text:
Wes Sneijder: analysis of world class player
Wesley Sneijder might be crowned the World Footballer of the Year soon. With VI, he analyzed the qualities of the player Sneijder. Yours truly gracefully took the liberty to share with you.
Sneijder's role models for the physical side of football are John Obi Mikel and Michael Essien. "Two beautiful specimen of players. I can really enjoy watching them for that, although they're both great players too. They do play more in a holding position though, not really on my spot. But still…"
Is physical strength important for a player on your position?
"It is. It always helps. The stronger you are, you know…it helps in challenges, in duels, even in the air. Players can't just push me over and I also think it protects against injuries. But players are always different. Take Jon Dahl Tomasson. He plays on my spot but does it totally different. His strength is his penetration, his timing and his capacity to use a split second to score. I'm more a position-loyal player. I can engage in a duel or take a player on, while a player like Beckham hardly ever did that…"
How do you train this particular aspect of the came: tenacity, condition, power, speed…
"I think the best practice is playing matches. There is no practice or fitness method that can copy the match as good as a…well…a match. I play two games per week now at top level, top speed, etc. And I would not have been able to do this at Ajax when I just started. I do use the fitness room and practice helps in particular to get to the right level but once you're there, it's all maintenance via playing matches."
When did you develop most?
"I think when I was around 23 years old. The thing is, you need to get intelligent and I might have been strong and fit when I was 21 years old but I lacked the smarts to listen to my body and to know what I couldn't do. Remember the training pre-Sweden? I decided to stay inside. Not train. I don't know how it works, but my body was aching a bit and I just knew I didn't need to train. It was better to rest. No doctor or coach could have convinced me that I was wrong and now, coaches like Mourinho, Benitez or Van Marwijk trust me 100% in this. When you're 20 years old, you simply don't know this."
Do you think Rafael van der Vaart is overdoing a bit now?
"Rafael is trying to find his new balance. He made the move to England and he needs to prove himself a bit, you always have that, and he needs to find the new balance with the pace and intensity against English opponents. You know that many hamstring issues are also mind or stress related? Rafael put pressure on himself by saying he would score against Van der Sar. Raf needs that, obviously, but sometimes it works against you. Remember my second season in Madrid? I wasn't doing well, both in my private life and in my football life and the result is little muscle injuries. That's never a coincidence. I know this now."
Is it hard to determine which knocks or aches you can ignore and which you need to give a rest?
"Yeah, see normally you train in order to convert those pains. If you take a knock, it's sometimes good to run it off. But the older you get and the more you play, the harder it gets. When I was 20 years old, a knock would be gone within a day, now it sometimes takes a week. But I hardly ever rest and Rafael is also not a player to bail easily so we are getting in that phase where you actually need to. I asked Gio in South Africa how often he trained at Feyenoord and he said "only in pre-season time, never during the season….".
Look at Oranje: Kuyt, Van der Vaart now, Elia, Robben, Van Bommel, Van Persie… Do you think it's getting too tough physically?
"The calendar is the problem. I see it at Inter too. We have many players injured and all players who played the World Cup. It's an issue."
You are the playmaker at the CL winner. Do you feel opponents try to take you out, physically. Do you feel attacked every now and then?
"Actually, no. It's getting less and less. Maybe they know I probably play better when they try to hunt me, but when I was younger, in Holland, it was tougher than now. I remember players in the Eredivisie doing really silly things. Trying to squeeze me, or grabbing me in my crotch… Maybe thinking, he's a youngster, we'll intimidate him, but it was meaner then than now in Italy. Weird eh?"
Really? Which players did that?
"Nah, I won't name names, but they were always players in low-level teams. Relegation teams. Maybe it was typical Dutch, haha. Dirty…"
When you were a talent in Amsterdam you were pretty skinny. Now you're one big muscle? How come?
"Just normal development. And nutrition. I don't spend a lot of time in the fitness room. There's not a lot of time for it. But I never was really skinny. When I was younger I had muscles too, but we played in wide shirts and shorts, so…"
Do clubs follow similar methods and concepts in practice and fitness?
"No, actually it's pretty different. Which is what I hear from the lads in England too. In Madrid, it's looser than here in Milan, but I think that's also the coach' influence. So, now with Mourinho in Madrid they probably have a bit more protocol. I spent time in the fitness school in my apartment building. But too much muscle is not good either. You become slower, actually. And less flexible."
Technical Skills
Sneijder's role model: "Barcelona's Xavi. Always perfection. Pure perfection. The right foot, the right first touch, always aware of what's around him, always the perfect paced pass…. The man is a genius. Scary."
Your kicking technique is phenomenal. Do you still perfect that?
"No. I think the technique is there. The basics are there and then you can perfect it but once you're at that level, you need to support it. The key thing now is, to be able to use to perfection at the right time. It's 0-0, finals Champions League, 2 minutes to go. You get a free kick. What do you do, haha…"
And you're two-footed… Which foot is the real natural kicking foot?
I'm right oriented. I had a pretty well developed left for passing, but Ajax' youth coach Jan Olde Riekerink kept on pushing me in the youth system. Constantly he said "Wes, develop the left, if you do you will be significantly better than your peers. You'll be quicker in execution, you can open left, right, you can score more, etc…" He deserves some credit, haha… I do think I had a talent already, because I developed my left foot really quickly. Others needed more time and effort for it."
Ajax always uses you and Rafael to boast that the youth system works well, but seriously…you would have been great anyway, right?
"Well… I don't know…. Sure, Raf and myself and others have that basic level of quality but Ajax really added a lot to our awareness and our skills. Don't underestimate that. At Ajax, they made us do aerobics, judo, all sorts of things and that's all based on a philosophy… No, I don't think it's fair to say that Ajax shouldn't claim this. Who knows where you end up otherwise. You know, at Madrid, when Cannavaro came to the club it took him some weeks to get to know me I guess, but he couldn't wait to ask me if I could ask Ajax for a youth development DVD. He was so keen to learn from what happened at Ajax. By chance, Ajax had just released a DVD and Cannavaro was over the moon with this and really studied it. And I thought, this guy captain Italy to the World Cup and wants to learn from my old little club. Cool."
Ok, the big question now: how come that the man with the best kicking technique doesn't take penalties?
"Whoa… haha…. I'll tell you. It's simple. I took two penalties for Ajax once and missed them both."
Come on! That's silly. You curl balls in the net from 20, 25, 35 and even further away from goal…. With goalies, walls and what not? And you're scared to hit a penalty?
"Well, I haven't overcome that yet, haha. True. I'm just not a penalty guy. It's a mental thing, I know. It's weird… Sorry…"
And in practice?
"I always take penalties and I always score. Shit, I always score when I take them in penalty series too. You're right, I should leave that behind. I remember them so well, you know. The first was stopped by Dennis Gentenaar, but Maduro still scored the re-bound so I didn't feel that bad. But the second… It was in a European game against Tel Aviv. I hit the ball so hard, it hit the post and it bounced back on the grass on our half! And that's when I said, "fukc it, no more for me". But you are right, I should grow up. I was 20 years old back then, I'm 26 now."
Ok, free kicks then. Ideal distance?
"Twenty meters. Perfect. Closer is getting tough due to the distance between wall and goal."
How many % chance to score from that distance?
What? That's four out of five??
"Correct. But that's only the actual 20 meter balls. That is the ideal distance. If it's 22 meters or 19 meters it's already harder. You know, the speed I can give a ball is too much for a goalie to respond at that distance and I can drop the ball or curve it around the wall. If it's 26 meters, the goalie has much more chance and if it's 18 meters a well positioned wall will stop you."
How often do you train this?
"Once a week."
"I'm not allowed to train it more. It takes too much power. Seriously, after training we are all obliged to go inside and drink drink drink. It's all different now. At Ajax, I did many extra practices with Koeman and others, but now? It's all regimented and checked."
Ok, which elements don't you do well?
"Nothing man! I can do it all! I can head a ball like Heitinga! Haha…seriously, I can't head a ball. Which makes it so cool that I scored a header against Brazil in a quarter finals. Can you imagine how crazy I got? If a medium or some wizard would have told me this I would have called them a quack! And Robben isn't your regular Peter Houtman either and he scored against Uruguay with his head! Too good…."
Sneijder's role model on this aspect. "Without a doubt Jari Litmanen. Man man….He was a master in moving and positioning. And he still is, you know. Before the Finland game, we saw a DVD of a game they played. And at the time you watch the game and think "Hey, there's a pocket of space there," some player penetrates it and is unmarked. And yep! It's Jari. He's always unmarked. He's the master."
What does it take to be good at this aspect? Finding space?
"That is hard. It's all about seconds, isn't it? And there's the dependance on team mates. Jari or whoever could make runs all day, if the ball never comes no one will notice. Do they see it, will the ball be played and will it be at the right speed, etc etc. Against Sweden, it worked so well. Against Sweden, Rafael would drop down and Wernbloom would drift along. I would start dropping back too and the minute they'd be confused and start to take over and communicate, we'd pounce. It worked well. In the first half I was unmarked fifteen times or so! It worked well against Moldavia too. You have to experiment a bit and talk amongst each other. Observe how the opponent moves. It makes football fun."
Do opponents ever sacrifice a marker to you? What do you do?
"I had that against San Marino. I could speak Italian with him. I said "Will you follow me to the toilet too?" and he said "Si, the trainer told me to follow you all over the place". It took until the 86th minute for him to touch the ball. I said to him: "you have more chance against me when you leave me some space. I make a pre-move and you're going into the wrong way" and he said "Wes, I know, but this is the coach' wish". When they took possession one time one of the Oranje players said to me "Wes, watch your man!" and I laughed. I said "Forget it, this man is going nowhere without me" hahaha…
Does Van Marwijk uses tricks and methods to get you in possession?
"Sure, we train on that and we talk about it. We use the flip charts to check out situations but we're always aware that on the pitch, the opponent makes up his own mind. But yeah, it offers up options for us and sort of helps us to program quicker decision making."
Do you ever drop down against the directions of Van Marwijk and pick up the ball?
"Yes, I do. When the ball simply doesn't come I can't stop myself from that. I'm not allowed really, because the action is close to the striker for me, but if I don't touch the ball I can't do a lot. I need that feeling so after a while I use some energy to pick up the ball."
You want the ball constantly, don't you?
"No not really. Well, in the past: yes. But I learned to be patient. Look, at the World Cup I knew I had to make do with moments. I wasn't that dominant in those games. And you need to work for those moments that you do have the ball and give all your skills, talent, energy and quality in those moments. It comes with the years, I guess. Against Sweden, I only had to stray passes!"
Actually, only one according to our stats. Amazing, for a player on your spot.
"Yep, and a year or two ago I would have had ten bad passes. Because I was trying to force the issue trying to turn every ball into a winner. Now, I'm more patient. Smarter. And against Sweden, I had two deciding passes. That is experience."
Was that all developed by Sneijder or did a coach or two help with that process?
"I think Mourinho was key in this. At Inter, he told me: you don't need to do the dirty work. I need you to be sharp and ready and waiting to give the killer pass or hit the mark. He'd direct me back if I was trying to support defense. We play differently at Oranje, but Van Marwijk also said to me that I could be important for the team without being dominating. And then there's the wisdom – football intelligence, I guess – that comes with the years."
Wesley's role-model: "Esteban Cambiasso is the man in this area. He's a true leader and mentally strong like an ox. He coaches constantly and is constantly yelling and keeping the team together. He is really important. Sometimes annoying, but he knows that too, of course."
You're a leader on the pitch too
"Yeah, I always had that. It's part of my personality. I always feel guilty if we lose. Supporters and tifosi sometimes say "Inter lost, but Wesley played well". I can't stand that. If we lose, I can't have played well, you know? Playing well means winning games."
And how about "you play like you train"?
"Nah man. All bull. For me, that is. I don't have that. Mourinho never forced that on us either. Whatever you did, but in the game you needed to be 100%. Mourinho is a tremendous psychologist. I don't think he actually thinks like a coach. He works the players. Some coaches will sit in front of the bus and be…well…the coach. Mourinho walks around, talks to the lads, joins in on card games or fooling around. He can look at you and say "Wes, you look tired man. Take a couple of days and have some time off with the Missus." You know when you come back, he will expect something from you, haha…"
And what if you don't deliver?
"You can get in trouble. He can be tough too. Eto'o didn't play sometimes last season. He said to the team manager he wanted a meeting with Mourinho. He came back and said "Mourinho doesn't have time for you, Samuel. And if it's about the line up, he won't have time for you at all. If you don't like it here, pack your bag and walk." Eto'o's face… Hahaha…. And after a while, Eto'o played winger and started to defend and track back. Mourinho is a wizard."
Last questions: who were your idols?
"Didn't really have any… I did have one poster on my wall, with the Milan big three. Van Basten, Rijkaard and Gullit."
Most remarkable goal?
"Well, the Brazil header…haha… No, the goal against PSV. The distance strike from the left."
Most important goal?
"Oooh…. In the 2004 season, against PSV I think I scored one of those key turning point goals. We were 1-0 down and Vennegoor of Hesselink hit the post and out of that counter attack I scored the 1-1 against Waterreus. Mitea scored the winner later, and that was one of those key games."
Biggest misser?
"Those two penalties, I guess…"
Toughest direct opponent?
"Shinji Ono of Feyenoord. He was strong and fit but he was also a tremendous player. Whenever he would get away from me I had to work hard to mark him. He'd go all the way to the striker and you simply couldn't let him walk away from you. Very skilled player."
Best team mate?
"Guti. That bloke is so good. He's got a phenomenal through ball. Great vision. I tried to get him to come to Inter, but it didn't happen. We had a good connection."
Best game ever?
"I'd say the Chelsea game last season in the CL. I think I came close to a perfect game. Or the Scotland decider for the 2004 EC. Although I wasn't as good then as I have become now…."
Displaying the most recent 25 comments from a total of 111 comments.
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He should not have called Van Bommel and Van Persie,they are not fully match fit and probably wont be when that friendly comes. De Guzman should have got a call instead of Van Bommel,and maybe Wolfswinkel or Luuk de Jong or even Drenthe instead of Van Persie.
Netherlands doesnt give younger players enough chance,even in friendlies! Is it that hard to just call De Guzman this time to "secure" him for Netherlands??
Ibrahim Afellay (PSV), Mark van Bommel (Bayern München), Khalid Boulahrouz (VfB Stuttgart), Wilfred Bouma (PSV), Wout Brama (FC Twente), Eljero Elia (HSV), John Heitinga (Everton), Klaas Jan Huntelaar (Schalke 04), Theo Janssen (FC Twente), Dirk Kuyt (Liverpool), Jeremain Lens (PSV), Hedwiges Maduro (Valencia), Joris Mathijsen (HSV), Ruud van Nistelrooy (HSV), Robin van Persie (Arsenal), Erik Pieters (PSV), Stijn Schaars (AZ), Wesley Sneijder (Internazionale), Maarten Stekelenburg (Ajax), Rafael van der Vaart (Tottenham Hotspur), Michel Vorm (FC Utrecht), Gregory van der Wiel (Ajax), Peter Wisgerhof (FC Twente) en Demy de Zeeuw (Ajax).
*Nigel still left out
Xavi might be quitting from Spain soon, that'll open room for Fabregas, but hes a totally different player, will be interesting to see what happens.
Posted from Netherlands
After Ozyakup, Hiddink also tried to talk Ciftci of Portsmouth to switch to Turkey…
Posted from Canada
Ozyakup has already said, relax people, ill see that later, ive always played for oranje youth teams and im fine with that. So basically saying hes not thinking about switching anytime soon at least. Don't knwo about Ciftci though.
Posted from Netherlands
BTW, I'm still saying with Belgium we would undoubtedly be in the worlds absolute top easily for at least 15 years… I'm saying this on every oranje blog, trying to raise support, lol
Posted from Netherlands
Some questiones:
*Wisgerhof can be in the starting XI??? I haven't been able to see him play.
*Boulah is a regular at Stuttgart or is he still a benchwarmer?
*Someone said De Guzman deserves to be called but what about Drenthe???
take care guys
BTW, I'm playing FIFA 11, with De Guzman, Drenthe in the selection, Douglas Dutch and in the line-up, made Vermaelen, Kompany, Fellaini, Lombaerts and Hazard Dutch as well
——-De Guzman-V.d.Vaart
———V.Persie/Huntelaar (switch it up according to opponents)
Works better than ever, im winning with crazy scores seriously, lol one touch football.
Posted from Netherlands
mostly Fellaini instead of De Guzman though
Posted from Netherlands
Drenthe and De Guzman will come in the selection eventually if they keep it up, i dont worry about that… they will eventually, but V.Marwijk just lets it take a very long time….
Posted from Netherlands
Hi Guys,
I tremendously enjoy coming here since this summer, so I thought I too would join the group officially. I am 1/4 dutch from Switzerland (no, vB is not for van Bommel .
Anyway, if anybody has a good english link for the Real-AC tonight, don't hesitate to share it… Cheers!
Welcome Guillaume ( that Willem in French) it's good to have you hear vocally as well .
Emanuelson will walk away from Ajax transfer free.
If people wonder what is going wrong in Holland with Ajax, Feyenoord and PSV, it's that.
They can check all the boxes ( youth development system? Check! Scouting? Check! Attractive to youngsters in the region? Check!) but forget to make money at the end of the cycle.
It's like Apple developing iPhones, iPods, iPads and iMacs and allowing people to walk away from the shops without paying for them.
De Guzman, Afellay, Van Persie, Emanuelson…drives me nuts. This is what JC means with his criticism. Ajax tells the world they developed those wonderful talents and are so cool and all, but they simply can't turn it into gold. The system might be wrong but what do the clubs do about it? I can't see it. Drives me nuts. Expect an article on this.
does anyone have a link for Ajax?
Posted from United States
I'm sorry for ajax.
It sucks. The CL has become the stage for the big clubs (should add filled with debts!) and the small clubs have no chance. The whole thing is a total joke.
Regarding Ajax, they are so inconsistent it is amazing. One day they play really well, the next they are terrible. Let's hope they will finish with a bang. And now they have to regroup and play ADO which is not going to be easy.
Posted from United States
i thought they played pretty well in the second half.. they were just unlucky, and understandably a bit immature..
I though that ajax's gonna make a headline, 1 nil behind, replaced enoh and anita for forward & more attacking minded midfield, sulajmani & dejong, so they play like 3-4-3, more than 60% possesion, and win. but the end was not so good.
Posted from Australia
Well, by including MVBommel and V.Perise does not mean that both of them will play. They could just come along, socialize, take a chill pill u know what i'm saying? hehe. Just catching up with the mates, nothing wrong with that. BVM is a genius.
By the Way folks, did u guys see Spurs vs. Inter? Seems to me like Sneijder was having trouble with the pace of English football, since we all know how sh tty the Serie A is.
O_C – I dont think Sneijder has problems with the pace, what annoyed him most was that when he did get the ball, no one was making a run. He shouldnt just have to look for Eto every time. That is what was frustrating him.
Carlos that does fit why this season he has still looked very good for us.
You have to remember that he had good chemistry with Milito last year. With Milito on the bench and with wingers like Pandev and Biabany only Eto'o is a good option for him.
Once Milito came on Inter was functioning much better up front again. Immediately when he came on you could see the connection Sneijder, Eto'o and Milito had last year.
You just see the same thing over and over again, coaches using their best players too late using the "impact player" philosophy.
Oh how well it's working for them.
Milito not being up for a full match is no excuse to not start him in the first half, even if it's for only 20 minutes or so. You can accomplish so much more in the first 20 minutes of the game than in the last 20 minutes for a variety of reasons (fitness/stamina of the team not even the most important one).
Posted from Netherlands
But Inter was doomed anyway, cause VDV > Sneijder
Posted from Netherlands
and in Dutch ">" literally translates to "bigger than" instead of the English "greater than". For those who didn't get the pun (which you probably wouldn't if you weren't Dutch I realize now, duh).
Posted from Netherlands
It's also > "more than" in English …but I happily disagree on that in general but on that day yes VdV > Sneijder…isn't it great to have both of them in your side.
Now a funny thot and for those here longer than a year I also said a "funny" thing when the qualifiers were starting about Bayern(Robben) meeting Inter(Sneijder) at Bernabeu (RM). Now wouldnt it be funny if Spurs meet RM somewhere along the road and Raf Kicks Ass !!
Great interview!!! He's my favourite for the Ballon d'Or.
He's a great example of not having to be a 6ft+ physical machine. Great technique on both feet, great vision and intelligence. Hopefully Siem de Jong will make it to a similar level. Ajax could do with it…
Posted from United Kingdom
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Asian language search bug
andy duggan
Joined: 2006-05-21
Posts: 84 |
Posted: Sun, 2012-06-03 13:22 |
Using gallery 3.0.3 Odd behaviour with the search and chinese/Japanese kanji characters. It does not return any results when a full name is used, and also part name using one or more characters. At first it seemed to return results if the first character of a name was used but for some search phrases it wasnt working either. Examples All part word searches return results The traditional kanji characters don't work as well. Search: 山急山 Search: 山急 Search: 山 Search: 妙義山 Search: 妙義 Search: 妙 These are also popular tags but the search doesn't pick them up. You can try it yourself copying and pasting tags or parts of album names. |
Joined: 2005-12-17
Posts: 1753 |
Posted: Mon, 2012-06-04 14:50 |
Have you tried this?: http://gallery.menalto.com/node/104571 EDIT: I now see that you've already commented in that forum about not getting the patch installed. If that's a working solution, you should keep the conversation there. Not sure you'll get anything different here and there are users there already trying to help you. |
Joined: 2004-08-02
Posts: 769 |
Posted: Mon, 2012-06-04 15:11 |
Comments are now locked for this topic. |


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nakapunta na ako sa vietnam, HCMC, masasabi ko ***, mas mainit doon kesa ** sa pinas
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read morenakapunta na ako sa vietnam, HCMC, masasabi ko ***, mas mainit doon kesa ** sa pinas
Has anybody been to Hue? Gaano katagal yun from Saigon by public transport?
I'll be going on business trip to Hanoi late in January and was wondering if you guys could recommend the places and sights to see in Hanoi. I've read about the Old French Quarters and the Water Puppet Show, Are there any other places to visit?
Also, which of the 3 hotels would you recommend in terms of how accessible it is to the city center, malls, dining areas, etc.
- Horison Hanoi
- Sheraton Hanoi
in Ho Chi Minc City, Vietnam now!
grabehh ang init nga dito
halos lahat ng vietnamese my sobrero
ang dami ngang motorbikes at scooter..nakakaloka!!!
hi, any idea what's the visa requirement for philippine passport holders? will be going to vietnam this june/july.
No visa needed Hooray!
dumaan lang kami here e.. nag cruise kami sa starcruise then one day stop sa HCMC. parang pinas sha in a way... dun lang kami sa market pumunta e.. prang tiangge. then kumain sa vietnamese resto.. pho bac ata name nung resto... free wifi pa hehehe
yes no need to get a Visa to go to Vietnam
social visit of 21 days are given to Philippine passport holders
ive stayed for 1 week in Ho Chi Minh City(Saigon).
parang Philippines din sya pero wala pa masyadong malls and buildings. mas malinis ang Vietnam kaysa sa atin.
tsaka bihira ang pulubi sa kanila.
di nila masyado ginugulo ang mga tourist, di tulad sa atin na kapag may nakitang tourist hinahabol ng mga pulubi at todo hingi ng limos, kapag di nagbigay minumura nila yung tourist.
mababait ang mga Vietnamese at hardworking people.
sobrang daming motorbikes at scooter.
in a few years mas maunlad na sila sa atin
by the way nice places to visit there are Na Thrang Beach, Phouc Island, Mekong River cruise, Halong Bay
have fun!!!
worth it ba mag mekong river cruise?
Been to Danang I like the marbles.
I've been in HCMC, (Saigon) Vietnam since January 2007.
- Great food- healthy...lots of greens. I think it's because of the war they went through...lahat ng color green, kinakain. Yung gulay na pinakakain lang natin sa baboy sa Pinas, dito kinakain namin. I don't mean it in a bad way, but bow ako sa kanila the way they prepare their food....lots of veggies every meal, together with fish...and then their noodles (pho) are good. If you're adventurous enough, it's better to eat pho in the side streets, like carinderias in Manila. Pho 24 is not as good. It's overrated, at least for me.
- Motorcycles are crazy!!! It's madness....it's totally insane. The rush hour traffic is composed of an island of motorcycles. It's terrible!! Ingat lang sa pagtawid dahil mahilig mag cut ang mga motorcycles and they don't give you any warning at all, so kung nabundol ka ng motor, sorry ka na lang.
- I do not really enjoy shopping much here in Saigon....in a way, some stores are mala-Pinas...but places to go to: Cholon (Chinatown), Bin Tay Market, Ben Thanh Market (this is haven for the tourists, lots of cheap goods, knock-offs, branded overruns, you name it, you have it), Lucky Star (Russian market). For upper class shopping, go to District 1, in Dong Khoi Street (where Parkson and other high end local boutiques are located- you can have your ao dai- their national costume custom made from there). Or go to Hai Ba Trung St (shopping haven din dun). Diamond Plaza is a good place to go as well.
- For cheap overruns and knock offs, you can go to Saigon Square. Lots of good stuff there....hard to find dvds meron dun....knock offs yun, of course.
- There's a new series of shops in Dong Khoi St. Opera View Boutiques....meron nang LV dun....newly opened lang and right in front of LV, there's Gucci already, D&G, etc. Not sure if they're cheaper than Manila branches, though.
- Famous bakery in Saigon is the Brodard Bakery in Dong Khoi, it's located inside the side street where Gloria Jean's coffee is. Good pastries. Another mass market bakery for you to try is Duc Phat....they have really, really good Banh Mi---it's like a foot-long Subway sandwich, and only for 18php. Cool. Desserts here in Vietnam, even the cakes are generally not as sweet as what we have and they're almost always fruit based. The cheesecakes in Vietnam are to die for.
- For coffee, it's good to try Highlands Coffee..It's their local version of Starbucks and Coffee Bean and Tea Leaf in one. They have a good ambience (outdoor and indoor cafe) and nice selection of teas and coffees.
- Vietnam (Saigon) has a great selection of premium coffees. Coffees here are drank like water. So yung mga mahilig sa coffee, masaya kayo dito. Pero beware, their coffees here are generally strong (as in!)
- Language barrier is prevalent. It's difficult to communicate, esp. with the taxi drivers and the people on the street. 80% of the time, hindi talaga marunong mag English. Yung landlady ko nga eh...hirap na hirap ako....
Anyway, sorry kung medyo magulo ang Saigon 'insights' ko. Pag may tanong kayo, I'll gladly answer...hehehe.
doolfreak_bige, thanks so much!
I'll be going to HCMC this August, nae-excite ako!
I heard nga that North Face backpacks are cheaper there--how much are they? Saan makakabili nung bags?
Hmmm...some people say na marami raw sa Saigon Square na Kipling and North Face bags...pero careful bec. maraming knock offs din. Merong iba mukhang legit naman....maybe around 600 bucks yung mga large backpacks na Kipling, but as i said, i have totally no idea kung legit ba or knock offs bec. i hear that it's really hard to tell
Meron din ba sa Hanoi na mapagbibilhan ng Orig na Northface bags?
I really liked Vietnam. I expected to hate it since I was pissed off by being charged HKD1000 for a 14-day Vietnamese visa (some people got a 30-day visa for under USD50). I really like Hanoi with its old French colonial architecture. If you are in Hanoi, make sure you watch the water puppet show. It's really cheap (only VND20,000) and it's totally worth the money. Halong Bay was breathtaking (see other thread) and the Citadel and royal tombs at Hue were spectacular. Saigon was awesome as well and the day trip to the Cao Dai temple and Cu Chi tunnels were nice. Unfortunately, I didn't have time to visit Sapa, Nha Thrang, Dalat, or even the Mekong Delta.
You may want to consider flying with Vietnam Airlines. I flew from Hue to Saigon for about USD70 (business class). They didn't have any economy seats available since I booked only 1 day before the flight. You should visit Seat 61 since they have a timetable for the selected route. It is more than 20 hours though by train.
i have 2 northface bags bought from russian market, and based sa nakita kong "northface" bags in bangkok and phuket, overruns yung nasa russian square. if you check carerfully, may mga small defects sila, but still, original items. kung may pupunta ng saigon, mag-hoard na kayo ng northface bags, especially yung mga waterproof!


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Greetings All,
Typically on web presses when the job content does not extend to the edges of the roll bars are added to the outer edges to help maintain ink and water balance. I've heard them called mooring bars, mourning bars and take off bars.
Do you use them?
How do you use them?
What do you call them?
How do they work?
What is the impact on CIP3 ink key control systems?
Phil Crosby - Senior Trainer - Agfa Graphics North America


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text: In the final analysis In the final analysisBy Annalee Newitz PO Edit1182L Battlestar Galactica Didn't Need Outer SpaceCritically-acclaimed TV series Battlestar Galactica broke one of the cardinal rules of hard science fiction: It wasn't really about science. Instead it was hard social fiction, a realistic look at the future of human culture. Read… 3/31/09 3:57pm 3/31/09 3:57pm


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What is the best audio format for websites?
SilverHawk 29 weeks ago
I was thinking of adding some fairly short informational audio tracks to our website - maybe moving into weekly podcasting if it gets any traction. What is the best audio format choice for file size, decent audio, and compatibility with different OSes?
Topic: Development
Answer this Question
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Cees Timmerman 19 weeks ago
MP3 is most widely supported by digital players, but i think Opus will be the next big thing as it's free, standard (RFC 6716), and better than AAC (used in MP4). Popular software like Firefox, VLC, and Foobar2000 already support it, and once 1.1 is final, the rest should follow.
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If you're building applications for Android and iOS, cross-platform mobile development tools can make you more productive. Just don't expect the results to look pretty.
Penny Arcade gets points for honesty in their recent job posting, but not much else
Hackathons that offer big prizes are susceptible to accusations of being fixed, like Salesforce's recent $1 million competition
Crowdsourced data sheds new light on the gender gap in software development
A new survey of federal IT executives indicates strong interest in hosted application development to cut cost and improve efficiencies, though PaaS adoption currently remains weak.
Google's Civic Information API now includes data on U.S. government officials
An examination of the tech skills mentioned most often by telecommuting job listings finds that the ubiquitous scripting language is number one
Job listing sites are catering more to people who want to work from home
More hackathon organizers are giving out big prizes, which some developers think is a bad idea
The Age of the API is upon us, presenting developers with new opportunities to generate income by linking to the data and services of others. But developers need to be careful when navigating the new API landscape.
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Tripping over cords onstage is a profes- sional hazard. It's stupid, we've all done it, and sometimes with disastrous results. I recall doing it one time in front of a club full of onlookers, and unfortunately, the cable was connected to my guitar that was standing on a riser. I watched helplessly as my favorite guitar—a Rickenbacker— bounced once on its headstock and then sprung into the air like a pogo stick before coming back down again on its face. The entire event lasted just a few seconds, but the damage was done. A clean crack of about 4" now ran through the 4th- and 5th- string tuner holes. Unbelievably, the guitar was still in tune and I was able to carry on with the gig. Was I just lucky or did the design give my axe more of a chance?
Over the years, different guitars have acquired reputations for their ability (or not) to stand up to abuse. So why don't all guitars sport sturdy, break-resistant pegheads? As a builder, headstock strength is only one small item on my checklist of concerns when designing a guitar, and as always, it's a balancing act. Of course, you can eliminate the headstock completely and move the tuners to the opposite end of the string length. It's hard to break something that isn't there.
To design a headstock, you have tothink in terms of three dimensions, oraxes. We usually think about the first twowhen considering the shape of the designas viewed from the front. This affects stringlength and angle relative to the guitar'scenterline. The two-dimensional design iswhat gets the most attention because thepeghead shape is often the signature of aguitar. Designing a head shape that's uniqueisn't as easy as it might seem because thereare quite a few absolutes that have to beobeyed. It really comes down to geometry,which is determined by the path of thestrings. The lines of the strings are gener-ally tapering down to a single point that istheoretically off the end of the headstock.If you want to keep the line straight, thereis a finite place where this line intersectsthe outside diameter of the tuner capstanpost. Straight string pull has an effect onboth tuning and vibration transfer, andthey are somewhat at opposite ends ofthe tug-of-war. If the design calls for thisstraight string pull, the limiting factor forshape is now the clearance distance betweenthe tuning machine's gear housing and theinside edge of the tuning key. There are var-ious ways to address this—curves, stairsteps,and angles—but there's not a lot of wiggleroom on the sides. This generally leaves thetip of the headstock to make your state-ment. In order to go beyond this constraint,a builder will have to angle or "break" thestring as it comes off the nut, which is gen-erally the case.
The headstock: We may take it for granted, but a good design balances many considerations.
I think it's more complex than just size.
I do, however, believe that the headstock does vibrate in the manner of a tuning fork at the end of the neck, and it can be tuned to enhance, or at least vary, a guitar's nature. Anyone who has clamped a capo to the end of the headstock will tell you it makes a difference.
Another often-overlooked aspect of the headstock is that a string's overall length determines its tension at pitch—longer being tighter. This may be one of the most important things to consider when determining the tuner locations, with the difference between in-line and split-side configurations being the most obvious. In-line designs can make the overall length longer, and the strings at each end are subject to different amounts of tension. A builder can manipulate the lengths to change playability and tone this way. Another way to balance tension is to split the sides unevenly by, say, four and two, or even five and two for 7-string instruments. Any approach will have consequence in size, strength, and sound.
So far, we've just looked at two-dimen-sional shape, which is pretty easy. Drawingin two dimensions on a flat surface isn'treally designing, because it doesn't take intoaccount a number of structural demandsthat exist in three dimensions. The thirdaxis gives us the backwards headstock angleneeded to seat the strings firmly in the nut.A most notable exception to this is LeoFender's design, which accomplishes almostthe same effect by scalloping away the head-stock's face to create string angle. The short-coming here is the need for string trees toincrease the break angle, which can hampertuning stability. The payoff is ease of manu-facture and cheaper material costs, alongwith a very robust headstock. It's prettyhard to snap a straight piece of maple.
JOL DANTZIG is a noted designer,builder, and player who co-founded HamerGuitars, one of the first boutique guitarbrands, in 1973. Today, as the director ofDantzig Guitar Design, he continues tohelp define the art of custom guitar. To learnmore, visit guitardesigner.com.


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We stayed at this location for a couple of nights. STAFF is AMAZING - EVERYONE - rooms were clean - beds were sharp - lots of channels on television - it's PERFECT for a GROUP coming to stay at the hotel. The only issue I had with the entire stay was the trashcan in the front of the hotel tends... More
- Also Known As:
- Country Inn Evansville
- Evansville Country Inn
- Official Description (provided by the hotel):
- The Holiday Inn Express Hotel & Suites Evansville offers 69 guest rooms with 24 one bedroom suites and 6 whirlpool suites. The Holiday Inn Express Hotel and Suites is located at the northwest corner of I-164 and Lloyd Expressway on Evansville's East side. The hotel features complimentary hot breakfast and free local phone calls. Visit Evansville, and Stay Smart at the Holiday Inn Express Hotel & Suites. Conveniently located just five miles from the Evansville Museum of Art and the Reitz Home Museum. This Evansville hotel is close to popular attractions like the Casino Aztar, Eastland Mall, historical New Harmony, historical Newburgh and Mesker Park Zoo with the new Amazonia. There are a wide variety of restaurants and cocktail lounges located in the area. The Evansville Dress Regional Airport is 10 miles from the hotel. Ivy Tech University, the University of Evansville and the University of Southern Indiana are also nearby. Free deluxe Continental breakfast, free hard wired and wireless high-speed Internet and exercise room. Also we offer discount passes to Tri-State Athletic Club, Evansville's premier private health club for our guests. 100% smoke free hotel. ... more less
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Posted: Dec 27, 2012 10:01 PM by Christina Jensen, KSBY News
Updated: Dec 28, 2012 5:13 AM
California Govenor Jerry Brown has appointed a new San Luis Obispo County Superior Court Judge.
Rita C. Federman of San Luis Obispo has served as a United States Magistrate Judge for the Central District of California since 2004.
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Federman will earn over $175,000 in the new position.
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By Steve Nelson
Arizona Senator John McCain has wrapped up the Republican nomination for President
Last week was a typically schizophrenic one for U.S.-Russia relations. On one hand, we saw outgoing Presidents Bush and Putin agree to meet in the Russian resort city of Sochi in order to address their differences over a proposed American missile defense system in Europe. On the other hand, we saw Arizona Senator John McCain, the Republican candidate to succeed President Bush, argue that Russia should be kicked out of the G-8 club of industrialized nations.
In a speech delivered to the World Affairs Council of Los Angeles on March 26, McCain acknowledged both Russia and China as nations "that wield great influence in the international system". But while McCain made a point to emphasize that the U.S. and the China were "not destined to be adversaries", the Senator's stance versus Russia was decidedly more confrontational.
Continue reading "McCain and Washington's Doublethink on Russia" »


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Requirements for Backflow Prevention:
For additional information regarding the City's Backflow Prevention Program, please contact Customer Service at 913-971-9055 or Cross Connection.
Submit all test reports to: City of Olathe Cross Connection Control Program, 1385 S Robinson, Olathe, KS 66061 /OR/ Email Cross Connection /OR/ Fax: (913) 971-9199
As a friendly reminder, irrigation systems should be winterized and backflow preventers should be shut off, drained and/or removed for the winter season. If your backflow device does freeze and break, a new one is required, as well as a Cross Connection permit.


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The past couple of weeks have been extra special busy. First a few bullets to get some quick things out of the way:
- More on the New Year Challenge below, but I wanted to say that I haven't weighed-in since before the super bowl, and won't for a few more weeks due to a little glitch (the scale was in LA). I had a rough week eating-wise, but am keeping up with my workouts.
- If you read my tweets, you may have noticed I spent a Sunday morning not too long ago waiting in line to buy a Cricut for cheap at BigLots. Well, I got one of the 5 that were in stock and I LOVE IT! I can see more scrapbooking in my near future
- Cross your fingers that I get an interview this week at a place I applied to a few weeks ago. I have already made it through the phone interview and hope to hear back soon.
- I am doing a market research thingy on cat food tomorrow — so excited to have a little extra "go" money. What shall I spend it on? New workout clothes? Sketchers shoes? Cricut supplies??
- I have been having a bit of trouble sleeping the past few nights– I think the cats are keeping me awake. I need to shoo them out of my room tonight and see if that helps. I need to get a good night's rest!
OK– here go the long-ish updates–
Naked Fitness New Year Challenge: While my eating has not been the best this week (Valentine's Weekend was a disaster!! Fries! Fried Pork Tenderloin!! Candy bars!!! (yes BARS; PLURAL), I stopped myself on Monday and restarted. Wait– Actually, I started over search day eating a healthy breakfast but ended each day of my 2 day crap-binge with, well, CRAP. On Monday I seemed to get my healthy-head back on, and really stayed within my calorie goals for each day.
I was proud that I got 2 hours of walking in each day (except 1 or 2– those days I walked 1 hour). I made the realization that every day was not going to be "perfect" because
Some days I am going to slip up a bit, and that is OK. I can start again at the next snack or meal. I had to realize I was tired and not planning properly so I was not getting my meals at the right time, so I was starving and grabbing whatever I could find (ie: fast food) and shoving it in my mouth. I need to slow down, plan my meals and eat what makes my body "run" the best is can.
I made up 4 shredded chicken breasts in the crockpot tonight so I can add it to my meals over the next few days. I just added the chicken to a can of low sodium chicken broth in my crockpot this morning and by about 6 pm, the chicken was so done it just shredded in my hands. Look at me preparing my meals ahead of time!! lol
I forgot to drink the supplement drink, Elations, that the trainer had asked us to use during the initial 21 days (mostly because I ran out of the bottles). My knee really started giving me problems as I was walking– the joint was really sore and uncomfortable. After being back on the Elations for 3 days, the discomfort was GONE! I really believe in this great little product! Glad Andrea asked us to try it! (NOTE: I received free product from the trainer as part of the 21 day fitness program, but have run out of the free product and am now purchasing it for myself.)
I spend an hour or so at NBC 5 here in Chicago taping a segment that will be shown March 2nd on the 10pm news to highlight the work we did over the 21 days of the initial program. If you are in Chicago, please check it out.If not, I will try to post it from their website the night it airs. Andrea (the trainer) told us today that NBC 5 will be following us throughout the year to see how we do on the plan. I am HAPPY I will have the follow as I need something to keep me honest!
Within the next few days (hopefully Wednesday) I will post the whole menu, and guidelines to follow if you would like to try this new way of eating/working out. Well, I guess it is not a new way of eating, per se, but a healthy way of eating. I have a very full day tomorrow, so give me a day or so.
Fitbloggin 10– I can't believe Fitbloggin is just around the corner. Amerrylife is my roommate and I can't wait to hear all about her trip to New Zealand to see her love in person. I think I may have secured a sponsor (or 2) just this afternoon. More information as soon as I can share. I am SO EXCITED and want to share but want to make sure everything is firm before I do!! I know you understand.
Speaking of this (awesome) guy, if you have any spare change, and you believe in true love, PLEASE go to this post, read, and donate what you can. Their story is SO SWEET. Thanks in advance!
I leave you with a yummy recipe- Enjoy!
Chili-Lime Pork Chops
4 servings
1 teaspoon chili powder
1/2 teaspoon garlic salt (I used garlic powder)
1/8 teaspoon ground red pepper (cayenne)
1 tablespoon line juice
1 teaspoon canola oil
4 boneless pork loin chops 1/2 to 3/4 inch thick (1lb)
If desired: Chopped fresh cilantro; lime wedges
1. Pre-heat grill
2. meanwhile, in small bowl, mix all seasoning ingredients. Brush mixture evenly on both sides of each chop.
3. When grill is heated, place pork on grill surface. Close grill, cook 5-7 min or until pork is no longer pink in center (AP note: I turned mine once 1/2 through cooking to get good grill lines). Sprinkle pork with cilantro and serve with lime wedges.
1 serving: 190 Cal, Fat 10g, Sodium 170g (maybe less with sub garlic powder).
Taken from Pilsbury Fast and Healthy Cookbook.


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More copies of this ISBNThis title in other editionsDear Bully: 70 Authors Tell Their Storiesby Megan Kelley Hall
Synopses & ReviewsPublisher Comments:You are not alone.
Discover how Lauren Kate transformed the feeling of that one mean girl getting under her skin into her first novel, how Lauren Oliver learned to celebrate ambiguity in her classmates and in herself, and how R.L. Stine turned being the "funny guy" into the best defense against the bullies in his class. Todays top authors for teens come together to share their stories about bullying—as silent observers on the sidelines of high school, as victims, and as perpetrators—in a collection at turns moving and self-effacing, but always deeply personal. About the AuthorMegan Kelley Hall is the author of Sisters of Misery and The Lost Sister and has written for a variety of publications, including Elle, Glamour, Parenting, the Boston Globe, and the Boston Herald. She lives north of Boston.
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Services for Barbara W. Coleman, 73, wife of William S. Coleman, will be held in Rogers Funeral Home at 2 p.m. Monday.
Mrs. Coleman, who died peacefully at her home on Friday, will be buried in the Frankfort Cemetery.
Born in Versailles on December 13, 1938, Mrs. Coleman was the daughter of the late Max T. and Katie Elizabeth Adams Woods. She spent many years in state government, working with the administrations of governors Julian Carroll and John Y. Brown and as an administrative assistant to Jim Fleming and Jackson White at the Legislative Research Commission. She was a long-time supporter of the Franklin County Humane Society and a member of the Frankfort Garden Club, the Younger Women's Club, and the First Baptist Church.
Mrs. Coleman is survived by her husband of more than 55 years, William S. "Bill" Coleman; a son, Robert J. Coleman; three sisters, Jane M. Evans, Darlene C. Ransdell, and Patricia C. White; one brother, Gayle A. Woods, and a dear friend, Mary Cull, whom the family would like to thank for her kindness and compassion.
Bearers will be Hank Hancock, Winston Rogers, Dutch Hatterick, Cecil Iglehart, Tom McBride, Roger Roberson, Dickie Dawkins, Joel Ransdell, and Paris Hopkins.
Honorary bearers will be Larry Oberlin, Ken Martin, Earl Gregory, Sonny Hunt, and Jim Stivers.
Friends may call at Rogers from 1 to 5 p.m. Sunday.
Flowers are welcome, while the family also appreciates donations to Hospice of the Bluegrass in thanks for their loving care and assistance.
Bill, so sorry to hear of Barbara's passing. Please know that I will be praying for you and your family over the next few days as well as in the days to come. The loss of any family member is difficult, and especially your spouse. The Holy Spirit is the only comforter I know. After David's passing, and in those times of mourning, I ask God the Holy Spirit to comforter me "Right Now"! He never failed to do that, Jesus said, He would send the comforter when He went back to the Father. I can attest, as I am sure many others can do as well. He is the Great Comforter, but we must ask Him. John 14:14-18. Betty Lampkin-McMillen
Bill, Our thoughts and prayers are with you and your family in the loss of your precious wife. Wish I could be with you at this time.
My aunt Barbara was a wonderful lady in every way. She will be missed. Mike Coleman
Apologies for the mistake - the funeral service will be held at 2:00 pm on MONDAY.


text: Wanting a base to tour some of the Zulu battlefields, we chose to stay in this rather 'off the beaten track' Lodge. We were certainly not disappointed. The valley itself is a hidden gem, unspoilt & verdantly green, with an abundance of flaura & fauna. The lodge is lovely. We ate dinner by candlelight & silver, surrounded by prints of... More


text:
Prayer Circles
Read Prayers. |
bridgesofstone 12/22/2000 02:29 |
pam i hope your doing good to day |
dese5 12/28/2000 09:48 |
Dear Lord please heal Pam, remove any cancer, bless & cure her, please also hear the prayers of bridgesofstone & fill her needs & guide her. Amen |
klusk1 12/29/2000 15:54 |
God, in Jesus name, Please heal PAM. |
SugarPlum54 1/26/2001 20:56 |
Dear God, Please heal, guide, and comfort Pam and her family during these trying times. My Pam and her family's future be full of love, health,and hope. |
moonliner 5/18/2001 07:49 |
God is with Pam through this journey, and will stay beside her and her family, bestowing His gifts of Love, Faith and Hope. I pray that they feel His Presence. I am so sorry that this came upon you and will pray for healing and strengh. Amen |
ashenaskye 5/22/2004 20:52 |
Beloved Father, in the name of Jesus please heal Pam and give her strength. |
Has problems James J 02/12/2008
My Uncle Dennis Worthington 02/12/2008
My marriage Kat Mounce 02/12/2008
A good friends mother, who has cancer everyone who needs prayer universal 02/12/2008
Pray for Michelle and Carlos N. 07/08/2008
"This prayer is to help us sell our home."
Pray for Donald H. 07/07/2008
"The love of my life has cancer."
Pray for Amanda B. 07/06/2008
"Please pray for my daughter and her unborn child."
Pray for Janice A. 07/05/2008
"One of my most favorite people in the whole world needs your prayers today. Please spread this and include Janice in your daily prayer."
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text:
Trainers Near You Ashburn VA change location
Brittney Mullins Ashburn, VA
Taylor Holt Ashburn, VA
Marlys Norby Alexandria, VA
ACE Fit Share
Watercress is prized in Asian cuisine for its peppery flavor and in this dish stands up to the sweet spiciness of the mussels in a coconut-laced red curry sauce. If you can find it in your market, use Thai basil for the garnish—it adds a unique sweet anise flavor that will make the dish taste all the more authentic.
Serves 4
Prep Time 40 min
Total Time 40 min.
Nutrition Profile: Diabetes Appropriate Healthy Weight Heart Healthy Low Calorie Low Carb Low Cholesterol Low Sat Fat Low Sodium
Step 1
Heat oil in a large high-sided skillet or Dutch oven over medium-high heat. Add garlic, scallion whites, lime zest and curry paste to taste; cook until fragrant and the paste is sizzling, 1 to 3 minutes. Add lime juice, coconut milk, brown sugar and fish sauce. Bring to a boil and let cook for 2 minutes.
Step 2
Add mussels, return to a simmer, cover and cook for 6 minutes. Spread watercress (or spinach) over the mussels, cover and cook until slightly wilted, about 4 minutes; stir into the mussels. (Discard any unopened mussels.) Serve garnished with scallion greens and basil.
Cranberry, Cherry & Walnut Marmalade
Athenian Orzo
Tabbouleh with Grilled Vegetables


text:
HEBRON UPDATE: April 30, 2002
April 30, 2002
HEBRON UPDATE: April 30, 2002
The Israeli occupation of the entire city of Hebron continued into its
second day as the city remained under curfew.
CPTers LeAnne Clausen and Greg Rollins spent the night at Al Mazan hospital
at the request of the hospital administrator, who was afraid that Israeli
soldiers might try to enter the building and harass the staff and patients.
Soldiers, however, did not come by.
On their way home from the hospital in the morning, Clausen and Rollins
watched Israeli soldiers arrest four Palestinian men and take them away in
an Armored Personal Carrier (APC).
Rick Polhamus and Anne Montgomery visited Alia hospital where staff told
them that the previous night had been quiet.
Polhamus and Rollins walked to the Israeli District Command Office (DCO) on
the outskirts of Hebron to inquire about Palestinians who had been arrested.
There, in the courtyard of the DCO, they saw about one hundred and fifty
Palestinians sitting on the ground in handcuffs, some wearing blindfolds.
When Polhamus asked an Israeli soldier how the Palestinians were being
processed, the soldier said the peoples' records were being checked and
those who had records would be further questioned by Israeli secret
police. Those that did not have records were released.
In the hour that the two CPTers were there they saw twelve Palestinians
released. All of them had papers stating that they had been detained and
released, but three Palestinian men said that the Israelis had arrested them
twice. Polhamus asked a soldier at the DCO about the re-arrests, and the
soldier admitted that
sometimes the soldiers who arrest people do not bother to look at these


text:
Software founder McAfee denies killing neighbor
SAN PEDRO, BELIZE (AP) - Software company founder John McAfee said Wednesday he is in hiding, unarmed and accompanied only by a young woman, changing locations and telephones frequently to stay one step ahead of a Belize police unit he says wants to kill him.
Belize police have said they want to question McAfee, who they describe as a "person of interest" in the slaying of fellow American Gregory Viant Faull. Faull, 52, was shot to death over the weekend on the Caribbean island where both men lived.
Prime Minister Dean Barrow said McAfee was only wanted for questioning and should report to authorities.
Barrow also expressed doubts about McAfee's mental state: "I don't want to be unkind to the gentleman, but I believe he is extremely paranoid, even bonkers."
McAfee, 67, who had a run-in with police earlier this year, told The Associated Press in a telephone interview from an undisclosed location that he didn't kill Faull, though he acknowledged he had differences with the dead man.
"I barely knew him, I barely spoke ten words to him in the last three years," McAfee said, speaking on a cellphone. "Certainly he was not my favorite person and I was not his."
"He was a heavy drinker and an annoyance. But the world is full of annoyances; if we killed all of our annoyances, there would be nobody left," McAfee said.
Other expat residents of the island of Ambergris Caye, where San Pedro is located, have described Faull, the owner of a construction business in Orlando, Florida, as peaceful and well-liked.
The dispute apparently involved several dogs that McAfee kept at his beachside villa and that drew complaints from neighbors. McAfee said that four of his dogs were poisoned late last week, but that he didn't initially suspect Faull of having killed them, though he knew Faull didn't like the dogs.
"He did threaten to shoot them once or twice," McAfee said of Faull, adding that his neighbor was "always angry at them."
But he said he now believes government agents or police poisoned the dogs.
"My assumption was it was some kind of government action again. This is more harassment - that was the first thing that went through my mind, and still is going through my mind. What else could it have been?" he said.
Faull was found with a gunshot wound to his head inside his two-story home north of San Pedro. The housekeeper discovered the body Sunday morning and called police.
Raphael Martinez, spokesman for Belize's Ministry of National Security, said no charges had been filed in the case, but urged McAfee to turn himself in, accompanied by someone else, if he felt safer that way.
But McAfee said he feared that Belize's notorious Gang Suppression Unit, the GSU, a paramilitary-style squad that has been accused of rough treatment and that raided another property McAfee owns in Belize in April, would beat him and he would later die in custody.


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Jill Zarin
Full name: Jill Zarin
Date of birth: November 30, 1963
Hometown: Woodmere, New York
Education: Simmons College School of Retail Management
Profession: Owner, Skweez Couture
Husband: Bobby Zarin
Children: One daughter, one stepson
Joined cast: Season 1
Left cast: Season 4 (fired)
Twitter: @Jillzarin
Jill Zarin may not be on The Real Housewives of New York anymore, but she's still rocking the glam lifestyle. Most recently, she launched the fall line of … more »
Never one to shy away from some healthy self-promotion, former Real Housewives of New York star Jill Zarin modeled a few pieces from her… more »
A lot has changed since Real Housewives of New York's first season.
With the Bravo reality series heading into its sixth season, Ramona… more »
Wow. Former Real Housewives of New York star Jill Zarin doesn't hold back when it comes to her opinion of the Kardashians, especially… more »


text:
Active substance: HYDROXYZINE HYDROCHLORIDE
View full screen / Print PDF » Download PDF ⇩
Atarax 10mg Film-coated tablets
Hydroxyzine hydrochloride 10mg Excipient(s) with known effect: Lactose (anhydrous) 47.3mg Sunset Yellow (E110) 0.24mg For the full list of excipients, see section 6.1
10mg film-coated tablets, coloured orange and coded on one side with AX.
Therapeutic indications
Atarax is indicated to assist in the management of anxiety in adults. Atarax is indicated for the management of pruritus associated with acute and chronic urticaria, including cholinergic and physical types, and atopic and contact dermatitis in adults and children.
Posology and method of administration
Method of administration: oral. Dosage: Anxiety Adults 50-100mg four times daily. Pruritus Adults: Starting dose of 25mg at night increasing as necessary to 25mg three or four times daily.
Use in the elderly: A reduced dose is advised. This is due to a possible increase in the volume of distribution, prolonged action and the possible effect of age-related changes on pharmacologic functions, including hepatic metabolism and renal excretion (see Section 5.2 Pharmacokinetic properties) Use in children: From 6 months to 6 years 5-15mg rising to 50mg daily in divided doses and for children over 6 years, 15-25mg rising to 50-100mg daily in divided doses. As with all medications, the dosage should be adjusted according to the patient's response to therapy. Hepatic impairment: The total daily dose should be reduced by 33%. Use in patients with severe liver disease should be avoided (see Section 4.4 Special warnings and precautions for use) Renal impairment: For patients with moderate or severe renal impairment, it is recommended that the total daily dosage should be reduced by 50% (see section 4.4 'Special warnings and precautions for use').
Atarax is contra-indicated in the following: patients who have shown previous hypersensitivity to hydroxyzine hydrochloride, cetirizine, other piperazine derivatives, aminophylline or ethylenediamine, or any of the excipients of Atarax (for a full list of excipients see section 6.1 List of excipients) asthmatics who have previously experienced a serious anti-histamine-induced adverse bronchopulmonary effect porphyria pregnancy and breast-feeding (see section 4.6 Fertility, pregnancy and lactation)
Contains lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Special warnings and precautions for use
Patients with hepatic impairment Due to its sedative properties, use of hydroxyzine should be avoided in severe liver disease due to an increased risk of coma, and in patients with hepatic failure due to possibility of hepatic encephalopathy. Hydroxyzine elimination is impaired in patients with hepatic dysfunction secondary to primary biliary cirrhosis. Dosage should be modified for patients with hepatic impairment (see Section 4.2 Posology and Method of Administration) Patients with renal impairment Atarax should be used with caution in patients with impaired renal function (see Section 4.2 'Posology and Method of Administration'). It is uncertain whether the drug may accumulate or have other adverse effects in such patients. Atarax is
completely metabolised and one of the metabolites is the active metabolite cetirizine. Cetirizine is renally excreted and clearance is reduced in patients with moderate renal impairment and on dialysis compared to normal volunteers. Elderly patients In elderly patients, it is recommended to reduce the dose of hydroxyzine due to a possible increase in the volume of distribution, prolonged action, and the possible effect of age-related changes on pharmacologic functions, including hepatic metabolism and renal excretion (see Section 4.2 Posology and Method of Administration and Section 5.2 Pharmacokinetic properties) Because of its potential antimuscarinic actions, Atarax should be used with caution in patients suffering from angle-closure glaucoma, urinary retention, prostatic hyperplasia, or pyroduodenal obstruction. Caution is required in patients suffering the following conditions: patients with a predisposition to cardiac dysrhythmias, with susceptibility to QT-interval prolongation or who are concomitantly treated with a potentially arrhythmogenic drug. All antihistamines should be screened for cardiotoxicity, as some patients may be poor metabolizers or may be susceptible to plasma concentrations near to the usual therapeutic range seizure disorders including epilepsy myasthenia gravis dementia decreased GI motility bladder outflow obstruction stenosing peptic ulcer patients with breathing problems (e.g. emphysema, chronic bronchitis) increased intraocular pressure hyperthyroidism cardiovascular disease hypertension Dosage adjustments may be required if Atarax is used simultaneously with other CNS depressants or with drugs having antimuscarinic properties (see section 4.5 Interaction with other medicinal products and other forms of interaction). The concomitant use of alcohol and hydroxyzine should be avoided (see section 4.5 Interaction with other medicinal products and other forms of interaction). Treatment should be stopped for one week before skin testing for allergy is undertaken, and for 96 hours prior to a methocholine test. Children and the elderly are more susceptible to side-effects. Patients should be warned of impaired judgement and dexterity. Atarax 10mg Film-coated tablets contain Sunset Yellow (E110) which may cause allergic reactions.
Interaction with other medicinal products and other forms of interaction
Atarax may have the following interactions: Methocholine test Treatment should be stopped for 96 hours prior to a methocholine test, to avoid effects on the test results (see section 4.4 'Special warnings and precautions for use') Treatment should be stopped at least one week before skin testing for allergy to avoid effects on the test results (see section 4.4 'Special warnings and precautions for use') Patients should be warned that Atarax may enhance their response to alcohol, barbiturates, benzodiazepines, hypnotics, opioids, anxiolytics, antipsychotics, antidepressents, antiemetics, antiepileptics, other antihistamines, skeletal muscle relaxants, sedatives, anaesthetics and other CNS depressants (see section 4.4 Special warnings and precautions for use) Antimuscarinic side effects (both peripheral and central) may be increased if Atarax is given with antimuscarinics such as atropine and some antidepressants (both tricyclics and MAOIs) (see section 4.4 Special warnings and precautions for use) Hydroxyzine has been shown to inhibit and reverse the vasopressor effect of adrenaline (see Section 4.9 Overdose) Additive anticholinergic effects may occur if hydroxyzine is administered concomitantly with other anticholinergic agents Hydroxyzine may antagonise the effects of anticholinesterase drugs Hydroxyzine may antagonise the effects of betahistine Cimetidine, 600mg twice a day, has been shown to increase the serum concentrations of hydroxyzine and to decrease peak concentrations of the metabolite cetirizine Hydroxyzine is an inhibitor of CYP2D6 and may cause drug-drug interactions with CYP2D6 substrates. Cetirizine does not interact with other drug substances via cytochrome P450 Drugs which have effects on the brain will interact with antihistamines Metabolism may be reduced in patients concomitantly receiving drugs that affect the hepatic microsomal enzyme system. Decreased metabolism may result in accumulation of potentially toxic concentrations of
Skin testing for allergy
CNS depressants
Anticholinergic agents
Anticholinesterase drugs Betahistine Cimetidine
CYP2D6 & cytochrome P450
Drugs which have effects on the brain Drugs that affect the hepatic microsomal enzyme system
Ototoxic drugs
Porter-Silber reaction or the Glenn-Nelson method
unchanged antihistamine It has been suggested that some sedating antihistamines could mask the warning signs of damage caused by ototoxic drugs such as aminoglycoside antibiotics Hydroxyzine has been reported to cause falsely elevated urinary concentrations of 17hydroxycorticosteroids when the Porter-Silber reaction or the Glenn-Nelson method is used
Fertility, pregnancy and lactation
Pregnancy Atarax should not be used during pregnancy (see section 4.3 Contraindications). Clinical data in humans are inadequate to establish safety in early pregnancy. The use of sedating antihistamines in the latter part of the third trimester may cause adverse effects in neonates such as irritability, paradoxical excitability, and tremor. Animal studies have shown reproductive toxicity. Foetal abnormalities have been reported when hydroxyzine was administered, at doses substantially above the human therapeutic dose, to the pregnant mouse, rat and rabbit. Hydroxyzine crosses the placental barrier which may lead to higher foetal than maternal concentrations.
The following events were observed in a neonate whose mother received high dose (600mg per day) hydroxyzine during pregnancy; hypotonia, movement disorders including extrapyramidal disorders, clonic movements, tachypnea and poor feeding. Lactation It is expected that Atarax may be excreted into breast milk. The effects on the nursing infant are unknown. Atarax should not be given to nursing mothers (see section 4.3 Contraindications).
Effects on ability to drive and use machines
Patients should be warned that Atarax may impair their ability to perform activities requiring mental alertness or physical co-ordination such as operating machinery or driving a vehicle. Concomitant use of hydroxyzine with alcohol or other CNS depressants should be avoided as this may aggravate these effects (see section 4.5 Interaction with other medicinal products and other forms of interaction).
Undesirable effects
The most common adverse effect of the sedating antihistamines is CNS depression. Effects vary from slight drowsiness to deep sleep, and include lassitude, dizziness, and incoordination. Paradoxical stimulation may occasionally occur, especially at high doses and in children and the elderly. If sedative effects occur, they may diminish after a few days of treatment. Other common adverse effects include headache, psychomotor impairment and antimuscarinic effects. Undesirable effects are listed by MedDRA System Organ Classes. Assessment of undesirable effects is based on the following frequency groupings: Very common: 1/10 Common: 1/100 to <1/10 Uncommon: 1/1,000 to <1/100 Rare: 1/10,000 to <1/1,000 Very rare: <1/10,000 Not known: cannot be estimated from the available data System Organ Class Blood and lymphatic system disorders
Immune system disorders Metabolic and nutritional disorders Psychiatric disorders
Undesirable Effect blood disorders, including agranulocytosis, leucopenia, haemolytic anaemia, and thrombocytopenia hypersensitivity reactions, anaphylaxis, angioedema porphyria, anorexia agitation, confusion, disorientation, hallucinations, sleep disturbances,
Frequency Not known
Not known Not known Not known
Nervous system disorders
depression, increased anxiety, nightmares dyskinesia4, insomnia, sedation, drowsiness, dizziness, weakness, headache, tremor1 convulsions2, psychomotor impairment, paraesthesias, extrapyramidal effects, seizure, coma, somnolence, disturbance in attention, involuntary motor activity3, ataxia, slurred speech, bitter taste in mouth, faintness accommodation disorder, blurred vision tinnitus, labrynthitis, vertigo tachycardia, palpitation hypotension, flushing bronchospasm, thickened respiratory tract secretions, wheezing, nasal stuffiness, dryness of throat constipation, dryness of the mouth, nausea, vomiting, increased gastric reflux, diarrhoea, epigastric pain, increased GI peristalsis liver dysfunction dermatitis, fixed drug eruption, pruritis, erythema, papular rash, sweating increased, urticaria, hair loss, eczema, acute generalised exanthematous pustulosis (AGEP) myalgia urinary retention, dysuria priapism, impotence, early menses fatigue, malaise, lassitude, pyrexia, dryness of respiratory mucosae, asthenia, tightness of chest, irritability, chills liver function tests abnormal
Not known
Eye disorders Ear and labyrinth disorders Cardiac disorders Vascular disorders Respiratory, thoracic and mediastinal disorders
Not known Not known Not known Not known Not known
Gastrointestinal disorders
Not known
Hepatobiliary disorders Skin and subcutaneous tissue disorders
Not known Not known
Muscoskeletal and connective tissue disorders Renal and urinary disorders Reproductive system and breast disorders General disorders and administration site conditions
Not known Not known Not known Not known
Investigations Footnotes
Not known
reported usually with doses considerably higher than those recommended. Continuous therapy with over 1g/day has been employed in some patients without these effects having been encountered
1,2, 3
dyskinesia may follow termination of prolonged antihistamine therapy.
Children and the elderly are more susceptible to side-effects.
Overdosage with sedating antihistamines is associated with antimuscarinic, extrapyramidal, and CNS effects. If CNS stimulation predominates over CNS depression, ataxia, excitement, seizures, tremors, psychoses, hallucinations, convulsions and hyperpyrexia can occur. Coma and cardiorespiratory collapse may follow. CNS stimulation is more likely in children and elderly. In adults, CNS depression is more common with drowsiness, postictal depression, coma, and convulsions, progressing to respiratory failure and cardiovascular collapse. In children and adults, cerebral oedema and upper nephron nephrosis, a deepening coma, tachycardia, QRS widening, heart block, cardiorespiratory collapse/arrest, cardiogenic shock, and death may occur. Common features include excessive sedation, nausea, vomiting, flushing, dilated pupils, dry mouth and tongue, hot dry skin, fever, sinus tachycardia, hypertension, ataxia, nystagmus, delirium, agitation, psychosis and visual hallucinations. Uncommon systemic features include myoclonic jerking, muscle rigidity, coma, convulsions, cardiac conduction abnormalities, QT prolongation and arrhythmias, cardiovascular collapse, paralytic ileus, urinary retention, hyperkalaemia, metabolic acidosis and rhabdomyolysis. Peak concentrations occur approximately two hours post ingestion, and elimination half-life has been reported approximately 14 hours and 20 hours post ingestion (see section 5.2 Pharmacokinetic properties). There is no specific antidote. It is doubtful whether haemodialysis or peritoneal dialysis has any value in the treatment of overdosage with Atarax. However, if other agents such as barbiturates have been ingested concomitantly, dialysis may be indicated. Consider activated charcoal only if the patient presents within 1 hour of ingestion of a potentially toxic amount. Gastric lavage is rarely required; for substances that cannot be removed effectively by other means, it should be considered only if a lifethreatening amount has been ingested within the previous hour. It should be carried out only if the airway can be protected adequately. Induction of emesis is not recommended. General supportive care, including frequent monitoring of the vital signs and close observation of the patient is indicated. Clear airways should be maintained, and there should be adequate ventilation. Assisted ventilation is indicated if hypercapnia is present. Observation for 6 hours after ingestion, without any other specific treatment, will be sufficient for the majority of patients. Monitor BP, pulse and body temperature. In symptomatic patients measure U&Es and creatine kinase. Perform a
12-lead ECG and monitor cardiac rhythm. Patients who have been unconscious may be hypothermic. Hypotension, though unlikely, may be controlled with intravenous fluids. In adults, if severe hypotension persists, determine the cause and consider treatment with the following; if hypotension is mainly due to decreased systemic vascular resistance, drugs such as noradrenaline or high dose dopamine may be beneficial, if hypotension is due to reduced cardiac output dobutamine, or in severe cases adrenaline may be beneficial. However it should be noted that hydroxyzine has been shown to inhibit and reverse the vasopressor effect of adrenaline. Analeptic agents should not be used since they may cause seizures. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken.
Pharmacodynamic properties
Pharmacotherapeutic group: Anxiolytics ATC code: N05B B01 Atarax is unrelated chemically to benzodiazepines, phenothiazines, reserpine and meprobamate. Mechanism of action Hydroxyzine is a first generation antihistamine, a piperazine derivative, with antimuscarinic and sedative properties. Antihistamines act as competitive antagonists of histamine at H1 histamine receptors, thus inhibiting H1 receptor-mediated reactions, such as vasodilation, flare and itch reactions and sneezing. First-generation H1 antagonists easily cross the blood-brain barrier, consequently producing well-documented sedative and anticholinergic effects. First-generation antihistamines also have affinity for 5-HT receptors, alphaadrenoreceptors, and muscarinic receptors. They also reduce cyclic GMP concentrations, increase atrioventricular nodal conduction, and inhibit activation of airway vagal afferent nerves. Pharmacodynamic effects Hydroxyzine has CNS depressant, anticholinergic, antispasmodic, and local anaesthetic activity, in addition to antihistaminic effects. The drug also has sedative, antiemetic and primary skeletal muscle relaxant activity.
An onset of sedative action of hydroxyzine is usually noted within 15 to 30 minutes after oral administration. Sedative effects persist for 4-6 hours following administration of a single dose. Hydroxyzine suppresses the inflammatory response (wheal and flare reaction) and pruritus for up to 4 days after intradermal skin tests with allergens and histamine. The therapeutic range for plasma hydroxyzine concentrations and the relationship of plasma concentration to clinical response or toxicity have not been established. Hydroxyzine does not appear to increase gastric secretions or acidity, and usually has mild antisecretory effects. It induces a calming effect in anxious tense adults. It is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of the subcortical area of the central nervous system. Clinical efficacy and safety Atarax has been shown clinically to be a rapid-acting anxiolytic with a wide margin of safety. Antihistamine effects have been demonstrated experimentally and confirmed clinically; it is highly effective in alleviating pruritus. Paediatric population The pharmacokinetics and antipruritic effects of hydroxyzine were studied in 12 children (mean age 6.1 +/- 4.6 years) with severe atopic dermatitis, each given a single 0.7 mg/kg oral dose. Pruritis was significantly suppressed from 1 to 24 hours after the administration of the dose, with greater than 85% suppression from 2 to 12 hours. The potent antipruritic effect persists even when serum concentrations of the drug are low (only 10% of the maximum levels achieved). In children, the biologic effects of hydroxyzine appear to be much more prolonged than would be predicted from the half life values. 5.2 Pharmacokinetic properties
Absorption Hydroxyzine is rapidly absorbed from the gastrointestinal tract. After a single oral dose of hydroxyzine, 0.7 mg/kg (mean dose 39.0 +/- 5.4 mg) a mean maximum serum hydroxyzine concentration of 72.5 +/- 11.1 ng/ml has been shown to occur at a mean time of 2.1 +/- 0.4 hours. Distribution Distribution of hydroxyzine into human body tissues and fluids has not been fully characterised. Following administration of hydroxyzine to animals, the drug is widely distributed into most body tissues and fluids with highest concentrations in the liver, lungs, spleen, kidneys, and adipose tissue. The drug is also distributed into bile in animals.
Hydroxyzine crosses the placental barrier which may lead to higher foetal than maternal concentrations. Serum hydroxyzine concentrations do not necessarily reflect hydroxyzine tissue binding or distribution to skin receptor sites. Suppression of wheals, flares, and associated pruritis has been shown to persist even when serum hydroxyzine concentrations are low. First-generation H1 antagonists easily cross the blood-brain barrier. In a study group of healthy adults, the mean apparent volume of distribution has been found to be 16.0 +/- 3.0 L/kg. Biotransformation Hydroxyzine is metabolised in the liver. Metabolites include cetirizine, which has antihistaminic activity. Cetirizine is formed from hydroxyzine via an oxidative biotransformation step. Elimination An elimination half life of 20.0 +/- 4.1 hours and of 14.0 hours has been reported for hydroxyzine. Total body clearance in adults is generally in the range of 5 to 12 ml/min/kg. Hydroxyzine is eliminated by hepatic metabolism in humans. Cetirizine is mainly renally excreted. Special populations Elderly patients The pharmacokinetics of hydroxyzine were studied in nine healthy elderly (mean age 69.5 +/- 3.7 years) subjects who ingested a single dose of hydroxyzine, 0.7 mg/kg (mean dose 49.0 +/- 6.7 mg). The mean serum elimination half life value of hydroxyzine in this elderly group was 29.3 +/-10.1 hours (range 20.2 to 53.3 hours), which was significantly longer than that reported in younger subjects. The mean apparent volume of distribution of hydroxyzine in this elderly group was 22.5 +/- 6.3 L/kg (range 13.4 to 30.7L/kg), which was significantly larger than that reported to be found in young adults. Hydroxyzine has a long mean serum elimination half life value, a large volume of distribution and a prolonged pharmacodynamic effect (suppressive effect on wheal and flare response to histamine) in the elderly. In the elderly a number of age-related biological and physiological changes may have an effect on the pharmacology of hydroxyzine and its metabolite, cetirizine. These changes may impact upon the pharmacologic functions of absorption, distribution, metabolism, excretion, and receptor sensitivity. Dosage reduction may be appropriate in elderly patients (see section 4.2 Posology and Method of Administration)
Paediatric patients The pharmacokinetics and antipruritic effects of hydroxyzine hydrochloride was studied in 12 children aged 1 to 14 years (mean age 6.1 +/- 4.6 years) with severe atopic dermatitis. The children were given a single orally administered dose of 0.7 mg/kg hydroxyzine. The mean peak serum concentration of 47.4 +/- 17.3 ng/ml occurred at a mean time of 2.0 +/- 0.9 hours. Terminal elimination half life was shorter in children than in adults, at a mean of 7.1+/- 2.3 hours. This resulted from a larger clearance rate in children of 32.08 +/- 11.05 ml/min/kg. The elimination halflife values increased with increasing age. Half life values were approximately 4 hours in the 1 year old patients and 11 hours in the 14 year old patient. Dosage should be adjusted in the paediatric population (see section 4.2 Posology and Method of Administration) Hepatic impairment The pharmacokinetics and pharmacodynamics of hydroxyzine were studied in eight patients (mean age 53.4 +/- SD11.2 years) with primary biliary cirrhosis, given a single dose of 0.7 mg/kg (mean dose 43.9 +/- 6.6mg) hydroxyzine. All patients had abnormal liver biochemistry tests, all had biopsies compatible with primary biliary cirrhosis, and seven of eight had positive tests for antimitochondrial antibodies. Hydroxyzine elimination was found to be impaired in patients with primary biliary cirrhosis. Mean peak hydroxyzine levels occurring at 2.3 +/- 0.7 hours were found to be 116.5 +/- 60.6 ng/ml, which was significantly higher than in other patient groups studied previously. Mean serum elimination half-life of hydroxyzine was 36.6 +/13.1 hours, which was significantly longer than in patients with normal hepatic function studied previously. Dosage should be adjusted in patients with hepatic impairment (see section 4.2 Posology and Method of Administration)
Renal impairment The pharmacokinetics of hydroxyzine and of its active metabolite cetirizine were studied in patients with reduced kidney function. Eight healthy volunteers and eight patients with renal insufficiency received a single peroral dose of 50 mg hydroxyzine. With regards to hydroxyzine, results showed moderate elevation of the average terminal half-life in the patients group (t1/2 14 vs. 23 h). The areas under the concentration-time curves (AUC) were 996 nghml-1 in the healthy volunteers group and 1621 nghml-1 in the patients group. For cetirizine, AUC measured 6036 nghml1 in the healthy volunteers group and 31635 nghml-1 in the patients group. The study concluded that the reduced renal clearance of cetirizine may be of clinical importance in patients with renal failure. Dosage should be adjusted in patients with renal impairment (see section 4.2 Posology and Method of Administration)
Preclinical safety data
None stated.
List of excipients
Tablet core: Lactose anhydrous Calcium Phosphate Dibasic Anhydrous Pregelatinised Starch Magnesium Stearate Sodium Lauryl Sulphate Silicon Dioxide Tablet coating: Opadry II Orange 85G23730 (10mg only) contains: Poly (vinyl alcohol) Talc Macrogol 3350 Sunset yellow (E110) Titanium dioxide (E171) Iron oxide yellow (E172) Quinoline yellow (E104) Lecithin (E322).
Incompatibilities Hydroxyzine hydrochloride has been reported to be incompatible with aminophylline, benzylpenicillin salts, chloramphenicol sodium succinate, dimenhydrinate, doxorubicin hydrochloride (in a liposomal formulation), thioridazine, and some soluble barbiturates.
Shelf life
24 Months.
Special precautions for storage
Do not store above 25C.
Nature and contents of container
White opaque 250/51 micron PVC/PCTFE - 20 micron aluminium foil blister strips containing 84 x 10mg tablets, (6 blister strips per carton)
Special precautions for disposal
No special requirements.
Alliance Pharmaceuticals Ltd., Avonbridge House, Chippenham, Wiltshire, SN15 2BB, UK.
27/04/1987 / 11/07/2003
Source: Medicines and Healthcare Products Regulatory Agency
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