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MEXICO CITY, Sept. 17 (Xinhua) -- Mexico's export and tourism sectors are likely to suffer from "stress" beyond 2021 due to slow economic recovery from the COVID-19 pandemic, credit rating agency Moody's said Thursday.
In a report titled "Full recovery for Mexico's corporate sector still two years away," the agency said "stress in Mexico's export- and tourism-dependent economy is likely to persist beyond 2021, even as economic growth recovers from a severe downturn in 2020, and a full recovery is at least two years away."
The agency said it expects Mexico's economy to rebound 3.7 percent in 2021, after contracting 10 percent in 2020 due to the pandemic.
The tourism sector will not return to pre-pandemic activity until 2023, as its full recovery will depend on consumers feeling comfortable traveling, which surely will not occur until effective vaccines and treatments are widely available, the agency said.
Moody's sees little improvement in 2021 for the airline, airport and hotel sectors, which have been severely affected.
However, sectors focused on consumption, including packaged foods and telecommunications, will see a gradual recovery, it said.
Mexican President Andres Manuel Lopez Obrador estimated the country will lose 1 million jobs in 2020 due to COVID-19, and said his administration is looking for ways to generate up to 2 million new jobs.


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Ariana Grande is growing as a musician, and her upcoming album reflects these changes.
Although we still don't have a release date for the Sam & Cat star's sophomore record, it's obviously preparing to hit physical and digital shelves at some point in the near future. This writer suspects that the record will arrive before the end of the summer. Of course, that's pure speculation on our part.
However, he lack of a release date doesn't mean Grande has nothing to say about the upcoming album. In fact, she's eager to talk about the project whenever the opportunity arises. During a brief chat with the folks over at Boca Raton magazine, Ariana said the record shows how much she's changed since the release of Yours Truly.
The singer told the publication:
"I think it shows my progression as an artist and as a person … It's a little more grown-up, while still remaining authentic to me as a person. I'm very excited for people to hear it."
It's obvious that Ariana has put a lot of time and effort into the new batch of songs. Grande recently told Billboard that she's a workaholic and a perfectionist, which means she put as much energy into this project as humanly possible. However, it's still unclear if all this hard work will pay off at the end of the day.
"It was a very exciting thing for me to all of a sudden have this new mission, to make something as special as Yours Truly, and to put my time and effort into something new and something I want to make just as good, if not better," Ariana told the magazine.
Grande said about her latest single:
"'Problem' truly represents the feeling of being absolutely terrified to re-approach a relationship that's gone sour — but you want to more than anything. In the song, it ends on a sappy, negative note, but in [real] life, we're hoping it's going to end on a positive one. I feel like it's all very honest and human."
Judging from the success of "Problem," the singer shouldn't have any trouble getting folks to buy the upcoming album; the song is still riding high on the iTunes songs chart at the moment. If this the tune's success is any indication of things to come, then her Ariana Grande's sophomore record should sell tons of copies when it arrives later this year.
[Image via Bing]

subset: commoncrawl


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Those people who did not get great parenting have a tendency to create our spouses responsible for making it up to us. There is a role in every one of us that desires our love partner to present the parenting we didn't get from mothers and our mothers. For many, this part is big; for others, it is small. While this happens in a love affair, it results in the demise of the connection. Adore partners are happy to make up for the parenting we did not receive when we were little.
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Rather than composing a generic subject line that will probably get deleted, backpage escorts Las Vegas us check out some time tested, proven messages which have female Message All- Stars reacted to and opened. Consider that others might have used them as well change them up a bit if possible. The Question- Ifyou're interested in a man, have a look at his profile and see if there is. Consider making it humorous and have fun! For instance: If they like to play golf you could add comedy and place in the subject line: " Golf classes? " Or if they play guitar. . . " Guitar Lessons? " I am curious what warm sounds like, will you please send me a snippet. The guitar intrigues me. . . I simply started lessons and can't get enough. Is there a backstory on this particular best sex dating ap photo? Would really like to hear more- Take care, Jen The Cliff Backpage escorts- - This uses components from his profile to start a narrative, which does not have a finish. For instance: what happened when the man from( add a couple of items they like from her profile) fulfilled( enter your handle or title) .
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Keep Trying. This technique does not always work but you ought to try it all the time. Not every women may react to you. If she reacts to you, she might not wish to take the dialogue further or might not be excessively responsive.
Guys- What Not calls or charged remarks. Whenyou're a teenager to find a female's 15, this might have worked. And you have seen it work in the films. But that is the exact same place you saw E. T. fly overhead using an entourage of kids on bicycles too. Can you think that? It's been my observation that catcalls and dumb lines when they are in the existence of different men are often used by men. The way would be to employ those techniques. It does not show confidence it implies hookers in your area Sugarmill Woods FL. Catcalls will not stack the odds in your favor.
As I write this, I had a lot of courses to learn about lifestyle. Some lessons have been so difficult that I almost doubted becoming a Twin Flame. Lessons I learned them. And the most difficult lessons are those which involved unlearning mental ailments and my past bad habits.
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You may find that in the event you wait, your partner will come to the identical decision as you. If he or she asks you for a solution directly, don't offer it away. Ask what she or he would suggest to you if the roles were reversed. Always attempt to give the power back to your partner.
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Naturally there will be those homes where it appears and their house seems like it. If you went into a home what do you do? You would probably make it seem likeyou're interested for a minute and then left.
Getting to know somebody entails getting them to start up a tiny bit, right, when you are dating? Let's say you have gotten to know what I call the layer that is outside and you have been dating for three or four weeks. That is who and how much you are shown by them in the start. You begin to think that you understand this innermost layer, if, at this stage, you are sleeping with him. However, what's in the middle here, in this handy dandy little onion diagram, are two more important layers of about.
No wonder a lot of guys find this a task that is difficult if not impossible and consequently go throughprotracted'spells' If you opt to utilize the world wide web to meet with women it doesn't indicate you don't have to put any effort into it. You face stiff competition as you want fromthe'realworld' so it's casual sex atalnta desi Sugarmill Woods Florida to understand how to learn the procedure for internet and that means havinga'rock' system in place. Without a good system in place you might as well throw your money down the drain when it comes to online dating and even in the event that you decide to use only free websites, you will still be squandering resources in duration of time, net costs, etcwhich could be spend doing anything else such as pursuing your hobbies and interests or visiting your loved ones members and friends.


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Nearly 20% of people experience this before anything else.
It's complicated...
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An internet rumor has been circulating that all UA math courses will be online in the Fall. This is not true. For the safety of students and faculty, UA has imposed social distancing requirements which have significantly reduced the occupancy limits on all classrooms, and limit face to face interactions between students and instructors. Because
How a Crimson Beard Raised Funds for West Alabama Food Bank
A before and after of Dr. David Cruz-Uribe's gray beard (top) and Crimson Storm beard (bottom). From the June 2020 Desktop News | What began as a joke at the end of an email quickly became an act of service for UA's department of mathematics, which recently completed a faculty fundraiser for the West
Martyn Dixon's Presentation to the Ischia Group Theory Conference
Professor Martyn Dixon gave a talk to the Ischia Group Theory Conference on May 21, 2020 to the Ischia Online Group Theory Conference (GOThIC). This presentation can be viewed at https://drive.google.com/file/d/1foe_6nJzmU4BkxxINm-Ov8U-kJlg-MMe/view
David Cruz-Uribe's Talk to Universidad National del Litoral
David Cruz-Uribe, OFS, presented his research entitled "Norm inequalities for linear and multilinear singular integrals on weighted and variable exponent Hardy spaces" to the Seminario del IMAL "Carlos Segovia Fernández", CONICET, Universidad National del Litoral, Santa Fe, Argentina This talk is available on YouTube at https://www.youtube.com/watch?v=ff-cLnsB7LA&t=5s
Math Department Raises Money for West Alabama Food Bank
Our Chair, David Cruz-Uribe, was lamenting his greying beard and was threatening to dye it. The department called his bluff and offered to raise money for a local charity if they could pick the color. He accepted the challenge and the department promptly raised over $500 for the West Alabama Foodbank. The winning color was
Video Messages to Graduating Seniors and Honors Day Award winners
Since COVID-19 prevented us from holding a Honors Day reception and a commencement ceremony, Dr. Cruz-Uribe created the videos below to speak to our students. Undergraduate Awards: https://vimeo.com/414761564/310e89b791 Graduate Awards: https://vimeo.com/414762604/02e48bd5d9 Class of 2020: https://vimeo.com/414764562/4970e370e0
Promotion News
Provost Kevin Whitaker announced today the follow promotions which will take effect during the Fall 2020 semester. Congratulations go out to Wei Zhu who was promoted to Full Professor, Shibin Dai who was granted tenure and Yuhui Chen and Tim Ferguson for their promotions to Associate Professor.
Jeremy Cummings Wins the 2020 Randall Outstanding Undergraduate Research Award
Jeremy Cummings was selected as a recipient of the 2020 Randall Outstanding Undergraduate Research Award for his research entitled "Weighted norm inequalities for the maximal operator on variable Lebesgue spaces over spaces of homogeneous type". Jeremy was nominated for this award by Dr. David Cruz-Uribe. He will be honored at a luncheon later this month.
Involvement Builds Sharniece Holland's Success
Sharniece Holland is a proven leader who demonstrates driven tenacity toward her goals – academically and professionally. Now a professor at Washington University, she earned her master's and doctoral degrees at The University of Alabama.
Mathematics Strives to Be a Leader in Diversity and Inclusion
The Department of Mathematics was awarded the 2019 Departmental Diversity Award. Dr. David Cruz-Uribe's goal is to maintain this diverse atmosphere, eventually creating a graduate program that is made up of 50 percent women and 20 to 25 percent underrepresented minorities.


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More troubling news about the African church. This time in Nigeria. The king of Ile Oluji (Alayeluwa Oba Engr) is pictured. Couldn't resist the hat!
HELL was let loose yesterday as irate youths in Ile Oluji area of Ondo State threw explosives inside the St. Peters Anglican Church to protest the appointment of a new Bishop for the newly established Diocese in the town.
Also, elders of the town displayed placards in rejection of the appointment of the new Bishop of the diocese Venerable Christopher Omotunde.
Those against him raised nine-point ground of objection to the appointment and urged the primate to rescind the decision and appoint a new Bishop for the diocese.
Some of the placards carried by the protesting members of the church read "We reject Omotunde as our Bishop", "Omotunde is not fit to be our Bishop".
Vanguard learnt that the Sunday service was abruptly halted as the youths stormed the church and threw the explosives.
Omotunde was said to be away to Abuja when the youths stormed the church yesterday.
Some people were said to have been injured as the worshipers fled to different directions for fear of being hurt by the explosives.
The yearly annual children harvest slated for yesterday was abruptly concluded following the noise of the explosive that scared the children out of the church. Some of the youths however threatened to march to Vicarage and burn it even as pleas for pastors and elders of the Church were rebuffed by them.
Tuesday, November 18, 2008
Appointment of new Bishop tears Ondo Anglican Church apart
3 comments:
- Andy Muhl said...
"The yearly annual children harvest..."
Wow, how do they harvest their children? Do they grow in fields or on trees?
- November 18, 2008 at 12:56 PM
- Celinda Scott said...
I couldn't find out on-line why this bishop was disliked. Does anyone know?
- November 18, 2008 at 8:24 PM
- Jim Simons said...
I thought that was odd too Celinda. Its often typical of the African papers I read they don't answer the question they raise which in this case is "why".
BTW Andrew - Never heard of cabbage patch kids?
- November 18, 2008 at 8:56 PM
Subscribe to: Post Comments (Atom)


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Amnesty International sparked a hollywood outcry this week whenever it circulated a draft proposition calling when it comes to decriminalization of "all areas of intercourse work" to safeguard the legal rights of intercourse employees. But intercourse employees and intercourse worker advocacy groups generally offer the proposition, saying decriminalization or legalization may be the simplest way to help keep intercourse employees safe and healthier without enhancing the quantity of trafficked females or minors active in the intercourse industry.
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The full Skoove Blues & Boogie piano course is online. 20 new lessons for you to learn Blues & Boogie for piano!
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Polymorphonuclear neutrophils (PMNs) are the most abundant circulating blood leukocytes. They provide the first-line defense against infection and are potent effectors of inflammation. In addition, their release of soluble chemotactic factors guides the recruitment of both nonspecific and specific immune effector cells.1 Finally, since they both respond to and produce cytokines,2,3 they also modulate the balance between humoral and cell-mediated immunity by contributing to the promotion of a TH1 or TH2 response.4 In these ways, PMNs are engaged in a complex cross-talk with immune and endothelial cells that bridges innate and adaptive immunity.5
Even though many facets of their biology have been thoroughly investigated,6 PMNs still have every reason to complain of the disdain with which they are regarded by oncologists and immunologists.2 So widespread is T-cell chauvinism7 that the antitumor potential of PMNs continues to receive little attention, and researchers have not yet fully considered the possibility of exploiting their functions as effective weapons against cancer.
Natural antitumor activity
The attempts of leukocytes to respond to cancer are suggested by their systemic, regional, and intratumoral activation.8-10Infiltration of tumors by leukocytes has been associated with a favorable prognosis in some studies in humans.11-13However, for individual patients, there is no predictable relationship between leukocyte composition and the prognosis of their disease.
PMNs are usually a scarce reactive component of both human and animal tumors. In animal models, their presence may sometimes be detrimental by favoring malignant growth and progression.14Nevertheless, recent studies have suggested that they are active in immunosurveillance against several tumors.15-18 These intriguing outcomes are probably related to the result of the interplay between (1) the kind and amount of cytokines and chemotactic factors naturally released by tumor cells19 and (2) the degree of recruitment and activation of the intermingled PMNs.
Over the last decade, cytokine gene transfer strategies in animal models have provided a tool with which to dramatically increase intratumoral cytokine availability, avoid the side effects of systemic administrations, and evaluate the antineoplastic potential of locally recruited PMNs.
Cytokines at the tumor site
The natural tumor-PMN balance can be markedly altered by engineering tumors to release interleukins20 or chemokines21 in their microenvironment. Although the amount released is usually small, it may be gigantic when compared with wild-type tumors and produce dramatic effects.
Almost all the cytokines sustainedly released by engineered tumor cells, namely interleukin-1 (IL-1), IL-2, IL-3, IL-4, IL-7, IL-10, IL-12, interferon-α (IFN-α), IFN-β, IFN-γ, granulocyte-colony stimulating factor (G-CSF), and tumor necrosis factor-α (TNF-α),22,23 quickly recruit a massive local reaction that leads to the rejection of engineered tumor cells and the establishment of a significant immunity against the wild-type parental tumor. PMNs play a key role in all of these cytokine-induced tumor rejections, often in cooperation with CD8+ T lymphocytes.23 As circulating granulocytes of tumor patients have impaired cytotoxic activity,24 which is further decreased by most chemotherapeutic agents,25 the elaboration of systems capable of guiding the recruitment of PMNs and their activation within a tumor microenvironment can be put forward as a fresh therapeutic approach.
PMN recruitment into the tumor
Extravasation from the blood into a tumor is a regulated multistep process involving a series of coordinated interactions between PMNs and endothelial cells.26 Several molecular regulator families, namely selectins, integrins, and cytokines, are thought to control the steps of this process. It is well known that P-, E-, and L-selectin adhesion molecules (also known as GMP 140, ELAM-1, and LAM-1, respectively) initially tether free-flowing neutrophils to the endothelium of postcapillary venules and mediate transient interactions by causing them to roll much more slowly. Slowly progressing PMNs pick up the signals delivered by interleukins, chemokines, and other mediators released by the endothelium and become firmly attached to it via β2 integrin (MAC-1, ie, CD11b/CD18)–intercellular adhesion molecule-1 (ICAM-1) recognition.27 The endothelium is thus the most active controller of leukocyte traffic and behavior through its display of specific signals.
Some proinflammatory mediators or other factors directly secreted by engineered tumor cells, or elicited as downstream mediators by the released cytokine, increase the endothelial expression of several leukocyte adhesion and activation molecules. IL-1β and TNF-α induce and/or up-regulate ELAM-1, P-selectin, ICAM-1, and vascular cell adhesion molecule-1 expression in endothelial cells, whereas IFN-γ mainly promotes ICAM-1 expression.28-31 This cytokine-endothelium cross-talk is thus the first step in regulating PMN intratumoral accumulation (Figure 1).
PMN intratumoral accumulation is also attained when IL-10, a cytokine typically regarded as an anti-inflammatory mediator because it inhibits the release of other interleukins and chemokines,32-34 is present in the microenvironment. We have demonstrated that local release of high levels of IL-10 by IL-10 gene transfected mammary carcinoma cells (TSA–IL-10) in a syngeneic host results in both an anti- and a pro-inflammatory activity, through strong endothelial ELAM-1 expression in peripheral tumor microvessels.35 This expression and subsequent intratumoral accumulation of PMNs were directly attributable to IL-10, since no secondary mediators were detected.35,36 Moreover, it is likely that IL-10 attenuates the constitutive endothelial cell release of nitric oxide37 and contributes to the adhesion of PMNs to microvessels38,39 and their intratumoral accumulation.
It has been recently reported that IL-10 up-regulates the expression of the liver-expressed chemokine (LEC), a human β chemokine also known as NCC-4, HCC-4, and LMC.40 LEC is chemotactic for human monocytes and dendritic cells, but not for neutrophils.41,42 Nevertheless, local accumulation of LEC secreted by engineered TSA cells (TSA-LEC) quickly induces their rejection in association with an impressive recruitment of antigen- presenting cells, lymphocytes, and particularly PMNs.21
PMNs intratumorally recruited by highly expressed endothelial adhesion molecules also play a key role in mounting a strong antitumor response.21
Induction of ELAM-1 and up-regulation of ICAM-1 in the blood vessels, even in the case of tumors formed by cells engineered to release G-CSF, IL-2, IL-4, and IL-12, are attributable to both the cytokine-released and downstream-induced secondary mediators, such as CXC chemokines.43,44 Experiments with tumor cells transfected to release G-CSF, IL-2, and IL-12 as well as TNF-α,45-47 have disclosed an evident production of macrophage inflammatory protein-2 (MIP-2), also known as growth-related oncogene/cytokine–induced neutrophil chemoattractant (GRO/KC).48-50 This molecule is the murine functional homologue of human IL-8, which up-regulates the binding affinity of a family of adhesion molecules called integrins on PMNs and of its counter-receptor, ICAM-1, on endothelial cells.51Integrin-mediated adhesion leads to extravasation of PMNs highly attracted to the tumor site by MIP-2, which binds to the PMNs' CXCR1 or CXCR2 counterreceptor (see review in Luster52). MIP-2, together with other factors belonging to the IL-8 granulocyte chemoattractant family, is often released by tumor-associated macrophages under the stimulus of the cytokines released by tumor cells or the secondary mediators they induce.53 We found that macrophages and endothelial cells were clearly stained by anti–MIP-2 antibody when TNF-α as well as IL-1β were present in the tumor microenvironment.44,46 In all these cases, MIP-2 expression was associated with marked recruitment of PMNs, whose accumulation was further enhanced by the further release of MIP-2 produced by PMNs themselves in response to stimulation by TNF-α in the tumor microenvironment.
PMN-induced tumor destruction
Recruited PMNs produce several cytotoxic mediators, including reactive oxygen species, proteases, membrane-perforating agents, and soluble mediators of cell killing, such as TNF-α, IL-1β, and IFNs (Figure 1).
Oxidants employ 2 mechanisms to injure tumor cells. They act synergically with protease and other agents, and inactivate plasma antiproteases to allow proteases to operate.54
Recent dissection of the cytolytic armamentarium of PMNs has suggested a primary role for hypochlorous acid (HOCl) in mediating tumor cell lysis by activated PMNs after their leukocyte function–associated antigen 1–dependent recognition of the target cell surface.55 Furthermore, a distinct adhesion pathway, mediated by CD11b/CD18 up-regulation on activated PMNs, enables these cells to adhere to the vascular endothelium and create a subjacent microenvironment, allowing accumulation of oxidants and proteolytic enzymes at local concentrations sufficient to cause endothelial damage and matrix degradation.56 In addition, PMN-released HOCl reacts with primary amines to form relatively stable chloramines with immunostimulatory properties.57
Although reactive oxygen and reactive nitrogen intermediates are toxic molecules that contribute to the control of tumors, they also mediate inhibition of T-cell proliferation by suppressing macrophage functions. This mechanism accounts, at least in part, for the immunosuppressed state seen in certain infectious diseases, malignancies, and graft-versus-host reactions (see review in Bogdan et al58).
A further mechanism of PMN-mediated tumor cell killing is antibody-dependent cell-mediated cytotoxicity (ADCC).59The role of antibody-independent recognition of tumor cells by cytotoxic T cells has been extensively researched, whereas only a few recent works have shown that in vivo tumor ADCC also exists.60-63 Granulocyte-macrophage–CSF (GM-CSF) augments the normal PMN ADCC of melanoma, neuroblastoma, and colorectal cancer cells.64-66
Recent preclinical studies of the treatment of advanced renal cell carcinoma by combining bispecific antibodies (with one specificity against the epidermal growth factor–receptor (EGF-R) overexpressed on the majority of renal cell carcinomas, and another specificity against Fc receptors on human leukocytes) with G-CSF or GM-CSF therapy have demonstrated that granulocytes are the most active effector cell population.67 Although systemic application of bispecific antibodies is suitable at present only for adjuvant treatment of minimal residual disease due to poor tumor cell accessibility, local administration, either alone or in combination with autologous effector cells, is highly effective in eradicating tumor cells.68
In our murine model, IL-10–releasing TSA cells initially grow and are then rejected by the combined action of CD8+ lymphocytes, natural killer (NK) cells, and PMNs.35,69 As already mentioned, the marked anti-TSA antibody response that follows this rejection may be responsible for PMN-mediated tumor ADCC.
A markedly high titer of anti-TSA antibodies is also elicited during the early phases of LEC-releasing TSA tumor cell rejection. Here, too, antibodies may provide further guidance for the PMN-dependent tumor rejection.21
A family of antimicrobicidal peptides called defensins has been described in humans.70 Defensins are the most abundant component of the azurophil granules of PMNs and are highly toxic against several types of tumor cells.71
These granules also contain elastase and cathepsin G, 2 proteases particularly injurious to endothelial cells.72 It is still uncertain whether adhesion of PMNs to tumor cells is required to cause injury. However, the ultrastructural studies performed during the growth and rejection phases of several tumors engineered to release cytokines show PMNs in close contact with injured tumor cells.23,47 An absolute need for adhesion cannot, of course, be inferred from observations of this kind.
Histological and ultrastructural investigation of tumor growth area morphology shows that the damage produced by PMNs takes 2 forms: predominantly colliquative necrosis when their cytotoxicity against tumor cells prevails23 and predominantly ischemic and/or hemorrhagic necrosis when their main target is the vascular endothelium.20,23,35,73,74
Modulation of PMN behavior by cytokines
Serial immunohistological examination and polymerase chain reaction analysis after a subcutaneous challenge with TSA–IL-2, TSA–IL-4, TSA–IL-10, TSA–IL-12, and TSA–TNF-α cells have shown that the local release of all these cytokines elicits a quick and effective PMN-mediated antitumor activity.20,44The kinetics, however, are not the same, and the boosted PMN functions are often different.
Presence of pro-inflammatory cytokines
Paracrine release of IL-2, IL-4, IL-12, and TNF-α induced prompt tumor rejection (Figure 2A) marked by the formation of areas of colliquative necrosis typically associated with a massive presence of degranulated PMNs with exocyted granules in close contact with tumor cells displaying ultrastructural signs of irreversible damage (Figure 2B). This indication of direct killing by PMNs was particularly evident in the presence of paracrine IL-2 and TNF-α.
Interestingly, the observed release of TNF-α into the circulation during infusional recombinant (r) IL-2 therapy of cancer patients is often associated with a potent activation of PMNs that interact with tumor cells and endothelial cells and cause their subsequent lysis.75,76 According to this killing activity, PMNs appear to mediate most of the therapeutic efficacy, but also the systemic toxicity of rIL-2 (ie, vascular leak syndrome).77However, these 2 opposite effects might converge in a single antitumor effect with the development of intratumoral cytokine gene transfer therapy.
In mice, direct killing by PMNs was also a hallmark of the rejection of tumor cells engineered to release G-CSF. Activated PMNs with prominent cytoplasmic projections, in fact, were observed in close contact with dead tumor cells47,78 well before any vascularization of injected tumors was possible. When recipient mice were sublethally irradiated, tumors grew and became vascularized before the rejection that occurred when PMNs and leukocytes were self-reconstituted. In this case, the tumor-associated blood vessels were the main PMN target.78
Immunohistological analysis showed that in all these situations IL-1β and TNF-α were the predominant downstream pro-inflammatory cytokines elicited in the tumor growth area. They were usually associated with MIP-2 expression in both tumor-associated macrophages and PMNs. Indeed, by thus inducing macrophages to produce PMN chemoattractants, they set up a vicious circle, since they also stimulate PMNs to produce MIP-2 and probably other factors belonging to the IL-8 granulocyte chemoattractant family (Figure 3).
The marked and rapid PMN influx and tumor necrosis observed in nude mice challenged with human tumor cells engineered to release IL-8 (the functional human equivalent of MIP-2), human MIP-1α, and murine MIP-1α79 show that both CXC chemokines, such as IL-8 and GROs, and specific CC chemokines, such as MIP-1α, regulate PMN traffic and functions, providing further evidence that recruited PMNs suppress tumor growth.
Absence of pro-inflammatory cytokines
Rejection of TSA–IL-10 cells, on the other hand, is paradigmatically different.
By suppressing the release of pro-inflammatory cytokines such as IL-1β, TNF-α, and GM-CSF, paracrine IL-10 impairs the early influx of PMNs and permits initial tumor formation by transiently paralyzing a prompt nonspecific antitumor response.35,69 However, by directly acting on endothelial cells, it induces adhesion molecules and attenuates their nitric oxide release, thus favoring leukocyte recruitment in vivo.36,80,81 Leukocytes and mainly neutrophils are responsible for the intratumoral microvasculature damage that results in multiple ischemic necrotic areas.
Local necrosis is followed by massive infiltration by PMNs and a few T and NK cells, probably recruited by mediators induced by hypoxia and necrosis.82 The late influx of reactive cells, however, is enough to lead to complete rejection of the established tumor. This does not take place in the absence of PMNs.69
The well-known immunosuppressive activity demonstrated by IL-10 in vitro has naturally impeded assessment of its potential use in the treatment of solid human tumors. Its employment has been proposed only for management of the rare myeloproliferative disorder called juvenile myelomonocytic leukemia.83 Even here, consideration has been devoted solely to its ability to inhibit the production of cytokines and growth factors by myelomonocytes in vitro.83Animal data, however, suggest that intratumoral administration of IL-10 inhibits tumor growth through a pro-inflammatory activity in which PMNs again play a fundamental role.35,69
Presence of IFN-γ
The presence in the tumor growth area of appreciable amounts of IFN-γ together with IL-1β and TNF-α was noted after injection of TSA cells engineered to release IL-2, IL-4, and IL-12.43,44 It was even more evident when local or systemic administration of rIL-12 in mice bearing a subcutaneous 7-day-old TSA tumor resulted in intratumoral expression of the messenger RNA of IL-1β, TNF-α, and IFN-γ, together with IP-10 and MIG,44 2 chemokines with well-known antiangiogenic activities. IL-1β and TNF-α probably induced the production of PMN chemoattractants by tumor-associated macrophages, as the number of tumor-infiltrating PMNs was significantly enhanced after 3 intraperitoneal administrations of rIL-12.
The presence of IFN-γ as secondary mediator, however, must also have induced both macrophages and PMNs to produce IP-10 and MIG84,85 (Figure 3). The rapid influx of PMNs with a high destructive potential and an IP-10– and MIG-mediated anti-angiogenic function resulted in vascular damage, inhibition of angiogenesis, and extensive ischemic/hemorrhagic necrosis after 3 and 8 rIL-12 administrations. Macrophages were undoubtedly essential modulators of this immune response. The crucial importance of PMNs, however, was made clear when their selective depletion abolished the rIL-12–induced antitumor effect. Whether PMNs also have a role in IL-12 therapy of human cancer has still to be determined.
IP-10 and MIG are also intense chemoattractants for monocytes and T cells.86-88 They promote T-cell adhesion to endothelial cells and are leading recruiters of the T cells, particularly CD8+, found to be indispensable, like PMNs, for complete eradication of most of our inocula and experimental tumors.
The presence of IFN-γ and its induction of a cytokine cascade are usually associated with an elevated antitumor memory reaction, since all inocula with IFN-γ in the growth area led to the rejection of a secondary challenge (Figure 3).
PMNs and the antitumor immune memory
PMNs do not seem of great importance in the elaboration of a significant immune memory against the secondary tumor cell challenge. Even so, they are certainly one of the effector arms involved in the destruction of a second inoculum that takes place once this memory is established. This was particularly evident in the case of TSA cells transfected with the IFN-γ gene.20,23 This tumor, in which the PMN infiltrate is almost absent, was rejected in only 25% of cases, though the immune memory established after the first challenge always provided complete protection against a subsequent TSA–parental cell inoculum.
Provided there is IFN-γ in the tumor growth area, the cytokine released by the engineered tumor cells plays a significant role in skewing the memory reaction toward TH1 and TH2. However, secondary rejection is not simply the work of T cells. Massive PMN recruitment, in fact, is consistently evident in both TH1- and TH2-deflected memories. Since their selective removal impairs or even abolishes rejection after establishment of the immune memory,21,69,89 it may well be that PMNs play hitherto unsuspected roles.
PMN-mediated ADCC may significantly contribute to the immune memory leading to secondary tumor cell rejection.59,64,65However, there may be a more complex interplay in which T cells release a guidance factor that directs the powerful destructive action of PMNs. Close contacts between granulocytes, lymphocytes, and tumor cells are typical of immune memory reactions, in keeping with the possibility that cytolytic activity of granulocytes is guided by factors secreted by lymphocytes.
PMNs and anticancer therapy in humans
New, interesting perspectives are opening to exploit PMN functions for anticancer strategies in patients.
During therapy with G-CSF, significantly enhanced in vitro cytotoxicity of isolated PMNs against glioblastoma, squamous cell, ovarian, and breast carcinoma cells was observed with sensitizing monoclonal antibody to the oncogene products EGF-R and HER-2/neu.90-92
Indeed, a phase I study in patients with breast and ovarian cancer showed that biological and clinical activities at well-tolerated doses of bispecific antibodies to FcRI selectively induced on neutrophils and HER-2/neu expressed on tumor target cells.91,92
In hematologic malignancies, where tumor cells are relatively accessible to antibodies and effector cells, malignant B cells displayed a particularly high susceptibility to neutrophil-mediated ADCC.93
Phenotypic and functional evidence of potent PMN activation has also been observed during rIL-2 infusion in patients with advanced malignant melanoma and renal cell carcinoma.94,95 Furthermore, patients showing disease response to treatment have a significantly greater production of PMN oxidants, such as HOCl, which is regarded as instrumental in tumor cell lysis.55,77
Evidence suggests that production of the tumoricidal long-lived oxidant HOCl, along with up-regulation of PMN surface integrins, may also contribute to the antineoplastic efficacy of infusional therapy with TNF-α.96-98
However, besides their involvement in the therapeutic efficacy of certain cytokines, PMNs may be partly responsible for the toxic side effects of high-dose systemic cytokine therapy.77
The poor results obtained in humans with systemic cytokine therapy have cast a shadow over this type of approach, especially since its failures were ascribable mainly to multiple side effects and enrollment in phase I trials of patients with advanced disease and a deeply compromised immune system. The extremely encouraging results obtained with local intratumoral cytokine release in animal models, on the other hand, suggest the possibility of successful antitumor management through an improvement in cytokine gene therapy biotechnology and procedures for patients with a reasonable immunological performance and low tumor load or minimal residual disease.
It is clear, in any event, that in addition to being the body's main defenders against infection and foreign invaders, PMNs could be a perfect weapon for the suppression of tumor growth and tumor rejection in T-cell memory reactions, while their ability to respond to and produce cytokines2,3 involves them in the cross-talk between tumor cells and the endothelium and between nonspecific and specific immune cells.5
A deeper insight into the biological role of immunoregulatory molecules acting as cytokines that stimulate specific PMN functions may thus lead to the elaboration of a new approach to the treatment of cancer.
We thank Dr John Iliffe for critical review of the manuscript.
Supported by grants from the Italian Association for Cancer Research (AIRC); the Istituto Superiore di Sanità Special Programs of Gene Therapy and Antitumor Therapy; C.N.R. Target Project on Biotechnology; MURST 40% and cluster 03—Molecular Engineering—funds, and the US Department of the Army grant DAMD 17-98-1-8030 (G.F.); and by a fellowship from the Italian Foundation for Cancer Research (E.D.C.).
The publication costs of this article were defrayed in part by page charge payment. Therefore, and solely to indicate this fact, this article is hereby marked "advertisement" in accordance with 18 U.S.C. section 1734.
Author notes
Piero Musiani, G. d' Annunzio University of Chieti, Anatomia Patologica, Osp. SS. Annunziata, Via Valignani, 66100 Chieti, Italy; e-mail: firstname.lastname@example.com.


text:
What it does:
What it is:
If you're starting to notice the initial signs of aging on your skin and are looking for a way to successfully diminish them, consider this carefully-curated set as your newest secret weapon! This kit consists of six high-quality anti-aging products that will help people in their thirties prevent the appearance of wrinkles, roughness, and age spots.
Each product is focused on targeting age-related skin changes and slows down the aging process of your skin. Its anti-aging properties help improve the skin's appearance by enhancing its moisture content while eliminating the damaging free radicals.
How it's made:


text:
"She's not necessarily my image. I was asked to dress her quite a few years ago. I declined," Ford said. The designer, who voted for Hillary Clinton, noted that it wasn't necessarily Melania so much as her position as the first lady that factored into his decision.
"Even had Hillary won, she shouldn't be wearing my clothes. They're too expensive. And I don't mean that in a bad way '" they're not artificially expensive, it's the cost to make these things." When asked if Melania should stay away from expensive pieces, he added, "I'm going to leave that to Melania."


text:
Rob Nuckolls
Rob Nuckolls has been playing and coaching soccer for more than 30 years.
Coach Rob and his wife Michelle have 2 kids. Away from the game, they enjoy vacationing, anywhere with a beach and sun.
Rob holds a USSF National "C" License and is a Michigan Olympic Development Program CoachEmail:Cell: 810-955-3364
Kenny Uzoigwe
Director of Player Development , Head Coach
Kenny Uzoigwe is the Celtic Director of Player Development. He is a former MLS player with the Colorado Rapids and is a Hall of Famer with the Michigan Bucks as well as a Head Coach for the Celtic Soccer Club.
Coach Kenny lists spending time with his family and vacationing as his off the field passions.
Kenny holds a Coerver Youth Diploma and USSF National "C" LicenseEmail:Cell: 248-481-1044
Steve Applebee
Head Coach , Vice-President
Steve Applebee has been playing and coaching soccer for more than 30 years.
Steve and his wife Aimee have two kids Olivia and Owen.
Steve holds a USSF "D" LicenseEmail:Cell: 810-444-6079
Doug BurroughsBoard of Directors , Director of Coaching , Head Coach
Doug Burroughs is a member of the Board of Directors, Director of Coaching and a Head Coach for the Genesee Celtic Soccer Club.
As a Grand Blanc Hall of Fame coach, Doug won 20 Big Nine championships, 11 district titles and 5 regional championships.
When he's not coaching, Doug loves working in the yard, hiking through the woods, spending time with friends and family.
Doug holds a USSF National "B" LicenseEmail:Cell: 810-423-7686
Derek FeltBoard of Directors, Head Coach
Derek is a lifelong resident of Grand Blanc and grew up playing for the old Flint Arrows as a youth before taking his game to Michigan State University.
Derek holds a USSF LicenseEmail:Cell: 810-516-3285
Geoffrey Gale
Goalie Coach
Geoffrey is married and a lifelong resident of the Genesee County area. He has played and coached the game since the mid 1970's. One of his favorite hobbies off the field is fishing and spending time on the lake.
Geoff holds a USSF LicenseEmail:Cell: 810-569-5406
Bryce Miller
A self described "student of the game," Bryce has basically grown up on the soccer fields. His love for the game and his passion for teaching is what motivates him on a daily basis.
Bryce holds a USSF LicenseEmail:Cell: 810-569-1616
Josh Jones
Head CoachJosh is a graduate of Grand Blanc high school. He played soccer at Grand Blanc and was named captain of the varsity his senior year. When he's not on the pitch, Josh can be found practicing law in the metro Detroit area as a criminal defense attorney.
Josh holds a USSF National LicenseEmail:Cell: 810-691-7308
Norman Power
Head Coach
Norman grew up playing in Ireland where he won several national championships with De La Salle in Ballyfermot, Dublin and was on the U15 and 16 national team before going professional. He was on trial with Middlesbrough F.C. at the age of 15 before signing with Saint Patrick F.C. (Dublin) and then Shelbourne F.C. (Dublin). He received a full ride to Clemson University and then transferred to CSU (Charleston Southern University. Norman holds a USSF "A" license, and National Youth Diploma and has been on staff with ODP since 1997. He has coached at all levels, here and abroad, from youth to collegiate. In addition, Norman is trilingual in English, Irish (Gaelic) and French.Email:Cell: 517-599-2549
Christian Pumphrey
Head CoachChristian holds a USSF LicenseEmail:Cell: 810-444-9324Will TuckerPhoto coming soonWill holds a USSF LicenseEmail:Cell: 810-618-2221
PO Box 1157 Grand Blanc, Michigan 48480
Phone: 810-955-3364


text:
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Travel, Surf and Living Right
From the Journeys of Austin Sonnier Go I strive for the feeling I receive when I leap and bound, with no notion of small waning steps, far outside my comfort zone. I feel more calm and at ease in a chaos abroad than in the congested streets of our domestic cityscapes. When mentioning chaos I do not mean danger and violence, immediate peril or destruction. I mean the chaos of life, a living essence uncontrolled and striped. Pure. Naked. Where the ticks and tocks of all society's clocks are silenced, nude. Here, a series of trees and an untamed breeze,...
SanO at the Mexi Log Fest 2016
Team Slider Austin is down in Sayulita for the Mexi Log Fest 2016. We look forward to hearing about his adventures and wishing him all the best in his heats. His first heat is at 8:35, Friday morning. He is well equipped with a brand new sled shape by Josh Martin.
SanO X Hobie Surf Shop
One of our favorite ads of the year in collaboration with Hobie. Check out the Fall 2015 issue of Stay Wild Magazine.
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|.industries domains
next update in 15 hours
|4 956
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.industries is a generic top-level domains (gTLDs) zone registry by Binky Moon.
We have 4 956 domains available in .industries zone on 28 November 2020.
The list includes domain + emails of domain owners that have been registered in the last day. E-mails are collected from publicly available information and analyzed.
The file contains the most complete list of all registered domains from .industries zone. You can download a list of all .industries Internet addresses with one file in one click. Each domain is a separate line in the file. We update the data in the file every day. Data is also available through API.


text:
It only started with a simple 'hello'
Then things changed between us two
You said 'I love you', I said ' I do'
And it went on to be so true.
You cared for me and made me smile
Made me happy everyday and every while
You always proved that you were sincere
Yes, you were, it was very clear.
Everything went fine as months passed by
But then suddenly I began to cry
'Cause you're gone, I wanted to die
Yes, your love for me was only a lie.
I'm afraid I can't let you go
But it's the thing that I should do
It's much pain still holding on to you
The love we had just can't be true.
A big world's still ahead of me
And I must go on so I can see
The love that's real and meant for me
And you are just a mistaken ecstasy.
On a Cold, Lonely Night coming soon!Report Reply
thnx for appreciating, yoonoos..you think it's too childish? ?Report Reply
nice piece don!
This poem has not been translated into any other language yet.
I would like to translate this poem »


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NO PREVIOUS EXPERIENCE REQUIREDAre you physically fit with your own steel toed work shoes and reflective vest?Manpower has an immediate opening for Warehouse associate (essential work) with our client located in Vancouver, (5 Min walk from Rupert station) Shift start time:7 days a week: 730am(6 to 8 hour shift) FULL TIME ASSOCIATES WILL HAVE PREFERENCE in the morning shift.4pm (3 to 5 hours shift) part timers can complete their 20hs in the afternoon shift. Depending on volume Rate of pay: $17 an hour What is in it for you?- Weekly pay- Start immediately- Safe working environment- Opportunity for permanent full-time work- Transit accessible (right by Rupert skytrain station) What is the job?- Lifting up to 55 lbs = 25 kg- Scanning and moving boxes- Following all safety procedures- Attention to detail What you bring to the job?- A strong work ethic- Must be physically fit- Steel toed work boots and reflective vest required- Team player attitude- Basic English is okIf you are available for immediate start please apply now!!!Stop your job search and apply today for this full time position. Select APPLY NOW to hear from our recruiters within 24 hours. We love referrals so please share our jobs with your friends and family to qualify for our $100 referral bonus! Be sure to check out Manpower's career platform with tools and resources to prepare you for today and tomorrow's jobs at www.manpower.com/mypath
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1-7-2020 - Federal student loan debt now tops $1.5 trillion according to a report released last week by the Federal Student Aid office of the U.S. Department of Education. This is a huge debt bubble that will only grow larger, with approximately 16.1 million new student loan applications already being processed for the 2019-2020 loan cycle. Student loan repayments have become a major burden on college graduates as college costs continue to skyrocket.
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Tuesday, January 7, 2020
News Byte: Student Loan Debt Tops $1.5 Trillion
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By Steven Rosenbaum
Company Leaders Are humming approximately Curation country "An indispensible advisor to the courageous new media world." —Arianna Huffington, editor in leader, the Huffington submit "Gives me desire for the way forward for the data Age. Rosenbaum argues for the transforming into significance of people—creative, shrewdpermanent, hip—who can spot traits, locate styles, and make that means out of the flood of knowledge that threatens to weigh down us." —Daniel H. purple, manhattan instances bestselling writer of force "A testomony to the strategic brain of a genius and a street map for constructing enticing patron stories by means of curating content material round your brand." —Bonin Bough, international Director, electronic and Social Media, PepsiCo "Perfectly on-trend—an insightful consultant to the long run. So pleasing you won't placed it down."—Chris Meyer, writer of Blur "Read this ebook. embody curation, and you'll be capable to 'crush it' with concentration and fervour within the noisy new global of big info overload." —Gary Vaynerchuk, long island occasions bestselling writer of overwhelm It "Provides a wealth of real-world examples of ways companies can use the net to offer their consumers a invaluable curated experience." —Tony Hsieh, CEO, Zappos.com, and ny instances bestselling writer of providing Happiness "Our most sensible wish for sorting the great from the mediocre in our more and more overwhelming media landscape." —Clay Shirky, writer of Cognitive Surplus and right here Comes each person in regards to the publication: Let's face it, we're drowning in facts. Our inboxes are flooded with unsolicited mail, we have now too many "friends" on fb, and our Twitter debts became downright unmanageable. developing content material is simple; discovering what concerns is tough. thankfully, there's a new magic that makes the internet paintings. It's referred to as curation, and it allows humans to kind throughout the electronic extra and locate what's correct. In Curation country, Steven Rosenbaum unearths why manufacturers, publishers, and content material marketers needs to embody aggregation and curation to develop an latest enterprise or release a brand new one. actually, he asserts that curation is the single solution to be aggressive sooner or later. beaten through an excessive amount of content material, individuals are hungry for an adventure that either takes good thing about the Web's breadth and intensity and gives a degree of human sorting and filtering that se's easily can't in attaining. In those transferring sands lies a rare company chance: you could develop into a depended on resource of worth in an another way meaningless chaos of electronic noise. In Curation state, Rosenbaum "curates the curators" via amassing jointly valuable perception and recommendation from the head thinkers in media, advertisements, publishing, trade, and net applied sciences. This groundbreaking publication degrees the enjoying box, giving your small business equivalent entry to the content material abundance shortly riding customer adoption of the internet. because the sheer quantity of electronic info on the earth raises, the call for for caliber and context turns into extra pressing. Curation will quickly join what you are promoting and your electronic international. comprehend it now, take part early, and acquire the various merits Curation country has to supply. study extra at CurationNation.org.
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S. companies use outsourced labor, a figure that has grown from 6 percent to more than 27 percent since 1990. The freelance nation even has people with full-time jobs looking for ways to turn their passions, knowledge, or skills into a revenue stream. The result is the emergence of the pro-sumer, a consumer turned part-time professional. What makes this model so powerful is that it allows a new class of curators to emerge who are in many ways more deeply committed to their narrow fields of interest.
And second, there is both amateur and professional curation, and the emergence of amateur or pro-sumer curators isn't in any way a threat to professionals. Curation is very much the core shift in commerce, editorial, and communities that require highly qualified humans. Humans aren't extra, or special, or enhancements; humans are curators. They do what no computer can possibly achieve. There's far too much nuance in human tribes and the taste of groups and individuals. Curation is about selection, organization, presentation, and evolution.
Now in Curation Nation, he's sharing that gift with the rest of us. Don't miss out. " —Alan M. " —Andrew Heyward, former president, CBS News; principal, MarketspaceNext "To make sense of our information flood, we need to combine human and machine intelligence. " —Jeff Hayzlett, author, The Mirror Test "Of all the power shifts that are redefining the competitive environment, none matters more than the rise of readers, users, and customers as the true power players in business and media. Steven Rosenbaum understands how to do great things in this new environment, and in Curation Nation he explains his ideas and makes them come to life.


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Study: Virus cases must drop for state's schools to safely reopen
Bringing students back in any capacity will lead to new infections, the report found.
Heat wave is on the way this weekend
Temperatures are expected to climb into the mid-90s on Sunday.
Downtown Streatery here to stay through September
After a short pause, Issaquah has reopened the street outdoor dining in downtown.
School district distributes thousands of extra meals amid pandemic
Congress hasn't renewed the program, which provided twice as many student meals for free last spring.
Inslee lifts visitation ban at long-term care facilities
Starting Wednesday, a four-phase plan will allow restrictions at nursing homes to gradually be relaxed.
Inslee says schools in virus hot spots should stay closed
King County among high-risk counties; several school districts will have remote learning in the fall.
Inslee and Culp lead governor race; incumbent Dems ahead for Congress | Statewide results
Early results for governor, state schools chief, attorney general and more.
Democrats dominate King County legislative races | Election results
Here are the latest results for King County legislative candidates in the Aug. 4 primary election, which included races for the state House and state… Continue reading
5th District results: Ramos leads House race; Anderson edging Mullett for state Senate
Early results have been reported in the 5th Legislative District races from the Aug. 4 primary election. This summer's election for the Washington state Legislature… Continue reading
Still time to vote in August primary
Turn in your ballot at any voting center by 8 p.m.
Did Republicans give up on the 5th District?
The sole Republican candidate has raised only $3,100.
Free mask event for King County residents, Aug. 4 in Bellevue
The drive-thru distribution event will offer two masks per person
Primary election 2020: Who will emerge as Inslee's challenger?
Voting ends Tuesday in an election without big rallies and fund-raisers and face-to-face debates
Sex ed, local control at heart of race for WA state schools chief
Incumbent Chris Reykdal faces five foes who argue he's pushing too many state policies on school districts.
Issaquah Superintendent announces fully remote start to fall classes
The recommendation will be presented at the school board meeting Thursday
County Fire Marshal issues burn ban
Dry conditions and high heats are in the forecast this week
COVID-19 cases and deaths in King County cities
Numbers as of July 23, 2020.
Governor tightens restrictions on restaurants, bars, weddings, funerals
Staff reports Washington Gov. Jay Inslee said Thursday (July 23) he is tightening restrictions throughout the state for restaurants, bars, weddings, funerals and gyms in… Continue reading
Abortions could stop at Virginia Mason if merger is approved, reproductive rights advocates say
Hospital representatives said "certain services" would cease, but wouldn't give specifics.
Do opportunity zones in King County work?
The zones were created by Congress in 2017 to create jobs and spur economic development.


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Chapter 449 - Hard Resistance!
Vampires were a type of powerful creatures.
Higher level Vampires were creatures that could compete with Liches. They were born with the ability to [Dominate Humans]; they could [Alter Self] into bats, gases, monsters, etc.; and could [Drain Energy] and reduced the enemy's professional level by two when attacking. Their inborn racial characteristics enabled them to have a high [Damage Reduction] ability. At the same time, their claws and teeth were regarded as [Natural Magic Weapons]. They had the properties of [Flash Heal], had the lowest level of [12 Points of Basic Health], and were the same level as the Barbarians, and they also had [Natural Additional Armor +6]. They were [Creature of the Night], they could [Create Spawn], and after transforming into Vampires, [Strength +6, Dexterity +4, Intelligence +2, Wisdom +2, Charm +4] and many more.
These did not amount to much!
The Demigod Vampire was still chased, slashing around like a dog by Soran. All his eroding abilities could be ignored in front of Soran's powerful immunity and resistance. Whatever [Dominate Humans], whatever [Drain Energy], whatever [Alter Self], whatever [Natural Magic Weapons], whatever [Flash Heal], whatever [Damage Reduction], Soran wielded the sword with both his hands like a whirlwind. No matter how high your damage reduction was, no matter how amazingly fast your regeneration ability was, as long as you were touched by the Holy Avenger, one could guarantee that within minutes, it would teach you to become a new man!
There was a saying that went —– "Amongst the world's martial arts, only the fast are not broken!"
Soran had no doubt that in the state of his own outburst at the moment, even if someone was crazily shooting at him with a machine gun, he could stop those bullets.
At last, he could understand the feeling during the War of Golems, where the legendary Sword Saint used his swords to block bullets while sprinting.
Although Soran chose the path of a Rogue, in fact, he has been influenced by many Sword Saints. He had the ultimate pursuit of a Sword Saint in his heart, but he did not have the belief of "Facing Death as Equanimity" like them. Only when he pursued both lethality and life preservation could Soran choose the way of a Rogue.
Maybe all the professionals in the melee specialization had been influenced by the Sword Saints.
After all, the existence of a Sword Saint itself was a benchmark!
With speed, strength, explosion, resistance, damage, and opportunity,
Soran had no doubt about it!
If he could not kill the Demigod Vampire today, it would be more difficult for him to kill the other party in the future. In this god-sent opportunity where he got a grade five artifact [Holy Avenger], and a group of Paladins nearby to help suppress the situation, he had to seize the day. He did not have to face the cannon fodder of the believers of the Vampiric Temple, and he did not have to worry about other people interfering with his fight.
——"Shadow Leap!"
——"Sword Form [Waist Chop]!"
Soran's use of the double wielding was fluid thanks to the Omnipotent Hands, which could allow him to use any weapon easily. More importantly, Soran's combat skills were very ferocious, and this kind of ferociousness depended on heavy weapons. Whether it was the Sword Form [Heavy Hack], Sword Form [Behead], Sword Form [Waist Chop], Sword Form [Spinning Strike] or any other combat skills, almost all of them were not able to be unleashed with small or light weapons.
Using two-handed weapons were much more invigorating than one-handed weapons!
Especially in the case of Sword Form [Waist Chop] and Sword Form [Behead], the Demigod Vampire did not even dare to undertake any of it.
The holy radiance was like fireworks, and the expression of the Demigod Vampire was more and more ferocious. At the end of the day, it has already become a frantic look. At this moment, he didn't look like the handsome noble he was once. Now he was in rags and looked like a dog that was so tragic. Because of anger and madness, his eyes turned red gradually, and his face turned into a pale, dark blue and gloomy terror. At last, the corners of his mouth revealed very obvious fangs. The outline of his face frame became much colder and crueler, and his chin was sharp. Dark black and green fingernails started to appear on his fingertips, and his skin seemed to have a metallic luster.
——"Vampire Form!"
Soran's second round of outburst finally enraged the Demigod Vampire, making him unable to maintain his handsome and elegant appearance, and revealing the true nature of the Vampire Form.
"Damn this guy! I will tear you into pieces! "
In the Vampire Form, Rhinehart's speed has increased significantly. His dark blue claws were covered with an unspeakable energy glow. If other Vampires had claws and fangs equivalent to 'Natural Magic Weapons', then as the Demigod Vampire, his claws must have reached the standard above legendary weapons.
As expected, the Demigod Vampire parried Soran's attack with his claws.
The collision of the two directly made a metallic sound, but it was obvious that there was a clear sword mark on the claws of the Demigod Vampire, and there were traces of burning holy energy on it. Although the recovery speed was very fast, the suppression effect of the Holy Avenger was still quite obvious. On the other hand, Soran, who was holding the Holy Avenger, had no problems at all. In a round of collision, Soran did not suffer any damage. However, the Demigod Vampire received 10 points of holy damage and 15 points of shadow erosion damage.
Shadow strikes would only take effect if it touched the enemy.
The damage did not fully work on the Demigod Vampire. The shielding effect of the Divine Energy Field was still there. The opponent was relying on the strong recovery ability to resist part of the damage, and the other part was transferred to the energy shield.
"I need to break his defense threshold!"
Soran's pupils slightly contracted, his entire body disappeared again on the spot, and the next moment the brightness of the Holy Avenger was like a whirlwind, sweeping directly to the Demigod Vampire in front of him.
It was obvious that the sound of breaking was heard, and the claws of the Demigod Vampire were broken into two by Soran.
The Divine Energy Field has weakened!
Soran's crazy attacks were constantly reducing the strength of the Divine Energy Field. As one of the most powerful weapons in the material plane, the Holy Avenger could cause nearly 100 points of damage at a time. Although the Demigod Vampire had the shielding of the Divine Energy Field, he has finally approached the brink of collapsing after withstanding so many attacks.
There was a trace of anxiety on the face of the Hellpoemer.
He did not know who the newcomer was, but he knew that this guy was very difficult to deal with. The Demigod Vampire was suppressed by him in his Avatar form. The Hellpoemer even doubted that he could not withstand several rounds of attacks. But even if he wanted to support the Demigod Vampire, he did not have any means to. The Warden in front of him was clinging him to death. No matter how he got the upper hand, it still could not be changed. That was the obvious advantage of a Paladin, and the Warden in front of him was also an old legendary who has been famous for hundreds of years.
The Hellpoemer has no doubt that the other party has the ability to restrain him, or even take the opportunity sneak an attack at the wounded Demigod Vampire.
But the fight could not go on like this.
He had to support the Demigod Vampire, or Rhinehart's defeat was only in a matter of time, and the sudden appearance of that madman seemed to have gone insane.
——"Fallen Praise [Legendary Warsong]!"
The Hellpoemer finally gave up relying on [Hell Song] to interfere and kill the enemy but chose to use [Fallen Praise] to strengthen the ability of the Demigod Vampire.
The odds of this battle were still in the air!
Although the Slaughterer was seriously injured by the Holy Avenger, its strength was still not able to be suppressed by ordinary Paladins. As long as the young Paladins could not hold up first, then the Slaughterer could get out of their control. At this time, the Hellpoemer's opportunity would arrive. As long as the Slaughterer interfered with the other party a little, he could rush over to help the Demigod Vampire to kill Soran!
Now, it depended on who could not hold on first!
It was either the group of young Paladins or the Demigod Vampire who was now completely suppressed by Soran.
For this, there was still a little faith in the heart of the Hellpoemer. No matter how tragic Rhinehart was suppressed into, he should be able to last longer than those Paladins, right?
The situation of the Paladins was really bad.
In fact, their casualties have already been very serious. In the beginning, they were attacked by the Demigod Vampire and the Hellpoemer, and they have lost their forerunners. Later, they were affected by "Time Stop." Several people were either directly killed or seriously injured. If Soran did not show up at that time, perhaps they would have been wiped out. But now, although Soran suppressed the Demigod Vampire and affected the situation of the battle, their situation did not get much better.
The Warden still had to hold back the Hellpoemer
Although the remaining young Paladins were all above the high grades, they still had to hold back the Deformed Demon, who was seriously injured but yet appeared even crazier!
It was hard to hold back this horrifying monster.
How could they hold it back?
Almost all the surviving young Paladins were risking their lives to hold it back!
One of the figures was so striking. He was wearing mottled silver-white armor, standing in the front of the first line, strongly resisting the Slaughterer. The breath of wind and frost made his face look a little tender, revealing a vicissitude of life. His injuries were actually very serious. The red blood drops flowed down his fingertips, but he still did not step back.
Because he could not!
In this case, if he retreated, everyone would die here!
Blood, fatigue, pain.
He had already unconsciously started to get used to these things. From the moment he left the City of Wealth, he walked thousands of miles, slept in the open, and saw too many things he could not imagine in the past. He had once fallen and lost his way, but he found his faith again. At last, he understood why there was always a trace of sadness in the eyes of the elder Paladins, because his heart had also begun to be filled with sadness!
He did not lose himself, nor was he fallen, his faith was firmer; his will was as strong as steel!
But, his heart was still filled with sorrow. He did not give up justice. He just did not know what was wrong with the world…..


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