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SOURCE: Grand Rounds Presentation, UTMB, Dept. of Otolaryngology
DATE: October 13, 1999
RESIDENT PHYSICIAN: Michael Prater, M.D.
FACULTY PHYSICIAN: Shawn Newlands, M.D.
SERIES EDITOR: Francis B. Quinn, Jr., M.D.
|Return to Grand Rounds Index|
Genetics is a diverse subject concerned with variation in living organisms. Medical genetics is concerned with human genetic variation of medical significance, and one of the foremost aims of medical genetics is to understand the basis for mutations and genetic disease and to use that information to improve treatment. Within medical genetics there are numerous areas of interest, each of which is progressing rapidly. Major areas of specialization include, but are by no means limited to:
History of Medical Genetics
Genetics in medicine did not always occupy such a place of prominence. Although now fully recognized, prior to Mendels principles of heredity in 1865, inheritance was considered an insignificant part of the life process. Mendels laws went unappreciated and unrecognized until rediscovered in the early twentieth century. Mendel himself became disillusioned and abandoned experimental research.
Charles Darwins the Origin of Species emphasized the hereditary nature of evolution, but at that time (1859), heredity was believed to be environmentally acquired (see Jean Baptiste Lamarck). The next "pioneers" of medical genetics did not occur until the early 1900s, when Francis Galton (Charles Darwins cousin!) and Archibald Garrod recognized the works of Mendel and postulated evolution occurs via "nature versus nurture" and that "inborn errors of metabolism" lead to biological abnormalities.
Little progress was made until 1953 when James Watson and Francis Crick described the molecular basis of DNA. They were awarded the Nobel Prize in 1962.
In 1990 the "Human Genome Project" was started, with the goal of identifying every human gene by the year 2005. Of note, as of October, 1999, they were 9% completed.
Classification of Genetic Disorders
Genetic disorders may be classified into one of three types: single gene disorders, chromosome disorders and multifactorial disorders. Although virtually all disease progresses as a combination of environment and genetics ("nature versus nurture"), the genetic contribution is now believed to play the most significant role.
Single gene defects are caused by mutant genes, usually a single critical error in the genetic code. Such disorders are usually phenotypically obvious, and include neurofibromatosis types I and II, osteogenesis imperfecta and cystic fibrosis. More than 4000 single gene disorders have been described.
Chromosome disorders are not due to a single genetic mistake but are due to an excess or deficiency in the number of genes contained within an entire chromosome. The most common example is Down Syndrome (Trisomy 21), which is an extra normal copy of chromosome 21. Other examples include Trisomy 13, Turner syndrome and Klinefelter syndrome. These disorders are usually fatal in utero, and are believed to account for more than half of all spontaneous abortions.
Multifactorial inheritance is respoonsible for a wide range of disorders. Unlike single gene disorders or chromosome disorders, these disorders are believed due to multiple single genetic mistakes which result in a characteristic pattern. Common anomalies in cleft lip and palate and neural tube defects. Clinical diseases are also represented in this group, and include some forms of cancer, coronary artery disease and diabetes mellitus.
Chromosome Structure and Function
The human genome contains approximately 7 billion base pairs of DNA organized into 23 pairs of chromosomes. By current estimates, these base pairs code 100,000 genes and proteins, which control all aspects of life.
DNA itself is a polymeric nucleic acid composed of three subunits: a five carbon sugar (deoxyribose ribose in RNA), a nitrogen base and a phosphate group. The base pairs are purines and pyrimidines and include adenine, guanine, thymine and cytosine. The base pairs are connected by phophodiester bonds in the 53 direction. Each single strand is connected via hydrogen bonds to a complementary strand in the 35 direction. In the intact human chromosome, these nucleotide chains may stretch millions of nucleotides long.
Although genetic information is contained within DNA, RNA is required for the synthesis of proteins. DNA is used as a template for RNA and proteins are translated from the RNA. This is known as the "central dogma" of molecular biology.
Tools of Molecular Genetics
The tools of molecular genetics have undergone revolutionary changes since the late 1970s, and include the identification and use of restriction enzymes, cloning for recombinant DNA, vectors, probes, polymerase chain reaction, DNA sequence analysis and protein analysis.
Molecular cloning requires the use of restriction endonucleases to cleave a DNA strand at a specific site. For example, EcoRI cleaves DNA at a palindromic site on each DNA strand. There are hundreds of restriction endonucleases able to form countless DNA fragments. The specific DNA fragments are then combined with a known DNA strand, usually from a bacterium, using DNA ligase. The combined fragment is then inserted into a rapidly dividing bacterium, which are placed in culture medium to form large amounts of the desired "recombinant" DNA. A vector is DNA that can use the host bacterium (or yeast, or virus) to autonomously replicate. This allows a virtually endless supply of the recombinant DNA fragment.
Once a specific recombinant DNA strand has been isolated, the structure of the fragment is determined using Southern Blotting. Southern Blotting involves electrophoresis of the recombinant DNA followed by hybridization with known radioactive phosphorylated DNA fragment. Northern blotting is the corresponding method of isolated RNA fragments.
Of all the techniques available for the analysis of DNA and RNA, polymerase chain reaction (PCR) is the simplest, most rapid and most effective. It is based on the enzymatic amplification of a sequence of an unknown DNA fragment. The DNA fragment is formed by the action of DNA polymerase on a "primer" strand of DNA. The primer strand is a portion of the unknown DNA which is paired with a known fragment of a short oligonucleotide. The procedure is rapidly repeated. After 30 rounds of amplification, more than a billion DNA copies may be formed.
Once the recombinant DNA is isolated, DNA sequence analysis may be performed. The most common method is the Sanger procedure, named after Fred Sanger, who was awarded the Nobel Prize for his work in 1980 (his second, his first was in 1958 for protein sequence analysis). The method involves using a nucleotide analog during DNA synthesis which inhibits DNA polymerase. Electrophoresis is then used to determine fragment size. Depending upon the nucleotide analog, the sequential identification of each DNA fragment may be determined.
Detection of specific proteins is usually performed via Western Blot Analysis. This technique is similar to the Southern and Northern Blotting techniques used in DNA and RNA analysis. It involves the detection of specific protein extracts which are obtained via electrophoresis. Chromotography separates the proteins based upon size. A known antibody is washed over the protein. The antibody may be radioactive or fluorescent for identification.
Genetic Variation and Mutation
A mutation is defined as any permanent change in the nucleotide sequence of DNA. They may be classified into three broad categories: genome mutations, chromosome mutations and gene mutation.
Mutations may occur in somatic or germline cells, but only germline mutations are inherited. Somatic mutations, however, are responsible for many medical problems, including a significant proportion of cancers, and perhaps, coronary artery disease. It is this reason that cancer and coronary artery disease are often considered "genetic" diseases.
Genome mutations are missegregation of the chromosome and usually result in aneuploidy. The classic example is Down Syndrome (Trisomy 21). These are the most common of all human mutations, and occur an estimated one per 50 meiotic divisions. Most of these mutations are incompatible with life.
Chromosome mutations are the next most common cause of genetic variation and mutation. They usually involve chromosomal translocations and rearrangement, and occur approximately once per 1000 meiotic divisions. These anomalies are usually incompatible with life.
Gene mutations are base pair substitutions, insertions or deletions in the DNA sequence. DNA replication progresses at a rate of nearly 20 base pairs per second per site of DNA polymerase. Despite this rapid speed, there is only one point mutation per ten million copied base pairs. Additionally, there are numerous "repair" enzymes which scan the "size" of the double helix and repair identified abnormalities. These repair enzymes are effective 99.9% of the time. Thus, an point mutation occurs less than one in 10 billion base pairs. Since there are approximately one billion base pairs, this translates to less than one base pair point mutation per cell division.
Genetics and Cancer
The field of cancer genetics is rapidly growing. Currently it is believed a tumor is a clone of cells derived from a single somatic mutation. These mutations are either single point mutations, multiple point mutations or translocations. The genes that cause these cancers are of two types: oncogenes and tumor suppressor genes. Oncognees facilitate malignant transformation whereas tumor suppressor genes block tumor growth.
Oncogenes are genes that affect normal cell growth. They are believed to be derived from normal growth genes, called protooncogenes, which have undergone a somatic mutation. This can lead to uncontrolled cell growth. Oncogenes have been identified by recombinant DNA techniques. Suspected oncogenes have been isolated and transferred into mice, thus generating malignant foci. To date, more than 50 oncogenes have been identified.
Tumor suppressor genes are responsible for blocking abnormal growth. Function of these genes are lost only when both alleles undergo a somatic mutation. This is more commonly known as the "two hit hypothesis" of cancer. In contadistinction, oncogenes are formed when only one allele of a protooncogene is altered.
P53 Tumor Suppressor Gene. The p53 tumor suppressor gene arrests the cell cycle in the G1 (growth 1) phase thus allowing repair of genetic injury. It also induces apoptosis (programmed cell death). It is the most commonly demonstrated abnormality in head and neck cancer.
Somatic mutation of the p53 tumor suppressor gene is postulated to induce SCC of the head and neck. Cigarettes and alcohol are known to cause mutations in this gene. In a study by Davidson in 1993, mutations of the p53 gene were found in 40% of head and neck cancer. Despite these findings, mutations in the p53 gene have not been conclusively shown to have prognostic abilities in SCC of the head and neck.
Bcl-2 Tumor Suppressor Gene. The normal B-cell lymphoma/leukemia 2 gene (Bcl-2) tumor suppressor gene functions to prevent apoptosis (programmed cell death). Studies by Friedman have identified this gene as a highly sensitive marker for predicting prognosis in squamous cell carcinoma of the head and neck. Friedman did a retrospective study of early (T1N0, T2N0) SCC of the head and neck and found overexpression of Bcl-2 correlated with a 50% cure rate versus a 90% cure rate in those with normal gene expression. Other studies, however, particularly those by Gallo, have failed to confirm these findings.
The Treatment of Genetic Disease
Genetic disease can be treated at many levels. Most diseases are treated at the "phenotypic" level by medical or surgical intervention.
Gene transfer therapy is the attempted modification of abnormal cell function by "transferring" normal functioning genes into the genome. An area of intense research at present, the goal is to transfer functional copies of DNA into a patient, leading to permanent correction of the mutant phenotype. There are two types of gene transfer therapy: gene addition and gene replacement. In general gene addition is more practical, as it is the expression of a normal allele that is required. Gene replacement, in contrast, has never been accomplished in vivo.
The goal of gene therapy is the improvement of a patients health by correction of the mutant phenotype. This requires delivery of the recombinant gene into the malfunctioning somatic cells. General transfer strategies include either gene transfer via a plasmid (usually through a bacterium), or more commonly, through a retroviral vector. Viral vectors use recombinant RNA and reverse transcriptase to function. It is therefore not necessary to transfer the recombinant nucleotide directly into the host genome.
Current problems in gene transfer therapy are primarily the inability to maintain a high expression of the transferred gene in the target cell. Conversely, the second most common problem is overexpression of the transferred gene in the target cell. These seemingly opposite problems are areas of intense research.
Genetic Disease in Otolaryngology
Cystic Fibrosis. Cystic fibrosis is the most common fatal autosomal disease in caucasians. The basic phenotypic defect is a failure of exocrine function, including those of the upper and lower airway as well as the pancreas. The CF gene has been isolated to chromosome 7q and spans about 250,000 bases. Recent studies have shown the defect probably involves failure of cyclic AMP activated chloride channels, which also leads to membrane sodium transport discrepancies. The first CF mutation is a deletion of phenylalanine at position 508, but this is found in only 70% of all people. The remainder are believed to suffer other point and/or frameshift mutations.
Current CF therapy is unfortunately limited to phenotypic medical and surgical therapy. Current areas of research include gene transfer therapy.
Cleft Lip and Palate. Cleft lip with or without cleft palate is one of the most common congenital malformations. Cleft lip with cleft palate (CL and P) is distinct from isloated cleft palate. They originate as a failure of fusion of the frontal process with the maxillary process at about 35 days gestation.
Although classically presented as a multifactorial disease, there are single gene forms, chromosomal disorders (particularly Trisomy 13) and teratogenic forms (Rubella, thalidomide exposure). The multifactorial nature of the disease is represented by the unusual inheritance pattern.
Human Papilloma Virus. The exact role of HPV in head and neck cancer is not yet known, although it is well documented to be carcinogenic to the genitourinary tract. It has also been shown that binding of the E6 HPV protein to the p53 tumor suppressor gene leads to markedly decreased p53 action and subsequently tumorgenesis in vitro.
HPV oncogenic types 16, 18 and 31 have been associated with squamous cell carcinoma of the tongue, tonsil, larynx and pharynx in 46% of post mortem specimens. There was no statistical correlation towards survival in these specimens.
Thyroid Carcinoma. Medullary thyroid carcinoma (MTC) is a neoplasm of the parafollicular C cells of the thyroid gland. They are derived from the ultimobranchial body and secrete calcitonin. Two types exist, the sporadic and the familial forms. The familiar forms are hereditary and are seen in the MEN II syndromes. MEN IIA involves pheochromocytoma and hyperparathyroidism, whereas MEN IIB is associated with neurofibromatosis and Marfans habitus.
Familiar MTC is associated with the a mutation in the RET protooncogene. More than 90% of all people with this protooncogene develop MTC. The RET protooncogene is located on the short arm of chromosome 10.
Papillary thyroid carcinoma is also associated with genetic abnormalities, with more aggressive lesions associated with aneuploidy. Noninvasive disease is uniformly diploid.
Salivary Gland Neoplasms. Prognostic significance has long been associated with genetic markers in salivary gland tumors. Adenoid cystic carcinoma was studied in a series of twenty patients. All patients with DNA aneuploidy recurred after resection, whereas only 2 of 14 DNA diploid lesions recurred. Of note, aneuploid lesions are usually more radiosensitive. Similarly, salivary gland adenocarcinoma neoplasms which showed expression of c-erb B2 oncogene were more difficult to resect, recurred more frequently and had more frequent nodal metastases.
Acoustic Neuroma. Approximately 5% of all acoustic neuromas are familial, and are associated with neurofibromatosis Type II. The chromosome has been shown to be a deletion of the short arm of chromosome 22.
Congenital Hearing Loss. Approximately 60% of all congenital hearing loss is associated with a genetic and/or phenotypical abnormality. Recently, several chromosomal abnormalities have been identified.
Waardenbergs Syndrome is an autosomal dominant disorder with variable penetrance. Clinical manifestations include dystopia canthorum, hyperchromatic iris, white forelock and sensorneural hearing loss. The genetic locus has been identified and named the PAX3 locus of chromosome 2. Currently, all therapy is at the phenotypic level.
Ushers Syndrome is an autosomal recessive disorder associated with retinitis pigmentosum. It exists in five different classifications, all of which have been isolated on different chromosomes. All therapy is currently at the phenotypic level.
Pendreds Syndrome is an autosomal recessive disorder with variable penetrance that has recently been mapped to the long arm of chromosome 7. It is associated with thyroid goiter and thyroid carcinoma. Treatment is currently at the phenotypic level.
Alports Syndrome is either an X linked or an autosomal recessive disease. It is characterized by deafness and nephritis. The X linked variation is located on the short arm of the chromosome and produces the alpha 5 protein gene. The recessive form is located on the short arm of chromosome 2 and codes for collaten type IV. Treatment is at the phenotypic level.
Future Directions and Conclusion
Molecular genetics is a rapidly expanding field with nearly limitless possibilities for the treatment of head and neck diseases. Therapy of genetic disease of the head and neck is currently limited to the pharmacologic and surgical treatment of phenotypic expressions. Gene therapy, if theory is proven practical, could eliminate disease at the molecular level, thus obviating the need for pharmacologic or surgical treatment.
1) Friedman, M, Grey, P, et al. Prognostic significance of Bcl-2 expression in localized squamous cell carcinoma of the head and neck. Ann Otol Rhinol Laryngol 1998;106:445-450.
2) Davidson, BJ. The genetics of tobacco induced malignancy. Arch Otolaryngol Head Neck Surg 1993;119:1198-1205.
3) Stern Y, Lisnayansky I. Comparison of nuclear DNA content in locally invasive papillary carcinoma of the thyroid gland. Otolaryngol Head Neck Surg 1997;117:501-503.
4) Sugano S, Muka K. Immunohistochemical study of cerb B2 oncoprotein overexpression in human major salivary gland carcinoma. Laryngoscope 1992;102:923-927.
5) Kepplin, Stanley. Biochemistry Notes, Stanley Kaplan Center, Limited. 1990.
6) Thompson, Margaret. Genetics in Medicine, W. B. Saunders and Company, Philadelphia, 1991.
7) Bailey, Byron J., et.al. Head and Neck Surgery Otolaryngology, Lippincott-Raven, 1998.


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Obviously nothing is confirmed until HMX says so but this seems pretty legit.
Page 19 of the new issue of the Official Playstaion Magazine says that since the group has reunited their album Diary will be coming to Rock Band as DLC. No word on when yet, but if this is true I'm very excited

subset: commoncrawl


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The Hollywood premiere of Whitney Houston's final movie, "Sparkle," went down last night in Hollywood -- and the entire Houston clan came out to remember their lost family member.Whitney's 19-year-old daughter Bobbi looked great in a tight black bandage dress as she walked the red carpet with "brother"/boyfriend Nick Gordon, who looked sharp in a suit.The two showed off the new tattoos they recently got on their wrists, showing the initials "WH" surrounded by doves. The pair got the ink done on what would have been Whitney's 49th birthday earlier this month.Other family members at the premiere included Pat Houston, Gary Houston, Cissy Houston and Michael Houston.The stars of the flick lined the red carpet at Grauman's Chinese Theater as well.Jordin Sparks looked amazing in a full length white gown that highlighted her recent 50 pound weight loss.Other stars included Cee Lo Green, Vivica A. Fox, Christina Milian, Mike Epps, JoJo and more -- check out all the arrivals above."Sparkle" opens today in theaters.
© 2013 EHM Productions, Inc. All rights reserved. Reproduction in whole or in part without permission is prohibited.In partnership with TMZ.com | Privacy Policy


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This Crayola 96-count Crayons with Built-In Sharpener is the definitive tool for coloring fans of all ages! 96 crayons with built-in sharpener handle every coloring project imaginable. Nontoxic.From its earliest beginnings, Crayola has been a color company. Crayola came into being when cousins Edwin Binney and C. Harold Smith took over Edwin's father's pigment business in 1885. More than 120 years later, color - along with creativity, learning and most of all, fun - is the hallmark of Crayola's company. Crayola has called Easton, Pennsylvania its home since the early 1900s. Today, the Crayola's world headquarters and major manufacturing facilities are located there. And downtown Easton is the home of The Crayola FACTORY, a one-of-a-kind celebration of creative fun for everyone. In 1984, Crayola became a wholly-owned subsidiary of Hallmark Cards and has since Crayola has played the lead role in Hallmark's personal development strategies.
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What can I say, they are crayons
My daughter wanted these crayons because of the sharpener on the back. It has a lot of colors to choose from however, when she uses the sharpener, the shavings do not stay in the...Read complete review
My daughter wanted these crayons because of the sharpener on the back. It has a lot of colors to choose from however, when she uses the sharpener, the shavings do not stay in the box...now I know that she must sharpen over the trash can.
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Do not buy this item unless you expect broken and jumbled crayons. The shipping department doesn't know how to ship items that are in boxes that open easily. I complained the first time and was sent another box of crayons. It arrived with crayons jumbled and broken, out of their box again.
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By Giustina, Anthonys mommy!!
from Roseland, NJ
About Me Child Care Provider
Comments about Toys R Us 1001153 Crayola 96-count Crayons with Built-In Sharpener:
As a child I've used crayola crayons. And now at the age of 35, I still find myself coloring and using arts and crafts! I absolutely love it. These crayons are so colorful and bring pictures to life. Now my son who is only 19 months old also loves to color! And there is no other better crayon to use than crayola crayons!
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very colorful
By mother of the year
from san jose
About Me Quality Oriented
See all my reviews
Love the colors. Makes coloring contest very interesting. Lets the kids imagination run wild. Great products. Not easy to break either.
By Dwanamama
from Boise, ID
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My daughter loves these crayons. The are so many options! Really like that manyOf the newer, specialty crayons are included in this set.
Great product
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Saw this and purchased for my cousin's grandchildren. Amazing that this hasn't changed after so many years
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This is a great product for my kindetgartner. He uses them for drawing as well as when he needs them for homework and the built in sharpener is very convenie t.
crayola crayons has always been good
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crayola has always been arouund since i was kid,then my sons, and now my granddaughters. every christmas i hang the crayola ornament on my tree. then it goes back in its anniversary tin. thanks for making a great product.
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Great product - always a hit with kids. Allows creativity in children.
Better than I remember
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True full color with no white spots between. Smooth coloring and durable for my 3 year old! Plus we love to try to name the colors together. He feels brick red is hilarious.
I would buy this product again and again
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By Eli
from Los Angeles, CA
These crayons are great crayola is the only brand i trust to last long and get the job well done. My kids love these colors they use them for homework and other projects.. We love them i am very satisfied with my purchase.
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Dolce Vita
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- Modeled in size S. See fit guide for model's dimensions.
- Revolve Style No. DOLC-WF13
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Havent been able to find much information about the subject so im going directly to the source and ask.
Is PVR included and active in the eden beta builds?
XBMC 11.0 Eden: Beta2 available now
Junior Member Posts: 14 Joined: Oct 2011 Reputation: 0 |
2012-01-26 12:54
Post: #71
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Team-XBMC Posts: 9,419 Joined: Jul 2011 Reputation: 143 Location: Dawn of time |
2012-01-26 13:12
Post: #72
extracted Wrote:Havent been able to find much information about the subject so im going directly to the source and ask. This has been mentioned before many times. No it will not be standard in Eden. You can get PVR Eden builts that are made by others. Always read the XBMC online-manual, FAQ and search the forums before posting. Do NOT e-mail Team-XBMC members asking for support. Read/follow the forum rules. For troubleshooting and bug reporting, make sure you read this first For your mediacenter artwork go to |
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Junior Member Posts: 20 Joined: Aug 2008 Reputation: 0 |
2012-01-27 18:18
Post: #73
Just a quick question as I have not been able to find this and the wiki looks quite out of date (or not up to date with eden) is there a guide to installing eden beta 2 on linux. Want to move from ppa's to eden beta 2. I don't mind compiling if I have to but just wondered if there was a guide to what ppa's I should use or if I should compile.
Am running on Linux Mint 11 (so assuming Ubuntu guides will be fine as well) Sorry if I have been unable to find this myself and it is already documented. |
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Junior Member Posts: 10 Joined: Oct 2010 Reputation: 0 |
2012-01-28 00:00
Post: #74
Ive been using XBMC for about a year now. Tonight, I updated from Eden beta 1 to beta 2. Suddenly, when I started XBMC after the install, the skin had changed and all of my scraped data has gone. It started to scrape for everything. I quickly quit the program before it made too many changes. Ive spent hours getting my individual choice of covers and poster art and also correcting files which were being misread, or didnt have any covers at all.
Stupidly, I didnt backup anything, so Im worried Ive messed it all up. Does anyone know what I can do to fix this? Is it possible to recover what I had before by somehow rolling back to Beat 1? Obvoiously Id prefer to have beta 2 working, but I dont really care as it was working perfectly before I went near beta 2. Just for info, I simply downloaded beta 2 and installed it. I use win 7 64 bit. |
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Junior Member Posts: 2 Joined: Jan 2011 Reputation: 0 |
2012-01-28 03:04
Post: #75
To: djrichard:
Maybe do a system restore to a restore point prior to installing beta 2.
(This post was last modified: 2012-01-28 03:05 by dONm1166.)
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Fan Posts: 658 Joined: Feb 2007 Reputation: 0 Location: XBMC+Unraid=Happy! |
2012-01-28 03:18
Post: #76
Are there any PPA's with Beta2 for Ubuntu?
XBMC: Frodo 12.2, with Transparency! 17.5 TB Unraid Server: 2500 movies, 8800 episodes of TV Apps: SABnzbd, Sickbeard, Couchpotato, mySQL HTPC: Win8 (cause Steam), i7 920, ATI 6850 OC Watching on: Panasonic TC65-PS64 with lowend Sony 5.1 HTIB |
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Team-XBMC Developer Posts: 24,960 Joined: Oct 2003 Reputation: 144 |
2012-01-28 03:38
Post: #77
@djrichard: Are you sure you didn't actually install dharma over the top of eden b1, not eden b2. It would describe your symptoms perfectly. Log file would confirm it.
Always read the XBMC online-manual, FAQ and search the forum before posting. Do not e-mail XBMC-Team members directly asking for support. Read/follow the forum rules. For troubleshooting and bug reporting please make sure you read this first. |
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Posting Freak Posts: 926 Joined: May 2006 Reputation: 9 |
2012-01-28 22:51
Post: #78
clock2113 Wrote:Are there any PPA's with Beta2 for Ubuntu?team-xbmc/unstable |
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Posting Freak Posts: 903 Joined: May 2011 Reputation: 17 Location: Ireland |
2012-01-29 00:39
Post: #79
Is there a way I can disable scraping of movies and tvshows? I prefer to use .nfo files - now in Dharma when I would hit "refresh" on a film, it would ask if I want to ignore the .nfo file. For me, for some reason, that's not happening now.
http://forum.xbmc.org/showpost.php?p=100...ostcount=1 I'm having the most terrible time getting my things added. I just did a clean, because it seemed as if stuff was getting corrupted. I was receiving duplicates without names and plots/names that did *not* match the .nfo files. It seemed to me as if it was scrapping even though the .nfo files were there. **EDIT** I think I figured it out in part, but that makes things even more strange. If I get rid of the movie.nfo file and then name the .nfo file <moviename>.nfo - it seems to be working...sets and all. This confuses me, as under Dharma, I'm positive movie.nfo was adequate. What's been happening is it can't see, for whatever reason, movie.nfo so it's actually scraping.
(This post was last modified: 2012-01-29 00:46 by fional.)
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Junior Member Posts: 9 Joined: Jan 2012 Reputation: 0 |
2012-01-29 04:54
Post: #80
Hey, I have installed beta 2 on top of dharma... end result is XBMC hanging upon startup.... at the part where it says downloading movie information (and xeebo skin loads random items) to be precise.... looking at the logs it could be a cache error maybe??
log is below... any ideas to get this back up and running? my girlfriend will go spare if i leave it like this http://pastebin.com/Ar7F36Az (xbmc.log [27kb]) |
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St Peter's Singers of Leeds Perform Mass in b minor by J.S.Bach.
Author: hawkarine | Published: 24th February 2012 14:19 |
St Peter's Singers and Chamber Orchestra, based at Leeds Parish Church, travel to Halifax Minster on the evening of Saturday 3 March 2012 for a rare performance of Bach's choral masterpiece at 7.00 pm.
The soloists are Kristina James, Anita Wiecelewski, Paul Dutton and Quentin Brown. The orchestra is led by Mary Huby; the organist is David Houlder and the harpsichord continuo is provided by Alan Horsey. The conductor is Dr Simon Lindley.
St Peter's Singers have become especially well-known for their performance of this wonderful work since the group's first presentation of it in 1985, the special Bach Tercentenary Year, since when the work has been sung and played many times - notably in Leeds Town Hall in 1991 as part of the 150th anniversary celebrations of the consecration of Leeds Parish Church. Leeds associations with the piece extend back to the 1886 Leeds Musical Festival when Sir Arthur Sullivan conducted what was probably the first complete performance of the work in England; it is his edition that is still in regular use today.
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Published August 19, 2012, 07:28 AM
Northland Nature - August belongs to the insects
By this time of month, we're getting a good look at what August has to offer. Our days have been warm, but not as hot as earlier. Later sunrises revealing dew-covered cool mornings that warm in the afternoons and in the evenings, we note earlier sunsets.By: Larry Weber, Pine Journal


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Farrell, John Aloysius
Articles by Farrell, John Aloysius
Fox News criticized the University of Maryland for its study finding daily Fox viewers are misinformed.
But it's not to say that Obama and the Democrats don't have their work cut out for them.
Marine Captain Nathan Cox displayed a special kind of bravery by writing an op-ed in support of gay Americans.
Here are some good pieces of analysis and commentary about today's hot topics.
Henry Hudson's ruling may pave the way for an even more "socialistic" kind of healthcare system.
For the first time in 20 years, the GOP "pledge" to oppose all tax hikes has been ditched by conservatives.
It's not beyond Krauthammer to write a column meant to spread chaos and confusion among his foes.
Ohio State scientist Lonnie Thompson makes the hazy global warming debate a bit clearer.
At the very moment that Fox and O'Reilly were bashing Obama, so was Keith Olbermann on MSNBC.
If they don't like the deal Obama cut with Republicans, they should fight to kill it.


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All Britney jokes aside, this would be an amazing move for her.
According to the UK's Daily Mail:
"The 31-year old has been negotiating with one of the Caesar group hotels, with sources close to the negotiations confirming that, 'the deal is a go.'
'There are several stipulations that could throw a monkey wrench in the deal, but it's basically done.'
Apparently one of the issues holding up the agreement is the actual performance and what it will involve."
If the deal goes through, Brit could make OVER 100 MILLION a year!


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Banner AdNews-Sun file photo
The U.S. Sport Aviation Expo drew more than 16,000 guests during its four-day run last year. This year's event opens Thursday.
published: Friday, January 11, 2013 Aviation Expo sails into Sebring for 9th year By SAMANTHA GHOLAR SEBRING - Aviation enthusiasts are gearing up to flock to Sebring for the ninth annual U.S. Sport Aviation Expo. The annual event draws in thousands from all over the United States and the world. Last year's Expo drew more than 16,000 guests during its four-day run. This year's Expo is also spread out over four days beginning Thursday and will highlight hundreds of aircraft and related items from throughout the country and world. Exhibitors pile into to the Sebring Regional Airport to showcase their items for aviation enthusiasts, pilots and the general public. "We're deep into our final preparations. The extended forecast looks like we will have great weather, and our vendors and exhibitors are excited to present their wares. It's all shaping up to be a great weekend of aviation activities," Expo director Jana Filip said. The 80 indoor and 80 outdoor displays will feature some of the most up-to-date aviation-related items and equipment, and enables attendees to view and test out a number of different planes and items throughout the week. The many well-loved flight demonstrations, fly-bys, plane rides and forums are just a handful of things taking place at the Sebring Regional Airport next week during this year's Expo. The event will also house a few keynote speakers on aviation. Buzzing with plenty of activity for aviation enthusiasts, new and old, the Expo provides more than just thrills for plane lovers. History lovers will have the opportunity to tour, and may be even take a flight in, three historic World War II aircraft provided by the Wings of Freedom Tour at the Expo. The newest addition to the Expo will be the Twilight Air Shows. The shows will offer precision flying exhibitions plus a comedy flying routine showcased by some famous names in the flying world: Hall of Famer aerobatic pilot Patty Wagstaff, Tiger Air Shows "Hotwire Harry" and "Sheriff Roscoe" along with the world's largest flying team the 12-member Team AeroDynamix. The Twilight Air Shows are sponsored by the Jarrett Automotive Group Foundation and will take place Friday, Jan. 18 and Saturday, Jan. 19 at 5 p.m. Returning for its second year are the gourmet wine and cheese experiences. The food events were a big hit in its first appearance at last year's Expo so coordinators decided to bring it back for a second run. The Wine and Food Experience will be held Jan. 18-19 at 6:30 p.m. at the Tulius Hangar. Opening ceremonies for the Aviation Expo will kick off at 10 a.m. Thursday at the Sebring Regional Airport main stage. For more information visit www.sport-aviation-expo.com/. Small Banner Ads |


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Even Lehrer's obvious prompts couldn't help Obama from tripping over his own feet. Laid bare of his teleprompter and kissy media he was the empty suit on show to the world. Mitt demolished him.
As one of the heroes of 911 said "Let's Roll". As another hero said "Bring it on". The GOP-pundits-hand-wringers must STOP being concerned with the "media" and whatever "revenge" they will "seek" after the beating Mitt Romney gave obama! It's the demonrats and obama who SHOULD be worried... Buck up! Mitt Romney can take care of himself!
I agree. 100% correct. Revenge - the sick, corrupt MSM will have nothing else on their minds now. Their precious emperor was not supposed to stand exposed with no clothes, making their own immoral collusion in the charade look all the more damning. Revenge - it's on the table now.
Prediction: All the Sunday political talk shows are lining up the liberal pundits. Friday afternoon, some half baked revelation about Romney hits the news and for the remainder of the wkend, all the talk from the MSM is about this revelation and not BO's performance in the debate. Swamping every news broadcast and publication.
Outstanding! For future debates I wish they'd place a small clock in the corner of the screen so viewers can tell when a candidate runs over his allotted time.
The media has been completely negative about Romney since he was chosen as the GOP candidate. What else can they do that they haven't done already to try to bring him down?If you remember, when the GOP had multiple candidates, the MSM tried to push Romney as the front runner because they thought that Obama had the best chance of beating Romney. The laugh is on them and they are licking their wounds today. Romney came out swinging and scored a knockout last night. Now who's your daddy?
Obviously, Mitt knows what he's doing and he's getting some pretty good advice. Seems to me that in the next debate, he should spend his opening statement talking about the media and their bias, and to warn viewers to watch for bias in the questions. Then, if he really has cojones, he'll say that the president probably has the questions in advance.
Okay, so Romney has Zippy on the retreat. Now is not the time to gloat; go for the throat.
"I have been told by sources that Romney took some of his Bain salary in the form of burlap sacks instead of currency. He needed lots of sacks to drown lots of kittens.
Mitt was awesome. Had a feeling this was coming, or else why would Mitt even bother doing all this, all his money, kids, grandkids. Why take all the aggravation unless you are going "for bear".We salute you future President Romney, for your patriotism and service to our country.
They've already attacked his faith, his family, his dog, his wealth, his former career, and his ideas. The dirtbags at MSNBC even intimated that although he doesn't use caffeine, he must've been ''on something'' last night because he was so animated.It was a huge wake up call for the very people who have insulated Obama for 5 years.
BO look like a loser, which implies that his supporters, the media, are losers as well. It also makes those who have been listening to media distortions realize that they have been LIED to. People might shrug their shoulders over incompetence but when they are lied to they get mad. The target of their ire will be the media who job is supposed to be to ferret out incompetence and corruption, a job they have completely abrogated in order to support BO.The media is terrified that Romney will win, not because of the win itself but because of what will follow. Reagan won, successfully turned around the economy, and it repudiated liberal economic theory. Liberals were furious to be proven so obviously wrong that they have spent decades trying to spin Reagan's record as less successful. If Romney revives the economy it would be an even more forceful repudiation of liberal theory. The spin about BO's economy is that "NO ONE" could have fixed it, not even the great BJ Clintoon. When Romney gets the job done they will look like morons and liberals hate to look stupid. The media is far more invested in BO than they were in Carter so the resultant backlash against liberals would catch dopey media as well.As to "if the referee takes control, victory can be had!", that's not surprising. It's affirmative action for the president who obviously needs a "little" help. Is that what you want? A president of our Country who cannot get up on a stage and win a debate on his own? Someone, by the way, that was supposed to be one of the great orators of our time? The smartest guy in the room? Ha! Must have been a very small room.
#2. Yes! The GOP is embarrassing themselves being scaredycats of the media. Stop. Winners smile at the challenge which is what Romney did last night. The MSM will never change. So who cares??
The leftist media now attack full out with all kinds of lies and charcter attacks and anything they can get away with.They are determined to keep our country in control of socialists.
No Nobel Laureate seen last pm...Barry is used to getting trophies for showing up at games..doesn't work in a debate format with an honest moderator.Dishonest moderators are heading our way...
The first time one of the moderators asks trivial personal questions or a gotcha question then Romney should reply why, with all the serious problems in this country, are they playing junior high school games of personal attacks or gotcha questions? He should then refuse to answer their question.Show the members of the press who and what they truly are, to America what NAMBLA is to children and expose them by name.


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Edited information: 9/15/12 THE LAST KNOWN ADDRESS OF MIA "maliya" SZABO BERGMAN IS IN NARBERTH, PA. IF YOU HAVE BEEN SCAMMED PLEASE REPORT HER TO THEM (610) 664-8160 or (610) 664-2840 OR CALL YOUR LOCAL PD.Unfortunately as she only stole my words and while my heart has broken reading how she scammed, lied and stole from so many of you, there is little i can do. I also found out she changed her name to MALIYA BERGMAN. Here's her new blog
It was bound to happen sooner or later.
The crappy "P" word that most bloggers get hit with from time to time. You know, that word that means that content you have thought about, slaved over, and typity, typity, typed until your typer was sore was taken and put forth as someone else's work and glory.
I woke up today to information that my post on blogging jealousy had been copied, cut, tweaked slightly and pasted on the site of Miss Maria Francesca Ditas Chantal Cristina Molina Szabo. (You can all call her, Mia. Or "Coffee Girl". )
See a staggering similarity?
Some people are of the mind, "I am not going to send you to their site because I don't want to give them traffic." Which is a fine attitude to have, but frankly, I could care less about that. Go if you want and say hi to Maria "Mia" Szabo. Don't send death threats or anything, and if you do chastise her, your comments won't see the light of day as they are all moderated. I would hurry, though. I fired off a comment demanding that she take it down.
If she doesn't?
Lorelle has EXCELLENT ideas for going after someones ass when they steal content. And girlfriend left plenty of information (which I have copied and saved) to find her. Dude, don't piss me off, people. I am the most lovable person on the planet until you cross THAT line. Then? I turn into a monster of rage and storming death that flings her unteathered bosoms and wrath at lame gas station attendants while wearing pajamas and a fugly hairdo. (For the record on this post? Judy still sucks. Just in case you were wondering.)
The immature part of me wants to egg her car and toilet paper her house. Hopefully, I will calm down and realize I am 33 instead of 12 and refrain from doing so. Heh.
Seriously though, it makes me feel more than a little upset that this person has a lecture and a Creative Commons button right at the tip top of her page chastising people about stealing content!
And apparently, she is going to be a lawyer.
Balls of brass, this one has.
Let me get something straight: I NEVER MIND PEOPLE WHO REPUBLISH MY WORK WITH PERMISSION, CREDIT AND LINKS ATTACHED. I also never mind people who "Copy" an idea. I have a post and they want to take the ball and run with it, too. That is beyond flattering.
Also? When I first started blogging and was clueless about the internet I didn't understand intellectual property in regards to photos and art clips. I was stealing without meaning to. Once I learned? I try damn hard to never, ever do it. However, I have known since the age of 5 that copying other peoples written work and passing it off as your own is wrong, wrong, wrogity wrong.
Is theft.
Pure and simple.
No if's and's or but's about it.
I hate that my words have been taken and bastardized.
I almost feel like I have caught someone trying on my underwear.
It's an icky feeling, people.
A reader sent this to me. Apparently all of mianeedscoffee's accounts also link to this public bulletin about dating scam artist. The emails listed coordinate with the email information she used on this blog and so does the photo.
Seems Mia Szabo (Also known as Mia Szabo-Bautista)was a loan officer in Las Vegas who ripped off $75,000 from at least 4 people. She has also taken to posing as a representative for a consulting company lately. Color me totally not surprised.
She has a new blog: http://diaryofaretailtherapist.blogspot.com/. Invitation only. Comments closed. Go, figure. Also, her married name may now be Maria Szasbo Bergman and may be living in New York. I have no idea if this is true, nothing can be counted as truth when it comes to her, it seems. She may be faking her entire marriage on the internet for all I know.
I get emails from her victims almost every month. One victim was from SCOTLAND.
One of the saddest, sickest things I've ever seen.


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Wood Selection for Bracelet Helper Please select one of our available woods for this product. Pens & Pencils | Wood Selection
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This is not a good hostel. First of all there are no real doors. Downstairs is a pub which never closes I think, there is always loud music. You don't have a key or anything since the door is a plastic sliding door. They do offer lockers, however they are small. The rooms are really small, as is the bathroom... More
- Also Known As:
- Hanoi Youth Hotel Hanoi
- Hanoi Youth Hotel
- Official Description (provided by the hotel):
- Welcome to Hanoi Youth Hostel!Our family run hostel offers you the best hospitality in the world at its cheapest price! We are located right in the middle of the OLD QUARTER where the most famous attractions are in town. Very cool! just a couple of walk and you get to see the Lake, Don Xuan Market or the Water Puppet Theater! Our friendly and Gorgeous Staff will be more than happy to give you a map on arrival, directions, free breakfast in the morning, Free beer in the evening up on our beautiful rooftop (YES! Really!) and many other free things! We also have Wifi in every room, computers and TV's available at the lobby. One of the best things about our hotel is that it is genuinely friendly unlike other big hostel who might not have time for their customers! Every once a while, we'll take you to Karaoke or even play football with the locals!WE BEAT ANY PRICE on any tours, find cheaper and we'll make it even cheaper! ... more less
- Reservation Options:
- TripAdvisor is proud to partner with HostelWorld and HostelBookers so you can book your Hanoi Youth Hostel reservations with confidence. We help millions of travellers each month to find the perfect hotel for both holiday and business trips, always with the best discounts and special offers.


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The giant slide, the river pool with jet stream facility or the wild water canyon ensures plenty of action. Relaxation can be found in the Asian spa and in the Roman-Irish steam bath, in the sauna world or in the fitness area.
Waterpark - the source of fun
Lots of water and pure fun: approx. 2,000 square meters of water area, three giant slides and diverse pools and attractions for swimming, playing, adventure and relaxation.
Roman-Irish - the source of health
Hot steam and cold showers - Re-discover Roman bathing culture in Bernaqua. The Roman-Irish steam bath is a combination of the steam baths of ancient Rome and the Irish dry hot air baths.
Whether salt crystals, glowing coals or tropical rain: Blazing heat and icy cold are just moments away in the Bernaqua sauna world sectioned by themes. The close encounter with the elements allows you to leave everyday stress far behind you.
Spa - the source of harmony
The Bernaqua Spa promises an intensive wellness experience to guests looking for that special something. Whether Japanese "Double Spa rooms", Thai massages or floating with a view of the aquariums - the range of services here show our attention to detail.
Fitness - the source of vitality
Discover how much fun you have exercising and regain strength and vitality in our comfortable climated training area of approx. 900 square meters.
NEW: beauty area
Monday - Sunday
9:00am - 10:00pm
Monday - Friday | Saturday - Sunday |
06:00am - 10:00pm | 08:00am - 8:00pm |
Make sure to reserve ahead of time and be on time,
so that you can change without rushing and to be able to enjoy the welcome ritual. firstname.lastname@example.com / phone: +41 (0)31 556 95 40
2.5 hr ticket for fitness, sauna and water park for CHF 45.00
Family tickets available, children under 6 are free.


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Date for next auction, February 21 - 25, 2014
Made pursuant to Revenue and Taxation Code section 3702
On October 18, 2011, I, Dan M. Mierzwa, Yuba County Tax Collector, was directed to conduct a public auction sale by the board of supervisors of Yuba County, California. The tax-defaulted properties listed below are subject to the tax collector's power of sale and have been approved for sale by a resolution dated October 18, 2011 of the Yuba County board of supervisors.
The sale will be conducted at bid4assets.com, Saturday, February 11, 2012 8 a.m. through Tuesday, February 14, 2012, as a public auction to the highest bidder for not less than the minimum bid as shown on this notice. Research the item prior to bidding. Due diligence research is incumbent on the bidder. The winning bidder is legally obligated to purchase the item.
Only bids submitted via the Internet will be accepted. Pre-registration is required. Register on-line at bid4assets.com by Tuesday, February 7, 2012. Bidders must submit a refundable deposit of $2,500.00 electronically at bid4assets.com. The deposit will be applied to the successful bidder's purchase price. Deed information indicating how title should be vested is required within 48 hours after the end of the sale. Terms of payment may include EFT, wire transfers, and certified checks payments will be accepted. A Monument Fee of $10.00 per parcel, a Recording Fee of $17.00 and California transfer tax will be added to and collected with the purchase price and is calculated at $.55 per each $500 or fraction thereof. The highest bidder is required to pay in full no later than February 17, 2012 (4:00 PM ET / 1:00 PM PT) - no exceptions will be made. Settlement will be with Bid4Assets.
All property is sold as is. The county and its employees are not liable for the failure of any electronic equipment that may prevent a person from participating in the sale.
The right of redemption will cease on Friday, February 10, 2012 at 5 p.m. and properties not redeemed will be offered for sale. If the parcel is not sold, the right of redemption will revive and continue up to the close of business on the last business day prior to the next scheduled sale.
If the properties are sold, parties of interest, as defined in California Revenue and Taxation Code section 4675, have a right to file a claim with the county for excess proceeds from the sale. Excess proceeds are the amount of the highest bid in excess of the liens and costs of the sale that are paid from the sale proceeds.
More information may be obtained by contacting the tax collector at www.tax.yuba.org, or by calling (530) 749-7840.
I certify or (declare), under penalty of perjury, that the foregoing is true and correct.
(Signed) Dan M. Mierzwa, County Tax Collector
Executed at Marysville, Yuba County, California, on December 22, 2011
Published in the Appeal-Democrat on December 30, 2011, January 6, 2012 & January 13, 2012


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09 Jun 2010
Wineries on Twitter: Robert Mondavi Winery
How does the most influential winery in the United States use social media? I'm honored to have Robert Mondavi family of wineries participate in this educational series about the use of Twitter and Facebook. Undoubtedly you have drank their wine and you know their story, now, follow their tweets. Thanks to Peter Alig (Robert Mondavi wine educator) for helping share how social media can benefit wineries large and small.
Robert Mondavi on the Web * On Twitter * On Facebook
How long have you been using Twitter?
We have been using Twitter for about one year.
What prompted you to dive in?
Robert Mondavi Winery is one of the most recognized wine brands in the world. We have been in business since 1966 and have hosted millions of visitors since our founding. The major impetus for "diving in" to social media was to get a better sense of what our customers and visitors truly think about us and our wines. We also wanted to find a way to connect to wine lovers who do not get their wine information from traditional media sources.
Most important, we wanted to build relationships with and express our gratitude to as many individuals as possible who make our wines a part of their everyday lives. We would not be here without them!
What type of strategy or approach do you use when posting content?
Our strategy for posting content on Facebook and Twitter can be summarized in two questions: Does the content educate? Does the content congratulate? This strategy flows directly from the vision of Robert Mondavi, who wanted to create a new wine culture in the United States through educating visitors on the finer points of viticulture, winemaking, and wine appreciation. Social media expands our capacity to educate dramatically.
Robert Mondavi also wanted Napa Valley to become a world-class wine-producing region, and he knew that vintners had to work together to achieve this goal. When someone helps you, the civilized thing to do is say thank you, and social media helps us recognize others' successes and thank those who have helped us and/or visited us.
What have been the benefits of using Twitter/Facebook? (increased traffic, increased brand awareness, customer connection, etc)
I would say the biggest benefit so far from using social media is brand awareness. More and more of our visitors and consumers understand who we are and what we offer. This is so important.
Social media has also allowed us to nourish relationships with guests and consumers. We have had several cases of repeat guests who visited us in person, learned that we were on social media, interacted with us, and returned with friends. I don't have hard figures here, but we have begun to notice this trend.
Is there a single success story that you can point to with using Twitter/Facebook?
Yes, the first ever Napa Valley TweetUp, which we hosted on a rainy evening in March 2010. Thank to our efforts and the efforts of our dear friends in social media, the event was a great success and the Napa Valley TweetUp has become a brand unto itself. We saw a surge in fans/followers and a noticeable increase in online discussions involving us and the TweetUp.
What do you think is the single biggest barrier to why we don't see more wineries actively using Social Media tools?
The biggest barrier is simply not understanding why they should invest time and/or money in social media. Social media at its most basic is free advertising, which should pique a winery's interest, but it can be so much more. This is why your series on drinknectar.com is so critical.
What advice would you give to wineries joining the stream or getting back into the stream?
My advice is to not be intimidated by social media. Yes, you should have a plan when you begin, and yes, there are certain things you should do to get the most out your social media engagement, but don't feel like you are doing something wrong if you cannot achieve Gary Vaynerchuk-like numbers overnight.
This leads to the second bit of advice: Don't look at social media as a competition. Don't begin posting content because you want to "one-up" the winery next to you. It will backfire. Simply find your voice, find your style, and let that be your guide. You should become followers of Rick Bakas, Hardy Wallace, and Gary Vaynerchuk, the most successful social media innovators in the wine world, but your program does not have to resemble theirs to be considered successful.
What is your favorite rock band and why?
Wow, there are so many. I'm on this reggae kick right now, so I am thrilled that the great Ziggy Marley will be performing at the winery on July 16.


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Complete With 2 x Aprons
Order in the next 8 hours 12 minutes for express home delivery on Monday
I didn't realise that some prams come with aprons and some with rain cover . Minę didn't have the rain cover and I would definitely prefer it than aprons. Fortunately it costs only around 15 pounds. Very heavy pram but overall I'm very happy via what do u expect if it's for 2 kids . Love it. Just saved 300 quid by choosing this one instead my first choice
This pushchair is ideal if you have 2 children under the age of 2! It's easy to put together and after collapsing it and putting it up is a one handed job (brilliant when your trying to stop a toddler running away from you in the car park!) the steering is so light when you've got the swivel on the wheels it gets round even the smallest of shops. The only thing I will point out is there's no cup tray on the front for your older child which is a shame because there's one on the back for the smaller child???? Also it doesn't come with rain covers although the video makes it look like it does so be aware you'll have to buy that separately which for the price you've paid for the pushchair they should be included. It does come with 2 aprons tho so that's a plus. They're nice and easy to attach but not a patch on a decent footmuff!
We have search through all the tandem buggies in this class (£130 - £400), also looking at the prams which start from around £400-£1000.We wanted a tandem over a side-by-side, as we knew this would definately fit through our front door. Although this is one of the most expensive tandem strollers it is definately worth the money. We are expecting our new baby in March when our toddler is 15 months old. We looked at Graco Stadium and all other models available here and on other sites in our local chain 'baby store'. We were disappointed with the build quality of all. All seemed flimsy, though they are strollers. For the newborn in the back, most had 'gaps' between the seat unit and hood when reclined, which concerned me - I don't my newborn exposed to cold winds blowing through the stroller. The seats weren't well padded also. Some might say I'm being fussy, but I just wanted to find value for money - with quality. I was so pleased when the quattro duo arrived after we ordered it (we wanted to try it out, as we couldn't find it in a show room anywhere). All the seat units zip into the hoods, leaving no air gaps - so no chilly newborn. Great features: solid contruction, really easy collapse and set up, no bigger than our SC freeway pram to fit in boot of VW Passat estate, well padded seats, solid recline mechanism, huge basket, easy steering, don't find it any heavier than my current pram. My husband loves the height of the handles also. It is really solid and makes a reassuring 'clunk, click' sound that quality prams make when being put up or down. Only negatives - me being fussy...raincover not included (but def worth buying separately). 2x aprons included - I preferred the look of the graco cocoons (as these are zip lined, so less draught) so ordered these - the aprons don't zip on, so i still feel my littles ones legs might get chilly. Though other people might be perfectly happy with them. Well done kiddicare - you also proce matched this for me, so feel like we had a real bargain! I would definately recommend this to a friend - if you feel the cheaper models aren't quite what you;re looking for, but don;t want to break the bank - this is for you.
Easy to put together, great delivery system, would definately use again
Havent used this yet as baby hasn't arrived yet, my toddler likes sitting upfront as can sit right up a nd looks round at the world(only tried him in for few minutes). It seens very long but sporty and quite sturdy, folds down to good size so fits in boot. Looking forward to trying this out next month ;). Shame that item doesnt come with a raincover, more expense :(
These are exclusive customer reviews unless otherwise stated. Specifications of goods are subject to change.
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This product is available as a pre-order. This means that we do not currently have the item in stock but we are expecting it shortly. You can place an order for this product now your expected shipping date will be 07-05-2012
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Hotel Amarano Burbank322 North Pass Avenue, Burbank, CA 91505 (Show map)
Very good
Score from 77 reviews
front desk staff restaurant waiter housekeeping valet lovely bar area rooms very nice with green amenities
Location was good, close to 134 Fwy, quiet and had walkable, convenient shopping across the street. Excellent room service menu!
San Jose
The comfort,staff and freeway access
Morgan Hill
I like the location and the decor of the hotel. It is modern, comfortable and a hidden gem.
Los Angeles
I like the set up , very nice.
Sun Valley
everything was great
Great location, nice facilities.
North Lakes
the outward appearance was luxurious, safe neighborhood. pool staff courteous.
Santa Cruz
Nice size room with a fridge. Location
Toms River
It was super comfortable!
A 15 minute walk from the Warner Brothers Studio, this contemporary Burbank hotel features on-site dining, a hot tub and a roof top terrace featuring city views. All rooms include free Wi-Fi. The Hotel Amarano Burbank features comfortably furnished rooms with luxury linens, a bathrobe and minibar. A flat-screen TV with complimentary satellite and an iPod docking station are included. The Privato restaurant serves California cuisine and features an extensive wine list. Guests can dine indoors by candlelight or alfresco on the exterior patio. The Library Lounge offers American fare and a variety of cocktails. The Burbank Hotel Amarano offers room service options. This hotel offers a free shuttle service to Universal Studios just 2 miles away. Discounted tickets are available. The Greek Theater is a 15 minute drive away. Hotel Rooms: 132 The most recent booking for this hotel was made on Dec 13 at 2:04 AM from the United States.
OutdoorsGrounds, Terrace, Sun Deck, Outdoor Pool ActivitiesNewspapers, Fitness Center, Massage, Hot Tub, Library Food & DrinkRestaurant, Bar, Breakfast in the Room, Special Diet Meals (upon request) InternetFree! Wi-Fi is available in all areas and is free of charge. ParkingPrivate parking is available on site (reservation is not needed) and costs USD 35.84 per day. Services24-Hour Front Desk, Baggage Storage, Room Service, Meeting/Banquet Facilities, Business Center, Babysitting/Child Services, Laundry, Dry Cleaning, VIP Room Facilities, Honeymoon Suite, Car Rental, Tour Desk, Fax/Photocopying, On-Site ATM, Concierge Service, Shuttle Service (Free), Airport Shuttle (Free) GeneralNon-smoking Rooms, Facilities for Disabled Guests, Family Rooms, Elevator, Safe, Heating, Designer Hotel, Hypoallergenic room available, Air Conditioning Check-inFrom 3:00 PM Check-outUntil 11:00 AM Cancellation/
Total Hotel Score:8.4
Based on 77 reviews Guest reviews are written by our customers after their stay at Hotel Amarano Burbank. |
Score breakdown
Score Filter |
The bedding
front desk staff restaurant waiter housekeeping valet lovely bar area rooms very nice with green amenities
male bartender at night quite rude very noisy in rooms 106 & 105 until late at night due to party in bar. shuttle bus unreliable in terms of getting back to us by phone & letting us know if they still had us on pick-up list
Location was good, close to 134 Fwy, quiet and had walkable, convenient shopping across the street. Excellent room service menu!
I liked how the staff was very friendly and helpful. I loved the hotel room, the sheets and bedding were so comfortable. It was located within 10 min of where I needed to be. It has a grocery store across the street and quite a few delicious eateries nearby. I loved how you could open a door/window and have a fresh breeze. Overall I loved this hotel and would probably come back again. I have already referred a few family members and friends there!!
I didn't like that the pool area closed at 10pm. I wish they had designated free parking instead of just parking on the street in the neighborhood behind it. However, I do like that they tell you about that option and assure you it is a safe neighborhood.
We stay there every year for a golf tournament in September. I took my kids to Universal Horror nights Oct. 31St 2013. This is the only hotel in the area that has one bedroom suites so I booked it. I like the location, the large one bedroom suite, and all the staff. Front desk, maids and especially the valet guys. Excellent service. The hotel is right across the street from Vons, Original Bob's big boy and a breakfast place called Patys.
The pull out couch bed was uncomfortable. Parking was expensive. $32 per night. I did encounter a problem when booking this hotel. I called the hotel direct first and the girl said that the suites were sold out for Nov. 1St. Immediately upon hanging up the phone I called booking.com and they made a reservation for me and were able to get me the one bedroom suite for the 1st. I had no problems checking in. I would use booking.com in the future.
The comfort,staff and freeway access
Cost of parking. The coffee maker didnt work and I paid more than I was quoted.
I like the location and the decor of the hotel. It is modern, comfortable and a hidden gem.
What I didn't like about the hotel was based on my last visit. There was a big spider in the bathtub. This was probably because we were on the first floor and it crawled in from the patio. Later that day, I noticed a bed bug on my pillow. After that, I noticed a moth on the curtain. The front desk sent housekeeping and they changed the sheets however, I still felt awkward.
I like the set up , very nice.
Didn't like that room service was persistent on wanting to vacuum the room .. I couldn't be comfortable in my own room with feeling nervous on someone walking in .. This person knock and open the door while me and my partner were in the shower...
everything was great
Great location, nice facilities.
Staff were vrey nolisy in the mornings. Didn't seem to be aware the guest were resting.
the outward appearance was luxurious, safe neighborhood. pool staff courteous.
light switch was broken, under the bed was not vacuumed well; the bathroom lighting was dim and the shower not powerful.
Nice size room with a fridge. Location
price of the room for the night $33 for parking
It was super comfortable!
I did not like the laundry room next door to my suite keeping me awake all night.
Comfortable beds. Bathroom is little bit old but ok. Nice pools.
Valet parking only and costs $30+. It is slow.
Easy parking, near Porto's, nice pool
Poor cleanliness, baseboards, wall, poor drainage in bath/shower
Great place to stay while visiting Universal studio. Near by supermarket, great for kids needs
Parking cost is 30$ per day, too expensive! Without a reason
a very very good hotel, the room is clean and the staff was very kind.
Close to North Hollywood and universal studios and shopping
We have to pay for parking lot Breakfast not included
Cost for valet parking. Did not know this till I booked it.
Beds were comfortable, rooms clean, staff very friendly and attentive. Small hotel with great guest services.
Paying for parking.
very pleasant stay. was familiar with the hotel and it was as lovely as i remember it to be.
The Library, pool, room design and staff.
The duvet kept slipping off the bed. The ice machine wasn't working near our room. There was supposed to have been a microwave in room.
The room was fantastic, very comfortable, the staff was very friendly and helpful. It was great to be across from a very delish breakfast place BeaBea'S.
That I had to leave
good room size and comfortable bed
bathroom is a bit old
The guest reviews express the personal opinions of Booking.com customers who filled out a questionnaire after their stay at the hotel. These opinions do not necessarily represent the views of Booking.com.
Los Angeles Marriott Burbank AirportLocated near Burbank Airport, this modern hotel offers 2 outdoor pools and a state-of-the-art fitness center. It is close to Universal Studios and other popular Hollywood attractions.Most recent booking for this hotel was today at 00:15 from $99 |
Sheraton Gateway Los AngelesLocated 4 miles from Dockweiler Beach State Park, this modern hotel provides free 24-hour shuttle service to Los Angeles International Airport, one mile away. It features on-site dining.Most recent booking for this hotel was today at 04:18 from $95 |
Best Western Burbank Airport InnThe Best Western Burbank Airport is located in North Hollywood, California. Universal Studios and City Walk are just minutes away. Complimentary breakfast is served daily.Most recent booking for this hotel was today at 03:19 from $77 |


text:
Mich. man whose wife died of meningitis being treated in hospital
George Cary whose wife died of meningitis says he's in hospital with same illness
A Michigan man whose wife died in a national outbreak of meningitis says he's in a hospital being treated for the same illness.
George Cary says he began having severe headaches Friday, just days after being told that initial tests in early October showed no evidence of meningitis.
The 65-year-old Livingston County resident didn't disclose the name of the hospital in his Wednesday statement provided to The Associated Press.
George Cary and his wife, Lilian, were treated for back and neck pain at a Brighton-area clinic that used contaminated steroids made by a Massachusetts pharmacy.
The tainted drugs have been linked to an outbreak of fungal meningitis that has sickened more than 300 people nationwide and has killed 23.
Copyright 2012 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
A Bible Lesson for Rick Santorum: Why It's Not Immoral to be Gay
Read More:
Rick Santorum Homosexuality,
Gay Rick Santorum,
Gay Marriage Rick Santorum,
Rick Santorum Gay,
Homosexuality Rick Santorum,
Rick Santorum Gay Marriage,
Bible Rick Santorum,
Canada News
I would never cast moral judgment on those who are gay. The Bible prohibits homosexual acts, and I can never argue with that, but in accepting the commandment I can say: "It is my law and I do not claim to understand it." The entire Torah can be summarized in the teaching: "Love your neighbor like you yourself."


text:
Very basic hotel. Clean but not exceptionally comfortable. Limited opening hours for reception could also be a problem. A good 25 minute walk from the train/coach station wouldn't be much fun in rainy weather.
France >
Brittany >
Finistere >
Free High-Speed Internet
Free Parking
Pets Allowed
Room Service
Ranked #19 of 37 hotels in Brest
Price range (per night):
$68 - $77
- Reservation Options:
- TripAdvisor is proud to partner with Booking.com and Priceline so you can book your Little Lodge Hotel reservations with confidence. We help millions of travellers each month to find the perfect hotel for both holiday and business trips, always with the best discounts and special offers.


text:
New Project in Progress:
Working progress from Jennifer !
pic 1 - drawing into the blackened plate (the waxed surface of the metal plate is made black by burning it in candle flame)
pic 2 - adding Bitumin paint to the plate where I don't want the acid dip to eat at the metal
pic 3 - the plate about 45 minutes later (it has been sitting in a liquid that eats the metal thus making the lines where it has been exposed)
pic 4 - a close up. The final print is yet to come!
pic 5 - squeezed this in to show a happy mistake - this is Foss the Cat (Lear's sidekick) that I wanted to make a postcard from. I used the Dry Point method for this but didn't dig deep enough so it came out very light… but looks quite fluffy! Quite nice to see the mistakes sometimes..


text:
New faces becoming household names for Lemont football
Every football season brings with it change as former players graduate and new names gain recognition for their exploits on the fields. From a junior contributing for the first time to underclassmen making big impacts, these breakout players are helping Lemont achieve this season.
Jimmy Kepouros
Position: Wide receiver
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text:
By Rob Kuznia
Staff Writer
Students at Hawthorne High might want to add earplugs to their back-to-school shopping lists.
When they return to campus on Aug. 27, they'll find that up to 40 percent of the campus is ripped up and under construction - and the din of progress will last all through the school year.
The construction is the fruit of a $98 million facilities bond approved in 2010 by voters in the Centinela Valley high school district, which serves a low-income population of students at three high schools: Hawthorne, Leuzinger and Lawndale.
Centinela Valley isn't the only South Bay school district where campuses are getting extreme makeovers. Anderson Elementary in Lawndale and Fern Elementary in Torrance will soon open brand-new wings for their fourth- and fifth-graders. A new elementary school just opened in Wilmington, and San Pedro High recently unveiled a sparkling new satellite campus a mile south of the main plant.
But the construction in the Centinela Valley school district amounts to the largest work in progress.
The 2010 bond measure - as well as another for the same amount approved in 2008 - is bringing state-of-the-art school buildings to a group of students who have long endured crumbling facilities. (Hawthorne High, for instance, has experienced few changes since the Beach Boys attended the school in the late 1950s.) More than a third of the money comes from a lucrative corporate corridor in eastern El Segundo that includes the likes of Mattel, Xerox, Raytheon and Northrop Grumman.
"Before the end of this month, we will probably have contracted $100 million worth of work at all three sites," said Jose Fernandez, superintendent of the Centinela Valley Union High School District. "That's probably the largest local public investment in this region in decades."
And that doesn't even include the glassy new half of Leuzinger High that was unveiled this time last year. It was a transformational project that - with its lush landscaping and Greek-style outdoor seating areas - has given the campus the look and feel of a community college.
Now, the district is gearing up to begin the next phase of the Leuzinger campus, which will include a culinary arts academy and a new cafeteria.
Also in the offing is an overhaul at Lawndale High, where demolition crews have already razed old buildings.
"Lawndale is a clean slate," Fernandez said, adding that bids for that project are due next week.
At Hawthorne High, buildings have been leveled along El Segundo Boulevard, where the main entrance once existed. (The front doors are now temporarily located on Inglewood Avenue, just south of the school's pool.) This means that when the construction fencing comes down along El Segundo Boulevard, a once-controversial crown jewel will be visible to passing traffic: the school's seven-year-old, two-story dining hall. One of the campus's only new structures, the cafeteria was derisively labeled the "Taj Mahal" by critics of the district's management of a $59million bond back in 2000.
The centerpiece of the ongoing project will be a gleaming science center with 14 classrooms in the southeast corner of campus. That addition will evoke the same college-campus feel of the new structure at Leuzinger.
"It will be a tiered setting," Hawthorne High Principal Mark Newell said. "It will also look nice visually from the streets. It will be kind of a focal point at Inglewood (Avenue) and El Segundo Boulevard."
The science center and the other buildings currently under construction - such as a media center and counselor-and-student-services building - are slated to open in the fall of 2013, Fernandez said.
In the meantime, many Hawthorne High students will spend much of the coming school year in temporary portables. Even if the new buildings come online in 2013-14, the portables aren't likely to go away that year: That's when Hawthorne High is slated for yet another phase of construction, which will produce a school of engineering with 21 classrooms.
"It's going to create a very much-needed new look," Newell said. "Hawthorne High School was first erected in 1953. It's time that we put our physical plant into the 21st century."
Follow Rob Kuznia on Twitter at http://twitter.com/robkuznia


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ArchiveNew MediaArt News from Elsewhere 2013
44 Items
Art News from Elsewhere
LACMA ArtTech
Via nytimes.com
Dec 10
Fifty years after LACMA launched its Art and Technology program, which pairs artists with science, engineering, and tech companies to promote collaboration, they're doing it again. Part of the museum will be transformed into a lab that will open early next year.
Art News from Elsewhere
Title Fights
Via artnews.com
Dec 9
Rebecca Uchill's "Random Exhibition Title Generator" captures the absurdity of naming conventions for many art shows—down to the colons, parentheses, and words like "praxis." But the naming process, writes Ann Landi, isn't as easy as the one-click site suggests.
Art News from Elsewhere
Google Hands
Via newyorker.com
Dec 5
Kenneth Goldsmith discovers a small but thriving subculture of people obsessed with documenting errors in Google Books—from digital glitches to hands of unseen laborers (or "Google hands") accidentally captured by scanners.
Art News from Elsewhere
Animating HUO
Via animalnewyork.com
Nov 26
Hans Ulrich Obrist's animated head—accompanied by a Nine Inch Nails/Carly Rae Jepson mashup—chatters in Ian Cheng's trailer for the new book Think Like Clouds, a collection of diagrams, notes, and drawings the famed interviewer jots while chatting with artists.
Art News from Elsewhere
Feminist Selfies
Via hyperallergic.com
Nov 26
In response to a Jezebel post headlined "Selfies Aren't Empowering. They're a Cry for Help." Twitter users have started the #feministselfie hashtag. Their images, writes Alicia Eler, "help us understand who controls the mirror and who's allowed to make images."
Art News from Elsewhere
NSA & Free Speech
Via nybooks.com
Nov 20
"Robust speech suffers when privacy is imperiled," writes Kenneth Roth of NSA surveillance and online free speech. To thwart the NSA, he adds, Internet companies may opt to keep servers within their own countries—under closer observation by repressive governments.
Art News from Elsewhere
Digital Sculpture Park
Via npr.org
Nov 4
Examining the growing acceptance of digital art, NPR points to ifnoyes.com, a website purchased by Benjamin Palmer at auction last month. It's like owning a sculpture in a park, says artist Rafaël Rozendaal: it's public, but part of a personal collection.
Art News from Elsewhere
Postdigital Art
Via newyorker.com
Oct 24
Artists used body scanners, 3-D printers, and an Xbox controller to create the works in MAD's new exhibition Out of Hand: Materializing the Postdigital. Curator Ronald Labaco proclaims, "The digital revolution is over, and it has now become commonplace."
Art News from Elsewhere
Via omnireboot.com
Oct 15
Following up their last work, Webcam Venus—in which they asked sexcam workers to copy poses from art by the likes of Delecroix and Degas—Addie Wagenknecht and Pablo Garcia are back. They're aggregating sexcam streams, but only when the performers are absent.


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Freshwater Cultured Pearl and Diamond Earrings in 14k White Gold (6-6.5mm)
4,6 out of 5 (15 Reviews)
Subtle undertones of rose characterize our freshwater cultured pearls, each accented by a single round diamond and mounted on 14k white gold posts with push backs.
More Reviews
Results: 15 Reviews
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4,6 out of 5
(15 Reviews)
5 Stars
4 Stars
3 Stars
2 Stars
1 Star
My daughter loves these earrings
I purchased these earrings for my daughter's 21st birthday. they aren't to big nor to small - they're just right
simple and elegant
Paired with the necklace, or along, just what I was looking for to give my wife.
Lovely Valentine's Day Gift
I am very pleased with the earrings. I surprised my daughter with them for Valentine's Day. Although she was a little under the weather, she was very happy with them. They are quite beautiful and exceed my expectations.
Perfect wedding earrings
The earrings are gorgeous! I will be wearing them in my wedding. I love the size!
Beautiful, just as promised on web page.
The earrings are beautiful! Ordered them for my daughter and she loved them! The shine was nice. The pearl quality is also very good. No Blemish at all. Shipping was on time.
She has them on all the time.. lol
They seem delicate, but look better than I thought. Well worth it! I couldnt be happier with my purchase.
Another good experience with Blue Nile
These earrings were exactly what my fiance was looking for. The product received perfectly matched the description given on the website.
She loved them. I should have gotten them one size bigger, but they were exactly what I ordered. Your company is fantastic!
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When we heard of a plan to combine the Lee County Reference Room with the Johann Fust Community Library, we asked the Fust Library's Vice President, Alice Gorman, for her input. This article was written by her, and represents information from both librarys' staff.
BY ALICE GORMAN - Everyone in Boca Grande loves the Johann Fust Community Library. The building, with its gracious gardens on 10th Street that was given to our community by the Roger Amory family, is an institution that has continued to be a place of serenity and literary resources since 1949.
Last winter, the board circulated a survey in front of the Boca Grande Post Office that asked the community for its thoughts and opinions on our library system. The results that came back gave us a clear path to the answer to the problem.


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Hotel Senator-Ház is a three star hotel with 11 rooms in the heart of Eger, just across the bridge...
morePark u. 6, Szilvasvarad, Miskolc, H-3348, Hungary
14 Bajcsy-Zsilinszky Street, Balaton, 8220, HU
This was a very pleasant hotel, very close to the center, and should have been the perfect weekend...
moreDouble room, 81 € (B&B), free parking in the complex (Aug. '07). - Fax: (+36) 413 114
moreTunderpart 5, Eger 3300, Hungary
Satisfaction: Terrible
Good for: Families
We actually booked a room in the neighboring Senator Haz Hotel, but due to overbooking we were sent...
moreFurdo Utca 5, Eger, 3300, Hungary
Satisfaction: Average
Good for: Couples
Knezich K.u.4., Heves County, Eger, 3300, Hungary
Satisfaction: Excellent
Good for: Couples


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Welcome back
Remember to renew your season ticket before 31 May to secure your seat for next season.
Christmas is coming so get everything you need from our online store today. From Replica kit to Toon souvenirs we have it all!


text:
Keep your TiVo DVR at your fingertips at all times with the convenient TiVo app. Browse and schedule recordings from wherever you happen to be. With a Roamio Plus or Pro, you can even stream your shows around the house or load them up and take them to go (iOS devices only).
TiVo app for smartphones and tablets
A groundbreaking way to interact with your TiVo DVR
Hold the power of TiVo in the palm of your hands by turning your iPad or iPhone into command central for your TiVo DVR. Download the free TiVo App for iPad or iPhone and search, browse, schedule and share without interrupting what you're watching.
Use it on the couch for a richer TiVo experience, or use it while you're out to browse and schedule. Turn your iPad or iPhone into the ultimate TiVo companion today and take your TV-watching experience to a whole new level.
Note: You must be connected to your home WiFi network to enjoy all the features that are available.
Compatible with iPad®, iPhone®, iPod touch®. Requires iOS 5.1 or later


text:
Blackberry AccessoriesLooking for a complete range of BlackBerry accessories? BargainCell.com has all of the Blackberry accessories that you require under a single roof. From Blackberry chargers to BlackBerry USB data cables, hands free headsets to leather cases, Blackberry car chargers and more can all be found at BargainCell.com! Whether you are looking for an OEM or non-OEM BlackBerry battery, you will find all them all and more at an affordable cost from BargainCell.com. Shop now for BlackBerry accessories and get the home travel charger for BlackBerry, BlackBerry Curve 8330 Curve OEM skin, BlackBerry 8310 curve OEM skin or BlackBerry Curve 8900 screen protector you're looking for. |
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text:
What Happened to My Little Girl?
Price: | $6.99 |
Choose a Retailer Below
A girl learns as much about being a woman from her father as she does from her mother – and the learning starts much younger than we think. Tween expert Nancy Rue, and her husband, Jim, guide fathers in relating to their tween daughters as they make the transition from girl to young woman.
Download - Audio, Unabridged$12.99
Dads, finally a guide to your tween daughter! This companion book to the FaithGirlz novels, devotionals, and Bibles, focuses on four tween issues – appearance, body and mood changes, girl politics, and authenticity.
Let tween expert Nancy Rue, and her husband, Jim, guide you in helping your daughter live as a girl-child rather than a mini-teenager. Empower her in spiritually sound behaviors as the rate of aggression rises among tween females. Show your daughter how to not only avoid but take a stand on the twisted parts of her culture such as peer abuse, shallow consumerism, and an unrealistic sense of entitlement. Give her alternatives to the toxic media, and encourage her to become part of something bigger than herself through charitable, God-centered activities. Learn to model the growth of a deep, personal connection with God, which makes all of the above not only possible, but probable.
In the midst of a world saturated with poisonous role models, it is possible to raise your daughter to be a respectful, confident, God-centered, young woman.