text:
A Triumph in the War Against Cancer
Oncologist Brian Druker developed a new treatment for a deadly cancer, leading to a breakthrough that has transformed medicine
- By Terence Monmaney
- Photographs by Robbie McClaran
- Smithsonian magazine, May 2011, Subscribe
(Page 7 of 8)
"When did that start?"
"About ten weeks ago."
He asked about the rash, and later I would leave the room so he could examine her.
"You still working at the food bank?" he asked.
"I'm doing one day a week."
"How's that going?"
"How's your energy?"
"My energy is low. But my brain is active."
"You're just doing spectacularly, leukemia-wise."
"I know it. I can feel it."
"What else? Questions for me?"
"I'm going on a trip tomorrow."
"San Diego and Knott's Berry Farm with all my grandkids." She updated their progress, and Druker recited their ages, as if to check that he had the facts right. When he addresses scientists at professional conferences, he often shows photographs of LaDonna and her grandchildren. Contrary to all expectations, he says, she is getting to watch her great-grandchildren grow up.
Subscribe now for more of Smithsonian's coverage on history, science and nature.
Related topics: Disease and Illnesses Treatment Theories and Discovery Scientific Innovation
Comments (54) |
Ponatinib is one of the medications currently under investigation for its ability to treat CML and ALL (via http://www.rxwiki.com/ponatinib). Is there any news on when this will hit the market?
Posted by dailyrx on December 13,2012 | 03:36 PM
Dr. Druker well deserves Nobel Prize! His work ushered the era of effective treatment of metastatic stage IV melanoma, for example. For 40 years no one knew how to effectively combat this disease. It killed a lot of young people, including Bob Marley. PLX4032 (aka vemurafenib, trade name Zelboraf) is now FDA-approved. GSK prepares even better stuff- dabrafenib+tamatenib (BRAF+MEK inhibitor combo). Now the research in targeted therapy is exploding, and Dr. Druker ushered this watershed!
Posted by Gregory Pribush on October 24,2012 | 07:40 AM
this was very well writen. it's very thourgh amd keep writing stuff like this i enjoy reading it.
Posted by bryan wines on May 22,2012 | 02:16 PM
Posted by jneppz on May 2,2012 | 01:06 PM
Dude you a boss thanks man you awsomes
Posted by Munoz on May 2,2012 | 01:05 PM
My mother was diagnosed with lukemia 11 years ago. she had from what i can understand two types, of the blood and of the bone marrow. they doctors here in spain managed to cure her of the blood but she has been on gleevec to treet the bone marrow for the past 11 years. in the past year she has been suffering from problems, fatuige, water retention, and she has been told after blood tests that she is very aneemic. they started giving her injections and pills to balkance her iron deficiency out but in the end they have found out that it is the gleevec that is causing the problem. in the last week they have taken her off gleevec and she has started taking another medication. as a result it has knocked her for 6 and she can barley walk around . they had to give her an emergency blood transfusion two days ago and it has made her worse. she is suffering from vomiting and nausea, and is constantly sleeping or out of breath. she has no apitite at all and no energy. I was suprised that they did not keep her in at the hospital to monitor her after the transfusion but i suppose due to all the doctors and nursing cuts here in spain, she would just be filling up another bed. i am truly conserned about her. do you have any suggestions as to how she sould prosceed and is what she is going through normal after a medication change and transfusion ? i would very much apreciate your advice.
many many many thanks,
Frank from spain, mallorca
Posted by frank on January 21,2012 | 01:40 PM
It is truely amazing how Gleevec came to be. Thank You Dr. Drunker and all the other doctors who put forth the effort to bring this to us. My husband was dx Sept 17 2003 intially statred gleevec for two years then he became resisant. He actually particapted in first phase trials for sprycel which actually just concluded a couple months ago. What a blessing for us to have this drug and several more if needed.
Posted by Tammy on October 13,2011 | 01:30 PM
I was so excited to read this article a friend told me about it. It was nice to see the person who came up with this drug. Praise the Lord Dr. Druker found this and he wanted to help others. So glad he he didn't give up. I was just diagnosed with CML August 15, 2011. Praise the Lord I don't have to go through the agony so many others have endured. What a mighty God we serve!! :)
Posted by Angie Burns on September 24,2011 | 10:42 AM
I have Hemochromatosis for over 20 yrs & was recently found to be in early stage of CLL which was confirmed by 2 blood tests. I also am slightly Anemic. I am 81 yrs young and in general good health. If there are any test programs I would be interested.I am presently being monitored at Sloan Kettering
ThANK YOU.
Posted by susan miller on August 6,2011 | 03:12 PM
I was diagnosed with a very rare form of CML after a routine blood test in August 2005. The difference versus regular CML is that my mutated gene is 5;12 and not 9;22. I was blessed to have been offered Gleevec through M D Anderson, Dr. Susan O'Brien and Lizzy Pavel PA and I'm in a testing protocol for my rare form of CML like disease. To make a long story short, I've been in complete remission for 6 years since taking Gleevec in November 2005. I thank God first, and al the researchers and MD's that made this targeted cancer drug successful and available. I hopeful that by being in a testing protocol that the drug will be available to anyone who needs it. Gleevec is still not FDA approved for my disease, therefore not available through Medicare D. The only way I got the Gleevec in 2006 was through a company retirement secondary benefit drug program. I got the Gleevec to in November 2005 and then our wonderful government took it away me in early 2006 when Medicare D stared. I have only contempt for our wonderful Medicare D program. After all, the only reason to have medical insurance like all insurance, is to cover the very serious situation. After paying into system at max. Level for 40 plus years, the medicare drug wasn't,t there when I needed it!!!
Gleevec worked for me and I continue to monitor blood and bone marrow once a year at M D Anderson in Houston.
When I hear about previous treatments for this blood disorder, I, so blessed to have Gleevec. Thanks be to God, I'm truly grateful!
Posted by Charles Hannah on July 14,2011 | 05:00 PM
After reading this wonderful article, Dr Brian Druker is my hero! Last month my dear brother, William E. Barnett of Williamsburg, VA was diagnosed with CML! Thank goodness for Dr Druker's research to discover the "miracle drug" Gleevac! In 1 1/2 months he is back to work and doing great! There are no words but to say "Thank You, Thank you!" over and over again.....
Bud's sister in California
Posted by Cindy R. Jagger on July 5,2011 | 09:01 PM
Would this drug help ALL patients?
Posted by Tina McAninch on July 5,2011 | 10:09 AM
Cancer is one of the most typical diseases in the Western countries. Its seriousness is seen in many countries where as many as every third person dies of it, and it is the second most common cause of death immediately after the cardiovascular diseases. Especially cancer of the lungs has become very common, and for example in the United States, it takes more victims than any other type of cancer.
Posted by telson on June 27,2011 | 12:47 AM
My Dad is 72 and is currently going thru chemo for AML..can this drug help him?
Posted by Scott on June 22,2011 | 01:35 PM
Thank you, Rick Weinstein, for writing in. I am not familiar with the medical literature on CLL and would not presume to offer medical advice. A list of clinical trials tracked by the National Institutes of Health can be found at http://clinicaltrials.gov/
Best wishes,
Terence Monmaney
Posted by Terence Monmaney on June 15,2011 | 01:08 PM
My story is I was diagnosed in Mar 2011 with CLL and asymptomatic at that. My WBC has risen from 18,000 in Mar to 25,000 last week. My situation is not desperate like many CML cases. However, I feel like a sitting duck waiting for the blast. Are there any targeted therapies in the works for CLL? I imagine there must be since there are many more cases of CLL than CML, not to diminish in any way, the impact on every person who receives a leukemia diagnosis.
Posted by Rick Weinstein on June 6,2011 | 11:26 AM
Dr. Druker,
I was diagnosed with DFSP on my scalp, as you probably know it has a low rate of metasis in most case, but is very debilitating at the site. Many people have gone through disfiguring surgeries and have experienced chronic pain due to the surgery. I was told of gleevec by one of my doctors and told my surgeon Dr. Valencia Thomas at MD Anderson I wanted to try it before surgery. They all agreed, and I was on it for only close to four months!!They removed the site all the way down to the skull, NO DFSP in the deep tissue or anywhere in the entire area!! Thanks to God first and second to you and your hard work and discovery of Gleevec. You have a reason to smile 24 hours a day because YOU have made a difference in the lives of so many others. Dr. Brian Druker, thank you.
Lisa Salinas-Gruver
Austin, Texas
Posted by Lisa Salinas-Gruver on May 17,2011 | 10:59 PM
Crystal - The public has hardly been misled. Rather, they are being educated. Gleevec and similar medications are not taken for the short term, but for many years. Consider for example, myself who has had CML for almost 20 years. During that time I've taken 3 drugs to treat the disease, of which Gleevec was only one; however the others were/are of similar cost. So far my medication has cost almost $1,400,000, give or take a few. Since I am only 50 and in very good health, I hope to live a long time yet, during which time Novartis stands to make a whole lot more. Still think it's fair? Obviously R&D takes money, and yes, the shareholders need their part.
And Crystal, the word is "gouge" as opposed to "gauge" - a whole other meaning. And yes, Novartis is gouging.
That being said, my gratitude to Brian Drucker is imossible to measure, A thousand thank yous could never be enough.
Posted by Anita Rowland on May 12,2011 | 02:41 PM
Diagnosed with CML in August 2006 and started Gleevec early October 2006. Feared I would not live to turn 60. The grandchildren's eyes really got big when they saw the cloud of smoke from blowing out 60 candles in April 2007. Have been an avid "fan" of Dr. Druker's ever since. I have a brother in Battle Ground, WA and a sister in Seattle. Next trip to the Pacific Northwest will include, hopefully, an opportunity to shake Dr. Druker's hand and get a picture with him! Yes, he is my hero! A special Thank You to his wife and children; 60-80 hrs a week isn't much fun for those at home. His accomplishments are a blessing to me every day.
Posted by Jennie on May 10,2011 | 12:25 AM
I thank God and Dr. Druker for saving my life. My story is very similar to LaDonna Lopossa's. After being single and serving the Lord for 28 years, I was just planning on getting married to a wonderful man when I was diagnosed with CML and given 5 years to live, if I survived the bone marrow transplant... I was not eligible for the experimental trials at that time (year 2000). We decided to elope anyway! As it turned out, there was no bone marrow match for me, so that was out of the question. I was put on interferon. Just like LaDonna's story, the pain and side effects were so horrendous, I just stopped taking it, "come what may." Thankfully, miraculously after that, I was called to participate in the drug trials. That was ten years ago and I am still alive and happily married. Thank You, Lord, and God bless Dr. Druker and his family.
Posted by Judy Grenz on May 10,2011 | 11:50 AM
THANK YOU VERY MUCH Dr. Druker,you saved my life!!! I started treatment with Gleevec 10 years ago, 1 month before FDA approval. My CML dignosis was back in 1995. I went to OHSU to be treated and I met a wonderful team that gave me all its support to go on in this battle again this horrible disease. GOD BLESS ALL OF THEM!!
Posted by Alex on May 9,2011 | 02:35 PM
I just read your article on Dr.Drucker and Gleevec with great interest because I was diagnosed with a rare cancer called dermatofibrosarcoma (DFSP) last summer. This rare cancer was only able to be treated by surgery until gleevec. If my cancer comes back I have that option if they can't operate again. Gleevec may someday save my arm or even my life. I can't thank the good Dr. enough for his work. The mutation in DFSP is a chromesone translocation(17,22). Angelina Wilson
Posted by Angelina Wilson on May 8,2011 | 01:44 PM
LaDonna Lopossa is my mother! There are few words for what this Drug and specifically Dr. Druker has meant to our family. The experience of having a doctor tell me that my mother would die was my worst nightmare. To then have Dr. Druker say that she may live gave me hope and to then have him say,just two weeks later, that she was getting well was my greatest joy. I am having brunch with her today on a Mother's Day that might not have been. It was certainly a miracle for us. Thank you for your kind thoughts and words.
To John Nienstedt: Smithsonian is an academic magazine. If you find the articles to lengthy, perhaps you should read People Magazine. I will share with my mom the Betty Grable comparison. I think she will love that.
Posted by Kelly Schaefer on May 8,2011 | 10:44 AM
LaDonna Lopossa is my granny! Dr. Druker REALLY is our hero. I was 11 years old when she was diagnosed and didn't really understand anything beyond "Grandma is very sick." In the years since, I've realized just how incredibly sick she was and how miraculous her remission is thanks to Dr. Druker. I love her so much and I am ever mindful that because of him, my granny got to be at my graduation, play matchmaker and set me up with the man that is now my husband, and meet our two beautiful babies. :)
Posted by Julia Bennett on May 7,2011 | 01:38 AM
Thank you for the well written story and thank you to Dr. D for saving my life and so many others' lives.
When I was diagnosed, I wanted to delay treatment because I had a trip planned and my doctor didn't want me to travel with the possbility of serious unknown side effects after starting Gleevec. So I proposed waiting( even though my white blood cells were approaching the stratosphere). Being sarcastic I said, What; am I going to die if I don't start treatment?" He said, "yes." That was four years ago and thanks to Gleevec and the second , third and fourth generation drugs, I have a pretty normal life. Most importantly, I have life.
I agree with the other person who posted- Where is the movie?
Posted by Chi Neal on May 6,2011 | 12:52 PM
I was diagnosed in November, 2006 and was immediatley put on Gleevec. I'm in total remission and have been since about 3 months after my first dose. I'm embarassed to say that I didn't know the history of how this drug came about but I do know. I'm sure Dr. Druker receives daily thank you's and here it mine.
As to the cost of the drug - I was very fortunate to have friends that knew how to work the patient assistant program at Novartis. One friend that worked for a doctors office actually backed the Novartis drug rep in a corner and would let him leave until he had made the contacts we needed to get the assistance. Norvatis is very generous with their program but my biggest fear is that someday that generosity will stop.
Thank you Dr. Druker and Norvatis for your great contributions.
Posted by Liz Veazey on May 5,2011 | 11:12 AM
Terence, thank you for your story. Dr. Druker is our hero also. My husband Tim has GIST, with huge metastases in his liver. Because of Gleevec Tim is alive today and those tumors are now all calcified and hopefully dead tumors. He has been on Gleevec 6 1/2 years, feels great, looks great, and is living a normal life. Dr Druker is in our prayers every day and every night.
Posted by Gail Mansfield on May 4,2011 | 11:12 PM
After suffering a series of 3 strokes, my father was finally diagnosed with a form of blood cancer called essential thrombocytosis about 6 years ago. Since then, like some patients with CMS, he has been treated using hydroxyurea. Although platelet count seems to be well controlled, he continues to have "spells" (passes out) from time to time, and I am aware that his condition could evolve into acute myeloid leukemia with long-term use of hydroxyurea. After reading the Smithsonian article about Dr. Brian Drucker, I was wondering if there was any new therapy that might be better for my father's condition.
Posted by Jude on May 4,2011 | 07:55 AM
We would also like to thank Dr Druker and the teams involved. My daughter was 13yo at her dx 18 months ago, she is still heading towards all the zeros but doing a whole lot better than her unexplained illness 18.1 months ago. I do fear for the longer term for her, not only from the dx side but also what the drug may do in the longer term - because she is so young. Wish I had complete answers about the future. Nobody has a crystal ball though, take each day as it comes :-)
We are so completely happy she is still with us, and living life relatively normally again, thank you - all.
Posted by S Smith on May 3,2011 | 10:41 AM
I'm a new victim of CML. I discovered my condition 2 months ago, and started Glivec with spectacular response. I read the article. The least I can say is that this saga should be made into a movie. THANK YOU Dr. Brian Druker for saving so many lives including mine. God bless you.
Posted by AHMED ELSADR on May 1,2011 | 04:59 AM
Is there any such magic pill for AML? Any information will be helpful.
Posted by Sheila on April 29,2011 | 02:12 AM
The article did a good job in informing the genearal public how things are done in R&D(research and development) world. However, as a pharma insider, I have to pooint out this is not a complete picture. The author implies the high price is "gauging' the patients. He failed to give some hard facts, including it takes on average 12 years and $1.2 billion to put a drug through. The patent life of 20 years starts from when a molecule is registered right after it's synthesized. That gives only 8 years of protected life by the time it's approved, if it's approved at all. The matter of facts is, >99% of molecules would not even make to clinical trial. They are killed at various stage for various reasons, mostly due to issues in safety, secondly efficacy. For those made to market, <5% will become a blockbuster like Gleevec, with vast majority will not make pay for the development cost. Companies must use the revenue from a few successful products to underwrite the entire R&D. With increasingly stringent political environment, the cost of drug development is skyrocketting. The bar set by FDA to proof a drug worth marketing is incredibly high. Using one analogy, by today's regulatory standard of drug safety, aspirin will not be approved!
I hope the magazine encourages their writers to provide a balanced view, instead of misleading the public.
Posted by Crystal on April 29,2011 | 04:11 PM
Terrance, I want to say how beautifully this story is written. The opening graphs are especially artful. Well done and thank you.
Posted by Kathy Price-Robinson on April 27,2011 | 08:34 PM
My 9 year old son was diagnosed with CML 3 years ago. He has been taking Gleevec since he was diagnosed and we flew across the country to meet Dr. Druker. In the world where people idolize performers and sports players, Dr. Druker is my hero.
Posted by Julie on April 27,2011 | 03:07 PM
My dear sister in law was a part of that study. Thank you Dr. Druker and thank you God that she is still with us. God bless you!
Posted by Cheryl Pippin on April 27,2011 | 03:05 PM
I was diagnosed with CML in January of 2002 and Gleevec and Dr. Druker's work has allowed me to live a productive life since my diagnosis. I will be celebrating 10 years on Gleevec in less than a year! Only one bump in the road and that took an increase in the dosage. I don't have all the side effects that I read about from other patients and if I did it is a good trade-off!
Posted by Richard Jones on April 27,2011 | 08:57 AM
John, "get to the point quicker?" Are you serious? If you had CML, you would not be so quick to judge the article. Without Gleevec, a person who has CML or in fact GIST, had a life sentence of 5 years. Gleevec took the 5 year mark away and made it disappear. This is why Gleevec is called "The Magic Bullet." I am glad that the article shows the human side of what transpired. It makes it a more personalized story, not just medical.
The history behind the development IS personal and humanistic.
Sorry you viewed this article that way.
I am now an 8 year survivor!
Thank you, Dr. Druker, for keeping me around to witness both my sons getting married....THANK YOU!
Posted by Susan Rosenthal on April 26,2011 | 08:16 PM
I was diagnosed with CML on 10/15/07. You never forget dates like that. I can relate to the stories of enlarged spleen, pain and fatigue before treatment. After several months on hydroxyurea and recovery from kidney surgery, I started on Gleevec on 1/4/08. I have been in remission with undetectable cancer levels since November of 2009. There are unconfortable side effects, but I would not go off the drug for the world. It has given me back my life! People think I am crazy when I say I am the luckiest guy I know, but I am; I got just the right cancer that had an oral chemo pill for treatment, and it works. Thank you Dr. Druker!
Posted by Steve Main on April 26,2011 | 06:02 PM
Mark Lavender's comment asks why the story doesn't mention GIST, or gastrointestinal stromal tumor, an afflictionn also mentioned in Terri Morgan's comment. Good question. The answer is that the story is already rather long and complex, and bringing in another genetically complicated disease risked taxing the reader's patience. But Gleevec does play an important role in controlling GIST (and several other afflictions besides CML), and, significantly, Brian Druker was involved in the early research on the drug's action against GIST. Thank you, readers, for your feedback and close reading of the story.
Posted by Terence Monmaney on April 25,2011 | 04:21 PM
On the other side of the coin, I found all the personal details very humanizing and they made for me a much more pleasurable reading experience. I find strictly clinical reports not only difficult to enjoy, but also more easily forgotten. I know I will remember Dr. Druker and his accomplishments for a very long time.
Posted by Carol Ross on April 25,2011 | 02:07 PM
I was diagnosed with GIST (gastrointestinal stromal tumor), a rare form of cancer, 4 1/2 years ago and am taking Gleevec. I know how much this drug means to CLM and GIST patients who live wth hope instead of a death sentence. We owe our lives to Dr. Druker and hope other doctors and scientists are as successful and determined in finding a cure for CLM, GIST, and the other cancers. I found the entire article very interesting but wish more had been mentioned about and Gleevec and GIST earlier in the article. GIST can be hard to diagnose and this article could have helped spread information regarding a little-known cancer to doctors and patients.
Posted by Bonnie Emerson on April 25,2011 | 01:49 PM
The drug Gleevec saved my brother Geoffrey's life. He is a 17 year survivor. He was originally part of a clinical trial at MD Anderson when the drug was called STI571 I had the pleasure of meeting Dr. Druker when he visited South Florida and expressed my appreciation and gratitude.
Posted by GORDON LATZ on April 25,2011 | 10:54 AM
I have CML and I want to say thank you Dr. Druker for believing in yourself.
Posted by Robin Keeler on April 24,2011 | 04:07 PM
This is indeed a miracle. My father-in-law died of this disease, and I was surprised that this treatment has been around this long - and more surprised that he wasn't given the drug. It may have been that he was 86 and on Medicare. Seems to me that if they know what gene is causing it, that there might be some sort of gene therapy that can be done to "turn it off" before it gets turned on. If at least one parent has the gene, then their child has a higher chance of having it as well.
As a family member of someone with a genetic disorder related to tyrosine enzymes (specifically PKU, and it's lack of production of Phenalyanine Hydroxylase), I'm anxious to hear of any news in the direction of enzyme therapy.
Posted by Debi on April 24,2011 | 12:28 PM
Gleevec is a very important drug in the fight against GIST -Gastro Intestinal Stromal Tumour. Why no mention of this?
Posted by Mark Lavender on April 24,2011 | 03:01 AM
Gleevec is also used to treat a fairly rare form of cancer, called GIST (Gastro-Intestinal Stroma Tumor). Before it was introduced, the mortality rate for GIST sufferers was 65% within 5 years. Now there is no telling how long a patient may live - and live a normal life; working, gardening, raising families and everything else.
I have GIST. I am extremely grateful for the work that enabled my surgeon and oncologist to tell me that while I had cancer, my chances of dying of it quickly were very improbable.
Posted by Terri Morgan on April 23,2011 | 04:01 PM
As a CML patient I'd like to thank you for focusing on the human side in your story. There are hundreds of articles on the technical side, but there has been far too little focus on the personal elements of Dr. Druker's work and on the patients who contributed so much to others by participation in clinical trials and sharing information through the Internet and other forums.
While the "miracle cancer pill" aspect of this story gets a lot of attention, meeting the needs of patients who are now living with a lifetime of drug therapy, side effects and costs does not. Fortunately there are now organizations to support patients who are living with CML instead of dying.
In the US, there is the National CML Society. In Canada, there is the CML Society of Canada. Support groups representing 54 additional countries can be found at the CML Advocates Network website. Patients are newly diagnosed with CML every day, and like all cancer patients, need support and resources to move forward and make the most of each and every day. Thank you again for sharing our story.
Posted by Pat Elliott on April 23,2011 | 02:19 PM
What a wonderful story. My son who is 30 has cancer, he has a neruo endocrine tumor. This is a rare cancer we have been told, I hope that they will soon have a cure for this type of cancer also.
Posted by Mary Jenkins on April 22,2011 | 08:50 PM
I have CML and have taken Gleevec for 1.5 years. There is nothing quite as frightening as a cancer diagnosis, and nothing quite as amazing as what Dr Druker has done to address it for CML patients worldwide.
His determination to develop this drug despite many challenges is greatly appreciated.
Dr. Druker even took a phone call from my oncologist when I had some mysterious side effects (later proven unrelated to Gleevec).
He is a hero. He has potentially changed the way all cancer will be addressed in the future.
Katherine Pastre
50 year old mother of three, diagnosed 9/22/10.
Posted by Katherine Pastre on April 22,2011 | 12:28 PM
It is notable story of how patient has been treated by the doctor with his full faith and broad-mindedness.
Posted by barcode label software on April 21,2011 | 02:07 AM
The treatment is indeed miraculous - my concern is about the cost of treatment which even for patients in the U.S. is very high. Unless he belongs to the top 1% of the super rich what chance does an ordinary patient in India have to be treated with the wonder drug ?
This is NOT criticism but an observation of the way things are in my country as far as critical disease medical treatment is concerned.
Posted by Ashok Rajadhyaksha - Mumbai (India) on April 21,2011 | 01:28 AM
I am a 63 year old woman dx with cml 8-1-2007
I was put on gleevac immediately within 1 month my bw was fine.
I was told cml was rare and usually affected middle age people.I am on a cml discussion board
Over the last few months so many young people have come to our site. From ages 19-37, Most of them have small children and work full time,or they just finished college,some of them just got engaged or only been married a short while.
Does anybody have any idea why these young people have been afflicted with this disease.There is no cure and they have to live with cml the rest of their lives.We adapt to our cml it's not easy,but these are such young people just starting their lives.It's heartbreaking they are so scared.
Posted by Billie Murawski on April 21,2011 | 12:28 AM
I wish these stories would get to the point quicker. "A Triumph in the War Against Cancer" is a provocative title. I want to read and know the facts asap. But first I have to read about a (Betty Grable look alike sitting on a grave, blab, blab, blab). (The size of her spleen, blab, blab, blab.) (He reserves a U-haul to haul away her clothers, blab, blab, blab.
That type of story approach is great for a novel, but for serious articles promising critical information I say gets to the point. I'm very happy that the woman survived. I really am, but it's the what and how of the article that matters most in this story. After that if you want to tell us the human interest, then fine.
Posted by John Nienstedt on April 21,2011 | 07:31 PM
What a remarkable story for his patients as well as dogged perseverance on Dr. Drukers part. Goes to show us all that maybe conventional treatments as well as the ones who provide them can be dramatically improved with an open minded approach.
Posted by Richard Scaramelli on April 21,2011 | 05:32 PM


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Robert Pattinson: Career in pictures
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( Spencer Weiner / Los Angeles Times / August 16, 2012 )
By Emily Christianson, Whitney Friedlander and Lily Mihalik, Los Angeles Times
Robert Pattinson is one busy guy. Since landing the role of vampire Edward Cullen in the "Twilight" franchise, the 24-year-old seems to have done nothing but hone his craft. With his new movie "Water for Elephants" hitting theaters April 22, let's take a look at some of his more memorable projects so far. |
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text: North Raleigh's TREIA Sub Group meets monthly to discuss the Real Estate Investing World. Topics include: Rehabbing, Private Money Lending, Wholesaling, Seller Financing, Lease Options, Subject-To and other topics with an emphasis on the local market. Meet other investors, new and seasoned, interested in the Northern end of the triangle! ALL ARE WELCOME!


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text:
Commentary: Worst anti-biotech study ever
resize text | Tweet |
It seems that every so often an otherwise reputable journal prints a report or a study that directly counters the scientific consensus, but gee—it just happens to dovetail perfectly with some anti-industry screed one (or more) of the researchers secretly harbors.
Usually, the report contains some kernels of truth, a few nuggets of wisdom and at least a semblance of the scientific method.
However, a new study titled, "Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize" published in the Journal of Food and Chemical Toxicology, "does not follow universal standards for a scientific experiment," according to a statement released by the American Society of Animal Science Board of Directors.
That's putting it mildly.
Here's what the controversy's all about, as an excerpt from the actual study graphically depicts:
"The health effects of a Roundup-tolerant genetically modified maize (from 11% in the diet), cultivated with or without Roundup, and Roundup alone (from 0.1 ppb in water), were studied 2 years in rats," the authors wrote. "In females, all treated groups died 2 to 3 times more than controls, and more rapidly. This difference was visible in 3 male groups fed GMOs. All results were hormone- and sex-dependent, and the pathological profiles were comparable. Females developed large mammary tumors almost always more often than and before controls, the pituitary was the second most disabled organ; the sex hormonal balance was modified by GMO and Roundup treatments."
The writing isn't very elegant, but the conclusions are stark. If this research were credible, all of us who have been consuming genetically engineered corn, soy and other food ingredients for the last decade-plus would be in serious trouble.
Only one problem: The study is bunk.
In this study, the control group of rats was fed non-GM corn and Roundup-free water. Unfortunately, the control group had only 10 rats of each sex. Testing just 20 rats cannot generate statistically significant results.The researchers' conclusions are thus "based on a poorly designed experiment and unreliable statistics," according to the ASAS statement.
An expert in animal genomics and biotechnology was even harsher.o
"What's wrong with this study? I can't even count the ways," said Dr. Alison Van Eenennaam, a Cooperative Extension Specialist at the University of California-Davis. "The authors refused to share their data with other scientists, they didn't perform a statistical analysis of the data and the strain of rats they used is known to spontaneously develop tumors.


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Chantal Loison, Cirad, France
Scientific Director
François Cote, Cirad, France
Editorial Board
Fruits is a scientific journal for original articles and reviews on fruit crops in temperate, Mediterranean, subtropical and tropical regions. Fruits covers a wide range of subjects (agronomy, crop protection, postharvest storage, product processing and marketing). Considering the large number of manuscripts received currently by the Fruits Editorial Secretary, priorities had to be established. They are related to papers regarding Cultivation and crop management of underutilised fruit species, Integrated management of fruit pests and environmental risks and Fruit studies in relation with consumer's health. In each issue, the journal presents a list of forthcoming meetings and new books published on the fruit topic.


text:
"The Life And Times Of Prophecy"
Lookin Like 20-12 Is In Full Movaphu@kin affizekt..
Seems as though our Globe is expressin some None-too-Happiness at our current state and is deciding to let us know.
- Southern California has experienced not One, but Two Earthquakes ranging in the 4.4 / 4.5 range in just the last twelve hours. The first earthquake occurred last night at around 9:20pm on Tuesday, and almost exactly 12 hours later, the second earthquake occurred at around 9:20am. These temblors come exactly 2 weeks after a 3.8 Quake kickstarted this madness.
- New Zealand's Long Dormant Volcano, Mount Tongariro, erupted last night sending a plume of Smoke and Volcanic Ash 20,000 feet into the air, cancelling all domestic flights. This is the first eruption from this Volcano, which was the backdrop for The Lord Of The Rings Trilogy, in over 100 years.
- The First Half of 2012 is the Hottest First Half of a Year on Record for the United States since 1895.
- The Northeastern United States and the majority of the Midwest has experienced the Hottest year on record, also since 1895, for the period from August 2011 to July 2012, leading to the Greatest Drought in History currently covering over 63% of the United States.… Prompting the "President" to seek Government Assistance for Drought stricken Areas.
- July is the Hottest Month on Record since 1895
Looks like this world is getting a little Heated son. That with all these random acts of Global Violence and copy cat attempts, severe accounts of flooding throughout China and the Philippines, along with another event of thousands of fish washing up in the Midwest streams… it's lookin like we all need to start preparing for some intense times to come. It is no coincidence that all these events would happen simultaneously, both the natural events, along with these "seemingly random" acts of violence.
The first half of of the year has passed,
let's see what the next half will bring,
Be Braced In This World That's Spinnin Too Fast
How intense will these waves fully swing.
Garry "Prophecy" Sun for SunOfHollywood.com


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Suitable from 6 months+
Order in the next 4 hours 10 minutes for express home delivery on Monday
The Chicco Touch and Spin Highchair Toy is ideal for entertaining babies whilst they are in their highchair. The central section rotates by 360 degrees and the coloured balls make a noise as they move around inside the sphere. The plastic surface has different textures to develop little ones tactile skills.
This toy is simple but it's great for my teething son. It comes off quite easily but this is just part of the game with my son.
Product does entertain my 8 month old lots when in her highchair but doesnt stick amazingly well.
Brillient toy keeps my little boy amused for ages but either he is too strong or the sucker isnt strong enough as he can pull it off the tray and he's only 9 months old
This entertaining toy will keep your child happy and smiling while they are in their highchair waiting for you. Rotating 360 degrees means that they can explore the whole toy. Strong Suction Pads means that it will stay in place and it wont easily tip over frustrating your child.
These are exclusive customer reviews unless otherwise stated. Specifications of goods are subject to change.
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This product is available as a pre-order. This means that we do not currently have the item in stock but we are expecting it shortly. You can place an order for this product now your expected shipping date will be 19-12-2013
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text: What's Hot 2013 Gift Ideas Remembering Mandela World Cup Draw GALLERIES Jennifer Coolidge Pics 0 11 Back to Top ▲ Jennifer Coolidge Pics Jennifer Coolidge Pics AskMen Editors Anyone familiar with the American Pie franchise will instantly recognize Jennifer Coolidge as Stifler's Mom, the object of desire for the love-starved Finch. Jennifer has had a string of roles in Christopher Guest's mockumentaries, a recurring part on Joey and a memorable guest spot on Seinfeld as Jerry's somewhat frigid masseuse girlfriend. She also had a juicy supporting role in Reese... Continue reading Jennifer Coolidge's profile. Next Page Exclusive Access Get the best deals for men on Black Friday, Cyber Monday & more ✓ You're in!We'll be in touch soon. ✗ Something went wrong.Try again later. Subscribing to a newsletter indicates your consent to our Terms of Use and Privacy Policy.


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Tax attorneys, practitioners (litigation and transactional) in other areas where international tax issues are a concern, and academics will all appreciate Intertax's authoritative, reliable content and numerous useful features. Intertax also includes subscription to EC Tax Review .
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American Art Broom Made in Mount Lebanon, New York, United States, North and Central AmericaLate 18th century Robert Valentine, American (Shaker), 1822 - 1910. Made by Mount Lebanon Community, New Lebanon, New York, organized 1787, disbanded 1947. Broom made from corn; wooden handle * Gallery 113, American Art, first floor (Newman Gallery) 1963-160-93 Gift of Mr. and Mrs. Julius Zieget, 1963 |
* Works in the collection are moved off view for many different reasons. Although gallery locations on the website are updated regularly, there is no guarantee that this object will be on display on the day of your visit. |


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- Ease of use
- After sales service
- Value for money
JASCO has introduced the latest version of their Spectra Manager vendor-specific, cross-platform software package for controlling a complete range of spectroscopic instrumentation including FT/IR, UV/Vis/NIR, Fluorescence, Raman, and CD.
This spectral analysis program offers a comprehensive package for capturing and processing data. A single computer can collect data simultaneously from several complimentary techniques.
The new Spectra Manager II™ features enhanced audit trails, an optimized FT-IR instrument interface, streamlined user interaction for instrument control plus enhancements to Canvas report templates and improved processing command functions. For 21 CFR Part 11 compliance JASCO offers Spectra Manager CFR, a security enhanced software with data tracking and audit capabilities.
Emily Beckelhimer Status: See all reviews Member since 2011 Organization: Marshall University Read more » | 2.6 RATING:
"Could not find the 'help' function, so trouble shooting was difficult. When we had problems it was difficult to find someone at the company who could help us." |
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text:
Recensito da un utente di Hotels.com in data 17 set 2012
L'ospite non ha lasciato commenti.
"facile da raggiungere"Recensito da un utente di Hotels.com in data 11 set 2012
buon rapporto qualità prezzo
""Recensito da un utente di Hotels.com in data 7 set 2012
Stanze più che decenti, buon rapporto qualità prezzo
Recensito da un utente di Hotels.com in data 24 ago 2012
L'ospite non ha lasciato commenti.
"Motel a MorroBay"Recensito da un utente di Hotels.com in data 6 ago 2012
Nel complesso molto buono, colazione non esagerata ma piuttosto essenziale.Da tenere in considerazione.
Per eventuali ospiti aggiuntivi possono essere previsti supplementi, variabili in base alla politica dell'hotel.
All'arrivo vengono richiesti un documento di identità comprensivo di fotografia e una carta di credito per eventuali spese accessorie.
Tutte le richieste speciali sono soggette a disponibilità al momento dell'arrivo e possono comportare spese aggiuntive. Le richieste speciali non sono garantite.
**Questi servizi potrebbero essere disponibili solamente in alcune camere o in alcuni alloggi. Alcuni servizi potrebbero comportare un supplemento.
Le tariffe e cauzioni seguenti sono addebitate dalla struttura al momento dell'erogazione del servizio, all'arrivo o alla partenza.
È possibile che questo elenco non sia completo. Tariffe e cauzioni potrebbero non includere le tasse e sono soggette a modifiche.
Per eventuali ospiti aggiuntivi possono essere previsti supplementi, variabili in base alla politica dell'hotel.
All'arrivo vengono richiesti un documento di identità comprensivo di fotografia e una carta di credito per eventuali spese accessorie.
Tutte le richieste speciali sono soggette a disponibilità al momento dell'arrivo e possono comportare spese aggiuntive. Le richieste speciali non sono garantite.
"Very good for the price; excellent location."
This cozy motel was a great surprise. The room could be cleaner, yes, but it was perfect for what we were looking for. The staff is nice and authentic. I recommend it!Recensioni obiettive Hotels.com
"Basic. Clean. Friendly."
This is a very basic room in a beach town. It was very clean. Had strong WiFi and a friendly helpful staff. Located about a half mile from the pier and downtown area.Recensioni obiettive Hotels.com
"Only stay here if you want a cheap motel."
The heater didnt work, there were no extra blankets, the door had no seal you could see light come through the edges of the door and also feel the cold air. The tv was terrible, the bed had hair in it. It's amazing what they chose to remodel and what the chose to ignore. Seriously, only stay here if you can't afford anything else.Recensioni obiettive Hotels.com
I have always liked how quaint the Palomar Inn is. The rooms are clean and functional. Not really a vacation destination hotel but the area beautiful and the hotel is conveniently located to my family. The owners are gracious and accommodating. I will stay there any time I am in the area.Recensioni obiettive Hotels.com
"Spartan, small, adequate"
Their service (check-in) was very friendly. But room was tiny, and parking lot noise intrusive. My heat didn't work, which is an issue for at least 6 months of the year here. I didn't complain, because it was so late when I got in, I decided to tough it out. On the plus side, the coffee shop next door (non-affiliated) was quite lovely, and open at 6 […] am! Had a nice run to the west, cuz staying in the room was out of the question! Only 3-4 channels on the TV! This place offers the bare minimum accommodations, but the bed was comfy enough, the rate was cheap, and as I said, friendly staff. Continua a leggereRecensioni obiettive Hotels.com
"Needs a ton of work."
Bathroom was DIRTY. Stains on bedspread and carpet.Recensioni obiettive Hotels.com
"Cute clean dive, but..."
Going to wedding and only staying one night, so weren't going to spend any time in room but for changing & sleeping, so got a this cheap hotel in good location. Everything fine, clean, vintagey...super small, but super nice staff. However bed was ROCK HARD. Awake all night, wondering how a matteress could possibly be so hard, could it actually just […] be a big plank of wood? Morning light showed it looked like a mattress, but still I'm not convinced it wasn't just a wrapped pool table. If you get a good deal, stay there, but ask for a room with updated mattress or bring a pad to put on the bed. Continua a leggereRecensioni obiettive Hotels.com
"Excellent Value"
I was on a motorcycle trip and needed a place to stay as it getting near dark. I chose the Palomar because of the price but was pleasantly surprised at the value I got. The room was small but that didn't matter to me as I was travelling alone. The room was extremely clean and the bed was comfortable.....that's all I needed. Would stay there again and […] I recommend it. Continua a leggereRecensioni obiettive Hotels.com
"convenient location"
Nothing fancy here but comfortable, clean and convenient. Friendly staff.Recensioni obiettive Hotels.com
"◄ Best Bang for the Money! ►"
I read a number of negative reviews prior to making my reservation. I based my decision on the fact that for every negative review there were far more positive reviews. Yes, the Palomar Inn is old. Yes, the rooms are small, but the room I had was clean and very well maintained. The room has a microwave and small refrigerator, standard TV and drum roll […] ... a VCR. Seriously, for the money you can not do better. Every other hotel in the area charges $30 to $150 more per night. Keep in mind this hotel/motel was built decades ago so it is not on par with a four star establishment that you will find close by. But again, it is clean and well maintain and I will stay at the Palomar Inn when I next visit the central coast. Continua a leggereRecensioni obiettive Hotels.com
"Beautiful neighborhood/dirty room"
I love the fact that it was within walking distance ocean view and the surrounding neighborhood was beauty. However, Palomar Inn's description was misleading. The bed was hard, bedspread had stains and cigarette burns. The carpet was nasty dirty. It was obvious the maid had not cleaned /vacuum along the walls or corners of the room. It was absolutely […] dusty and dirty. Continua a leggereRecensioni obiettive Hotels.com
"Very small room but clean. A cabin feel."
It was very quiet and it was clean, but very small room. It did the job for a night stay.Recensioni obiettive Hotels.com
"great location"
Was ok for a night stay..Recensioni obiettive Hotels.com
"bargain hotel near the beach"
Get there earlier than 10 on a friday if you want a hot shower. The Palomar is a decent, cheap place to stay in Shell Beach. Out of date, slightly sketchy, but pet friendly and clean. Microwave and fridge greatly appreciated by the budget traveler.Recensioni obiettive degli ospiti Expedia
"Don't stay here"
Booked the hotel for the quite yet convient location, however, found the room to be pretty dirty with dust everywhere. I would have been better off at a Motel 6!Recensioni obiettive Hotels.com
"An oldie, but a goodie"
If you can't afford to stay right on the beach, this motel will suffice. Rooms are very small, but they have what you need: bathroom, bed, micro and fridge. Nothing fancy, nothing new, but it was clean and quiet. Very close to Zorro's, which was a great little Mexican food restaurant!! loved it!Recensioni obiettive Hotels.com
"Enjoyed my stay."
Had a very nice time. Enjoyed walking down to the beach and looking at the beautiful homes. The weather was great.Recensioni obiettive degli ospiti Expedia
"You get what you pay for."
We booked at the last minute while traveling down the central coast. Inexpensive, clean, but very outdated. Good location Shell Beach, but a lot of highway noise. Staff was nice. Did I say inexpensive and last minute?Recensioni obiettive degli ospiti Expedia
"Run down and cramped"
But half the price of nearby motels that probably aren't any better.Recensioni obiettive Hotels.com
"Quaint place minutes from beach"
The Palomar in wasn't bad for the price. Rooms were small, clean, and reminded me of grandmas. It is blocks away from little hikes to beach and the surrounding area is that of a beach community. The one complaint I would have would be the bed being so uncomfortable. It was hard as a rock and both of us woke up with back pain. Other than that our stay […] was pleasant for the price, and location. Continua a leggereRecensioni obiettive Hotels.com
"Teeny tiny, but served the purpose"
We booked this hotel knowing we would spend minimal time in it. Since the other options in the area were $300+ we figured we would be getting what we paid for--a tiny room and bathroom, and not very comfortable bed. I think it was fine for my husband and me, but would not return with kids. Parking was great! The coffee shop next door, the Steaming Bean, […] was adorable and had excellent coffee (in fact, the coffee shop was the best part of the hotel). Continua a leggereRecensioni obiettive degli ospiti Expedia
"cute little place"
It was late and we were tired...looked up hotels.com. the hotel we looked ay was full and The Palomar Inn was recommended. Cute, vintage motel. Very nice staff considering we showed up at 11:45pm. Room was full of mismatched but it was very clean and it had a full kitchen. Only complaint was the fan in the bathroom was extremely loud. Let them know […] in the morning and I am sure it is fixed by now. They also were great at recommending local restaurant Zorro's for breakfast. Continua a leggereRecensioni obiettive Hotels.com
"One of the Hotel with Worst Service"
The old chinese man at the front desk was very rude. He made it clear that it was our fault that we did not understand him. We did not know what he was saying because of his accent, yet he was impatient with us. Several electrical outlets did not work. TV was old and difficult to operate.Recensioni obiettive Hotels.com
"Charming little hotel. Close to food and beach"
Stayed 2 nights and the staff was very helpful in making our stay great. There's a great coffee shop right next to the hotel which is delicious. We walked to the beach. There's also a big park for kids about 1 mile from the hotelRecensioni obiettive degli ospiti Expedia
"not as bad as everyone says"
The stay wasnt so bad. The only bad thing was it was hot and the fan didnt work. The bed was comfy and the hotel was really quiet.Recensioni obiettive Hotels.com
"Vintage charmer - close to everything"
Our stay was convenient and the staff was very nice. Our out of state neighbor was up all night making noise - which was the only down side. The room was pretty small, but nicely maintained over all.Recensioni obiettive Hotels.com
"Nice room"
The room was nice. Beach nearby.Recensioni obiettive Hotels.com
"Last minute booking"
Not as close to shopping or beach as I wanted. Bathroom was tiny, shower stall felt cramped. I didn't want to pay a lot just for the night, so it was adequate. The front desk lady was nice. Was able to use the WiFi, it had a fridge & microwave, that's a plus.Recensioni obiettive degli ospiti Expedia
"Convenient Quaint place"
this is a great no frills stay...It meets the basic needs and is comfortable as you travel on the 101 highway and need a place to lay your head for the night. Great location for a walk to the beach in the morning or to grab a bite to eat at a near by restaurant. The hosts are cordial and pleasant.Recensioni obiettive Hotels.com
old hotel, nice reception, NOT a two starRecensioni obiettive Hotels.com
"Nice little spot to relax"
Definitely the smallest hotel room I've ever stayed in but it was perfect for two. Very clean, the lady at the front desk was such a sweetheart! The only bad thing was no AC just heat and a ceiling fan but when you open the windows it was totally do-able. I would definitely go back!Recensioni obiettive Hotels.com
"5 stars for the price!"
This was a small, older motel. The rooms were very small and not fancy. But it also was only $53 a night. VERY clean. We were tired and dudnt feel like driving the final 4 hours home and we didnt want to spend a lot of money. this was just fine. i wasnt expecting the Hilton for this price. The best part was the 3 minute walk to the beach and the great […] coffee shop/cafe next door. We will stay here again. By the way, we are professional who can afford to pay more, but we usually don't for only one night. This was a good deal for being so close to the ocean and very clean. If you want fancy and large, don't go here! Continua a leggereRecensioni obiettive Hotels.com
"Great hotel traveling thru or looking for value"
Nice boutique little hotel (same with the rooms) nothing fancy, but in a great neighborhood with plenty of cafe's, restaurants and bars within walking distance. Beaches are nearby. Just a good value for a couple of days. You want something more upscale, $$$ buys you that upgrade just a mile to the north/south of this hotel.Recensioni obiettive degli ospiti Expedia
"Small, but comfy"
Nice motel, with small rooms, but all the amenities, like a fridge, microwave and WiFi. Friendly staff too.Recensioni obiettive Hotels.com
"Not a great place to stay"
The room was very unpleasant and didn't seem very clean. The hot water wouldn't come on in the shower, and when my husband asked the manager, he said, "wait another twenty minutes and if it's still not working, come and get me." The bed was uncomfortable and I felt on edge during the duration of the stay because the motel was creepy. At least the doors […] locked. I wouldn't recommend this place to anyone, but what can you expect from a cheap motel... Continua a leggereRecensioni obiettive degli ospiti Expedia
It was fine for the price. You get what you pay for.Recensioni obiettive Hotels.com
Had a lovely time...walls are very thin however & we had noisy neighbors that we had to call at 11pm. Perhaps when people check in, they could remind people to be conscious about of nouse levels after 10 pm.Recensioni obiettive Hotels.com
Convenient location. Friendly thoughtful staff. Small room but cozy with all amenities privided.Recensioni obiettive Hotels.com
"Great location, quite neighborhood, walk to beach"
Great place to stay in a classic southern California beach town. Clean, comfortable rooms and very friendly staff. This is a much better option than the chain hotels in the area. I would definitely return.Recensioni obiettive Hotels.com
"Palomar stay"
Surprisingly good! Room was clean Great independent coffee house next door, Basque eatery. on the other side. Great stay for the price!Recensioni obiettive Hotels.com
"There are better places to stay in the area"
The hotel was alright, but room was pretty small and the location a bit out of the way from restaurants etc. There are better places to stay in Pismo beachRecensioni obiettive Hotels.com
"Amazing deal for the quality & location!"
Was on my way from San Diego -> San Francisco, and spent a night at the Palomar. Very friendly front desk staff! Wonderful little eateries walking distance. Close to the beach & freeway. Room was much nicer than anticipated, very clean! Easy parking. Heater was a bit old, but other than that, this hotel was perfect! And CHEAP!Recensioni obiettive Hotels.com
I was only there for business but did want to spend time on the beach. On the same street, I found a beautiful secluded park right of the beach with stairs going down to the shore. It was beatiful, don't let the area scare you away.Recensioni obiettive Hotels.com
"simple room, great location"
Pros- walking distance to the beach and coffee shop through a very nice neighborhood. Nice locals. Very dog friendly community. Right in the middle of pismo and avila beach. Nice staff. Cons- small cramped room, barely any amenities. Just a simple room which is fine if u don't plan on spending to much time in it. Overall we had a great time being […] so close to everything. Continua a leggereRecensioni obiettive Hotels.com
"definitely not like the pictures"
Our room looked nothing like the pictures posted here on expedia. Our room was tiny, bathroom so tiny you could wash your hands while sitting on the toilet. There was no kitchen type area, just a small, loud refrigeration with a microwave on top next to the door and everything was so outdated. A little dirty too. I know the rooms were cheap, but if […] I would have seen the pictured of the room we were given, I would have booked it, no matter how cheap. Continua a leggereRecensioni obiettive Hotels.com
"No hot water, uncomfortable bed"
I knew when I made this reservation that the rooms would be small; The Palomar Inn is clearly a "mom 'n pop" type of establishment. That being said, the room was REALLY small (barely enough room to walk between the bed and the wall), the "queen" size bed felt like it was made of cardboard, and when I got up early Saturday morning and tried to shower, […] there was NO HOT WATER (despite letting it run for 10 or so minutes). We ended up leaving a night early and sacrificing the money we had paid for our second night. All of the negatives aside, however, the woman at the desk was very friendly. Continua a leggereRecensioni obiettive Hotels.com
I loved the location. The bed was very firm and the tv remote didn't work, but the room was well laid out and the motel was charming! The room seemed very clean. You could tell it had some updates done recently.Recensioni obiettive Hotels.com
The rooms are small but who stays inside when your on vacation? We stayed there a second night on our way home, so what does that tell you? Quiet place and the manager/owner was very nice person. Very glad I supported the small business owner.Recensioni obiettive Hotels.com
"Quaint and convenient"
I was in for a wedding in Pismo beach. There is a great coffee/breakfast place in front of the hotel that was gerat. This is not the fanciest hotel in the area and has no view but it is an affordable option I'm glad I used.Recensioni obiettive Hotels.com
"scam dont book"
It's not what they show on photos and clerk knew about it..please don't book with them.Recensioni obiettive Hotels.com
Le recensioni e i punteggi presenti su questo sito riflettono opinioni soggettive dei clienti e dei fornitori e non implicano il consenso di Hotels.com. Né Hotels.com, né le parti coinvolte nella stesura delle recensioni possono essere ritenute responsabili di eventuali danni derivanti da qualsiasi uso si faccia di dette recensioni.


text:
Mr. HEFFREN moved that the special order-the bill [H. R. 247]-for the incorporation of towns, etc., be taken up.
Mr. JEWETT opposed the motion to take up the special order. He felt that many members voted under a mistaken impression yesterday when they voted to pass over the consideration of the bill [H. R. 26] concerning promissory notes, bills of exchange, etc., and he believed that two-thirds of the members of the House desired to pass the bill. The bill has been before the House three times, and had each time been set aside. He thought that the motion for the special order should be voted down.
Messrs. Patten, Gordon and Copeland spoke in favor of taking up the special order.
The bill was taken up and read and the SPEAKER announced that it was ready for amendment.
Mr. BEST and Mr. SHOCKNEY each offered amendments.


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Belgian Roll Arm Upholstered Left-Arm Sofa Chaise Sectional
Our European-inspired take on the classic sofa redefines it for a new age. Low to the ground, deep in profile, and sleekly streamlined for sophisticated appeal, it's a chic, ultra-comfortable twist on tradition.
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- 96" Classic Left-Arm Sofa Chaise Sectional: 96"W x 73"D x 32"H
- 115" Luxe Left-Arm Sofa Chaise Sectional: 115"W x 80"D x 35"H
- Clearance needed for delivery: 33". Learn more.
Shown in sand Belgian Linen.
Belgian Roll Arm Upholstered Left-Arm Sofa Chaise Sectional
Belgian Roll Arm Upholstered Right-Arm Sofa Chaise Sectional


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Spotlight: Member Stories
I love to write press releases, blogs or indulge myself to social networking. The paragraph below are just example of what I usually do when boredom k...More
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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.


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Love the keynotes? This updated classic square toe dress style is lightweight and has a cushioned insole for added comfort. Perfect from desk to dinner! Elevated by a 1 1/2" heel. Available in medium and wide. **The Oro runs narrow, please size down in width when ordering.**
1 1/2" Heel
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Style Code: ESORO


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- Nelson Mandela's Most Inspiring Quotes
- Weird & Wonderful Pictures Of The Week
- Kate And Will On The Red Carpet
- Sleeps 'Til Santa - Audio
- Sledge Mama
Nelson Mandela's Most Inspiring Quotes
Words of wisdom from the late, great Nelson Mandela.
Weird & Wonderful Pictures Of The Week
Festive fish and Victoria Beckham's wedding tiara: take a look at this week's most amazing photos.
Kate And Will On The Red Carpet
The Duke and the Duchess of Cambridge attended the 'Mandela: Long Walk To Freedom' premiere.
Sleeps 'Til Santa - Audio Audio
Join us in our musical countdown to Christmas Day!
Sledge Mama
Vote For The Best Of 2013
Heart's Sexiest Female Of 2013 - Vote
Heart's Best Single Of 2013 - Vote
Heart's Best Celebrity Couple Of 2013 - Vote
News & Pictures
Gallery Nigella Lawson: 40 Hottest Pictures
She's the ultimate domestic goddess, the queen of curves, and as glam as ever at 53. See her sexiest moments.
Gallery Celebrities Without Makeup: Stars Go Natural!
Emma Watson, Kate Moss and Holly Willoughby ditch the make-up. See the pictures to believe it!
Celebrity News & Pictures
- Tom Daley: 20 Hottest Pictures Of The Olympic Star
- Best Celebrity Pictures Of The Week - 2 December 2013
- Nelson Mandela Dies: World Leaders' Reactions And Tributes
- Nelson Mandela's Most Inspiring Quotes
- Weird & Wonderful Pictures Of The Week - 6 December 2013
- Jamie Dornan: 20 Sexiest Pictures Of The Christian Grey Actor
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Make it a musical festive season, enter to win a fabulous £1,000 to spend at Musicroom.
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Check Out Olly Murs In Our New TV Ad
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For you fans of The Walking Dead....
The Cotard delusion, Cotards syndrome, or Walking Corpse Syndrome is a rare mental disorder in which people hold a delusional belief that they are dead (either figuratively or literally), do not exist, are putrefying, or have lost their blood or internal organs. In rare instances, it can include delusions of immortality.
The syndrome is named after Jules Cotard (18401889), a French neurologist who first described the condition, which he called le délire de négation (negation delirium), in a lecture in Paris in 1880. He described the syndrome as having degrees of severity that range from mild to severe. Despair and self-loathing characterize a mild state. Severe state is characterized by intense delusions and chronic depression.
In one of his lectures, Cotard described a patient with the pseudonym of Mademoiselle X, who denied the existence of several parts of her body and her need to eat. Later she believed she was eternally damned and could no longer die a natural death. She later died of starvation.
Cotards syndrome has been found to have three distinct stages. In the first stage, Germination, patients exhibit psychotic depression and hypochondriacal symptoms. The second stage, Blooming, is characterized by the full blown development of the syndrome and the delusions of negation. The third stage, Chronic, is characterized by severe delusions and chronic depression.
People with the Cotard Delusion often become withdrawn from others and they tend to neglect their own hygiene and well-being. The delusion makes it impossible for patients to make sense of reality, which results in an extremely distorted view of the world. This delusion is often found in psychotic patients suffering from schizophrenia. While Cotards Syndrome doesnt necessitate hallucinations, the strong delusions are comparable to those found in schizophrenic patients.
Yes, but the technology is very new. It will probably be a while before it becomes standard treatment. Here is some more info if interested:
Take a minute to watch a deaf baby hear for the very first time with a cochlear implant. Amazing!
That will make me cry, Peachy!
New Band-Aid technology
AmoeBAND became a 2012 IDEA Award Finalist by innovating every possible aspect of the plaster (band aid).
The design revisions were:
- Strategic cut-outs shape to fit fingers in such a way that it is easy to bend them and not disrupt the bandage.
- An intelligent dressing material allows you to regularly check wounds from the outside, without upsetting the healing process.According to research, the when an infection of a wound is detected, the pH value is between 6.5 and 8.5. AmoeBANDs indicator cross turns purple, alerting the user needs to change it immediately.
- Since the bandage material used exudes a leather-like feel,availability in different skin-tones helps it blend in, without overly highlighting the injury.
- The packaging has been redesigned to a matchbox style and includes Braille instructions.
Hi Pony
good thread peachy. I will try to post some xrays tmw of my shoulders after a car accident.
I've got a few bio textbooks lying around
I might upload a few pics tomorrow
Lewandowsky-Lutz dysplasia is a very rare skin disease involving a genetic susceptibility to the human papillomaviru. Scaly macules (flat pigmented skin lesion) and skin bumps develop on the skin, especially on the back of the hands. The condition carries an increased risk of skin cancer, especially in sun-exposed parts of the body such as the back of the hands. The warty growths can become very extensive and surgery may be needed to remove them.


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Northwest Sports Update
A sportsbook review of the Seattle Seahawks' camp so far may focus on the battle at quarterback, where Matt Flynn, Tarvaris Jackson and rookie Russell Wilson are reportedly all still in contention to start as they get ready for the preseason. Whichever quarterback manages to win the battle should have a potentially dangerous group of receivers to work with.
Sidney Rice is the most talented receiver in Seattle and sports betting players will remember him from an explosive time in Minnesota, when he was a favorite target of Brett Favre, but Rice has since struggled with injuries and has played just 15 games in the last two seasons, including nine last season. Rice may not even play in the preseason as he had concussion and shoulder problems and the Seahawks want him to be as healthy as possible for the regular season.
The Seahawks also brought in a couple of names that may be familiar to sport betting players as Braylon Edwards has been given a chance to spark his career again, and Kellen Winslow will split time with Zach Miller at tight end. Edwards played just nine games with San Francisco before the two went their separate ways, and when he is on, Edwards can be electrifying, even if he has had issues with drops in the past. As for Winslow, he has been bothered by his knees for years now, but he can still be effective over the middle for the Seahawks and along with Miller, Seattle could have quite a duo at tight end. They also brought in Antonio Bryant, but he was expectedly out of shape after being out of the game since 2009.
NCAA football betting (find more NCAA football betting odds here) fans will remember that Golden Tate was highly touted coming out of Notre Dame and in his third season in the NFL, he is expected to take a big leap in his development, and right now he is being penciled in as the No.2 receiver. Tate had to miss OTAs because of a broken hand, but he is fully healthy and ready to put his stamp on the team. The Seahawks need him to step because while Doug Baldwin (who should start in the slot if the Seahawks go to a three-receiver set fulltime) and Ben Obomanu are solid slot-receiver types, they're out of their element at starters in a normal set and Tate has too much talent to not be a starter in the NFL.
There are a lot of ifs surrounding the Seattle receivers, with health and general inconsistency as the main issues, but if they can manage to pull it together, the Seahawk receivers could have a real effect on their team's NFL betting odds.


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Packers Young Secondary Can Erase Bad Memories of Playoff Hail Mary
I know your belly is still full of Thanksgiving turkey and you're probably all excited that you managed to outlast the middled-aged lady next to you for that discounted Xbox at Wal-Mart on Black Friday.
If you can overcome your full stomach and pause your Xbox euphoria, take a minute and watch the video of the Packers allowing a Hail Mary touchdown to the Giants' Hakeem Nicks before halftime in last season's playoff loss.
Makes your full tummy feel more like the stomach flu, right?
Now, take another look at the play. Notice the four players around the ball when Nicks comes down with it? Not one of them will be on the field for this Sunday night's rematch.
Charlie Peprah is off the team. Charles Woodson is injured. Sam Shields is injured. And Jarrett Bush mainly plays special teams (I suppose it's conceiveable that Bush could end up out there, but hopefully not).
If Eli Manning launches another Hail Mary on Sunday, the players around the ball will likely be a combination of Tramon Williams, Casey Hayward, Davon House, Morgan Burnett, Jerron McMillian and M.D. Jennings.
That group is a lot more aggressive than the group that stood there with their thumbs up their butts while Nix caught the ball in the playoffs.
Hell, Jennings has already intercepted a Hail Mary pass this season, even though it counted as a touchdown for the other team.


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The students were told all four memories were real and had been supplied by their family member. After receiving the packet, the students identified whether they remembered each event and how confident they were that it had happened to them. In follow-up interviews the researchers asked them to recall details from the events they remembered.
Seven of the 24 students "remembered" the false event in their packets. Several recalled and added their own details to the memory.
"It was pretty exciting to watch these normal, healthy individuals pick up on the suggestions in our interviews, and pick up the false information that we fed them," Loftus says.
Loftus continued her experiments, convincing study participants they had broken a window with their hand, witnessed a drug bust, choked on an object before the age of 3 and had experienced other traumatic events. And she continued to testify in cases involving repressed memories.
"I don't think there's any credible, scientific support for this notion of massive repression," Loftus says. "It's been my position that, you know, we may one day find (the evidence), but until we do, we shouldn't be locking people up."
Unhealthy habits
Loftus soon began to wonder if she could influence other behaviors. What if she could convince people they had a negative experience with unhealthy food as a child? Would they eat less of it as an adult?
Using her finely tuned "recipe" for memory implantation, she guided study participants to believe they had gotten sick eating strawberry ice cream as children.
A week later, researchers asked about the ice cream incident. Many participants had developed a detailed memory -- what Loftus calls a "rich false memory" -- about when they had gotten sick. Subsequent studies showed this memory affected the participant's actual eating behavior.
It seemed obvious to Loftus that there was potential here to fight obesity. Therapists couldn't lie to their patients, but parents could convince kids that they didn't like ice cream or other fattening foods. Critics raged that she was advocating lying to children.
"Which would you rather have?" Loftus replied simply. "A kid with obesity, heart problems, shortened lifespan, diabetes -- or maybe a little bit of false memory?"
Schacter, who also studies memory, objects to the term "playing around" with someone's mind. He, Loftus and others like them are simply trying to understand what's going on in our memories, he says. "We're assessing the limits of memory, the accuracy of memory. ... Almost by definition we think we're remembering accurately, even though we're not."
Already this year Loftus has co-authored studies on false memories related to alcohol, politics and stressful events. In one, called "Queasy Does It," Loftus' team took the same methods they used to persuade people to eat less ice cream and applied them to vodka or rum. Loftus says this research could potentially be used to help addicts in the future.
Her lab at the University of California Irvine is also working to identify the individual differences that make people more or less susceptible to memory alteration.
Sometime Loftus worries about crossing into unethical territory -- like when she created false memories in military personnel who were training to survive as prisoners of war. When the study published, she feared "we were going to basically be giving (our enemies) a recipe for how to do bad things to other people and then contaminate their memory."
But as a scientist, she says sharing how to implant memories -- so we can potentially learn how to protect against it -- is better than burying the information.
Walking the line
In 2006, Loftus attended a talk by legal scholar Adam Kolber on the legal and ethical implications of memory-dampening drugs. According to Kolber, neuroscientists had made significant strides in creating medications victims could take after a traumatic event to dampen the intensity of their memories. Kolber contended that while those drugs could hamper legal proceedings, "We have a deeply personal interest in controlling our own minds that entitles us to a certain freedom of memory."
Loftus was fascinated. "I thought to myself, 'I would want (the drugs),'" she says. Her colleague disagreed. So like any good experimental psychologist, Loftus started a study.
She asked people if they were the victim of a vicious crime, would they want to take the drug? Eighty percent said no. Well, maybe they want to be able to testify against the perpetrator, Loftus thought. So she ran it again -- this time asking if they would take the drug after seeing their military buddy blown up by an IED overseas. Eighty percent refused.
"I thought, maybe I need to explain to them just how bad post-traumatic stress disorder is," she remembers. So she did. "And they still don't want the drug."
The results taught Loftus just how much people cherish their memories.
"Even if it's going to be a harmful memory, they don't want to let it go," she says. "(This is) why sometimes I get such resistance to the work I do. Because it's telling people that your mind might be full of much more fiction than you realize. And people don't like that."
But you don't need a psychological researcher to distort your memory in a lab, Loftus says. People distort their own memories all the time -- they remember getting better grades than they did, voting in more elections than they did, having kids that walked or talked earlier than they actually did. Loftus calls this "prestige-enhancing memories."
We all want to remember ourselves as just a little bit better than we really are, Loftus says, and that's not necessarily a bad thing. Scientists call it "depressive realism," and say depressed people may just remember things more accurately than the rest of us.


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SOURCE Xpanxion
ORLANDO, Fla., Sept. 30, 2013 /PRNewswire/ -- Xpanxion, a leading provider of global software solutions, was on site last week at the Gartner Outsourcing and Strategic Partnerships Summit in Orlando, Florida.
The Summit focused on how to effectively align sourcing to balance value, cost and risk. Chief information officers, sourcing executives and leaders were emboldened to convert innovative approaches into successful outcomes amid economic turbulence and fast-evolving technology change.
Xpanxion was part of the Rural Sourcing Pavilion, a Gartner spotlight on the growing market of rural sourcing providers. Rural sourcing refers to the outsourcing of technology work to non-urban locations, often in the Midwest where lower cost of living structures can be leveraged while maintaining the high quality of domestic work output. Xpanxion's "Cross-sourcing" model, however, goes above and beyond basic pure-play rural sourcing, combining rural resources, offshore resources, crowd-sourcing resources, and onsite resources to enable clients to achieve a best-of-breed (or blended) solution. This innovative model allows Xpanxion's clients to take advantage of the cost effectiveness of an offshore team with minimal risk and few disadvantages. Xpanxion attended the Gartner conference event to exhibit the unique model among industry leaders.
Distinguished Gartner analyst Allie Young presented on the topic of rural sourcing with the session, "Rural and Low Cost Domestic Sourcing: The Offshore Alternative". The discussion highlighted the rural sourcing movement, the benefits of "going rural", and situations in which a company should consider including a rural approach.
"As one of the pioneers of the rural sourcing business model, Xpanxion has journeyed down a path parallel to that of the global rural sourcing movement," says founder and CEO Paul Eurek. "This journey is at a dynamic point as rural sourcing – a young practice in the world of outsourcing – is being refined, improved, and transformed into a sustainable sourcing model."
To learn more about Gartner Summit events, visit www.gartner.com.
About Xpanxion, LLC
Xpanxion, LLC, provides software development, testing, and consulting services through an integrated rural and offshore sourcing model. This strategy utilizes the work ethic and quality of professionals in rural areas and the cost-effectiveness of resources overseas, enabling our clients to operate more efficiently, bring new products to market quickly, and ultimately achieve quality, cost, and business objectives.
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A Science Fiction Adventurer RP, which takes place in the same universe as my Achenaran Imperium and also coexists alongside modern Earth.
The year on Earth is 2011 CE, but no one cares about that, because humans are an underdeveloped race that lacks even the most basic of interstellar space travel.
Instead, the races of the galaxy refer to the year as Galactic Standard Year 1011, as it has been approximately 1011 years since the mysterious Promethean race vanished from the galaxy. Over the course of the last thousand years or so, various alien species have developed and perfected faster-than-light star travel, allowing them to traverse the stars as if crossing an ocean back in the Age of Sail. Empires have risen and fallen. From one of the greatest of these nations, a man retired from military service, using his pension to finance a spaceship to call his own.
This spaceship eventually because a privateer cruiser, taking contracts to exterminate pirates, deliver high-value goods, and perform all manner of tasks, so long as they paid well. He made a good living, for a time, and had fun.
Until his cruiser was taken away from him, his license stripped.
Sir James Drake, Achenaran Corsair. That's what he calls himself, now. He was no longer a licensed privateer, but he was at least able to obtain a Writ of Course, an interim license that allowed him to use destroyer he had obtained from the pirate clan of Jack Jaimeson to perform a serious of mission... mission that could lead to his re-acquisition of the license that had been unjustly taken from him.
But a Corsair needs a crew, of qualified individuals willing to take on high-risk mission for substantial pay. His last crew had been lost in an unfortunate battle. Now, as he recovers on the Surian outpost of Vegalia, in the chaotic territory that had once been the Zikaren Empire, James Drake is looking for these qualified individuals to fill the seats of his new crew.
Current crew positions
Navigator / Executive Officer:
Computer OS: Lisa Drake
Copilot: Open
Communications: Open
Sensors Operator: Open
Cyber Warfare:
Countermeasures: Open
Stealth systems:
Main guns (6):
5 open slots
Point defense turrets (55): 55 open slots
Ship's Doctor / Medic:
Service: Open
Chief Engineer: Open
Engineer tech (biotech): open
Engineer tech (power plant):
Engineer tech (warp drive): Open
Security personnel: Open slots
Always open slots.
Unrecruited/unassigned characters:
- - - Updated - - -
Here's the commander of the Vengeance:
Name: Sir James Drake
Gender: Male
Age: 26 Achenaran Standard Years, apparent age 25 human years due to chrysalis treatment
Race: Achenaran
Appearance: Unless one knew exactly what to look for, they would not be able to distinguish Achenaran from humans. Even if they did know what to look for, it would be difficult. James Drake has brown hair and eyes that shift in color from grey to blue to green.
Crew position: Owner, Commander and Corsair of the Vengeance
Skills: Tactics (space, ground, and shipboard combat), Battlesuit (medium and heavy), Beam weapons (graviton plasma), melee (Achenaran blademaster), unarmed combat (Achenaran Ku martial arts), piloting (spacefighter, medium starship), gunner (graviton plasma, fusion, antiparticle)
Merits: Achenaran citizenship, genetic enhancements, "guinea pig" for Anne's experiments with using chrysalis to enhance body structure.
Flaws: Impatience with red tape and politics, lack of subtlety. Though he is more tolerant of non-Achenarans than most of his kind, a bit of the Achenaran superiority complex carries over anyway.
History: James Drake grew up in the Janissary Program, a government-sponsored program that educates and raises orphans, offering them an officer commission once they turn 10 (10 Achenaran Standard years = approximately 18 Earth years). Drake accepted the commission at age 10, and quickly found himself assigned to Achenaran Special Forces due to his aptitude and willingness to undergo genetic augmentation. After serving 10 years in the Imperial Armada, Drake retired with full pension due to his exemplary service. Upon retirement he invested in an interstellar merchant vessel, venturing outside Achenaran space to trade. He invested in defensive armaments to ward of pirates and his guns got bigger and bigger, and gradually the Marlin evolved into a privateer vessel with full armament. He lost his Achenaran crew due to incidents he does not discuss, and is investing in a new crew composed of all races willing to join and remain loyal.
And the Executive officer, an AI organism that created a biological body to transfer her consciousness into
Some information on the Achenaran Corsair Destroyer owned by James Drake
Previous stories:
Current story:


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Civil War Interactive Discussion Board > Civil War Talk > Other Civil War Talk > Join the Civil War Top 100 Web Site |
Moderated by: javal1 |
Join the Civil War Top 100 Web Site | Rate Topic |
Author | Post |
Posted: Wed Jun 4th, 2008 11:43 pm |
1st Post |
bschulte Siege of Petersburg Fan
Guys, I am not affiliated with the Civil War Top 100 in any way except for the fact that my blog TOCWOC is listed there. With that said, I encourage you to check out Chris Wehner's Civil War Top 100 web site. Chris was kind enough to take over the maintenance of this page from me several years ago. What is a top site, I know some of you must be asking. The explanation is simple. A top site page counts the number of times your site receives a "hit" from someone who views the site. The site with the largest number of "hits" resides in the top spot on the Civil War Top 100 site. Sites move up and down throughout the day as more and more hits are tabulated. Okay, you're saying, that's great, but what's the point? There are several. Top sites allow users to quickly find a plethora of links on their topic of interest, in our case the Civil War. More importantly for members of the site, it allows their sites to receive exposure they otherwise wouldn't receive, thus increasing all-important traffic to your site. Top sites then work in much the same way other methods of exposure such as web rings and blog carnivals do. If you increase traffic, you increase the number of people reading your blog or looking at your web site on an everyday basis. Another nice feature is the stats area, available to all viewers. You can see what types of hits each site has been getting lately, leave comments, and even rank the sites on a scale of 1-5. Here are the stats from TOCWOC as an example. Interested yet? If, so I encourage you all to join the Civil War Top 100. Several of my fellow bloggers are there already, including the good group of Professors at Civil Warriors, Drew Wagenhoffer at Civil War Books and Authors, Harry Smeltzer at Bull Runnings, the trio at Touch the Elbow, Rene Tyree at wig-wags, and Maggiemac at Civil War Women, who currently puts the guys to shame with her daily hits! |
Posted: Thu Jun 5th, 2008 02:59 pm |
2nd Post |
javal1 Grumpy Geezer
Brett - I have added CWi. I would encourage other webmasters to support the Top 100 page as well. And of course, we ask all readers of CWi (and this board) to enter a vote for CWi by clicking on one of the Top 100 buttons. One is l9ocated in the right sidebar of the main page of the Discussion Board, and another is at the bottom of the CWi Home Page. |
Posted: Thu Jun 5th, 2008 03:23 pm |
3rd Post |
bschulte Siege of Petersburg Fan
Thanks! It's a community that benefits everyone if more sites are signed up. |
Posted: Thu Dec 29th, 2011 05:36 am |
4th Post |
marshal90 Member
War is not good for our lives.It claims life.Wars are not liked by many in the society and with the passage of time with the development of new and dangerous weapons, wars are the most haunted of all the horrors. Wars, when broke, not only take lives but also take decisive steps towards one group giving the losses and the humiliation to the other group. Same happened in civil war. Below are given some facts about it.It's better to now about Civil War Facts.Thank you very much for this valuable discussion. Last edited on Thu Dec 29th, 2011 05:38 am by marshal90 |
Current time is 06:33 pm | |
Civil War Interactive Discussion Board > Civil War Talk > Other Civil War Talk > Join the Civil War Top 100 Web Site | Top |