text:
Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan.
CD44-mediated cell adhesion to hyaluronate is controlled by mechanisms which are poorly understood. In the present work we examine the role of N-linked glycosylation and Ser-Gly motifs in regulating CD44-hyaluronate interaction. Our results show that treatment of a panel of human cell lines which constitutively express CD44 with the inhibitor of N-linked glycosylation tunicamycin results in the loss of attachment of these cells to hyaluronate-coated substrate. In contrast, treatment of the same cells with deoxymannojirimycin, which inhibits the conversion of high mannose oligosaccharides to complex N-linked carbohydrates, results in either no change or an increase in CD44-mediated adhesion to hyaluronate, suggesting that complex N-linked oligosaccharides may not be required for and may even inhibit CD44-HA interaction. Using human melanoma cells stably transfected with CD44 N-linked glycosylation site-specific mutants, we show that integrity of five potential N-linked glycosylation sites within the hyaluronate recognition domain of CD44 is critical for hyaluronate binding. Mutation of any one of these potential N-linked glycosylation sites abrogates CD44-mediated melanoma cell attachment to hyaluronate-coated surfaces, suggesting that all five sites are necessary to maintain the HA-recognition domain in the appropriate conformation. We also demonstrate that mutation of serine residues which constitute the four Ser-Gly motifs in the membrane proximal domain, and provide potential sites for glycosaminoglycan side chain attachment, impairs hyaluronate binding. Taken together, these observations indicate that changes in glycosylation of CD44 can have profound effects on its interaction with hyaluronic acid and suggest that glycosylation may provide an important regulatory mechanism of CD44 function.[1]References
- Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. Bartolazzi, A., Nocks, A., Aruffo, A., Spring, F., Stamenkovic, I. J. Cell Biol. (1996) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Use


text:
This was Not like the good old days, but it may have been romantic memories. The burgers were not flavorful and the fries were not hot. Not a welcoming atmosphere
This was Not like the good old days, but it may have been romantic memories. The burgers were not flavorful and the fries were not hot. Not a welcoming atmosphere
I have never had krystal. We do not have them in Louisville, we have white castle. I never heard anybody say anything positive about them. My wife and I just left this one and it was great!. Burgers were good, service was good and atmosphere was clean. I wish we had this in louisville.
Like one other review said- the service is TERRIBLE. absolutely terrible. Waited forever in line and when we finally got to order out food the person very impolitely said "sir just pull forward I can't understand a word you're saying" and when I got up the window to order they were VERY rude. And our food was cold. NEVER will... More
My son loves Krystal burger and we have given them pleanty of chances to improve and win us back over. They are rude, the food is always cold and they always mess up our order. We talked to the GM Rusty and he did nothing, he was rude and made us to where we will never return. The restaurant was... More
Hardly a trip goes by that I don't stop for Krystal burgers. Food is consistently good and always fresh. Great deals on food.
Great food for fast food burgers. Always get them when I visit the South, we don't have Krystal or White Castle in the NorthWest. That being said....service is horrible! One example - went the other day for breakfast. They stop serving at 10:30am. Was in the drive through a couple of minutes before that with one car in front of... More
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subset: commoncrawl


text:
- December 24, 2009
- 11:46 a.m.
- Suggest removal
- Reply to this post
one_eye_open writes:
Well, I guess the "GRASS ISN'T GREENER" on the other side. I remember a recruitment poster from Simi PD a few years back using the saying, "The grass really is greener in Simi Valley." It is no secret that Simi PD has long been the highest paid agency in the county. Not to mention some of the best beni's. I know no one like taking a pay cut, but for them, a cut is only making them about equal with the rest of the departments in VTA Co.
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text:
Customer Reviews
2 Review(s)
Rating:Posted By: STEVE DAMICO from HAMPSTEAD , NC
May 19, 2011Smooth!
Just put the boxwood Flesch with hUmp on my Violin and so far very comfortable. Puts the violin up on my shoulder and now I have to figure out a different approach as far as a shoulder rest oes. Oh brother. LoL ?;^) ... (See Full Review)
4 out of 4 people found this review helpful
Was this review helpful? Yes No -
Rating:Posted By: SAM MIHAILOFFCT from CT
March 04, 2009quality
The quality of this chinrest is far superior to those offered elsewhere, but then again I find Shars consistency of product to be always excellent. I have been a very satisfied customer since 1966 ... (See Full Review)
8 out of 13 people found this review helpful
Was this review helpful? Yes No
You can still order this item today. Shar ships in stock items immediately and there's no extra shipping charge for your backordered items. For more information please click here: Backorder Policy


text:
Mailinglist Archive: opensuse-wiki (21 mails)
< Previous | Next > |
[opensuse-wiki] Re: [opensuse-web] Wiki automatic capabilities for keeping localization up to date
- From: Stathis Agrapidis <stathisagrapidis@xxxxxxxxx>
- Date: Sat, 18 Feb 2012 01:51:04 +0200
- Message-id: <email@example.com>
On Thu, Feb 16, 2012 at 12:23 PM, Thomas Schmidt <tom@xxxxxxxxxxxx> wrote:
Ok, got it, if I find something I will let you know.
Nice, that is exactly what I was looking for!
Thanks for your time and answers.
To unsubscribe, e-mail: opensuse-wiki+unsubscribe@xxxxxxxxxxxx
To contact the owner, e-mail: opensuse-wiki+owner@xxxxxxxxxxxx
On 14.02.2012 21:43, Stathis Agrapidis wrote:
Hello everybody,
Hope this is the appropriate list to ask.
In Greece we are trying to figure out the best way to organize the
lokalization of the wiki. We are currently translating pages and we
have already translated a lot but there are two things we need to
figure out:
1) Is there a way to interconnect the translated page to the original
one, so that the wiki knows when the original page changes and
therefore automatically print a message on the translated one that it
might be out of date?
Tip: I have already found out how to list the greek one at the bottom
left box, which shows the translated pages for it. Question is: Is
that enough?
As you already found out, the pages are connected in the sidebar by adding
[[<language>:<pagename>]]. I think there is no build-in method in mediawiki
for the feature you are missing. Maybe there is an extension that can help
if you find one, I can help getting it added to our wiki.
Ok, got it, if I find something I will let you know.
2) The translator knows if the original page changes when it chooses
to watch the original page from the "watch" button. Is there a central
place where all the outdated pages are indicated? I am asking this
because we want to formulate a quality assurance procedure for the
translated wiki.
You can get a list of changes to your watched pages here:
and you can get notified by mail on changes if you activate it here:
Nice, that is exactly what I was looking for!
That's all for now :)
Thanks for helping with the greek wiki :-)
Thanks for your time and answers.
Thomas Schmidt (tom [at] opensuse.org)
openSUSE Boosters Team
"Don't Panic", Douglas Adams (11.03.1952 - 11.05.2001)
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To contact the owner, e-mail: opensuse-web+owner@xxxxxxxxxxxx
To unsubscribe, e-mail: opensuse-wiki+unsubscribe@xxxxxxxxxxxx
To contact the owner, e-mail: opensuse-wiki+owner@xxxxxxxxxxxx
< Previous | Next > |


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Related Sections: | West Saint Paul | Dakota County |
Southview Country Club
239 E Mendota RdWest Saint Paul, MN 55118
Phone: (651)451-6856Fax: (651)451-0409
This course was built on hilly terrain and features elevated greens and tree-lined fairways. There are water hazards coming into play on five holes. The Tape Mart Pro/Am is held here every year. The signature hole is #11, a 155-yard, par 3, requiring a tee shot from off an elevated tee to an island green.
Holes: 18 | Greens: Bent Grass | Fairways: Poa Annua Grass |
Greens Fees: | $50-$79 |
Course Type: | private |
Dress Code: | No denim, collared shirt and bermuda shorts required |
Season: | Apr 1 to Nov 1 (closed on Mondays) |
Guest Policy: | Closed |
* Update this Course: Update/modify the details for this golf course's listing.
Course reviews for Southview Country Club
Average Golfer Review (4.0 Stars):
Number of Reviews: 1
Review this course and share your experience with other golfers.
0 of 0 people found the following review helpful: |
Updates, May 07, 2004 |
reviewer: Anonymous
from Anonymous |
The person/persons who wrote the first imformation about the golf course didnt do a lot of background checks. The 11th hole is now a medium length par 4 and No. 15 is the signature hole (revamped in 2003). Also, its the TAPEMARK not Tape Mart. |


text: Beyonce Inspired Eye Tutorial Video Watch to learn how to do a Beyonce inspired eye look. Very easy to do mixing blue with pink in the crease for a sultry, nightime look. June 14, 2011 Email 0 Share Embed This Video This Is A Developing Story Related Video TRENDING TOPICS Couture Fashion Week Beauty Tips Hairstyles Horoscopes Celebrity Style


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Published: 9 August, 2012
by CATHERINE ETOE
THEY may have crashed out of the Olympics without a medal but Arsenal Ladies star Kelly Smith (pictured) hopes Team GB's
performances will have inspired more women and girls to take up football.
Smith, 33, picked up a knock in the historic win over Brazil at Wembley and had to watch from the sidelines as GB fell at the quarter-finals on Friday.
Afterwards the Arsenal player could hardly hide her disappointment at the 2-0 defeat but said she was now turning her attention to the Gunners' Women's Super League campaign.
"We fell short," she said. "Ultimately, we wanted to medal and we're all hurting. But once we come down off this we'll reflect and think what a great ride we had.
"I hope we inspired a lot of people along the way. It's back to the WSL now, we've got to play Everton away and regroup."
Arsenal Ladies travel to Everton on August 19, kick-off is at 2pm.


text:
- October 7, 2012
- 2:24 p.m.
- Suggest removal
- Reply to this post
MCartossa writes:
This is not investigative reporting, the courts are following the law and there is little that can be done to shorten the process. Buying the paper this morning was a waste of $1.50. I purchase the LOCAL paper for LOCAL news which was in very short supply in today's paper. Hopefully tomorrow's paper is better than today's. I think cancelling Sunday's paper will be on the top of my too do list if next week's paper is anything like today's.
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text:
Recommended Websites
Web Links Home > InfoGreen > Waste Management
Eco Yellow Pages -
Tired of receiving stacks of phone books every year that will never be used? Learn how to stop the delivery of phone books.
Garbage: How Can My Community Reduce Waste? -
This site provides an introduction to global waste management and offers some possible solutions. Topics include solid waste, sewage, hazardous waste and sustainable living. The site offers annotated links to sites for further reading.
How to Get Rid of Stuff You Don't Want or Need -
This site, from King County's Natural Resources & Parks Water Treatment Division, recommends methods for disposing of residential and household waste. Find information about items that should go down toilets, sinks, drains, or in the garbage.
Local Hazardous Waste Management Program in King County -
The Local Hazardous Waste Management Program focuses on helping local residents and business owners and operators use fewer toxic materials. The site contains information on how to properly use and store hazardous materials and also how to dispose of hazardous products. The site also features a free service designed to help businesses find markets for their byproducts, surplus materials and waste.
School Recycling & Waste Reduction Assistance – King County Solid Waste Division -
This program helps schools start or improve recycling programs, increase waste reduction activities and increase the use of recycled-content and other environmentally preferable products.
Seattle Solid Waste Recycling, Waste Reduction, and Facilities Opportunities Report -
This two-volume report was prepared for the Seattle City Council and Seattle Public Utilities. It concludes a five-month study that looks at recycling in Seattle and the need for renovated or new solid waste recycling and disposal stations.
Zero Waste America -
Read about Zero Waste America and how they advocate for the recycling of all materials back into nature or the marketplace in a manner that protects human health and the environment.


text:
(7963 quotes found)
"If you cant beat them buy them"
Kenneth waters Jr
"Why are we so deeply indebted to china,When we already gave them all our jobs"
"The road to success is paved with depression."
vineck kumar Posaria
"I don't want to just be another black man; I want to be the greatest black man."
Rayshon Thornwell
"what keeps me going is the fact that there is someone out there who wants to be in my "shoes"..yes,mine are worn&over worked but all that other person prays for are "shoes" & so i make the most of the ones i have on."
Phillip Buyondo
"A movie that is enjoyed and appreciated a lot by many viewers may be a big hit on the box office, but the one that is understood by masses and has made a good difference by changing the mindset of society is a successful movie irrespective of its day or fund collection on the box office."
Anuj Somany
"I told Randy I wish him lots of success except for one game."
Phillip Fulmer
"On Becoming a Young Dad: How unfortunate it is to be dismissed because of a number, but how fortunate I am to have the opportunity to prove my worth."
Matt Gannon
"When we are forced to adapt to something unknown to us, we learn things about ourselves. This knowledge helps us to flourish. If you fight it, this process is damaged. Accept change for what it is: a chance to learn, to grow, and to succeed."
"No matter your creed, or the people you descend from, no matter how many other people there are, you are in control of your world. Make it bend to your will. Master your skills, form alliances, explore the boundless world of Earth. The possibilities are infinite."


text:
- December 28, 2011
- 11:56 a.m.
- Suggest removal
- Reply to this post
toddbasketball writes:
Please try and bring the Dodgers back to Vero!!
Callan and O'Malley are the guys that can make it happen.
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text:
We have stayed at Matakana Castle twice now and both times we have thoroughly enjoyed ourselves. Nat and John are fantastic hosts who provide just the right mix of friendly hospitality while still allowing guests private chill out time in the spacious guest lounge overlooking the ocean. Rooms are impeccable and the breakfast delicious. Overall we recommend to anyone.
- Official Description (provided by the hotel):
- Matakana Castle is luxury bed and breakfast accommodation set in 3.5 acres of rural splendor with magnificent sea views over Kawau Bay from every room. Three luxurious rooms all with en-suite bathrooms. The Tower Suite is the perfect place to celebrate a special occasion whether it be your honeymoon night or you just feel like spoiling yourself. Enjoy our 2 course gourmet breakfast which is included in the price. Enjoy a glass of wine in front of the roaring log fire whilst enjoying the breathtaking views. Complimentary wine and hors oeuvres are included in the price as well as sweet treats in each room and fresh flowers. ... more less


text:
Home |
LARGE ANTIQUE SILK & GILT EMBROIDERY browse these categories for related items... All Items: Antiques: Regional Art: Asian: Chinese: Textiles: Pre 1900: item # 850142 Please refer to our stock # G0043 when inquiring.
Asian Art Online 5942 Edinger Avenue, Suite 113 , PMB 109 Huntington Beach, CA 92649, USA 714-846-8913 Guest Book Sold |
Early 19th Century large and framed Chinese silk and gilt thread embroidery .Overall design of dragons amongst flames and clouds; top panel on dark brown ground, bottom with colorful ocean wave representing the emperors power sending to the people. Excellent condition. L: 40 W: 19. |


text:
Question: From Essex, England:
Do you know of any side effects to hormones or ovaries when using glargine (Lantus) insulin once daily and four fast acting injections? Can this cause a delay in puberty?
No, but I would be interested to know why this question arose.
Original posting 9 Jan 2005
Posted to Other and Insulin Analogs
Last Updated: Tuesday April 06, 2010 15:09:59
This Internet site provides information of a general nature and is designed for educational purposes only. If you have any concerns about your own health or the health of your child, you should always consult with a physician or other health care professional.
This site is published by Children With Diabetes, Inc, which is responsible for its contents.
By using this site, you agree to our Terms of Use, Legal Notice, and Privacy Policy.
© Children with Diabetes, Inc. 1995-2014. Comments and Feedback.


text:
Reuters | 12/27/2012 3:23 PM
Printer-friendly version [2] | Send to friend [3] | Share your views [4]
Hugh Jackman in a scene from "Les Miserables" |
LOS ANGELES, California - A strong Christmas-day box office performance by musical "Les Miserables" and western "Django Unchained" put Hollywood on pace to set an all-time box office record with $10.8 billion in annual revenue, box-office tracker Hollywood.com said on Wednesday.
Universal Pictures' star-studded "Les Miserables" took in a weekday Christmas record of $18.2 million in the United States and Canada when it opened on Tuesday, according to studio estimates of weekday ticket sales.
Quentin Tarantino's spaghetti western "Django Unchained," starring Jamie Foxx and Leonardo DiCaprio, hauled nearly $15 million for The Weinstein Co.
Studios "are definitely on the road to a record year with $10.8 billion expected (up 6% over last year and beating the previous record of $10.6 billion in 2009)," Hollywood.com analyst Paul Dergarabedian told Reuters in an email, adding that the number of tickets sold should climb 6% from 2011 to 1.36 billion.
Dergarabedian credits a successful marketing year for studios as a chief reason for the projected box-office record, as well as spring and summer smashes "The Hunger Games" and "The Avengers" helping boost revenue.
"It was not just the fact that most of the movies delivered, it was the timing of their release dates and the marketing was obviously effective as well with social media continuing to provide an outlet for the moviegoing peer group to talk about their favorite flicks," Dergarabedian said.
"The Hobbit: An Unexpected Journey," based on the J.R.R. Tolkein classic fantasy novel, brought in $11.4 million on Christmas Day after ruling the box office with nearly $37 million in sales over the weekend.
The Billy Crystal family film "Parental Guidance" debuted in fourth place with about $6.4 million in Christmas sales while Tom Cruise's "Jack Reacher," which featured author Lee Child's character in an investigation into a sniper shooting, was fifth with some $5.3 million.
"The Hobbit" was distributed by Time Warner Inc's Warner Bros. Studio. News Corp's 20th Century Fox released "Parental Guidance" and Paramount Pictures, a unit of Viacom, released "Jack Reacher." Universal Pictures is owned by Comcast Corp.
[1] http://www.abs-cbnnews.com/
[2] http://www.abs-cbnnews.com/print/print/264400
[3] http://www.abs-cbnnews.com/printmail/print/264400
[4] http://www.abs-cbnnews.com/entertainment/12/27/12/hollywood-set-record-year-christmas-box-office#comment-form
[5] http://del.icio.us/post?url=http://www.abs-cbnnews.com/entertainment/12/27/12/hollywood-set-record-year-christmas-box-office&title=Hollywood set for record year with Christmas box office
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text:
People are combing over video of Beyoncé's Super Bowl Halftime performance, trying to find a wardrobe malfunction in there somewhere. Some people claim Beyoncé had a nip-slip...while others think she may have showed off a little too much of the entrance to her birth canal. The fact is, there was no nudity in either case. Meanwhile, Beyoncé is launching a tour with the identity-crushing title of "The Mrs. Carter Show".
see the gallery of her performance ---> HERE
First off, Beyoncé's top WAS kind of revealing and loose. But despite a slow-motion clip of her breasts bouncing freely inside of it, there's ZERO EVIDENCE that any nipple popped out.
Meanwhile, MediaTakeOut.com says Beyoncé showed too much CROTCH. But even their own close-up photos don't reveal anything.
(--You can see them here.)


text:
Carl Icahn files official shareholder proposal with Apple [u]
12/04, 3:52pm
Admits 'Steve Jobs probably wouldn't have talked to me'
(Updated with Twitter comment on buyback cap) Investor Carl Icahn filed a shareholder proposal for an Apple stock buyback on November 26th, a new TIME interview reveals. Icahn has been trying to pressure Apple into expanding its current buyback from $60 billion to $150 billion, and having it take effect immediately, rather than run through 2015. In response to the interview, Apple has issued a statement. "As part of our regular review process, we are once again actively seeking our shareholders' input on our program, and as we said in October, the management team and our board are engaged in an ongoing discussion about it which is thoughtful and deliberate," a spokesperson says.


text:
Go Back! Mother3Cactus Wolf Will EET U - by PoeTrader
Other Submissions by PoeTrader
Author | Title | Description | Date | Rank |
PoeTrader | STOP! Hammertime! |
A watercolor pencil painting of the Frosty Wolf (though I like to call him the "Chilly Dog"). His action is based on his description: "It's frozen over and boasts the ability to hammer nails with its own tail." This one took me around 45 minutes to complete.
3/29/06 | 0.00 |


text:
A legacy of care
Check out how we help our community
Check out the yearly report
Check out our achievements
Hear directly from our patients
Help our community
Find where you need to go
Get in the know
Plan a visit
Send a card or a gift to a patient
Helping ease kids' nerves & worries
Private room care
Caring for newborns to teens
Helping children manage diabetes
See All Classes & Events »
Free class for first time parents
Helping siblings learn the adjustment
Teaching car seat safety
Resources for protecting our kids
Teaching kids healthy habits
Teaching kids about fire
Informed kids are safer kids
Education leading to prevention
Beyond the hospital walls
Health information for parents
Health information for kids
Health information for teens
Resources for providers
An assortment of educational resources
Info to keep kids safe & healthy
(En español: Dientes caninos)
Say: kay-nine teeth
Woof, woof, what's that tooth? Your canine teeth are the pointy ones next to your front teeth. You have two on top and two on the bottom. Because they're sharp, they help tear food. Grrrr!


text:
View the most popular tags overall?
Caveat emptor means "buyer beware." Fake medicines are now a multibillion-dollar industry affecting people in virtually every country in the world, and the problem is getting worse. It has been estimated that up to 15 percent of drugs sold worldwide are counterfeit, and in parts of Africa and Asia it can surpass 50 percent. We are also vulnerable in the United States even though we have a better-regulated pharmaceutical system.
Dr. Leon Morgenstern, Cedars-Sinai's inaugural director of surgery and founder of its Center for Healthcare Ethics, died on Dec. 23. He was 93.
A committee of the European Parliament has endorsed measures to simplify the sale of Israeli pharmaceuticals within the European Union.
Paying for the upkeep of the Gaza Strip while its political rival actively blocks revenues flowing back is taking its toll on the deficit-racked Palestinian Authority.
Martine Ehrenclou, 51, first noticed her lower abdomen pain in January 2010. She experienced severe discomfort if she sat at her desk for even 15 minutes, when she drove her car or any time that she pitched forward. Ehrenclou, who lives in Brentwood, describes the pain as "brutal."
The Nobel Prize for medicine reportedly was awarded to two Jewish scientists, Ralph Steinman and Bruce Beutler.
On television Lisa Edelstein, a star of the hit Fox show "House," and her fellow actors work medical miracles every episode. But at an Israeli hospital she stumbled trying her hand at simulated arthroscopic surgery. "I'm so glad this is not a living person," she said Wednesday, shifting the controls over a robotic dummy, eyes fixed on a computer screen that revealed her would-be patient's internal organs. "I think I just mangled its liver."
The United Nations announced last year that the procedure could reduce the rate of HIV transmission by up to 60 percent. It was in Israel, with its experience performing adult male circumcision on a wide scale, that the international medical community found an unlikely partner in the global fight against AIDS.
During a procedure, surgeons can use a touch-screen panel or voice commands to display and control images, adjust room lighting, or phone a colleague. They can access patient histories, X-rays and lab results, and use their fingers on the console to draw -- just like a football commentator -- on images displayed on a screen.
A visit with Dr. Eugene Gettelman, who celebrates his 100th birthday on June 17, shows how much medicine has gained and lost in the last half century
You've heard of the nuclear family. But how about the deoxyribonucleic family? Thirty-seven years after Arthur Kornberg won the Nobel Prize in medicine, his eldest son, Roger, took home this year's prize in chemistry.
The Power Plate features a vibrating platform that oscillates 30 to 50 times per second. Each time, it stimulates the nervous system and creates a reflex in the body that causes the muscles to contract. The Power Plate Web site lists dozens of college and professional sports teams as using vibration training in their regimens.
Freud famously called dreams "the royal road to knowledge of the unconscious." And his own dreams and their analysis revealed to him a whirl of conflicts around his Jewish identity.
Long time L.A. drycleaner Barry Gershenson was named one of four national spokespersons for the FabriCare Foundation. Gershenson, a third-generation dry cleaning veteran has more than 40 years experience as owner of Sterling Fine Cleaning in Los Angeles. As a spokesperson for the FabriCare Foundation, Gershenson's role will be to educate consumers on the definition of a "professional" drycleaner, as well as the overall benefits of dry cleaning.
In fact, few people would have recognized Franklin's contribution had it not been for Watson.
Cedars-Sinai Medical Center spans over 24 acres and encompasses 1.5 million square feet.
Irwin M. Weinstein, one of the founders of the National Israel Cancer Research Fund (ICRF) and its Los Angeles chapter, died July 21 of a stroke and kidney failure. He was 76.
The ancient rabbis practiced a relatively simple form of medicine: cabbage for sustenance, beets for healing.
For the child whose parent has been diagnosed with cancer, each day becomes fraught with uncertainty -- will Mom or Dad be there today when I get home from school, or back in the hospital? Will Dad be too sick to come to my softball game? Why does Mom have to take that medicine that makes her feel so bad? Isn't medicine supposed to make you feel better? All kinds of questions culminate in that most sinister and heartbreaking of all queries, lurking like a spider in the corner of the child's mind: Is my Mom (or Dad) going to die?
As if we don't have enough problems, it seems there's an unlimited supply of horrific hereditary diseases just waiting to ensnare Jews and their children. Tay-Sachs cripples infants before their first birthday and eventually kills them, Gaucher disease erodes healthy bones and organs, Niemann-Pick, cystic fibrosis, Crohn's, Canavan and dozens of others. And that's just among Eastern-European Ashkenazi Jews. A host of other hereditary diseases affect Sephardic, Iraqi and Persian Jews. Does somebody up there hate us?
About two-and-a-half years ago Michael Goldberg's life was on the line. A diabetic since he was a teen-ager, his kidneys began to fail him at 36. The only hope for Michael's survival was a kidney and pancreas transplant.
The rabbis-in-training were making the rounds at UCLA Medical Center. They stopped at bedsides to chat with patients, to inquire about their needs, to offer prayer and consolation. Then, unexpectedly, the sight of wires, tubes and surgical dressings took its toll. One student rabbi fainted.


text:
Company Christmas Party
It's Christmas time which means…it's time for COMPANY CHRISTMAS PARTIES! I have always enjoyed going to company Christmas parties. I've seen some amazing things at Christmas parties and I've laughed so hard I couldn't breath. All in all I would say that Christmas parties are fun, unless you have to go to 4 of them.


text:
Amazing – Chronic Urticaria Treatment Prevention
Of course most of your skin to slack. Moreover exercise in an acne skin conditions. Acne skin care needs for effective product suitable products are available in Spain Portugal Greece Belgium the Netherlands besides Luxembourg Norway Sweden and patient who suffers from this common skin cells are product and you are already done those things that should NEVER be done.
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With social networking proving to be a particularly popular activity on smartphones, Research In Motion (RIM) on Wednesday announced a stylish new smartphone for socially connected customers.
According to a report, Facebook mobile users spent more than 7 hours engaging via browsers or apps in March, as compared to six hours via the computer.
Twitter mobile users, meanwhile, spent more than 2 hours engaging on mobile devices, as compared to just 20.4 minutes on Twitter.com (with the caveat that doesn't track usage on third party desktop clients like TweetDeck).
The new BlackBerry Curve 9320 smartphone features all the core BlackBerry messaging and social centric features that keep people connected, and it offers global 3G connectivity backed by long battery life to allow users to make the most of their day.
"The new BlackBerry Curve 9320 is designed to make it incredibly easy for users to stay socially connected," said Carlo Chiarello, EVP, Smartphone Business at Research In Motion. "The new BlackBerry Curve 9320 will be especially popular with customers upgrading to a smartphone for the first time and existing Curve customers looking for a step up in speed and functionality."
The BlackBerry Curve 9320 has everything a customer needs to stay in touch with the people and things that matter most to them. It features a dedicated BBM key, bringing the power of RIM's popular mobile social network up in an instant, as well as the best keyboard in its class for quick and easy typing. It includes a built in FM radio, allowing users to tune into their favorite local stations, and listening to the FM radio does not require a data plan or use data services. Designed to allow both 3G connectivity and long battery life, customers can get up to 7 hours of talk time or up to 30 hours of FM radio listening or music playback with headphones.
Customers can easily interact with their social network in real time, using preloaded apps for Facebook and Twitter. The new Social Feeds 2.0 app is also preloaded, allowing users to post updates to multiple social networks simultaneously and capture updates from news sources (RSS), social apps and instant messaging apps all in one consolidated view. The integrated camera includes a flash and supports video recording, and pictures can be tagged with their location thanks to the smartphone's built in GPS.
The BlackBerry Curve 9320 comes with the new BlackBerry 7.1 OS, which supports features such as Mobile Hotspot and Wi-Fi calling where available. Parental Controls is a brand new, on device feature that provides parents and guardians with simple options to help protect children by restricting access to specific functions, features and applications.


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Millions of American businesses and employees remain confused about the extraordinary changes that begin to unfold in the nation's health insurance system this fall. The National Restaurant Association is advocating for changes in the Affordable Care Act, helping our members understand it, and has created services and products to ease implementation challenges.
The NRA's Health Care Reform Headquarters at Restaurant.org/Healthcare offers a one-stop shop for our members, including:
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Nearly one in 10 American workers is employed in the restaurant industry, many of them on track for long-term success.
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Home / News & Research / Research / Restaurants & the Economy / Restaurant Performance Index
The National Restaurant Association's Restaurant Performance Index (RPI) is a monthly composite index that tracks the health of and the outlook for the U.S. restaurant industry. Launched in 2002, the RPI is released on the last business day of each month.
Fueled by stronger same-store sales and traffic and a more optimistic outlook among restaurant operators, the RPI rose to a four-month high in October. The RPI stood at 100.9, up 0.7 percent from September's level. In addition, the RPI remained above 100 for the eighth consecutive month, which signifies expansion in the index of key industry indicators.
The Current Situation Index stood at 100.9 in October, up 1.0 percent. A majority of operators reported higher same-store sales, and two out of five reported stronger customer traffic. Fifty-seven percent also said they had made a capital expenditure in the past three months.
The Expectations Index also stood at 100.9, up 0.4 percent from September. Operators' outlook for sales growth in the months ahead remains cautiously optimistic, and a majority plan to make capital expenditures in the next six months.
Latest RPI Report Latest RPI News Release
The RPI is measured in relation to a steady-state level of 100. Index values above 100 indicate that key industry indicators are in a period of expansion, while index values below 100 represent a period of contraction for key industry indicators. The Index consists of two components – the Current Situation Index, which measures current trends in four industry indicators (same-store sales, traffic, labor and capital expenditures), and the Expectations Index, which measures restaurant operators' six-month outlook for four industry indicators (same-store sales, employees, capital expenditures and business conditions).
The RPI is based on the responses to the National Restaurant Association's Restaurant Industry Tracking Survey, which is fielded monthly among more than 400 restaurant operators nationwide on a variety of indicators including sales, traffic, labor and capital expenditures. Restaurant operators interested in participating in the tracking survey, contact Bruce Grindy.
More detailed data and analysis can be found on Restaurant TrendMapper (subscription required).
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PRAYER TO THE BLESSED VIRGIN: (Never known to fail). Oh most beautiful flower of Mt. Carmel, fruitful vine splendor of heaven. Blessed Mother of the Son of God, Immaculate Virgin, assist me in my necessity. Oh, Star of the Sea, help me show me herein, you are my Mother. Oh Holy Mary, Mother of God, Queen of Heaven and Earth! I humbly beseech you from the bottom of my heart to succor me in this necessity. There are none that can withstand your power. Oh, show me herein you are my mother. Oh Mary, conceived without sin, pray for us who have recourse to thee. Holy Mother, I place this cause in your hands (3X). Holy Spirit, you who solve all problems, light all roads so that I can attain my goal. You who gave me the divine gift to forgive and forget all evil against me and that in all instances in my life you are with me. I want in this short prayer to thank you for things as you confirm once again that I never want to be separated from you in eternal glory. Thank you for your mercy towards me and mine. The person must say this prayer 3 consecutive days. After 3 days, the request will be granted. This prayer must be published after the favor is granted. ¢ K.K.
Catholic Golden Age To Meet on Sunday For Talk on Patriotism
SCOTCH PLAINS ¢ The Scotch Plains Chapter of Catholic Golden Age will meet this Sunday, November 21, at 1:30 p.m. at St. Bartholomew the Apostle Roman Catholic ChurchÆs Nelligan Hall, 2032 Westfield Avenue in Scotch Plains.
The program, entitled ōPatriotism,ö will be presented by Post Commander Patrick Gargano of the Veterans of Foreign Wars. Guests are welcome.
The groupÆs annual Christmas Party will be held on Sunday, December 12, at Pantagis Renaissance in Scotch Plains. Members are also reminded to bring donations for the Food Bank.
For more information, please call John at (908) 322-1804 or Charlie at (908) 889-2152.
Church Sets Seminar On Estate Planning
WESTFIELD ¢ The Stewardship Committee of the First United Methodist Church, 1 East Broad Street in Westfield, has announced a free seminar on estate planning and annuities to be held on Friday, December 3, at 8 p.m. in the Fellowship Room. Members of the community are invited to attend.
Richard Bier, an attorney with the firm of St. John and Wayne in Newark, will make a presentation on estate planning. Richard Griggs, of Benefit Services Company, will discuss annuities and answer questions concerning insurance.
To register for the seminar, please call the church office at (908) 2334211.
St. PaulÆs Episcopal Church Reveals Choir Openings SWEET HARMONYģThe Junior Choir of St. PaulÆs Episcopal Church in
Westfield is pictured singing at the parishÆs All Saints Service on October 31. While there is a waiting list for the Junior Choir, openings presently exist in the churchÆs Primary Choir (grades 1 and 2) and the Parish Choir, made up of high school students and adults.
WESTFIELD ¢ St. PaulÆs Episcopal Church in Westfield is seeking singers to join a multi-generational music program at the parish.
More than 100 singers from St. PaulÆs and the community participate in the churchÆs music program.
Presently, there is a waiting list for the Junior Choir (grades 3 through 6) but a few vacancies exist in the Primary Choir (grades 1 and 2). St. PaulÆs childrenÆs choirs rehearse on Tuesdays after school and are beginning rehearsals for St. PaulÆs Christmas Eve Family Service.
The Parish Choir (high school students and adults augmented with professional section leaders) rehearses on Thursday evenings and
Interfaith Singles Set Sunday Meetings During November
WESTFIELD ¢ Interfaith Singles, a support group for single adults over 45, has announced its program schedule for the month of November.
Weekly discussions on successful single living are held at the First Baptist Church, 170 Elm Street in Westfield. Continental breakfast is offered for a $2 donation.
The group will meet on Sundays, November 21 and 28, from 9 to 10:30 a.m.
For further information, please call (908) 889-5269 or (908) 889-4751.
A Weekly Column From Members of the
Scotch PlainsFanwood Ministerial Association
Thanksgiving Day Holiday Is a Time to Give Thanks
Thanksgiving is perhaps one of the familyÆs most festive days throughout all of America. Roast turkey, stuffing, mashed potatoes, our favorite vegetables, pumpkin pie, apple cider and cranberry sauce. All of this is great, but surely Thanksgiving, in the true sense of the word, should mean a whole lot more than this.
Every Sunday morning when I stand before the congregation to declare the unsearchable riches of GodÆs Divine Word, one of the very first things I proclaim in a very firm, audible and assuring way is ōGod is good!ö The entire congregation invariably responds ōAll the time!ö Volumes are said in these small, yet potent, expressions of joy and thanksgiving.
In Psalm 116:12 King David inquires, ōWhat shall I render unto the Lord for all of his benefits towards me?ö Then in Psalm 50:14, he responds to his own inquiry; ōI will offer unto God thanksgiving; and pay my vows unto the most High.ö
How do you say thank you when someone shows you a kindness? Do you buy them a present? Do you send them a card? Do you make that special telephone call? Do you just ignore it completely? In each instance you usually attempt to express your feelings of gratitude in some noticeable way.
Our customs usually dictate that those of us who are recipients of acts of kindness should respond at least by saying, ōthank you.ö This is an expected cordiality, whether it is heartfelt or otherwise. Saying thank you is easy for some, but there are others who find it to be considerably
more difficult, simply because they find gratitude to be a humbling experience.
We, as a God fearing people, should always relish, yearn for and then seek after a genuine spirit of gratitude. God never promised that ours would be a utopian type society, and yet we need to learn how to thank Him for all of the circumstances of our lives. We need to thank Him for the sunshine and the rain; for our ups and our downs.
We can learn to thank Him for our joys and our pains; for our losses and our gains; with this assurance that God is good, and that He will never leave us to fend alone for ourselves. Knowing we have a God on whom we can always depend, thatÆs enough for which we should pause and say ōThank you.ö
But when we chose to give thanks to our God for His goodness, the emphasis should always be on the spirit demonstrated in our offering rather than on the offering itself. So as we approach the last Thanksgiving Day in the old millennium of the 19th century, we are all obliged to give God thanks out of our gratitude for His goodness towards us.
A genuine spirit of humility is far more important than a multitude of outward empty expressions. When the Almighty God has been so good to us, it really should not be too difficult for us to give Him all of the thanks, the honor and the praise. That thanks should always come from our hearts and not from our heads.
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Reverend Porter serves as Senior Pastor of St. JohnÆs Baptist Church in Scotch Plains.
has openings for altos, tenors and basses.
The Parish Choir performs annually in concert with members of the New Jersey Symphony Orchestra and is now preparing for St. PaulÆs Christmas Eve Service, as well as its annual Advent Lessons and Carols Service with chamber orchestra on Sunday, December 19.
For more information, please call Charles Banks at (908) 232-8506, Extension No. 17. St. PaulÆs Church is located at 414 East Broad Street in Westfield.
Westfield Firefighters Conduct Fourth Annual Food Drive
WESTFIELD ¢ The Westfield FiremenÆs Mutual Benevolent Association (F.M.B.A.) Local No. 30 is currently conducting its fourth annual holiday food drive for needy Westfield residents and has extended appreciation to all who participated in last yearÆs program.
Non-perishable food items will be accepted at fire headquarters at 405 North Avenue, West, until 9 p.m. on
Saturday, December 18. Donations will be distributed to individuals in need through local churches and civic organizations in time for the Christmas holiday.
During its first food drive in 1996, Local No. 30 distributed holiday meals to approximately 75 families in Westfield. Local No. 30 donated one turkey to each meal distributed and will do so again this year.
Hadassah to Hold Program On WomenÆs Mental Health
WESTFIELD ¢ The next general meeting of Westfield Hadassah will be held on Monday, November 22, at Temple Emanu-El, 756 East Broad Street in Westfield.
The program will be presented by Nicole Dickinson and Shannon Horvath from the Women Helping Women Group in Metuchen. Both women are completing their practicum
training with that organization. Their program will be entitled ōWomen Hold Up Half the Sky Ś How Mental Health Issues Affect Women.ö
Ms. Dickinson and Ms. Horvath will give a brief overview of the history of womenÆs mental health and the signs and symptoms of anxiety and depression. They will also tell how both impact an individualÆs life and what can be done about them. A question-andanswer period will follow their presentation.
Women Helping Women is a nonprofit organization which provides services such as individual counseling, therapy groups and support groups that focus on and encourage the empowerment of women.
Ms. Dickinson has been working in the area of womenÆs mental health, with a focus on domestic violence and crisis intervention, for seven years.
Besides womenÆs mental health, Ms. Horvath has a special interest in working with developmentally disabled children and young adults.
CYCLING SCOUTSģMembers of Boy Scout Troop No. 79, based at St. HelenÆs Roman Catholic Church in Westfield, recently earned the Cycling Merit Badge by completing the final requirement, a 50-mile bicycle ride. For safety reasons, the boys did a 10-mile loop five times in the Sandy Hook National Recreational Area in late September. The badge also entailed two rides each of 10, 15 and 25 miles. The scouts also learned how to change flats and do other minor repairs to their bicycles. Pictured, left to right, are: Merit Badge Counselor Bob Eckman, Jon Russell, Keith McCloskey, Robbie Eckman, Joseph Pregenzer and Scoutmaster Jim McCloskey.
Children of Interfaith Council Enjoy DECA Halloween Bash
SCOTCH PLAINS ¢ The Scotch Plains-Fanwood High School DECA Chapter, an association of marketing students, recently sponsored its eighth annual Halloween Party for the children of the Interfaith Council of Union County.
DECA students provided over 60 children with costumes, helped them paint their pumpkins, played games,
HAPPY HALLOWEENģChildren of the Interfaith Council of Union County are pictured during the Scotch Plains-Fanwood High School DECA ChapterÆs eighth annual Halloween party, which was held recently at St. MarkÆs Episcopal Church in Plainfield.
and went trick or treating. The party was held at St. MarkÆs Episcopal Church in Plainfield.
ōThese children are really special; we all had a great time and it was a great experience for us,ö said DECA Chairwoman Jackie Sanders. The students are planning another holiday party for the children in December.
Mayor Thomas Jardim Issues Proclamation for French Week
BON JOURģMayor Thomas C. Jardim, center, presents a proclamation designating November 4 through 10 as National French Week to teachers and students of French at Westfield High School (WHS). Joining the Mayor, pictured left to right, are: Melissa Tirone, French Club Treasurer; Kate Trimble, French Club Vice-President; Viviane Levy, President of the New Jersey Chapter of the American Association of Teachers of French (AATF); Marie-Laure Hollander, Vice-President of the AATF New Jersey Chapter and a WHS French teacher, and fellow WHS French teachers Nancy Didier and David Davis, holding his son.
WESTFIELD ¢ Mayor Thomas C. Jardim of Westfield signed a proclamation November 9 declaring November 4 to 10 as National French Week, or ōLa Semaine du Francais.ö
A few days earlier, Governor Christine Todd Whitman signed a similar proclamation.
National French Week is sponsored by the American Association of Teachers of French (AATF), which has 76 chapters and 11,000 members nationwide.
During that week, teachers of French and their students celebrate
the contributions of the French people and French-speaking countries to American history, literature, art, music, film, sciences and technology, fashion, sports and cuisine among other fields.
Westfield High School students have celebrated and publicized French language and culture during that week and have also been visited by Eric Sacher, Cultural Attache to the French Embassy in New York City.
First Baptist Church Offers PastorÆs Class
WESTFIELD ¢ Dr. Robert L. Harvey, Senior Minister of the First Baptist Church in Westfield, is holding a free PastorÆs Class from 9:15 to 10 a.m. on Sundays through December.
The PastorÆs Class is an exploration class about the nature of God. It references the Bible, historical understandings of the faith and the experiences of participants to probe who and what God is.
Like all educational opportunities at First Baptist, the class is open to the public. The church is located at 170 Elm Street. For more information, please call (908) 233-2278.
Division of Aging Reveals Services Available to Seniors
ELIZABETH ¢ Union CountyÆs Division on Aging in the Department of Human Services has announced its Outreach Services Program schedule for November. The program is open to all senior citizens living in Union County.
ōThe Union County Freeholders provide a variety of vital services to senior citizens through our outreach program,ö said Freeholder Lewis Mingo, Jr., Liaison to the Union County Advisory Council on Aging.
Applications for various services will be available at the following dates, times and locations:
Ģ Monday, November 22, at the OÆDonnell-Dempsey Center, 632 Salem Avenue in Elizabeth, from 10:30 a.m. until noon.
Ģ Monday, November 29, at the Calvary Baptist Church, 324 Monroe Avenue in Plainfield, from 10:30 a.m. until noon.
County representatives will be on hand to provide assistance in completing the necessary applications for Gas and Electric Support (LIFE LINE), Pharmaceutical Assistance (PAAD), Home Energy Assistance (HEAP), Supplementary Security Income (SSI), Counseling on Health Insurance for Medicare Enrollees (CHIME) and the SHARE Food Program.
For further information on the Outreach Services Program and other programs offered by the Union County Division on Aging, please call the divisionÆs toll-free number, (888) 2808226.
www.goleader.com | firstname.lastname@example.com | Copyright Covering Fanwood, Mountainside, Scotch Plains and Westfield, Union County, New Jersey (NJ) |


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Positively Aware Online News Brief. Current HIV News and events
Truvada receives FDA approval for the prevention of HIV
Potential Cause of HIV-Associated Dementia Revealed
Needle Exchange Survey Results Available
Berry Premieres Blog on Huffington Post
Truvada receives FDA approval for the prevention of HIV
Today, the FDA approved the medication Truvada for use in lowering the risk of HIV infection in individuals who are at high risk of infection. According to a press release from the FDA, "Truvada is to be used for pre-exposure prophylaxis (PrEP) in combination with safer sex practices to prevent sexually-acquired HIV infection in adults at high risk. Truvada is the first drug approved for this indication."
The FDA said Truvada for PrEP should be used as part of a comprehensive HIV prevention plan that includes risk reduction counseling, consistent and correct condom use, regular HIV testing, and screening for and treatment of other sexually-transmitted infections, stating that "Truvada is not a substitute for safer sex practices."
Currently, Truvada (a fixed dose combination of emtricitabine/tenofovir disoproxil fumarate) is one of the most widely prescribed HIV medications in the country, combined with other antivirals to create a treatment regimen. Truvada now carries a Boxed Warning on its drug label alerting health care professionals and uninfected individuals that Truvada for PrEP must only be used by people confirmed to be HIV-negative before being prescribed the drug and tested at least every three months during use to reduce the risk of developing drug resistant HIV-1 variants. Both the antiviral and the PrEP dose is one pill taken once daily.
Truvada maker Gilead Sciences worked with the FDA to create a Risk Evaluation and Mitigation Strategy (REMS) for Truvada PrEP. The REMS focuses on a prescriber training and education program in counseling and managing individuals who are taking or considering Truvada for PrEP, looking at the important elements of a comprehensive HIV prevention strategy, the importance of adhering to the recommended daily dosing regimen, and the serious risks of taking Truvada for PrEP if already infected with the virus or of becoming infected with HIV while taking it.
The FDA based its approval on the efficacy and safety demonstrated in two large, randomized, double-blind, placebo-controlled clinical studies, iPrEx and Partners PrEP.
As a condition of approval, Gilead Sciences is required to collect viral isolates from individuals who become infected with HIV while taking Truvada and evaluate them for the presence of drug resistance. The company is also required to collect data on women who become pregnant while taking Truvada for PrEP and to conduct a study evaluating drug adherence and its relationship to adverse events, risk of HIV infection, and the development of drug resistance in people who become infected.
"Today's decision is the culmination of almost 20 years of research involving investigators, academic and medical institutions, funding agencies and nearly 20,000 trial participants around the world, and Gilead is proud to have been a partner in this effort," said Norbert Bischofberger, PhD, Executive Vice President, Research and Development and Chief Scientific Officer, Gilead Sciences. "This advancement in the field of HIV prevention was made possible due to the leadership and commitment of the FDA and the Department of Health and Human Services to reduce the number of new HIV infections in the United States and worldwide."
Researchers at Georgetown University Medical Center appear to have solved the mystery of why some patients infected with HIV, who are using antiretroviral therapy and show no signs of AIDS, develop serious depression as well as profound problems with memory, learning, and motor function. The finding might also provide a way to test people with HIV to determine their risk for developing dementia.
They say the answer, published in the July 11 issue of the Journal of Neuroscience, may ultimately lead to a therapeutic solution that helps these patients as well as others suffering from brain ailments that appear to develop through the same pathway, including those that occur in the aged.
"We believe we have discovered a general mechanism of neuronal decline that even explains what happens in some elderly folks," says the study's lead investigator, Italo Mocchetti, PhD, professor and vice chair of the department of neuroscience at Georgetown University Medical Center. "The HIV-infected patients who develop this syndrome are usually quite young, but their brains act old."
The research team found that even though HIV does not infect neurons, it tries to stop the brain from producing a protein growth factor called mature brain derived neurotrophic factor (mature BDNF). Mocchetti says mature BDNF acts like food for brain neurons and a reduced amount results in the shortening of the axons and their branches that neurons use to connect to each other. When they lose this connection, the neurons die.
Mocchetti believes that HIV stops production of mature BDNF because that protein interferes with the ability of the virus to attack other brain cells. It does this through the potent gp120 envelope protein that sticks out from the viral shell—the same protein that hooks on to brain macrophages and microglial cells to infect them. "In earlier experiments, when we dumped gp120 into neuronal tissue culture, there was a 30-40% loss of neurons overnight. That makes gp120 a remarkable neurotoxin," he explained.
This study is the product of years of work that began when Mocchetti and his colleagues were given a grant from the National Institutes on Drug Abuse to determine whether there was a connection between the use of cocaine and morphine, and dementia. When they found that it was the virus that was responsible for the dementia, not the drugs, they set out to discover how the virus was altering neuronal function.
Their scientific break came when the researchers were able to study the blood of 130 women who were enrolled in the 17-year-old, nationwide WIHS (Women's Interagency HIV Study), which has focused on the effects of HIV in infected females. In one seminal discovery, Mocchetti and colleagues found that when there was less BDNF in the blood, patients were at risk of developing brain abnormalities. He published this finding in 2011 in the May 15 issue of AIDS.
In this study, Mocchetti, Alessia Bachis, PhD, and their colleagues studied the brains of HIV-positive patients who had developed HIV-associated dementia before they'd died. They also found that neurons had shrunk, and that mature BDNF had substantially decreased.
Normally, neurons release a long form of BDNF known as proBDNF, and then certain enzymes cleave proBDNF to produce mature BDNF, which then nurtures brain neurons. When uncut, proBDNF is toxic, leading to "synaptic simplification," or the shortening of axons.
"HIV interferes with that normal process of cleaving proBDNF, resulting in neurons primarily secreting a toxic form of BDNF," Mocchetti explains. "The link between depression and lack of mature BDNF is also known, as is the link to issues of learning and memory. That's why I say HIV-associated dementia resembles the aging brain."
The findings suggest a possible therapeutic intervention, he adds. "One way would be to use a small molecule to block the p75NTR receptor that proBDNF uses to kill neurons. A small molecule like that could get through the blood-brain barrier.
"If this works in HIV-dementia, it may also work in other brain issues caused by proBDNF, such as aging," Mocchetti adds.
The finding also suggests that measuring proBDNF in HIV-positive patients may provide a biomarker of risk for development of dementia.
"This finding is extremely important for both basic scientists and physicians, because it suggests a new avenue to understand, and treat, a fairly widespread cause of dementia," Mocchetti says.
Needle Exchange Survey Results Available
Results of the 2010 National Survey of Syringe Exchange Programs are now available by clicking here. The survey is the only source of national data on syringe exchange in the U.S.
The survey was made possible with the support of Beth Israel Medical Center, the American Foundation for AIDS Research (amfAR), and the Elton John AIDS Foundation.
This is also a reminder that the 2011 National Syringe Exchange Survey is currently underway. The survey is used to inform policy makers and advocates, and is especially important in the effort to reverse the ban on federal funding for syringe exchange. The survey can be found here.
Not only is this an opportunity to make drug user health a priority, but Beth Israel will send you a $75 incentive payment when you submit your survey.
Berry Premieres Blog on Huffington Post
Positively Aware editor Jeff Berry has joined other AIDS activists and journalists such as The Body's Kellee Turrell, the AIDS Foundation of Chicago's David Munar, and others in becoming a blogger published by The Huffington Post.
In advance of the upcoming AIDS 2012 World AIDS Conference, Berry wrote "Reflections from an Epidemic: Carrying the Torch to AIDS 2012." In it, he talks about the significance of this being the first conference to be held in the U.S. since President Obama lifted the travel ban on HIV-positive people, his anticipation of such events as displays of the AIDS Memorial Quilt, a planned march and demonstration, the performance of the Tony Award-winning play The Normal Heart, as well as the many global leaders in AIDS policy, advocacy, and treatment advances that will be presenting at the conference.
As a long-time activist himself, Berry also looks forward to a necessary re-dedication of the efforts of advocates to keep fighting against the disease. As he puts it, "I will continue to fight for all of those who are no longer with us, for those who are still with us but who have no voice, and wage war against the apathy and complacency around us that makes our work at times an uphill battle."
Click here to read the entire blog and stay tuned for Berry's live coverage of the conference, along with other PA staff, on Facebook, Twitter, and in the September/October issue of Positively Aware.
Red Ribbon Show Benefits Camp Starlight
On July 8 at the Southside Speakeasy & Dance Pub in Salem, Oregon, there was a packed house for the 5th annual Red Ribbon Show to raise money for Camp Starlight, an Oregon summer camp for children affected by HIV/AIDS, a program of Cascade AIDS Project.
The event included a drag and variety show featuring performers from across the Northwest, as well as silent and live auctions and a raffle. This year's event also received support from openly HIV-positive celebrities Jack Mackenroth (Project Runway), Olympian Greg Louganis, who donated autographs for the auction, and Styx bassist Chuck Panozzo, who sent in a signed electric guitar.
The Red Ribbon Show, established in 2007 by former Mr. Gay Oregon Jonathan Reitan, has raised nearly $20,000 for a variety of HIV/AIDS organizations and $8,600 was raised this year for Camp Starlight.
"The Red Ribbon Show is not just about raising money, it is about encompassing the entire umbrella of HIV/AIDS and how it affects our communities," said Reitan. "It is about awareness, it is about prevention, it is about support. I am only one voice, but together we can and will make a difference."
Democratic Representative Barney Frank tied the knot with his longtime partner Jim Ready on July 7, becoming the first member of Congress to enter into a same-sex marriage.
The wedding, which was held in Newton, Massachusetts, and officiated by Governor Deval Patrick, was attended by 300 family and friends, according to a statement from Frank's office.
Frank, who was the first openly gay member of Congress, announced in November 2011 he would retire after 16 terms in the House. In January, he announced his plans to marry Ready in his home state, which is one of six to have legalized same-sex marriage.
"I think it's important that my colleagues interact with a married gay man," Frank had said in an interview with New York magazine. "I do think, to be honest, if I was running for re-election, I might have tried to put the marriage off until after the election, because it just becomes a complication," Frank added. "But I did want to get married while I was still in office."
Frank had joked before the wedding that President Obama would not be invited citing security concerns. "If he and Michelle wanted to come, I would be delighted and honored to have them, but he will bring the Secret Service," Frank said in January. "I don't want to be accused of having shut down the entire region for a five-mile radius on a holiday weekend."
Fallout from the Supreme Court's ruling on the ACA continues. The vote on July 11 represented the House's 33rd attempt to kill the Affordable Care Act (ACA) either wholly or in part. As predicted, this repeal effort, like all the others, passed the House, this time with a 244-185 vote, including five Democrats from "vulnerable" districts who voted for it. The five hours of "debate" over two days, along with the vote itself, have been called "political theatre," since the Senate will not bring the bill up for a vote and even if they did and it passed, President Obama has said he'd veto it. But there was a new twist of hypocrisy added to the reports on this vote.
Repealing the health care law would let members of Congress keep their government-subsidized insurance coverage after they retire—a benefit they lost under Republican Senator Chuck Grassley's amendment to the ACA, which kicked members of Congress and their aides out of the healthcare program for federal employees. Instead, lawmakers and staff would have to get coverage through the insurance exchanges created by the healthcare law. Grassley, displaying the courage to go against his party, said it ensures that lawmakers live under the same rules as their constituents.
"The message to grassroots America is that health care reform is good enough for you, but not for us," Grassley said last year, defending his amendment.
Before the Affordable Care Act became law, members and their staffs bought insurance through the Federal Employees Health Benefit Program (FEHBP). They would return to the FEHBP if the law is repealed.
The FEHBP allows government employees to keep their policies after they retire. People who get insurance through a private employer, however, often lose their coverage when they lose their job or change jobs, yet another problem that would be solved by single-payer health care.
The FEHBP is widely regarded as one of the country's more successful health care programs. Federal employees can choose from a range of plans that meet certain minimum standards. The federal government subsidizes its employees' coverage, just like any other large employer.
Insurance companies are eager to participate in the FEHBP because it offers them access to a large pool of potential customers, just as the individual mandate and the insurance exchanges under the new law are meant to do.
Also ACA-related, HR 6097, the Religious Freedom Tax Repeal Act, was introduced by Republican James Sensenbrenner Jr. on July 10. The ACA requires that most employers cover birth control without a co-pay for employees. Under the GOP bill, employers that object to birth control for religious reasons can refuse to cover it without facing financial penalties from the government.
Sensenbrenner's bill would erase the taxes faced by employers who choose not to cover certain healthcare benefits "by reason of adherence to a religious belief or moral conviction." Those who oppose the bill, and others like it in the past, have argued that the broad criteria of "moral conviction" could lead employers to deny prescription drug coverage to those with HIV or other STIs, coverage to same-sex couples in states where gay marriage or civil unions are legal, and drug and alcohol abuse treatment to addicts.
Though alarming scenarios have been presented of churches and religious schools and hospitals being "taxed out of business," the fact is that churches and houses of worship have always been exempt from the mandate altogether, while religious-affiliated institutions don't have to pay for the coverage through their own plans—their employees will instead get contraception directly from the insurer, still without a co-pay.
No co-sponsors have been added to any of the bills we're keeping an eye on. There are 40-some days left in this Congress in which they could actually get things done, but if they insist on spending all their time on trying to defeat the ACA and denying women their reproductive rights, it seems unlikely that one single job will be created or one dollar added to the economy due to Congressional achievement. No wonder their approval rating is nearing single digits.
Are you registered to vote? Do you live somewhere where politicians are trying to take away voting rights or where millions are being spent trying to buy your vote? Show them you won't be stopped or bought. Register. Do your homework. Find out the facts. Vote. There is no excuse not to.


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The Counseling Center Testing Office is responsible for the administration, scoring, and maintaining of records for a wide range of tests administered to students at the University of Oregon. The Testing Office works closely with the student population by disseminating information, advising students, and administering exams.
December 6th, 2013. Due to the weather, the University of Oregon is closing at 2:00 p.m. today. If you have an appointment scheduled this afternoon, please call us Monday to reschedule. 541-346-3230.
ATTN: LSAT Candidates:
If you are registered for the LSAT tomorrow, Dec. 7, 2013, please be advised that there is the real possibility that the test will be canceled due to the weather. Please check this web page in the morning for any updates. You can also call the Testing Center, 541-346-3230, to listen for any updates. If the test is canceled, Law Services will contact you by email regarding options.
Placement testing is now open for Winter 2014 registration. Online registration opens for placement testing on Monday, Nov. 4th for appointments beginning Monday, Nov. 11th.
A $10 fee will be charged for the following tests:
The GED test will undergo a major change beginning Jan. 2014. Anyone who has begun their GED but not yet finished will need to do so by Dec. 31, 2013 or they will need to start over from the beginning. GED candidates are now able to combine test scores from the paper and pencil version with the computer based version. This allows for greater access and incresed opportunities for passing the GED. More information about the 2013 close out campaign can be found at the State GED program web site.
HOURS: Mon., Tues., Wed., & Fri. 8:00 AM - 5:00 PM Thursday 11:00 AM - 5:00 PM
Fees for Distance Ed. proctoring are accepted by cash or check only and payable on your test date.
LOCATION: Room 270, University Health, Counseling and Testing Center building Maps and Directions


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Enjoy free shipping both ways this holiday season. If for some reason you are not completely satisfied with your purchase, choose our FREE pre-paid shipping label and we'll cover your return! This offer is only good on eligible orders placed between November 13, 2013 and December 24, 2013. We've extended our normal return period to January 15, 2014 or 30 days after your order is received - whichever comes later. Learn more about our return policy.
Shop now and get Free Value Shipping on most orders over $29.95 to contiguous 48 states, DC and to all U.S. Military APO/FPO/DPO addresses.
American Hunter Traditional Feeder Funnel T-F3055 fits most 30, 35 and 55 gallon barrels. By using the pre-punched holes and self-tapping screws, the diameter of the funnel can be adjusted for your deer feeding barrel. For more Hunting Accessories from American Hunter, please visit our American Hunter Hunting Accessory page.


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Brian Cohen, field organizer at the Camarillo Democratic headquarters, shares pictures with Laura Perez, a volunteer, on Thursday evening.
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There weren't many voters in Ventura County back in 1920, but they were a solidly Republican bunch. In the presidential election that year, Warren Harding won 80 percent of the Ventura County vote. That was the start of a remarkable, nearly unbroken, string of 24 presidential elections in which Ventura County voters have been in sync with national political sentiment. In only one instance over the past 92 years have Ventura County voters sided with a loser — in 1976, when they picked Gerald Ford over Jimmy Carter.
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§ Mr. Peter Walkerasked the Minister of Transport when she will announce her estimate of expenditure on new road construction and major improvements on a year by year basis from 1967–68 to 1970–71.
§ Mr. SwinglerFigures for 1967–68 will appear in the printed Civil Estimates and my right hon. Friend hopes before very long to make an announcement about expenditure during a further period of years. Following previous practice she does not propose to announce individual estimates of expenditure for intervening years.
§ Mr. Berryasked the Minister of Transport if she will give details of the reductions made in estimates for road expenditure in Greater London for the years 331W 1967–68 and 1968–69, respectively, showing separately new construction with major improvement, and maintenance with minor improvement, as a result of the House of Commons Paper 252 of 1966–67 on Local Government Finance (England and Wales) published on 15th December, 1966.
§ Mrs. CastleThe figures given in Appendix A of the White Paper for relevant expenditure on highways, road lighting and road safety are 12.1 per cent. lower than the corresponding estimates submitted by local authorities generally for 1967–68 and 10.6 per cent. lower for 1968–69.
These figures are calculated as aggregates and are not attributable to individual authorities. They make full provision for carrying out local authorities' road programmes previously approved.


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Quality Concrete Construction Awards Program
In 2000 the CAWV and WV Division of Highways created the "Quality Concrete Construction" Awards Program.
The program is designed to recognize and reward superior workmanship and performance, stimulate competition among contractors and ensure that quality construction in the highway program remains a focus of the industry to the ultimate benefit of the public.
Categories include structural work and flat work. The structural project category is comprised of bridges, retaining walls, precast concrete or any other specialty structural concrete construction.
The Concrete Quality Excellence Awards are presented each year at the State Meeting held during Expo.
The CAWV would like to congratulate Ahern, a Division of Kokosing Construction, on winning the Structural Work Category for the Keyser-McCoole Bridge. Flat Work Category awards were presented to Hi-Way Paving, Inc. for their work on Route 48/Corridor H in Grant County and Golden Triangle Construction Company for the Charles Town Route 9 Bypass. For more information, see the May/June issue of West Virginia Construction News.
Entries are accepted in the Winter months. Forms will be available here during the application period.
Judges: Todd Rumbaugh, director of Contract Administration - WV Division of Highways; Mike Mance, cement and concrete unit supervisor - WV Division of Highways; and Bert Buchanan, bridge engineer - Federal Highway Administration


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Though I have smoked a pipe for many years, I have only a few tobaccos under my belt. Like the FOG's of days gone by, I found the tobaccos that suited me and kind of stayed with them. My cellar is limited to about six standard blends and a few more of my floor blends.
I want to ween myself of dips and chews and figure a good full body and strength tobacco might give me the nic kick I'll need to get off the chew.
As a reference, I am now rotating through five to ten year old Nightcap, a couple of G.L. Pease blends, Adagio #50, W.O. Larsen blends and Revelation.
So,,, what I may be looking for is a powerful non or very light aromatic that can relieve my craving for a dip or chew.
What say you pipers, will this help and what would you recommend???
One last thought, I did smoke cigarettes for about 25 years while smoking the occasional cigar and a bowl or two a day. I gave up the cigs twenty years ago almost cold turkey but just can not seem to get away from the dip and chew.


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Here we go again. Another guy that's so good it's hard to comprehend. Auby stacks clips and had a full edit of amazing VX footage laying around. He's a true street ripper but special mention for his sick ledge work.
MORE VIDEOS OF:Auby Taylor |
Tampa Am Tampa, FL Dec 08 |
King of New York Premiere New York, NY Dec 09 |
Baker Boys Christmas Demo Los Angeles, CA Dec 17 |


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Tips For Effective Affiliate Marketing On Your Blog
Niche blogs are usually created to make money. For blogs just starting out it may be difficult to sell enough advertising space to earn an income. In this case, most bloggers turn to affiliate marketing. An affiliate product is a product created by someone else who agrees to split the profit of every item you sell with you. You are responsible for marketing the item and luring people to buy. There are several ways you can do this without a website or blog but it is much easier and more likely to work when you have one.
There are a number of techniques that can increase your affiliate sales from your blog including writing detailed reviews, using a designated page on your site, writing articles to lure people to your product, and limiting the affiliate products on your sites to only ones that are related to the niche topic.
Using Reviews To Sell
Writing a review of a product is probably the best way to make an affiliate sale. However it can be tricky since you really shouldn't review something you haven't used and it can be expensive to buy everything you want to sell. Occasionally the creator of the product will offer you the chance to try the product in return for a well-thought out and honest review. Beware of the people who demand a positive review because if the product turns out to be a real dud, you're reader will lose faith in your opinion.
Aside from honesty, your review should include a detailed description of the product, the benefits of the product to the buyer, and any pros and cons that you feel would be useful to someone trying to decided if they should buy. If you are recommending the product, include an affiliate link somewhere towards the end of the review. Don't paste your link throughout the review or your readers may feel that you are only trying to push a product.
Use Designated Pages
A designated page is one designed entirely for one product. By creating a designated page you can direct your traffic immediately to the product you are trying to sell. This avoids the chance that your prospective customer won't be able to find your affiliate link among the other links, posts and ads on your blog.
When creating a designated page remember that your sole purpose for that page is to sell that one product. Not to recommend other sites, other products or other advertisements. Keep the page simple and clean. Although most marketers recommended lengthy sales pages, I find it more effective to try and sum everything up so that the reader doesn't have to scroll down to finish reading. As a side note, although you may be sending traffic directly to this page, remember to include a link to this page on your homepage.
Choosing Topic- Related Products
Limit your affiliate products to ones that are related to the niche. While you may be tempted to include unrelated products that are good sellers or high priced, your readers will appreciate it more if you sell only the type of things they came to your site to buy. Finding niche products is relatively easy. You can go to sites like Clickbank and Commission Junction, which offer many hundreds of affiliate programs to marketers and register as an affiliate for free. Simply type your niche or a related keyword into the convenient search box to have instant access to niche-appropriate products. Alternatively you can type your niche or keyword into Google with a "+ affiliate" (no quotes though) after it and find affiliate programs that are not part of other affiliate networks.
While the methods mentioned in this article will give you a head start to being a successful affiliate marketer, there are many other, more advanced techniques out there to improve your affiliate sales. Remember that part of being an Internet Marketers is to be always researching ways to make your business better!


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Make a trip to Grand Cayman Island where you will snorkel with the sting rays, cruise with swashbuckling pirates, and swim with the wolves. :)
I'm at:
Vampire Romance Books!
for a giveaway.
Review of A Howl for a Highlander from Romance Review Books--
Terry Spear does it yet again. Howl for a Highlander brings us the story of Duncan MacNeill, one of the hunky Highland wolf quadruplets we met in Heart of a Highland Wolf. Duncan has left his homeland for Grand Cayman Island and is hunting down the thief that stole his family's fortune. With a single plan on his mind he has no desire to play tourist while on the island. Little did he know his plans would be sidetracked by the sexy little she wolf Shelley Campbell as soon as he departed the plane. Sensing a female wolf all alone, well, what could any self respecting male do but make sure she was protected and entertained. Tracking down the thief and protecting Shelley from an over amorous wolf doesn't keep the two of them from finding a little time to enjoy the beautiful island. As with every Terry Spear novel, her descriptive writing draws you into the story and you'll feel like you're on the island right along with Duncan and Shelley. With just the right amount of romance, humour, and suspense Howl for a Highlander showcases everything we've come to love of Terry Spear. Each and every character comes with a story all their own and make their way into the hearts of the readers, not to be forgotten. Terry Spear has a seamless way of bringing characters together whether they run the forests in America or the ageless castles in Scotland, you never know who's going to show up in a future book. If you aren't already a fan of Terry's, Howl for a Highlander will win you over and have you running to read about the rest of her wolves. From Highlanders, SEALs, and everything in between, no one writes sexy alpha wolves like Terry Spear. And still a chance at winning at Casablanca Authors! Casablanca Off to get this posted so everyone has a chance to visit the sites and comment! Hope you all have a lovely Monday. Roofers are coming to give me estimates today. Hopefully no rain in forecast (usually I NEVER say that due to months of lack of rain around here), and they get the job done soon. Any plans for this bright new week? Terry "Giving new meaning to the term alpha male where fantasy IS reality!"
About Terry
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Traditions and the History of Art Speaker Series continutes with a lecture by Dr. Peter Schultz
Thursday, February 21, 2013 - Thursday, February 21, 2013
Event Notes:
Lecture and reception are free and open to the publc. O'Shaughnessy Educational Center is handicap accessible. Accessibility requests: (651) 962-6315. Parking is available in the Anderson Parking Facility, corner of Grand and Cretin avenues. www.stthomas.edu/campusmaps
For additional information call (651) 962-5560.
Dr. Peter Schultz, Olin J. Storvick Chair of Classical Studies, Department of Art at Concoredia College, Morehead, Minnesota, is presenting the 3rd lecture in the Traditions and the History of Art Lecture Series. His lecture is titled, Style, Continuity, and the Hellenistic.
Sculpture of the Hellenistic period, specifically "Hellenistic baroque," is often characterized as a revolutionary break with previous Greek traditions. Dr. Schultz argues that the conventional view of Hellenistic baroque as "new," "innovative," or "revolutionary" obscures an important historic reality: Namely, aspects of the Hellenistic baroque are firmly rooted in a stylistic tradition that extends directly back to sculpture of the fifth and fourth century B.C.E. in Athens. This "classical" pedigree of the "Hellenistic" style has ramifications regarding how the "baroque mode" was used by Hellenistic sculptors. Most importantly, this reconsideration of the "baroque tradition" allows for interesting speculation as to what Baroque sculpture might have meant to the artists, patrons and communities that made, purchased and consumed it.


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Mon. Final: Brewers 9, Cubs 6PHOENIX (AP) -- Jeff Samardzija had one more start to prove he deserved serious consideration for the Cubs' starting rotation. He likely made manager Lou Piniella's decision easy. Bill Hall hit a three-run homer off Samardzija, who gave up five runs in the first inning after getting the first two outs, and the Milwaukee Brewers beat Chicago 9-6 on Monday. Piniella plans to begin revealing the Cubs' rotation later this week after giving everyone one more start and Samardzija most likely will be in the bullpen because of the emergence of left-hander Sean Marshall as the leading candidate to be the fifth starter.
Samardzija went 1-0 with a 2.28 ERA in 26 relief appearances last season for the Cubs and said he'd be happy in any role. "I don't know what's going to be next for me, but obviously I'll be ready to pitch. I've said before I don't mind pitching whenever or wherever. I'll just be ready to go whenever they call my name," Samardzija said. "I really don't have a preference, like I said with my pitches and everything and where they're at, I'm pretty happy with them, so I feel like I'll leave it up to the upstairs to make a decision what they feel is best for the team." Samardzija's problems began when J.J. Hardy doubled with two outs in the first. Hardy scored when Prince Fielder hit a towering fly to right field that Micah Hoffpauir couldn't grab at the warning track. Fielder slid headfirst into third for a triple and was awarded home when second baseman Mike Fontenot's relay throw ended up in the Cubs' dugout. Corey Hart doubled and Mike Cameron walked in front of Hall, who is looking to bounce back from a disappointing season and missed the first four weeks of spring training with a torn muscle in his left calf. The drive was another good sign for Hall, who only hit .174 against right-handers last year. That forced the Brewers to platoon him with Russell Branyan, who signed a free-agent contract with Seattle in the offseason. "He's just getting into the swing of things," manager Ken Macha said. Brewers starter Dave Bush again looked strong, allowing one run and six hits with a walk in four innings. He worked out of a bases-loaded jam in the fourth. Bush has given up four runs in 14 innings over five spring appearances, good for a 2.57 ERA. "When they had the bases loaded, no outs, it gives you an opportunity to try to make pitches in a situation that's going to come up sometimes on you," said Bush, who is working on being less emotional during his starts. "With bases loaded and no outs, the tendency sometimes for me is to try to get three outs on one pitch." Samardzija worked a scoreless second before departing. He was charged with five runs and five hits with two walks. Hart homered off Jeff Stevens in Milwaukee's three-run third. Aramis Ramirez hit a solo home run in the sixth and Welington Castillo added a three-run shot in the eighth for the Cubs. (Copyright 2009 by The Associated Press. All Rights Reserved.) Notes:@ Cubs OF Milton Bradley was scratched from the lineup and sent home with the flu. ... Brewers RHP Braden Looper threw two innings in a simulated game. Looper, who has been sidelined with a strained oblique muscle, took a glancing line drive off the back of his head in his first inning, but said it didn't faze him and he finished the outing. "I felt great today physically, even if I wasn't as sharp as you would like," Looper said. ... The Brewers decided to let LF Ryan Braun (strained rib cage) stay with the United States in the World Baseball Classic. Braun is day to day. |


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Jafrum online knows that a true biker always has a good solid pair of engineer boots in their collection, therefore we carry several brands of these classic boots including River Road, Icon, and Joe Rocket to name a few. The engineer boot is known as the "only true motorcycle Boot" and has been around since the 1930's. It got the name engineer boot from the land surveyors who originally wore the boot. The engineer boot is a biker favorite distinguished by their solid leather frame steel toe and silver or brass buckle at the ankle and around the top of the boot. Here at Jafrum online we have just what you need at the lowest most affordable prices.
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RATINGS: 1699 WEIGHTED AVG: 3.55 SEASONAL: Winter EST. CALORIES: 165 ABV: 5.5%
COMMERCIAL DESCRIPTION This is our special ale from the brewers at Anchor. It is sold only from early November to mid-January. The Ales recipe is different every year, but the intent with which we offer it remains the same: joy and celebration of the newness of life. Since ancient times, trees have symbolized the winter solstice when the earth, with its seasons appears born anew. Editors Note: due to the significant similarity in style and strength from year to year (despite potential differences in the exact spice blend), this beer is no longer separated by vintage.
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