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Latest News
VPH2012 Theme Issue in Interface Focus
A new theme issue of the Journal of the Royal Society Interface Focus is available online (will be available in print: 6 April 2013). The issue, "The virtual physiological human: integrative approaches to computational biomedicine", was edited by Peter Coveney, Vanessa Diaz-Zuccarini, Norbert Graf, Peter Hunter, Peter Kohl, Jesper Tegner and Marco Viceconti. You can view the theme issue here, it contains selected papers from the VPH2012 conference.
Call for papers: ICIBET 2013
The 2013 International Conference on Information, Business and Education Technology (ICIBET 2013) will be held in Beijing, China during March 14-15, 2013. The aim objective of ICIBET 2013 is to provide a platform for researchers, engineers, academicians as well as industrial professionals from all over the world to present their research results and development activities in Information, Business and Education Technology. This conference provides opportunities for the delegates to exchange new ideas and application experiences face to face, to establish business or research relations and to find global partners for future collaboration.
The submission deadline is November 30th 2013. For more information, please visit the website
REGISTRATION OPEN for 2nd Consultation Meeting on the 'Digital Patient'; Barcelona, 26-27th of Novem
REGISTRATION OPEN for 2nd Consultation Meeting on the 'Digital Patient'; Barcelona, 26-27th of November 2012
*Please note that the 26th is a networking session and the main event is on the 27th*
The DISCIPULUS project, an undertaking established by the European Commission in October 2011 to set up a roadmap for the "digital patient" will be organising an open consultation meeting on the 26th and 27th of November 2012 in Barcelona, in order to inform the 'Digital Patient' Roadmap. And we need our community behind us.
For a timeline of the project, please visit: http://www.digital-patient.net/project.html
This open meeting will call on worldwide experts within and outside the VPH community will identify and propose recommendations for the Roadmap for the Digital Patient. Views will be invited to discuss the outcomes of the First Consultation Meeting (March 2012) and to propose specific actions to update the draft Roadmap (http://www.digital-patient.net/files/DISCIPULUS_D6-2_Draft_Roadmap_final.pdf )
Any member of the community wishing to get involved in the production of the final roadmap can do so on our dedicated forum at www.biomedtown.org/biomed_town/discipulus/reception/forum
We also invite technology and clinical experts to write their views on our wikipages at www.biomedtown.org/biomed_town/discipulus/reception/wiki
The registration for the 2nd consultation meeting opened on the 5th of September 2012 and registrations will be accepted (on a first-come, first-served basis) until reaching the maximum capacity of the room we've booked. DISCIPULUS will contribute to your accommodation expenses, as explained in the registration page.
To register, please go to Digital Patient website: www.digital-patient.net
Model-Based Medicines Development" seminar in Lyon 2012
The Evaluation and Modeling with the Therapeutic Effects (EMET) Group at the University Claude Bernard
Lyon 1 (Lyon, France) is organizing a "Model-Based Medicines Development" seminar that will take place
on the Laennec campus in Building A, Amphitheater A4 on December 10-11, 2012.
All presentations will be given in English.
For more information, please log on to the EUDIPHARM Master's Degree website:
5th International Congress on Automation and Autoimmunity
The 5th International Congress on Automation and Autoimmunity is being organized by the European Medical Association and will be held in Brussels on 27th September 2012. The 1st, 2nd and 3rd and 4th International Congress on Autoimmunity took place in Brussels, Belgium in April 1995, April 1999, February 2008 and September 2010. All congresses attracted a large attendance. Participants included: immunologists, rheumatologists, researchers and clinicians, dealing with autoimmune diseases.
For further details please click here
Read more...
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Study: Better TV might improve kids' behavior, avoid aggressiveness
Low-income boys got most short-term benefit
(Photo courtesy: Peter Macdiarmid/Getty)
Copyright Getty Images
Posted: 02/18/2013
Last Updated:
296 days ago
SEATTLE - A new study has found teaching parents to switch channels from violent shows to educational TV can improve preschoolers' behavior, even without getting them to watch less.
The results were modest and faded over time, but the study authors and other doctors say they may hold promise for finding ways to help young children avoid aggressive, violent behavior.
The research involving 565 parents was published online Monday by the journal Pediatrics.
They periodically filled out TV-watching diaries and questionnaires measuring their child's behavior.
Half were coached for six months on getting their 3-to-5-year-old kids to watch shows like "Sesame Street" and "Dora the Explorer" rather than more violent programs like "Power Rangers."
Low-income boys appeared to get the most short-term benefit.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

subset: commoncrawl


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1 Meetup Group matches "ExpressionEngine" near San Diego, CA
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Welcome to the San Diego ExpressionEngine Meetup group! This is a group of web designers and developers who use and love the ExpressionEngine Content Managment System. As you might imagine from our group name our members are based throughout San Diego county. If you are new to the CMS world you might consider joining our group and learning why EE might be a great fit for you and your business. If you are from an agency or company looking to learn more about this great CMS and want to meet the pe …
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Taking a Stand, 1848
Adding controversial amendments to important bills is one tactic used by supporters of a bill to make other lawmakers confront and vote on difficult issues. Representative David Wilmot of Pennsylvania used this technique in a classic example of parliamentary acrobatics. In 1846, Wilmot successfully added to an appropriations bill (one that authorizes necessary government expenditures) an amendment prohibiting slavery in all territory taken during the Mexican War. The Senate, where the South was stronger, let the bill die. The antislavery House majority continued adding Wilmot's proviso to other important bills, constantly forcing legislators to face the volatile question of expanding slavery.
Capture of O'Brien's Guns at Buena Vista, by Samuel E. Chamberlain, ca. 1850s
The Mexican War added more than 500,000 square miles to the nation and raised the question in Congress of whether slavery should be allowed in the new territory.
The San Jacinto Museum of History, Houston
Wilmot Proviso, 1846
Representative David Wilmot of Pennsylvania introduced an amendment to prohibit slavery in the territory acquired from Mexico. The amendment failed, but the issue of slavery dominated congresses in the 1850s.
Records of the U.S. House of Representatives, National Archives and Records Administration, Washington, D.C.


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Road repairs to slow traffic on Gayton
A section of Gayton Road will be restricted to one lane, beginning Monday, Sept. 24, while a contractor makes repairs at the crossing of Deep Run Creek.
Gayton's eastbound lane will be closed near the creek, which is between Monmouth and Cedarbluff drives. All traffic will be directed to Gayton's westbound lane. Temporary traffic signals will guide eastbound and westbound motorists in alternating fashion through the work zone. The Henrico County Department of Public Works (DPW) expects the road repairs to take about three weeks to complete. The contractor will be working seven days per week to fix deteriorated concrete in a box culvert that allows the creek to flow under the road and to reattach a guardrail. In advance of the lane closure, DPW will place digital message boards along Gayton to alert motorists about the road work and expected delays. |
Strikers, Kickers form partnership
Citizen Staff Reports 12/03/2013
The region's two premier youth soccer organizations – the Richmond Kickers and Richmond Strikers – have partnered to create Richmond United, a cost-free U.S. Soccer Development Academy program designed to serve the most talented players in the region. The arrangement marks the first time in U.S. Soccer Development Academy history that two member clubs have united their respective Academy programs.
Slated to begin play in the fall of 2014, Richmond United will field U13/14, U15/16 and U17/18 U.S. Soccer Development Academy teams. The teams will train and play home games at two of the top soccer specific complexes in the nation, Ukrop Park and Striker Park. > Read more.
Gettin' piggy with it at Henricus
Photo by Roger Walk for the Henrico Citizen 11/24/2013
Henricus Historical Park has a new, messy guest. Eleanor, a rare five-month-old Tamworth pig, was donated this month to the Chesterfield park by the Chesterfield County Farm Bureau as part of an effort to enhance the living history museum's partnership with the Virginia Foundation for Agriculture in the Classroom. Eleanor and her livestock pig and goat neighbors at the park will be a special attraction for the schoolchildren and others who visit the Henricus Historical Park. Eventually, she will triple from her current 150-pound weight and grow to about two feet tall. > Read more.
Marathon spirit
Members of Triangle II, a community service club at Hermitage High School, braved the elements Nov. 16 to serve as a spirit team at the Richmond Marathon, providing half-marathoners with cheers, motivational signs and shouts of encouragement as they ran through Bryan Park. > Read more.
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AMC television series seeks background actors
The new AMC television series "TURN" is currently being filmed in and around Richmond, and casting officials are seeking background actors to appear on screen.
"The background actors are profoundly important to the filmmaking process," said Erica Arvold, casting director. "The show takes place during the Revolutionary War, and background actors contribute to the atmosphere of that era." > Read more.
Scene sparkles, food falls flat
American Tap Room's new Willow Lawn location offers breath-taking atmosphere, but average dishes
On a rare warm night in late November, the newly opened American Tap Room was, to my surprise, bright and packed with guests – many eating outside.
I didn't have a clue what to expect from this unheard-of restaurant in an unexpected spot – right in the heart of Willow Lawn. I came to learn it's not unheard of; it's a restaurant chain out of Northern Virginia.
"It definitely improves the look of Willow Lawn," said my friend, who ventured to the new spot with me on a Monday night for dinner one week after the restaurant opened. > Read more.
Overstuffed turkeys
Free Birds offers some giggles, but more eye-rolling
Thanksgiving season is upon us – a time for friends, family, and recklessly indulgent overeating. As we settle into our annual turkey-induced food coma, there's no better time to take in a festive holiday film. And Free Birds, for better or worse, has the distinguished honor of being one of the only Thanksgiving-themed movies currently on the market.
The film stars Owen Wilson and Woody Harrelson as Reggie and Jake, two turkeys who can't stand the Thanksgiving tradition of watching their neighbors be plucked and served for dinner. > Read more.
More News
Henrico fifth-graders win honors in historical essay contest
Business in brief
Meals tax expected to begin May 1
'Too Smart 2 Start' earns nonprofit status
Christmas wish-kids
Hospital receives handmade items
Business in brief
A love affair with nature
4 Henrico teachers earn REB awards
Deep Run robotics team hosts meet
- More Henrico News
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How to get free next-day shipping with Zappos for Windows 8
Zappos has released its Windows 8 shopping app just in time for the holidays. Though the app can be used on any system that runs Windows 8, it's tailor-made for the touch screen, which should benefit users with devices like the Microsoft Surface or the Dell Venue 8 Pro.
The entire catalog of products is available for purchase with the Zappos app. To encourage Windows 8 users to place orders with the app, Zappos is offering free next-business-day shipping through the end of the year (US customers only).
Zappos already offers free standard shipping, but next-day shipping normally costs … Read more


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Crash and Burst
Two neutron stars collide in one very big bang.
Imagine a dead star the size of a city and with more mass than our sun. Now imagine two of these ultra-heavy spheres smashing into each other, generating a blast bright enough to outshine an entire galaxy. Scientists have recreated just that using supercomputers to model what happens during the collision of two neutron stars. The entire process unfolds in just 35 thousandths of a second, but what this new analysis reveals is how the tangled magnetic field lines of the collapsed neutron stars restructure around a black hole, focusing a narrow stream of particles that jet into space at 99.995 percent the speed of light. Scientists believe events like this are one source of gamma-ray bursts—the powerful flashes of light from beyond the Milky Way that were first detected by satellites in the late 1960s. Watch the visualization below to see this lightning-fast cosmic wreck evolve in super-slow motion.
NASA/Goddard Space Flight Center
Image courtesy of NASA/AEI/ZIB/M.
Image Source: http://svs.gsfc.nasa.gov/vis/a010000/a010900/a010947/


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Fun. Pictures & Photos
Fun. Picture & Photo Gallery
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Fun and Walk the Moon in Concert at TMN Ao Vivo in Lisbon - October 23, 2012
TMN Ao Vivo
Lisbon, Portugal 10/23/2012
Rui M. Leal / PR Photos
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Hotel Baron Reviews
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Reviews & Ratings Explained
The rating percentage is calculated from customers who booked within the last 12 months.
All ratings and reviews are based on the feedback and opinions of the customers who submitted them and do not express the opinions of Hostelworld.com. This way, you get an up-to-the-minute opinion of just how good a hostel really is.
Read our review guidelines »
Basic hotel amenities, very clean. Friendly staff, though I would have appreciated an answer to my emails prior to arrival. The location is excellent with plenty of good restaurants in the immediate vicinity of the hotel. Also the Bier Baron restaurant and tavern within the hotel is worth a visit with it's delicious bar menu and incredibly large selection of beers. The most important sights are a short metro ride away, the riverside can also be reached easily by a nice walk through Georgetown.
- Novice Nomad
- Anonymous
- Finland
- Couple, 25-30
- (4 reviews)
Nice place to stay - very clean, included all the basics and great value breakfast. Little bit out of town if you are there to sightsee but great value if you don't mind getting the subway.
- Novice Nomad
- Anonymous
- Australia
- Female, 25-30
- (1 review)
A great location with plenty of bars, restaurant amenities in very close proximity for a low price. Subway close by and bus routes everywhere. The wifi was not reliable in our room. Signal would cut out then randomly connect again. The staff member who checked us in was extremely friendly and helpful. He changed our room upon arrival to somewhere quieter and gave us plenty of information for our stay. Breakfast was disappointing. Not much choice. Bar/restaurant below is a must visit!
- Novice Nomad
- Anonymous
- England
- Male, 25-30
- (1 review)


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Engadget: The iPhone 4 is no small thing to review. As most readers of Engadget are well aware, in the gadget world a new piece of Apple hardware is a major event, preceded by rumors, speculation, an over-the-top announcement, and finally days, weeks, or months of anticipation from an ever-widening fan base. The iPhone 4 is certainly no exception — in fact, it may be Apple's most successful launch yet, despite some bumps on the road. We've already seen Apple and AT&T's servers overloaded on the first day of pre-orders, the ship date for the next set of phones pushed back due to high demand, and die-hard fans in line outside of Apple locations a week before the phone is actually available. It's a lot to live up to, and the iPhone 4 is doing its best — with features like a super-fast A4 CPU, a new front-facing camera and five megapixel shooter on the back, a completely new industrial design, and that outrageous Retina Display, no one would argue that Apple has been asleep at the wheel. So the question turns to whether or not the iPhone 4 can live up to the intense hype. Can it deliver on the promises Steve Jobs made at WWDC, and can it cement Apple's position in the marketplace in the face of mounting competition from the likes of Google and Microsoft? We have the answers to those questions — and many more — in our full review, so read on to find out!
Perhaps the most notable change with the new iPhone is the drastic industrial design overhaul — Apple seems to have completely rethought its strategy on how the phone should look and feel, and the results are nothing if not striking.
Industrial design
In his WWDC keynote, Steve Jobs likened the design of the iPhone 4 to that of a "beautiful, old Leica camera," and as we've said before, he wasn't off the mark. Instead of hewing to the curved, plasticky, silver-bezeled look of the iPhone 3G and 3GS, the company has turned the casing and face of the device into something decidedly more detailed and sophisticated. From the design aesthetic through to the actual build process, Jony Ive and his team have reset what we expect in an iPhone, coming up with something that clearly harkens back to the retro-future Braun designs of Dieter Rams. The iPhone 4 is made up of three basic parts: two pieces of smooth, strengthened glass, and a stainless steel band which wraps around the sides, top, and bottom of the phone. The effect is clean but not simple, and Apple has added little details, like altered volume buttons (what used to be a rocker is now separated into circular clickers labeled + and -), and notches in that metal band which serve to improve radio connections (more on that in a minute). The phone is noticeably thinner than the 3GS at .37 inches compared to .48 inches, but it weighs the same 4.8 ounces, making the whole package seem tighter and denser. It feels great in your hand, with good heft, although it might take a little time to get used to the lack of a rounded back if you're coming from the 3G or 3GS.
We can't overstate how high-end the design of the iPhone 4 is. The 3GS now feels cheap and chubby by comparison, and even a phone like the HTC Droid Incredible — which just came out — seems last-generation.
As we said, there are three main pieces of the phone, which together create an effect not wildly dissimilar to that of an ice cream sandwich. You know, but far pricier… and not edible. The face of the device is made up of extremely strong glass which Jony Ive says is "comparable in strength to sapphire crystal, but about 30 times harder than plastic." A small slit for the earpiece and the front-facing camera are embedded in the glass above the display, with the familiar home button towards the bottom — a button we should note feels much clickier than on our 3GS. On the left side of the phone you've got the new volume buttons, a redesigned mute switch, and a small notch towards the base of the unit. On the right side is the Micro SIM slot and another notch in the band at the bottom, and up top there's the power / sleep button, headphone jack, another notch, and new noise-canceling microphone. Along the bottom is a speaker, microphone, and the 30-pin dock connector port. The backside of the phone is made from the same kind of ultra-strong glass as the front, interrupted only by the new five megapixel camera, its LED flash companion and, of course, the Apple logo.
Overall, the iPhone 4 outclasses pretty much every smartphone on the market in terms of industrial design. It just comes off like a far more expensive device, like a Mobiado or Vertu — but better designed. And it's not just the way the phone looks; the materials feel good — premium — in your hands. The first few days we had our test unit, we were definitely freaked out about dropping or losing the phone, and some of that had to do with the fact that it's just a really beautiful device to use and hold.
It's not just the face of the phone that's undergone a transformation — the iPhone 4 is all new inside as well. For starters, Apple has moved on from the Samsung-built ARM Cortex-A8-based CPU used in the 3GS to its custom A4 chip used in the iPad, which funnily enough… is an ARM Cortex-A8-based CPU. While the company hasn't yet said what the clock speed of the processor is, we're guessing it's something below the 1GHz touted for its tablet cousin. The phone is definitely snappier than the 3GS, so we're not about to volley complaints just yet — in particular, graphics seemed to render faster, and overall responsiveness was slightly higher, though admittedly, it wasn't blowing the doors off the joint. It's certainly faster, but the 3GS wasn't hurting on speed to our eyes, so it's not as wildly noticeable a leap as the 3G to the 3GS.
As usual, Apple isn't fessing up about the RAM situation, though we have on very good authority that the iPhone 4 has 512MB onboard, a big step up from the 256MB in the previous model and the iPad. We would have liked to see it futureproofed with something like 1GB, but then again, Apple's got to sell a new phone in a year. As far as internal storage goes, you can buy the new iPhone in either 16GB ($199 on contract) or 32GB ($299 on contract) capacity — fine for now, but since the company has just introduced 30FPS 720p video recording, you could find yourself outgrowing that number pretty quickly. It's a little odd, in fact, that the company didn't double down here and bump the capacity to 64GB, as it's recently done with the iPod touch. In terms of wireless, the iPhone 4 is packed with an 802.11n WiFi radio, as well as a quad-band HSUPA chip and Bluetooth 2.1.
The redesigned housing allows for a much larger lithium-ion battery on the inside, providing improved numbers for Apple's life ratings (more on that in a moment), though it's still not easily replaceable. Additionally, the new phone has those two new cameras (VGA up front, five megapixels with LED flash around back), a new second microphone used to combat background noise while on calls (similar to the Nexus One), a gyroscope in addition to the standard accelerometer, a light sensor, and a proximity sensor. As with the 3GS, an AGPS chip and compass are bundled somewhere in that tiny frame as well.
Of course, the big internal story is what has become external: namely, the UMTS, GPS, WiFi, and Bluetooth antennas. Apple has made the stainless band around the phone essentially a couple of big antennae, and they seem to be doing a pretty good job at hanging onto radio signals. The big question is obviously whether or not this fixes or helps with the constant dropped calls iPhone users on AT&T's network have gotten used to. Well in our testing, we had far, far fewer dropped calls than we experienced on our 3GS. Let's just say that again: yes, the iPhone 4 does seem to alleviate the dropped call issue. It wasn't perfect, and we had some connection issues in downtown New York City in particular, though it's tough to say if it was the fault of our phone, the cluster of buildings we were near, or the person we were speaking to, who was on a 3GS in the same location.
By now you should know that iPhone 4 has an all-new display, as well. Apple is calling the LED backlit, 960 x 640 IPS screen the "Retina Display" due to its high resolution and pixel density. At the same 3.5-inches as the older screens, the new display manages an insane 326ppi pixel density along with an 800:1 contrast ratio. Steve made a huge point about the science behind this technology during his keynote, claiming that the resolution of the screen essentially tops what is perceivable by the human eye. There have been some debates as to whether or not this argument holds water, but we can tell you this: to our eyes, there has never been a more detailed, clear, or viewable screen on any mobile device.
Not only are the colors and blacks deep and rich, but you simply cannot see pixels on the screen. Okay, if you take some macro camera shots or get right up in there you can make them out, but in general use, the screen is free of jaggies of any type, unless you're looking at a last-gen app that hasn't had its artwork updated. Text rendering is incredibly clear and clean — webpages that would be line after line of pixelated content when zoomed out on a 3GS (say, Engadget or the New York Times) are completely readable on the iPhone 4, though the text is beyond microscopic. It's impressive, and doubly impressive when you look at higher-res graphics or watch 720p video on the phone — the detail in moving images is particularly striking. What's nice is that most apps with text in them will benefit from this tech whether or not they've been updated, as long as they're using Apple's font rendering. Text in the Engadget app, for instance, looks cleaner, clearer, and much easier to read on the new iPhone.
Because Apple is using IPS and LED technology for its screen, the iPhone 4 is mercifully visible in full sunlight, and performance in low light and at extreme viewing angles are favorable. Overall, you simply won't find a better display on a phone, and that's not just lip service.
The cameras on the new iPhone are going to be a topic of much debate, since this has been an area where Apple has been slow to innovate. The 3GS sported a measly three megapixel shooter with few bells and whistles (and no flash), and while it was fine for quick snaps, it wasn't an artist's tool by any means. The company finally seems to be listening to a public that's interested in leaving the point-and-shoot at home in favor of a phone with a capable camera, by adding a five megapixel shooter to the backside of the iPhone 4 and a VGA camera up front.
Let's first take a look at the higher-res main camera. At his WWDC keynote, Jobs said that getting great looking images wasn't just about upping the camera's megapixels, but had more to do with grabbing more photons. Increase the photon count, let more light in, and your images will look better, the thought goes. So Apple's using a newer backside-illuminated sensor that's more sensitive to light in addition to upping those megapixels — and we must say, pictures on the iPhone 4 look stunning. Our shots looked good right out of the gate, with few problems when it came to focusing or low light. With the flash on, we managed decent if somewhat blown out results (fairly common with smaller LED flashes) though impressively, the iPhone 4 was usually able to take completely useable and even handsome photos in fairly low light without the flash. It seems like that photon situation is definitely in play, because even shots taken in fairly dark lighting came out looking good. Autofocus worked well in most situations, and we were actually able to get some impressive looking macro shots (see the flowers and Penny below). In general, we'd have no trouble using the iPhone 4′s camera as a stand-in for a dedicated camera. Not only did it take beautiful shots, but the A4 and iOS 4 combo have considerably sped up the time it takes to snap pictures — it's now almost instantaneous. Otherwise, you have options for a 5x digital zoom (which produces results that look like a digital zoom) and basic on / off / auto settings for the flash. It's pretty bare bones, and we wouldn't have minded a few basic options like white balance settings — but c'mon, this is Apple we're talking about. Luckily, the App Store is chock full of applications that improve upon the stock camera app — we expect to see a handful of new ones that take advantage of the new sensor soon.
As far as video goes, we were definitely impressed by the 720p capture, though there are stability issues with the lens and the all-too-familiar "jellyvision" CMOS issues that tend to rear their head if you're not holding the phone very steady. Still, we can't see carrying around a Flip HD instead of just keeping this in our pocket (though as we said, we'd like to see a higher storage capacity). Everything we shot looked crisp and mostly artifact-free, and we didn't see any hiccups in the 30 FPS rate Apple claims, even in lower light. Adding iMovie to the mix for on-the-fly editing is a nice touch too (more on that in the software section).


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- Active (503)
- Anti-irritant (120)
- Antimicrobial (98)
- Antioxidant (22)
- Colorant/Pigment/Hair Dye (102)
- Conditioner/Moisturizer (261)
- Delivery (161)
- Exfoliant (13)
- Feel Enhancer (188)
- Film-former (15)
- Formulating Aids (137)
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- Preservatives (82)
- Repair (101)
- Rheology/Viscosity Modifier (94)
- Surfactant/Emulsifier (142)
- UV Filter (118)
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Clinical Relevance of Topical Active Delivery Systems in Cosmetics
By: Haw-Yueh Thong, MD, MS, Dnational Taiwan University Hospital and Howard I. Maibach, MD, University of California
Posted: May 4, 2009, from the May 2009 issue of Cosmetics & Toiletries.
Depending on a drug or cosmetic ingredient's intended target, topical delivery systems are broadly categorized as either transdermal drug or dermal drug/cosmetic.1 Transdermal drug delivery (TDD) is the controlled release of drugs through intact skin to obtain therapeutic levels systematically and to affect specified targets for specific purposes such as contraception, among others. Dermal drug/active cosmetic ingredient delivery (DDD) is similar to TDD except that the specified target is the skin itself.1,2 Cosmetic ingredients, including those for antiaging, known as cosmeceuticals, presumably may have the same site of action. The cosmetic and/or transdermal route is indeed desirable by the industry but the success of DDD and cosmetic active ingredient delivery (CAID) technologies remains limited and faces many challenges, one of which is low skin permeability that hinders the development of DDD/CAID for macromolecules.
Overcoming the skin barrier safely and reversibly while enabling percutaneous absorption is a fundamental problem in the field of CAID, TDD and DDD. Advances have been made in recent decades to overcome skin barrier properties,3,4 including physical means such as iontophoresis, sonophoresis and microneedles; chemical means using penetration enhancers; and biochemical means such as liposomal vesicles and enzyme inhibition. A rich library of textbook literature summarizes these extensive experimental backgrounds—largely within the last half of the 20th century.5,6
CAID Systems
CAID systems are capable of delivering localized effects while minimizing systemic side effects and they are the primary modalities for dermatologic treatment or cosmetic purposes. Examples include topical antiaging products, photo-protective materials, cosmetics and moisturizers. Many cosmetic formulations use chemical penetration enhancers to overcome the skin barrier. Again, percutaneous absorption remains a key issue to the success of CAID technology.
As a model for CAID, delivery systems of topical corticosteroids and their pharmacokinetic/pharmacodynamic relationships have been studied extensively as aids to optimizing topical treatment.7-9 For instance, the correlation between the bioavailability of topical corticoids and the thermodynamic activity of the medicament in different bases have been studied.10, 11 Unfortunately few such in vivo human studies have been performed for active cosmetic ingredients.
In a similar investigation, Leopold and Maibach12 characterized local anesthetics pharmacodynamically by measuring thermal thresholds over time with a thermal sensory analyzer (TSA) in human subjects. The results showed that the local anesthetics investigated affect thermal thresholds to a different extent, and that linear relationships exist between cold sensation parameters and the solubility of the local anesthetic bases in medium chain triglycerides and with the drug flux at 50% saturation.


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i dunno if u call this a CPU Socket backplate or what u call it, but is it safe to remove so i can install a stuck cooler bcs, i tried pushing it with my fingers, but it don't come off the pcb so i think it maybe taped with some thermal tape or something... i need to install stock Intel CPU cooler from my i5-2500K but with that backplate thing the pop-pins can't go through the pcb holes and lock itself into place. so some help here would be nice ^^ pic of the front of the cpu socket with Intel Pentium G650 installed:
should ain't always what it appears to be, bcs i can't to that with my fingers, i dunno why feels like it's sticking to the back of the pcb and i don't wanna break something trying.
It's supposed to stick so it doesn't fall off when the heatsink is removed. Just finesse it a little. It should be able to be come off with just your hands, but if not, find something that won't scratch the board. It's unlikely that it would be permanent, at least that's what my experience has shown.
wich motherboard is that ? If pre-build like HP,Compaq, Dell or something else i suggesto to you do not bother change anything they are glued for sure. Try to heat that backplate and try to remove it.
use a blow dryer to heat it up first if it still dosen't come off with ease you do risk tearing up the board.
it's a SuperMicro C7Q67: http://www.supermicro.com/products/motherboard/core/q67/c7q67.cfm from other pics on google i have found of this board they don't have this cpu socket backplate on u can even buy it so i guess it may be removable but, i don't have a hair dryer i can use :/ but maybe i can borrow one from my sis ^^;
Anything oem using adhesive is evil, Part is screwed down to the mother board 99% of the time, cover it in glue Part has potential to fall off and cause damage, a piece of tape will do.
Don't "pry" it. Give the top side of the board where it pokes out through the holes a few taps with a small hammer (have a stead hand,) It only holds the cooler on so there should be absolutely nothing holding it on. It should come off fairly easily once you get it to move. Be gentle and patient with it. The picture clearly shows that there isn't anything screwed in to hold it in place. Maybe adhesive but when the CPU is mounted it should hold on just fine even without it so there really is no need. You only need a non-conductive layer between the plate and board.
I have seen older MSI boards with the backplate attached with an adhesive of sorts but that was quite a few yrs ago and I killed the board trying to pry the sucker off, so be careful
also when you heat it up try twisting it instead of pulling straight up a thin piece of plastic like a guitar pick to pry with may also help heat really is the key to making this much easier my point was it should come off easily since there should only be a lil bit of sticky stuff to hold it there since the cooler holds it in place 99% of the time instead its covered with adhesive for no reason.
i got the cpu socket backplate off now it took a lille nic nic on the pcb, but i think i will go and borrow some of my sis nail polish to cover it up, i just hope she got a green one ^^;
thats weird. that is supposed to be easily removeable. is it second hand? because that might explain why someone double sticky taped it to the back of the motherboard permanently. anyways no harm done as the scratched bit is a part of a bigger trace.. and just a tip for the future, if you want to pry something off gently, use a blunt screw driver with the tip covered in masking tape(any tape will do, just make sure the glue on the tape is strong).
it's actually SuperMicro's original CPU Socket backplate, so i dunno why it's so hard, used hairdryer and than i could take it off, but i will borrow a little green nail polish from my sis, to cover the small scratches later.


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Televisions come with cable channels. Guestrooms also feature complimentary wireless Internet access, air conditioning, and coffee/tea makers.
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A complimentary breakfast is offered each morning. High-speed wireless Internet access is complimentary. This Taos hotel also offers complimentary newspapers in the lobby and RV/bus/truck parking. Complimentary parking is available on site.
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Guests are offered a complimentary continental breakfast each morning.
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When porting RTEMS to a new CPU architecture, one will have to have a development environment including compiler, assembler, linker, and debugger. The GNU development tool suite used by RTEMS supports most modern CPU families. Often all that is required is to add RTEMS configurations for the target CPU family. RTEMS targets for the GNU tools usually start life as little more than aliases for existing embedded configurations. At this point in time, ELF is supported on most of the CPU families with a tool target of the form CPU-elf. If this target is not supported by all of the GNU tools, then it will be necessary to determine the configuration that makes the best starting point regardless of the target object format.
Porting and retargetting the GNU tools is beyond the scope of this manual. The best advice that can be offered is to look at the existing RTEMS targets in the tool source and use that as a guideline.
Copyright © 1988-2004 OAR Corporation


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Empty Places
Anatolia, July 2013.
I had just this big old camera with me: an Hasselblad Swc with a very wide lens, and black and white films. "Slow photography", with an unusual lens and format. 2013 Journalism, Photography -
The Cat
I started to follow this cat... Or the contrary. In any case we were alone. Nobody around. The place is in Turkey, over the mountains in Anatolia. An old hospital, with a mosque beside, both in the World Heritage Unesco list.
After a while, the Imam arrived. 2013 Photography - Three Chairs Three groups of pictures, wrapped around a Thoreau's quote: "I had three chairs in my house; one for solitude, two for friendship, three for society". 2013 Photography
Ethiopia 2003: Lalibela, Omo Valley
Ethiopia 2009: Danakil, Tigray 2013 Photography, Photojournalism -
August 2007:
Ulaan Bator, Batsumber, Amarbayasgalant, Delgesrtdog, Dürvan Saihhan, Korkorin, Ulaan Bator, Gobi Desert, Mandalgovi
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A simple travel, with a small bag and a camera. 2013 Photography, Photojournalism -
Visited India:
July 1993
December 1998
December 2005
March 2010 2013 Photography -
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Agra (Switzerland), Old Sanatorium.
In the first half of the 20th century, Agra was particularly famous for its sanatorium, which opened in 1913: a place for patients suffering from tuberculosis. Bill Brandt was treated in Agra in 1923. The sanatorium closed its doors in 1969. Now it is a luxury residence. 2013 Photography - Romania May 2009 and October 2012, Maramures, Bucovina, Transylvania 2013 Photography
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My first visit to Havana, January 2012.
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Back to Cuba. Summer 2012.
L'Habana, Santiago, Baracoa, Camagüey, Trinidad. 2013 Photography - Kids Kids portraits, here and there. 2013 Photography
- The Mirror Stage Personal evidence of the 'mirror stage'. 2013 Photography
Six Six
Mixed pictures in medium format, 2012.
2013 Photography


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Civil War Interactive Discussion Board > Civil War Talk > Other Civil War Talk > What Is a Civil War Round Table? |
Moderated by: javal1 | Page: 1 2 3 |
What Is a Civil War Round Table? | Rate Topic |
Author | Post |
Posted: Sat Feb 16th, 2008 04:48 am |
41st Post |
susansweet Member
Guess there was a reason you couldn't join that group. You were meant to join the one you did. Sounds like a fun group you have joined. Susan |
Posted: Sat Feb 16th, 2008 05:26 am |
42nd Post |
ole Member
It's nice to know the CWRT in our community is the exception to the rule. Everything turned out for the best, however, as we became affiliated with a group from Lawnfield, President Garfield's home. Thank goodness you got past that pint of peverts. I've never heard of a Round Table that wants no women! Most of them would appreciate a warm body. Good to hear that your further search worked out better. Even if they allowed you to attend, they were likely too stupid to bother with. Geez. ole |
Posted: Wed Feb 20th, 2008 03:24 am |
43rd Post |
Lincoln Fan Member
Thought I'd give you all an update from the all-male CWRT area of Ohio. I had breakfast this AM with some people from my Lawnfield group. One of their guests was a gentleman who is a member of the Toledo Ohio CWRT. He spoke very highly of their woman president (kj3553 would that be you?). I am up that way quite often during the summer months and he told me to look them up, which I just might do. |
Posted: Wed Feb 20th, 2008 05:10 am |
44th Post |
kj3553 Born in the wrong century
Lincoln Fan wrote: Thought I'd give you all an update from the all-male CWRT area of Ohio. I had breakfast this AM with some people from my Lawnfield group. One of their guests was a gentleman who is a member of the Toledo Ohio CWRT. He spoke very highly of their woman president (kj3553 would that be you?). I am up that way quite often during the summer months and he told me to look them up, which I just might do. Why yes! As a matter of fact, I am. May I ask who it was who spoke so highly of me? I'd like to pay him off. I mean, thank him. (I'm scratching my head, trying to think who told me they were going to be around your neck of the woods.) I've been president for...too many years. I've told the club that this is my last year, that some "new blood" needs to step up and take over. I'm ready to retire and sit on my laurels...and get back to working on my 14th OVI research. |
Posted: Wed Feb 20th, 2008 04:42 pm |
45th Post |
ashbel Member
kj Good luck on retiring. It has never worked for me with my Round Table. I am on my 12th year. |
Posted: Wed Feb 20th, 2008 07:15 pm |
46th Post |
kj3553 Born in the wrong century
One fellow asked if anyone's stepped forward yet and express an interest in the job. Nope, I told him. At the same time, I haven't been exactly out banging on drums yet, trying to beat 'em out of the bushes. It's a few months away from our elections, so I've got time. But I'm serious about not wanting to be president anymore. I've been telling folks I'll continue doing the newsletter and our website, and work as a trustee at board meetings, but it's time to let someone else bang the gavel. Just have to wait and see. |
Posted: Thu Feb 21st, 2008 02:44 am |
47th Post |
susansweet Member
Our long time founding female president finally said she was leaving a little over a year ago. No one really stepped forward to take over except two guys said maybe they could do it part time. One can't remember anything from one minute to the other , and the other one because of work hasn't been at a meeting for months as he works on the night of our meeting. The President use to do the newsletter and programs. I have been doing this , she appointed me! I swear every meeting I wish the female president was back. susan |
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Posted: Thu Feb 21st, 2008 04:09 am |
49th Post |
Lincoln Fan Member
kj3553, I have his card but can't find it at the moment. I know his name was Randy, last name something like Schimmel but not sure. He was accompanying Ralph Borror whom you may or may not know. Ralph does the first person of Abraham Lincoln and they were in town for the annual Dinner with the Presidents we have every year. |
Posted: Thu Feb 21st, 2008 04:24 am |
50th Post |
Basecat Member
Evening all, I have been a member of the CWRT of NY for the past 11 years, and am just finishing my first year as the VP of Programs for the Round Table. Guess my greatest surpise when I was elected to the job was the lack of female speakers we have had here over the years. My goal here when I took this job was that the speakers I got for our meetings would have to know their CW history, and I could care less whether they were male or female. I know I have done that, and the winner of the Fletcher Pratt Award, which is the most prestigious award our Round Table gives out will be awarded to Professor Joan Cashin of The Ohio State University this May. It's a tough job trying to line up speakers, but amidst all the problems I have found myself facing, I am very grateful that many of our members have come up to me and thanked me for the various speakers I have lined up since last September. To me, the big problem facing RTs today is the fact that we can't draw younger folks to join up and be a part of the tradition here, which has been going on for the past 56 years. I am one of the younger members of the RT, and I will be turning 45 this July. I wish I could figure out why there is not more interest in the younger generation in terms of our shared history. Scares me to hell when I think that organizations like the RT here in NY could find itself out of business down the road. Regards from the Garden State, Steve Basic VP of Programs, The CWRT of NY |
Posted: Thu Feb 21st, 2008 05:02 am |
51st Post |
kj3553 Born in the wrong century
Lincoln Fan, I know who you're talking about. Yeah, I've known Randy for a few years. And yes, I know Ralph, too. He used to be affiliated with our RT. And Steve, I hear you about trying to get younger people involved. For the last several years, we've had an "arrangement" with one of our local high schools where there's actually an elective Civil War course for juniors and seniors! Students who are interested in doing so are invited to research a CW-related project and present them at one of our meetings. I had hoped we would pick up some new, younger members through this, but so far -- no go. So I wonder, if you can't get young people who take an elective course on the Civil War to join your group, what do you do next? |
Posted: Thu Feb 21st, 2008 11:38 am |
52nd Post |
ashbel Member
I think all Civil War Round Tables have an older membership. My hope is that this means as people age they develop a greater interest in history. Frankly, I don't lose any sleep over it. My experience has been that if you have good programs, people will come. We really don't care how old they are or what sex they are or what "side" they are on. All are welcome. The only qualifications are a love of history and a desire to learn. |
Posted: Thu Feb 21st, 2008 05:39 pm |
53rd Post |
susansweet Member
ashbel that is how our round table feels too. Everyone interested is welcome. I had three friends I have known on and off since school who kept hearing me talk about round table. They finally decided to see what it was all about. They had not had a previous interest in Civil War history but now they never miss a meeting . They are learning as they attend. Susan |
Posted: Thu Feb 21st, 2008 05:54 pm |
54th Post |
Dixie Girl Southern Belle
thats the way they should be. gender, age, & color should not decide who can join and who cant. ____________________ War Means Fighting And Fighting Means Killing - N. B. Forrest When war does come, my advice is to draw the sword and throw away the scabbard." Stonewall Jackson |
Posted: Thu Feb 28th, 2008 08:31 pm |
55th Post |
Don Member
Susan, If you can use some info for the CW soldiers in the Span-Am (no, Ole, not Spam) War, let me know. Seems like most of the generals served together in the Civil War. Defender, Very nice, but I almost got coffee all over my keyboard. A little warning next time? |
Posted: Thu Mar 20th, 2008 05:09 am |
56th Post |
kj3553 Born in the wrong century
Lincoln Fan, I saw Randy at our March meeting and told him he was famous, having been mentioned on this board. He said to say "Hi!" to you. |
Posted: Sun Apr 27th, 2008 01:23 am |
57th Post |
Widow Member
The Bull Run Civil War Round Table meets at the public library in Centreville, second Thursday of the month, year around. Some of us meet for dinner at a restaurant across the street, but it's unofficial. Most meetings have 40-50 people, special guest speakers like Ed Bearss draw lots more. Our members are well informed and several have written books, but we're not all in that category. Because there are many retired military people in the area, it's not surprising to find them in the RT as well. Our president is a retired colonel, others include a retired skipper of a nuclear attack sub, a retired 4-star USAF general, an astronaut. Two are high-level civilians in the Pentagon. We make several field trips a year, car-pooling from the library. In March we chartered a bus and followed Booth's escape route from Ford's Theater to Garrett's farm. On May 10, we're going to the Wilderness. Dues are $15 a year, "We're cheap but we're proud!" We have a used-book table set up in the back of the meeting room, proceeds go to the RT treasury. We support preservation by donations to CWPT, Brandy Station, and other preservation groups. Maybe even more important, the exec. committee stays well informed about proposed zoning changes, designation of historic sites, road construction, etc. Active participation at hearings in Fairfax and Prince William Counties, lobbying to protect and defend. Most of the members are men, which suits me fine :=)). We're mostly 40 and above. But the women are as gung-ho, active, and informed as the men. I wouldn't miss a meeting for anything. Patty |
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PICTURES: Check out more on the Lea Michelle page
I'm sure you'd have plenty of people ready and willing to take her place between those two. Not to mention the mobs that would be willing to take the boys places too.
Also seen on set were Jenna Ushkowitz, Mark Salling, Harry Shum Jr., Matthew Morrison, Chord Overstreet, Naya Rivera and Heather Morris
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*10 Glee pictures total in the gallery:


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4 de noviembre de 2013


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