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Renal failure
Renal failure Classification and external resources ICD-10 N17-N19 ICD-9 584-585 DiseasesDB 26060 MeSH C12.777.419.780.500
Renal failure or kidney failure (formerly called renal insufficiency) describes a medical condition in which the kidneys fail to adequately filter toxins and waste products from the blood. The two forms are acute (acute kidney injury) and chronic (chronic kidney disease); a number of other diseases or health problems may cause either form of renal failure to occur.
Renal failure is described as a decrease in glomerular filtration rate. Biochemically, renal failure is typically detected by an elevated serum creatinine level. Problems frequently encountered in kidney malfunction include abnormal fluid levels in the body, deranged acid levels, abnormal levels of potassium, calcium, phosphate, and (in the longer term) anemia as well as delayed healing in broken bones. Depending on the cause, hematuria (blood loss in the urine) and proteinuria (protein loss in the urine) may occur. Long-term kidney problems have significant repercussions on other diseases, such as cardiovascular disease.
- 1 Classification
- 2 Symptoms
- 3 Causes
- 4 Diagnostic approach
- 5 References
- 6 External links
Renal failure can be divided into two categories: acute kidney injury or chronic kidney disease. The type of renal failure is determined by the trend in the serum creatinine. Other factors which may help differentiate acute kidney injury from chronic kidney disease include anemia and the kidney size on ultrasound. Chronic kidney disease generally leads to anemia and small kidney size.
Acute kidney injuryMain article: Acute kidney injury
Acute kidney injury (AKI), previously called acute renal failure (ARF), is a rapidly progressive loss of renal function, generally characterized by oliguria (decreased urine production, quantified as less than 400 mL per day in adults,[1] less than 0.5 mL/kg/h in children or less than 1 mL/kg/h in infants); and fluid and electrolyte imbalance. AKI can result from a variety of causes, generally classified as prerenal, intrinsic, and postrenal. An underlying cause must be identified and treated to arrest the progress, and dialysis may be necessary to bridge the time gap required for treating these fundamental causes.
Chronic kidney diseaseMain article: Chronic kidney disease
Chronic kidney disease (CKD) can develop slowly and, initially, show few symptoms. CKD can be the long term consequence of irreversible acute disease or part of a disease progression.
Acute-on-chronic renal failure
Acute kidney injuries can be present on top of chronic kidney disease, a condition called acute-on-chronic renal failure (AoCRF). The acute part of AoCRF may be reversible, and the goal of treatment, as with AKI, is to return the patient to baseline renal function, typically measured by serum creatinine. Like AKI, AoCRF can be difficult to distinguish from chronic kidney disease if the patient has not been monitored by a physician and no baseline (i.e., past) blood work is available for comparison.
Symptoms can vary from person to person. Someone in early stage kidney disease may not feel sick or notice symptoms as they occur. When kidneys fail to filter properly, waste accumulates in the blood and the body, a condition called azotemia. Very low levels of azotaemia may produce few, if any, symptoms. If the disease progresses, symptoms become noticeable (if the failure is of sufficient degree to cause symptoms). Renal failure accompanied by noticeable symptoms is termed uraemia.[2]
Symptoms of kidney failure include:[2][3][4][5]
- High levels of urea in the blood, which can result in:
- Vomiting and/or diarrhea, which may lead to dehydration
- Nausea
- Weight loss
- Nocturnal urination
- More frequent urination, or in greater amounts than usual, with pale urine
- Less frequent urination, or in smaller amounts than usual, with dark coloured urine
- Blood in the urine
- Pressure, or difficulty urinating
- Unusual amounts of urination, usually in large quantities
- A build up of phosphates in the blood that diseased kidneys cannot filter out may cause:
- Itching
- Bone damage
- Nonunion in broken bones
- Muscle cramps (caused by low levels of calcium which can cause hypocalcaemia)
- A build up of potassium in the blood that diseased kidneys cannot filter out (called hyperkalemia) may cause:
- Abnormal heart rhythms
- Muscle paralysis[6]
- Failure of kidneys to remove excess fluid may cause:
- Swelling of the legs, ankles, feet, face and/or hands
- Shortness of breath due to extra fluid on the lungs (may also be caused by anemia)
- Polycystic kidney disease, which causes large, fluid-filled cysts on the kidneys and sometimes the liver, can cause:
- Pain in the back or side
- Healthy kidneys produce the hormone erythropoietin which stimulates the bone marrow to make oxygen-carrying red blood cells. As the kidneys fail, they produce less erythropoietin, resulting in decreased production of red blood cells to replace the natural breakdown of old red blood cells. As a result, the blood carries less hemoglobin, a condition known as anemia. This can result in:
- Feeling tired and/or weak
- Memory problems
- Difficulty concentrating
- Dizziness
- Low blood pressure
- Proteins are usually too big to pass through the kidneys, but they can pass through when the glomeruli are damaged. This does not cause symptoms until extensive kidney damage has occurred,[7] after which symptoms include:
- Foamy or bubbly urine
- Swelling in the hands, feet, abdomen, or face
- Other symptoms include:
- Appetite loss, a bad taste in the mouth
- Difficulty sleeping
- Darkening of the skin
- Excess protein in the blood
Acute renal failure
Acute kidney failure usually occurs when the blood supply to the kidneys is suddenly interrupted or when the kidneys become overloaded with toxins. Causes of acute failure include accidents, injuries, or complications from surgeries in which the kidneys are deprived of normal blood flow for extended periods of time. Heart-bypass surgery is an example of one such procedure.
Drug overdoses, accidental or from chemical overloads of drugs such as antibiotics or chemotherapeutics, may also cause the onset of acute kidney failure. Unlike in chronic kidney disease, however, the kidneys can often recover from acute failure, allowing the patient to resume a normal life. People suffering from acute failure require supportive treatment until their kidneys recover function, and they often remain at increased risk of developing future kidney failure.[8]
Among the accidental causes of renal failure is there also the crush syndrome, when large amounts of toxins are suddenly released in the blood circulation after a long compressed limb is suddenly relieved from the pressure obstructing the blood flow through its tissues, causing ischemia. The resulting overload can lead to the clogging and the destruction of the kidneys. It is a reperfusion injury that appears after the release of the crushing pressure. The mechanism is believed to be the release into the bloodstream of muscle breakdown products – notably myoglobin, potassium and phosphorus – that are the products of rhabdomyolysis (the breakdown of skeletal muscle damaged by ischemic conditions). The specific action on the kidneys is not fully understood, but may be due in part to nephrotoxic metabolites of myoglobin.
Chronic kidney disease
CKD has numerous causes. The most common is diabetes mellitus. The second most common is long-standing, uncontrolled, hypertension, or high blood pressure. Polycystic kidney disease is another well-known cause of CKD. The majority of people afflicted with polycystic kidney disease have a family history of the disease. Other genetic illnesses affect kidney function as well.
Overuse of common drugs such as aspirin, ibuprofen, and acetaminophen (paracetamol) can also cause chronic kidney damage.[9]
Some infectious diseases such as hantavirus can attack the kidneys, causing kidney failure.
Genetic predisposition
The APOL1 gene has been proposed as a major genetic risk locus for a spectrum of nondiabetic renal failure in individuals of African origin, these include HIV-associated nephropathy (HIVAN), primary nonmonogenic forms of focal segmental glomerulosclerosis, and hypertension affiliated chronic kidney disease not attributed to other etiologies.[10] Two western African variants in APOL1 have been shown to be associated with end stage kidney disease in African Americans and Hispanic Americans.[11][12]
Diagnostic approach
Measurement for CKD
- Stages of kidney failure
Chronic kidney failure is measured in five stages, which are calculated using a patient's GFR, or glomerular filtration rate. Stage 1 CKD is mildly diminished renal function, with few overt symptoms. Stages 2 and 3 need increasing levels of supportive care from their medical providers to slow and treat their renal dysfunction. Patients in stages 4 and 5 usually require preparation of the patient towards active treatment in order to survive.Stage 5 CKD is considered a severe illness and requires some form of renal replacement therapy (dialysis) or kidney transplant whenever feasible.
- Glomerular filtration rate
A normal GFR varies according to many factors, including sex, age, body size and ethnicity. Renal professionals consider the glomerular filtration rate (GFR) to be the best overall index of kidney function.[13] The National Kidney Foundation offers an easy to use on-line GFR calculator[14] for anyone who is interested in knowing their glomerular filtration rate. (A serum creatinine level, a simple blood test, is needed to use the calculator).
Use of the term uremia
Before the advancement of modern medicine, renal failure was often referred to as uremic poisoning. Uremia was the term used to describe the contamination of the blood with urine. Starting around 1847, this term was used to describe reduced urine output, that was thought to be caused by the urine mixing with the blood instead of being voided through the urethra.[citation needed] The term uremia is now used to loosely describe the illness accompanying kidney failure.[15]
- ^ Klahr S, Miller S (1998). "Acute oliguria". N Engl J Med 338 (10): 671–5. doi:10.1056/NEJM199803053381007. PMID 9486997. http://content.nejm.org/cgi/content/full/338/10/671.
- ^ a b Dr Per Grinsted (2005-03-02). "Kidney failure (renal failure with uremia, or azotaemia)". http://www.netdoctor.co.uk/diseases/facts/kidneyfailure.htm. Retrieved 2009-05-26.
- ^ Dr Andy Stein (2007-07-01). Understanding Treatment Options For Renal Therapy. Deerfield, Illinois: Baxter International Inc.. p. 6. ISBN 1859590705. http://www.renalinfo.com.
- ^ The PD Companion. Deerfield, Illinois: Baxter International Inc.. 2008-05-01. pp. 14–15. 08/1046R. http://www.renalinfo.com/uk.
- ^ Amgen Inc. (2009). "10 Symptoms of Kidney Disease". http://www.lifeoptions.org/kidneyinfo/ckdinfo.php?page=4. Retrieved 2009-05-26.
- ^ MedicineNet, Inc. (2008-07-03). "Hyperkalemia". http://www.medicinenet.com/hyperkalemia/page4.htm. Retrieved 2009-05-26.
- ^ Lee A. Hebert, M.D., Jeanne Charleston, R.N. and Edgar Miller, M.D. (2009). "Proteinuria". http://kidney.niddk.nih.gov/kudiseases/pubs/proteinuria/. Retrieved 2011-03-24.
- ^ Your Kidneys and How They Work- How do kidneys fail? National Kidney and Urologic Diseases Information Clearing House. NIDDK. NIH Publication No. 07–3195.August 2007. * Publications produced by the Clearinghouse are carefully reviewed by both NIDDK scientists and outside experts. http://kidney.niddk.nih.gov/Kudiseases/pubs/yourkidneys/#7.
- ^ Perneger TV, Whelton PK, Klag MJ (December 1994). "Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs". N. Engl. J. Med. 331 (25): 1675–9. doi:10.1056/NEJM199412223312502. PMID 7969358. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=7969358&promo=ONFLNS19.
- ^ Bostrom MA, Freedman BI. (2010). "The spectrum of MYH9-associated nephropathy.". Clin J Am Soc Nephrol 5 (6): 1107–13. doi:10.2215/CJN.08721209. PMID 20299374.
- ^ Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR. (Jul 2010). "Association of Trypanolytic ApoL1 Variants with Kidney Disease in African-Americans". Science 329 (5993): 841–5. doi:10.1126/science.1193032. PMC 2980843. PMID 20647424. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2980843.
- ^ Tzur S, Rosset S, Shemer R, Yudkovsky G, Selig S, Tarekegn A, Bekele E, Bradman N, Wasser WG, Behar DM, Skorecki K. (Jul 2010). "Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.". Human Genetics 128 (3): 345–50. doi:10.1007/s00439-010-0861-0. PMC 2921485. PMID 20635188. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2921485.
- ^ Fadem, Stephen Z., M.D., FACP, FASN. Calculators for HealthCare Professionals. National Kidney Foundation. 13 Oct 2008
- ^ "GFR calculator". Kidney.org. http://www.kidney.org/professionals/KDOQI/gfr_calculator.cfm. Retrieved 2011-09-25.
- ^ Meyer TW and Hostetter, TH (2007). "Uremia". N Engl J Med 357 (13): 1316. doi:10.1056/NEJMra071313. PMID 17898101. http://content.nejm.org/cgi/content/full/357/13/1316.
External links
- Connecting dialysis community around the World (US)
- National Kidney Foundation (US)
- The Kidney Foundation of Canada(CA)
Urinary system · Pathology · Urologic disease / Uropathy (N00–N39, 580–599) AbdominalGlomerulopathy/
nephrotic.0 Minimal change · .1 Focal segmental · .2 Membranous.3 Mesangial proliferative · .4 Endocapillary proliferative .5/.6 Membranoproliferative/mesangiocapillaryBy conditionPost-streptococcal · Lupus (DPN) · IgA/Berger'sType III RPG/Pauci-immuneTubulopathy/
tubulitisRTA (RTA 2) · Fanconi syndromeAny/allAny/allGeneral syndromesRenal failure (Acute renal failure, Chronic renal failure) · Uremic pericarditis · UremiaOtherUreter
PelvicUrethraUrethritis (Non-gonococcal urethritis) · Urethral syndrome · Urethral stricture/Meatal stenosis · Urethral caruncle Any/allObstructive uropathy · Urinary tract infection · Retroperitoneal fibrosis · Urolithiasis (Bladder stone, Kidney stone, Renal colic) · Malacoplakia · Urinary incontinence (Stress, Urge, Overflow) Organ failure GeneralHeart failure · Respiratory failure · Liver failure (Acute liver failure) · Renal failure (Acute renal failure, Chronic renal failure ) MultipleCategories:
Wikimedia Foundation. 2010.
Look at other dictionaries:
renal failure — A condition in which the kidneys stop working and are not able to remove waste and extra water from the blood or keep body chemicals in balance. Acute or severe renal failure happens suddenly (for example, after an injury) and may be treated and… … English dictionary of cancer terms
renal failure — noun inability of the kidneys to excrete wastes and to help maintain the electrolyte balance • Syn: ↑kidney failure • Hypernyms: ↑kidney disease, ↑renal disorder, ↑nephropathy, ↑nephrosis, ↑failure … Useful english dictionary
renal failure — the inability of a kidney to excrete metabolites at normal plasma levels under conditions of normal loading, or the inability to retain electrolytes under conditions of normal intake, so that waste products and metabolites accumulate in the blood … Medical dictionary
renal failure — kidney failure, lack of kidney function … English contemporary dictionary
renal failure index — (RFI) an assessment of acute renal failure comparing the sodium clearance with the creatinine clearance: where PCr = plasma concentration of creatinine, UCr = urinary concentration of creatinine, and UNa = urinary concentration of sodium. A value … Medical dictionary
Acute renal failure — (ARF), also known as acute kidney failure or acute kidney injury, is a rapid loss of renal function due to damage to the kidneys, resulting in retention of nitrogenous (urea and creatinine) and non nitrogenous waste products that are normally… … Wikipedia
acute renal failure — noun renal failure associated with burns or other trauma or with acute infection or obstruction of the urinary tract • Syn: ↑acute kidney failure • Hypernyms: ↑renal failure, ↑kidney failure … Useful english dictionary
chronic renal failure — noun renal failure that can result from a variety of systemic disorders • Syn: ↑chronic kidney failure • Hypernyms: ↑renal failure, ↑kidney failure … Useful english dictionary
acute renal failure — (ARF) renal failure of sudden onset, such as from physical trauma, infection, inflammation, or toxicity; symptoms include uremia and usually oliguria or anuria, with hyperkalemia and pulmonary edema. Three types are distinguished: prerenal,… … Medical dictionary
end-stage renal failure — the most advanced stage of kidney failure, which is reached when the glomerular filtration rate (GFR) falls to 5 ml/min (normal GFR = 120 ml/min) … Medical dictionary


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Video trailer
Rachel Hopkins
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Original titleMatriarch
IMDb Rating5.4 2,804 votes
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Rating: 2.5/5
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Wow, is this some minimalistic music or what? It certainly fits the theme of emptiness and monotony. Is it fun to listen to, though? It's fine for a while as the ideas that are used are pretty good, but many will lose interest after the two-minute mark or so. After that, only the hardcore will be left listening; perhaps the catatonic, who have lives just as painfully dull (it could be interpreted) as Kenosis's material and consequently who don't care about having a good time. A lot of Burzum's music is highly minimal, but with that one man band, at least the musician knows when enough is enough and when to change themes. Again, with Consecrationem, your endurance will be tested.
Other than in terms of structure, however, this is pretty standard BM. It's consistently evil, filled with blast beats, tremolo picking and screams. The kind you may have heard literally hundreds of times before. In particular, it's quite like Gorgoroth in mood and in fact Kenosis's track 'With Open Veins' has a riff in it rather similar to Gorg's 'White Seed'. In the band's defence, at least their two guitarists often play independent lines. They keep the listener's attention for at least a little while.
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Schools of Psychology Term Paper by ResearchRiter
Schools of Psychology
An overview of the major schools of psychology.
# 124255 | 750 words | 7 sources | MLA | 2008 |
Published on Dec 01, 2008 in Psychology (Theory)
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A brief overview of the various major schools of psychology such as psychoanalysis, behaviorism, cognitivism and humanism. The paper discusses the role of biology in shaping development.
From the Paper:"The major schools or theories of psychology include the psychodynamic school, the behavioral school, the cognitive school and what is variously called the humanist or evolutionary school. Underpinning much in psychology are its biological foundations. Corey pointed out that most theories of human psychology acknowledge the existence of genetic factors in shaping behavior, personality and attitudes. Similarly, Corey commented that biological developmental trajectories, though hardly consistent across groups and individuals, play a vital role in fostering the capacity of the individual to..."
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Welcome to the Zlatko Ćosić: Still Adjusting online exhibition. Gallery 210 originally presented this exhibition from January 25 to March 22, 2014. The artist has graciously put together a virtual exhibition of his exhibition for the Gallery 210 homepage.
The works in the exhibition, featuring seven experimental and non-fiction short films videos and an installation, are inspired by the artist's experience of dislocation resulting from 1990s conflicts in the former Yugoslavia.
Addressing the themes of dislocation, identity, immigration, culture shock and assimilation Ćosić states, I feel as if I am part of a performance, caught between my past and the present. I adjust how I communicate with the people who are not from my culture. At the same time, this other society has altered the way I communicate with people from my country. (excerpt from the exhibition essay What's in a Name by Dana Turkovic). Please click on the catalog button on the exhibition window to read the full essay.
Zlatko Ćosić is a video artist born in Banja Luka, Yugoslavia (present day Bosnia and Herzegovina). Ćosić's artwork includes short films, video installations, and live audio-visual performances. His work relates to issues of identity, immigration, and the complexities of living in unfamiliar cultural environments. Ćosić's artwork has been shown in over fifty countries, for which he has received a variety of recognition and he continues to create new work. To see more of Zlatko Ćosić's work visit his website at www.zlatkocosic.com.
This exhibition was supported by grants from the Regional Arts Commission and the Missouri Arts Council with additional assistance from the Center for the Humanities at UM-St. Louis.


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A cross section of residents of Ekwulumili in the Nnewi South Local Government Area of Anambra State, are of the view that the six siblings, who died after eating the rice and beans their mother cooked were poisoned.
Read also: 25 YRS OLD MAN KILLS MOTHER, TWO SIBLINGS, DUMPS BODIES IN DAM
Their bereaved parents had attempted suicide just as rumour rife that the family was involved in a land tussle and opposition masterminded the poisoning of the food in their kitchen.
But police have rejected the claims insisting they were not poisoned.
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"The six children died after eating their mother's food," the Commissioner of Police in Anambra State, Mr. Hosea Karma told Punch.


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© Benjamin Orion rush, Kelvin, from the series Field Notes: Statements & Sketches
© Benjamin Orion rush, Kelvingrove Hall, from the series Field Notes: Statements & Sketches
"New England-born artist Benjamin Rush presents selections from two new ongoing bodies of work in "Field Notes: Statements & Sketches". Central to the exhibition are images created in museums, libraries, and galleries both in the US and overseas. With a large format camera he seeks out surreal compositions of not only the display of these institutions, but also of these authoritative spaces in states of undress and change. The images stem from Rush's fascination with the idea of knowledge, and the governance that possesses, frames and presents it.
The "Sketches" portion of the exhibition appear as selections from a body of 170-and-counting images that Rush has taken with a 1960's Polaroid Land Camera. Rush says: "My life these past few years has been very unsettled and hectic, this more casual approach to image-making keeps me considering my environment. I'm always fascinated by how things look as photographs. I was curious how my interests and aesthetic might become evident without any particular intent across a large group of images taken over many years."
These images describe Rush's connection to the art and history of photography on many levels. "Frankly, I sometimes wonder if I'm just addicted to the way this particular process smells and behaves, " he says. "Obviously it's almost immediate but, unlike digital, when you peel the print open – the print is wet and fragile for some time, it's a very tactile experience"."
Source: Dakota Ridge Gallery
To see more of Benjamin's work click here


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Smartphone manufacturer Asus recently announced the launch date of its latest series of ZenFone 7 phones. Now the company has posted a teaser video related to this series on its official Twitter account, where the design of the upcoming Zenfone 7 smartphone can be seen. Apart from this, a camera is mentioned. The flagship smartphone is also in this video. Let us tell you that before the teaser of the Zenfone 7 was released, several reports related to it were leaked, which provided information about its price and potential feature.
Asus Deutschland has released a teaser video on its official Twitter account, where the upcoming ZenFone 7 can be seen. In the video, the Zenfone 7 features thin bezels. Apart from this, the phrase "Flip Deine Welt" is used in this video. In Hindi, this phrase means 'the heart of your world'. With this said, there is speculation that the Zenfone 7 will hit the market with its face camera.
Expected specifications for the Asus Zenfone 7 series
According to media reports that have surfaced, Asus can introduce a Snapdragon 865 Plus processor with a high-resolution display in the upcoming Zenfone 7 and Zenfone 7 Pro smartphones. Apart from that, 16GB of RAM and Android 10 could be supported in each of these upcoming smartphones. Aside from this, Zenfone 7 and Zenfone 7 Pro are both expected to have rear cameras like Zenfone 6. However, other features of both smartphones have yet to be reported.
The expected price for Asus Zenfone 7 series
According to the leaked report, Asus Zenfone 7 and Zenfone 7 Pro can be priced between 60,000 and 70,000 rupees. At the same time, this smartphone will pose a tough challenge for the devices of companies like Apple and Samsung.
Asus Zenfone 6 smartphone
Let us tell you that the company launched the Asus Zenfone 6 smartphone last year. Speaking of features, this phone has a 6.4-inch FHD + display. Besides, Qualcomm's Snapdragon 855 processor will be available in the phone, 640 GPU for graphics, and up to 256 GB of storage with 8 GB of RAM. Apart from this, this phone has a dual-camera setup which is rotary-style i.e. the camera can be easily rotated back and forth. It contains a 48-megapixel camera, with an f / 1.79 lens slot, and a 13-megapixel wide-angle camera. A dual-LED flash will be included with the camera.


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Cannabidiol as a Treatment for AUD Comorbid With PTSD
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT03248167
Recruitment Status : Recruiting
First Posted : August 14, 2017
Last Update Posted : November 13, 2020
NYU Langone Health
National Institutes of Health (NIH)
Information provided by (Responsible Party):
NYU Langone Health
|Tracking Information
|First Submitted Date ICMJE
|August 2, 2017
|First Posted Date ICMJE
|August 14, 2017
|Last Update Posted Date
|November 13, 2020
|Actual Study Start Date ICMJE
|September 16, 2019
|Estimated Primary Completion Date
|August 31, 2021 (Final data collection date for primary outcome measure)
|Current Primary Outcome Measures ICMJE
|Number of drinks per day [ Time Frame: Baseline to 6 Weeks ]
Number of drinks per day will be assessed with the Time Line Follow Back scale.
|Original Primary Outcome Measures ICMJE
|Same as current
|Change History
|Current Secondary Outcome Measures ICMJE
|Original Secondary Outcome Measures ICMJE
|Current Other Pre-specified Outcome Measures
|Not Provided
|Original Other Pre-specified Outcome Measures
|Not Provided
|Descriptive Information
|Brief Title ICMJE
|Cannabidiol as a Treatment for AUD Comorbid With PTSD
|Official Title ICMJE
|Cannabidiol as a Treatment for Alcohol Use Disorder Comorbid With Posttraumatic Stress Disorder
|Brief Summary
|This project aims to determine whether cannabidiol (CBD), a compound derived from the cannabis plant, is effective in treating alcohol use disorder (AUD) in individuals with comorbid posttraumatic stress disorder (PTSD). Investigators will test the hypothesis that oral cannabidiol (CBD) will reduce alcohol drinking in individuals with AUD comorbid with PTSD. To test this hypothesis, 48 otherwise healthy adult participants with moderate or severe AUD and PTSD will be randomized to treatment with either CBD (600 mg daily) or placebo, for a period of 6 weeks, such that both participants and study staff are blind to treatment condition. Participants (each treated for 6 weeks) will be continuously recruited over a study period of 14 months until 48 have completed. Baseline and weekly data will be collected on alcohol usage and PTSD symptoms, and investigators will assess whether CBD treatment leads to a greater improvement in these measures relative to placebo, and whether reduction in alcohol drinking is temporally linked to improvement in PTSD symptoms. Subjects will also participate in a task designed to quantify the psychological and physiological links between negative emotion produced by re-experiencing PTSD trauma, and alcohol craving. The task will be administered following 4 weeks of treatment. Treatment-associated reduction in alcohol craving elicited by trauma-associated negative emotion between CBD and placebo groups will be compared. This study will be the first to test whether CBD is effective in treating alcohol addiction and in treating PTSD in humans, and the first to examine the interaction between these treatment effects. Results will serve as proof of concept and provide guidance for a future larger clinical trial. Because CBD is a safe, readily available drug, such a trial would have an immense potential to prevent death, medical illness, and psychological suffering associated with AUD and PTSD. Further, because the brain circuits via which CBD acts to produce hypothesized effects are relatively well-understood, results may substantially advance understanding of the neurobiological basis of alcohol addiction.
|Detailed Description
|In this project, investigators aim to test the hypothesis that CBD will reduce alcohol drinking in individuals with AUD comorbid with PTSD. CBD is currently a medical research focus because it shows promise for treating anxiety and other brain disorders, but does not produce a 'high' like other parts of cannabis, has not been shown to be addictive, and is safe, with few or no side effects. AUD, which is one of the most common and most debilitating psychiatric conditions, is often associated with other comorbid psychiatric disorders - in particular, PTSD: depending on the population studied, 30-60% of individuals with AUD also have PTSD, with high comorbidity rates in military veterans. Evidence from animal models and clinical studies suggests that the negative emotion caused by PTSD symptoms intensifies craving for alcohol during alcohol withdrawal, perpetuating the addictive cycle; further, evidence shows that the brain circuits underlying negative emotion and addiction are linked in a forebrain area called the extended amygdala, which provides a neuropharmacological target to simultaneously treat both negative emotion and alcohol addiction in individuals with AUD and PTSD. CBD is known to inhibit brain activity in the extended amygdala, leading to reduced anxiety in both animal models and humans. CBD also reduces addictive alcohol seeking in animal models.
|Study Type ICMJE
|Study Phase ICMJE
|Phase 1
Phase 2
|Study Design ICMJE
|Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
|Condition ICMJE
|Intervention ICMJE
|Study Arms ICMJE
|Publications *
|Not Provided
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Information
|Recruitment Status ICMJE
|Estimated Enrollment ICMJE
|Original Estimated Enrollment ICMJE
|Estimated Study Completion Date ICMJE
|August 31, 2021
|Estimated Primary Completion Date
|August 31, 2021 (Final data collection date for primary outcome measure)
|Eligibility Criteria ICMJE
Inclusion Criteria:
Exclusion Criteria:
|Sex/Gender ICMJE
|Ages ICMJE
|18 Years to 70 Years (Adult, Older Adult)
|Accepts Healthy Volunteers ICMJE
|Contacts ICMJE
|Listed Location Countries ICMJE
|United States
|Removed Location Countries
|Administrative Information
|NCT Number ICMJE
|Other Study ID Numbers ICMJE
|Has Data Monitoring Committee
|U.S. FDA-regulated Product
|IPD Sharing Statement ICMJE
|Responsible Party
|NYU Langone Health
|Study Sponsor ICMJE
|NYU Langone Health
|Collaborators ICMJE
|National Institutes of Health (NIH)
|Investigators ICMJE
|PRS Account
|NYU Langone Health
|Verification Date
|November 2020
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP


text:
Definitely more in attendance than last night for the iPPV. I suspect more casual fans looking for something to do on a Saturday night. Lively crowd that started to quiet down after Strong vs. Nakamura, but they picked up again for the last match.
Episode 1:
Match 1: KUSHIDA beat Will Ferrara in a fast-paced match. Ferrara got his fair share of offense. The Toronto crowd loves KUSHIDA. KUSHIDA gets the win after a Keylock.
After the match, The Addiction come to ringside to challenge reDRagon next week
Match 2: Silas Young pins Watanabe after a TKO. Good back and forth match. Crowd love for Watanabe seems outsized to his accomplishments, but they loved everyone from New Japan. Lots of heat for Silas.
The Decade come to the ring followed by BJ Whitmer's scheduled opponent, Moose (with Veda Scott and Stokely Hathaway). BJ insists that the Decade's new young boy, Colby Corino, "step up" and take his spot against Moose.
Match 3: Moose squashed Colby Corino in a short match. Colby took a BEATING tonight, including being thrown into the ringside barriers, and being swung back and forth into them, giant swing-style . Veda Scott gave him a great slap on the outside too. BJ spends most of the match gleefully watching Steve Corino's reaction from the commentary table. Moose wins after a spear; Veda is happy, Stokely looks remorseful before leaving. Adam Page and BJ help Colby leave the ring, before sending him back to retrieve the water bucket. BJ had the most heel heat of the evening by far.
Match 4: The Briscoes beat Donovan Dijak and J. Diesel of The House of Truth in a good tag match. No interference by Truth Martini who made it into Canada after being absent last night, or from Jay Lethal on commentary. The Briscoes got a far more positive reaction against ROH opponents than they had against the Bullet Club last night. Briscoes win after hitting the Doomsday Device on J. Diesel. After the match, Dijak pulls Mark from the ring and hits his finisher, a torture rack flipped over into a Go 2 Sleep, before being taken out with a dive from Jay Briscoe. Back in the ring, Jay Lethal tries to jump Briscoe from behind before being laid out with the Jay Driller.
Episode 2:
The Addiction come to the ring to inform the crowd that Bobby Fish is being held off the show due to injury, however their rematch challenge was to reDRagon, not to "Kyle O'Reilly and a suitable replacement". They say that if reDRagon doesn't come for their rematch now, there will be no rematch. Kyle O'Reilly comes to the ring to challenge The Addiction two on one.
Match 1: Kyle O'Reilly beats The Addiction by DQ. O'reilly holds his own in the handicap match for as long he can, eventually trapping Kazarian in an armbar. Christopher Daniels with a blatant belt shot to the head in front of the ref causes the DQ, followed by Daniels laying out the ref. ACH and Matt Sydal make the save and run-off Daniels and Kazarian.
Match 2: Jushin Thunder Liger defeats Dalton Castle in a better match than one might have guessed. What could have been just a comedy match was much more, and worth going out your way to check out. Sign that it's 2015: crowds everywhere love Dalton Castle unironically, and Toronto is no exception. During the match, Liger invites Castle's attendants into the ring to pose with him. Liger wins with a brainbuster.
Match 3: "Brutal" Bob Evans vs Cheeseburger ends in a no contest after Bob sidewalk slams Cheeseburger from the apron through the timekeeper's table. The crowd had died down early into this short match, as enthusiasm for Cheeseburger seems to wane once his entrance ends and a match that's meant to be believable starts. The table spot surprised everyone, and a "rest in peace" chant briefly started.
Match 4: The Kingdom (Matt Taven & Mike Bennett) vs The Bullet Club (Luke Gallows and Karl "Machine Gun" Anderson ended in a No Contest or double DQ after both Bennett and Anderson each and then together shoved down the referee. Anderson chased Maria around the ring to start the match, which had some good moments, but was just getting into second gear when it ended. A highlight was Anderson countering an attempted double-team move to Gallows on the outside by The Kingdom into a Gun Stun (RKO) "out of nowhere" on an airborne Taven. After the match, Maria saved Bennett from a Magic Killer (elevated twisting neckbreaker slam) onto 2 upright chairs, only to almost fall victim herself, Bennett helps Maria escape, but Taven is not so lucky and receives the Magic Killer onto the chairs. Bullet Clubs raises the IWGP Tag titles before leaving.
Episode 3:
The Decade come to the ring followed by their scheduled opponents, War Machine. In a move reminiscent of the Moose match, BJ insists that Colby Corino "step up" and take his spot as Adam Page's tag team partner against War Machine.
Match 1: War Machine defeats The Decade in a short match, more an angle again, really, to further the BJ Whitmer / Steve Corino feud that seems to be building up. A reluctant Ray Rowe tags in Hanson after an insistent Colby presses the matter with a slap to the face. War Machine squash Colby with power moves until Adam Page drops off the apron after refusing to tag-in. War Machine finish Colby off with their finisher (a back suplex by Rowe/ top rope leg drop by Hanson combo) to end the carnage. Whitmer again spends the match watching and taunting Steve Corino. Corino gets up to challenge Whitmer after the pinfall, but is restrained despite taunts by The Decade. Page paintbrushes Colby in the ring before The Decade again helps him leave, and again sends him back to retrieve the water bucket and stagger out.
Cedric Alexander comes to the ring and announces that it's "do or die time" after a less than successful past year, and he's starting by challenging the undefeated Moose.
Match 2: Cedric Alexander defeats Moose (with Veda Scott and Stokely Hathaway). I should note here that Moose is super over. Cedric begins to win back the crowd and even up the match against a dominant Moose with high spots and dives. Cedric takes it to Moose with a series of brutal running dropkicks to Moose in the corner before eating a spear. While both men are down and receiving a 10-count, Veda slips Moose a wrench from under the ring. While Stokely Hathaway distracts the ref, Moose refuses to use the wrench and argues with Veda; the distraction allows Cedric to take the wrench from Moose and nail him with it. Cedric Alexander has seemingly turned to the dark side and ended Moose's streak! Veda escapes up the entrance way and Stokely is left stunned in the ring with Moose.
Match 3: Hiroshi Tanahashi and Tetsuya Naito defeat ACH and Matt Sydal in a competitive match. This was one of the few instances where the ROH talent had even 50/50 support from the crowd against the New Japan talent. Lots of offense from ACH in this. Some brief heelish moments from the New Japan babyfaces. Worth checking out but too much action to call; Tanahashi wins with the High Fly Flow frog splash on ACH while Naito grappled with Sydal to prevent him from running in for the save.
The episode ends with Nigel McGuinness a contract signing for the Title vs Title match between Jay Briscoe and Jay Lethal. A couple funny moments to note from the crowd: with the obvious situation about to unfold, what with Nigel in front of a table in the ring with a clipboard a "Con-tract sign-ing (clap, clap, clap-clap-clap)" chant broke out, followed a few minutes later with "Sign Up (clap-clap) for Jay instead of the usual "Man Up" when it was his turn to put pen to paper. The normal war of words, but no physical action. Briscoe catches a possible attempt at a belt shot from Lethal and stares him down. Probably better than I've made it sound.
Episode 4:
The pace picked up for this last episode with 2 long matches, 1 short one and no talking segments.
Match 1: Shinsuke Nakamura defeats Roderick Strong in a hard hitting, competitive match. Words won't do this justice. The crowd loved Strong, but they loved Nakamura more than almost anyone. I'm not one for star ratings but this is a match to seek out at all costs. Nakamura wins with the Boma Ye knee strike after a number of close calls from Roddy. Cannot undersell how good this was.
Match 2: Michael Elgin defeats Gedo in a short match. Not a squash but seemingly designed to highlight Elgin, and maybe to put another win in the ROH column. Elgin wins with the buckle bomb followed by the spinning sit-out powerbomb.
Match 3: The Bullet Club (AJ Styles and The Young Bucks, with Gallows and Anderson) defeat CHAOS ("The Rainmaker" Kazuchika Okada and Roppongi Vice (Rocky Romero and Trent Baretta)). Again, words, won't do this justice. Crowd was hot for every member of both teams, giving each their own chant as they individually posed on the turnbuckles, before cheering NJPW ref "Red Shoes" to pose as well. This match was Indy wrestling insanity at its finest, in the vein of last nights main event or the last time Styles and the Young Bucks teamed on ROH TV. A glorious spotfest that Jim Cornette or Les Thatcher would hate. I'm not overly partial to this type of match sometimes myself, but if you don't enjoy this, you hate fun. The finish was an assisted spike ganso bomb piledriver (I think Styles has been calling it the Hollowpoint) by Styles to Baretta who was then passed to Matt Jackson for the Meltzer Driver springboard somersault spike tombstone; Baretta was then passed back to Styles to receive a double superkick from the Bucks as AJ hit the Styles Clash. Just that sentence was exhausting, imagine how Trent Baretta felt.
After the match, Okada approached Styles for a handshake but was attacked by the entire Bullet Club, with Romero unsuccessful with the save until The Kingdom, minus Adam Cole, ran out to even the odds. The Bullet Club were beaten back and Okada laid Styles out with the Rainmaker clothesline. Okada retrieved the IWGP title before dropping onto Styles and placing a boot on his chest and hitting the Rainmaker pose. The new allies of CHAOS and The Kingdom celebrate as the show ends.
Possibly off-air, Rocky Romero and Okada compete at playing to the crowd with the Rainmaker pose from the turnbuckles; the competition grows heated and the two have words before embracing.
If you enjoy PWInsider.com you can check out the AD-FREE PWInsider Elite section, which features exclusive audio updates, news, our critically acclaimed podcasts, interviews and more by clicking here!
Use our reports with online gambling where you can play casino games or bet on different kind of sports!


text:
Man Designs Burial Posters For his Wife's Lover
Man Designs Burial Posters For his Wife's Lover
Social media has being awashed with posters a Nigerian man designed for a young man sleeping with his wife.
The disgruntled husband (name withheld) warned the young man identified as Tunde, to stay away from his wife or die on top of her. He went further to reveal Tunde's contact details in the viral posters
The poster reads, "Mr Papilo Tunde a native of Ondo State, stop sleeping with my wife. You will die on top of her ooo!
Guys please leave married women alone, same goes to married women, biko concentrate on your family…


text:
Companies give video interview and training in Pudong
With spring almost here, job hunting and recruitment activities are becoming increasingly frequent. Video interviews have become a popular way for many companies in Pudong New Area to recruit new workers due to the outbreak of the novel coronavirus, while previously the system was only used by large internet companies for job applicants who lived far away.
CloudWalk, a local facial recognition technology company, recently posted many sales job vacancies in fields such as education, finance, security, and transportation, and said they will give video interviews to avoid face-to-face contact.
According to a survey by Zhaopin, an online job recruitment platform, during the epidemic control period, 68.2 percent of companies said they would like the platform to offer matchmaking services to help them find the most suitable resumes, and 55 percent of companies said they would like the platform to offer video interview services.
"We posted our recruitment notice on various platforms and received more than 1,000 replies every day," said an HR worker at the company, adding that they have already recruited several workers through video interview.
In addition, companies have also been training new employees online. Among them is iTutorGroup, a local online education platform.
The company posted two jobs, Course Consultant and Teaching Assistant, and allowed job applicants to interview, receive job training and complete employment procedures online at home. Employees can also choose to work from home after they sign the contract.
A trainer at the company can give lectures to employees all over the country simultaneously through 36 electronic screens.
"Hit by the epidemic, many offline service companies have to shut down. As one of the biggest online education companies in China, we hope to take advantage of the internet and help people weather the hard times," said Lai Rongming, a manager of the company in charge of Chinese mainland operations.
Despite the epidemic, many companies are still active in recruiting new workers. According to Zhaopin, enterprise service and consulting service industries posted most job vacancies in the first week after the Spring Festival holiday, accounting for 6.18 percent of all industries, up 1.5 percent year-on-year. The proportion of jobs posted by real estate, construction and engineering industries also increased by 1.46 percent.


text:
It's always fun to indulge in conspiracy theories, if only because the segment of the population who actually believe in them give the rest of us something to point at and say, "well, things may be bad, but at least I'm not as crazy as that person."
But with all that said, I present to you a conspiracy theory you can get behind. Ladies and gentlemen, I'm here to tell you that March Madness is fixed, and that despite evidence to the contrary, the 2015 Michigan State Spartans and 2014 UConn Huskies are actually the exact same team.
The description on the left is Michigan State in 2015, the one on the right is Connecticut in 2014. Observe:
How is this for crazy coincidences? @ESPNStatsInfo @marchmadness pic.twitter.com/4fDSPRBAxc
— Erik Chard (@21EChard) March 30, 2015
The Illuminati is controlling you! The New World Order is real! Monsanto is making all of us sterile! All of it is true! Anarchy! Anarchy! Anarchy!
Wake up sheeple. March Madness is clearly fixed, and all of your useless brackets won't change a damn thing.


text:
Bible Encyclopedias
1911 Encyclopedia Britannica
Resource Toolbox
A village of British India, in the Darjeeling district of Bengal, 4000 ft. above sea-level; pop. (1901), 1069. It is a frontier market for the purchase of wool and mules from Tibet, and an important agricultural fair is held in November. In 1900 Kalimpong was chosen by the Church of Scotland as the site of cottage homes, known as St Andrew's Colonial Homes, for the education and training of poor European and Eurasian children.
Copyright Statement
These files are public domain.
Bibliography Information
Chisholm, Hugh, General Editor. Entry for 'Kalimpong'. 1911 Encyclopedia Britanica. https://www.studylight.org/encyclopedias/bri/k/kalimpong.html. 1910.


text:
University Of South Wales/Prifysgol De Cymru
Pontypridd CF37 1DL, UK
Contact Number: +443455760101
Website: https://www.southwales.ac.uk
A modern, ambitious university, the University of South Wales makes a real difference to the lives of students, staff and the communities which surround us. With campuses in Cardiff, Newport, Pontypridd and Dubai, the University is renowned for its partnerships with major employers.
Our industry connections and emphasis on equipping students with real world experiences make our graduates among the most employable in the UK, with 95%* of our students in employment or further study within six months of graduating. And throughout everything we do, we strive to stay true to our core values of being Professional, Responsive, Inspiring and Creative.
Primary Address
Pontypridd CF37 1DL, UK
University Of South Wales/Prifysgol De Cymru


text:
It's totally natural for children to look a little bit like their parents and so, with every newborn starts a debate about whether they look more like their mom or like their dad. But in some cases there is no discussion needed, as the kid turns out to be a total clone of one of the parents.
Bright Side has compiled a list of 15 photos showing people who created offspring with a phenomenal resemblance to themselves.


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text:
The 5 Best Videos Of The Week
The first part of Of Mics And Men, the four-hour Wu-Tang Clan documentary, airs on Showtime this weekend. I am ready. This week's picks are below.
5. Open Mike Eagle – "Extra Consent" (Feat. Lizzo) (Dir. Lance Bangs)
The silky R&B shirt is where I started chuckling. The horny dancing notary public is where I lost it.
4. Diplo – "So Long" (Feat. Cam) (Dir. Brandon Dermer)
When I was going to Hollertronix club nights in 2003 or 2004, I could've probably imagined that Diplo would end up at a country festival, doing shots with Guy Fieri. I could've also probably guessed that he'd have a song with Cam; it just would've been a different Cam. Anyway, Stagecoach looks fun as hell, and I'm mad at myself for never having been.
3. Mac DeMarco – "On The Square" (Dir. William Sipos & Sean Campos)
It's nice to see that Clement, Spike's demon friend from Buffy, is still finding work. Looks like he might've had some work done.
2. slowthai – "Nothing Great About Britain" (Dir. The Rest)
I don't know as much about UK social politics as I probably should, but I know enough to know that the image of a rapper using Excalibur to knight dudes in hoodies is some radical shit.
1. Denzel Curry – "RICKY" (Dir. Twelve'len)
The best rap-video treatment of the underground backyard-fighting scene I've seen since Lil Wyte's "I Sho Will."


text:
Thanks for your interest in GoToMeeting for Outlook 2007!
I'm currently working on a detailed video to get you the latest information on this…
But in the meantime…
Checkout the best ClickFunnels offers, benefits, and features below.
In this day and age, the method your organisation runs online can make or break you.
Exactly how do most services presently have a visibility online?
The reality of the matter is, however, that web sites have actually substantially evolved over the previous years – and the approaches of old are no more useful for modern day service.
Back in the day, it would certainly be enough to have a basic internet site with a web page, services, prices, concerning us, and also get in touch with web pages.
A prospective client would certainly go to your site, scroll about, see the various pages and also consume web content as they please.
Nevertheless, if you are an organisation investing any kind of loan on marketing, you intend to manage what customers are learning more about on your website, present deals at the right time, and maximize the profits you make from each person.
How does one accomplish this?
Making use of sales funnels.
Go into ClickFunnels
ClickFunnels is the most convenient method to earn high converting sales as well as marketing funnels.
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It truly is an all-in-one option to produce sales funnels as well as consists of touchdown web pages, email assimilation, invoicing, webinars, subscription websites, and so far more. No wonder it has swiftly become a favorite device for marketing experts.
Below is my thorough ClickFunnels Review, including preferred features, prices, pros/cons, and also comparisons versus competitors.
GoToMeeting for Outlook 2007: But First, Exactly What Is a Sales Funnel?
Sales funnels (likewise called advertising and marketing funnels) are multi-step projects that are developed to relocate possible prospects through your sales process, and turn them right into buyers.
Picture a real-life channel. On top, you pour fluid in, which narrows down in the direction of one taken care of location.
In sales, a comparable occasion happens. On top, visitors come to your website, however not all who get in make it from the other end as purchasers.
Several points need to happen from the time a site visitor enters your funnel, to the time they act as well as efficiently finish an acquisition.
By breaking down the client's journey right into smaller sized steps, you could be a lot more precise regarding how when you offer an offer to your target market.
The in-depth action in a funnel might look something like this:
- Unqualified lead arrives at landing page
- Page communicates the first offer (something totally free to gather an e-mail).
- Once email is accumulated, primary deal is pitched.
- Lead ends up being a paying consumer.
- Even more e-mail communication providing consumer value.
- Further relationship building
- Reoccuring sales.
ClickFunnels also has a visuals that clarifies this in an easy means:.
What is ClickFunnels?
As stated earlier, ClickFunnels is the very best sales funnel software around today.
The firm makes the bold claim of giving you everything you need to market, sell, and also supply your items online – and also they most definitely supply.
A typical funnel will certainly make use of an opt-in page (to gather email addresses), an email automobile -responder (to send emails to your consumers), plus an extra sales page with some content as well as an order kind, perhaps complied with by added web content, a subscription website, and so on
. Formerly, you would need to make use of various systems and also tools to accomplish all these tasks such as:
- Create a web site
- Find Hosting
- Find an autoresponder service
- Discover subscription site software program
- Discover split-testing software program … and so on
Yet ClickFunnels cares for whatever with their platform. You not just save a lots of loan by not needing to acquire various products/services, however you also prevent the technological mess of needing to establish everything up, and could concentrate on what's really essential – expanding your company.
ClickFunnels supplies a Complimentary 14-Day Test, so you get to check out the device as well as truly see if it's appropriate for your company.
Favorite Features
* Quickly Develop Pages Utilizing Layouts as well as Elements *.
Before obtaining also much, it is necessary to comprehend that a channel is a collection of pages created in a strategic order, with the goal of transforming as many leads into consumers. And also a page is merely a collection of numerous aspects made to get a person to take a particular action.
ClickFunnels uses even more than 50 various aspects in order to help you develop the perfect web page. The editor is very very easy to use as well as all you need to do is drag as well as drop different elements on to the web page, and update the text and look to fit your needs – no coding skills needed!
ClickFunnels additionally makes your life easier by offering you with a ton of complimentary templates.
Actually, ClickFunnels offers over 37 kinds of pages for you to mix as well as match with. These are damaged down into the adhering to 10 groups:
- Presell Pages: Study Page, Article Page, Presell Page, Clickpop Web Page
- Optin Pages: Squeeze Page, Reverse Squeeze Web Page, Lead Magnet, Discount Coupon
- Thanks Pages: Thank You Web Page, Offer Wall, Bridge Web Page, Share Page
- Sales Pages: Video Sales Web Page, Sales Letter Page, Item Release Web Page
- OTO Pages: Upsell Web Page, Downsell Page
- Order Forms: 2 Step Order Web Page, Standard Order Web Page, Video Clip Sales Letter Order Web Page, Sales Letter Order Web Page, Item Release Order Web Page
- Webinar Pages: Webinar Enrollment Web Page, Webinar Confirmation Page, Webinar Broadcast Space, Webinar Replay Space
- Subscription Pages: Accessibility Web page, Member's Location
- Affiliate Pages: Gain Access To Page, Associate Area
- Other Pages: Application Page, Ask Page, Shop Front, Home Page, Hero Web Page, Hangout Page, Live Demonstration Web Page
The pre-built themes are fully customizable, and also are just what most customers use.
You are able to choose a template, edit or replace the components with your own, as well as your new page is ready to go.
You can additionally connect any type of channel you produce with your very own e-mail advertising service (if you do not utilize the one consisted of in ClickFunnels), and make use of the ClickFunnels integrated in payment system.
This is likewise a good time to point out that ClickFunnels offers extremely beneficial and understandable training videos when you initially sign up. I highly suggest undergoing those because they quickly enable you to make use of the tool at its full capacity, and also you'll have more enjoyable playing around. GoToMeeting for Outlook 2007
* Develop One-Click Membership Websites *.
Among the very best attributes with ClickFunnels is the capability to easily develop subscription websites and also supply web content to your target market in one location.
Your subscription website will certainly come complete with registration web pages, membership gain access to web pages, as well as web content pages which you can conveniently secure or drip feed to your consumers inning accordance with purchases they made in your channel.
ClickFunnels membership sites enable you to send out emails, quickly handle your e-mails, and construct a community all while eliminating the anxiety that's associated with various other services such as Kajabi, or WordPress systems.
It's really helpful to not have to purchase a separate software application or plugin to create subscription sites.
* Email Combination & Actionetics *.
With every channel comes email checklist structure opportunities.
ClickFunnels supports e-mail combination with all of the major e-mail automation platforms such as:
- Active Campaign
- Aweber
- Constant Contact
- ConvertKit
- Drip
- Get Response
- Hubspot
- InfusionSoft
- Mad Mimi
- MailChimp
- Market Hero
- Ontraport
- Salesforce
- Sendlane
- And others
Nonetheless, ClickFunnels likewise has their very own effective automation device called Actionetics.
Although you could create, routine, as well as deliver e-mails just like other e-mail marketing platform, Actionetics is a lot a lot more.
I enjoy Actionetics because it not just changes your email marketing but carrier advertising and marketing and SMS advertising and marketing software applications as well. This takes automation to a whole brand-new degree and also assists you communicate the perfect message to your consumers, specifically when they require it. A video introduction of Actionetics will certainly be supplied even more listed below.
* Payment and also Payment Integration *.
A remarkable attribute within ClickFunnels is the capacity to accumulate every one of the billing details from your consumers right on your sales page. Marketing is made so much less complicated when customers don't need to leave your website.
ClickFunnels integrates with significant settlement gateways such as PayPal, Red Stripe, and also InfusionSoft, to name a few.
ClickFunnels Pricing.
While you can start with the Free 14-Day Test, there are 3 various rates alternatives with ClickFunnels:
- $ 97/month.
- $ 297/month.
- $ 997 bulk discount plan (recommended).
I'll explain for each of these plans listed below.
1. ClickFunnels Criterion Strategy – $97/month.
The common strategy consists of every one of the features you would certainly require within ClickFunnels, but with limitations on the variety of funnels (20) as well as web pages (100) you can have in your account, in addition to how many site visitors (20K) could view your pages monthly.
You also do not receive sophisticated functionality such as ClickFunnels own email advertising and marketing and also associate monitoring tools.
2. ClickFunnels Etison Collection – $297/month.
This plan consists of all the bells as well as whistles of the standard strategy, without any restrictions. It likewise comes with 2 additional items produced by ClickFunnels called Actionetics (e-mail advertising and marketing) as well as Backpack (affiliate monitoring platform).
In Actionetics – you could manage all your contacts that register for your list, send email programs, and develop a host of other automations. GoToMeeting for Outlook 2007
The difference between the two plans actually is the limitations, as well as Actionetics/Backpack. If you are a fundamental individual and also do not anticipate to make use of greater than 20 funnels in your account – the Requirement Plan need to suffice.
Nonetheless, if you plan to have an affiliate program or wish to maintain your e-mail marketing within ClickFunnels as well as not use a third party software, the Etison Collection is for you.
You can constantly start on the lower strategy and also upgrade if needed.
3. Funnel Hacks System – $997
For anybody that's serious regarding their business, the ClickFunnels Funnel Hacks System is the deal of the century.
The $997 Funnel Hacks System consists of robust training programs packed with 6-month accessibility to the ClickFunnels Etison Suite.
This is an extraordinary bargain because outside of this program, 6-months of Etison Collection alone would cost you $1782.
Not just are you conserving $785 however you're obtaining a ton of trainings and guides to aid you obtain one of the most out of ClickFunnels!
ClickFunnels Advantages And Disadvantages
- Developing funnels is really simple, simple, and also quick
- All-in-one system with every little thing your company should win
- Split screening as well as conversion tracking included
- Email integration with all of the major email autoresponder platforms
- Payment processing capabilities within ClickFunnels
- ClickFunnels is always adjusting and also upgrading to the moments
- There is always sustain readily available (whether real-time or not).
- Unbelievably energetic Facebook Team Area.
- Free 14-Day Test – permits you to try it take the chance of complimentary.
- As incredible as ClickFunnels is, it absolutely is not an economical option and also needs a continual membership to make use of
- Assistance isn't really constantly the fastest and also may take from 1 minute to 24 hours depending upon the problem.
ClickFunnels vs. Everyone Else.
Many individuals ask just how ClickFunnels compares to various other touchdown page contractors such as Leadpages, Unbounce, and also Infusionsoft.
Essentially it's not really a fair comparison since each of these tools stands out is one area or the various other.
The chart above offers a comprehensive evaluation – however I'll highlight some of the significant comparisons below.
ClickFunnels vs Leadpages
Prior to ClickFunnels, Leadpages was the big dog.
Leadpages is merely a lead capture software application – nothing more. You can create touchdown web pages, lead boxes, gather leads … that's pretty much it. In addition, the Leadpages layouts are also restricted on modification.
ClickFunnels is even more flexible – it's much easier to make use of and also does so far more compared to produce lead capture pages.
Simply put, Leadpages is really simply a touchdown page home builder, while ClickFunnels is focused around developing very integrated funnels.
ClickFunnels vs Infusionsoft
Infusionsoft is not a landing page or sales web page builder. It has some of that capability constructed it, however that's not just what it's recognized for.
At it's core, Infusionsoft is a CRM system – one that allows you to manage your whole customer data source. ClickFunnels has this capacity with Actionetics, however it's not almost as advanced as Infusionsoft.
Infusionsoft is additionally extremely costly as well as pressures every brand-new customer to pay $2000 for a mandatory kickstart mentoring bundle just to discover ways to make use of the intricate system (which is infamously tough to use).
ClickFunnels Affiliate Program
There are 2 primary paths people decrease as ClickFunnels customers.
Those that choose to use the tool for their organisation – in hopes of one day accomplish both Comma Club (over $1M in profits).
And also those that have an interest in making easy earnings as a ClickFunnels Affiliate as well as winning the Desire Automobile Competition (where they pay $500/$1000 to your dream auto if you reach 100/200 active regular monthly signups, respectively).
With a massive 40% month-to-month persisting payment, ClickFunnels conveniently has one of the greatest affiliate programs of any kind of system around.
That's right – you get paid an ongoing 40% compensation on every associate signup you make with the ClickFunnels Associate Program. However, just what does that truly correspond to?
The basic strategy is a $97/month financial investment and also the Etison Suite plan is a $297/month investment. therefore you make $38.80 per fundamental strategy as well as $118.80 per Etison Collection strategy … every month!
Usually, every 100 signups will bring in $4000/month in affiliate commissions (basically depending upon how many Etison Plan individuals remain in there).
Click on this link to read more about coming to be a ClickFunnels Associate.
All-time Low Line
ClickFunnels is hands down the best platform if you are planning to quickly develop high transforming sales funnels.
Because it was developed from the ground up to be the best sales funnel home builder, it defeats all the competitors in that regard.
Externally, it could not be the most inexpensive item available – but if you use it to its complete capability, your organisation will certainly end up being extra profitable and you will conserve money from not having to use various other tools. GoToMeeting for Outlook 2007
If you have actually reviewed this much right into my ClickFunnels Testimonial, I suggest you see on your own with a Free 14-Day Test here.


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Why No One Talks About Anymore
Tips for Hiring Limo Service
You may need luxury transportation when you are attending events such as school formals, weddings or corporate functions. Some of the vehicles that offer luxurious transportation are limos, party buses and many others. When you re attending an event, hiring limo service allows you to travel in luxury and convenience. When you need limo services you will find that there are many limo services available to choose from. It is important to ensure that you select the right limo services. The limo service selected will determine the experience you have riding in a limo. When hiring limo service, numerous factors should be put into consideration. When these factors are weighed into your decision, you will be able to select the right limo services. Below are some of the factors you should consider when hiring limo services.
You should first consider your needs. Knowing your needs when it comes to limo services will enable you to select the right services. The first thing to be considered is the type of event you are attending. Some limo services offer transportation for all types of events while others specialize in some events. When you are booking a limo for your school formal, for instance, you should ensure that the limo service caters for such events. Many packages come with limo services. It is important to make sure that you select a package that will be suitable for you. Some packages come with refreshments and entertainment. If you feel entertainment and refreshments will be necessary for you, you should ensure that they are included in your package. The right service will be selected when you know the kind of experience you want to gain from the limo ride.
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The Essentials of – Getting to Point A