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On Sunday, Bengaluru FC plays its inaugural match of the Indian Super League, which kicked off on November 20 in Goa. Through the lockdown months, club captain Sunil Chhetri, 36 — also captain of the national football team and India's all-time-highest goal scorer — says he has has been keeping up with training.
What precautions are you taking?
I am currently in a bio-secure bubble with my club, Bengaluru FC, in Goa for the football season. Every precaution that one can imagine is being taken. We get tested regularly and have zero contact with anyone from outside the bubble that we have created. We wear masks at all times, and are doing all the small and big things right.
Have you got yourself tested for Covid-19?
Yes, we get tested every three or four days. It might seem rather regular, but that is the level of precaution that is being taken.
Have you had to isolate yourself?
Yes, through the lockdown, and the pre-season. My wife and I have been isolating and taking every possible precaution.
What kind of mask do you use?
Nothing in particular. Just a regular mask.
While interacting with people at work, how do you ensure your safety?
There is a long list of safety protocols that we follow. Football is a contact sport. So, on the pitch, it isn't possible to maintain distance like you can in an office job. However, once off it, we wear our masks all the time, space ourselves out at team meals and meetings, and avoid being together in large numbers in small spaces.
What precautions do you take while travelling?
I haven't really travelled anywhere since the lockdown was announced. I made trips to Bellary and then Goa in the team bus. We usually travel in one bus. But this time, we chose to travel in two so that we can maintain social distance when seated.
How much time do you spend in front of a screen?
I don't have a number for that. But it's rather minimal. I don't spend too much time on my phone, laptop or television. However, I do occasionally watch documentaries and shows on streaming platforms.
How do you keep your mind off the pandemic?
Training and resting takes up most of my time. I like my fair share of board games. I have also been catching up on a lot of reading too.
What is the first thing you want to do when the pandemic is past?
I would like to play in a stadium full of supporters in Bengaluru or with the national team — whichever comes first.
Since the un-lockdown, what have you been doing?
We were moving closer to the season. I was spending most of the time training hard and resting as much as I could. Football and fitness aside, I have been playing a lot of Ludo.
Source: Read Full Article

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ERW Takes on Jet Lag with Hydration Pack
There's no two ways about—jet lag sucks. With 2019's total number of commercial flights forecasted to hit 39.4 million, the largest number of flights ever, there are more and more travelers suffering from jet lag. ERW has come up with a Jet Lag Pack that takes on the challenge of jet lag with science.
After study and research, ERW found that the biggest contributor to jet lag is dehydration. Airplane cabins have a humidity level of less than 20 percent. An average man will lose roughly 2 liters of fluid over the course of a 10-hour flight. Chef Hanna Grant and sports scientist Stacy Sims put together ERW after working with professional cycling teams. "The jet lag part was a massive problem for the riders, the team, and the staff," explains Grant. "We've designed a physiologically tailored three-step hydration solution that will combat the effects of travel fatigue, jet lag, and dehydration. The pack consists of three powder sachets. The first, called Prep, is meant to be drunk before boarding a flight. Rest should be taken during the flight, and is designed to help people make the adjustment to flying. "It calms your nervous system and helps you with natural melatonin content," says Grant. "We help you trigger your own melatonin production so that you basically fall asleep. The final sachet, Wake, can either be consumed toward the end of the flight or after landing and is protein based (it contains 21 grams of protein) to help you recover from the flight by increasing blood flow, getting more oxygen to your brain and improving cognitive function. The sachets are all designed to be mixed with 500 ml of water. The drinks also include adaptogens, like Ginseng, which are non-toxic plants that may have benefits for humans. These are included to stimulate hormone production.
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James PeterkaLocke Lord LLP
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Sacrificing Lookman for Aaron Wan-Bissaka would be worth it long-term for Everton
Everton made it four wins from five in the Premier League with a comfortable 3-1 win over Brighton at Goodison Park.
Record signing Richarlison handed the Blues the lead before Lewis Dunk equalised shortly after for the visitors. Seamus Coleman restored the lead after the interval, and the Brazilian grabbed his brace to complete the rout. Marco Silva's fourth win in five games is a testament to the progress the Toffees have made under his tutelage.
One area of concern could be right-back despite Coleman getting on the scoresheet. The Irishman has been plagued by injuries in recent seasons and has failed to reach the heights of earlier in his career. With Jonjoe Kenny providing little competition, Everton should attempt to land another right-back in the January transfer window.
The perfect addition could be Crystal Palace wonderkid – Aaron Wan-Bissaka. Valued at £4.5m by Transfermarkt, the 20-year-old has been the breakthrough star of the season so far after making the right-back berth at Selhurst Park his own. The youngster has made ten appearances in the Premier League, earning plenty of plaudits for his impressive showings.
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The Englishman will be hard to prise from the Eagles, but reports suggest that Everton could offer Ademola Lookman in a possible exchange deal. Swapping Lookman for Wan-Bisakka could prove to be a brilliant deal indeed.
Everton fans, thoughts?
Click here to comment on this articleor
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PS5 Godfall (Deluxe Edition)
Soft Source
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Consumer Advice: General.
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Voice Language: English.
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Godfall is a first-of-its-kind, looter-slasher, melee action RPG. Aperion is on the precipice of ruin. You are the last of the Valorian knights, god-like warriors able to equip Valorplates, legendary armor sets that transform wielders into unstoppable masters of melee combat. Tear through foes as you climb through the elemental realms and challenge the mad god, Macros who awaits you at the top.
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- Become Unstoppable – Level up, learn new skills, and uncover legendary weapons with devastating effects on the battlefield.
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- Vanquish Worthy Foes – Test your skills in the Tower of Trials and challenge yourself against the toughest foes and earn top-tier loot.
- Ascend Together or Solo – Fight solo, or alongside friends with three-player player-versus-enemy online co-op play.


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There are many discounted hotels on Trip.com. Planning a trip to Savona? Savona may not be a metropolis, but there are still great hotel options on Trip.com. You can plan a day tour in Savona.
Though there is no civilian airport, it's still easy to take a bus or train to reach Savona. It's easy to travel by bus in Savona. There are buses to surrounding cities available every day.
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• July to September: 24.93°C during the day, 21.14°C at night
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• Summer: 59.33 cm
• Autumn: 46.33 cm
• Winter: 88.33 cm


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Article content
JERUSALEM — Palestinian militants fired rockets from Gaza into Israel on Tuesday, the Israeli military said, at same time as Israel and two Gulf Arab states signed normalization agreements at the White House in Washington.
Warning sirens sounded in the coastal cities of Ashkelon and Ashdod as Israeli Prime Minister Benjamin Netanyahu and U.S. President Donald Trump met the foreign ministers of United Arab Emirates and Bahrain at the White House.
tap here to see other videos from our team.
Palestinians fire rockets into Israel, wounding two, during White House ceremony Back to video
Israel's Magen David Adom ambulance service said paramedics treated two men for light injuries from flying glass in Ashdod, and four others suffered shock.
An Israeli military spokesman said the Iron Dome anti-missile system intercepted one of two rockets fired from Gaza.
In Gaza, which is controlled by the Islamist militant group Hamas, dozens of Palestinians rallied outside a U.N. office to condemn the normalization deals shortly before the signing ceremony began.
"Palestine isn't for sale," protesters chanted.
Sami Abu Zuhri, a Hamas spokesman, said the Bahrain and UAE agreements would not bring Israel peace in the region.
"Peoples of the region will continue to deal with this occupation as their true enemy," he told Reuters, speaking from Turkey. Hamas did not claim responsibility for the rockets.


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A well-defined structure and straightforward variant, Purple Urkle is a seed strain that is easy to grow. It can be grown in any given environment. With that, developing it in an indoor and outdoor growing setting will not going to be an issue. With its resiliency, this seed strain can combat against molds and pests that could considerably damage its roots.
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Graham Tobin
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Mexico Tourist Land Visa - What Is It?
Registering for one, or all 3 groups, is a good chance to meet like-minded people even though you are in town. Ok, it was not quite as easy as that, but you have the picture. It's possible to travel a day or two or spend months discovering South America. Trust me it will be a lot easier getting temporarily documents this manner. Know in advance how you are going to be receiving around. This is the very first time I have experienced something similar to this, it really is a restaurant which provides you a tab when you're a lounge member (Priority Pass).
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USD U.S. dollar
A stay at Zanhotel Regina places you in the heart of Bologna, within a 10-minute walk of Fountain of Neptune and Piazza Maggiore. This hotel is 0.5 mi (0.8 km) from Museum of Giorgio Morandi and 0.5 mi (0.8 km) from Palazzo Comunale.
Make yourself at home in one of the 54 air-conditioned rooms featuring minibars and LCD televisions. Your Select Comfort bed comes with Frette Italian sheets. Complimentary wireless Internet access keeps you connected, and digital programming is available for your entertainment. Private bathrooms with showers feature complimentary toiletries and bidets.
Take in the views from a garden and make use of amenities such as complimentary wireless Internet access and concierge services.
Featured amenities include limo/town car service, express check-in, and express check-out. A roundtrip airport shuttle is provided for a surcharge (available 24 hours), and self parking (subject to charges) is available onsite.
Satisfy your appetite at the hotel's coffee shop/café, or stay in and take advantage of the room service (during limited hours). Quench your thirst with your favorite drink at the bar/lounge. A complimentary continental breakfast is served daily from 7:00 AM to 10:00 AM.
Extra-person charges may apply and vary depending on property policy.
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Culture by Nicolas Towner Nov 16, We delete comments that violate our policy , which we encourage you to read. We bought one for the house and then two for our businesses because the first one worked so well. Works great, even when all 9 ports are used along with the power port. We have a 2 story home, with up to 5 devices accessing the modem at a given time. Turn an old monitor into a wall display with a Raspberry Pi Turn an old monitor into a wall display with a Raspberry Pi by Taylor Martin. Not going higher than three stars though, due to the poor customer service.
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Whether you want to change your cold, drafty windows or merely desire to boost the total appearance of your house, you will need to go in for replacement windows even though picking the best replacement windows is a burdensome task and involves a considerable investment.
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Breast cancer treatment is most successful when it is diagnosed and treated in its earlier stages. Knowing how to check the signs of early breast cancer through the help of breast self-exams and breast cancer screening tests are critical to overcoming the disease.
In the Philippines, the number one cancer affecting Filipinas is breast cancer, followed by cancer of the cervix uteri, colorectum, lung, and ovary. In 2018, it was reported by the Global Cancer Observatory that breast cancer accounted for 31.4% of new cancer cases in women, totaling around 25,000. Despite it being a highly treatable disease, many women still lack the information to detect its symptoms accurately.
What is Breast Cancer?
Breast cancer is a type of cancer that forms in the tissues of the breasts. The two main types are:
- Ductal Carcinoma occurs in the tubes that channel breastmilk.
- Lobular Carcinoma begins in the surrounding mammary lobes.
Breast cancer mostly affects women, but there have been cases of this type of cancer developing in men, though it is quite rare.
While a dangerous disease that can end in fatality, breast cancer is highly treatable. Many cancer survivors can live long, fulfilling lives. It is crucial to detect the early signs of breast cancer. Doctors can diagnose the disease accurately using breast cancer screening tests. If doctors can confirm cancer in the earlier stages, then chances for survival are higher.
How to Detect Breast Cancer?
Women usually detect the first signs of breast cancer through a self-breast exam, which entails cupping the breast and feeling for any irregular lumps or dimples. Women's breasts are different and unique and change as they age, so it is encouraged that women regularly do a self-exam to get a feel of what is "normal."
Most lumps are harmless and may appear and disappear on their own throughout a woman's menstrual cycle due to changing hormones. Most have benign causes. But to be sure, it's best to consult your doctor and undergo breast cancer screening tests if necessary.
What Are the Signs and Symptoms of Breast Cancer?
But women should always take note of changes in their breast, which may point to other serious conditions.
Here are some symptoms of breast cancer:
- Lumps that grow hard
- Thickening of tissue that is different from the rest of the breast
- Changes in the breast in terms of texture, contour, and even temperature
- The nipple becoming inverted
- Clear, bloody, or colored discharge from the nipple
- Burning/ hot sensation
- Itchiness
- Swelling
- Pain
If you have any suspicions about lumps and changes in your breast, consult your doctor.
What Are Some Tests that Help Detect Breast Cancer?
After a physical exam, and to make a more informed and accurate diagnosis, your doctor may request you to undergo a few breast cancer screening tests to confirm the condition.
These may include:
This is usually one of the first breast cancer screening tests requested by your physician. The mammogram uses X-rays to capture an image of the breast and identifies any calcification points. Mammograms, when applied to diagnose breast cancer accurately, can help reduce mortality by 30%. Women over 40 years of age are encouraged to undergo a mammogram every 1 to 2 years.
In some cases, women do not experience any symptoms or do not see any physical changes in their breasts, especially in the early stages of breast cancer. Thus, mammograms can help detect even the smallest of changes in the breast tissue.
Breast Ultrasound
Unlike mammograms that use X-rays, this method uses high-frequency sound waves to capture the image of the breast. When the sound waves pass through or bounce off breast tissue, it creates an image that helps detect any suspicious growths. It can help determine the nature and size of a tumor. This ultrasound method is one of the most preferred breast cancer screening tests used by doctors and patients, because it is non-intrusive, painless, inexpensive, and is safe for all ages. It is safe, even for pregnant women. It also produces results faster.
Breast MRI
Breast magnetic resonance imaging, also known as breast MRIs, uses more sophisticated technology and provides more detailed information about the breast tissue, lesions, and tumors. Its sensitivity is higher than M-rays, making it one of the effective breast cancer screening tests for diagnosis.
Aside from being more expensive than the other exams, breast MRIs are often only recommended when screening women with higher than average risk.
To determine whether a lump is benign or cancerous, the doctor may request a biopsy. The biopsy entails getting a sample of breast tissue that lab technicians will then analyze. A specialized needle will remove core tissue from the suspected area. Usually, a breast biopsy is an outpatient procedure.
Biopsies are highly beneficial breast cancer screening tests as they provide key information about the type of cells in breast cancer and can help determine the aggressiveness of cancer. A biopsy can also help provide other critical information that doctors need when putting together a treatment plan for you.
Radioisotope Imaging of Breast Cancer (FDG-PET)
This method helps locate a tumor or a cluster of tumors before an operation. This is more sensitive than X-rays and provides more detailed information that can help in the treatment and removal of tumors or lumps in surgery.
Though it uses radiation, it is a very low dose, with a half-life of six hours. This is considered very safe for patients.
Key Takeaways
Breast cancer screening is crucial in diagnosing breast cancer. Breast cancer is a highly treatable disease that has a high survival rate. According to a study, the average 5-year survival rate of women with invasive breast cancer is 91%, while the 10-year survival rate is 84%. If the cancer is limited to only the breast, then the 5-year survival rate goes up to an impressive 99%.
What is key to successfully overcoming breast cancer is early diagnosis and treatment. Appropriate breast cancer screening tests can help in this regard.
Learn more about Women's Health, here.
Hello Health Group does not provide medical advice, diagnosis or treatment.


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Flawed but fascinating.
Locker Room Talk returns to the Traverse theatre after its acclaimed run in 2018. The piece was born out of research conducted by playwright Gary McNair who set about recording 'what men really say about women when women aren't around'. The project gets its name, of course, from the infamous comment made by Donald Trump in which he attempted to pass off misogynistic comments as mere 'locker room talk'.
His dismissal betrays a misconception that his words could not do harm if not heard by women or that the views he holds about women are ubiquitously held by men. According to Locker Room Talk, however, it would seem they are.
McNair's research is compiled to create the text of the play. The words of men interviewed either alone or in groups of friends or colleagues are relayed verbatim by four impressive actresses, Maureen Carr, Jamie Marie Leary, Gabriel Quigley and Nicola Roy. They perform whilst listening to the interviewees' words through headphones, mimicking the tone and intonation they hear.
The overwhelming majority of comments are caricatures of base, ill-informed and un-nuanced misogyny. The men banter with each other and compete to be the most graphic or most vulgar. Their comments hold violent, sexually predatory intentions: for these men, women exist only to 'cook and be f***ed'. They speak of scoring systems to 'rate' women's looks with little shame or self-awareness. There was glee and even pride in some of their comments. These were not well-developed insights into the systemic misogyny ingrained in normally empathetic men. Not one discussion of feminism was articulate or well-informed.
Despite this, neither I nor, gauging by opinions voiced in the post-show discussion, any other non-male-audience-members, were surprised by what we heard. The interviews present opinions about women so abhorrent, so archaic and so clichéd that I could not bring myself to be enraged or offended. I was left just with melancholy. None of these views were new to the audience – I am well aware that there are men who hold and are willing to share, impose, and act upon their hatred, confusion, or predatory sexual attraction towards women.
When performed with finesse and nuance by the fantastic cast, many of the comments were almost comic (the comparison of women to 'squirrels' was a strong example). Having the words spoken by women underlines the absurdity of misogyny and confirms that we do hear what is said. Men may believe that they are out of earshot, but in this case, the recordings are directly in the actor's ear. Thus, the performance asks male audience members, would you say such things, even for comic effect? Would you dare say them in front of a woman, and if not, why not?
There was an overwhelming lack of men interviewed who were willing to speak articulately about feminism or the damaging nature of 'locker room talk'. A few did, but with little conviction. This was a key flaw in the structure of the play, as it confirmed Trump's assumptions and presented a disproportionately bleak picture of gender relations. Much as I was unsurprised by the predominance of objectionable views, I was surprised by the absence of more informed ones. I know they exist, and some I believe were held in the audience. It would be foolish to believe otherwise. The piece needed alternative opinions, not to appease misogynists or to 'soften the blow', but to encourage a more nuanced conversation about what is an undeniably nuanced subject.
Leaving the theatre, I felt compelled to look further into McNair's research, to find out how many men were interviewed, how many of those interviews were discarded from the script, the ages and occupations of the men interviewed, and how willing were they to be involved. The aim of the performance was to suggest that extreme misogyny is pervasive, but perhaps that is not enough for a female audience who live with and navigate the realities of this.
Nevertheless, this is utterly fascinating research performed with skill by the four actors. Locker Room Talk is certainly not perfect, but it is compelling to watch and contributes to a crucial conversation.
PHOTOS: Mihaela Bodlovic and David Monteith Hodge
Laura Hounsell
Latest posts by Laura Hounsell (see all)
- Tosca – Festival Theatre - 21st November 2019
- Locker Room Talk – Traverse - 25th April 2019
- (Can This Be) Home – Traverse - 1st April 2019


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Veggie Chili
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- 2 oz avocado oil or canola oil
- 2 medium eggplants (peeled, cut into 3/4 inch cubes)
- 5 t chili powder
- 3 t ground cumin
- 1 1/2 t ground coriander
- 1/4 t ground cinnamon
- 1 small yellow onion (peeled, medium dice)
- 1/4 cup fresh oregano (leaves removed, chopped)
- 1 red bell pepper (seeded, medium dice)
- 2 cloves garlic (peeled, minced)
- 1 jalapeno (stem removed, minced)
- 6 t unsweetened cocoa powder
- 1 cup green lentils (thoroughly rinsed in cold water, drained)
- 4 cups vegetable stock
- 1 can diced tomatoes (15oz)
- cilantro (to garnish)
- jalapeno (shaved, to garnish)
- kosher salt and freshly ground pepper (to taste)
Step 1
1. place a large Dutch oven over medium-high heat and add the avocado oil. add the eggplant and cook until it starts to soften and brown, about 6-7 minutes. season with salt.
2. add the chili powder, cumin, coriander, cinnamon, cocoa powder, and oregano, stirring to coat the vegetables. add the onion, bell pepper, garlic, and jalapeno and cook until the vegetables soften and become aromatic, about 4 minutes
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4. Tip: add your favorite vegetables to this chili. if you prefer no cocoa powder, simply remove for a flavorful soup.


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Cracking the Aging Code: The Science Book of the Year
In his new book, Cracking the Aging Code: The New Science of Growing Old and What It Means for Staying Young, Josh Mitteldorf — who has studied aging for decades and writes about it at his website — explores the science of aging and sets forth his own theory as to why we (and virtually all organisms above the level of bacteria) age. (The book's co-author is Dorion Sagan, but the theory is Mitteldorf's.)
This is the science book of the year, the best I've read in quite a while.
Mitteldorf is an expert in evolutionary theory — although used to be an astrophysicist — and he deftly and skillfully expounds and criticizes the several current theories of aging. He then proposes his own radically different theory. He's very convincing. Whatever the fate of his theory, he brings enough evidence to bear both in its favor and against the other theories that, it seems to me, his theory must at least be reckoned with.
A thorn in the side of evolutionary theory
Aging has been a thorn in the side of evolutionary theory since the beginning. Even Darwin knew and understood this and could not see a way to incorporate aging into the theory of evolution.
Aging poses a conundrum for evolutionary theory because aging manifestly decreases biological fitness, causing lower reproduction and greater mortality. Why wouldn't evolution have abolished it, or not allowed it to come into existence?
If an organism didn't age, it would seem to have an advantage: it would never die of aging and it would continue to reproduce throughout its lifetime; hence the longer an organism lived, the more offspring it would leave, and the fitter in evolutionary terms it would be.
Indeed, we do see this in some organisms. Lobsters, for example, apparently do not age, but grow bigger and more fertile with the passage of time. The record weight for a lobster was 44 lbs. Mitteldorf describes some species of long-lived shellfish, which are almost nothing but feeding and egg-laying machines, cranking out a million eggs daily.
But humans and most animals do age. Animals in the wild have a greater risk of death from predators and infections the older they are. Why hasn't evolution put a stop to this?
One older idea, that of Peter Medawar, is that the force of natural selection declines with age. If an organism has aged and then dies, any genes that contributed to aging and death have already been passed to its offspring. The idea is that some genes that may cause aging are also necessary for growth and reproduction. Therefore natural selection is unable to eliminate the genes for aging.
Medawar's idea led to the three main modern theories of aging.
Mutation Accumulation: Genetic mutations are always present in a population; in other contexts, this is known as genetic load. If a mutation is not severe enough to cause death, but causes only, say, a 1% decreased level of fitness, then these genes can stick around in a population for a long time. Essentially, natural selection has not had enough time to get rid of them. An example might be the ApoE4 gene, which raises the risk of dementia and heart disease.
But even a 1% difference in fitness is, as Mitteldorf says, "far from being invisible to natural selection." Aging animals do not die of senescence usually, but they die at a much greater rate from disease and predators than younger animals. In some arctic species, 60% of deaths in the wild can be attributed to aging. Natural selection should be capable of eliminating the genes that cause this huge death toll, and to be able to do it quickly.
Antagonistic Pleiotropy: Some, maybe most, genes have multiple functions, and this theory says that genes with important functions in youth cannot be weeded out when they cause aging. An example of this might be the hormone IGF-1, which is involved in both growth and aging. Mice without it die shortly after birth — but high levels in older people are associated with cancer and higher mortality.
Mitteldorf describes the work of Michael Rose, who bred fruit flies for longevity in order to see what would happen to fertility. In theory, if he selected long-lived flies and bred them for longevity, their fertility should decrease, given antagonistic pleiotropy. But that's not what happened; their fertility went up. So there seems no reason that nature can't separate the function of fertility from aging.
Disposable Soma: Resources, usually in the form of food energy, are always in short supply (so this theory says), so organisms must allocate these resources to different needs. Damage repair at the cellular level is one of those needs and is an important component of aging since if the body can repair all of its damage, aging will not occur. So if resources are lacking, the organism allocates them preferentially to growth and reproduction, and essentially allows itself to age.
The striking evidence against this theory is calorie restriction, the most robust life-extending intervention in lab animals. When they are literally starving, animals can live 50% longer than normally fed animals. If resource scarcity were causing aging, we could expect to see the opposite. If you ate more, you would live longer; but that is manifestly not the case. Eat more, die younger — and this holds true for virtually every species of organism which has been put to the test.
Same is true for exercise: if damage and repair are crucial for aging, then exercise would make you age faster. Exercise causes damage — yet it makes animals, including humans, live longer.
Both calorie restriction and exercise are examples of hormesis, in which the application of a stressor or toxin causes better health and longer life. The organism doesn't just repair the damage but becomes stronger and healthier than before.
Hormesis is central to Mitteldorf's theory of aging. As he says, it looks as if the organism already has potent anti-aging capabilities that, in normal, "easy" times, it does not use. The organism is fully able to slow aging when the conditions are right.
Aging is not damage that the body can't control or that natural selection can't abolish. It isn't due to lack of resources or pleitropic genes. No.
Aging is programmed.
Programmed aging and group selection
The theory of programmed aging clashes directly with the neo-Darwinian theory of evolution, which is the theory that represents current thinking in biology.
Neo-Darwinian theory states that natural selection takes place at the level of the gene, and only benefits individuals carrying that gene.
Mitteldorf's theory of programmed aging relies on group selection, a notion that most evolutionary scientists say cannot exist, or if it does, is not powerful enough.
Hence my description of Mitteldorf's theory as radical, since it takes on the entire neo-Darwinian synthesis, and the scientists that back it.
In this light, it's of more than passing interest that Mitteldorf's mentor has been another proponent of group selection, David Sloan Wilson, the author of the masterful book Darwin's Cathedral: Evolution, Religion, and the Nature of Society.
The programmed theory of aging sees aging as a "suicide program", one that is of no benefit to the individual but which is of great benefit to the group. The organism dials up genes that cause inflammation and other forms of damage, leading to aging and death. Aging is a deliberate effort on the part of the organism, not something it tries to avoid.
Why would organisms do this? The benefit to the group would have to be a very powerful one in order to override the harm to the individual. And indeed it is, according to Mitteldorf.
Organisms age in order to avoid extinction.
In any successful group of organisms, it appears easily possible for the group to overshoot its environment and to succumb to famine or other causes.
All animals are predators in some way or other, depending on other life forms for sustenance, and if the animals are too successful, they risk famine or epidemics and subsequent extinction of the entire group.
Aging is the organisms' way of buffering the population. In good times, with plentiful food, organisms age and some of them die, thus keeping the group within its environmental limits and in tune with its ecology. The group thrives.
In bad times, with fewer available resources, aging slows. The species does not want every member to die at once, of famine or some other cause. It wants to avoid extinction, an event which means the demise of every gene carried by the species. When the crisis is over, aging resumes.
Mitteldorf supplies abundant evidence for his theory, and it makes for fascinating reading. While reading it, I thought of a few objections, which wasn't easy, as the author is convincing. Note that I am not an evolutionary biologist.
Aging seems too messy a process to be a "suicide program." If you think of all the ways that aging causes damage, illness, and death, how could multiple sources of these things arise? One gene that caused death would be a lot simpler, and the fact that aging apparently has multiple genetic roots makes one wonder how it could arise by natural selection.
Admittedly, this objection is probably more a matter of taste in theories than one with empirical backing.
Another objection is that the mere passage of time seems involved in some aspects of aging, for example, in the accumulation of iron or exposure to microbial antigens.
Iron seems a good example of pleiotropic effects: it's necessary for growth and reproduction, but causes aging. Furthermore, natural selection might be unable to eliminate its effects on aging. Women with higher iron are more fertile, which might swamp the effect of natural selection on iron causing aging after a person has already had children.
Antigen exposure comes from infectious agents and is a primary cause of inflammation in aging. The longer we live, the more antigens we're exposed to, and those exposed to more diseases die younger, i.e. they age faster. But perhaps the organism can't dial down inflammation since we need it to fight off pathogens.
Cracking the Aging Code is the best book I've read this year, and it should be required reading for anyone interested in aging or indeed evolution and biology. Mitteldorf skillfully wends his way through evolutionary theory, its history, and the biology of aging — he even knows his way around field biology and ecology.
At the end of the book, he discusses the prospects for anti-aging research as well as what he believes are the best means of slowing aging that we have right now.


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For reasons beyond our control, the information on the product labels may vary, therefore if you find discrepancies between the information on the label and those reported on the site, we invite you to report it to us and always check the information on the product before its consumption or use.