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Posted 1 June 2005
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Live Discussion led by John Trojanowski, Les Shaw, and Ann Fagan on 8 July 2005.
Participants: John Ciallella (Cephalon), John Cirrito (Washington University), Clary B. Clish (Gene Logic, Inc.), Keith Crutcher (University of Cincinnati), Chiara Cupidi (University of Palermo, Italy), Mony de Leon (New York University), Anne Fagan (Washington University), Tom Fagan (Alzheimer Research Forum), John D. Fryer (Baylor College of Medicine), Marni Harris-White (GRECC-UCLA), David B. Hawver, pharmacologist (Neurology Drug Products Division, FDA), Rachel Locke (University of Pennsylvania), Patrick Lynn (Satoris, Inc.), Douglas Scharre (Ohio State University), Les Shaw (University of Pennsylvania), Hasan Siddiqi (University of Rhode Island), John Trojanowski (University of Pennsylvania), Diana J. Vincent (Medical University of South Carolina), Nancy E. Lombardo (Boston University).
Les Shaw Hi, Tom.
Tom Fagan We have a few others in the "foyer" about to join us.
Les Shaw Hi, Anne.
Anne Fagan Hi, Les. Nice to "meet" you.
Les Shaw I look forward to the discussion.
Anne Fagan Me, too. So many issues, so few answers at present!
Tom Fagan Anne, what's your major focus these days?
Anne Fagan Lots of exciting things, actually. Antecedent biomarkers are on the top of my list. I'm spearheading a project involving multiple investigators and multiple possible biomarker modalities in middle-aged folks and then following them over time. I'm working with Dr. Cynthia Csernansky, also, in creating a couple of related databases.
Les Shaw Anne, what fluids and what markers?
Anne Fagan I'm the principal investigator (PI) for the cerebrospinal fluid (CSF)/plasma portion, and there is an amyloid imaging section, structural magnetic resonance imaging (MRI) portion, and various clinical and psychological measures, including attentional measures. The great thing is that every subject in our study gets tested for everything. CSF markers include the usual suspects—Aβ(s), tau, phospho-tau, sulfatide, homocysteine, ApoE, cholesterol, some lipoprotein-related measures.
Les Shaw Anne, are the patients cognitively normal and you follow them over time?
Anne Fagan Yes, they are all at clinical dementia rating (CDR) 0 at entry.
Les Shaw Very interesting.
Anne Fagan Since we have a large age range, 45-74, we expect the older CDR 0s to "convert," as it were, quicker. We're recruiting based on positive versus negative family history of AD and can stratify by ApoE genotype also to lump into high/low risk groups to see if anything pops out initially.
Les Shaw Anne, what is the power of ApoE for stratification?
Anne Fagan Les, do you mean literal statistical power? Can't say offhand, but we know that more ApoE4-positive folks will likely go on to develop AD than ApoE4-negative folks, so we hope to enrich for preclinical AD that way.
Tom Fagan Okay, John Trojanowski is here now so we can get started in earnest. John, would you like to start the ball rolling?
John Trojanowski Okay, Tom. Briefly, we will focus here on chemical analyte biomarkers in various bodily fluids such as CSF, urine, blood, etc., and while genetics may come up, too, we will save imaging biomarkers for another time. Back to the question Les raised on ApoE: It does seem to be critical to consider this for cohort assignment as demonstrated in the recent NEJM paper from R. Peterson on mild cognitive impairment (MCI), and we will do this as well in the Alzheimer Disease Neuroimaging Initiative (ADNI) study.
Anne Fagan John, what's your gut feeling about the potential utility of urine showing decent biomarkers?
John Trojanowski So far, urine has seemed fruitful for studies of isoprostanes, although it depends on which one is measured and the method, but I am not certain if other analytes in urine are informative (see related ARF milestone paper by Pratico et al., 2001 on isoprostanes in AD and also papers by Montine et al., 2005 and Bohnstedt et al., 2003 on detection.
Anne Fagan We're already seeing some differences in levels of Aβ42 in ApoE4-positive versus ApoE4-negative folks in our antecedent study, but not other CSF markers, although the data are very preliminary. It suggests that perhaps Aβ42 is the first thing to change. We must verify with follow-up, of course.
Tom Fagan Anne, do you have indications that urine analysis might prove useful?
Anne Fagan Tom, we aren't collecting urine. It may be too far down the line (i.e., processed) to be meaningful, but the idea is very clinically appealing.
John Trojanowski Les, do you have information on other urine analytes?
Les Shaw John, for AD, no.
John Trojanowski Anne, what do the receiver operating curves (ROCs) look like in the studies you mention, and perhaps the group would benefit from a definition of antecedent, as this is not on everyone's radar screen. [ROCs can provide useful information on the sensitivity and specificity of clinical measurements.]
Anne Fagan True, John. We haven't done formal ROC analysis yet. I use antecedent to mean biomarkers that indicate presence of neuropathologic AD (i.e., brain changes) but prior to clinical symptoms. Morris and Price and others at our Alzheimer Disease Research Center (ADRC) have published findings showing that a good percentage of clinically normal elderly folks who die from other causes actually have AD pathology but no clinical symptoms (see, for example, Galvin et al., 2005 and Price and Morris, 1999). Our goal is to be able to identify these folks since clinical variables, by definition, cannot define the presence of preclinical disease. The percentage of "preclinical" subjects is about 30.
John Trojanowski Anne, so antecedent is restricted to prodromal AD as in MCI, or might it be earlier in populations such as those with familial AD (FAD) or Down syndrome?
Anne Fagan Good question, John. I guess Down syndrome would also be considered preclinical, as would FAD cases prior to impairment. They'd be a good population to study. For what it's worth, I consider prodromal to mean prior to any cognitive symptoms, including prior to cognitive symptoms characteristic of MCI.
John Trojanowski I agree with Anne that these analytes are the rising stars for early AD diagnosis with a promise to be useful for sorting out MCI, too, but more work is needed on this, and we need to add a new possibility—lipoxygenase metabolites as per work from Domenico Pratico at the University of Pennsylvania who just had a paper on this (see Yao et al., 2005).
Les Shaw Anne, what will it take to convert to a true diagnostic biomarker in terms of studies and data needed?
John Fryer John, what is the patient population you are collecting from and is it longitudinal?
John Trojanowski The ADNI population is well described in the ADNI website where the redacted grant is publicly available, but briefly, the study is a 3-year longitudinal of 400 MCI, 200 AD, and 200 normal controls balanced for ApoE status. I can add that the Penn Biomarker Core led by Les Shaw and me will perform CSF tau, Aβ, isoprostane, and homocysteine measures, as well as plasma homocysteine and isoprostanes and urine isoprostanes, and we will cover as many species of Aβ, tau, and isoprostanes as we are capable of measuring. Since the data will be made public rapidly, all the ~50 sites participating in this will have access to these data.
Mony de Leon What is the most specific diagnostic CSF marker in AD?
Anne Fagan Mony, currently only autopsy findings are definitive. A number of CSF analytes (Aβ42, tau, perhaps isoprostanes or sulfatide) are promising but so far haven't fulfilled criteria for a true diagnostic biomarker.
John Fryer Has anyone proposed to use an additional patient population, such as Parkinson disease (PD), to determine which changes are specific to Alzheimer's versus neurodegeneration?
Anne Fagan John F., just did some analyses on PD CSF (with and without cognitive impairment). So far, no difference between the groups on our standard CSF analytes (Aβs, tau, etc).
June Kinoshita Anne, to clarify, are you finding no difference between PD with and without dementia, or between AD and PD?
Anne Fagan June, between PD with and without dementia…hot off the press as of yesterday afternoon—not published—not even put into my database yet! And still preliminary, of course. There are differences between AD and PD as perhaps one would expect.
June Kinoshita Anne, at the pathology level, do PD patients with dementia have AD pathology while PD without dementia have no AD pathology? I imagine it is not quite so clear-cut, but it's interesting that you don't see differences at the biomarker level.
Anne Fagan June, these samples are from a big bank in Rochester. I don't think any autopsy information is available. I'll have to check on that.
John Trojanowski John T agrees with Anne and adds that Lewy body variant of AD (LBVAD) may be possible to distinguish from PD or PD with dementia (PDD) by the AD biomarker profile of CSF tau, Aβ, and isoprostanes, but I do not know about sulfatides, which I neglected to mention also is on the roster of analytes the ADNI Biomarker Core will examine in CSF.
Anne Fagan John T, we're still working out some methodological bugs with sulfatide, but our published data were very promising and warrant exploration. Glad to hear you're doing that.
John Trojanowski Okay, Anne, and we had input from folks at Washington University on how to do the sulfatide assays, and these data also will be made public on the ADNI website within a few months of study completion.
Anne Fagan Another issue is ultimate ease of measurement. It seems like some of the metabolites and various other things are measured by labor-intensive methods such as high-performance liquid chromatography (HPLC). I guess we need to find the marker first and then hone down the measurement issues.
John Trojanowski While some of these tests are labor-intensive, Les does mass spectrometry measurements on many analytes other than for AD, so perhaps he can give a sense of labor, costs, and turnaround for this type of measurement as they are routine in some pathology and laboratory medicine diagnostic units.
Tom Fagan All, given the potential labor required, is cost a major impediment to validating biomarkers?
Anne Fagan Tom, I don't think cost should be an issue yet, but it will be ultimately as things are taken to the clinic.
John Trojanowski I do not think this is a problem, Tom, but if we have not lost Les, he can weigh in here as this is an area he has expertise with in lab diagnostics.
Les Shaw Most major medical centers and clinical labs have mass spectrometry equipment and expertise for certain types of tests—toxicology, drug monitoring metabolic diseases. Once the equipment and the expertise to run these is in place, the costs are very competitive compared with costs for immunoassays, for example, and that type of cost is reasonable. I foresee more mass spectrometry applications, for example, the low molecular weight biomarkers once clinically validated coming into routine practice in the future.
Tom Fagan Anne, what about enrollment numbers? Is ADNI or your study sufficiently powerful enough statistically, or will a broader net need to be cast, eventually?
Anne Fagan Tom, the answer for our study is likely no. A wider net would be good. Even though we defined our enrollment numbers according to proper power calculations, I predict greater numbers will eventually be needed, especially if the effect is relatively small, as one would perhaps predict in a preclinical disease state—nature of the beast, and all.
Anne Fagan Patrick, we haven't looked carefully at plasma yet, although we collect it (fasted) so we can go back at any time as interesting possibilities emerge. Tough to work with, given all the proteases, etc.
Hasan Siddiqi How about using SELDI-TOF (surface-enhanced laser desorption and ionization-time of flight) mass spectroscopy to look for novel biomarkers in plasma?
Anne Fagan SELDI-TOF is certainly a possibility. I predict biomarkers that mark brain processes will be in low abundance, especially in plasma/serum. Tough to do, though.
Les Shaw Mass spectroscopy methods for certain drugs and toxins, for example, and metabolic diseases are now fairly standard for routine or semi-routine testing. Most drug study method validations using mass spectroscopy and using it for the clinical trials is now what is typical, and I foresee this more and more for many of the biomarkers we are interested in for AD. What is needed more than anything, for the methodology part, is lab-to-lab comparisons and standardization.
June Kinoshita Hear, hear!
Tom Fagan Les, what is being done to standardize among different labs? I would imagine this must be one of the major aims of the ADNI, right?
Anne Fagan Standardization will be a major issue, dare I say, problem?, and one that must be attacked head-on at the inception of studies, if possible.
John Trojanowski To add to what Les mentions, this standardization is a major effort and focus of the Biomarker Core which will interact with pharmaceutical companies and diagnostic companies to make the best academic/industry standards for the analytes that we measure. So we are hopeful that CLIA-approved AD diagnostics will come out of this effort 3-5 years hence. (CLIA, or Clinical Laboratory Improvement Amendments, is a branch of Centers for Medicare and Medicaid Services that regulates all laboratory testing carried out on humans in the US.)
John Fryer John T. and Anne, how often are your patients imaged and does the imaging include amyloid imaging agents?
John Trojanowski John F., the imaging is magnetic resonance imaging (MRI) and positron emission tomography (PET) at different schedules for the different cohorts. No imaging ligands are part of this study.
Anne Fagan John F, our studies include MRI as well as Pittsburgh compound B (PIB) PET (see ARF related news story). Imaging will be done over time but I can't recall offhand the intervals. I know CSF will be taken every 3 years. Perhaps it will be the same for imaging. I'll have to go back to the grant to be sure.
John Trojanowski In ADNI, there is no PIB, and the CSF is to be from ~30%-50% or more of all subjects obtained at baseline and after 1 year. Other fluid draws are more frequent and over longer periods of the study, and this, too, is all available on the ADNI website by accessing the grants.
Hasan Siddiqi Does anyone think the biggest issues with plasma biomarkers is specificity/sensitivity in relation to CSF biomarkers?
Anne Fagan I don't have a feeling for that, Hasan.
Clary Clish Hi, I am Clary Clish from Gene Logic, Inc. I am developing a liquid chromatography-mass spectrometry (LC-MS)-based biomarker analysis platform for a wide range of disease states including AD.
Tom Fagan Clary, can you give us some idea of the scope of your project, how many patient samples, etc.?
Clary Clish My efforts are focused on small, endogenous molecules and I am just getting started on AD. Method development is going to begin with CSF, plasma, and urine samples from preclinical subjects. We are going to target compounds that are in some way tied to the pathophysiology and potentially dysregulated.
Anne Fagan For what it's worth, we've also begun a CSF proteomics project using two-dimensional difference gel electrophoresis (2D-DIGE)-based methods combined with LC-MS. A fishing expedition but one that we hope will pay off down the line.
June Kinoshita I love fishing expeditions, Anne. Most, dare I say all?, of the biomarker candidates that are being looked at are based on studies in AD patients. How do we know that the same biomarkers will indicate the presence of preclinical stages? What do you all think about casting a wider net and carrying out some proteomic and genomic fishing expeditions? Good idea or waste of dollars?
Anne Fagan June, our efforts on antecedent biomarkers dovetail nicely with our work on AD subjects. We also are collecting CSF/plasma from very mild and mild AD cases. Maybe I'm naïve, but I think that what one finds in clinical AD will probably be found earlier—just depends how far back we can detect the change. Does that make sense?
June Kinoshita Yes, it does.
Anne Fagan Also, June, proteomics projects are tough to get funded (I should know!) for just that reason—they are too "fishy," especially with the present NIH funding situation.
John Trojanowski Further on ADNI, while the analytes we measured were chosen with their potential promise to be informative (based on published reports) and budget in mind, there are opportunities of add-on studies to the ADNI biomarker work, and folks interested in this should check the ADNI website or the public announcement (.pdf) that appeared on the NIA website last year. But realize that requests for add-on studies are vetted by a resource allocation review committee (RARC) of advisors to ADNI and it will not be possible to apply to duplicate studies of analytes already covered by the ADNI proposal.
Anne Fagan John T, I'm sure you've thought about data management for the ADNI. Do you have someone that is spearheading this specific part? I, unfortunately, could not attend the bioinformatics meeting in Washington, DC, a few weeks ago.
John Trojanowski Anne, the data collection is in the petabyte domain of intensity, and it is coordinated by the Clinical Core at UCSD under the direction of Leon Thal in collaboration with Art Toga at the laboratory for neuroimaging (LONI) at UCLA. This is all Web-based, and data mining will be possible by frequent postings of data on a public website at the ADNI website. And, June, focused fishing will be possible through add-on studies to ADNI as mentioned above, but funding for this will be through competitive grant applications, following approval by the RARC, to access banked ADNI biosamples.
Anne Fagan John T, will people be able to download data and use them at their discretion or will there be some guidance/policing of who does what with what data?
John Trojanowski Anne, yes, this will be possible with approvals, access codes, etc., and the data will be de-identified, but the idea is to encourage data mining and publication with consultation with an ADNI publication committee.
Anne Fagan John T, a publication committee is a great idea.
John Trojanowski Further on Anne's query about data management, an attractive aspect of the ADNI is the fact that all data, clinical, biomarker, imaging, etc., will be made public so bioinformatics and biostatics gurus can mine the data for developing better data analysis tools and new correlations, etc. My question to Anne is: Will the data collected in the study she mentions be made public and can investigators apply to add-on studies to examine aliquots of the biosamples collected for this new study?
Anne Fagan Also, to answer your question, John T, we are in the process of developing a relational database for our antecedent study (termed ACS for Adult Child Study) for in-house analyses…tricky to even coordinate 4-6 investigators within the project, let alone between institutions. Hopefully this proof-of-principle database can then be adopted by other institutions for their own in-house analyses. Ultimately, we will make the data public but there are some important issues that need to be addressed first, such as what I just brought up: how to make sure that the data are "used" appropriately, for lack of a better word. And yes, our samples will certainly be available to other investigators through our usual (competitive) tissue request and review process. Information can be found on our ADRC website.
John Ciallella Is anyone tracking blood glucose as a biomarker, given a possible link between diabetes and AD?
Anne Fagan Great question, John C. We have not proposed to test blood glucose, but certainly could do so with appropriate collaborations. The AD/insulin/diabetes connection is very interesting to me, although I'm just learning about it. [See related ARF Live Discussions: Is Alzheimer's a Type 3 Diabetes? led by Suzanne de la Monte and Insulin Resistance: A Common Axis Linking Alzheimer's, Depression and Metabolism? led by Natalie Rasgon.]
Nancy E. Lombardo Earlier this week during the AlzForum chat on insulin resistance, AD, and depression, Suzanne de la Monte, Natalie Rasgon, June, myself, and others were wondering whether the current leading studies of biomarkers for AD, including the National Institute on Aging (NIA) neuroimaging study, are including biomarkers for insulin resistance, especially in the brain.
John Trojanowski Nancy, this is not covered in the ADNI Biomarker core list of analytes to be studied at the University of Pennsylvania, and we selected analytes, the ones mentioned above, with budget limitations in mind, but others can pursue studies of other analytes through the ADNI add-on study mechanisms, and funding for this must be obtained by the investigators wishing to study the other analytes, so there are mechanisms in place for hypothesis-driven as well as exploratory metabolomic, proteomic, and other "omic" approaches. Since the samples are precious and limited, the RARC will adjudicate who will gain access to samples. Also, a certain percentage of the aliquots will be held in reserve until the end of the ADNI grant to enable us to take advantage of new technologies that emerge in the next few years.
Tom Fagan All, someone mentioned familial AD (FAD) earlier, but I think I missed the gist, so is anyone following FAD patients in preclinical stages?
Anne Fagan Tom, we are not following FAD families. Alison Goate here at Washington University is doing some genetic studies with them. It would be great to get CSF/plasma but these families are all over the world. Again, it brings up the issue of variability in sample collection and analysis protocols between labs.
June Kinoshita Tom regarding FAD subjects, there is one study that I know of with individuals who are positive for an FAD mutation and have not developed symptoms yet. I think there are more people out there who would volunteer if we could only find a way to connect with them. That's where the early-onset AD (EOAD) Web page idea comes in.
Tom Fagan June, yes, that was one of the things on my mind! It also occurs to me that many FAD patients might be slightly scared to get involved, for fear of finding out the worst, but as treatments start to become available, they might be more inclined.
Anne Fagan June, what's the EOAD Web page idea?
June Anne, the idea of the EOAD Web page is to set up an informational page on the Alzforum directed to people with early-onset AD in their families and for researchers who are interested in working with them. They have some different medical needs and issues, for example, genetic counseling, family issues, etc., and might benefit from support and advice from other EOAD families. They also may have a very high level of motivation to participate in research because their children may have the mutations. So an EOAD online community would support patients and families and also nurture alliances between affected individuals and researchers.
Anne Fagan June, great idea with the FAD families. I love AlzForum!
June Thanks, Anne!
John Fryer Anne, how long is this longitudinal study currently funded for?
Anne Fagan John F, the study just got funded for 5 years—not enough time to do any validation, of course, but we hope it will continue for many years!!
Hasan Siddiqi I heard that some group recently found another type of plaque associated with AD…not too sure on the specifics. Anyone have more information on this?
Anne Fagan What do people think about the concept of incentives for researchers to adopt certain collection and analytical procedures in order to better compare data between labs? Too controlling? I think one of the big problems with biomarker, especially antecedent studies, is lack of enough statistical power. How can we as a scientific community pool our resources (samples, data, etc.) to move forward at a more rapid pace?
Les Shaw Anne, that's a good way to bring up the importance of the collection and procedures standardization needs. I think building the spirit of collaboration and promoting this is key.
Anne Fagan Les, I agree whole-heartedly.
Clary Clish Anne, I think your idea about standardization, particularly for sample collection and storage, is a good one. The analytical protocols that follow afterward are more challenging as they may be hardware-dependent.
Anne Fagan I absolutely agree with you, Clary. Even in my own project we use two different protocols to measure Aβ42. While the values are highly correlated, they are not the same, and that's using the same experimenter and the exact same samples!
Les Shaw Further to collaboration, too, I believe we in academia benefit a lot from engaging with our pharma colleagues who bring certain strengths to the table like issues of standardization since they have FDA hoops to go through for drug studies.
John Fryer John, how comprehensive is the neurological examination of your patients over time and will this be on the ADNI Web posting also, or will HIPAA regulations prevent that (see related Live Discussion on the impact of the Health Insurance Portability and Accountability Act (HIPAA) on research)?
John Trojanowski John F, there is not enough room here to mention the inclusion/exclusion criteria to be used at the ~50 participating ADNI sites, but these are available for identifying normal, MCI, and AD patients in the ADNI grants that are available to the public at the ADNI website, and moreover, the SOPs for all of the studies to be done including biomarkers, which was an amazing accomplishment by Les Shaw, will go up on the ADNI website too, so we hope that others will take advantage of this public access to ADNI data and study design as we all go forward with biomarker studies for AD as well as related dementias such as frontotemporal dementias (FTDs), Parkinson disease with dementia (PDD), etc.
Hasan Siddiqi Is tau a current neuroimaging target?
Tom Fagan Hasan, I don't believe there are any ligands yet that are useful for tau imaging, but there was a paper recently on natural tau fluorescence, but no indication that this might be useful in vivo (see Bing et al., 2005).
June Hasan, I believe Gary Small at UCLA has been working on tau imaging ligands.
Tom Fagan Oops! Okay, June trumps me with Gary's studies.
June Don't hold me to it, though!
Tom Fagan Okay, folks, we are nearing the end of our scheduled hour, but please feel free to continue chatting as long as you wish. But before people start drifting off, I just wanted to thank John, Les, and Anne for agreeing to devote some of their valuable time to this chat.
John Fryer I have a meeting, best of luck to you all.
John Trojanowski Okay, and please all check the ADNI website periodically for new items on progress, data, and other options to make use of the incredible amount of data that will flow from ADNI and will benefit from analysis by many investigators including those beyond the ADNI investigators. With that, I say ciao to all until next time.
Anne Fagan Thanks to everyone for an animated discussion! Hopefully this will be the first of many.
June Ciao, John. Thanks, Anne and Les!
Les Shaw Goodbye, all.
Anne Fagan Thank you, June. Wish I could type better!


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Should American law protect unborn children from harm?
Bob Beckel debates O'Reilly on protecting the unborn from drugs and abortion
Feb 20, 2013
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I reaction -- error because of the five Bob that.
I said the Jersey ruling first you understand it yeah I understand it and I do it being a recovering alcoholic -- addict I understand completely what is -- crack baby and I've seen him before.
They made a decision -- -- evidence we don't have here but if this child hadn't toxicology reports showed some cocaine in his system.
That means that they weren't crack baby a crack babies -- born addicted to crack.
If you put somebody who if you took away a child from everybody who used illegal drugs.
Before their pregnancy you're going to be taking hundreds of hunch without -- and Colorado and Washington State people use drug.
Us a lot of people -- this all right -- you you are okay with a country.
Saying to mothers you can take heroin cocaine methamphetamine.
OxyContin anything two days before giving birth.
And we are not gonna hold you accountable at all you'll get a hold you accountable if our child if their child has damaged and -- overall out of the an excuse you are.
I've talked about this -- this ruling back all fine.
This society in New Jersey did not hold this woman accountable for this action.
-- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Until that -- what you wanna do you wanna take this child had put a -- -- a terrible well here's what I wanna do for here's a fair thing to do you take the -- child away from the money you put it in the system.
And -- drug test some other than thirty days and see what condition -- -- in.
And then if the mother's -- you return the child.
That's the same thing to do and you might consider charging the mother with a crime because to legal to smoke crack cocaine.
Any time.
Anywhere that's it but you know the Foster system you've seen -- I'm not getting justify the Foster system I'm saying this woman.
Nothing happened in a civilized fair society.
This is wrong there and then it's gone wrong hundreds and is it the courts are -- it's wrong but so we have to deal with it from their mother yet the thirty -- -- the woman's a crack addict that's -- you do well.
Okay now.
Cuomo in New York.
Open season -- -- birth until birth.
He wants no restrictions on late term abortion at all.
You said.
That's his that's ridiculous on in the first trimester is about personal I am to be.
Against abortions are not in the position to tell -- what I usually that try to try to trimester is about as far as I'm in that regard.
You say you disagree with Cuomo yes that now.
Again we go back to our society I think we're living in a barbaric society in America I think we've come Bob become -- -- here.
The way we treat our elderly horrible.
Horrible the way we treat the unborn awful.
All right and all of these policies are promoted by people like Andrew Cuomo.
On the left you don't see the right promoting these policies does that disturb you -- laws -- This is that talking when -- more years last.
And I tell you are frozen the -- by this judge -- -- that you predicted that the fact it's changed.
And you -- it hasn't changed for the better I think it has changed that in many ways for example education you jump and that's -- -- 260% -- -- They're Smart kids today they've been on the test -- that just that Ramadan is dead wrong.
There we never tested for math and science when we do now and we increasing their ability to both those errors.
The idea about welfare.
It's 14%.
Of what it wasn't federal budget in 2002 it's 14% today it doesn't make any difference because a federal budget is all high today yes all right so the deal not a dollars is -- much more and because we're seventeen trillion in my head.
That he is high it's not a good move waging war we should have been waging one children -- Social Security Medicare that are out of control let's Kodak to deal with -- let's get back to the barbaric society that I think we have here now.
It's a narcissistic society heard Andrew Cuomo say your body your decision your body your decision it's all about the -- so that you -- right.
You say I was fairly grounded in the fifties what was wrong beside the civil rights stuff which which was and I pointed out last -- did all right which was definitely.
What was wrong with the values that we had in the fifties of honesty hard work and suffer line I think the assumption that those are not values today is just absolutely an indictment -- you have.
I know that based on you know -- facts on your part you don't think that we you have more Americas today one handouts and you do back then I think you have people today think you have more Americas today one hand you like you have more people getting -- that yes wanting handouts no I actually get up because they had no choice now but I think this is what about disability.
Does a good people are disabled -- disable so it's disabled and the right to have that self.
It's 60%.
More dangerous today.
212 and it was 2000 -- you have so that he or is that is it 60% more gators today that was in 2000 had a major recession in the -- -- -- that I don't know what their ability today.
That's disability disability more more people finding access to disability that's right and -- why can't because the law says they can't.
It's making it easier for them here disabled should not be able to.
That's just disability because you don't think -- is we think they're all this at all I think most of reduce at most some I think there's probably some -- -- but not all of it and what.
Well you know you're -- last night about.
You know this great America in the fifties when we're that we fought the -- we heard drag him to fight and that's what -- that the British do alone if we had been attacked my deputy Pearl Harbor -- -- -- dismissed.
About this last generation EO Tom -- the greatest generation the fact that matters around.
I -- -- we're -- together well but yet on the -- renting them.
-- yeah I'm really got that's strange coming from you.
-- --
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Watch Brad Pitt Go from 20-Something to 50 in Seconds
omg!11 hrs agoBrad Pitt may turn 50 on December 18, but he's still looking fine! For more than two decades, The "World War Z" star has charmed us with his philanthropic ways, his talent, and — you know, what's really important — his pretty face. There are his enchanting blue eyes, his sparkling smile that makes us jealous of Angelina, and then there's the hair, which he changes just often enough to keep our long-term relationship interesting. To celebrate his half-century birthday, let's take a look back at the many ways he's worn his locks over the years.
Hollywood Gets Photobombed
Hallie Stephens at omg!12 hrs agoHollywood's biggest stars are getting photobombed left and right by other celebs! Back in April, Kevin Spacey gave his best evil eye behind an unsuspecting Conan O'Brien and Matthew Perry, who were busy smiling for the cameras at the Vanity Fair-Bloomberg White House Correspondents' Association dinner afterparty.
And in May, Tinseltown's cutest couple got even more playfully adorable when Emma Stone made a wide-eyed silly face behind her beau, Andrew Garfield, as he posed for a pic.
In 2008, Joey Fatone flashed a cheeky grin behind Lisa Rinna as she posed on the red carpet at the Emmys, and Angelina Jolie and Catherine Zeta-Jones were all smiles at the 2011 Golden Globes, not realizing that Michael Douglas was crashing their picture-perfect moment.
Check out the vid to see which other A-listers got bombed, and be sure to tune in to "omg! Insider" on TV tonight for the latest in entertainment news.
Did Kim Kardashian Wax North West's Eyebrows?
omg!14 hrs agoCan't someone upload a photo on Instagram without a side of controversy anymore? On Monday, Kim Kardashian, 33, shared a close-up picture of her 6-month-old daughter, North West. The photo, which was captioned "SMILE," showed Nori's adorable brown eyes, rosy cheeks … and waxed eyebrows?! Many of Kardashian's haters thought the baby's brows were too perfectly groomed to be natural.
Does Kim kardashian wax her baby's eyebrows orrrr Referring to her insta pic
Is it me or did Kim Kardashian wax NW's unibrow
I'm not even kidding I think Kim Kardashian waxed her daughter's eyebrows
Kim K definitely waxed her baby's unibrow
(You get the idea.) A lot of blogs took it from there, insinuating that must indeed be the case. This, of course, prompted a response from Kim herself on Tuesday.
Do people really think I would wax my daughters eyebrows so young? Come on, I'd wait until she's at least 2 1/2!
I'm kidding!!! Its pretty sick for people to insinuate that I would wax my daughters eyebrows. They are thick, natural and amazing!
Connecting! Kelly Rowland Gets Engaged on Skype — and Other Non-Traditional Celeb Proposals
omg!15 hrs agoKelly Rowland and her fiancé were oceans apart when they became engaged.
"The X Factor" judge revealed that when Tim Witherspoon, who is also her manager, popped the question he did so on Skype while she was traveling in Bulgaria. After he proposed to her on screen during the Internet call, Rowland revealed on "The Queen Latifah Show" that she initially resisted, saying, "'We're so far away from each other.'"
But in the end, she couldn't turn him down. "It was so late and we were both ... staring at each other," she recounted. "It was just that simple to say yes. I was like, 'I got my best friend to ride through life with.' He really is my best friend."
As is the case with regular folks, not every marriage proposal takes place picture perfectly — on bended knee at the top of the Eiffel Tower (where Tom Cruise asked for Katie Holmes's hand) or during a breathtaking helicopter ride over Chicago to look at Christmas lights (how Bill Rancic swept Giuliana Rancic off her feet). Several others have gone the non-traditional route, too.
Rihanna Rocks Denim-on-Denim Outfit in New Balmain Campaign
omg!15 hrs ago'Tis the season to become the face of a fashion house! Last week, Kristen Stewart was announced as the new face ofChanel's Paris-Dallas collection, and on Tuesday, a Balmain campaign featuring Rihanna went live.
She tweeted the news, linking to a picture from the campaign featuring a surprisingly covered up RiRi mugging for the camera in a white-tiled room wearing a denim off-the-shoulder shirt with chain detailing and matching blue jean pants.
Guess who's the new BALMAIN Woman???!!!!!!! #BALMAIN #MommaImadeIt #CaribbeanGalRunTing @orousteing http://t.co/o0GkCydzJc
Bradley Cooper Opens Up About How Drug, Alcohol Addiction Affected His Career
Hallie Stephens at omg!17 hrs agoBradley Cooper can certainly play an addict convincingly on the big screen, but the actor has admitted to having trouble with drugs and alcohol in real life, too, and he's not afraid to talk openly about it.
The Hollywood hunk first admitted his addiction struggles to the Hollywood Reporter back in 2012, but now he's revealing even more about his battle in the January 2014 issue of GQ magazine, saying, "If I continued it, I was really going to sabotage my whole life."
The "American Hustle" star said that while he was never late or absent from work, he thought his performance was suffering as a result of his drug use. "I think work was getting f----- up…the best thing I can do is embrace who I am and then do that to the fullest extent, and then whatever happens, happens," he said. "The more steps I do to not do that, the farther I am away from fulfilling any potential I would have…so yes, of course it hindered my work."
Watch the video for more on this story and to find out what the 38-year-old admitted about one of his darkest moments. And be sure to tune in to omg! Insider on TV tonight for all the latest in entertainment news.
Colin Farrell: Elizabeth Taylor Feels Like My Last 'Romantic Relationship'
omg!18 hrs agoCould Colin Farrell have been Elizabeth Taylor's eighth husband? In another life, quite possibly! The "Saving Mr. Banks" star was one of the few non-family members invited to Taylor's funeral in 2011, which had many wondering what the connection was between the two. The two were so close in fact, that Colin recited a poem at the one-hour service. Farrell, 37, just opened up about their relationship on "The Ellen DeGeneres Show." "My youngest son was being born. We were in Cedars [Sinai hospital] and I bumped into … Elizabeth's manager and her close friend Tim Mendelsohn and they said, 'What are you doing here?'" Colin recalled.
Sara Bareilles Helps 4-Year-Old Cancer Patient 'Be Brave'
Sarah Flanigan at omg!21 hrs agoA 4-year-old cancer patient received VIP attention when Sara Bareilles invited him up on stage for a duet while playing at House of Blues Orlando on her U.S. tour.
Joshua Chamber, who was diagnosed with leukemia last February and is now in remission, has a Facebook page entitled "Joshua's Journey — Be Brave" inspired by Sara's tune, so imagine his surprise when she let him jump in on his self-proclaimed theme song!
"Josh is one of the bravest little angels I've ever met, and he asked if he could come on stage and sing with all of you!" she told the crowd.
Not only did little Joshua sing, he did so like a pro. His delivery of the line "I want to see you be brave" was possibly the cutest rendition ever.
While Katy Perry's "Roar" has also become a battle cry for young cancer patients, the lyrics in "Brave" seem to fit perfectly for Joshua and it's no wonder it's his theme song.
'Luckiest Man' Indeed: Jay Sean and Wife Welcome a Baby Girl!
Jenny Depper at omg!21 hrs agoJay Sean is definitely the "Luckiest Man."
The 32-year-old performer joined the daddy club on Dec. 13 when his wife, Thara Natalie, gave birth to their first child, daughter Ayva Loveen Kaur Jhooti.
The British R&B crooner shared the happy news with his fans via Instagram on Monday, and gushed that his little lady was happy and healthy.
"Yuuuuup! I'm a daddy!!!!! Meet our lil baby girl, Ayva. She was born on the 13th December, weighing in at 6pounds 7ounces. It was the most incredible moment of my life seeing her enter this world."
And according to Sean, his baby girl is already a fan of his music. "Wifey @tharanatalie (who was unbelievably strong and composed thru it all btw- yogamommy!!) had a music playlist for her delivery - a mixture of diff artists and some of her fav songs - (including mine!) Would u believe of all the songs on the playlist she was born to daddy's song!!?!!! She was born to 'Luckiest Man.'"
Sean, who was born Kamaljit Singh Jhooti, also said that he plans on bringing his bundle of joy on the road with him so all of his fans can meet the littlest member of his crew.
Paul Walker's Death Certificate Released
omg!21 hrs agoPaul Walker's official cause of death has been determined.
The "Fast & Furious" star's death certificate has been issued and it states that he died from "combined effects of traumatic and thermal injuries."
The document, which was obtained by "omg! Insider," was issued on Dec. 16. It also notes that the star, whose full name is listed as Paul William Walker IV, died during an "accident" on Nov. 30, sustaining his fatal injury on the "street" when the car he was riding in hit a "fixed object" in Santa Clarita, California.
The phrasing "combined effects of traumatic and thermal injuries" was the same wording used when the Los Angeles County Coroner's Department released their autopsy findings on Dec. 4.


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It will take a lot more than some racist tweets to bring Sebastien down.
The "boy with the golden voice" tweeted earlier today: "Please do not pay attention to the negative people. I am an American living the American Dream. This is part of the American life."
Sebastien said today was like any other day, but he's always grateful to wake up to yet another day able to sing. He said he owes his positive outlook to his parents, family and everyone in San Antonio.


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[Resolved] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
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Topic: [Resolved] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out (Read 3174 times)
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Posts: 7
[Resolved] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
December 13, 2011, 09:07:03 am »
Hello there!
Recently I have been having a bit of trouble with my PC, and it has now gotten to the point where I'm ready to throw it out the window
Anyway, let's begin with the issues. First, when I start my computer, NOD32 always pops up saying this exactly: MBR sector of the 0. physical disk - Win32/Agent.SDG.Gen trojan - action selection postponed until scan completion
Try to clean, and it fails. I'm not too sure how bad it is.
Another big issue I've been having is that my internet connection constantly times out by itself. I can load a few pages fine, and then I'm disconnected. To reconnect, I have to do a cmd /release and /renew, which then only lasts a few more pages. I have tried: calling my ISP (Comcast), getting modem replaced, connecting directly (I do use a Linksys router), resetting Linksys options to factory default, changing ethernet cables, etc.
Note: All wireless connection are always fine, and they never get dropped. It seems to only be me, and I wasn't sure if it was due to a virus?
Here is my log:
Logfile of Trend Micro HijackThis v2.0.4
Scan saved at 9:58:06 AM, on 12/13/2011
Platform: Windows XP SP3 (WinNT 5.01.2600)
MSIE: Internet Explorer v8.00 (8.00.6001.18702)
Boot mode: Normal
Running processes:
C:\program files\Creative\Shared Files\CTAudSvc.exe
C:\Program Files\Common Files\Apple\Mobile Device Support\AppleMobileDeviceService.exe
C:\Program Files\Bonjour\mDNSResponder.exe
C:\Program Files\ESET\ESET Smart Security\ekrn.exe
C:\Program Files\iWin Games\iWinTrusted.exe
C:\Program Files\Java\jre6\bin\jqs.exe
C:\Program Files\Common Files\LogiShrd\LVMVFM\LVPrcSrv.exe
c:\program files\grasssoft\mouserecorder\MacroService.exe
C:\Program Files\NVIDIA Corporation\nTune\nTuneService.exe
C:\Program Files\Google\Update\220.127.116.11\GoogleCrashHandler.exe
C:\program files\Creative\Sound Blaster X-Fi\Volume Panel\VolPanlu.exe
C:\Program Files\Analog Devices\Core\smax4pnp.exe
C:\Program Files\Logitech\GamePanel Software\LgDevAgt.exe
C:\Program Files\Logitech\GamePanel Software\LCD Manager\lcdmon.exe
C:\Program Files\Logitech\GamePanel Software\G-series Software\LGDCore.exe
C:\Program Files\ESET\ESET Smart Security\egui.exe
C:\Program Files\Unlocker\UnlockerAssistant.exe
C:\Program Files\MarkAny\ContentSAFER\MaAgent.exe
C:\Program Files\Common Files\Real\Update_OB\realsched.exe
C:\Program Files\Logitech\GamePanel Software\Applets\LCDClock.exe
C:\Program Files\Logitech\GamePanel Software\Applets\LCDMedia.exe
C:\Program Files\Logitech\Logitech WebCam Software\LWS.exe
C:\Program Files\Logitech\GamePanel Software\Applets\LCDPop3.exe
C:\Program Files\Microsoft Office\Office12\GrooveMonitor.exe
C:\Program Files\Windows Live\Device Manager\msgrdvmn.exe
C:\Program Files\iTunes\iTunesHelper.exe
C:\Program Files\Ask.com\Updater\Updater.exe
C:\Program Files\Lexmark S300-S400 Series\lxeamon.exe
C:\Program Files\Lexmark S300-S400 Series\ezprint.exe
C:\Program Files\Common Files\Java\Java Update\jusched.exe
C:\Program Files\Logitech\Z-5 Speakers\Z-5 Speakers.exe
C:\Program Files\Windows Live\Messenger\msnmsgr.exe
C:\Program Files\Mnet\QuickManager2\MRDaemon.exe
C:\Program Files\Pando Networks\Media Booster\PMB.exe
C:\Program Files\Common Files\Logishrd\LQCVFX\COCIManager.exe
C:\Program Files\iPod\bin\iPodService.exe
C:\program files\Logitech\SetPoint\SetPoint.exe
C:\program files\Xfire\Xfire.exe
C:\Program Files\Common Files\Logishrd\KHAL2\KHALMNPR.EXE
C:\program files\Mozilla Firefox\firefox.exe
C:\Program Files\Windows Live\Contacts\wlcomm.exe
C:\Program Files\Windows Live\Messenger\wlcsdk.exe
C:\program files\Mozilla Firefox\plugin-container.exe
C:\program files\Mozilla Firefox\plugin-container.exe
C:\Program Files\CCleaner\CCleaner.exe
C:\Documents and Settings\Chaddie Dimiati\Desktop\HijackThis.exe
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page =
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL =
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL =
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page =
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page =
R1 - HKCU\Software\Microsoft\Windows\CurrentVersion\Internet Settings,ProxyOverride = *.local
R3 - URLSearchHook: SHOUTcast Toolbar Search Class - {14f0d511-36a2-41ca-ae01-ba4f87282c97} - C:\Program Files\SHOUTcast Radio Toolbar\shoutcasttb.dll
R3 - URLSearchHook: XfireXO Toolbar - {5e5ab302-7f65-44cd-8211-c1d4caaccea3} - C:\Program Files\XfireXO\prxtbXfi2.dll
O2 - BHO: btorbit.com - {000123B4-9B42-4900-B3F7-F4B073EFC214} - C:\Program Files\Orbitdownloader\orbitcth.dll
O2 - BHO: Lexmark Toolbar - {1017A80C-6F09-4548-A84D-EDD6AC9525F0} - C:\Program Files\Lexmark Toolbar\toolband.dll
O2 - BHO: AcroIEHelperStub - {18DF081C-E8AD-4283-A596-FA578C2EBDC3} - C:\Program Files\Common Files\Adobe\Acrobat\ActiveX\AcroIEHelperShim.dll
O2 - BHO: RealPlayer Download and Record Plugin for Internet Explorer - {3049C3E9-B461-4BC5-8870-4C09146192CA} - C:\Documents and Settings\All Users\Application Data\Real\RealPlayer\BrowserRecordPlugin\IE\rpbrowserrecordplugin.dll
O2 - BHO: Conduit Engine - {30F9B915-B755-4826-820B-08FBA6BD249D} - C:\Program Files\ConduitEngine\prxConduitEngine.dll
O2 - BHO: XFINITY Toolbar - {4b9bcce8-a70b-402a-a7e1-db96831ee26f} - C:\Program Files\xfin_portal\comcastdx.dll
O2 - BHO: (no name) - {5C255C8A-E604-49b4-9D64-90988571CECB} - (no file)
O2 - BHO: XfireXO - {5e5ab302-7f65-44cd-8211-c1d4caaccea3} - C:\Program Files\XfireXO\prxtbXfi2.dll
O2 - BHO: Groove GFS Browser Helper - {72853161-30C5-4D22-B7F9-0BBC1D38A37E} - C:\Program Files\Microsoft Office\Office12\GrooveShellExtensions.dll
O2 - BHO: IEHlprObj Class - {8CA5ED52-F3FB-4414-A105-2E3491156990} - C:\Program Files\iWin Games\iWinGamesHookIE.dll
O2 - BHO: Windows Live Sign-in Helper - {9030D464-4C02-4ABF-8ECC-5164760863C6} - C:\Program Files\Common Files\Microsoft Shared\Windows Live\WindowsLiveLogin.dll
O2 - BHO: Updater For XFIN_PORTAL - {bb46be07-13eb-4c49-b0f0-fc78b9ea4983} - C:\Program Files\xfin_portal\auxi\comcastAu.dll
O2 - BHO: SHOUTcast Loader - {ccec60fc-2608-4e58-9659-3ffc159e8ea9} - C:\Program Files\SHOUTcast Radio Toolbar\shoutcasttb.dll
O2 - BHO: Ask Toolbar BHO - {D4027C7F-154A-4066-A1AD-4243D8127440} - C:\Program Files\Ask.com\GenericAskToolbar.dll
O2 - BHO: Java(tm) Plug-In 2 SSV Helper - {DBC80044-A445-435b-BC74-9C25C1C588A9} - C:\Program Files\Java\jre6\bin\jp2ssv.dll
O2 - BHO: Google Gears Helper - {E0FEFE40-FBF9-42AE-BA58-794CA7E3FB53} - C:\Program Files\Google\Google Gears\Internet Explorer\0.5.36.0\gears.dll
O2 - BHO: JQSIEStartDetectorImpl - {E7E6F031-17CE-4C07-BC86-EABFE594F69C} - C:\Program Files\Java\jre6\lib\deploy\jqs\ie\jqs_plugin.dll
O3 - Toolbar: XfireXO Toolbar - {5e5ab302-7f65-44cd-8211-c1d4caaccea3} - C:\Program Files\XfireXO\prxtbXfi2.dll
O3 - Toolbar: SHOUTcast Radio Toolbar - {0457331d-8ca6-4f97-9c26-6a9ef2b2dba8} - C:\Program Files\SHOUTcast Radio Toolbar\shoutcasttb.dll
O3 - Toolbar: Conduit Engine - {30F9B915-B755-4826-820B-08FBA6BD249D} - C:\Program Files\ConduitEngine\prxConduitEngine.dll
O3 - Toolbar: Ask Toolbar - {D4027C7F-154A-4066-A1AD-4243D8127440} - C:\Program Files\Ask.com\GenericAskToolbar.dll
O3 - Toolbar: Lexmark Toolbar - {1017A80C-6F09-4548-A84D-EDD6AC9525F0} - C:\Program Files\Lexmark Toolbar\toolband.dll
O3 - Toolbar: XFINITY Toolbar - {4b9bcce8-a70b-402a-a7e1-db96831ee26f} - C:\Program Files\xfin_portal\comcastdx.dll
O4 - HKLM\..\Run: [VolPanel] "C:\program files\Creative\Sound Blaster X-Fi\Volume Panel\VolPanlu.exe" /r
O4 - HKLM\..\Run: [CTxfiHlp] CTXFIHLP.EXE
O4 - HKLM\..\Run: [UpdReg] C:\WINDOWS\UpdReg.EXE
O4 - HKLM\..\Run: [SoundMAXPnP] C:\Program Files\Analog Devices\Core\smax4pnp.exe
O4 - HKLM\..\Run: [SoundMAX] "C:\program files\Analog Devices\SoundMAX\Smax4.exe" /tray
O4 - HKLM\..\Run: [Launch LgDeviceAgent] "C:\Program Files\Logitech\GamePanel Software\LgDevAgt.exe"
O4 - HKLM\..\Run: [Launch LCDMon] "C:\Program Files\Logitech\GamePanel Software\LCD Manager\LCDMon.exe"
O4 - HKLM\..\Run: [Launch LGDCore] "C:\Program Files\Logitech\GamePanel Software\G-series Software\LGDCore.exe" /SHOWHIDE
O4 - HKLM\..\Run: [Kernel and Hardware Abstraction Layer] KHALMNPR.EXE
O4 - HKLM\..\Run: [egui] "C:\Program Files\ESET\ESET Smart Security\egui.exe" /hide /waitservice
O4 - HKLM\..\Run: [EPSON Stylus C42 Series] C:\WINDOWS\System32\spool\DRIVERS\W32X86\3\E_S10IC1.EXE /P23 "EPSON Stylus C42 Series" /O6 "USB001" /M "Stylus C42"
O4 - HKLM\..\Run: [UnlockerAssistant] "C:\Program Files\Unlocker\UnlockerAssistant.exe" -H
O4 - HKLM\..\Run: [MaAgent] C:\Program Files\MarkAny\ContentSAFER\MaAgent.exe
O4 - HKLM\..\Run: [TkBellExe] "C:\Program Files\Common Files\Real\Update_OB\realsched.exe" -osboot
O4 - HKLM\..\Run: [AdobeCS4ServiceManager] "C:\Program Files\Common Files\Adobe\CS4ServiceManager\CS4ServiceManager.exe" -launchedbylogin
O4 - HKLM\..\Run: [googletalk] C:\Program Files\Google\Google Talk\googletalk.exe /autostart
O4 - HKLM\..\Run: [LogitechQuickCamRibbon] "C:\Program Files\Logitech\Logitech WebCam Software\LWS.exe" /hide
O4 - HKLM\..\Run: [Macro Manager] C:\Program Files\GrassSoft\MouseRecorder\MacroManager.exe /q
O4 - HKLM\..\Run: [NodEnabler] C:\Program Files\ESET\ESET Smart Security\NodEnabler\NodEnabler.exe /s
O4 - HKLM\..\Run: [GrooveMonitor] "C:\Program Files\Microsoft Office\Office12\GrooveMonitor.exe"
O4 - HKLM\..\Run: [WindowsLivePhone] C:\Program Files\Windows Live\Device Manager\msgrdvmn.exe /AutoRun
O4 - HKLM\..\Run: [QuickTime Task] "C:\Program Files\QuickTime\qttask.exe" -atboottime
O4 - HKLM\..\Run: [iTunesHelper] "C:\Program Files\iTunes\iTunesHelper.exe"
O4 - HKLM\..\Run: [Adobe Reader Speed Launcher] "C:\Program Files\Adobe\Reader 9.0\Reader\Reader_sl.exe"
O4 - HKLM\..\Run: [Adobe ARM] "C:\Program Files\Common Files\Adobe\ARM\1.0\AdobeARM.exe"
O4 - HKLM\..\Run: [ApnUpdater] "C:\Program Files\Ask.com\Updater\Updater.exe"
O4 - HKLM\..\Run: [lxeamon.exe] "C:\Program Files\Lexmark S300-S400 Series\lxeamon.exe"
O4 - HKLM\..\Run: [EzPrint] "C:\Program Files\Lexmark S300-S400 Series\ezprint.exe"
O4 - HKLM\..\Run: [SunJavaUpdateSched] "C:\Program Files\Common Files\Java\Java Update\jusched.exe"
O4 - HKLM\..\Run: [NvCplDaemon] RUNDLL32.EXE C:\WINDOWS\system32\NvCpl.dll,NvStartup
O4 - HKLM\..\Run: [NvMediaCenter] RunDLL32.exe NvMCTray.dll,NvTaskbarInit -login
O4 - HKLM\..\Run: [nwiz] C:\Program Files\NVIDIA Corporation\nview\nwiz.exe /installquiet
O4 - HKLM\..\Run: [Z-5 Speakers] C:\Program Files\Logitech\Z-5 Speakers\Z-5 Speakers.exe
O4 - HKCU\..\Run: [msnmsgr] "C:\Program Files\Windows Live\Messenger\msnmsgr.exe" /background
O4 - HKCU\..\Run: [Steam] "C:\program files\Steam\steam.exe" -silent
O4 - HKCU\..\Run: [MRDaemon.exe] C:\Program Files\Mnet\QuickManager2\MRDaemon.exe
O4 - HKCU\..\Run: [ctfmon.exe] C:\WINDOWS\system32\ctfmon.exe
O4 - HKCU\..\Run: [Google Update] "C:\Documents and Settings\Chaddie Dimiati\Local Settings\Application Data\Google\Update\GoogleUpdate.exe" /c
O4 - HKCU\..\Run: [NVIDIA nTune] "C:\Program Files\NVIDIA Corporation\nTune\nTuneCmd.exe" clear
O4 - HKCU\..\Run: [WindowsLivePhone] "C:\Program Files\Windows Live\Device Manager\msgrdvmn.exe" /AutoRun
O4 - HKCU\..\Run: [Pando Media Booster] C:\Program Files\Pando Networks\Media Booster\PMB.exe
O4 - HKCU\..\Run: [ComcastAntispyClient] "C:\Program Files\comcasttb\ComcastSpywareScan\ComcastAntispy.exe" /hide
O4 - Startup: LimeWire On Startup.lnk = C:\program files\LimeWire\LimeWire.exe
O4 - Startup: Xfire.lnk = C:\program files\Xfire\Xfire.exe
O4 - Global Startup: Logitech SetPoint.lnk = C:\program files\Logitech\SetPoint\SetPoint.exe
O4 - Global Startup: Update ESET's license.lnk = C:\program files\ESET\MiNODLogin\MiNODLogin.exe
O8 - Extra context menu item: &Download by Orbit - res://C:\Program Files\Orbitdownloader\orbitmxt.dll/201
O8 - Extra context menu item: &Grab video by Orbit - res://C:\Program Files\Orbitdownloader\orbitmxt.dll/204
O8 - Extra context menu item: &SHOUTcast Search - C:\Documents and Settings\All Users\Application Data\SHOUTcast Radio Toolbar\ieToolbar\resources\en-US\local\search.html
O8 - Extra context menu item: Do&wnload selected by Orbit - res://C:\Program Files\Orbitdownloader\orbitmxt.dll/203
O8 - Extra context menu item: Down&load all by Orbit - res://C:\Program Files\Orbitdownloader\orbitmxt.dll/202
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~3\Office12\EXCEL.EXE/3000
O9 - Extra button: (no name) - {09C04DA7-5B76-4EBC-BBEE-B25EAC5965F5} - C:\Program Files\Google\Google Gears\Internet Explorer\0.5.36.0\gears.dll
O9 - Extra 'Tools' menuitem: &Gears Settings - {09C04DA7-5B76-4EBC-BBEE-B25EAC5965F5} - C:\Program Files\Google\Google Gears\Internet Explorer\0.5.36.0\gears.dll
O9 - Extra button: Send to OneNote - {2670000A-7350-4f3c-8081-5663EE0C6C49} - C:\PROGRA~1\MICROS~3\Office12\ONBttnIE.dll
O9 - Extra 'Tools' menuitem: S&end to OneNote - {2670000A-7350-4f3c-8081-5663EE0C6C49} - C:\PROGRA~1\MICROS~3\Office12\ONBttnIE.dll
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - C:\PROGRA~1\MICROS~3\Office12\REFIEBAR.DLL
O9 - Extra button: (no name) - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra 'Tools' menuitem: @xpsp3res.dll,-20001 - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O16 - DPF: {6414512B-B978-451D-A0D8-FCFDF33E833C} (WUWebControl Class) -
O16 - DPF: {DFBBCB52-4D9F-4D0E-BF4A-A51223FC2541} (NSAppHelperWizrd Class) -
O18 - Protocol: grooveLocalGWS - {88FED34C-F0CA-4636-A375-3CB6248B04CD} - C:\Program Files\Microsoft Office\Office12\GrooveSystemServices.dll
O18 - Protocol: skype4com - {FFC8B962-9B40-4DFF-9458-1830C7DD7F5D} - C:\PROGRA~1\COMMON~1\Skype\SKYPE4~1.DLL
O22 - SharedTaskScheduler: Browseui preloader - {438755C2-A8BA-11D1-B96B-00A0C90312E1} - C:\WINDOWS\system32\browseui.dll
O22 - SharedTaskScheduler: Component Categories cache daemon - {8C7461EF-2B13-11d2-BE35-3078302C2030} - C:\WINDOWS\system32\browseui.dll
O23 - Service: Apple Mobile Device - Apple Inc. - C:\Program Files\Common Files\Apple\Mobile Device Support\AppleMobileDeviceService.exe
O23 - Service: Bonjour Service - Apple Inc. - C:\Program Files\Bonjour\mDNSResponder.exe
O23 - Service: Creative Audio Engine Licensing Service - Creative Labs - C:\Program Files\Common Files\Creative Labs Shared\Service\CTAELicensing.exe
O23 - Service: Creative Service for CDROM Access - Creative Technology Ltd - C:\WINDOWS\system32\CTsvcCDA.exe
O23 - Service: Creative Audio Service (CTAudSvcService) - Creative Technology Ltd - C:\program files\Creative\Shared Files\CTAudSvc.exe
O23 - Service: ESET HTTP Server (EhttpSrv) - ESET - C:\Program Files\ESET\ESET Smart Security\EHttpSrv.exe
O23 - Service: ESET Service (ekrn) - ESET - C:\Program Files\ESET\ESET Smart Security\ekrn.exe
O23 - Service: FLEXnet Licensing Service - Acresso Software Inc. - C:\Program Files\Common Files\Macrovision Shared\FLEXnet Publisher\FNPLicensingService.exe
O23 - Service: Google Update Service (gupdate) (gupdate) - Google Inc. - C:\Program Files\Google\Update\GoogleUpdate.exe
O23 - Service: Google Update Service (gupdatem) (gupdatem) - Google Inc. - C:\Program Files\Google\Update\GoogleUpdate.exe
O23 - Service: iPod Service - Apple Inc. - C:\Program Files\iPod\bin\iPodService.exe
O23 - Service: iWinTrusted - iWin Inc. - C:\Program Files\iWin Games\iWinTrusted.exe
O23 - Service: Java Quick Starter (JavaQuickStarterService) - Sun Microsystems, Inc. - C:\Program Files\Java\jre6\bin\jqs.exe
O23 - Service: Logitech Bluetooth Service (LBTServ) - Logitech, Inc. - C:\program files\common files\Logishrd\Bluetooth\LBTServ.exe
O23 - Service: Process Monitor (LVPrcSrv) - Logitech Inc. - C:\Program Files\Common Files\LogiShrd\LVMVFM\LVPrcSrv.exe
O23 - Service: lxeaCATSCustConnectService - Lexmark International, Inc. - C:\WINDOWS\System32\spool\DRIVERS\W32X86\3\\lxeaserv.exe
O23 - Service: lxea_device - - C:\WINDOWS\system32\lxeacoms.exe
O23 - Service: Macro Expert - Unknown owner - c:\program files\grasssoft\mouserecorder\MacroService.exe
O23 - Service: nProtect GameGuard Service (npggsvc) - Unknown owner - C:\WINDOWS\system32\GameMon.des.exe (file missing)
O23 - Service: nTune Service (nTuneService) - NVIDIA - C:\Program Files\NVIDIA Corporation\nTune\nTuneService.exe
O23 - Service: NVIDIA Driver Helper Service (NVSvc) - NVIDIA Corporation - C:\WINDOWS\system32\nvsvc32.exe
O23 - Service: NVIDIA Update Service Daemon (nvUpdatusService) - NVIDIA Corporation - C:\Program Files\NVIDIA Corporation\NVIDIA Updatus\daemonu.exe
O23 - Service: PnkBstrA - Unknown owner - C:\WINDOWS\system32\PnkBstrA.exe
End of file - 17044 bytes
Last Edit: December 13, 2011, 10:17:40 am by Hoov
Malware Removal Mentors
Global Moderator
Diamond Member
Posts: 24151
Unwilling part owner of Gov't. Motors and Chrysler
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #1 on:
December 13, 2011, 10:20:48 am »
Hello, welcome to SpywareHammer.
I go by Hoov, and I will be helping you with your problem. I must ask you to do a few things for me.
First, tell me everything that you have done, if anything, to try and fix this problem.Also tell me any other problems you are having, no matter how small or long you have been dealing with them.
Second, please only use 1 forum to help clear up your problem. Posting on more than 1 and following instructions from more than 1 forum will cause those helping you to pull out thier hair.
Third, follow my instructions - If you can't for some reason, or if you don't understand something, please tell me. If you deviate from my instructions, tell me, it may make a difference on where we go.
Fourth, Have faith. I will do all I can to get your computer working, and if I can't - someone else here will know something else to try.
Fifth, if we start this fix, I need you to stick with me until the end. Just because your computer is running better does not mean it is fixed.
Before we start trying to fix your computer, you need to make sure your data is backed up. Also let me know of any software you have running that encrypts your harddrive.
One last thing, I need you to tell me if this computer belongs to a school or to a company or orginization of some kind. If it does, please let me know. Also tell me if there is an IT department responsible for this computer.
Now onto trying to fix your computer.
Please download
by Grinler and save it to your desktop.
Link 2
Link 3
Link 4
Double-click on the Rkill desktop icon to run the tool.
If using Vista, right-click on it and
Run As Administrator
black DOS box
will briefly flash and then disappear. This is normal and indicates the tool ran successfully.
If not, delete the file, then download and use the one provided in
Link 2
A log pops up at the end of the run. This log file is located at C:\rkill.log. Please post this only if requested to by the person helping you. Otherwise you can close this log when you wish.
If it does not work, repeat the process and attempt to use one of the remaining links until the tool runs.
If the tool does not run from any of the links provided, please let me know.
Please download
Malwarebytes Anti-Malware
and save it to your desktop.
alternate download link 1
alternate download link 2
MBAM may "make changes to your registry" as part of its disinfection routine. If using other security programs that detect registry changes (ie Spybot's Teatimer), they may interfere or alert you. Temporarily
disable such programs
or permit them to
the changes.
Make sure you are connected to the Internet.
Double-click on
to install the application.
When the installation begins, follow the prompts and do not make any changes to default settings.
When installation has finished, make sure you leave both of these checked:
Update Malwarebytes' Anti-Malware
Launch Malwarebytes' Anti-Malware
Then click
MBAM will automatically start and you will be asked to update the program before performing a scan.
If an update is found, the program will automatically update itself. Press the
button to close that box and continue.
If you encounter any problems while downloading the definition updates, manually download them from
and just double-click on mbam-rules.exe to install.
On the Scanner tab:
Make sure the "
Perform Quick Scan
" option is selected.
Then click on the
If asked to select the drives to scan, leave
all the drives
selected and click on the
Start Scan
The scan will begin and "
Scan in progress
" will show at the top. It may take some time to complete so please be patient.
When the scan is finished, a message box will say "
The scan completed successfully. Click 'Show Results' to display all objects found
to close the message box and continue with the removal process.
Back at the main Scanner screen:
Click on the
Show Results
button to see a list of any malware that was found.
Make sure that
everything is checked
, and click
Remove Selected
When removal is completed, a log report will open in Notepad.
The log is automatically saved and can be viewed by clicking the
tab in MBAM.
Copy and paste the contents of that report in your next reply. Be sure to post the complete log to include the top portion which shows MBAM's database version and your operating system.
Exit MBAM when done.
: If MBAM encounters a file that is difficult to remove, you will be asked to reboot your computer so MBAM can proceed with the disinfection process. If asked to restart the computer, please do so immediately.
Failure to reboot normally
(not into safe mode) will prevent MBAM from removing all the malware.
If you have to reboot the computer because Malwarebytes' Anti-Malware asked you to, then please run RKILL again and then proceed.
Please read carefully and follow these steps.
and save it to your Desktop.
Extract its contents to your desktop.
Once extracted, open the TDSSKiller folder and doubleclick on
to run the application, then on
Start Scan.
If an infected file is detected, the default action will be
, click on
If a suspicious file is detected, the default action will be
, click on
It may ask you to reboot the computer to complete the process. Click on
Reboot Now
If no reboot is require, click on
. A log file should appear. Please copy and paste the contents of that file here.
If a reboot is required, the report can also be found in your root directory, (usually C:\ folder) in the form of "
". Please copy and paste the contents of that file here.
Consumer Security
If I am helping you and you don't hear from me for 24Hrs, send me a PM Please!
Bronze Member
Posts: 7
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #2 on:
December 13, 2011, 10:51:09 am »
Heya Hoov, I really appreciate all the help I'll be receiving from you!
Specifically for the trojan that comes up, I haven't done anything besides scan with NOD32 and CCleaner. CCleaner didn't find anything like it, but NOD32 just cannot get rid of it. I haven't tried anything else besides that.
No software running that encrypts the harddrive, and the computer belongs to me only, it's a personal home computer.
As requested, here are the logs!
RKILL: This log file is located at C:\rkill.log.
Please post this only if requested to by the person helping you.
Otherwise you can close this log when you wish.
Rkill was run on 12/13/2011 at 11:35:38.
Operating System: Microsoft Windows XP
Processes terminated by Rkill or while it was running:
Rkill completed on 12/13/2011 at 11:35:43.
Malwarebytes: Malwarebytes' Anti-Malware 220.127.116.110
Database version: 8365
Windows 5.1.2600 Service Pack 3
Internet Explorer 8.0.6001.18702
mbam-log-2011-12-13 (11-47-53).txt
Scan type: Quick scan
Objects scanned: 207722
Time elapsed: 9 minute(s), 20 second(s)
Memory Processes Infected: 0
Memory Modules Infected: 0
Registry Keys Infected: 0
Registry Values Infected: 0
Registry Data Items Infected: 0
Folders Infected: 0
Files Infected: 2
Memory Processes Infected:
(No malicious items detected)
Memory Modules Infected:
(No malicious items detected)
Registry Keys Infected:
(No malicious items detected)
Registry Values Infected:
(No malicious items detected)
Registry Data Items Infected:
(No malicious items detected)
Folders Infected:
(No malicious items detected)
Files Infected:
c:\RECYCLER\s-1-5-21-796845957-2077806209-682003330-1003\Dc53\bdl188.8.131.52.exe (Riskware.KG) -> Quarantined and deleted successfully.
c:\WINDOWS\ss_2ne1_toanyone.scr (Trojan.Downloader) -> Quarantined and deleted successfully.
TDSSKiller: Still processing (had to reboot)
Bronze Member
Posts: 7
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #3 on:
December 13, 2011, 11:16:13 am »
Test message is a testz.
For some reason I keep getting the forbidden message...and it's not letting me post the TDSSKiller log :(.
Malware Removal Mentors
Global Moderator
Diamond Member
Posts: 24151
Unwilling part owner of Gov't. Motors and Chrysler
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #4 on:
December 13, 2011, 11:25:31 am »
There is something in the log that is triggering the forum firewall. Please zip up the log and attach it to a reply.
Consumer Security
If I am helping you and you don't hear from me for 24Hrs, send me a PM Please!
Bronze Member
Posts: 7
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #5 on:
December 13, 2011, 12:08:28 pm »
Oh gotcha! Here ya go
Malware Removal Mentors
Global Moderator
Diamond Member
Posts: 24151
Unwilling part owner of Gov't. Motors and Chrysler
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #6 on:
December 13, 2011, 12:18:02 pm »
When you restarted your computer, did you get the same message from NOD32?
Consumer Security
If I am helping you and you don't hear from me for 24Hrs, send me a PM Please!
Bronze Member
Posts: 7
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #7 on:
December 13, 2011, 01:49:38 pm »
Nope, nothing came up from NOD32. I'm scanning now to see if it'll come up through that.
Malware Removal Mentors
Global Moderator
Diamond Member
Posts: 24151
Unwilling part owner of Gov't. Motors and Chrysler
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #8 on:
December 13, 2011, 04:39:50 pm »
Let me know how it goes. If all is well, and you have no more problems, we can do some cleanup and call it good.
Consumer Security
If I am helping you and you don't hear from me for 24Hrs, send me a PM Please!
Bronze Member
Posts: 7
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #9 on:
December 13, 2011, 05:58:55 pm »
It looks like it detected nothing, which is spectacular! If you have any tips on cleaning up my system, please do share haha. I know it's a bit messy, and I'd love to have it running more smoothly!
Oh and any idea what would be causing the frequent network timeouts?
Malware Removal Mentors
Global Moderator
Diamond Member
Posts: 24151
Unwilling part owner of Gov't. Motors and Chrysler
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #10 on:
December 13, 2011, 06:13:34 pm »
Forgot about that.
Download and scan with
When you get to the website, there is a dark grey box on the left side with two tabs along the top. Inside this Dark Grey box is a light grey box. Below that light grey box is where the download links are at. The pay amount is for paid support.
2. Before first use,
select Options > Advanced and UNCHECK
Only delete files in Windows Temp folder older than 48 hours
3. Then select the items you wish to clean up.
In the Windows Tab
Clean all entries in the "Internet Explorer" section except Cookies if you want to keep those.
Clean all the entries in the "Windows Explorer" section.
Clean all entries in the "System" section.
Clean all entries in the "Advanced" section.
Clean any others that you choose.
In the Applications Tab
Clean all except cookies in the Firefox/Mozilla section if you use it.
Clean all in the Opera section if you use it.
Clean Sun Java in the Internet Section.
Clean any others that you choose.
4. Click the "
Run Cleaner
" button.
5. A pop up box will appear advising this process will permanently delete files from your system.
6. Click "
" and it will scan and clean your system.
7. Click "
" when done.
Click Start. click run, type: cmd, and press Enter
Type: netsh winsock reset, and then press the ENTER key.
Type: Exit and press ENTER.
Restart the computer.
Test out your browser and see if the network keeps timing out. If it does time out then follow the procedure below.
Open a command prompt (all programs > Accessories > Command Prompt) and type in
Ipconfig /all > ipconfig.txt and then hit enter. Then type in ipconfig.txt to open notepad with the log. Copy it and paste it in to your next response.
Consumer Security
If I am helping you and you don't hear from me for 24Hrs, send me a PM Please!
Bronze Member
Posts: 7
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #11 on:
December 14, 2011, 01:09:13 pm »
It seems that cleaning the trojan off yesterday completely fixed it! Since then, I have been browsing with no timeouts, so it seems both birds were knocked out with one stone :).
I just need to clean this machine up!
Malware Removal Mentors
Global Moderator
Diamond Member
Posts: 24151
Unwilling part owner of Gov't. Motors and Chrysler
Re: [In Progress] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out
Reply #12 on:
December 14, 2011, 01:17:21 pm »
Now there are a few thing's you need to do to fully clean your system and keep it secure.
Run OTC
to your desktop and run it
Click Yes to beginning the Cleanup process and remove these components, including this application.
You will be asked to reboot the machine to finish the Cleanup process. Choose Yes.
Cleaning out Temporary Files etc.
There are several different products that you can use for this. You can go thru the Internet Options in the windows Control Panel. There are several programs that also do the job better than windows does it, in my opinion. There is
System Security Suite
. Also sometimes other program sometimes do it as well as what you originally got it for like ZoneAlarm Security Suite. Just make sure to keep them updated and use them regularly.
Disable and Enable System Restore
I recommend you turn off System restore, and then turn it back on so that you will not be able to restore your problems to a clean computer.
For Vista use these instructions,
Windows Vista Restore Guide
For XP use these instructions,
Windows XP System Restore Guide
Re-enable system restore with instructions from tutorial above
Create a System Restore Point
Go to all programs, then to accessories, then to system tools, then to system restore. Check the box for create restore point (not select a restore point), then click next and follow the instructions.
Make your Internet Explorer more secure
- This can be done by following these simple instructions: (unless you are using ZoneAlarm Security Suite or something similar, then you would secure the browser thru the firewall). There are some good basic instructions for that
Use a different browser other than IE
(most exploits are pointed towards IE). One of them is
It is also worth trying
for controlling spam in your e-mail.
Always use an UPDATED anti-virus program
Make sure you update this at least weekly, if not more often. This is one thing that may save you more than anything else.
Run malware scanners
. Three free ones are
Spybot Search and Destroy
, and
Malwarebytes' Anti-Malware
Always use a firewall
Any firewall is better than none, and you should pick a firewall that you will use, as even the best firewall is worthless if you turn it off.
Learn how to use your firewall
Only programs that need it should have access to the net. But these are specific to the firewall you use, so you will need to learn how. Several firewalls have support forums here. My page will help you with ZoneAlarm if that is what you choose.
Never run two Antivirus programs or two Firewalls at the same time.
They can interfere with each other and cause problems. Some people swear that more protection is provided, but the reverse is true. They tend to argue amongst themselves and end up leaving holes. Now I have more than 1 AV installed on my computer, and I keep them up to date. I only run one at a time, but each program has weakness's, so I keep a backup in case my computer starts acting up.
: Windows and IE, and whatever other software that you have that connects to the net, needs to be kept updated. The reason is, these programs connect to the net, and if there is an internal security problem, you have already told your firewall to allow the communication, and thus you will have allowed a hole. UPDATES are important. I suggest that you make sure that Windows Updates and the updates for your antivirus and antimalware programs are set for automatic updates. I also suggest running
Secunia PSI
. It will monitor the software you have installed and let you know when something needs to be updated.
Don't ever use P2P or filesharing software
Even the safest P2P file sharing programs that do not contain bundled spyware, still expose you to risks because of the very nature of the P2P file sharing process. By default, most P2P file sharing programs are configured to automatically launch at startup. They are also configured to allow other P2P users on the same network open access to a shared directory on your computer. The reason for this is simple. File sharing relies on its members giving and gaining unfettered access to computers across the P2P network. However, this practice can make you vulnerable to data and identity theft. Even if you change those risky default settings to a safer configuration, the act of downloading files from an anonymous source greatly increases your exposure to infection. That is because the files you are downloading may actually contain a disguised threat. Many very malicious worms and trojans, such as the Storm Worm, target and spread across P2P files sharing networks because of their known vulnerabilities.
Before using any malware detection / removal software
Check with
Rogue/Suspect Spyware List
That way you will know if the program you are looking at is on the up and up. If you want to know how it stacks up against other programs check out
We have a good guide here at
Spyware Hammer
on how to prevent Malware in the Future. You might want to peruse this and follow the recommendations in there.
Let us know if you have any more problems, either new or old.
Have a good time surfing the net, but stay safe.
If you have no more problems, let me know and I will mark this as resolved. Or if you have more questions, ask away, that is why I am here.
Consumer Security
If I am helping you and you don't hear from me for 24Hrs, send me a PM Please!
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[Resolved] Win32/Agent.SDG.Gen trojan & connection keeps randomly timing out