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Publications (96)528.89 Total impact
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ABSTRACT: Background. Epstein-Barr virus (EBV) plays a major role in the development of post-transplant lymphoproliferative disorder (PTLD), but there is an increasing awareness of EBV-negative PTLD. The clinical presentation of EBV-negative PTLD has not been as well characterised as EBV-positive cases. Further, there is limited knowledge on the clinical importance of diffuse large B-cell lymphoma (DLBCL) cell of origin subtype post-transplant. Materials and methods. We studied the role of EBV, hepatitis C (HCV) and DLBCL subtype in clinical presentation and survival in 135 post-transplant lymphomas diagnosed 1980-2006 in a population-based cohort of 10 010 Swedish solid organ transplant recipients. The lymphomas were re-evaluated according to WHO 2008, examined for EBV, and clinical data were collected from medical records. Results. Lymphoma incidence rate was 159/100 000 person-years and is also reported by lymphoma subtype. EBV-negative lymphomas constituted 48% and were associated with HCV infection (p = 0.02), bone marrow involvement (p < 0.001), and T-cell phenotype (p = 0.002). Among DLBCL, 78% were of non-germinal centre subtype, which was associated with EBV-positivity (69%, p = 0.001), early occurrence (p = 0.03), heart/liver/lung/pancreas recipients (p = 0.02), anti-T-cell globulin (p = 0.001), and tacrolimus treatment (p = 0.02). DLBCL subtypes had similar overall survival. Five-year overall survival was 42% in all treated patients. Independent poor prognostic factors were older age, B symptoms, ECOG 2-4, kidney/pancreas/heart recipients, T-cell lymphoma, and HCV-infection. Conclusions. With long follow-up, a large part of PTLD is EBV-negative, due to a high proportion of T-cell lymphomas and low of polymorphic PTLD. EBV-negative PTLD have a different clinical presentation. HCV may play an aetiological role in late-onset PTLD and was revealed as a new prognostic factor for inferior survival that needs to be confirmed in larger studies. The heavier immunosuppression in non-kidney transplantations seems to play a role in the development of non-germinal centre DLBCL. DLBCL cell of origin subtype lacks prognostic importance in the transplant setting.Acta oncologica (Stockholm, Sweden) 10/2013; · 2.27 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: DNA repair mechanisms are fundamental for B cell development, which relies on the somatic diversification of the immunoglobulin genes by V(D)J recombination, somatic hypermutation, and class switch recombination. Their failure is postulated to promote genomic instability and malignant transformation in B cells. By performing targeted sequencing of 73 key DNA repair genes in 29 B cell lymphoma samples, somatic and germline mutations were identified in various DNA repair pathways, mainly in diffuse large B cell lymphomas (DLBCLs). Mutations in mismatch repair genes (EXO1, MSH2, and MSH6) were associated with microsatellite instability, increased number of somatic insertions/deletions, and altered mutation signatures in tumors. Somatic mutations in nonhomologous end-joining (NHEJ) genes (DCLRE1C/ARTEMIS, PRKDC/DNA-PKcs, XRCC5/KU80, and XRCC6/KU70) were identified in four DLBCL tumors and cytogenetic analyses revealed that translocations involving the immunoglobulin-heavy chain locus occurred exclusively in NHEJ-mutated samples. The novel mutation targets, CHEK2 and PARP1, were further screened in expanded DLBCL cohorts, and somatic as well as novel and rare germline mutations were identified in 8 and 5% of analyzed tumors, respectively. By correlating defects in a subset of DNA damage response and repair genes with genomic instability events in tumors, we propose that these genes play a role in DLBCL lymphomagenesis.Journal of Experimental Medicine 08/2013; · 13.21 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Non-Hodgkin lymphoma represents a diverse group of blood malignancies, of which follicular lymphoma (FL) is a common subtype. Previous genome-wide association studies (GWASs) have identified in the human leukocyte antigen (HLA) class II region multiple independent SNPs that are significantly associated with FL risk. To dissect these signals and determine whether coding variants in HLA genes are responsible for the associations, we conducted imputation, HLA typing, and sequencing in three independent populations for a total of 689 cases and 2,446 controls. We identified a hexa-allelic amino acid polymorphism at position 13 of the HLA-DR beta chain that showed the strongest association with FL within the major histocompatibility complex (MHC) region (multiallelic p = 2.3 × 10(-15)). Out of six possible amino acids that occurred at that position within the population, we classified two as high risk (Tyr and Phe), two as low risk (Ser and Arg), and two as moderate risk (His and Gly). There was a 4.2-fold difference in risk (95% confidence interval = 2.9-6.1) between subjects carrying two alleles encoding high-risk amino acids and those carrying two alleles encoding low-risk amino acids (p = 1.01 × 10(-14)). This coding variant might explain the complex SNP associations identified by GWASs and suggests a common HLA-DR antigen-driven mechanism for the pathogenesis of FL and rheumatoid arthritis.The American Journal of Human Genetics 06/2013; · 11.20 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Diffuse large B cell lymphoma (DLBCL) is a heterogeneous group of B cell lymphomas. MicroRNA expression provides a new and interesting tool for understanding the biology and clinical course of DLBCL. The present study presents microRNA-129-5p expression data from DLBCL patients treated with CHOP or R-CHOP. Patients with low microRNA-129-5p expression had a median survival of 23 months and a significantly shorter overall survival (P = 0.0042) compared to patients with high microRNA-129-5p expression, who had a median survival of 58 months. We also found that patients treated with R-CHOP only and displaying low microRNA-129-5p expression had a significantly shorter overall survival compared to patients with high microRNA-129-5p expression; all such patients were still alive at the time of last follow-up (P = 0.043). No significant difference was found among microRNA-129-5p expression in tumor tissue, the tissue surrounding the tumor, and normal controls. To our knowledge, this is the first report to show that the expression of microRNA-129-5p can affect the clinical outcome of DLBCL patients and that microRNA-129-5p may be involved in the biology of DLBCL development, although larger studies are necessary to confirm this. Further investigations may also help to elucidate the biological role of microRNA-129-5p in DLBCL.International journal of hematology 03/2013; · 1.17 Impact Factor - Journal of Clinical Oncology 02/2013; · 18.04 Impact Factor
Article: High expression of microRNA-200c predicts poor clinical outcome in diffuse large B-cell lymphoma.
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ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas. A new and important tool for understanding the biology and clinical course of DLBCL is microRNA expression. This study presents microRNA-200c expression data from 61 DLBCL patients treated with CHOP or R-CHOP. Patients with high microRNA-200c expression had a median survival of 20.3 months and a significantly shorter overall survival (P=0.019) compared to patients with low microRNA-200c expression, who had a median survival of 35.8 months. We also found that patients treated with R-CHOP only and displaying high microRNA-200c expression had a significantly shorter overall survival compared to patients with low microRNA-200c expression, where all patients were still alive at the time of the last follow-up (P=0.0036). Lastly, we found that patients with high microRNA-200c expression had a significantly shorter time from initial diagnosis to the first relapse compared to patients with low microRNA-200c expression (P=0.0001). To our knowledge, this is the first study showing that the expression of microRNA-200c affects the clinical outcome of DLBCL patients, and that microRNA-200c is involved in the biology of DLBCL development, although larger studies are necessary to confirm this. Further investigations may also help to elucidate the biological role of microRNA-200c in DLBCL.Oncology Reports 12/2012; · 2.30 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Cernunnos is involved in the nonhomologous end-joining (NHEJ) process during DNA double-strand break (DSB) repair. Here, we studied immunoglobulin (Ig) class switch recombination (CSR), a physiological process which relies on proper repair of the DSBs, in B cells from Cernunnos-deficient patients. The pattern of in vivo generated CSR junctions is altered in these cells, with unusually long microhomologies and a lack of direct end-joining. The CSR junctions from Cernunnos-deficient patients largely resemble those from patients lacking DNA ligase IV, Artemis, or ATM, suggesting that these factors are involved in the same end-joining pathway during CSR. By screening 269 mature B cell lymphoma biopsies, we also identified a somatic missense Cernunnos mutation in a diffuse large B cell lymphoma sample. This mutation has a dominant-negative effect on joining of a subset of DNA ends in an in vitro NHEJ assay. Translocations involving both Ig heavy chain loci and clonal-like, dynamic IgA switching activities were observed in this tumor. Collectively, our results suggest a link between defects in the Cernunnos-dependent NHEJ pathway and aberrant CSR or switch translocations during the development of B cell malignancies.Journal of Experimental Medicine 02/2012; 209(2):291-305. · 13.21 Impact Factor - Haematologica 02/2012; 97(2):e3; author reply e4. · 5.94 Impact Factor
- Blood 10/2011; 118(16):4489. · 9.06 Impact Factor
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ABSTRACT: Objective: Classical Hodgkin's lymphoma (HL) lesions comprise few tumour cells, surrounded by numerous inflammatory cells. Like in other malignancies, the microenvironment is presumed to be clinically important in HL; however, microenvironment predictors remain poorly characterised. The aim of this study was to investigate how selected patient characteristics and genetic factors affect HL phenotype, in particular tissue eosinophilia, mast cell counts and HL histological subtype.Methods: In a population-based study, patients with HL were interviewed about potential HL risk factors. Available tumours, n = 448, were classified histologically; the number of eosinophils and mast cells were estimated, and eosinophil cationic protein (ECP) and eosinophil protein-x (EPX) gene polymorphisms were determined. Associations were assessed in regression models.Results: Self-reported history of asthma was predictive of having tumour eosinophilia [≥200 eosinophils/10 high power fields, univariate odds ratio (OR) = 2.22, 95% CI 1.06–4.64, P = 0.03]. High numbers of eosinophils were predominantly seen in patients carrying the genotype ECP434GG [multivariate relative levels (RLs) = 1.84, 95% CI 1.02–3.30, P = 0.04]. Lower number of eosinophils was seen in Epstein–Barr virus (EBV)-positive tumours (univariate RL = 0.52, 95% CI 0.3–0.9, P = 0.02) and in older patients (univariate RL = 0.85, 95% CI 0.73–0.99, P = 0.03). Well-known factors such as young age, female sex and EBV-negative status predicted nodular sclerosis histology.Conclusion: The number of eosinophils in HL tumours is influenced by patient traits such as asthma, ECP genotype and EBV status. EBV status was predictive of histology.European Journal Of Haematology 07/2011; 87(3):208 - 216. · 2.55 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: In Hodgkin lymphoma (HL), tumor eosinophilia indicates poor prognosis, probably caused by eosinophil-induced stimulation of tumor cells. Our aim was to investigate the effects of eosinophil cationic protein (ECP) on HL tumor cells in vitro. A fluorometric microculture cytotoxicity assay was used to measure the survival index of cells from the HL cell lines: HDLM-2 (T-cell origin, nodular sclerosis histology), KMH2 (B-cell origin, mixed cellularity), and L428 (B-cell origin, nodular sclerosis) after incubation with ECP97arg variants with different glycosylations and with ECP97thr. Flow cytometry monitored the effects of ECP on markers of cell death. For KMH2 and L428, ECP was cytotoxic with a dose-response relationship similar to a previously investigated small-cell lung cancer cell line. HDLM-2 was more sensitive to ECP at low concentrations, but reached a plateau (survival index of 70%) at 0.018 μM. The IC(50) for KMH2 and L428 were 0.2 and 0.15 μM, respectively. The IC(50) was never reached for HDLM-2. All tested ECP variants displayed similar activity in HDLM-2, in contrast to KMH2 and L428, which were more sensitive to less glycosylated ECP. Positive DNA staining (propidium iodide) of HDLM-2 cells treated with ECP indicated cell death by necrosis. ECP is cytotoxic for HL tumor cells even at low concentrations, but heterogeneity between cell lines exists and not all tumor cells are eradicated. Two cell lines of B-cell origin, KMH2 and L428, were sensitive to ECP in a dose-response manner, but for HDLM-2, which is of T-cell origin, the cytotoxicity reached a plateau.Experimental hematology 05/2011; 39(8):850-8. · 3.11 Impact Factor - British Journal of Haematology 04/2011; 154(5):661-3. · 4.94 Impact Factor
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ABSTRACT: Cytotoxic CD4(+) T cells have been found in patients with chronic lymphocytic leukaemia (CLL) and seem to be involved in the regulation of malignant B cells. The CD4(+) T regulatory cells (Tregs) can regulate various immune cells, including B cells, by inducing their apoptosis. Hence, different subgroups of CD4(+) T cells may be involved in the regulation of malignant B cells. In this study, the cytotoxic phenotype and function of various CD4(+) T-cell subgroups were investigated in patients with B-cell malignancies. Peripheral blood was collected from patients with CLL, various B-cell lymphomas, healthy adult donors, children with precursor B-cell acute lymphoblastic leukaemia (pre-B ALL) and from healthy children. CD4(+) T cells (CD3(+) CD4(+) FoxP3(-)), Tregs (CD3(+) CD4(+) CD127(low) FoxP3(+)) and CD127(high) FoxP3(+) T cells (CD3(+) CD4(+) CD127(high) FoxP3(+)) were analysed for their expression of the cytolytic markers CD107a and Fas ligand. Patients with CLL had increased CD107a expression on all tested T-cell subgroups compared with healthy donors. Similar results were found in patients with B-cell lymphomas whereas the CD107a expression in children with pre-B ALL was no different from that in healthy controls. Fas ligand expression was similar between patient cells and cells of healthy donors. CD4(+) T cells and Tregs from patients with CLL and healthy donors were subsequently purified and cultured in vitro with autologous B cells. Both subgroups lysed B cells and killing was confirmed by granzyme ELISAs. In conclusion, cytotoxic populations of CD4(+) T cells, including Tregs, are present in patients with B-cell malignancy and may be an important factor in immune-related disease control.Immunology 04/2011; 133(3):296-306. · 3.71 Impact Factor - Leukemia & lymphoma 02/2011; 52(6):1146-9. · 2.40 Impact Factor
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ABSTRACT: TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of the newly diagnosed patients in our cohort thereby carried TP53 mutations without 17p-deletion, a frequency that is much lower than previous reports on referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL onset and instead may arise during disease progression.Leukemia research 02/2011; 35(2):272-4. · 2.36 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: Interleukin-2 (IL-2) is one of the most studied cytokines driving T-cell proliferation, activation and survival. It binds to the IL-2 receptor consisting of three chains, the α (CD25), β and common γ (γc). The binding of the CD25 chain to IL-2 is necessary to expose high-affinity binding sites for the β and γc chains, which, in turn, are responsible for downstream signalling. A high level of soluble CD25 (sCD25) has been associated with a poor prognosis in patients with non-Hodgkin's lymphoma. The function and source of origin of this soluble receptor is not well investigated. In the present study we hypothesized that T regulatory (Treg) cells may release CD25 to act as a decoy receptor for IL-2, thereby depriving T-effector cells of IL-2. Peripheral blood from patients with B-cell malignancies (n = 26) and healthy controls (n = 27) was investigated for the presence and function of FoxP3(+) Treg cells and sCD25 by multi-colour flow cytometry and enzyme-linked immunosorbent assay. Further, the proliferative capacity of T cells was evaluated with or without the presence of recombinant sCD25. The results demonstrate that Treg cells from patients had lower CD25 expression intensity and that they released CD25 in vitro. Further, high levels of Treg cells correlated with sCD25 plasma concentration. Recombinant sCD25 could suppress T-cell proliferation in vitro. In conclusion, the release of sCD25 by Treg cells may be a mechanism to deprive IL-2 and thereby inhibit anti-tumour T-cell responses.Immunology 11/2010; 131(3):371-6. · 3.71 Impact Factor - [show abstract] [hide abstract]
ABSTRACT: The p16(INK4a) tumor suppressor gene can be inactivated by a variety of events including promoter hypermethylation. In diffuse large B-cell lymphoma (DLBCL), p16(INK4a) methylation has been associated with advanced disease stage and higher IPI. The prognostic impact of p16(INK4a) methylation in DLBCL remains unclear; however, it has been suggested to correlate with inferior outcome. To further investigate the clinical impact of p16(INK4a) methylation in DLBCL, promoter methylation of this gene was assessed quantitatively by pyrosequencing. Forty-two of 113 (37%) DLBCL patients with methylation level above 5% were categorized as methylated and subsequently divided into low, intermediate and high methylation categories. Overall, no association was shown between the extent of p16(INK4a) methylation and patients' clinical characteristics, except disease stage (P=0.049). Moreover, we could not reveal any impact of p16(INK4a) methylation on lymphoma-specific survival. Although >25% of p16(INK4a) methylation correlated with a better progression-free survival (P=0.048) in patients <65 years old, the significance of this finding, if any, needs to be further investigated. In conclusion, our finding questions the role of p16(INK4a) promoter methylation as a negative prognostic factor in DLBCL.Leukemia research 10/2010; 35(4):438-43. · 2.36 Impact Factor - Leukemia & lymphoma 08/2010; 51(8):1563-6. · 2.40 Impact Factor
- British Journal of Haematology 07/2009; 146(6):683-4. · 4.94 Impact Factor
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ABSTRACT: Benefits and risks of corticosteroid treatment in rheumatoid arthritis (RA) are debated. Patients with RA are at increased risk of malignant lymphomas. In a large case-control study of risk factors for lymphoma in RA, it was recently reported that steroid treatment was associated with decreased lymphoma risk. To further assess the nature of the association between steroid treatment in RA and the risk of lymphoma. In a cohort of 74 651 patients with RA, 378 patients with lymphoma and 378 matched RA controls were identified, and information on inflammatory activity and different aspects of steroid treatment (duration, therapeutic strategy and mode of administration) abstracted from their medical records. Lymphomas were reclassified (WHO classification) and examined for Epstein-Barr virus. Relative risks were assessed as adjusted odds ratios (ORs) through conditional logistic regression. A total duration of oral steroid treatment of <2 years was not associated with lymphoma risk (OR=0.87; 95% CI 0.51 to 1.5), whereas total treatment >2 years was associated with a lower lymphoma risk (OR=0.43; 95% CI 0.26 to 0.72). RA duration at the initiation of oral steroids did not affect lymphoma risk. Intra-articular steroids were associated with a reduced lymphoma risk, but only when used as swift flare treatment (OR=0.22; 95% CI 0.13 to 0.37). Analyses by lymphoma subtype showed a reduced risk of diffuse large B-cell lymphoma (crude OR=0.59; 95% CI 0.37 to 0.94). In this RA population, use of steroids was associated with reduced lymphoma risk. Whether this association is a generic effect of steroids or specific to the studied population remains unknown.Annals of the rheumatic diseases 06/2009; 69(4):654-9. · 8.11 Impact Factor
Top Journals
Uppsala University
- • Department of Immunology, Genetics and Pathology
- • The Rudbeck Laboratory
Uppsala, Uppsala, Sweden
Uppsala University Hospital
- • Department of Rheumatology
- • Department of Oncology
Uppsala, Uppsala, Sweden
Karolinska University Hospital
Tukholma, Stockholm, Sweden
University of Porto
- Institute of Molecular Pathology and Immunology (IPATIMUP)
Porto, Distrito do Porto, Portugal -
Akademiska Sjukhuset
Uppsala, Uppsala, Sweden -
Karolinska Institutet
- Institutionen för medicin, Huddinge
Solna, Stockholm, Sweden


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- Obama's regulatory agenda will cost U.S. economy $143B next year: report
- Patriot Act author on James Clapper: Fire, prosecute him
- Russia P.M. Medvedev: No amnesty for political prisoners
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- Christmas, by Congress: Members mull a 15-cent tax on trees
- U.S. unemployment falls to five-year low of 7 percent; 203K jobs added
- World mourns Nelson Mandela and celebrates his life; burial set for Dec. 15
- Bill O'Reilly reminds: Nelson Mandela 'was a communist'
- John Boehner says GOP should support gay candidates: 'I do'
- Grass-Whopper: Pan-fried cricket burgers go over big in New York City
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Topic - mexican army
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Feds target contacts of DEA agent's killer
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The Mexican government is telling migrants driving home for the holidays that they should form convoys for their own safety while traveling through Mexico.


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Jon Hamm and Rebecca Hall – The Town on Wed, Jul 14, 2010 | By Sasha Stone JustJared posted some Jon Hamm/Rebecca Hall eye candy snaps from W Magazine. ¬†The subject is the new Ben Affleck film The Town: Jon on¬†The Town: 'ÄúIt'Äôs an adult movie. Those are in short supply. I hope that there'Äôs still an audience for that kind of film, where you can go and see adults behaving like adults.'Äù (more…) 9 READ MORE
"I Just Don't Get It" – The Critics and Inception on Wed, Jul 14, 2010 | By Sasha Stone As various critics annoyingly yet predictably rip Inception apart one has to yet again marvel at the silly way a film is brought down the pike, Oscar-wise. It is as fun and easy to make fun of critics as it is fun and easy to write a bad review about a great film. ¬†I've seen it again and again, year after year, only to discover that Lo! The films the critics were so hot and heavy for are non-starters for lasting impact while the ones they trashed often go on to be heralded as some of the best films released in a given decade. (more…) 103 READ MORE
Can someone please help Rex Reed set the clock on his VCR? on Wed, Jul 14, 2010 | By Ryan Adams Can a critic who headlines his column by asking, "Can Someone Please Explain Inception to Me?" really be capable of reviewing it? About Christopher Nolan, T-Rex says this: "He's got vision, but creating jigsaw puzzles nobody can figure out… doesn't seem like much of an accomplishment to me." You know, my grandmother would be baffled if she tried to use an iPhone. That doesn't mean it's not an impressive accomplishment (well, at least the 3G was). Some things are beyond Rex Reed's comprehension, fine. That's why I'd pass up his explanations of string theory and female orgasms in favor of smarter authorities who might have a firmer grasp of those topics. So what's the value of his Inception analysis for me? About the same value the movie has for him. None. Sorry, but "I don't get it" doesn't cut it. That's a worthless opinion and a pathetic excuse for a review. (more…) 50 READ MORE
It's Kind of a Funny Story, trailer on Wed, Jul 14, 2010 | By Ryan Adams From co-writer/directors Anna Boden & Ryan Fleck, the husband and wife team who gave us Half Nelson and the remarkable, under-appreciated Sugar. Since the trailer lays out the situation so clearly and economically the official synopsis isn't really necessary, but it's included after the cut as an easy way to name the cast. (more…) 15 READ MORE
Life During Wartime, official trailer on Tue, Jul 13, 2010 | By Ryan Adams As we've noted in previous posts, Life During Wartime picks up the plot threads that were left in shredded at the end of Happiness 12 years ago, and weaves the unraveled lives into new patterns of evolving relationships. All the roles are played by new cast members, so it might be interesting to take a look at how they match up, Then and Now. The character roster for this quasi-sequel eliminates all the surnames (so Joy Jordan is now simply Joy; Bill Maplewood now goes by Bill, just Bill). Whether this has any significance in understanding the roles as something more abstract and universal is just one of the fascinating aspects to consider as electrical arcs spark between the two movies. Jane Adams …………….. Joy Jordan ………… Shirley Henderson Jon Lovitz …………….. Andy Kornbluth ………… Paul Reubens (?)* Philip Seymour Hoffman ….. Allen …………….Michael K. Williams Dylan Baker ………….. Bill Maplewood ………….. Ciar√°n Hinds Lara Flynn Boyle ……… Helen Jordan ……………Ally Sheedy Justin Elvin ………….. Timmy Maplewood ……. Dylan Riley Snyder Cynthia Stevenson …. Trish Maplewood ……….. Allison Janney Lila Glantzman-Leib .. Chloe Maplewood ……….. Emma Hinz Rufus Read ………….. Billy Maplewood ……… Chris Marquette Louise Lasser …………. Mona Jordan …………. Ren√©e Taylor ………………………………Jacqueline …………..Charlotte Rampling ………………………………Waitress ………………. Rosalind Ruff ………………………………..Harvey ……………… Michael Learner …………………………………Mark ………………….. Rich Pecci Ben Gazzara ………….. Lenny Jordan Molly Shannon …………… Nancy *(Not sure if all characters with the same name are the same individuals.) 12 READ MORE
Seniority earns Betty White's promotion to God on Tue, Jul 13, 2010 | By Ryan Adams Betty White may be set to step into the Big Corner Office in the Sky previously occupied by George Burns in the 1977 comedy, Oh, God! Jerry Weintraub produced the original directed by Carl Reiner, and Weintrab is working with Warners to reboot with a heavenly gender swap. Paul Rudd would take on the former John Denver role. (Deadline) 6 READ MORE
Oprah bio-pic in the works? on Tue, Jul 13, 2010 | By Ryan Adams Oprah Winfrey's 25-year reign on daytime TV ends when she steps down in September 2011. Her departure could coincide with a TV dramatization of her life story that is most definitely not being done with Winfrey's seal of approval. THR has details: Veteran producer Larry A. Thompson said Monday the planned two- or four-hour Winfrey film will be based on Kitty Kelley's tell-all biography. Thompson says he has optioned it for six figures. Thompson has produced TV biopics about Lucille Ball and Desi Arnaz, and Sonny and Cher. He calls himself "a huge fan" of Winfrey and says he's shopping the project to networks he declined to specify. An unknown will likely be cast to play Winfrey. Good luck to the actress who tackles this role without Oprah's blessing, but it's never too soon to begin idle casting speculation. Viola Davis? 15 READ MORE
9 pivotal gay sex scenes on Mon, Jul 12, 2010 | By Ryan Adams Inspired by by the Best Actress-on-Best Actress action in The Kids Are All Right, Salon tries to list 9 milestone moments in gay-themed movies — and fails. My Beautiful Laundrette (1985) Personal Best (1982) The Rocky Horror Picture Show (1975) Brokeback Mountain (2005) Cruising (1980) Bound (1996) Mulholland Drive (2001) Threesome (1994) Wild Things (1998) First of all, Cruising belongs on this list about as much as I Now Pronounce You Chuck and Larry. (How is it that William Friedkin directed two of the crudest gay movies of all time? Cruising and Boys in the Band.) And those last two Salon picks are just lame and prurient. How about the tenderness of Beautiful Thing or Edge of Seventeen? How about the steamy complexity of Gar√ßon Stupide, Jossi & Jagger or Burnt Money? Hasn't Salon seen Gia or Lost and Delirious? Which of your favorite gay movie sex scenes did Salon miss? 98 READ MORE
Angelina Jolie talks films in development on Mon, Jul 12, 2010 | By Ryan Adams MTV asks Angelina Jolie about several projects to which her name is "attached." Tim Burton's Maleficent, a riff on Sleeping Beauty'Äôs evil queen. Scott Rudin producing Cleopatra, based on the biography by Stacy Schiff. An adaptation of Patricia Cornwall's forensic detective Scarpetta. And Serena, a psychological suspense thriller from Darren Aronofsky about a woman bent on killing her husband'Äôs illegitimate son when she finds she can't bear a child of her own. Which of these eponymous roles sounds most promising to you? 25 READ MORE
Swiss authorities reject Polanski's extradition on Mon, Jul 12, 2010 | By Ryan Adams Dave Itzkoff at The New York Times has the best and briefest explanation of the Swiss decision: The justice ministry of Switzerland said on Monday that it had denied a request to extradite the director Roman Polanski to the United States, where he has been a fugitive since 1978 after pleading guilty to having sex with a 13-year-old girl, and that he was no longer under house arrest. In rejecting the extradition request from the United States, the Swiss ministry cited two factors: first, the Swiss said, the U.S. had failed to provide the records of a January hearing in Los Angeles County Superior Court that would have shown the judge in charge of the Polanski case in 1977 agreed that 'Äúthe 42 days of detention spent by Roman Polanski in the psychiatric unit of a Californian prison represented the whole term of imprisonment he was condemned to.'Äù Second, the Swiss said, when Mr. Polanski traveled in September 2009 to the Zurich Film Festival where he was arrested as he arrived at the airport, he did so in 'Äúgood faith'Äù that 'Äúthe journey would not entail any legal disadvantages for him.'Äù The Swiss justice ministry noted that Mr. Polanski had been staying regularly in Switzerland since 2006, and though 'Äúhe was registered in the Swiss registry of wanted persons, he was never controlled by the Swiss authorities.'Äù Do you think it's possible to discuss this legal conclusion in terms of how might affect the perception of Polanski and his future film prospects by the Hollywood community without clawing each other's eyes out? Do you think we can try, please? 22 READ MORE


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Teaching Note | HBS Case Collection | January 2010
by Arthur I Segel, John Vogel and Justin Seth Ginsburgh
Teaching Note for [209031], [209032], [209034], [209036], [209037], [209038], and [209039].
Keywords: Real Estate Industry; Raleigh; Las Vegas;
Segel, Arthur I., John Vogel, and Justin Seth Ginsburgh. "Real Property Negotiation Game (TN)." Harvard Business School Teaching Note 210-048, January 2010.
View Profile »View Publications »
Case | HBS Case Collection | June 2012 (Revised November 2013)
The Paris Opera Hotel
Arthur I Segel and Chad M. Carr
Keywords: real estate; international business; capital investments; Investment; Property; Business or Company Management; Real Estate Industry; Paris;
Teaching Note | HBS Case Collection | November 2013
8 Spruce Street
Arthur I Segel
Keywords: real estate; Investment; Real Estate Industry; Japan;
Porto Adriatico
Keywords: real estate; finance; developing markets;


text:
National Broadcasting CompanyVisit the official website
No Description
No Description
Captain Nice
Carter Nash was a chemist in a police department who discovered a liquid which could turn him into Captain Nice, an odd sort of superhero: very shy and dominated by his mother. Captain Nice flew (he feared heights) in his tattered leotards, fighting badguys because his mother told him to do so.Captains and the Kings
No DescriptionCar 54, Where Are You?
This black and white comedy show of the 1960's featured an unforgettable pair of hilarious police officers. Their scraps are many, but you can't help forgiving them their errors when their hearts are so big. Together, they fight crime in New York City, bringing out the best in others around them. Theme Song There's a hold-up in the Bronx, Brooklyn's broken out in fights. There's a traffic jam in Harlem, That's backed up to Jackson Heights. There's a scout troop short a child, Khrushchev's due at Idlewild... Car 54 where are you? Is this show on DVD? No. Do they re-run this show on TV? No, sorry, it isn't re-running on any channel. But, TV Land or the Hallmark Channel could re-run it, so check your local listings. But I don't guarantee this so don't take my word for it. Where have ...Caroline in the City
A situation comedy centered on Caroline Duffy, a young cartoonist living in the Tribeca neighborhood of New York City. Each episode begins with a brief animated sequence reflecting the autobiographical nature of her syndicated newspaper cartoon strip Caroline in the City, explicitly compared with the real comic strip Cathy in several episodes.Casper & the Angels
Welcome to the Casper & The Angels guide at TV Tome. There is no editor for this show. If you would like to be the editor look here for details. After 16 years since his last network show, Casper returns to NBC. The series is set in 2179 where Casper helps out policewomen Mini & Maxi on baffling cases (2 episodes per show). Hairy Scary was there to convince Casper to scare people! Casper & Hairy Scary had two NBC specials as well. A Halloween special where Hairy Scary & his friends ruin Halloween for Casper & his new orphan friends. And a Christmas special that featured Yogi & the gang taking shelter @ their haunted house.Celebrity Circus (US)
This NBC reality project sees celebrities running off to join the circus with avant garde professional troupes.Chase
Captain Chase Reddick is the leader of an undercover investigative unit of the Los Angeles Police Department that uses unorthodox methods in solving crimes. Reddick's men are specialists: MacCray trains police dogs, Sing is an expert motorcycle rider, Hamilton flies choppers and Baker is an expert behind the wheel of a car. Chase's unit answers only to the top brass in the department.Chase (2010)
"Chase" is a fast-paced drama from Emmy Award-winning executive producer Jerry Bruckheimer ("CSI" franchise, "The Amazing Race," "Pirates of the Caribbean" films) and executive producer Jennifer Johnson ("Cold Case") that drops viewers smack into the middle of a game of cat-and-mouse as a team of U.S. marshals hunts down America's most dangerous fugitives. Kelli Giddish ("Past Life") stars as U.S. Marshal Annie Frost, a cowboy boot-wearing deputy whose sharp mind and unique Texas upbringing help her track down the violent criminals on the run. Cole Hauser ("K-Ville"), Amaury Nolasco ("Prison Break"), Rose Rollins ("The L Word") and Jesse Metcalfe ("Desperate Housewives") also star as members of Frost's elite team.Cheers
Sam (Ted Danson), a former pitcher for the Boston Redsox, owns and runs Cheers, a cozy bar in Boston. Somewhat snobby, beautiful and intelligent Diane (Shelley Long) -- forced to become a waitress when her fiance jilts her -- constantly bickers with Sam. Eventually, they fall in love. Several wacky characters make the bar their home-away-from-home, including sarcastic waitress Carla (Rhea Perlman), beer-loving Norm (George Wendt) and Boston letter carrier Cliff (John Ratzenberger). A few seasons later, Sam sells the bar to buy a boat and sail around the world. But his boat sinks and he returns to bartending. Rebecca (Kirstie Alley), the new (more ambitious) manager, hires him back. They love to hate each other and eventually get together as well.Chicago Fire
No job is more stressful, dangerous or exhilarating than those of the Firefighters, Rescue Squad and Paramedics of Chicago Firehouse 51. These are the courageous men and women who forge headfirst into danger when everyone else is running the other way. But the enormous responsibilities of the job also take a personal toll.TV Reviews
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Thread: I still have naughty points?`
Monday, 12th November, 2012, 08:08 AM #1
I still have naughty points?`
I noticed that my infraction for a naughty word is still listed and up in my profile:
LPJ Designs Secret...
Reason: Inappropriate Language
2nd April 2011 08:04 AM by Umbran 1 / 27th January 2012 08:04 AM
However it should have gone at the start of this year. Anyreason why it is still live?
CheersGloria Finis
- EN World
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Friday, 16th November, 2012, 04:39 PM #2
Grandmaster of Flowers (Lvl 18)
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ø Ignore Plane Sailingwe'll look into it - they should expire after 300 days. Maybe @darjr could swing on by with an opinion.
Plane Sailing
(Enworld Admin)
If you need to email me click here
I'd like things to go back and forth from "ARGH!" to "WOOO!" more frequently. - Kamikaze Midget
Friday, 16th November, 2012, 05:32 PM #3
A 1e title so awesome it's not in the book (Lvl 21)
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ø Ignore MorrusThat's a confusion about the word "expire" (possibly a bad choice of word).
The board software has a setting whereby people get banned when they accumulate X points. We do not use that function; however we do still assign infractons as a convenient record for us mods, and each infraction has to have points associated even if we don't use them..
By "expire" it doesn't mean "all record of them being expunged like it never happened" it means "no longer counts towards the auto-banning accumulated total". And in our case, that means nothing anyway, because we don't have the feature turned on.
But the record is still there as a useful tool for the mods.
Friday, 16th November, 2012, 06:11 PM #4
Myrmidon (Lvl 10)
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ø Ignore SkidAceAhhh, so it's like our permanent school record......hehe...
"If you die first, we're splitting up your gear" - SkidAce
"Just because you don't like it, don't understand it, and can't explain it, doesn't mean that it doesn't work. "- Celebrim
"D&D is amazingly flexible, so there is no one well-accepted set of expectations there, and I've seen no evidence that there ever were." - Umbran
Friday, 16th November, 2012, 06:34 PM #5
Thanks for the answer.
Last edited by mach1.9pants; Friday, 16th November, 2012 at 06:41 PM.
Gloria Finis
Sunday, 18th November, 2012, 04:46 AM #6
Grandmaster of Flowers (Lvl 18)
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ø Ignore Scott DeWarWhere is this information? I want to make sure I have done no wrong, and if apologize as needed.
Check out Living Pathfinder!768392102109115 members and counting!!
Monday, 19th November, 2012, 09:59 AM #7
Ogremoch, Elemental Prince of Evil (Lvl 23)
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- May 2004
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ø Ignore DannyalcatrazI have naughty points, too...thank goodness!
Alas, they are not currently in use.
Actually, I can't even find my naughty points...perhaps that is my problem!Last edited by Dannyalcatraz; Monday, 19th November, 2012 at 10:04 AM.
IAAL...and an MBA. No, really!
Metal School Founder; Campaign Ideas; my 3.X Databases: The Monk, The Martial Arcanist, Aquatic Ideas, The Psychonomicon
Thursday, 22nd November, 2012, 10:07 PM #8
Waghalter (Lvl 7)
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- Dec 2009
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ø Ignore john112364Is this how Santa track the good little girls and boys? Too many naughty points and you get coal in your stocking!
(Though nowadays that may not be a bad thing lol.)
Saturday, 24th November, 2012, 05:50 AM #9
A 1e title so awesome it's not in the book (Lvl 21)
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- Apr 2005
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- Portland, Oregon, USA
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ø Ignore TarionzCousinAll the cool kids have naughty points... like me, of course.
Rose City Regulars - ENWorld Gamers in and around Portland, Oregon, USA
Fun D&D Photoshop Thread - Everyone is welcome to contribute.
Do You Want a New Avatar? - Free for an unlimited time.
Saturday, 24th November, 2012, 03:17 PM #10
Grandfather of Assassins (Lvl 19)
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- Feb 2003
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ø Ignore jonesy
My sarcasm detector is fusion powered. Yeah, that's powerful enough.
You are what you do.
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« Dombrowski On Avila, Pudge, V-Mart | Main | NL West Notes: Dodgers, Guzman, Giants, Hamels »
Mets Notes: Wright, Pagan, Herrera
Jon Niese faces Barry Zito tonight as the Mets open a four-game series with the Giants at Citi Field. Here's the latest from the Amazin's...
- David Wright tells reporters (including Jon Heyman of CBS Sports) that there have been "zero" discussions with the Mets about a contract extension. Wright doesn't mind, since he considers contract talk to be a distraction from playing. We heard last week that the Mets were keen to offer Wright a new deal but first wanted to ensure that he could stay healthy.
- "Whether he realizes it or not, Wright, who has said consistently he doesn't want to leave New York, is starting to put pressure on Mets ownership to get negotiations going to ensure that he does indeed stay," writes Bill Madden of the New York Daily News. Madden feels the Mets should do everything in their power to extend Wright, their franchise player.
- Angel Pagan talks to ESPN New York's Mike Mazzeo about being traded to the Giants in December, which Pagan said surprised him.
- Left-hander Danny Herrera will undergo Tommy John surgery to repair a torn ligament in his pitching elbow, Adam Rubin of ESPNNewYork.com reports.
MLBTR's Ben Nicholson-Smith contributed to this post
Marlins To Sign Rafael Furcal
White Sox To Sign Ronald Belisario
Dodgers Re-Sign Brian Wilson
Red Sox To Sign Edward Mujica
Royals Acquire Norichika Aoki
Yankees To Sign Kelly Johnson
Cubs Sign Wesley Wright
White Sox Re-Sign Paul Konerko
Rockies To Sign Justin Morneau
Yankees Agree To Sign Jacoby Ellsbury
Marlins To Sign Jarrod Saltalamacchia
Astros Acquire Dexter Fowler
Padres, A's Swap Seth Smith For Luke Gregerson
A's Acquire Craig Gentry, Josh Lindblom
Rays Extend Ryan Hanigan
Rays Acquire Ryan Hanigan
Tigers Sign Joe Nathan
Red Sox Sign A.J. Pierzynski
Athletics Acquire Jim Johnson For Jemile Weeks
Nationals Acquire Doug Fister From Tigers
Athletics Sign Scott Kazmir
Mariners Sign Willie Bloomquist
Blue Jays To Sign Dioner Navarro
Twins Sign Phil Hughes
Rays To Re-Sign Juan Carlos Oviedo
Giants Re-Sign Ryan Vogelsong
Twins Sign Ricky Nolasco
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Quick Hits: Red Sox, Coghlan, Beltran
Rangers Moving Toward Deal With J.P. Arencibia
West Notes: Cano, Angels, Rockies, Hudson
Minor Moves: Clay Rapada
Dodgers Re-Sign Brian Wilson
New York Notes: Granderson, Aoki, Choo
Marlins To Sign Rafael Furcal
Yankees Optimistic About Hiroki Kuroda's Return
White Sox To Sign Ronald Belisario
Mariners Could Offer Cano $225MM
NL Notes: Braves, Cubs, Phillies, Pirates, Mets
Central Notes: Aoki, Hughes, Dunn
Twins Sign Phil Hughes
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Peralta, PED Incentives, And The Next JDA
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8 hrs ago | The Motley Fool
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the Amazing Spider-Man 2 Official Plot Synopsis Implies Oscorp is Behind Everything
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It looks like you won't have to wait until Thursday, December 5th, to see the first footage from The Amazing Spider-Man 2 as Sony Pictures International has released three short special effects teasers for the upcoming trailer.


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Red flags, unexplained etchings on a shotgun, claims of poor police response. It's been three days since Aaron Alexis went on a shooting rampage at the Navy Yard in Washington. And each new day since has brought new revelations about his past, the attack and the subsequent inquiry.
Talk centered this week on how Alexis could maintain his security clearance and access to military contracting jobs despite a checkered history in the Navy and with civilian police.
Defense Secretary Chuck Hagel announced Wednesday that the Defense Department would stage a comprehensive review of security practices at military bases worldwide. And late Wednesday night, the Navy secretary said he had ordered three reviews of security clearances, including one into the granting of Alexis' clearance.
Here's a recap of the latest developments, meant to bring you up to speed quickly.
Valid identification: Alexis had just started a contracting job on the base, so he was able to gain access to Building 197 like any other worker. He walked in, a law enforcement source said, with a bag slung in over his shoulder, passing through security with other employees arriving for work. While red flags come to light after the shooting, Navy officials say none of the details would have been enough to deny him clearance.
Background check: Government contractor USIS said Thursday that it performed Alexis' 2007 background check for the Office of Personnel Management. USIS is the same firm that performed former National Security Agency contractor Edward Snowden's background check for OPM that granted him a security clearance. The firm is under investigation.
Disassembled shotgun: The bag Alexis was carrying apparently contained a disassembled Remington 870 shotgun, a law enforcement official said. Alexis is seen on surveillance video ducking into a bathroom and leaving with the shotgun.
30 minutes: Authorities believe Alexis came out of the bathroom and immediately began shooting at random, FBI Director James Comey said Thursday. Investigators believe he then went floor to floor shooting at workers, Comey said. Authorities and witnesses had previously said it appeared Alexis shot mostly from the building's atrium. According to law enforcement officials, he shot a guard on the first floor and took his handgun. It took more than 30 minutes for police to hunt down and kill Alexis, D.C. Metropolitan Police Department Chief Cathy Lanier said.
Unexplained etchings: Alexis etched phrases into the shotgun, a source said. But investigators don't know what to make of it. They read: "Better off this way" and "My elf weapon."
Stand down: A government official told CNN that when the first radio call came in about a shooting at the Navy Yard, highly trained tactical U.S. Capitol Police officers headed to the base but were told by a watch commander to stand down. The chief has now ordered an "independent fact review." D.C. Police Chief Lanier told CNN's Wolf Blitzer on Thursday that she was not aware of anyone being turned away. "I don't think you could have had a faster response," she said.
Undermanned: The Navy Yard also has its own police force. But there were only seven officers working Monday, a police officer and a union official said.
Blood everywhere: Navy officials say damage inside Building 197 is so extensive, it may take weeks to repair and reopen it. "There is blood everywhere," one official said. "There is damage everywhere."
Steady recovery: One of the three hospitalized shooting victims has been released. The woman was struck behind the ear. Two others -- a civilian and a police officer -- remain in fair condition. The officer, Scott Williams, is in "great spirits," said Chief Lanier. "I do think he's going to be OK, and recover fully, but he's still having some pretty serious complications," she said.
Still a mystery: Investigators have talked to Alexis' friends and family. They've pored over his computers and other possessions. But, say law enforcement sources, nothing points to a specific motive for the rampage. "I'll reserve judgment on that until all of the work of the FBI is done," Lanier told CNN's Blitzer. "There's still a lot more to do."


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Opening Tip: Bulls' roster isn't changing
Nick FriedellCHICAGO -- John Paxson, Tom Thibodeau and Gar Forman sat halfway up on center court at the United Center on Tuesday night dreaming like the rest of the scouts, coaches and personnel directors in attendance at the Champions Classic. The amount of t...
Blog | November 13, 2013 -
Derrick Rose scores 22 points in return to United Center
Derrick Rose scored 22 points in his long-awaited return to the United Center to lead the Chicago Bulls to a 96-81 preseason victory over the Detroit Pistons on Wednesday night.
Recap | Box Score | Conversation | October 16, 2013 -
Derrick Rose of Chicago Bulls focused on rehab amid whirlwind of ...
Jon GreenbergRose focuses on his rehab amid a whirlwind of speculation.
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Brandon Jennings scores 35, leads Bucks past division rival Bulls...
Brandon Jennings scored 20 of his 35 points in the third quarter and the Milwaukee Bucks beat the Chicago Bulls 104-96 on Wednesday night for their second consecutive victory under interim coach Jim Boylan.
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First Cup: Thursday
Henry AbbottJohn Canzano of The Oregonian: "The executives charged with conducting the latest round of job interviews at One Center Court believe there are a plenty of options available to the Trail Blazers when it comes to filling their vacant general manager p...
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Los Angeles Clippers coach Vinny Del Negro hopes the Chicago Bull...
Nick FriedellLos Angeles Clippers coach Vinny Del Negro is pulling for the Chicago Bulls players, but he said his relationship is broken with John Paxson and Gar Forman.
Story | Conversation | July 19, 2010 -
First Cup: Friday
Nick BorgesMarc Berman of the New York Post: A large portion of the pro-Knicks crowd at Barclays Center stood up and cheered as Andrea Bargnani walked off the court with 8:23 left after his first NBA ejection for jawing with trash-talk king Kevin Garnett. More ...
Blog | December 06, 2013 -
Mavs handling business at home
Tim MacMahonDALLAS - A pretty good way to get your tickets punched for the playoffs is to dominate on your home court. All indications are that the Dallas Mavericks are going to be awfully hard to beat at the American Airlines Center this season. It hasn't...
Blog | November 21, 2013 -
Noah brushes off fan's obscene gesture
Doug PadillaDEERFIELD, Ill. -- Chicago Bulls center Joakim Noah let it be known Thursday that he was none-too-thrilled with getting a middle finger thrust into his face as he walked off the court following an ejection during Wednesday's playoff defeat against th...
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2013 NBA Playoffs: Joakim Noah of Chicago Bulls brushes off obsce...
Doug PadillaChicago Bulls center Joakim Noah let it be known Thursday that he was none-too-thrilled with getting a middle finger thrust into his face as he walked off the court following an ejection during Wednesday's playoff defeat against the Miami Heat.
Story | Conversation | May 09, 2013 -
Hibbert: Pacers know Bulls still formidible
Scott PowersSOUTH BEND, Ind. -- Indiana Pacers center Roy Hibbert said Friday he and his teammates respect the Chicago Bulls with or without Derrick Rose on the court. "I think their other veteran players like (Carlos) Boozer, (Joakim) Noah, they're going to ...
Blog | October 26, 2012 -
Chicago Bulls guard Derrick Rose has surgery
Report: Derrick Rose has surgery to repair his torn ACL.
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New-look Curry solution to Heat old issue?
Michael WallaceMike Ehrmann/Getty Images After many trials on and off the court, Eddy Curry finally returned to the floor. MIAMI - Soaking wet and emotionally drained an hour after his long-awaited return to the relevance of an NBA game, Miami Heat center Eddy Cu...
Blog | January 20, 2012 -
Heat's defense was established on Day 1
Michael WallaceMike Ehrmann/Getty Images Dirk Nowitzki has been smothered by a Heat defense that was established back in September. DALLAS -- Even before the doors opened to the basketball courts at Aderholt Fitness Center on that military base that late Septem...
Blog | June 07, 2011 -
Nets-Bulls Preview
Nets-Bulls Preview
Preview | April 12, 2011 -
Chicago Bulls forward Carlos Boozer recounts details of renting h...
Nick FriedellWhen the Chicago Bulls take the court at Target Center in Minneapolis on Wednesday, it will be interesting to see if Timberwolves fan and music superstar Prince is in the crowd to watch his former landlord -- Carlos Boozer.
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Colombia >
Bolivar Department >
Cartagena District >
Free Breakfast
Free High-Speed Internet
Pets Allowed
Room Service
Ranked #3 of 94 B&Bs / Inns in Cartagena
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Hotel Class:2.5 star — Les Lezards Bed & Breakfast 2.5*
- Official Description (provided by the hotel):
- A beautiful and romantic colonial guesthouse in Cartagena de Indias, in the vibrant and traditional Getsemani area, one of the last truly exotic places in the Caribbean, the most dynamic downtown location where new boutique hotels, bars and restaurants sprawl. Positioned in a quiet street, away from traffic and commercial activities, and just a few feet away from the Arsenal and the booming Calle del Guerrero and Media Luna night spots and at walking distance from all the best restaurants and attractions. The house designed by award winning architect blends colonial with mediterranean style and is decorated with items and maps collected during worldwide journeys. All rooms are custom designed. The cotto floors with spanish ceramic accents help you cool down and unwind surrounded by an abundant tropical vegetation with adult mango and palm trees. Guests can relax in the patios and enjoy an open air tile jacuzzi on the terrace and a mirador/solarium with views on the Cathedral, the churches of San Pedro and La Trinidad and the Castillo San Felipe. The house is on a north-south axis and enjoys plenty of natural ventilation ... more less
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The List: Top South Florida Commercial Real Estate Developers
- Gilberto Medina
- Research Director- South Florida Business Journal
- Email | Twitter
A West Palm Beach-based company ranked first on the South Florida Business Journal's list of the top commercial real estate developers.
The company earned the top spot based on its 1.76 million South Florida new rentable square footage in 2011.
To see who topped the list, click through the photo gallery included with this post.
Newcomers to the list include Courtelis Co., McCraney Property Co. and The Kolter Group LLC.
The complete commercial real estate developers list includes contact information and comparisons to the previous year. It is available online and in print for subscribers only. Click here for subscription information.
We are currently surveying for the following 2012 lists: convention & meeting sites, hotels, architecture firms, fastest-growing technology companies, corporate philanthropy, MBA programs, private schools and colleges & universities.
Gilberto Medina is research director for the South Florida Business Journal.
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I was impressed by B2B International's outstanding abilty to execute on a compressed timeline as well as their abilty to analyze and communicate extensive data in a concise and meaningful way.
According to new research by Experian, Manchester is now rated as the most 'vibrant' city centre in Britain. The "Vibrancy Index", compiled using census and commercial data, highlights the strong influx of young professionals and students to the city in recent years. Manchester, rated 21st only a decade ago, has seen its young
BIG, the Business Intelligence Group, in conjunction with the ICG, is hosting its second Northern forum of 2013 in Manchester on 5th June. The event, entitled 'Look underneath your nose', is all about using a little bit of imagination and insider know-how to get a head start on your research requirements.
In this week's Business Surgery, Julia Cupman highlights that customers in loyalty programs are not necessarily loyal. Although it is relatively easy to reward the advocates of a brand, the big challenge comes with addressing the detractors, especially before they can cause damage.
On a flight to Chicago last week, a colleague
Business-to-business market research and business intelligence agency, B2B International, was voted one of the top six research agencies in the country in the 'Best Agency with a turnover of under £20m' category at the Market Research Agency (MRS) Awards.
At the MRS awards evening in London on 10th December, B2B International was judged
B2B International, which has chosen Manchester's The Christie as its nominated charity of the year, has beaten its annual fundraising target of £1,000 in less than six months.
The business-to-business market research specialist – which also has an office in London as well as in locations across mainland Europe, North America and Asia
B2B International is delighted to be the official shirt sponsor of the USA national polocrosse team, which is competing in the World Cup in July in England. The tournament will be held at the Onley Grounds Equestrian Centre in Rubgy, Warwickshire, UK.
The global research and market intelligence company has an active interest
In this week's Thursday Night Insight, Peter Mullarkey tells us how going out for an impromptu meal leads to a smorgasbord of options, washed down with plenty of discussion.
On a recent trip to Liverpool to visit an old school friend. My Girlfriend and I stayed in a hotel close to the shopping and
Always on the lookout for interesting articles about b2b marketing, we recently came across CeeKue.com, which contains some interesting blog posts.
And a great piece to start off the year is, of course, one that considers how B2B marketing will develop and change over the course of 2011, and how these changes should impact
No one would question the importance of keeping customers satisfied. In the latest white paper from B2B International, they show how to address the subject of customer satisfaction and loyalty and investigate what customer satisfaction means as well as actioning a four-point plan for making improvements from customer satisfaction data.
The white
Paul Hague confesses to being a slow learner when it comes to taking sage advice from this mother
Our mothers are great sources of wisdom and we can all remember bits of advice they peppered us with inour formative years. I think I was half asleep or deaf throughout most of my childhood but
I was impressed by B2B International's outstanding abilty to execute on a compressed timeline as well as their abilty to analyze and communicate extensive data in a concise and meaningful way.
Throughout we felt assured that you did understand our brief/needs and that the recommended methodology would achieve the desired result.


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Solid results for same-store sales
By Staff -- Home Textiles Today, 3/9/2004 12:00:00 AM
NEW YORK — Maintaining their recent upward momentum, same-store retail sales jumped up 5.1 percent during the first week of March, once again beating expectations for both mass merchants and department stores, The Redbook Average reported.
Sales at department stores continued to rebound from last year's depressed levels, rising by 3.7 percent and beating a planned 3.6 percent increase. Mass merchants as well exceeded expectations, pushing sales up by 6 percent, ahead of a planned 5.8 percent.
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The WEBstaurant Store carries a selection of Cream Whippers in 1/2 liter and liter capacities. Also find N2O replacement chargers to use with your cream whipper bottles.
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- Fruit / Vegetable Slicers, Cutters, and Dicers Replacement Parts and Accessories
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10 Things That Really Could Have Been Easier
by Break.com Staff on Apr. 02, 2013
Most things can be done an easy way or a hard way. These people opted for the hard way.
1. Trim the hedges
2. Haulin'
3. Finally, an easy way to listen to music
4. USB? What?
5. Not an expert at revenge
6. Not a tow truck
7. Why put it in the back?
8. Warm water on the way!
9. Show off
10. Workin' Out


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"Oakland is a Top 10 Green Cities" Oakland Favorite Tip by supune
Oakland Favorites: 15 reviews and 15 photos
Favorite thing: SustainLane.com has called Oakland a frontrunner for having good green and sustainable waste and energy policies.
Here's what they say:
"Residents of the ethnically diverse port city of Oakland enjoy sunny days, clean air (thanks to Pacific breezes), locally-produced food, and public transportation ridership of over 20 percent. Since Mayor Ron Dellums took office in January of 2007, the city has also adopted a "Zero Waste by 2020" plan, launched an "Oil Independence Oakland by 2020" task force, and banned plastic bags and styrofoam takeout containers. Oakland has one of the highest solid waste diversion rates in the country and an energy matrix that's more than ten percent renewable. The city has partnered with the University of California Berkeley to study how to source 30 percent of its food locally, and it's part of an alliance with San Francisco, Berkeley, and other Bay Area communities to jointly get half of their energy from renewable sources by 2017. Two areas that still need work? Congestion and housing affordability. Finally, much like Detroit, Memphis or Baltimore, once Oakland gets its crime rate under control, it could be as desirable a place to live as its cross-bay neighbor, San Francisco." -- http://www.sustainlane.com/us-city-rankings/cities/oakland
In addition there are lots of green local businesses as well as diverse groups of people that consider the environment as they go about their daily tasks. I was surprised to see Oakland being considered at the top, but then after considering how people that live and work there think, I'm not really surprised. There's still a lot of neighborhoods that need to clean up. But, it looks like Oaktown is off to a great start. San Francisco (#2 on the list) and the rest of the Bay Area do a great job of keeping the environment in mind, so it's good to see the 2 main cities in the top 10 out of the most populous cities in the United States.
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I tend to keep people at bay until I get to know them. Trust is not owed, it is earned. I am slightly detached, sometimes sarcastic, often cynical, and always loyal. Once someone is in my circle of friends, they are there for life. It's all or nothing with me. I have somehow fallen into the role of being "Dr. Phil" for my group of friends. I am brutally honest, if you ask me a question I am going to give you the answer, minus the sugar coating that most people would give you. I call people on their bullshit and I expect them to call me on mine. I love to have fun and try new things. I am what I am, love it or leave it.
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Charming Cabin on Taneycomo Lake
You sent a message to this manager.
- Minimum stay:Contact manager
- Internet:No
- Pets considered:Ask Manager
- Wheel chair accessible:No
Branson cabin description
All you need to bring is food, clothes, and toiletries!
Call Us
No sales talks to endure! Very peaceful!
This is not a timeshare or a condo.
This is my own private lake cabin.
Why so cheap???
I just started renting this summer.
I'm simply trying to get a lot of business - trying to get the word out!!!
Hoping you will not only come and stay but will tell your friends!
Comes with:
free Dish Top 200 and all the premium channels (HBO, SHOWTIME, CINEMAX, STARS)
central heat/air
Aspen log furniture/beds King bed, Queen bed, and Aspen sofa sleeper
free high speed WiFi internet free use of computer/printer
outdoor gas grill
linen essentials (all bedding, towels, washcloths)
cooking essentials (pots, pans, cutlery, utensils, coffee maker, toaster, microwave)
At least 2 nights booking required.
Cost is for up to 4 people. Add an additional $10 per person/per night for more than 4 people.
2 Bedroom/1 Bath $100 per night - or stay 5 nights and get the 6th free
No pets inside.
No smoking inside.
Deposit/Cancelation policy:
50% deposit is required to make your reservation.
If you cancel within 14 days of arrival you will lose the deposit unless I can fill your reservation.
The remaining 50% will be collected upon arrival.
You can pay with cash,check,or credit card.
Property Type
- Cabin
Accommodation Type
- Vacation Rental
Bedrooms: 2 Bedrooms, Sleeps 6, Beds for 6
- Linens Provided
- Washing Machine
- Clothes Dryer
- Parking Off Street
- Parking For RV/Boat/Trailer
- Air Conditioning
- Satellite / Cable:
- Television:
- DVD Player
- CD Player
- Stereo
Location & View
- Lakefront
Other Activities
- Come To Branson. Stay On The Lake.
Write a review-
Branson close, Lake closer
Branson close, Lake closer
- Guest Julie (Broken Arrow, OK)
- Date of stay 09/05/13
- Review Submitted 09/08/13
Two couples for three nights and this was the perfect spot. Close enough to Branson for girls' shopping, close to the water for guys' fishing. The cabin is properly describe in the ad. Truly only need food, clothing and personal items. Kitchen is fully equiped but if you oppose hand washing dishes, take disposables as there is no dishwasher. We found the WiFi and satellite TV to be great bonuses. There is a private boat ramp and dock within walking distance. The meadow separates the cabin from the water where we saw deer each morning. The drive into Branson is not too far to have the benefit of such a peaceful place to stay. It was easy to find using our GPS. I suggest grocery shopping before you leave Branson as the local grocery store is quite pricey. There is a Dollar General Store close which has a decent grocery section. Owner is very polite and welcoming. We'll be planning another trip soon! OwnerRecommended for: Romantic getaway.
Did you find this review helpful? Yes | No Helpful votes: 2/2
june 2013 renters
june 2013 renters
- Guest boo (florissant,mo/midwest)
- Date of stay 06/14/13
- Review Submitted 07/07/13
rented the cabin for 2 nights and had 6 people. It is immaculately kept and stocked and has charm and privacy of the country and still very accessible to Branson. If your looking to a peaceful weekend this is the rental for you. We were extremely pleased and the cabin met all expectations and then some. The lake is about 100 yards away, there is a canoe for use, fishing poles, screened in porch, campfire setup as well as a view of the bluffs across the lake. All the amenities of home even a washer and dryer. If you are looking for a great getaway at a great price check out this cabin. Owner is also extremely friendly and accomadateing.Recommended for: Romantic getaway, sightseeing, age 55+, families with young children, people with disabilities, families with teenagers.
Did you find this review helpful? Yes | No Helpful votes: 4/4
Currency Conversion$100 PER NIGHT (2 NIGHT MINIMUM - NO CLEANING FEES!)
Note: Until confirmed, rates are subject to change without notice.
This manager accepts: Credit cards.
Always make sure to call the number on the listing to confirm payment details. Only pay using credit card, PayPal, check or direct bank transfer. NEVER pay by cash or instant money transfer services such as Western Union or MoneyGram. Learn more
Don't forget your vacation protection! Get protected now
Adding our Vacation Protection services can make sure your getaway goes smoothly, no matter what. We offer Cancellation Protection, Carefree Rental Guarantee, and Damage Protection so you can truly relax.
Sorry this information is not available. Please contact the manager for more information.
Manager info
Year Purchased: 2012
About: My name is Gregg Mathis. I am a 4th grade teacher at Forsyth, MO. I started renting the cabin in the summer of 2012. Hope you get to come to Branson and stay at my cabin!!
Contact us
- Primary: 417-546-1401 best to call after 3pm on weekdays.
- Click Here to see All My Rental Listings
There have been visitors to this page since the counter was last reset in .
This listing was first published here in 2012.
Date last modified - Tuesday, September 24, 2013
Always make sure to call the number on the listing to confirm payment details. Only pay using credit card, PayPal, check, or direct bank transfer. Learn More
Three services to protect your trip:
Protect your payments in case you need to cancel.
Guarantee the rental meets your expectations.
Ensure you're prepared in case of accidental damage.


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A collection of news and information related to FedEx Corporation published by this site and its partners.
Top FedEx Corporation Articles
Displaying items 78-88
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