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Semaphorin Signaling
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Full Text | PDF (111 kb) - 14-3-3ε Couples Protein Kinase A to Semaphorin Signaling and Silences Plexin RasGAP-Mediated Axonal ...
14-3-3ε Couples Protein Kinase A to Semaphorin Signaling and Silences Plexin RasGAP-Mediated Axonal Repulsion
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Taehong Yang and Jonathan R. Terman
SummaryThe biochemical means through which multiple signaling pathways are integrated in navigating axons is poorly understood. Semaphorins are among the largest families of axon guidance cues and utilize Plexin (Plex) receptors to exert repulsive effects on axon extension. However, Semaphorin repulsion can be silenced by other distinct cues and signaling cascades, raising questions of the logic underlying these events. We now uncover a simple biochemical switch that controls Semaphorin/Plexin repulsive guidance. Plexins are Ras/Rap family GTPase activating proteins (GAPs) and we find that the PlexA GAP domain is phosphorylated by the cAMP-dependent protein kinase (PKA). This PlexA phosphorylation generates a specific binding site for 14-3-3ε, a phospho-binding protein that we find to be necessary for axon guidance. These PKA-mediated Plexin-14-3-3ε interactions prevent PlexA from interacting with its Ras family GTPase substrate and antagonize Semaphorin repulsion. Our results indicate that these interactions switch repulsion to adhesion and identify a point of convergence for multiple guidance molecules.
Summary | Full Text | PDF (2954 kb) - Semaphorin signaling: progress made and promises ahead
Semaphorin signaling: progress made and promises ahead
Trends in Biochemical Sciences, Volume 33, Issue 4, 1 April 2008, Pages 161-170
Yeping Zhou, Rou-Afza F. Gunput and R. Jeroen Pasterkamp
AbstractSemaphorins were initially characterized according to their role in repulsive axon guidance but are now recognized as crucial regulators of morphogenesis and homeostasis over a wide range of organ systems. The pleiotropic nature of semaphorin signaling and its implication in human disease has triggered an enormous interest in the receptor and intracellular signaling mechanisms that direct the cell-type-specific and diverse biological effects of semaphorins. Recent breakthroughs in our understanding of semaphorin signaling link integrin and semaphorin signaling pathways, identify novel ligand–receptor interactions and provide insight into the cellular and molecular bases of bifunctional and reverse signaling events. These discoveries could lead to therapeutic advances in axonal regeneration, cancer and other diseases.
Abstract | Full Text | PDF (849 kb) - …more
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Copyright © 1998 Cell Press All rights reserved.
Cell, Volume 95, Issue 7, 903-916, 23 December 1998
Add/View Comments (0)Plexin A Is a Neuronal Semaphorin Receptor that Controls Axon Guidance
Margaret L Winberg1, Jasprina N Noordermeer1, Luca Tamagnone2, Paolo M Comoglio2, Melanie K Spriggs3, Marc Tessier-Lavigne4 and Corey S Goodman1, ∣∣, *,
1 Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA
2 Department of Molecular Oncology, Institute for Cancer Research, University of Torino Medical School, I-10060 Candiolo, Torino Italy
3 Department of Molecular Biology, Immunex Corporation, 51 University Street, Seattle, Washington 98101, USA
4 Department of Anatomy and Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA
- The Semaphorins comprise a large family of secreted and transmembrane proteins, some of which function as repellents during axon guidance. Semaphorins fall into seven subclasses. Neuropilins are neuronal receptors for class III Semaphorins. In the immune system, VESPR, a member of the Plexin family, is a receptor for a viral-encoded Semaphorin. Here, we identify two Drosophila Plexins, both of which are expressed in the developing nervous system. We present evidence that Plexin A is a neuronal receptor for class I Semaphorins (Sema 1a and Sema 1b) and show that Plexin A controls motor and CNS axon guidance. Plexins, which themselves contain complete Semaphorin domains, may be both the ancestors of classical Semaphorins and binding partners for Semaphorins.


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They don't live with their uncle
Written by Barbara
(9/27/2009 1:09 p.m.)
in consequence of the missive, The Stteele's home, penned by Bridget D
Lucy herself says "my sister and me was often staying with my uncle". She wouldn't say 'often staying with' if they actually lived with him. It is probable they spent a great deal of time there. A houseful of young men who were probably gentlemen's sons or sons of wealthy men would be a great place to have your young, single daughter frequently visit. When Edward came to see them just before going to Barton cottage, it is more likely he would visit Lucy at her uncle's than at her own home, as he has an excuse to be at Mr. Pratt's but none to be at the Steele home if their engagement is secret. |
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You can view the page at http://psx-scene.com/forums/content....-Support-Added
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thnx but when i update it says multiman is incoplete and if have some screen isseus i should update with base or full so i deleted multiman updated to release before this one 2.00.05 i believe and then update to latest i get same error. Is there a full version for this release?
i want psx support
This news does nothing but create confusion.The translation work is not yet complete, the link for the dowunload was made available only to users who work in translation, is not for everyone.The new version is released with multiple language support when all work will be completed.
yea cool i like it
hehe Bulgarian ,how cool even my language is there way to go dean
ohh yeah turkish language support
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Like a kid in a candy store: A dressed-down Courteney Cox hunts for homewares on her day off
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We were awarded the First in Farming "Ruminan Kecil" from Ministry of Agriculture & Agro-Based Industry in August, 2005. RISDA and PPK also held a course about Management of Jamnapari Breeding at our farm.
Our corporate goal is to produce the best quality of Jamnapari at the minimal cost.
The following pictures showed the process of Artificial Insemination (AI) done by our scientist.


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Partly sunny. Highs around 40. Southwest winds 10 to 15 mph with gusts up to 25 mph.
Mostly cloudy and not as cool. Near steady temperature in the mid 30s. Southwest winds 5 to 10 mph.
Partly sunny. Highs in the mid 40s. Southwest winds 5 to 10 mph.
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Mostly cloudy with a 50 percent chance of showers. Highs in the lower 50s. Temperature falling into the mid 40s in the afternoon.
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2012-03-23 09:05
Nuclear industry calls for greater role in security, safety
Global energy leaders on Friday called on the industry to take on a greater role in bolstering nuclear security and safety as the world must cope with the threat of natural disasters and terrorists elements.
In a joint nine-point statement announced at the two-day Nuclear Industry Summit in Seoul, 118 global atomic energy companies and international organizations outlined practical measures that can be pursued by the industry to enhance public confidence in fission power generation and ensure growth of atomic power down the road. The statement is to be recommended to leaders of 58 nations and international organizations who will participate in the 2012 Nuclear Security Summit scheduled for early next week, the state-run Korea Hydro & Nuclear Power Co. (KHNP), the event's organizer, said. Companies such as KHNP, France's Areva SA, China National Nuclear Corp. and the World Nuclear Association endorsed the promotion of an upgraded security culture and cooperation in research to develop a high density, low enriched uranium fuel for small research reactors. They also stressed support for International Atomic Energy Agency (IAEA) guidelines to cut back on the use of highly enriched uranium, countermeasures against cyber terrorism, exchange of best practices and integrated security and safety for nuclear installations and materials. Industry leaders added that close global cooperative dialogue must be maintained within the atomic energy sector, while established operators should take action to assist newcomers in nuclear power generation to follow the IAEA's recommendations for building the necessary infrastructure for safe and secure use of atomic energy. Beyond the official statement, industry experts said there may be a need for an independent safety organization to regulate the nuclear industry as a whole. In regards to taking all possible steps to strengthen nuclear security and safety, Korea's Prime Minister Kim Hwang-sik, who addressed the forum earlier in the day, said the country is fully committed to promoting the peaceful use of atomic power. "Seoul will share its accumulated knowledge and experience in the nuclear power sector with the international community," he said. The policymaker said the country, as a leading operator of nuclear power plants, will do its part to promote knowledge and information sharing between governments, businesses and the general public. The need for more information-sharing was echoed by Areva SA chief executive Luc Oursel and World Institute for Nuclear Security (WINS) executive director Roger Howsley. Both called for a free flow of information and said there is a need to do away with the excessive secrecy within the sector. Experts said following Japan's Fukushima nuclear power plant disaster last year, there is a pressing requirement to raise public confidence if the nuclear industry is to move forward. The Fukushima meltdown was triggered by a massive earthquake and ensuing tsunami, and is considered the worst nuclear accident since the 1986 Chernobyl tragedy. Oursel said while last year's disaster raised concerns about the safety of nuclear power, countries around the world have resumed reactor building projects. He predicted global nuclear capacity, which currently stands at 400 gigawatts, will grow to 600 gigawatts by 2030. He said the nuclear renaissance has not been seriously affected, although there has been renewed emphasis on safety and security. He said the French nuclear power company aims to invest 8 billion euros (11.97 trillion won) over the next five years to build up its capabilities and know-how, with a large portion set aside for atomic safety. The WINS official said threat of terrorism and natural disasters have raised the need for more coordination across the board. Howsley said with Korea transforming itself as a presence in the atomic power building sector, it has to dedicate more to the issue of safety and security. "South Korea and other countries must learn to think progressively on safety," he said, adding that the international organized by the International Atomic Energy Agency (IAEA) in 2008, will start a concerted training program in 2013. The program could augment Seoul's existing safety program run by the Korea Institute of Nuclear Nonproliferation and Control, he said. Following the official debate sessions, KHNP president Kim Jong-shin said in a press conference that the industry summit represents a positive move to build up global security and safety in the nuclear field to counter threats posed by terrorism as well as natural disasters. He also said that the industry continues to learn from mistakes from the Three Mile Island incident in 1979 to the recent Fukushima tragedy, and most recently, the mishap at South Korea's Gori-1 that was shut down earlier this month. The Gori incident was caused by technicians mistakenly cutting power to a reactor and then concealing the breakdown of an emergency generator in February. The KHNP, meanwhile, said 200 participants were present for the industry summit from energy companies from around the world and international agencies including the IAEA, the Nuclear Energy Agency, the World Association of Nuclear Operators and the World Nuclear Association. South Korea said that the industry summit is expected to allow the international community to gauge the strength of South Korea's atomic power industry and highlight the importance of nuclear energy safety, the KHNP said, adding it could also promote Seoul's efforts to export its knowhow in nuclear power generation. Korea which first started operating a commercial nuclear reaction in the late 1970s currently has 21 units in operations with seven under construction. The country sealed a deal with the United Arab Emirates a nuclear power plant for the Middle East country. (Yonhap) |


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This film takes you inside the famous Jazzkeller Frankfurt during the sound check for Jon Hammond Band
on the occasion of their annual "Musikmesse Warm Up Party" celebrating 25 years Musikmesse with
Tony Lakatos tenor saxophone
Joe Berger guitar
Giovanni Gulino drums
Jon Hammond XB-2 Hammond organ
Jon's band run down the following tunes: Skylark, Somewhere Over The Rainbow, Sugar, Blues In The Night,
Days of Wine and Roses, Cannonball '99...One More Time!, Lydia's Tune bossa nova, Cosmo Lane
Special thanks Messe Frankfurt Projekt and Presse Team, P.Mauriat Saxophones, Hammond Suzuki Musical Instruments, Camera: Jennifer,
Eugen Hahn Jazzkeller Frankfurt Team, Jon's amplifier TecAmp Puma Combo bass amp Jürgen Kunz,
Thomas Eich TecAmp / THC-Amps, Joe Lamond NAMM, Bernie Capicchiano, Michael Falkenstein, Hiromitsu Ono, Waichiro 'Tachi' Tachikawa,
See you next year 2012! Jon Hammond Band
Sound Check Film Jon Hammond Band
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Ah, the cut-offs. They're back along with Tobias and the rest of the AD crew. Finally. We're calling it now: Cut-offs will be the biggest trend of summer 2013. We're serious.
(No, of course we're not serious.)
Check out the rest of the posters at Empire.
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Fibrocystic breasts are composed of tissue that feels lumpy or rope-like in texture. Doctors call this nodular or glandular breast tissue.
It's not at all uncommon to have fibrocystic breasts. More than half of women experience fibrocystic breast changes at some point in their lives. In fact, medical professionals have stopped using the term "fibrocystic breast disease" and now simply refer to "fibrocystic breasts" or "fibrocystic breast changes" because having fibrocystic breasts isn't really a disease.
Although breast changes categorized as fibrocystic breasts are normal, they can cause breast pain, tenderness and lumpiness — especially in the upper, outer area of your breasts. Breast symptoms tend to be most bothersome just before menstruation. Simple self-care measures can usually relieve discomfort associated with fibrocystic breasts.
It's important to have your breasts evaluated if you have specific areas where pain continues to occur or worsens, or if you have new areas of lumps or thickening that persist after your period. Your doctor will examine you to see if the new changes are concerning and to eliminate other causes.
Read more about fibrocystic breasts.
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Our patients tell us that the quality of their interactions, our attention to detail and the efficiency of their visits mean health care — and trusted answers — like they've never experienced.
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Ten Inbox Secrets, how eye tracking helps you to create more successful emails is a study of over 50 emails from 8 market sectors.
Dispelling the myths surrounding starting a business and showing how common assumptions can get in the way. After reading, you will be able to grow your business in a predictable and productive way.
Effective Internet marketing requires that you test and optimize your landing pages to maximize exposure and conversion rate. This is a comprehensive guide to increasing conversions and improving profits.
A comprehensive demonstration of how Web sites actually work when users need specific answers, researched and compiled by User Interface Engineering.
Brainfluence explains how to practically apply neuroscience and behavior research to better market to consumers by understanding their decision patterns.
Learn how Cook – An American Express Travel Representative used conversion rate optimization to dramatically lift both phone calls to its agents and online form-fills on its paid search landing page.
Discover the Five Steps to a Successful Conversion Optimization Strategy that delivers dramatic lift in leads, sales and revenue.
This describes how people are connected, and how ideas spread through social networks. It shows businesses how to rebuild around social behavior, and create products that people tell their friends about.
This book outlines standards-based strategies for building designs that can accommodate the myriad ways users choose to view the content.
This book is valuable tool in helping you to understand the range of factors to take into consideration in designing and building a personalized user experience.


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"He who does not have the church as his mother does not have God as his Father.
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"Saint Augustine Quotes." Quotes.net. STANDS4 LLC, 2013. Web. 10 Dec. 2013. <http://www.quotes.net/quote/10282>.


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ALBANY (AP) -- Former New York Gov. Mario Cuomo said Sunday that church leaders should be cautious about pressuring Catholic politicians over issues such as abortion because people might not vote for someone they think is guided by religion.
Cuomo's comments came as Rhode Island Rep. Patrick Kennedy sparred with a bishop over his public stance on moral issues including abortion. Kennedy said Bishop Thomas Tobin has asked him not to receive communion.
In a 1984 speech, Cuomo, a Catholic and Democrat who supported abortion rights and was at the time a leading potential presidential candidate, delivered a speech at the University of Notre Dame explaining that Catholic lawmakers shouldn't be pressured by church leaders to work for anti-abortion legislation.
"The American people need no course in philosophy or political science or church history to know that God should not be made into a celestial party chairman," he said then.
On Sunday, he said it's dangerous for the church to pressure politicians because of the potential for unintended consequences.
"If you're required (by the church) to make everybody follow your Catholic role, then nobody would vote for Catholics because it's clear that when you get the authority, you're going to be guided by your faith," the former governor told The Associated Press.
Cuomo said there are two positions a politician can take: They can oppose church doctrine outright or, as he did, accept church teachings personally but refuse to carry them into the public arena where they would affect people of every faith.
"Don't ask me to make everybody live by it because they are not members of the church," Cuomo said. "If that were the operative rule, how could you get any Catholic politician in office? And would that be better for the Catholic church?"
Cuomo, who in 1984 had just delivered a soaring speech at the Democratic National Convention that vaulted him to the top of the list of future presidential candidates, said he understands why church leaders target a high-profile officeholder such as Kennedy.
"I think the bishops would say, 'Yeah, the better known the name, the more effective what I'm trying to do here,"' Cuomo said.
Still, he thinks there are more bishops around the country who have declined to call out politicians than those, like Tobin, who have. He wouldn't say which is the better path.
"Not for me to tell a bishop what to do," he said.
Cuomo tangled frequently with the church during three terms as governor. Former New York City Cardinal John O'Connor in 1990 warned that Roman Catholic officials who support abortion rights could face excommunication.
"Where Catholics are perceived not only as treating Church teaching on abortion with contempt, but helping to multiply abortions by advocating legislation supporting abortion, or by making public funds available for abortion, bishops may decide that ... such Catholics must be warned that they are at risk of excommunication," wrote O'Connor.
(Copyright ©2009 by The Associated Press. All Rights Reserved.)


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Slideshow: New Sires of 2014
A visual look at some of the new sires for 2014, arranged in in alphabetical order. View Slideshow
Trainer | Claude R. McGaughey III |
Jockey | Joel Rosario |
Owner | Phipps Stable and Stronach Stables |
Breeder | Phipps Stable |
Point of Entry View Five-Cross Pedigree | Dynaformer | Roberto |
Andover Way | ||
Matlacha Pass | Seeking the Gold | |
Our Country Place |
No auction history found.
A visual look at some of the new sires for 2014, arranged in in alphabetical order. View Slideshow
Frank Stronach's Adena Springs Farm announced Nov. 7 the 2014 stud fees for their Kentucky stallion roster including new stallions Point of Entry and Fort Larned.
Five-time grade I winner Point of Entry arrived at Adena Springs Kentucky the morning of Nov. 7 and was settling in well, according to general manager Eric Hamelback.
Irish-based Magician took advantage of a fast early pace to roll to victory in the $3 million Breeders' Cup Turf (gr. IT) at Santa Anita Park Nov. 2.
This year's Breeders' Cup Turf (gr. IT) features a rematch of the first two finishers in 2012, Little Mike and Point of Entry, but the road back to Santa Anita Park Nov. 2 has been anything but smooth for either horse.
Hall of Fame trainer gives an update on his Breeders' Cup contenders and Kentucky Derby winner Orb. Shug also discusses Point of Entry and Hymnbook. watch video
Little Mike, back on the beam after a slow start to the 2013 campaign, is set to defend his title against a solid field of domestic and foreign entrants in the $3 million Breeders' Cup Turf (gr. IT) Nov. 2.
The best of the best will be on display at Santa Anita Park Nov. 1-2, with the leading trainers in the United States and Europe pre-entering a star-studded array of talent for the Breeders' Cup World Championships.
Five-time grade I winner Point of Entry sailed along his road to recovery from a condylar fracture suffered in early June, and is on track for a comeback in the Breeders' Cup Turf (gr. IT). read blog
Five-time grade I winner Point of Entry delivered a solid move in company over the Belmont Park inner turf course on Oct. 13, going five furlongs in 1:01.24 to stay on track for a comeback in the Breeders' Cup Turf (gr. I).
Trainer Shug McGaughey said Aug. 20 that the Phipps Stable's Point of Entry had his first gallop since being injured and he is confident the colt will make it back for the Breeders' Cup Turf (gr. IT).
Although Point of Entry will not defend his title in the $600,000 Man o' War Handicap at Belmont Park July 13, Hall of Fame trainer Shug McGaughey hopes Boisterous will be a capable pinch-hitter in the grade I turf event.
A look back on the career of John Velazquez, as he records his 5,000th NA win. View Slideshow
Phipps Stable's Point of Entry, winner of the Woodford Reserve Manhattan Handicap (gr. IT) June 8, suffered a condylar fracture in his left hind cannon bone and will have surgery, trainer Shug McGaughey said.
All the action leading up to the big race on Belmont Stakes day. View Slideshow
Phipps Stable's Point of Entry captured his eighth victory in 12 starts on grass with a smooth come-from-behind win in the $500,000 Woodford Reserve Manhattan Handicap (gr. IT) at Belmont Park June 8.
As fans started to trickle into Belmont Park on Saturday, June 8 for the Belmont Stakes (gr. I), the sun began to peek through scattered clouds as more than 24 hours of rain had finally halted.
Trainer Shug McGaughey said emphatically that turf star Point of Entry will compete in the $500,000 Woodford Reserve Manhattan Handicap (gr. IT) June 8, despite the forecast for rain over the weekend.
Horse of the Year Wise Dan ran his winning streak to six races and surpassed $4 million in career earnings handily in the Woodford Reserve Turf Classic (gr. IT) over yielding ground May 4 at Churchill Downs.
At 3:20 p.m. Saturday, May 4, Churchill Downs officials announced Phipps Stable and Stronach Stable's Point of Entry had been scratched from the $500,000 Woodford Reserve Turf Classic Stakes (gr. IT).
Wise Dan and Point of Entry face off May 4 at Churchill Downs in the $500,000 Woodford Reserve Turf Classic (gr. IT), the race immediately preceding the Kentucky Derby (gr. I).
Orb, winner of the Besilu Florida Derby (gr. I), heads the NTRA Top 3-Year-Old Poll that came out April 29 in advance of the May 4 Kentucky Derby Presented by Yum! Brands (gr. I).
A face-off between 2012 Horse of the Year Wise Dan and multiple grade I-winning turf star Point of Entry is on for the Woodford Reserve (gr. IT) on Derby Day, trainer Charlie LoPresti confirmed April 29.
Trainer Rudy Rodriguez put his skills as a former rider to use on Tuesday, April 23, riding grade II winner Vyjack on the Churchill Downs main track in preparation for the Kentucky Derby presented by Yum! Brands (gr. I).
Recent allowance winner Orb will likely run Feb. 23 in the $400,000 Besilu Stables Fountain of Youth Stakes (gr. II) at Gulfstream Park, providing that he pleases trainer Shug McGaughey in a workout scheduled for Feb. 18.
Rachel Alexandra |
Bodemeister |
Shared Belief |
Honor Code |
Will Take Charge |
Mucho Macho Man |
Orb |
Game On Dude |
Wise Dan |
Ria Antonia |


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Retailers Fight Shoplifting, Fraud With Higher-Tech Tools
Add Comment
Read Comments
Posted By:
Alex Kecskes
In: Fashion and Retail
If you're a
retail executive
, you know that fraud, theft and similar losses threaten your bottom line. A study conducted at the end of last year by the
Centre for Retail Research
estimated that shoplifters, vendor fraud and deceitful employees cost U.S. retailers $8.9 billion during the holiday season.
The good news is that annual losses dropped $3.5 billion from those recorded in 2008. Security professionals say retailers have added more guards and anti-theft technology—measures that were trimmed when the recession hit. "It's a combination of things. We're seeing more money spent on loss prevention. That's been notching up every year," said
Richard Mellor
, vice president for Loss Prevention at the Washington-based National Retail Federation.
Security measures, like hiding anti-theft alarms in products and sales data software that uncovers fraud, have helped cut losses. So have inventory logs and video systems, which catch shoplifters and dishonest employees. There's also better information sharing between retailers and police agencies that can put the finger on suspects before a theft is committed. "Retailers are paying more attention to what shrinkage means to the bottom line," said
Dan Reynolds
, former vice president of North American Sales and Customer Service for
Checkpoint Systems
While these crime countermeasures are beginning to pay off, organized crime rings continue to pose a challenge for retailers. A
National Retail Security Survey
revealed that 96 percent of retailers suffered at the hands of professional thieves in 2011, looting up to $12 billion. Crossing state lines, these professional pilferers will distract employees to steal consumer goods that are easily fenced online. Checkpoint notes that goods targeted most often include trendy clothes, alcohol, hot toys, upper-end perfumes, popular DVDs, watches and fancy chocolates.
To beat thieves at their own game, stores have designed some pretty sophisticated ways to catch them. One tool used by high-end retailers is the
mannequin. Developed by Italian mannequin maker Almax, the $5,130 mannequins feature a camera in one eye. While overhead cameras proliferate in most retail stores, EyeSee offers an eye-level-view of potential thieves. Used together with facial recognition software, the mannequins can identify thieves already in police criminal databases.
Almax Chief Executive Officer
Max Catanese
says several companies currently use "a few dozen" EyeSee mannequins in three European countries and the US—with several more dozen already on order. In addition to providing added security, data collected by the mannequins has already helped shops adjust window displays, store layouts, and promotions to keep consumers spending. Catanese says that EyeSee mannequins can't store images, so any retailer with a closed-circuit television license can use them.
Retail executives faced with excessive shrinkage now have a number of anti-theft tools at their disposal-- everything from simple anti-theft alarms to $5,130 EyeSee mannequins.
Image courtesy of africa/FreeDigitalPhotos.net
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One Direction star Harry Styles recently spent thousands of dollars on takeaway pizzas and drove around Los Angeles distributing them to the homeless.
The generous singer made the gesture last year during the band's trip to California on his only day off from work, according to fellow British singer Ed Sheeran.
The "Lego House" hit-maker insists his friend deserves some credit for his efforts to help the needy, telling American radio station 95.5 WPLJ, "I saw him in L.A. about three months ago. He had a day off and he went out. ... No one knows about this. ... He went out on his day off and spent like two or three grand on Domino's pizzas and drove around for the whole day just giving it to homeless people.
"I think that's an amazing story. That's pretty cool right? ... People write about Harry all the time in a negative way with all his love life and stuff, but he does stuff like that a lot. ... He's actually a pretty genuine dude. ... Harry only came into this huge amount of wealth in the past two years, so he doesn't take it for granted at all. He's really generous and likes feeling like he does some good in the world."
Chris Brandon, a spokesperson for the Domino's Pizza chain, has since spoken out to thank Styles for his kindness, saying, "All we really want to say though is thank you to Harry for involving us in such a cool thing that he did. My understanding is that Harry and One Direction have plenty of fans. ... But they certainly gained a bunch more today from us here at Domino's."
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Well lets get on with this freak show shall we... Since most everyone on here sounds like a broken record, I'll try and not make this profile like that, although that is easier said than done.
I'll start with the basics, my name is John, although my friends refer to me by my last name (We knew too many John's growing up). I am 26 years young and am trying my best.
I will not tell you about who or what I think I am or am not, I will leave that for you to find out for yourself if you are interested. Instead I will just tell you what I enjoy in hopes that we have some common ground to talk about. I think a list format will work best for this...
•Sleeping in on the weekends.
•Riding my motorcycle out in the country.
•Restoring my grandpa's old boat from 1965.
•Being outside doing things and stuff.
•Driving... some of the time.
•Catching up with old friends.
•People watching while trying to decipher their conversation.
•Building potato launchers and other random things.
•Having some sort of a project to work on.
•Dr. Pepper
•Yogurt covered pretzels
•That first cut into a fresh sheet of construction paper
•Shooting off fireworks in inappropriate places
•Driving around aimlessly
•The occasional mischief and/or Mayhem
Maybe I should also list things that I wish to do/accomplish in my life time...
•Travel all over the US and the world
•scuba diving
•have a workshop where I can build things
•Finish my boat and visit as many bodies of water as I can with it
•Go fast, very fast
•Play in thick snow
•Drive a steam roller over a long line of bubble wrap.
* I'll update this as I go
BTW, does anyone else find it kind of funny that if the match percentage is below a certain amount it says "Y'all got issues" or is that just me???


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BP & Exercise
Find a Conversation
BP & Exercise
Wed, 07-06-2011 - 10:15am |
Maybe you all will know the answer here (or have some good guesses).
Wed, 07-06-2011 - 8:05pm |
That IS a great question, and I would love to know what her doctor tells her, as well.
Thu, 07-07-2011 - 7:01pm |
I went to the doctor today and decided to ask her about this since I was there (note that she is an internist and not a cardiologist). She said that a good way to measure "strength" when you're on betas is to measure your resting heart rate. If it's getting lower, that means your heart is getting stronger. She was a bit more sketchy though about the rest of it. So, a bit more information... :)


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Senators are threatening to stall passage of the multi-year fiscal budget of US$649.72 million under deliberations at the Capitol Building unless President Ellen Johnson Sirleaf fulfill their recommendation to dismiss Acting Mayor Mary Broh of the Monrovia City Corporation (MCC).
"If the President insists [to maintain] Mary Broh as the Acting Mayor of the MCC, we will not pass the budget. This is the magnitude to which we speak, ladies and gentlemen," Sen. John Whitfield (Grand Bassa County) told plenary where she failed to appear following repeated citations.
The Senate passed a vote of "no confidence" on Ms. Broh Tuesday for her "continuous failure" to appear before them for inquest on allegations of her "persistent brutality" against peaceful citizens, including an employee of the Senate.
Prior to the decision Tuesday, Sen. Whitfield accused Ms. Broh of showing continuous "disrespect" to them as lawmakers in the country.
Sen. Whitfield described Mrs. Broh as "an anarchist functioning under the pretext of a city administration. She believes she is too big to be questioned."
"She goes into the suburbs making women to pump tire; she has youths creeping and insulting their own parents. And in her own City Hall, she has the audacity to tell her employees how nasty they are," he recounted.
Whitfield: "I said it before and let me repeat; not a President, Vice President, Senator, Minister or anybody, the least to talk about, a little City Mayor, has the right to go out there and beat anybody. Nobody has that right."
"We need to tell Mary Broh that yes indeed we came here through the collective voice of the people and she was handpicked. Yes, she needs to know that she was handpicked. We will not sit here to celebrate Mary Broh slapping people," said Sen. Lahai Lansana, chair on the Senate Committee on Rules, Order and Administration.
Other Senators supported the move with Senator Abel Massaly regretting: "There is no need for the senate to have allotted money to her in the previous budget."


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A Model Family (Part 2)
Submitted by Negin Janati on November 4, 2011
Editor's Note: This blog post was co-written by Nothing But Nets team member Negin Janati and Kate Dodson, UN Foundation Director for Global Health. If you missed Part 1 of this story, read it here!
Sagude looked down to put his arm around his eight-year-old son, then looked back up to us and said "I understand you've come a long way to get here. I know you're from America, and that we have American generosity to thank for our healthy community. So I would just like to say thank you. Your support has not gone unnoticed."
Sagude Rafera lives in Gonbore, Ethiopia, a small village of just a few hundred people 3.5 hours southwest of the capital city of Addis Ababa. Six years ago, with support from the U.S. government, the Global Fund, and other donors, the Ethiopian government built a health post in Gombore, staffed with two trained Health Extension Workers. Since that time, the health post has provided a full range of preventative health services to Sagude and 5,000 others in their community, including bed nets and vaccines for measles, polio, meningitis, and other common childhood diseases. Thanks to those tools, the rate of childhood mortality in that district has dropped 58 percent in just the past three years.
With the "Model Family" program, families are seeing results. Sagude's family is of one of the earliest Model Families in the Wolliso district -- each of his children are fully vaccinated and sleep under a bed net each and every night. Sagude is working hard to get all of his neighbors on board with this system, and we asked him why. He gave me a simple answer: it's working. Not only does it work, but it's easy to make these changes. Sagude's family -- and now his entire village -- is healthier, with fewer cases of malaria and other diseases.
Sagude told me, "Please continue your support. It's helping our community stay healthy." Giving $10 to send a bed net to help protect families in Ethiopia like Sagude's is really the least we can do.
Send a net. Save a life. Together we can cover a continent.
Posted in Nothing But Nets Blogs » Negin Janati's Blog


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This is a story I was sent years ago. I'm not sure who wrote it. It seems important in these stress-filled days when we think being perfect is the answer to our problems.
A water bearer in China had two large pots, each hung on the ends of a pole which he carried across his neck. One of the pots had a crack in it, while the other pot was perfect and always delivered a full portion of water.
At the end of the long walk from the stream to the house, the cracked pot arrived only half full. For a full two years this went on daily, with the man delivering only one and a half pots full of water to his house.
The perfect pot was proud of its perfection and accomplishments. But the poor cracked pot was ashamed of its own imperfection, and miserable that it was able to accomplish only half of what it had been made to do.
After two years of what it perceived to be a bitter failure, it spoke to the water bearer one day by the stream. "I am ashamed of myself, and because this crack in my side causes water to leak out all the way back to your house."
The bearer said to the pot, "Did you notice that there were flowers only on your side of the path, but not on the other pot's side? That's because I have always known about your flaw, and I planted flower seeds on your side of the path, and every day while we walk back, you've watered them.
"For two years I have been able to pick these beautiful flowers to decorate the table. Without you being just the way you are, there would not be this beauty to grace my house."
Each of us is a cracked pot. But, it's the flaws we have that make our lives so very interesting and rewarding. You've just got to take each person for what they are, and look for the good in them. Especially yourself.
I will be exploring the dangers of perfectionism over the next few weeks and offer tips for breaking free from its stranglehold.


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Brothers Ben and Jon Campopiano didn't start their careers by just appearing out of a cornfield like Shoeless Joe Jackson does in every sports movie. Both Ben and Jon coached baseball at Northgate High School, where they led teams into the post-season and helped youth athletes hone their skills. Today, Ben works as the Director of Baseball Operations at Santa Clara University, and Jon serves as Northgate High School's Vice Principal. At Bronco Baseball Academy, they distill their years of expertise into weeklong camps for players aged 5–13 years. Along with their fellow baseball instructors, the brothers Campopiano lead drills and games that focus on all aspects of the game: throwing, catching, hitting, base running, and everything in between. They also work alongside a certified athletic trainer, who ensures players stay safe and healthy throughout each day of training.
Staffed by native East Bay trail explorers and expert riding instructors, Bella Oaks Stables fosters trained and fulfilling relationships between horses and their enthusiasts. Nestled among towering oak trees and gentle rolling hills, the fleet of majestic equines tote riders through lessons, community field trips, and trail rides, all under the guidance of a doting congregation of caretakers and volunteers. Seventeen summer camps for all ages and an apprenticeship program for more advanced riders instill saddle savvy in patrons of any experience level, and those pining for nature can meander through 80 miles of lush scenery and 1 mile of sci-fi-movie scenery for an afternoon trail ride.
An intro-to-sailing lesson with OCSC is designed both for beginners who can't tell a mermaid from Ethel Merman and for more-intermediate students of the stern and aft looking to perfect their technique. Skilled and certified instructors teach each lesson, while a low teacher-to-student ratio ensures plenty of attention and instruction for all involved. Your lesson will focus on practical training, creating a prime opportunity to get some on-the-water experience beneath your sails. Over the course of two hours, you'll be exposed to different roles and positions on the yacht, including the position of steely-eyed helmsman. By the end of the salt-sprayed session, you won't be a certified skipper, but you'll have had a sublime time and tasted the sailing experience, which always tastes like a combination of warm brownies and cold milk.
Gymboree offers a bevy of baby-engaging classes, in which parents and wee ones work together to build tots' creativity and encourage development through play. Weekly classes are available for every age from the freshly born sapling to the 5-years-young wise wanderer. This deal includes rhythm-building music classes, sports classes, imagination-expanding art classes, and Gymboree's most popular class, Play & Learn. The month-long membership allows you to take one class per week, with make-ups available during enrollment if you miss a class.
Adrienne Moore, a former nationally ranked All American swimmer, and her husband Stephen founded AquaTech Swim School to shepherd babies, children, and adults into the world of swimming. Their team of instructors spends 40 hours studying the Mattos method, named for Adrienne's maiden moniker, which combines swimming skills with child-psychology skills. The CPR-, AED-, and first-aid-certified teachers continue their education and hone their advanced Marco Polo calls throughout their time at the school. Private, semiprivate, and group classes for children range from 6-month-olds' Tadpole curriculum to the advanced, team-focused Orca course, and the eight levels of kids classes are nuanced to include both "nervous" and "comfortable" beginner levels. The instructors help grownups get kicking during 60- and 90-minute private classes.
The Concord location's brightly colored facilities include an 87-degree indoor pool that's 4 feet deep, pirate-free, and specially designed for classes. A lesson-viewing area includes bleachers and a play station, and free WiFi is available for visitors who would rather surf than swim.
In this parkour-based studio, improvisation is the name of the game as urban acrobats navigate a changeable maze of barriers, bars, and soft landing pads using practical and functional movements. Directed by a pro team originally based out of Boulder, athletes ages 7 and older scale sheer walls, spin in mid-air, and bounce from vertical surface to vertical surface. Before they attempt open gym sessions, beginners should start on introductory classes, during which they work on strength, agility, the art of falling, and explaining to citizens that they are not real superheroes.
A comprehensive guide to attractions and things to do.


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Manufacturer's Description
Experience the thrill of the hunt and live the dramatic life of a submarine captain like never before. Help to write a riveting chapter of World War II history by commanding accurately recreated German submarines in the Atlantic theatre of operations. (Includes the exclusive PBS documentary: Lost and Found Legacy of the USS Lagarto ). Make history by achieving objectives in a dynamic campaign and play through historical based scenarios. Every action of the player will have an impact on the following missions and the overall scenario development. Silent Hunter returns to the Atlantic to give the player the chance to control accurately recreated German submarines and satisfies the wish of the large simulation community!. Interact with the submarine crew and command the officers onboard watch them perform their daily jobs and experience the tension and fear inside the U-boat. For the first time walk through highly detailed submarines in FPS fashion. New level accessibility will cater to more casual simulation fans. New users will be able to play Silent Hunter: Battle of the Atlantic in easy mode and prowl the waters free of confusion or complication. Cinematic experience with improved environment graphics and highly detailed submarine models increases the level of realism and immersion in the game.
The Specs
Additional Specifications | |
Parent Retsku | B003ELPQJM |
Quick Glance |
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Membership in the largest desert racing community has its advantages
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awesome videos thanks for posting!
car porn.. and I'm not the only one that thinks so sccording to 3:22 into the first one... lol
LOOMISMotorsports | ORANGE ARMY | Camburg | Method Race Wheels | RADesigns | Ringers
Very cool vids! Love all the sounds; pinned motors, screeching tires, undercarriages dragging on the dirt.....and the orgasmic sounds from spectators.
Thanks for posting! That just made my morning!
Ringers Gloves, C&M Aluminum Foundry, FAST-Aid, Team Associated www.RC10.com, FAT Performance, DFT Trans, BFGoodrich Tires, McKenzies Performance, NTS, Bilstein Shocks, ZLT, Troy Lee Designs, LRH Hobbies
Thanks, reminds me of when I would rail my Carrera 911 out and back from the off road races when I had her!
War is peace, slavery is freedom? Listen to all, follow none!
With Politicians like these, who needs terrorists? - Ron Paul
I raced a vintage 1975 Porsche 911 in the East African Safari rally back in November. I was blown away about the capabilities of the car and how much abuse it would take (mine had full WRC suspension - doesn't look like these have). The only problem is in the mud with the engine way out in the back of the car the rear end would want to slide out on you. Had to be careful.
Baja Bound


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Pineapple/Pinecone FishesCritter Spotlight: Monocentrus japonicusPhoto Credit: Bob FennerThese fishes belong in the Order Beryciformes and Suborder Trachichthyoidei as members of the Family Monocentridae (Pineapple or Pinecone Fishes) consisting of 2 genera, and 3 species. These non-aggressive fishes are nocturnal and feed by attracting prey with a light organ that activates symbiotic phosphorescent bacteria. These organs are conveniently located on each side of the lower jaw. During the day, they are found in caves and venture out during the evening hours in search of food, usually small fish and shrimp. They are found in a broad range of depths, from shallow estuaries to depths over 600 feet. Their body is covered with strong plate-like scales and have spines in the dorsal and ventral fins that can be locked in an outward position when needed. Feedings should occur during evening hours. For in-depth information concerning these fishes, checkout Reef Fishes Volume 1 by Scott Michael (ISBN #1-890087-21-1). You can see a review of this exquisite book by visiting my Product & Book Reviews page. Please click on the species you are interested in viewing.
CleidopusMonocentrusSuitable for Reef Aquariums NOT Suitable for Reef Aquariums Suitable for Fish-Only Aquariums NOT Suitable for Fish-Only Aquariums Avoid this nuisance species! |


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Michizzle's Topics Activity
Welcome to my Nursing Profile Page! You can learn all about me here. Together, we can learn, share, and network with nurses and nursing students from all around the world. If you are not yet a member Register Now to gain more access.
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- March 29, 2011
- 1:09 p.m.
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Firestick writes:
The DUMBACRATS are afraid they might miss out on some multiple voting voters! TOO BAD!!!
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By Lynn Minnick
This post follows along the same idea as Cory Brewer's last post about relationships. My office has a new office leader/manager and she recently put together an event that I thought was pretty genius AND helped build relationships.
She asked each of us to provide her with a list of the different real estate service-related vendors we use and would recommend (home inspectors, exterminators, electricians, septic installers, radon guys, landscapers, mold specialists, handymen, home stagers, etc. — all the professionals we turn to on a regular basis in my market.) Then, for a small donation to our company charity, The Sunshine Kids, she offered each of them a table at a vendor fair we hosted. She invited all of the REALTORS® in our town and surrounding towns, and served refreshments.
The event itself was only about two hours long, but it allowed us to meet face-to-face with these professionals, make introductions, and network. I suppose it was kind of like speed dating. Some of the businesses were more experienced with vendor fairs and came prepared with lots of handouts, giveaways, and raffles, while others greeted us with simple business cards and conversations, relying solely on their long-standing reputations.
The event was easy to organize and very well-received. A win-win-win, really, for us, the vendors, and our favorite charity!
Lynn Minnick is a REALTOR® in Connecticut known for her love of all things international, organic, travel and design. Connect with her at thegreenctrealtor.blogspot.com or @LynnMinnick.
By Cory Brewer
Having a buddy who is a handyman, or a friend of a friend who paints in their spare time, is great…but trying to save a quick buck or two now could cost you, your brokerage, and your client a lot more down the road.
When prepping a home for the market or making inspection repairs, thoughtful consideration must be given to those who are hired to do the work. Movers, stagers, plumbers — they all fall into this category.
One recent example from my brokerage where this comes into play: A vendor was brought in to do some cleanup work in a top-floor condo unit of a multi-story building. Oops…he stepped on and broke sprinkler pipe up in the attic/roof space and damaged not only the unit he was working on, but the two units below as the water leak went wild. The insurance claim reached six figures and involved multiple home owners. Our brokerage policy is to only use vendors who are properly insured…and this is exactly why. This particular vendor came forward and processed the claim through his insurance.
Hiring someone on the cheap may sound good at first – especially when on a budget – but the time and money it costs to fix something that wasn't done right the first time can really add up. Scrutinize your vendors and make sure that they will stand behind their work. If anything goes awry, your clients will thank you for recommending the right people to work with.
Cory Brewer is a REALTOR® in the Seattle area and Operations Manager at Windermere Property Management / LGA in Bellevue. Connect with Cory at www.wpmnorthwest.com.