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209 West 40th, 5th Floor, NYC 10018
Our new address is:
209 W 40th Street, 5th Floor 10018
(Near the corner of 7th Ave)
We are excited to announce Funkadelic Studio's move to a brand new location! We have finished construction on the entire space and it is ready for you to rehearse! Now, moves can generally mean "more expensive for you the consumer" but this is certainly not the case! You can still expect the same great rates, services, and options offered from Funkadelic Studios. We offer three 9×12 rehearsal rooms, six 12×15 rooms, and one large 17×26 room for all your rehearsal and showcase needs. In addition, we will have a revamped recording studio, repair shop, and will offer equipment rentals. There are also several new showcases, events, and seminars in the works so keep in touch with us and pay us a visit! Spread the word and come on down to Funkadelic's new home:
209 West 40th st (between 7th & 8th aves) 5th floor
New York, NY 10018
We Are Open F0r Business!!
Funkadelic Studios runs on a simple philosophy: the musicians are the priority.
Funkadelic Studios has provided musicians an affordable home to rehearse, record, and reinvent their music for over 20 years. Two musician friends in Brooklyn started the studio as a way to connect with the NYC music scene and provide a place where musicians can do what they do best – make music. No matter how rich, poor, established, or underground an artist might be, Funkadelic provides all the services musicians need under one roof. The six Rs are essential for any artist and Funkadelic has them all covered: rehearsal rooms, recording studio, repair shop, rentals, retail shop, and a rock & roll club.
Multi-national touring artists have rehearsed at the same rehearsal rooms as young musicians writing their first few songs; first electric guitar owners take their guitars to be repaired by techs who repair professionals' gear; acts recording their first demos record in the same studio used on popular recordings in various media outlets. This sense of community and artist support is what gravitates many artists towards Funkadelic Studios.
Beyond rehearsal and recording, Funkadelic provides other great outlets for artists to showcase their work. Open Mic Nights, Open Jams, Event Showcases, EP/Album Release Parties, and Talent Competitions are only a few of an extensive list of services we provide musicians to help network and promote their art. We take the extra step to help the music community keep in contact with their fans, other musicians, and industry professionals. Funkadelic Studios understands that music isn't just about a group of songs or compositions, it is about people: people who write the music, people who help with the technical aspects, and people who listen to it.
For a full list of services, please refer to the list on the top of the website.


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Frankly, she isn't alone in this kind of thinking.
Our public understanding about how racism works today is thwarted by the personalized response that focuses on intention, rather than action.
"Good" people are very often blind to and support disturbing and discriminatory actions, behaviors and ideas. Today, there is widespread normalized racial discrimination. One study shows that white job applicants with a criminal record are nearly twice as likely to get a call back for low-wage work than equally qualified black applicants with a college degree and no criminal record.
For this apology tour to do real good, Deen might consider taking an anti-racist position, reaching out to black people and honoring the pain many face as a result of serious racial discrimination, and thinking about how she might have contributed to it.
Deen might use her extensive media platform to draw attention to racial injustice today, to show the broader public just how much it saturates American society, even for those who think they are above it.

subset: commoncrawl


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The FDNY will kick off Fire Prevention Week 2011 on Sun., Oct. 9, with public events throughout the five boroughs.
At each event, New Yorkers will be able to interact with members of the FDNY Fire Safety Education Unit and learn valuable, life-saving lessons in fire safety.
National Fire Prevention Week was established in 1922 to commemorate the Great Chicago Fire on Oct. 8, 1871, which killed more than 250 people, left 100,000 homeless and destroyed more than 17,400 structures. Fire departments throughout the country have since commemorated the anniversary every year, in the second week of October, by informing the public about the importance of fire safety and fire prevention.
The FDNY's Fire Prevention Week events include:
Sun., Oct. 9, 2011 Sears 404 East Fordham Road, Bronx 11 a.m. - 3 p.m.
Queens Center Mall 90-15 Queens Boulevard, Queens 12 p.m. - 4 p.m.
Mon., Oct. 10, 2011 Lowe's 2171 Forest Avenue, Staten Island 12 p.m. - 5 p.m.
Tues., Oct. 11, 2011 FDNY Fire Prevention Week at Rockefeller Center hosted by Tishman Speyer Rockefeller Center - 50th Street between 5th and 6th Avenues, Manhattan 10 a.m. - 2 p.m.
Lincoln Hospital Fire Safety Day 234 East 149th Street, Bronx 11 a.m. - 4 p.m.
Thurs., Oct. 13, 2011 Jacobi Hospital 1400 Pelham Parkway South, Bronx 10 a.m. - 4 p.m.
Fire Safety Day at Metrotech Commons Jay Street and Myrtle Avenue, Brooklyn 11 a.m. - 2 p.m.
P.S. 173 After School Program 306 Fort Washington Avenue, Manhattan 2:30 p.m. - 6 p.m. (This event features singing firefighter El Bombero Rapero)
Fri., Oct. 14, 2011 Mount Loretto/CYO Senior Information Day - Hosted by Senator Andrew Lanza 6581 Hylan Boulevard, Staten Island 9 a.m. - 12 p.m.
YAI/National Institute for People with Disabilities 82-24 209th Street, Queens 12:30 p.m.
J.H.S. 143 Alianza Dominicana After School Program 515 West 182nd Street, Manhattan 2:30 p.m. - 5:30 p.m. (This event features singing firefighter El Bombero Rapero)
Sat., Oct. 15, 2011 Kings Plaza Shopping Center 5100 Kings Plaza, Brooklyn 12 p.m. - 4 p.m.


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Stork's IPO ambitions may be hit by opposition to fighter jetsThursday 05 July 2012 Possible plans for a stock exchange listing by industrial group Stork could be thwarted because parliament no longer backs buying the JSF jet fighter, the Financieele Dagblad said on Thursday. In particular, the Fokker Technologies division is likely to be hit, Stork's chief executive Sjoerd Vollebregt told the paper in an interview. 'Separate listings of the two divisions Fokker Technologies and Industrial Services is not the only option but the one we prefer,' he said. 'But you need a certain size to do that, and if the JSF goes, Fokker will be too small to list,' he said. Opposition When the project was first put forward in 2002, the cost was put at €4.5bn and the first plane was due to be operational in 2014. The price of the 85 aircraft has now risen to over €64m each, with an initial delivery date of 2019. However, RTL news reports that ministers will ignore a motion calling for the pull-out which is likely to be backed by MPs later on Thursday. As well as Stork, other Dutch firms have warned of the knock-on effect of pulling out of the project, which is expected to generate billions of euros in orders for Dutch firms. The contracts are conditional on the Netherlands buying the finished planes. The FD says Stork has the biggest financial interest in ensuring the project continues. Should we pull out of the JSF? Have your say on the comment form below © DutchNews.nl Readers' Comments This is silly, the average price of a eurofighter and Rafaler per unit is well over 100 million euros and the dutch govt. is wanting to scrap the deal because the price is at a little over 64 million, this is ridiculous. You are getting a 5th gen fighter for the price of half a rafale or Eurofighter. not to mention sourcing that will happen for over 4000 plus aircraft to be built in the future. sheer lack of long term thinking. Stop being silly JSF is good for the dutch economy on the long run. By 5 July 2012 10:16 AM |@Immanuel The export fly-away price for Eurofighter was documented at €62 million each, with some discount (Austria sale) By 6 July 2012 4:07 PM | |
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Originally from New Orleans, Jim Ford lost interest in his academic pursuits and, in 1966, drifted out to California. He was passing through L.A., on his way to the Haight-Ashbury district in San Francisco, when he met two session musicians, Pat and Lolly Vegas. The Native American rockers -- who later formed the commercially successful Redbone -- had worked on the Shindig television show at the time, and had already recorded their Pat and Lolly Vegas at the Haunted House album for Mercury. After hearing his songwriting talent firsthand, the Vegas brothers brought Ford to the attention of Del-Fi Records' honcho Bob Keane, known around the L.A. music scene for his "open-door policy." Keane released a couple of Ford's singles on Del-Fi's Mustang label, both of which sank without a trace. Del-Fi/Bronco recording artist Viola Wills also recorded one of his songs. Along with Pat and Lolly Vegas, Ford wrote the P.J. Proby hit "Niki Hoeky" (it peaked at number 23 on Billboard's pop charts in January 1967), which Ford's former girlfriend Bobbie Gentry also sang on one of her later albums.
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Brand store calendar for June
Brand store calendar for June
Posted by Huw, 24 May 2013 17:25. Filed under shop.LEGO.com (UK).
Rich at BrickFanatics has just posted details from the June calendar:
- Tower of Orhtanc available from 17th June to VIP members, as stated before.
- Summer City, Chima, Star Wars and Galaxy Squad will be available from the 1st.
- Spend £25 or more and you'll get a free TNMT Splinter key ring, spend £50 or more for the Jor-El polybag. (No idea if they stack or not, but probably not).
And, the Glasgow store grand opening event will be held 7 - 9th June with the usual selection of freebies to the first customers each day.
Also, we're hearing from various sources (including Kockamania) that the Back to the Future Cuusoo set will be available in August!
14 comments, latest one posted 6 months ago. (Commenting has ended on this article)3101 views


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« back to David Olive's Everybody's Business
« March 2010 | Main | May 2010 »
When Dubya was dipping to 28% in the public-approval ratings, defender Larry Kudlow decided the rising arc of stock-market performance was a better measure of the president's job performance than the seven consecutive years of triple-digit deficits, the biggest American foreign-policy blunder in modern times in Iraq, and the rank incompetence in losing a great American city at the mouth of the Mississippi.
It was the over-heated stock market of 2007, coinciding with a record, unsustainable U.S. housing bubble that inspired Kudlow's praise of Bush 43. Within a year, the market was crashing by more than 40%, and Americans were understandably afraid to look at their 401k statements.
Here's Ludlow in 2007, just before the epic stock-market crash:
This brings me to a larger point. Despite the criticism President Bush has received over his Iraq War policies, isn't it interesting that stock markets have been booming since early 2003, when Saddam was overthrown and the president signed his supply-side tax cuts into law? (Bush, of course, never gets any credit on either of these points.)...
I have long believed that stock markets are the best barometer of the health, wealth and security of a nation. And today's stock market message is an unmistakable vote of confidence for the president.
As Kudlow wrote, the market was up a "remarkable" 30% over the previous year. As I write this, the market is up about 70% in the short 15 months since Obama took office.
But as I've long noticed, this phenomenon of measuring presidential competence by stock-market performance applies only to Republican presidents and Congresses. The LBJ economic boom, the Clinton economic boom, the stunning Obama economic turnaround - Dems get little credit on those points.
Now, I'm prepared to be surprised. For the sake of intellectual honesty, Kudlow might actually shed his reactionary tendencies long enough to note the current market's "unmistakable vote of confidence for the president." Paul Krugman provides a handy chart on his blog:
The Obama stock market. Hope you got in early. (Yahoo Finance)
Posted at 09:19 PM | Permalink | Comments (0)
I'm a progressive.
I'd be a liberal if the term still meant what it originally did, at its birth during the Age of Enlightenment. (The original name of the Lady in the Harbor was "Liberty Enlightening the World.") When, with John Locke figuring prominently as a philosophical touchstone, liberalism meant individual freedom, including speech and property rights. It meant the overturning of religious absolutism and monarchial and other autocratic regimes. It meant free trade and globalization in place of cloistered protectionism and isolationism. These liberal values were the driving force of the American and French revolutions.
But I don't recall having ever identified myself on this site as a liberal. The bastardization of "liberalism" reached its point of no return during the Great Society and other tumults of the 1960s. It became associated with "bleeding heart" welfarism (as opposed to a more constructive approach to realizing our moral obligation to helping our fellows in distress). With foreign policy naivete. With spendthrift administration of public funds. With trade-union supremacy over other stakeholders in the economy. And with personal irresponsibility.
About a third of the way into that paragraph, you thought, "Wait, that's the Right!" It's conservatives who have been spendthrift, naive on foreign policy (latest example, the Iraq war), who run roughshod over other stakeholders in the economy (Wall Street and corporate lobbyists), and go awry in their private lives as much as any identifiable group (Newt Gingrich, Mark Sanford, Bob Ney, the pedophiles in the Vatican's charge).
What today is a conservative, as I once identified myself? In Ontario, where the "Progressive Conservative Party" ruled for 43 consecutive years beginning during the Second World War, it meant no more government than necessary, but as much government as required. At the federal level, the Conservative Party subsidized construction of the transcontinental Canadian Pacific Railway and launched the CBC. In Ontario, the PCs built the province's network of community colleges and cultural assets such as the Ontario Science Centre and Ontario Place. They, and not the opposition Liberals, decided on full funding of Catholic schools, at the risk of alienating their base, because it was the right thing to do. They spent within their means, but they spent heavily, on social and physical infrastructure.
Classically, as in the Burke or Hobbes definition, conservatives are okay with progress - encourage it, even - as long as doesn't mean discarding hard-won lessons of the past. Such as living within your means and individual responsibility.
But conservatives in modern parlance are reluctant to assist those in distress, unless they're corporations in need of a taxpayer handout. They seem to oppose progress in the human condition utterly. (Example: the eight lost years in stem cell research when Dubya pandered to social conservatives in his base). They celebrate raw capitalism. Capitalism morphed into a "mixed economy" of government-private sector partnership in the 20th century. But it would appear that today's conservatives were behind the door during those history and economics lessons.
I don't think anyone can tell the precise meaning of today's "liberalism" and "conservatism." The only passably accurate term for me seems to be progressivism. The first U.S. president to embrace it by that name was a Republican, Teddy Roosevelt. For him, progressiveism meant breaking up the trusts that exerted too much power over the public. That's a recognizably "liberal" notion, as applied to, say, liberation from the tyranny of George III. And it meant protecting the public from peddlers of tainted meat and snake-oil cures. Hence the Food and Drug Administration, a TR legacy. Later it would be Richard Nixon to found the Environmental Protection Agency - and who thinks of him as a "liberal"?
Jefferson said, "That government governs best which governs least." That's easily a rallying cry for today's conservatives. Those like Grover Norquist, for example, who famously said his goal is to shrink government to a size where "you can drown it in a bathtub."
But the author of the Declaration wasn't calling for the eradication of government, least of all the one of which he was a prime architect. Jefferson was speaking a variation of my earlier reference to government when necessary, but not more government than necessary. It's the decision about the degree of government involvement that challenges us. Not, one hopes, the existence of government itself.
What libertarians have never grasped is that there will always be government. It will be government "by, of and for the people." The alternative is not solitude or chaos. Someone will be in charge. Someone will take charge. The alternative to what libertarians rail against is a military junta, an absolutist monarchy, a religious theocracy, a dynastic kleptocracy, an ideological imperium like Cuba or the Soviet Union or something equally disagreeable. Because wherever people gather, they promptly organize themselves. Or perhaps I misunderstand Golding's point in Lord of the Flies.
You'll get government, whether you like it or not. I'm for an accountable, pragmatic progressive government. My starting point is helping people in trouble, as much as possible on their terms. (Who knows the problem better than they?) And the larger project is a caring society. The alternative is gated communities, a throwback to a caste society in which opportunity is open only to the elect.
So, progressive. Easy to say, too. Same number of syllables as "liberal," one fewer than "conservative," four fewer than "Christian fundamentalist." A dynamic term for those who are optimistic about the future. Conservatives seem afraid of the future, a trait they do share with Burkeans, who fretted about unrestrained liberty evolving into mob rule. Rousseau, a liberal, trusted too much in the intelligence of our species. Burke, a classic conservative, deemed the people not quite sufficiently intelligent to act in their own best interests. And doesn't the latter sound familiar? It's akin to the patronizing "nanny state" regard for people of which conservatives accuse liberals. That's what I mean about today's muddled terminology.
"Call me anything but late for dinner" was the breezy assertion of my parents' generation. After fascism, communism, Marxist-Leninism, and failed, Depression-era capitalism, they were wary of isms and labels.
I don't want to be late, either. I don't want to be late for the 21st century. For the rebirth of cities. For unprecendented comity among nations and cultures. For an environmentally sustainable life for our species. And for a caring society, in which no one is alone in their grief, troubles, promise and challenges, except by choice.
That's progressivism to me.
(Illustration: Liberal Party of Canada poster, 1930. The Liberals lost that year's election, but governed for nearly 70 years in the 20th century. Source: National Archives of Canada)
Posted at 09:16 PM | Permalink | Comments (0)
Cast your mind back to 1993-94, as "the vast right-wing conspiracy" had an open field in de-legitimizing Bill Clinton's presidency.
Not this time.
By most definitions, a conspiracy is at least somewhat secretive, which the anti-progressive forces decidedly are not. But conspiracy has a nefarious connotation, accurate in this case of reactionaries at war with the truth. And what most characterizes a conspiracy is a network, in this case extensive, of like-minded agents.
Clinton's defenders were thin on the ground. And, with exceptions like James "Serpenthead" Carville, were not street fighters. (Barbra Streisand?) Al Franken and Michael Moore didn't really hit their stride until Dubya took the stage.
Maybe it's because the G.O.P. screwed up so vastly in 2001-09 - two recessions, a botched war of choice, failing to protect the homeland from 9/11 and the aftermath of Hurricane Katrina, doubling in eight years a national debt Bush Jr.'s 42 predecessors spent 224 years accumulating - but the MSM seems more inclined than in 1993-2001 to accommodate the views of those opposing this president's vilifiers.
And, equally important the progressives have come out of hiding hibernation, and are raising their game with considerable speed. Yes, there's Limbaugh, O'Reilly, et al. But there now are lacerators on the left, too - Maddow, Olberman and Rep. Alan Grayson, to name a few. Meanwhile, entertainers Tucker Carlson, Mona Charon, the Coultergeist have been around so long we've tuned them out.
Here's some progressive pushback of the past few hours:
* Paul Krugman calls G.O.P. "bailouts" claim "possibly the most dishonest argument ever made in the history of politics." Notice Krugman doesn't say "American" politics. So I guess he's including Berlusconi, Aethelred the Unready and Vlad the Impaler. (video; ABC's "This Week")
* Joe Klein of Time says statements by Beck, Palin are "right up close to being seditious." (video, "Chris Matthews Show")
* Andrew Sullivan, progresssive who blogs at the Atlantic, renews sedition charges against Beck, Palin and "the Fox News Republican National Committee Coaliton Machine." (video; "Chris Matthews Show")
* Joan Walsh: "Right now there is a climate of violence on the right." (video, CNN's "Reliable Sources")
Okay, Joe (Anonymous) Klein can be a weasel. But that makes my point. When this agent of conventional wisdom sides with the progressives...Well, its not like LBJ "losing" Cronkite, but it says something about growing MSM disgust with too many right-wing fabrications to ignore.
That's especially true when, as now, the falsehoods from the right are not counter-balanced by at least some responsible G.O.P. voices. This is the price Mitch McConnell and John Boehner are paying for strait-jacketing fellow Republicans. When your side speaks with one, bile-flecked voice, the MSM for the sake of variety alone is more inclined to give the other side a hearing - conspicuously not the case in 1993-2001.
That's not to say the right is failing with the wall of noise it puts up. Just that progressives are putting some cracks in it, and the Nov. 9, 1989 for progressives is in sight.
Posted at 08:03 PM | Permalink | Comments (3)
James Murdoch, 37, daddy's head of European and Asian ops, storms into newsroom of the redesigned Independent, one of London's half-dozen upmarket national dailies, livid about Independent ads hinting at Roop-media's political influence in the midst of the current U.K. national election campaign.
The U.K. Guardian reports:
In common with so many of the unpleasant episodes involving angry young men in modern London, it was a squall about reputation and respect. The newly relaunched Independent had produced a series of relatively innocuous promotional ads assuring readers: 'Rupert Murdoch won't decide this election. You will.'
There is no evidence that Murdoch senior has even seen the ads, but witnesses report that directly upon seeing Kelner, who was supervising the final production stages of that night's paper, Murdoch the younger began angry remonstrations. 'What are you fucking playing at?' was his opening gambit.
James Murdoch, cry baby. (Photo: WikiCommons)
Another case in which the apple doesn't fall far from the tree. My, what insecurity? Could this be the same family whose New York Post is editorializing that proposed congressional Wall Street reforms will destroy the Big Apple economy? (Uh, blockheads, an unrestrained Wall Street has impaired Gotham's economy. Wakey, wakey.) Whose Faux News maintains an alternative-reality force field on behalf of the right? Who can pass off sewage as news to the unsuspecting, but can't take an isolated tap on the knuckles?
Sheesh. James, 37, is no W.R. Hearst. But then, neither is Roop Sr.
Hearst actually believed in the American imperialism his yellow journalism stoked. By contrast, Roop means only to protect his financial interests. Murdoch Sr. aligned with Hillary Clinton in her New York Senate race and then, picking the wrong horse next time, flirted with her again for the Dem presidential nomination. Murdoch helped launch Margaret Thatcher, School-Milk Snatcher, who broke the Fleet Street unions for Roop. But he later backed a Labourite Tony Blair obviously about to topple the Tories. He shilled for Dubya, of course, and stoutly defends the Commie autocrats in Beijing. Roop just wants to be aligned with those holding power wherever he reaps his profits, or those poised to soon do so.
It's a bidness, as the late Molly Ivins would say. Too bad the collateral damage is civic hygiene.
Posted at 06:58 PM | Permalink | Comments (0)
The big show of the week:
Tuesday marks start to the showdown between Carl Levin's congressional committee and Wall Street. Lead-off star witness is Lloyd Blankfein, CEO of Goldman Sachs, shaping up as America's Public Enema #1, tagged last summer by investigative reporter Matt Tabbi in Rolling Stone as "a great vampire squid wrapped around the face of humanity." Blankfein says Goldman has been doing "God's work." Levin on the weekend released Goldman internal e-mails that show, he says, that Goldman was "betting against the U.S. housing market." That's not sexy enough. WH and Dems must cast Goldman and its Wall Street co-conspirators as "betting against America," as Frank Rich does here.
Goldman's Blankfein: Who ya gonna believe, me or your lying eyes? (Photo: AP)
To put you in the mood for this week's Levin-Blankfein smack-down, here's a gripping two-part Bill Moyers interview with the co-authors of the bestselling 13 Bankers, a ripping expose of Wall Street malevolent greed that triggered the Great Recession and the loss of more than 8 million U.S. jobs.
If I was God, two things I might do: One is to have Texas or some other government-hating state (they're all south of the Mason-Dixon line save Montana, Idaho and the Dakotas) do without government for a year and wait to see how long it takes them to gather up all their "Don't Mess With Texas" knick-knacks and dump them into the Gulf of Mexico. Texas, of course, began as a government project,stolen liberated on Texans' behalf from Mexico by Uncle Sam.
Second thing, I'd scramble every TV signal in America save PBS. That's right, nothing but PBS 24/7 for a year. The couch potatos and sports addicts would squawk, but since there's a Republic awaiting rebirth, the stakes are high enough to suspend Faux News, the Golf Channel and the Food Network for until next spring. I mean, isn't there a cookbook store on every corner by now?
Taliban fighters west of Kabul, April 4, 2009.
Heads-up 2: The Taliban is planning its own troop surge in what's shaping up as yet another failed foreign occupation of Afghanistan. (q.v. Britain, Soviet Union...)
March 4, 1970, four dead in Ohio, an iconic image of the tragedy of the Vietnam War. The dead, cut down by Ohio National Guardsmen with high-powered rifles, were Kent State students Jeff Miller, Allison Krause, Bill Schroeder and Sandra Scheuer (below). Scheurer was shot through the throat from 400 feet.
Sandra Scheuer, one of four unarmed students protesting the U.S. bombing of Cambodia gunned down by Ohio National Guardsmen on May 4, 1970. (Photo: Scheuer family)
Heads-up 3: A week this Tuesday, to mark the 40th anniversary of the tragedy at Kent State University, Michael Moore plans a live webcast of what he he's describing as a Kent State Truth Tribunal. Four students were killed that day by Ohio National Guardsmen, and nine more injured, and to this day no one has been held to account.
Now that Bush-Cheney axis of evil is gone, Jon Stewart makes Faux News his chief target. What "The Daily Show" reveals would be funny for its absurdity if it weren't, in fact, quasi-tragic, given Murdoch's huge audience of brainwashees. Which makes "The Daily Show" an indispensible tag team with Media Matters for America, a go-to source for falsehoods and distortions in the MSM.
"Stewart does a great job of using comedy to expose the tragedy that is Fox News, and he also underscores the seriousness of it," Eric Burns, president of Media Matters, tells the NYT. In its account, "Jon Stewart's Punching Bag, Fox News," the Times reports that:
[Stewart] said on the show this week that he criticizes the network a lot because it is 'truly a terrible, cynical, disengenuous news organization.'
Is Facebook to blame for a "girls crisis"? (Antonia Zerbesias, women's issues blogger, Toronto Star)
Shocker: A U.S. shrink, writing in NYT Magazine, describes how he's learned that spending a little more time than his usual 20 minutes with patients enables him to more accurately diagnose them and prescribe the right drugs. To read his account, he's part of whole generation of like-minded shrinks that somehow graduated med school to inflict drive-by psychiatry on the public all these years.
Posted at 05:41 PM | Permalink | Comments (0)
Senate panel to release damning documents on credit-rating agencies' role in financial meltdown. Without the seal of approval from S&P and Moody's, those toxic assets would never have been bought by suckers worldwide. (NYT)
Two mines show how safety practices vary widely in U.S. Some mines get workplace safety right. (NYT)
Why Romney should take credit as father of Obamacare. He pioneered it as Massachusetts governor. He's been running away from his record ever since, but shouldn't. (Newsweek)
America's demographic advantage. With its continued robust birth rate, America, already third-most-populous nation, will keep growing. (Joel Kotkin, Newsweek)
With a fertility rate 50 percent higher than Russia, Germany, or Japan, and well above that of China, Italy, Singapore, South Korea, and virtually all of Eastern Europe, the United States has become an outlier among its traditional competitors, all of whose populations are stagnant and seem destined to eventually decline. Thirty years ago, Russia constituted the core of a vast Soviet empire that was considerably more populous than the United States. Today, Russia's low birthrate and high mortality rate suggest that its population will drop by 30 percent by 2050, to less than one third that of the United States. Even Prime Minister Vladimir Putin has spoken of 'the serious threat of turning into a decaying nation'.
How the tax system is rigged to benefit the rich. I challenge you to read this and not have drops of blood start forming on your forehead. Here's a perfect example of how the presidency has gained power at the expense of Congress: administrations simply refuse to enforce the law. (Ezra Klein, Newsweek)
Every year the IRS collects data on "the tax gap." The tax gap is the difference between the taxes the agency knows it's owed and the taxes the agency has actually been paid. In fiscal year 2008, the tax gap was $345 billion. That's about 14 percent of the total taxes collected that year. And you know who makes up that shortfall: those of us who didn't dodge our taxes...
A report released by Citizens for Tax Justice shows that between 1995 and 2005, the IRS's budget was slashed by a fifth. Between 1995 and 2003, its enforcement division lost 36 percent of its staff. They were barred from conducting research on tax evasion, which meant they lost the ability to keep up with new tricks that accountants had discovered to game the tax code. More bizarrely, audits of the poor increased, through a special program meant to ferret out Earned Income Tax Credit fraud, but audits of people making more than $100,000 fell from 210,000 in 1996 to 92,000 in 2001—despite the fact that there were 80 percent more income filings over $100,000.
Posted at 02:05 PM | Permalink | Comments (0)
Some nice lines in Paul Krugman's column today:
Remember the 1987 movie Wall Street, in which Gordon Gekko declared: Greed is good? By today's standards, Gekko was a piker. In the years leading up to the 2008 crisis, the finacial industry accounted for a third of domestic profits - about twice its share two decades earlier.
Those profits were justified, we were told, because the industry was doing great things for the economy. It was channeling capital to productive uses; it was spreading risk; it was enhancing financial stability. None of those were true. Capital was channeled not to job-creating innovators, but into an unsustainable housing bubble; risk was concentrated, not spread; and when the housing bubble burst, the supposedly stable financial system imploded, with the worst global slump since the Great Deprerssion as collateral damage.
We've been devoting far too large a share of our wealth, far too much of the nation's talent, to the business of devising and peddling complex financial schemes - schemes that have a tendency to blow up the economy. Ending this state of affairs will hurt the financial industry. So?
But then there's this:
On Thursday, President Obama went to Manhattan, where he urged an audience drawn largely from Wall Street to back financial reform. "I believe," he declared, "that these reforms are, in the end, not only in the best interest of our country, but in the best interest of the financial sector."
Well, I wish he hadn't said that - and not just because he really needs, as a political matter, to take a populist stance, to put some public distance between himself and the bankers. The fact is that Mr. Obama should be trying to do what's right for the country - full stop. If doing so hurts the banks, that's O.K....
In his Thursday speech, by the way, Mr. Obama insisted - twice - that financial reform won't stifle innovation. Too bad.
Three times William Jennings Bryan sought the presidency as the Dem nominee, campaigning against Wall Street. Three times he lost.
It would be bad politics for Obama to incessantly beat on Wall Street. Americans, no fools, would see this as blaming someone else for challenges they expect their president to tackle without complaint. Of course there's populist rage out there at the banks and the bailouts. But the punditry exaggerates its breadth and potency, and discounts how this anger will dissipate in an economic recovery.
Obama has everything to gain from the even-handed, open-hearted effort he made yesterday to recruit Wall Street into the reform effort. It squares with the president's trademark reasonableness and his common-sense approach to problem-solving. It's in keeping with his ideology-free style, which appeals especially to the swelling ranks of independents.
As for stifling innovation, not all financial-markets innovation has been subprime, or junk, mortgages; credit default swaps; collateralized debt obligations; and special investment vehicles (for hiding dubious assets off the balance sheet). Automatic banking/teller machines are a financial-markets innovation. So are credit cards that enable you to accumulate points toward free or discounted purchases. So is drive-through branch banking and daily interest savings accounts.
As it happens, subprimes - which predate the housing boom - serve a useful purpose when marketing responsibly. Credit default swaps are an important device by which airlines hedge against a spike in fuel prices, and aluminum producers hedge against a slump in metal prices.
Now turn this on its head. The president says his plan is to stifle innovation. By which he means throwing the baby out with the bathwater, pardon the cliche. America thrives on innovation. It's as American as apple pie. (That cliche, too.) Everyone craves innovation - that is to say, progress - provided only that it doesn't harm anyone.
To appease Krugman, Obama might have qualified that remark by adding, "But with any innovation, we must test it using the doctor's oath: "First, do no harm."
It's okay to have a tin ear for politics. Indeed, it's essential that visionaries untether themselves from the status quo and the cries of "It can't be done," in order to conceive a better world.
But you notice we rarely put visionaires in charge. And that when we do, they generally fail. As a rule they have insufficient appreciation for the pragmatism required to get things done in the real world.
Ideally our leaders sup with visionaries, and apply their public-arena skills to turn a vision into the world's longest bridge of its kind and time spanning the East River connecting Brookyn with Manhattan. To explore the heavens with spacecraft rather than mere telescopes. And to create and strengthen a social safety net that does not bust the budget or drain the taxpayer of an inordinate amount of disposable income.
I guess this is the conservative side of my personality, the part that asks, "Where will you get the money?" "How will you overcome the inevitable opposition?" "Are you sure this new thing will work, when the current thing seems to work well enough?" All three of those questions were deeply felt by Americans during the HCR debate. And HCR almost perished for its advocates' sloth in getting around to ackowledging them.
Krugman is one of those folks, like Robert Reich and Joseph Stiglitz and Robert Scherr, who are on the right side of history. God bless 'em. They are required reading.
Reich wants to break up the banks so none has more than $100 billion in assets. If other nations fail to follow suit, America's resulting puny banks would be eaten alive by their giant offshore rivals. But I get the principle, that size for its own sake is the philosophy of the cancer cell. And, as GM proved, in time it becomes impossible to manage. But size has its obvious advantages. Can we focus on making size work, rather than revert to the small-is-beautiful notions of the 1960s?
I just have to confess I'd find the ideas of my progressive heroes a tad easier to wholly embrace if they were a bit more grounded in practicality. Not a lot, just a bit.
Nitpick: I mean no slight of Krugman, everyone does it: What Michael Douglas' character actually says is, "Greed, for lack of a better word, is good." The nuance is important. Even Gekko acknowledges that his pro-avarice philosophy is in some ways indefensible.
(Photo: New York Times handout)
Posted at 01:44 PM | Permalink | Comments (0)
Obama at Cooper Union yesterday, on his proposed financial-markets reforms:
Unless your business model depends on bilking people, there is little to fear from these new rules.
Posted at 12:54 PM | Permalink | Comments (0)
David Olive is a business and current affairs columnist at the Star, which he joined in 2001 after stints at the Globe and Mail, National Post and Financial Post.
"If all economists were laid end to end, they would not reach a conclusion."
- George Bernard Shaw


text:
Mar 15, 2009 Table of Contents
Diagnosis and Management of Sjögren Syndrome
Am Fam Physician. 2009 Mar 15;79(6):465-470.
Patient information: See related handout on Sjögren syndrome, written by the authors of this article.
Sjögren syndrome is a systemic autoimmune disease characterized by dry eyes and dry mouth. Other organ systems are affected in many patients. Sjögren syndrome is classified as primary or secondary. In primary disease, Sjögren syndrome is a solitary process, whereas secondary disease accompanies another autoimmune disease—often rheumatoid arthritis. Sjögren syndrome is a challenging diagnosis, requiring the family physician to coordinate with a team of specialists, including dentists, otolaryngologists, rheumatologists, and ophthalmologists. Pilocarpine and cevimeline can help relieve dry eyes and dry mouth.
Sjögren syndrome is one of the three most common systemic autoimmune diseases.1 As many as 1 to 2 million persons in the United states are affected ; the reported prevalence is between 0.05 and 4.8 percent of the population.3 A study from Olmsted County, Minn., estimated the incidence of physician-diagnosed primary Sjögren syndrome to be about four cases per 100,000 persons.3
Primary Sjögren syndrome mainly affects middle-age women. In a cohort of 400 persons with Sjögren syndrome, 93 percent were women, and the mean age at onset of symptoms was 52.7 years.4
Clinical recommendation | Evidence rating | References |
The muscarinic agonists pilocarpine (Salagen) and cevimeline (Evoxac) can be used to relieve xerophthalmia in patients with Sjögren syndrome. |
Muscarinic agonists improve subjective and objective signs and symptoms of xerostomia in patients with Sjögren syndrome. |
Interferon alfa improves subjective oral and ocular dryness and increases nonstimulated saliva flow in patients with Sjögren syndrome. |
A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to http://www.aafp.org/afpsort.xml.
The pathogenesis of Sjögren syndrome is obscure.1 It is probably the result of an environmental stimulus that promotes an auto-immune reaction in genetically susceptible persons. Infectious agents—most commonly sialotropic viruses—have been postulated to trigger the syndrome; however, associations with most of the potential viral candidates, including cytomegalovirus and Epstein-Barr virus, are weak.5 Serologic studies show an association between primary Sjögren syndrome and HLA-DR haplotypes.6
Sjögren syndrome represents a complex, multifaceted activation of the immune system. B-lymphocyte dysregulation and hyper-activity play a major role in the disease. The histological hallmark of Sjögren syndrome is lymphocytic infiltration of the exocrine glands, which leads to acinar gland degeneration, necrosis, atrophy, and decreasing lacrimosalivary function.7 Glandular neurodegeneration is also present, which may explain why patients experience sicca syndrome when more than 50 percent of the glandular epithelial cells remain intact.8
Typical Presentation
Sjögren syndrome typically presents as dry eyes and dry mouth, also referred to as xerophthalmia (or keratoconjunctivitis sicca [KCS]) and xerostomia, respectively. In a large prospective cohort study of 400 patients with Sjögren syndrome, 98 percent presented with xerostomia, and 93 percent with xerophthalmia.4 Eye symptoms include dryness, grittiness, pruritus, and foreign body sensation. Oral symptoms include difficulty speaking, eating, or swallowing, and frequent sips of water may be needed.
On physical examination, the patient's eye may show conjunctival injection because there may be ocular inflammation independent of lacrimal gland involvement. In more severe cases, clouding of the cornea may be seen.9 Early oral findings include decreased salivary pool and dry mucous membranes, which can progress to erythema, fissuring, and ulceration.9 The patient may also have multiple dental caries as a result of decreased salivary flow; saliva prevents dental caries by promoting dental remineralization, providing antimicrobial activity against cariogenic bacteria, and maintaining a physiologic oral pH level.10 Parotid glands may be tender or swollen. Other causes of enlarged parotid glands include acute suppurative sialadenitis, mumps, tuberculosis, sarcoidosis, and lymphoma.11
Patients also may present with extraglandular symptoms (Table 1).4,12
Table 1. Extraglandular Manifestations of Sjögren Syndrome
Extraglandular Manifestations of Sjögren Syndrome
Clinical signs and symptoms | Frequency (%) |
Arthralgia or nonerosive arthritis characterized by tenderness, swelling, or effusion of peripheral joints |
37 to 75 |
Gastrointestinal symptoms (reflux, dyspepsia, diarrhea, constipation) |
54 |
Autoimmune thyroiditis |
15 to 33 |
Pulmonary disease (chronic cough, recurrent bronchitis with chronic diffuse interstitial infiltrates on radiography, abnormal spirometry, pulmonary alveolitis or fibrosis on computed tomography) |
29 |
Raynaud's phenomenon |
16 to 28 |
Cutaneous vasculitis |
12 |
Peripheral neuropathy |
7 |
Lymphadenopathy (enlarged lymph nodes in cervical, axillary, or inguinal region) |
7 |
Renal involvement (proteinuria, renal tubular acidosis, interstitial nephritis, glomerulonephritis, abnormal urinalysis) |
6 |
Fever not associated with infectious process |
6 |
The diagnosis of primary Sjögren syndrome is strongly suggested in patients who present with signs and symptoms of oral and ocular dryness and who test positive for antibodies to the anti-SS-A or anti-SS-B antigen, or who have a positive salivary gland biopsy.1 Table 2 lists the frequency of positive results for common laboratory tests in Sjögren syndrome.2–4,9 It should be noted that antibodies to the anti-SS-A and anti-SS-B antigens are not specific to Sjögren syndrome; they may be present in persons with other diseases (e.g., lupus) and in healthy persons.
Table 2. Frequency of Positive Laboratory Test Results in Primary Sjögren Syndrome
Sjögren syndrome often has an insidious onset, a variable course, and a wide spectrum of clinical manifestations, making the diagnosis difficult or delayed.2,13 Early recognition of Sjögren syndrome may prevent complications such as dental caries, corneal ulceration, chronic oral infection, and sialadenitis, and it allows for clinical surveillance for the development of serious extraglandular systemic manifestations.13
Aside from xerostomia and KCS, which are nonspecific, Sjögren syndrome lacks a single distinguishing feature and is identified by a combination of clinical manifestations and laboratory findings.14 The most recent criteria for classification of Sjögren syndrome requires a positive minor salivary gland biopsy or a positive anti-SS-A or anti-SS-B antigen test (Table 3).15 These criteria were not designed for diagnosis, but for establishing homogeneity of research cohorts. However, they provide a useful framework to make a diagnosis.
Table 3. Revised International Classification Criteria for Sjögren Syndrome
Revised International Classification Criteria for Sjögren Syndrome
note: The classification requires four of the six items, one of which must be a positive minor salivary gland biopsy or a positive antibody test, or the presence of three of the four objective items (items 3, 4, 5, and 6).
Adapted with permission from Vitali C, Bombadieri S, Jonsson S, et al., for the European Study Group on Classification Criteria for Sjögren's Syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61(6):557.
Table 4 lists the differential diagnosis of xerophthalmia and xerostomia, and their distinguishing clinical features.1,9,10,16–18
Table 4. Differential Diagnosis of Dry Eyes and Dry Mouth
Differential Diagnosis of Dry Eyes and Dry Mouth
Condition | Comment |
Causes of dry eyes | |
Allergic conjunctivitis |
Burning eyes, mucoid secretion, and conjunctival erythema |
Blepharitis |
Eyelid margins are erythematous and thickened with crusts and debris within the lashes; usually worse in the morning and improves as the day goes on; does not respond to lubricant drops |
Environment |
Dryness caused by prolonged exposure to low humidity, dust, or sun |
Lifestyle |
Dryness caused by diminished blinking during long periods of reading, driving, or computer use |
Medications |
Diuretics and anticholinergic medications, including treatments for Parkinson disease, Alzheimer disease, depression, allergic rhinitis, and incontinence |
Rosacea |
Ocular symptoms (e.g., itchy, burning, dry eyes with eyelid swelling and erythema) occur in 50 percent of patients with rosacea |
Causes of dry mouth | |
Diabetes |
Dryness worsens with poor glycemic control |
Head and neck radiation |
External beam radiation damages salivary glands |
Hepatitis C |
Sialadenitis results in dry mouth in 15 percent of persons with hepatitis C |
HIV infection |
HIV-related salivary gland disease exhibits clinical manifestations similar to Sjögren syndrome |
Medications |
Diuretics and anticholinergic medications, including treatments for Parkinson disease, Alzheimer disease, depression, allergic rhinitis, and incontinence |
Obstructed nasal passages |
Dryness caused by mouth breathing |
Sarcoidosis |
Decreased salivary flow results from noncaseating granulomas in salivary glands |
Although the diagnosis of Sjögren syndrome may be suggested by the patient history and physical examination, there are multiple objective tests to help with the diagnosis. These tests are not commonly performed in the family physician's office.
Eye symptoms are usually evaluated with the Schirmer test or the rose bengal test. The Schirmer test involves placing a sterile filter paper strip beneath the lower eyelid for five minutes. If the moistened area measures less than 5 mm, the test is positive.2 The rose bengal test usually is performed by an ophthalmologist; 1% rose bengal dye is instilled and the ocular surface integrity is evaluated by quantitatively scoring the staining of the conjunctiva.19 Rose bengal dye will stain devitalized corneal and conjunctival epithelial cells. The test will identify KCS when minimal ocular symptoms are present.9 A routine slit-lamp evaluation can identify a diminished tear meniscus.9
Oral dryness can be evaluated objectively by nonstimulated whole saliva flow collection, in which the patient spits into a graduated test tube every minute for 15 minutes. Collection of less than 1.5 mL in 15 minutes is considered a positive result.14 Other tests include contrast sialography, which visualizes the salivary glands and ducts via contrast dye injection into the Stensen duct, and scintigraphy, which evaluates salivary gland function by measuring sequential uptake and excretion of technetium 99m.10
Although once considered the gold standard for diagnosis of Sjögren syndrome, minor salivary gland biopsy of tissue taken from the patient's lip is not always necessary.13 A positive biopsy is defined as at least one focus of dense, inflammatory infiltrate containing at least 50 lymphocytes per 4 mm2.9 The lip biopsy may be useful in ambiguous cases or when therapy beyond symptom management is being considered.
Because there is no known cure for Sjögren syndrome, treatment focuses on relieving symptoms and preventing complications. Treatments can be grouped into regimens for KCS, xerostomia, and systemic manifestations.
Ocular treatment begins with topical tear replacement. Development of a solution that completely simulates human tears, with all of their complex constituents, has not yet been achieved.20 Preservative-free artificial tears are tolerated better than solutions with preservatives.
If artificial tears do not satisfactorily relieve symptoms, the next step is increasing tear production by stimulating muscarinic receptors, which are a type of cholinergic receptor found on exocrine glands, heart muscle, and smooth muscle. Several randomized trials have shown two muscarinic agonists, pilocarpine (Salagen) and cevimeline (Evoxac), to be effective.21,22 Pilocarpine is a nonselective muscarinic agonist, whereas cevimeline is a selective muscarinic agonist that reportedly has less effect on cardiac and lung tissues.23 Oral pilocarpine, at a dosage of 5 mg twice daily, has been shown in a small randomized control trial (RCT) to decrease subjective eye symptoms and improve results of rose bengal testing.21 Oral cevimeline, at a dosage of 30 mg three times daily, relieved subjective eye symptoms in another small RCT.22 Muscarinic agonists are contraindicated in angle-closure glaucoma and uncontrolled asthma. Other topical anti-inflammatory medications, such as steroids and cyclosporine (Neoral), are of questionable benefit.20
Treatment for xerostomia consists of good oral hygiene, salivary stimulation, use of saliva substitutes, and recognition of complications. Xerostomia increases the risk for dental caries and oral infections. Daily topical fluoride use and antimicrobial mouth rinses can help prevent caries in patients with reduced salivary flow.23 Sugar-free chewing gums and sour lemon lozenges may be used for salivary stimulation. Xylitol, a naturally occurring sugar substitute, has been shown to decrease dental caries when used in chewing gum in the general population.24 Several over-the-counter salivary substitutes are available as lozenges, rinses, sprays, and swabs. They contain carboxymethylcellulose, mucin, or glycerine, which help lubricate the oral mucosa. Muscarinic agonists also may be used. An RCT of 44 patients showed that pilocarpine at a dosage of 5 mg four times daily is superior to placebo in improving subjective xerostomia.25 Another small RCT showed that cevimeline at a dosage of 30 mg three times daily improves xerostomia symptoms and salivary flow.26
Although pilocarpine and cevimeline have been shown to reduce symptomatic oral dryness and to produce transient increases in salivary flow, neither drug addresses the underlying disease process or leads to increases in basal nonstimulated salivary flow.27 Systemic and biologic agents are being investigated for use in Sjögren syndrome. A study on interferon alfa, an immunomodulator, showed an improvement in subjective oral and ocular dryness and an increase in nonstimulated whole saliva flow.7 A smaller study showed improvement in histologically normal-appearing minor salivary gland lip biopsies in patients treated with oral interferon alfa.27 Trials of tumor necrosis factor antagonists have shown varied results. The largest trial of these agents showed no improvement in oral dryness, ocular dryness, or objective tests, including the Schirmer test and focus score on labial salivary gland biopsy.8 In this study, 103 patients were randomized to infliximab (Remicade) infusions or placebo and evaluated at 10 and 22 weeks.
Antimalarial medications and corticosteroids are being re-evaluated in the treatment of Sjögren syndrome.28 Hydroxychloroquine (Plaquenil) may be useful for treating the arthralgias and fatigue associated with Sjögren syndrome. Rituximab (Rituxan), an anti-CD20 monoclonal antibody that depletes B lymphocytes, holds promise as a therapy for severe inflammatory manifestations of Sjögren syndrome.28
The most serious complication associated with primary Sjögren syndrome is the development of a lymphoproliferative disease, primarily non-Hodgkin lymphoma. Multiple studies have shown an increase in the risk of lymphoproliferative disease, but no increase in all-cause mortality.29–31 In contrast with primary Sjögren syndrome, other rheumatologic diseases, including lupus, rheumatoid arthritis, and scleroderma, have been associated with increased mortality rates.29 The risk of lymphoma in patients with primary Sjögren syndrome is 40 times that of the general population.1 A prospective study of 484 Swedish patients showed that lymphoproliferative diseases caused six of 34 deaths (18 percent) in the seven years of follow-up, with an average age of 75 years at the time of death.29 However, this study did not show an increase in rates of all-cause mortality in persons with primary Sjögren syndrome compared with the general population.29 A larger cohort study of 723 Greek patients with 4,384 person-years of follow-up found that seven of 39 deaths (18 percent) were caused by lymphoma.31 A total of 30 cases of lymphoma were recorded, with an average follow-up of six years.
Multiple studies have shown that low levels of complement protein C3 or C4 at the time of diagnosis are associated with a higher rate of lymphoproliferative disease and a higher mortality rate.29,31–34 In addition to hypocomplementemia, vasculitis and severe involvement in parotid scintigraphy have been linked to lower survival rates.34
Although there is no definitive evidence to support screening guidelines for lymphoproliferative diseases in patients with Sjögren syndrome, the following features should raise the physician's index of suspicion: enlarged parotid glands, regional or general lymphadenopathy, hepatosplenomegaly, pulmonary infiltrates, vasculitis, and hypergammaglobulinemia.1
1. Fox RI. Sjögren's syndrome. Lancet. 2005;366(9482):321–331.
2. Sánchez-Guerrero J, Pérez-Dosal MR, Cárdenas-Velázquez F, et al. Prevalence of Sjögren's syndrome in ambulatory patients according to the American-European Consensus Group criteria. Rheumatology (Oxford). 2005;44(2):235–240.
3. Pillemer SR, Matteson EL, Jacobsson LT, et al. Incidence of physician-diagnosed primary Sjögren syndrome in residents of Olmsted County, Minnesota. Mayo Clin Proc. 2001;76(6):593–599.
4. García-Carrasco M, Ramos-Casals M, Rosas J, et al. Primary Sjögren syndrome: clinical and immunologic disease patterns in a cohort of 400 patients. Medicine (Baltimore). 2002;81(4):270–280.
5. Hansen A, Lipsky PE, Dörner T. Immunopathogenesis of primary Sjögren's syndrome: implications for disease management and therapy. Curr Opin Rheumatol. 2005;17(5):558–565.
6. Tzioufas AG, Wassmuth R, Dafni UG, et al. Clinical, immunological, and immunogenetic aspects of auto-antibody production against Ro/SSA, La/SSB and their linear epitopes in primary Sjögren's syndrome (pSS): a European multicentre study. Ann Rheum Dis. 2002;61(5):398–404.
7. Cummins MJ, Papas A, Kammer GM, Fox PC. Treatment of primary Sjögren's syndrome with low-dose human interferon alfa administered by the oromucosal route: combined phase III results. Arthritis Rheum. 2003;49(4):585–593.
8. Mariette X, Ravaud P, Steinfeld S, et al. Inefficacy of infliximab in primary Sjögren's syndrome: results of the randomized, controlled Trial of Remicade in Primary Sjögren's Syndrome (TRIPSS). Arthritis Rheum. 2004;50(4):1270–1276.
9. Vivino FB, Katz WA. Sjogren's syndrome: clinical picture and diagnostic tests. J Musc Med. 1995;12(3):40–52.
10. al-Hashimi I. The management of Sjögren's syndrome in dental practice. J Am Dent Assoc. 2001;132(10):1409–1417.
11. Ovchinsky A, Har-El G. Salivary gland enlargementLucent FE. Essentials of Otolaryngology. 5th ed. Philadelphia, Pa.: : Lippincott Williams & Wilkins; 2003:223–226.
12. Al-Hashimi I, Khuder S, Haghighat N, Zipp M. Frequency and predictive value of the clinical manifestations in Sjögren's syndrome. J Oral Pathol Med. 2001;30(1):1–6.
13. Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjögren's syndrome. Arch Intern Med. 2004;164(12):1275–1284.
14. Pertovaara M, Korpela M, Uusitalo H, et al. Clinical follow up study of 87 patients with sicca symptoms (dryness of eyes or mouth, or both). Ann Rheum Dis. 1999;58(7):423–427.
15. Vitali C, Bombadieri S, Jonsson S, et al., for the European Study Group on Classification Criteria for Sjögren's Syndrome. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61(6):554–558.
16. Fox RI, Stern M, Michelson P. Update in Sjögren syndrome. Curr Opin Rheumatol. 2000;12(5):391–398.
17. Carter SR. Eyelid disorders: diagnosis and management. Am Fam Physician. 1998;57(11):2695–2702.
18. Sreebny LM, Yu A, Green A, Valdini A. Xerostomia in diabetes mellitus. Diabetes Care. 1992;15(7):900–904.
19. Kim J. The use of vital dyes in corneal disease. Curr Opin Ophthalmol. 2000;11(4):241–247.
20. Whitcher JP. The treatment of dry eyes. Br J Ophthalmol. 2004;88(5):603–604.
21. Tsifetaki N, Kitsos G, Paschides CA, et al. Oral pilocarpine for the treatment of ocular symptoms in patients with Sjögren's syndrome: a randomised 12 week controlled study. Ann Rheum Dis. 2003;62(12):1204–1207.
22. Ono M, Takamura E, Shinozaki K, et al. Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study. Am J Ophthalmol. 2004;138(1):6–17.
23. Ship JA. Diagnosing, managing, and preventing salivary gland disorders. Oral Dis. 2002;8(2):77–89.
24. Burt BA. The use of sorbitol- and xylitol-sweetened chewing gum in caries control [published correction appears in J Am Dent Assoc. 2006;137(4):447]. J Am Dent Assoc. 2006;137(2):190–196.
25. Wu CH, Hsieh SC, Lee KL, Li KJ, Lu MC, Yu CL. Pilocarpine hydrochloride for the treatment of xerostomia in patients with Sjögren's syndrome in Taiwan—a double-blind, placebo-controlled trial. J Formos Med Assoc. 2006;105(10):796–803.
26. Fife RS, Chase WF, Dore RK, et al. Cevimeline for the treatment of xerostomia in patient's with Sjögren syndrome: a randomized trial. Arch Intern Med. 2002;162(11):1293–1300.
27. Shiozawa S, Tanaka Y, Shiozawa K. Single-blinded controlled trial of low-dose oral IFN-alpha for the treatment of xerostomia in patients with Sjögren's syndrome. J Interferon Cytokine Res. 1998;18(4):255–262.
28. Ramos-Casals M, Tzioufas AG, Font J. Primary Sjögren's syndrome: new clinical and therapeutic concepts. Ann Rheum Dis. 2005;64(3):347–354.
29. Theander E, Manthorpe R, Jacobsson LT. Mortality and causes of death in primary Sjögren's syndrome: a prospective cohort study. Arthritis Rheum. 2004;50(4):1262–1269.
30. Zintzaras E, Voulgarelis M, Moutsopoulos HM. The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch Intern Med. 2005;165(20):2337–2344.
31. Ioannidis JP, Vassiliou VA, Moutsopoulos HM. Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjögren's syndrome. Arthritis Rheum. 2002;46(3):741–747.
32. Ramos-Casals M, Brito-Zerón P, Yagüe J, et al. Hypo-complementaemia as an immunological marker of morbidity and mortality in patients with primary Sjögren's syndrome. Rheumatology (Oxford). 2005;44(1):89–94.
33. Skopouli FN, Dafni U, Ioannidis JP, Moutsopouls HM. Clinical evolution, and morbidity and mortality of primary Sjögren's syndrome. Semin Arthritis Rheum. 2000;29(5):296–304.
34. Brito-Zerón P, Ramos-Casals M, Bove A, Sentis J, Font J. Predicting adverse outcomes in primary Sjögren's syndrome: identification of prognostic factors. Rheumatology (Oxford). 2007;46(8):1359–1362.
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Millett 1" Angle-Loc Detachable Rings Weaver-Style Matte High
Product #: 125534
Millett #:
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Product Information
Millett Angle-Loc Detachable Rings are designed for use with a Weaver-style base. These rings have all excess weight removed to provide a slim ring that will look great on any rifle. The Angle-Loc mounting system provides a rock solid mount, and the rings can be removed with the included Allen wrench or a coin.
Technical Information
Material: Aluminum
Style: Weaver (cross-slot)
Ring Diameter: 1"
Ring Height: .470" (measured from base of ring to bottom of scope tube)
Technical Information
Material: Aluminum
Style: Weaver (cross-slot)
Ring Diameter: 1"
Ring Height: .470" (measured from base of ring to bottom of scope tube)
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The new Apple's Safari 3.1 browser is going to include some neat features for consumers. The main one is that Safari will be able to render non-standard fonts, which will allow rendering of more dynamic and customizable pages for the iPhone. Also with transform feature one can scale, rotate, skew and translate HTML boxes in real time, where developers allow for such actions.
Animations offer Ajax-like effects like fading out an HTML element without the need for it. Safari 3.1 will also support HTML5's SQL API. HTML5 will also permit for video and audio tags. This will support embedding video and audio content and playback controls in web pages.
The browser is in beta stages now, but it will be available for both Mac and PC.


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The Nokia N8 is powered by an ARM11 680 MHz processor combined with 3D Graphics HW Accelerator OpenGL-ES 2.0 support and Symbian^3 operating system. The Nokia N8 features: 3.5″ 16:9 nHD (640 x 360 pixels) AMOLED with 16.7 million colours screen display; 16 GB internal memory with up to 32 GB MicroSD memory card slot (hot swappable); 12 megapixel camera with Carl Zeiss optics; HD quality 720p resolution video cameras; BL-4D 1200 mAh Li-Ion battery (720 mins max. talktime for GSM and 350 mins max. talktime for CDMA).
The following manual provides information regarding operating instruction, user guide, menus, tools, setup, setting and resetting procedures for the Nokia N8 mobile phone series. The Nokia N8 manual is divided into sections as follows:
Get Started
Install Ovi Suite on Your PC
Touch Screen Actions
Interactive Home Screen Elements
Call a Phone Number
Save Phone Numbers and Mail Address
Send a Message
Social Networks
Take a Picture
Upload a picture or video to a service
View your pictures and videos on a TV
Connect a USB mass storage device
Back up files
Find more help
Access codes
Green Tips
Product and safety information
Get and download the Nokia N8 Manual, User Guide, Operating Instruction, Installation and Setting procedures here [free download PDF file manual from fjallfoss.fcc.gov]
- nokia n8 manual,nokia c70,nokia n8 instructions,nokia n8 instruction manual,nokia n8 operating manual,


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LMPSR 1.1 PARENTING SEMINARS A. The parents, petitioners, and respondents shall complete a parenting seminar approved by the Court in all cases filed under RCW Chapters 26.09, 26.10, and 26.26, which require a parenting or residential plan or custody order for minor children, including marital dissolutions, legal separations, paternity residential plans, non-parent custody actions, any action where one or both of the parties is under the age of eighteen (18) years, and any action in which the Court makes a discretionary finding that a parenting seminar would be in the best interest of the children. The Court may also order additional persons involved in the parenting of the minor children to attend the parenting seminar. B. Major Modifications of Parenting/Residential Plans or Custody Orders: All parents, petitioners, and respondents involved in a major modification of a parenting or residential plan or custody order need to have attended the parenting seminar at least once since the original case was filed before the court will enter modified parenting or residential plans or custody orders. A copy of the attendance certificate shall be filed with the Clerk of the Court. [Adopted effective September 1, 1995; Amended effective September 1, 2007] Click here to view in a PDF. |
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A collection of news and information related to Alan Alda published by this site and its partners.
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Displaying items 78-88
New ABC comedy to help channel 'Man Up!'
Now showing at new Emmys site: 600 in-depth video chats with TV legends
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Story | Nov 3, 2009 | 9:33 PMSteve Martin and Alec Baldwin are good, solid choices to host the Oscars, but it's hard to make sense of why they were tapped â and combined as a pair. Lately, Oscar chiefs have seemed eager to lure younger viewers and add song-and-dance entertainment... -
Obama, the night the stars came out
Blog | Dec 7, 2009 | 4:24 PMby Mark Silva First Lady Michelle Obama sat next to "the Boss'' last night. Seated on her other side at the John F. Kennedy Center for the Performing Arts in Washington was the president of the United States, there to...... -
Justin Timberlake makes history as first 'SNL' host to win Emmy
Story | Sep 17, 2009 | 8:53 AMSix-time Grammy champ Justin Timberlake added a second Emmy to his shelf with his win as guest actor in a comedy series for hosting "Saturday Night Live." In the first year that "SNL" hosts could contend for guest performer, Timberlake was the only one of... -
The Morning Fix: Kanye's Chaos; More Leno analysis (sigh); Tyler Perry still strong; Miley's voice mail
Story | Sep 17, 2009 | 8:53 AMAfter the coffee. Before that pitch call with Kanye West and Taylor Swift. Here's Jay! Tonight marks (finally) the debut of Jay Leno's prime time show and there is no shortage of analysis (or promos from the Peacock) on what...... -
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Story | Oct 22, 2009 | 4:34 PMShe was a woman who ''moved mountains in those Manolos'' -- one of the many words of praise Carol Biondi had to say about her old friend Nancy Daly at a memorial celebration on Wednesday evening. Hundreds of people filed into Royce Hall to honor Nancy's... -
Gold Derby nuggets: Jude Law loses 'Hamlet' duel | '24' brings back evil ex-prez | Roger Friedman: Grammys field fallow
Story | Nov 2, 2009 | 4:33 PM⢠The long lists for the Evening Standard theater kudos saluting the best of London's West End have been released. Jude Law was snubbed for his "Hamlet" at the Donmar Warehouse, but "Doctor Who" star David Tennant earned a nod for playing the desolate... -
VIDEO: 'Nothing But the Truth's Kate Beckinsale and Alan Alda Q&A


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Jocelyn Adams's Reading Interests
Stephen King, Laurel K. Hamilton, Charlaine Harris
About Jocelyn
Jocelyn Adams is an author and lover of fantasy stories, a wife, mother and former I.T. geek.
Some of her short stories will be published in 2011, in Residential Aliens Magazine, Hall Brothers Villainy anthology, Winter Canons anthology, Roar and Thunder...


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Wednesday, August 29, 2012 - Page updated at 10:30 p.m.Virginia Beach reveals arena plan | NBA
Virginia Beach reveals plan
Economic-development officials in Virginia Beach revealed a plan Tuesday to build a $350 million arena and attract an NBA or NHL team to Virginia's largest city, The Associated Press reported.
Virginia Beach officials said an 18,500-seat arena could be ready to house an NBA or NHL team by 2015.
There has been speculation the city has targeted the NBA Sacramento Kings, but a Sacramento Bee report noted officials "didn't mention any potential sports teams as tenants." The arena proposal is for a public-private partnership involving Virginia Beach and investors Comcast-Spectacor and Live Nation.
Asked whether his company has had discussions with Kings officials, Comcast-Spectacor President Peter Luukko said, "We have not had any talks."
Other cities that have been mentioned in speculation about Kings relocation include Seattle; Anaheim, Calif.; San Jose, Calif.; Kansas City, Mo.; Louisville, Ky.; Tampa, Fla.; and Las Vegas.
Weiss to join Hawks' staff
Former Hawks coach Bob Weiss is returning to Atlanta as an assistant coach and consultant on coach Larry Drew's staff. Weiss, 70, has coached four NBA teams, including the Sonics.
College football
Penn St. group is unhappy
A group of 29 past chairs of the Penn State faculty senate blasted the NCAA and former FBI director Louis Freeh over their handling of the Jerry Sandusky child sex-abuse scandal, saying Freeh's report — prepared for the university — and the NCAA's $60 million in fines unfairly punish the entire university community.
• Madison police arrested three 21-year-olds from Madison allegedly involved in the Aug. 1 assault on Wisconsin senior tailback Montee Ball.
Wendell J. Venerable, Deonte J. Wilson and Robert A. Wilks were taken into custody.
• Roneeka Hodges scored 20 points as the Tulsa Shock beat the host Atlanta Dream 84-80.
The Dream played without WNBA scoring leader Angel McCoughtry, who was suspended indefinitely for allegedly violating team rules.
In other WNBA games, league-leading Minnesota beat visiting San Antonio 96-84 in overtime; Connecticut won 83-72 at Chicago, and host Indiana defeated Washington 83-68.
• The NHL issued a new proposal to the players' association as a lockout looms next month. The sides will meet again Wednesday in New York.
• German cyclist John Degenkolb of the Argos-Shimano team won the 10th stage of the Spanish Vuelta, and Spaniard Joaquin Rodriguez of the Katusha team leads the 21-stage event.
• Art Heyman, an ex-Duke standout who played six seasons of pro basketball in the NBA or American Basketball Association, died Monday at 71.
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I've never heard of aluminium valve seats, they always have an insert of some type, don't think brass is the norm either.
Aluminium should be ok for pistons though, that's what they are in most engines.
i noticed most people seem to use brass or something for valve seats, the aluminum on a head made of 6061 t6 will not work? i plan on building a v8 to put in my 6ft long remote controlled boat. second will pistons made of 6061 hold up?
I've never heard of aluminium valve seats, they always have an insert of some type, don't think brass is the norm either.
Aluminium should be ok for pistons though, that's what they are in most engines.
Common "real" piston, piston alloys: 4043 or 2018, either are most commonly used in forgings.
Hypereutic alloys are now being used in some rare forgings and, more commonly, castings, especially 2 cycles.
Hypereutectic alloys are harder to machine (diamond tooling required) but have better hot strength due to additional silicon.
Typical valve seats: ductile iron, silicon bronze or straight cast iron.
You might get away with 2024 aluminum for pistons and/or or head but that depends on how much heat you generate.
Some guys machine the seats into aluminium heads and it works for running "display" type engines but I doubt it's a good bet for a "perfomance" engine like one you would like to build to run in a RC boat.
I wish it wouldn't crash.
It is the 'something' and almost certainly Stellite if you have seen valve seats that had a brass type appearance. Very hard high melting point alloy that I think can be called a bronze. Interesting stuff, I seem to remember you can get Stellite rods that look, feel and work just like bronze welding rods but once they have been melted and re-solidified the properties change so it is very hard and has a higher melting temperature than the first time.
- Stellite Typical Applications:
- Aerospace= vane plugs, fuel metering pins, spacer bushings.
- Bearings= ball blanks and race blanks
- Valve Seat Inserts= duesel engine exhaust and fluid valve seats
- Saw cutter inserts
- Miscellaneous wear parts
Hi there,
I know it is not uncommon for DIY model engine builders to make the valve seat and guide all in one piece out of bronze. I have used this method on a slow running, low power engine with good results. The guide and seat is turned and then pressed into the head. I'm not sure what the limitations are on this method with regards to higher performing engines.
Have a nice day...
We grind stellite hard facing all the time - it is blatant overhill and not something to even seriously consider for a DIY built R/C engine.
Besides, machining of the stuff is all but impossible, you will have to grind it, especially if you weld it into place as they do on steel valves that are hard faced. Stellite seats are all based on as-cast rings that are all machined soft and then heat treated hard and then finish ground to size.
If you can get a hold of an SAE handbook, you can find pretty much EVERYTHING you want/need to know about engine valves and/or valve materials in SAE spec J775.
In the latest SAE handbook, very near the J775 spec, they also list pretty much every guide and/or seat material known to man in two separate specs.
When it comes to valve materials, simply saying "bronze" (hundreds of alloys and most won't work) or "stellite" (same thing) nor for that matter "stainless" as in stainless valves (which one? there are many that suck for valves and many that are fine) is hardly adequate nor appropriate.
You need to indicate WHICH alloy or else you'll be in eminent danger of getting something that works for a faucet (bronze) but not worth a damn for a seat or guide.
Sadly, I lost access to the latest SAE manual or I'd give you the SAE specs for guides and/or seats too. The J775 spec is in the manual I have however it has been updated (mine is dated 1992).
NASCAR engines use primarily berylium bronze seats in concert with titanium valves. Steel valves (regular and stainles) are also used with berylium bronze seates. The OEM's use powdered metal seats (many, many alloys) in concert with conventional and stainless valve alloys in their aluminum heads. The prior mentioned SAE specs will identify suitable candidates.
Guides are powdered metal, ductile iron, cast iron and/or alumiun-silicon-bronze. Again, see the SAE spec for specifics.
It is important to note that valve metallurgy, seat material and guide materials are often iteratively developed in engines. That is, they try something economical (simple iron usually) and then start adding the trick, more expensive stuff if/when the simple stuff fails to live or provide the performance required. Amazingly, simple pearlitic cast iron still functions quite well for seat and guide material in many applications.
In light of an R/C engine having relatively SMALL valve head areas, the mechanical and thermal stresses from combustion should be fairly moderate as compared to say a comparable power to displacement ratio'd full size race/performance engine. You could ultimately get away with some pretty sedate materials.
Spend a few bucks and get the SAE specs.
For your application and what I would do is get a piece of cast pipe and machine it to the size you need. From there I would make a seat in the head that is very tight. Heat your alum. head and freeze your seat and press in place. You need a press fit when the seat is cold. I would then stake the seat in and machine the seat for your valve. After lap the valves individualy as per normal. I don't think you have to be to technical for your application but it is nice to know the alternatives.
Since its such a small engine, just cut the seats into the head.
The valves are small and your hours of running time is relatively short. IMHO, it is worth a try.
Just keep an eye on valve clearance to start with.
Worse comes to worse, you can always put in seat material later on if seat wear becomes excessive.
Seems like a neat project.
Good luck,
My experience with the valve seats cut directly into the aluminum head have been goodso far. Excessive valve spring pressure and too much guide clearance will have more of an effect on seat wear than heat will. Does the amount of combustion fire has less effect because of scaling size? Load allso has a direct effect. This is just my own thoughts and observations during testing, A.K.A. 'abusing' my single cylinder 4-cycle home design. Sustained 7000 rpm has shown little seat wear if any. I only use enough spring seat pressure to prevent float. The head is made of 7075 al. The valves are drill rod.
My small coles hit-n-miss allso uses direct seats in the aluminum head. This engine has well over 100 hours on it. I recognize that the valves are off their seats most of the time with this engine, but the intake valve is 'atmospheric' and you can hear it chatter on the seat during the intake cycle. I don't really see any appreciable wear on this engine either. compression is excellent on both engines.
My own experiences are rather limited. I am in the process of building the Kinner K-5 and plan to use aluminum seats, should I use iron seats?
I would like to hear others experience using aluminum heads/seats?


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Dallas Buyers Club | 117 min. | R | |||
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The story of Texas electrician Ron Woodroof and his battle with the medical establishment and pharmaceutical companies after being diagnosed as HIV-positive in 1986, and his search for alternative treatments that helped established a way in which fellow HIV-positive people could join for access to his supplies. |
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While subjected to the horrors of World War II Germany, young Liesel finds solace by stealing books and sharing them with others. Under the stairs in her home, a Jewish refugee is being sheltered by her adoptive parents. |


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This item may be Check for Availability Never Tell: A Novel of Suspenseby Alafair Burke
Synopses & ReviewsPublisher Comments:Sixteen-year-old Julia Whitmire appeared to have everything: a famous father, a luxurious Manhattan town house, a coveted spot at the elite Casden prep school. When she is found dead in her bathtub, a handwritten suicide note left on her bed, her parents insist that their daughter would never take her own life.
But Julia's enviable world was more complicated than it seemed. The pressure to excel at Casden was enormous. Abuse of prescription antidepressants and ADHD medication ran rampant among students; an unlabeled bottle of pills in Julia's purse suggests she had succumbed to the trend. And a search of Julia's computer reveals that in the days leading up to her death she was engaged in a dangerous game of cyberbullying against an unlikely victim. NYPD detective Ellie Hatcher is convinced the case is a suicide, but she knows from personal experience that a loving family can be the last to accept the truth. When the Whitmires use their power to force a criminal investigation, Ellie's resistance causes trouble for her both at work and in her personal life. As she is pressured to pursue a case she doesn't believe in, she is pulled into Julia's inner circle--an eclectic mix of overly precocious teenagers from Manhattan's most privileged families as well as street kids from Greenwich Village. But when the target of Julia's harassment continues to receive death threats, Ellie is forced to acknowledge that Julia may have learned the hard way that some secrets should never be told. Synopsis:Detective Ellie Hatcher will be forced to uncover the truth behind the apparent suicide of a teenaged girl with intriguing connections to both New York's wealthiest--and its most dispossessed. This addictive thriller from acclaimed suspense writer Alafair Burke draws its details from the author's own experiences as a criminal law professor and deputy district attorney, creating an exhilarating, true-to-life tale of crime and its consequences that is perfect for fans of Laura Lippman, Harlan Coben, and Burke's breakout standalone thriller Long Gone.
Alafair Burke is one of the finest young crime writers working today. --Dennis Lehane What Our Readers Are SayingBe the first to add a comment for a chance to win!Product Details
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text: Hi, im new to the scene, but i was wondering if someone could make a psp password boot lock to prevent someone from accessing the psp without the right password. Now i already know that if it is installed to the memory card then all someone has to do is pull it out. . . Well thats not what i mean, what if the password lock would be merged with the system bios like firmware, so when the system is started, the BIOS would be accessed and during the post test it would trigger the the password program planted in the boot process. Of course i know that if there is a bug/problem in the code we would all have a bricked psp due to the password not being reconized, but i am willing to take that chance, but im sure others are not. But if it's possible and if you can exceed a beta testing without a "lockout" then that would be GREAT! I would love to have this type of program so incase my psp ever gets stolen/lost, no one could even start the psp os, and they wouldnt be able to use/sell my psp on the streets. If it is possible and if ANYONE is up to the challenge i would GREATLY be thankfull to you, and if not, thx for atleast hearing my request.