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CoreMedical Group – Fitchburg, MA
Demeritt Permanent Placement Specialist CoreMedical Group (phone) 800-995-2673 ext. 1339 (fax) 866-420... Specialist CoreMedical Group (phone… Indeed.com
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Updated Dec 5, 2013
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1 person found this helpful
I have been working at Barilla America
Pros – Company makes great product with focus on quality & leadership is passionate about business growth. Upbeat environment, flexible work schedule depending on the dept, effort to make company a fun place to work. Very good benefits package. Good work/life balance. Decent training programs.
Cons – Very limited chances to get experience in different depts or get promoted. Tend to hire new mgmt from the outside only. Dealings with corporate HQ in Italy difficult due to language barrier resulting in miscommunications. Mgmt unable to be flexible in decision making since decisions are controlled by Italy corporate HQ
Advice to Senior Management – ...
I worked at Barilla America full-time for more than 3 years
2 people found this helpful
I have been working at Barilla America
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subset: commoncrawl


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When it shatters its plaster cocoon, it will emerge as a beautiful marbled cat/fly! - Matty Malaprop
This 5-Year-Old Made the Cutest AND Most Heroic 911 Call at the Same Time
Poor Guy Tries to Sell His Unwanted Engagement Ring
Paris Hilton's Fake Tweet About Nelson Mandela's Death
How to Make a Pokebra and 12 of the Very Best Creations
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Investigators looking into the murder of a Boston man are looking at whether Aaron Hernandez asked his girlfriend to dispose of a box containing the murder weapon shortly after the shooting.
According to an Associated Press story, search warrants were issued for a Bristol, Conn., storage facility after surveillance video footage from the former New England Patriot's home is believed to show Hernandez' girlfriend, Shayanna Jenkins, carrying a rigid object the size of a lock box out of the house the two shared and loading it into her sister's car.
Other court documents show that Carlos Ortiz, a man also charged in the shooting of Odin Lloyd, told police Hernandez put two guns in a box and stored it in his basement following the shooting.
The Bristol Press reported Friday that warrants claim Jenkins may have dumped that box in the woods or put it in a Bristol storage unit that Hernandez paid for.Hernandez is charged in the murder of Lloyd, a semi-professional football player from Boston. Lloyd was shot to death in June and his body was found about a mile from Hernandez's home.
For the full story, see The Associated Press.


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Summer sports are in full swing.
As we get our children's protective gear — like helmets and knee pads — packed into duffle bags, there's one more thing you might want to consider getting your child: a vaccination for meningitis.
Twelve-time Olympic medalist Dara Torres hopes to amp-up vaccination awareness, especially among parents of active children.
"Parents like me do all they can to protect their kids from harm, making sure they have the right equipment and protective gear when they're playing sports," she said. "But there is one thing parents might be forgetting to guard their kids against – meningococcal disease."
Torres — who has a daughter, 7, and 13-year-old twins — joined the Get in the Game prevention campaign after finding out that meningitis can kill a healthy child in as little as 24 hours.
The stats were shocking, she said.
For example 10 to 15 percent of the 800 to 1,200 Americans who get meningococcal disease each year will pass away from the disease.
Of those who survive, nearly one in five are left with serious medical problems, including: amputation of arms, legs, fingers and toes; neurologic damage; deafness and kidney damage.
Momaha recently spoke with Torres and Beth Mattey of the National Association of School Nurses about the meningococcal disease and prevention campaign.
Here's what they had to say:


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Hooked - (Stacia Naquin)
Updated: 10/11/2013 - I'm SO CLOSE to being able to do a pull-up. So my trainer introduced something new into my training.
Credit: AP
Dozens have gathered to remember the siege on the Branch Davidians' Texas compound on the 20th anniversary of the 51-day standoff's fiery end.
Survivors and others who see the events as an unwarranted government intrusion into personal and religious freedoms are attending a Friday memorial service at a Waco museum. One survivor read the names of the nearly 80 sect members who died on April 19, 1993.
Federal agents raided the compound Feb. 28, 1993, trying to arrest sect leader David Koresh for stockpiling illegal weapons. But the group had been tipped off about the raid and a shootout ensued. Four agents and six Davidians were killed.
Several women and children left the compound during the standoff, which ended after tear gas was fired inside and it burned.
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powered by DisqusUpdated: 10/11/2013 - I'm SO CLOSE to being able to do a pull-up. So my trainer introduced something new into my training.
Posted: 08/06/2013 - Even if you don't plan to workout on your vacation, you may be surprised at the calories you're burning without even trying!
Updated: 06/18/2013 - We did a quick helicopter tour of the Black Forest burn area. Someone asked why the video looks shaky.
Updated: 05/20/2013 - Two weekends left to catch one great show!
Updated: 05/14/2013 - I'm still focused on meeting my goal of doing a pull-up. And I'm almost there! But I'm always getting this question:


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I stayed here for two nights. As a lone traveller a busy city can be a bit overwhelming. However the owners made me feel so welcome & were so very helpful that I immediately felt fine. The rooms are clean, modern and the lift is a massive bonus. I have to say again what lovely people the owners are!
- Reservation Options:
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It's on-disc.
04 July 2013 - 01:44 PM
It's on-disc.
04 July 2013 - 01:39 PM
Maybe not in particular what you are looking for but here is one:
Nintendo Wii U Console - 32GB Black Deluxe Set (G) $277.97
Fallout: New Vegas Ultimate Edition (G) $12.86
PS3 Racing Wheel Controller (LN) $37.85
I saw Animal Crossing: New Leaf (VG for $21.82) but that went fast along with Far Cry 3 (LN for $14.84) and Just Dance 4 (LN for $14.84)
Does anyone know if the dlc included in Fallout: New Vegas Ultimate Edition is on disc or if it comes with codes?
03 July 2013 - 10:35 AM
Panasonic has a 3DS over at the Trade thread [link to trade list]
03 July 2013 - 10:24 AM
I'm looking for a 3ds b/c I want to play animal crossing too.
Not a great deal, but Fry's has a 2-Day sale going on that includes 3DS (black, pink, and purple) for $149.99 [link]
02 July 2013 - 10:09 PM
We're in the same boat. I'm looking for one too.
They have some listed at cowboom.com, but they've rated 4 (significant scratches or scuffs) with most accessories missing. Meh.
Also, there is a sale going on at SharkStores.com (use code GETINTHEGAME to get the regular 3DS to drop to $125 w/free shipping) but they're open box and I hear shipping takes around 2 weeks (even if you pay for expedited shipping), But in two weeks, a better deal will probably come along.
I'm waiting on a 4th of July sale too, but I'm not seeing anything. Maybe Bestbuy will have a deal on that day?
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Curators at India's Baroda Museum reported
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person who apparently opened the mummy's case and vacuumed the body. The vacuum removed
ancient dust, peeled toe paint, sucked off part of the nose, and loosened bandages.
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First! was killed near Fortuna, CA, when one of the trees fell on him.
In an unconfirmed report, a spokesperson for the
Italian Gattinoni fashion house announced Monica Lewinsky has agreed to model a blue
two-piece suit there during an October Roma Outsize fashion show in Milan. She'll
supposedly get $470,000, half of which will go to charity.... Gattinoni recently unveiled a flesh-colored skin-tight condom dress decorated with
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Saturday in Beaumont TX a 20-minute halftime
brawl erupted between the Southern University and Prairie View A&M marching bands as
the formations passed each other. Three people were taken to the hospital, four $5,000
tubas were bent, and one saxophone plus several pieces of uniform were reported missing.
Avon is finally eschewing its all-door-to-door selling strategy and starting retail discount outlets.
October's National Geographic will be the magazine's first with a scent strip. It's a scientific recreation of Cleopatra's perfume.
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- November 11, 2010
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Punched_By_Lady_Luck writes:
in response to MzLillian:
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How does a large, vocal MAJORITY play the "poor us, we're being repressed!" card?
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APNewsBreak: NY Gov. Andrew Cuomo has book deal
NEW YORK (AP) — Andrew Cuomo, the popular governor and a possible presidential contender in 2016, has a book deal.
HarperCollins told The Associated Press on Monday that Cuomo will write "a full and frank account" about his private life and the "profound moments" of his first term in office, including signing gay-marriage legislation. Financial terms of the deal weren't disclosed.
Cuomo, a Democrat who hasn't declared his plans for 2016, was represented by a man with much experience in handling presidents and presidential contenders, Washington attorney Robert Barnett, whose clients include President Barack Obama and another possible 2016 candidate, former Secretary of State Hillary Rodham Clinton.
The Cuomo book is scheduled for next year, when Clinton also has a book expected.
Earlier Monday, Cuomo dismissed reports that he would not seek the presidency should Clinton run, saying that he was focused on being governor.
Cuomo's deal may complicate plans for a biography on the governor signed up by HarperCollins last year. HarperCollins spokeswoman Tina Andreadis said Monday that the book, by New York Post reporter and state editor Fredric Dicker, was still under contract. The Post and HarperCollins are part of Rupert Murdoch's News Corp.
Cuomo, 55, was secretary of Housing and Urban Development during President Bill Clinton's administration and served four years as New York's attorney general before being elected governor in 2010. He has signed legislation allowing gay couples to marry in the state, helped secure financial aid for victims of Superstorm Sandy and signed tough gun control legislation into law after the deadly Newtown, Conn., elementary school shooting.
In the book, Cuomo will write about being the father to three girls, his role in establishing housing for the homeless and the legacy of his father, former Gov. Mario Cuomo.
Monday's announcement did not mention Cuomo's marriage to Kerry Kennedy, daughter of the late Sen. Robert F. Kennedy, and their bitter divorce in 2005. The publisher declined to comment on whether Cuomo would write about Kennedy, the mother of his children.
Cuomo now lives with Food Network star Sandra Lee.
AP National Writer Hillel Italie contributed to this report.
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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Publications (49)311.06 Total impact
- [show abstract] [hide abstract]
ABSTRACT: The advent of publicly available databases containing system-wide phenotypic data of the host response to both drugs and pathogens, in conjunction with bioinformatics and computational methods now allows for in silico predictions of FDA-approved drugs as treatments against infection diseases. This systems biology approach captures the complexity of both the pathogen and drug host response in the form of expression patterns or molecular interaction networks without having to understand the underlying mechanisms of action. These drug repurposing techniques have been successful in identifying new drug candidates for several types of cancers and were recently used to identify potential therapeutics against influenza, the newly discovered Middle Eastern Respiratory Syndrome coronavirus and several parasitic diseases. These new approaches have the potential to significantly reduce both the time and cost for infectious diseases drug discovery.Current opinion in immunology 09/2013; · 10.88 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: High-throughput molecular profiling and computational biology are changing the face of virology, providing a new appreciation of the importance of the host in viral pathogenesis and offering unprecedented opportunities for better diagnostics, therapeutics and vaccines. Here, we provide a snapshot of the evolution of systems virology, from global gene expression profiling and signatures of disease outcome, to geometry-based computational methods that promise to yield novel therapeutic targets, personalized medicine and a deeper understanding of how viruses cause disease. To realize these goals, pipettes and Petri dishes need to join forces with the powers of mathematics and computational biology.Nature Reviews Microbiology 06/2013; · 22.49 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Nonhuman primate (NHP) biomedical models are critical to our understanding of human health and disease, yet we are still in the early stages of developing sufficient tools to support primate genomic research that allow us to better understand the basis of phenotypic traits in NHP models of disease. A mere 7 years ago, the limited NHP transcriptome profiling that was being performed was done using complementary DNA arrays based on human genome sequences, and the lack of NHP genomic information and immunologic reagents precluded the use of NHPs in functional genomic studies. Since then, significant strides have been made in developing genomics capabilities for NHP research, from the rhesus macaque genome sequencing project to the construction of the first macaque-specific high-density oligonucleotide microarray, paving the way for further resource development and additional primate sequencing projects. Complete published draft genome sequences are now available for the chimpanzee ( Chimpanzee Sequencing Analysis Consortium 2005), bonobo ( Prufer et al. 2012), gorilla ( Scally et al. 2012), and baboon ( Ensembl.org 2013), along with the recently completed draft genomes for the cynomolgus macaque and Chinese rhesus macaque. Against this backdrop of both expanding sequence data and the early application of sequence-derived DNA microarrays tools, we will contextualize the development of these community resources and their application to infectious disease research through a literature review of NHP models of acquired immune deficiency syndrome and models of respiratory virus infection. In particular, we will review the use of -omics approaches in studies of simian immunodeficiency virus and respiratory virus pathogenesis and vaccine development, emphasizing the acute and innate responses and the relationship of these to the course of disease and to the evolution of adaptive immunity.ILAR journal / National Research Council, Institute of Laboratory Animal Resources 01/2013; 54(2):166-80. · 1.58 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Influenza virus research has recently undergone a shift from a virus-centric perspective to one that embraces the full spectrum of virus-host interactions and cellular signaling events that determine disease outcome. This change has been brought about by the increasing use and expanding scope of high-throughput molecular profiling and computational biology, which together fuel discovery in systems biology. In this review, we show how these approaches have revealed an uncontrolled inflammatory response as a contributor to the extreme virulence of the 1918 pandemic and avian H5N1 viruses, and how this response differs from that induced by the 2009 H1N1 viruses responsible for the most recent influenza pandemic. We also discuss how new animal models, such as the Collaborative Cross mouse systems genetics platform, are key to the necessary systematic investigation of the impact of host genetics on infection outcome, how genome-wide RNAi screens have identified hundreds of cellular factors involved in viral replication, and how systems biology approaches are making possible the rational design of new drugs and vaccines against an ever-evolving respiratory virus.Seminars in Immunology 12/2012; · 5.93 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Hepatitis C virus/human immunodeficiency virus (HCV/HIV) coinfected patients demonstrate accelerated progression to severe liver injury in comparison to HCV monoinfected patients, although the underlying mechanisms are unclear owing to infection of separate tissue compartments with two distinct viral pathogens. Microarray analysis of paired liver biopsy and peripheral blood mononuclear cell (PBMC) specimens from HCV/HIV coinfected and HCV monoinfected patients identified a gene expression signature associated with increased inflammation and immune activation that was present only in liver and PBMC samples from coinfected patients. We also identified in these samples liver- and PBMC-specific signatures enriched with fibrogenic/hepatic stellate activation and proinflammatory genes, respectively. Finally, Bayesian networks were constructed by assimilating these data with existing data from liver and PBMC samples from other cohorts, augmenting enrichment of biologically important pathways and further indicating that chronic immune activation in HCV/HIV coinfection may exacerbate liver disease progression in coinfected patients.Virology 05/2012; 430(1):43-52. · 3.35 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Human immunodeficiency virus (HIV-1) depends upon host-encoded proteins to facilitate its replication while at the same time inhibiting critical components of innate and/or intrinsic immune response pathways. To characterize the host cell response on protein levels in CD4+ lymphoblastoid SUP-T1 cells after infection with HIV-1 strain LAI, we used mass spectrometry (MS)-based global quantitation with iTRAQ (isobaric tag for relative and absolute quantification). We found 266, 60 and 22 proteins differentially expressed (DE) (P-value ≤ 0.05) at 4, 8, and 20 hours post-infection (hpi), respectively, compared to time-matched mock-infected samples. The majority of changes in protein abundance occurred at an early stage of infection well before the de novo production of viral proteins. Functional analyses of these DE proteins showed enrichment in several biological pathways including protein synthesis, cell proliferation, and T-cell activation. Importantly, these early changes before the time of robust viral production have not been described before.Virology 04/2012; 429(1):37-46. · 3.35 Impact Factor -
Article: Into the eye of the cytokine storm.
[show abstract] [hide abstract]
ABSTRACT: The cytokine storm has captured the attention of the public and the scientific community alike, and while the general notion of an excessive or uncontrolled release of proinflammatory cytokines is well known, the concept of a cytokine storm and the biological consequences of cytokine overproduction are not clearly defined. Cytokine storms are associated with a wide variety of infectious and noninfectious diseases. The term was popularized largely in the context of avian H5N1 influenza virus infection, bringing the term into popular media. In this review, we focus on the cytokine storm in the context of virus infection, and we highlight how high-throughput genomic methods are revealing the importance of the kinetics of cytokine gene expression and the remarkable degree of redundancy and overlap in cytokine signaling. We also address evidence for and against the role of the cytokine storm in the pathology of clinical and infectious disease and discuss why it has been so difficult to use knowledge of the cytokine storm and immunomodulatory therapies to improve the clinical outcomes for patients with severe acute infections.Microbiology and molecular biology reviews: MMBR 03/2012; 76(1):16-32. · 12.59 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Liver failure resulting from chronic hepatitis C virus (HCV) infection is a major cause for liver transplantation worldwide. Recurrent infection of the graft is universal in HCV patients after transplant and results in a rapid progression to severe fibrosis and end-stage liver disease in one third of all patients. No single clinical variable, or combination thereof, has, so far, proven accurate in identifying patients at risk of hepatic decompensation in the transplant setting. A combination of longitudinal, dimensionality reduction and categorical analysis of the transcriptome from 111 liver biopsy specimens taken from 57 HCV-infected patients over time identified a molecular signature of gene expression of patients at risk of developing severe fibrosis. Significantly, alterations in gene expression occur before histologic evidence of liver disease progression, suggesting that events that occur during the acute phase of infection influence patient outcome. Additionally, a common precursor state for different severe clinical outcomes was identified. CONCLUSION: Based on this patient cohort, incidence of severe liver disease is a process initiated early during HCV infection of the donor organ. The probable cellular network at the basis of the initial transition to severe liver disease was identified and characterized.Hepatology 01/2012; 56(1):17-27. · 12.00 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Understanding the role of host factors during lethal influenza virus infection is critical to deciphering the events that determine the fate of the host. One such factor is encoded by the Mx1 gene, which confers resistance to influenza virus infection. Here, we compared pathology and global gene expression profiles in lung tissue from BALB/c (Mx1(-)) and BALB · A2G-Mx1 mice (Mx1(+/+)) infected with the fully reconstructed 1918 pandemic influenza virus. Mx1(+/+) mice showed less tissue damage than Mx(-) animals, and pathology and mortality were further reduced by treating the mice with interferon prior to infection. Using global transcriptional profiling, we identified distinct molecular signatures associated with partial protection, complete protection, and the contribution of interferon to the host response. In the absence of interferon treatment, partial protection was characterized by the generation of an acute response with the upregulation of genes associated with apoptosis, reactive oxygen species, and cell migration. Complete protection was characterized by the downregulation of cytokine and chemokine genes previously associated with influenza virus pathogenesis. The contribution of interferon treatment to total protection in virus-infected Mx1(+/+) mice was characterized by the altered regulation of cell cycle genes. These genes were upregulated in Mx1(+/+) mice treated with interferon but downregulated in the absence of interferon treatment. Our results suggest that Mx1(+/+) mice generate a protective antiviral response by controlling the expression of key modulator molecules associated with influenza virus lethality.Journal of Virology 12/2011; 86(5):2437-46. · 5.08 Impact Factor - Journal of General Virology 10/2011; 92(Pt 10):2466. · 3.13 Impact Factor
- [show abstract] [hide abstract]
ABSTRACT: We previously employed systems biology approaches to identify the mitochondrial fatty acid oxidation enzyme dodecenoyl coenzyme A delta isomerase (DCI) as a bottleneck protein controlling host metabolic reprogramming during hepatitis C virus (HCV) infection. Here we present the results of studies confirming the importance of DCI to HCV pathogenesis. Computational models incorporating proteomic data from HCV patient liver biopsy specimens recapitulated our original predictions regarding DCI and link HCV-associated alterations in cellular metabolism and liver disease progression. HCV growth and RNA replication in hepatoma cell lines stably expressing DCI-targeting short hairpin RNA (shRNA) were abrogated, indicating that DCI is required for productive infection. Pharmacologic inhibition of fatty acid oxidation also blocked HCV replication. Production of infectious HCV was restored by overexpression of an shRNA-resistant DCI allele. These findings demonstrate the utility of systems biology approaches to gain novel insight into the biology of HCV infection and identify novel, translationally relevant therapeutic targets.Journal of Virology 09/2011; 85(22):11646-54. · 5.08 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Ebola virus is the etiologic agent of a lethal hemorrhagic fever in humans and nonhuman primates with mortality rates of up to 90%. Previous studies with Zaire Ebola virus (ZEBOV), mouse-adapted virus (MA-ZEBOV), and mutant viruses (ZEBOV-NP(ma), ZEBOV-VP24(ma), and ZEBOV-NP/VP24(ma)) allowed us to identify the mutations in viral protein 24 (VP24) and nucleoprotein (NP) responsible for acquisition of high virulence in mice. To elucidate specific molecular signatures associated with lethality, we compared global gene expression profiles in spleen samples from mice infected with these viruses and performed an extensive functional analysis. Our analysis showed that the lethal viruses (MA-ZEBOV and ZEBOV-NP/VP24(ma)) elicited a strong expression of genes 72 h after infection. In addition, we found that although the host transcriptional response to ZEBOV-VP24(ma) was nearly the same as that to ZEBOV-NP/VP24(ma), the contribution of a mutation in the NP gene was required for a lethal phenotype. Further analysis indicated that one of the most relevant biological functions differentially regulated by the lethal viruses was the inflammatory response, as was the induction of specific metalloproteinases, which were present in our newly identify functional network that was associated with Ebola virus lethality. Our results suggest that this dysregulated proinflammatory response increased the severity of disease. Consequently, the newly discovered molecular signature could be used as the starting point for the development of new drugs and therapeutics. To our knowledge, this is the first study that clearly defines unique molecular signatures associated with Ebola virus lethality.Journal of Virology 09/2011; 85(17):9060-8. · 5.08 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: The NS1 protein of influenza virus counters host antiviral defences primarily by antagonizing the type I interferon (IFN) response. Both the N-terminal dsRNA-binding domain and the C-terminal effector domain are required for optimal suppression of host responses during infection. To better understand the regulatory role of the NS1 effector domain, we used an NS1-truncated mutant virus derived from human H1N1 influenza isolate A/Texas/36/91 (Tx/91) and assessed global transcriptional profiles from two independent human lung cell-culture models. Relative to the wild-type Tx/91-induced gene expression, the NS1 mutant virus induced enhanced expression of innate immune genes, specifically NF-κB signalling-pathway genes and IFN-α and -β target genes. We queried an experimentally derived IFN gene set to gauge the proportion of IFN-responsive genes that are suppressed specifically by NS1. We show that the C-terminally truncated NS1 mutant virus is less efficient at suppressing IFN-regulated gene expression associated with activation of antigen-presentation and immune-proteasome pathways. This is the first report integrating genomic analysis from two independent human culture systems, including primary lung cells, using genetically similar H1N1 influenza viruses that differ only in the length of the NS1 protein.Journal of General Virology 05/2011; 92(Pt 9):2093-104. · 3.13 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: We previously reported widespread differential expression of long non-protein-coding RNAs (ncRNAs) in response to virus infection. Here, we expanded the study through small RNA transcriptome sequencing analysis of the host response to both severe acute respiratory syndrome coronavirus (SARS-CoV) and influenza virus infections across four founder mouse strains of the Collaborative Cross, a recombinant inbred mouse resource for mapping complex traits. We observed differential expression of over 200 small RNAs of diverse classes during infection. A majority of identified microRNAs (miRNAs) showed divergent changes in expression across mouse strains with respect to SARS-CoV and influenza virus infections and responded differently to a highly pathogenic reconstructed 1918 virus compared to a minimally pathogenic seasonal influenza virus isolate. Novel insights into miRNA expression changes, including the association with pathogenic outcomes and large differences between in vivo and in vitro experimental systems, were further elucidated by a survey of selected miRNAs across diverse virus infections. The small RNAs identified also included many non-miRNA small RNAs, such as small nucleolar RNAs (snoRNAs), in addition to nonannotated small RNAs. An integrative sequencing analysis of both small RNAs and long transcripts from the same samples showed that the results revealing differential expression of miRNAs during infection were largely due to transcriptional regulation and that the predicted miRNA-mRNA network could modulate global host responses to virus infection in a combinatorial fashion. These findings represent the first integrated sequencing analysis of the response of host small RNAs to virus infection and show that small RNAs are an integrated component of complex networks involved in regulating the host response to infection. IMPORTANCE: Most studies examining the host transcriptional response to infection focus only on protein-coding genes. However, mammalian genomes transcribe many short and long non-protein-coding RNAs (ncRNAs). With the advent of deep-sequencing technologies, systematic transcriptome analysis of the host response, including analysis of ncRNAs of different sizes, is now possible. Using this approach, we recently discovered widespread differential expression of host long (>200 nucleotide [nt]) ncRNAs in response to virus infection. Here, the samples described in the previous report were again used, but we sequenced another fraction of the transcriptome to study very short (about 20 to 30 nt) ncRNAs. We demonstrated that virus infection also altered expression of many short ncRNAs of diverse classes. Putting the results of the two studies together, we show that small RNAs may also play an important role in regulating the host response to virus infection.mBio 01/2011; 2(6). · 5.62 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: The twentieth century was marked by extraordinary advances in our understanding of microbes and infectious disease, but pandemics remain, food and waterborne illnesses are frequent, multidrug-resistant microbes are on the rise, and the needed drugs and vaccines have not been developed. The scientific approaches of the past-including the intense focus on individual genes and proteins typical of molecular biology-have not been sufficient to address these challenges. The first decade of the twenty-first century has seen remarkable innovations in technology and computational methods. These new tools provide nearly comprehensive views of complex biological systems and can provide a correspondingly deeper understanding of pathogen-host interactions. To take full advantage of these innovations, the National Institute of Allergy and Infectious Diseases recently initiated the Systems Biology Program for Infectious Disease Research. As participants of the Systems Biology Program, we think that the time is at hand to redefine the pathogen-host research paradigm.mBio 01/2011; 2(1):e00325-10. · 5.62 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Severe acute respiratory syndrome coronavirus (SARS-CoV) infection can cause the development of severe end-stage lung disease characterized by acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. The mechanisms by which pulmonary lesions and fibrosis are generated during SARS-CoV infection are not known. Using high-throughput mRNA profiling, we examined the transcriptional response of wild-type (WT), type I interferon receptor knockout (IFNAR1-/-), and STAT1 knockout (STAT1-/-) mice infected with a recombinant mouse-adapted SARS-CoV (rMA15) to better understand the contribution of specific gene expression changes to disease progression. Despite a deletion of the type I interferon receptor, strong expression of interferon-stimulated genes was observed in the lungs of IFNAR1-/- mice, contributing to clearance of the virus. In contrast, STAT1-/- mice exhibited a defect in the expression of interferon-stimulated genes and were unable to clear the infection, resulting in a lethal outcome. STAT1-/- mice exhibited dysregulation of T-cell and macrophage differentiation, leading to a TH2-biased immune response and the development of alternatively activated macrophages that mediate a profibrotic environment within the lung. We propose that a combination of impaired viral clearance and T-cell/macrophage dysregulation causes the formation of prefibrotic lesions in the lungs of rMA15-infected STAT1-/- mice.Journal of Virology 11/2010; 84(21):11297-309. · 5.08 Impact Factor -
Article: Pandemic swine-origin H1N1 influenza A virus isolates show heterogeneous virulence in macaques.
[show abstract] [hide abstract]
ABSTRACT: The first influenza pandemic of the new millennium was caused by a newly emerged swine-origin influenza virus (SOIV) (H1N1). This new virus is characterized by a previously unknown constellation of gene segments derived from North American and Eurasian swine lineages and the absence of common markers predictive of human adaptation. Overall, human infections appeared to be mild, but an alarming number of young individuals presented with symptoms atypical for seasonal influenza. The new SOIV also showed a sustained human-to-human transmissibility and higher reproduction ratio than common seasonal viruses, altogether indicating a higher pathogenic potential for this newly emerged virus. To study the virulence of the SOIV, we used a recently established cynomolgus macaque model and compared parameters of clinical disease, virology, host responses, and pathology/histopathology with a current seasonal H1N1 virus. We here show that infection of macaques with two genetically similar but clinically distinct SOIV isolates from the early stage of the pandemic (A/Mexico/4108/2009 and A/Mexico/InDRE4487/2009) resulted in upper and lower respiratory tract infections and clinical disease ranging from mild to severe pneumonia that was clearly advanced over the mild infection caused by A/Kawasaki/UTK-4/2009, a current seasonal strain. Unexpectedly, we observed heterogeneity among the two SOIV isolates in virus replication, host transcriptional and cytokine responses, and disease progression, demonstrating a higher pathogenic potential for A/Mexico/InDRE4487/2009. Differences in virulence may explain more severe disease, as was seen with certain individuals infected with the emerged pandemic influenza virus. Thus, the nonhuman primate model closely mimics influenza in humans.Journal of Virology 11/2010; 85(3):1214-23. · 5.08 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: We have employed global transcriptional profiling of whole blood to identify biologically relevant changes in cellular gene expression in response to alternative AIDS vaccine strategies with subsequent viral challenge in a rhesus macaque vaccine model. Samples were taken at day 0 (prechallenge), day 14 (peak viremia), and week 12 (set point) from animals immunized with replicating adenovirus type 5 host range (Ad5hr) recombinant viruses expressing human immunodeficiency virus HIV(env)(89.6P), simian immunodeficiency virus SIV(gag)(239), or SIV(nef)(239) alone or in combination with two intramuscular boosts with HIV(89.6P)gp140ΔCFI protein (L. J. Patterson et al., Virology 374:322-337, 2008), and each treatment resulted in significant control of viremia following simian-human immunodeficiency virus SHIV(89.6P) challenge (six animals per group plus six controls). At day 0, 8 weeks after the last treatment, the microarray profiles revealed significant prechallenge differences between treatment groups; data from the best-protected animals led to identification of a network of genes related to B cell development and lymphocyte survival. At peak viremia, expression profiles of the immunized groups were extremely similar, and comparisons to control animals reflected immunological differences other than effector T cell functions. Suggested protective mechanisms for vaccinated animals included upregulation of interleukin-27, a cytokine known to inhibit lentivirus replication, and increased expression of complement components, which may synergize with vaccine-induced antibodies. Divergent expression profiles at set point for the immunized groups implied distinct immunological responses despite phenotypic similarities in viral load and CD4(+) T cell levels. Data for the gp140-boosted group provided evidence for antibody-dependent, cell-mediated viral control, whereas animals immunized with only the replicating Ad5hr recombinants exhibited a different evolution of the B cell compartment even at 3 months postchallenge. This study demonstrates the sensitivity and discrimination of gene expression profiling of whole blood as an analytical tool in AIDS vaccine trials, providing unique insights into in vivo mechanisms and potential correlates of protection.Journal of Virology 11/2010; 85(2):1099-116. · 5.08 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: The influenza pandemic of 1918 to 1919 was one of the worst global pandemics in recent history. The highly pathogenic nature of the 1918 virus is thought to be mediated in part by a dysregulation of the host response, including an exacerbated proinflammatory cytokine response. In the present study, we compared the host transcriptional response to infection with the reconstructed 1918 virus in wild-type, tumor necrosis factor (TNF) receptor-1 knockout (TNFRKO), and interleukin-1 (IL-1) receptor-1 knockout (IL1RKO) mice as a means of further understanding the role of proinflammatory cytokine signaling during the acute response to infection. Despite reported redundancy in the functions of IL-1β and TNF-α, we observed that reducing the signaling capacity of each of these molecules by genetic disruption of their key receptor genes had very different effects on the host response to infection. In TNFRKO mice, we found delayed or decreased expression of genes associated with antiviral and innate immune signaling, complement, coagulation, and negative acute-phase response. In contrast, in IL1RKO mice numerous genes were differentially expressed at 1 day postinoculation, including an increase in the expression of genes that contribute to dendritic and natural killer cell processes and cellular movement, and gene expression profiles remained relatively constant at later time points. We also observed a compensatory increase in TNF-α expression in virus-infected IL1RKO mice. Our data suggest that signaling through the IL-1 receptor is protective, whereas signaling through the TNF-α receptor increases the severity of 1918 virus infection. These findings suggest that manipulation of these pathways may have therapeutic benefit.Journal of Virology 10/2010; 84(24):12576-88. · 5.08 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Periodic outbreaks of highly pathogenic avian H5N1 influenza viruses and the current H1N1 pandemic highlight the need for a more detailed understanding of influenza virus pathogenesis. To investigate the host transcriptional response induced by pathogenic influenza viruses, we used a functional-genomics approach to compare gene expression profiles in lungs from 129S6/SvEv mice infected with either the fully reconstructed H1N1 1918 pandemic virus (1918) or the highly pathogenic avian H5N1 virus Vietnam/1203/04 (VN/1203). Although the viruses reached similar titers in the lung and caused lethal infections, the mean time of death was 6 days for VN/1203-infected animals and 9 days for mice infected with the 1918 virus. VN/1203-infected animals also exhibited an earlier and more potent inflammatory response. This response included induction of genes encoding components of the inflammasome. VN/1203 was also able to disseminate to multiple organs, including the brain, which correlated with changes in the expression of genes associated with hematological functions and lipoxin biogenesis and signaling. Both viruses elicited expression of type I interferon (IFN)-regulated genes in wild-type mice and to a lesser extent in mice lacking the type I IFN receptor, suggesting alternative or redundant pathways for IFN signaling. Our findings suggest that VN/1203 is more pathogenic in mice as a consequence of several factors, including the early and sustained induction of the inflammatory response, the additive or synergistic effects of upregulated components of the immune response, and inhibition of lipoxin-mediated anti-inflammatory responses, which correlated with the ability of VN/1203 to disseminate to extrapulmonary organs.Journal of Virology 08/2010; 84(15):7613-24. · 5.08 Impact Factor
Top Journals
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Wisconsin National Primate Research Center
Madison, Wisconsin, United States
University of Washington Seattle
- Department of Microbiology
Seattle, WA, United States
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- Symposium Papers AvailableClick here to view available presentations http://theiwrc.org/symposium/
- Legal Framework for Wildlife RehabilitationAn IWRC Position Statement http://theiwrc.org/archives/3435
- What is WildHelp?An interview with the creator http://theiwrc.org/archives/3390
- Using the Wildlife Heath Event ReporterA Surveillance and Communication Tool http://theiwrc.org/archives/2862
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Disease Updates
The AAZA has released the 2nd edition of Infectious Diseases of Concern to Captive and Free ranging Wildlife in North America.
Minimum Standards for Wildlife Rehabilitation 4th Edition Released!
The US National Wildlife Rehabilitators Association (NWRA) and the International Wildlife Rehabilitators Council (IWRC) are pleased to announce the joint release of Minimum Standards for Wildlife Rehabilitation, 4th edition. This publication was reviewed and updated by experienced wildlife rehabilitators from around the country and provides useful information on appropriate cage sizes, disinfectants, and cage furniture while caring for wildlife undergoing rehabilitation. This 116-page book is available through NWRA or IWRC for $15.00.
Note: IWRC members may also download an electronic version of the 4th edition in the resources section under Science and Rehabilitation Resources. The 3rd edition is no longer available as a download.
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text: Patent ReferencesKeyboard and control system Patent #: 4333089 InventorsAssigneeApplicationNo. 06/345640 filed on 02/04/1982US Classes:703/25, I/O adapter (e.g., port, controller)711/104Solid-state random access memory (RAM)ExaminersPrimary: Zache, Raulfe B.Attorney, Agent or FirmInternational ClassesG06F 12/06 (20060101)G06F 12/02 (20060101) G11C 8/12 (20060101) G06F 3/06 (20060101) G11C 8/00 (20060101) Foreign Application Priority Data1981-02-09 JPAbstractA semiconductor random access memory system for use in a processor system is adapted to operate with a magnetic disc storage device, such as the so-called floppy-disc store. A semiconductor RAM has data input/output terminals and address terminals for writing data into or reading data out of a storage location that is addressed by an address signal supplied to the address terminals. Track and sector address registers are coupled to the processor system for receiving and storing the typical track and sector address signals normally generated in the system. A counter counts timing pulses to produce a changing count signal, which timing pulses are generated by a timing control circuit. An address synthesizer is coupled to the track and sector address registers and also to the counter for synthesizing a RAM address signal from the stored track and sector address signals as well as the count signal and for supplying this RAM address signal to the RAM address terminals to access the RAM storage location which is addressed thereby. Thus, when the processor system generates the typical track and sector address signals normally used with a floppy disc store, such track and sector address signals are used to address a typical semiconductor RAM. | |


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Administrative Assistant Jobs in West Mifflin, Pennsylvania
114 West Mifflin, PA Administrative Assistant jobs found on Monster.
Ajilon Professional Staffing is recruiting for an Administrative Assistant Job in Pittsburgh, PA. The ideal candidate will possess excellent computer and communication skills, be open to temporary positions, and have two years of recent experience in an office support role. Administrative Assistant Job Responsibilities include: · Performs secretarial duties · Prepares correspondence, memoranda, re...
EXECUTIVE ADMINISTRATIVE ASSISTANT TO THE CHAIRMAN PITTSBURGH OFFICE Orbital Engineering has provided worldwide professional engineering and consulting services since 1969. Our commitment to quality, responsiveness, and attention to detail has earned us the reputation as a leading provider of engineering and design services. Orbital has been consistently ranked among the Engineering News Record (E...
The Rohrich Automotive Group serving Pittsburgh and our neighbors is seeking a motivated Administrative Support – Clerical Assistant for an immediate opportunity amongst our family of eight (8) premier local dealerships. Job Requirements: Minimum of 2+ years of Administrative/Clerical experience Minimum Typing 50 wpm Proficient Microsoft office products 2+ years of Customer Service Accurate Data e...
The ideal candidate will have a minimum of 2-5 years experience as an administrative assistant. The following skills and attributes are also required: Strong communication skills and a highly positive attitude Experience in the Construction Industry is preferred but not required Knowledge of Quickbooks and Microsoft Office Ability to operate standard office equipment Experience with all aspects of...
ADMINISTRATIVE ASSISTANT Downtown non-profit healthcare agency is seeking individual to provide administrative support to a busy Communications and Development Department. Responsibilities include ordering, distribution and inventory management of printed materials; data entry for functions including donor records and mailing lists. Also provides general administrative/clerical support. Position r...
Administrative Assistant This is a full time entry level position at a fast paced professional office. Person would be responsible for a variety of administrative and clerical duties. Organize and maintain paper and electronic files; answering multi line phone system; processing of incoming mail; data entry, posting and sorting high volume mailings, delivering mail. Strong computer skills, working...
A Kforce client is seeking an Administrative Assistant in Pittsburgh, Pennsylvania (PA). Summary: Provide high-level administrative support by conducting research, handling information requests and performing clerical functions. Major Job Duties and Responsibilities: Perform general office duties such as ordering supplies, maintaining records management systems, and performing basic bookkeeping wo...
Ajilon Professional Staffing is hiring for an Administrative Assistant job in Pittsburgh, PA. Ajilon Professional Staffing is looking for motivated individuals who have experience in an administrative assistant role. If you have excellent people skills and great computer skills, then this is your chance to start a career at an established company in Verona, PA. This is a temporary to hire opportun...
A Kforce Client is seeking an Administrative Assistant in the Pittsburgh, Pennsylvania area. The Administrative Assistant will provide high-level administrative support by conducting research, handling information requests and performing clerical functions. Major Job Duties and Responsibilities: Perform general office duties such as ordering supplies, maintaining records management systems, and pe...
Temporary administrative assistant position for a South Hills Certified Public Accounting firm from February 24, 2014 through April 15, 2014. Please send your resume and salary requirements to: Reddinger, Will, Gallagher & Dickert, LLC, Manor Oak II, Suite 110, 1910 Cochran Road, Pittsburgh, PA 15220 Attn: Marlene Knapp, 412-571-2900 extension 111 or email to: *****...
PLUM BOROUGH SCHOOL DISTRICT Immediate Openings - Full-time Speech and Language Pathologist and Administrative Assistant Please refer to our website for more information pertaining to these positions: www.pbsd.k12.pa.us. Deadline: December 2, 2013...
Trans Associates, a traffic and transportation engineering consulting firm, is seeking a full-time Administrative Assistant for its Pittsburgh office located in Robinson Township. Candidates must have: High School diploma 5+ years administrative experience very proficient with Word, Excel, PowerPoint, Outlook good written & verbal communication organized & self-motivated detail-oriented & ability...
Job_Other_Compensation: Up to $28000.00 Job Description: We have an immediate need for an Administrative Assistant in Document Services. This is a rewarding position for a dynamic organization seeking the right individual to provide Administrative and Customer Service support for their team. This individual may schedule meetings in Outlook, take orders and track shipments in Excel, research any sh...
Are you resourceful, creative, & fun? So are we! See for yourself! Franklin Interiors, Pittsburgh's leading full service supplier of office and furniture management services, has an opening for an Operations Administrative Assistant at our Service Center in McKees Rocks. Explanatory Comments: This position is responsible for administrative support of our Operations Service Center and coordination...
Finance Administrative Assistant Part time (18-20 hrs/wk). Minimum 5yrs experience. Responsibilities include: data entry,filing, project man- agement. Must be proficient in Ex- cel and Word. Submit resume and cover letter w/salary requirements to: Controller, Sisters of Divine Pro- vidence, 9000 Babcock Blvd, Allison Park, PA 15101 or email: ***** No phone calls please....
Tracking Code 20133556 Job Description The Administrative Assistant is responsible assisting the National Sales Team. Duties include: Answer incoming phone calls, send faxes and emails. Reprinting of customer invoices on a daily basis and tracking daily sales. Create invoices weekly for individual customer billing, or complete AIA documents for billing. Apply received payments monthly to individua...
We are seeking an executive/ administrative assistant who can execute tasks relating to the management and operations of an international logistics company, a commercial/ residential real estate company and other related entities and investments. This individual would be tasked with managing master calendars, supplier information and contact data, arranging meetings, events, and travel. Daily requ...
Company Confidential
ADMINISTRATIVE ASSISTANT Lennon, Smith, Souleret Engineering, Inc. is seeking candidates for an Engineering Unit Administrative Assistant position. Requirements: 5+ years' experience in a technical field, strong verbal/ written communication skills, proficiency with MS Office software, prepare general and project correspondence, technical reports, specifications and contract documents, answer phon...
Helbling & Associates, Inc. is a retained executive search firm in Wexford, PA (just north of Pittsburgh). Our company is experiencing significant growth – we have had more than 30% increase in sales for each of the past two years – and all signs point to an even better 2013 and what may become the best year in our firm's history. To support our growth, we are looking for a hard-working, detail-or...
Company Confidential
Ambridge, PA, 15003
ADMINISTRATIVE ASSISTANT and/or Paralegal. Five years legal experience, preferrably in civil and criminal areas of law. Knowledge of Word Perfect. Full-time, Mon.-Fri., 8am-5pm. Beginning January 2, 2014. Send hand-written resume to: The Times, Box 6006, Beaver, PA, 15009 or e-mail: *****....
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The NHL and NHL Players' Association reached a tentative deal on a new collective bargaining agreement.
While there has been no confirmation of when the season starts, some reports say there are two possible opening nights for the NHL season: a 50-game schedule beginning on Jan. 15 or, at the latest, a 48-game docket up-and-running on Jan. 19.
Here are some of the main highlights of the tentative agreement (in U.S. dollars):
- The Collective Bargaining Agreement (CBA) will run for 10 years through 2021-22, with an option to terminate the deal after eight years.
- Players receive defined benefit pension plan.
- Owners and players split revenue 50-50 each season, with the players receiving $300 million in deferred "make-whole payments" to ease the transition from previous system.
- A pro-rated salary cap of $70.2-million for the shortened 2012-13 season followed by a salary cap of $64.3-million in 2013-14. The salary floor will be set at $44 million for both years.
- Seven-year limit on free-agent contracts (eight-year limit when a team signs its own player to an extension).
- A maximum salary variance of 35 per cent from year to year, with no more than a 50 per cent total difference between any two seasons in the contract.
- The minimum salary starts at $525,000 this season and reaches $750,000 for the 10th and final year of the agreement.
- Teams can only walk away from a player in salary arbitration who is awarded at least $3.5 million.
- Each team will be given the option of two "amnesty buyouts" that can be used to terminate contracts prior to the 2013-14 season or 2014-15 season. The buyouts will cost two-thirds of the remaining amount on a deal — paid evenly over twice its remaining length — and will count against the players' overall share in revenues, but not the individual team's salary cap.
- Revenue sharing between teams increased to $200 million annually.
- Any player on a one-way contract who plays in the American Hockey League with a salary in excess of the NHL's minimum salary plus $375,000 will have the excess amount charged against his team's salary cap.
- Unrestricted free agency continues to open on July 1.
- The participation of NHLers in future Olympics has yet to be determined. The decision will be made outside of the CBA.
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Houses for sale near The Street, Firle, Lewes BN8
3 bedroom bungalow for sale
The Close, Newhaven, East Sussex BN9A two/three bedroom detached bungalow situated at the head of this small close. Situated about one and a half miles from Newhaven harbour and town centre with ferry port and railway station. Features and benefits include gas central heating, upvc ...
Marketed by David Jordan Estate Agents, BN25. Call 01323 376143
Offers over £675,000
4 bedroom detached house for sale
Mark Cross Lane, Ripe, East Sussex BN8A 17th century Detached period cottage in a superb position with far reaching views and garden extending to 0.75 acre (tbv) | Entrance Hall | 25' Living Room with two bay windows & inglenook feature fireplace | L shaped Well fitted kitchen | Utility ...
Marketed by Winkworth - Lewes, BN7. Call 01273 257212
5 bedroom detached house for sale
The Old School House, Beddingham, Lewes, East Sussex BN8Situated on the edge of Beddingham village lies this stunning five bedroom former School House plus two independent cottages. Beautifully presented with stunning views across the South Downs, the School house is a very attractive property which has ...
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- February 10, 2011
- 1:46 p.m.
- Suggest removal
- Reply to this post
BoCephus writes:
in response to briley84:
Please do not elect this man president! I usually support the Republican Party, but I would vote for Obama before voting for Mitch. (& I really can't stand Obama's political opinions)
If you wouldn't support Daniels, which of the prospective Republican candidates would you support?
I'd have a hard time thinking of somebody better suited for the presidency at this juncture in history than Daniels.
We need a tightwad -- badly.
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Hlove |
DMX Threatens to Beat Up His Jailers
Are African celebertiies arrested moore than White celeberties? -
Rihanna's Injuries -- "Horrific"
HEYChris get ready for the corn holly rump rangers! -
DMX Threatens to Beat Up His Jailers
I'm with you bro #34 he need's protection. He needs anus Trojens. -
"War Machine" Busted for Fighting at Gay Club
Looks like he could suck a golf ball through a fifty foot hose! -
Kanye's Chick -- How Can She Be So Clothesless?!
#45 reterict of black people is their is a Black man deep inside every White people. So you have… -
Cops: "Dirty Bird" Creator Blew Lines Off Toilet
Da White man made me do it! -
"Shot at Love" Star Busted for Alleged Shot at GF
hope he loves dark meat! -
Chris Brown Arrested -- Caught On Tape
Its nice to see how the Kings of Africa Fall, by their own hands! -
Hollywood Dim Sum
She has nice Hooters, something TMZ doesn't relate too! -
Jacko Caught Red-Handed
Hey, jacko, thanks for being a genie pig, for showing us not what to do.


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EngineLabs is the leading online resource for performance engine technology.
We go far beyond covering just the "hardware" used by this fast-paced community, because there's much more to engine technology than new parts. EngineLabs will explore the tactics, rationale and strategy that guide the creative minds who are obsessed with making horsepower. We will explain the "whys" and "hows" of the engine more than the "what" and "where."
You will find in-depth engine theory analysis, comprehensive step-by-step engine buildups and interviews with leading engine builders and engineers. Other regular features include hard-hitting commentary, late-breaking news and entertaining personality profiles in addition to showcasing the hottest and newest performance equipment from the aftermarket and OEMs. We'll also be walking the floor at the major trade shows and trying to sneak into garages at the race track.
Stay in tune with EngineLabs!
Site Staff
Mike MagdaEditor
Mike Magda is a veteran automotive writer with credits in publications such as Racecar Engineering, Hot Rod, Engine Technology International, Motor Trend, Automobile, Automotive Testing Technology and Professional Motorsport World. He was the editor of four national automotive magazines, including Chevy High Performance, and he has authored hundreds of automotive technical briefings. In covering nearly every type of motorsport, Magda has collaborated with many of racing's top engine builders and factory engineers.
Jason ReissContributor
Jason is a freelance editor with two decades of motorsports experience.


text:
- March 26, 2013
- 9:08 a.m.
- Suggest removal
- Reply to this post
Up_North writes:
in response to dontletmedown:
All I have to say about this is, if this was me, my significant other better be educating themselves or finding a job also. It takes two people to pop out a kid and two dumber people to pop one out before they can afford to even support themselves. It is quite simple, if you cannot afford to support yourself, then you cannot support a family.
The only reason I'm making these posts is to get people to think how easy it is to get yourselves into a situation where you are in financial trouble and 401k becomes a low priority. Sometimes, even when you are educated and both spouses are working, things happen. You can be very well prepared to take care of your family, then a job loss happens, or an illness happens.
Again, I'll ask what happens if the two people who popped out a kid were perfectly able to support them when they had them, then life intervenes. Do we hold the same level of contempt of them that we do for those who "pop out a kid befoer they can afford to support even theselves"?
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Can't find what you're looking for? Check out our entire film database.
Tyler Perry's I Can Do Bad All By Myself: Trailer
The trailer for Tyler Perry's I Can Do Bad All By Myself. When Ma...
Posted 2009-07-20 20:27:47
Tags: lionsgate, comedy, drama, tyler perrys can do bad all by myself
Runtime: 2m24s | Views: 11105 | Embeds: 76210
Mr. Nice: Red Band Trailer
The red band promo trailer for Mr. Nice. The life and times of cul...
Posted 2009-07-20 19:03:33
Tags: contender films, biopic, comedy, mr nice
Runtime: 3m26s | Views: 13326 | Embeds: 54678
Clive Barker's Book of Blood: Feature Trailer
This is the frame story for the entire Book of Blood series by Cli...
Posted 2009-07-20 15:54:34
Tags: horror, book, suspense, book of blood
Runtime: 1m46s | Views: 18239 | Embeds: 7736
White On Rice: Trailer
Jimmy (Hiroshi Watanabe, LETTERS FROM IWO JIMA) loves dinosaurs an...
Posted 2009-07-20 15:53:07
Tags: variance films, comedy, hiroshi watanabe, white on rice
Runtime: 2m5s | Views: 8777 | Embeds: 16544
From Mexico with Love: Trailer
The trailer for Roadside Attractions' From Mexico with Love. Telen...
Posted 2009-07-20 15:10:19
Tags: roadside attractions, action, drama, from mexico with love
Runtime: 2m25s | Views: 10749 | Embeds: 35586
Paul: Video Blog - Emmy Noms
Simon Pegg congratulates two of their Emmy nominated cast members ...
Posted 2009-07-20 14:44:26
Tags: universal pictures, comedy, adventure, paul
Runtime: 0m54s | Views: 6132 | Embeds: 285
The Graves: Trailer
The trailer for The Graves. Present day. Arizona. Megan and Abby ...
Posted 2009-07-20 14:36:33
Tags: adventure, thriller, horror, the graves
Runtime: 1m38s | Views: 10816 | Embeds: 20916
Coraline: Featurette - Making Faces
A special behind the scenes featurette from the Coraline 2-Disc Co...
Posted 2009-07-20 14:15:44
Tags: focus features, stop motion, cg, coraline
Runtime: 2m0s | Views: 9934 | Embeds: 1654
Coraline: Featurette - The 360 Shot
A special behind the scenes featurette from the Coraline 2-Disc Co...
Posted 2009-07-20 14:15:11
Tags: focus features, stop motion, cg, coraline
Runtime: 1m3s | Views: 8855 | Embeds: 1313
Funny People: B-Roll II
Second b-roll of two for Funny People. B-roll provides a compilati...
Posted 2009-07-20 14:07:18
Tags: universal pictures, comedy, adam sandler, funny people
Runtime: 3m40s | Views: 8365 | Embeds: 592
Addicted to Clips?
Anchorman 2: The Legend Continues: Brick is Dead
Brick (Steve Carell) shows up to his own funeral.
Posted 2013-12-11 18:35:15
Tags: dreamworks, comedy, franchise, anchorman 2
Runtime: 0m59s | Views: 0 | Embeds: 0
Lionheart: The Lady
Lyon (Jean-Claude Van Damme) gets his first introduction to Cynthi...
Posted 2013-12-10 23:14:46
Tags: universal pictures, action, jean claude van damme, lionheart
Runtime: 1m23s | Views: 2946 | Embeds: 62
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Use this free online banjo tuner to tune up your banjo. This is for a standard 5-string Banjo, in GDGBD tuning. For other methods on how to tune your banjo go to our Banjo Tuning Methods page. If you have a banjo that has six strings it might be a banjo guitar and that is tuned like the guitar. For those of you who have a 4-string banjo, it is tuned the same as the viola or cello in CGDA
Note: For those of you who are beginners and don't understand the tuning of a banjo. The banjo tuning is unique because the last string is actually higher in pitch then the rest of the strings. So for those of you who are wondering whats up with this tuner - it's normal. If you have any questions or problems tuning your banjo post them below and we will try and help you.
Recent Comments on this Page | View All Posts |
this has to to a joke.
the online banjo tuner is located on this page: http://www.get-tuned.com/online_banjo_tuner.php If you have the latest version of Flash installed it will work. If you are trying to access the tuner on Apple products, you will have a hard time getting it to work as Apple chooses not to support Flash objects. mcjoy42, what operating system and web browser are you using? Do you have the latest Flash plugin installed?
hey folks! could some one explain me, how to tune my 5string banjo to an open e minor (hope that´s the right tuning for this song). i want to play "the rocky road to dublin", but i dont know how to tune my banjo. have it since yesterday and need´s a bit help. thx
Tuning for open E minor: 5th string -- e/g (tune down to E or leave at G; either works) 4th string -- E (tuned up 2 frets) 3rd string -- G (leave it alone) 2nd string -- B (leave it alone) 1st string -- E (tuned up 2 frets)
Thank you for your banjo tuner! it helped me a lot to get started, works great! My first logon did not load the tuner, so if you don't see the banjo with the big note keys for each string at the bottom, re-logon. Thank you!
for those of you using an Ipad or any crappy apple product you need flash player to view this and apple does not allow flash on their mobile devices...
Need help getting it on the sg note ll the banjo tuner. Any help
Have spent the past 20 minutes trying to locate the banjo tuner.....it used to be simple, now that I registered it is impossible to even find anything , I click on the banjo, it takes me to an add or another directive and then back to the start, too bad, this used to be a good tuning site, I'll find another way.......
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Memorial Coverage
Watch the memorial ceremony for the late president of South Africa Nelson Mandela. The coverage is provided by SABC-TV.
The Utica Comets have made a point to give back to the community during their inaugural season, and that included a holiday-time visit to the St Luke's Home in New Hartford.
Tonight, the semi-finals of 'The Voice' kicked off with a group performance of the happy-go-lucky 'Best Day of My Life' by American Authors.
Most people from here know that Utica, New York is named after the ancient north African city of Utica, located in what is now Tunisia. Wonder what that Utica looks like?
Forbes has compiled a list of the most overpaid actors for 2013. Hmmmm, who could be on this list?
Watch the memorial ceremony for the late president of South Africa Nelson Mandela. The coverage is provided by SABC-TV.
These days, Kelly Clarkson has one thing on her mind. Babies. Clarkson, who's expecting her first baby this spring, talks baby names, pregnancy and lots of wedding tears.
Globes and angels and stars are fine, but for the folks who like to be a little more imaginative with their Christmas-tree decorations—whether from boredom or budget—we've come up with a list of five unusual ways to help get the creative wheels in your noggin spinning:
So, what will you remember from 2013?


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A sex offender is accused of breaching the terms of court orders more than 30 times by trying to make contact with children.
A sex offender is accused of breaching the terms of court orders more than 30 times by trying to make contact with children.
More than 300 government workers in Northern Ireland are facing a second Christmas under a jobs loss threat.
A van driver was ordered to the ground by two masked men who took his vehicle from Ladymar Walk, west Belfast, at 8.40am yesterday.
The gap between Catholic and Protestant levels of participation in Northern Ireland's workforce is closing, it was revealed.
Half of shoppers expect to borrow money to get through the festive season, with 410 euro (£344) the average debt, a survey for credit unions has revealed.
A lack of access to crucial MI5 intelligence is hampering Garda attempts to find the mole in its ranks who the Smithwick Tribunal says colluded with the IRA in the murder of two RUC officers.
An extra 2,000 reports of domestic abuse were received by police in Northern Ireland this year, it has been revealed.
Police have linked three burglaries in Portadown on Wednesday.
A woman struck by a car on Middlepath Street in east Belfast yesterday was reported to be in a critical condition in hospital last night.
The employer of a father-of-two killed in a freak workplace accident said his death was like losing a family member.
A fisherman grabbed a Tesco manager by the testicles and refused to let go after being stopped after an £800 shoplifting spree, the High Court heard.
A man who fondled himself on the Enterprise train in a carriage where three children were present has been handed a four-month prison sentence.
A District Judge has refused to grant an anonymity application by a solicitor whose client appeared at the Magistrates Court in Londonderry charged with sex offences.
A Belfast man was jailed for three years yesterday for his part in a republican riot following an Orange Order parade.
An independent inquiry into child sexual exploitation in Northern Ireland is powerless to compel organisations to answer questions on potential failings within the care system, its chairwoman has told an Assembly committee.
An extra 2,000 reports of domestic abuse were received by police in Northern Ireland this year, it has been revealed.
A Troubles victims' service designed to pay for counselling and other special needs is to be independently reviewed following serious criticism from some sufferers in Northern Ireland.
A fisherman grabbed a Tesco manager by the testicles and refused to let go after being stopped over an £800 shoplifting spree, the High Court heard today.
Forensic science work in Northern Ireland is being carried out on a shoestring budget, a High Court judge said today.
A Co Londonderry man was crushed between two cars as thieves tried to steal his lorry.
Thousands gather to bid farewell
Key moments in life of former president
Help save lives of babies around the world
Photographs from Belfast, Northern Ireland
Striking images from around the globe
Reader images: Send us your pictures
Hundreds of clowns have paraded to the Basilica of Our Lady of Guadalupe in Mexico City as part of an annual pilgrimage to thank the country's patron saint and to ask for her blessings and continuing protection over the coming year.
The family of one of two British women sentenced to almost seven years in jail for trying to smuggle £1.5 million of cocaine out of Peru has insisted she is innocent.
Two men have been arrested by detectives investigating a failed dissident republican car bomb attack on a shopping centre in Belfast.
Real Madrid and Barcelona are among the seven Spanish clubs the European Commission will charge with alleged state aid today, after a damning indictment of the EC's handling of the case by its independent regulator.
Settle yourself down for some adventures in Bundesliga.
There had been murmurings that he had been tempted to try his hand elsewhere, but Rory Best put all that to bed yesterday by nailing his colours firmly to Ulster and Ireland's mast.
Mark Wahlberg has opened up about his faith, saying it has top priority in his life.
Jennifer Lawrence says she wants to see laws introduced to stop people being called fat on TV.
Katy Perry and John Mayer have been chatting about their relationship in a joint TV interview.


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We are a digital studio specialising in games, apps, websites and social media content. We are based at the Innovation Birmingham Campus. Our mission statement is to make digital products which stand out from the crowd. We develop for all platforms so we can reach audiences wherever they are.
Posted by DigiVoodoo on Oct 26th, 2013
Hey guys,
Firstly - check out this link to sign up for the free pre-alpha demo
That's our new game: #TwinTurbo
Sign up to get involved with the free pre-alpha demo which will be launching shortly.
So what have we been up to recently? We've been writing the script that generates our awesome 3D track pieces (corners, banked corners, loop the loops, corkscrews, jumps and chicanes) in a random, never ending and manic way.
You'll be hurtling along the track at thousands of km/ph twisting, turning jumping and trying to build up a high score!
The hardest bit so far has been ridding this code of bugs. For example at the moment there's a likely chance the track will loop back on itself. Which is awesome if the track is flat as you cross back over your old track. But if there's a loop the loop there you just crash into it - which isn't as fun, is not the players fault and needs to be fixed!
So stay tuned and follow our game page for more news.
And sign up for the free pre-alpha demo of Twin Turbo
Lead Designer for Twin Turbo