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Equity Diversity Interdependence
Promoting a Peaceful and FairSociety based on Reconciliationand Mutual Trust.
Contact: Andrée Murphy
39 Glen Road
Tel: 028 9062 7171
E-Mail: firstname.lastname@example.com
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To provide a safe space for the bereaved and injured of the conflict to meet together to address their experiences and to support the recovery of health and wellbeing;To provide appropriate and development based individual, family and group support for the bereaved and injured. Where appropriate Relatives for Justice will deliver this in partnership with other organisations;To support the bereaved and injured to tell their story and document their experiences;To build awareness and foster an understanding of the specific experiences of the bereaved and injured of the conflict. In doing so to contribute to a culture of human rights;To support families engaging with relevant legal professionals and government bodies. Support families with cases relating to their bereavement and/or injury giong through domestic and international courts;Liaise with international human rights, NGOs, Government bodies and other international organisations bringing to their attention many of the circumstances surrounding incidents in which people have been injured or killed.
Family Support - befriending, counselling and therapy for individuals and families to support them come to terms with traumatic experiences and to restore their health and wellbeing.Developing appropriate models of therapeutic interventions and ways of working to support the individual and community to recover wellbeing in the aftermath of armed conflict, including examining and adopting appropriate international models of recovery.Design and publish information to promote education, greater awareness, and understanding of the experiences and issues of the bereaved and injured of the conflict.Establish an archive of historical material that documents the experiences of the bereaved and injured of the conflict and the work of Relatives for Justice.To highlight state injustice and to work toward repealing legislation that prohibits the truth from emerging and ending anonymity to perpetrators of violence and impunity.Liaise with international human rights NGOs to highlight the circumstances surrounding incidents in which people have been injured or killed by state actions where truth, justice and accountability have not been secured.Provide advice and guidance: accessing services; sign posting agencies and support during legal and other cases.Working for retrospective justice for the bereaved and injured of state and state sponsored actions.Develop the regional structures of Relatives for Justice in order to further strengthen the growth and development of locally based groups by building capacity, confidence and skills.Provide high quality support and training to staff members and volunteers.


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Job-hunting ItemsThe following is a partial list of subjects to be discussed in further detail at a later date. Note that this section will be updated on a periodic basis:
Indicated below are some very interesting articles that can assist you in you job hunt.
Entering the Job Search Zone - Linda Scharf, CPC Things are going well at work. You have created your niche and are proud of your accomplishments. Yet now the comfort of the familiar has turned to boredom and you say to yourself, " Been there. Done that." You have just entered the JOB SEARCH ZONE. This is where it begins ---the journey from the familiar to the exciting world of change. To survive in the ZONE you will need protective gear. You will need to be prepared to describe who you are, what you have accomplished, and what separates you from the crowd. Develop a strategic plan and get ready for action: Organize your thoughts by creating lists: Once you have reviewed and analyzed your past its time to think about your future: What are your immediate goals? Where do you hope to be in 3-5 years? What about your 5-10 year plan? Employers seeking support and administrative employees are generally most interested in your immediate goals. If you are on a middle or upper management level be prepared to discuss your long-term goals. Everything you have just done will help you prepare a resume and express yourself with confidence at an interview. You are now prepared to enter the JOB SEARCH ZONE. Proceed with enthusiasm. Change is enriching and exciting! ------------------------------------------------------------------------------------------ Linda Scharf, CPC, is President of Judlind Employment Services, Inc. in Stamford, CT. Judlind specializes in permanent, temporary and tempto-hire staffing for office support, administration, accounting and finance. REPRINTED WITH PERMISSION [ Home ] [ Top of Page ] Crafting your Net for Networking - Linda Scharf, CPC Networking is a 24-hour process. It is a lifestyle that enhances business and personal relationshipsa support system that will help you when you need a new job, advise on climbing the corporate ladder, a safety net when you dare to "go it alone," a resource when you need a doctor, personal trainer or child care provider. Every person you meet has the potential of adding value to your network. Soput yourself where the people are: community center, business organizations, religious and community volunteer organizations, adult education and college classes, health clubs, bookstores, special interest groups. Join groups you enjoy. Get involved. Participate on a committee. Attend all the monthly meetings. Take a series of classes. The key is to be involved with a group on an ongoing basis so that you can get to know people. Once you target a group attend the next scheduled meeting. Be pro-active and engage people in friendly small talk. Approach people who are by themselves rather than trying to inch your way into a group. Introduce yourself and start with pleasant open-ended conversation: "What made you decide to come tonight?" "What do you know about the speaker?" "Are you a member or a guest tonight?" Draw the person out and build it into a conversation. Presto! Youre crafting your net! Get organized and create a "network file". Keep notes on each persons phone number, address, and areas of interest and professional expertise. Networking nets need constant care. Nurture the relationship by keeping in touch. Send a note or article of interest; pick up the phone and call. Be sure to connect with that person at the next meeting, class or event. Be available when they need help so that they will be available for you when you need help. Remember that networking is a continual process. You need to be willing to be pro-active and push yourself to meet new people and engage them in conversation. Networking is a challenge that enhances your life. ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ ¨ REPRINTED WITH PERMISSION [ Home ] [ Top of Page ] |

subset: commoncrawl


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Closing costs are way too expensive.
TRUTH: First of all, HUD regulates all fees associated with obtaining a reverse mortgage and most of these fees can be financed into the loan. One-half of the closing costs consist of a mortgage insurance premium paid to HUD for the FHA insurance on the reverse mortgage. If one were to compare the fees with the cost of selling the home (agent commissions, etc), a reverse mortgage is a great savings and the senior homeowner gets to stay in their home. Update: Just recently, many lenders are now waiving their origination and servicing fee's, reducing the cost to the consumer considerably. Never has the program been so affordable and there hasn't been a better time to consider a reverse mortgage.


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Friday, December 20, 2013
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Some Manhattan subway riders could be in for a surprise when they arrive at their subway stations Thursday morning.
Members of the Transport Workers Union Local 100 will be at several stations handing out mock MetroCards that have fake blood on the front and the Grim Reaper on the back.
It's part of the union's campaign to get train operators to slow down before entering the station, which they say would cut down on rider deaths.
The union has also been calling to put MTA agents on crowded subway platforms and emergency power shutoff switches at all station booths.
The MTA says that slowing down trains would only increase crowding at the stations and make them more dangerous.
While 55 people were killed by trains last year, the agency compares that figure to the 1.64 billion subway rides taken.
The MTA says it wants to work with the union on a public education campaign to keep people from standing on platform edges.
Do you have a news tip or story idea about the city's transit systems? Send an email to NY1 Transit Reporter Jose Martinez.


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Handspring, a maker of electronic organizers, agreed to buy the closely held Bluelark Systems in a stock deal worth about $16.1 million to add wireless Internet access to its products. Handspring will exchange as many as 450,000 shares of its stock for Bluelark, a company spokesman said. Shares of Handspring fell 19 cents, to $35.88.
December 27, 2000
Technology Briefing | Hardware: Handspring Raises Cash
Handspring Inc., the money-losing maker of the Visor hand-held computer, said it had raised $48.5 million from investors including Qualcomm Inc. Qualcomm, which licenses patents for a technical standard used in 96 million mobile phones, bought 1.84 million shares from Handspring for $10 million, or about $5.44 each. Handspring also sold seven million shares to the public at $5.50 each, raising $38.5 million. Handspring's shares rose 89 cents, or 14.5 percent, to $7.01. The money could help ease concern that Handspring will...
December 20, 2001
Handspring Launches Rival to Palm Pilot
Handspring Inc. introduced a hand-held computer today that its says costs less and does more than the best-selling Palm Pilot, the 3Com Corporation's electronic organizer that Handspring based its new model on. Handspring's device, called Visor, costs $149 to $249 and looks like 3Com's Palm Pilot. The most notable difference is a slot for cartridges that can hold software or turn the Visor into a two-way pager or digital-music player. The Visor is the fruit of an effort by the inventor of the Palm Pilot, Jeffrey Hawkins, and...
September 15, 1999
Handspring's Share Price Jumps 35% in First Day of Trading
Shares of Handspring Inc. rose 35 percent in their first day of trading today after raising $200 million in an initial public offering that showed investors' enthusiasm for companies that make increasingly popular hand-held computers. The company's stock rose $6.9375, to $26.9375 a share, as more than 12 million shares were traded, giving the company a market value of $3.4 billion. Handspring sold 10 million shares -- an 8 percent stake -- at $20 each on Tuesday. Investors are hoping the two-year-old company,...
June 22, 2000
Handspring Inc., which makes handheld computers similar to the ones from Palm Inc., filed yesterday to sell up to $300 million of common stock in an initial public offering. The terms of the offering were not disclosed in the filing with the Securities and Exchange Commission. The Mountain View, Calif., company was founded by Donna Dubinsky and Jeff Hawkins, the original developers of the first Palm computer. Their Visor line of handhelds uses the Palm operating system under license.
April 1, 2000
Handspring Finds More Fits, Fewer Starts in Visor Delivery
HUNDREDS of people who were among the first to order the new handheld Visor, a Palm Pilot-like digital assistant, are still waiting for the U.P.S. truck. A few dozen disgruntled customers have congregated at an independent Web site called visorcentral .com to vent their frustration. Some have canceled their orders; others are just plain angry at Visor's maker, Handspring, a flashy Silicon Valley start-up. Handspring, well aware of the problems, has posted an apologetic letter on its Web site,...
November 4, 1999
NEWS WATCH; New Programs in the Works For Handspring's New Visor
The Visor, Handspring's new competitor to the Palm Pilot, will depend on independently developed programs and devices -- everything from MP3 players to exercise monitors -- that will fit in the Visor's expansion slot, called the Springboard. Most of the modules will not be available until early next year. However, several should be available during the holiday buying season. Concept Kitchen has developed a series of city guides, City Sync, based on the Lonely Planet series of travel guides.
October 14, 1999
Palm's Marriage Of Convenience To Handspring Shows Promise
Todd Bradley, PalmOne's president and chief executive, recalls meetings last year with product designers of the company's predecessor, Palm Inc., to work out details of their next line of hand-held computers. With the market taking off for cellphones that could do more than receive calls, while demand shrank for the stand-alone hand-held devices that were their specialty, the executives knew that Palm's future depended on quickly introducing the right product. The next move would be...
February 23, 2004
Technology Briefing | Hardware: Palm And Handspring Win Patent Suit Filed By NCR
Palm Inc. and its smaller rival Handspring Inc. did not infringe patents for a hand-held computer system owned by NCR, a federal judge ruled yesterday. The judge, Kent A. Jordan at Federal District Court in Wilmington, Del., upheld a finding by a magistrate in July 2002 that the two makers of hand-held devices did not rely on technology patented by NCR for a personal terminal. Palm said in June that it agreed to buy Handspring for about $168.9 million in stock. NCR, the largest seller of automated...
August 29, 2003
When Palm Does a Deal, Prices Get Crazy
THAT is it about Palm Inc. that produces irrational prices? When Palm agreed to rescue Handspring on Wednesday, the deal amounted to a takeunder, in which Palm offered stock worth less than Handspring was trading for. But Wall Street did not seem to notice, and Handspring traded that day for more than the value of the stock its shareholders will receive. Judy Bruner, Palm's chief financial officer, took it in stride. "We had the same kind of market irrationality when Palm was spun off from 3Com," she recalled on...
June 6, 2003
NEWS WATCH: HAND-HELDS; New Visors Have Buyers Hunting High and Low
Handspring has done something about the confusing array of hand-held computers on the market: they've added to it. The company has announced two new Visor hand-helds, one aimed at the high-end business user and the other at the entry-level consumer. The standard Visor Pro comes with 16 megabytes of RAM (up from 8 megabytes for most high-end Visors) and a 33-megahertz Motorola Dragonball chip that offers double the speed of earlier models. The Visor Pro also uses a rechargeable battery...
September 20, 2001
NEWS WATCH; A Cell Phone That Fits On the Back of an Organizer
Ever since the hand-held organizer joined the cell phone as a must-have gadget, the electronics industry has been trying to figure out how to combine the two. They would seem to make a good fit: organizers can carry loads of data -- calendars, contact numbers, to-do lists -- and the cell phone is the perfect tool to put it all to use. Besides, who wants to carry two devices if one will do? But early efforts at combining phones and organizers have been less than a grand success.
December 28, 2000
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Laurel Festival of the Arts officials began their 1992 fund-raising season yesterday assured that if they collect $10,000 from residents and businesses an additional $5,000 is guaranteed.
The $5,000 is a challenge grant from the Horsehead Community Development Fund in Palmerton.
Meanwhile, Harry Hintz, a festival leader, announced yesterday that the third annual arts and music celebration will open with a concert June 13 and will run through June 28 in Jim Thorpe.


text: Introduction Some genes in metazoan genomes appear to follow a 'one-gene, one-transcript, one-protein' rule. However, transcription at most gene loci generates a diversity of alternate transcripts (isoforms) by the use of alternative transcription initiation, splicing and polyadenylation sites (collectively referred to as alternative expression or 'AE' events). Figures 1 and 2 briefly outline the process of gene transcription and enumerate some of the categories of alternative transcription events. Early efforts to study the transcriptional diversity of genomes have focused on the use of a variety of sequencing technologies and the application of new sequencing platforms to this area continues. These technologies are summarized briefly in Figure 3. cDNA and Oligonucleotide microarrays have also been suggested as a means of studying alternative transcription patterns across tissues and developmental stages as well as in disease models. The development of expression microarrays towards this end is summarized in Figure 4. The idea of using 'splicing' microarrays consisting of exon-junction and other probe configurations to detect such alternative transcription events was first suggested by Douglas Black (Black, 2000). Since 2002, a number of groups have begun to experiment with arrays capable of measuring mRNA expression at the level of AE events (early efforts were reviewed by (Lee and Roy, 2004)). A number of works have specifically addressed the theoretical and practical issues of designing custom splicing microarrays to detect AT events by conducting proof-of-principle experiments in a variety of metazoan species (Srinivasan et al., 2005; Castle et al., 2003; Clark et al., 2002; Johnson et al., 2003; Stolc et al., 2004; Pan et al., 2004). Additional studies have focused on developing analysis methods for the data generated from these arrays: Splicing index values (Clark et al., 2002 ; Li et al., 2006), ASAP (Le et al., 2004), splice and neighborhood algorithms (Fan et al., 2006; Hu et al., 2001), ANOSVA (Cline et al., 2005), sequence based splice variant deconvolution (Wang et al., 2003) and GeneASAP (Shai et al., 2006). Finally, a small number of experiments have used these arrays for the study of particular biological questions (Relogio et al., 2004; Li et al., 2006; Zhang et al., 2006; Sugnet et al., 2006; Ule et al., 2006; Blanchette et al., 2005; Ule et al., 2005) Figures 1-4 shown below are taken from the following book chapter which contains a complete discussion of this topic: Alternative expression analysis: experimental and bioinformatic approaches for the analysis of transcript diversity. Malachi Griffith and Marco A. Marra. Genes, Genomes, and Genomics. Vol. 2. 2007. Regency Publications. New Delhi. The ALEXA Platform The purpose of the computational platform described in the publication (Griffith et. al. 2007) is to facilitate the use of custom microarrays for the study of alternative transcription events. Although a number of publications have described the use of such arrays the designs are generally not readily available and have only been created for select species. ALEXA offers the capability to generate custom arrays for most EnsEMBL species and provides a design that is annotated to the level of genes, transcripts, exons, and individual probes. The platform itself consists of Perl and R scripts and modules, a mySQL relational database and an associated API for interacting with the database. This platform takes as input, a complete set of EnsEMBL gene models for a single species and generates a complete set of probes corresponding to the exons, introns, exon-junctions and exon-boundaries of these genes. Figure 5 depicts the selection of probe sequences from a single gene. These probes are then scored and filtered according to their specificity and thermodynamic properties. Finally, in addition to the platform, pre-computed designs are provided for several EnsEMBL species. Since the design process is computationally intense, it may be desirable to use these designs directly. They may also be used as guides for those who wish to create their own design. Figures Figure 1. Gene transcription and RNA processing Expression of a typical protein-coding gene involves: gene transcription, pre-mRNA processing and polyadenylation. Each of these processes is regulated by components of the transcription machinery which recognize sequence motifs in the DNA template and pre-mRNA molecule. After pre-mRNA processing, the mRNA is exported to the cytoplasm where ribosomes translate it into protein. Abbreviations: (UTR) untranslated region; (D) donor site; (A) acceptor site; (SS) splice site; (ESE) exonic splicing enhancer; (ESS) exonic splicing silencer; (ISE) intronic splicing enhancer; (ISS) intronic splicing silencer. Figure 2. Types of alternative expression (AE) Gene models are depicted as exons (colored rectangles) connected by introns (black lines). Green arrows indicate transcription initiation sites, dotted lines indicate splicing patterns and polyadenylation sites are denoted as 'poly (A)'. The mRNA products generated by each type of AT are shown to the right of each gene model. Simple transcription is contrasted with alternative transcript initiation, the five major classes of alternative splicing, and alternative polyadenylation. In each model, yellow exons are constitutive and blue exons are alternative. Figure 3. Sequence-based methods for profiling transcript diversity Hypothetical transcript sequences consisting of exons (green rectangles) with intervening introns (black lines) are depicted as gapped alignments to a reference genome. The following tracks represent sequences generated by each sequence-based method. Human genes have an average of 10 exons with an average length of 250 bp. The methods are displayed in order of least to most quantitative. Abbreviations: (EST) expressed sequence tag; (SAGE) serial analysis of gene expression; (CAGE) capped analysis of gene expression; (GIS) gene identification signature. Figure 4. Microarray based methods for profiling transcript diversity Gene models are depicted as exons (colored rectangles) connected by introns (black lines). Hypothetical differences in mRNA products which can be detected by each array method are depicted to the right of each gene model. In each model, yellow exons are constitutive and blue exons are alternative. Differences in array design strategy, particularly the position and types of oligonucleotide probes used are shown above each gene model as colored horizontal lines. Figure 5. ALEXA array design strategy Diagram illustrating the concept of oligonucleotide probes in an ALEXA design. Shown is a cartoon of a gene with five differently colored exons separated by introns. For this gene there are 10 possible exon-exon junctions. In general, there are (n!/[[n-2]!2!]) possible exon junctions, where n is the number of exons in a gene. For each gene, oligonucleotide probes are also designed to represent the ([n×2]-2) exon-intron junctions. Probes contained within the boundaries of each exon and intron are also selected In this hypothetical example 27 oligonucleotide probes would be designed. |


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Macworld USA – August 2012-P2P
Macworld Magazine since its inception in 1984, the Macintosh has been pioneering the world of computers. And Macworld magazine keeps you abreast of the continuing computer developments being made by the Mac. Macintosh users can rely on Macworld's incisive product reviews, in-depth feature, articles, technical pointers, buying tips and Labs-based performance reports. With specialized up dates on desktop publishing, graphics, connectivity and telecommunications.
Macworld USA – August 2012-P2P
English | HQ PDF | 100 Pages | 68 MB
SiNGLE FiLE DOWNLOAD


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sporterized krag??? I bought it!!!!!!!!
V.I.P. Member Posts: 96 (8/19/02 11:24:24 am) Reply | Edit | Del All sporterized krag??? I bought it!!!!!!!! -------------------------------------------------------------------------------- My local gun shop picked up a sporterized Krag rifle. Asking prices is $200 firm. Do you guys think that is too much for a sporterized Krag. The stock has been cut down, and the fron sight has been replaced with a sporter front sight, oh yeah the barrel has been shortened. Look pretty decent, and i don't have a krag. I have been kicking the idea around in my head, but wanted to know what you guys thought. Edited by: mauserman454 at: 8/21/02 10:12:08 am Moskovskyya V.I.P. Member Posts: 153 (8/19/02 4:16:42 pm) Reply | Edit | Del Re: Should I buy this sporterized krag??? -------------------------------------------------------------------------------- No, tell me where it is so that I can buy it! Or easier than that, buy it, but then suddenly determine that it doesn't enhance your collection, and out of the goodness of your heart give it to me to enhance my collection. TallTLynn *TFF Senior Staff* Posts: 4465 (8/19/02 7:23:48 pm) Reply | Edit | Del ezSupporter Re: Should I buy this sporterized krag??? -------------------------------------------------------------------------------- Buy it! And don't give it to our friend over here - he's got more stuff than he knows what to do with anyway mauserman454 V.I.P. Member Posts: 98 (8/20/02 6:19:23 pm) Reply | Edit | Del Nope, can't have it mosk!!!! -------------------------------------------------------------------------------- I bought the Krag!!!!! I paid the $200 buck for it. My dad says its an original carbine barrell. He says he can tell because that is the origanal front sight on a 21" barrell. I am posting a pic, what do you guys and gals think. Is that the original front sight??? Somebody butcherd the stock, and cut the rear of the barrell for a dovetail williams rear sight. Gunparts lists a new reproduction carbine stock, which I will buy, but doesn't list the rear sight. Anyone happen to have an original krag rear sight they will sell me. By the way, the bore is in very good condintion, with only the slightest traces of pitting. Edited by: mauserman454 at: 8/20/02 7:19:56 pm |
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I've just launched my new website for personal property appraisal (one item to full estates) which also links to my bookstore. Love to talk to you about any appraisal needs, books in our inventory or…Continue
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With the fall speeding by faster then I can cross the days off my calendar, I started to think today about ways to promote my business and leverage my marketing during the holiday shopping season.…Continue
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Use coupon B684699-CWW.http://www.biblio.com/bookstore/chrysalis-books-new-yorkStart holiday shopping now! Also, let me know if…Continue
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HI Tenille
Just wanted to say welcome and introduce myself
Hi Tenille with the interesting name,,
I am delighted that you have joined the two largest and featured groups: "The Pen Is Mightier Than the Sword" and now "Communication Is the Key"!
You may wish to comment ON EACH SITE introducing yourself to the group and sharing what you may contribute and what you may possibly gain through participation.
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Thank you for your support. I too have a love for books, have some dated from the 1800's, but they are not of the genre you focus on - found in thrift stores...I check the internet regarding their value. I wish you much success here and at your store.
Welcome, Tenille!
My first husband was an antiquarian book dealer!
I also spent 60 years in New York.
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Which avatar should sinista have? (Not that you have to change it sinista)
I have to admit that I liked the penguin with the board under his arm.
Guess who's got some more free time on his hands.
How to escape a rip current? RELATED: Surfing Lessons For All Author: ElenaPVR Replies: 14 |
The Sinista Penguin Respray Project! RELATED: General Chat Author: sinistapenguin Replies: 40 |
Liquid Peace - Current Low Low Prices RELATED: Surf Shop Sales, Online Special Offers & Coupons Author: surf patrol Replies: 0 |
current viewers? RELATED: Forum & Main Site Feedback Author: IB_Surfer Replies: 1 |
Christmas Avatar's RELATED: General Chat Author: Farno Replies: 17 |


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(08) 9328 7464 10am – late
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Become a Member
Sign up to the Planet website and you'll never forget which movies and games you wanted to rent, ever again!
Welcome to Trona, California – a dead end desert town for people with dead end lives. And no one is going nowhere faster than Ray Tuckby (Dylan Walsh from TV's Nip/Tuck), a mild mannered parking lot attendant saddled with a neurotic shut-in wife and an ill mannered, sexually frustrated son (Johan Hill from Superbad). That is, until Ray's life totally bottoms out. Now, with the help of a childhood sweetheart and a concerned stranger (Danny Devito), Ray is about to take back his life – and his town – in this offbeat comedy that proves it's never too late to grow – even if you're all grown up.


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Locally owned and located in beautiful downtown Colorado Springs, Colorado, Lady Godiva has been serving the Colorado Springs area for over five years. We love what we do and it shows. From our warm and welcoming environment, to our outstanding service, you will be surrounded by artistically inspired people that have a true passion for our industry. Partnered with the power of John Paul Mitchell Systems, an industry leader for over thirty years, you are sure to have a truly wonderful and exciting experience. So come sit back, relax, get a cup of java, and experience the most wonderful, and entertaining salon experience of your life.
Phone: (719) 475-2266 Fax: (719) 634-8101 Email: email@example.com firstname.lastname@example.com
Ask about our Keratin Smoothing Treatments. Truly Amazing!
© 2013 Lady Godiva Hair Studio. All Rights Reserved.


text:
Links to individual gene pages for 85 genes within the genomic region: chr7_6:31662702-38693201
chr7_6: 31662702-38693201 (7030500 bp containing 85 genes)
ENSG00000106341 a.k.a. 'C7orf16' at chr7:31714593-31693354 (1)
ENSG00000223070 a.k.a. 'AC006377.3' at chr7:31800484-31800387 (1)
ENSG00000154678 a.k.a. 'PDE1C' at chr7:32305466-31757318 (-1)
ENSG00000177329 a.k.a. 'AC018641.3' at chr7:32478262-32477585 (1)
ENSG00000106355 a.k.a. 'LSM5' at chr7:32501420-32492942 (-1)
ENSG00000210411 a.k.a. 'AC018645.4' at chr7:32724582-32724496 (-1)
ENSG00000207573 a.k.a. 'hsa-mir-550-2' at chr7:32739214-32739118 (1)
ENSG00000210417 a.k.a. 'AC018645.4' at chr7:32798080-32797952 (1)
ENSG00000170852 a.k.a. 'KBTBD2' at chr7:32897897-32874311 (-1)
ENSG00000205763 a.k.a. 'RP9P' at chr7:32949307-32922953 (-1)
ENSG00000222002 a.k.a. 'AC018648.5' at chr7:32949307-32923396 (-1)
ENSG00000210427 a.k.a. 'AC083863.2' at chr7:33008190-33008097 (-1)
ENSG00000122642 a.k.a. 'FKBP9' at chr7:33013067-32963577 (1)
ENSG00000105778 a.k.a. 'AVL9' at chr7:33045041-32501663 (1)
ENSG00000210431 a.k.a. 'AC074338.1' at chr7:33052227-33051935 (-1)
ENSG00000222782 a.k.a. 'SRP_euk_arch' at chr7:33052227-33051936 (-1)
ENSG00000122643 a.k.a. 'NT5C3' at chr7:33068934-33020267 (-1)
ENSG00000164610 a.k.a. 'RP9' at chr7:33115527-33100937 (-1)
ENSG00000222741 a.k.a. '5S_rRNA' at chr7:33183995-33183877 (1)
ENSG00000122507 a.k.a. 'BBS9' at chr7:33612205-33135677 (1)
ENSG00000173862 a.k.a. 'AC008080.1' at chr7:33734590-33732118 (1)
ENSG00000203495 a.k.a. 'AC008080.1' at chr7:33814231-33813918 (1)
ENSG00000164619 a.k.a. 'BMPER' at chr7:34162009-33911048 (1)
ENSG00000202431 a.k.a. 'U6' at chr7:34303735-34303633 (-1)
ENSG00000214841 a.k.a. 'AC005493.1' at chr7:34666297-34652234 (-1)
ENSG00000210454 a.k.a. 'AC005174.1' at chr7:34759851-34759561 (1)
ENSG00000222661 a.k.a. 'SRP_euk_arch' at chr7:34759858-34759561 (1)
ENSG00000197085 a.k.a. 'AC005582.1' at chr7:34767328-34356559 (-1)
ENSG00000187258 a.k.a. 'NPSR1' at chr7:34884469-34664422 (1)
ENSG00000210460 a.k.a. 'AC004788.1' at chr7:34898683-34898555 (1)
ENSG00000221669 a.k.a. 'hsa-mir-548n' at chr7:34946971-34946897 (-1)
ENSG00000173852 a.k.a. 'DPY19L1' at chr7:35044178-34927606 (-1)
ENSG00000210469 a.k.a. 'AC005826.1' at chr7:35155669-35155590 (-1)
ENSG00000189212 a.k.a. 'AC005400.1' at chr7:35192299-35087426 (-1)
ENSG00000164532 a.k.a. 'TBX20' at chr7:35260283-35208567 (-1)
ENSG00000122557 a.k.a. 'HERPUD2' at chr7:35701270-35638794 (-1)
ENSG00000185671 a.k.a. 'AC007551.1' at chr7:35774775-35774482 (-1)
ENSG00000221156 a.k.a. 'AC007551.1' at chr7:35849108-35849024 (1)
ENSG00000214811 a.k.a. 'AC007551.1' at chr7:35853561-35853181 (-1)
ENSG00000122545 a.k.a. 'SEPT7' at chr7:35911440-35807345 (1)
ENSG00000200446 a.k.a. 'U6' at chr7:35936399-35936293 (-1)
ENSG00000205745 a.k.a. 'AC083864.2' at chr7:36091865-36085219 (1)
ENSG00000122547 a.k.a. 'EEPD1' at chr7:36307677-36159361 (1)
ENSG00000201432 a.k.a. 'Y_RNA' at chr7:36343912-36343801 (-1)
ENSG00000164542 a.k.a. 'KIAA0895' at chr7:36396259-36330284 (-1)
ENSG00000011426 a.k.a. 'ANLN' at chr7:36459923-36395957 (1)
ENSG00000222789 a.k.a. '5S_rRNA' at chr7:36599900-36599803 (-1)
ENSG00000210490 a.k.a. 'AC087069.3' at chr7:36599900-36599815 (-1)
ENSG00000221561 a.k.a. 'AC087069.3' at chr7:36648374-36648277 (-1)
ENSG00000136250 a.k.a. 'AOAH' at chr7:36730595-36519135 (-1)
ENSG00000214807 a.k.a. 'AC007349.1' at chr7:36825823-36825089 (1)
ENSG00000221325 a.k.a. 'hsa-mir-1200' at chr7:36925562-36925487 (-1)
ENSG00000221157 a.k.a. 'AC009196.14' at chr7:37111740-37111653 (-1)
ENSG00000210496 a.k.a. 'AC007444.1' at chr7:37175908-37175810 (-1)
ENSG00000222869 a.k.a. 'U6' at chr7:37357372-37357272 (1)
ENSG00000213744 a.k.a. 'AC078843.2' at chr7:37382151-37381635 (1)
ENSG00000200113 a.k.a. 'SNORA51' at chr7:37425895-37425756 (1)
ENSG00000201566 a.k.a. 'Y_RNA' at chr7:37441344-37441243 (1)
ENSG00000155849 a.k.a. 'ELMO1' at chr7:37455036-36860486 (-1)
ENSG00000178503 a.k.a. 'AC009530.5' at chr7:37592457-37591628 (-1)
ENSG00000187037 a.k.a. 'GPR141' at chr7:37747438-37746521 (1)
ENSG00000086288 a.k.a. 'TXNDC3' at chr7:37906525-37854724 (1)
ENSG00000106483 a.k.a. 'SFRP4' at chr7:37922903-37912247 (-1)
ENSG00000086289 a.k.a. 'EPDR1' at chr7:37958065-37926688 (1)
ENSG00000010270 a.k.a. 'STARD3NL' at chr7:38236794-38184458 (1)
ENSG00000211686 a.k.a. 'TRG@' at chr7:38255698-38246150 (-1)
ENSG00000211687 a.k.a. 'AC006033.2' at chr7:38259555-38259506 (-1)
ENSG00000211688 a.k.a. 'AC006033.2' at chr7:38262522-38262463 (-1)
ENSG00000211689 a.k.a. 'TRGV9' at chr7:38271804-38266214 (-1)
ENSG00000211690 a.k.a. 'AC006033.2' at chr7:38275666-38275617 (-1)
ENSG00000211691 a.k.a. 'AC006033.2' at chr7:38279775-38279713 (-1)
ENSG00000211692 a.k.a. 'AC006033.2' at chr7:38282444-38282385 (-1)
ENSG00000211693 a.k.a. 'TRGV11' at chr7:38298204-38297742 (-1)
ENSG00000211694 a.k.a. 'AC006033.2' at chr7:38306406-38305937 (-1)
ENSG00000211695 a.k.a. 'AC006033.2' at chr7:38323618-38323143 (-1)
ENSG00000211696 a.k.a. 'AC006033.2' at chr7:38336947-38336469 (-1)
ENSG00000211697 a.k.a. 'TRGV5' at chr7:38355950-38355481 (-1)
ENSG00000211698 a.k.a. 'AC007245.3' at chr7:38360309-38359841 (-1)
ENSG00000211699 a.k.a. 'TRGV3' at chr7:38365105-38364638 (-1)
ENSG00000211700 a.k.a. 'AC007245.3' at chr7:38369454-38368990 (-1)
ENSG00000211701 a.k.a. 'AC007245.3' at chr7:38374181-38373712 (-1)
ENSG00000209031 a.k.a. 'AC012490.3' at chr7:38537464-38537167 (-1)
ENSG00000223296 a.k.a. 'SRP_euk_arch' at chr7:38537464-38537168 (-1)
ENSG00000078053 a.k.a. 'AMPH' at chr7:38637545-38389832 (-1)
ENSG00000164556 a.k.a. 'FAM183B' at chr7:38693162-38691469 (-1)


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Approximately one-third of all fatal crashes each year in the U.S. involve an alcohol-impaired driver. Prior research has shown that alcohol alters perceptions of risky behaviors such as drinking and driving. However, studies testing these perceptions typically measure them while participants are sober. A new study measuring the perceived dangerousness of driving after drinking assessed while individuals were intoxicated, and comparing these perceptions to those assessed while sober, found that sober knowledge does not necessarily translate into responsible judgment while intoxicated.
Results will be published in the February 2014 issue of Alcoholism: Clinical & Experimental Research and are currently available at Early View.
"Alcohol can alter how we perceive a number of things," said Denis M. McCarthy, associate professor at the University of Missouri as well as corresponding author for the study. "For example, we know that alcohol can impair someone's judgment, decrease their self-control, and alter what elements of their situation they attend to. Based on this, we were interested in examining whether alcohol can alter how the risks associated with impaired driving are appraised."
"It is stating the obvious, but people who decide to drive while under the influence of alcohol make those decisions while under the influence of alcohol," said Mark B. Johnson, a senior research scientist at the Pacific Institute for Research and Evaluation. "Research has generally focused on the judgments of sober individuals, and prevention messages are targeted to potential drinking drivers while they are sober. However, the present research shows us that the sort of decisions people think they would make while sober may be different than the decisions they would make after drinking. If we want to understand how to change people's drinking and driving decisions in the real world, we need to study decision making under the influence of alcohol."
McCarthy fully agreed. "It is important to examine how people make decisions in the context in which the decisions are made. For example, if we want to understand how people make decisions under stress, we know it is important to study their decision-making process while stressed. Similarly, the decision to get behind the wheel while intoxicated is ultimately made while intoxicated."
McCarthy and his colleagues recruited 82 young adults (43 men, 39 women) from a large, Midwestern university and its surrounding community via flyers and university informational emails to attend two counterbalanced laboratory sessions. During one session, participants consumed a moderate dose of alcohol (.72 g/kg for men, .65 g/kg for women) and reported the perceived danger of driving and their willingness to drive at multiple points across the breath alcohol concentration (BrAC) curve. On a separate occasion, participants remained sober and appraised the dangerousness of driving at a hypothetical, illegal BrAC.
"We found that, when intoxicated, a person's appraisal of the risk of driving in that state can play an important role in their choice of whether to drive over and above their sober thoughts about drinking and driving," said McCarthy. "We think this is important because it seems that people have gotten the message drinking and driving is dangerous, and most people, when they are sober, honestly think it is too dangerous to do. However, those same individuals may not apply this judgment when it counts the most - when they are currently intoxicated and need to decide whether it is safe for them to drive in that moment."
"This difference was pronounced for both men and women only on the descending leg of the alcohol curve," added Johnson. "Drinkers coming down from their peak BAC feel that it is safer to drive than did sober persons thinking about drinking and driving. "Second, not only were the perceptions of risk different between sober and drinking participants, but the perceptions were significantly related to willingness to drive. People, while intoxicated, who rated driving risk as relatively low were more likely to indicate a willingness to drive; further, there was some evidence that perceptions of low risk were associated with actually having driven after drinking in the recent past."
"One suggestion from our data is that it is not enough for people to be aware of drinking and driving risks, or even to know intellectually how much alcohol it takes to make driving unsafe," said McCarthy. "People need to be able to apply this knowledge to a specific situation. What's more, they need the skills to apply it while they are currently impaired by alcohol."
"Evidence suggests that public information/awareness campaigns have only very modest effects on drinking and driving, and of the campaigns that actually are effective, many include additional elements like increased law enforcement," added Johnson. "It isn't clear that providing the same risk-awareness messages over and over is going be effective. However, several studies that I have been involved with suggest that providing a simple cue to drinkers not to drink and drive right before they go out drinking seems to reduce alcohol consumption by drivers. This dovetails with the current research in that the timing of the message is important. I don't think that risk messages need to be very complicated or novel because most people already know the information - but the timing may matter a great deal."
Johnson added that a question prompted by this research concerns what would happen if people receive a risk message while intoxicated, shortly before deciding whether to drive home. "The data show that intoxicated persons perceive the drinking and driving risk to be lower, so maybe providing them with risk information at this point may be ideal," he suggested. "However,]it is possible that being intoxicated would interfere with the message having any persuasive effect at all. Conversely, giving people a brief drinking and driving message right before they start drinking might be a good approach. All that said, given that alcohol affects decision-making, getting people to make their drinking and driving decisions in advance, before they become influenced by alcohol, makes sense. One should determine in advance how to get home safely. Assigning a designated driver or taking a taxi to the drinking establishment helps alleviate the harm that might come from impaired decision-making later in the evening."
Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
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BREAKING NEWS: House Approves Budget Agreement, 332-94
Journalist Mary Garber
Washington, DC Saturday, June 25, 2011
Mary Garber went to work as a society editor at North Carolina's Winston-Salem Journal in 1940, then transferred to sports in 1946 and never looked back. Her life-long career as a sports reporter is chronicled in this oral history for the Washington Press Club Foundation's "Women in Journalism" project. She recalls her love of sports reporting, the discrimination she faced as a woman, and her determination to cover black high school athletes in the segregated South. This program is the first half of a two-part interview.
Updated: Monday, June 27, 2011 at 12:29pm (ET)
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I had mild sleep apnea before my gastric bypass weight loss surgery. Sleep apnea is a dangerous sleep disorder characterized by interrupted breathing while asleep. Although I have no knowledge of how many times I may have stopped breathing during the night, persons affected by sleep apnea can stop breathing hundreds of time during the night. This action can compromise the supply of oxygen to the brain.
There are two types of sleep apnea, obstructive sleep apnea and central sleep apnea.
Obstructive sleep apnea occurs when the airway becomes blocked, usually by a collapse of soft tissue at the back of the throat. Central sleep apnea occurs when the brain does not send signals to the muscles to breath.
Sleep apnea can cause depression, high blood pressure, and stroke and can affect any person of any age. Causes include having a family history of sleep apnea, nasal obstructions, being over forty years old, and obesity. Of course, I was obese.
Individuals who have sleep apnea complain of fatigue, headaches in the morning, and moodiness. They fall asleep easily and could doze off under any conditions from watching television to driving a car.
The disorder is often first noticed by spouses or partners who are disturbed by the loud snoring that accompanies the disorder. Just ask my husband about that... oy veh!
Sleep Apnea and Obesity
Obstructive sleep apnea is most common among those who are obese. The airway becomes obstructed by large tonsils or an enlarged tongue and press against the airway.
To complicate the problem, obesity not only promotes sleep apnea but sleep apnea causes people to eat more due to sleep deprivation. Sleep apnea seems to disturb hormones that control eating habits.
Bariatric Surgery and Sleep Apnea
Many people who have bariatric surgery show improvement in sleep apnea although it is difficult to determine the extent of the improvement.
The severity of the sleep apnea plays an important role in the resolution of the disorder after gastric bypass surgery. A study published in the August, 2008 issue of Journal of Clinical Sleep Medicine determined that while weight loss surgery can improve sleep apnea, it does not necessarily resolve it.
While the required pressures for continuous positive airway pressure (a treatment that uses mild air pressure to keep airways open) were decreased on average, only four percent of patients reported resolution of sleep apnea.
I have been fortunate. My sleep apnea -- and many other obesity-related illnesses were resolved after my gastric bypass surgery. Perhaps the cards were stacked in my favor since I had only mild sleep apnea. I never recieved continuous positive airway pressure.
Although sleep apnea is one of the criteria used to determine the medical necessity for weight loss surgery, only a small portion of bariatric patients report resolution of sleep apnea even after impressive weight loss.
Many doctors and surgeons are reluctant to qualify weight loss surgery as a cure for sleep apnea because of concerns about inappropriately discontinuing continuous positive airway pressure therapy.