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Great post and right on target. I found that if you blog and/or do videos that sharing little stories will help connect you to potential leads. I do how-to videos and posts and I always tell personal stories or my own experiences that relate to the subject. It works and I get personal messages from people about it. It makes you more real and down to earth in the viewer's eyes. Once they like you and trust you they will become a lead and hopefully a sale. They may very well become a regular buyer because you will be their go to person. For best results it's best to blog daily and do at least one video a day.
What is the most utilized social channel for 2019? It's Youtube. With Internet connections becoming faster than before and computer hardware becoming more advanced, people are now moving towards videos as a primary form of content. This is the reason why it is better to promote your affiliate products on video. In this course, you will learn how you can make a passive income posting affiliate videos online. Once you become good at it, you may even create your very own empire. This one is not a scam and really goes into the best details.
One way to promote your affiliate link is through classified ads and it is more effective than you think. You may think that it is a form of spamming. But this is not about that. It is about crafting your ads in a way that will encourage the prospects to visit your affiliate site. In this course, you'll learn all about this and how you can have an income promoting affiliate offers on classifieds. This is a real case study on how the mentor actually did it.
Did you know that you can make money promoting Apple iTunes? iTunes has an affiliate program that is free to join. With this, you can promote all their products and get a commission in return. This course will show you the exact details of this path. The iTunes affiliate program has different levels that you have to consider when joining. This course will show you what you need to do in order to qualify for each level. This course touches on keyword research.
Focus on reviewing products and services that fall within your niche. Then, leveraging the rapport you have created with your audience and your stance as an expert, tell your readers why they would benefit from purchasing the product or service you are promoting. Almost anything sold online can be reviewed if there is an affiliate program – you can review physical products, digital software, or even services booked online, like ride-sharing or travel resort booking. It is especially effective to compare this product to others in the same category. Most importantly, make sure you are generating detailed, articulate content to improve conversions.
An e-commerce merchant wanting to reach a wider base of Internet users and shoppers may hire an affiliate. An affiliate could be the owner of multiple websites or email marketing lists; the more websites or email lists that an affiliate has, the wider his network. The hired affiliate then communicates and promotes the products offered on the e-commerce platform to his network. The affiliate does this by implementing banner ads, text ads, or links on its multiple owned websites or via email to its clientele. Firms use advertisements in the form of articles, videos, and images to draw an audience's attention to a service or product.
Jerry is a young aspiring Internet Entrepreneur who started his online business at the age of 18. He is currently a Full-time Affiliate Marketer at Wealthy Affiliate, a community to help anyone start their own online business without prior experience. He actually achieved Financial Independence at the young age of 21. Read more about his story here!
You may have heard a lot about Bitcoin in the past year. Many people have talked about it thinking that it is the next prime currency. Regardless of what people think, it is a money making machine for many. And that includes affiliates. You see, you can promote certain bitcoin wallets and exchanges and make some money in return. All you need to do is promote it. In this course, you'll learn all about that. More than learning about Bitcoin, you'll learn how you can become a successful bitcoin affiliate.
For a slightly different take on the subject and figuring out how to get targeted traffic onto your promoted links, you must have a look at Affiliate Marketing: Instant Traffic to Affiliate Links. A quick look at the reviews will help you decide if this is the exact course you are looking for. Sometimes the right approach is what is required to make a campaign work, this one might just work for you.
Unscrupulous affiliates can squat on domain names with misspellings and get a commission for the redirect. They can populate online registration forms with fake or stolen information, and they can purchase AdWords on search terms the company already ranks high on, and so on. Even if the terms and conditions are clear, an affiliate marketing program requires that someone monitor affiliates and enforce rules.
It's not the one that'll give me the highest commission, but this is the best value to you: the end user. Join a community of 2 Million+ Affiliate marketers. Follow the trail of industry-leading success. Get a free WordPress website, 10 Modules of the Online Entrepreneur Certification, and 7 days of coaching via messaging without entering billing info. Test drive what it's like to be an affiliate marketer at no risk.
If you are interested in learning the process behind building a WordPress website then you should look at Learn how to Build High Quality Affiliate Websites. This will help you not just learn how to promote but also get you going with setting up the wordpress website and then promote relevant products. Andrew's course is a Bestselling Course and we have no doubts why. The following pointers should help you make up your mind. Think of this program like going to affiliate marketing school.
Be sure to check what kind of customer support you can expect from your affiliate program once you have signed up. Do your research online and if possible, speak to other sellers using the program to get their thoughts. Can you speak to someone via phone or Skype or do you have to wait 72 hours for email responses? Be clear on this because trust me, you will need support at one point or another.
Loaded with more than 5.5 hours of video, seven downloadable resources, and two articles, this course has more than 7,000 students benefiting from it. This course will teach you the same steps that entrepreneurs and startups use to build & grow their business. By the end of this course, you'll have an ever-growing list of articles and products that you can monetize at will. Each stage of the course covers in-depth a particular aspect of setting up your affiliate business.
This domain can work for people in two ways. One is to get sudden bursts of income by selling a certain product. The second part is selling a service that gives you recurring fees. This course on Affiliate Marketing Strategy for Stable and Recurring Income can be very helpful if your objective is the latter. At 5.5 hours and 56 lectures, this is very extensive and useful for those looking at mastering this subject. This training program is developed by iMarket XL and Max Stryker.
Hi my name is prince and I am interested in affiliate program but I already registered with an affiliate company called markethealth.com. do I continue with by marketing their products online and thereby generating profits?..secondly am still not clear on how I can generate traffic to my Twitter account while affiliating for markethealth.com..thankyou..awaiting your reply
The Instructor, Theo McArthur is an entrepreneur, amazon seller, investor as well as expert online marketer. Having been working on this domain since 1995, she now truly enjoys helping others learn life changing techniques and business models. Having created numerous 'authority' blogs to promote affiliate products over the years, she is perfectly placed to teach you the tricks involved in kick starting and enhancing your affiliate business. Along with all this, she's also been selling stuff on Amazon and runs her own e-commerce venture. All in all, this is as much experience as you can ever wish for in a trainer. Hope you are able to make the most of this training program.
After completing all the training modules in this Affiliate marketing course, you will be able to create landing pages, profitable ads, and learn what language to write to be accepted in even the most difficult to enroll affiliate programs with high commissions but an equally high rejection rate. This four-hour video and five articles course, however, requires you to have excellent English comprehension skills.
The Sandals affiliate program pays you a commission for referring users to book either a stay in one of the Sandals Resorts, or booking an activity. While 4% might seem like a small percentage, these luxury resorts have daily rates that range from $150 to over $2,000 per person -- which means, if a couple were to book a romantic week in a Sandals Resort at $500 per person per night, you would earn a commission of $280!
I must thank you for putting together such a wonderful course; it's really an eye opener! There were issued you touched on and properly explained that I've never come across before. I will be on the look out some more of your great courses; thank you very much. As a matter of fact, I just love that fact that I have to course with me and go back to it to find ideas when I need to use them; thank you once again
Advertising has always been an issue for new affiliate marketers. Many have tried to do it and ended up losing money instead. Here's the thing. It is useless to spend hundreds or thousands of dollars on advertising if you are not going to earn it back. And most people who don't know what they are doing don't earn it back. When that happens, they quit. Don't let this happen to you. Let this course show you that you can be a successful affiliate marketer without the cost of advertising. If you are doing Internet marketing then this course will show you how to build the best authority site.
One of the things that you should explore as an affiliate marketer is Amazon. Amazon allows you to become an affiliate. With it is the permission to sell their items for a commission. While this may sound great, it can be quite hard to do especially when you are starting out. You see, you are only one of the millions of affiliates that Amazon has. This means that you have to compete against all of these people. Fortunately, there is a way for you to stand out. In courses like these, you'll learn how to be on top of your game when it comes to Amazon Affiliate marketing.
Howard Murad, M.D. has devoted his life to the science of skincare, and is one of the country's top skincare authorities. After treating individuals with various skin concerns, he began developing targeted formulas to treat skin conditions. Today, Murad is one of the leading companies in skincare products, and is popular for its treatments for acne, anti-aging, cellulite, age spot treatments, and more.
Affiliate marketing courses is great because you can promote anything, even if you don't have your own product or website. This course takes you inside Clickbank to get to know the types of products that you can sell and how you can sell it fast. This is perfect for beginners who are still looking for a course where they can learn the basics of affiliate marketing and how to become a wealthy affiliate marketer. It is also good for beginner affiliate marketers who are budget-conscious or those people who don't want to go through the trouble of buying a domain and hosting when they don't know what they are doing. This course will help you improve your digital marketing and ultimately you will do better with Google.
There was a lot of helpful information in this course. This course is perfect for beginners and more advanced learners as well. I was able to learn more about SEO and incorporate the techniques used here on my website. I am looking forward to a better earning potential with the techniques I have learned here. I also truly appreciate the free giveaways that are given upon completion of this course. It's absolutely astonishing with the amount of resources you receive with taking this course.
This is the standard affiliate marketing structure. In this program, the merchant pays the affiliate a percentage of the sale price of the product after the consumer purchases the product as a result of the affiliate's marketing strategies. In other words, the affiliate must actually get the investor to invest in the product before they are compensated.


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We Searched 11 hot Adidas jeans over the last 3 years. Find which Adidas jeans is best for you. You can also Filter by style, size type, inseam and material or settle upon one of our Adidas jeans feature picks.
Opting for an Adidas jeans can be entangling. With so many Adidas properties, selections, styles, jeans sizes, colors all of which pretend to be essential. At Jeansn.com we we make an effort to make it effortless to zero in on precisely what Adidas jeans you covet.

subset: commoncrawl


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Joseph Olgin of CENTURY 21 Gold Standard
p: 716.689.4000
m: 716.969.6831
Joseph Olgin
As an accomplished athlete and scholar, Joseph's experiences make him an invaluable asset as a Realtor. Through earning a master's in physical education and biking thousands of miles through forty-seven states, Joseph demonstrates the perseverance needed to negotiate winning deals in today's fast-paced and competitive real estate market. Specializing in coaching home buyers, sellers, and investors, Joseph is the ideal partner for those seeking to cross the finish line in their real estate endeavors.
Read More Read Less


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The US-based National Institute on Aging is giving $3.8 million to top researcher Dr. Mariana Figueiro, professor and director at the Lighting Research Center (LRC) at Rensselaer Polytechnic Institute in New York state. The institute wants Figueiro to probe if installing so-called 'circadian lighting' for elderly people can improve sleep, perception and memory. It especially wants to see if it helps individuals with mild cognitive impairment, which is a potential early stage of dementia. Figueiro is among the world's top experts in the area of light and health, with a focus on bridging science to practical applications aimed at improving human quality of life. https://www.lrc.rpi.edu/
Record Grant for Scientists to Study Light and Health
Posted in Industry News


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text:
Original Title: Die Muskeltiere und das Weihnachtswunder
With illustrations from Ute Krause
original edition
Recommended age group: 8 +
Hardcover, 192 pages, 17.0 x 24.0 cm, 6.7 x 9.4 in.
€ 15.00 [D] | € 15.50 [A] | CHF 21.90 * (* rec. retail price) recommended retail price
Publishing House: cbj Kinderbücher
Date of publication:
September 30, 2019
This title is available.
Kundenrezensionen: (7)
"a beautiful detective story about courage, trust, the message of Christmas and the savoury smell of gingerbread."
Mecklenburger Blitz
"The thrilling thief hunt among cinnamon stars and gingerbread house makes you long for lots of Christmasb sweets."
NRZ (Neue Ruhr / Neue Rhein Zeitung)
"Colourful, original, amiably told and illustrated and with a full load of advent atmosphere between its covers. […] An absolute recommendation from the heart."
Gelnhäuser Neue Zeitung
"It brings suspense, atmosphere and maybe even quiet to families"
rbb Kulturradio
"This is exactly how a great Christmas adventure has to be […] An absolute heart-felt recommendation."
rbb Kulturradio
"Exciting moments, sweet illustrations, social criticism, wit and a bit of romance […]. Great!"
"An exciting and enchanting reading adventure, narrated with imagination and wit."
Badische Zeitung
© Penguin Random House Verlagsgruppe GmbH
Weiter zu www.penguinrandomhouse.de


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Auto racing roundup -- Sharp's team gets 1-2 finish in P2 class at Long Beach
Recommended Video:
Barely two months after making the switch from the GT class to P2, Scott Sharp and his Extreme Speed Motorsports team scored a 1-2 finish in class at Saturday's American LeMans Series event at Long Beach.
Team owner Sharp, who grew up in Wilton, and Guy Cosmo, co-drivers of the No. 01 HPD ARX-03b, won the evnt with Ed Brown and Johannes van Overbeek finishing second in P2 aboard the No. 02 Tequila Patrón HPD ARX-03b.
It was the first 1-2 finish in ESM history; Cosmo got his first win in ESM livery, and Brown and van Overbeek recorded their first podium finishes in P2 competition.
"This is hurge. The team has done an amazing job with the transition to P2," said Sharp, recognizing that the Extreme Motorsports not only switched classes, but also made the transition from Ferrari 458i GT cars to the purpose-built Honda Performance Development P2 vehicles.
The Sharp-Cosmo entry finished sixth overall in the 30-car ALMS field at Long Beach, one lap behind the winning P1 entry driven by Klaus Graf and Lucas Luhr. Brown and van Overbeek placed eighth overall.
"It felt great taking the checkered flag today," Sharp said Saturday. "Honestly, this win came a little quicker than I thought it was going to."
Cosmo started the No. 01 in the two-hour event in second place among P2 entries. He quickly took the lead and held it until Sharp climbed into the cockpit during a yellow flag pit stop.
After a slight delay in the pits, Sharp went two laps before another caution slowed the field. Sharp pitted for a splash of fuel, which was enough to assure they could go the distance.
Brown had a strong opening stint in the No. 02. He started the race in fourth and gained a position before turning the car over to van Overbeek, just after the 40 minute mark.
During his stint, van Overbeek worked his way from third to first and led the P2 class at one point.
Next on the schedule for the Extreme Speed Motorsports is the American Le Mans Monterey scheduled for May 9-11.
LaJoie back in seat
Corey LaJoie will return to the NASCAR K&N East wars Thursday night at Richmond International Raceway.
The third-generation driver who led the series with five wins in 2012 has not driven a K&N car since the Feb. 19 non-points Battle at the Beach at Daytona.
After sitting out three races, he is entered at Richmond in the family-owned No. 07 Ford. He has third-place finishes in his last twos starts at the 0.75-mile Virginia facility.
The race is the first of a busy weekend at Richmond. The Nationwide Series runs Friday night and the NASCAR Sprint Cup series on Sunday.
Parker Kligerman of Westport, in his first season as a NNS regular in the No. 77 Toyota fielded by Kyle Busch Motorsports, is sixth in the series standings.
Rocc-king at Waterford
Keith Rocco won his second feature of the season in SK modified action at the Waterford Speedbowl Saturday night. Ted Christopher, who plans to run the 'Bowl as often as his NASCAR modified tour schedule permits, was second.
Other winners at the shoreline speedplant were Jeff Smith (late model), Allen Coates Sr. (street stock), Garrett Denton (mini stock) and Randy Churchill (SK light). Alan Benincaso of Westport was fifth in the 25-lap SK light feature.
The New England Truck Series joins five regular divisions on the Speedbowl card this Saturday.
Mod tour at Stafford
The NASCAR Whelen Modified Tour will run event No. 2 in its 14-race schedule this weekend at Stafford Motor Speedway. The two-day event culminates with the 200-lap Spring Sizzler for the modified tour.
Seven-time series champ Mike Stefanik won the opener April 14 at Thompson. Norwalk's Ron Silk, the 2011 champ, was in the hunt at 'The Big T' aboard the TS Haulers No. 6 and finished fourth.
Rowan Pennink was second at Thompson and won Saturday night's Valenti Modified Racing Series 100-lapper at Monadnock Speedway.
Doug Coby won last year's Sizzler and won three of the four WMT events contested at Stafford on his way to the 2012 series crown.
Also on the weekend card at Stafford are the SK modifieds, late models, SK lights, limited late models, DARE stocks and Northeast Mini Stock Tour.
Doin' it in the dirt
Michael Ruttkamp of Wilton was 15th in Saturday night's 410 sprint feature at Port Royal Speedway. He finished fourth in his heat race.
Brett Hearn won his second straight big block modified feature at Lebanon Valley, again beating Ken Tremont Jr. Eddie Marshall of Ridgefield was eighth. Rob Yetman (pro stocks) and Tyler Dippel (budget sportsman) also claimed checkered flags.
At Orange County Fair Speedway, Jeff Hoetzler (modifieds), Gary Edwards Jr. (358 modifieds), Joe Conklin (sportsman) and Charlie Donald (street stock) were the winners.
Stephen Kammer of Ridgefield, the opening night winner, was second in the street stock main.


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LOWEST PRICED 3 BR, FULL BASEMENT HOME IN WESTSHORE! About 2,450 SQFT, large rooms, big decks, quiet street. Full height basement perfect for a suite w/ bath roughed in. Level fenced 7,500 SQFT lot, in area of new homes. House is rundown, deferred maintenance throughout, hence low price. Use "purchase plus improvements," mortgage to install a top-notch suite & to upgrade this home - live here net of suite income for approximately $1,000 per month OAC. A money-maker! Cooperative sellers, easy to show. Bring your offer, bring your paint brush, earn sweat equity in this home. Why buy someone else's old house for more money? Make this one shiny & new, done right to your taste. The fixer-upper you've been looking for. Call today!


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A term that originated thanks to America's booming fitness industry in the 70s — think 'Pumping Iron' — today, Athleisure has grown past dour velour tracksuits, neon headbands, and risque men's athletic shorts. These days, you can find men and women across the world dressed in chic hoodies, trendy joggers, and funky tops and t-shirts, whether they're at the gym, hanging out with their buds, and even at work!
But can you make this look work for you? Read on to find out how you can make your gym gear suitable for everything from a high-powered work day to an evening of extreme chilling.
Working — Out & In
With flexible work hours and adaptable workspaces becoming the norm, relaxed workwear can't possibly be far behind. On those days when your workout stretches on for too long and you need to get to work 'ASAP', go ahead and match your brown chinos with a patterned, crew cut t-shirt to create a sporty but professional look. If you're feeling really adventurous, you can always kick it up a notch by giving your chinos a cuff and pairing them with a nice set of low-rise sneakers (Stan Smiths, I've got my eyes on you). The best part of it all is that this look works regardless of the weather — throw on a bomber jacket when the mercury plummets, or sit back and relax as your t-shirt's sweat-wicking fabric keeps you cool as a cucumber in the summer heat.
A word of advice though, unless you work in a start-up or in the creative field, its always best to have a set of formal clothes at hand for meetings or when you want your attire to be a little more professional.
Hanging Out/Staying In
When you're out on the town with your friends and looking to make heads turn, athleisure is what you need in your life. Couple funky joggers — in red, green, or yellow (if, and only if, you can pull it off) with a crew neck jumper or sweater to create that just-off-the-track vibe. You can take this look even further by pairing a cap or beanie with your favourite sports team's emblem on it. As usual, sneakers are your best friends and and a pair of Jordans will go a long way in completing this look for you.
Of course, if you're going out on a hot summer day and feel like you'd probably sweat to death under all those layers, don't fret. You can also stand out in a pair of boardshorts with a well-fitted tee, as long as you make sure to accessories it with a cool pair of shades and some light espadrilles.
Whether its for work or for funsies, athleisure can take your look from 0 to 100 — while still being flattering, comfortable, and unique. Choose from Jockey's wide variety in the athleisure series and get ready to play, relax, or just do nothing.
A term that originated thanks to America's booming fitness industry in the 70s — think 'Pumping Iron' — today, Athleisure has grown past dour velour tracksuits, neon headbands, and risque men's


text: To reach Lerner Barry M please call them at (201) 653-3701. You can also visit their location at 3 Sherman Pl Jersey City in Newark. The contact information for Lerner Barry M is found below. If this is incorrect please click the "SEND" button to let us know. Are you the owner of this business? Do you know you can upload a video of Lerner Barry M for free to help promote it? If you have visited Lerner Barry M and want to share your experience with the business please write a review! To view a larger map and get driving directions to Lerner Barry M found at 3 Sherman Pl Jersey City in Newark please scroll down and click the link below.


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Drug Discovery and Drug Development
Drug development now is a highly complex, tedious, competitive, costly and commercially risky process. From the synthesis/identification of the molecule to marketing, a new drug takes at least 10 years and cost of 500-1000 million US $.
Stages in New Drug Development –
Broadly, the process can be divided into three main components.
1. Drug Discovery :
During which candidate molecules are chosen on the basis of their pharmacological properties.
2. Preclinical Development :
3. Clinical Development :
The Drug Discovery Phase
1. Target Selection (choosing a molecule to target with a drug)
A "target is produced within the pharmaceutical industry. Generally the "target" is the naturally existing cellular or molecular structure involved in the pathology of interest. Where the drug-in-development is meant to act.
- The target may be a protein molecule, enzyme, transport molecule, Ion channel, Tubulin, Immunophilin, which is involved in particular disease.
- Even at this early stage in drug discovery it is critical that researches pick a target that is "drugable", I.e., One can potentially interact with and be affected by a drug molecule.
2. Lead Finding (Finding a promising molecule [a "lead compound"] that could become a drug)
It involves cloning of the target protein-normally the human form, because the sequence variation among species is often associated with pharmacological differences and it is essential to optimize for activity in humans.
- Compounds obtained from plants, animals or marine organisms are much more troublesome to produce commercially.
- The main disadvantage of natural products as lead compounds is that they are often complex molecules that are difficult to synthesize or modify by conventional synthetic chemistry, so that lead optimization may be difficult and commercial production very expensive.
3. Lead Optimization (Alter the structure of lead candidates to improve properties)
Lead compounds found by random screening are the basis for the next stage.
- Lead compounds that survive the initial screening are the "optimized" or altered to make them more effective and safer (increase the potency)
- In this phase, the tests applied include a broader range of assays on different test systems, including studies to measure the activity and time course of the compounds in vivo and checking the unwanted effects in animals, evidence of genotoxicity and usually for oral absorption.
The objective of the lead optimization phase it to identify one/more drug candidates suitable for further development.
Even at this early stage, researchers begin to think about how the drug will be made, considering formulation (the recipe for making a drug, including inactive ingredients used to hold it together and allow it to dissolve at the right time), delivery mechanism (the way the drug is taken – by mouth, injection, inhaler) and large-scale manufacturing (how you make the drug in large quantities).
Pre-clinical Development (Lab and animal testing to determine if the drug is safe enough for human testing)
- Pre clinical studies assess the safety of the molecule prior to the drug administration into the human body.
- Pre Clinical studies can be studied on animals and in vitro where in animal studies, we use species namely rodents (rats, mice) and non rodents (rabbit, guinea pig)
Note :
– Vivo = life (latin)
– Vitro = Glass (latin)
The aim of preclinical development is to satisfy all the requirements that have to be met before a new compound is deemed ready to be tested for the first time in humans. The work falls into four main categories:
- Pharmacological testing to check that the drug does not produce any obviously hazardous acute effects such as bronchoconstriction, cardiac dyshythmias, blood pressure changes and ataxia. This is termed safety pharmacology.
- Preliminary toxicological testing to eliminate genotoxicity and to determine the maximum non-toxic dose of the drug (usually when given daily for 28 days, and tested in two species). As well as being checked regularly for weight loss and other gross changes, the animals so treated are examined minutely post mortem at the end of the experiment to look for histological and biochemical evidence of tissue damage.
- Pharmacokinetic testing, including studies on the absorption, metabolism, distribution and elimination (ADME studies) in the species of laboratory animals used for toxicology testing, so as to link the pharmacological and drug exposure.
- Chemical and pharmaceutical development to assess the feasibility of large-scale synthesis and purification, to asses the stability of the compound under various conditions and to develop a forumulation suitable for clinical studies.
When a compound deserving trial in man is identified by animal studies, the regulatory authorities are approached who on satisfaction issue an 'investigational new drug' (IND) licence. The drug is formulated into a suitable dosage form and clinical trails are conducted in a logical phased manner. To minimize any risk, initially few subjects receive the drug under close supervision. Later, larger numbers are treated with only relevant monitoring. Standards for the design, ethics, conduct, monitoring, auditing, recording and analyzing data and reporting of clinical trails have to be laid down in the form of 'Good clinical Practice' (GCP) guidelines by an 'International Conference on Harmonization' (ICH).
GLP covers aspects like record-keeping procedures, data analysis, instrument calibration and staff training. The aim of GLP is to eliminate human error as far as possible, and to ensure the reliability of the data submitted to the regulatory authority, and laboratories are regularly monitored for compliance to GLP standards. The strict discipline involved in working to this code is generally ill-suited to the creative research needed in the earlier stages of drug discovery, so GLP standards are not usually adopted until projects get beyond the discovery phase.
Roughly half the compounds identified as drug candidates fail during the preclinical development phase; for the rest, a detailed dossier (the 'investigator brochure') is prepared for submission along side specific study protocols to the regulatory authority such as the European Medicines Evaluation Agency or the US Food and Drugs Administration, whose permission is required to proceed with studies in humans. This is not lightly given and the regulatory authority may refuse permission or require further work to be done before giving approval.
Non-clinical development work continues throughout the clinical trails period, when much more data, particularly in relation to long-term and reproductive toxicity in animals has to be generated. Failure of a compound at this stage is very costly, and considerable efforts are made to eliminate potentially toxic compounds much earlier in the drug discovery process by the use of in vitro, or even in silico, methods.
Clinical Development
Phases 0 Trail :
Phase – 1 : Human Pharmacology and Safety
Phase – 2 : Therapeutic exploration and dose ranging
Phase 2 studies are performed on groups of patients (normally 100-300) and are designed to determine pharmacodynamic effect in patients and if this is confirmed to establish the dose regimen to be used in the definitive phase 3 study. Often, such studies will cover several distinct clinical disorders (e.g. depression, anxiety states and phobias) to identify the possible therapeutic indications for the new compound and the dose required. When new drug targets are being studied, it is not until these phase 2 trials are complted that the team finds out whether or not its initial hypothesis was correct, and lack of the expected effect is a common reason for failure.
Phase – 3 : Therapeutic confirmation/comparison
Phase 3 studies are the definitive double-blind, randomized trials, commonly performed as multicentre trials on thousands of patients, aimed at comparing the new drug with commonly used alternatives. These are extremely costly, difficult to organize and often take years to complete, particularly if the treatment is designed to retard the progression of a chronic disease. It is not uncommon for a drug that seemed highly effective in the limited patient groups tested in phase 2 to look much less impressive under the more rigorous conditions of phase 3 trials.
At the end of phase 3, the drug will be submitted to the relevant regulatory authority for licensing. The dossier required for this is a massive and detailed compilation of preclinical and clinical data. Evaluation by the regulatory authority normally takes a year or more, and further delays often arise when aspects of submission have to be clarified or more data are required. Eventually, about two-thirds of submissions gain marketing approval. Overall, only 11.5% of compounds entering Phase 1 are eventually approved. Increasing this proportion by better compound selection at the laboratory stage is one of the main challenges for the pharmaceutical industry.
Phase 4 – Post marketing surveillance/studies
Phase 4 studies comprise the obligatory post marketing surveillance designed to detect any rare or long-term adverse effects resulting from the use of the drug in a clinical setting in many thousands of patients. Such events may necessitate limiting the use of the drug to particular patient groups, or even withdrawal of the drug.
Uncommon/idiosyncratic adverse effects, or those that occur only after long-term use and unsuspected drug interactions are detected at this stage. Patterns of drug utilization and additional indications may emerge from the surveillance data.
Further therapeutic trials involving special groups like children, elderly, pregnant/lactating women, patients with renal/hepatic disease, etc. (which are generally excluded during clinical trials) may be undertaken at this stage. Modified release dosage forms, additional routes of administration, fixed dose drug combinations, etc. may be explored.
As such, many drugs continue their development even after marketing.
Goal: Understand the disease and choose a target molecule.
How: Scientists in pharmaceutical research companies, government, academic and for-profit research institutions contribute to basic research.
Goal: Find a drug candidate.
How: Create a new molecule or select an exxisting molecule as the starting point. Perform tests on that molecule and then optimize (change its structure) it to make it work better.
Goal: Test extensively to determine if the drug is safe enough for human testing.
How: Researchers test the safety and effectiveness in the lab and in animal models.
Goal: Obtain FDA approval to test the drug in humans.
How: FDA reviews all preclinical testing and plans for clinical testing to determine if the drug is safe enough to move to human trials.
Clinical Trials
Goal: Test in humans to determine if the drug is safe and effective.
How: Candidate drug is tested in clinical setting in three phases of trials, beginning with tests in a small group if healthy volunteers and moving into larger groups of patients.
Goal: FDA reviews results of all testing to determine if the drug can be approved for patients to use.
How: The FDA reviews hundreds of thousands of pages of information, including all clinical and preclinical findings, proposed labeling and manufacturing plans. They may solicit the opinion of an independent advisory committee.
Goal: Formulation, scale up and production of the new medicine.
Ongoing studies
Goal: Monitor the drug as it is used in the larger population to catch any unexpected serious side effects.
- Essenetials of medical pharacology – KD Tripathi
- Rang and Dale's Pharmacology
- Innovation / inside R and D


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This Otherworldly Historic Garden In Houston Is Actually A Beautiful Cemetery Locals Love
There's even great views of downtown.
When you think of getting outdoors and visiting a tranquil place, visiting a park or a nature preserve is probably what comes to mind. While these are great getaways, there are other, more unique ways to get outdoors. There's a beautiful garden cemetery in Houston worth exploring that is one of the prettiest outdoor places in town.
Glenwood Cemetery near Downtown Houston is an incredibly pristine and surprisingly tranquil place to visit.
It's so close to downtown that you can look up and see the skyscrapers stretching into the air as you're wandering around the perfectly kept lawns.
The cemetery is old but it has an even more historic air to it because it was designed in the 19th-century style of romantic rural parks.
So although you can see skyscrapers from the cemetery, it feels as if you're in a picturesque countryside in the 1800s.
You can visit the meticulously kept grounds every day from 7 a.m. to 5 p.m., and during daylight savings, the gates are kept open until 5:30 p.m.
Glenwood also offers tours if you really want to get to learn more about the history of the beautiful cemetery.
Wandering around the different well-kept and intricate mausoleums and tombstones is a unique way to get outside now that the weather is getting warmer soon.
The cemetery is so serene that while strolling through the regal sculptures and monuments, it can be easy to forget that this is the final resting place for some Houstonians.
However, it's really important to keep this in mind and make sure your visit to the cemetery is respectful of those who were laid to rest there.
Glenwood Cemetery is so hauntingly beautiful, with its bright greenery and stunning architectural pieces, you definitely should stop by for a calm and respectful stroll sometime.
The cemetery is a part of Houston that feels like it's from another country and era but is surprisingly one of the most peaceful spots in this big city.
Glenwood Cemetary
Price: Free
Address: 2525 Washington Ave., Houston, TX
Why You Need To Go: One of the prettiest places in Houston happens to be this historic cemetery and the grounds look straight from the Romantic era.
We strongly advise that before you go swimming or visit any location, you check the most recent updates on potential hazards, security, water quality, and closures. If you do plan to visit a location, respect the environment.


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Very nice parka, hardly used, rayon/cotton shell with wool blanket lining. Nice colors, very cool mismatched waist tie. I replaced the buttons with nice quality reproductions.I also added the "X" stitching, in original field grey linen thread, on the back to hold the ties in place and to keep them from pulling out. A common feature on originals. The item "WW2 SMW Fall Oak Parka Camo Camouflage Wholesale WWII" is in sale since Friday, July 31, 2020.
This item is in the category "Collectibles\Militaria\WW II (1939-45)\Reproductions\Germany". The seller is "wade03" and is located in Bath, North Carolina. This item can be shipped to United States.


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A thriving piece of coral the size of the Empire State Building was discovered in Australia
The Great Barrier Reef in Australia is home to more than 1,500 species of fish, 411 species of coral, along with dozens of other species. But since 1995, it's lost more than half of its corals due to warmer waters and climate change. Recently, one of those pieces of coral has been found. And it's big. It's 1,600 feet tall, to be exact, making it taller than the Empire State Building.
Not only that, but the coral is healthy and thriving. The coral has a healthy ecosystem and a "blizzard of fish," lead scientist Dr. Robin Beaman said per Reuters. "We are surprised and elated by what we have found."
Even better, the coral didn't show any evidence of damage, even though the section of the Great Barrier Reef it was found in experienced bleaching in 2016. Bleaching happens when the water gets too warm, which causes the coral to expel living algae then calcify and turn white.
- Half of the Great Barrier Reef's coral is gone. It might never recover ... ›
- Great Barrier Reef Australia - Coral Facts - Barrier Reef Australia ›
- Great Barrier Reef - Wikipedia ›
- Great Barrier Reef biobank design reveals future for global coral ... ›
- The Great Barrier Reef Has Lost Half Its Corals - The New York Times ›
- Australian scientists discover 500-meter-tall coral reef in the Great ... ›
- Scientists discover 500 metre-tall skyscraper coral reef at Australia's ... ›
- Great Barrier Reef has lost half of its corals since 1995 - BBC News ›
- The Great Barrier Reef has lost half its corals | CNN Travel ›


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Antique Vibrant Italian Micro Mosaic Brooch
Product Description
Enchantingly vibrant and colorful micro mosaic brooch. Elongated, horizontal oval features an array of different floral motifs and patterned framing. Brass setting. Made in Italy. Antique and authentic. Circa unknown.
Circumference: 4.25 inches
Length: 1.25 inches
Width: 1.5 inches
It is in excellent condition. Please check the measurements carefully before purchasing. It is clean and ready to wear.
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Chicken Mozzarella Pasta with Sun-Dried Tomatoes
Slice tomatoes into smaller pieces and add them back to skillet with chicken. Add the half and half and cheese to skillet and bring to a slow boil. Reduce to simmer and cook, stirring constantly until cheese melts and creamy sauce forms. Add cooked pasta to skillet with the sauce and stir to combine. Add 1 tablespoon of basil, and at least 1/4 teaspoon of red pepper flakes. Stir to combine. Add about 1/2cup of reserved pasta water as sauce may be too thick.This will make it creamier. Immediately season the pasta with salt and more red pepper flakes, to taste, if desired. Let simmer for a few minutes to combine flavors.


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Webinar: SMART Goals – A How-To, Hands-On Working Session
December 10 @ 10:00 am - 11:30 am
Webinar Description:
When creating project, team, or organizational goals, we are often told to make them SMART. What does it mean to have goals that are specific, measurable, achievable, relevant and time-based? How do you create SMART goals? How does their creation help you think about your definition of success?
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Jill Hurst-Wahl is a consultant, speaker, writer, and educator, who understands the power of good communications. She is the president of Hurst Associates, Ltd. and professor emerita in Syracuse Unversity's iSchool. In her various roles, including in team-based environments, Jill has been responsible for goal setting and goal attainment. She understands that goals must be well defined, so that you know when you have reached them.
Live captioning will be provided by Rev.com. This webinar will be recorded and a recording will be shared with all registrants afterward.
**All participants will have the option to request a certificate of attendance for 1.5 contact hours.**
All CLRC events are open to CLRC members and members of the Empire State Library Network.


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The signing of Martin represents a first step for MSN into the realm of original entertainment on the Internet, it was reported.


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Bertolt Brecht, J.B Priestley, Somerset Maugham, Christopher Fry, Peter Usinov, Tom Stoppard, Bernard Kops, Henry Livings, Alan Bennett et al are other essential playwrights of twentieth century English literature. He wrote a number of the greatest lyric poems within the English language like The Solitary Reaper, I Wandered Lonely as a Cloud, Ode on the Itimations of Immorality, Decision and Independence etc.


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The oldest documented form of feng shui, Form School is how feng shui was practiced thousands of years ago before the invention of the magnetic compass. These ancient people studied the land, qi flow and the principles of yin and yang. From this, they learnt how best to site their homes, ensuring plentiful harvests and healthy livestock, thereby ensuring their own prosperity.
Today using Form School means analysing natural features such as trees, hills, mountains, rivers and lakes. In the urban environment, this also includes other buildings, walls and fences. Form School is still relevant today, and particularly important in Flying Star Feng Shui.
Sincerity, Faith , Commitment & Self Discipline
Form School Feng-Shui is combined course with Compass School Feng-Shui duration is 2 Days.
For More Details Please Do Enquiry Below
Enquiry Now


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Monika. Age:27. I want to find a strong man who can deliver pleasure. I like to try something new.. Waiting for a real man.
Pool Party HD Porn Tube. XXX Videos & Movies - muchmorethansanta.com
Milady Goddess of Gratification. Age:24. A charming girl with a gentle smile and a gentle look will invite you to visit or come to You.


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Hallmark Bunnies By The Bay that plays music.
Rolling Penny stand 12" tall. Cute dress with cherries. Her apron reads "When friends meet hearts melt". She has a cute hat with cherries that matches her dress. She has a rolling pin in her hand. She is free standing. She has a domed body with a flat bottom that keeps it upright. Under her dress in the back is a wind-up key to play music. She plays Strauss Waltz.


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Really appreciate Prof. Wright give us such rich content and sophisticated course. I really enjoy and love it. I am looking forward to seeing more high-level courses from Prof. Wright if there is any.
Wonderful course where Craig Wright delves into all eras of classical music and takes you along for the wonderful ride! Craig Wright is one of the best instructors I have come across! Enjoy the ride!
교육 기관: Aleksei A•
Excellent course for beginner in classical music.
교육 기관: Silvina•
Me encantó y me fue muy útil!!, muchas gracias!!
교육 기관: Mucahit C•
This was the best online course I have ever had.
교육 기관: Gavin C•
If I could I would double my rating to 10 stars!
교육 기관: Richard H•
Thank you for a different and refreshing course.
교육 기관: Ulrich B•
I am now motivated to hear more classical music
Best course ever! I'm already sad it just over.
교육 기관: Neel M•
One of the best courses I've taken on Coursera!
교육 기관: Justin W•
Top-Notch! An excellent musician and educator.
교육 기관: matias j•
Excellent content. Very clear and interesting.
교육 기관: Miguel S C•
Amazing information, loving everything so far!
교육 기관: Adela L•
great analysis on Antonio Vivaldi lol, love it
교육 기관: Debjyoti•
Nice way they teach.
Everyone should try it
교육 기관: Alisha P•
Great course on understanding classical music.
교육 기관: Andrés W•
Excellent course! Very very very recommended!
교육 기관: Winnie L•
Absolutely brilliant course. Truly enjoyable.
교육 기관: Jessica N L•
Great Professor, Great content, Great format.
교육 기관: André S•
Brilliant professor and engaging discussions!
교육 기관: 许慧都•
I think it is very interesting and helpfully.
교육 기관: Lendis S•
The best music course in Coursera! Thank you!
교육 기관: Julian A R P•
Muy entretenido e instructivo, aprendí mucho
교육 기관: Alvaro d l R•
Thanks for making this course ! amazing !!!!
교육 기관: Christoph A•
A wonderful course with a wonderful teacher!
교육 기관: Daniel A A V•
Me gustaría que tuviera subtítulos. Gracias.
Exceptionally good! Thanks a lot Dr. Wright!


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Ruf der Wälder
The call of the woods
Directed by: Franz Antel, Austria, 1965Austria, 1965
Cast and Credits
|Neue Delta Film, Wien
|Neue Delta Film, Wien
|Franz Antel
|Kurt Nachmann
|Director of Photography
|Siegfried Hold
|Johannes Fehring
|Hans-Jürgen Bäumler [Bernd Hellwig]
|Judith Dornys [Tina]
|Ellen Farner [Petra]
|Mario Girotti [Marcello Scalzi]
|Paul Hörbiger [Gustl Wegrainer]
|Eva Kinsky
|Johanna Matz [Angelika Hirt]
|Franz Muxeneder [Pepi Nindl]
|Rolf Olsen [Kubesch]
|Erich Padalewski [Felix]
|Rudolf Prack [Prachner]
|Raoul Retzer [Zingerl]
|Gerhard Riedmann [Mathias]
|Gerhard Riedmann [Hofraetin]
Technical specifications
Technical Details: ,Length: 85 minutes
Sound System: not indicated
Referenzen zum Film in anderen Datenbanken:
DisclaimerThe information above does not purport to be exhaustive, but give the level of information to our database at the time of last update. All figures are best knowledge and belief researched to, legal claims arising from incorrect or missing information are expressly rejected.
Due to the current law in some countries can be held responsible person who addresses refers to having a criminal content spread may or criminal content and pages further refer, unless he closes clear from such liability. Our links below are researched to the best of my knowledge and belief, but we can not accept in any way for the content of these web pages and links from us any liability. We provide this explanation by analogy from all countries and all languages of. Quotations, if not otherwise marked, in the usual right to quote with identification of the sources added.
The copyright lies with the authors of these quotes - Ruf der Wälder (1965) - KinoTV Movie Database (M)


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Life is unpredictable. Astrology may help to bring some insight.
Visit www.thinkastro.com/2020.html
for more insight in new year..
Corona is new buzzword. It is going to redefine the way business will happen going forward. No risk expert had predicted it. We are stuck with an enemy we hardly know. Offices have lockdown. After lockdown is over ,we will be in new era of work life. Those who were busy in firefighting are sitting at home. Oil was gold few days back. Everything has changed. We have new battle to fight.
Productivity has less link with time and more with consciousness. Attention has big thing to do. Unfocussed efforts are good in transactions. But most good work needs attention. That's why low pay jobs or transactional jobs are so robotics. They are tiring too, physically.
All emotions are playing in extreme. We are loving too much, hating too much. Feeling exausted and tired. IN cave era, we were more happy. We have less choices. We were more satisfied. Now in era of over-trigger or over-race. Over trigger means more productivity. More race to fill time ahead. More goals and more expectations to get more from people and things.
People are looking for constant state of happiness. It is theoretically not possible. Happiness is most misunderstood concept. Some think it is peace + growth, peace+ joy, or peace + pleasure. There may be many versions. All want it consistent and growing. It is not possible.


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Kang Soo-jin-I is starring in the new tvN drama "Ex-Girlfriends' Club".
She's starring in it with Park Si-yeon and Hwang Jung-eum as well as Song Ji-hyo.
"Ex-Girlfriends' Club" is produced by Kwon Seok-jang from "Pasta" and "Miss Korea" and is about the process of web-toon artist Bang Myeong-soo (Byun Yo-han) and his four ex-girlfriends creating a web-toon into a movie.
Kang Soo-jin-I takes on the role of Song Ji-hyo's film company colleague Park Eun-hye. She is a multi-type employee who is very much needed in the company. She brings energy to the hostile atmosphere of the drama which revolves around a man and his four ex-girlfriends.
Kang Soo-jin-I debuted with the JTBC "Greatest Marriage" and continued to star in "Kill Me, Heal Me" and now "The Ex-Girlfriends' Club".
Meanwhile, tvN "The Ex-Girlfriends' Club" will be broadcasted in May after "Super Daddy Yeol".
Source : www.xportsnews.com/?a...Copy & paste guideline for this article
"Rookie Kang Soo-jin-I to star in "Ex-Girlfriends' Club""
by HanCinema is licensed under a Creative Commons Attribution-Share Alike 3.0 Unported License.
Based on a work from this source
You're reading the news with potential spoilers, make them spoiler free, dismiss
On Joo-wan and Jo Bo-ah 'a thing'
2015/03/25 (Source)
Actor On Joo-wan and actress Jo Bo-ah are in a relationship. According to Sports Donga, "On Joo-w,...More
Lee Min-ho and Bae Suzy's relationship brought up again
2015/03/25 (Source)
The scandal between Bae Suzy and Lee Min-ho was mentioned once again on the SBS TV show "TV News A,...More
"Angry Mom" comes in second
2015/03/25 (Source)
"Angry Mom" came in second. According to Nielsen Korea, the new MBC drama "Angry Mom" recorded 9.1%,...More
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text:
- Orders of Knighthood-> (41)
- Decorations-> (31)
- |_ Royal Red Cross (2)
- |_ Imperial Service Order
- |_ Imperial Service Medal-> (22)
- |_ Efficiency Decoration (6)
- |_ Army Emergency Reserve (1)
- Campaign Medals-> (95)
- Long Service-> (59)
- Coronation & Jubilee-> (15)
- Miscellaneous Medals (6)
- Miniature Medals (17)
- All Products ...
The award of decorations for distinguished military service is an ancient institution.
Decorations may be divided into those awarded for individual acts of heroism and those conferred in recognition of distinguished military, political or social service.
The value of a decoration, where its provenance can be unquestionably established, depends largely on the decoration itself, whether awarded to an officer or an enlisted man, the individual circumstances of the award, the campaign or action concerned, the regiment, unit or ship involved, and the often very personal details of the act or acts of bravery.
The addition of bars to gallantry decorations greatly enhances the scarcity and value of such medals.
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text:
Sale price USD $0.40 Regular price USD $8.00
size please choose size
color please choose color
Packing Content:
1x Front Tempered Glass Screen Protector
1x Cleaning Kit
Thickness: 0.3mm
Edge Radian: 2.5D
Hardness: 9H
Transparence: 99%
Feature:Anti-scratch, Fingerprint-resistant, HD, Ultra-thin, Waterproof
The premium tempered glass screen protector is used for HTC series, it has the following features:
1.Ultra-thin glass(T¡Ö0.2mm) can be treated by toughening under high temperature of 420.
2.Fully transparent: chemically treated transparent tempered glass.
3.Full bonding, automatic adsorption can be repeated bonded.
4.Surface hardness: 9H,3 times harder than PET screen protector. the screen will not get scratched even using hard object such as knives and keys.
5.Delicate touch:On the back side of glass coated with a strong silicone layer to make installation easily and attached screen tightly so as to not affect sensitivity of touch screen.
6.Surface is anti-oil processing (Oleophobic coating), so fingerprints and oil is not easy to stay surface and it is easy to clean.
7.Explosion-proof, shatter-resistant glass breaks into small pieces ,more secure than other glass products,and the glass screen protector will not broken into small piece with sharp edge.It still keeps a whole piece of screen protector to protect your phone screen against scratched.
8.Ultra clear edging craft and Whole transaprency:Realistic picture and more than 99% transparency Much higher transmittance than PET screen protector.
9.Fingerprint-resistant: It makes your mobile phone screen looks clean.
Sale price USD $0.40 Regular price USD $8.00
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text:
A reader writes:
I'm sitting in a coffee shop and I watched the video of the girl being surprised by her father, and I'm literally crying. A barrista comes up and asks me what's wrong, and I show her the video, and she's crying. A couple of other people gather, and they're crying. The whole damned coffee shop is crying.
It did the same thing to me. The love in that moment expressed in the child's face is simply unforgettable.
We want to hear what you think about this article. Submit a letter to the editor or write to firstname.lastname@example.com.
2006-2011 archives for The Daily Dish, featuring Andrew Sullivan


text:
25 Nov 2018 08:26
Is operating a blog being something that you are seeing and hearing about at all times however, not confident what it indicates? If you find oneself curious about the subject, but unsure in regards to what operating a blog is,and what it needs to provide then prepare to achieve the uncertainty cleared up. This article has a lot of recommendations inside of to inform you what operating a blog is about.
Since blogs and forums are created on the more private level, you need to avoid creating in professional hues. This will make it easier for the viewer to connect with you on a private level. This will keep your followers finding their way back afterwards to learn a lot of the blogs you create.
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You can apply for this job via the online application tool. To apply, prepare your CV, a short motivation letter and proof of academic credentials. Selected candidates will be invited for a job interview.For more information please contact Prof. dr. Tom Van Caneghem, mail: firstname.lastname@example.com or Prof. dr. Ines Simac, mail: email@example.com.
You can apply for this job no later than February 14, 2020 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at firstname.lastname@example.com.
The research group Accounting (KU Leuven, Faculty of Economics and Business, campus Brussels) is looking for a doctoral researcher to conduct research in the area of 'auditing' with preferred starting date October 1st 2020 (or earlier). This vacancy will remain open until filled.
Topic: Essays in Auditing
This project aims at conducting novel and high-quality research to address economic questions in the field of (external) auditing. Auditing is a monitoring mechanism that aims to safeguard the credibility and quality of financial reporting. High-quality audits are important as they support public trust and confidence in financial reporting, which contributes to financial system stability. In our research group, we typically conduct empirical (archival) studies using large public and proprietary financial and/or other databases. We refer to the following link for further details regarding research activities within our research group: https://feb.kuleuven.be/research/accounting-finance-insurance/Accounting.
In this project we will investigate a number of research questions that relate (but are not limited) to: auditor regulation; audit market competition; the quality of external audit assurance; and external auditing in industries characterized by systemic risk. The specific focus of the project will be determined in consultation with the candidate, based on prior experiences or interests.
Besides conducting academic research, a small proportion of your time will be devoted to teaching-assistance and the supervision of a limited number of master theses.
Prof. Dr. Tom Van Caneghem
Prof. Dr. Ines Simac
Your job will consist of the following main activities:
We offer employment as a full-time doctoral researcher for a maximum period of 4 years (pending positive yearly evaluations).


text:
This site is entirely user-supported. See how you can help.
We don't have any photos of this building yet. Why don't you be the first to send us one?
Latitude: 51.3311 / 51°19'52"N
Longitude: 1.3152 / 1°18'54"E
OS Eastings: 631041
OS Northings: 164332
OS Grid: TR310643
Mapcode National: GBR X0G.HBF
Mapcode Global: VHLGC.RS4Y
Plus Code: 9F3388J8+C3
Entry Name: The Bell Inn
Listing Date: 11 October 1963
Last Amended: 7 October 1986
Grade: II
Source: Historic England
Source ID: 1223820
English Heritage Legacy ID: 419695
Location: Minster, Thanet, Kent, CT12
County: Kent
District: Thanet
Civil Parish: Minster
Built-Up Area: Minster (Thanet)
Traditional County: Kent
Lieutenancy Area (Ceremonial County): Kent
West Side)
5/30 The Bell Inn (formerly
11-10-63 listed as Nos. 1 and 2)
Public House. C16, reclad mid C19 and extended. Timber framed and
rendered on ground floor with ornamental tile hanging on first floor
with plain tiled roof. Extended with yellow stock brick and slate
roof. Timber framed range: 2 storeys with moulded eaves cornice to
hipped roof with 4 hipped dormers and stacks to end left and rear left.
Four glazing bar sashes on first floor and 2 to right and 2 tripartite
glazing bar sashes to left on ground floor. Central half-glazed door.
Extension to left (the Tea Gardens): 2 storeys curved in double curve
around road corner. Brick corbelled eaves cornice to irregularly hipped
roof, with stack to left and 2 lead capped ventilators. One glazing bar
sash on each floor, and blank window space to left on first floor, all
with painted heads. Half-glazed door to right. Interior: altered, but
frame still partly visible.
Listing NGR: TR3103264332
This text is from the original listing, and may not necessarily reflect the current setting of the building.
Other nearby listed buildings


text:
All Timber
The following is a comprehensive list of Timber milling, recycling, manufacturing and processing establishments available mainly to Industry, however at times direct to the general Public too. The Category of Timber incorporates the specialised establishments involved with manufacturing, importing, exporting &/or selling wholesale timber products, including all variations of manufactured wooden laminates, milled or recycled timbers, timber products for building, furnishing, fitting out, etc., as well as timber or wood products such as charcoal (e.g. often used in the food industry for flavour, by artists for drawing, etc.) , wood chips (e.g. often used for garden mulch, etc.), wood shavings, (e.g. often used to flavour foods, paper manufacturing etc.), etc.
Timber is a Sub Category of Wholesale | Raw Materials.


text:
Digital Transformation
Dec 11, 2019
DigitalOps: The link between digital and operations to deliver your brand promise
"The only sustainable advantage you can have over others is agility, that's it. Because nothing else is sustainable, everything else you create, somebody else will replicate." — Jeff Bezos, founder of Amazon
Winning in business is increasingly about speed. How quickly an enterprise can deliver a great customer experience (CX) at scale separates the winners from the losers. You can find DigitalOps at the intersection of digital and operations and has CX as its guiding principle. Developing a DigitalOps competency is how companies will deliver on their brand promise and differentiate themselves in the market.
What is DigitalOps
Let's begin with definitions from leading industry analysts. Gartner defines DigitalOps as: "the 'process' center of your digital transformation, providing the orchestration of systems and other resources. It incorporates mechanisms for sensing and responding, while potentially supporting dynamic learning and optimization."
At a high level, Gartner views DigitalOps as the beginning of a business discipline for increasing organizational agility. It encompasses a holistic set of methods and enabling technologies associated with how the firm delivers value via a digital platform in real time.
DigitalOps give businesses the agility to survive in an ever-changing world. CX has replaced cost reduction as the primary driver for process improvement, but it's digital business transformation that's the top priority – and for good reason. McKinsey research shows that "Organizations that report successful digital transformations are more likely to embed advanced digital technologies in their operations. And are 1.8x more likely to modify standard operating procedures to do so."
CX as the new corporate battleground
To thrive in the experience economy, DigitalOps is essential. It's people, process, and technology intelligently orchestrated to deliver outstanding CX at scale. DigitalOps can provide a sustainable basis for continuous optimization and transformation.
For example, let's look at Netflix. Originally a mail-order DVD provider, CEO Reed Hastings has digitally transformed his business to build a streaming service with over 158M subscribers. With the vision of becoming the best global entertainment distribution service, Netflix has DigitalOps as a core competency.
Companies striving to win in today's marketplace recognize that they must reimagine entire customer journeys. These are the end-to-end processes that customers interact with to get the product or service they need, when and how they need it. And in order to scale, business operations are becoming increasingly digital and real-time in nature.
Therefore, agility is key. Harvard Business Review describes how agile processes almost always result in higher team productivity and morale, faster time to market, better quality, and lower risk than traditional approaches. And according to analyst firm HfS Research, "Creating an engaging customer experience is more readily achieved by embedding increasingly sophisticated digital and cognitive technologies into the very fiber of an organization's processes, from its front office right through to its back office."
Successful companies are exceptionally agile, leveraging the power of real-time data to predict customers' needs faster than competitors can. DigitalOps enables them to not only spot predictions but, more importantly, to act on them.
Developing a DigitalOps mindset
To develop a DigitalOps roadmap, you must make a mindset shift to view your operational investments not as stand-alone projects, but as an integrated set of synergies. Below are some guidelines to help you on your journey:
- Get support from your executive team. Sell the benefits of using process-centric models and technologies to drive digital transformation to your executive team. With so many examples of how DigitalOps and a focus on CX are fueling leading businesses, it shouldn't take too much convincing.
- Develop your long-term plan. Prioritize quick wins but also look beyond potential short-term ROI. Leverage new process discovery and mining tools to gain deeper insight into where to make additional investments, and remember to maintain your employee and end customer experience as your guiding principle.
- Use the right tools for the right job. Robotic process automation (RPA) has its place, but an intelligent business process management suite (iBPMS) is better suited for more complex processes. Advanced analytics and artificial intelligence tools are also increasingly required for the necessary prescriptive intelligence and ability to learn.
- Try something new. When you have a solid DigitalOps foundation in place, embrace the opportunity to experiment with how to shorten and evolve business product offerings by reconsidering your approach to business processes. It's this agility that will keep you ahead of your competition.
- Leverage an industry expert. To develop your DigitalOps, you need a trusted advisor with a combination of deep industry knowledge, process domain expertise, and experience with innovative digital solutions. Industry analysts can help you develop a shortlist of potential partners.
Building your DigitalOps strategy requires a commitment to ongoing transformation. Don't be fooled by technology hype or seduced by something shiny and new. On the contrary, you need sustained focus and prudent investments to make your operations more agile. Your company will then be ready to take on anything that the future throws your way.


text:
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If you are interested in learning more about our dynamic team and how you could assist us to deliver our services, particularly our industry-leading advice related to privacy and data protection, please contact our Practice Manager,
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We are especially interested in hearing from senior lawyers (with at least eight years' PQE) who have gained a broad range of specialist data protection law experience, although you may have a broader commercial/IT background.
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