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SOURCE Sangamo BioSciences, Inc.
Reduction of Viral Load at or Below Limit of Detection Ongoing at 14 Weeks
Additional Presentations of Preclinical Data at Annual Meeting of European Society of Gene and Cell Therapy (ESGCT)
RICHMOND, Calif., Oct. 28, 2013 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today the presentation of new data demonstrating sustained control of HIV viral load (VL) at or below the limit of detection for 14 weeks (at last measurement) in an SB-728-T- treated HIV-infected subject who was not on antiretroviral therapy (ART). The CCR5 delta-32 heterozygote subject is enrolled in Sangamo's clinical trial (SB-728-902 Cohort 5) and, as part of the clinical trial protocol, is undergoing an ART treatment interruption (TI), which is ongoing.
(Logo: http://photos.prnewswire.com/prnh/20130102/SF35903LOGO)
Data were presented at the Annual Meeting of the European Society of Gene and Cell Therapy (ESGCT and SETGyC Collaborative Congress) which is being held in Madrid from October 25-28, 2013.
"These data demonstrate that sustained functional control of HIV in the absence of ART is possible with a single SB-728-T treatment," stated Geoff Nichol, M.B., Ch.B., Sangamo's executive vice president of research and development. "Our aim is to provide a population of immune memory cells that are protected from HIV infection and are capable of generating an effective immune response against the virus throughout the body. These data represent a further step toward demonstrating the efficacy and durability of this therapeutic approach."
Dr. Nichol added, "We continue to follow these Cohort 5 subjects and look forward to presenting a complete data set from this study, and a second ongoing trial (SB-728-1101), designed to maximize the engraftment of SB-728-T in subjects who are not CCR5 delta-32 heterozygotes, later this year."
Data from Sangamo's Phase 1 and 2 studies demonstrate that VL became undetectable during a TI from ART in three of seven evaluable CCR5 delta-32 heterozygote HIV-infected subjects, including two of six subjects that had completed TI in the ongoing SB-728-902 Cohort 5 study and an additional CCR5 delta-32 heterozygote subject from an earlier Phase 1 clinical trial of SB-728-T. In one SB-728-902 Cohort 5 subject, VL has remained undetectable (at or below the limits of quantification of the current ultra-sensitive assays for HIV) for 14 weeks (to last measurement taken) and the TI is ongoing. Reduction in VL from peak during TI showed a statistically significant correlation (p=0.015) with estimated numbers of engrafted ZFN modified cells (SB-728-T) in which both copies of the CCR5 gene had been disrupted (biallelic modification), in line with previously presented data from this program.
Collectively, data from these studies demonstrate that in all trial subjects, SB-728-T treatment results in a durable increase in total CD4 T-cells. In addition, seven of nine subjects enrolled in Sangamo's Phase 1 study (SB-728-902 Cohorts1-3) experienced a longer term reduction in the viral reservoir as measured by HIV DNA in peripheral blood mononuclear cells, a source of chronic HIV infection not addressed by current ART.
Sangamo scientists and collaborators also presented data from preclinical and research programs in hemophilia and lysosomal storage disorders, hemoglobinopathies, cancer, cystic fibrosis, immunodeficiencies and the application of ZFN-mediated CCR5 modification in stem cells for HIV.
"The presentations at the ESGCT meeting demonstrate the diversity and breadth of potential therapeutic applications of Sangamo's ZFP technology," said Edward Lanphier, Sangamo's president and CEO. "We look forward to continuing to update on our progress in the coming months at a translational medicine meeting organized by The Lancet entitled, 'What Will it Take to Achieve an AIDS-free World?' in San Francisco, from November 3-5, as well as at the Sixth International Workshop on HIV Persistence, Reservoirs & Eradication Strategies in Miami in early December. In addition, we will present data from Sangamo's preclinical programs at the Annual Meetings of the Society for Neuroscience in November and the American Society of Hematology (ASH) in early December."
Presentations at the ESGCT Meeting
Saturday, October 26
Sunday, October 27
Monday, October 28
Summary of Clinical Trial Design
About SB-728-902 Cohort 5
Ten HIV-infected subjects heterozygous for the CCR5 delta-32 mutation (i.e. with one CCR5 gene that is naturally modified) who are currently on ART have been enrolled and have received a single intravenous infusion of SB-728-T (5 to 30 billion modified cells). Two months after SB-728-T treatment, subjects undergo a 16 week TI during which time their ART is discontinued. ART is reinstituted in subjects whose CD4 T-cell counts drop to <350 cells/ mm3 and/or whose HIV-RNA increases to >100,000 /mL for three consecutive weekly measurements. At the end of the TI, subjects with a sustained detectable HIV viral load are reinstituted on ART. Subjects with an undetectable viral load can remain off ART until HIV RNA levels are detectable or their CD4 T-cell count drops below 350 cell/mm3 for three consecutive weekly measurements.
A total of ten subjects have been treated in this cohort.
Of the six evaluable subjects, we observed two subjects in which their VL became undetectable during TI from ART:
In three subjects, there was no reduction in VL during the TI, one completed the TI and in two the TI was terminated early due to their viral loads exceeding the upper limit allowed in the protocol. A seventh subject has not completed TI and is still being evaluated.
About SB-728-902 Cohorts 1-3
The study is an open-label Phase 1 clinical trial to evaluate the safety and tolerability of single infusions of an escalating dose of an autologous (a patient's own) CD4+ T-cell product genetically modified at the CCR5 gene by CCR5-specific ZFNs (SB-728-T). The trial enrolled nine HIV-infected subjects (three cohorts of three subjects each) who have sub-optimal T-cell levels and no detectable viral load on long-term ART. Subjects remained on their existing antiviral therapy while receiving treatment with SB-728-T.
About SB-728-T
Sangamo's drug, SB-728-T, is generated by ZFN-mediated modification of the gene encoding the CCR5 receptor in a patient's own T-cells. ZFN modification disrupts the expression of this key co-receptor for HIV entry and renders cells resistant to HIV infection. The approach is based on the observation that a naturally occurring mutation in the CCR5 gene, CCR5 delta-32, provides protection from HIV infection. Individuals in whom both copies of the CCR5 gene carry the delta-32 mutation are generally not susceptible to the most common strain of HIV.
About Sangamo
Sangamo BioSciences, Inc. is focused on research and development of novel DNA-binding proteins for therapeutic gene regulation and genome editing. The Company has ongoing Phase 2 and Phase1/2 clinical trials to evaluate the safety and efficacy of a novel ZFP Therapeutic® for the treatment of HIV/AIDS. As part of its acquisition of Ceregene Inc., Sangamo acquired a fully-enrolled and funded, double-blind, placebo-controlled Phase 2 trial to evaluate NGF-AAV (CERE-110) in Alzheimer's disease. Sangamo's other therapeutic programs are focused on monogenic diseases, including hemophilia, Huntington's disease and hemoglobinopathies such as beta-thalassemia and sickle cell anemia. Sangamo's core competencies enable the engineering of a class of DNA-binding proteins known as zinc finger DNA-binding proteins (ZFPs). Engineering of ZFPs that recognize a specific DNA sequence enables the creation of sequence-specific ZFP Nucleases (ZFNs) for gene modification and ZFP transcription factors (ZFP TFs) that can control gene expression and, consequently, cell function. Sangamo has entered into a strategic collaboration with Shire AG to develop therapeutics for hemophilia, Huntington's disease and other monogenic diseases and has established strategic partnerships with companies in non-therapeutic applications of its technology including Dow AgroSciences and Sigma-Aldrich Corporation. For more information about Sangamo, visit the company's website at www.sangamo.com.
ZFP Therapeutic® is a registered trademark of Sangamo BioSciences, Inc.
This press release may contain forward-looking statements based on Sangamo's current expectations. These forward-looking statements include, without limitation, references relating to research and development of novel ZFP TFs and ZFNs and therapeutic applications of Sangamo's ZFP technology platform for the treatment of HIV/AIDS, including a potential functional cure for HIV/AIDS, the ability of a ZFP Therapeutic to control HIV infection, projected timing of release of SB-728-T clinical data, the expansion of clinical studies for HIV-infected individuals and the initiation of additional preclinical studies of ZFN-gene modification. Actual results may differ materially from these forward-looking statements due to a number of factors, including uncertainties relating to the initiation and completion of stages of our clinical trials, whether the clinical trials will validate and support the tolerability and efficacy of ZFNs, technological challenges, Sangamo's ability to develop commercially viable products and technological developments by our competitors. For a more detailed discussion of these and other risks, please see Sangamo's public filings with the Securities and Exchange Commission, including the risk factors described in its Annual Report on Form 10-K and its most recent Quarterly Report on Form 10-Q. Sangamo assumes no obligation to update the forward-looking information contained in this press release.
©2012 PR Newswire. All Rights Reserved.
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He's Not Handsome OR Popular, So You Should Vote For Him
He's not just another attractive, likeable Washington insider.
He's not just another attractive, likeable Washington insider.
Good game, good game, good game, good game.
College just got a little less Breaking Bad and a little more Fight Club.
Skinnier than a whale butt yet more toned than a dolphin's.
Oh and are we also supposed to just say yes to drugs now too? Because someone tells us to? Yeah okay I'll click true.
Oh hey there. You're still up? I bet you have tons you should be doing right now, huh? You should take a look at these gifs if only for a minute. They'll be super quick. They're over in just a second …
He's a real human being, and a real hero.
They both got their masters in Psychology but he got Valedic-DOG-ian.
It's the wonderful time of the year again. The flowers are blooming, the weather is warm, and dammit, fuck, shit you haven't slept in three days and if you read one more piece of information you're go …

subset: commoncrawl


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This British babe, affectionately known as R.Pattz, plays guitar and piano and wanted to become a musician like older sister Lizzy. His father steered him toward acting and after a chance meeting with theater students from England's renowned Harrodian School, he decided to pursue that path. He made his debut at 17 in a TV film called Ring of The Nibelungs. Reese Witherspoon, who played his lover in 2011's Water For Elephants, first played his mother in Vanity Fair (2004). He starred in not one but two of the highest-grossing franchises of all time — Harry Potter (as doomed Cedric Diggory) and the Twilight Saga. It was his portrayal of Bella's beloved bloodsucker Edward Cullen in the five-film Twilight series that made his tousled tresses (which he jokingly credits for 75% of his performance) and brooding stare known around the world despite diehard fans of the books initially opposing his casting. He hasn't given up his musical aspirations entirely as songs by him appear in Twilight and How To Be. In a case of life imitating art, Pattinson started dating his leading lady Kristen Stewart. In the summer of 2012, an infidelity scandal eclipsed coverage of his critically acclaimed role in David Cronenberg's Cosmopolis. Stewart cheated on him with the married director of Snow White and the Huntsman, Rupert Sanders, and eventually issued a public apology. It appears he's forgiven her as the couple was back on (and cohabitating) in time to promote Breaking Dawn Part 2.
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Student Received Award from Community Foundation
Thursday, August 25, 2011
Westminster College first-year student John Jones recently received a scholarship through The Community Foundation of Westmoreland County (CFWC). The funds will be applied to his tuition for the 2011-2012 academic year.
Jones received a $1,000 award from the Brandon Boyd Memorial Scholarship Fund. Jones, a criminal justice studies major, is a son of Kimberly Jones of Ligonier and a graduate of Ligonier Valley High School.
"We are grateful to The Community Foundation of Westmoreland County and their scholarship funds for their support of bright, motivated students, who represent the future of our region," said Gloria Cagigas, Westminster's vice president for institutional advancement.
Since its inception in 1995, CFWC has grown to include over 350 funds valued at $17 million and has granted over $10 million to local non-profit organizations.
In July 2010, CFWC made community foundation history by merging with The Pittsburgh Foundation. The merger of these two organizations signified a new era in non-profit alignment and growth of mission. By harnessing the strength of The Pittsburgh Foundation, CFWC has an increased presence across the region, offering its donors improved services, increased grant-making opportunities to its non-profit partners, and service to Westmoreland County at a greater level.


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Twitter: @RealJohnSears
Manti Te'o had one of the greatest seasons of any middle linebacker in college football history. He led the best defense in the country to the BCS National Championship game with many memorable wins along the way. It's safe to say, however, that anyone who would interview him now wouldn't be interested in talking about his stellar season.
When Deadspin.com reported on Wednesday that Manti Te'o's girlfriend (who had supposedly died earlier this season) had not died and in fact never existed, the sports world exploded. Even folks on Twitter, where the statute of limitations for any story is maybe a few hours, are still buzzing about it some 48 hours later.
It has been, by far, the most bizarre story I have ever followed.
In the coming days and weeks ahead we will find more information regarding this ordeal. We already know a ton. But in a way we really don't know much. That should really give you a sense of the magnitude and far reaching impact of it.
In the initial report by Deadspin.com, it was clear that Manti Te'o was being portrayed as a complicit partner in the hoax, ran by Ronaiah Tuiasosopo who was a known acquaintance (at the very least) of Manti. The article quoted a source as saying, that they were "80 percent sure" Manti Te'o was "in on it". The source also went on to say they made it up in order for Manti to benefit from the publicity.
After that article was published, Notre Dame quickly released a statement in response to it saying that they had known about the "hoax" since December 26th. In a press conference later that evening, Notre Dame athletic director, Jack Swarbick maintained that Te'o had maintained and exclusively online relationship with the fake Lennay Kekua, had been duped throughout the entire process, and did not become aware of the hoax until he received a phone call on December 6th from what was believed to be Kekua's number with a familiar voice on the other end. When asked about specific matters of the situation, Swarbick repeatedly said he would let Manti answer those questions "soon".
If Notre Dame's history tells you anything, it's that you shouldn't take their word as gospel. They have a history of embellishments and cover ups; whether it's a coach faking that his son has cancer so his team will win or covering up rapes involving football players or covering up a fake girlfriend so it doesn't distract their team or start player from playing in the National Championship. Yeah, that worked out well…
At this point, one thing is for certain: Manti Te'o is a liar. To what extent and for what purpose, we still do not know.
We know Manti Te'o lied about ever meeting her. The South Bend Tribune: "Their stares got pleasantly tangled, then Manti Te'o extended his hand to the stranger with a warm smile and soulful eyes." This was in regards to their first meeting after the Stanford/Notre Dame game in November of 2009. It was confirmed by Te'o.
We know Brian Te'o, Manti's father, lied about the two hanging out in Hawaii from 2010-2011. He was quoted as saying, "Every once in a while, she would travel to Hawaii, and that happened to be the time Manti was home, so he would meet with her there."
We don't know, however, if Manti Te'o was involved in the hoax from the beginning, whether he knew part of the way through, or whether he never knew at all.
According to ESPN, Manti Te'o and Kekua began to talk nightly in early 2012 until Kekua was in a serious car crash in April of 2012. Doctors then discovered that the fake girl had cancer and treated her. She then starts to get better throughout the summer and is eventually released from the hospital on September 10th, 2012 according the South Bend Tribune.
This is where the story starts to get weird (as if it wasn't already). On September 10-11th Manti Te'o's real grandmother dies after a long illness. What is weird is that his girlfriend dies within this same timespan even after she was released from the hospital after her condition improved. Multiple media outlets reported that she had died on five different dates.
I think it's kind of a coincidence that the hoaxers knew that Manti's grandmother had died and conveniently killed off Kekua right after…or before…what was it? Or could it have been that Manti decided with Ronaiah to kill off Kekua in the midst of his grandmother's passing in order to magnify the situation?
Te'o then goes out the same week and has a great game against Michigan State in both their honors.
There is no doubt that this whole saga raises hundreds of questions.
Why lie about meeting her multiple times? Why did he never visit her, in the summer while there was no school and he was presumably free, while she had been in the hospital after a "serious" car accident and while she was fighting leukemia? Finally, why did he never visit her grave or her family after she had died? If she was truly "love of his life" as he said, these are surely things he should've felt compelled to do.
Earlier today Shelley Smith of ESPN reported a story in which she quotes two people who claim that Ronaiah Tuiasosopo pulled a similar hoax on their cousin a few years ago. "I found out his (Manti Te'o) girlfriend's name was Lennay Kekua. And right when I read the name Lennay Kekua, I immediately thought of Ronaiah. Then I thought of my cousin — that this has to be the same person" said one of them. Smith then quoted anonymous source who said she was friends with Ronaiah, "He (Ronaiah) told me that Manti was not involved at all, he was a victim. … The girlfriend was a lie, the accident was a lie, the leukemia was a lie".
However, why should we believe ESPN, who couldn't (with all their might) get the story out before Deadspin? Why should we believe a secondhand confession through an anonymous source from a compulsive liar? The only person who could have performed this elaborate hoax, which Ronaiah has "confessed" doing, would have to be a compulsive liar. I'm sorry, but I'm going to need more than that to believe Manti or Notre Dame on this one.
We know Manti was friends with Ronaiah and we know Ronaiah was probably behind the fake girl. But why would he attempt to fool his friend? Jack Swarbick believed it was to humiliate Manti. But wouldn't the best way to humiliate him be to use the Twitter account that was created for Kekua as a way to publicize it? Calling him on the phone hardly seems like humiliation since only Manti would know about it.
In the past two days teammates have been quoted as saying that they had suspicions about Te'o's mystery girlfriend. One in particular said "He lied, but the media blew it up" and that Te'o was a "very good" actor. Then there is this video where you can see Te'o's teammates snickering Brian Kelly brings up Manti's struggles and as Manti speaks about his fake dead girlfriend.
Alema Te'o, Manti's uncle, spoke with 1280 The Zone in Chicago yesterday saying, "Ronaiah Tuiasosopo is a liar, he concocted the whole thing, he misrepresented whatever program that he was trying to get across to Manti, and shoot, he lied every step of the way. I don't feel it's beyond him to hire somebody or bring somebody in to play the role of Lennay to get Manti to buy into this deal." He then went on to describe a situation where he walked in on Manti talking to Ronaiah. About what, he did not know.
Gene Wojciechowski of ESPN interviewed Te'o about losing the two women back in October. He said in researching for preparation that he found no obituary or record of a car accident for Lennay Kekua. "We asked Manti, could we contact Lennay's family and he said the family would prefer not to be contacted. Could we have some photos of Lennay? He said the family would prefer not to provide those" said Wojciechowski.
Kind of suspicious, don't you think? Considering Lennay's family didn't exist.
Even further evidence shows part of an interview where Manti says that his girlfriend wrote him letters before every game. He said the last one she wrote was before the Stanford game this season. Problem is, she was reported dead 31 days prior to that game.
Here we come to the part where Te'o continued to speak about his fake dead girlfriend even after he found out that she was in fact not dead, according to Notre Dame. His quotes can be seen here. Why did he continually bring her up even though he knew about the hoax? He could have easily dodged any of those questions by simply talking about how he was thankful for his teammates and coaches. He didn't have to refer to her directly, but he did. This makes him a liar. Whether out of embarrassment or whether he was perpetuating the lie on purpose; he is a liar.
Just under three days after the news broke, Te'o finally broke his silence on the matter. In an off camera interview with his lawyer present, Te'o denied being involved in the hoax at any point and maintained his innocence throughout. He did however admit to lying to his father and the media about the extent of his relationship with the fake girl. He also said that Ronaiah Tuiasosopo confessed to him via Twitter that he was the one behind it along with two more unnamed people. However as Deadspin points out, "Schaap said he saw the messages, but we're still not sure how such an apology would have worked. Tuiasosopo deleted his Twitter account weeks ago, and direct messages on Twitter require the recipient to follow the sender. We checked the list of Twitter users Te'o follows on Tuesday and didn't see any sign of Ronaiah."
But why finally do an interview late on a Friday night, off camera, and with your lawyer present if you have nothing to hide? His story still does not even mesh with that of Notre Dame's. He says he wasn't convinced that Kekua wasn't real until two days ago. It's strange though that on December 26th, he notified Notre Dame of his suspicions. Notre Dame then shared the findings of their investigation with the Te'o on January 5th. But somehow he wasn't convinced till two days ago? I'm not going to buy that.
We may never know the whole truth about this scandal. Manti Te'o probably will never own up to concocting this plan; whether because he didn't, or because he doesn't want people to know he did. His family, agents, and Notre Dame will probably attempt to "leak" things out to make him seem innocent.
But one thing is for certain. I will never trust what Notre Dame or Te'o have to say again. Their history dictates probable cause.


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REGINALD BRETT (LATER 2nd VISCOUNT ESHER) |
Peter Ewart
Interesting. As far as I know, on 11th Feb they only had Lord C's despatch (via ship then telegraph) to go on, did they not, plus any premature comment accompanying the news in The Times or Telegraph of that morning? His access to those in government circles brought links only with speculation, surely? Lord C had not yet gone into quite so much detail, at least as far as the cause or any culpability (including his). Haven't time to look now but was the loss of the Colour mentioned so early, i.e. in Lord C's bald original despatch? I hadn't thought so. The myths about the Colour's recovery are not that surprising as the rumours were already about, and even military tradition pointed to that as a possibility. The papers - Times, Telegraph (which I haven't seen) & Guardian (not the M/C G'n) were full of such rumours, speculation, innuendo & debate on the causes and the culpability by that time, as was Hansard & society generally. One row over the Duke and Lord C went on for weeks. I have my doubts as to whether his 11 Jan (sorry, Feb!)entry was actually made on that day. Peter |
Last edited by Peter Ewart on Tue Dec 06, 2011 10:35 pm; edited 1 time in total |
Other journal entries for February 8th and 14th are also quoted though contain no material of specific interest to us here, both whilst in London, and there will most probably be others in the gaps that were not thought of sufficient interest by the compiler.
I would therefore think that a February 11th journal entry is accurately dated, remembering that only in the March 4th entry do we find reference to a Chelmsford despatch as having arrived. The rest of his entry for that date is pretty much clubland stuff, and it's the reference to essentially factually accurate stuff on 11th February that is the more interesting one I feel. It is just possible that Hartington was extended some sort of privileged information under Privy Council terms. Brett sometimes catches up on the weekend events in his journal early the next week, but only if very occupied socially. Generally his diary entries are diligent and regular. G |
Keith Smith
Chelmsford's famous telegram is dated Pietermaritzburg, 27 January 1879, and was introduced by Sir Bartle Frere: 'Lord Chelmsford wishes the following to be sent to the Right Honourable the Secretary of State for War'. According to the printed version, it was received in London on 15 February (BPP C. 2262, p. 33f. No. 14: Frere to Hicks Beach).
A copy is also in TNA WO 32/7706, in which it is headed 'Telegram (dated St Vincent 10th 6-40 p.m.) (Received Colonial Office 10th midnight). One must wonder what happened between the 11th and 15th February, apart from Brett's reading it almost immediately after it was received. KIS |
Peter Ewart
Gallo & Keith
The news was definitely out on the 12th Feb, if not the 11th. (Those with ready access to the right people on the 11th, the newspapers on the 12th at latest). Look at Dawnay's account of his hearing the news when he came down to breakfast in Yorkshire on Wed 12th - assuming his memory or his diary was accurate. (Of course, his family, too, was hardly without excellent connections, so it is not impossible he heard earlier than the general public, but I think this unlikely. He journeyed to London & back and, like others, was by the 15th hurriedly making plans to get out to SA. (Dawnay, p1). But Lord C mentioned nothing about lost Colours. (Just checked). Did Frere's covering letter do so? If it didn't, then no-one in England yet knew of any lost Colour, surely? If Frere didn't mention the Colour, Brett's diary entry must have been entered retrospectively. Or have I missed something? Anyone got Frere's full note to hand? Peter |
Paul Bryant-Quinn
News about Isandlwana may have reached Britain on Tuesday 11th; unless I am mistaken, Chelmsfords despatch was from St. Vincent, February 10, 6.40 p.m. (I regret to have to report a very disastrous engagement ...). The following is taken from the North Wales Express on 14.2.'79, and is obviously lifted from another newspaper:
Peter Ewart
Just to clarify:
Lord C's despatch didn't mention the loss of any Colours but Brett appears aware of the loss on the 11th, only hours after the receipt. As he is aware of the loss of everything in the camp ("2 guns, 2 rocket tubes" ..."supplies, ammunition & transport") it may be he was assuming the Colour was in the camp and lost. A strange assumption, or not? But if his entry was entered retrospectively - not unknown in journals - then he could have been aware. But not with any certainty whatsoever on the 11th Feb, any more than he can have had any idea of the "great carelessness" he mentions, although he might have inferred this from Lord C's "It would seem that the troops were enticed away from their camp, as the action took place about one mile and a quarter outside it..." I'm not really surprised that he knew of the disaster so quickly. It would have spread like wildfire among certain London circles, even outside the immediate government or WO departments. He only had to be in touch with momentarily - or even bump into - any single one of his contacts who had just heard the news at any time from the early hours onwards. His "great carelessness" remark might simply have reflected the immediate gossip, as also might the presumed loss of the Colour. But unless Frere had mentioned it (was there a covering note, Keith, or just that introductory sentence?) then he couldn't have known for certain. I'm also assuming that the other despatch sent by Lord C on 27th, and referred to in the one above, went entirely by sea or, if also telegraphed from St Vincent, went by a later boat. I know I can lay my hands on the dates of all the despatches and dates of receipt somewhere here, but don't have time at the moment. Gallo, is your main query the actual access Brett had to the info so quickly, while out of government? Or his views at such an early time? Peter |
Peter Ewart
I see we were posting almost sumultaneously. Your piece confirms that all & sundry (in certain circles) in London were aware during the 11th - it would almost be surprising if Brett had not been aware. If Brett's entry of the 11th was entered on that day, I'd take it that he was already recording rumours emanating from gossip & assumptions, especially about the Colour. Peter |
Paul Bryant-Quinn
Plus, of course, back then people could both post letters and receive replies on the same day. Not to mention the wonderful "electric telegraph" ...
Keith Smith
An apology, gentlemen. In error, I earlier quoted Chelmsford's telegram as appearing in the Parliamentary Paper C. 2262. It should, of course, be C. 2242. Frere's contribution was just one sentence: 'Lord Chelmsford wishes the following to be sent to the Right Honourable the Secretary of State for War'.
Chelmsford's written report was dated 14 January but again did not mention the loss of the Colours. (BPP C. 2242, Enclosure 8 in No. 20, p. 46ff.) KIS |
Paul Bryant-Quinn
And my apologies to you, Keith: I note that you had already given the date and time of the St Vincent despatch prior to my post.
This does lead us on to the possibility that Lord Chelmsford reporting back to the War Department was possibly not the only reporting stream from South Africa, with the Colonial Office and the India Office being other possible information paths. I was once told by an old FCO hand in the 1960s that the India Office had still maintained a small civil liaison staff at the Cape until well into the 1890s, even after the Suez Canal opened, so as to address issue affecting the two-way mercantile trade and the Indian Merchant Navy. Also, and as force generation for the Army Corps in 1899 indicated, there were still reinforcement options for the Indian Army along the East coast of Africa and some of the Atlantic territories.
It does though beg the interesting question of exactly how these messages were passed - by whom, by what routing, by what time waypoints - and at what stage they were encrypted for telegraphic transmission. As did Lord Roberts in the contemporary Afghanistan campaign, Lord Chelmsford would also very probably have had a Royal Engineer 'Confidential Clerk' somewhere in his South African Field Force command and staff structure whose duties included ensuring that encoded traffic was properly formatted prior to onwards transmission. Actual encoding might have been done in the same way, but was usually a shared responsibility with a designated officer. Higher level traffic would usually be encoded twice whenever it was sufficiewntly highly classified material not to be seen by anybody other than a small list of authorised persons. G |
Peter Ewart
Yes, it would be easy to fall into the trap of assuming the only messages - letters, telegrams, reports etc - which can tell us anything important are those which we already know about, but of course any number of well placed officers or civilans in Natal & Zululand would have written home to family, friends and confidants - although none had the opportunity to beat Lord C with the first message - and some of these may yet, even now, come out of the woodwork. Even if they don't, they may well have informed certain opinions, rumours or gossip of the time. Lord C's tortuous route back to PMB meant his initial despatch was delayed until the 27th. Undoubtedly other (private) letters soon followed from Natal, and within a week or two, when conditions permitted, from Zululand, as we all know. But presumably very few, if any, made part of their journey by telegaph, other than Lord C's. Presumably his Staff, if writing home privately, kept their counsel, or at least stuck to the "party line" But who else in PMB, for example, might have confided in all sorts of contacts in GB? Frere? Lady Frere? The latter certainly did. But, again, it would have been some days, at least, before anyone could have got a message from SA to GB faster then the General. Just Frere, his staff & Lady Frere, I suppose. Then there were the newspapers! Those in Natal & GB all carried unattributed reports, claims, stories & rumours, constantly mixed in with the "factual" reports, invariably from "an officer in the field" or "one whose word can be relied upon" as they always put it. They certainly succeeded in muddying the water. Members in the Lords and Commons were also fed this stuff privately, as the debates demonstrate. I'd be intrigued to know which letter had arrived in London by 11th Feb and mentioned the loss of the Colour, but I suppose it is of little import overall, other than raising a slight question mark over Brett's journal entries. Peter |
Well versed as I am in the notion of an "inconvenient fact" there is no particular reason to assume that the Brett February 11th journal entry is erroneous, by content or date, though the two volume edition of his "Journals & Letters" correspondence and journals is by its very nature a secondary source and an independent check of the primary source would obviously create greater assurance. The Esher Papers are held in one of the Oxbridge Colleges if anybody is feeling very keen.
It does behove us to think through the nuts and bolts of how information was communicated rearwards from Natal and the Cape since it would at least let us appreciate the various lead-lag effects of official and media treatments of the two way flow of information. Interesting though that the idea of replacing Lord Chelmsford was receiving Prime Ministerial and Cabinet level consideration so early. And Brett's view on the likely effects of criticising Chelmsford. The extracts do not feature any further mentions of the Zulu War and also make only passing mention of the 1880-81 Boer War whilst making frequent references to various forms of social tittle tattle. From a historical viewpoint its not a very useful compilation even when dealing with Esher's later role in various early 20th century committees. But the source pieces might still deliver up a few nuggets. G |
For 'keenies' only, I fear, and a dead end by itself:
http://janus.lib.cam.ac.uk/db/node.xsp?I'd=EAD%2FGBR%2F0014%2FESHR G |
REGINALD BRETT (LATER 2nd VISCOUNT ESHER) |
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Category Archives: Development
Sat, Dec 07, 2013 | 17:03 GMT
Broken Age's lumberjack Curtis to be voiced by Wil Wheaton
Broken Age, in development at Double Fine, has a new video revealing the latest addition to the voice cast: Wil Wheaton. He will be lending his chops to the lumberjack Curtis. Watch the video below. Broken Age will be released in two parts, starting in January. Thanks, Blue.
Fri, Dec 06, 2013 | 20:45 GMT
Project Ascender in the works for PC, PS4 from Duke Nukem creator and Rise of the Triad developer
Project Ascender is in development for PS4 and PC, and it's from Duke Nukem creator and co-founder of 3D Realms, Scott Miller and Rise of the Triad developer Interceptor Entertainment. The project was spotted on Interceptor CEO Frederik Schreiber's LinkedIn profile. The game has apparently been in development since September and has 19 staffer members working on it. The game is due in 2014. Thanks, Eurogamer.
Fri, Dec 06, 2013 | 20:39 GMT
EverQuest Next Landmark video released
SOE has released a new video for EverQyest Landmark. It basically gives you the rundown on what the game encompasses. Watch it below. You can still sign up for alpha access through here. Thanks, Erthazus.
Fri, Dec 06, 2013 | 19:44 GMT
Samurai Warriors 4 gameplay trailer released
Samurai Warriors 4, which is due in for release March 20 on PlayStation 3 and Vita, has a gameplay trailer available. The game will allow players to switch characters, similar to Samurai Warrriors: Chronicles on the Nintendo 3DS. Check out the video below. Thanks, Siliconera.
Fri, Dec 06, 2013 | 16:11 GMT
The Wolf Among Us: Episode 2 – Smoke & Mirrors introduces Fables staple Jack
The Wolf Among Us has a couple new screenshots available, showing off Episode 2: Smoke & Mirrors.
Sat, Dec 07, 2013 | 19:47 GMT
Visceral Games working on military shooter, possible brand extension of Battlefield – Pachter
Wedbush Morgan analyst Michael Pachter has told Eurogamer it is Dead Space developer Visceral Games making the shooter he was alluding to earlier this morning.
Fri, Dec 06, 2013 | 14:22 GMT
Bohemia Interactive announces €500,000 Make Arma Not War content creation contest for Arma 3
Bohemia Interactive has announced a €500,000 Make Arma Not War content creation contest for Arma 3. Cash prizes range from €20,000 to €200,000, and are spread across four different categories: Total Modification, Singleplayer Game Mode, Multiplayer Game Mode, and Addon.
Fri, Dec 06, 2013 | 00:06 GMT
Bayonetta creator 'doesn't really get a chance' to do sequels
Bayonetta creator Hideki Kamiya isn't in direct charge of the upcoming sequel, and not entirely by choice.
Thu, Dec 05, 2013 | 20:37 GMT
Microsoft has shuttered its Victoria studio in Canada
Microsoft has shuttered its Victoria studio in Canada, leaving 30 people out of work, according to Times Colonist, via Superannuation.
Thu, Dec 05, 2013 | 21:30 GMT
Battlefield 4 one-hit-kill bug update out for PS4, PS3 update rolls out in Europe
DICE is rolling out a Battlefield 4 update for PS4 which aims to fix the one-hit kill bug. The PS3 versions is also getting an extensive update in Europe. Players may get booted from ongoing games before they can reconnect to the new server versions.
Wed, Dec 04, 2013 | 15:09 GMT
Unreal Engine 4: second Inside Unreal video takes a look at VFX in the Infiltrator real-time demo
Epic has released a new video in its Inside Unreal series, and its part two of the firm's VFX in the Infiltrator Demo for Unreal Engine 4.
Thu, Dec 05, 2013 | 08:34 GMT
ID@Xbox: Microsoft signs 32 developers – includes Comcept, Double Fine, Slightly Mad
Microsoft has revealed a list of developers which are part of Xbox One's indie development program ID@Xbox. The firm has also dropped its "requirement" that the games remain exclusive or timed-exclusives to Xbox One.
Tue, Dec 03, 2013 | 16:55 GMT
Survarium closed beta starting in "a week or two," scheduled for launch during second half of 2014
Survarium, the free-to-play PC MMOFPS from Vostok Games will transition into closed beta "within a week or two," the firm has told Eurogamer. Invites will be sent out to the international community at that time, and you can sign up for the tester here. The game will launch in the UK during the second half of 2014. You can watch the latest developer diary here.
Tue, Dec 03, 2013 | 15:43 GMT
Rainbow Moon releases for PS Vita today in North America, tomorrow in Europe
Rainbow Moon, the dungeon crawler RPG from SideQuest Studios and the eastasiasoft team, is out today for PS Vita in North America.
Tue, Dec 03, 2013 | 15:33 GMT
WildStar's Medic and Engineer classes revealed
WildStar developers Carbine Studios have revealed the final two classes for the MMO: the Medic and Engineer.
Tue, Dec 03, 2013 | 15:11 GMT
Lightning Returns: Final Fantasy 13 – Inside The Square part 2 goes behind-the-scenes
Lightning Returns: Final Fantasy 13 has a second developer video available in which the team behind the game provides insights into the creation of the game. Part three will be released at a later date, and you can watch part one again here.
Thu, Nov 28, 2013 | 05:46 GMT
Shenmue 3 trademark proves to be a hoax, OHIM also discards Fallout 4 trademark application
The Shenmue 3 trademark which popped up this week has turned out to be a hoax, according to CVG. The application was filed with the Office of Harmonization for the Internal Market (OHIM), and after being examined by officials it was discarded. The OHIM discarded the Fallout 4 trademark filed last week, as it did with the Half-Life 3 application in October.
Tue, Nov 26, 2013 | 21:14 GMT
Yu Suzuki to provide Shenmue postmortem talk during GDC 2014
Yu Suzuki will provide a Classic Game Postmortem on his Dreamcast game Shenmue during GDC 2014. The talk will be translated by Mark Cerny, who you know as the game designer of Knack and lead system architect for PlayStation 4. This will be Suzuki's first time discussing the creation Shenmue at an event, GDC organizers said. The talk will start from the game'sorigin as a Virtua Fighter-based RPG on Sega Saturn, leading up to the game's release on Dreamcast in 1999. GDC 2014 takes place March 17-21.
Tue, Nov 26, 2013 | 20:19 GMT
Uncharted 4 teased via mo-cap pictures posted by Todd Stashwick on Twitter
Uncharted 4 has been teased on Twitter by Todd Stashwick, the voice you hear in the teaser trailer released earlier this month. All Stashwick has teased are motion capture photos of himself and a dummy. You can view those through his feed. The PlayStation 4 title is being written once again by creative director Amy Hennig and Uncharted 3: Drake's Deception's director, Justin Richmond is working on it as well. Drake actor Nolan North has been unusually quiet regarding the project, but we expect to possibly hear more about the game during VGX next month. Thanks, IGN.


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During this week's Accelerator session, Mark Fenwick drew on his extensive commercial experience as he demonstrated how to grow your organisation. His presentation of big questions to the whole group was balanced with valuable opportunities for small group discussions, where everyone could focus on what growth meant for them. And specifically what changes they would need to implement to make this happen.
Initially, a group exercise identified that all organisations are different, for example the number of staff doesn't necessarily relate to turnover, or that being an older organisation doesn't have to mean that you have more influence. This showed that all organisations have different aspects of their business that they want to grow. Mark emphasised that the key point is to identify exactly what it is that you want to grow, then think about what needs to change to create that growth. He urged everyone to remember that growth is all about change, and that it is impossible to grow by staying the same. more >


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SOUTH CHARLESTON, W.Va. (AP) — West Virginia hunters began seeking wild boar on Saturday.
The season runs through Nov. 2 and is restricted to Boone, Logan, Raleigh and Wyoming counties.
The dates were announced by the West Virginia Division of Natural Resources.
The boar harvest has decreased since the record high of 158 in 1995. Because of declining boar numbers, gun hunters are restricted to an October firearms season. Wild boar archery season has been underway since Oct. 12 and will run through Dec. 31.
Boar season open in W.Va.
- Outdoors
Time flies
There must be some sort of Gregorian mechanism I don't understand that makes calendar time go by faster from Sept. 6 through early December.
Hunter, 90, bags buck
I had the pleasure of meeting you about four years ago during a banquet for the Allegany/Garrett Sportsmen's Association. I was that year's recipient of their annual scholarship.
- Happy hunter
Pa. bear numbers reported
Hunters killed 2,308 bears during the recent Pennsylvania season, according to the Pennsylvania Game Commission.
Safari Club winner's bear killed illegally in Alaska
A Michigan woman who received a prestigious award from an international hunting organization for killing a grizzly bear in the Arctic National Wildlife Refuge four years ago was sentenced in federal court in Fairbanks recently for illegally killing the bear.
Three bears recently shot
The number of bears to have perished on Maryland roadways in 2013 rose slightly to 39, according to an unofficial count maintained by the Cumberland Times-News.
Quota met for Kentucky bear bow hunters
Hunters met the quota of 10 bears during Kentucky's inaugural archery/crossbow season for black bears, which recently ended.
Times-News will use deer photos
The Cumberland Times-News will use photographs of hunters with deer that they harvested during the 2013 seasons. There is no charge.
Venison main course
I have an unscientific observation for
What's new, right? -
Go online for W.Va. hunt/fish info
The expression "information at the
touch of a button" could have been
coined for the newest feature on
the Division of Natural Resources'
website. - More Outdoors Headlines
Time flies


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The judge in a Connecticut criminal case is allowing an animated video re-creating a car crash to be used in trial, despite defense arguments describing it as a "Disney World-created fantasy tape" that would distort the truth.
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Conn. Criminal Court to Allow Video Re-Creation of Car Crash
The Connecticut Law Tribune
October 11, 2012
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Comment: From the "burning" AMD Athlons (Score 1) 259
Tom's got nailed over the "burning" AMD Athlons. If you dig through the HardOCP forums from back in 2001-2002, Kyle Bennett and others managed to trace some not so savory relationships with Intel and the site.
I've never trusted Tom's since and they have a well established Intel bias. HardOCP is much more transparent in it's testng.


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We've got all of the cute and colorful looks from the first collection.
The collection consists of graphic tees, hoodies, and sweats, and the price point is killer — the goods don't exceed the $17 mark. Take a look at the brand's very first lookbook, and keep your eyes peeled for Hard Candy clothing at a store near you come December.


text: 2009 Chevrolet Corvette Z06 2009 Chevy CorvetteBy Ray Wert PO Edit123L 2009 Competition Sport Corvette Priced At $55,655 For 1LT, $77,500 For …Jalopnik sources tell us pricing on the 2009 Corvette Competition Sport's now official. The Z51-equipped 1LT will run $55,655 and the Z06 model will cost you $77,500 including charges. Read… 1/27/09 10:30am 1/27/09 10:30am2009 Competition Sport Corvette: At Least Look Like You Belong On The Track


text:
DHAKA: Women who reach menopause before the age of 46 are twice as likely to have a heart attack or stroke as compared women who go through the change later in life, a new study has revealed. The findings from a diverse group of U.S. women supports results of earlier studies, which had focused only on white women.Early menopause was found to double the risk of stroke and heart attack. Lead author Dr Melissa Wellons, from the University of Alabama at Birmingham, said that women who experienced early menopause should make extra efforts to reduce their risk."My advice to them would be to get your traditional risk factors checked and do the things that we know, based on evidence, can improve your risk of developing heart disease, like keep your cholesterol in check and keep your blood pressure in check," a daily quoted her as saying.Wellons and her colleagues collected health information through surveys of 2,509 women, including 331 Chinese, 641 black and 550 Hispanic women.Close to 700 of them, or 28 per cent, had undergone menopause early - before age 46. The average age when women stop having periods is 51 in the U.S and 52 in the UK.The younger group included women who went through menopause naturally or had a hysterectomy - surgery to remove the uterus - that can cause early menopause.None of the women in the group had cardiovascular disease at the beginning of the study. Researchers tracked them for an average of five years to see who ended up having a heart attack or stroke.They found that 23 women who had gone through menopause early, and 27 who hadn`t, suffered a heart attack or cardiac arrest or died from heart disease.Similarly, 18 women - or 2.6 per cent - of the early menopause group had a stroke during the study, as compared to 19 (one per cent) of women who hit menopause later.It`s not clear why early menopause might be linked to cardiovascular disease. Some scientists have theorised that estrogen could play a role as the hormone drops following the change.However, a Women`s Health Initiative study on hormone replacement therapy was stopped early because women taking hormones after menopause were actually found to have a higher risk of heart disease and certain cancers."It could be a genetic association, (where) genes that are related to ovarian function may also be associated with cardiovascular disease, and those two things are related but not through a common causal pathway," Dr Wellons added. The findings were published in the journal Menopause.BDST: 1313 HRS, JULY 04, 2012Edited by: Tania Afrin, Newsroom Editor
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text:
Frightening Statistics about Mental Illness
25% of the women in this country are on medication for mental illness.
That's scary. It means 75% are running around untreated.
2 Responses
3 days ago
On a desolate island in the middle of nowhere, the following group of people are shipwrecked :2 Italian men and 1 Italian woman2 French men and 1 French woman2 German men and 1 German woman2 Greek men and 1 Greek woman2 Bulgarian men and 1 Bulgarian woman2 Japanese men and 1...
1 Response
22 hours ago
A man is in a bar and falling off his stool every couple of minutes. He is obviously drunk. So the bartender says to another man in the bar: "Why don't you be a good Samaritan and take him home."The man takes the drunk out the door and to his car and he stumbles at least ten...
10 Responses
3 days ago
Walmart Shopper - After landing my new job as a Walmart greeter, a good find for many retirees, I lasted less than a day ...... About two hours into my first day on the job a very loud, decidedly unattractive, woman walked into the store along with her two kids, yelling...
118 Responses
Sep 23, 2012
Cyber Sex Chat - Online computer users often engage in what is affectionately known as "Cybersex". Often the fantasies typed into keyboards and shared through Internet phone lines get pretty raunchy. However, as you'll see below, one of the two cyber-surfers in the following...
49 Responses
May 5, 2011
The "Jag" - Night and Day
A woman buys a new automatic Jaguar XKR Sport. She drives the car perfectly during the day, but at night, the car just won't move at all. After trying to drive the car at night for a week (but without any luck), she furiously calls the Jaguar dealers...
2 Responses
13 hours ago
Your Prayers were answered A young man, living away from home, writes to his parents:
Dear folks, I feel miserable because I have to keep writing for money. I feel ashamed and unhappy to have to ask for another hundred, but every cell in my body rebels. I beg on bended knee...
1 Response
1 day ago
When Insults Had ClassThese are just too, too funny and admirable in a day when everyone is text messaging in obscure codes and discounting the value of a well-turned phrase!A member of Parliament to Disraeli: "Sir, you will either die on the gallows or of some unspeakable...
4 Responses
2 days ago
How To Lose Weight, For You Guys -
A guy calls a company and orders their 5-day, 10 lb. weight loss program..
The next day, there's a knock on the door and there stands before him a voluptuous,
athletic, 19 year old babe dressed in nothing but a pair...
47 Responses
Sep 16, 2012
How much dub could dubstep step if dubstep could step dub? O_o
1 Response
1 day ago
Rye Bread
Two old guys, one 80 and one 87, were sitting on their usual park bench one morning. The 87 year old had just finished his morning jog and wasn't even short of breath.
The 80 year old was amazed at his friend's stamina and asked him what he did to have so much...
1 Response
16 hours ago
Out in the Car
A man had been drinking at the bar for hours when he mentioned something about his girlfriend being out in the car.
The bartender, concerned because it was so cold, went to check on her. When he looked inside the car, he saw the drunk's buddy, Pete, and the man's...
5 Responses
4 days ago
Dear Dogs And Cats: - The dishes with the paw print are yours and contain your food. The other dishes are mine and contain my food. Please note, placing a paw print in the middle of my plate and food does not stake a claim for it becoming your food and dish, nor do I find that...
23 Responses
Sep 25, 2011
Daily Joke 10-31-2006 - I start with a 'safe' joke about a blonde girl... (he thats me ;-) )
A highway patrolman pulled up alongside a speeding car on the freeway. As the officer peered through the driver's window, he was astounded to find that the blonde behind the wheel was...
36 Responses
Oct 31, 2006
Never Wax Your Hoo-ha - All hair removal methods have tricked women with their promises of easy, painless removal - The Epilady, scissors, razors, Nair and now...the wax. Read on.........
My night began as any other normal weeknight. Come home, fix dinner, play with the kids.
153 Responses
Feb 27
Daily Joke 11-1-2006 - Too Many Buttons
A gentleman had a serious problem. He made several attempts to enter the men's washrooom, but found it to be occupied. A lady noticed that he was walking strangely, taking small steps, and with a look of pain and anxiety on his face...
30 Responses
Nov 1, 2006
a Woman's Ultimate Fantasy - A Woman's Ultimate Fantasy...
In a recent On-line poll 38,562 men across the UK were asked to identify a woman's ultimate fantasy. 98.8% of the respondents said that a woman's ultimate fantasy is to have two men at once.
While this has been...
20 Responses
Nov 18, 2006
A guy walks into a New York bar and orders 3 beers, which he drinks and then leaves. Night after night he does the same thing, until finally the bartender engages him in conversation. He explains, "When my brothers Mike, Paddy, and I left Ireland to go our separate ways, we vowed...
3 Responses
3 days ago
Doctor Romance - A man and woman are at a bar having a few beers. They start talking and soon realize they're both doctors. After an hour, the man says, "Hey, how about if we sleep together tonight? No strings attached." The woman doctor agrees to it. They go back to her place...
37 Responses
Oct 11, 2012
Kids say the darnedest things ~
A handful of 7 year old children were asked what they thought of beer. There were some interesting responses, but the last one is especially touching.
'I think beer must be good. My dad says the more beer he drinks the prettier my mum gets...
3 Responses
2 days ago
Counting... One, Two, Three.... -
Harry is getting along in years and finds that he is unable to perform sexually. He finally goes to his doctor who tries a few things, but nothing seems to work. So the doctor refers him to an American Indian medicine man.
The medicine man...
39 Responses
Jan 20, 2010
A Mature Lady - A mature lady gets pulled over for speeding...
Older Woman: Is there a problem, Officer?
Traffic Cop: Yes ma'am, I'm afraid you were speeding.
Older Woman: Oh, I see.
Traffic Cop: Can I see your license please?
Older Woman: Well, I would give it to you but I...
84 Responses
Sep 28, 2012
Why Men Are Never Depressed -
Men Are Just Happier People --
What do you expect from such simple creatures?
Your last name stays put.
The garage is all yours.
Wedding plans take care of themselves.
Chocolate is just another snack...
33 Responses
Mar 19
I love jokes with a passion, it might take me a while to get it but hopefully i will:)
1 Response
1 day ago
Blonde Joke
A blonde heard that bathing in milk would make her beautiful. She left a note for her milkman to leave 25 gallons of milk. When the milkman read the note, he felt there must be a mistake. He thought she probably meant 2.5 gallons. So he knocked on the door to...
2 Responses
16 hours ago
The Duchess was helping herself to the buffet at her garden party when she broke wind embarrassingly loudly. Clearly wanting to escape blame she turned to her chauffeur who was next in the queue."Stop that, my man." she commanded.To which he replied "Certainly Madam. Which way...
1 Response
4 hours ago
The $2.99 Special
We went to breakfast at a restaurant where the 'seniors' special' was two eggs, bacon, hash browns and toast for $2.99.
'Sounds good,' my wife said. 'But I don't want the eggs..'
'Then, I'll have to charge you $3.49 because you're ordering a la carte,' the...
4 Responses
3 days ago
"why Don't You Please Shut Up??" - "A police officer pulls over a speeding car. The officer says, "I clocked you at 80 miles per hour, sir."The driver says, "Gee, officer I had it on cruise control at 60, perhaps your radar gun needs calibrating."The driver's wife is in the...
62 Responses
Jan 20
Cardiologist's Funeral - This would be an acceptable reason to laugh at a funeral...
A very prestigious cardiologist died, and was given a very elaborate funeral by the hospital where he had worked for most of his life. A huge heart, covered in flowers stood behind the casket...
68 Responses
Oct 10, 2012
The Prisoner Has Escaped! - A bride tells her husband, "Honey, you know I'm a virgin and I don't know
anything about sex. Can you explain it to me first?"
"OK, Sweetheart. Putting it simply, we will call your private place 'the
prison' and call my private thing 'the prisoner...
39 Responses
Sep 2, 2012
The Best Pick Up Line Ever - A Scotsman walks into a bar and takes a seat next to a very attractive woman, he gives her a quick glance, then , casually looks at his watch for a moment
Now, the woman notices this, and asks him, Is your date running late ?
NO he replies i just got...
43 Responses
Jun 1
Subjects for A Date
A boy is about to go on his first date, and is nervous about what to talk about. He asks his father for advice.
The father replies: "My son, there are three subjects that always work. These are food, family, and philosophy."
The boy picks up his date and...
4 Responses
4 days ago
THE Blonde Joke to End All Blonde Jokes - A blonde woman was speeding down the road in her little red
> sports car and
> was pulled over by a woman police officer who was also a
> blonde.
> The blonde cop asked to see the blonde driver's
> license...
145 Responses
Jan 16, 2009
Is this yours???
Paddy says to Mick
"I found this pen, is it yours?"
Mick replies "Don't know, give it here"
He then tries it and says "Yes it is"
Paddy asks "How do you know?"
Mick replies, "That's my handwriting"
1 Response
4 hours ago
My Daily Joke .... Why Did the Chicken Cross the Road? - Why did the chicken cross the road?:
PAT BUCHANAN: To steal a job from a decent, hardworking American.
DR. SEUSS: Did the chicken cross the road? Did he cross it with a toad? Yes! The chicken crossed the road, but why...
37 Responses
Nov 5, 2006
Olympic Condoms - A man is out shopping and discovers a new brand of Olympic condoms. Clearly impressed, he buys a pack. Upon getting home he announces to his wife the purchase he just made. "Olympic condoms?", she blurts, "What makes them so special?" "There is three colours...
18 Responses
May 9, 2011
Chemistry Exam - Chemistry exam.
The following is an actual question given on a University of Liverpool
chemistry final exam.
The answer by one student was so "profound" that the professor shared it
with colleagues via the Internet, which is why we now have...
24 Responses
Dec 18, 2006
Down South, Bubba called his attorney and asked, "Is it true they're suing the cigarette companies for causing people to get cancer?"
"Yes, Bubba, sure is true." responded the lawyer.
"And now someone is suing the fast food restaurants for making them fat and clogging...
2 Responses
4 days ago
Radio Healing
A husband and wife are listening to a man on the radio who claims he can heal any part of the body. 'Place one hand on the radio and the other on the part that needs healing,' says the man. The wife places one hand on the radio and the other on her heart. The...
1 Response
1 day ago
The Irish Prostitute - An Irish daughter had not been home for over 5 years. Upon her return, her Father cursed her heavily.
'Where have ye been all this time, child? Why did ye not write to us, not even a line? Why didn't ye call? Can ye not understand what ye...
61 Responses
Jan 3, 2011
Caily Joke.......too Tired For Romance - Too Tired For Romance
Jenny's husband, Charley, was a male chauvinist. Even though they both worked full-time, he never helped around the house. Housework was woman's work!
But one evening Jenny arrived home from work to find the...
12 Responses
Nov 7, 2006
My Daily Joke...suspicious Mother - Suspicious Mother
Brian invited his mother over for dinner.
During the course of the meal, Brian's mother couldn't help but keep
noticing how beautiful Brian's roommate, Stephanie, was.
Brian's Mom had long been suspicious of a...
32 Responses
Nov 6, 2006
Silk Pyjamas - A man called home to his wife and said:
"Honey I have been asked to go fishing up in Canada with my boss and several of his friends. We'll be gone for a week. This is a good opportunity for me to get that promotion I've been wanting, so could you please pack...
40 Responses
Aug 21, 2011
An elderly couple have finally learnt how to send texts on their mobiles. The wife, being a romantic at heart, sends her husband a text while he's out. It reads: I love you. If you are sleeping, send me your dreams. If you are laughing, send me your smile...
2 Responses
1 day ago
The Emotional Development of the Male.
Here is a summary of the main concerns of a typical male at various stages of life:
0 - 5 years: pooping
5-15 years: sports
15-25 years: sex
25-35 years: sex
35-45 years: sex
45-55 years: sex
55-65 years: sex
65-75 years: pooping
2 Responses
1 day ago
CATHOLIC COFFEE MORNING IN ROME--Four Catholic men and a Catholic woman were having coffee in St. Peter's Square.The first Catholic man tells his friends, "My son is a priest. When he walks into a room, everyone calls him 'Father'."The second Catholic man chirps, "My son is a...
4 Responses
5 hours ago
This Is Priceless - I used to be like this...
Then I met a girl...
She was like this...
Together, we were like this...
I gave her gifts like this...
When she accepted my proposal, I was like this...
I used to talk to her all night like this..
And at the office I used to do this...
47 Responses
Apr 2
The Irish Diet. An Excellent Weight Loss Idea
An Irishman was terribly overweight, so his doctor put him on a diet.
'I want you to eat regularly for 2 days, then skip a day, then eat regularly again for 2 days then skip a day ... And repeat this procedure for 2 weeks. The...
4 Responses
4 days ago
Riddle Me This, Riddle Me That - There was once this man who requested to see both heaven and hell before dying. So when he went to hell, he saw people sitting around a circle table with the food in the center trying to feed themselves with ten foot long chopsticks. They were all...
20 Responses
Nov 6, 2006
Never Assume That Men Understand. - A woman was in a coma. She had been in it for months.
Nurses were in her room giving her a bed bath. One of them was washing her private area and noticed that there was a slight response on the monitor whenever she touched her there. They...
117 Responses
Dec 16, 2010
Linda's Daily Joke...........men Are Like....... - Men Are Like...
Men are like a deck of cards....
You need a heart to love them
A Diamond to marry them
A Club to beat them
And a spade to bury the bastards
39 Responses
Nov 3, 2006
White Hairs
One day, a girl walks to her mother and look at her mother's hair and sadly said: "Why are some of your hair white mom?"
The mother replied, "Well, every time that you do something wrong and make me cry or unhappy, one of my hairs turns white.
The girl thought about...
3 Responses
4 days ago
A school teacher injured his back and had to wear a plaster cast around the upper part of his body. It fit under his shirt and was not noticeable at all.
On the first day of the term, still with the cast under his shirt, he found himself assigned to the toughest...
2 Responses
3 days ago
Cell Phone EtiquetteAfter a tiring day, a commuter settled down in her seat and closed her eyes. As the train rolled out of the station, the guy sitting next to her pulled out his cell phone and started talking in a loud voice:"Hi sweetheart, its Eric. I am on the train.""Yes, I...
4 Responses
4 hours ago
Italy Vs. Greece - A Greek and Italian were arguing over who had the superior culture.
The Greek says, "We have the Parthenon."
Arching his eyebrows, the Italian replies, "We have the Coliseum."
The Greek retorts, "We Greeks gave birth to advanced mathematics"
The Italian...
25 Responses
May 10, 2011
Very Funny - Someone passed this along to me and I just had to share it!
Take off clothing and place it carefully in laundry hamper according to 'lights' and 'darks'. Walk to bathroom wearing long robe. If you see husband along the way, cover up any...
38 Responses
Sep 20
Entertainment Night It was entertainment night at the senior citizens' center.
After the community sing along led by Alice at the piano, it was time for the star of the show- Claude the Hypnotist!
Claude explained that he was going to put the whole audience into a trance...
2 Responses
16 hours ago
Drummer Problems
A musical director was having a lot of trouble with one drummer. He talked and talked and talked with the drummer, but his performance simply didn't improve.
Finally, before the whole orchestra, he said, "When a musician just can't handle his instrument and doesn...
3 Responses
4 days ago
Union Shop
A dedicated shop steward was at a convention in Las Vegas and decided to check out the local brothels.
When he got to the first one, he asked the madam, "Is this a union house?"
"No, I'm sorry, it isn't" , said the madam.
"Well, if I pay you $100, what cut do the...
3 Responses
4 days ago
Christmas Carols
Back in my drinking days I realized that it was better to go Christmas caroling in a group.
I also realized it was better to go caroling in the middle of December.
1 Response
14 hours ago


text:
For the second year in a row, the Norwood Mavericks football team is undefeated going into the semifinal round of the state playoffs.
Ty Williams repeats as 2A State Champ; THS girls' team finishes fifth at state's preeminent meet.
Local ski star Gus Kenworthy will appear live with the new feature The Way I See It screening in Telluride Nov. 6.
Telluride beats Ridgway in thrilling homecoming soccer match, 1-0
12-hour downhill biking blitz comes to Mountain Village Bike Park this weekend.
Heart of Telluride run comes to Telluride Oct. 2
Brian Cushing didn't take a banned fertility drug but, instead, has a unique medical condition called overtrained athlete syndrome.
Once again, Brett Favre has taken the spotlight.


text:
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This system is easy to use—simply plug into your audio mixer or amplifier in place of your wired microphone. Advanced audio processing circuitry gives you a wide dynamic range with no overloading for loud inputs or background hiss during quiet use. Controls include a Front panel Power On/Off switch with a Power On LED for easy operation. The back panel has a ¼" audio output jack and DC power input jack for AC/DC adaptor. Special circuitry eliminates transmitter on/off "pop" noise.
Get the freedom to deliver your best speach, presentation, or performance. Order today.
Our product catalog varies by country due to manufacturer restrictions. If you change the Ship-To country, some or all of the items in your cart may not ship to the new destination.


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text:
The Scientist's annual competition uncovered a bonanza of interesting technologies that made their way onto the market and into labs this year.
The Scientist's annual competition uncovered a bonanza of interesting technologies that made their way onto the market and into labs this year.
Researchers are piecing together the devilishly complex sets of genetic alterations underlying schizophrenia and bipolar disorder.
Deep-brain stimulation is allowing neurosurgeons to adjust the neural activity in specific brain regions to treat thousands of patients with myriad neurological disorders.
Expectations can make you ill. Fear can make you fragile. Understanding the nocebo effect may help prevent this painful phenomenon.
Research into how the brain suffers as a result of chemotherapy is revealing potential avenues for ameliorating cognitive decline.
Researchers are taking advantage of small, transparent zebrafish embryos and larvae—and a special strain of see-through adults—to understand the development and spread of cancer.
Patients are sidestepping clinical research and using themselves as guinea pigs to test new treatments for fatal diseases. Will they hurt themselves, or science?
The remarkable ability of the star-nosed mole to interpret its surroundings through touch is yielding clues about mammalian sensory processing in general.
Scientists hope an understanding of nerve fibers responsive only to gentle touch will give insight into the role the sense plays in social bonding.
To cope with a growing shortage of hearts, livers, and lungs suitable for transplant, some scientists are genetically engineering pigs, while others are growing organs in the lab.


text: I"ve got these two nifty new LED side mount port and stbd. running lights and I'm having trouble deciding where to mount them. The boat is 38' LOD with a 6 1/2' bowsprit, no pulpit. The original idea was to fasten them to the outsides of the bulwarks back a bit from the bow, but because of the inward curve at the stem they would need some thick wedge shaped mounting blocks under them so they would line up with the centerline of the boat and show the lights in the proper directions. I think they're going to look like two warts sticking out of the bulwarks. Anyone have a better idea? I could mount them on boards on the shrouds, but these lights are very small (1 3/4" X 2 3/4") and would look lost mounted that way. The lowers are about 4' apart.


text:
To obtain up-to-date Gardiner Area High School Sport Schedules's and information visit: High School Sports . Click into the box labeled: Find your High School and type Gardiner's Zip Code: 04345. Once the zip code is entered click submit and choose GAHS from the options. All schedules are automatically update as needed.
Enrollment is free and entitles you to special features like email notification of any changes that effect the schedule.
Web Link Disclaimer: All links leaving the Gardiner Area High School/MSAD#11 web site are provided as a convenience. MSAD#11 does not endorse or have any responsibility for the content of the outside websites.


text:
I saw the rumor from TMZ during dinner tonight.. I was happy to see that it was just another internet hoax and that he was all good! Turns out though, it was true.. Very sad news to have to break to you this evening on the air and on line.. One of my all time favorites gone to soon.. Way to soon. Just another reminder that Life is short.. Make the best of it every single day.. R.I.P. Paul.. Thank you for decades of great entertainment!
Photo Credit - Ghetty Images


text:
Play cards -- like Anima/us: Understand Relationship, Family: Hidden Connections, or Trickster: Break the Rules -- to affect the setting, NPCs, or plot of your game! Each Imago card is ti... [click here for more]
In Dead Inside (DI), the Real World is the same as the world we all live in. . . a cold, hard world where spiritual power is weak. Still, the supernatural beings of the Cosmos -- Dead Inside, Sensitives, Magi, Ghosts, Zombis, and Free Spirits -- bring their subtle horrors, mysteries, and wonders with them into the everyday: hiding behind corner... [click here for more]


text:
2012-04-24 18:59
Marathon walk raises global awareness of natural disasters
By John Redmond Three hundred expatriates representing the four corners of the globe joined together at Seoul Grand Park for marathon walk "10km in Their Shoes" on a beautiful spring afternoon on April 7. This event, organized by volunteer group Mannam, focused on countries that have suffered from a natural disaster on a large-scale within the past two years. It highlighted Japan, Turkey, Thailand, Pakistan, Chile, and Haiti, where people are still recovering from catastrophes that struck their homes. Participants were asked to choose a country to walk for as they trekked the 10 kilometers around the zoo. They proudly displayed a sticker of the nation's flag on their faces as they walked. Across the nation, some 1,000 people took part in the campaign by walking and writing messages of hope to the six countries in focus. Volunteers and expats met in seven different cities on the southern part of the peninsula and walked at the same time to raise awareness. Besides Seoul, Mannam branches in Busan, Chuncheon in Gangwon Province, Jeonju in North Jeolla Province, Incheon, Daejeon and Gwangju held a 10 kilometer walk as well. A Mannam member from Saudi Arabia, who wished to remain anonymous, explained that this is the type of work in which he is interested. "Volunteer work is something that you are attracted to because it's for humanity." He walked to support the nations of Turkey and Pakistan, which are still recuperating from last year's earthquake and major floods, respectively. Mannam International Running Club member Melvin Galera was also proud to take part in the campaign. He said that although he cannot personally go to Japan and help the victims of the earthquake and tsunami, he feels that he can support them by taking part in this marathon. "I feel for Japan and want to give them a message of hope," the Philippine native said. "Despite what's happened, I believe you can move on." A student from Turkey, who only gave his first name, Kamal, was moved by the number of people who gathered at the event to remember and share in the sufferings of people miles away. He stated, "I would like to thank every participant that supports this event. I'm happy to know that Korean people still keep the friendship that leads to peace." "The walk is an on-going campaign to bring awareness to the people of South Korea as well as those abroad. It is essential to send the message that we support and embrace those suffering around the world as we are one global family," read a press release. For more information on Mannam Volunteer Association, visit www.mannamintl.org. |