text:
Windsor 3 Star Hotels + Cheap Hotels + Green
Know When You're Going?
More Search OptionsStar Rating
- 3 Stars
Hotel Amenities
- Meeting Room (4)
- Pet Friendly (4)
- Business Center (3)
- Internet (3)
- Non-smoking (3)
- Swimming Pool (3)
- Dry Cleaning (2)
- Gym (2)
- Restaurant on Site (2)
- Wheelchair Accessible (2)
- Free Parking (1)
- Hot Tub (1)
Hotels by Type
- Cheap Hotels
Best For…
- Green
"We loved the spacious room and found the bed to be extremely comfortable. The pub an... Read more"
"how an amazing place to stay! close to so much! had a great get away with my amazing ... Read more"
"My husband and I booked our hotel for the wrong date so we had to find an alternate h... Read more"
"My wife and I decided to visit Windsor for the Red Bull Air Race. The room we reserv... Read more"
"Nice location. Restaurants in area are expensive but nice, plan to spend a lot for ... Read more"
"My husband and I recently stay at the Radisson in Windsor and we had a fabulous weeke... Read more"
"The location was perfect, and we were able to walk to all of the locations downtown. ... Read more"
"This is a very clean hotel the staff friendly and helpful. The location was ideal to... Read more"
"Had cocktails and a snack in the lounge. Good atmosphere. our room was on the corner ... Read more"
"My boyfriend and I recently stayed at the Hilton for fireworks night. The hotel and t... Read more"
"Being 19 I came with my boyfriend for a good time at the bars, and the young nightlif... Read more"
Note: The nightly rates shown above do not yet include Tax Recovery Charge & Service Fees or (if applicable) Extra Person Fees, Child Fees, Additional Mandatory Hotel Charges or optional incidentals, such as parking, room service or movies.


text:
Baxter school board moves forward with budget cut recommendations
While just half the crowd showed up for Monday night's meeting of the Baxter Community School District School Board of Education as did for last week's town hall meeting, questions from parents and community members made it clear that Baxter values its music program.
Despite this, the board voted to move forward with the 16 recommendations set forth by Superintendent Matt Patton early last week and detailed by the Daily News, with one minor amendment.
In addition to the measures Patton recommended toward cutting $200,000 from the 2013-2014 budget, the board discussed adding a 17th item to the list: eliminating the cost of agenda planners for students by either having parents take over the cost or no longer requiring them.
Story Archived
Please sign in with your Comment Member ID and password.
Having trouble?
If you have any technical difficulties, either with your username and password or with the payment options, please contact us by e-mail at firstname.lastname@example.com

subset: commoncrawl


text:
Select a tag to browse associated projects and drill deeper into the tag cloud.
A bunch of C++ classes/libraries, primarily for use with openFrameworks. There is an un-official mirror at http://github.com/of/ofx-msa/tree/master (courtesty of lian) where you can download a zip if you don't fancy messing around with SVN ofxiPhoneThis allows openFrameworks 006+ to run on
Copyright © 2013 Black Duck Software, Inc. and its contributors, Some Rights Reserved. Unless otherwise marked, this work is licensed under a Creative Commons Attribution 3.0 Unported License . Ohloh ® and the Ohloh logo are trademarks of Black Duck Software, Inc. in the United States and/or other jurisdictions. All other trademarks are the property of their respective holders.


text:
Share on:
Tongue cancer is a common and serious type of mouth cancer (oral cancer). Tongue cancer usually begins in the squamous cells that cover the surface of the tongue. When cancer forms in the front two-thirds of the tongue, it's classified as a type of oral cancer. Cancer that develops in the back third of the tongue is considered a form of throat (oropharyngeal) cancer.
When identified early, tongue cancer is highly curable. Oral cancers are about twice as common in men as in women. Tobacco, heavy alcohol use and exposure to human papillomavirus (HPV) increase the risk of oral cancers.
Mayo Clinic in Rochester, Minn., is ranked among the Best Hospitals for cancer by U.S. News & World Report. Mayo Clinic in Jacksonville, Fla., and Mayo Clinic in Scottsdale, Ariz., are ranked high performing for cancer by U.S. News & World Report.
At Mayo Clinic, we assemble a team of specialists who take the time to listen and thoroughly understand your health issues and concerns. We tailor the care you receive to your personal health care needs. You can trust our specialists to collaborate and offer you the best possible outcomes, safety and service.
Mayo Clinic is a not-for-profit medical institution that reinvests all earnings into improving medical practice, research and education. We're constantly involved in innovation and medical research, finding solutions to improve your care and quality of life. Your doctor or someone on your medical team is likely involved in research related to your condition.
Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care — and trusted answers — like they've never experienced.
Why Choose Mayo Clinic
What Sets Mayo Clinic Apart
Read more about mouth cancer.
A tongue tumor threatened to cut short this volunteer firefighter's life, but surgery and radiation treatment at Mayo Clinic saved his life.
Mayo Clinic's Cancer Education Center offers education and support for cancer patients and their families and friends.
Mayo Clinic ENT surgeon Eric Moore, M.D., discusses and demonstrates transoral robotic surgery for the treatment of tonsil and base of tongue cancers. Watch video on YouTube.
Share on:


text:
CALL US on +91-8121004004
Email: email@example.com
Book Newspaper Classified / Display Ads in Local / Regional / National
Newspapers of India. We are Advertising Agency serving Ad Rates &
bookings for more than 100 leading publications.
Newspapers of India. We are Advertising Agency serving Ad Rates &
bookings for more than 100 leading publications.
The Sangai Express is a famous English Newspaper published from Manipur.
Bhaves Advertisers books advertisements for The Sangai Express. We book Display, Appointment Ad, Tender Notice, Public Notice, Classified Display, and all other types of advertisement categories. You can give or publish your ad in The Sangai Express through us. We offer special discount on tariff rates.
Editions of The Sangai Express
The Sangai Express is published from Manipur.
We book ads in the following newspapers
+ English Dailies
+ Financial Dailies
+ Hindi Dailies
+ Telugu Dailies
+ Marathi Dailies
+ Tamil Dailies
+ Bengali Dailies
+ Malayalam Dailies
+ Kannad Dailies
+ Gujarati Dailies
+ Oriya Dailies
+ Urdu Dailies
+ Punjabi Dailies
We accept
We book ads in the following Categories in the above news papers
Payment Option
We accept payment through net-banking or direct deposit in our HDFC Bank Account.
To know more details Click here
Newspaper Advertising Tips
Here are some tips for newspaper advertising


text:
Eden Manor
154 Post Rd.
South Kingstown, Rhode Island 02879
Map This Location
Email: Use the online form to contact this property
Web Site: http://www.edenmanorbandb.com
Twenty-six-room Victorian estate built in 1868. Large guest rooms, many with fireplaces, eleven-foot ceilings and sweeping lawn. Close to Rhode Island's world famous beaches, Block Island Ferry, historic Newport and the University of Rhode Island.
Services / Features / Restrictions: Accommodation, Bed and Breakfast, Bath, Fireplace, Shared Bathroom, Smoking Areas Available, South County
Handicap Service: Contact property for current services


text:
Urology Program
Our health care professionals treat urologic diseases and defects in children of all ages medically and surgically at Children's Hospital of Wisconsin. Pediatric urologists, nurse practitioners and nurses have the training to care for children's unique physiology and age-related problems.
Newborns and infants, particularly, can pose a variety of challenges requiring the expertise of pediatric urology specialists. These children also may need immediate access to the full spectrum of other specialties provided only at a state-of-the-art pediatric medical center.
Advanced specialty services available to urology patients at Children's Hospital include radiology, anesthesiology, surgery, nephrology, oncology, neonatal intensive care and pediatric intensive care.
Because children often undergo months or years of follow-up care, doctors at the hospital work closely with referring physicians.
Our team of specialist are internationally known. Our Urology Program is led by John Kryger, MD, former director of Pediatric Urology at American Family Children's Hospital in Madison, Wis. Dr. Kryger has held leadership roles in health care and a variety of professional organizations, including the Society for Fetal Urology.
Video: Meet Dr. Kryger and learn about our Urology Program
Children's Urology Program is capable of caring for the sickest children, including newborn babies who require surgery right after birth. We also are the only pediatric hospital in Wisconsin using robot-assisted laparoscopic surgery, a type of minimally invasive surgery.
We are committed to measuring the safety and quality of our urology care so we can make it even better. We share this quality information about our urology program, as well as many other programs.
We offer:
- Prenatal counseling for hydronephrosis, multicystic dysplastic kidney and congenital abnormalities.
- Emergency care of acute conditions, such as testicular torsion, genitourinary tract trauma and neonatal problems.
- Treatment for congenital urinary tract abnormalities, including ureteropelvic junction obstruction, duplex systems/ureterocele, vesicoureteral reflux (VUR) and posterior urethral valves.
- Surgical reconstruction of genital conditions, including intersex issues, bladder exstrophy and epispadias, hypospadias, undescended testis and hydrocele.
- Treatment for common urinary tract problems, including incontinence, infection, enuresis, kidney stones and tumors.
- Treatment for bedwetting and urinary incontinence, through our Voiding Improvement Program.
In conjunction with The Medical College of Wisconsin and the Blood Center of Wisconsin, the pediatric urologists at Children's Hospital constantly are researching better treatments, enabling them to stay on the cutting edge of the latest therapies. Inquiries from patients, families and health care professionals are welcome.
Urology services are available at:
Children's Hospital of Wisconsin, Milwaukee
Children's Hospital of Wisconsin Fox Valley Clinic
Children's Hospital of Wisconsin Green Bay Clinic
Children's Hospital of Wisconsin Kenosha Clinic
Children's Hospital of Wisconsin New Berlin Clinic
Surgicenter of Greater Milwaukee (surgery location only)
Why choose us?
We believe patient families have a right to know what level of care we provide. Review our quality and outcomes reports.


text:
Reach more than 100,000 professionals a month that are focused on green building
#1 authority on residential green building construction
GreenBuildingAdvisor.com draws on 25+ years of experience publishing residential construction information.
The site provides the most useful, accurate, and complete information about designing, building, and remodeling energy-efficient, sustainable, and healthy homes.
GreenBuildingAdvisor.com provides all the real-world toolsqualified green products, design and construction details, and the practical knowledge of our editors and communityin one place.
Who are "Green Building Advisors"
All of the editors at GreenBuildingAdvisor.com are former builders, remodelers, and designers. These industry experts recognized the need for a single resource where design and construction professionals and knowledgeable homeowners can get the full complement of the information and insight they need to design, build, and remodel green.
The result is a site providing proven construction details, in-depth how-to advice, a green-products database, green business strategies, design tools, and alternate paths to code compliance together in one place.
The "Green Building Advisors" are 15 of the nation's leading experts on green building, green remodeling, energy efficiency, and building science. The team includes:
- Builder John Abrams of South Mountain Company on Martha's Vineyard
- Building-science authority Joe Lstiburek of Building Science Corp. of Westford, MA
- Remodeling contractor Eric Doub of Boulder, CO, who specializes in carbon-neutral houses and renewable energy
- Architect and green-building materials expert Ann Edminster of Pacifica, CA
- Architect and used building-materials expert Jennifer Corson of Halifax, Nova Scotia
- Building inspector Lynn Underwood of Norfolk, VA
- Developer Vernon McKown of Ideal Homes in Norman, OK
- Remodeling contractor and longtime contributing editor to Fine Homebuilding, Mike Guertin of East Greenwich, RI
- Natural-building expert and structural engineer Bruce King of San Rafael, CA
- Green-remodeling consultant Carl Seville of Decatur, GA


text:
Find Rental Homes Near 4503 Drexel Ave, Orlando
4503 Drexel Ave, Orlando is not currently available on MyNewPlace.
Find Your Rental Home Now
Popular Nearby Rental Homes:
Cities Near 4503 Drexel Ave, Orlando
Using MyNewPlace's home rental search, you can find affordable house rentals in Orlando and the surrounding areas. Our rental house search will display the locations of condos and townhomes as well as single family homes for rent. Try one of the cities below to find your new home.
Orlando House Rentals
Check out some of the great home rental listings in Orlando. Search home rentals like 4503 Drexel Ave, Orlando with MyNewPlace's house rental search or check out the great selection of Orlando, Florida home rentals listed below.
- Quaint home very near Waterford Area 11172 PINEWOOD COVE LANE Orlando, FL 32817 Phone Number: (866) 820-9818
- Orlando, near Downtown Showhomes, America's largest home staging company Orlando, FL 32806 Phone Number: (407) 331-7515
- 3939 Cesare St 3939 Cesare St Orlando, FL 32839 Phone Number: (407) 647-1211
- Lovely 1/1 lake view condo right off Conroy! 5108 Conroy Road Unit 1715 Orlando, FL 32811 Phone Number: (866) 843-3215


text:
Hey guys, I got a brand new in box, seal not broken AMD 3870k I just can not find a use anymore, as I gave my brother my Zbox from Zotac for a computer, and I have a few computers here.
Thought I would ask Bjorn3d.com members before I sold on ebay sometime.
Let me know if interested, as we can talk prices via PM if needed.
WTS AMD 3870k Black Edition
Started by
, Nov 08 2012 03:48 AM
No replies to this topic
0 user(s) are reading this topic
0 members, 0 guests, 0 anonymous users


text:
Media Coverage
Reuters: Zimory and SkySQL Agree Partnership for zimory®scale; the Innovative Cloud Elasticity Tool for Databases [more]
To view the latest media coverage click here
Need More Information?
If you are interested in becoming a Zimory investor and would like to find out more, please contact:
Anja Nemitz
Email: email@example.com
Tel: +49(0)30 609 85 07-0
View Zimory's current investors here.
Gartner named Zimory as 1 of the 5 Cool Vendors in Cloud Management!
Learn more about our technology.
Experton Group recently named Zimory as a Leader for Cloud Service Enablement.
Learn more about Zimory's Enterprise-Grade Software


text:
Seasoned for the Season
Get full flavour for your family – try this hearty Pasta with Blade Roast and Tre Stelle Mozzarella dish.
See the recipePerfect Potluck Pick
This delicious recipe for Roasted vegetable salad with Gunn's Hill Five Brothers cheese is a savoury favourite for potluck get-togethers.
Check out the recipeA Comforting Classic
Our Pork Wellington with Louis D'or Cheese and Beet Sauce is a traditional recipe that will impress guests and family members too!
Watch the video


text: Amigos com Online Personals for Latin Singles around the World Find Single Latino Men and Latina FriendFinder for Latinos, Amigos.com has chat, profile search, and thousands of new members monthly. Meet people in the US, Mexico, Latin America or worldwide. Profiles in English, Spanish, and Portug Worth an Estimated: $105,053 amigos.com |


text:
Ain't that cute? Oh and click on it and it will popout.
- Trinity:
- What did you just say?
- Neo:
- Nothing. Just had a little déjà vu.
- Trinity:
- What did you see?
- Cypher:
- What happened?
- Neo:
- A black cat went past us, and then another that looked just like it.
- Trinity:
- How much like it? Was it the same cat?
- Neo:
- It might have been. I'm not sure.
A government that robs Peter to pay Paul can always depend on the support of Paul.
George Bernard Shaw
Mauris cursus placerat scelerisque. Cras bibendum feugiat felis pharetra vestibulum. Donec mattis porttitor malesuada! Nulla pharetra neque in magna ultrices vehicula ac et augue?
Robots made fireworks at the box office this weekend as Transformers: Dark of the Moon scored the third-best worldwide debut ever with a $372-million take, according to industry figures. In what was the biggest holiday blockbuster take on its opening weekend, the third Transformers movie in the Shia LaBeouf-starring action franchise made an estimated $162 million in North American receipts through Sunday. Box office tracker Exhibitor Relations' analyst Paul Degerabedian Read More ...


text:
Posted 28 August 2006
Return to Discussion Text
Live discussion held 19 November 2002. Led by Tobias Hartmann of the University of Heidelberg, Germany.
Participants: Gabrielle Strobel (ARF); Tobias Hartmann; Alexei Koudinov; Ben Wolozin; Weiming Xia; Detlef Schmicker; Gunter Eckert ; Gunnar Gouras; Claudia Almeida (Cornell Medical College, New York); Jim Brown (Loyola UMC in Maywood, Illinois); Reisuke Takahashi; Cassie Theisler (Maywood, Illinois); Frank Pfrieger; Christof Antz; Marcos A. Marques.
Gabrielle Strobel Let's start, perhaps, with a basic question: Do people with AD generally have elevated plasma cholesterol, or are we talking about two different pools of cholesterol here, one central, one peripheral? Are we treating to lower neuronal- and glial-derived cholesterol?
Alexei Koudinov I think that there are two pools that, of course, interact with each other. But how? Still remains to be investigated.
Tobias Hartmann Well, certainly not everyone has high cholesterol; we see this in the studies. The idea is that it is high when deposition starts.
Ben Wolozin My sense is that the linkage between serum cholesterol and AD is weak.
Tobias Hartmann What we want to treat depends on opinion. I think one should treat neuronal cholesterol; Larry Sparks thinks that is dangerous and one should go for peripheral cholesterol lowering.
Gabrielle Strobel Tobias, the increased CSF 24S-hydroxycholesterol that you measured in AD patients appears to be brain-derived cholesterol. Is more of it synthesized in the brain and transported out, or is there something wrong with its degradation?
Tobias Hartmann We don't know this yet; my guess is that lipid homeostasis is altered the more you advance in the disease. That may be unrelated to the treatment.
Alexei Koudinov Am I correct that while talking about 24S-OH cholesterol, we still are talking about its lipoprotein transport?
Ben Wolozin Tobias and Alexei, people I have talked to, seem to feel that even though 24-OHC is referred to as "more soluble," it is still attached to lipoproteins such as ApoE.
Tobias Hartmann 24S is bound to proteins, like almost all lipids, it is not "freely" available.
Alexei Koudinov What seems to be true is that even mild-to-moderate and chronic changes in systemic lipids (and cholesterol in particular) affect their brain pool.
Ben Wolozin There is also the possibility that using statins to treat neuronal cholesterol gets at neuroinflammation and ApoE in the process.
Gabrielle Strobel Ben, I am confused about the antiinflammatory connection: Statins are antiinflammatory, they reduce Aβ production, some NSAIDs are said to work by reducing Aβ production—that can't be all there is to it?
Tobias Hartmann Ben, I agree again, [neuroinflammation and ApoE] may or may not be linked to Aβ.
Gabrielle, we definitely know that lowering cholesterol without statins or NSAIDS lowers Aβ.
Gunter Eckert Tobias, to follow up on Gabrielle's point, cholesterol lowering [drugs] reduce Aβ in vitro, but the clinical studies failed to show an effect on AD progression for cholesterol lowering drugs other than statins.
Tobias Hartmann Gunter, yes, I think this is an very important point—do you think because they are weaker? What do you think, Ben?
Ben Wolozin Tobias and Gunter—yes, I agree that the only strong data is for statins. Although I never published it, I examined cholestyramine (which binds cholesterol in the gut) and it had no effect on AD, but the numbers were small.
Alexei Koudinov Ben, some people in the lipid field (not neuroscience/AD) whom I talked to think lipoprotein transport is still involved in 24OH-cholesterol.
Ben Wolozin Alexei—I agree that LP transport must be important.
Gabrielle, check out the recent paper in Nature showing protection by statins against experimental allergic encephalitis. While I strongly believe that statins are mainly affecting cholesterol in AD, there is clearly evidence that statins affect inflammation as well, and it would be unwise to ignore that angle.
Gabrielle Strobel That's a mouse model for multiple sclerosis?
Ben Wolozin Yes.
Alexei Koudinov Ben, the encephalitis story may refer to multiple sclerosis (MS) related models linked to myelin pathology.
Ben Wolozin Alexei—yes, but immune driven. However, I do NOT want to steer this chat room towards inflammation! So, let's get back to cholesterol.
Alexei Koudinov Ben, exactly, that's what I mean—with an immuno-related pathology.
I assume we all saw the recent Neurology paper by Fassbinder (Fassbinder et al., 2002) on no change in Aβ after statin treatment.
Tobias Hartmann Alex, the Fassbender neurology study has one major problem: No AD patients and, importantly, no baseline samples. The (expected) small lowering of Aβ levels would not be detectable in such a study.
Gunter Eckert Well, regarding the statins, I think that there must be a story behind lowering cholesterol; even the reduction of cholesterol is an important point.
Tobias Hartmann Gunter, we should also keep in mind that Larry Refolo lowered aβ in mice without statins.
Gunter Eckert Even in cell culture you need high statin concentrations to observe an effect on Aβ...
Alexei Koudinov Gunter, that's what other people suggest, too (see the Neuroreport article by Yasojima et al.,2001).
Gunter Eckert ...also in the mice we needed big doses of statins to lower CNS cholesterol levels.
Ben Wolozin It is important to note that Karen Duff used a different lipid lowering agent (in a Tg mouse model) and saw lowering of Aβ and a reduction in plaques.
Alexei Koudinov ...as well as Sparks' data on rabbits when Aβ fell after stopping the cholesterol diet (see Sparks,1996).
Gunter Eckert Ben, you are right and this argues for a second effect of the statins in AD.
Tobias Hartmann Gunter, Ben, probably all comes up to how long and how strong the treatment is. In humans treatment is long but at low concentrations. In animals it was just the opposite.
Gunter Eckert Tobias, that is an important point and we have to keep in mind that the pharmacology in the animal model is quite different from humans.
Tobias Hartmann Gunter, very [different].
Ben Wolozin Gunter—do you think that ApoE is the main mechanism by which statins act on cholesterol in the brain?
Gunter Eckert Ben if not the main, it definitely plays an important role, as we learned from our animal experiments.
Alexei Koudinov Ben, I think many mechanisms are involved, all serving the maintenance of particular (i.e. very individual) cholesterol dynamics needs in the brain and brain regions.
Ben Wolozin Alexei, then how do you account for the absence of an effect of lovastatin in Gunter's ApoE -/- mice?
Alexei Koudinov I believe that there is a complicated interaction that is not limited to the brain tissue. It is possible that some systemic changes are mediated to the brain...causing some changes (or the lack of changes) that we can not explain yet.
Gabrielle Strobel Tobias, I understand that in your pilot clinical trial, simvastatin reduced Aβ40 but not 42 in CSF? How do you interpret this?
Tobias Hartmann Gabrielle, we saw the same decline but more variable. You can find it in the paper.
Gabrielle Strobel In the trial, did you do cognitive tests, and did you see changes?
Tobias Hartmann Gabrielle, I want first to bring in a word of caution. We did this clinical study but on purpose we call it a pilot study and we definitely want to see independent confirmation.
Actually, the pilot clinical study was designed as a proof of principle study: Are statins capable of lowering Aβ levels? It just turned out that there were also cognitive changes. We had not anticipated this originally and have not put in all thinkable power to address cognition. To me this remains an open question. There was an increase in MMSE but not ADAS-Cog.
Gabrielle Strobel Tobias, is the CSF 24S-hydroxycholesterol elevation specific enough to be a biomarker, like phospho-tau appears to be shaping up? Is this worth pursuing?
Tobias Hartmann Gabrielle, it is a good marker for the treatment, less good as a general marker for AD diagnosis.
Gunter Eckert Regarding ApoE: There is no doubt that this apolipoprotein is one of the most important risk factors for the disease. The 4/4 [genotype] is strongly connected with AD. We now believe that this ApoE 4/4 is malfunctioning.
Ben Wolozin Gunter, yes. Classically it is thought to increase Aβ aggregation, but to me it seems the fact that it is a risk factor for many types of neurodegeneration suggests that it might be operating through a mechanism more related to its cholesterol function.
Gunter Eckert Ben, this in my impression too!
Knockout ApoE animals and animals that carry the human ApoE 4/4 show many similarities regarding parameters linked to brain cholesterol.
Ben Wolozin Gunter—so are you saying that you don't think that ApoE has a strong effect on brain cholesterol? Gunter—what about plasticity (the classic meaningless catch-all term!!).
Gunter Eckert Without question, ApoE is important especially for brain cholesterol metabolism.
Alexei Koudinov Gunter, we have some related refs on ApoE4/cholesterol changes in ClinMed article accessible via our ARF hypothesis page. As for Ben's note, I agree with the primary importance of the ApoE allele for neurodegeneration through cholesterol dynamics (see previous ARF live discussion). For example—see Chapman et al.,2001 on role of ApoE in multiple sclerosis.
Gunter Eckert Alexei, thanks I will have a look at it.
Ben Wolozin Weiming—are you looking at cholesterol?
Weiming Xia Ben, we have not looked at cholesterol, but are curious about Kovacs' findings on ACAT inhibitor effect.
Alexei Koudinov Weiming, we have the letter commenting on Dora Kovacs' article published at British Med J.
Another thing I wanted to remind the audience about with special regard to Dora's comment on Tobias's background text for this discussion, that is a recent Neurology (2002) article (Gaist et al., 2002) reporting on polyneuropathy in statin users.
Tobias Hartmann All, I think the mechanism of how cholesterol affects aβ production in cells is pretty much unresolved. I do not think that it directly interacts with the secretases, any opinions on this?
Ben, you think the a secretase effect is real or is of relevance in vivo?
Ben Wolozin Tobias—I'm not sure. The fact that you see a lowering of Aβ is significant and implicates secretases, but doesn't prove it.
Weiming Xia Tobias, I do not know if there is any direct effect on secretases. Bill Klein proposed its effect on a-secretase in 96, and later Urmoneit et al. talked about g-secretase. I do not see any more evidence showing up.
Gunter Eckert Regarding the secretases we have to think about one factor: time...
Weiming Xia If g-secretase cuts LRP, which binds ApoE, would this connect cholesterol to secretases?
Tobias Hartmann Weiming, it makes a lot of sense for g secretase to be regulated this way. But then LRP is not only processed by g secretase.
Ben Wolozin Weiming—wouldn't the g-secretase cleavage be constitutive?
Weiming Xia Ben, it is no longer constitutive when you think of Aph-1 and Pen2, Nicastrin.
Tobias Hartmann Ben, yes, g secretase is constitutive as far as we know. Maybe this is a challenge and Aph-1 etc. are also constitutive (until now).
Ben Wolozin Weiming—true. I guess the question is how g-secretase affects trafficking of LRP, and whether this affects cholesterol. Any thoughts?
Gabrielle Strobel Tobias, I understand that sorting and trafficking of cholesterol between different membrane compartments, and between membrane cholesterol and cholesterol ester pools, somehow affects APP processing. How could this work?
Tobias Hartmann Gabrielle, this appears to be trafficking of secretase and substrate into the same compartment. The question is, why is γ-secretase in a very specific cholesterol sorting compartment?
Alexei Koudinov Weiming, our referenced BMJ and other letters are accessible at our own web site.
Weiming Xia Thanks, Alexei.
Tobias Hartmann If we would find a true regulation for g-secretase activity, it may give us a lead to overproduction of aβ in AD.
Ben Wolozin Weiming—any insights from your end?
Gabrielle Strobel Gunter, where do the lipid rafts come in here? Do we know significantly more now to shed light on their role, other than that they contain the players of APP processing and high cholesterol?
Gunter Eckert Gabrielle, I learned at the neuroscience 2002 that we should see the rafts in a more functional way—and this is only poorly understood yet.
Weiming Xia Ben and Tobias, if indeed PS1 affects APP trafficking to the cell surface and re-internalization, similar effect could happen to LRP.
Tobias Hartmann Weiming, …and cholesterol affects PS trafficking.
Ben Wolozin To the group (since Dora isn't here): Any ideas why cholesterol esters would increase Aβ production?
Gabrielle Strobel My thought exactly, Ben, thanks.
Alexei Koudinov Ben, this question was puzzling me a year ago, and I guess I addressed it in the BMJ letter.
Gunter Eckert Small changes in the composition, especially in cholesterol, in compartments hosting the secretases will lead to enhanced Aβ levels during the time.
Ben Wolozin Gunter—but my understanding is that cholesterol esters are stored in special lipid compartments—which are different than where the β and γ-secretases are located.
Gunter Eckert Ben that's true, I talked about unesterified cholesterol.
Tobias Hartmann Ben, lipid droplets should be enzymatically inactive, but they still affect the total lipid homeostasis of a cell. But maybe, therefore, looking specifically on cholesterol and esters is misleading.
Gabrielle Strobel Tobias, why is that misleading?
Tobias Hartmann Gabrielle, because the active molecule may not be cholesterol but another lipid influenced by cholesterol levels or another protein.
Alexei Koudinov My belief is that Aβ is involved in this interaction by modulating cellular/membrane cholesterol, so, both cholesterol and Aβ (and APP processing) affect each other. (See Michikawa et al.; Chochina et al.; and Koudinov et al.)
Tobias Hartmann Alexei, I am waiting for experiments not using synthetic aβ, but cell- generated aβ, to prove this point.
Alexei Koudinov I got your note, Tobias.
Ben Wolozin Tobias—perhaps the accumulation of cholesterol esters in lipid droplets affects Aβ production indirectly, via feedback?
Tobias Hartmann Ben, YES!
Gabrielle Strobel In her comment, Dora Kovacs mentioned these alternatives to statins for cholesterol management: extended-release niacin, cholesterol absorption inhibitors, ACAT inhibitors, cholesteryl ester transfer protein (CETP) inhibitors. Do any of you know of their status?
Ben Wolozin I have heard that niacin also lowers Aβ, but not as well as statins.
Tobias Hartmann Gabrielle, I am afraid how long it will take before they can be used. But there is a lot of money in this for companies.
Tobias Hartmann Ben, fascinating and these are less active in lowering cholesterol. Would make some sense.
Ben Wolozin Yes, Gloria Vega in Texas has done this work.
Okay, so what else should we chat about?
Weiming Xia Does niacin cross the blood brain barrier(BBB)?
Ben Wolozin Weiming—I don't know.
Gabrielle Strobel Since we have you here, Frank, let me ask everyone this question about synaptic dysfunction in early AD: Bill Mobley (Lynch et al.,2000) and you, Alexei (See Current Hypotheses), propose that AD results when disrupted cholesterol uptake and metabolism changes trafficking of membrane proteins needed for synaptic plasticity. This is also where perhaps altered APP processing would fit in. Since Frank Pfrieger showed that neurons need cholesterol and ApoE secreted from astrocytes, would this make AD a glial disease?
Alexei Koudinov Gabrielle, thanks for this point. I submitted a comment on this matter. The idea is that synaptically released Aβ, and changed APP processing, may well fit the lipid-related function of Aβ (see links above) as was 'similarly' shown to other Apos, ApoE and ApoJ last year, by Horsburgh et al..
Tobias Hartmann Frank, do you think statins could ever lower cholesterol in brain to a dangerous level before the other statin side effects set in? The clinical studies indicate that this is not possible in adult brain.
Weiming Xia Tobias, if simvastatin is well tolerated in adult brain, it seems fine.
Ben Wolozin Tobias there is a study from Finland showing that individuals with very low serum cholesterol are actually at increased risk for cognitive decline (presumably not due to AD!).
Tobias Hartmann Ben, yes, but this is indicative not only of cholesterol but also a lot of other things, and they have lowered cholesterol also in the developing brain. And we know that cholesterol is very important in development and later cognitive decline.
Frank Pfrieger Our hypothesis is that neurons shut down their cholesterol synthesis at least in the adult stage and depend on supply by astrocytes via lipoproteins. If true, then any interference with intercellular transport could cause problems. Lipoproteins bearing the ApoE4 allele may well be less capable of transporting cholesterol to neurons. Although I could imagine that other factors play a role. What I really wonder is whether Aβ interferes with the extracellular lipoprotein shuttle.
Alexei Koudinov ...regarding glial disease, I am not sure. Both glia and neurons tightly interact to do their job...Frank, we and others showed that Aβ affects cholesterol uptake by neural tissue (see refs above on lipid related function of Aβ).
Gabrielle Strobel Alexei, I agree, I was being a bit facetious to stir things up...
Cassie Theisler About the glial response, wouldn't one expect malfunction or changes (inflammatory responses) to occur in response to the disease state, how would you decipher which came first?
Alexei Koudinov Ben/Tobias, and what about low cholesterol and increased suicide rate?
Ben Wolozin Alexei—I think that there is no question that cholesterol has a huge impact on many factors in the brain. This is why the drug companies have focused on developing statins that don't impact on the brain (until they learned about AD).
Tobias Hartmann Alexei, that has not been confirmed. But there is a higher violent death rate (murder), which I think was also not confirmed. I think this is a remote issue and I get depressed if I am not allowed to eat my burgers.
Ben Wolozin Tobias—well, BSE will get you first then!
Gabrielle Strobel Tobias, do you know why Bayer's statin was withdrawn? I've read mention in a press story about rare demyelinating side effects but probably there is more to this? Can you clarify rumors?
Tobias Hartmann Gabrielle, the Bayer drug was withdrawn because Bayer could not stop the misuse (which they first propagated themselves).
Alexei Koudinov Gabrielle, the drug withdrawal was based on a myopathy problem (Kind et al.,2002) that points to a special role for cholesterol at neuromuscular junction.
Weiming Xia If atorvostatin does not cross the BBB, it may only reduce serum cholesterol without affecting brain cholesterol levels. Correct me if I am wrong.
Tobias Hartmann Weiming, but how would it work in the brain, if it does not lower brain cholesterol....and if it does not enter the brain, it should also not be antiinflammatory in the brain.
Alexei Koudinov Gabrielle/Frank, we think a bit different. We believe that lipoprotein transport is critical for fast delivery of cholesterol for short-term plasticity, while neuronal cholesterol synthesis serves long-term plasticity demands (see article in FASEBJ Koudinov et al.).
Gabrielle Strobel Tobias, about the question whether statins that cross the BBB are more dangerous than those that don't. There must be voluminous records on the many thousands of people who have taken different statins for years. Do you know what they say?
Tobias Hartmann Gabrielle, to the best of my knowledge, there is no relevant difference in the six different statins when it comes to side effects. Most big studies have been done with simvastatin.
Frank Pfrieger Concerning the statin issue: The question is even for those that pass the blood-brain barrier how much actually enters the brain, since a certain fraction is absorbed by the liver.
Tobias Hartmann Frank, correct, most of the statin stays outside the brain anyway.
Gabrielle Strobel But then what do they act on, Tobias? Serum cholesterol? Astrocyte cholesterol? I am confused.
Tobias Hartmann Gabrielle, neurons and astrocytes.
Gabrielle Strobel We are nearing the end of the hour but you all can continue chatting for as long as you like (or until the burgers beckon to our European contingent, it's dinnertime there). Before people start leaving, let me thank everyone for coming today. This is an important topic and we will certainly follow up with another chat in a year or two.
Alexei Koudinov Frank: ...I believe the statins that do not pass the blood brain barrier (but affect liver cholesterol status) also change brain cholesterol via yet not elucidated mechanisms.
Tobias Hartmann Alexei, that is not what the FDA says.
Ben Wolozin Tobias and Weiming—a vascular drug could affect cholesterol via ApoE.
Tobias Hartmann Ben, that is a good experiment.
Weiming Xia If we consider the hypothetic "drainage" model for the Aβ antibody vaccine, can cholesterol work in a similar way?
Tobias Hartmann Weiming, nope, because hardly any aβ in plasma is produced in plasma. So I think this mechanism would not be affected by statins (as little as we know about this now).
Ben Wolozin Weiming—I think the drainage model is a good point, except that I think many statins do not lower cholesterol in mice, but they do lower plaques.
Weiming Xia We should have another discussion on CAA with passive vaccination.
Gabrielle Strobel That is a great idea, Weiming. Would you please email me about it, email@example.com, to help me plan it?
Alexei Koudinov Weiming: ...this was a matter of AlzForum news some time ago...following a meeting report. See our comment on the ARF news item and its other comment.
Frank Pfrieger The synthesis issue in neurons: In my opinion there are no convincing data yet showing cholesterol synthesis in neurons at the adult stage.
Gabrielle Strobel What is the link between cholesterol and tau? Do not Niemann-Pick mice have neurofibrillary pathology?
Alexei Koudinov Good we recall this subject. Yes, NPC mice has TAU changes, but Aβ changes, too.
Our explanation for tau changes is the one described in our last year study (see above for ref). We extended to hippocampal slices the cell culture findings of Fan et al. Furthermore, these data were further validated by several reports at the 31st SFN meeting '2001 in San Diego.
Gunter Eckert Gabrielle, Fan et al. showed that mice develop NFT when they are treated with cholesterol lowering drugs.
Gabrielle Strobel Gunter, why?
Gunter Eckert Gabrielle, I do not know! But there must be a link.
Alexei Koudinov I have an explanation why cholesterol depletion increase tau phoshorylation in hippocampal slices.
Gabrielle Strobel Alexei, what did you find?
Tobias Hartmann Gabrielle, a side pathway of the cholesterol biosynthetic pathway appears to be essential for this tau pathology. It is a study by Ohm.
Gabrielle Strobel Right Tobias, I wish Thomas were here today.
Tobias Hartmann When Ohm blocks specifically the geranyl/geranyl/pyrophosphate pathway, he gets alterations in tau phosphorylation. This is independent of cholesterol.
Gunter Eckert Yes Tobias, that is the point!
Frank Pfrieger Concerning the Fan et al. study as well as others: One possible reason may be the breakdown of axonal transport. As you may know, there is a paper from Klopfenstein et al. showing, with a clever in vitro assay, that kinesin-mediated transport of vesicles depends on a sufficient cholesterol level in the vesicle membrane.
Alexei Koudinov ...I think that tau changes are a more general reaction, not limited to the break in cholesterol dynamics.
We also have to remember that excessive tau phosphorylation occurs normally during early ontogenesis.
Gabrielle Strobel Frank, can you provide a citation, or journal?
Frank Pfrieger Avec plaisir: It's Klopfenstein et al., 2002, Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell 109:347-358.
Alexei Koudinov ...recall PD, it also has tau changes in some cases, but we are not talking (yet, at least) about cholesterol changes there...so, I should get to the major point: As synaptic function is affected, neurofilaments change, and tau reacts. This was first suggested in 1991 by Perry et al. We further discuss it with relation to the break of plasticity due to cholesterol modulation in the FASEB J 2001 article (link is above).
Gabrielle Strobel Many lines of evidence are converging on axonal transport these days, of APP, kinesin's role as APP receptor, tau elevation effect on inhibiting kinesin docking, now cholesterol Tobias, what do you think of this?
Tobias Hartmann Frank, Gabrielle, do you think cholesterol levels, as much as we can lower them in vivo, could affect axonal transport?
Gabrielle Strobel Is there any way of finding out what the RIGHT cholesterol levels are in an adult human? Adult human brain, that is.
Tobias Hartmann Gabrielle, I am not aware of a verified lower limit for plasma cholesterol, and I doubt this is known for brain.
Gunter Eckert Regarding the RIGHT cholesterol concentration: We only have data from post mortem brain samples...and usually they are determined from brain homogenates.
Tobias Hartmann Gunter, and this is?
Gunter Eckert Definitely we could not learn so much from it.
Tobias Hartmann Gunter, I agree postmortems tell us little what is causing the disease.
Gunter Eckert Even because there are only marginal differences between tissue from AD and controls regarding cholesterol levels!
Alexei Koudinov Gabrielle, we have a good ref at Noteworthy collection of the Neurobiology of Lipids: The importance of both actin and tubulin for the transport. It is a very recent article of just few days ago. The dynamics seem to be important.
Gunter Eckert Alexei, that is also my point.
Alexei Koudinov ...that's where the study of the dynamics can show greater difference (if any).
Here is the ref I talked about: Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton. See Mundy DI et al., 2002).
Gabrielle Strobel The key differences may be between a sick neuron and a nearby neuron that is still functioning okay, which you would never see with homogenates. Did cholesterol-related genes come up in studies of transcriptional profiling?
Alexei Koudinov Gabrielle, you bring up an important issue: What is the sick state for a particular neuron? Is it constitutively sick due to genetics, dietary habits, or just because it needs extra cholesterol while building memories, or because it did not consume cholesterol (due to no activity) available to it?
Gabrielle Strobel Alexei, I just mean that perhaps microarray studies of transcriptional changes of message amplified from very small samples, even individual postmortem cells, might point to differences in lipid metabolism in affected vs. still-healthy neurons..
Gunter Eckert Alexei, these studies can show greater differences—also in post mortem brain samples from human (unpublished data).
Tobias Hartmann There was an interesting poster by Mattson showing no difference in MCI but increasing differences the further AD progressed in various lipids, indicating that postmortems will show us the response to AD, not the cause.
Alexei Koudinov Gabrielle, by the way, the genetics issue is covered in our Neurobiology of Lipids abstracts article Frankfurt, Germany Meeting (26 July 2002) on "Cholesterol and Alzheimer's". It is by Fabienne Wavrant-DeVrieze who works with J Hardy.
Gabrielle Strobel Tobias, all, let me rock the boat a bit: Many researchers remain unconvinced that cholesterol and lipid homeostasis play a primary or early role in AD pathogenesis. They believe it is one of the innumerable things that are dysregulated as a consequence of the disease. What's the key, strongest evidence that makes cholesterol effects stand out?
Gabrielle Strobel Tobias, but you think that elevated cholesterol is important presymptomatically, during midlife? Does this fit?
Tobias Hartmann Gabrielle, as I said, cholesterol may not be the very molecule doing the trick. But the best point that lipids are very relevant for AD is that lipids are the only molecules (nonsynthetic, nontransgenic, but biological) that have profound effects on regulating aβ levels in both ways. Lipid levels vary from individual to individual, are taken up by diet, and are known to be influenced by many major and minor factors, like ApoE and others.
Frank Pfrieger Gabrielle, I share your reservations. However, the fact is also that one of the major risk factors is ApoE4, and clearly one, if not the major function of this protein is to shuffle lipids around. So, I think lipids, at least including cholesterol, are in the boat!
Alexei Koudinov Gabriele, I would make another statement: Cholesterol and other lipids are important as much as they construct neural membranes that maintain brain function. As the lipids change, the function change, and we then have Aβ, Tau and many other mechanisms launched to fix this.
Gunter EckertI Alexei, let me add that cholesterol is the main modulator of membrane fluidity and this fluidity is important for all membrane related processes!
Alexei Koudinov Exactly, Gunter, this is another possible mechanism to have the function affected and/or repaired.
Cholesterol change, of course, is just one of several possibilities likely important in AD.
Christoph Antz Does AD correlate with other degenerative disorders like macular degeneration?
Tobias Hartmann Christoph, AD correlates best with vascular dementia.
Gabrielle Strobel I believe a majority of people with AD have some degree of vascular dementia. As a whole, the field seems to be at a loss for how to approach this experimentally?
Christoph Antz I am Christof Antz and my father probably is developing some kind of dementia with possible macular degeneration in both eyes. I just was curious about the coincidence of both forms of degeneration.
Gabrielle Strobel Chrisof, did you see the paper in PNAS recently saying that Aβ was detected in the Drusen of macular degeneration? I am not sure what this means, and it is to be replicated, but there you have a link...see Johnson et al., 2002.
Alexei Koudinov Good point with vascular dementia. We have to talk about it and cholesterol, maybe in another session?
Christoph Antz Thanks, Gabrielle. Does anybody know, if the "mouches volantes" that a lot of people over 40 are developing are probably Aβ deposits? I never saw an analysis of those floating peptides within the eye.
Alexei Koudinov Thanks to Gabriele, June, and Nico, and of course to Tobias for organizing this session.
Tobias Hartmann Okay, I think this was it. We should all stay in contact. Have a pleasant dinner and lunch with lots or little cholesterol, just as you like it.
Gabrielle Strobel Good bye, everyone.


text:
Dolce Vita
Bretta Powwow Tank
Dolce Vita exudes a hip and trendy vibe inspired by Southern California's most stylish and in-the-know trendsetters. The collection exudes effortless cool and Dolce Vita is always on the pulse of the hottest new trends; setting many of their own. In Dolce Vita shoes, you'll always be wearing the most spectacular styles in the hottest colors and silhouettes.
- Poly/rayon blend
- Back keyhole cut out
- Styled with True Religion Faye Embroidered Short in Traveler.
- Styled with Dream Collective Diamond River Cuff in Poppy Red.
- Styled with gorjana Kaia Ring in Gold.
- Styled with gorjana Infinity II Ring in Gold.
- Styled with gorjana Finley Ring Set in Rosegold.
- Styled with House of Harlow Rif Rebble Cuff in Rose Gold.
- Modeled in size S. See fit guide for model's dimensions.
- Revolve Style No. DOLC-WS130
- Manufacturer Style No. BRETTA
- Can't find your size? Place a special order inquiry for this item.
Potomac MD
Some Curves/Average Height
Yep, light and airy because the straps are so long it basically leaves my chest exposed. Cuts the body horizontally at a strange place and though the picture shows it covers the model's tush, it didn't dover mine and I am only 5'4. Runs large as I purchased a small and it was too large everywhere.


text:
Thursday, 21 October 2010
EFM Gym Dandenong, onsite at Southern Health Dandenong has announced a site relocation to a new club space, still within Dandenong Hospital. The new space for EFM Dandenong will be located on Level 1, which is directly located opposite the hydrotherapy pool one level down from current gym location.
Dozens of EFM members from clubs all over Melbourne recently turned out for a few hits and giggles at the Annual EFM Tennis Day. The event took place at the home of tennis, Melbourne Park, on Sunday 14th February.
The annual EFM Health Clubs Triathlon for SA EFM members has been swam, rode and run (of course with loads of fun)! Over 300 members turned out at EFM Westlakes to brave the early morning and cold water.
Having opend 11 clubs in just over 12 months and with plans for further expansion in the coming six months, EFM Health Clubs has been listed as the 30th fastest-growing franchise by revenue and 23rd for outlet growth (number 1 fitness gym franchisee in Australia) in the 2010 list.
Novita Children's Services has been named as the charity of choice for EFM Health Clubs. EFM, now 60 clubs across Australia, announced this week that its various fundraising efforts throughout 2010 would benefit Novita, the not-for-profit service provider for South Australian children with physical disabilities and their families.
Online Exclusive Register here for your 3 free sessions!
Read more


text:
Stocking Stuffers - Computers & Electronics
Gift Buzz
We have the hottest tablets for kids, including Tabeo, Kindle Fire and LeapFrog LeapPad, as well as all the big trends: Flutterbye flying fairies, cuddly Big Hugs Elmo and fuzzy Furby. Shop from our top gift picks for the most wanted electronic... Read More »
Cool Stocking Stuffers for Teens Read More »
One of my favorite Christmas traditions is stocking stuffer gifts. For me it should always be a mix of fun and practical. There is nothing more disappointing than emptying a stocking only to find batteries and junk that has no real use. When... Read More »
One of the most wonderful things about working in the editorial department of Gifts.com is that I get to sample a lot of the products we feature on the site. But to be honest, when a box of toffee arrived, I wasn't particularly excited because... Read More »
Hand-pickedChristmas Gifts
The Gift Gurus at Gifts.com hand-pick all gift ideas in the christmas category. View great computers & electronics ideas from the top stores online and further refine your results by price, Gift Guru top picks and more to find the perfect gift.


text:
Search for Facebook Fans
Hi! I've searched for a list of all my twitter followers by using Advanced Search > TwitterID Exists - but is there a way to pull a list of all contacts in my Nation with a facebook page?
Official response from Drew CrossIn Advanced Search, in the 'Name and contact' section, checking the 'Info' box under Facebook username will give you all the people that have Facebook info attached to their profile.
Kathy Jacobs responded to Possible to get 1800 or toll free numbers?
with not planned
2012-12-08 15:04:31 -0800
Possible to get 1800 or toll free numbers?
Is it possible to use a toll free number to use with voicemail? I know SMS doesn't work on toll free numbers but I'd love to have one for the voicemail / forwarding.
Official response from not plannedNo, there are not any toll free numbers which can be directly integrated in to NationBuilder. If you feel we should offer them, feel free to suggest it at http://nationbuilder.com/suggest
Jay Smythe commented on How to create a theme for a website with NationBuilder
2012-04-28 19:32:21 -0700
· Flag
Thanks again Jesse!
Jay Smythe commented on Changing Page Background Opacity
2012-04-24 14:53:29 -0700
· Flag
@Jesse Haff was kind enough to post a response on the documentation page here: http://nationbuilder.com/theme_documentation
Changing Page Background Opacity
I've searched the documentation but can't find a way to change the page background opacity.I'd like to customize the Cascade official theme so that blog posts (and all other page types for that matter) have an opacity similar to the Focus official theme.Possible? (I promise to publicly share the theme I develop)


text:
Red state, blue state
Photos by Tim Johnson
All eyes will fall on our perpetually purple state next month to watch which way Ohio sways the presidential vote. Fighting the battle at home, the next generation of politicos has emerged to spread messages of hope and change. Young volunteers and staff members knock on doors, register voters and spend long hours on the phone with undecided voters. They gave up summer vacation, and some took time off school to campaign before the Nov. 6 election. Meet four young people dedicating their time to the campaign this fall.
Niraj Antani was politically active long before he could vote. The son of Indian immigrants fell in love with politics at age 9. He first interned for a public official, U.S. Rep. Mike Turner, at age 16. Now 21, the Ohio State political science major juggles class and campaign activities, such as door-to-door neighborhood canvassing, for Gov. Mitt Romney as part of the Ohio State College Republicans.
What can Mitt Romney do for young people?
I think the main concern students have right now is that every student will graduate. We want to ensure there is a job market available to students. And I think the main issue is ensuring we have a president who knows how to create jobs. Right now that is not the case.
What is your first political campaign memory?
Election night in 2000. I was 9. I didn't know what was going on, but I remember they called it for Bush, and then for Gore. My parents were watching but they went to sleep. I woke them up at 2 a.m. and was like, "Hey, Gore won." Then at 4 a.m., I woke them up and said, "Hey, Bush won." It went on for days and days and I was really confused. Don't they just know who won?
Do you have political aspirations?
I want to run. My parents emigrated from India in the '70s. They moved to America in the hopes that they would be prosperous and wanted their kids to have a better life, and luckily we found that. I got engaged in politics because I care about issues and I see problems and I want to fix them.
Are young people engaged enough in politics?
I think America as a whole is not engaged enough in politics. We should have more people voting. What college students need to understand is that voting matters. If President Obama gets reelected, you will graduate in an economy where you won't find a job.
How are you received on campus?
What you're seeing in 2012 is a lot different than 2008. In 2008, there was a lot of enthusiasm for Obama's campaign. This year, we had 275 people at our first meeting, ready to volunteer, ready to go. The enthusiasm levels are sort of balancing. I'm not going to say we're going to win the college vote, because we're not. Hopefully maybe in four or eight years we'll convince college students that conservative ideals will work for them.
Jacob Manser became a Barack Obama supporter at 15, when he heard him on TV addressing gay rights issues. Manser recalls Obama saying the issues were "too often exploited by people who seek to divide us and that at its core it's about who we are as Americans." Five years later, the Columbus native has taken time off school at Ohio State to work as the LGBT vote director for Obama's Ohio campaign.
What do you do for the Obama campaign?
I organize the lesbian, gay, bisexual and transgender community in conjunction with our field team. That means traveling the state, organizing at Pride festivals, reaching out, making sure they're talking to neighbors and friends and families. Some days it's reaching out to small businesses, making sure they're registering voters. Some days I'm in the office planning our next big move.
How did you get involved?
In 2008, I was a neighborhood team leader in the Clintonville area. After 2008, it was so important to me to do everything I can to ensure progress for LGBT Ohioans. We've seen so
much forward progress and it was so important that continues. If that meant taking time off school, or whatever that took, I needed to do it. Every day feels like a week sometimes, but it's great to get up every day and do this.
What is it like working in a swing state?
It's a lot of fun. I think a lot of folks will tell you this year it will come down to Ohio. Being able to work in a state that's going to decide an election, that's pretty exciting. And folks in Ohio know that.
What has President Obama done for the LGBT community?
He's done so much. Repealing don't ask don't tell is huge. No longer do Ohioans have to lie to support the country they love. And that speaks so much to his value of fairness and equality. He hosted the first youth bullying summit at the White House and attacked head on the issue of bullying that youth face every day. Those are some of the biggest things, but there are so many other accomplishments.
What do your parents think of you working for the campaign?
I think they're proud. They see the work that I do and they don't necessarily understand it all when I get home at 11:30 p.m. and reply to their email from two weeks ago, but I think they're proud.
Drew Stroemple was 8 when his teacher asked him to color either an elephant or a donkey for the coming elections. "I didn't know, but something about that elephant felt right," the Ohio State political science major says. Stroemple, 20, has worked on several campaigns, including interning for U.S. Rep. Jim Renacci, and is president of the Ohio State College Republicans.
What have you done to support Mitt Romney's campaign?
It's very grassroots focused. It's very powerful when you have a young person on your doorstep saying, "I care about the debt and the economy and I believe Gov. Romney is the candidate to change that." I've worked very hard to get young people to knock on doors and make calls and spread the message.
How did you get involved in political work?
I watched the 2008 election because I was in (advanced placement) government in high school at the time. I never thought about which party I aligned with. I was very impressed by Obama; he was a very aspiring figure. But I started to look at the issues and what I cared about, and that was when I started to find I didn't align with his views. Then after watching what the president did in his first two years in office, I thought it was not what the country needed. So in 2010, I finally decided to do something about it. I got involved with Rep. Jim Renacci in Northeast Ohio. I fell in love with politics.
Are young people engaged in politics?
We need to get more people engaged. I think we're starting to be successful. You can see the enthusiasm when students knock on doors, when they see Gov. Romney at a rally. If we could just get more kids at these events, we'll get more people engaged. It's slow, and it's a tough process.
What is it like working in a swing state?
I'm so fortunate to be, not just in Ohio, but in such an important county. Being in Columbus we have so many opportunities to be politically active. I tell the kids to take advantage of it because not everyone gets this chance.
Are your parents Republican?
Both my parents support Gov. Romney. My mom's not too political. She tells me, "I don't care if you're a Republican. Just don't be corrupt. Don't have an affair." My dad's more into politics. He's always forwarding me emails about what's going on. They've encouraged me and helped me out when I want to do volunteer work.
Sara Valentine doesn't sleep much these days. When the Ohio State junior isn't attending class, she's interning for Barack Obama's campaign, registering students as voters (her goal is 30 a day). The 20-year-old political science major is the president of Buckeyes for Obama and campaign coordinator for the Ohio State University Democrats.
How are you supporting President Obama's campaign?
We're having a huge voter registration initiative. We have a high goal and we're hitting that hard. We're trying to prove people wrong: We are not young apathetic voters. We care about this election.
Do you think young people are engaged enough in politics?
It depends on the issue. Every single person has an issue that is important to them, including me. The president has done so many great things for students. He doubled the Pell grant funding, and that affected me personally. My mom's a single parent. I don't have the luxury of asking her for $25,000 for school. The cost of college has gone up substantially, and any help I can get from the president is great.
What is your first political campaign memory?
I was in elementary school, and we had a makeshift election for the Bush/Kerry race. I remember being quite excited that Kerry had won in school, even if that wasn't the case in the real world. I remember being very excited about that. I love politics.
Is your family involved in politics?
There is no one in my family who is politically active. I got the bug pretty early. I like standing up for people who don't have a voice. I could go and make a difference in another job, but if they don't have the funding to continue with the program, they won't be able to make a difference.
How do you balance school and campaigning?
It's hard balancing so many things, but that's how I like it. I'm a fulltime student and work with the campaign. I can come out of class and help with registration. I can get people while they are getting dinner.
Do you have any political aspirations?
I have quite a few, but you know we'll see. I hope to run someday, when I get out of college. I'll probably go to law school. But whatever life brings, we'll see.


text:
Places Discussed (Cyclopedia of Literary Places)
Tavern. Unlicensed public house in the wild Mayo County region on the west coast of Ireland in which the play is centered. The location is somewhat north of John Millington Synge's beloved Aran Islands, and thus an apt setting in which to illustrate Synge's repulsion at the ignorance of Ireland's poor. Synge came by this disdain honestly, through his fiercely Protestant family, who owned land in both County Galway and County Wicklow (thereby bracketing the island both east and west).
Within the setting's isolation, there is community. The tavern stands alone but is constantly filled with people. These people have carved an existence out of their remote setting, relying on contact with the larger world both through the post and the gossip at social gatherings. Nevertheless, this is a place beset by evil, both real and imagined. There are strange people out at night, from the madmen of Keel to the ten tinkers in the glen to the thousand militiamen in the countryside. Even the unseen priest, Father Reilly, haunts the action. The people surrounding this public house threaten it with madness, theft, war, or religion. Into this place comes Christy, a boy from eastern Ireland, and therefore one possessing more native wit than the westerners he encounters. He brings the evil of the outer world with him but wins over the local folk. When the truth is found out, they turn against him savagely. However, after he is reprieved from a...
(The entire section is 281 words.)
Want to Read More?
Subscribe now to read the rest of this article. Plus get complete access to 30,000+ study guides!
Historical Context
Birth of the Irish Theater
At the end of the nineteenth century, Irish writers were divided between two impulses: to express the nostalgia of the heroic legends of the past and to illustrate the beliefs and struggle of the home-rule movement. They met in Dublin, as that city's theater became an artistic representation of Irish country life and legends as well as the politics of the age.
In the 1890s, the Irish middle and upper classes clamored for literature that reflected the nationalistic spirit of the age. They turned their interest to the tales of Ireland's heroic past, recorded by folklorists like Douglas Hyde who studied the Irish language still spoken by the inhabitants of the western coast of the island. William Butler Yeats who had already established himself as an important Irish poet, discovered the store of poetic material in the stories of this part of the country. Yeats, along with Lady Gregory and Edward Martyn, founded the influential Irish Literary Theatre in 1899 to promote a national movement of the arts. When Martyn, an Ibsen devotee, later left, the remaining members retitled themselves the Abbey Theatre Company. Yeats had envisioned a people's theater where writers and actors could return to the sources of their art: the native speech, habits, and rich mythology of the Irish. Later, Synge would become one of the Abbey's directors.
(The entire section is 607 words.)
Literary Style
Realism and Poetry
The play is an interesting mixture of realism and poetry. Synge' s time on the Aran Islands studying the inhabitants helped him create vivid and accurate portraits of Irish life. He writes in his preface to the play that his experiences on the islands provided him "more aid than any learning could have given [him].''
His focus in the play also reflects the dominant themes of realism, with its attention to ordinary people confronting difficult social problems. In The Playboy of the Western World, Synge adopts this focus in his depiction of the villagers' treatment of Christy, which is based on a combination of the community's devotion to mythmaking and its mob mentality.
The language of the play is a complex combination of realism and poetry. Dubliners were initially shocked by terms like "shift," referring to women's garments that they found filthy—terms that are considered examples of local color today. When this language is expressed through the unique phrasing and rhythms of the Irish tongue, Synge creates poetry within his prose. Christy's declarations of love to Pegeen are especially praised for their lyric beauty.
As an extension of the theme of mythmaking, Synge transforms Christy into a symbol of the Christ figure. His name adds just a y, and, like Christ, he is the son of Mahon (man). The villagers' treatment of him echoes Christ's, as...
(The entire section is 248 words.)
Compare and Contrast
Beginning of the 1900s: In the latter part of the nineteenth century, realism becomes the dominant literary movement in the Western world. In the last decade of the century, symbolism and naturalism emerge as important new movements.
Today: Musicals like The Producers and reality-based plays like Proof dominate Broadway.
Beginning of the 1900s: In 1905, Arthur Griffith founded Sinn Fein among Irish Catholics to help establish home rule in Ireland. Demonstrations, especially in Northern Ireland, often turned violent as England fought to retain control over her colony.
Today: The troubles in Ireland have calmed but have not been resolved. Northern Ireland is still under British rule and as a result, violent skirmishes between the Nationalists and those loyal to England still occur.
Beginning of the 1900s: Samuel Clemens dubbed this era "The Guilded Age,'' due in large part to the industrialization of the West. During this period, a handful of large industries gained control of the economy in the United States. Those industrialists who profited saw their fortunes grow at a rapid rate while the working class suffered with low wages and dangerous working conditions.
Today: Public awareness of major companies exploiting...
(The entire section is 214 words.)
Topics for Further Study
Research the movement for home rule in Ireland during the early part of the twentieth century. Explain how the clash between those loyal to England and those who supported Ireland's separation from the British is reflected in the themes of the play.
During the first few decades of the twentieth century, a ''New Woman'' emerged who rejected the stereotyped roles of the past and demanded equal rights. Investigate whether this movement also appeared in Ireland. Then, analyze Synge's treatment of women in the play. Do they fit stereotypes, or are they reflective of more modern ideas concerning a woman's place?
Read Synge's Riders to the Sea. Analyze the qualities of Irish life and character as depicted in the play and compare this portrait to that of The Playboy of the Western World.
Think about how an American version of the play would be produced. Would the play be able to retain its main themes, or would they have to be tailored to reflect the American character? Write up a scene-by-scene outline of a possible American version.
(The entire section is 176 words.)
Media Adaptations
Playboy of the Western World was adapted for television in 1946 by the BBC and in 1983 in Ireland.
A film version of Playboy of the Western World was produced in Ireland in 1962, starring Siobhan McKenna and Gary Raymond and directed by Brian Hurst.
(The entire section is 42 words.)
What Do I Read Next?
In The Abbey Theatre (1987), E. H. Mikhail presents a comprehensive history of The Abbey Theatre from the beginning to the present time, focusing on the actors, playwrights, directors, and supporters of the theater.
Following Yeats's suggestion, Synge lived for a time on The Aran Islands, where he made careful observations of the inhabitants there. He gathered together his notes in essay form, which were eventually published as The Aran Islands (1907).
Riders to the Sea was produced by the Irish National Theatre Society in Dublin in 1904. Like Playboy of the Western World, this play presents a realistic yet poetic vision of Irish life, specifically on one of The Aran Islands off the western coast of Ireland.
In the Shadow of the Glen (1903) was Synge's first play to be produced by the Irish National Theatre Society in Dublin in 1904. It began the author's battle with Irish theater patrons over his authentic portrait of Irish life.
(The entire section is 153 words.)
Bibliography and Further Reading
Bennett, Charles A., ''The Plays of J. M. Synge,'' in the Yale Review, January 1912.
Corkery, Daniel, Synge and Anglo-Irish Literature, Mercier, 1931.
Coxhead, Elizabeth, ''J. M. Synge / Lady Augusta Gregory,'' in British Writers, Vol. 6, 1983, pp. 307-18.
Howe, P. P., J. M. Synge: A Critical Study, Martin Secker, 1912.
Podhoretz, Norman, ''Synge's Playboy: Morality and the Hero,'' in Twentieth Century Interpretations of "The Playboy of the Western World'': A Collection of Critical Essays, Prentice-Hall, 1969.
Review of The Playboy of the Western World, in Freeman's Journal, January 28, 1907.
Review of The Playboy of the Western World, in Irish Times, January 28, 1907.
Bushrui, S. B., ed., Sunshine and the Moon's Delight, Colin Smythe, 1972.
Bushrui edits several essays on Synge's plays, including several on his use of language.
Greene, David H., and Edward M. Stephens, J. M. Synge, 1871-1909, rev. ed., Macmillan, 1989.
This indispensable biography contains little criticism of the works, but it offers a wealth of information about Synge's life and influences on his work.
Price, Alan, Synge and Anglo-Irish Drama, Methuen, 1961.
Price presents insightful...
(The entire section is 207 words.)
Bibliography (Cyclopedia of Literary Characters, Revised Third Edition)
Bloom, Harold, ed. Modern Critical Interpretations: John Millington Synge's "The Playboy of the Western World." New York: Chelsea House, 1988. Eight representative essays consider Christopher's self-transformation and parallels with Christ, the realistic and fantastic aspects of the play, its complexity and ambiguity, and its irony, wit, and poetry.
Greene, David, and Edward M. Stephens. J. M. Synge: 1871-1909. Rev. ed. New York: Macmillan, 1989. The standard, authorized biography based on Synge's diaries, letters, and manuscripts. Provides the basic accounts of the composition of The Playboy of the Western World and of its riotous reception in 1907.
Kopper, Edward A., Jr., ed. A. J. M. Synge Literary Companion. Westport, Conn.: Greenwood Press, 1988. A valuable collection of sixteen chapters by leading scholars, covering all aspects of Synge's life and work. Excellent introduction to the critical literature. Good bibliographies.
Owens, Cóilín, and Joan Radner, eds. Irish Drama: 1900-1980. Washington, D.C.: Catholic University of America Press, 1990. Places the play in the general context of the Irish dramatic movement. Concise introduction, map, and the best detailed annotations to the text of the play.
Whitaker, Thomas R., ed. Twentieth Century...
(The entire section is 242 words.)
Source: Drama for Students, ©2013 Gale Cengage. All Rights Reserved. Full copyright.
Source: Cyclopedia of Literary Places, ©2003 Salem Press, Inc.. All Rights Reserved.
Source: Cyclopedia of Literary Characters, Revised Third Edition, ©1998 Salem Press, Inc.. All Rights Reserved.


text:
By the Numbers
These days we're almost saturated with incredibly detailed images from the Mars surface. Back in the early days of astronomy via spacecraft, scientists studying the red planet had to wait for data that was then converted into a digital image. In this 1965 image, an impatient astronomer took the strips printed with numbers from the "real-time data translator" and colored them in himself, revealing the geography of the Martian surface. Image via @ridingwithrobots
Image: NASA


text:
Hang tight!
Recipe by angeleyes173
"This sauce recipe has been handed down from generation to generation. It's a family favorite and left-over sauce freezes well. Best when cooked all day in a slow cooker. Since there is no added oil this sauce is fat free."
Watch video tips and tricks
5 (29 ounce) cans tomato sauce
3 (6 ounce) cans tomato paste
3 cloves garlic, minced
1 onion, chopped
3 tablespoons dried rosemary
3 tablespoons dried oregano
3 tablespoons dried thyme
3 tablespoons dried parsley
1 bay leaf
1 pinch crushed red pepper flakes
We really liked this sauce! Scaled the dried seasonings down a bit since I am sure the author meant teaspoons instead of tablespoons. Found many of the other reviews to be cruel and out of line so I decided to give this recipe a try regardless of some of the mean spirited reviews.
If I could have put anything lower than 1 star...that would have been more than this recipe deserved. I cannot believe I actually read this recipe and decided to make it because I wanted to do something easy in a slow cooker. This person must have been on some type of hallucination medication...and you know what I am talking about! This was the worst sauce I have ever tasted. Thank goodness I had a jar of Classico sauce in my pantry to save my family for dinner that night. I am warning you....never use this recipe. It is not edible. It's not fit for the bugs that live under my house to eat!! Please...for God's sake....do not make this sauce!!!!!!!!!!!!!!!!!!
65 Ratings
I made this again using only 1 tablespoon of the spices, replaced thyme with basil, and then added about 1 tablespoon of brown sugar and it was much more to our liking.
This sauce is really good. I didn't have a crockpot big enough so I used my Nesco oven and set the temp at 250 degrees and cooked it for about 6 1/2 hours. I then put the sauce in canning jars and processed it for 35 min. I'm looking forward to trying the sauce on pasta!
Yuck! I always try to find one positive because some people cannot take criticism well, and I usually find ONE good thing about a recipe. The only GOOD thing about this AWFUL sauce is that my crock pot is finally rid of it. I cannot believe this is a recipe that's been passed on for generations! The spices are so overwhelming and do not blend kindly. This was awful--one spoonfulwas all it took to realize that we weren't having it for dinner that night--or EVER AGAIN!
You do not have do be a semi competent cook to realize that this is a flawed recipe!! shame on you people for even wasting time and ingredients.......
I will not make this again. The slow cooker/crock pot tends to really bring out the taste of dried herbs--it magnified it so that the herbs were overwhelming. We couldn't even eat this. Sorry!
This basic spaghetti sauce is a great starting place for someone that isn't sure how to make in the slow cooker. I was surprised at how much flavor the extra spices added. I would not have normally used that much. I did add a little bit of sugar as well since I found the sauce a little bitter.
* Percent Daily Values are based on a 2,000 calorie diet.
Slow Cooker Spaghetti Sauce I
Serving Size: 1/10 of a recipe Servings Per Recipe: 10 Amount Per Serving Calories: 157 Calories from Fat: 13
Get the season's best recipes for holiday feasting.
Holiday cookies, cakes, pies, and breads. Get recipes and inspiration.
Get time-saving recipes to save your busy life.
See how to make a thick, rich tomato sauce that's just a bit spicy.
See how to make a traditional Mexican posole in your slow cooker.
This classic tomato pasta sauce with meatballs is easy and delicious.


text:
Rewards Card Gift Cards Kids Nature Thing What's Going On Parks Magazine
Make Reservations Check Rates Check Availability Camping Info Cottages Info Getaway Rentals Info Lodge & Conference Centers Info
Find a Park Rewards Card For Kids - Park Pals General Safety Tips Accessible Facilities FAQs Bring Your Pet Order Brochures About Us Support Your Parks Canal Lands Program Nature Preserves Ohio Trails Program Other Resources
Mailing Address: Ohio State Parks 2045 Morse Rd, C-3 Columbus, OH 43229-6693
Email us
The Ohio Parks and Recreation Council
The Ohio Parks and Recreation Council consists of a seven member board appointed to advise and make recommendations to the chief of the Division of Parks and Recreation in the areas of development, formulation and creation of policies, planning, programming, financing, and park acquisitions.
The council members are appointed by the Governor with one member representing each of the following areas: municipal parks, metropolitan park districts, conservancy districts, soil and water conservation districts, private recreational facilities; and two members are representatives of the general public. Each term of office is three years.


text:
Search for any place in the USA:
Overview, People, Health, Economy, Housing, Rankings, Climate Crime, Comments, Transportation, Cost of Living, Religion, Voting
Hesston (zip 67062), KS, gets 32 inches of rain per year. The US average is 37. Snowfall is 13 inches. The average US city gets 25 inches of snow per year. The number of days with any measurable precipitation is 78.
On average, there are 225 sunny days per year in Hesston (zip 67062), KS. The July high is around 93 degrees. The January low is 20. Our comfort index, which is based on humidity during the hot months, is a 30 out of 100, where higher is more comfortable. The US average on the comfort index is 44.
We're looking for comments about Hesston. Express your opinion


text:
27" Front-Load Steam Washer with 4.1 cu. ft. Capacity, 10 Cycles, 6 Hour TumbleFresh Option, Sanitize Cycle with Steam, Eco Monitor and Energy Star Qualified
Our Price
After Savings
27" Front-Load Washer with 4.3 cu. ft. Capacity, 12 Cycles, EcoBoost Option, NSF Certified Sanitize Option, Allergen Cycle, Precision Dispense and Quiet Spin 360 Technology
4.3 cu. ft. Front Load Washer with 12 Wash Cycles, 5 Temperature Settings, Precision Dispense Ultra and Energy Star
4.3 cu. ft. Front Load Washer with 12 Wash Cycles, 5 Temperature Settings, Precision Dispense and Energy Star
28" Top-Load Washer with 4.8 cu. ft. Capacity, 13 Wash Cycles, 4 Temperature Settings, Care Control Temperature Management and Stainless Steel Wash Basket
27" Front Load Steam Washer with 4.3 cu. ft. Capacity, 26 Wash Cycles, 6th Sense Live Technology, NSF Certified Sanitize Temperature, Stain Assist and Energy Star Qualified
© 2013, AJ Madison Inc. or its affiliates


text:
I love "Cup and Handle" formations! Reading Charts is much better than reading about the Company!
stagg, I agree with you completely (and so does the market today...up $0.48) I also have made great profits stepping in and out of this stock and collected many nice dividends.
Management is STINKING up the entire Northeast with their LIES!
This is not the first time Nawar has suddenly sold all his shares and moved on. He wrote many articles for SA on Gasfrac with the latest being Apr. 22, 2012. and was long the stock. Without warning he dumped all his Gasfrac shares and was long EQU with his first article about EQU appeared on May 3rd.
I'm not saying he didn't help EQU investors, but he sure hurt his followers on GSFVF!.
Sentiment: Strong Buy
This stock is bleeding me badly. I should have taken my huge paper losses at $7.
This Company can't get out of it's RUT!
Why can't traders tell the truth on these boards?
PS: Even 1,000 shares is questionable...this stock has plenty of air still in it.
Has the TIDE running where you are? Is it going out?
staggman, thank you again for great "on-the-ground" (or should I say "under"?) information. Your comments always contain interesting opinions and news.
Although I don't own ARLP right now (I took profits too soon earlier this year after loading up in the mid $50s,) I have my eye on a re-entry point.
Sentiment: Strong Buy
I gonna lose again on this POS!
Depends WHY it was halted!
He may be from NJ where Corzine and the Leaders before hin stole from the taxpayers.
Or Chicago and other democratic regions where the dead still vote.
It's number one because they tell the TRUTH!
The other networks SPIN the News to their own Liberal slant...to the point of LYING...CBS,etc
and it's tanking again today.#$%$!
Same here. I bought 500 shares in low to mid 50s. Sold when it stalled in mid $60s and had some drops so I sold.....it went right to $77 plus!
It has been one of my favorites for years...but price action is NUTS
Just bought more at $3.64
Not really, although it was SLASHED early 2013. Their income fluctuates because Management doesn't understand its own biz.lies
Most of these spammers are promoting a "PAID" stock newsletter and they have multiple names. I don't think YHOO banns their IP so they just keep using different names. I feel sorry for someone that has to resort to such a crummy job in order to live.
My handle fell off.
What does thet mean?
Shall I look for a head & sholders?
That reminds me, time for a shower.


text:
Nurturing Youth through Community, Education, and Parenting Conference
Brought to you by Gunnison-Hinsdale Early Childhood Council
When |
Nov 09, 2012 04:00 PM
to Nov 10, 2012 04:30 PM |
Where | University Center |
Contact Name | Lealyn Poponi |
Add event to calendar |
vCal iCal |
Target audience: Students, Parents and Professionals working with youth 0-18
Full conference fee: $40, WSCU student price: $15, just Friday: $15, just Saturday: $25.
For full or half day conference participants: Pizza and refreshments provided on Friday. Snacks, refreshments and a Rare Air Cafe lunch ticket are provided on Saturday.
Registration available online.


text:
Back in the day it was an odd pairing referred to as a "May/December" romance meaning the younger person in the relationship was May (usually the younger woman) and December was the older man.
Of course things have changed and now it's commonplace to see relationships like this. Research shows that the average age difference in most relationships where the guy is older, is 4 years and 7 months. Then there's the formula that I've always heard that a man can't be in a relationship with a younger woman unless she passes this test: She can't be younger than 1/2 his age + 7 years.
Ex: a 50 year old man shouldn't be in a relationship with a woman younger than 32.
TOPIC OF THE DAY: "What's your opinion on age difference in relationships? Regardless of who's the older partner, at what number of years does it become just a little "creepy"?
Join the conversation NOW on our Facebook page.


text:
Many times I purchase items from a thrift store or yard sale. If I find things I want or need, it's a way for these used items to be recycled & continue in use.
I think it's important to exchange energy consciously and intentionally, and money is one powerful form of energy, it is currency after all. I always try my best to consider what my exchange is for anothers work. I don't download songs without paying for them, burn movies, download e-books, etc., unless they are offered by the author / producer or they are old enough to have enjoyed their fair share of payment for the work that has gone into them. I do borrow from the library, as part of a public service of education though, and when a book is useful, I often buy it as a form of repayment, but also, I often am late returning my books so give a fair bit of money to the library. I do consider it to be very important to give for what I receive.
In consideration of books or music for example, I consider the work others have done on a new book for readers to enjoy and gain benefit from. Although I could easily download a song online for free, I choose not to, but rather purchase the work. For a book it is much the same. I personally feel it is important to have a fair exchange of energy for the work an author has put into compiling, researching and writing the book along with all the other work that goes into creating a book, publishing it, etc., which assists and employs a fair number of people and effects many lives through families of those employed, etc.
I first came across the concept of money being considered in this fair and respectful manner when reading a book about druidry called "Walking the Mist" and it resonated as a great truth to me. Before this I still had firm beliefs in not stealing, etc., but hadn't considered so much my ability to affect the world through how I choose to direct my money.
Rather than buying from large chain stores that sell numerous products that are considered to be against my values, such as environmentally unfriendly chemical products, or child labour in third world countries, I choose to support smaller companies, and local companies that are more about providing specialized services and products that are guided by a passion for sharing what they have to offer rather than huge profit margins.
Money is energy, and through my choices, I, although in a small, yet impactful way, have the power to affect the lives of others and put my money towards things that I believe affect others in a positive way. Being guided by ideals of good ethics, and learning and making the best possible choice for the knowledge I have, gives me the opportunity to use this energy we call money to be a creative force for my own personal vision.
In terms of the law of attraction as well, I think it is always important to consider what giving does for the other, instead of always for the self and how it influences the results of others lives.
The Meaning of Life is to Eat the Apple - Me
Wisdom comes from asking questions
Nothing really matters, love is all we need. - Madonna
I predict the weather will be unpredictable this year - Sylvia Browne
An eye for an eye only ends up making the whole world blind - Gandhi
If it doesn't make sense, it's usually not true. - Judge Judy
Many times I purchase items from a thrift store or yard sale. If I find things I want or need, it's a way for these used items to be recycled & continue in use.
A little of my view on conglomerates...
Unfortunately, with huge conglomerates selling products with such small mark ups this means that there is essentially no competition, and nobody bothers with supporting the little guys out there. It's a vicious cycle because the little guys out there have to charge a bit more because most people are buying from the conglomerates who offer very low prices. Since there are less customers going to the "mom & pops shop" - mom & pop aren't making enough money to make ends meet so they need to charge more for each item, hoping to make enough money to stay in business.
It looks like our only options will be - Amazon, Yahoo, Google, Microsoft, Ebay... Maybe they'll all be bought up by each other or Walmart and become the "One Company" one day and we'll all have to work for them - not surprisingly they are at the top of the list for difficulty in learning how to contact customer support through their own sites. Thank goodness this site was born.
Please excuse my mini-rant on conglomerates.
The Meaning of Life is to Eat the Apple - Me
Wisdom comes from asking questions
Nothing really matters, love is all we need. - Madonna
I predict the weather will be unpredictable this year - Sylvia Browne
An eye for an eye only ends up making the whole world blind - Gandhi
If it doesn't make sense, it's usually not true. - Judge Judy
While being apart of the monetary system of today, I do agree with you, Celtaur. But for some reason, I just don't like money. I feel like everyone, even the small companies, put it's value before the value of human beings. I don't like the whole monetary system in general. Yes, I know, currently that we need it and what not(for now), but I honestly believe there is an alternative way to living and being happy without it completely. I just personally feel that spirituality and money do not mix. Have any of you ever heard of the idea of a resource based economy and "The Venus Project"? I'd love to know your thoughts on it.
Never mind my last reply, I couldn't figure out how to delete it,, I just read your reply to The Venus Project in the zeitgeist thread, Celtaur.
To a limited extent, I agree with you Sylus. Money kind of sucks, in a way.
Nobody can fully dispute the value of the money system, especially now that it is so deeply entrenched all over the world. (I for one would really hate to try to learn the art of bartering at this late stage...) However I have never been what you'd call a "money-motivated" person and I tend to shy away from those who love it too much. I acknowledge fully that I need it to provide for my family and to have the earthly things in life we want to have. However, I do the things I do more for the difference I can make or for personal development rather than a desire to hoard individual wealth. So when I spend money, I take more consciousness of the act than some. When I buy music, artwork, literature, etc. I'm making a statement of support rather than blindly accumulating more stuff to clutter up our spare bedroom. If something seems 'neat' but not worth moving from place to place, I leave it on the shelf at the store. And I take great joy in purging myself of possessions that I no longer have a need for. Call me crazy, but I've always been somewhat baffled by the "whoever dies with the most stuff, wins" mentality shared by many of my fellow human beings.
"It is not the accumulation of extraneous knowledge, but the realization of the self within, that constitutes true progress." - Okakura Kakuzo
For days now I've been thinking about this very subject. With the economy changing the way it is, I think its on many peoples minds. The system built around money is not effective.
For me, I've been thinking about capitalism as an imperfect system. I see that it does have the benefit of allowing people to make choices and is a motivating factor for people to actually work and not sit around, but there is flaws in the purpose of this. Many work at jobs they don't love because they have to, and often compromise their health, well being and quality of life. Capitalism, I think, works off the premise of survival - so in that sense it is a very low form of existence. In this sense it keeps people in survival mode, always needing more to try to get away from the mere experience of just survival, with the hopes of more. In survival mode, the ego grows, the divisiveness, the competition. By nature of the system of capitalism people are lead into a dog-eat-dog competitive reality, which can, and often does, turn quite ugly. People will do a lot of things that may compromise personal integrity and ethics just to get ahead, to be the one on top, and have the inflated ego.
From the perspective that this competition is desirable as a positive role, we can see that leads to the development and advancement of new circumstances, new ideas, new technology etc. But then again, looking at the flip side we can see that it also hinders advancement of new ideas - for example large oil companies hold new technologies down because they have the power (they've reached the top of the capitalist chain). How does one reach the top... well, with competition being the name of the game, it can pretty much be guaranteed that some ethics have been left behind while climbing to the top, fighting off all those other competitors, getting the upper hand in any way possible.
So with this said - from being in survival mode, to ego, to diminished ethics, to beating out the competitor, is this what people are working so hard for? To slowly work their way through this system for the payoff of materialism, a payoff that ultimately goes unsatisfied because the ego always wants more. In general, considering we are built for survival, our very bodies require us to do what it can to survive, are we destined to live in a world where competition is glorified and desired?
I think it is quite sad that we see on television so many people gloating over what they have, so many singers lyrics about how great they are, how much more they have than someone else - essentially egoic and in my opinion quite unconscious - It's kind of like they are numb in a sense. When I saw that Mariah Carey had a ring for 2.5 million dollars and she was flaunting it and showing it off for the camera's like it was a highlight of importance in life, I wondered how unconscious she really was/is, or how desperate she was to prove herself to the world... then I guess I feel sorry for her, as there must be some deep hurt, suffering, going on in there that she's compensating for. I certainly didn't think it was commendable, nor desirable. I just thought of how much good could be done with that money, but that she (and her husband who gave it to her), chose to put that energy towards their ego.
The cause of suffering is desire.
The Meaning of Life is to Eat the Apple - Me
Wisdom comes from asking questions
Nothing really matters, love is all we need. - Madonna
I predict the weather will be unpredictable this year - Sylvia Browne
An eye for an eye only ends up making the whole world blind - Gandhi
If it doesn't make sense, it's usually not true. - Judge Judy
The way I see it, the only reward for making a life's goal out of chasing wealth is various flavors of disappointment. If you don't get all that you want, you just keep coveting more and feeling bad about what you don't have. If you succeed at becoming fabulously rich, you are likely to be envied, begged from by hangers-on, resented, lonely, overworked, and/or unable to identify with the 'regular Joes' around you. Sure, maybe the hollow masses will idolize you for your excessive lifestyle. But really, what's another person's syncophantic envy worth in eternity? I think the world would be a better place if more people remembered the virtue inherent in things like moderation, humility, service, and contentment.
"It is not the accumulation of extraneous knowledge, but the realization of the self within, that constitutes true progress." - Okakura Kakuzo
I own nothing except my books, a portion of the furniture and my clothes. I have no money. All I earn, from working full time, painting and writing, goes into feeding and clothing, the family heating the house and paying the bills. I share the use of my partner's car these days. I admit, the odd luxury would be nice.. a holiday more than every quarter century, my own car again, for instance! But why should I need more?
"Ah, Love, Could thou and I conspire, To grasp this sorry scheme of things entire, Would we not shatter it to bits, And then rebuild it nearer to the hearts desire?"
Omar Khyyaam of Naishapur
There are currently 1 users browsing this thread. (0 members and 1 guests)