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Rich Wood Look Tile Flooring
- By Sean Bonini
- on July 26, 2018
Believe it or not this flooring is not hardwood, it is actually wood tile! This beautiful tile is imported from Italy and is one of the higher end wood look porcelain tiles. We laid it with 1/8″ grout lines...Read more

subset: commoncrawl


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text:
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text:
Research By Markets adds Market Research Report - Latest Report On Canada General Surgery Market Outlook to 2025 – Access Instruments, Aesthetic Devices, Aesthetic Lasers and Energy Devices and Others
For detailed information: https://www.researchbymarkets.com/report/canada-general-surgery-market-outlook-to-2025-access-instruments-aesthetic-devices-aesthetic-lasers-and-energy-devices-and-others-657334.html
Canada General Surgery Market Outlook to 2025 – Access Instruments, Aesthetic Devices, Aesthetic Lasers and Energy Devices and Others
"Canada General Surgery Market Outlook to 2025" is a comprehensive databook report, covering key market data on the Canada General Surgery market. The databook report provides value (USD), volume (units) and average prices (USD) within market segments – Access Instruments, Aesthetic Devices, Aesthetic Lasers and Energy Devices, Bariatric Surgery Devices, Biopsy Devices, Bronchoscopes, Chest Drainage Catheters and Units, Colonoscopes, Cystoscopes, Duodenoscopes, Embolization Particles, Endoscopy Fluid Management Systems, Endoscopy Visualization Systems and Components, Esophagoscopes & Gastroscopes, Gynecological Devices, Hernia Repair Devices, Hysteroscopes, Laparoscopes, Laryngoscope Blades & Handles, Laryngoscopes, Non-Vascular Stents, Resectoscopes, Robotic Surgery, Sigmoidoscopes, Sterilization Equipment, Surgical Energy Devices, Surgical Stapling Devices and Ureteroscopes.
The Canada General Surgery Market report provides key information and data on –
– Annualized market revenues (USD), volume (units) and average prices (USD) data for each of the market segments. Data is provided from 2015 to 2025.
– 2019 company share and distribution share data for General Surgery Market.
– Global corporate-level profiles of key companies operating within the Canada General Surgery Market. Based on the availability of data for the particular category and country, information related to pipeline products, news and deals is also available in the report.
Canada General Surgery is segmented as follows –
– Access Instruments
– Aesthetic Devices
– Aesthetic Lasers and Energy Devices
– Bariatric Surgery Devices
– Biopsy Devices
– Bronchoscopes
– Chest Drainage Catheters and Units
– Colonoscopes
– Cystoscopes
– Duodenoscopes
– Embolization Particles
– Endoscopy Fluid Management Systems
– Endoscopy Visualization Systems and Components
– Esophagoscopes & Gastroscopes
– Gynecological Devices
– Hernia Repair Devices
– Hysteroscopes
– Laparoscopes
– Laryngoscope Blades & Handles
– Laryngoscopes
– Non-Vascular Stents
– Resectoscopes
– Robotic Surgery
– Sigmoidoscopes
– Sterilization Equipment
– Surgical Energy Devices
– Surgical Stapling Devices
– Ureteroscopes
Reasons to Buy
The Canada General Surgery Market report helps you to develop –
– Business strategies by identifying the key market segments poised for strong growth in the future.
– Market-entry and market expansion strategies.
– Design competition strategies by identifying who-stands-where in the market.
– Develop investment strategies by identifying the key market segments expected to register strong growth in the near future.
– Understand the key distribution channels and what's the most preferred mode of product distribution – Identify, understand and capitalize.
Companies Mentioned:
Olympus Corp
KARL STORZ SE & Co KG
PENTAX Medical Co
For queries regarding this report: https://www.researchbymarkets.com/sample-request/657334
Contact Us:
Sales Desk
Follow us on Social Media:
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text:
Document Type
Research Poster
Publication Date
Hip fractures occur approximately in 300K individuals aged 65+ annually post-fall
53.3% will sustain another fall; Mortality rate > 25%
The sit-to-stand (STS) task is impacted by hip fractures.
vGRF asymmetry with STS post-hip fracture (Houck et al.)
Hip fracture side < non-fractured side
Asymmetry not fully explained by LE strength in hip fracture nor CVA
Recommended Citation
Bui, Natash; Carlson, Andrew; Hepner, Caitie; Logan, Ashlyn; Munnell, Travis; Reordan, Bret; and Meszaros, Andrew J., "Sit-to-Stand Symmetry in Individuals with Hip Pathology" (2016). Student-Faculty Research - School of Physical Therapy. 41.


text:
Lost Fishermen's Memorial Planned for Lubec, ME
April 8, 2015
Ellesworth American: After nearly 6 years of fundraising, the Lost Fisherman's Memorial Association will soon break ground on its planned memorial.
Since 2009, the association has raised $120,000 for the planned Lubec sculpture. Not coincidentally, 2009 was a year when several area fishermen were lost at sea. Steuben sculptor Jesse Salsbury is going to begin working on the sculpture once the snow melts.
Read more about the Lost Fishermen's Memorial planned for Lubec, Maine.


text:
Prisoners – and the children of prisoners in public custody – are at "real risk" of psychological decline if severe pandemic lockdown measures are reintroduced in prisons, the prison watchdog has warned.
The roll-out of "virtual" technology – such as Zoom and Skype – that is now commonplace across workplaces is also yet to be typical in prisons but could help to improve inmates' mental health.
Peter Clarke, the Chief Inspector of Prisons, said that if there is a resurgence of the virus, the Prison Service should not simply reimpose the strict limitations it did when "lockdown" was ordered across the country as a whole.
Doing so could led to a serious decline in the mental health of a broad spectrum of prisoners in different settings, he said.
Clarke's comments – in an official report – follow the publication this week of Office for National Statistics figures which show that one in five individuals across the wider country as a whole has suffered some form of depression during the pandemic lockdown.
Concerns across prisons led to a strict regime which saw prisoners spend increased time in cells, segregation and a ban on all visits.
Public health officials have said they will need to remain in place until April next year.
The Prison Service is trying to move into a phase which will see those restrictions relaxed in a "slow and incremental" way.
But publishing a review on prison visits during the pandemic, Clarke said: "In prisons, there is now a real risk of psychological decline among prisoners, which needs to be addressed urgently, so that prisoners, children and detainees do not suffer long-term damage to their mental health and wellbeing, and prisons can fulfil their rehabilitative goals."
Prisons should do more to give prisoners access to technological solutions that could give them more access to "virtual visits" and "virtual" attendance on funerals of loved ones taking place outside of prison.
The issues are especially pressing fo children in public sector custody, who have lost access to special services and face-to-face education, and for some exceptionally vulnerable individuals in women's prisons.


text:
- Name
- Lenalidomide
- Accession Number
- Description
Lenalidomide (initially known as CC-5013 and marketed as Revlimid® by Celgene) is a derivative of thalidomide introduced in 2004. It was initially intended as a treatment for multiple myeloma, for which thalidomide is an accepted therapeutic modality, but has also shown efficacy in the hematological disorders known as the myelodysplastic syndromes. FDA approved on December 27, 2005.
- Type
- Small Molecule
- Groups
- Approved
- Structure
- Weight
- Average: 259.2606
Monoisotopic: 259.095691297
- Chemical Formula
- Synonyms
- 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
- 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Lenalidomida
- Lenalidomide
- External IDs
- Indication
Lenalidomide is indicated for the treatment of multiple myeloma in combination with dexamethasone. It is also indicated for the treatment of patients with transfusion-dependent anemia due to low- or intermediate- risk myelodysplastic syndromes (MDS) associated with a deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities.
- Associated Conditions
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.Learn More
- Pharmacodynamics
Lenalidomide, a thalidomide analogue, is an immunomodulatory agent possessing immunomodulatory and antiangiogenic properties. Lenalidomide inhibits the secretion of pro-inflammatory cytokines and increases the secretion of anti-inflammatory cytokines from peripheral blood mononuclear cells. Lenalidomide inhibits cell proliferation with varying effectiveness (IC50s) in some but not all cell lines. Lenalidomide is effective in inhibiting growth of Namalwa cells (a human B cell lymphoma cell line with a deletion of one chromosome 5) but is much less effective in inhibiting growth of KG-1 cells (human myeloblastic cell line, also with a deletion of one chromosome 5) and other cell lines without chromosome 5 deletions. Lenalidomide does not prolong the QTc interval.
- Mechanism of action
The mechanism of action of lenalidomide remains to be fully characterized, however it has been demonstrated that lenalidomide inhibits the expression of cyclooxygenase-2 (COX-2), but not COX-1, in vitro. In vivo it induces tumor cell apoptosis directly and indirectly by inhibition of bone marrow stromal cell support, by anti-angiogenic and anti-osteoclastogenic effects, and by immunomodulatory activity
Target Actions Organism AProtein cerebloninhibitor Humans ATumor necrosis factor ligand superfamily member 11inhibitor Humans UCadherin-5antagonist Humans UProstaglandin G/H synthase 2negative modulator Humans
- Absorption
Rapidly absorbed following oral administration, with maximum plasma concentrations occurring between 0.625 and 1.5 hours post-dose. Co-administration with food does not alter the extent of absorption (AUC) but does reduce the maximal plasma concentration (Cmax) by 36%. The pharmacokinetic disposition of lenalidomide is linear. Accumulation does not occur following multiple doses.
- Volume of distribution
- Not Available
- Protein binding
30% protein bound.
- Metabolism
Lenalidomide undergoes limited metabolism. Unchanged lenalidomide is the predominant circulating component in humans. Two identified metabolites are hydroxy-lenalidomide and N-acetyl-lenalidomide; each constitutes less than 5% of parent levels in circulation. The cytochrome P450 enzyme system is not involved with the metabolism of lenalidomide.
- Route of elimination
Elimination is primarily renal. When a single oral dose of 25 mg is given healthy subjects, 90% and 4% of the dose is eliminated in urine and feces, respectively. Hydroxy-lenalidomide and N-acetyl-lenalidomide represent 4.59% and 1.83% of the excreted dose, respectively.
- Half-life
Healthy subjects = 3 hours; Multiple myeloma or MDS patients = 3 - 5 hours.
- Clearance
The renal clearance of lenalidomide exceeds the glomerular filtration rate.
- Adverse Effects
Learn about our commercial Adverse Effects data.Learn More
- Toxicity
The most frequently reported adverse events were related to blood and lymphatic system disorders, skin and subcutaneous tissue disorders, gastrointestinal disorders, and general disorders and administrative site conditions.
- Affected organisms
- Humans and other mammals
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug InteractionUnlock Additional Data Abacavir Lenalidomide may decrease the excretion rate of Abacavir which could result in a higher serum level. Abatacept The risk or severity of adverse effects can be increased when Lenalidomide is combined with Abatacept. Abciximab The risk or severity of bleeding can be increased when Abciximab is combined with Lenalidomide. Acarbose Acarbose may decrease the excretion rate of Lenalidomide which could result in a higher serum level. Aceclofenac Aceclofenac may decrease the excretion rate of Lenalidomide which could result in a higher serum level. Acemetacin Acemetacin may decrease the excretion rate of Lenalidomide which could result in a higher serum level. Acenocoumarol The risk or severity of bleeding can be increased when Acenocoumarol is combined with Lenalidomide. Acetaminophen Acetaminophen may decrease the excretion rate of Lenalidomide which could result in a higher serum level. Acetazolamide Acetazolamide may increase the excretion rate of Lenalidomide which could result in a lower serum level and potentially a reduction in efficacy. Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Lenalidomide which could result in a higher serum level.Additional Data Available
- Extended DescriptionExtended DescriptionAvailable for Purchase
Extended description of the mechanism of action and particular properties of each drug interaction.Learn more
- SeveritySeverityAvailable for Purchase
A severity rating for each drug interaction, from minor to major.Learn more
- Evidence LevelEvidence LevelAvailable for Purchase
A rating for the strength of the evidence supporting each drug interaction.Learn more
- ActionActionAvailable for Purchase
An effect category for each drug interaction. Know how this interaction affects the subject drug.Learn more
- Food Interactions
- Take with or without food. High-fat meals decrease absorption, but not to a clinically significant extent.
Purchasing individual compounds or compound libraries for your research?Learn More
- International/Other Brands
- Ladevina / Lenangio
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region ImageUnlock Additional Data Revlimid Capsule 15 mg Oral Celgene 2008-10-10 Not applicable Revlimid Capsule 25 mg Oral Celgene Europe Limited 2007-06-14 Not applicable Revlimid Capsule 25 mg/1 Oral Celgene Corporation 2006-06-29 Not applicable Revlimid Capsule 10 mg/1 Oral Celgene Corporation 2005-12-27 Not applicable Revlimid Capsule 5 mg Oral Celgene Europe Limited 2007-06-14 Not applicable Revlimid Capsule 20 mg Oral Celgene 2015-09-28 Not applicable Revlimid Capsule 20 mg Oral Celgene Europe Limited 2007-06-14 Not applicable Revlimid Capsule 7.5 mg Oral Celgene Europe Limited 2007-06-14 Not applicable Revlimid Capsule 10 mg Oral Celgene 2008-02-19 Not applicable Revlimid Capsule 15 mg Oral Celgene Europe Limited 2007-06-14 Not applicableAdditional Data Available
- Application NumberApplication NumberAvailable for Purchase
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.Learn more
- Product CodeProduct CodeAvailable for Purchase
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.Learn more
- ATC Codes
- L04AX04 — Lenalidomide
- Drug Categories
- Acids, Carbocyclic
- Angiogenesis Inhibitors
- Angiogenesis Modulating Agents
- Antineoplastic Agents
- Antineoplastic and Immunomodulating Agents
- Drugs that are Mainly Renally Excreted
- Growth Inhibitors
- Growth Substances
- Heterocyclic Compounds, Fused-Ring
- Imides
- Immunologic Factors
- Immunosuppressive Agents
- Isoindoles
- Myelosuppressive Agents
- P-glycoprotein substrates
- Phthalic Acids
- Phthalimides
- Piperidines
- Piperidones
- Thalidomide Analog
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as isoindolones. These are aromatic polycyclic compounds that an isoindole bearing a ketone.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Isoindoles and derivatives
- Sub Class
- Isoindolines
- Direct Parent
- Isoindolones
- Alternative Parents
- Alpha amino acids and derivatives / Isoindoles / Piperidinediones / Delta lactams / Benzenoids / Tertiary carboxylic acid amides / N-unsubstituted carboxylic acid imides / Dicarboximides / Azacyclic compounds / Primary amines / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds show 4 more
- Substituents
- Alpha-amino acid or derivatives / Amine / Amino acid or derivatives / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Carboxylic acid imide / Carboxylic acid imide, n-unsubstituted / Delta-lactam / Dicarboximide / Hydrocarbon derivative / Isoindole / Isoindolone / Lactam / Organic nitrogen compound / Organic oxide / Organic oxygen compound / Organonitrogen compound / Organooxygen compound / Organopnictogen compound / Piperidine / Piperidinedione / Piperidinone / Primary amine / Tertiary carboxylic acid amide show 18 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- dicarboximide, aromatic amine, piperidones, isoindoles (CHEBI:63791)
Chemical Identifiers
- CAS number
- 191732-72-6
- InChI Key
- InChI
- InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
- IUPAC Name
- 3-(4-amino-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
- Synthesis Reference
Surya Narayana Devarakonda, Sesha Reddy Yarraguntla, Vamsi Krishna Mudapaka, Rajasekhar Kadaboina, Veerender Murki, Amarendhar Manda, Venkata Rao Badisa, Naresh Vemula, Rama Seshagiri Rao Pulla, Venu Nalivela, "PREPARATION OF LENALIDOMIDE." U.S. Patent US20110021567, issued January 27, 2011.US20110021567
- General References
- List A, Kurtin S, Roe DJ, Buresh A, Mahadevan D, Fuchs D, Rimsza L, Heaton R, Knight R, Zeldis JB: Efficacy of lenalidomide in myelodysplastic syndromes. N Engl J Med. 2005 Feb 10;352(6):549-57. [PubMed:15703420]
- Chang DH, Liu N, Klimek V, Hassoun H, Mazumder A, Nimer SD, Jagannath S, Dhodapkar MV: Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications. Blood. 2006 Jul 15;108(2):618-21. Epub 2006 Mar 28. [PubMed:16569772]
- Anderson KC: Lenalidomide and thalidomide: mechanisms of action--similarities and differences. Semin Hematol. 2005 Oct;42(4 Suppl 4):S3-8. [PubMed:16344099]
- External Links
- Human Metabolome Database
- KEGG Drug
- PubChem Compound
- 216326
- PubChem Substance
- 46505725
- ChemSpider
- 187515
- BindingDB
- 65454
- 342369
- ChEBI
- 63791
- ChEMBL
- Therapeutic Targets Database
- PharmGKB
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Lenalidomide
- AHFS Codes
- 10:00.00 — Antineoplastic Agents
- FDA label
- Download (400 KB)
- Download (225 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Active Not Recruiting Treatment Multiple Myeloma (MM) 1 4 Active Not Recruiting Treatment Relapsed and/or Refractory Multiple Myeloma 1 4 Completed Treatment Cutaneous Lupus 1 4 Completed Treatment Multiple Myeloma (MM) 1 4 Not Yet Recruiting Treatment Novel Coronavirus Infectious Disease (COVID-19) 1 4 Recruiting Treatment Multiple Myeloma (MM) 3 4 Recruiting Treatment Newly Diagnosed Multiple Myeloma 1 4 Recruiting Treatment NK/T Cell Lymphoma 1 4 Recruiting Treatment Peripheral T-Cell Lymphoma (PTCL) 1 4 Recruiting Treatment Relapsed Or Refractory Multiple Myeloma 1
- Manufacturers
- Celgene corp
- Celgene Corporation
- Packagers
- Celgene
- Norwich Pharmaceuticals Inc.
- Penn Pharmaceutical Services Ltd.
- Dosage Forms
Form Route Strength Capsule, coated Oral 10 mg Capsule, coated Oral 15 mg Capsule, coated Oral 25 mg Capsule, coated Oral 5 mg Capsule Oral 10 mg/1 Capsule Oral 10 mg Capsule Oral 15 mg Capsule Oral 15 mg/1 Capsule Oral 2.5 mg Capsule Oral 2.5 mg/1 Capsule Oral 20 mg/1 Capsule Oral 20 mg Capsule Oral 25 mg Capsule Oral 25 mg/1 Capsule Oral 5 mg Capsule Oral 5 mg/1 Capsule Oral 7.5 mg
- Prices
Unit description Cost Unit Revlimid 25 mg capsule 411.71USD capsule Revlimid 15 mg capsule 407.7USD capsule Revlimid 10 mg capsule 406.05USD capsule Revlimid 5 mg capsule 388.0USD capsuleDrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) RegionUnlock Additional Data CA2477301 No 2009-09-01 2023-04-13 CA2342974 No 2005-08-16 2014-02-24 US6045501 No 2000-04-04 2018-08-28 US6315720 No 2001-11-13 2020-10-23 US6561976 No 2003-05-13 2018-08-28 US6561977 No 2003-05-13 2020-10-23 US6755784 No 2004-06-29 2020-10-23 US6908432 No 2005-06-21 2018-08-28 US8204763 No 2012-06-19 2018-08-28 US8315886 No 2012-11-20 2020-10-23 US8626531 No 2014-01-07 2020-10-23 US8589188 No 2013-11-19 2018-08-28 US7468363 No 2008-12-23 2023-10-07 US6281230 No 2001-08-28 2016-07-24 US8530498 No 2013-09-10 2023-05-15 US6555554 No 2003-04-29 2016-07-24 US7189740 No 2007-03-13 2023-04-11 US7968569 No 2011-06-28 2023-10-07 US8404717 No 2013-03-26 2023-04-11 US8648095 No 2014-02-11 2023-05-15 US8741929 No 2014-06-03 2028-03-08 US9101622 No 2015-08-11 2023-05-15 US9101621 No 2015-08-11 2023-05-15 US9056120 No 2015-06-16 2023-04-11 US5635517 No 1997-06-03 2019-10-04 US7119106 No 2006-10-10 2016-07-24 US7465800 No 2008-12-16 2027-04-27 US7855217 No 2010-12-21 2024-11-24 US8288415 No 2012-10-16 2016-07-24 US9393238 No 2016-07-19 2023-05-15 US8492406 No 2013-07-23 2023-10-07 US9155730 No 2015-10-13 2023-05-15Additional Data Available
- Filed OnFiled OnAvailable for Purchase
The date on which a patent was filed with the relevant government.Learn more
- State
- Solid
- Experimental Properties
Property Value Source water solubility Soluble in organic solvent/water mixtures, and buffered aqueous solvents. Lenalidomide is more soluble in organic solvents and low pH solutions. Solubility was significantly lower in less acidic buffers, ranging from about 0.4 to 0.5 mg/mL. Not Available logP -0.4 Not Available
- Predicted Properties
Property Value Source Water Solubility 2.33 mg/mL ALOGPS logP -0.43 ALOGPS logP -0.71 ChemAxon logS -2 ALOGPS pKa (Strongest Acidic) 11.61 ChemAxon pKa (Strongest Basic) 2.31 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 4 ChemAxon Hydrogen Donor Count 2 ChemAxon Polar Surface Area 92.5 Å2 ChemAxon Rotatable Bond Count 1 ChemAxon Refractivity 68.3 m3·mol-1 ChemAxon Polarizability 25.55 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon
- Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9958 Blood Brain Barrier + 0.9372 Caco-2 permeable - 0.5981 P-glycoprotein substrate Substrate 0.6845 P-glycoprotein inhibitor I Inhibitor 0.6012 P-glycoprotein inhibitor II Non-inhibitor 0.8927 Renal organic cation transporter Non-inhibitor 0.726 CYP450 2C9 substrate Non-substrate 0.8861 CYP450 2D6 substrate Non-substrate 0.7878 CYP450 3A4 substrate Substrate 0.5855 CYP450 1A2 substrate Non-inhibitor 0.8746 CYP450 2C9 inhibitor Non-inhibitor 0.8405 CYP450 2D6 inhibitor Non-inhibitor 0.8806 CYP450 2C19 inhibitor Non-inhibitor 0.78 CYP450 3A4 inhibitor Non-inhibitor 0.7469 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.843 Ames test Non AMES toxic 0.8268 Carcinogenicity Non-carcinogens 0.9068 Biodegradation Not ready biodegradable 0.9967 Rat acute toxicity 2.5145 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9803 hERG inhibition (predictor II) Non-inhibitor 0.5098
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available LC-MS/MS Spectrum - LC-ESI-qTof , Positive LC-MS/MS Not Available MS/MS Spectrum - , positive LC-MS/MS splash10-0002-1920000000-c10c48acd9b8123e3505
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Metal ion binding
- Specific Function
- Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Norma...
- Gene Name
- Uniprot ID
- Uniprot Name
- Protein cereblon
- Molecular Weight
- 50545.375 Da
- Zhu YX, Kortuem KM, Stewart AK: Molecular mechanism of action of immune-modulatory drugs thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54(4):683-7. doi: 10.3109/10428194.2012.728597. Epub 2012 Sep 28. [PubMed:22966948]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Tumor necrosis factor receptor superfamily binding
- Specific Function
- Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be...
- Gene Name
- Uniprot ID
- Uniprot Name
- Tumor necrosis factor ligand superfamily member 11
- Molecular Weight
- 35477.81 Da
- Akobeng AK, Stokkers PC: Thalidomide and thalidomide analogues for maintenance of remission in Crohn's disease. Cochrane Database Syst Rev. 2009 Apr 15;(2):CD007351. doi: 10.1002/14651858.CD007351.pub2. [PubMed:19370685]
- Melchert M, List A: The thalidomide saga. Int J Biochem Cell Biol. 2007;39(7-8):1489-99. Epub 2007 Jan 30. [PubMed:17369076]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Antagonist
- General Function
- Receptor binding
- Specific Function
- Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of hete...
- Gene Name
- Uniprot ID
- Uniprot Name
- Cadherin-5
- Molecular Weight
- 87527.715 Da
- Lu L, Payvandi F, Wu L, Zhang LH, Hariri RJ, Man HW, Chen RS, Muller GW, Hughes CC, Stirling DI, Schafer PH, Bartlett JB: The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res. 2009 Mar;77(2):78-86. doi: 10.1016/j.mvr.2008.08.003. Epub 2008 Sep 4. [PubMed:18805433]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Negative modulator
- General Function
- Prostaglandin-endoperoxide synthase activity
- Specific Function
- Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
- Gene Name
- Uniprot ID
- Uniprot Name
- Prostaglandin G/H synthase 2
- Molecular Weight
- 68995.625 Da
- Payvandi F, Wu L, Haley M, Schafer PH, Zhang LH, Chen RS, Muller GW, Stirling DI: Immunomodulatory drugs inhibit expression of cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS-stimulated human PBMC in a partially IL-10-dependent manner. Cell Immunol. 2004 Aug;230(2):81-8. [PubMed:15598423]
- Zeldis JB, Schafer PH, Bennett BL, Mercurio F, Stirling DI: Potential new therapeutics for Waldenstrom's macroglobulinemia. Semin Oncol. 2003 Apr;30(2):275-81. [PubMed:12720152]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Xenobiotic-transporting atpase activity
- Specific Function
- Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
- Gene Name
- Uniprot ID
- Uniprot Name
- Multidrug resistance protein 1
- Molecular Weight
- 141477.255 Da
Drug created on June 13, 2005 07:24 / Updated on November 30, 2020 13:38


text:
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Jeru the Damaja
Jeru the Damaja
Kendrick Jeru Davis, known as Jeru the Damaja (born February 14, 1972) spent his early years in the Brooklyn neighborhood of East New York, where he has been rapping at block parties since the early days of his youth. He first showcased his hardcore Brooklyn style to audiences on "I'm the Man," a track from Gang Starr's 1992 album Daily Operation. The following year he released his first single, "Come Clean", which was produced by DJ Premier and became an instant underground hit. His first album, The Sun Rises in the East, released in 1994, and produced entirely by DJ Premier, is considered a classic, and was one of the most acclaimed Hip Hop albums of its time.
As an interesting side note, the album cover shows the World Trade Center on fire only one year after the 1993 bombing of the North Tower. The album featured Jeru's signature conscious lyrics, however he was criticized by The Fugees for his explicit lyrics particularly, in the song "Da Bichez". Fugees member Pras lightly mentioned Jeru on the track "Zealots", from the group's landmark 1996 album The Score, with the line "No matter who you damage, you're still a false prophet", referencing Jeru's single "You Can't Stop the Prophet". Jeru lightly responded in the intro to the track "Me or The Papes".
Jeru followed up in 1996 with his sophomore album Wrath of the Math again produced solely by DJ Premier. The album was also widely acclaimed, though not on the same level as his debut. Like on his first album, Jeru was accusatory of commercial hip hop artists and record labels (Death Row, Bad Boy), who he criticized on the concept track "One Day". After the release of Wrath of the Math, Jeru had a falling out with DJ Premier and Guru, and was missing from the scene until 1999, when he released his third album, Heroz4hire, released together with Mizmarvel. Heroz was his first album without production from DJ Premier and also his first under his then newly created KnowSavage Records. It featured the single "99.9 Pa Cent", which was a verbal attack on his former affiliates Gang Starr. Heroz4hire was less critically acclaimed, due mostly to Premier's absence. His latest album, Divine Design, released in 2003, was the first album under his new record label, Ashenafi Records. The album received little attention and mixed reviews. A new Jeru album, tentatively titled Still Rising was released in 2007.
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text:
I need the sensor wires How do I get them and how much do they cost?
nee the sensor wires where do I get a set or can I order them on line?
Is dit een goede vraag?
Cen-Tech Seven Function Digital Multimeter . Model number 90899.
Rep: 1
nee the sensor wires where do I get a set or can I order them on line?
Rep: 96,1k
jmessina , I assume you are talking about replacement leads/test probes. Take a look at the 1st link, in the picture it looks like these may fit your multi meter. 2nd link shows the whole meter can be purchased for $6.95. From the manual it list this info. to make inquiries about the meter,(3491 Mission Oaks Blvd. • PO Box 6009 • Camarillo, CA 93011 • (800) 444-3353). Good luck.
I hope this helped you out, if so let me know by pressing the helpful button.
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text:
Therefore, do not blame them. Until 1st September he served as Chief Rabbi of the United Hebrew Congregations of the Commonwealth, having held the position for 22 years. Limits are necessary with Spirituality and Life. It was the metal of which the calf was made, while Moses was on the mountain receiving the Torah from God. That is why they were listened to when they urged people to change and grow. Why then attach it here, to an obscure place-name in the first verse of Deuteronomy, where it is radically out of keeping with the plain sense of the verse. What does it take for criticism to be heeded? But the midrash about Moses tells us a life-changing idea : If you seek to change someone, make sure that you are willing to help them when they need your help, defend them when they need your defense, and see the good in them, not just the bad. What is odd in the verse is the last place-name: Di-zahav.
© 2020 gianphoihoaphatair.com - All rights reserved. All Models are over 21 y.o.


text:
Contact Number:+977-1-4442066 / 4442067
"The time spent in Malpi has been quite influential, to say the least, to me, both as a student and a person. The competitive atmosphere I'd found myself in has done a wondrous job in shaping the driven and focused character that I've come to aspire after. The other, characteristic side to Malpi that manifests in the enthusiasm of the student council, the faculty members and the students themselves, often in illustrious projects such as the 2017 Malpi Cup, has definitely been something to behold, and has, not only made Malpi that much more memorable, but has also been much impactful in teaching a sincere respect for creative synergy and meaningful interactions. All in all, it has been a much meaningful two years.
Pulling off a top in Nepal is not something I might have ever deemed feasible for myself. To be able to do so, especially in a subject I do very much enjoy investing myself in, is very much a fulfilling experience. My sincerest thanks to everything and everyone that deserves credit for helping me get here."
"When someone asks me what my biggest achievements are, I simply answer them,' bagging experiences and learning from my mistakes.' My 2 years in Malpi has been absolutely phenomenal. In Malpi, I was taught by an excellent set of experienced teachers who are very motivating and are dedicated to help us reach our potentials. The management was always keen to listen to our ideas and they always made sure they fulfilled all our meet able demands. Being the country topper in GP, hosting several intra and inter college tournaments, competitions, working as the Student Council President have been some of my biggest achievements but most of all, getting chances to learn from my mistakes, experiencing some surreal moments outside the books and being handed with so many opportunities and duties in my college has been my biggest achievements. Malpi is not just a regular college. It enhances your capabilities and helps you grow as a person.
As I graduate from Malpi now, I am not leaving with just academic excellency awards, but experiences that has made me more confident. I am graduating with the willingness to strive for more and as a better person. "


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Michael Grahame Moore
2881 days ago
Reflections about Collective and Independent Study by M. G. Moore
...on this theme as different as the ones of Michael G. Moore and of Cristóbal Cobo. I...ed my dear friend and EDEN Senior Fellow, Michael G. Moore, to contribute to today's...uot; Harvard Educational Review 38 no. 4. Moore, Michael G. (1973) Towards a theory...
1658 days ago
Winners of the EDENRW8 Best Research Paper Award
...aughn, Memorial University, Newfoundland/Canada (Chair of the Jury: Michael Grahame Moore, Pennsylvania State University/...u &Tim Seifert, Memorial University, Canada (Chair of the Jury: Michael Kerres, University of Duisb...
2223 days ago
February, 2019 EDEN Conference News...arning: Global Approaches and Experiences This book by Micha...
642 days ago
...ut Collective and Independent Study by M. G. Moore Imagine...tion of learning as different as the ones of Michael G. Moore and of Cristóbal Cobo....rest, in this guest post EDEN Senior Fellow, Michael G. Moore offers a thought-p...
1645 days ago
EDEN Fellows and Senior Fellows
...N Senior Fellow awards Alan Tait http://www.eden-online.org/nap_elgg/pg/profile/awtait Michael G. Moore http://www.eden-online.org/nap_elgg/pg/profile/mgmoore Martine Vida...
3815 days ago
Michael G Moore in interview with Steve Wheeler in Oslo | VIDEO
tag_names:tags: edenoslo, conference, interview, distance, steve wheeler, michael g moore, video
2723 days ago


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Sleeping Braid Waves Hairstyle Tutorial
Sleep with pigtails, why is it comfortable and nice to your hair in a braid at bedtime? Did you know, for example, long hair, but suffered from the big tangles, then it is good to make a braid in your hair after showering. The braid ensures that no tangles come to her and that your hair is easily combed out the next day. Ideal for long and short hair. When you sleep with braids, it is better to weave the braid, so keep the hair nice and put you together well.
How can you sleep with braids?
This wonderful weave pattern is one step for you.
Step 1
When you come, you'll comb your hair back and use a hair serum to keep the hair out of the shower in the right place.
If the hair is dry, it is damp and moist then take a hair serum.
step 2
Take a tuft at the front of the head to spread the puck through three strands, and decide whether to invite or braid.
step 3
Get as skinny as possible when you get started, because she's feeling better.
Step 4
braid the hair all the way down until you can not continue the braid, then secure it with a good elastic band.
Then you can sleep.
Video tutorial
Long braided hairstyle tutorials
There are very simple methods to make a long braided hair model. To avoid hair wear, follow the procedures above to get a fuller and more vibrant hair.
Inspiration braiding
Do you want to make more creative braids? Splash with the hottest hair braiding moment.


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Former West Coast captain Guy McKenna reveals thought process behind infamous headcount call
Former West Coast captain Guy McKenna has re-lived the bizarre moment he called for a headcount when his team was getting flogged by St Kilda.
The fan favourite became only the third captain to ever call for the umpires to count the on-field troops, when he made the request in round 22 of the 1999 season.
Playing at the WACA Ground and trailing by 49-points at the time, 'Bluey' said he was adamant the Saints had an extra player on the ground.
"At the time we were getting absolutely belted by St Kilda, I've turned around and I saw six defenders, six forwards but then I saw another St Kilda fella down there," McKenna recalled on the Front Bar.
"The ball was up in our forward line, I'm thinking 'what the hell is going on here?'. If you're going to have a loose player, and you're a St Kilda person, I think you'd be back where the ball is wouldn't you?
"But he was down in our forward line!
"I'm going 'What the hell's going on!' I had a quick count through the midfield, I couldn't tell that far in the forward 50 but I had a quick look at the bench.
"Back in those days there was either two or three on the bench but someone was missing from the bench. So I thought 'Well here he is here!', so I put my hand up and said to the umpire, 'I reckon there's an extra bloke on the ground here'.
"He turned around and had a look and said: 'Well what do you want to do?!'. So I said 'Can I call a headcount?!'
"He asked me about two or three times if I was sure before he eventually blew the whistle.
"We all came in and the St Kilda boys are looking at me, laughing and saying 'You're kidding yourself Bluey', I wasn't doing it for any reason - I legitimately thought they had an extra."
The umpires lined the players up to confirm St Kilda didn't have an extra player on the field - with the Front Bar panel suggesting it could be a brilliant momentum-changing tactic in a grand final.
"I think by the time everyone came in it took about five minutes," Bluey said, when asked how long the match was halted for.
"If someone's kicked six in a row in a grand final, what's to stop you from calling a headcount and taking five minutes out?" Mick Molloy asked.
"The new rule," McKenna swiftly responded.
"You get the score squashed and go back to zero."
The panel jokingly suggested the adjusted legislation may be known as 'the Guy McKenna rule' following the odd moment in the 41-point loss.
Under the new rule, if you unsuccessfully request a headcount, your team's total score is now scrapped to zero.
The first-ever successful headcount took place in 2013 when Frankston was penalised for having 19 players on the field during a VFL clash.
North Ballarat correctly identified the extra man, which saw Frankston's 38-point total adjusted to zip, handing the former a 41-point win.
The infamous headcount was one of two unusual on-field distinctions, with McKenna also becoming the first player to ever be pulled from the ground under the blood rule.
The new proceedings had only been introduced that week when the 267-gamer was ordered from the field in round 20, 1994.
Safe to say we'll probably leave the headcount rule out of play in future.
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Invite to the Top10Archive! Continuing our grand trip of the world, we're journeying back to the southerly hemisphere to discover the very suggested, South Africa! From spectacular falls as well as magnificent wildlife, to being house to several of one of the most intriguing shipwrecks to have actually ever before been found, we'll take a look at 10 Impressive facts regarding South Africa!
Assistance us by going shopping on Amazon.com!
10. Popularity of South Africa
9. South African Advancements
8. South African Food
7. Vacationer Attractions
6. South African Wild Animals
5. Increase in Education and learning
4. South African Nature Destinations
3. Nuts over Mining and also Minerals
2. A Land of Shipwrecks
1. The Cradle of Humanity
Voice Over Skill:


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This service definitely took our event to the NEXT LEVEL!!!!! The host went above and beyond preparing our theme. I will recommend them to everyone I know and they will always be my go to. Thank you for such a fun and new experience. This service was the talk of the party!!!!!
I highly recommend Next-level Fotoboothing for any kind of event, lots of creativeness, very enthusiastic, and amazing, endless, decorations, for the 1 yr young baby girl, birthday celebration. Amazing time..try it! High 5+ to Carlos & Jennifer..thanks
Next Level Fotoboothing gave us a perfect experience. From the state of the art equipment, to the adorable props (shout out to the dinosaur head) to the kindness and professionalism of the staff, they absolutely made our event! I have worked with MANY MANY photobooths in my 13 year career and Next Level Fotoboothing is my hands down favorite, no question. You cannot go wrong! Simply put Next Level Fotobooth will elevate your event and your guests will be sharing these pictures for years to come. BOOK NEXT LEVEL FOTOBOOTH! YOU WILL NOT BE SORRY
Guests loved the photobooth and props. Owners were wonderful to work with pre and during the event. Will 100% be using this company for other events.
Jennifer was very hands on throughout the entire process, which made my whole life!
I will certainly conduct business with Next Level Fotoboothing again!


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Open Mouth Baggers OM2 Series
The OM2 Series of open mouth baggers use a patented self-damping beam scale for reliability and accuracy when filling bags.
Need more information? Message Aurora Process Solutions via the form, or call and say you found them on IndustrySearch so they can best assist you.


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Brown Cotton Kurta with Palazzo
Steal all the attention at your get-together with this gorgeous brown kurta palazzo set by Zola. It features 3/4th flared sleeves and round neckline on a synthetic fabric buckling comfort throughout the day. With the golden piping pattern, kurta boasts of enticing urbanity. Wear this kurta set to evening events, pairing it with stunning, gold jewellery and accessories.
- Fabric : Art Silk
- Color : Brown
- Collar : Band / Mandarin / Chinese Collar
- Sleeve : Roll Up Sleeves
- Products : Plazo Set
- Style Code : 078055


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The Principal® Foundation Relief Fund was created to assist individuals who have experienced unexpected financial hardship due to a qualified disaster. Emergency relief grants may be made for immediate food, clothing, housing and transportation needs. The Principal® Foundation started this fund with an initial contribution and encourages others that want to help to consider a donation. Every contribution helps, regardless of the amount. Together, we can support individuals when they are facing the unexpected.
If you are experiencing a personal financial hardship because of a qualified disaster you can apply for a grant for assistance. Please read the Application FAQ to see if you qualify.
The Emergency Assistance Foundation, Inc. will manage all fund activities, and when needed assist applicants with their grant applications. Principal Foundation will not have any insight into the grant process unless a grant recipient chooses to share his or her story.
The Emergency Assistance Foundation is here to help applicants through their challenging times. Please click the link above for social service suggestions, educational courses that cover everything from disaster preparedness to financial education and more.


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New England manager Roy Hodgson brought Gary Neville on board ahead of this summer's European Championships. The former Manchester United defender, who retired earlier this season, will juggle the England job with his role as analyst on Sky Sports. But Phil Neville does not believe there will be a clash of interests.
"I know what Gary will do for the squad," Neville told Sportsweek on BBC Radio Five Live. "It came as a bolt out of the blue. He has had such a successful time with Sky and I think he was looking to put his feet up this summer. The first thing I thought was 'what a clever move by Roy Hodgson'."
He added: "From a PR exercise, he has not gone for a yes man, he has gone for someone who will challenge him and the team.
"I think it was a masterstroke. There is a new era coming in now. I am really positive and quite excited.
"I think the appointment of Roy Hodgson was a clever one and the appointment of my brother as his number two excited me even more.
"He (Gary) is someone who has played in five major tournaments, played nearly 90 times for England and someone who has played with nearly all the players - but he has had a year away from them, which gives that distance.
"He is well respected and the year he has had on the telly has won a lot of people over. He has had success in the Premiership, he has won titles and the Champions League.
"His biggest strength will be his honesty. People will say 'you can't go on telly one week and be a coach the next'.
"Let me tell you one thing about Gary, whatever he says on TV he would be prepared to say to a players' face in the changing room. Gary will be honest. He has so much enthusiasm for wanting England to do better."


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Arthritis from a Holistic Perspective
We have a 100% money-back guarantee, to support our firm belief in our products, and to build trust in customers who have been facing battles they thought would be lifelong! You may return the products within 90 days of your order date for a full refund of the purchase price. You may alternatively request a free consultation and additional remedies if you are not 100% better. Our mission is fulfilled only when you are better. Hence, we stand by our customers and do what it takes to make you feel great! We can afford to do this, because the customers who re-order or refer us to friends and family, are 20 times more than those who ask for a return. So, go ahead and give us a try. You'll be glad you did.
The Biogetica Approach
Biogetica is a collective of Drs and Holistic Healthcare practitioners dedicated to holistic healing, with evidence based natural remedies & advanced bio energetic therapies.
- Heal the entire being
Heal the entire being
Biogetica has a unique and comprehensive Holographic model of healing which synthesizes all prevalent medicine systems to simultaneously ease physical, energetic, mental and emotional layers of your being. Our full spectrum approach works across the entire physical, energetic and informational spectrum of life. Totality is our Modality and we are always open to any tradition or treatment that will benefit you.
Every thought, emotion, vibration or action leads to a series of chemical changes in the body. All ailments are a result of disharmony in the life force. Biogetica recognizes this and balances the ENTIRE BEING, bringing mind, body and soul into harmony, for lasting results. Treating an ailment on molecular level alone, seldom has a lasting effect as the untreated social, emotional, mental, spiritual and energetic patterns will cause the ailment to manifest once again on a physical plane.
Holistic healing is necessary for lasting relief. Biogetica, therefore, uses Resonance Homeopathy to harmonize the entire being; flower essences to attune the mind; Ayurvedic, Amazonian, Tibetan and Chinese herbs to balance the energetic and the physiological manifestation of the five elements; and nutraceuticals to coordinate cellular nutrition. Our approach works across the spectrum of life to balance matter and energy whilst using archetypes of the undying spirit to remind the entropic physical body of its optimal functions. Each human is a child of immortality pre-programmed to perform a billion functions with a mind boggling precision that most science cannot comprehend. Each of our kits potentially provides specific nutrition needed for a particular function, the herbs in these kits balance the terrain of the body to make it conducive to that function and the vibrational therapies potentially help bring balance.
- Look for natural solutions
Look for natural solutions
Our bodies are made of and supported by nature and therefore can only be healed by nature in the long term. Chemicals are often necessary for immediate change in an acute situation but tend to do the body more harm than good in the long run. Hence, Biogetica's Doctors are dedicated to providing natural solutions that are supported by evidence and prior use. To us, the argument is fairly obvious: One would use wood to fix a desk made of wood or metal to fix a car made of metal, so why use chemicals to fix a body made of nature?
Nature has blessed the Earth with natural medicines and healing mechanisms. It would be wise not to ignore them. The intelligence of nature is much greater than that of man. Unfortunately, man still focuses on chemical medicines, as they can be patented and sold for huge profits. Allopathic attempts to treat chronic ailments by interfering directly with the chemical processes using man-made substances, has essentially been a failure. We claim to be cracking the gene code, but we still can't cure a cold with man-made substances!!! Homeopathic and Naturopathic methods are never studied and verified by governing bodies, as there is no one who will spend millions obtaining an approval on herbs, knowing that they cannot be patented and sold exclusively by them.
- Appeal to the balancing forces inherent in all nature
Appeal to the balancing forces inherent in all nature
Life cannot be recreated with chemical interactions and there is much more to life than molecular interactions. Our bodies are the most advanced pharmacies on the planet and millions of functions happen each minute with astounding precision. Biogetica therapies are designed to appeal to the balancing forces apparent in all nature by reminding and stimulating the body towards a certain function. The nutraceuticals in our kits provide specific nutrition for a function, the herbs in our kits balance the terrain of the body so that it is able to perform that function and the resonance homeopathics are designed to remind the body to be in resonance with that very function.
- From medication to meditation
From medication to meditation
Good health and freedom involves every aspect of our being including diet, lifestyle, exercise, emotional states, thoughts and energetic patterns. Biogetica Drs have therefore designed diet, nutrition, exercise and meditation protocols specific to various life situations. We encourage you to actively partake in these for best results.
Evidence Based Natural Solutions
Biogetica's mission is to heal the people of this globe with evidence based natural remedies and thereby once again give nature's medicines the respect they deserve.
Our Doctors believe that a holistic approach, aimed at the physical and energetic root causes, is necessary for sustainable relief and freedom.
Studies have indicated that ingredients may possess joint support abilities.
Studies suggest that these herbs may reduce inflammation and stimulate bone and cartilage regeneration in the body.
Resonance Homeopathy
Studies suggest that these resonance homeopathic remedies may relieve symptoms of pain, swelling and stiffness.
Testimonials†See what our existing Customers have to say about these productsResults may vary from individual to individualTestimonials for this ailment have been intentionally hidden as testimonials claiming a cure or treatment are not permitted as per law regardless of their authenticity.
Deliverance Kit with OM 16 Formulawith Homeopathic H-factor Nosodes
OM 16 Knees
OM 16 Knees is an advanced combination of natural resonance Homeopathic and homotoxologic remedies. This natural remedy is traditionally believed to work by: **
- Optimizing functions of the joints such as knees, elbows, etc
- Strengthening the cartilage surrounding your joints
- Improving mobility and flexibility
Osheal tablet
Osheal tablets contain potent herbs, which are traditionally believed to support the functions of the ligaments, joints and muscle tissues. **
Osheal contains time-tested herbs prescribed by Ayurvedic practitioners for supporting structure of the bones They are believed to impart tensile strength to the skeletal framework.
Arthrose is a bioregulator that improves the nutritional and energy state of the body. It potentially regulates and sustains optimal joint health. **
The mechanism of action is believed to: **
- Regenerate bioinformation and articulate energy patterns.
- Provide energy to the bone and joint systems including the cartilage, bone and synovial tissue.
- Help maintain the natural activation of compensatory mechanisms to the biological effects of free radicals at a bone-joint level with consequent natural restoration of the membrane's quality for the correct transfer of intercellular bio-information.
- Regulate energy of the natural immune events that bring about healing of the joints.
- Balance the energy of the endocrine axis related to the bones, joints and ligaments.
- Assist in maintaining the natural drainage of toxic substances deposited in the connective tissue, and alter collagen and supporting tissues.
- Help support healthy natural metabolic regulation of tissues that compose the joint system.
Arthrosolve is a combination of Ayurvedic herbs traditionally used for joint support. **
OM 16 Knees
Ingredients: Potent Bioenergetic impressions with no actual molecules of: Synovial fluid, Synovial membrane, Cartilage
Dosage: 4 pills, 3 times a day.
Osheal tablet
Ingredients: Each tablet contains (in mg)
Hadsandhari (Cissus quadrangularis) 75mg, Arjuna Chaal (Terminalia arjuna) 75mg, Lakh (Laccifer lacca) 75mg, Methi beej (Trigonella foenum graeucum) 75mg, Shuddha Guggul (Commiphora mukul) 53mg, Salai Guggul (Boswellia serrata) 25mg, Ashwagandha (Withania somnifera) 10mg, Haridra ext. (Curcuma longa) 8.50mg, Bala ext. (Sida cordifolia) 8mg, Soonth (Zingiber officinalnale) 5mg, Nirgundi ext. (Vitex negundo)3mg.
Dosage: 1-2 tablets twice a day for 2 months
Shark Cartilage, Hydrolyzate fish collagen, OptiMSM, Chondroitin sulfate, L-Proline, L-Tyrosine, Quercetin (Sophora japonica L.), L-Arginine, Rosehip (Rosa canina), Maca (Lepidium meyenii), Devil's claw (Harpagophytum procumbens), Ca gluconate, Resveratrol (Polygonum cuspidatum), Mg gluconate, Hawkweed (Hieracium pilosella), k gluconate, Tricalcium phosphate, Sodium hyaluronate, L-Glutathione, Silicon dioxide, Vitamins B2, B6, B1.
- Group I. Activated substrate micronutrient joint: Shark cartilage (8-12% glucosamine sulfate, 14-20% chondroitin sulfate) 75 mg, Collagen hydrolysatefish (PeptanTM F 5000 HD) 55 mg, OptiMSM (99.8% methyl sulfonyl methane) 50mg,Chondroitin sulphate (shark, 90%) 45 mg, Sodium hyaluronate 3 mg.
- Group II. Anti-oxidants: Quercetin (Sophora japonica L Rosebud flower 95%) 32 mg, Resveratrol (Polygonumcuspidatum root) 10 mg, Reduced L-Glutathione (GSH) 2 mg.
- Group III. Herbal extracts: Rosehip (Rosa canina, fruit, 0.2% dry extract Ascorbic acid) 27 mg Maca dry extract (Lepidiummeyenii, root, ratio 4:1) 22mg Devil's claw dry extract (Harpagophytumprocumbens DC, root 2% harpagoside) 12 mg, Dry extract hawkweed(Hieraciumpilosella l., flower, 0.3% umbeliferona) 5 mg.
- Group IV. Amino acids: L-Proline 38 mg, L-tyrosine 32mg,L-arginine 30 mg.
- Group V. Vitamins and minerals: Calcium Gluconate (8.94% calcium) 12 mg, Magnesiumgluconate (5.86% magnesium) 6 mg, Potassium gluconate(16.69% potassium) 3 mg, Tricalcium phosphate (38.76% calcium, 19.97% match) 3 mg, Silicon dioxide 0.4 mg, Vitamin B2(riboflavin) 0.1 mg, Vitamin B6 (pyridoxine hydrochloride) 0.1 mg,Vitamin B1 (thiamine hydrochloride) 0.08 mg.
Contents: 60 Capsules (560 mg).
Instructions: Take 1 or 2 a day, preferably prior to breakfast and dinner Or as advised by your physician.
Guggul Ghan Niryas Commiphora Mukul 60
Shallaki Ghan Niryas Boswellia Serrata 41
Rasna Ghan Leaves Pluchea Lanceolata 25
Nirgundi Ghan Leaves Vitex Negundo 18
Methika Ghan Seed Trigonella Foenumgraecum 18
Punarnava Ghan Root Boerhaavia Diffusa 15
Shilajit Mineral Asphaltum 12
Dashmool Ghan Root Laghu panchamool- 5 Brihat panchamool -5 10
Sunthi Ghan Rhizome Zingiber Officinale 9
Nagarmotha Ghan Root Cyperus Scariosus 9
Erandi oil Leaves Ricinus communis 9
Shaival Powder Leaf Ceratophyllum Demersum 1
Dosage - One to two tablets two times daily after food.
This kit ships internationally, and may take up to 10 days to arrive by Speed Delivery and up to 20 days by Regular (Ground) Delivery. Actual delivery time is usually less than the maximum stated above
Author Box
Dr. Gauri Mane Homeopathic Consultant
Dr. Gauri has a B.H.M.S degree from Maharashtra University of Health Sciences, Mumbai. She topped her class and graduated Magna Cum Laude. She is a licensed Homeopath, with over 4 years of clinical experience in Homeopathy, as well as Allopathy.She has also worked as a Research Coordinator for s...


text: The Executive Branch of Federal Government: People, Process, and Politics By Brian R. Dirck No cover image The Executive Branch of Federal Government: People, Process, and Politics By Brian R. Dirck Read preview Synopsis How has the role of the president changed since George Washington? How does the president interact with Congress? The courts? The states? Other nations? These are just a few of the overarching questions addressed in this volume in ABC-CLIO's About Federal Government set devoted to the president and the executive branch he manages. "The Executive Branch of the Federal Government" provides a brief history of the presidency, then looks at the constitutional powers of the office, the day-to-day functions of the federal bureaucracy, general elections, and presidential relationships with Congress and the courts. But perhaps most compelling are the insights into the officeholders themselves, the individuals who have served as president, each fashioning a term reflective of his own personality. Excerpt Most of us know something about the federal government. At the very least, we can name its three branches—executive, legislative, and judicial—and discuss the differences between them. At an early age, we are taught in school about the president of the United States and his official roles and responsibilities; we learn about Congress and the courts and their place in our government. In civics classes, we often get a skeletal picture of how the nation's government works; we are told that Congress writes the laws, the president executes them, and the Supreme Court acts as the interpreter of the U.S. Constitution. News reports, blogs, and editorials we read as adults add to this knowledge. Many of us can go further and explain some of the basic interactions among the branches. We know that the laws Congress passes are subject to the president's veto power and the Supreme Court's powers of judicial review; we understand that the president names the members of his cabinet and nominates justices to the Supreme Court, but that the Senate has to confirm these nominations; and we can discuss how the Supreme Court, as the "caretaker" of the Constitution, can declare laws unconstitutional, but that it is up to the legislative and executive branches to enforce these rulings. We bandy around such terms as checks and balances and separation of powers. We talk about majority votes and filibusters in the Senate.For most of us, however, this is about as far as our knowledge goes. According to newspaper accounts spanning decades, most Americans have trouble naming members of the Supreme Court, or key figures in the congressional leadership, or the members of the president's cabinet. Still fewer of us can explain in detail how a bill becomes a law, or the president's authority in foreign affairs, or how the Supreme Court decides a case. If we ask about the historical development of these institutions and officials and their powers, the numbers of those who understand how our federal government works drop even further.It is not surprising that most of us do not know a lot about the workings of our government. Government is a large and complex enterprise. It includes thousands of people working on subjects ranging from tax reform to national security, from voting rights to defining and enforcing environmental standards. Much of the work of government, although technically open to the public, is done out of sight and hence out of mind. We may know about those parts of the government that affect us directly—the Social Security Administration for the elderly, the Defense Department for those with family members in the military, or the Supreme Court when the news is filled with such controversial topics as abortion or the right to die or prayer in schools—but our understandings are generally limited to only those parts that directly affect us. Although this state . . . Related books and articles Books Journals Magazines Newspapers Encyclopedia Presidents and the Politics of Agency Design: Political Insulation in the United States Government Bureaucracy, 1946-1997 By David E. Lewis Stanford University Press, 2003 Read preview Overview The Government Taketh Away: The Politics of Pain in the United States and Canada By Leslie A. Pal; R. Kent Weaver Georgetown University Press, 2003 Read preview Overview FREE! The Lives of James Madison and James Monroe: Fourth and Fifth Presidents of the United States By John Quincy Adams Phillips, Sampson, 1850 Read Overview The Law: When Law and Politics Collide: Presidents and the Use of the Twenty-Fifth Amendment By Kassop, Nancy Presidential Studies Quarterly, Vol. 35, No. 1, March 2005 PRPEER-REVIEWED PERIODICAL Peer-reviewed publications on Questia are publications containing articles which were subject to evaluation for accuracy and substance by professional peers of the article's author(s). Read preview Overview What Presidents Talk About: The Nixon Case By Jacobs, Lawrence R. Page, Benjamin I. Burns, Melanie McAvoy, Gregory Ostermeier, Eric Presidential Studies Quarterly, Vol. 33, No. 4, December 2003 PRPEER-REVIEWED PERIODICAL Peer-reviewed publications on Questia are publications containing articles which were subject to evaluation for accuracy and substance by professional peers of the article's author(s). Read preview Overview Source Material: Presidents and Polling: Politicians, Pandering, and the Study of Democratic Responsiveness By Shapiro, Robert Y. Jacobs, Lawrence R. Presidential Studies Quarterly, Vol. 31, No. 1, March 2001 PRPEER-REVIEWED PERIODICAL Peer-reviewed publications on Questia are publications containing articles which were subject to evaluation for accuracy and substance by professional peers of the article's author(s). Read preview Overview Thou Shalt Not Mix Religion and Politics: My Sunday Sermon at the 'Church of the Presidents' By Lynn, Barry W. Church & State, Vol. 61, No. 2, February 2008 Read preview Overview Which Presidents Went to Harvard? By Mendoza, Sylvia The Hispanic Outlook in Higher Education, Vol. 30, No. 11, August/September 2020 Read preview Overview Judqe Finds Two Presidents Guilty: Political Commentator Judge Andrew Napolitano's New Book Explains How Presidents Theodore Roosevelt and Woodrow Wilson Led the Charge in Undermining the Constitution By Kenny, Jack The New American, Vol. 29, No. 2, January 21, 2013 Read preview Overview Rating the Presidents after Taft By Wilezol, David The Washington Times (Washington, DC), February 8, 2012 Read preview Overview In a Gathering of Presidents, a Model for Washington By the Monitor's Board The Christian Science Monitor, April 25, 2013 Read preview Overview Vice Presidents Get Day in Print By Lehner, Jennifer The Washington Times (Washington, DC), July 11, 2004 Read preview Overview VIEW ALL RELATED BOOKS AND ARTICLES


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i was wondering what would be the best dvd authoring software any suggestions would be greatly appreciated
sonic mydvd
pinnacle instant cd/dvd
ulead dvd workshop
sony dvd architect
any more besides those??
TDA (TMPGEnc DVD Author), very capable and popular with video enthusiasts.
DVDLab, a bit more advanced.
Adobe Encore
Sonic DVD author
and many more
I like Sony DVD Architect, and Nero.
I stated Adobe encore above and IMO it is a good piece of software. Overall for ease of use and good output I would have to say Tmpgenc dvd Author and Ulead movie factory. I use different applications depending on what I want my end result to be. Pick one of the above and get to learn it and add onto that as you progress.
I have'nt tried Adobe Encore, but I am going to see if they have a trial available, if so, Im going to give it a shot…
Peace and Luv,
DJ Mind
i have nero but how do i author on that?
Try NeroVision Express
Peace and Luv,
DJ Mind


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Parallel Verses
New American Standard Bible
Pilate said to them, "You have a guard; go, make it as secure as you know how."
King James Bible
Pilate said unto them, Ye have a watch: go your way, make it as sure as ye can.
Darby Bible Translation
And Pilate said to them, Ye have a watch: go, secure it as well as ye know how.
World English Bible
Pilate said to them, "You have a guard. Go, make it as secure as you can."
Young's Literal Translation
And Pilate said to them, 'Ye have a watch, go away, make secure -- as ye have known;'
Matthew 27:65 Parallel
CommentaryBarnes' Notes on the Bible
Ye have a watch - The Jews had a guard of Roman soldiers, who kept watch in the tower of Antonia, on the northwest of the temple. Pilate either referred to these, or to the "watch" that attended the crucifixion - the whole "band" that had been appointed for that. As the torments of crucifixion sometimes lasted many days, the band had been probably granted to them during that time, and they were therefore still at the direction of the chief priests.
Matthew 27:65 Parallel Commentaries
LibraryThe Sentence which Condemned the Judges
And Jesus stood before the governor: and the governor asked Him, saying, Art Thou the King of the Jews? And Jesus said unto him, Thou sayest. 12. And when He was accused of the chief priests and elders, He answered nothing. 13. Then said Pilate unto Him, Hearest Thou not how many things they witness against Thee? 14. And He answered him to never a word; insomuch that the governor marvelled greatly. 15. Now at that feast the governor was wont to release unto the people a prisoner, whom they would. …
Alexander Maclaren—Expositions of Holy Scripture
Taunts Turning to Testimonies
Remorse and Suicide of Judas.
The Crucifixion.
Cross References
Matthew 27:64
"Therefore, give orders for the grave to be made secure until the third day, otherwise His disciples may come and steal Him away and say to the people, 'He has risen from the dead,' and the last deception will be worse than the first."
Matthew 27:66
And they went and made the grave secure, and along with the guard they set a seal on the stone.
Matthew 28:11
Now while they were on their way, some of the guard came into the city and reported to the chief priests all that had happened.
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