text:
Hamburg, 14th February 2012
This compact fun camera is tough as nails and defies water, ice and snow. The Sportsline 62 Dual LCD is an attractively priced digital camera that is immediately ready for action. In the mountains, on a turbulent, drenched boat tour, when the wind is scouring the beach with fine grains of sand, in glorious weather – and even up to 3 m under water, the Sportsline 62 Dual LCD is ready to go everywhere.
Its dual display make perfect self-portraits child's play. No more uncertainty about what the picture shows! Turn the camera to make a self-portrait and use the 1.8" monitor on the front of the camera. Of course you can see all photos on the 2.7" display on the back of the camera too. The new 10 megapixel camera is waterproof up to 3 m under water, dustresistant and takes videos (30 frames per second) in brilliant HD resolution (720p). Thanks to its especially robust body, the sporting fun camera (dimensions: 97.5x61.5x23.5 mm) is also suitable for snorkelling.
The technical equipment is rounded off by the high quality precision lens (F=1:2.8), USB 2.0 high speed interface, 3-second pre-record function and 8x digital zoom. The guaranteed shock resistance up to a height of 1.5 m makes the Sportsline 62 Dual LDC suitable for all outdoor activities. Due to its easy handling, it is especially well-suited for children. Available in the colours pink, orange, blue, green and silver, it is a colourful eye catcher both in and near the water. The power supply is provided by two conventional AAA batteries and SD and SDHC memory cards up to 32 GB can be used as storage media.
Availability and price:
The Sportsline 62 Dual LCD will be available in shops from the end of March in pink, orange, blue, green and silver at a non-binding recommended price of 69.95 euros.
Released for immediate publication.


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After reading other reviews I was expecting the worst. but I was greeted by a congenial receptionist who was very helpful with providing information about the area and where to find things I needed. The room was basic but not bad. I got a good nite's sleep, was comfortable, and it met my needs 100%. I would come back here... More
- Also Known As:
- Red Roof Inn Flushing Hotel Flushing
- Red Roof Inn Flushing Hotel
- Official Description (provided by the hotel):
- Red Roof Inn Flushing is located in the heart of downtown. We are minutes away from USTA National Tennis Center (Home of the US Open), Shea Stadium, downtown Manhattan and LaGuardia Airport. Guests may relax at the Botanical Gardens, Flushing Meadows Park, or enjoy a city tour of Manhattan. ... more less
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- TripAdvisor is proud to partner with Expedia, Orbitz, Priceline, Cheap Tickets, Red Roof Inn, Booking.com, Travelocity, Hotels.com, Agoda, Asiatravel.com Holdings and Tingo so you can book your Red Roof Inn Flushing reservations with confidence. We help millions of travelers each month to find the perfect hotel for both vacation and business trips, always with the best discounts and special offers.

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Chris Paul Shows Up Chinese Street Baller (VIDEO)
Chinese street baller "More Free" decided to try to show up Chris Paul in an exhibition game while CP3 was going through Asia promoting Nike.
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Why you should use RO/DI in Reef Tanks
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Listening key to helping farmers weather drought stress
Farm families may have to cope with the drought's emotional toll for some time, so neighbors, friends, and ag professionals should be aware and supportive, according to a rural health specialist.
Kay Shipman
Published: Oct 8, 2012
"The stress (from drought) can go on for months and the impact be felt for years afterward," said Roberta Schweitzer, former Purdue University nursing professor and an expert in coping with rural stress.
Recently, Schweitzer, a nationally certified trainer for mental health first aid, offered advice to help farmers and their families deal with drought-related stress.
Her early warning signs of a farmer who may be in trouble included changes in normal routine and behavior, declined care for the farmstead or livestock, and more frequent illnesses or accidents.
"When we're stressed, the ability to think slows down; there is a lack of concentration," she said.
Schweitzer said now is "an important time for assessing farmers' emotional state ... They may not say they need help, especially not say it directly."
If an individual indicates he or she is having trouble, Schweitzer's advice is to be supportive and let the person know he or she doesn't have to handle the situation alone. She cautioned not to tell stressed people that everything will be all right.
Schweitzer encouraged "active listening" that focuses on the individual and what is being said. Nodding and repeating information back to the person signals the listener is engaged.
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SALT LAKE CITY — The two women behind a popular gym on 1100 East came out swinging Wednesday against the proposed streetcar extension that would take the new transit line past their front door.
"We live and breathe on this street. We know the functionality of this street, as opposed to some study that somebody did that has no idea how this street thrives," said Eliza James, part owner of Boxing Is For Girls gym.
James contends she and her neighbors first heard about the proposed extension of the Sugar House streetcar line three weeks ago and weren't consulted in the planning stages.
The first phase of the streetcar line is expected to begin operating by the end of the year, carrying passengers between the TRAX stop at 2100 South and Fairmont Park at 1040 East.
About two dozen opponents of the streetcar, mostly with connections to the gym, stood along 1100 East on Wednesday in a small but scrappy protest. They held signs asking Salt Lake City Council members by name to vote against the extension, while others took turns with cellphones to call the council members personally.
"Stan Penfold, we are your people," read one sign. "Kyle LaMalfa, political courage," said another.
James moved up and down the street, alternating between encouraging the protesters, talking to passersby and leading an improvised, outdoor workout for gym participants.
"What we're trying to say today is it's important to see what these council members do with this information," James said. "It brought the community together to fight for our street, but if they don't hear us, it's going to be discouraging. It's going to be a break in the system."
James' business partner, Lori Leighton, said the purpose of Wednesday's demonstration was to ask city officials to listen to the community. Leighton spent the afternoon crossing back and forth across the street, carrying a sign declaring "protect 1100 East."
"It's about the people," she said. "Guys, listen to the people. They don't want their neighborhood disrupted with an unnecessary vanity streetcar."
Many attending the protest said they wouldn't mind if the streetcar continued east along 2100 South, connecting the line to Sugarhouse Park and an area they said might benefit economically from additional development, Leighton added.
As rush-hour traffic crept past the group along the two-lane street, many drivers honked, waved or shouted their approval out open windows. Calls in favor of the streetcar extension were few and far between.
George Chapman, who lives near the gym, said a streetcar would destroy the cozy, quiet neighborhood he enjoys walking through.
"It's not just the construction. It's the congestion that will be caused by the streetcar," Chapman said.
Chapman worries traffic snarls will discourage drivers from coming to 1100 East businesses, such as the Boxing Is For Girls gym. He applauded his neighbors for mobilizing the movement against the streetcar.
"They know how to put up a good fight," he said. "All of this is because of them. I appreciate it so much. They're defending their community."
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Dean Miller Surf Bedding's surf decor is a great addition to any beach house! In our sale section you will find highly discounted beach decor items priced to move. Please read the description very carefully as a lot of these items may only have one unit left, is a discontinued Hawaiian decor design, or even has a manufactures flaw. Yes even we here at Dean Miller make mistakes every so often. We have tried to be as detailed as possible in pointing out why the item(s) are on our sale page, and if you have any questions at all concerning the below items please give us a call or see if a customer service rep is online to answer your concerns. Our surf decor sale page is constantly being updated with new items, and a lot of the beach decor items can move very quickly, so don't be surprised if the Hawaiian décor item is gone next time you come to visit our store. Thanks for checking out our selection of surfing related decor! All items subject to prior sale.
If you have any questions or concerns about our island bedding, please remember you can always phone us at 949.698.6278 or chat with a Dean Miller bedding representative online.
Queen Idle Island Comforter: $120.00 - $60.00
Order online or give us a call at 949.698.6278 if you have any questions about our mystery grab bag of fabric! Scrap fabric box is not whole yards of fabric, it is smaller squares, long skinny pieces left over from the sides of cutting a comforter or duvet, could be wide scrap pieces that were used to make a valance, it is very random. This fabric is best used for trims, maybe making a quilt, stuff like that.
Throw pillows come in all of our great bedding patterns currently offered and are perfect to match your Dean Miller bedding or simply to throw on your couch as home decor decorative pieces. Click image for a larger view. If you have any questions or concerns, please remember you can always phone us at 949.698.6278 or chat online with one of our friendly customer service reps!


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Why spiders?..Why couldn't it be..."Follow the butterflies"?- Ronald Weasley.
Follow the link for more HarryP goodies!
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Publications (262)641.81 Total impact
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ABSTRACT: Arsenic exposure is a significant cause of lung cancer in North America and worldwide. Arsenic-related tumors are structurally indistinguishable from those induced by other carcinogens. Because carcinogens, like tobacco, induce distinctive mutational signatures, we sought to characterize the mutational signature of an arsenic-related lung tumor from a never smoker with the use of whole-genome sequencing. Tumor and lung tissues were obtained from a never smoker with lung squamous cell carcinoma (LUSC), without familiar history of lung cancer and chronically exposed to high levels of arsenic-contaminated drinking water. The Illumina HiSeq-2000 platform was used to sequence each genome at approximately 30-fold haploid coverage. The mutational signature was compared with those observed in previously characterized lung tumors. The arsenic-related tumor exhibited alterations common in LUSC, such as the increased number of copies at 3q26 (SOX2 locus). However, the arsenic-related genome not only harbored a lower number of point mutations, but also had a remarkably high fraction of T>G/A>C mutations and low fraction of C>A/G>T transversions, which is uncharacteristic of LUSCs. Furthermore, at the gene level, we identified a rare G>C mutation in TP53, which is uncommon in lung tumors in general (<0.2%) but has been observed in other arsenic-related malignancies. We generated the first whole-genome sequence of an LUSC from a never-smoker patient chronically exposed to arsenic, and identified a distinct mutational spectrum associated with arsenic exposure, providing novel evidence supporting the hypothesis that arsenic-induced lung tumors arise through molecular mechanisms that differ from those of the common lung cancer.Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 11/2013; 8(11):1451-1455. · 4.55 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Autofluorescence (AF) imaging provides valuable information about the structural and chemical states of tissue that can be used for early cancer detection. Optical scattering and absorption of excitation and emission light by the epithelium can significantly affect observed tissue AF intensity. Determining the effect of epithelial attenuation on the AF intensity could lead to a more accurate interpretation of AF intensity. We propose to use optical coherence tomography coregistered with AF imaging to characterize the AF attenuation due to the epithelium. We present imaging results from three vital tissue models, each consisting of a three-dimensional tissue culture grown from one of three epithelial cell lines (HCT116, OVCAR8, and MCF7) and immobilized on a fluorescence substrate. The AF loss profiles in the tissue layer show two different regimes, each approximately linearly decreasing with thickness. For thin cell cultures (<300 μm), the AF signal changes as AF(t)/AF(0)=1-1.3t (t is the thickness in millimeter). For thick cell cultures (>400 μm), the AF loss profiles have different intercepts but similar slopes. The data presented here can be used to estimate AF loss due to a change in the epithelial layer thickness and potentially to reduce AF bronchoscopy false positives due to inflammation and non-neoplastic epithelial thickening.Journal of Biomedical Optics 10/2013; 18(10):106007. · 2.88 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Although enhancer of zeste homolog 2 (EZH2) has been associated with both non-small cell and small-cell lung cancers (SCLCs), current observations suggest different mechanisms of EZH2 activation and overexpression in these lung cancer types. Globally, SCLC kills 200,000 people yearly. New clinical approaches for SCLC treatment are required to improve the poor survival rate. Given the therapeutic potential of EZH2 as a target, we sought to delineate the downstream consequences of EZH2 disruption to identify the cellular mechanisms by which EZH2 promotes tumorigenesis in SCLC. We generated cells with stable expression of short hairpin RNA targeting EZH2 and corresponding controls (pLKO.1) and determined the consequences of EZH2 knockdown on the cell cycle and apoptosis by means of propidium iodide staining and fluorescence-activated cell sorting, Western blot, quantitative reverse transcriptase-polymerase chain reaction as well as cell viability assessment using methylthiazol tetrazolium assays. We discovered that EZH2 inhibition (1) increased apoptotic activity by up-regulating the proapoptotic factors Puma and Bad, (2) decreased the fraction of cells in S or G2/M phases, and (3) elevated p21 protein levels, implicating EZH2 in cell death and cell-cycle control in SCLC. Our findings present evidence for the role of EZH2 in the regulation of cell cycle and apoptosis, providing a biological mechanism to explain the tumorigenicity of EZH2 in SCLC. Our work points to the great potential of EZH2 as a therapeutic target in SCLC.Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 08/2013; 8(8):1102-6. · 4.55 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: BACKGROUND: Quality of oral screening examinations is dependent upon the experience of the clinician and can vary widely. Deciding when a patient needs to be referred is a critical and difficult decision for general practice clinicians. A device to aid in this decision would be beneficial. The objective of this study was to to examine the utility of direct fluorescence visualization (FV) by dental practitioners as an aid in decision-making during screening for cancer and other oral lesions. METHODS: Dentists were trained to use a stepwise protocol for evaluation of the oral mucosa: medical history, head, neck and oral exam, and fluorescent visualization exam. They were asked to use clinical features to categorize lesions as low (LR), intermediate (IR), or high (HR) risk and then to determine FV status of these lesions. Clinicians made the decision of which lesions to reassess in 3 weeks and based on this reassessment, to refer forward. RESULTS: Of 2404 patients screened over 11 months, 357 initially had lesions with 325 (15%) identified as LR, 16 (4.5%) IR, and 16 (4.5%) HR. Lesions assessed initially as IR and HR had a 2.7-fold increased risk of FV loss persisting to the reassessment appointment versus the LR lesions. The most predictive model for lesion persistence included both FV status and lesion risk assessment. CONCLUSION: A protocol for screening (assess risk, reassess, and refer) is recommended for the screening of abnormal intraoral lesions. Integrating FV into a process of assessing and reassessing lesions significantly improved this model.Journal of Oral Pathology and Medicine 06/2013; · 2.06 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: PURPOSE: To explore whether DNA ploidy of prostate cancer cells determined from archived transrectal ultrasound-guided biopsy specimens correlates with disease-free survival. METHODS AND MATERIALS: Forty-seven failures and 47 controls were selected from 1006 consecutive low- and intermediate-risk patients treated with prostate (125)I brachytherapy (July 1998-October 2003). Median follow-up was 7.5 years. Ten-year actuarial disease-free survival was 94.1%. Controls were matched using age, initial prostate-specific antigen level, clinical stage, Gleason score, use of hormone therapy, and follow-up (all P nonsignificant). Seventy-eight specimens were successfully processed; 27 control and 20 failure specimens contained more than 100 tumor cells were used for the final analysis. The Feulgen-Thionin stained cytology samples from archived paraffin blocks were used to determine the DNA ploidy of each tumor by measuring integrated optical densities. RESULTS: The samples were divided into diploid and aneuploid tumors. Aneuploid tumors were found in 16 of 20 of the failures (80%) and 8 of 27 controls (30%). Diploid DNA patients had a significantly lower rate of disease recurrence (P=.0086) (hazard ratio [HR] 0.256). On multivariable analysis, patients with aneuploid tumors had a higher prostate-specific antigen failure rate (HR 5.13). Additionally, those with "excellent" dosimetry (V100 >90%; D90 >144 Gy) had a significantly lower recurrence rate (HR 0.25). All patients with aneuploid tumors and dosimetry classified as "nonexcellent" (V100 <90%; D90 <144 Gy) (5 of 5) had disease recurrence, compared with 40% of patients with aneuploid tumors and "excellent" dosimetry (8 of 15). In contrast, dosimetry did not affect the outcome for diploid patients. CONCLUSIONS: Using core biopsy material from archived paraffin blocks, DNA ploidy correctly classified the majority of failures and nonfailures in this study. The results suggest that DNA ploidy can be used as a useful marker for aggressiveness of localized prostate cancer. A larger study will be necessary to further confirm our hypothesis.International journal of radiation oncology, biology, physics 05/2013; · 4.59 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: For the first time, the use of fiber-optic color Doppler optical coherence tomography (CDOCT) to map in vivo the three-dimensional (3-D) vascular network of airway segments in human lungs is demonstrated. Visualizing the 3-D vascular network in the lungs may provide new opportunities for detecting and monitoring lung diseases such as asthma, chronic obstructive pulmonary disease, and lung cancer. Our CDOCT instrument employs a rotary fiber-optic probe that provides simultaneous two-dimensional (2-D) real-time structural optical coherence tomography (OCT) and CDOCT imaging at frame rates up to 12.5 frames per second. Controlled pullback of the probe allows 3-D vascular mapping in airway segments up to 50 mm in length in a single acquisition. We demonstrate the ability of CDOCT to map both small and large vessels. In one example, CDOCT imaging allows assignment of a feature in the structural OCT image as a large (∼1 mm diameter) blood vessel. In a second example, a smaller vessel (∼80 μm diameter) that is indistinguishable in the structural OCT image is fully visualized in 3-D using CDOCT.Journal of Biomedical Optics 05/2013; 18(5):50501. · 2.88 Impact Factor -
Conference Proceeding: OCT imaging in chronic obstructive pulmonary disease
SPIE BiOS; 01/2013 -
Conference Proceeding: Correction of autofluorescence intensity for epithelial scattering by optical coherence tomography: a phantom study
SPIE BiOS; 01/2013 - [show abstract] [hide abstract]
ABSTRACT: Long noncoding RNAs (lncRNAs) are a unique class of messenger RNA-like transcripts of at least 200 nucleotides in length with no significant protein-coding capacity. Aberrant lncRNA expression is emerging as a major component of the cancer transcriptome. Here, we sought to determine if differential lncRNA expression is a feature of the human cervical intraepithelial neoplasia (CIN) transcriptome. Sequence data were derived from 16 long serial analyses of gene expression (L-SAGE) libraries constructed from cervical specimens representing mild (CIN1), moderate (CIN2), and severe (CIN3) histopathologic grades of CIN. A novel lncRNA discovery pipeline was developed to query the expression of lncRNAs within the SAGE data sets. A total of 2,230,370 sequence tags were delineated from the 16 SAGE libraries, representing the expression of 367,482 unique tags at varying abundance. Using a novel stepwise filtering strategy, we analyzed the cervical SAGE libraries and identified the expression profiles of 1056 lncRNAs in the human cervix. We present the first lncRNA expression profile derived from nonneoplastic cervical tissue and establish that changes in lncRNA expression do occur in cervical intraepithelial lesions. Our analysis also shows statistically significant aberrant expression of lncRNAs in the 3 CIN grades, suggesting that these unique noncoding RNA transcripts may contribute to the development and progression of precursor lesions. Through the analysis of L-SAGE libraries constructed from cervical specimens, we provide the first lncRNA expression profile of the cervix and demonstrate aberrant expression in early-stage neoplasia.International Journal of Gynecological Cancer 11/2012; 22(9):1557-63. · 1.94 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: To improve ploidy analysis in the detection of high-grade cervical dysplasias by combining it with anti-Ki-67 immunocytochemistry in a double staining procedure to distinguish between cells with abnormal DNA content and normal cycling cells. Cervical cytology specimens from 49 patients with various diagnoses, mostly dysplasias, from a previous study were used. Samples were double stained with Feulgen-thionin and anti-Ki-67 immunocytochemistry. Ki-67-negative cells were noncycling, so nondiploid Ki-67-negative cells were likely truly abnormal cells. The area under the receiver operating characteristic curve for the ability to identify high-grade dysplasias was 0.73 for double staining and 0.74 for thionin-only ploidy analysis on Cytospin specimens. At 90% specificity, sensitivities for double staining and thionin alone were 45% and 32%, respectively, but the difference was not statistically significant. Double staining with Feulgen-thionin and anti-Ki-67 immunocytochemistry does not improve the ability of ploidy analysis of cervical cytology specimens to separate high-grade and low-grade dysplasias, but our insights into the technical aspects of double staining, especially the effects of antigen retrieval, give hope that this technique could be applied to other immunocytochemical stains that would have a greater ability to improve ploidy analysis.Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 10/2012; 34(5):273-84. · 0.60 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: The successful management of oral cancer depends upon early detection, which relies heavily on the clinician's ability to discriminate sometimes subtle alterations of the infrequent premalignant lesions from the more common reactive and inflammatory conditions in the oral mucosa. Even among experienced oral specialists this can be challenging, particularly when using new wide field-of-view direct fluorescence visualization devices clinically introduced for the recognition of at-risk tissue. The objective of this study is to examine if quantitative cytometric analysis of oral brushing samples could facilitate the assessment of the risk of visually ambiguous lesions. About 369 cytological samples were collected and analyzed: (1) 148 samples from pathology-proven sites of SCC, carcinoma in situ or severe dysplasia; (2) 77 samples from sites with inflammation, infection, or trauma, and (3) 144 samples from normal sites. These were randomly separated into training and test sets. The best algorithm correctly recognized 92.5% of the normal samples, 89.4% of the abnormal samples, 86.2% of the confounders in the training set as well as 100% of the normal samples, and 94.4% of the abnormal samples in the test set. These data suggest that quantitative cytology could reduce by more than 85% the number of visually suspect lesions requiring further assessment by biopsy.Journal of Biomedical Optics 08/2012; 17(8):86004-1. · 2.88 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Deregulated cell proliferation is a hallmark of cancer, and Ki67 immunostaining can be used to identify proliferating cells. Evaluation of cell proliferation may have utility as a biomarker of epithelial malignant transformation risk. To date, most analyses of Ki67 staining have been restricted to semiquantitative estimations of the degree of staining or the measurement of the fraction of Ki67-positive cells within the epithelium. We sought to develop a robust, objective means of quantitatively evaluating Ki67 immunostaining for lung precancerous lesions. We quantified the spatial distribution of Ki67-expressing cells within the epithelium by means of (1) a cell-based Voronoi tessellation and (2) a basement membrane-referenced distance transform. This was undertaken in a large cohort of 613 lung biopsy sections representing normal, hyperplasia, squamous metaplasia and mild, moderate and severe dysplasia. For each section 21 features quantifying different aspects of the Ki67 staining were calculated. Intraobserver and inter-observer variation were recorded for a subset of the biopsy sections. We examined the behavior of each feature with respect to histopathological grade. These measures demonstrated that proliferation is generally limited to layers 2, 3 and 4 of the epithelium (layer 1 being the basal layer). The proliferation in the basal layer is limited and does not increase with increasing grade of dysplasia. Interobserver and intraobserver effects on these features were assessed, and several were more robust with respect to measuring Ki67 expression pattern than the commonly used fraction of Ki67-positive cells. Many of these quantitative features showed associations with histological grade that were as strong as the association that exists based on the fraction of Ki67-positive cells while being much more robust to interobserver- and intraobserver-associated variations. The measured spatial distribution of proliferating cells statistically demonstrated asymmetric cell division behavior in cells in the basal layer, a pattern attributed to stem cells giving rise to transient amplifying cells.Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 06/2012; 34(3):120-38. · 0.60 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Optical spectroscopy has been proposed as an accurate and low-cost alternative for detection of cervical intraepithelial neoplasia. We previously published an algorithm using optical spectroscopy as an adjunct to colposcopy and found good accuracy (sensitivity=1.00 [95% confidence interval (CI)=0.92 to 1.00], specificity=0.71 [95% CI=0.62 to 0.79]). Those results used measurements taken by expert colposcopists as well as the colposcopy diagnosis. In this study, we trained and tested an algorithm for the detection of cervical intraepithelial neoplasia (i.e., identifying those patients who had histology reading CIN 2 or worse) that did not include the colposcopic diagnosis. Furthermore, we explored the interaction between spectroscopy and colposcopy, examining the importance of probe placement expertise. The colposcopic diagnosis-independent spectroscopy algorithm had a sensitivity of 0.98 (95% CI=0.89 to 1.00) and a specificity of 0.62 (95% CI=0.52 to 0.71). The difference in the partial area under the ROC curves between spectroscopy with and without the colposcopic diagnosis was statistically significant at the patient level (p=0.05) but not the site level (p=0.13). The results suggest that the device has high accuracy over a wide range of provider accuracy and hence could plausibly be implemented by providers with limited training.Journal of Biomedical Optics 04/2012; 17(4):047002. · 2.88 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Optical spectroscopy devices are being developed and tested for the screening and diagnosis of cancer and precancer in multiple organ sites. The studies reported here used a prototype of a device that uses white light, green-amber light at 545 nm, and violet light at 405 nm. Given that oral neoplasia is rare, the need for a device that increases the sensitivity of comprehensive white light oral screening is evident. Such a device, in the hands of dentists, family practitioners, otorhinolaryngologists, general surgeons, obstetrician gynecologists, and internists, could greatly increase the number of patients who have lesions detected in the precancerous phase. The objective of this study was to present a case series of oral precancers and cancers that have been photographed during larger ongoing clinical trials. Over 300 patients were measured at 2 clinical sites that are comprehensive cancer centers and a faculty practice associated with a major dental school. Each site is conducting independent research on the sensitivity and specificity of several optical technologies for the diagnosis of oral neoplasia. The cases presented in this case series were taken from the larger database of images from the clinical trials using the aforementioned device. Optical spectroscopy was performed and biopsies obtained from all sites measured, representing abnormal and normal areas on comprehensive white light examination and after use of the fluorescence and reflectance spectroscopy device. The gold standard of test accuracy was the histologic report of biopsies read by the study histopathologists at each of the 3 study sites. Comprehensive white light examination showed some lesions; however, the addition of a fluorescence image and a selected reflectance wavelength was helpful in identifying other characteristics of the lesions. The addition of the violet light-induced fluorescence excited at 405 nm provided an additional view of both the stromal neovasculature of the lesions and the stromal changes associated with lesion growth that were biologically indicative of stromal breakdown. The addition of 545 nm green-amber light reflectance increased the view of the keratinized image and allowed the abnormal surface vasculature to be more prominent. Optical spectroscopy is a promising technology for the diagnosis of oral neoplasia. The conclusion of several ongoing clinical trials and an eventual randomized Phase III clinical trial will provide definitive findings that sensitivity is or is not increased over comprehensive white light examination.Gender Medicine 02/2012; 9(1 Suppl):S25-35. · 1.69 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Optical spectroscopy and imaging devices are being developed and tested for the screening and diagnosis of cancer and precancer in multiple organ sites. The aim of the study reported here is to optimize the capability of an optical imaging device to discriminate precancerous tissue from other lesions by identifying ideal excitation wavelengths. The studies reported here used a prototype of a direct fluorescence imaging device that uses 405-nm illumination to excite tissue. There is ample evidence in the literature that 405 nm can distinguish oral cancers from normal tissue. Higher wavelengths may be necessary to differentiate potential confounding lesions, such as abrasions, burns, viral infections, inflammation, and gingivitis. Imaging at 405 nm could help doctors detect precancerous and cancerous oral lesions. Such imaging could be used by dentists, family practitioners, otorhinolaryngologists, general surgeons, obstetrician gynecologists, and internists, and could greatly increase the number of patients who have lesions detected in the precancerous phase.Gender Medicine 02/2012; 9(1 Suppl):S78-82.e1-8. · 1.69 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Optical spectroscopy has been studied for biologic plausibility, technical efficacy, clinical effectiveness, patient satisfaction, and cost-effectiveness. We sought to identify health care provider attitudes or practices that might act as barriers or to the dissemination of this new technology. Through an academic-industrial partnership, we conducted a series of focus groups to examine physician barriers to optical diagnosis. The study was conducted in 2 stages. First, a pilot group of 10 physicians (8 obstetrician gynecologists and 2 family practitioners) was randomly selected from 8 regions of the United States and each physician was interviewed individually. Physicians were presented with the results of a large trial (N = 980) testing the accuracy of a spectroscopy-based device in the detection of cervical neoplasia. They were also shown a prototype of the device and were given a period of time to ask questions and receive answers regarding the device. They were also asked to provide feedback on a questionnaire that was then revised and presented to 3 larger focus groups (n = 13, 15, and 17 for a total N = 45). The larger focus groups were conducted during national scientific meetings with 20 obstetrician gynecologists and 25 primary care physicians (family practitioners and internists). When asked about the dissemination potential of the new cervical screening technology, all study groups tended to rely on established clinical guidelines from their respective professional societies with regard to the screening and diagnosis of cervical cancer. In addition, study participants consistently agreed that real-time spectroscopy would be viewed positively by their patients. Participants were positive about the new technology's potential as an adjunct to colposcopy and agreed that the improved accuracy would result in reduced health care costs (due to decreased biopsies and decreased visits). Although all participants saw the potential of real-time diagnosis, there were many perceived barriers. These barriers included changes in scheduling and work-flow, liability, documentation, ease of use, length of training, device cost, and reimbursement by third-party payers. Barriers exist to the dissemination of optical technologies into physician practice. These will need to be addressed before cervical screening and diagnosis programs can take advantage of spectroscopy-based instruments for cancer control.Gender Medicine 02/2012; 9(1 Suppl):S67-77; quiz 77.e1-6. · 1.69 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Despite the benefits of early lung cancer detection, no effective strategy for early screening and treatment exists, partly due to a lack of effective surrogate biomarkers. Our novel sputum biomarker, the Combined Score (CS), uses automated image cytometric analysis of ploidy and nuclear morphology to detect subtle intraepithelial changes that often precede lung tumours. 2249 sputum samples from 1795 high-risk patients enrolled in ongoing chemoprevention trials were subjected to automated quantitative image cytometry after Feulgen-thionin staining. Samples from normal histopathology patients were compared against samples from carcinoma in situ (CIS) and cancer patients to train the CS. CS correlates with several lung cancer risk factors, including histopathological grade, age, smoking status, and p53 and Ki67 immunostaining. At 50% specificity, CS detected 78% of all highest-risk subjects-those with CIS or worse plus those with moderate or severe dysplasia and abnormal nuclear morphology. CS is a powerful yet minimally invasive tool for rapid and inexpensive risk assessment for the presence of precancerous lung lesions, enabling enrichment of chemoprevention trials with highest-risk dysplasias. CS correlates with other biomarkers, so CS may find use as a surrogate biomarker for patient assessment and as an endpoint in chemoprevention clinical trials.Analytical cellular pathology (Amsterdam) 01/2012; 35(3):187-201. · 0.92 Impact Factor -
Article: Technologies supporting analytical cytology: clinical, research and drug discovery applications.
[show abstract] [hide abstract]
ABSTRACT: The tools and techniques developed for analytical cytology have become invaluable in expanding the development of cancer screening programs and biomarker discovery for personalized medicine. Detecting cellular, molecular, and functional changes of diseased tissue as defined by quantitative analytical methodologies has enhanced the field of medical diagnostics and prognostics. The focus of this review is to outline applications and recent technical advances in flow cytometry, laser scanning cytometry, image cytometry, and quantitative image analysis, as they pertain to clinical, research, and drug discovery applications.Journal of Biophotonics 01/2012; 5(4):313-26. · 3.10 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Recent evidence suggests that the observed clinical distinctions between lung tumors in smokers and never smokers (NS) extend beyond specific gene mutations, such as EGFR, EML4-ALK, and KRAS, some of which have been translated into targeted therapies. However, the molecular alterations identified thus far cannot explain all of the clinical and biological disparities observed in lung tumors of NS and smokers. To this end, we performed an unbiased genome-wide, comparative study to identify novel genomic aberrations that differ between smokers and NS. High resolution whole genome DNA copy number profiling of 69 lung adenocarcinomas from smokers (n = 39) and NS (n = 30) revealed both global and regional disparities in the tumor genomes of these two groups. We found that NS lung tumors had a greater proportion of their genomes altered than those of smokers. Moreover, copy number gains on chromosomes 5q, 7p, and 16p occurred more frequently in NS. We validated our findings in two independently generated public datasets. Our findings provide a novel line of evidence distinguishing genetic differences between smoker and NS lung tumors, namely, that the extent of segmental genomic alterations is greater in NS tumors. Collectively, our findings provide evidence that these lung tumors are globally and genetically different, which implies they are likely driven by distinct molecular mechanisms.PLoS ONE 01/2012; 7(3):e33003. · 3.73 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: For therapeutic purposes, non-small cell lung cancer (NSCLC) has traditionally been regarded as a single disease. However, recent evidence suggest that the two major subtypes of NSCLC, adenocarcinoma (AC) and squamous cell carcinoma (SqCC) respond differently to both molecular targeted and new generation chemotherapies. Therefore, identifying the molecular differences between these tumor types may impact novel treatment strategy. We performed the first large-scale analysis of 261 primary NSCLC tumors (169 AC and 92 SqCC), integrating genome-wide DNA copy number, methylation and gene expression profiles to identify subtype-specific molecular alterations relevant to new agent design and choice of therapy. Comparison of AC and SqCC genomic and epigenomic landscapes revealed 778 altered genes with corresponding expression changes that are selected during tumor development in a subtype-specific manner. Analysis of >200 additional NSCLCs confirmed that these genes are responsible for driving the differential development and resulting phenotypes of AC and SqCC. Importantly, we identified key oncogenic pathways disrupted in each subtype that likely serve as the basis for their differential tumor biology and clinical outcomes. Downregulation of HNF4α target genes was the most common pathway specific to AC, while SqCC demonstrated disruption of numerous histone modifying enzymes as well as the transcription factor E2F1. In silico screening of candidate therapeutic compounds using subtype-specific pathway components identified HDAC and PI3K inhibitors as potential treatments tailored to lung SqCC. Together, our findings suggest that AC and SqCC develop through distinct pathogenetic pathways that have significant implication in our approach to the clinical management of NSCLC.PLoS ONE 01/2012; 7(5):e37775. · 3.73 Impact Factor
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- Thursday 19 December 2013
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MADRID, SPAIN: The Madrilenos' schedule is very different from the average Northern European's, but not as late-night as it was duringthe celebrated Movida period, the swinging times which followed Franco's death in the 1970s. Most people eat at around 10pm, but restaurants stop serving around midnight. There are later-night restaurants, for example the Vips chain, but unlike its sister chain in Mexico City it shuts at three: after that, food comes from the 24-hour shops. Nightlife happens outdoors in the summertime, and Madrid is one of few cities where you will often find yourself in a traffic-jam at 3am. You can start clubbing on Friday evening and run right through to Sunday night: but the Metro shuts at around 1am and night-buses are restricted to a few lines.
MEXICO CITY, MEXICO: Has become dangerous, with 80 per cent of crime attributed to the undercover police. People's fear of being hijacked casts a shadow over street life. None the less, the city is so vast and energetic that there's still adventure to be had. The only truly 24-hour services are the Vips fast-food restaurants, selling good-quality Mexican food, and taco stands called taquerias. Recently the bar scene has taken off, reflecting the obsession with rave culture - but the bars close at two. Discos offer free entrance to women and complimentary drinks, but watch out - locals worry about ice-cubes laced with ether. Another option is dancing salsa at the Salons de Balle, which close at four. Seedier versions, exlusively for men, are the Fricheras where men pay women to dance with them.
LAGOS, NIGERIA: A big, cosmopolitan city based around money and nightlife in all its guises, often compared to New York. Shopping malls shut at 10pm, but almost anything you might want is available throughout the night from hotel boutiques and roadside stalls - there's even a street dedicated to 24-hour tailors. Late-night karaoke is popular at the moment, as are round-the-clock squash, tennis, swimming and libraries; the Shrine, run by Fela Kuti, Nigeria's national musical hero, offers theatrical shows, music and dancers. A few bars have cinema screens, but the pirate-video market cancels out the need for cinemas. For the religiously inclined, particularly the evangelists, churchgoing is on offer round the clock - and witchdoctors are available at most times, if that's your preference.
Nigerians get itchy feet. If they stay in one place, there's a general emphasis on cramming as much as possible into one night and few people wait for the weekend.
PARIS, FRANCE: Parisians' lives are organised around late-night dining and drinking, with lots of 24-hour restaurants where you can drink and talk in the company of Bohemian Paris. Live-music venues closing at around 5am are on the increase, as are late-night kebab shops, supermarkets and grocers. The number of nightclubs and after-hours bars are restricted by draconian licensing laws; although there are 24-hour video-vending machines, late-night cinemas are thin on the ground. A typically Parisian night-time activity is to walk, or indeed rollerblade, along the Seine: the monuments flanking the river appeal to the national sense of romance and pride. The Metro closes at 1.30am, but there are 24-hour buses.
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NCC girls to climb Mount Shitidhar
New Delhi, Sept 9 : National Cadet Corps (NCC) director general Lt Gen PS Bhalla on Monday flagged-off here the NCC Girls Mountaineering Expedition to Shitidhar Peak (17090 Feet) at Manali in Himachal Pradesh.
A total of 18 Senior Wing NCC Girl Cadets will be attempting the peak in the first week of October.
They have been trained extensively on rock climbing, rappelling, search and rescue techniques, snow and ice craft, and crevasse rescue.
The expedition is being led by Lt Col Vishal Dubey.
Capt Deepika Rathore, who was a member of the first Indian Army Lady Officers expedition to scale Mt Everest in 2012, is the deputy leader.
A lady Medical Officer and 15 service personnel will also be accompanying the cadets.
The DGNCC exhorted the young cadets to undertake the challenge with cool courage, professionalism and an indomitable will.
The expedition will provide precious opportunity to the cadets to fathom their physical and mental limits, explore the pristine and serene beauty of the Himalayas, appreciate the bio diversity and delicate ecological issues.
Above all, the mountaineering expedition will empower the young girls to take on more daunting challenges in their lives.
--IBNS (Posted on 10-09-2013)
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David F. Shepard has been appointed national sales manager for
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Corrosive water is a major problem in many areas of the country, causing copper pipe to degrade prematurely. A plumber tells how he installs new domestic piping, using cross-linked polyethylene.


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Kevin Spacey is a Talented Dude
This was just on Reddit. It's a clip from Inside the Actor's Studio from, we think 2000. James Lipton prompts Kevin Spacey to do a bunch of impersonations including Al Pacino, Marlon Brando, Christopher Walken, Clint Eastwood and Jack Lemmon.
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- April 12, 2013
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foshizzle (Inactive) writes:
Speaking of traitors, Ron Paul did that to himself whenever he blamed 9/11 on U.S. foreign policy.
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99 Bricks: The Legend of Gary - A fairytale Tetris using stone blocks. Use the arrows to rotate and move the pieces
Play this game larger
Zombies Smasher Click on cars to start or stop them and smash all zombies.
Category: arcade |
Dead Town Arrow keys to walk, A to fire S to reload. Kill the undead.


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Dosing schedule vs. erratic work life Aug 4, 2003 I will begin treatment next week for the first time. I'll be taking Sustiva & Combivir. My latest number are: VL = 159,000; T cells = 420. I am symptomatic with esophegeal herpes and a skin fungus, and I was recently treated for MRSA with two courses of Linezolid. My question is about taking my new meds on time. My schedule is a little bit erratic. If I start by taking a Combivir at noon, then a Combivir and Sustiva at Midnight, will I have any room to play with the dosing if due to work/driving requirements, I want to take the Midnight dose a couple of hours earlier or later? I'm mainly concerned about the first month of treatment as I understand the dizzyness caused by Sustiva may clear after that time, but in general I need to know if I have a "window", or am I inviting problems by not being exact with my dosing schedule. Thanks. |
Response from Dr. Young
With any antiretroviral medication regimen, the most important issue is taking the pills regularly (not missing doses). There is quite a bit of lee way for the actual hours or timing of doses; I usually tell my patients that a couple of hours around the scheduled 12 hour interval would be fine. With regard to the dizziness side effect of efavirenz, if you find yourself waking with dizziness (or other typical side effects), you could easily take the medication a hour or even two before you go to bed. Good luck. BY | ||||||||||
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text: Results 1–10 of 1682 for "Magazine Article"X related to "All you need is contact" Refine Your Search Refine Your Search TopicEducation (237)Therapy (90)Children (85)Law & psychology (64)Emotional health (54) 48 more... 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From: | lilypond |
Subject: | Re: Issue 935 in lilypond: Enhancement: optional arguments in music functions |
Date: | Wed, 14 Sep 2011 16:25:12 +0000 |
Comment #2 on issue 935 by address@hidden: Enhancement: optional arguments in music functions
http://code.google.com/p/lilypond/issues/detail?id=935Before investing unnecessary work here: is the bounty offer still good or should it be removed from the issue report?
There are some situations where optional arguments would be feasible. The optional argument could, quite in contrast to how Scheme does it, not be the last argument, and it would need to differ in type from the following argument. For example, an optional Scheme argument before a music argument should work. An optional pitch before a music argument would require the music argument to be "closed", delimited. And so on.
Grinding out a reasonable set of combinations that will make it through bison without shift/reduce or reduce/reduce conflicts will be considerable work.
And one has to note that things like \myfunction \withoption #... { }are already possible: \withoption will just be a music function integrating #... into the following music expression in a manner that \myfunction, taking just a single music argument, will be able to use.
So the basic usability boils down to being able to differentiate things like \myfunction #... { } from \myfunction { }.That's limited. It could likely suffice to turn both forms of \relative into a single music function. And a few other things. But it would really cover only a limited set of combinations, and it will take work coaxing those into the grammar (I don't expect the resulting changes to be overly complex, but they'll take a lot of experimentation).
So I'd probably take this on only if there is sufficient interest in the kind of functionality I just sketched. Probably the syntax would be something like
relative = #(define-music-function (parser location pitch music)((ly:pitch? (ly:make-pitch 0 0 0)) ly:music?)
...Namely for optional signature parts, you specify the default when the argument is not given.
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Get a jump-start on your winter wonderland! We've gathered some of our favorite festive baking essentials to introduce some good cheer to your home come December. From cookie cutters and cookbooks to pans, platters and stainless steel bowls, this merry medley makes whipping up the Christmas spirit a snap.
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They say everything old is new again and that's not just for leg warmers and neon … male chest hair is back from the '70s with a vengeance! (The cutesy term for chest hair is "heavage," but that sounds like what happened after I drank four shots of vodka for the first time.) The popularity of deep V-necks and scoop-neck tops in men's fashion is to blame, apparently, and the Wall Street Journal says these clothes plus tufts of man fur offer "blatantly sexual … studly swagger." Keep reading »
Profile for Jessica Wakeman
Look, It's A Push-Up Bra For His Junk!
Finally, we ladies will understand the disappointment men experience while delicately unhooking a lady's bra … and realizing it's a push-up. Fake out! Oh, well. Menfolk looking for help will find that the Shock Jock briefs and boxers by Andrew Christian aid immensely in the cantilevering department. It's got "extreme frontal enhancing technology," which is a fancy way to describe a removable/washable padded cup. (Hmm, I wonder if any men on our "16 famous man bulges" list own a Shock Jock!) But seriously, ladies, do you actually know an American man who would pay $29-$32 for a pair of underpants? Didn't think so. [Shock Jock Brief at Andrew Christian] Keep reading »
Frisky Rant: Men Don't Cheat Because Their Wives Are Ugly
When my high school boyfriend cheated on me, I found out the other girl's Instant Messenger screen name and "confronted" her online. (Not the most mature move, I know. But give me a break! I had just turned 17.) You know what this bitch had the audacity to say to me? "I've seen a picture of you! No wonder he cheated." Owww.
Sadly, that dopey logic is not confined to teenage soccer players who give hickeys to other girls' boyfriends; it has cycled over and over and over in my mind as this alleged Tiger Woods affair has played out. Surely you, like me, have heard numerous friends or significant others say something to the effect of, "How could he have cheated on his wife? She's so gorgeous!" Yes, Elin Nordegren is a freaking blonde-haired Swedish former model and her turd husband allegedly still cheated on her. What I want to know is why we insist a woman's beauty—which is highly subjective!—is some kind of barometer—which is highly shallow!—of whether or not her hubby will cheat. Keep reading »
Today's Lady News: NY Same-Sex Marriage Bill Fails, But Senator Gives An Amazing Speech In Favor
- The District of Columbia legalized same-sex marriage yesterday … [L.A. Times]
- … but today, New York's State Senate voted down a bill to legalize same-sex marriage. Extreme disappointment. The only good thing to come out of the vote was this rousing, passionate, and impressive speech — above — in favor of passing the measure, by NY Senator Diane Savino. It's funny, as well as moving and worth watching all 7.5 minutes. [New York Times]
Georgia Jail Thinks Pink Is For Prisoners
Ben Hill County Jail in Georgia will be undergoing some pretty severe interior decoration soon. So, why do we care? The whole jail will be painted Pepto-Bismol pink on the inside and re-refurbished in the girly hue: pink walls, pink shower curtains, pink bed sheets, pink blankets, even pink handcuffs. I wonder how much that is costing taxpayers.
But why a loud Pepto-Bismol pink, of all colors? Are they trying to torture these prisoners? No, they're trying to shame them. Because, you know, pink is a feminine color. There is no punishment worse than making a man be the slightest bit feminine, apparently. Keep reading »
"Cheetahs," The New Dumbass Label For "Older" Women Who Date
Apparently unaware that women of all ages have always enjoyed robust sex lives, The New York Observer introduces us to "cheetahs." What's a cheetah, you ask? They are 30-something single women — the younger nieces of the 40-something-and-up "cougars" — who are so desperate for sex and affection that they'll prowl the bars, waiting to prey on unsuspecting victims. In fact, cheetahs will basically rape men, they're so overcome by singledom lust!
Today's Lady News: California Prankster Tries To Ban Divorce To Save "Traditional Marriage"
- "Saturday Night Live" has hired another female writer! Jessi Klein is the third person with a vagina (not including performers) to grace the current "SNL" writing team. [The Wrap]—Could it be that Klein was hired in response to criticism by former "Letterman" writer Nell Scovell, who complained in Vanity Fair about nearly all-male comedy show writing staffs?
- John Marcotte, a rabble-rouser with a great sense of humor, is trying to get a measure on California's ballot box to ban divorce to make a statement about same-sex marriage, which was outlawed in 2008 to protect so-called traditional marriage between straights. Marcotte told CBS News, "Since California has decided to protect traditional marriage … it would be hypocritical of us not to sacrifice some of our own rights to protect traditional marriage even more." He has a point! [CBS News]
Wedges That Take Stripper Heels To New Heights!
Someone should tell the craftsman who whittled the lil' pole dancer on these 7″ wedges that stripper heels are usually made of clear plastic. But, hey, whatevs. The $175 price tag on eBay is a steal for such an, um, unique item. (Although we're pretty sure falling off 7″ tall shoes will break your neck.) [Trend de la Creme] Keep reading »
Cocktail Waitress Jaimee Grubbs Also Claims Intimate Knowledge Of Tiger's Wood
Uh oh. It just became an even worse week to be named "Tiger Woods." A 24-year-old L.A. cocktail waitress named Jaimee Grubbs, who appeared on trashy VH1 dating show "Tool Academy," claims she has also boinked the very married golf pro. According to a story on UsMagazine.com, Grubbs claims she and Woods had a two-and-a-half year-long relationship and engaged in 20 sexual encounters. Grubbs also claims to possess 300 text messages from Woods and a condemning voicemail in which Woods says his wife, Elin Nordegren, has discovered their affair. Eeek! But once again: take these rumors with a grain of salt, innocent until proven guilty, fame-hungry bitches, etc., etc. Still, we've got to say, it would seem that between Grubbs and Rachel Uchitel, the woman whom The National Enquirer accused of being "the other woman," Tiger has a thing for party girls, doesn't he? [UsMagazine.com] Keep reading »


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bored of excitement – the griefjunkie blog
Home » Blog » Save Me, Lady Constance
Save Me, Lady Constance
Thursday, June 14th, 2012 at 7:47 pm | Write a comment
The phrase 'Bomb Scare Drill' consists of three unappealing words arranged to describe an unhappy event in an uncomforting manner. We used to have Bomb Scare Drill at school when I was a child, and it involved walking calmly to the playground when the fire bell rang, answering your name as it was read out by a teacher, and then playing truant for the rest of the day. Bomb Scare Drill was also an excuse for teachers to impress the evils of such truancy upon us, by presenting the horror story scenario of telling your old dear that not only had the IRA blown the school up, but that you were missing, presumed detonated. In a great many cases, the parents concerned would simply have said 'Well no, he's upstairs smoking my bloody fags again' or 'I've sent him out shoplifting, he'll be back at six', in order to soothe the jangling nerves of teachers and social workers alike. I thought my social worker was a teacher for several years, and questioned the overall validity of Bomb Scare Drill in the first place, on the grounds that if a bomb had been found in the building, assembling the entire school eight feet away from it was unlikely to do much good. A further irony was that our school was a designated shelter in the event of nuclear war – this was the eighties, remember – and so leaving it because a bomb had been reported seemed illogical.
There are very few of my school reports in existence, but one of them has an exasperated 'Paul is a natural anarchist' as the sole summary of an entire years' study, while another has 'Paul knows how to kiss proper like' in the space where the headmaster's comment had first been carefully erased by Nick Lovell. It is fair to say that I come from a social environment in which academic prowess is not a valued commodity, and this is best illustrated by the fact that I didn't notice Nick's careful editing until discovering the report in the attic at my old dear's house in 2003.
My increasingly optimistic hope that I will marry into money and thereby reverse over two decades of educationless scrabbling about were inflamed recently by Lady Constance Talbot, the Eighth Marchioness of Lothian. I was struck by her portrait at an East Anglian stately home, and had she not died of laryngitis over a century ago, I'd be tempted to go there more often on the off chance of a bit of slap and tickle in the lovely ornamental grounds which she designed. She did loads of other stuff too, such as launching a British warship which immediately sailed into another British warship and sank itself in 1887. Anyway, these days 'marrying into money' in my case just means hooking up with someone who's never been scarred in a chip shop fight, so perhaps I can afford to lower my sights from deceseaced members of the Victorian aristocracy. It would not be the first time I have done so, as we shall see.
While the nearest I ever got to higher education was delivering post to the Slough Campus of Thames Valley University, my adolescence – untroubled as it was by any notion of academic advancement – was marked at one point by Doctor and the Medics' famous cover of Spirit in the Sky. Twelve is a tricky age for anyone, made more so in my case as I found myself enthralled to state of erotic terror by the two backing singers, who appeared to have recently died some kind of sexy death. In adulthood, this probably accounts for my traditionally wary and suspicious disposition during moments of intimacy. Imagine my surprise, then, when I recently came within an ace of getting the phone number of one of them. I am a practical and realistic man, and as such the marriage potential of such a relationship was immediately clear – for a start, being that I would have commenced proceedings in a state of carnal uneasiness, the ravages of old age would be unlikely to have any further detrimental effect. Also, I would imagine it would be difficult to lose general interest in someone who terrifies you. Whether or not I'd fall for the charms of the older, scarier lady remains to be seen, although it could certainly be an interesting evening of chat and horror over a garlic and crucifix pizza, via a clairvoyant. Come to think of it, if I had access to a clairvoyant I'd be highly tempted to be indiscreet with Lady Constance, presenting a moral dilemma I would be unlikely to be able to avoid, being that I've always been something of a girl who can't say no.
Top: One of my favourite traders, The Singing Soap Lady of Greenwich Market. Don't misunderstand this, by the way – the singing is appalling, but is accounted for by a candid and, as it turned out, entirely accurate explanation she once gave me for it, which is that she is mentally ill.
Middle: Jewellery and cufflink box stall I run for John the Boxes at Leadenhall Market on Fridays while he's away on holiday for a few months.
Lower: My old dear at the gin in the Duke of Wellington public house, Toynbee Street, London E1. Despite a scarf which suggests a senior Daphne from Scooby Doo, she was saying 'Of course, you can't just go round their house and put a shotgun through the letterbox these days, can you?' at the moment I took this picture. Vinny the Landlord refers to her respectfully as Mrs Smith and bans swearing during her not infrequent state visits.
2 Comments
Colette Anadin – one of the scary female backing singers – now works as a body double for Cate Blanchet
Brilliant! Well done Colette. I bet she's a right larf. Being in a female singing duo called the Anadin Brothers is excellent, for a start.


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Education issues from pre-school to college and beyond
The Columbus Dispatch - January 14, 2013 03:10 PM
Ohio Dominican University will offer the only fully-bilingual tax-return services in central Ohio to low-to-moderate income residents who speak Spanish.
Accounting students at Ohio Dominican will provide income tax-return preparation assistance to qualified individuals through the Volunteer Income Tax Assistance program -- VITA, for short. VITA offers free tax help to people generally earning no more than $50,000.
"The program is an opportunity for our students to practice what we teach them in the classroom, while learning to be a good citizen and give back to the community," said Bob Osborne, an accounting professor at ODU and VITA program adviser.
The students, usually juniors and seniors, are certified as tax preparers by the Internal Revenue Service. They work under the supervision of faculty members, who are certified public accountants. As part of the program, the students also help people with special credits, including earned income tax credit, child tax credit and credit for the elderly.
In addition to the college students, students from Bishop Watterson High School will participate, Osborne said. Those students will receive one college credit hour and gain service-learning hours.
To make an appointment, call HandsOn Central Ohio at 211 in Franklin County or call 614-221-6766 and ask to speak to the VITA scheduler.
The program is run out of Rooms 201, 202 and 205 of Erskine Hall on ODU's main campus, 1216 Sunbury Rd. It opens on Feb. 20 and runs through April 13 on the following dates:
Since 2007, ODU faculty and students have helped prepare 1,416 tax returns. Last year, 328 tax returns were prepared, saving clients approximately $82,000 in tax-preparation fees.
Ohio State University moved up 11 spaces on Kiplinger's annual list of 100 Best College Values in Public Colleges to No. 26 for in-state students for 2014. Miami University in Oxford came in 44th.
Kiplinger's ranks schools by assessing several values including their admission rate, percentage of students who return for sophomore year, student-faculty ratio and the four-year graduation rate. As far as costs, the magazine looks at sticker prices, financial aid and average debt at graduation.
Among the Big Ten schools, the University of Michigan fared particularly well, moving up five spots to 6th place for in-state students. The University of Wisconsin Madison ranks 8th.
At Ohio State, the total cost for in-state students is $21,135, while the average debt was $26,409. About 53 percent of OSU students graduate within four years. Meanwhile, the total in-state costs at Miami is $25,949, and the average debt is $27,817. Sixty-eight percent of students there graduate within four years.
Bowling Green State University announced today that it is freezing tuition, general fees and room and board for next school year.
"Rising student debt is a concern for everyone right now," Bowling Green State University President Mary Ellen Mazey said in a written statement. "It is our responsibility to help ensure a college education is attainable for current and future BGSU students."
For the 2014-15 academic year, the total in-state tuition and fees at BGSU will remain at $10,606. Out-of-state tuition and fees will stay at $17,914. Room and board will vary depending upon the residence hall and meal plan chosen. But it can be as low as $8,244. Tuition and general fees for in-state undergraduates at the Firelands campus also will remain at an annual rate of $4,930.
In addition, graduate tuition and fees will remain at the current rate of $11,678 for Ohio residents, and $18,986 for nonresidents.
To increase the pipeline of primary-care doctors in Ohio, Otterbein University is partnering with Ohio University to attract high-school students who will start their studies at the liberal-arts school in Westerville before transferring to OU's medical school.
"Through this program, some of the best and brightest students in Ohio can pursue their medical education close to home, with the likelihood that many of them will remain in the region to provide high-quality comprehensive care to address the most pervasive medical needs of our state," said Dr. Kenneth Johnson, executive dean of OU's Heritage College of Osteopathic Medicine.
Experts project there will be a national shortage of 45,000 primary-care physicians within the next decade, with residents in rural and inner city areas of Ohio feeling the greatest pinch. Officials say Ohio University's Heritage College is well poised to meet the demands because roughly 50 percent of its alumni practice in primary care and nearly 60 percent stay in the state.
Students accepted into Otterbein's new "early assurance program will have two options. They can take three years at Otterbein and graduate early before moving to Ohio University's medical school for another four years or they can take four years at Otterbein, then move to OU for medical school.
Facility would be used for disaster recovery