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Watch Brooklyn Nine-Nine Online: Season 6 Episode 3Paul Dailly at .
Did Jake and Gina find something to like about their old friends?
On Brooklyn Nine-Nine Season 6 Episode 3, the pair attended their 20th high-school reunion and had to face some people they wanted to leave in the past.
Meanwhile, Charles helped Rosa with her love life, but it quickly turned into a disaster when a potential date got the wrong end of the stick.
How did it all play out?
Use the video above to watch Brooklyn Nine-Nine online right here via TV Fanatic.
Paul Dailly is the Associate Editor for TV Fanatic. Follow him on Twitter.


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Information about the City's leadership team and corporate structure.
City Manager and CAO
Paul A. Mitcham, P.Eng., MBA
Phone: 905-896-5550
Email: email@example.com
Learn more about the City Manager
Our mandate is to liaise with Council and work with them to set the City's policy direction; provide advice and support to internal business partners that enables them to advance the City's strategic vision, protects their business operations and manages risk. We also work closely with our business community to support, enhance and expand Mississauga's business sector.
- Economic Development
- Internal Audit
- Legal Services
Commissioner Corporate Services and Chief Financial Officer
Gary Kent, CPA, CGA, ICD.D
Phone: 905-615-3200 Ext. 5265
Email: firstname.lastname@example.com
Corporate Services Mandate
Our mandate is to support our business partners in the delivery of programs and services to our community. We do this by providing innovative, timely and professional advice and service in the areas of information technology, communications, facilities management, procurement, revenue services, financial planning and management, human resources and legislative services.
- Strategic Communications
- Facilities and Property Management
- Finance
- Human Resources
- Information Technology
- Legislative Services, Office of the City Clerk
- Revenue, Materiel Management
Commissioner Community Services
Shari Lichterman, CPA
Phone: 905-615-3200 Ext. 3071
Email: email@example.com
Community Services Mandate
Our mandate is to provide programs, services and opportunities that deliver on our citizen's leisure and recreational needs; support their educational and informational pursuits; enrich their lives with unique cultural experiences and resources; and allow them to enjoy Mississauga's diverse green spaces. We are also responsible for emergency planning initiatives that support city-wide preparedness and protecting, educating and responding to our citizen's fire and emergency needs.
- Culture
- Fire and Emergency Services
- Library
- Parks, Forestry and Environment
- Recreation
Commissioner Transportation and Works
Geoff Wright, P.Eng., MBA
Phone: 905-615-3200 Ext. 4940
Email: email@example.com
Transportation and Works Mandate
Our mandate is to ensure that the department continues to focus on four main areas; Urban Mobility, Asset Management, Service Delivery, and People and Culture. This will ensure that we progress the City's vision for a multi-modal transportation system that enhances our existing transit service operations and provides convenient choices for our citizens and those travelling through our city. We ensure the City's roadways, bridges, sidewalks and related assets are well planned, constructed and maintained. We are also responsible for an effective storm water management system that safeguards public and private infrastructure and property; and enhances water quality. We provide information, support and guidance to internal business partners, citizens and land owners regarding development applications and seasonal programs; we enforce compliance with municipal by-laws and maintain order, safety and community standards in our community.
- Enforcement
- Infrastructure Planning and Engineering
- Hurontario LRT Project Office
- MiWay
- Traffic Management and Municipal Parking
- Works Operations and Maintenance
Commissioner Planning and Building
Andrew Whittemore, M.U.R.P.
Phone: 905-615-3200 Ext. 5561
Email: firstname.lastname@example.com
Planning and Building Mandate
Our mandate is to provide information, advice and support to Council, internal business partners, citizens, developers, consultants and land owners regarding the land development approval process – from the planning of raw land through the processing of development applications and building permit issuance to final building inspections. We are also responsible for providing data and advice on matters affecting the planning and development of the City.
- Building
- City Planning Strategies
- Development and Design

subset: commoncrawl


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Digital Journal Sunday March 5, 2017
Four regions in Africa were singled out last month by the U.N. General-Secretary in a $4.4 billion appeal to avert catastrophic starvation and death. The four regions also share a common thread tying them to their circumstances - violent conflict.
Populations in Somalia, along with northeast Nigeria, South Sudan, and Yemen, are all facing food insecurity to one degree or another due to an ongoing drought, failed crops and internal violence. These problems have forced people to flee their villages and sometimes even their countries in order to find food, clean drinking water, and personal safety.
Somalia - 110 die of hunger in 48 hours
At a meeting Saturday morning of the Somalia National Drought Committee, Prime Minister Hassan Ali Khaire announced the first drought-related death toll in the nation since the Somalia government declared a national disaster on Tuesday. The UN estimates that 6.2 million people are at risk of starvation out of a population of 10.8 million.
"I was informed today that more than 110 people have died due to the current drought only for the past 48 hours in parts of Somalia, particularly Bay and Bakol regions," Khaire said at a press conference Saturday in Mogadishu, reports Voice of America.
Since 2012, when an internationally supported government was established, Somalia has been inching toward stability, however, there is still violence from the Al-Qaeda-aligned Al-Shabab insurgents to deal with. While many people have fled to Mogadishu seeking food, water, and shelter, people in Al-Shabab-held villages are without help or international aid assistance.Lake Chad Basin hard hit by Boko Haram and starvation
The Lake Chad Basin includes northeast Nigeria, Cameroon, Chad, and Niger, and is home to 7.1 million people and an additional 2.76 million internally displaced people. Continued violence by Boko Haram as well as counterinsurgency operations by the Nigerian government has been the reason for additional population movements that have put added stress on host communities forced to feed the newcomers.
The director of the Emergency and Rehabilitation Division, FAO, Dominique Burgeon told the Vanguard that with almost 90 percent of the population in the basin being farmers, the continued violence has kept them from planting crops or harvesting anything they were able to plant.
He said: "In the worst-affected areas, famine continues to loom — and millions will remain trapped in cycles of severe hunger if we don't enable farmers to start cropping now." But the UN also cautions that if the cycle of violence isn't stopped, economic stability will never be realized and over 515,000 will be at risk of starvation or even death.
South Sudan's civil war fuels famine and refugee crisis
Acting U.S. State Department spokesman Mark Toner said in a statement on February 20 that the South Sudan crisis is man-made, calling the famine "the direct consequence of a conflict prolonged by South Sudanese leaders who are unwilling to put aside political ambitions for the good of their people."
The population in South Sudan are fleeing rebel and government troops alike, and over 740,000 have already fled to neighboring Uganda where they live in refugee camps that are already strained. The UN says many have already died from hunger and another 100,000 people are on the brink of starvation. More than 4.9 million people need food assistance immediately.
Again, like in the Lake Chad Basin region, farmers have been unable to plant crops because of the civil war, while many families have dropped everything to flee to safety, leaving behind what little they had in the first place. To add to the crisis, the government has refused to let aid agencies inside the borders.
South Sudan is also on the verge of an all-out genocide, yet many observers are saying the world is just sitting on the sidelines, watching to see what will happen. Others suggest that there are limits to what other countries are allowed to do even with perceived government atrocities being committed. It is a strange situation and the only people who will suffer are the citizens.
Yemen and the world are at war as the population suffers
Yemen is a country in chaos. The UN's Under-Secretary-General for Humanitarian Affairs and Emergency Relief Coordinator, Stephen O'Brien wrapped up a five-day mission to Yemen the other day, saying life-saving humanitarian programs need to be implemented immediately in the war-torn country.
"We need more than funds. We also need all parties to the conflict to immediately facilitate timely, full and unimpeded humanitarian access," Mr. O'Brien said. "More suffering and the specter of famine is encroaching on the very people the parties claim to be fighting for – the time is now to prove their seriousness. This includes access to cities, ports and the reopening of airports and airspace."
The humanitarian crisis escalated in 2015, and now, almost 19 million people, two-thirds of the population are facing starvation. O'Brian said that over 7 million people don't even know where they will find their next meal. And it is not just food that is needed, but medical aid. Over 500,000 children are now at risk of starvation and a child is dying every 10 minutes. "However bleak the outlook, there is still time to alleviate suffering and avert a famine in Yemen," Mr. O'Brien said at the conclusion of his third mission to Yemen as the UN relief chief.v


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What Is Fha Mip
MIP is an insurance premium paid to the FHA for its guarantee of the mortgage to your lender. It is this FHA guarantee of your mortgage that motivated the lender to extend the loan to you. These insurance premiums fund the loan losses incurred by the FHA. The Mortgage Insurance Premium is paid by the borrower in two parts.
Fha Mi Rates 2019 · FHA loan limits are the maximum allowed loan amount for Federal Housing Administration loans. FHA Loans are federally insured mortgages designed for middle- and working-class Americans. Because the loans are insured, lenders provide excellent rates for first time homeowners and those with poor or no credit history.
Mortgage insurance is a policy that protects lenders against losses that result from defaults on home mortgages. fha requirements include mortgage insurance.
*No Revision to the time period for Assessing Annual MIP For loans with FHA case numbers assigned on or after June 3, 2013, FHA will collect the annual MIP, which is the time on which you will pay for FHA Mortgage Insurance Premiums on your FHA loan.
30 Yr Fixed Mortgage Rates Fha 30 Yr Fixed Mortgage Rates Fha | Mortgagelendersinpennsylvania – mortgage rates 30 Year Fixed – Ojaijan – View and compare urrent (updated today) 30 year fixed mortgage interest rates, home loan rates and other bank interest rates. Fixed and ARM, FHA, and VA rates. Chicago, IL: $200,000, 20% down, 30 year fixed mortgage, All Points, Credit score 740+.
What I see: Locally, well-qualified borrowers can get the following fixed-rate mortgages at zero points: A 15-year FHA (up to.
How FHA mortgage insurance premiums work, and how to cancel your monthly MIP. With the right steps, eliminate FHA MIP in 30 days or fewer.
FHA MIP Chart shows the mortgage insurance fee required for FHA loans. How you can drop/avoid PMI and check FHA mortgage insurance premiums.
If an FHA loan is ideal for you, the mortgage insurance premium is something you're likely going to have to live with for the life of the loan. The FHA requires mortgage insurance for all loans.
FHA mortgage insurance refunds are available for fha loans opened less than 3 years ago. Assumed FHA mortgages are not eligible for an MIP refund. You must refinance into another FHA loan to receive an MIP refund. FHA MIP refunds are available only if you have not entered into foreclosure or been seriously delinquent on your payments.
Fha Loan Rule Federal Housing Administration/U.S. Department of Housing and. – The Federal Housing Administration (FHA) is the largest mortgage insurer in the world with an active insurance portfolio of over $1.3 trillion. Each year, FHA helps more than a million homebuyers achieve the dream of sustainable, affordable homeownership of single family homes, while our.
· Did you know that you may be entitled to an FHA mortgage insurance refund if you refinance your home within three years of opening your FHA loan?. When you get an FHA loan, you pay a mortgage insurance premium at the time of closing.
Early last year, the Obama Administration shook up the housing world when it ordered the Federal Housing Administration to cut its annual mortgage insurance premiums by 50 basis points, from 1.35% to.
· FHA loans with terms of 15 years or less qualify for reduced MIP, as low as 0.45% annually. In addition, there is an upfront mortgage insurance premium (UFMIP) required for FHA.


text: Club news November 2020 October 2020 September 2020 August 2020 July 2020 June 2020 May 2020 April 2020 March 2020 February 2020 January 2020 December 2019 November 2019 October 2019 September 2019 August 2019 July 2019 June 2019 May 2019 April 2019 March 2019 February 2019 January 2019 December 2018 November 2018 October 2018 September 2018 August 2018 July 2018 June 2018 May 2018 April 2018 March 2018 February 2018 January 2018 December 2017 November 2017 October 2017 September 2017 August 2017 July 2017 June 2017 May 2017 April 2017 March 2017 February 2017 January 2017 December 2016 November 2016 October 2016 September 2016 August 2016 July 2016 June 2016 May 2016 April 2016 March 2016 February 2016 January 2016 December 2015 November 2015 October 2015 September 2015 August 2015 Westward League XC Exeter Posted by: Chris Turner 8th December 2016 Round three of the Westward League Cross Country took place on Sunday, on a cold but very dry day. The venue for this event was in the playing fields and woods adjoining the Exeter Arena, and included within it were the Devon Championships. Injury and illness made for a few last minute changes to our men's team but all the runners put in great efforts and ran well. Andy Vallance was the first of the men and the only male to have entered the Championships, coming home in 31.25 giving him 14th place in the Championships and 2nd in his age category. Matt Pitson was next with another good run in 32.00 and Rob Kelly in 33.08. Hugh Robinson ran nearly the whole race with Chris Turner on his heels, but he managed to hold him off right to the finish with them clocking 33.56 and 33.59 respectively. Stuart May was next in 36.20 and George Haskell came home in 37.39. The ladies race saw a doubling of ORC entries from the previous meeting in the senior ladies race, with six runners taking part, and Eleanor Marvin running in the under 15 age category. Again Molly Marvin was the first ORC home with a great run to finish in in 20.55, giving her a qualifying sixth place in her age category for the Devon Championships. Sarah Marvin followed her home in 21.24, coming 5th in her age group with Juliet Paterson next in 22.42. Anne Binns was next, pleased with her time of 23.22 in her first race back from injury, followed by Jane Jackson in 24.59 and Mags Jarvis in 27.07. Eleanor Marvin ran very well over the 3.9k course, against a fast field of very competitive under 15 entrants, to come home in 19th place in a time of 16.25. December's Run in the Park took place earlier that morning and we were pleased to see the cold weather has not scared the runners away – Santa even made a debut! The fourth round of the Westward League is on 15th January at Westward Ho! ORC members can enter this race for free, you just need to wear a club vest or t-shirt. Please get in touch with Andy Vallance if you would like to take part. If you are in need of some club kit (or just want some more) please email ORC, with your name, kit request and size. Jane will bring your order along to club, where you can try it on and pay. Many thanks to Jane for the run report Post navigation ← Bicton Blister & Downton Half Marathon First Chance 10k, January Jaunt, SW XC Champs & The Dopey Challenge →


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Florida Antiaging Doctors and Antiaging Clinics. Florida antiaging doctors and anti aging clinics is a list of anti aging and holistic healthcare sources for Indiana.
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A family practitioner is a doctor who specializes in caring for people of all ages, at all stages of life. Rather than focusing on the treatment of one disease or patient population, family practitioners are often the doctors that people see for their everyday ailments, like cold and flu or respiratory infections, and health screenings.
Get information, directions, products, services, phone numbers, and reviews on Advanced Weight Loss Clinic in Chipley, FL. … Advanced Weight Loss Clinics is a medical weight loss program that has helped thousands of … Marianna, FL.
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spiritual counseling body soul bliss (850) 238-0566 – Jamie Brown – 5702 Arnold Road – Panama City, FL 32404 profile: professional spiritual Advisor for famous psychic services on t.v., now offering private consultations, yoga instruction, holistic wellness and spiritual counseling.
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After rumours swirled last week of a potential Nike Air Force 1 collaboration with Kendrick Lamar, it looks like another long-awaited model has surfaced – with Kung Fu Kenny lacing a special edition of the React Element 55.
Composed in 'Pure Platinum', 'Clear Wolf Grey', and black, the sneaker is expected to land on November 5.
As always, for all things K.Dot, keep it locked to Sneaker Freaker.
View this post on Instagram
*RELEASE DATE LEAK ALERT*: The long awaited @Nike x @kendricklamar React Elements will finally be dropping worldwide on November 5th. The pair will retail for $150. Will you be looking to cop? Let us know! Please RT & Follow for more info on future drops. #NoMoreSecrets 🏴


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COAL: The Trump Administration's efforts to save struggling coal plants hasn't slowed utilities' plans to shut them down. (Bloomberg)
TRANSPORTATION: Groups backed by the Koch brothers are working to defeat public transit initiatives around the country. (New York Times)
***SPONSORED LINK: The 2018 Renewable Energy Conference: A Leadership Forum on Energy Policy, in Poughkeepsie, New York, June 26-27, features topics including emerging technologies, energy policy, and profitability. Don't miss the premier renewable energy conference on the East Coast! Register today!***
CLIMATE: Emails show some White House staff pushed back on EPA administrator Scott Pruitt's plan for a "red team/blue team" climate science debate, with one advisor calling it "out of control." (E&E News)
UTILITIES: Florida's NextEra Energy has quietly grown into a "green Goliath" by relentlessly capitalizing on renewable energy subsidies. (Wall Street Journal)
EFFICIENCY: The body that oversees Maine's energy efficiency programs says it's too risky to give grants to businesses that grow cannabis, despite it being one of the state's most energy intensive industries. (Portland Press Herald)
COAL ASH: The U.S. EPA agrees to shift oversight of toxic coal ash in Oklahoma to state agencies, a first-of-its-kind move that the coal industry had sought and environmentalists opposed. (Associated Press)
OIL & GAS: A Chinese energy firm cited a pending trade war as the reason it tabled a potential $84 billion Appalachian shale investment. (Pittsburgh Post-Gazette)
RENEWABLE ENERGY: Supporters of a Nevada clean energy initiative say they have enough signatures to put the measure on the November ballot. (Reno Gazette Journal)
• Nebraska landowners deed 1.6-acres to the Ponca Indian Tribe in hopes of preventing the Keystone XL pipeline from passing through the property. (Omaha World-Herald)
• The U.S. Commerce Department has received hundreds of requests from pipeline companies seeking relief from steel tariffs. (Reuters)
• Some environmental groups are skeptical of Ameren Missouri's request for incentives for EV charging stations due to the utility's relatively large coal portfolio. (Energy News Network)
• A plan by Massachusetts-based utility National Grid to reduce greenhouse gas emissions calls for a rollout of nearly 10 million electric vehicles by 2030. (NGT News)
• Just a week after announcing it was laying off 9 percent of its workforce, Tesla opens a new Model 3 production line at its California factory. (Los Angeles Times)
• The CEO of Proterra discusses the outlook for electric buses. (E&E News)
TRANSMISSION: Outdoor enthusiasts in Maine are torn over whether to support a transmission line that would deliver Canadian hydropower to Massachusetts. (Maine Public)
EMISSIONS: A new report highlights the economic challenge of transitioning from natural gas to electric heat. (Greentech Media)
***SPONSORED LINK: Join the Association of Energy Engineers (AEE) and Host, Puget Sound Energy, for the West Coast Energy Management conference and expo June 20-21 in Seattle. Use code EMC18CO at checkout for $200 reduced conference registration.***
• Politifact examines a statement from the EPA claiming greenhouse gas emissions have declined under President Trump.
• An activist group tries to persuade Republican lawmakers on a carbon tax. (E&E News)
COMMENTARY: Integrating California's grid with neighboring states benefits everyone, says the director of an energy efficiency and technology group. (San Francisco Chronicle)


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Columns Padded with Blanks after Online Migration from MySQL to Oracle
(Doc ID 1548909.1)
Last updated on AUGUST 04, 2018
Applies to:Oracle SQL Developer - Version 3.2 to 4.2.0 [Release 3 to 4]
Information in this document applies to any platform.
After an online migration from MySQL to Oracle columns are padded with blanks to the length of the column.
For example the returned value is-
"OUR World************************* "
when the expected return value is-
"OUR World"
=> ************************ are trailing spaces added to the length of the column.
To view full details, sign in with your My Oracle Support account.
Don't have a My Oracle Support account? Click to get started!


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01-13-2011, 18:10
Anyone else use one of these? We got about 6" of snow yesterday and I decided to take the kids for a ride. We have had it for three years now and the kids just love it. They have even been known to fall asleep in it!
View Full Version : Kindershuttle ski pulk


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Dr. Angela Davis will be honored during a virtual ceremony on Friday, June 19 or Juneteenth, by the Birmingham, Alabama, Civil Rights Institute where the author and activist will receive the Fred L. Shuttlesworth Award.
"The Fred L. Shuttlesworth Human Rights Award is the highest award given by the Birmingham Civil Rights Institute that honors outstanding individuals for their significant contributions to civil rights and human rights.
Davis, who was born in Birmingham, will be interviewed by Professor D. Wendy Greene, the first African American woman to become a tenured law professor at Drexel University in Philadelphia.
In January 2019, the Civil Rights Institute announced that it would honor Davis with the award but withdrew it because of objections by board members and others that she was in support of Palestinians. After a backlash, the board decided to reinstate the award. Click here for further information about the ceremony: The event is free


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Responding to a Crisis
How Accountants Help Lead the Charge During Difficult TimesRead More
Expose your students to the internship interview process.Read More
Use mind mapping to explore how accounting relates to other business departments.Read More
Conflict is an unavoidable side-effect of human interaction. Show your students how uncomfortable situations can serve as opportunities to innovate and to strengthen relationships.Read More
Deciding where to go to college is a complex decision. This worksheet helps students consider what's most important to them so they can choose the right college or university.Read More
It's easy to incorporate this fun, interactive accounting-principle-based game into the classroom with the included Educators' Guide.Read More


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*thelovemaze.com Singles Dating Party Online* Offline Party
Due to the coronavirus, please call to ensure this event is still happening before you leave home.
|View Website
Not a video chat. It's virtual games. Join thelovemaze.com Speed Dating Party Online, meet offline and experience the "scientific love crystal ball" together.
A profile and RSVP in LoveMaze is required to attend: https://thelovemaze.com/events . A smart phone with data connection is required onsite.
thelovemaze.com Speed Dating Party Online: Like nothing you've ever experienced, it's LoveMaze's monumental contribution to human love empowered by modern technology. Stable matching — reveals the best prospect you can secure from the group. Gamification — tests compatibilities based on your natural and genuine psychological tendencies and preferences. Virtual—enables you to stay true to self and be free from the sway of physical attraction and the distraction of real-world noises. Science — better than a crystal ball, it combines Mathematics, Psychology, Behavior, Social, Relationship, Compatibility; love is a complex subject. Fast, easy, powerful, effective, and fun — 30 minutes go a long way in the virtual world!
The Speed Dating Parties Online is for you to — Get a true sense of each other and the probability of success before you fall in love. Grasp what matters in the long run and whom your true counterpart should be for a happy uplifting life.
Join the party, cut through noises, get down to the fundamentals, see through a reality lens, identify your one-and-only for life.
Venue: Brookfield Place
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What do you think?
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thelovemaze.com Singles Meet & Match in Ice Cream at Rockefeller Center
Don't let your ice cream melt while you are counting somebody else' sprinkles. True love is like vanilla ice cream. There may come many eclectic flavors, but there shall be only one classic. Th...
thelovemaze.com Singles Walk In The Park, COVID Stress Relief at Washington Square Park
De-stressing is important to get us back to normal. While we practice social distancing, we might still need a dose of mental support from basic human interaction conducted safely. A physical walk in ...
thelovemaze.com Singles Meet & Match in Ice Cream at Newport Centre
Don't let your ice cream melt while you are counting somebody else' sprinkles. True love is like vanilla ice cream. There may come many eclectic flavors, but there shall be only one classic. Thi...


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Here is the daily GK update of 18th July 2020 covering the following news headlines: Gabon, Uttarakhand, CBSE, IBM, HCL Tech, Global Manufacturing Risk Index.
Daily GK updates are incorporated with the important news that made the current affairs headlines for banking or other competitive exams. Daily GK Update is the complete bag of the important news that held all day long. One should have complete knowledge about the banking terms, current affairs news, etc. So, here is the GK update of 18th July 2020 to help you prepare the Current affairs part. After reading this section, you can successfully attempt Current Affairs Quiz.
International News
1. Ossouka Raponda appointed as 1st woman PM of Gabon
- Rose Christiane Ossouka Raponda has been appointed as the first woman prime minister of Gabon.
- She is the 12th PM of the country and succeeds Julien Nkoghe Bekale.
- Prior to holding this position, Ossouka Raponda served as Defence Minister since February 2019.
- Her appointment is the fourth cabinet reshuffle by the President of Gabon, Ali Bongo Ondimba since January 2019.
Important takeaways for all competitive exams:
- Gabon Capital: Libreville; Currency of Gabon: Central African CFA franc.
State News
2. Uttarakhand govt to generate electricity from waste
- The Uttarakhand government has decided to convert waste generated in the state to electricity under an initiative titled 'Waste to Energy'.
- According to Uttarakhand Environment Protection and Pollution Control Board (UEPPCB), this waste can generate up to 5 megawatts of electricity and curb pollution.
- The scheme also aims to solve the problem of unavailability of landfills to dispose of the solid waste across the hill state with has 10 out if 13 districts as hill areas.
Important takeaways for all competitive exams:
- Chief Minister of Uttarakhand: Trivendra Singh Rawat; Governor: Baby Rani Maurya.
Agreement & MoUs
3. CBSE ties up with IBM to integrate AI curriculum
- The Central Board of Secondary Education (CBSE) has integrated a new Artificial Intelligence (AI) course for class XI and XII in the current academic year (2020-2021).
- The curriculum was developed in collaboration with IBM (International Business Machines Corporation).
- The IBM AI curriculum is a part of CBSE's Social Empowerment through Work Education and Action (SEWA) program.
- The IBM AI curriculum is structured around a course framework for students consisting of base strands of knowledge (basics, history, applications), skills (design thinking, computational thinking, data fluency, critical thinking) and values (ethical decision making, bias) in AI.
Important takeaways for all competitive exams:
- CBSE Chairman: Manoj Ahuja.
- CBSE Head Office: Delhi.
- IBM Executive Chairman: Virginia M. Rometty.
- IBM Chief Executive Officer: Arvind Krishna.
- IBM Headquarters: New York, United States of America.
Appointments News
4. Roshni Nadar Malhotra becomes new chairman of HCL Tech
- India's wealthiest woman, Roshni Nadar Malhotra becomes the new chairman of Noida-based IT company, HCL Technologies.
- The appointment of non-executive director Roshni Nadar Malhotra to the new role takes effect immediately. She will replace her father, Shiv Nadar. Shiv Nadar will continue to be HCL Tech's managing director, with the designation as the chief strategy officer.
Awards & Rewards
5. CPJ International Press Freedom Award 2020 announced
- The Committee to Protect Journalists (CPJ) has announced the recipients of the International Press Freedom Awards 2020 include Shahidul Alam from Bangladesh, Mohammad Mosaed from Iran, Dapo Olorunyomi from Nigeria and Svetlana Prokopyeva from Russia.
- All four journalists have faced arrests or criminal prosecution in reprisal for their reporting.
- In addition to them, lawyer Amal Clooney will be honoured with the Gwen Ifill Press Freedom Award 2020.
Important takeaways for all competitive exams:
- CPJ Headquarters: New York, US.
- CPJ Executive Director: Joel Simon.
Ranks and Reports
6. India ranks 3rd in Global Manufacturing Risk Index 2020
- India is the third top-most country in the Global Manufacturing Risk Index 2020.
- The annual Global Manufacturing Risk Index (MRI) report was released by the US-based property consultant Cushman & Wakefield, to rank the most suitable locations for global manufacturing among 48 countries in Europe, Americas, and the Asia-Pacific.
- Each of the countries has been assessed in four key areas: Bouncebackability, Conditions, Costs and Risks.
- China and the United States retain the top two positions respectively in MRI 2020, while India has moved one place higher from the previous edition of the report, to rank third in MRI 2020.
Sports News
7. Real Madrid clinch record 34th La Liga title
- Spanish professional football club, Real Madrid has been crowned La Liga Champions for the 34th time after defeating Villarreal 2–1 at Estadio Alfredo Di Stefano in Madrid, with one match remaining.
- Karim Benzema was the leading scorer for a 2-1 victory against Villarreal.
Important Days
8. Nelson Mandela International Day celebrated on 18 July
- The United Nations observes 18 July every year as Nelson Mandela International Day.
- The day acknowledges Nelson Mandela's contribution to the struggle for democracy internationally and the promotion of a culture of peace throughout the world.
- Nelson Mandela Day is an occasion for all to take action and inspire change.
Important takeaways for all competitive exams:
- Headquarters of United Nations: New York, USA; Founded: 24 October 1945.
- Mr Antonio Guterres is the Secretary-General of the United Nations.
9. Arjuna awardee para-athlete Ramesh Tikaram passes away
- Arjuna awardee, para-athlete and para-badminton player, Ramesh Tikaram passed away due to COVID-19.
- He won many medals in shotput and Javelin throw including an international meet in Nottingham in 1995.
- He was awarded the Arjuna Award for his excellence in para-athletics and badminton in 2002.
- He became the founder secretary of the Badminton Sports Association of India for the Challenged, now known as the Para-Badminton Association of India in 2000.
Miscellaneous News
10. Priyanka Chopra Jonas appointed as ambassador for TIFF 2020
- Bollywood actor, Priyanka Chopra Jonas has been chosen as the ambassador of the Toronto International Film Festival (TIFF) 2020.
- Priyanka has joined the list of 50 celebrated filmmakers and actors who are invited as the ambassadors of the TIFF.
- Bollywood filmmaker Anurag Kashyap has also been chosen for TIFF 2020.
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A SHOW of strength wowed youngsters at a local art gallery - as they marvelled at a model skyscraper made of paper.
The gravity-defying sculpture is the work of artist Damian Cruikshank, who uses sheets of paper to create three dimensional objects.
The tower is one of a collection of pieces on exhibition at Salford Museum and Art Gallery until January 18.
As well as creating giant structures, Damian uses his design skills to transform paper into delicate and dainty models.
Damian is on a two-year Arts Council-supported scheme based at the gallery and is working towards a major exhibition at the start of 2005.
The present show gives visitors a preview of the work he has been producing for the past year.
Exhibitions officer Meg Ashworth said "Damian's work is fantastic and we are delighted to have had the chance to work with him over the pat year.
"It is amazing to think that these complex structures all started out as a flat piece of paper."
During the show Damien will be providing extra activities and visitors can meet him. Information from the gallery on 0161 736 2649. And on Sunday January 11 there is an artists' workshop for 10-16 year olds. Advance booking necessary.


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Map Marker Key
Renewable NW is not an owner or operator of any projects listed on this page. Please do not contact us with with project-specific questions.
Golden Hills Wind Project
- Wind
- Approved
West of Wasco in Sherman County, Oregon.
Avangrid's 400MW Golden Hills Wind Project is to consist of 125 turbines located immediately west of Wasco in Sherman County, OR.
Location of Avangrid's 400MW Golden Hills Wind Project, as determined from the Oregon EFSC filing.
Golden Hills Wind was originally approved for 267 turbines and 400MW by BP Alternative Energy. The original certificate approved for a completion date of 12/31/14. The certificate was amened twice, after which ownership was shifted to Orion Renewable Energy Group, and the construction start and completion dates were extended out to 6/18/16 and 6/18/19 respectively. Approval of Amendment #2 was given on 1/30/15. Orion Renewable Energy Group then sold the project to Avangrid. (Sale closed Sept 11, 2017.)
On 12/17/15, Orion filed Request for Amendment #3 to reduce the number of turbines from 267 turbines to 125 turbines, remove 2,800 acres from the site boundary, and extend the construction start and completion dates to 6/18/18 and 6/18/21 respoectively. The Council approved the Final Order on Amendment No. 3 in February 2017.
Note: This project was originally planned to be developed in two 200MW phases. Combined into a single project for the RNW project list later.


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Gap has abandoned plans to break itself up and announced another senior executive departure, in another sign of how retailers are struggling with their strategic responses to upheaval in the industry.
The New York-listed company, valued at almost $7bn, had laid down plans almost a year ago to separate its Old Navy division from the rest of the group, which includes Banana Republic as well as its namesake brand.
However, the retailer said on Thursday that the "cost and complexity" of the proposed separation meant it was no longer worth pursuing. It also said weaker operating results spurred the change of course.
The rethink comes just over two months after Art Peck, chief executive, who had championed the split, stepped down. The group has yet to appoint a permanent replacement. On Thursday, the company also said that Neil Fiske, head of the Gap brand, was leaving.
The announcements, along with the disclosure that earnings this year would be better than previously expected, sent the company's shares up as much as 7 per cent in after-hours trading.
The idea behind the split was to unlock value at Old Navy, whose value-oriented offering has allowed it to cope better than its stablemates with the pressures in retail. Mr Peck had argued that Old Navy had a different business model to — and its customers had little in common with — the group's more expensive brands.
Investors initially welcomed the plan, pushing the stock up 16 per cent in a single day after it was announced.
However, Old Navy's results have since deteriorated along with those of the wider group. Figures released soon after Mr Peck's announced departure in November showed the division's third-quarter like-for-like sales fell 4 per cent compared with the same period a year ago.
Wall Street's enthusiasm about the plan faded, with a succession of analysts questioning the value it would create for shareholders. Since the day-one jump when the company set out the plan, Gap shares had fallen 37 per cent.
Robert Fisher, Gap chairman, a member of the company's founding family who has also been serving as interim chief executive, said on Thursday that the original objectives of the plan "remain relevant". The preparation work had "shone a bright light on operational inefficiencies" at the group, he said.
Directors, he added, were focused on appointing new leadership "with the appropriate experience necessary to lead a portfolio of retail brands and to support our transformation efforts".
Gap said it now expected its full-year earnings ending in February, adjusted for exceptional items, to be "moderately above" its guidance of between $1.70 and $1.75 a share.
The upgrade on Thursday, which followed a reduction in earnings forecasts in November, was thanks to less aggressive promotions over the holiday period than the company had expected, particularly at Old Navy.


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I shout it from the rooftops every single time we share an Autumn inspired weddings – my most favourite season of all is also my favourite to marry in!
As the days get longer and the sun begins to shine (for some parts of the country!) we're saying farewell to Autumn, Winter and the fun of marrying in the cooler season for the year – but not before we send them on their way with a little lovin'! From the colours to the snuggling, I love it all.
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A: John Widdicomb Co. was in business in Grand Rapids, Mich., from 1897 until 2002, when the company closed and its name was sold to L. & J.G. Stickley, Inc., of Manlius, N.Y. Stickley now sells a "John Widdicomb Collection" of traditional pieces. John Widdicomb Co. was known for its high-end designs, which might include your table. Pieces were marked in various ways through the years, but the simple mark "John Widdicomb" was used from the mid-1950s until the mid-1970s. If your table is in good shape, it could sell for $500 or more.
Q: I have a pair of matching vases that I bought in an antiques shop in England in 1956. They are 8 inches tall and have gold lettering on the bottom. Some of the letters are worn off, but it includes "J. Kent, Ye Olde Fo ... Ware, Fenton, England." Can you tell me who made these vases and how old they are?
A: Your vases were made by James Kent, who worked at the Old Foley Pottery in Fenton, England. The pottery was established at Longton, England, in 1897 by James Aloysius Kent (1864-1953) and five of his workmen. The words "Old Foley Pottery" were used after 1955. The company was in business until about 1989, but the name "James Kent" is now being used by another company in Fenton. Your pair of vases could sell for $250 to $300.
Q: We have a quilt that has been handed down in our family. It's made of 36 small flannel flags of countries around the world surrounding a larger 48-star American flag. I think the small flags, each about 5 by 8 inches, were some kind of product premium. Can you tell me more?
A: Little national flags made of flannel were tobacco inserts first used in 1912. It was in July of that year that the American flag started to be made with 48 stars — and it stayed that way until Alaska was admitted to the Union in 1959. Collectors often refer to the flannel tobacco premiums as "blankets." The flags were either wrapped around the tobacco package or inserted in a little envelope inside the package. They came in several sizes and were intended to be used for sewing into bedspreads and pillowcases. So it's not surprising that one of your relatives used them to make a quilt. Collectors of old tobacco inserts want unsewn single flags. But some collectors like quilts made from the flags. We have seen quilts like yours sell for as little as $10 and as much as $650. Price depends on condition, size and where the quilt is offered for sale.
Q: I buy junk jewelry from thrift stores and usually take pieces apart to make my own designs. I don't want to take something apart that's valuable, though. So how do I know if a piece is valuable?
A: What you find in a thrift store may indeed be junk. But it also could be vintage costume jewelry. First get a magnifying glass and check out the backs and clasps of any jewelry you find. Any piece with a mark should not be taken apart, at least not until you check who made it. Once you can make out the mark, check the Internet or books on costume jewelry to learn who used the mark. The Kovels have written two special reports on identifying good costume jewelry. They are available via the Store link at Kovels.com. Costume jewelry is very popular today, so you want to take care of any good pieces you find. Many marked pieces can sell for hundreds of dollars each.
Tip: When regluing loose rungs or parts of chairs, remove old glue with vinegar. Drip it into any holes with a small oil can.
Airplane whistle, makes a sirenlike whirl, propeller twirls, red and yellow plastic, 1950s, 4 x 3 1/2 inches, $30.
Pinocchio lunch pail, round, tin, removable lid, carrying handle, red, Pinocchio on lid, Geppetto, Jiminy, Figaro all around, Walt Disney Productions, 1940, 6 1/2 x 5 inches, $150.
Ed Sullivan Kodak Film store cabinet, tin, image of Ed smiling, "Hold it! Got Film?," four slots with clear tabs to hold film, Kodak logo on sides, 1960s, 7 1/2 x 12 inches, $195.
Marilyn Monroe movie poster, "The Prince and the Show Girl," with Laurence Olivier, Monroe being hugged by Olivier, 1957, 27 x 41 inches, $335.
Political cartoon necktie, rose-colored, "Vote for Roosevelt, Happy Days Are Here Again," image of Roosevelt on donkey, 1932, 4 x 43 inches, $475.
Toothache Puppy Dog cookie jar, brown dog, white scarf tied around face, one paw up, American Bisque, 1950s, 14 inches, $500.
Superman doll, wood and composition, jointed, movable head and upper body, original cape, Ideal Novelty & Toy Co., 1940, 13 inches, $1,600.
Wedgwood Queensware portrait pitcher, satyr handles, raised grapevine garlands, caricature busts, rows of leaf tips at base, 1830s, 12 1/2 inches, $1,615.
George III butler's tray on stand, mahogany, rectangular paneled top with hinged gallery sides, pierced hand grip, scalloped edges, square legs, 1790s, 38 x 32 inches, $2,070.
Rooster copper weathervane, full body and comb, open beak, large wattle, steel support rod, 1880s, 18 3/4 inches, $3,450.
Something Old: The truth about old-time advertising
Deceptive advertising has been a problem for centuries. The "cures" of Victorian times were promoted with posters, trade cards, almanacs, recipe books, calendars and other testimonials.


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A thesis statement is the single, specific claim that your essay supports. A strong thesis answers the question you want to raise it does so by presenting a topic, the position you wish to defend, and a reasoning blueprint that sketches out your defense of your chosen position. A good thesis is not merely a factual statement, an observation, a personal opinion or preference, or the question.
Writing an essay on only primary text(s) can be challenging enough therefore, a paper that requires secondary sources may seem confusing and can add to the challenge of essay writing. But fear not, because the following tips will hopefully give you some ideas as to how you can incorporate the words of scholarly authors into your research essays.
Think of your thesis as a signpost that lets readers know in what direction the paper is. They present a writers analysis or interpretation of primary source materials. You maintain your integrity as a member of an academic community by.
In the social sciences, a secondary source is usually a scholar book, journal article. Of sources in a literature review are secondary sources that present. In improving your overall research paper because secondary sources.
Try to use quotations from secondary sources sparingly, if at all.
Department of english state university of new york college at geneseo. In your humanities paper, the essays introduction invites your reader into your. Rarely do opening lines like this have anything to do with the thesis of the paper,. Make sure you discuss the primary source, rather than simply focusing on what it.
The sources, develop a thesis, outline your main points, and write the essay. It should present your analysis of the meaning and significance of the source(s).
Alternatively, you might contact the university librarian for history, laurie scrivener,. In your finished paper, however, feature your thesis in the introduction.
You should present tentative conclusions and even a thesis statement. Describe the primary sources that you will use for each part of your work.
Primary sources are the building blocks of historical research and should provide. In short, primary sources should drive the paper, not the other way around. Chicago guides to writing, editing, and publishing (chicago the university of.).
Thesis a strong, specific argumentative claim introduced early in your essay. Evidence primary andor secondary sources that support your argument.
This handout provides suggestions for writing papers or responses that ask you to analyze a text through the lens of a critical or theoretical secondary source. By engaging in this type of analysis, you are entering an academic conversation and inserting your own ideas.
A live news-feed (or the transcript of) is a primary source recording events as they unfold. Core texts - academic texts related to the topic being studied - are an. Credibility and authenticity of internet documents is often difficult to establish. Primary sources provide raw information and first-hand evidence. Examples include journal articles, reviews, and academic books. Professional editors proofread and edit your paper by focusing on. Dissertation editing services essay editing services paper editing services thesis editing. Book title write here, right now an interactive introduction to academic writing and research. Create and host a writing e-textbook for first year university students that. Chapter 10 joining the conversation primary sources, secondary.
Boehm (1976) argues that these large costs stem from introducing testing too late in. A thesis (dissertation) is an extensive research paper that is written as partial. For example there is essay on climate change , then please tell me how i develop a thesis statement, and how we write thesis statement, is it is written in the start of essay or in the end of introduction, some people said that thesis satement should be written in start other say that this written in end of introductory paragraph. Readers of academic essays are like jury members before they have read too far.
In a meaningful way, and the final product must be thesis driven. Introduce quotations by putting the name of the writer you drew the material from into your. Readers of academic essays are like jury members before they have read too far, they want to know what the essay.
The need to use secondary sources in your essays is one of the most obvious ways in which degree-level study differs from that at lower academic levels. You can introduce material from a secondary text in order to support a particular.
You to state your thesis in the rest of the opening paragraph. Writing about culture, primary sources may include works of art or literature, as well as. Scholarly books come from university presses and from a hand- ful of commercial. Key points or passages as a means to introduce the authors ideas, but. In the course of this assignment, you will write a thesis-driven essay that articulates reasons. Evidence for an academic argument can be based on primary source material or data. Journals on the history of the us and canada from prehistory to the present. Turabian, a manual for writers of term papers, theses, and dissertations (link is external).


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Advances in molecular diagnostics technologies have sparked innovation, expanded research capabilities, and enhanced clinical diagnostics. Cambridge Healthtech Institute's Fifth Annual PCR and NGS-Based Diagnostics puts an emphasis
on the technologies that drive personalized medicine, from PCR and NGS to microarrays, and showcases how they are being used to alter clinical outcomes. This event will provide a comprehensive look at integrating molecular diagnostics solutions for
biomarker discovery and development, point-of-care, companion diagnostics, and infectious disease. Molecular technologies will be compared and evaluated and case studies on getting regulatory approval will be shared. Overall, this event provides insight
into advanced techniques and tools for effective disease diagnosis.
Monday, February 12
10:30 am Conference Program Registration Open
11:50 Chairperson's Opening Remarks
Apostolia-Maria Tsimberidou, M.D., Ph.D., Professor, Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center
12:00 pm Optimization of Precision Medicine in the Era of Immunotherapy
The availability of novel immunotherapeutic agents and targeted therapy holds the promise of expediting the availability of precision medicine in the treatment of cancer. Development of clinically meaningful biomarkers and optimization of clinical trials
will improve the clinical outcomes of patients with advanced cancer. Objectives: 1) optimization of use of targeted therapy, 2) immunotherapy as targeted therapy: biomarker development, 3) completed and ongoing clinical trials to expedite the implementation
of precision medicine.
12:30 Different Whole Genome Sequencing Strategies for the Clinical Management of Patients with Oropharyngeal Squamous Cell Carcinoma
David I. Smith, Ph.D., Professor, Department of Laboratory Medicine and Pathology, Chairman of the Technology Assessment Group, Center for Individualized Medicine, Mayo Clinic
1:00 Session Break
Luncheon Presentation I: An Engineered DNA Ligase for Efficient Conversion of Input DNA during NGS Library Preparation
John Nicols President & CEO Codexis, Inc.
Molecular diagnostics NGS assays are critically dependent on efficient conversion of low-concentration DNA samples to sequencing-capable fragments via adapter ligation. An engineered DNA ligase was developed to achieve exceptional conversion of low-concentration
input DNA, with improved reaction kinetics relative to T4 ligase, while maintaining low adapter dimerization activity. The Codexis Performance DNA Ligase is ideally suited for NGS IVD applications, where it will improve assay sensitivity and increase
workflow flexibility and robustness.
1:40 Session Break
2:30 Chairperson's Remarks
2:40 Panel DiscussionModerator: Apostolia-Maria Tsimberidou, M.D., Ph.D., Professor, Investigational Cancer Therapeutics, University of Texas MD Anderson Cancer Center
3:10 Clinical and Informatic Approaches to Genomic Screening of Ostensibly Healthy Individuals
Matthew Lebo, Ph.D., Director, Bioinformatics; Assistant Professor, Pathology, Brigham and Woman's Hospital, Harvard Medical School
This talk will focus on approaches to implement a genomic screening program for unselected cohorts. Specific considerations will be placed on the clinical informatics components required to scale variant annotation, filtration, review, and reporting.
Results from several studies will highlight key considerations and outcomes when utilizing different approaches.
3:40 Challenges of Validating NGS Assays: Using Hearing Loss Gene Panel as an Example
Rong Mao, M.D., FACMG, Medical Director, Molecular Genetics and Genomics, ARUP Laboratories; Assistant Professor, Pathology, University of Utah School of Medicine
With the advent of massively parallel sequencing methodologies, the number of genes implicated in human disease has increased substantially in the last decade. This has led to a surge in the number of clinical laboratory tests offered to detect genetic
causes of inherited disorders. As more clinical laboratories tread the unfamiliar ground of NGS, they are faced with the challenges of establishing validation and quality control processes. Here I am using a hearing loss gene panel as an example
to discuss validating the NGS assay, limitations of the assay, and CAP/FDA guidelines.
4:10Validation of RNA Fusions for an NGS Based Clinical Assay
Helen Fernandes, Ph.D., Co-Director, Genomic Oncology, Columbia UniversityThis presentation will focus on the design, development, and validation of an NGS assay to detect RNA fusions from FFPE tissue. The advantages of using highly multiplexed reference materials to achieve faster development time, lower validation costs, improved performance, and for submission to state regulatory agencies will be discussed.
4:25 Nuclease-Activated Probe (NucAP) Technology for Cancer Detection Shambhavi Shubham, Ph.D., Postdoctoral fellow, Department of Internal Medicine, University of Iowa
4:40 Refreshment Break and Transition to Plenary Session
5:00 Plenary Keynote Session (click here for more details)
7:30 Close of Day
Tuesday, February 13
7:30 am Registration Open and Morning Coffee
8:00 Plenary Keynote Session (click here for more details)
9:00 Refreshment Break in the Exhibit Hall with Poster Viewing
10:05 Chairperson's Remarks
Weian Zhao, Ph.D., Assistant Professor, Department of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Lifesciences Center for Advanced Cardiovascular Technology, Department
of Biomedical Engineering, University of California–Irvine
10:15 One-Step, Rapid Detection of Antibiotic Resistant Bacteria in Blood Stream Infections Using High Volume Droplet Blood PCR
Weian Zhao, Ph.D., Assistant Professor, Department of Pharmaceutical Sciences, Sue and Bill Gross Stem Cell Research Center, Chao Family Comprehensive Cancer Center, Edwards Lifesciences Center for Advanced Cardiovascular Technology, Department
of Biomedical Engineering, University of California, Irvine
Antibiotic resistance represents a major global health threat. Lack of rapid diagnostics in the current paradigm of clinical microbiology, especially for bloodstream infections (BSIs), has resulted in use of inappropriate or unnecessarily
broad-spectrum antibiotics, which are associated with significantly increased morbidity, mortality and healthcare cost as well as having the potential to select for resistant strains. In this presentation, we will discuss a new high
throughput blood droplet PCR technology for rapid bacterial detection directly in blood samples without culture and sample processing.
10:45 Rapid Phenotypic Antibiotic Susceptibility Testing Directly from Clinical Samples Using Single-Molecule Counting
Rustem Ismagilov, Ph.D., Professor, Chemistry & Chemical Engineering, California Institute of Technology
Rapid antibiotic susceptibility testing (AST) is critical for delivering care and enabling antibiotic stewardship. Phenotypic AST is the gold standard, but is unacceptably slow, requiring pre-culture steps. Genotypic AST has not been sufficiently
general to replace the gold standard (especially in Gram-negative organisms). We use SlipChip for digital single-molecule counting of pathogen-specific RNA and DNA to perform phenotypic AST directly from clinical samples in as fast
as 30 minutes.
11:15 Developing Ultrasensitive Molecular Methods for Rapid Bacterial Identification and Antibiotic Resistance Profiling
Shana Kelley, Ph. D., Professor, Department of Pharmaceutical Sciences, University of Toronto
We are developing several different platforms for rapid bacterial analysis and the detection of antibiotic resistance. Devices that enable genetic analysis in heterogeneous samples will be described.
11:45 Enjoy Lunch on Your Own
1:25 Refreshment Break in the Exhibit Hall with Poster Viewing
2:00 Chairperson's Remarks
Elaine Lyon, Ph.D., Medical Director, Molecular Genetics and Genomics, ARUP Laboratories; Professor, Pathology, University of Utah School of Medicine; Past President, Association for Molecular Pathology
2:10 Regulatory Innovation: Keeping Pace with NGS atop the Shifting Sands of Precision Medicine
Peggy Carter, Ph.D., Global Head, Regulatory Affairs, Oncology Precision Medicine, Novartis
Regulatory innovation may no longer be an oxymoron. The "one drug, one test" paradigm in precision medicine is not sustainable and we look to technologies such as NGS and new ways of regulatory thinking to move to the next
level. Recent examples of first-of-their kind approvals in the precision medicine space reveal the beginnings of a much-needed paradigm shift.
2:40 Setting Up a Framework to Facilitate Implementation of Performance and Design Standards for Clinical NGS
Birgit Funke, Ph.D., FACMG, Vice President, Clinical Affairs, Veritas Genetics; Associate Professor, Pathology, Harvard Medical School
Next-generation sequencing (NGS)-based testing has transitioned from a niche technology to widespread adoption in clinical testing. Numerous recommendations and guidelines provide high level education but detailed and practical implementation
support is lacking. This presentation describes an effort led by the College of American Pathologists (CAP) that provides systematic step-by-step education to guide clinical testing laboratories through all steps of the lifecycle
of a clinical NGS test.
3:10 Towards Design Control for LDTs: Establishing Performance Criteria for NIPT
CLIA requires that high complexity laboratories establish and verify performance characteristics before introducing a new testing procedure. Laboratory developed procedures (LDPs) may be validated under CLIA and CAP accreditation standards,
while ISO15189 accreditation and FDA clearance specifies that validation/verification must be performed under design control. This presentation will discuss establishing, validating and verifying performance characteristics under
design control for LDPs, using non-invasive prenatal testing (NIPT) as an example.
3:40 Using Genetics to Select Safer Targets and Drugs
Lucas D. Ward, Ph.D., Senior Scientist, Human Genetics and Functional Genomics, Comparative Biology and Safety Sciences, Amgen
Genetics is increasingly being used in two major ways: to discover new targets through variation in populations (studying diseases), and to stratify drug response clinically (studying patients; pharmacogenetics). Early-stage genetic
validation often focuses more on efficacy than safety. I will discuss how genetics can be used, even pre-clinically, to improve safety: anticipating target-mediated adverse events, which we have demonstrated are statistically linked
to target genetics; and constructing drug selectivity panels.
4:10 Valentine's Day Celebration in the Exhibit Hall with Poster Viewing
5:00 Breakout Discussions in the Exhibit Hall
These interactive discussion groups are open to all attendees, speakers, sponsors, and exhibitors. Participants choose a specific breakout discussion group to join. Each group has a moderator to ensure focused discussions around key
issues within the topic. This format allows participants to meet potential collaborators, share examples from their work, vet ideas with peers, and be part of a group problem-solving endeavor. The discussions provide an informal
exchange of ideas and are not meant to be a corporate or specific product discussion.
Next Generation Sequencing (NGS) in Precision Medicine
Prasun Mishra, PhD, Founder & CEO, Agility Pharmaceuticals
Isothermal Molecular Diagnostics as Alternatives to PCR
Robert Meagher, PhD, Research Scientist, Sandia National Laboratories
6:00 Close of Day
Wednesday, February 14
7:00 am Breakfast Presentation (Sponsorship Opportunity Available)
7:30 Registration Open and Morning Coffee
10:00 Refreshment Break and Poster Competition Winner Announced in the Exhibit Hall
10:50 Chairperson's Remarks
Gregory Storch, M.D., Ruth L. Siteman Professor, Pediatrics, Washington University School of Medicine
11:00 Relative Roles of PCR and NGS for Viral Diagnosis
Several important trends are occurring in diagnostic virology. Amplification-based testing is maturing, with increasing availability of FDA-approved and cleared assays. Some testing is moving towards centralized platforms in core laboratories
while other testing is moving centrifugally to near and at point-of-care locations. NGS offers very exciting potential for nonbiased detection. This talk will describe these trends and their interrelationships.
11:30 MPseq and Its Applications to the Clinical Setting
George Vasmatzis, Ph.D., Co-Director, Biomarker Discovery Program, Center for Individualized Medicine; Consultant, Department of Molecular Medicine; Associate Professor, Molecular Medicine, Mayo Clinic College of Medicine and Science,
Rochester, MN
We have developed MPseq, an accurate and inexpensive whole genome sequencing platform that has been used to detect structural variants. MPseq is a combination of a protocol and algorithms that can replace several cytogenetic tests
and provide comprehensive diagnostic value with high specificity, sensitivity and cost-effectiveness. Most importantly our process can provide a detailed description of all DNA rearrangements at a resolution that can show how individual
genes are disturbed thus providing necessary novel insight for correct clinical interpretation.
12:00 pm Molecular Detection of Emerging Pathogens in Low-Resource Settings
Robert Meagher, Ph.D., Research Scientist, Sandia National Laboratories
Emerging infectious diseases often occur in parts of the world that lack even the most basic infrastructure that underlies modern clinical diagnostics. We summarize developments in molecular assays, sample prep, and detection that
increasingly allow laboratory-quality diagnostic assays to be performed in low-resource settings, including our own work with smartphone-based detection of viral pathogens. We also discuss limitations of these techniques and open
areas of inquiry, including tradeoffs between simplicity and assay performance.
12:30 Session Break
12:40 Enjoy Lunch on Your Own
1:10 Dessert Break in the Exhibit Hall and Last Chance for Poster Viewing
1:50 Chairperson's Remarks
2:00 GV9 – A New, Sensitive and Economic Method for Species-Level 16S Bacterial Characterization
Seth Crosby, M.D., Director, Partnerships & Alliances, Washington University School of Medicine
16S methods currently employed are, generally, limited to analysis of a single hypervariable region which makes taxonomic classification difficult beyond the genus level without a substantial false positive rate. To address this issue,
a novel method, named GV9, has been developed to enhance species level calls and abundance estimates through simultaneous analysis and dynamic selection of multiple hypervariable regions.
2:30 Multiplex Real-Time PCR Assays that Assess the Abundance of Rare Mutations Associated with Cancer
Fred Kramer, Ph.D., Professor, Microbiology, Biochemistry & Molecular Genetics, Public Health Research Institute, Rutgers University
"SuperSelective" PCR primers, due to their unique design, amplify rare mutant DNA fragments in liquid biopsy samples, while ignoring abundant related wild-type fragments. Multiplex PCR assays utilize SuperSelective primers
that contain unique 5'-tag sequences, enabling each different amplicon to be detected with a differently colored molecular beacon probe. As many as 35 different mutations can be assessed simultaneously. These assays are extraordinarily
sensitive, rapid, and inexpensive.
3:30 Session Break
3:40 Chairperson's Remarks
Kai Wang, Ph.D., Principal Scientist, Institute for Systems Biology
3:45 The Prospect of PCR & NGS-Based Molecular Diagnostics
Circulating nucleic acids, especially cell-free DNA, has been the center of most NGS-based molecular diagnostics in recent years. Even though the circulating RNA isn't as well developed as DNA in clinical application yet, it
has tremendous potential. Several factors may impact the analysis of circulating nucleic acids. We will address and discuss some of the possible issues.
4:15 A Non-Invasive Urinary Common Rejection Module (uCRM) QPCR Gene Expression Score for Kidney Transplant Injury
Tara Sigdel, Ph.D., Assistant Professor, Surgery, University of California, San Francisco
Urine offers an attractive source of biomarkers for urological and kidney related diseases. A qPCR assay for a gene panel as a biomarker for kidney transplant rejection and injury has been developed and optimized. The talk will summarize
the strategy for discovery and validation of this assay which is highly relevant in other diseases as well.
4:45 Comparison of Gene Expression Profiles on nanoString vs. Fluidigm qPCR Platforms on Human Renal Allograft Biopsies
Dejan Dobi, M.D., Postdoctoral Scholar, Pathology, University of California, San Francisco
We conducted a performance comparison study between nanoString's nCounter platform (barcoded oligonucleotide-based technology for gene-expression analysis) and standard (Fluidigm) qPCR on matched FFPE and RNA later-preserved
human kidney allograft biopsies. In addition to demonstrating the feasibility of the nanoString platform on FFPE samples, we show various applications to address biologically relevant questions in the renal transplant setting.
5:15 Close of Conference Program
Premier Sponsors


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Viticulture and Wine Science
EIT offers the widest range of viticulture and wine qualifications both on-campus and by distance by highly knowledgeable and experienced lecturers in New Zealand's premium wine growing regions.
Fantastic scholarships and awards are available for our students.
- EIT Year 13 Degree Scholarship
- Bragato Exchange Scholarship
- Hawke's Bay A & P Society Young Vintners Award
- The Constellation Brands Scholarship
- URLAR Wine Scholarship
Discover a great career path. At EIT Hawke's Bay, you'll gain experience in a world-class laboratory complex, fully equipped for all the sciences with an instrument laboratory that houses advanced chemical analytical instruments, a modern teaching and research winery, sensory laboratory, vineyard and glasshouses.
We also have a demonstration vineyard which is sited adjacent to the winery.
Positive industry feedback for EIT's new Cellar Operations programme
From 18 January 2021, EIT's School of Viticulture and Wine Science will offer the new Certificate in Cellar Operations (Level 3). This intensive one-semester programme is fees-free. It is...
EIT's School of Viticulture and Wine Science introduces new fees-free programmes
From beginners looking for a taste of theory and experience for their first vintage, through to those with more experience and expertise wanting to move forward in their career, EIT offers a...
Wine leader chose EIT to upgrade viticulture skills
Wine entrepreneur Erica Crawford has just finished the last exam of her Graduate Diploma in Viticulture at EIT. Erica is the powerhouse behind Loveblock Organic Winery in Marlborough's...
EIT offers a variety of scholarships across various subjects and programme levels. Some scholarships are based on your age, some are specific to the subject you want to study. Not all scholarships are based on your academic ability and anyone wanting to study should investigate what scholarships are available to them.
You can find a list of EIT scholarships here however there are many more scholarships offered nationally. Information about these is on an database called "givME". givME is accessible at EIT or at some public libraries. If you would like to come to EIT to look through the giveME database don't hesitate to contact firstname.lastname@example.com or call in for a chat.