping destination, offering many unique stores and restaurants lining its main street and boasting more than 50 hotels and holiday resorts. Regular ferry services connect the city with historic Mackinac Island just offshore.
Become our Mackinaw City Travel Expert
We are looking for contributors for our Mackinaw City travel guide. If you are a local, a regular traveller to Mackinaw City or a travel professional with time to contribute and answer occasional forum questions, please contact us.


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"Mouth-watering pork cooked in a slow cooker with beef broth served with barbecue sauce."
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Holiday cookies, cakes, pies, and breads. Get recipes and inspiration.
Get time-saving recipes to save your busy life.
Find just the right recipes for your holiday get-togethers.
This tasty pork is great on your favorite bun. It's simple to make, too.
Turn pork shoulder into delicious shredded BBQ pork for sandwiches.
This pulled pork is so easy to make in your slow cooker.


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Members visit free all year! Purchase and visit today.
Avoid the line! Print your tickets at home.
Are you a student with a strong understanding of online communications? Can you build a Facebook and/or YouTube landing page, make updates to a site using a content management system and html and possess a basic understanding of Google Analytics? If the answers to the above are yes, we have a great opportunity for you!
College Junior or Senior with a concentration in Marketing, Communications, Journalism or related field. Proficiency in Microsoft Office A grade point average of 2.5 or higher
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