text:
Industry, Environmentalists Agree on Tough Standards
20 March 2013
By The Associated Press
PITTSBURGH -- Some of the nation's biggest oil and gas companies have made peace with environmentalists, agreeing to a voluntary set of tough standards for fracking in the Northeast that could lead to a major expansion of drilling.
The program announced Wednesday will work a lot like Underwriters Laboratories, which puts its familiar UL seal of approval on electrical appliances that meet its standards.
In this case, drilling and pipeline companies will be encouraged to submit to an independent review of their operations. If they are found to be abiding by a list of stringent measures to protect the air and water from pollution, they will receive the blessing of the new Pittsburgh-based Center for Sustainable Shale Development, created by environmentalists and the energy industry.
Many of the new standards appear to be stricter than state and federal regulations.
If the project wins wide acceptance, it could ease or avert some of the ferocious battles over fracking that have been waged in statehouses and city halls. It also could hasten the expansion of fracking by making drilling more acceptable to states and communities that feared the environmental consequences.
Shell Oil Vice President Paul Goodfellow said this is the first time the company and environmental groups have reached agreement to create an entire system for reducing the effects of shale drilling.
"This is a bit of a unique coming-together of a variety of different interests," said Bruce Niemeyer, president of Chevron Appalachia.
In agreeing to the self-policing system, members of the industry said they realized they needed to do more to reassure the public about the safety of fracking. On the other side, environmentalists said they came to the conclusion that the hundreds of billions of dollars in oil and gas underground is going to be extracted one way or another and that working with the industry is the quickest path to making the process safer.
"We do recognize that this resource is going to be developed," said Robert Vagt, president of the Heinz Endowments, a charitable foundation that has bankrolled anti-fracking efforts. "We think that it can be done in a way that does not do violence to the environment."
In addition to Shell and Chevron, the participants include the Environmental Defense Fund, the Clean Air Task Force, EQT Corp., Consol Energy and the Pennsylvania Environmental Council. The organizers hope to recruit others.
The new standards include: limits on emissions of methane, a potent greenhouse gas, and the flaring, or burning off, of unwanted gas; reductions in engine emissions; groundwater monitoring and protection; improved well designs; stricter wastewater disposal; the use of less-toxic fracking fluids; and seismic monitoring before drilling begins.
For example, the plan requires companies to recycle 90 percent of their wastewater and to check water supplies around a well for pollution for a year after drilling is completed.
The project will cover Pennsylvania, West Virginia and Ohio -- where a frenzy of drilling is underway in the huge, gas-rich Marcellus and Utica shale formations -- as well as New York and other states in the East that have put a hold on new drilling.
The cooperation between the two longtime adversaries might be part of a trend.
Earlier this month, industry and environmental groups in Illinois announced that they worked together on drilling legislation now pending there. The Pittsburgh project, though, which has been in the works for nearly two years, would be voluntary -- and would bypass the often turbulent legislative process altogether.
"We believe it does send a signal to the federal government and other states," said Armand Cohen, director of the Boston-based Clean Air Task Force. "There's no reason why anyone should be operating at standards less than these."
Shell said it hopes to be one of the first companies to volunteer to have its operations in Appalachia go through the independent review. Chevron said it expects to apply for certification, too, when the process is ready to start later this year.
Mark Brownstein, an associate vice president with the Environmental Defense Fund, said many oil and gas companies claim to be leaders in protecting the environment, and that "this can be one opportunity for them to demonstrate that leadership," by submitting to an audit.
During fracking, large volumes of water, along with sand and hazardous chemicals, are injected into the ground to break rock apart and free the oil and gas. In some places, the practice has been blamed for air pollution and gas leaks that have ruined well water.
The Pittsburgh project will be overseen by a 12-member board consisting of four seats for environmentalists, four for industry and four for independent figures, including former Treasury Secretary Paul O'Neill and Christine Todd Whitman, the former New Jersey governor and Environmental Protection Agency chief.
The center's proposed 2013 budget is $800,000, with the two sides expected to contribute equal amounts, said Andrew Place, the project's interim leader and director of energy and environmental policy at EQT, an Appalachian energy company.
Mark Frankel, an expert on ethics and law at the American Association for the Advancement of Science in Washington, said the idea sounds promising, but that it remains to be seen if the new standards are a significant improvement over existing laws. He said there also are ethical and policy questions.
"What does it mean to have an independent board?" he asked. "Who's on it? How do they get on it?"
George Jugovic, president of the environmental group PennFuture, one of the participants, said the industry's involvement makes this different from past debates over fracking.
"Buy-in from them is huge. That provides leadership from within," Jugovic said. "It's very different from someone from the outside saying, 'You can do better.'"
Some critics of fracking, however, aren't swayed by the new plan.
"Fracking is an inherently dangerous industrial process that takes us away from sustainable energy solutions," said Kathy Nolan of Catskill Mountainkeeper, which is fighting fracking in New York state. "Its costs to humans and our environment just aren't worth it."


text:
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subset: commoncrawl


text:
A Kidde Smoke Alarm is a good choice if you are looking for a smoke alarm. But how do you choose between the different models? Here are a few important tips for purchasing a smoke and carbon monoxide detector. Read on to learn more about Kidde. Don't forget to check out our Kidde product reviews. We hope this article has been helpful. And don't hesitate to ask us about your experiences with Kidde!
The Kidde Smoke Alarm is a trusted brand that offers quality and safety. The i12040 Hardwire Smoke Alarm with Battery Backup features interconnectivity with 24 devices and easy installation. The alarm's large mounting base with plastic cover makes it easy to mount and comes with a 9V Battery. This is the ideal smoke alarm for high ceilings and hallways. The alarm is easy to replace batteries and is UL Listed, so you'll be protected from fire.
The latest generation of smoke alarms uses TruSense technology. This technology allows it to distinguish between fast-flaming fires and slow-burning fires. The Kidde 2070-VDSR's date code and install date help consumers easily identify the correct replacement. The Kidde 2070-VDSR's dual sensor design and date-coded label provide additional assurance. Consumers should avoid using the alarm that has the yellow cap, as this will compromise the smoke alarm's detection.
Kidde Smoke Alarm
The Kidde i9010 sealed, battery-operated smoke alarm has a self-activating mechanism and a Hush(tm). The alarm's battery never needs replacement and has no pull tabs for installation. The alarm has a battery that can last for up to 10 years, saving consumers money on labor and batteries. The smoke alarm can be used in any room of the home for up to one year before the battery needs to be replaced.
The Kidde i4618 is AC/DC powered and features ionization sensing technology to detect invisible fire particles. This technology is more effective in detecting fire particles than traditional photoelectric alarms. You can choose between a photoelectric or ionization smoke alarm, depending on your needs. Kidde smoke alarms are also interconnected, so you can choose which devices you want to link to your system. The Kidde i4618 Hardwire Smoke Alarm With Battery Backup is a great choice for homes with multiple smoke detectors.
You should immediately delete any files that you have accidentally put into your Kidde smoke alarm. You could endanger your device by storing the files. If your smoke alarm continues to beep, check the batteries every seven to ten years. The processor will hold false conditions and should readjust itself when the battery is reinserted. If it does not, you will need to reset the alarm by unplugging. This is an easy process.
Kidde Carbon Monoxide Alarm
The Kidde Carbon Monoxide Alarm warns you if there is high levels of carbon monoxide in your home. You can use it alone or in conjunction with an interconnected alarm system to get more warning and time to flee. This alarm comes with a 9V battery backup to ensure that it keeps working even in the case of a power failure. It is a great tool to protect your home. This product is a trusted name in fire safety.
A Kidde Carbon Monoxide Alarm is highly effective at detecting dangerous gases and fire calamities. These alarms are designed to detect these dangers without the need for a smell. They can even give you voice alerts, so that your family and friends will be notified if a fire breaks out. You can learn more about this alarm by visiting the Kidde website. You can rest assured that your family will be safe for 10 years after you purchase a Kidde Carbon Monoxide Alarm.
Kidde Smoke And Carbon Monoxide Alarm
The Kidde Smoke and Carbon Monoxide Alarm, a smart safety device, sounds an alarm when there is a fire and warns users when the battery is low. The alarm is powered by a sealed lithium battery and features both electrochemical and photoelectric sensing capabilities. A voice warning system alerts users when there is a potential for CO or fire and the sensitivity level of the unit is adjustable for maximum protection.
Every home that has appliances that produce carbon monoxide is at risk of elevated levels. The first line of defense against a fire is the Kidde Smoke and Carbon Monoxide Alarm. In the United States alone, home fires occur thousands of times a year. When they do occur, people often have limited time to evacuate. An alarm can help people quickly evacuate their home and avoid any potential health hazards.
Kidde Detectors
There has been widespread concern about the recent recall of Kidde smoke alarms. The TruSense smoke alarm as well as the combination smoke-carbon monoxide alarm are among the products being recalled. The manufacturer has issued a statement to customers via social media and urged them to check the CPSC bulletin. Although no incidents were reported, the company believes that this recall was necessary due to an overabundance of caution. Read below for more information about the recall.
The most popular Kidde smoke alarm is the 1276, which uses an AC/DC power source and a 9V battery backup. This alarm uses ionization sensor technology to detect small particles of fire that are too small to be seen by the human eye. The Kidde smoke alarms have a 10-year limited warranty and are UL-listed. Kidde is a world leader in fire safety equipment, and this product is a great choice.
Kidde Carbon Monoxide Detector
If you're in the market for a carbon monoxide smoke alarm, look no further than a Kidde product. Made by a renowned company that has been in business for over a century, Kidde alarms provide quality protection for your home. Some models can be powered by batteries, while others have AC-wired models that provide voice warnings. A recall is in effect for 226,000 Kidde smoke and carbon monoxide alarms that were sold between May 2019 and September 2020.
The Kidde COSM-BA is a combination smoke and carbon monoxide alarm that offers two essential safety devices in a single device. Kidde alarms feature a voice warning system that alerts you of smoke or fire, and adjusts its sensitivity to accommodate different levels of smoke and CO in the air. It also has a programmable low battery indicator and a voice warning system that will alert you if the battery is low.
When activated, Kidde smoke and carbon monoxide alarms will produce a beeping or chirping sound. This is normal and prevents the device from malfunctioning. The alarm will stop ringing again unless a new battery is installed. If it does, you should unplug the device and reset the circuit. Contact the manufacturer's customer support if you are unsure if it is working.
Kidde Smoke Detector
If you're looking for a smoke alarm, look no further than a Kidde. This manufacturer is a leader when it comes to smoke alarms. You can choose from a variety of models, from simple smoke alarms to advanced alarms that can detect carbon monoxide. A Kidde Smoke Alarm will be available in a local store. There may also be a few others in your area. This review will discuss the differences between a Kidde and a traditional smoke alarm.
The Kidde Smoke Alarm includes a mounting bracket that attaches to it. Simply remove the bracket by moving it counterclockwise. Next, insert the smoke alarm in the mounting bracket. If it's already installed, you can push the "silence" button to silence the alarm. If the alarm sounds, you need to push the "Push Test Button" button to conduct a quick diagnostic test. The device will flash red and sound the alarm if it detects smoke.
Kidde Combo Smoke Co Alarm
There is a good chance that you have heard of the recall of Kidde Combo Smoke Co Alarms. This recalled product is a combination smoke and CO alarm with a 10 year battery and sealable 10 year battery. These alarms should be used until the new ones are installed, and if the recall hasn't affected you yet, you can keep using your old alarm while waiting for the replacement.
The Kidde KN-COSM-BA Carbon Monoxide and Smoke Co Alarm combines two important safety devices in one unit. It has a voice warning system that alerts you when there is a fire and a low battery alarm. The device can also announce when a battery is due for replacement. For added safety, a 3.7 V AC backup battery is included.


text:
NY dad forgets baby in car for 8 hours on cold day
Staff Writer
Fosters Daily Democrat
COLONIE, N.Y. (AP) — Authorities say a New York man who left his 1-year-old son in his car for eight hours in frigid weather only realized his mistake after a call from his wife.
Police in the Albany suburb of Colonie say the man forgot to drop off his son at day care and left the child strapped in the back seat of the car when he parked outside his office Thursday morning.
Officials say the man received a call from his wife at about 4 p.m. inquiring about their child. He called for an ambulance and the boy was checked out at a hospital and released. Police say the baby didn't suffer any injuries despite temperatures that didn't top 15 degrees.
Police said Friday they haven't determined if the father would be charged.


text:
Today in the News: Homeland Security warns against using Internet Explorer
News to know
Microsoft says a security gap in Internet Explorer could allow an attacker to take complete control of a computer if the user clicks on a malicious link. The vulnerability affects versions 6 through 11 of the Web browser. Microsoft Corp. said Saturday that it was aware of "limited, targeted attacks" that tried to exploit the security gap. The company is working on a fix which it plans to provide in a software update on May 13. In the meantime, Microsoft encourages customers to enable a firewall, apply all software updates and install anti-malware software. A division of the Homeland Security Department recommends that users download a security toolkit from Microsoft or use another browser until an update becomes available. - AP
Quote of note
"Edie and I are fine. We're going to see our son's baseball game this afternoon." - Paul Simon, talking today outside the Norwalk, Connecticut, courthouse where he and his wife appeared before a judge on disorderly conduct charges. The two were arrested Saturday night after what Simon called an argument, and they appeared congenial when seen together today.
Hot video
The science behind the super tornado outbreak.
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text:
Wind power
New monument protection law in Lower Saxony having an effect in court
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Your search for "Interviews." (as subject) and "Venezuelan Labor Leaders oral history collection."(as project) and "Oral histories."(as subject) and "Labor unions--Venezuela--History--20th century."(as subject) and "Tremont, Arturo--Interviews."(as subject) and "Labor movement--Venezuela--History--20th century."(as subject) and "Interviews."(as subject) returned 2 hits
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Oral history interview with Arturo Tremont, 1989. [CCOH]
Oral history interview with Arturo Tremont [electronic resource], 1989. [CCOH]
Refine your results
Venezuelan Labor Leaders oral history collection. (2)
Ellner, Steve, interviewer. (2)
Tremont, Arturo--Interviews. (2)
Ellner, Steve, interviewer. (2)
Interviews. (2)
Labor movement--Venezuela--History--20th century. (2)
Labor unions--Venezuela--History--20th century. (2)
Oral histories. (2)
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Praying for:
Baloch Lashkrani of Pakistan
Topic: 1 of 3
Regional: Culturally sensitive TV and radio
Reaching the unreached is a monumental task. There just aren't enough individuals to get the word out to everyone. TV and radio can be incredibly powerful mediums for communicating the gospel, because they can penetrate areas where Christian workers may not be able to go.
Rom. 15:20 It has always been my ambition to preach the gospel where Christ was not known, so that I would not be building on someone else's foundation.
Lord, I thank You for all the unique cultures and languages You have created. You know and understand all of them. Thank You that even in places we cannot go, You are there. There is no person that is hidden from Your sight, and no place You cannot reach.
Lord I ask that You would anoint and appoint workers to create relevant, culturally sensitive Christ-centered radio and TV for the
Baloch Lashkrani of Pakistan
. Aid them as they research the culture, and give them divine insight and inspiration in their presentation of the Gospel. I ask that You would bless them with brilliantly creative ideas to communicate Your truth, and that the
Baloch Lashkrani of Pakistan
would be receptive to Your message. I ask Father that You would give the workers favor with people in the media business, and that You would bless them with all the resources, provision, and volunteers they need. Anoint these media presentations to break through the darkness and shine the light of Your truth to the
Baloch Lashkrani of Pakistan
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February 11th, 2013
Could the next pope be from Africa or Latin America?
By Eric Marrapodi and Catherine E. Shoichet, CNN
(CNN) - Hours after Pope Benedict XVI's resignation announcement Monday, speculation was surging over who might be his successor and what part of the world the new pontiff could be from.
The 118 cardinals who will pick the next pope are also in the running for the job. Those cardinals are from around the globe, but more than half of them hail from European nations, according to Vatican statistics.
Worldwide, the demographic trends among the Roman Catholic Church's nearly 1.2 billion members show a different breakdown, with the church seeing only a trickle of new members in Europe, while membership has grown significantly in Africa.
So this time around, could the pope be from Africa, where growth has surged significantly, or from Latin America, a longtime bastion for the church?
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"It's always one of those exciting things. I bet there will be a line in Vegas, there probably already is," said Randall Woodard, an associate professor of theology at Saint Leo University.
"Especially based on the growth of Catholicism and ... the geographic shifts that have taken place, a lot of smart money would be on Africa or Central America."
Some stressed that the pope's geographic background shouldn't be a factor.
"All of the questions about nationalities are nonsense," said Michael Sean Winters, a visiting fellow at the Institute for Policy Research and Catholic Studies. "There are 118 men, and all of them have gotten to know one another. ... Their questions are going to be 'who can we see in that chair?'"
For many in Italy, the choice is already clear, according to John Allen, CNN's senior Vatican analyst.
"Around the dinner tables today in Rome, Cardinal Angelo Scola has the pole position," Allen said Monday.
Scola, an Italian, is the archbishop of Milan.
Canadian Cardinal Marc Ouellet, who heads the Vatican's office of bishops, is also a likely frontrunner, said Allen. And Cardinal Leonardo Sandri, an Argentinian who works as the Vatican prefect overseeing eastern churches, is well-known for his leadership and administrative skills, Allen said.
'The face of Catholicism'
Another top contender for the papacy could be Cardinal Peter Turkson of Ghana, said Woodard, the managing editor of the International Journal of African Catholicism. The 64-year-old cardinal currently heads the pope's council for justice and peace and has experience working with people of different faiths, Woodard said.
"He would be able to respond to global needs and ... the reality of what the face of Catholicism is," Woodard said.
In Brazil - which leads the world with more than 133 million Catholics, according to the Pew Forum on Religion & Public Life - many were buzzing about Benedict's resignation announcement Monday.
"The country has a tradition of Catholicism, and any news related to the pope is very important news in Brazil. ... There are those experts saying that maybe the time has come for a cardinal from the developing world, Africa or Latin America, to ascend to the papacy," said Paulo Sotero, director of the Brazil Institute at the Woodrow Wilson International Center for Scholars in Washington.
Catholic faithful gathered at a religious celebration in Brazil's capital Monday said they were surprised by the news of Benedict's resignation and hopeful that Brazilian Cardinal Joao Braz de Aviz might be picked for the papacy, the state-run Agencia Brasil news agency reported.
CNN's Belief Blog: The faith angles behind the biggest stories
But choosing the next pope is an issue that must rise above geographic borders, said the Reverend Emmanuel Katongole, a Catholic priest from Uganda's Kampala archdiocese who is an associate professor of theology and peace studies at the University of Notre Dame in Indiana.
"Part of the frustration for me is that there is a thinking that Africa's challenges and the opportunities and the interests can only be advanced if we have an African pope," Katongole said. "I find it extremely frustrating when in my vision, the church is a transnational communion of believers whose identity and loyalty cuts across these geopolitical boundaries."
Cardinals prepare to decide
While people outside the church may focus on nationalities and race, within the church's top ranks, cardinals have "a very global vision," Woodard said.
"The pope has to be the visible shepherd of 1 billion Catholics in the world," said Bishop Thomas Paprocki of Springfield, Illinois. "I don't think going into the conclave the pope has to be of a certain nationality."
Other factors are important, Paprocki said, like the age of the next pope.
"It's a grueling and demanding schedule to keep up with," he said.
Pope Benedict, who is 85 years old, said Monday that he will resign at the end of the month "because of advanced age."
"Strength of mind and body are necessary, strength which in the last few months has deteriorated in me to the extent that I have had to recognize my incapacity to adequately fulfill the ministry entrusted to me," the pope said, according to the Vatican.
Age is also a factor for cardinals. Once a cardinal reaches 80, he is no longer able to participate in the election of the pope or enter the secret conclave where cardinals gather to select the next pope.
Of the 118 cardinals of voting age, 28 are from Italy, 34 are from elsewhere in Europe, 19 are from Latin America, 14 are from the United States and Canada, 11 are from Asia, 11 are from Africa and 1 is from Australia.
Cardinals will meet to choose Benedict's successor sometime after his official resignation on February 28, the Reverend Federico Lombardi, a Vatican spokesman, said at a news conference.
"Before Easter, we will have the new pope," he said.
Benedict won't be involved in the decision, Lombardi said. But his influence will undoubtedly be felt. Benedict appointed 67 the 118 cardinals who will make the decision.
It's a choice that Cardinal Donald Wuerl said he doesn't take lightly.
"When we go into the conclave, what has to be upper in the minds of all of us is what is God asking of us in making a choice. Who will fill the chair of Peter? And I think that's going to be the only consideration," said Wuerl, the archbishop of Washington. "Who among this body has the qualifications, the characteristics, the spiritual gifts to fill that chair?"
Wuerl told reporters that he was in his study at 5 a.m. Monday preparing a homily for Ash Wednesday when he found out about the pope's decision.
"This is very startling," he said. "I was totally unprepared for it."
Wuerl is a top American contender for the papacy, according to Allen. Cardinal Timothy Dolan, the archbishop of New York, could also be considered, but both Americans would be on the "C or D list" of candidates, Allen said.
While only the church's inner circle will know what goes on inside the conclave, bookmakers were quick to set the odds over who will be the top contenders.
Two online betting sites listed Turkson as a favorite Monday. London-based William Hill plc and Dublin-based Paddy Power both gave him 3-1 odds.
CNN's Michael Pearson, Hada Messia and Kyle Almond contributed to this report.
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About this blog
The CNN Belief Blog covers the faith angles of the day's biggest stories, from breaking news to politics to entertainment, fostering a global conversation about the role of religion and belief in readers' lives. It's edited by CNN's Daniel Burke with contributions from Eric Marrapodi and CNN's worldwide news gathering team.


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text:
Reduced-Intensity Hematopoietic Stem Cell Transplant for High Risk Lysosomal and Peroxisomal Disorders
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01626092
Recruitment Status : Completed
First Posted : June 22, 2012
Results First Posted : October 11, 2016
Last Update Posted : December 5, 2017
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Lysosomal Storage Disease Peroxisomal Disorder
|Drug: Campath-1H Drug: Clofarabine Drug: Melphalan Radiation: Total Body Irradiation with Marrow Boosting Biological: Hematopoietic stem cell transplantation Drug: Cyclosporine A Drug: Mycophenolate mofetil
|Not Applicable
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|3 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Treatment of High Risk, Inherited Lysosomal and Peroxisomal Disorders by Reduced-Intensity Hematopoietic Cell Transplantation and Low-Dose Total Body Irradiation With Marrow Boosting by Volumetric-Modulated Arc Therapy (VMAT)
|Actual Study Start Date :
|July 11, 2012
|Actual Primary Completion Date :
|November 2013
|Actual Study Completion Date :
|November 2013
Experimental: Intent-To-Treat Patients
Patients with high-risk lysosomal and peroxisomal disorders treated with preparative regimen (Campath-1H 0.3 mg/kg intravenous (IV) on days -12 through -8, clofarabine 40 mg/m^2 IV on days -9 through -5, melphalan 140 mg/m^2 IV on day -4 and Total Body Irradiation with Marrow Boosting [ first dose of 200 cGy single dose; 5 doses of 160cGy for marrow boosting - 1000cGy cumulative exposure] by Volumetric-Modulated Arc Therapy [VMAT] on days -3 through -1). Hematopoietic stem cell transplantation will be infused on Day 0. Post-transplant immunosuppression to follow: Mycophenolate mofetil (MMF) begin day -3 and continue to day +30 or 7 days after engraftment, whichever is later; Cyclosporine A (CsA) begin day -3 and then taper at day +100 if related donor, day +180 for unrelated donor.
Drug: Campath-1H
A daily dose of 0.3 mg/kg IV over 2 hours will be administered on days - 12, -11, -10, -9, and -8.
Other Name: alemtuzumab-1H
Drug: Clofarabine
A daily dose of 40 mg/m2 will be administered IV over 2 hours on days -9,
-8, -7, -6, and -5.
Other Name: Clolar
Drug: Melphalan
A single dose of 140 mg/m2 will be given IV on day -4 over 15 minutes.
Other Name: Alkeran
Radiation: Total Body Irradiation with Marrow Boosting
Other Name: Volumetric-Modulated Arc Therapy (VMAT)
Biological: Hematopoietic stem cell transplantation
Patients will be transplanted using either a related or unrelated allograft. The cell source may be marrow, peripheral blood or cord blood based on donor availability.
Drug: Cyclosporine A
Patients will receive CsA therapy beginning on day -3. Dosing of CsA will be 2.5 mg/kg/dose IV; if the recipient body weight is <40 kg, dosing will be 3 times daily, and if > 40 kg, twice daily. An attempt will be made to maintain a trough cyclosporine level of 200 mg/L to 400 mg/L.
Other Name: CsA
Drug: Mycophenolate mofetil
Patients will receive mycophenolate mofetil (MMF) therapy beginning on day -3. Dosing of MMF will be 1 gram three times daily (total daily dose 3 grams/day) if the recipient is >50 kg, or 15 mg/kg/dose three times daily if the recipient is ≤50 kg. The same dosage is used orally or intravenously.
Other Name: MMF
- Donor (Allogeneic) Hematopoietic Engraftment [ Time Frame: Day 100 Following Hematopoietic Cell Transplant (HCT) ]Number of patients who achieve hematopoietic engraftment - assessment of nucleated peripheral blood cells for donor (allogeneic) chimerism following this reduced-intensity HCT.
- Transplant-Related Mortality [ Time Frame: Day 100 following HCT ]Incidence of death due to complications of HCT following this reduced-intensity conditioning regimen.
- Neurologic Outcomes [ Time Frame: Changes from Baseline, Days 30, 60, 100, Year 1, Year 2, Year 3 Following HCT ]Depending upon underlying primary disease, a combination of evaluative tools (e.g. brain magnetic resonance imaging (MRI), clinical neurologic exam, neuropsychologic testing, electromyography) will be applied for assessment of neurologic function and how it may be affected by this reduced-intensity HCT regimen.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|up to 55 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Adrenoleukodystrophy (ALD): Patients from 0-55 years of age diagnosed with ALD as determined by very long chain fatty acid testing will be eligible for this protocol if they have evidence of cerebral or cerebellar disease based on MRI testing,
- Metachromatic Leukodystrophy (MLD): Patients from 0-55 years of age diagnosed with MLD as determined by arylsulfatase A activity.
- Globoid Cell Leukodystrophy (GLD): Patients from 0-55 years of age diagnosed with GLD as determined by galactocerebrosidase activity will be eligible for this protocol
Wolman's disease, GM1 gangliosidosis, Tay Sachs disease, Sanfilippo syndrome, Sandhoff disease or other inherited metabolic diseases including but not limited to I-cell disease (mucolipidosis II): Patients who are determined to be sufficiently advanced or high risk based on the following reasons:
- Symptomatic disease, as based on neurologic examination or evidence of deterioration based on subsequent neuropsychologic evaluations.
- Evidence of an expected poor outcome based on genetic testing or a prior family history of aggressive disease.
- Other metabolic disorders, including but not limited to I-cell disease, that are deemed to be high-risk for a poor outcome with a standard transplant regimen due to anticipated toxicity based on experience gained at the University of Minnesota or other centers.
Donor Availability
- Transplantation using sufficiently matched related donors (such as matched siblings) or unrelated donors will be considered. Both granulocyte-colony stimulating factor (G-CSF) stimulated peripheral blood grafts and bone marrow grafts will be considered, although bone marrow will be the priority.
- Cord blood grafts, both related and unrelated, are also eligible. As this protocol will use a reduced intensity regimen, this protocol will use the current recommendations of the University of Minnesota for choosing cord blood grafts. If a single cord blood unit cell dose is insufficient, double cord transplantation should be considered if sufficiently matched cord blood units are available. The priority of choosing cord blood donors is based on the current institutional recommendations.
- Exclusion of Metabolic Disorder Carrier Status from related donor and unrelated cord blood grafts as appropriate for primary disease.
- Adequate Organ Function - Measured within 30 days of study enrollment
- Signed consent
Exclusion Criteria:
- Inability to receive total body irradiation (TBI) with marrow boosting per protocol guidelines as determined by the Radiation Oncologist
- Pregnant - Menstruating females must have a negative serum pregnancy test within 14 days of treatment start.
- Advanced Disease Exclusion: Following evaluation, if a consensus of the members of the Inherited Metabolic and Storage Disease Program is that a patient is too advanced to benefit in a measurable and meaningful way from transplant, this will be communicated to the family, and transplant will not be offered.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01626092
|United States, Minnesota
|Masonic Cancer Center, University of Minnesota
|Minneapolis, Minnesota, United States, 55455
|Principal Investigator:
|Weston Miller, MD
|Masonic Cancer Center, University of Minnesota
|Responsible Party:
|Masonic Cancer Center, University of Minnesota
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
MT2011-24 ( Other Identifier: Blood and Marrow Transplantation Program )
|First Posted:
|June 22, 2012 Key Record Dates
|Results First Posted:
|October 11, 2016
|Last Update Posted:
|December 5, 2017
|Last Verified:
|December 2017
bone marrow transplantation
reduced intensity conditioning
Metachromatic Leukodystrophy
Globoid Cell Leukodystrophy
Wolman's disease
GM1 gangliosidosis
Tay Sachs disease
Sanfilippo syndrome
Sandhoff disease
inherited metabolic
I-cell disease
mucolipidosis II
Lysosomal Storage Diseases
Peroxisomal Disorders
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Metabolic Diseases
Mycophenolic Acid
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antifungal Agents
Anti-Infective Agents
Dermatologic Agents
Antirheumatic Agents
Calcineurin Inhibitors
Antibiotics, Antineoplastic
Antineoplastic Agents
Antibiotics, Antitubercular
Antitubercular Agents
Anti-Bacterial Agents
Antineoplastic Agents, Alkylating
Alkylating Agents
Myeloablative Agonists
Antineoplastic Agents, Immunological


text:
This article was originally published in the March/April 1997 issue of Home Energy Magazine. Some formatting inconsistencies may be evident in older archive content.
| Back to Contents Page | Home Energy Index | About Home Energy |
Home Energy Magazine Online March/April 1997
Do New Baseboard Thermostats Save Energy?Ever get frustrated with baseboard thermostats that say colder-warmer or comfort zone? Builders like the low first cost of electric baseboard heat, and manufacturers vie for the builder market with low-cost units. Good controls are often a casualty.
Higher quality electronic line voltage thermostats (ELVTs) have been available for several years. Most models indicate temperature in degrees, and they're touted as energy savers. But how well do they work? Do savings warrant replacing old thermostats? In Oregon, the Portland Energy Office (PEO) asked these questions. The result was a test of two no-frills ELVTs--Cadet TDLV-240H and Honeywell T4800--as retrofit baseboard thermostats.
A good thermostat should keep room temperature within a degree of the setting. Bimetallic central heating thermostats can do this at 24 volts, but they carry only enough current to operate a relay. Older baseboard thermostats also use a bimetallic element. It senses temperature and switches heater current--two conflicting jobs. The bimetal strip must respond rapidly to temperature changes, and be robust enough to switch currents that sometimes exceed 20 amps without overheating. Mishandled, this compromise can cause excessive hysteresis--temperature swings above and below the setpoint. Droop--lowered setpoint as the heater nears full-time operation--can also be a problem.
ELVT development was sponsored by the Electric Power Research Institute (EPRI). ELVTs avoid the compromise inherent in bimetal thermostats by separating sensing and switching. A lightweight thermistor senses temperature; semiconductors control heater current. Laboratory tests show low hysteresis and droop.
In theory, ELVTs save energy by maintaining comfort at a lower average temperature. Figure 1 shows how two thermostats maintain the same minimum temperature with different setpoints. The higher hysteresis of the bimetal thermostat forces a higher setpoint to get the same minimum temperature. The assumption is that people set thermostats to keep temperatures above their minimum comfort level. If this is true, ELVTs will lower average temperatures by half the difference between the two thermostats' hysteresis.
However, unless people really do set their thermostats to maintain a minimum temperature, savings may not occur. Also, Figure 1 oversimplifies thermostat use. Real-world effects include night setback, heat turn-down during absences, and many other behavioral factors.
Previous field tests have assumed constant thermostat settings for evaluating ELVTs. But PEO needed to be convinced that savings were a realistic expectation, without assuming set and forget operation. Through winter-long testing, we compared ELVTs to original-equipment bimetal thermostats in 27 two-bedroom apartments.
We controlled for random effects of occupant behavior and weather. Both old and new thermostats were used by the same occupants, each for two months of the winter. Each family was its own control group, to ensure that measured differences were thermostat related. To avoid self-fulfilling expectations, occupants weren't told that the ELVTs were energy savers.
Data loggers monitored whole-apartment power, baseboard zonal power, and zonal temperatures near thermostats. We also made unique measurements, crucial to the test, of zonal setpoint and hysteresis. The Data-Trap loggers we used can record event-specific or condition-specific data. We programmed them to record instantaneous temperatures when the baseboards turned on and off.
Results were a mixed bag. ELVTs provided excellent temperature control accuracy compared to the bimetals. After the test, several families asked for reinstallation of ELVTs that had been replaced by original thermostats. However, the original thermostats weren't uniformly poor.
ELVT manufacturers' literature suggests that typical bimetals had hysteresis of about 6°F, as shown in Figure 1. But hysteresis actually averaged only 2.5°F, reducing savings expectations by 65%. One of the three apartment complexes--19 of 27 units--had reasonably good bimetal thermostats, averaging 1.4°F hysteresis. Our test protocol dictated that they should be retrofitted; otherwise we wouldn't have bothered.
ELVT hysteresis averaged 0.6°F, with minor variations. Most occupants favored ELVTs. As theory predicted, setpoints were lower with the ELVTs, by about 0.9°F. If this had been the only change due to ELVTs, annual savings would have been about 220 kWh per apartment-year ($14 per year at 6.5¢/kWh).
But the energy performance results were initially baffling. To our surprise, average inside temperature (and therefore energy use) didn't decrease with ELVTs. How, if setpoints decreased and everything else stayed the same, could average temperature not decrease?
Our data showed that most occupants used some night setback. Daily highs and lows differed, on average, by about 2.2°F, ranging from 0.4°F to 6.1°F. These occupants just weren't set and forget types! Further checking showed that the use of night setback changed when thermostats were switched. With ELVTs, occupants didn't turn temperatures down as much overnight as they did with bimetal thermostats. The result: no statistically demonstrable energy savings. But this wasn't the whole story.
Instead of energy savings with ELVTs, we found a significant reduction in peak demand. This was partly because the heaters didn't run as long to achieve morning warm-up, due to the reduced setback with ELVTs.
To determine how setback affected savings, we split our sample of bimetal users into a low-setback half and a high-setback half. The high-setback group showed greater demand reductions, but no energy savings, with ELVTs. The low-setback group showed smaller demand reductions, and some evidence of energy savings, with ELVTs.
Unanswered behavioral questions remain. For example, some occupants turned the heat off--not down--at night with bimetals. Faced with obscure choices (Do I turn it down to the c or the m in 'comfort zone'?), did occupants simply turn off the heat? With ELVTs, and real temperature settings to choose for setback, did they choose logical, but higher, setback temperatures? Or were bimetals turned off to avoid overwarm sleeping temperatures?
For people who are considering retrofitting baseboard thermostats, here's what we recommend:
--Les LambertLes Lambert is president of Lambert Engineering Incorporated, in Bend, Oregon. Lambert Engineering manufactures Data-Trap loggers and controls.
| Back to Contents Page | Home Energy Index | About Home Energy |
Home Energy can be reached at: firstname.lastname@example.com
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text:
Letter: Public not informed on airport process
Staff Writer
To the Editor:
I concur with the recent letter opposing the Oak Ridge airport.
So far, the process for an airport has been out-of-sight and shielded from public input. It appears the Chamber of Commerce, various economic development boards and councils, and unknown business owners and individuals have been working behind closed doors to make this happen.
Our City Council has not kept us informed nor solicited our input. It appears that those responsible for transforming the vacant land around K-25 have finally found a use for it after failing to recruit businesses to settle there.
Alfred Wohlpart
Oak Ridge


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Mark van Doren once said: "A good teacher is one who makes himself progressively unnecessary." Susie Fishbein – that quintessential teacher – is looking to wean devoted Kosher by Design cooks, off the book and onto self-actualization in the kitchen with her new cookbook "Kosher by Design Cooking Coach."
With over 400 full-color pictures by the talented John Uher, 10 pictorial coaching sections and a cross referenced index of 120 new recipes, this 8th title in ArtScroll's Kosher by Design series, imparts essential skills, techniques, tips and tools to help us excel in the kitchen. Cooking Coach includes sections on essential kitchen equipment, why 3 culinary knives will do the trick, key tips on buying and preparing fish, meat, chicken and side dishes, and my favorite, an easy to follow playbook of recipe variations that help stretch the budget without being mealtime boring or left-over repetitive.
The lay out is so picture laden and easy on the eye it could pass for an idiot's guide to the kitchen were it not for its elegant descriptive content. I think what we all love about Susie most and what's made her series such an enormous success, is her ability to deliver fool-proof recipes that are delicious and make us look like culinary heroes to our family and friends. In this latest cookbook, Susie wants to up the ante and move her loyal audience beyond the written recipe, teaching us essential skills to help us develop, discover and explore our own creative cooking abilities beyond the text and within our own selves; the ultimate gift of a true teacher.
From the book, page 184:
Used by permission: ArtScroll Shaar Press
Yield: 4 – 6 servings
Bulgogi is Korea's most famous street food. It is also served in homes and restaurants, prepared on tabletop hibachi-style grills.
The key to this dish is slicing the meat paperr thin so it absorbs all the flavors of the marinade and cooks quickly. If you freeze the meat for 30-45 minutes out of it packaging in a piece of foil or parchment, it will be much easier to slice nicely.
- 8 cloves fresh garlic, sliced
- 2 tablespoons soy sauce
- 2 tablespoons dark brown sugar
- 2 teaspoons rice vinegar
- 1 teaspoon Worcestershire sauce **
- 1/4 teaspoon cayenne
- 1 1/2 pounds filet split, cut into paper thin 1/16 inch slices
- 1 head Bibb or Boston lettuce, separated into leaves.
Dipping Sauce
- 1 cup soy sauce
- 2 teaspoons honey
- 2 tablespoons fresh ginger, peeled and minced
- 1/2 teaspoon roasted or toasted sesame oil
- 1/4 teaspoon red pepper flakes
- In a medium bowl mix the garlic, soy sauce, brown sugar, vinegar, Worcestershire sauce, and cayenne. Add the sliced steak. Toss and stir to separate the slices and make sure they are well coated. Allow to marinate at room temperature for 15-20 minutes.
- Heat 1 tablespoon canola oil in a large in a large skillet over medium heat. Remove the meat from the marinade and discard any remaining marinade. Sear the meat, in a single layer, allowing room between slices, you may need to do this in batches. If so, wipe out the pan between each batch and heat a bit more. oil. Don't move the meat around. Get some good caramelization and then, using tongs, turn each slice over and repeat on the second side, 3-5 minutes in total cooking time.
- Roll 1/2 cup meat in a Bibb lettuce leaf. Repeat until all the meat is rolled. Transfer to a plate or a platter.
- In a small bowl, prepare the the clipping sauce. Whisk together the soy sauce, honey , ginger, sesame oil, and red pepper flakes.
** True Worcestershire sauce contains anchovies. If the kosher certification mark stands alone, then the percentage of anchovies is less than 1.6% of the whole product. Many rabbinical authorities say that this is okay to use with meat. If the kosher certification is on the label has a fish notation next to it, the level exceeds 1.6%; do not use it in meat dishes.
Page 27, in the Playbook section, lists what you can do with the leftovers of the above recipe:
Make a tasty ASIAN BEEF SOUP with your leftovers: In a soup pot, heat 1 tablespoon canola oil. Add 1 sliced onion, 10 sliced shiitake mushrooms, and 2 teaspoons fresh grated ginger. Sauté until the mushrooms and onion sare wilted. Add 6 cups chicken stock. 1/4 cup shredded carrots, a handful of pea pods, and 1 thinly sliced stalk bok choy. Bring to a simmer; cook for 10 minutes. Mix in 1 tablespoon soy sauce, 1/2 teaspoon roasted sesame oil, and 1 teaspoon sriracha chilli sauce. Chop the leftover bulgogi and add to the pot along with 2 scallions thinly sliced on the diagonal.
Enjoy, enjoy!


text:
WELCOME TO CLINICAL FUTURES | A CHOP Research Institute Center of Emphasis
Clinical Futures, formerly the Center for Pediatric Clinical Effectiveness (CPCE), is powering progress in pediatric care. As a Center of Emphasis within the Children's Hospital of Philadelphia (CHOP) Research Institute, one of the largest pediatric research institutes in the country, we are committed to improving the care delivered to children. The center consists of dynamic multidisciplinary teams of clinicians, researchers, biostatisticians, and public health experts dedicated to advancing the conduct and outcomes of clinical research for children.
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Mechanics gear up for hot-selling hybrids
Chuck Kurt loved his hybrid car so much, he got one for his wife.
But you might be lucky just to find one.
With gas prices north of $3 a gallon and more consumers going green, the part-electric vehicles are rolling off lots faster than dealers can order them.
The most popular is the Toyota Prius, which sold a record 24,009 cars in the United States last month. And if you can find one on a lot, chances are the car already has a deposit on it, said Devin Bloomingdale, sales manager for Anderson Toyota in Rockford.
Demand Exceeds Supply
"Right now, there's a waiting list for all hybrids, and it's going to be that way for a while," Bloomingdale said.
It's the same story at Napleton's Auto Werks in Loves Park, where the Honda Civic hybrid is popular. There was a spike in sales when gas topped $3 in late 2005, Honda sales manager Jorge Rangel said, but that was nothing compared with last month's spike when gas hit $3.50.
"A lot of them are coming in sold before they come in here," he said. "Even the pre-owned hybrids, as soon as I get them, they're sold."
Dealers say most customers are interested in saving money on gas, but they note that it takes a few years to recoup the investment in the vehicles, which cost thousands more than comparably equipped gas-only vehicles. Drivers who have longer commutes will see savings a lot quicker.
But more and more customers are also looking for an alternative to fossil fuels, regardless of the money savings.
Small Share of Business
"I think it's the wave of the future," said Kurt, who owns Kurt's Auto & Truck Center in Rockford. "Whatever we come up with in the future as we run out of renewable resources, I think it's going to be a package of electrical and other things."
Mechanics like Kurt are also seeing more hybrids, but it's still a tiny piece of their business. Hybrids make up only about 1 percent of the domestic auto market.
Kurt compares them to import cars -- decades ago, a lot of mechanics wouldn't touch them, but now everyone works on them.
Dealer shops still do the lion's share of the work, especially anything dealing directly with the electric components. That's partly because the vehicles are still new and under warranty, and partly because dealer technicians have access to company-provided classes that give an inside look at their vehicles.
But with the expectation that hybrids will get a bigger share of the markets, even independent mechanics are buying special gloves and equipment and taking classes.
"Most of the work we have done on them is nothing hybrid-related," said Greg Gerber, shop manager at Harlem Road Automotive in Loves Park. "We're mainly doing things like plugging tires, doing brakes. The schooling that we've gone to, they're telling us that the manufacturers want those cars to go back to the dealership so they can see how they're doing."
The biggest difference in handling hybrids is minding the electrical current, which is typically a few hundred volts. Hybrids tend to have the electrical cables shielded in bright-orange insulation, and mechanics are taught how to power the vehicle down before working on them.
Bob Hall, owner of Advanced Automotive Services in Machesney Park, said his staff will do more training as the vehicles become more popular. He's even considered buying one for himself, but he's concerned about long-term costs of repairing the vehicles and their complex components.
"Once you get into repairing motors for both hybrid and gasoline, you've got double the powertrain and the batteries are real expensive," he said. "Once they get old, people will junk them instead of paying for repairs."
Honda and Toyota say the batteries should last the life of the car, and they say the replacement costs of batteries keep dropping. They also have battery-recycling programs to allay environmental concerns, and Toyota specifically pays dealers a "bounty" for each battery they send to recycling.
Kurt thinks many of the concerns will be proved false -- he too thought the batteries would last only a few years until he did some research. Now he's a convert.
Other companies appear to be, too, with Lexus and GM coming out with hybrid vehicles. Kurt expects to see them in his shop someday, too.
"I've always been trying to be forward-looking," he said.
Contact Thomas V. Bona at email@example.com.
The next innovation in hybrids is expected to come from a new type of battery, called the lithium-ion battery, which will be smaller and lighter than the nickel-metal hydride batteries Toyota now uses for its hybrids.
A major breakthrough is needed to switch to lithium-ion batteries, now widely used in laptops, to make them power cars.
Earlier this month, General Motors Corp. announced another step to get its Chevrolet Volt long-range electric series-hybrid vehicle into the hands of drivers.
GM awarded two contracts for advanced development of lithium-ion batteries for the Volt to Michigan-based Compact Power Inc., a subsidiary of Korean battery manufacturer LG Chem. and Continental Automotive Systems, a division of Continental AG.
-- Register Star wire reports
May was the biggest month ever in U.S. sales of hybrid vehicles. The top-selling models were:
Toyota Prius, 24,009
Toyota Camry, 6,853
Honda Civic, 4,520
Toyota Highlander, 3,312
Mercury Mariner and Ford Escape, 3,214
Lexus Rx 400h, 1,746
(Note: General Motors doesn't break down the sales of hybrid versions of its vehicles)
-- Register Star wire reports


text:
WASHINGTON – The federal budget deficit will drop below $1 trillion for the first time in President Barack Obama's tenure in office, a new report said Tuesday.
The Congressional Budget Office analysis said the government will run a $845 billion deficit this year, a modest improvement compared to last year's $1.1 trillion shortfall but still enough red ink to require the government to borrow 24 cents of every dollar it spends.
The agency projected that the economy will grow just 1.4 percent this year if $85 billion in across-the-board spending cuts take effect as scheduled March 1. Unemployment would average 8 percent. Obama wants to ease the cuts by replacing them with new tax revenue and alternative cuts, but a clash is looming with Republicans who insist that last month's tax increase on wealthier earners will be the last tax hike they permit.
The report predicted the deficit would dip to $430 billion by 2015, the lowest since the government posted a $459 billion deficit is former President George W. Bush's last year in office. That would be a relatively low 2.4 percent when measured against the size of the economy.
But as more and more baby boomers retire and claim Medicare and Social Security and as Obama's health care law takes effect, deficits would move higher and again reach near $1 trillion in the latter portion of the 10-year window – despite the recently enacted tax increase on family income exceeding $450,000 and automatic spending cuts of about $100 billion a year. The package of spending cuts and tax increases are punishment for Washington's failure to strike a long-term budget pact.
'We need to continue working to cut spending responsibly, protect and strengthen programs like Medicare, and raise revenue by closing tax loopholes that the wealthiest Americans and biggest corporations take advantage of,' said Senate Budget Committee Chairman Patty Murray, D-Wash.
Over the coming decade, the deficit would total $7 trillion but would move higher if lawmakers extend expiring business tax breaks and rescue doctors from cuts to their reimbursements under Medicare.
The report provided fresh fodder for Washington's familiar battles over the budget, deficits and debt. Obama inherited an economy in crisis and first-ever deficits exceeding $1 trillion. The 2009 deficit, swelled by the costs of the Wall St. bailout, hit a record $1.4 trillion, while the deficits of 2010 and 2011 both registered $1.3 trillion.
Economists say that too-high deficits and debt are a drag on the economy and could eventually precipitate a fiscal crisis like many European countries are experiencing.
'The CBO's report is yet another warning that we need to get spending under control. The deficit is still unsustainable,' said House Budget Committee Chairman Paul Ryan, R-Wis. 'By 2023, our national debt will hit $26 trillion. We can't let that happen. We need to budget responsibly, so we can keep our commitments and expand opportunity.'
Ryan promises his upcoming budget plan will balance by 2023, but that would require spending cuts of almost $1 trillion in that year alone.
The economy will grow slowly in 2013 and more rapidly next year, with unemployment projected to stay high, according to the report.
This year's growth is being hampered by a tax increase enacted in January and by automatic spending cuts scheduled to take effect this spring. CBO projects the economy will grow by just 1.4 percent this year but recover to 3.4 percent next year.
Unemployment is projected to stay above 7.5 percent through next year. That would be the sixth straight year above that level, the longest period of such high unemployment in 70 years, the report said.
Without the government's fiscal tightening, which includes the expiration of Obama's two-year, 2 percentage point cut in payroll taxes and the imposition of the automatic spending cuts, economic growth would be about 1.5 percentage points higher this year, the report said. However, CBO warns that future growth would be constrained if the government doesn't reduce future deficits.
The report warns that actual deficits could easily be higher since CBO is required to assume Congress sticks to the letter of the law.
The report says that health spending will continue to grow as Obama's health care law takes full effect. CBO said spending on major health care programs will surpass Social Security in 2014, as Obama's push to cover the uninsured goes into high gear. Major health care programs include Medicare, Medicaid, children's health insurance and the new subsidies to help uninsured Americans get coverage.
Although health care costs remain a major problem for the budget, a slowdown in the growth of medical spending is helping take away some of the immediate pressure. In 2012, federal spending for Medicare and Medicaid was about 5 percent below what CBO had projected only two years earlier. As a result, the agency has trimmed its long-range cost projections.
CBO also estimates that fewer uninsured people will get coverage under the health care overhaul – about 4 million fewer Americans. And about 7 million fewer will be covered by job-based health plans.
Tuesday's estimate says the health care law will reduce the number of uninsured by about 27 million people in 2022, as compared to last year's estimate of around 30 million fewer uninsured. CBO said it expects some people will be slow to take the new coverage when it becomes available in 2014, but that demand will pick up within a few years.
CBO also said it expects more employers to get out of the business of providing health insurance, particularly for low-wage workers, and instead pay fines to the government. Although employer-provided coverage will remain the mainstay for most employees, in 2022 there will be 7 million fewer covered by job based plans, the agency said.


text:
Alex Puccio Third, Stöhr and Sharafutdinov Win Vail World Cup
Roughly 1,000 spectators erupted on Saturday evening as American Alex Puccio latched the top jug of the women's final problem and cranked a celebratory pull-up at this year's IFSC Bouldering World Cup in Vail, Colorado.
Roughly 1,000 spectators erupted on Saturday evening as American Alex Puccio latched the top jug of the women's final problem and cranked a celebratory pull-up at this year's IFSC Bouldering World Cup in Vail, Colorado. Puccio, who was tied for first place with Austrian Anna Stöhr and Akiyo Noguchi of Japan, managed to place third at the only bouldering World Cup held on U.S. soil.
"I had it in the bag a little bit and messed up," Puccio explained to a Vail Daily reporter after the event. "I got messed up on the starting holds." Despite the mix up, Puccio still managed to send the evening's fourth and final problem on her second try, sealing a coveted spot on the podium.
However, Akiyo Noguchi–who was also initially stymied by the final problem's beginning sequence–shocked the crowd on her last attempt by flawlessly executing the problem with no time left on the clock, to effectively break the tie with Puccio (due to Noguchi's Semi-Finals points) and nab second place. Perhaps the strongest female performance of the evening, however, came from Anna Stöhr, who managed to top out all four boulder problems of the final round and clinch the victory of her 19th bouldering World Cup.
The men's competition "was tough" said American Paul Robinson, who was one of six competitors out of 40 total men to make the finals. Robinson's eyebrows lifted as he watched the Russians Dmitrii Sharafutdinov and Rustam Gelmanov power through the evening's final problem. "That problem is about V10 or V11," said Robinson. "Probably V11."
Sharafutdinov and Gelmanov were the only competitors to send the slopey, final problem–with Sharafutdinov cranking it second try. He explained after the event that he enjoyed the intense difficulty of Vail's World Cup Bouldering competition. "It was challenging," said Sharafutdinov who took first place, while Gelmanov took second. Jorg Verhoeven of the Netherlands managed to edge out Canadian Sean McColl and Austria's Kilian Fischhuber by onsighting Men's Problem 3 to take third. "Although I failed on all slab problems today, I just had so much fun climbing," commented Verhoeven on Facebook.
Men's Top 10 Results:
1 SHARAFUTDINOV Dmitrii RUS
2 GELMANOV Rustam RUS
3 VERHOEVEN Jorg NED
4 MCCOLL Sean CAN
5 FISCHHUBER Kilian AUT
6 ROBINSON Paul USA
7 KRUDER Jernej SLO
8 CALEYRON Thomas FRA
9 SCHUBERT Jakob AUT
10 WOODS Daniel USA
Women's Top 10 Results:
1 STÖHR Anna AUT
2 NOGUCHI Akiyo JPN
3 PUCCIO Alex USA
4 COXSEY Shauna GBR
5 WURM Juliane GER
6 PAYNE Angela USA
7 SAURWEIN Katharina AUT
8 LE NEVE Melissa FRA
9 SETHNA Elise CAN
10 ONOE Aya JPN


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1 oz. Homeopathic remedy for Chronic Fatigue and Exhaustion
For symptoms of Endometritis, Endometriosis and lower abdominal pain associated with female problems.
You do not have to suffer from the pain associated with these conditions. Endo-Quest helps stimulate your body to get rid of the excess cellular tissue which is at root of the problem.
Note: This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease
For symptoms of Colitis, Irritable Bowel, Diverticulosis and Chrons.
Entero-Quest stimulates your body's defense mechanisms to eradicate the virus/bacteria and pH conditions which allow bowel conditions to develop.
Some people have reported complete elimination of symptoms in 1-2 weeks.
Note: This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease
For general female problems throughout the month.
For symptoms of fibroids.
A remedy for the Gender Wars. Designed to enable a woman to feel empowered to be feminine and to strengthen feelings of security, strength, and wholeness in her relationships with the men she loves.
A Homeopathic Formula designed for symptoms of Low Thyroid function.
Vax Effects
1 oz. Homeopathic remedy to assist the body in fighting effects from the corona/covid Vax.
A homeopathic remedy for painful menstrual problems, including PMS.
Thin-Quest is designed to assist your body in realizing that there is a weight problem, and that the body should address it. Using its natural systems the body will then begin to re-regulate the weight downward toward a weight level natural for your frame.
This formula is designed with the ability to be potentiated by placing it next to orgonite, so as to increase the bioenergy within Thin-Quest, such as with ChemBuster.
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What is a Dermatologist?
Our team of professionals and staff believe that informed patients are better equipped to make decisions regarding their health and well-being. For your personal use, we have created an extensive patient library covering an array of educational topics, which can be found on the side of each page. Browse through these diagnoses and treatments to learn more about topics of interest to you.
As always, you can contact our office to answer any questions or concerns.
A dermatologist is a physician who specializes in the treatment of skin conditions and diseases. Dermatologists are certified by the American Board of Dermatology after extensive education and medical residency. They treat everything from minor skin rashes, like hives, to chronic skin diseases, such as eczema or psoriasis. Dermatologists are good diagnosticians and can distinguish between conditions that share similar symptoms. Today many dermatologists are also well versed in cosmetic dermatology procedures to help improve the appearance of skin as we age.


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TNB: Chasing the Devil's Snort
Years ago, before the invention of the chocolate-covered espresso bean, I started each morning at a bivy by eating coffee grounds, and at times would carry a stove and espresso maker to the crag, both for enjoyment and as a guarantee. It is not far fetched to say that drinking coffee is as important to your climbing success as dusting your hands with chalk. If I could only have one, I'd choose coffee.
Coffee is nature's greatest gift. The magical "black water," as noted by the French writer Balzac who at times drank 50 cups a day, "sets the blood in motion and stimulates the muscles; it accelerates the digestive processes,
chases away sleep, and gives us the capacity to engage a little longer in the exercise of our intellects."
2.25 billion cups of coffee are drunk each day, making it the second-most valuable traded commodity in the world, edged out only by petroleum.
The effects and benefits of coffee on athletic performance are well known, yet it is one performance-enhancing substance not banned by the World Anti-Doping
Agency. Drinking coffee will make you run harder and faster and longer, and in my stringently scientific research, climb harder and be happier while
doing so. Years ago, before the invention of the chocolate-covered espresso bean, I started each morning at a bivy by eating coffee grounds, and at
times would carry a stove and espresso maker to the crag, both for enjoyment and as a guarantee. It is not far fetched to say that drinking coffee
is as important to your climbing success as dusting your hands with chalk. If I could only have one, I'd choose coffee.
Some people would view the consumption of coffee as unethical, even diabolical. For a time during the Ottoman dynasty the dark bean was judged as the work
of the devil. Drinkers were sewn into sacks and thrown into the Bosphorus river.
I prefer the position of Pope Clement VIII. When pressured by his minions to declare coffee "the bitter invention of Satan," the Pope tasted a brew and
found it so delicious he proclaimed that, "we shall cheat Satan by baptizing it."
It was with this background that I recently traveled to the Intag Valley, a cloud forest
in the foothills of Ecuador's Andes mountains, an enchanting place where a small cooperative produces Arabica beans said to be among the world's finest.
For me as a coffee drinker, the trip was like discovering the source of the Nile. As a climber, learning the secrets of the mysterious coffee was like
being inducted into the Illuminati.
Getting to the Intag required over two hours of potholed dirt road that switched along the green and often vertiginous slopes, passing innumerable and
spectacular waterfalls and a soccer field.
The drive was fraught with peril. At one point, an earth-mover with tracks the size of baby elephants used its bucket to whack an enormous boulder that
tumbled onto the road.
In the valley bottom and after crossing an ancient
swinging footbridge that spans a cauldron they call the Rio Intag, I met Jorge. Ripped with sinew and veins and well tanned by decades under the Equatorial
sun, Jorge could pass for a serious climber. He is instead a serious grower of the coffee bean. Jorge has 2,400 coffee plants tucked in the shade of
avocado, pineapple, mango, papaya and banana trees, and a curious other tree that I'd never seen but whose fruit had the texture of cotton and tasted
like sugar. At 0 degrees latitude the region is exceptionally fertile. Even at 6,000 feet elevation, the Intag's nearly steady year-round temperature
and the fertile volcanic soil make this one of the most biologically diverse places on earth. Seventeen percent of the world's plant species and 20
percent of the bird diversity is here. The Intag is also the home to rare and elusive animals such as the spectacled bear, the last indigenous bruin
still alive in South America, and the dwarf deer.
Trees sprung from the steep and muddy slopes and I had to cling my way from tree to tree up the hillside. This was a surprise, as I had imagined a coffee
farm as flatlands, the plants growing in economical rows that could easily be harvested by big machines with forked fingers.
Until I visited Jorge I'd been to different manufacturing outfits and watched awestruck as robotic looms spun ropes, forges heated and stamped aluminum
into carabiners and cobblers painstakingly stitched and glued rock shoes. Each time I'd been impressed by the labor and knowledge that went into producing
the gear, and went home amazed that while we continuously complain about prices, we are fortunate that climbing gear is made at all. I would like to
report that producing a coffee bean requires no less care and expertise and if we had to grow our own plants and process the beans through to coffee,
its cost would equal that of saffron.
Every misty day during harvest season Jorge clings to his slopes, gently clearing the night's overgrowth of unwanted plants with a sweep of the machete.
He examines the coffee plants and picks the red berries one at a time. Since coffee berries don't all ripen at the same time, he must repeat this task
each day for about three months. How he could even find the plants amid the green tangle is a mystery solved only by years of familiarity. Imagine
all the route beta you have committed to memory and you get an idea of how dialed Jorge has his fields.
To get a coffee plant to even grow, requires Darwinian knowledge. First Jorge must sterilize the ground with boiling water. He then plants a seedling,
nestled as I noted earlier only in the shade because direct sunshine spoils the flavor of the bean. During the dry season he must hand water each plant,
running piping down from a source hidden somewhere up in the clouds. After two or three years of being carefully pruned and nursed the coffee plant
begins producing fruit called cherries. Once these are ripened red and picked, they are fermented in a basin of water. The bad beans float to the top
and are scooped out by Jorge. He next runs them through what looks like an old-fashioned clothes wringer, but one that strips off the outer fruit,
leaving the green coffee beans. These are dried in the shade then sold to Café Rio Intag where the beans are fed into another machine to remove the
the paper-like coating called parchment, then cured, sorted one bean at a time by hand, roasted and bagged. For his part Jorge is paid about $1.50
pound. One coffee plant produces up to one and a half pounds of beans.
I bought two pounds of green coffee beans from Jorge and bore them quickly back to Colorado. A trip to WalMart produced a popcorn air popper for DIY coffee-bean
roasting. The beans hadn't been fully processed—the parchment had to be painstakingly picked off each bean by hand before roasting. After 30
minutes of cleaning, my fingers were adequately sore and I had enough beans for one cup of coffee ready for the air popper. The roasting was harder
and messier and smellier than I had pictured and for a moment, probably when the half-roasted beans and burned parchment blew across the kitchen counter
and the room filled briefly with smoke, I questioned the wisdom.
Happy thoughts returned, however, as I tamped the grounds into the espresso maker's portafilter and hit the on button. I stood mesmerized as double jets
of creamy brown foam spewed from the machine's nostrils and into my eager cup. It was like watching a dragon snort. The brew was complex, with earthy
notes of Intag's volcanic dust and a buttery aftertaste. I sank into a leather chair and sipped, eyes pinched shut, and let the coffee do its work.
To paraphrase Balzac, sparks shot up into my brain, ideas quick-marched and memories charged in. I imagined Jorge up there on that Andean hillside,
his knotty fingers lovingly caring for each plant. Giving them names. Almost as if they were routes.


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My Memories of a Future Life
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The Undercover Soundtrack – Pete Lockett
Posted by Roz Morris @Roz_Morris in Undercover Soundtrack on April 23, 2014
'The moment of making the first sound or writing the first word is special'
Once a week I host a writer who uses music as part of their creative environment – perhaps to connect with a character, populate a mysterious place, or hold a moment still to explore its depths. This week my guest is award-winning percussionist Pete Lockett @petelockett
Soundtrack by Pete Lockett with Björk, Peter Gabriel, Robert Plant, Dido, Bill Bruford, Jeff Beck, Ustad Zakir Hussain, The Verve, Texas, Trans-Global Underground, Nelly Furtado, Lee Scratch Perry, Primal Scream, Damien Rice, Dave Weckl, Thomas Lang, Jarvis Cocker, Craig Armstrong, Nicko McBrain, Iron Maiden, U Shrinivas, Ronan Keating, Vanessa-Mae, Errol Brown, Rory Gallagher, Pet Shop Boys, Hari Haran, Kodo, Amy Winehouse, Mel C, A R Rahman, Sinead O'Connor
This music is just incredible; I've never heard anything like it before."
I doubt if anyone outside of this community ever has. This is what you get when Brahms and Bach have been living next door to one another for hundreds of years.They don't even use notation any more.They've just devised a way to conduct the whole group with nods, looks and head shakes.Look, can you see them there at either side? Bach is doing all the spiky staccato stuff and Brahms is doing the smooth legato.It's all totally improvised and will never happen again. Every rendition is completely different.They both claim that it is the highest level of composition one can reach.Instantaneous composition, conducting and performance."
When Ed Trew wakes up with a killer hangover, little does he realise that it is the beginning of a mind-boggling journey of revelations and surprises that completely reshapes his view of the world. In the midst of chaos and confusion he becomes completely seduced by music.
It's no surprise that music and the arts so often act as a liberating influence, giving some lucky individuals the chance a world of creativity and hope. I am grateful to fate to have been propelled out of an ordinary, functional and less than satisfying existence. Music came and lifted me away and showed me a path towards self fulfilment where my mind could become a canvas for fresh ideas. Everything about music fascinated me and as I grew, I slowly started absorbing influences from every corner of the globe, from India to Africa and Nepal to New York – the systems and techniques, sounds, colours and moods. It also led me to a much deeper understanding of people, their motivations, formalities and habits. The way people make music reveals a lot about the culture from which they have flourished.
This 'open plan' consumption and integration of varied influences naturally became a cornerstone of my writing when I finally got around to penning a novel. Having had a great degree of freedom in my interpretation and mixing of musical styles, it was natural that this approach got carried over into ideas and stories.
When I sit down and compose music, I start with nothing. That moment of making the first sound or writing the first note is always special, all the more so because I have no idea where it is going to lead. This influenced me directly to try the same thing with words, to take a simple starting point and embark on a journey, not knowing where or how I would get between the various points along the way.
Creative dialogue
I knew I wanted to have the same freedom that I find in music, able to bring together seemingly disparate concepts and make a new sense out of it all. To be unbound by all that is 'normal' but convincing enough to create a dialogue that stands up under scrutiny. As I wrote more and more, I was amazed about how similar the creative buzz was between both of them. I never thought I would find anything that gave me the spiritual lift that music making did but was convinced otherwise during the writing of A Survivor's Guide to Eternity.
Just as I would embark on so many journeys with my work as a musician, so the character in my book is thrown headlong into an incredible journey, except his is through life, death, reincarnation and the afterlife. Little does he realise that it's the beginning of a mind-boggling journey of revelations and surprises that completely reshapes his view of the world.
Structure and suspense
Once I really started to get into it, the writing and music began to feed one another even more in quite an inspiring way. A good gig would send me straight back to the hotel with my laptop to get writing and vice versa. I began to think through certain pieces of music and see how the suspense built up over a set time frame, keeping the listener engaged and waiting for the next development. Indian classical music is perfect for that, especially over long periods of time. I began to experiment to see how I could mirror that in my storytelling, sowing seeds and planting suggestions, but all the while keeping the reader impatient for the detail of the next development. As I thought about it, more and more parallels became apparent between literature and music.
Before I knew it I was unconsciously taking on board the broad shapes of pieces of music, flowing like a river around bends and over rocks, sometimes calm and sometimes ferocious. It gave me a great insight into how to approach the timeline within the novel, sometimes going slowly and patiently before propelling it through rapids and over rocks down towards a calming resolution.
There's so much in common between the two disciplines. One tells a story with words and the other with sound. We need to keep the listener/reader interested with suggestions but not in a way that paints an obvious picture. We need to create suspense, excitement, anticipation and resolution. I never thought they would be quite so interlinked.
Pete Lockett has recorded and/or performed with Björk, Peter Gabriel, Robert Plant, Dido, Bill Bruford, Jeff Beck, Ustad Zakir Hussain, The Verve, Texas, Trans-Global Underground, Nelly Furtado, Lee Scratch Perry, Primal Scream, Damien Rice, Dave Weckl, Thomas Lang, Jarvis Cocker, Craig Armstrong, Nicko McBrain (Iron Maiden), U Shrinivas, Ronan Keating, Vanessa-Mae, Errol Brown, Rory Gallagher, Pet Shop Boys, Hari Haran, Kodo, Amy Winehouse, Mel C, A R Rahman, Sinead O'Connor and many more. He arranged and recorded ethnic percussion for five Bond films and other Hollywood blockbusters and has taught and lectured worldwide, including The Royal College, Berklee School of Music Boston, and The Royal Academy of Music in London. He is the author of Indian Rhythms for the Drum Set (Hudson). A Survivor's Guide To Eternity is his first novel. Here he is on a mountain with percussionist Benny Greb. Find him on Twitter @PeteLockett
A R Rahman, A Survivor's Guide to Eternity, Amy Winehouse, authors, Bill Bruford, Bjork, Craig Armstrong, Damien Rice, Dave Weckl, Desert Island Discs, Dido, drama, entertainment, Errol Brown, fantasy, Hari Haran, Iron Maiden, Jarvis Cocker, Jeff Beck, Kodo, Lee Scratch Perry, male writers, Mel C, music, music for writers, music for writing, musicians, My Memories of a Future Life, Nail Your Novel, Nelly Furtado, Nicko McBrain, outside of this community, percussionist, Pet Shop Boys, Pete Lockett, Peter Gabriel, playlist for writers, Primal Scream, reincarnation, Robert Plant, Ronan Keating, Rory Gallagher, Roz Morris, Sinead O'Connor, Survivor, Texas, The Undercover Soundtrack, The Verve, Thomas Lang, Trans-Global Underground, U Shrinivas, undercover soundtrack, Ustad Zakir Hussain, Vanessa-Mae, writers, writing, writing to music
'The moment of making the first sound or writing the first word is special' – Pete Lockett
Posted by Roz Morris @Roz_Morris in Undercover Soundtrack on April 22, 2014
My guest this week is a percussionist who has worked with an astonishing list of world-class musicians – Bjork, Peter Gabriel, Robert Plant, Dido, Bill Bruford, Jeff Beck, Ustad Zakir Hussain, The Verve, Texas, Trans-Global Underground, Nelly Furtado, Lee Scratch Perry, Primal Scream, Damien Rice, Dave Weckl, Thomas Lang, Jarvis Cocker, Craig Armstrong – and more. He found that his music fuelled a desire to write a novel, and after a good gig he would rush back to his hotel room, eager to pour out the next chapter. He says he wanted to take a simple starting point and construct an epic journey that ventured outside the normal – bringing together birth, death, the afterlife, reincarnation and immortality into new coherence, and echoing the journey he takes when working with musicians. The result is A Survivor's Guide to Eternity; he is Pete Lockett and he'll be here with his Undercover Soundtrack on Wednesday.
A Survivor's Guide to Eternity, authors, Bill Bruford, birth, Bjork, Craig Armstrong, Damien Rice, Dave Weckl, death, Desert Island Discs, Dido, drama, drummer, entertainment, immortality, Jarvis Cocker, Jeff Beck, Lee Scratch Perry, male writers, music, music for writers, music for writing, musicians, My Memories of a Future Life, Nail Your Novel, Nelly Furtado, percussionist, Pete Lockett, Peter Gabriel, playlist for writers, Primal Scream, reincarnation, Robert Plant, Roz Morris, speculative fiction, Survivor, Texas, the afterlife, The Undercover Soundtrack, The Verve, Thomas Lang, Trans-Global Underground, undercover soundtrack, Ustad Zakir Hussain, world-class musicians, writers, writing, writing to music
- The Undercover Soundtrack is a series where writers - and occasionally other arty folk - reveal how music shapes their work.
- It began as a companion to my first novel, My Memories of a Future Life, and now thrives as a creative salon in its own right. Pull on your headphones and join us.
- If you're curious about the novel that started it all, click the image below.
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What is The Undercover Soundtrack?Sleeve notes here
For the soundtrack of My Memories of a Future Life, you'll need Chopin's Sonata in B Minor, Rachmaninov preludes, lashings of Grieg's piano concerto in A minor and The Clash's Rock the Kasbah (they go together well).
You'll also need Samuel Barber's Dover Beach on piano, although that doesn't actually exist so do the best you can.
And the novel's undercover pieces. You can find them here
Previous guests
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Morning Minutes: Dec. 16
Word of the Day
sotto voce \SAH-toh-VOH-chee\ (adverb or adjective) Spoken low or in an undertone, as not to be overheard; (Music) In very soft tones. Used chiefly as a direction. — Dictionary.com
Website of the Day
Distance to Mars
Use this clever site to see how far it really is from Earth to Mars by scrolling through the universe. If the Earth is 100 pixels wide and you're scrolling at 7,000 pixels a second, you'll see how much longer it takes to reach Mars, which is 428,000 pixels away, than the moon, which is a mere 3,000 pixels away.
Number to Know
1672: The first person to ever calculate the distance to Mars was the astronomer Giovanni Cassini, famous for his observations of Saturn, in the year 1672.
This Day in History
Dec. 16, 1944: The Battle of the Bulge begins with the surprise offensive of three German armies through the Ardennes forest.
Today's Featured Birthday
Journalist and "60 Minutes" correspondent Lesley Stahl (72)
Daily Quote
"I don't know of anybody's political bias at CBS News. We try very hard to get any opinion that we have out of our stories, and most of our stories are balanced." — Lesley Stahl


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Anderson Cooper is apparently not a fan of one new high-tech gadget CNN used in its coverage of the Iowa caucuses. He's adding himself to the first 2012 RidicuList.
Post by: Anderson Cooper
Filed under: The RidicuList
Dewey Decimal...does that date us ?
I had to laugh about the "Vic 20" and "Pong" comments....I loved these years.....
Well, it looks hilarious!
Anderson Cooper goes beyond the headlines to tell stories from many points of view, so you can make up your own mind about the news. Tune in weeknights at 8 and 10 ET on CNN.
Questions or comments? Send an email
Want to know more? Go behind the scenes with AC361°