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Broaden your selection: Category/Software-development
shell (30)
- BASH Debugger
- BASH Debugger provides a patched BASH that enables better debugging support as well as improved error reporting. It also contains the most comprehensive source code debugger for BASH that has been written. It can be used as a springboard for other experimental features (such as adding hashtables), since development is maintained openly and developers are encouraged to participate.
- Biabam Is A Bash Attachment Mailer. In other words, BIABAM lets users send email attachments from the command line. It is similar to using Mutt to send attachments on the command line, but without the overhead of a complete email client.
- Backup Shell
- 'bksh' is a simple program designed to be a shell for SSH. It copies its input to a given backup file. Its goal is to allow administrators to create backup-only accounts. It works for either tape only or file & tape backups, and works as a shell so clients have very limited server access.
- Bash
- Bash is an sh-compatible shell that incorporates useful features from the Korn shell (ksh) and C shell (csh). It is intended to conform to the IEEE POSIX P1003.2/ISO 9945.2 Shell and Tools standard. It offers functional improvements over sh for both programming and interactive use; these include command line editing, unlimited size command history, job control, shell functions and aliases, indexed arrays of unlimited size, and integer arithmetic in any base from two to sixty-four. Bash can run most sh scripts without modification.
- Bash.Diff
- Bash.Diff is a patch against Bash that incorporates many features from Awk, Python, Zsh, Ksh, and others. In the main core, it adds the following: new brace expansion {a..b}; new parameter expansion ${var ...}; new command substitution $(=...); string concatenation (+=); extended for, while, and until loops; extended case statement; and new try-block with integer exception. As builtin commands, it adds the following: sscanf(3) wrapper; extensive array and regex(3) operations; GDBM, SQLite, PostgreSQL, and MySQL database interfaces; and an HTML template engine (BASP).
- BashDiff
- Bash.Diff is a patch against Bash shell. In the main core, it adds the following syntax: {a..b}; ${var ...}; then-else-fi to for/while/until/case statements; try-block with string exception. As builtins, it provides adds the following: sscanf(3), ctype.h wrappers; array, regex(3), stack, queue operations; GDBM, SQLite, PostgreSQL, MySQL database interfaces; HTML template engine (BASP); Expat XML parser interface; x-y char plot; DOS, CSV, Awk support; Libwebserver interface; RPN calculator with <math.h> functions; and, GTK+2 interface for GUI dialog.
- Bosh
- bosh takes the output of the specified command and displays it using a simple ncurses interface. Actions can be configured and run using the currently selected line of the output as part of the action. An example is to use ps as the main command and kill as an action. Then, using bosh, the ps output can be browsed to find a particular process, which is then killed.
- Diradm
- 'diradm' is a script for managing POSIX users and groups stored in a LDAP directory, offering the same features as the traditional passwd file utilities useradd/usermod/userdel and groupadd/groupmod/groupdel. It uses the ldapsearch, ldapadd, ldapmodify, and ldapdelete utilities from the OpenLDAP project to perform the needed queries against the LDAP database.
- Dish
- The 'diligence' shell (dish) lets you execute commands on several hosts. By using expect to automate interactive remote logins via ssh, rsh or telnet, dish executes commands, sequentially or simultaneously, on all specified hosts. It is a powerful system administration tool for a group (cluster) of heterogeneous hosts allowing remote control from a single point of management. 'dish' is very flexible, and has similar functionality to IBM's dsh (distributed shell) as well as the ability to remotely execute commands which require authentication - ie in case of password change, scp inside ssh, password-protected smbfs mount, su shell, etc.
- Distribulator
- 'Distribulator' is an SSH-based command execution and file transfer utility that includes support for batch, console, and shell integration modes, multiple server environments, and auditing via syslog.
… further results
Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.3 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the page "GNU Free Documentation License".
The copyright and license notices on this page only apply to the text on this page. Any software described in this text has its own copyright notice and license, which can usually be found in the distribution itself.


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Registerjr and Drewsicle3210 take on the Anabolic Algorithm Stack byMAN SPORTS (Sponsored Dual Log)
12 weeks of muscle ripping BULK FEST with PR-XT andNolvadren XT!!
Thanks @neddo and MAN Sports for allowing my brother and I the opportunity to do this.
I have never done a true bulk. This is going to be epic, atleast for me anyways. I have completed my cut with P90X and lifting, and withsome outstanding supps by numerous companies. I have taken NXT solo and Inoticed some big changes in just 1 month. Now its time to take it to the nextlevel with this game changing stack. Time to dump the thermogenics and startfeeding these muscles.
The Supps-
MAN Sports PR-XT- 6/6/6/6/6/6/6/6/0/0/0/0
MAN Sports NXT -0/0/0/0/2/2/2/2/2/2/2/2
MAN Sports GAMEDAY pre-workout (starting week 3 after a 2week stim break)
Fish Oil
PROTEIN!!! At least 1gm per pound of body weight
FOOD!!! Trying to keep it clan most days of the week. Calories will be around 3000-3300 a day.
The Workout Plan-
Registerjr has devised out plan, changes weekly.
The Foundation-
Starting weight- 177
Starting Bench Max- ? Never did this, Jefit calculates 216,but well get the right number this week.
Starting Deadlift Max- 326
Starting Squat Max-202.67 (hip surgeries done Sep and Dec2012, so this is my ultimate weak area)
Starting Overhead Press Max- ? Well get it
Starting Pics-
I haven't decided if I am going to post my MACROS/Calories. I may, but with my job it is hard to have the time.
I am discontinuing Intermittent fasting for this bulk due to the fact that it would be difficult for me to get all of my calories in during an 8 hour feeding window.

subset: commoncrawl


text:
FDI inflow to Bahrain surges to $891mInflow of foreign direct investment (FDI) into Bahrain soared to $891 million last year, 14 per cent higher than $781m in 2011, Bahrain Chamber of Commerce and Industry (BCCI) president Dr Essam Fakhro said yesterday. Dr Fakhro sa More… |
GCC FDI increases to reach $26bnForeign direct investment (FDI) in the GCC in 2012 increased slightly over the previous year to reach $26.4 billion. This brings to an end three consecutive years of declining FDI flows to the region since the pre-financial crisis More… |
FDI in Tunisia falls 1.3pc in H1Foreign direct investment in Tunisia fell by 1.3 percent in the first half of 2013, official data showed on Saturday, a likely reflection of political strife in the north African state. Foreign investments fell More… |
FDI inflow to GCC steady at $26 billionForeign direct investment (FDI) to GCC countries remained steady in 2012 at $26 billion despite a strong decline registered in Saudi Arabia, because of significant FDI growth in all other countries in the group, a report said. FDI More… |
Sri Lanka to ease foreign ownership restrictionsSri Lanka will allow foreigners full ownership of businesses if they invest more than $10 million, a minister said, and the measure will likely be introduced within two months. The proposed change comes as the $59 billion economy More… |
Lower Mena corporate tax 'will draw more FDI'Lowering of corporate tax rates by Mena governments will increase the flow of foreign direct investment (FDI) into the region, according to experts. However, as a consequence of lower tax collec More… |
Non-oil sector to play key role in Saudi GDPSaudi Arabia's GDP is likely to grow three per cent in real terms driven by a vigorous non-oil sector which will compensate for the decline in oil output in 2013, a report said. Growth in the non-oil sector will remain above More… |
Bahrain's growth 'to top 5pc in 2012'Bahrain's economy is in good health with growth expected to exceed 5 per cent this year, said a top government official. Growth is estimated to have reached 3.9 per cent last year, added Economic Development Board (EDB) acting More… |
Qatar Airways 'may buy stake in India's SpiceJet'India's low-cost carrier (LCC) SpiceJet is in talks with some foreign airlines to sell a stake in the company and Qatar Airways is the most likely investor, said a report. A deal could mater More… |
Abu Dhabi to host top Moroccan property expoAbu Dhabi will host next month a leading global Moroccan real estate and lifestyle event, making its first appearance in the Middle East having already established a strong presence in Europe for the last 16 years. SMAP Expo Abu D More… |


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Tue, 23 Oct 2012 VMWare Fusion 5.0 review
Impressive upgrade brings 'near native' performance to Windows apps running on your Mac.
- Manufacturer: VMware
- Pros: Good performance for routine computing tasks with Windows software, cheaper than Parallels Desktop
- Cons: Gaming performance could still be improved
- Min specs: Any 64-bit capable Intel Mac (Compatible with Core 2 Duo, Xeon, i3, i5, i7 processors or better) Minimum 2GB of RAM (4GB or more recommended) 750MB free disk space for VMware Fusion and at least 5GB for each virtual machine Mac OS X 10.6.7 or later; OS X Lion or OS X Mountain Lion recommended Operating system installation media (disk or disk image) for virtual machines. Microsoft Windows is not included with VMware Fusion. Recommended graphics hardware for Windows Aero support: NVIDIA 8600M or better ATI 2600 or better
- Price: Standard Edition - £39.99; Professional Edition - £68.69
- Star rating:
Fusion isn't quite as popular with Mac users as Parallels Desktop, perhaps because VMWare tends to focus more on the corporate and enterprise markets where Macs are still relatively rare.
That corporate emphasis is immediately noticeable with this upgrade as you now have the choice of buying either the standard Fusion 5 for £40 or Fusion 5 Professional for £68.69. The Professional edition also offers discounts on multi-user licenses for larger businesses and educational organizations.
Don't let that corporate emphasis put you off, though, as the standard non-corporate edition of Fusion 5 is still a really good choice for ordinary home users and small businesses too. In fact, VMWare has gone out of its way to help non-technical users to get started with Fusion 5 by including a series of video tutorials that cover options such as installing Windows and running Windows programs directly on the Mac desktop. And while Fusion 5 may lack the more polished interface of Parallels Desktop, it compensates by being quite a bit cheaper at just £39.99.
As with Parallels Desktop 8, many of the new features in Fusion 5 are simply designed to bring it up to date with Mountain Lion. You can use the new Search feature in Launchpad to quickly locate and launch individual Windows programs, while support for AirPlay allows you to view your Windows virtual machine running on an HDTV via the AppleTV – something that could come in handy for running presentations on a large screen.
You can receive status updates for your virtual machines via the Notification Centre in Mountain Lion, and there are high-res graphics updates for the new MacBook Pro with Retina Display. Fusion has also been updated to work with Windows 8, both within a self-contained virtual machine and when running from a Boot Camp partition on your Mac.
The program's interface has been tidied up too. The Library window still allows you to view icons of all your virtual machines, but also includes a new list view that has been designed for the smaller screens on laptop Macs. Your virtual machines are listed in a panel on the left-hand side of the Library window, while the rest of the window displays a larger preview of the selected virtual machine.
If you have multiple virtual machines on your Mac the list view also allows you to keep things tidy by organizing them into folders, and Fusion now allows you to allocate 8GB of memory to each virtual machine, up to a total of 60GB when running multiple virtual machines.
We tested the performance of a Windows 7 virtual machine running the PCMark benchtesting software, which tests general tasks such as web browsing or running business software. Fusion 5 produced an impressive score of 3000 – handily beating the 2200 scored by Parallels Desktop 8, and rivaling a number of i5-based PC laptops that we've seen recently. It's not just hype when VMWare claims that Fusion 5 can run Windows software at 'near native' speeds.
The one exception to that claim, however, is when running 3D games and graphics. Parallels Desktop 8 comes out on top here, consistently producing frame rates that are 15-20% higher than Fusion 5 when running Windows games such as Skyrim and Far Cry 2. However, neither program is quite ready to replace Boot Camp as the best way of running Windows games on your Mac, so that's probably not a deal-breaker for many people.
1 |


text:
Embellished Muscle
Born out of the angst of the LA punk rock scene, Chaser was molded by the evolution of the music scene. Utilizing soft blends, Chaser tees are luxuriously soft and their designs continue to evolve with the ever changing music scene.
- 100% cotton
- Sequin, bead and embroidered embellishments throughout
- Raw cut arm holes and hem
- Asymmetric hem
- Styled with One Teaspoon Trashwhores in Maverick.
- Styled with gorjana Kaia Ring in Gold.
- Styled with gorjana Teagan Ring in Gold.
- Styled with Dream Collective Diamond River Cuff in Black.
- Styled with gorjana Delaney Square Ring in Gold.
- Styled with gorjana Arrow Cuff in Gold.
- Modeled in size S. See fit guide for model's dimensions.
- Revolve Style No. CSER-WS154
- Manufacturer Style No. CW5557


text:
Q&A: Beating the Winter Blues
Q&A: Beating the Winter Blues
I've got a bad case of the winter blues. Any ideas for perking me up?
Feeling down and out during the wintertime is quite common. The shorter days and long, dark nights have a profound effect on many of us and, for some, trigger a serious case of winter blues.
If you are looking for a natural way to lift your mood, make a conscious effort to bathe yourself in light. Try your best to spend at least an hour outdoors in the sun every day. While indoors, remember to look out the window every so often. And if you aren't blessed with sunny weather, consider investing in full-spectrum lighting or a light box, both of which contain all the wavelengths of natural light (all the colors of the rainbow).
In one of the earliest studies on the therapeutic use of full-spectrum light, researchers treated patients who needed a mood boost by lengthening their "days." For an hour before dawn and an hour after dusk, the subjects sat in front of a full-spectrum light box.
For most, the response was miraculous: The winter blues evaporated in a matter of days and were held at bay as long as subjects received the extra light. If they were away from their light boxes for a few days, lo and behold, those bummed-out feelings returned.
New research also suggests that "light deficiency" can be a problem for some people throughout the year and the mood-boosting effects of light therapy aren't limited to the cold, dark winter months. Spending time in front of a light-box or using full-spectrum lighting in your home can positively influence all areas of your health and well-being year-round.
One easy way to reap the benefits of light therapy is to purchase a two- or four-tube light fixture fitted with full-spectrum fluorescent bulbs. Mount it on the wall or prop it up at eye level and simply sit near it a couple of times a day.
Another option is to replace some of the bulbs in the light fixtures in your home and office with full-spectrum bulbs, creating a full-spectrum room of your own. You don't have to replace every fixture, but the majority of lighting in the rooms where you spend the most time should be full-spectrum in order to get the proper effect.
A light box is another alternative that combines full-spectrum bulbs in a smaller, more portable package. Verilux is one reputable company that offers several full-spectrum lighting options. Ott-Lite also sells full-spectrum lamps, bulbs, and tubes.
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text: An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate Gigliobianco, Tiziana ; GANGOLF, Marjorie ; Lakaye, Bernard et al in Scientific Reports (2013), 3(1071), In E. coli, thiamine triphosphate (ThTP), a putative signaling molecule, transiently accumulates in response to amino acid starvation. This accumulation requires the presence of an energy substrate ... [more ▼] In E. coli, thiamine triphosphate (ThTP), a putative signaling molecule, transiently accumulates in response to amino acid starvation. This accumulation requires the presence of an energy substrate yielding pyruvate. Here we show that in intact bacteria ThTP is synthesized from free thiamine diphosphate (ThDP) and Pi, the reaction being energized by the proton-motive force (Dp) generated by the respiratory chain. ThTP production is suppressed in strains carrying mutations in F1 or a deletion of the atp operon. Transformation with a plasmid encoding the whole atp operon fully restored ThTP production, highlighting the requirement for FoF1-ATP synthase in ThTP synthesis. Our results show that, under specific conditions of nutritional downshift, FoF1-ATP synthase catalyzes the synthesis of ThTP, rather than ATP, through a highly regulated process requiring pyruvate oxidation. Moreover, this chemiosmotic mechanism for ThTP production is conserved from E. coli to mammalian brain mitochondria. [less ▲] Detailed reference viewed: 26 (10 ULg)Structural Determinants of Specificity and Catalytic Mechanism in mammalian 25-kDa Thiamine Triphosphatase ; Kerff, Frédéric ; et al in Biochimica et Biophysica Acta - General Subjects (2013), 1830 Background: Thiamine triphosphate (ThTP) is present in most organisms and might be involved in intracellular signaling. In mammalian cells, the cytosolic ThTP level is controlled by a specific thiamine ... [more ▼] Background: Thiamine triphosphate (ThTP) is present in most organisms and might be involved in intracellular signaling. In mammalian cells, the cytosolic ThTP level is controlled by a specific thiamine triphosphatase (ThTPase), belonging to the CYTH superfamily of proteins. CYTH proteins are present in all superkingdoms of life and act on various triphosphorylated substrates. Methods: Using crystallography, mass spectrometry and mutational analysis, we identified the key structural determinants of the high specificity and catalytic efficiency of mammalian ThTPase. Results: Triphosphate binding requires three conserved arginines while the catalytic mechanism relies on an unusual lysine-tyrosine dyad. By docking of the ThTP molecule in the active site, we found that Trp-53 should interact with the thiazole part of the substrate molecule, thus playing a key role in substrate recognition and specificity. Sea anemone and zebrafish CYTH proteins, which retain the corresponding Trp residue, are also specific ThTPases. Surprisingly, the whole chromosome region containing the ThTPase gene is lost in birds. Conclusion: The specificity for ThTP is linked to a stacking interaction between the thiazole heterocycle of thiamine and a tryptophan residue. The latter likely plays a key role in the secondary acquisition of ThTPase activity in early metazoan CYTH enzymes, in the lineage leading from cnidarians to mammals. General significance: We show that ThTPase activity is not restricted to mammals as previously thought but is an acquisition of early metazoans. This, and the identification of critically important residues, allows us to draw an evolutionary perspective of the CYTH family of proteins. [less ▲] Detailed reference viewed: 52 (20 ULg)High inorganic triphosphatase activities in bacteria and mammalian cells: Identification of the enzymes involved. Kohn, Grégory ; Delvaux, David ; Lakaye, Bernard et al in PLoS ONE (2012), 7(9), 43879 Background: We recently characterized a specific inorganic triphosphatase (PPPase) from Nitrosomonas europaea. This enzyme belongs to the CYTH superfamily of proteins. Many bacterial members of this ... [more ▼] Background: We recently characterized a specific inorganic triphosphatase (PPPase) from Nitrosomonas europaea. This enzyme belongs to the CYTH superfamily of proteins. Many bacterial members of this family are annotated as predicted adenylate cyclases, because one of the founding members is CyaB adenylate cyclase from A. hydrophila. The aim of the present study is to determine whether other members of the CYTH protein family also have a PPPase activity, if there are PPPase activities in animal tissues and what enzymes are responsible for these activities. Methodology/Principal Findings: Recombinant enzymes were expressed and purified as GST- or His-tagged fusion proteins and the enzyme activities were determined by measuring the release of inorganic phosphate. We show that the hitherto uncharacterized E. coli CYTH protein ygiF is a specific PPPase, but it contributes only marginally to the total PPPase activity in this organism, where the main enzyme responsible for hydrolysis of inorganic triphosphate (PPPi) is inorganic pyrophosphatase. We further show that CyaB hydrolyzes PPPi but this activity is low compared to its adenylate cyclase activity. Finally we demonstrate a high PPPase activity in mammalian and quail tissue, particularly in the brain. We show that this activity is mainly due to Prune, an exopolyphosphatase overexpressed in metastatic tumors where it promotes cell motility. Conclusions and General Significance: We show for the first time that PPPase activities are widespread in bacteria and animals. We identified the enzymes responsible for these activities but we were unable to detect significant amounts of PPPi in E. coli or brain extracts using ion chromatography and capillary electrophoresis. The role of these enzymes may be to hydrolyze PPPi, which could be cytotoxic because of its high affinity for Ca2+, thereby interfering with Ca2+ signaling. [less ▲] Detailed reference viewed: 35 (7 ULg)Mutations of EFHC1, linked to juvenile myoclonic epilepsy, disrupt radial and tangential migrations during brain development de Nijs, Laurence ; Wolkoff, Nathalie ; Coumans, Bernard et al in Human Molecular Genetics (2012), 21(23), 5106-17 Detailed reference viewed: 6 (3 ULg)The role of melanin-concentrating hormone in conditioned reward learning ; ; et al in European Journal of Neuroscience (2012), 36 Detailed reference viewed: 14 (2 ULg)Myoclonin1/EFHC1 in cell division, neuroblast migration, synapse/dendrite formation in juvenile myoclonic epilepsy Grisar, Thierry ; Lakaye, Bernard ; de Nijs, Laurence et al in Noebels, JL; Avoli, M; Rogawski, MA (Eds.) et al Jasper's Basic Mechanisms of the Epilepsies, 4th edition (2012) Detailed reference viewed: 34 (1 ULg)Molecular evolution of the CYTH superfamily of proteins Bettendorff, Lucien ; Delvaux, David ; Kohn, Grégory et al in FEBS Journal (2012), 279(Suppl. s1), 438 Molecular evolution of the CYTH superfamily of proteins L. Bettendorff, D. Delvaux, G. Kohn, P. Wins, B. Lakaye GIGA-Neurosciences, University of Liège, Belgium The CYTH superfamily of proteins was named ... [more ▼] Molecular evolution of the CYTH superfamily of proteins L. Bettendorff, D. Delvaux, G. Kohn, P. Wins, B. Lakaye GIGA-Neurosciences, University of Liège, Belgium The CYTH superfamily of proteins was named after the two founding members, the CYaB adenylyl cyclase from Aeromonas hydrophila and the human 25-kDa THiamine triphosphatase (ThTPase). Members of this superfamily of proteins exist in all organisms including bacteria, archaea, plants and animals (except in birds) and can be traced back to the Last Universal Common Ancestor. They are characterized by a consensus sequence including several charged residues involved in divalent cation and triphosphate binding. Indeed, all members of the CYTH family that are characterized act on triphosphate derivatives and require at least one divalent cation for catalysis. The Nitrosomonas europaea (1) and E.coli CYTH proteins are specific inorganic triphosphatases. We propose that inorganic triphosphate (PPPi), the most simple triphosphate compound that can be imagined, is the primitive substrate of CYTH proteins. Other enzyme activities such as adenylate cyclase (in A. hydrophila), mRNA triphosphatase (in fungi and protozoans) and ThTPase (in metazoans) activities are secondary acquisitions. We show that ThTPase activity is not limited to mammals, but Sea anemone and Zebrafish CYTH proteins are already specific ThTPases and the acquisition of this enzyme activity is linked to the presence of a Trp (W53 in mammalian ThTPases) residue involved in the binding of the thiazole heterocycle of the thiamine molecule. The importance of W53 for the specificity of mammalian ThTPases is confirmed by site-directed mutagenesis. Furthermore, we propose a conserved catalytic mechanism between inorganic triphosphatases and ThTPases, based on a catalytic dyad comprising a Lys and a Tyr residue, explaining the alkaline pH optimum of CYTH proteins. (1) Delvaux et al. J. Biol. Chem 286 (2011) 34023-35 [less ▲] Detailed reference viewed: 35 (4 ULg)A specific inorganic triphosphatase from Nitrosomonas europaea: structure and catalytic mechanism Delvaux, David ; ; Gabelica, Valérie et al in Journal of Biological Chemistry (2011), 286 The CYTH superfamily of proteins is named after its two founding members, the CyaB adenylyl cyclase from Aeromonas hydrophila and the human 25-kDa thiamine triphosphatase. Because these proteins often ... [more ▼] The CYTH superfamily of proteins is named after its two founding members, the CyaB adenylyl cyclase from Aeromonas hydrophila and the human 25-kDa thiamine triphosphatase. Because these proteins often form a closed β-barrel, they are also referred to as "Triphosphate Tunnel Metalloenzymes" (TTM). Functionally, they are characterized by their ability to bind triphosphorylated substrates and divalent metal ions. These proteins exist in most organisms and catalyze different reactions, depending on their origin. Here we investigate structural and catalytic properties of the recombinant TTM protein from Nitrosomonas europaea (NeuTTM), a 19-kDa protein. Crystallographic data show that it crystallizes as a dimer and that, in contrast to other TTM proteins, it has an open β-barrel structure. We demonstrate that NeuTTM is a highly specific inorganic triphosphatase, hydrolyzing tripolyphosphate (PPPi) with high catalytic efficiency in the presence of Mg2+. These data are supported by native mass spectrometry analysis showing that the enzyme binds PPPi (and Mg-PPPi) with high affinity (Kd < 1.5 μM), while it has a low affinity for ATP or thiamine triphosphate. In contrast to Aeromonas and Yersinia CyaB proteins, NeuTTM has no adenylyl cyclase activity, but it shares several properties with other enzymes of the CYTH superfamily, e.g. heat-stability, alkaline pH optimum and inhibition by Ca2+ and Zn2+ ions. We suggest a catalytic mechanism involving a catalytic dyad formed by K52 and Y28. The present data provide the first characterization of a new type of phosphohydrolase (unrelated to pyrophosphatases or exopolyphosphatases), able to hydrolyze inorganic triphosphate with high specificity. [less ▲] Detailed reference viewed: 71 (25 ULg)Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells Gangolf, Marjorie ; ; Radermecker, Marc et al in PLoS ONE (2010), 5(10), 13616 Background Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine ... [more ▼] Background Thiamine (vitamin B1) is an essential molecule for all life forms because thiamine diphosphate (ThDP) is an indispensable cofactor for oxidative energy metabolism. The less abundant thiamine monophosphate (ThMP), thiamine triphosphate (ThTP) and adenosine thiamine triphosphate (AThTP), present in many organisms, may have still unidentified physiological functions. Diseases linked to thiamine deficiency (polyneuritis, Wernicke-Korsakoff syndrome) remain frequent among alcohol abusers and other risk populations. This is the first comprehensive study on the distribution of thiamine derivatives in human biopsies, body fluids and cell lines. Methodology and Principal Findings Thiamine derivatives were determined by HPLC. In human tissues, the total thiamine content is lower than in other animal species. ThDP is the major thiamine compound and tissue levels decrease at high age. In semen, ThDP content correlates with the concentration of spermatozoa but not with their motility. The proportion of ThTP is higher in humans than in rodents, probably because of a lower 25-kDa ThTPase activity. The expression and activity of this enzyme seems to correlate with the degree of cell differentiation. ThTP was present in nearly all brain and muscle samples and in ~60% of other tissue samples, in particular fetal tissue and cultured cells. A low ([ThTP]+[ThMP])/([Thiamine]+[ThMP]) ratio was found in cardiovascular tissues of patients with cardiac insufficiency. AThTP was detected only sporadically in adult tissues but was found more consistently in fetal tissues and cell lines. Conclusions and Significance The high sensitivity of humans to thiamine deficiency is probably linked to low circulating thiamine concentrations and low ThDP tissue contents. ThTP levels are relatively high in many human tissues, as a result of low expression of the 25-kDa ThTPase. Another novel finding is the presence of ThTP and AThTP in poorly differentiated fast-growing cells, suggesting a hitherto unsuspected link between these compounds and cell division or differentiation. [less ▲] Detailed reference viewed: 52 (22 ULg)Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress Gigliobianco, Tiziana ; Lakaye, Bernard ; et al in BMC Microbiology (2010), 10 Detailed reference viewed: 30 (17 ULg)Major impairments of glutamatergic transmission and long term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1 ; Adamantidis, Antoine ; et al in Journal of Neurophysiology (2010), 104 Detailed reference viewed: 26 (9 ULg)Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression ; ; et al in BMC Developmental Biology (2010), 10 Detailed reference viewed: 10 (1 ULg)Distribution of EFHC1 or myoclonin 1 in mouse neural structures Leon, Christine ; de Nijs, Laurence ; et al in Epilepsy Research (2010), 88 Detailed reference viewed: 8 (4 ULg)Ethanol-induced behaviors in mice genetically deficient in MCH1 receptors Didone, Vincent ; Tirelli, Ezio ; Quertemont, Etienne et al in Alcoholism, Clinical & Experimental Research (2010), 34(8), 93-93 Detailed reference viewed: 20 (1 ULg)Effects of the H(3) receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions. Brabant, Christian ; Alleva, Livia ; Grisar, Thierry et al in Psychopharmacology (2009), 202(4), 673-87 RATIONALE: Previous studies have shown that intraperitoneal injections of thioperamide, an imidazole-based H(3) receptor inverse agonist that enhances histamine release in the brain, potentiate cocaine ... [more ▼] RATIONALE: Previous studies have shown that intraperitoneal injections of thioperamide, an imidazole-based H(3) receptor inverse agonist that enhances histamine release in the brain, potentiate cocaine-induced hyperlocomotion. The present study examined the involvement of the histaminergic system in these effects of thioperamide in mice. MATERIALS AND METHODS: We investigated whether immepip, a selective H(3) agonist, could reverse the potentiating effects of thioperamide. Moreover, the non-imidazole H(3) inverse agonist A-331440 was tested on the locomotor effects of cocaine. Using high-performance liquid chromatography with ultraviolet detection, cocaine plasma concentrations were measured to study potential drug-drug interactions between thioperamide and cocaine. Finally, thioperamide was tested on the locomotor effects of cocaine in histamine-deficient knockout mice in order to determine the contribution of histamine to the modulating effects of thioperamide. RESULTS: Thioperamide potentiated cocaine-induced hyperlocomotion in normal mice, and to a higher extent, in histamine-deficient knockout mice. A-331440 only slightly affected the locomotor effects of cocaine. Immepip did not alter cocaine-induced hyperactivity but significantly reduced the potentiating actions of thioperamide on cocaine's effects. Finally, plasma cocaine concentrations were more elevated in mice treated with thioperamide than in mice that received cocaine alone. CONCLUSIONS: The present results indicate that histamine released by thioperamide through the blockade of H(3) autoreceptors is not involved in the ability of this compound to potentiate cocaine induced-hyperactivity. Our data suggest that thioperamide, at least at 10 mg/kg, increases cocaine-induced locomotion through the combination of pharmacokinetic effects and the blockade of H(3) receptors located on non-histaminergic neurons. [less ▲] Detailed reference viewed: 70 (12 ULg)Cytoskeletal genes and idiopathic epilepsies Lakaye, Bernard ; de Nijs, Laurence ; et al in Schwartzkroin, A. (Ed.) Encyclopedia of Basic Epilepsy Research (2009) Detailed reference viewed: 4 (1 ULg)Melanin-concentrating hormone and immune function Lakaye, Bernard ; Coumans, Bernard ; Harray, Sophie et al in Peptides (2009), 30 To date,melanin-concentrating hormone (MCH) has been generally considered as peptide acting almost exclusively in the central nervous system. In the present paper, we revise the experimental evidence ... [more ▼] To date,melanin-concentrating hormone (MCH) has been generally considered as peptide acting almost exclusively in the central nervous system. In the present paper, we revise the experimental evidence, demonstrating that MCH and its receptors are expressed by cells of the immune system and directly influence the response of these cells in some circumstances. This therefore supports the idea that, as with other peptides, MCH could be considered as a modulator of the immune system. Moreover, we suggest that this could have important implications in several immune-mediated disorders and affirm that there is a clear need for further investigation [less ▲] Detailed reference viewed: 28 (7 ULg)EFHC1 interacts with microtubules to regulate cell division and cortical development de Nijs, Laurence ; Leon, Christine ; Nguyen, Laurent et al in Nature Neuroscience (2009), 12(10), 1266-74 Mutations in the EFHC1 gene are linked to juvenile myoclonic epilepsy (JME), one of the most frequent forms of idiopathic generalized epilepsies. JME is associated with subtle alterations of cortical and ... [more ▼] Mutations in the EFHC1 gene are linked to juvenile myoclonic epilepsy (JME), one of the most frequent forms of idiopathic generalized epilepsies. JME is associated with subtle alterations of cortical and subcortical architecture, but the underlying pathological mechanism remains unknown. We found that EFHC1 is a microtubule-associated protein involved in the regulation of cell division. In vitro, EFHC1 loss of function disrupted mitotic spindle organization, impaired M phase progression, induced microtubule bundling and increased apoptosis. EFHC1 impairment in the rat developing neocortex by ex vivo and in utero electroporation caused a marked disruption of radial migration. We found that this effect was a result of cortical progenitors failing to exit the cell cycle and defects in the radial glia scaffold organization and in the locomotion of postmitotic neurons. Therefore, we propose that EFHC1 is a regulator of cell division and neuronal migration during cortical development and that disruption of its functions leads to JME [less ▲] Detailed reference viewed: 83 (26 ULg)Deletion of Melanin-Concentrating Hormone Receptor-1 gene accentuates D-amphetamine-induced psychomotor activation but neither the subsequent development of sensitization nor the expression of conditioned activity in mice Tyhon, Amélie ; Lakaye, Bernard ; Grisar, Thierry et al in Pharmacology, Biochemistry & Behavior (2008), 88 The present study aimed to test the hypothesis that mice lacking the MCHR1 receptor (Melanin-Concentrating Hormone Receptor-1) present an elevated vulnerability towards the neurobehavioural effects of D ... [more ▼] The present study aimed to test the hypothesis that mice lacking the MCHR1 receptor (Melanin-Concentrating Hormone Receptor-1) present an elevated vulnerability towards the neurobehavioural effects of D-amphetamine, presumably due to previously established up-regulations of dopamine D1 receptors in these mice. We examined the psychomotor effects of five once-daily injections of 1.5 and 3 mg/kg D-amphetamine (i.p.) or ten once-daily injections of 2.25 mg/kg D-amphetamine in knockout (KO) mice lacking the MCHR1 receptor. The first injection of Damphetamine induced a greater psychomotor response amongst the KO mice at 2.25 and 3.0 mg/kg. On all subsequent D-amphetamine injections, KO mice still showed greater levels of psychomotor activity than the WT mice, but with no between-genotype difference in the rate of development of sensitization (similar slopes of the curves). Furthermore, 24 h after the last injection of 2.25 mg/kg D-amphetamine both genotypes exhibited a significant post-sensitization conditioned activity. Thus, MCHR1 receptors are likely not deeply involved in the mechanisms of induction of sensitization and related conditioned activity induced by D-amphetamine, albeit our results confirm a contribution of these receptors to the mechanisms of the acute effects of that drug, possibly via an inhibitory action on the dopaminergic mesolimbic system. Our results do not support the hypothesis of a functional contribution of MCHR1 receptors to the addictive effects of D-amphetamine [less ▲] Detailed reference viewed: 16 (3 ULg)Amphetamine- and cocaine-induced conditioned place preference and concomitant psychomotor sensitization in mice with genetically inactivated melanin-concentrating hormone MCH(1) receptor. Tyhon, Amélie ; Lakaye, Bernard ; Adamantidis, Antoine et al in European Journal of Pharmacology (2008), 599(1-3), 72-80 The melanin-concentrating hormone MCH(1) receptor has been proposed to exert an inhibitory control on monoaminergic (especially dopaminergic) activity within the mesolimbic system, which underpins drug ... [more ▼] The melanin-concentrating hormone MCH(1) receptor has been proposed to exert an inhibitory control on monoaminergic (especially dopaminergic) activity within the mesolimbic system, which underpins drug seeking and reward. That hypothesis predicts that an inactivation of these receptors should enhance the sensitivity to drug rewarding effects. To test that prediction, we examined the propensity of mice lacking the melanin-concentrating receptor (MCH(1) KO) and their intact counterparts (WT) to form cocaine- and amphetamine-induced conditioned place preference. The conditioned rewarding effects induced by 0.375, 0.75, 1.5 and 3 mg/kg amphetamine were assessed in two sub-experiments and those induced by 1, 2, 4 and 8 mg/kg cocaine in two other sub-experiments. All mice were tested under saline for place preference 24 h following four every-other-day conditioning trials and an initial pre-conditioning session under saline. Most of the cocaine and amphetamine doses induced place preference, but without any genotype difference being revealed. Also, none of the cocaine doses induced psychomotor sensitization during conditioning, whereas amphetamine generated clear-cut dose-dependent sensitization in both genotypes. Albeit MCH(1) KO mice exhibited higher levels of psychomotor activation, the rates of sensitization were comparable across genotypes at 1.5 and 3 mg/kg amphetamine. Moreover, 0.375 and especially 0.75 mg/kg amphetamine produced a slight but yet significant sensitization in MCH(1) KO but not in their WT counterparts. Despite such an effect, the results cannot be considered as unambiguously supportive of the tested prediction. [less ▲] Detailed reference viewed: 57 (2 ULg) |


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oh snap, our house was on sweet home style. forgot it was submitted. somewhere inside there is a bulldog going crazy.
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This is what I love about winter.
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daydreaming of this right now in brooklyn (via xenabitesback, sweethomestyle)
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i want to live where it snows.
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How charming is my best friend John's family home in Connecticut? textbook:(via sweethomestyle)
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How charming is my best friend John's family home in Connecticut?
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dollhouse or some insanely beautiful diorama!
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Email your comments to the Chancellor
Revised February 4, 2009
The ECU community, our friends and constituencies, and interested parties throughout the state are surely aware of the global financial crisis and the stress it has put on the entire state of North Carolina. This financial situation is impossible to predict with certainty, but most estimates are that it will be with us for at least another two years, that it will continue to be severe, and that it will have negative consequences throughout higher education.
I want our community to understand how we are affected and how we are responding. ECU, like all universities in the University of North Carolina system, is responding to a 6 percent "reversion" or deduction of appropriated funds for this fiscal year. This means that out of $260 million of state funding, we will not receive $15.5 million this year. About $3 million will be from our medical programs and about $12.5 million from the east campus. There is no guarantee that 6% is the ceiling; we are prepared for 7-8% one-time cuts.
We are meeting this cutback by delaying hirings or canceling searches, reducing costs in every way possible, conserving our resources, putting off purchases, and consolidating services. What we will not do is sacrifice our priorities. So, for example, we are actively building the dental school under the great leadership of Dr. Jim Hupp, and we will fund and expect strong services from the Pirate Tutoring Center which helps so many of our beginning students.
All ECU employees, students, and friends should realize that the real danger is base budget cuts throughout the next biennium (July 2009 through June 2011). We are preparing plans for base cuts between 3 percent and 7 percent for fiscal year 2009-2010. A 7 percent cut would mean that we would have to reduce staff and programs and services by $20 million. If the economy dictates further cuts in fiscal year 2010-11, every aspect of the university would be affected.
Under such a worst-case scenario, we have identified responses that include: consolidation of many support services into centralized and more efficient operations, outsourcing, loss of numerous administrative positions, freezes on travel and many other normal activities, postponed hiring, furloughs, and even reductions in force. Economic conditions dictate that we must be prepared for any eventuality, all the while hoping that North Carolina's strong regional economy shields us from the educational destruction that is already occurring in some states.
So much for the harsh reality. During these tough times, let's not lose track of the progress we have made and our great future. Our primary goal should be to emerge from the economic downturn with our priorities intact and to maintain our commitments to our state and region.
The way to do this is to maintain the priorities in our strategic plan and to focus on our community. We are all in this together and we will respond as one university. Here are five specific commitments that our administration is making:
We all recognize that times are tough. We will do our part and we will be better for it. Tomorrow starts here.


text:
TY for posting a real clip. I was half expecting some rick roll video. Damn, that really was a tease. The video looks like it has potential.
fuck, cant wait to hear this shit. looks and sounds like it has potential.
Yeah, I was wondering if that skit was gonna lead to a song or not, the beat sounded really cool. now I'm glad to know that it will. Can't wait to hear the full song
Willie Murk said:
Fuck yeah I knew that last skit on EBAH would lead to a song! It's even got the same beat. Should be dope as hellllll!
URALYA! Looks likes its gona be a sickass video! but now i know what hes trying to say, "your a liar"..haha just got it
Godfuckingdammit!!! This is torture! Ugh, I wanna hear the rest! Lol.
this teaser gives me of a RED NOSE type feel....no?
For some reason it reminds me of a mix between the videos for Like Yeah and Who Do I Catch
EVLNSTX said:
this teaser gives me of a RED NOSE type feel....no?
Tech N9ne 'Therapy' Available Now!
Prozak 'We All Fall Down' Available Now!
Krizz Kaliko 'Son of Sam' Now Available!
Stevie Stone '2 Birds 1 Stone' In Stores Now!
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¡MAYDAY! "Believers" In Stores Now
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Rittz "The Life And Times Of Jonny Valiant" Purchase Now!
CES Cru "Constant Energy Struggles" Purchase Now!
Kutt Calhoun "Black Gold" Album Now Available!
Brotha Lynch Hung "Mannibalector" Album In Stores Now!
Tech N9ne's Hostile Takeover: The Story Behind The Tour
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Tech N9ne – 'E.B.A.H.'/'Boiling Point' Combo EP Now In Stores!
Tech N9ne "Boiling Point" EP Now Available!
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Kutt Calhoun "Kelvin" EP Now Available!
Ces Cru "13" EP Now Available!
¡MAYDAY! "Thrift Store Halos" EP Now Available!
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text: What would you do with $19,000? Me? A new car...help pay for student loans…. Well...how's $19k for shoelaces made of 24-carat gold settle in your stomache? Colin Hart created the world's first-ever 24-carat gold laces using "ancient, artisan jewelry techniques". Each set is handmade by Colombian workers and takes 120 hours to produce. Colin has already sold a pair to "someone in the rap industry." He says: "Shoelaces are so boring and my gut is that people who have a love of the 'practical made special' will buy them." Of course, you can also opt for a cheaper version and get silver laces that will just run you $3,000. No big deal. On that note, I'm headin over to the store, buying some laces and spray paint.. and BOOM. Fashion, that.


text:
If the DREAM Act kids tug at Brewer's heart, then she ought to quit denying them a driver's license
by Dee Dee Garcia Blase on Jan. 30, 2013, under Legal Immigration Reform, Mexican-American / Chicano political activismThe Arizona Governor Jan Brewer has been viewed as our type of "Alabama Governor George Wallace" of the 21st century since she signed the draconian SB 1070 anti-immigrant law without a wavering hand.
It seems she is getting no love from the Mexican-American community in Arizona (see below), and more than likely her legacy will be to the tune of being the SB 1070 governor by many Mexican-Americans in the southwest.
Now she is changing her populist tune and claims the DREAM Act kids tug at her heart, however, Immigration Lawyer and Leader via Jose Penalosa thinks actions speak louder than words. If you are wondering and confused with regard to the change in the immigration tune coming from the GOP, Senator John McCain puts it simply when he said: "…that elections have consequences…" [Yet, to my knowledge the RNC still has not reversed their anti-immigrant platform.]
Jose Penalosa states:
I really want to believe that the Dream Act kids tug at her heart! Given that she came out on 8/15/12, the day DACA commenced, to deny driver's licenses to Dreamers really convinces me that her heart is hardened. If her heart is so touched by the Dreamers, you, Governor Brewer, should give the Dreamers a great Valentines Day gift and allow them to have licenses.
So we will truly see if the DREAM Act kids will tug at Brewer's heart. Let's see if she will stop denying these brilliant students and kids a driver's license by Valentine's Day 2013. Aver que pasa con eso.


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ALBANY, GA -- Live Oak Elementary School held a special luncheon Thursday where the "Live Oak Leaders" got to have lunch with local leaders.
In the program various public figures from the Albany area ate with students and discussed the meaning of leadership. Participants included Dougherty County Schools Superintendent Dr. Joshua Murfree, Albany Fire Department Chief James Carswell, Fox 31's Anchor Romney Smith and Chief Meteorologist Mike Morrison, along with others.
After lunch, guests were treated to a guided tour of the school by students. Participants say the luncheon was a great opportunity to interact with motivated young people and the students say they enjoyed the opportunity to learn from one on one conversations over lunch.
The "Live Oak Leaders" program is comprised of 52 students from 3rd, 4th, and 5th grade.
Related Links


text:
The man who could do it all!
Ian Terence Botham, arguably England's most
famous cricketer and one of the great all-rounders the game has seen, was born
on 24 November 1955 in Heswall, Cheshire. While a controversial player both on
and off the field at times, Botham also held a number of Test cricket records,
and still holds the record for the highest number of wickets taken by an
England bowler (383).
He has 14 Test centuries to his name; and also took
145 wickets and scored 2113 runs in ODIs.
In March 1980, Botham played for
Scunthorpe United, where he played as a centre half and made 11 appearances in
the Football League.
Botham was part of the trio of Sir Viv Richards and Joel
Garner, who were central to Somerset's golden age in the early 1980s. Botham,
who is now a TV commentator with Sky, was knighted in 2007.
One of the main
highlights of his Test career was the 1981 Ashes Tour, which was known as
Botham's Ashes for his stellar show.
He is also a conscientious fundraiser for
charitable causes, undertaking long-distance charity walks and doing untold
work for leukemia research.
- live match IND 124/5 (25.5 Overs)vs. INDSA1st ODI
- live match AUS 273/5 (91 Overs)vs. ENGAUS2nd Test
- live match WI 168/2 (49 Overs)vs. WINZ1st Test
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Wolfman | Posted on Feb 24 2013, 12:28 AM | ||||
For sure...good thing I'm too old to get into the kind of crap I used to get into, I'd be locked up for sure in todays politically correct times. |
Wolfman | Posted on Feb 24 2013, 12:25 AM | ||||
For sure Dude, todays world is just boring. Well, gotta go have a smoke. |
JuanitaC | Posted on Feb 23 2013, 08:18 PM | ||||
Hahahaha...when I remember all the trash we have done and almost died from laughing about it after... Let`s stop, boys, or they will lock us up! |
Mikedadski | Posted on Feb 23 2013, 06:29 PM | ||||
You got that right! It's somewhat ridiculous the state of affairs today. I'm grateful I'm not growing up in today's world. |
Wolfman | Posted on Feb 23 2013, 05:34 PM | ||||
No need to be sorry hun. It's nice to be able to talk to other members here. It is rather dumb these days with all the politically correct bullcrap going on. I was saying to a buddy just recently that the kids these days must find things pretty boring. You can't do anything anymore without getting in trouble or being judged. Hell, it's a miracle I'm still alive with the crap we used to do...and get away with. Certainly looks pretty boring these days. Music sucks too! Hell, here in Canada musically all we hear about is that little dork Bieber. It's pathetic. |
JuanitaC | Posted on Feb 23 2013, 04:24 PM | ||||
All this criminalizing smokers is really annoying nowadays. Also, here in Finland one goes buyng a bottle of wine while watching around that no neighbour or co- worker sees it....and anyway on friday evening eberybody is drunk....and hiding in a corner smoking. That is just sick. Our gouvernement just doesn`t get it, that the more they forbid things, the more people do it. Ok, this is far out of topic, sorry guys |
Mikedadski | Posted on Feb 23 2013, 01:20 AM | ||||
Or like the old Dean Martin show! A drink and a smoke! | |||||
Wolfman | Posted on Feb 22 2013, 10:30 AM | ||||
True about the political correctness. Kinda brought a smile to my face when I read about Dirk firing up a smoke. With the anti-smoking police out there it's a miracle the book wasn't called back to eliminate all traces of smoking before being put back on the shelf. I can still remember the days I used to watch Johnny Carson and he'd be sitting there live and fire one up. The good ol days for sure. |
Mikedadski | Posted on Feb 22 2013, 12:59 AM | ||||
Forgot about that!! The earlier books didn't have the political correctness garbage in them either. Working on Night Probe now. Love it. |
Wolfman | Posted on Feb 21 2013, 11:45 AM | ||||
Yes, I admit Mike, there certainly were places in the story Al would have fit in nicely. A good read none the less though. Forgot to add that you can tell this book was one of his early ones as Dirk smokes cigarettes in this one. |
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text:
To open presents to.
We're awl pawthetic and kweepy and can't get giwrls. That's why we fight wobots. lib-er-ty /ˈlɪbərti/ [lib-er-tee] noun, plural -ties. 1. freedom from arbitrary or despotic government or control.
Local 597 Service Fitter Metal Trade Journeyman PAY ME NOW OR PAY ME LATER It was working when I left... Liberalism-Ideas so good they mandate them
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Mom and pop shops say yes, Record Store Day co-founder says no. What do you think?
.....Why don't they just call it Amoeba Store Day
guitarded wrote:Seems like it puts asses in the aisles at my local shops...
Don't see how anyone is getting screwed by that.
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Hang tight!
Recipe by LUPE KEMP
"Pumpkin pie cake with butter and walnut topping."
Watch video tips and tricks
1 (15 ounce) can canned pumpkin puree
1 (12 fluid ounce) can evaporated milk
4 eggs
1 cup white sugar
1 teaspoon ground cinnamon
1/2 teaspoon ground nutmeg
1/2 teaspoon ground allspice
1/2 teaspoon salt
1 (18.25 ounce) package yellow cake mix
2 cups chopped walnuts
7/8 cup margarine, softened
Delicious, as always. I've made this several times. Usually with Yellow cake mix, but i've used White and Vanilla and it's been about the same each time--always a hit! I usually don't invert it, but it's great either way. And definitely even better with a dollop of whipping cream. Also, i mix about 3/4 cup of the cake mix into the pumpkin mixture--I think it gets rid of that mushy texture the pumpkin otherwise tends to have. I made half with pecans (was out of walnuts) and half with no nuts. Everyone agreed it was much better with the nuts. I used 4 tsp of Pumpkin Pie seasoning, and it wasn't too much...could have even used more. and i only used 6 tbsp of butter-it was plenty.
I used brown sugar instead of white and pecans because it is what I had on hand. I baked it for 15 minutes longer than called for and it turned out wonderfully.
25 Ratings
I made this recipe exactly as stated. The flavor was delicious but the cake was somewhat wet and mushy. What am I doing wrong?
Super easy to make! Delicious, but I think mine needed to bake longer being that's it was a little squishy at the bottom.
Wow, I just made this for a potluck and sneeked a bite out of the corner. Wonderful. I did not use 7/8 cup of margarine as the recipe called for but only used 7/8 stick (7 Tbs) of margarine. It worked out great. Thanks.
This is the BEST holiday cake ever!! I doubled the ingredients and baked it in a huge roaster-sized pan, and it turned out beautifully! I took it to our large Christmas gathering of family & friends, and everyone raved and demanded some to leave with. Simply divine and so easy. This is my new "traditional" dessert for the holidays from now on!
Yum! Outstanding dessert and I loved the use of the walnuts. I wouldn't changed anything about this dessert at all. The baking time was right on for me.
Very good... I used pecans instead of walnuts which worked great.
* Percent Daily Values are based on a 2,000 calorie diet.
Pumpkin Walnut Cake
Serving Size: 1/18 of a recipe Servings Per Recipe: 18 Amount Per Serving Calories: 386 Calories from Fat: 214
Get the season's best recipes for holiday feasting.
Holiday cookies, cakes, pies, and breads. Get recipes and inspiration.
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See how to make a sweetly spicy 5-star pumpkin roll cake.
See how to make a moist and creamy coconut cake.
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Decorative Pocket Lock 6", Privacy
Deltana Pocket Locks are a reliable choice for all sliding doors. They are offered in an array fine finishes.
Additional Deltana Links
- View Manufacturer Warranty
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Our SKU: Deltana SDL60
This product is listed under the following manufacturer number(s):
- Deltana SDL60U5
Antique Brass - Deltana SDL60U15
Brushed Nickel - Deltana SDL60U10B
Oil Rubbed Bronze - Deltana SDL60U3
Polished Brass - Deltana SDL60U26
Polished Chrome - Deltana SDL60U14
Polished Nickel - Deltana SDL60US15
Satin Nickel
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Runners from all 50 states and more than 30 countries travel to Sacramento each December to experience the California International Marathon. Whether you're traveling nationally, internationally, or driving in from a surrounding Northern California area, we encourage you to book your airfare and hotel rooms well in advance of marathon weekend. Be sure to take advantage of special offers and rates from official marathon hotel and travel partners.
Here you will find information on local hotels, area attractions, and transportation tips.


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Local News
2220 results total, viewing 2061 - 2070
OMER — The Arenac County Historical Society (ACHS) is hosting its third annual Christmas at Ye Olde Courthouse in Omer during the first two weekends in December.
ACHS Member Joann Gulau says …
By John Fischer
Staff writer | 12/1/08 | 213 views |
ARENAC COUNTY — Roger Burgess, Kevin O'Neill, April Stokr and Leo Nashatka, four defendants in a prostitution scandal involving underage females in Turner, all appeared in the 23rd Circuit Court …
The sounds of the season will come alive when the Arenac Choraleers perform three concerts titled "When Christmas Comes…"
The first show is Dec. 6 at the Tawas United Methodist Church, …
260 views
STANDISH — The "flu" season has begun and with more and more people spreading the bug, you need to know how to protect yourself.
According to St. Mary's of Michigan Standish Hospital …
By John Fischer
Staff writer | 12/1/08 | 207 views |
23RD CIRCUIT — A write-in candidate has never unseated an incumbent judge in the state of Michigan, but Tawas Attorney Christopher Martin, whose issues with the Michigan Secretary of State and …
By Tim Barnum
Staff writer | 12/2/08 | 200 views |
ARENAC COUNTY — Despite a three-percent reduction in funds from last year, the Arenac County Road Commission is prepared for the winter forthcoming.
According to Arenac County Road Commission …
By John Fischer
Staff writer | 11/26/08 | 172 views |
"You said it" is a new online reader-opinion driven forum, where you can speak up and let your voice be heard on a given topic. This week's topic is local shopping. Please answer the following …
STANDISH TOWNSHIP — If you thought the $378,543 distributed by the Saginaw-Chippewa Indian Tribe during its first round of two-percent class three gaming revenue sharing in May was significant, you …
By Tim Barnum
Staff writer | 11/25/08 | 272 views |
ARENAC COUNTY — A negotiation on Tuesday, Nov. 18 between Arenac County and its local Steelworkers' Union did little to change an implemented labor contract that has been highly criticized by …
By Tim Barnum
Staff writer | 11/25/08 | 222 views |
ARENAC COUNTY — Discussion at a Nov. 18 Board of Commissioners Committee of a Whole meeting regarding a proposed rental code for the county didn't go over well with seven landlords in attendance …
By Tim Barnum
Staff writer | 11/21/08 | 193 views |


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North East Angling News and Info for the week ending January 20th. Reports compiled from The Journal.
News & Info for the Region (click on the links):
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Given the state of the Guitar Hero games, and the decline in their popularity, should Neversoft give up the GH banner and make songs for the RBN.
We could get some of the decent Neversoft bands like Endless Sporadic.
I don't think it is extremely likely, but I would love to see it happen.
It could be sort of the way that Nintendo and Sega used to compete and Sega failed at consoles so they started just making games for Nintendo and other consoles.
I think it is a great idea.


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Friday, December 13, 2013 As one of the largest museums in the United States, the Philadelphia Museum of Art invites visitors from around the world to explore its renowned collections, acclaimed special exhibitions, and enriching programs, both in person and online.
Léger: Modern Art and the Metropolis
Join exhibition curator Anna Vallye on a tour through the colorful galleries of Léger: Modern Art and the Metropolis. See how Léger and his contemporaries were inspired by the energy and movement of the modern city to combine different arts into their own work. A sculpture expresses motion like a film, paintings become like advertising posters, and color combines with architecture to form murals, all working together to create a new vision of urban space brought to life.
Watch Video >> Also On ViewNow Through December 18, 2013 All Dressed Up: Fashions for Children and Their Families focuses on clothing from the late
eighteenth through mid-twentieth centuries, comparing and contrasting adults' apparel with
children's smaller styles.New In the GalleriesGallery 232, second floor Discover paintings and sculpture created for the Sakya lineage, one of the four main traditions of Tibetan Buddhism. Founded more than a thousand years ago in southern Tibet, the Sakya lineage held tremendous political power in the region during the thirteenth century. The Lamdre (literally "the path and the fruit") is the principal teaching of this lineage. What's NewToday at the MuseumCollection ToursEverything Eakins Starts at 10:15 a.m.Park House Programs Holiday Trolley Tour - Laurel Hill, Strawberry Mansion, Woodford 10:30 a.m. - 12:30 p.m. Stay Informed Subscribe To Podcasts
Receive RSS Feeds Museum e-Newsletters Follow Us On Twitter Connect On Facebook tumblr |


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This map is scaled for use with our Deadlands Noir 28mm miniatures, and can be printed with or without grid lines.
For printed and packaged, dry-erase versions, see the Pinnacle website.
* "Humanoid" figure flats (normal, small and large size) are presented in tri-fold format at about 25mm scale (each flat is about 1.25" tall, with eye-level for a normal humanoid at about 1" tall).<>... [click here for more]


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"Internet Purchases Only" "Not a Retail Store Stock Item"
This item is viewable at our retail store in LEXINGTON, KY. It may be on display and is available for immediate purchase and pick-up.
click here to see all brands we sell
*Please Note!! Many of our pictures are stock photos provided to us by the manufacturer and do not necessarily represent the actual item being purchased. Please verify this picture accurately reflects the product described by the title and description on this page before you place your order.
Shoot More and More Often. Blazer handgun ammo is everything you may need. Whether it be indoor range training sessions, maintaining those pesky pests or sport shooting from small game to casual plinking. Blazer is a great alternative to reduce the cost of practice shooting, while it continues to bring shooters quality and reliability. If you want great, dependable ammunition, without the high-end cost, think Blazer.


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May 3, 2012
Unist Inc., Grand Rapids, Mich., has overhauled its website at www.unist.com. New features include easier access to product information and documentation and a growing video library.
The site highlights the company's environmentally friendly lubrication systems and products for metal cutting and metal forming.
Related Company Showrooms:
Unist Inc.
Products in Blanking, Drawing, and Deep Drawing |
News in Blanking, Drawing, and Deep Drawing |


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Product Description
- Tube Material: PVC
- Rated Voltage: AC110V-220V
- Rated Power: 3-11W
- Working Temperature: -40℃ ~ +70℃
- Color: Blue
- With amazing quality and function, you will surprise how good the lamp tape is
- The size of the LED strip is neither too big nor small, and you can carry and use it conveniently
- LED technology is widely used in many fields nowadays, and it makes the flashlight more efficient
- The decoration light is portable and lightweight, and it does not add any extra burden to you
- The LED lamp is perfect for the home or office use
- Great appearance makes the brightest flashlight an ideal choice for your use
- This practical, well-designed LED decoration enables you to have a better living standard
- The size of the strip light is neither too big nor small, and you can carry and use it conveniently
- Every detail of the LED lights is well-made, which you can tell from every inch of it
- The lamp tape is your first choice to own if you want to have one
- The LED lamp tape is perfect for the home or office use
How to Convert Streamlight Flashlight to LED:
A streamlight-brand "C" cell flashlight provides a beam of light courtesy of an incandescent bulb and batteries. Increase the longevity of the light source and the power with which it is being supplied by replacing the incandescent bulb with a white LED. The white LED can be acquired from a hobby store or electronics shop. A few tools will be needed, none of which are unusual to have on hand in most homes. A partial disassembly of the Streamlight flashlight will be necessary
- Place a sheet of newspaper on a table to protect the surface. Unscrew the reflector from the front of the Streamlight flashlight. Push the circular lens out of the reflector with your finger. Dispose of the lens in the trash. Place the reflector aside
- Remove the retaining ring from the front of the flashlight. Place the retaining ring aside. Unscrew the battery compartment cover off the back of the flashlight. Remove the batteries. Place the batteries and the battery compartment cover aside
- Unscrew the incandescent bulb from inside of the front of the flashlight with your fingers. Remove the incandescent bulb from the flashlight. Dispose of it properly
- Insert needle-nosed pliers into the front of the flashlight. Grip the edge of the bulb module with the pliers. Twist the pliers as you pull the lamp module out of the front of the flashlight. Place the module face up on the newspaper
- Heat up the soldering iron for five minutes. Apply a drop of solder to the center contact on the module. Apply a drop of solder to a spot on the contact surrounding the center contact. Let the solder cool for two minutes
- Hold the white LED by the base with the two conductive pins at the bottom facing down. Place the tip of the soldering iron against the solder on the lamp module. Remove the soldering iron when the solder begins to bubble
- Push the shorter of the two conductive pins against the solder on the center contact and the longer of the two conductive pins against the solder on the contact surrounding the center contact. Hold the conductive pins against the solder for 20 seconds before releasing the white LED. Let the solder cool for an additional two minutes
- Grip the edge of the lamp module with the pliers. Reinsert the lamp module into the front of the flashlight. Place the retaining ring on the front of the flashlight. Screw on the reflector onto the front of the flashlight
How to Keep LED from Flashlight:
You grab your flashlight and turn it on, but all you see is darkness. When you open up the battery compartment, you immediately see the problem--the batteries have leaked. Batteries that leak in a flashlight make a mess. If the leak is small and caught right away, it can probably be cleaned up, and the flashlight can be saved. Larger leaks can easily ruin the flashlight. This is a common problem you can avoid by using some smart tactics
- Remove the batteries from a flashlight that is rarely used. You can store the batteries along with the light, but don't install them until you are ready to use it
- Leave the batteries in a flashlight that you have placed in a glove compartment or other place to use in case of an emergency. Remove, inspect, and test the batteries at least every 6 months. If the batteries are run down, immediately replace them. Depleted batteries are more likely to leak
- Replace depleted batteries in a flashlight with fresh, new ones. Don't mix old and new batteries. Use batteries that are the same type, made by the same manufacturer
Package Included:
- 1 x Bunch of LED Road Led Lamp
Customers' Reviews
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03-21-2012- Other Thoughts: This light is rock solid and has served me well. I love this lamp tape.
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01-26-2012- Other Thoughts: Good quality, good Emergency Flashlight, good design for the prices. Very good.
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12-13-2011- Other Thoughts: Excellent. This is just what I want.
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11-17-2011- Other Thoughts: Excellent construction and brightness. Fits easily in a tool bag or glove box. I am a field service engineer and have lost several expensive flashlights so I decided to go cheap just in case I lost another one. I bought 4 of these, and there's nothing cheap about them except the price.
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10-23-2011- Other Thoughts: I love this strip light. I bought one as a gift and fell in love so I had to get one for myself. They are so bright compared to the old traditional Maglites. LED's are taking over the world of darkness.
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10-19-2011- Other Thoughts: I'll keep this short and sweet. A sleek design, lamp tape and made in America equals awesome! This flashlight is rock solid and has served me well. I only buy Mag lite to support the workers in Ontario, California and to support made in America. Quality and pride!
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08-31-2011- Other Thoughts: This is such an amazing flashlight. It is so bright. It is super heavy duty and comes at a great price. Enough said.
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08-23-2011- Other Thoughts: If you would benefit from having a theatrical spotlight in your toolbox, buy this LED strip!!
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- With Mayo Clinic nurse educator
Sheryl M. Ness, R.N.
read biographyclose windowBiography of
Sheryl M. Ness, R.N.
Sheryl M. Ness
Sheryl Ness, R.N., O.C.N., is a nurse educator for the Cancer Education Program at Mayo Clinic in Rochester, Minn. She helps inform patients, families and caregivers about services and resources to help them through the cancer journey.
She has a master's degree in nursing from Augsburg College. In addition, she is an assistant professor of oncology at the College of Medicine, Mayo Clinic, and is certified as a specialist in oncology nursing. Sheryl has worked for more than 20 years at Mayo Clinic as an educator. She has a keen interest in the importance of the quality of life and concerns of people living with cancer.
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Living with cancer blog
Dec. 8, 2009
Cancer survivors have life to celebrate this season
By Sheryl M. Ness, R.N.
4 comments posted
From Black Friday and holiday gift commercials to the beautifully-decorated homes and storefronts, it's hard to ignore — the holidays are now upon us.
While this season is a time for us all to celebrate life and its many blessings, the holidays can also be stressful. A few of my recent stressors include carving out time to bake goodies, purchase and trim the tree and send cards. This past weekend alone, I attended three holiday parties in three days!
Since December has only begun and many of you may be hit by the holiday hustle and bustle like me, I wanted to share some tips that my Cancer Education Program colleagues and I offer cancer survivors to help them take time to enjoy the season, themselves and their loved ones:
Simplify the holidays
- Create a new holiday tradition that makes the most of your energy, such as planning potluck dinners or dining at a favorite restaurant.
- Send seasonal cards or letters after Christmas — try New Year's or Valentine's Day.
- Reduce holiday gift exchanges and shop online or via catalogues when necessary.
- Buy holiday treats to reduce the amount of time you spend baking.
- Reach out for help when needed — for example, ask someone to decorate your home or trim the tree; serve them hot chocolate and the pleasure of conversation in return.
Live in the moment
- Realize your limitations and feel comfortable doing less.
- Don't feel obligated to live up to others' expectations.
- Express your love in more direct ways than gifts.
- Rededicate yourself to your spiritual growth.
Share the hope
- Volunteer at a local nursing home or soup kitchen.
- Donate to a local charity (such as the food shelf) versus purchasing gifts.
- Adopt a needy family.
- Count and communicate your blessings.
- Invite someone to your celebration who you know is alone for the holidays.
Now that I've shared these for everyone to see, I know what my next step is. I need to practice what I preach. Thankfully, I'm sharing this early on in the season, giving me a chance to slow down to celebrate the small things in life, including each day I'm blessed with.
What about you? How do you simplify life and take time to celebrate life during the holidays?
4 comments posted
February 24, 2010 6:10 a.m.
When breast cancer cells spread, the cancer cells are often found in lymph nodes near the breast. Also, breast cancer can spread to almost any other part of the body. The most common are the bones, liver, lungs, and brain. The new tumor has the same kind of abnormal cells and the same name as the primary tumor. For example, if breast cancer spreads to the bones, the cancer cells in the bones are actually breast cancer cells. The disease is metastatic breast cancer, not bone cancer. For that reason, it is treated as breast cancer, not bone cancer. Doctors call the new tumor "distant" or metastatic disease breast cancer hereditary
- jacob
January 11, 2010 12:09 a.m.
No scientific documented evidence exists that 'healing words' are more beneficial than any other words spoken to those living with cancer. Even those people with great faith and devotion die from cancer. But . . human beings are complex creatures and if anything it is the power of the brain that can be most soothing and helpful.
- franadi
December 10, 2009 1:37 p.m.
Alice, Thank you for your feedback -- It's great to know that you found these suggestions helpful after treatment. I hope you take time to celebrate your blessings this season! I also hope you continue to find this blog a meaningful resource. Happy holidays!
- Nicole
December 9, 2009 11:46 a.m.
As a cancer survivor newly released from treatment after five years, I have felt very much unachored now--what to do next? Your suggested have given me a new and clear sense of purpose.
- Alice
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