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Our number one priority is to support you and your family. Whether treating a toddler during an emergency, or helping a teen through chemotherapy treatments, we make it our mission to provide the best care—and best experience—for every child.
Specialized care for children and teens
At Children's Healthcare of Atlanta, we are 100 percent committed to kids. We're fully equipped to diagnose, treat and support your child. Our pediatric doctors, specialists and nurses understand that children's medical and emotional needs are different from adults. We use specialized equipment and techniques to provide the care kids need to thrive. Every member of our team has just one focus—help kids and teens get better faster, so they can go home sooner.
No matter what your child's health condition, you can be confident in our experience and skill in treating it. We provide world-class care in more than 60 pediatric specialties.
Read about our awards and recognition
Family-centered care
Family is a big part of your child's well-being. Not only are you a vital member of their healthcare team, you are a source of security and comfort. That is why we work to support your whole family while your child is in our care—and after they go home.
To support your family, we offer:
- Constant access. 24-hour family visitation, including in our intensive care units.
- A place for you. Sleeping rooms, showers, business centers and more for you and your family.
- Extended-stay accommodations. Local accommodations available through the Mason House and Ronald McDonald house.
- Play areas. In-hospital playrooms, so your child can enjoy time with siblings and other children.
- Activities. Events that give your child a chance to have some fun—like swimming, crafts, team sports and programs for teens to socialize.
- Laughter. Humorology Atlanta administers a healthy dose of laughter to patients, families and visitors.
- School support. An accredited hospital-based school program that helps your child complete school assignments and keep up with classes.
- Family support groups. Support groups for families dealing with medical issues including asthma, cancer, blood disorders, heart conditions, diabetes and transplants.
Our Quality Program
Children are our most precious gifts, so we at Children's Healthcare of Atlanta thank you for trusting us with your child's care. We understand how serious this responsibility is, and work every day to give the best care to our patients and their families.


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Study Paves Way for Safer Insect Control10 April 2012
US - A Kansas State University researcher's work has shed new light on which of two genes present in many insect species should be targeted for new insecticides that will be safer for humans and the environment than those currently used.
K-State entomology professor Kun Yan Zhu, along with a team of scientists at K-State, the Mayo Clinic, Oklahoma State University and China Agricultural University, uncovered the functions of two different acetylcholinesterase or AChE genes in the red flour beetle, which is a serious, globally-distributed insect pest of stored grains and grain products found in grain storage facilities, flour mills, grocery stores, warehouses and homes.
The research team's findings were published Feb. 12, 2012 in PLoS ONE (www.plosone.com) and Feb. 27, 2012 in Scientific Reports (http://www.nature.com/srep/index.html), both are online scientific journals.
Acetylcholinesterase (AChE) is a crucial enzyme involved in cholinergic neurotransmission in the nervous system of insects and other animal species. The enzyme breaks down the neurotransmitter acetylcholine at the synaptic cleft (the space between two nerve cells) after acetylcholine has served the function of signal transmission. This keeps the synaptic cleft clear so that next signal transmission can occur.
Commonly used organophosphate insecticides, which are related to nerve agents, are known as anticholinesterases because they are potent inhibitors of AChE. Inhibition of AChE prevents the breakdown of acetylcholine by the enzyme. As such, acetylcholine continues to cause nerve signal transmission, which leads to overstimulation of the nervous system and eventual death of an animal.
For years, AChE was known to be encoded by a single gene in vertebrates and insects. But by 2002, in a breakthrough discovery, a team of researchers led by Mr Zhu found a paralogous or second AChE gene in the greenbug, which is an aphid species that often causes serious damage to sorghum, wheat and other small grains in the world. Since Zhu group's finding of a second AChE gene in the greenbug, scientists have quickly learned that many insect species have two different AChEs.
That earlier work, described in a scientific journal as "a breakthrough in this toxicological riddle…," led to the latest work to determine which of the two genes studied in the red flour beetle is responsible for cholinergic neurotransmission. In turn, that tells the scientists which should be the target for anticholinesterase insecticides and is responsible for insecticide resistance conferred through the target gene mutations.
"After a paralogous AChE was reported in the greenbug in 2002, many scientists identified the paralogous AChE genes in other insect species. It became clear that most insect species possessed two different AChE genes," Mr Zhu said.
"So, the question was what the functions of each gene were. Our study provided the first strong evidence that the paralogous gene is responsible for cholinergic neurotransmission, whereas the first AChE gene which scientists have known about for years and now is called orthologous gene does not appear to play an important role in cholinergic neurotransmission." Orthologous genes are the ones originated from speciation events, whereas paralogous genes are the ones diverged from gene duplication events.
"The red flour beetle was chosen for the more recent research largely because of its robust RNA interference (RNAi) responses," Mr Zhu said. "RNAi is a specific and effective approach for loss of function studies in virtually all species of large complex organisms, including animals, plants and fungi. Once RNAi is triggered, it destroys the messenger RNA, or mRNA, of a particular gene. This prevents the translation of the gene into its product. By silencing each of the two AChE genes in the red flour beetle, we would be able to learn the function of each gene by examining the insect responses to the RNAi."
The scientists found that silencing the paralogous gene in the red flour beetle larvae led to 100 percent mortality and increased larval susceptibility to well-known anticholinesterase insecticides, including carbaryl and malathion. In contrast, silencing the orthologous gene did not lead to insect mortality and increased insecticide susceptibility, but delayed insect development and reduced female egg laying and hatching.
"As consequences," Mr Zhu said, "we observed relatively lower numbers of pupae and adults in the offspring, and determined that such RNAi effects for the orthologous gene were carried through the female rather than the male." Thus, the orthologous gene seems to play non-cholinergic functions but is important for insect growth, female reproduction and embryo development.
That finding reinforces the idea that the AChE encoded by the paralogous gene should be a target of anticholinesterase insecticides, rather than the AChE encoded by the orthologous gene, for the most insect species possessing both AChE genes. However, for a few insect species, such as house fly, which possess only orthologous AChE gene, their control by anticholinesterase insecticides should still relay on the inhibition of AChE encoded by the orthologous gene.
"Based on some unique structures of the enzyme encoded by the paralogous gene, which are not found in mammals and other vertebrates, researchers could potentially develop insect specific and environmentally safe insecticides for control of agricultural insect pests, human and animal disease vectors, and residential insect pests," said Zhu, who has been studying insecticide toxicology since 1987. Indeed, recent studies led by Yuan-Ping Pang at Mayo Clinic have demonstrated that AChE encoded by the paralogous gene is a promising target for developing such insecticides for safer insect pest control.
Other collaborators on the recent project were Yanhui Lu, who was a visiting scholar in Mr Zhu's K-State laboratory from 2008-2010 from China Agricultural University (CAU) in Beijing. She works now at Huazhong Agricultural University in China, Xiwu Gao of CAU, Yoonseong Park, at K-State, Yuan-Ping Pang, Mayo Clinic, and Haobo Jiang, Oklahoma State University. Two of Mr Zhu's former graduate students Xin Zhang and Jianxiu Yao, are now postdoctoral research associates in the Division of Biology and the Department of Plant Pathology, respectively, at K-State.
TheCropSite News Desk

subset: commoncrawl


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Send us your Thanksgiving photos! | Arts & Culture
As the Thanksgiving weekend comes to an end, we ask what the holiday means to you..? Is it family, food, football, Black Friday, volunteering, or maybe just relaxing as you take advantage of your time off?
Please send us a photos of what Thanksgiving means to you along with your name, location and a brief comment about Thanksgiving to email@example.com for our My Town Thanksgiving photo gallery to be published early next week.
Thank you and we hope you've had a wonderful thanksgiving weekend!


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You are currently browsing the category archive for the 'Repentance' category.
1. Get thoroughly dissatisfied with yourself. Complacency is the deadly enemy of spiritual progress. . . . When speaking of earthly goods Paul could say, "I have learned to be content," but when referring to his spiritual life he testified, "I press toward the mark." So stir up the gift of God that is in you.
2. Set your face like a flint toward a sweeping transformation of your life. Timid experimenters are tagged for failure before they start. We must throw our whole soul into our desire for God. . . .
3. Put yourself in the way of the blessing. It is a mistake to look for grace to visit us as a kind of benign magic, or to expect God's help to come as a windfall apart from conditions known and met. There are plainly marked paths which lead straight to the green pastures; let us walk in them. To desire revival, for instance, and at the same time to neglect prayer and devotion is to wish one way and walk another.
4. Do a thorough job of repenting. Do not hurry to get it over with. Hasty repentance means shallow spiritual experience and lack of certainty in the whole life. Let godly sorrow do her healing work. . . . It is our wretched habit of tolerating sin that keeps us in our half-dead condition.


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Advanced Search
MOOCs | Feature
Eschewing the talking-head approach of mainstream MOOCs, NovoEd stakes its claim on MOOCs that emphasize student-centered learning and collaboration.
One of the biggest criticisms of the type of MOOCs produced by edX, Coursera, and Udacity is that they tend to replicate at scale a centuries-old pedagogy: the sage on the stage. It was not always thus with MOOCs. Indeed, the earliest MOOC experiments conducted by George Siemens and Stephen Downes in 2008 emphasized participation and collaboration (such courses are now known as connectivist MOOCs or cMOOCs).
Now a recent entrant to the MOOC scene, NovoEd, is revisiting the original concept by focusing on student-centered learning. Launched in April by Amin Saberi, an associate professor of engineering at Stanford University (CA), the company is the latest in a series of MOOC startups that trace their lineage to the Silicon Valley school.
"The problem right now with most MOOCs out there is that they are focusing on the most boring part of education--the talking head and multiple-choice questions," said Saberi, who is currently on leave from Stanford to focus on his startup. "Education is not the content, it's what you take with you when you forget the content."
It's a message echoed by Anne Trumbore, the company's senior course designer, who laments the continuing acceptance in higher education of the one-dimensional classroom. "Especially in higher education, professors present their knowledge," she said. "But now everything has changed. Instead of teachers demonstrating what they know and students spitting it back, we need teachers not only to show students what they need to know, but also to show them how to use it."
To address this need at scale, the company has created its own MOOC platform to encourage student interaction and participation, using aspects of social media to foster collaboration and specially developed algorithms to organize students into working groups.
Entrepreneurship Roots
Saberi traces the genesis of NovoEd to a colleague's need for a better way to engage students for a course on entrepreneurship. "We created an environment for the students to form teams," he explained. "Each team would work on their own project and their own startup idea. They developed a business model. We taught them how to look at each other's work [online] and how to give feedback to each other. For the top 20 teams, we helped them pitch to venture capitalists in the United States, Germany, Malaysia, India, Chile, and other countries."
Since then, NovoEd has produced nearly 30 courses in partnership with universities, consulting groups, and fellowships. Course topics range from everyday mathematics (Carnegie Foundation) to anatomy (Stanford), but the company has devoted the bulk of its attention to entrepreneurship, including a significant partnership with Babson Global, a subsidiary of Babson College (MA) that aims to extend the school's leadership position in entrepreneurship education worldwide.
Early results from NovoEd's team-centered approach to MOOCs are encouraging. In an August interview with Bloomberg Businessweek, Saberi indicated that some 350,000 students had studied entrepreneurship using the NovoEd platform, with some courses seeing completion rates as high as 47 percent--a huge improvement over mainstream MOOCs, which typically see completion rates of 10 percent or less. In addition, student teams using the NovoEd platform have launched more than 7,000 new businesses.
Key to the high completion rates, believes Trumbore, is the platform's ability to bring together on a global scale people who share a collective interest. "MOOCs will destroy geographical boundaries," she noted. "People who are passionately interested in a topic but spread out across the world will finally be able to collaborate in a real way and form communities around their interests."
Indeed, Trumbore believes the global nature of MOOCs is, in many ways, their greatest advantage over traditional teaching methods. "If you are working on a project about something like decision making or strategy or entrepreneurship, and you're on a team with people all around the world, you're confronting all kinds of different and rich questions--questions of culture," she noted. "What does business look like in France or China versus Silicon Valley? That has the potential to be far more meaningful than sitting in a classroom with 15 other people who look a lot like you. Moving education back into the real world, by way of the virtual world, has a huge potential to engage students in meaningful learning experiences."
Hybrid Possibilities
NovoEd courses (free to $249) are offered as standalones to anyone who wants to take them, but indications are that the company sees greater potential in partnering with schools, institutions, and corporations to create hybrid courses that marry an online component with face-to-face instruction.
"University professors will begin to incorporate MOOCs into their classrooms and their curriculum, but they should have a say in how they are used," said Trumbore. "MOOCs won't displace teaching, but they will enhance teaching. More college students will have an online experience in their on-campus classroom, and that will be a sea change in how we view online education."
For this model to succeed, though, Trumbore believes that the online component must engage students rather than simply lecturing at them. "At NovoEd, we have the collaboration factor," stressed Trumbore. "People can actually work together, and we encourage instructors to think differently about the way they teach--put the student first and assign projects instead of students watching an hour lecture."
This approach will certainly be tested in NovoEd's partnership with Babson. The school plans to develop nearly three dozen entrepreneurship courses on the NovoEd platform that can then be licensed to other schools as part of a blended model, with local instructors receiving training from Babson on handling the face-to-face component.
For Trumbore, this kind of blended approach is further evidence that MOOCs are more likely to supplement traditional education than replace it. "When MOOCs first came out, everyone said they are going to put teachers out of business," she recalled. "That is 180 degrees not the case. Teachers can use this technology thoughtfully to expand the classroom experience and engage students in the classroom."
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A digital scrapbooking template set by Crystal Livesay. These templates are meant to help you record your everyday more quickly and easier! Use these templates over and over by rotating, expanding, flipping, duplicating layers as you see fit! Make these your own to fit your style. These templates are full of paint to add a touch of artistry to your memory keeping!
File contains 4- 12x12 inch layered templates, in .psd and .tiff formats. Templates includes basic drop shadows which can easily be removed or customized. Also included are the individual PNG files for the templates, as well as the .page files for the templates ** PAGE files coming soon **


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- Description
Temperature Celsius Min Max Extruder 235 255 Build Platform 90 110
ASA (Acrylonitirle Styrene Acrylate) is a UV-resistant weatherable polymer. Our ASA has a low-gloss matte finish that makes it a perfect filament for technical prints - especially when you don't want the high-gloss surface finish often associated with many other 3D printing materials such as ABS, PETG, or PLA. ASA's UV-stability makes it an ideal material for outdoor applications that will experience intense exposure to the sun and weather. ASA's exceptional mechanical and thermal properties - coupled with excellent UV-stability - is why this resin is used the Auto, Marine, and RV industries for exterior applications such as mirror housings, cowl covers, radiator grills, and sensor housings.
- Additional Information
Additional Information
Plastic type ASA Extruder:235-255° Heatbed:90-110° Size 1.75mm Color Bright Orange


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Guidance Counseling; Biology. HELP! :-)
Mazurka, in Beyond High School
As of November 1, 2018, the Sonlight Forums are no longer in use. You are currently viewing a static archive of the curriculum forums from our site. There is no ability to start new threads or post in response to existing threads. Please enjoy the rich conversation resources that are archived here.
If you are looking for assistance with curriculum choosing or using, or would like to find a vibrant homeschool community, we do have live resources available for you! Don't hesitate to reach out to our Homeschool Advisor team for help with making education decisions for your family.
Be sure to check out Sonlight Connections, a collaborative community designed to provide support and encouragement on your homeschool journey.
Best wishes on your homeschool journey ...
The team at Sonlight (https://www.sonlight.com/)
Mazurka, in Beyond High School


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When The Social Network was released a few years ago, out of nowhere people were talking about a possible Best Supporting Actor nomination for Justin Timberlake – you remember that? I felt like it was a practical joke. Did we all see the same movie? Every JT scene was cut like a Britney Spears video, quick edits to camouflage his limited range. And still, they kept trying to convince me that he was as skilled an actor as he is a musician. So they continued to offer him movie roles. Lead roles.
He is the lead in Runner, Runner. The movie has dropped down to an 8% rating on Rotten Tomatoes. It was expected to do about $10 million at the box office this weekend. Instead, it underperformed, bringing in just $7.5 million…because, well, audiences don't want to see Justin Timberlake. Perhaps they'd just prefer to hear him?
And finally, FINALLY, some critics are being honest about it. Over at The Atlantic Wire, Richard Lawson calls it the "Problem of Justin Timberlake". Which is what?
"Justin Timberlake has many things going for him! So it would probably be okay if he quietly gave up this whole acting thing. Because, folks, he's just not good at it."
He really, really, really isn't.
But JT had expectations coming into the fall. Runner, Runner and The 20/20 Experience Part 2 were dropping around the same time. If his movie didn't impress, critically or commercially, the music would make up for it, right?
Sales are healthy, sure. But music critics, just like the movie critics, don't seem to be as hard for JT as they used to be. 20/20 Part 2 was not all that well received. According to a Billboard opinion piece, he "should have scrapped" it. Pitchfork calls it "superfluous", and notes that "it actually erases some of the gains made by its predecessor as it plays into the worst trappings of self-indulgence".
Him? Self-indulgent?
Also…immune. Immune to the criticism. People like Justin Timberlake, who live above everything, will call it your problem, and not his. To him, his inspiration is impervious to doubt. Even if it may have resulted from necessity. Because now that we've heard the material, those reports that he rushed out both albums because Live Nation wanted their money's worth seem even more legit, non?
Here's JT on the golf course this weekend while everyone was ignoring his movie. He has a few weeks off before he starts touring again. And during that time he'll be celebrating the one year anniversary of the day he jumped on his wife's head on the cover of PEOPLE Magazine…which he had to share with Britney Spears.


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Explore the wide array of training and defense products and services we provide.
We design, develop, field and maintain fixed, motion-based and mobile simulators. We will build for you an entire simulator, a visual system or custom software - let us propose a solution for you. We also produce high fidelity, simulated, crew-served and shoulder-fired weapons. We produce Host, Aero-Model, Instructor Operator Station and complete simulator software. We create Augmented Reality based systems and have extensive knowledge of the Live/Constructive/Virtual simulation domain. We develop concepts and software for UAV obstacle avoidance and flight extension.
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FRITZ!Box 7430 Service - Knowledge Base
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THE MOST SHREDDABLE Reign EVER. THIS NEW ENDURO CRUSHER DELIVERS FLAT-OUT SPEED AND CONTROL ON RAW, ROWDY TERRAIN.
When it comes to flying down the most extreme enduro terrain, this is the weapon of choice for Giant Factory Off-Road Team riders. Reengineered for 2018, the all-new Reign Advanced features updated geometry with a longer cockpit made with a lightweight, super stiff Advanced-grade composite mainframe and ALUXX SL aluminum rear swingarm. The updated trunnion-mount Maestro suspension system delivers 160mm of smooth, active travel and incorporates a new Advanced Forged Composite upper rocker arm, which is lighter and stronger than the previous aluminum design. And it's all designed around the performance benefits offered by 27.5 wheels. For competitive off-road riders seeking the ultimate advantage on aggressive trails, the new Reign Advanced is the way to roll.
• Okvir od naprednog kompozita sa 160mm Maestro stražnjom suspenzijom
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Sve navedene specifikacije podložne su promjeni bez prethodne najave.


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Actipro Shared Library - Common components for Silverlight Cart Not logged in Log In Register Forgot Password Resend Validation E-mail Products WPF Controls WinRT Controls Silverlight Controls WinForms Controls ASP.NET Controls Code Writer App Icons Download Evaluations Freeware Online Demos Purchase Shopping Cart Price Lists Sales FAQ Support My Account Support Tickets Knowledge Base Consulting Services Community Blog Twitter Page Discussion Forums Polls WPFpedia Company About Us Contact Us Policies Our Customers Testimonials News Room Media Kit Careers Shared Library for Silverlight A set of common controls and useful components for Silverlight applications Online Demo Download Buy Now Learn More Product Overview Controls Transition Effects Latest Release Supported Environments Silverlight 5 or later Expression Blend Other Notes Source Code Available Bundled in Silverlight Studio Resources Silverlight Blog Entries Discussion Forums More Silverlight Controls Additional Benefits Thorough Documentation Help topics cover all controls and product features in great detail. Numerous Samples Many full-source demos and QuickStarts are included. Designer Functionality Configure the product using Visual Studio and Expression Blend designer enhancements. Rock Solid Code All pre-obfuscated code is scanned by the VS Code Analysis tool, and warnings resolved. Transition Effects The Actipro Silverlight Shared Library contains a number of animated transition controls and effects are available for use in your application to give it some extra flair. The transition classes are extensible and provide the foundation for page transitions in our Wizard for Silverlight product. TransitionPresenter The contents may be any object type and can optionally use a DataTemplate or a DataTemplateSelector to build the user interface for the objects. Wizard for Silverlight using the transition presenter with a bar wipe transition to switch between pages Default transition effect directions and durations may be specified. A default mode is used to indicate to a TransitionSelector whether selected transitions that support the mode concept should be In (the default) or Out transitions. Out transitions are generally used when making backwards progress through a sequence of items. A single transition can be used or programmatic logic may be implemented to determine which transitions to use. An included transition selector allows for random selection of a transition from a list of transitions. Built-in Transition Effects There are several built-in transition effects available. Many of the built-in transitions support multiple directions and have an in/out mode concept. This list shows the built-in transitions: Barn door wipe - A wipe transition between two pages that uses two straight bars with a configurable gradient spread. Bar wipe - A wipe transition between two pages that uses a straight bar with a configurable gradient spread. Fade - The old selected page fades into the new one with optional blur effect. Faded zoom - A crossfade transition between two elements that zooms the new content in as well. Slide - A slide transition between two pages that moves one page over the other. Push - A slide transition between two pages that pushes one page out of the way for the other. An example of a fade in transition: Custom Transition Effects Custom transitions can easily be created programmatically or via XAML. Shader Transition Effects In addition to the built-in transition effects, transitions from the Silverlight Pixel Shader Effects Library can also be easily integrated. This list shows the shader transitions: Banded swirl Blinds Blood Circle reveal Circle stretch Circular blur Cloud reveal Crumble Disolve Drop fade Fade Least bright Line reveal Most bright Pixelate (in/out) Radial blur Radial wiggle Random circle reveal Ripple Rotate crumble Saturate Shrink Slide in Swirl Swirl grid Swirl grid (smooth) Water Wave An example of a banded swirl transition: Products WPF Controls WinRT Controls Silverlight Controls WinForms Controls ASP.NET Controls Code Writer App Icons Download Evaluations Freeware Online Demos Purchase Shopping Cart Price Lists Sales FAQ Support My Account Support Tickets Knowledge Base Consulting Services Community Blog Twitter Page Discussion Forums Polls WPFpedia Company About Us Our Customers Testimonials News Room Media Kit Careers Contact Us return false;
Clker.com is owned by Rolera LLC, 2270 Route 30, Oswego, IL 60543 support\at\clker\dot\com


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Park City Education Foundation comes through big
During the 1986 school year, the Park City Education Foundation was established to help raise scholarship money for local seniors graduating from high school. According to Jen Billow, PCEF Communications Manager, a lot has changed for the non-profit organization over the years, and people in the community who are not familiar with the work she and the PCEF are doing for the 4,500 public school students in Park City.
Every year, the PCEF divvies up funds among a variety of grants to the teachers and schools in the Park City School District to fund new programs and teaching techniques proposed by PCSD faculty and staff. In order to allocate money that is raised in the private sector appropriately, the PCEF Teacher Grants' 16-member board Committee combs through a flood of requests ranging from PCHS Robotics Club Engineering after school programs, and money used to send students to national competitions.
This year, nearly $180,000 in school site grants is being awarded to the PCSD by the foundation. Throughout the year, the organization holds a number of events and relies on parents and people of the community to raise money to support the many activities and resources needed by students every year.
"We are passionate about education and really believe strongly that every child deserves the chance to be the best they can be," Billow said. "When we touch an entire school district and help make resources and opportunities available like we do, it is huge and makes such a meaningful difference."
Billow explained that the foundation has three separate grant sections which are used to categorize the different requests that come in throughout the year. The three grant categories are: Teachers, District and the recently awarded School Site grants.
Teacher Grants give educators the opportunity to present the foundation with ideas and materials they feel are needed in the approaching school year. A few of the programs funded from last year included: French Dual Immersion Library (providing Jeremy Ranch Elementary with $2,322 to purchase books), World Geography (Parley's Park Elementary received $1,000 after requested $3,015 for relevant geographic informational text) and FIRST Lego League after School Program (Ecker Middle School received $4,500 to help fund this academic program). The PCEF awarded $48,257 in Teacher Grants for the 2012-2013 school year throughout the district.
District Grants are designed to help school programs, training and technology upgrades in the district as a whole. Some of the programs that received funds from last year include: Latinos in Action ($1,485 was awarded to the Park City High School program to defray start-up costs for a scholarship program), Gifted and Talented Mentoring Program ($10,000 was awarded to the Treasure Mountain Junior High program) and Success Maker/ Compass ($20,000 for the math software needed by Trailside Elementary). In the 2012-2013 school year, the PCEF funded $150,000 in school site grants.
The PCEF holds a number of fundraisers throughout the year to help raise money for their cause. Events include, Author in Residence, Red Apple Gala, Beat the Call Contest and the Phone-A-Thon.
The foundation's approaching spring fundraiser is the 4th annual "Running with Ed". The 38-mile, 10 leg race traversing through Park City has become a major community event with over 2,000 participants raising $130,000 last year, affirmed Billow.
Billow added, last year's "Red Apple Gala" raised $340,000, and is still the leading fundraiser the foundation holds throughout the year.
The foundation raised $800,000 last year through their efforts. Despite the impressive total, Billow argues that to reach the overall goal of $1-million the organization needs more parent involvement.
"Every year we try to raise the bar a little bit higher and in order to do this, we need more parent participation," Billow said. "At this point we have 40-percent of parents donating to the foundation. Six years ago we only had 5 percent, so getting to 90 percent is what we are hoping for. If we are able to make that mark, all of the events we hold during the year will be icing on the cake."
To find out ways to can donate money or to find a list of upcoming charitable events, visit the PCEF website at http://www.pcef4kids.org.
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Everyone remembers that first love whether it's a real vehicle a lady(or man), or an in-game plane.
I remember the first time I flew the I-16(l) in game. I instantly fell in love with that little aircraft. Back then it was a little different. It had a Synchronised 1x12.7mm Gun on it. Its a little slow, but still a beast at its tier. I don't fly it as much as I used to, never quite acquired that 5th star on it.
What was the first vehicle in WoWP that you fell in love with?


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The results of this study suggest a course of action for enhancing professional skepticism, so they are important for audit firms specializing in privately held clients, which is an institutional setting where auditors may find it more difficult to maintain their objectivity. The authors suggest that audit firms can use their internal messaging to help individual auditors decrease the harmful effects of client identification. Specifically, audit firms can encourage auditors to (1) take the perspective of financial statement users (e.g., shareholders), (2) view themselves and clients as members of a group assigned the goal of providing accurate financial statements to shareholders, and/or (3) identify more strongly with the audit firm or the audit profession. Furthermore, the authors suggest that audit firms increase client commitment by encouraging auditors to be more attentive and available to clients (e.g., catching up with clients periodically and spending more time at the client site) and encouraging clients to feel free to reach out to auditors.
Herda, D. N. and J. J. Lavelle. 2015. Client Identification and Client Commitment in a Privately Held Client Setting: Unique Constructs with Opposite Effects on Auditor Objectivity. Accounting Horizons 29 (3): 577-601.
PCAOB Chairman James Doty recently announced plans to convene a task force on audits of fair value measurements, as well as plans to change the auditor's report to provide more useful, relevant, and timely information to users of public company financial statements. The authors hope their commentary is helpful to standard-setters' deliberations, and the authors believe it should be useful to auditing scholars, both as a supplemental reading in auditing courses and a source of ideas to help guide future research designs on auditor and user judgment and decision making for high uncertainty FVA estimates.
Bell, T. B., and J. B. Griffin. 2012. Commentary on Auditing High-Uncertainty Fair Value Estimates. Auditing: A Journal of Practice & Theory 31 (1): 147-155.
The authors contribute to the literature in three ways. First, the results provide support for the agency-based demand for publicly available audit quality signals in a powerful test setting. They find SOX supply-side approach of banning certain NAS may have hurt some registrants if those banned NAS services previously served to increase overall audit quality. Second, the evidence provided herein suggests that registrants learned from the market's negative price protection reaction and, in accordance with agency theory, recalibrated their subsequent year NAS purchases. Finally, the results provide archival, empirical support for the audit committee incentive arguments of Gaynor et al.
Abbott, L. J., S. Parker, and G. F. Peters. 2011. Does Mandated Disclosure Induce a Structural Change in the Determinants of Nonaudit Service Purchases? Auditing: A Journal of Practice & Theory 30 (2): 51-76.
These findings provide important insight into investors' current perceptions of auditor independence, particularly in the absence of relative or comparative information, and suggests that it might be useful for regulators, when contemplating additional disclosure requirements, to allocate some attention to disclosures that have the potential to enhance investor perceptions of auditor independence. The findings of this study contribute to the forum of debate concerning the current state of audit-related disclosures and their value for investors.
Beck, A. K., R. M. Fuller, L. Muriel, and C. D. Reid. 2013. Audit Fees and Investor Perceptions of Audit Characteristics. Behavioral Research in Accounting 25 (2): 71-95.
This study makes several important contributions. This study extends and complements prior research by looking at an additional characteristic of narrative disclosures not accounted for in prior research: language categories. In examining language categories, the authors contribute to the voluntary disclosure literature by: (1) introducing the LCM as a framework for classifying and organizing the language in accounting narratives; (2) validating that the LCM is indeed descriptive of the language included in accounting narratives; and (3) demonstrating that how prior events are construed in a narrative (using different predicate forms) has a predictable effect on investor judgments and decisions. This study is the first to take a meta-semantic approach to the content of accounting narratives and to apply the LCM in an accounting context.
Riley, T. J., Semin, G. R., & Yen, A. C. 2014. Patterns of Language Use in Accounting Narratives and Their Impact on Investment-Related Judgments and Decisions. Behavioral Research In Accounting 26 (1): 59-84.
The authors find that the informative disclosure of non-GAAP earnings information enables investors to better understand firms' future operating performance relative to opaque disclosures. Further, the results suggest that the most pervasive motive behind the disclosure of non-GAAP earnings information is to inform, although an economically significant proportion of firms appear to be opportunistic in that they only disclose non-GAAP earnings information when it increases investors' perceptions of core operating earnings. The study should be useful to investors, financial analysts, regulators, and researchers for assessing the non-GAAP disclosure motives of management and the effect of these motives on market participants.
Curtis, A. B., McVay, S. E., & Whipple, B. C. 2014. The Disclosure of Non-GAAP Earnings Information in the Presence of Transitory Gains. Accounting Review 89 (3): 933-958.
This study claims that, "our understanding of firms' R&D disclosure decisions is limited, and therefore the study's results provides new insights about these decisions by showing that firms adjust their narrative R&D disclosures in response to changes in current earnings performance.
Furthermore, this study's findings, "increase our understanding of firms' narrative disclosure decisions, an important disclosure channel used to convey contextual information about a firm's activities beyond financial statement numbers."
"These findings suggest that narrative disclosures should not be generalized as a whole and emphasize for future research the importance of considering disclosure type in the formation of hypotheses and empirical tests."
Kenneth J. Merkley (2014) Narrative Disclosure and Earnings Performance: Evidence from R&D Disclosures. The Accounting Review: March 2014, Vol. 89, No. 2, pp. 725-757


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Photographer's Note
Back to Pakistan for this shot and probably a few more as I've now got round to sorting out my photos properly. There will be more from Afghanistan later.
I saw this old guy on the streets of Peshawar and was fascinated by his beard. I had to have a photo. But when I looked at him it was clear he wasn't going to let me get close up. The best I could do was to "shoot from the hip" from where I was. The original shows a much wider scene in the street - but with some severe cropping I get a pleasing portrait. I will post the original to a workshop so you can see what I mean. As I cropped a lot, I had to post this image a little smaller than usual to retain sharpness.
KevRyan, robiuk, supereira, crhieatt, nwoehnl, pady, Cliffy, chaity, perryhooter, DLM, journeywood, fadingstar78, rtome, prezntime, stefi, diverjohn, Wandering_Dan, Emile oznaczył to zdjęcie jeko użyteczne
Critiques | Translate
KevRyan (22956) 2005-10-09 6:07
A very nice capture Jonathan - his expression, the lighty and his clothing work together to really say something about him and his character.
best wishes Kev
robiuk (10807) 2005-10-09 6:21
Hi Jonathan,
The contrast between white beard and darkish cloaths & thick black framing makes this face stand out - another point of interest is unusual appearance of the man's mouth being open as if in awe or great surprise...
You did a good job cropping this out from the original scene,
supereira (9576) 2005-10-09 6:51
Great shot.I like the composition and point of view.I like the expression of the man.Good colors,light,textures and sharpness.Very good job!
crhieatt (5347) 2005-10-09 7:06
Hello Jonathan,
I'm not a great lover of portrait photography - probably because I'm so bad at it myself - but this one really grabbed my attention. I can hardly believe that you shot this "from the hip" - perhaps you have discovered the secret of great portraiture - he is not actually looking down the barrel of a camera! Anyway, it's a lovely shot, and the light coming in over his hat really sets it off - not to mention the beard.
entrelec (8328) 2005-10-09 7:13
Very nice, Jonathan,expression, quality,the way you crop and framed.
Colors by nikon, a marvel
sharkattack (268) 2005-10-09 7:22
This is fenemonel portrait......well done
serdarhepgul (1744) 2005-10-09 7:43
MAgnificentt..very impressive and strong.
donluicu (24727) 2005-10-09 7:55
Hello Jonhatan
this is a great portrait..
have you seen Ben Laden over there???
danielswalsh (13597) 2005-10-09 8:42
Great shot Jonathan!
You did a great job cropping to maximize the impact of the image. I really like it!
I have done a wokshop with a couple suggestions which I think you may find of use... let me know?
Keep up the great work!
- Dan
MichaelTrezzi (3374) 2005-10-09 9:06
What a great portrait, Jonathan ! Thanks for sharing the way how you got it, it is really interesting and I am looking forward to seeing the original. Prefect composition. Like an old masters painting. Congratullations. Cheers, Michael
PixelTerror (0) 2005-10-09 9:12
Hi Jonathan,
A lovely portrait where you used the light very well, there are many children portraits on TE, but I find these portraits of old wise people far more impressive, excellent !
Have a nice sunday,
explomars (4302) 2005-10-09 9:29
Merveilleux portrait.Le personnage a beaucoup de charisme sans męme le connaître.Génial.Phil
don_narayan (2014) 2005-10-09 10:13
great portrait. I like the fabric and arm framing, very natural. too bad that his eyes aren't sharper.
jojay (28) 2005-10-09 10:18
very good strong portrait shot well cropped
Cormac (26565) 2005-10-09 11:54
Wow Jonathan! Where did you pull this shot out of? My first impression was that it looks like it could have come right out of National Geographic. Wonderful look to this man, with the beard and the clothing, and from your story you did a brilliant job of capturing it. Superb!
nwoehnl (122) 2005-10-09 13:04
Even shooting "from the hip" (let me know how you do that with the D70 :-), this turned out splendid, Jonathan. I like how he is not frontally facing the lens, and how the details of his face - not least of his fascinating beard - are rendered here. Nice tones and the tight cropping works quite well, too. Good job.
pady (4800) 2005-10-09 13:57
Very nice portrait.
You catched an expression really fascinating.
Thanks for sharing
Cliffy (590) 2005-10-09 14:35
I bet you wanted to do a full session with him because it is one of those faces that cry out to be photographed,we do however have to treat our subjects with respect.I am sure were he to see it that the gentleman would be delighted because the expression and pose are spot on.Despite all the cropping the quality at web resolution is still excellent.
alimo3 (6854) 2005-10-09 15:43
Hi Jonathan,
A great portrait,
i like how you captured this beautiful and noble face.
the light is nice and colors seems very natural.
Nicely done.
jjbach (9326) 2005-10-09 18:57
Hi Jonathan,
The portrait of this old man is excellent. Wonderful colours, lighting and details. The expression of his face is superb! Splendid work!
Regards John
chaity (1539) 2005-10-09 21:03
Hai Jonathan, I like this close crop of the old man. It brings out the feature of the man more as compared to the one in the workshop.
weswang (18223) 2005-10-10 11:00
Wow, Jonathan, An impressive portrait. It looks like a classical oil painting portrait. Good to have the frame to this picture. Well use of the light and excellent clarity. Well done.
coco (30439) 2005-10-10 11:30
Hi Jonathan.
Excellent. I like very much this portrait. The way as the old man is watching something is great. And you has captured the MOMENT.
Also you has done a good job with the postprocessing.
toni_al (15875) 2005-10-10 18:07
Hi Jonathan
Simplement magnifique portrait.
perryhooter (2424) 2005-10-10 19:26
Hello Jonathan !
Beautiful portrait. Well done
I simply wish your model is still alive after the recent earthquake .
faubry (35447) 2005-10-12 3:29
very beautiful portrait, he seams me at Masoud... very good colors and sharpness, thanks
Aazragi (1927) 2005-10-12 12:31
Wow, what a classic shot. great composition and lighting on face of an old man. Well done.
jrj (34843) 2005-10-14 6:50
Strong portrait, well made compo in the tight setting. Very good work J.
gebala (0) 2005-10-19 14:33
hello, this photo is exellent, what a pose of this old man, what a beauty face,great shot, rgs
HI Jonathon great notes explaining how you took this fine image,wonderful skin tones and very pleasing colours.
Well done and TFS.
journeywood (195) 2005-11-08 13:35
His expression is fascinating. It looks like he's up to something clever. The glow in his eyes in wonderful. I looked at the original and the post-processing is very well done.
ccooper (840) 2005-11-25 20:15
The detail and character of his face are quite intriguing and well shown in this photograph. I like his quizzical expression and the multiple hues of his eyes. This is a wonderful portrait.
verswe (7330) 2005-11-27 16:43
Great shot.I like the composition and point of view.I like the expression of the man.Good colors,light,textures and sharpness.Very good job, Jonathan.
fadingstar78 (420) 2005-12-19 6:01
yes, the cropping makes the picutre a bit too focused on the face. but it's a great portrait! what do you mean by "shoot from the hip"? exactly?
grat pic and note! and thanks for the workshop...
maurazos (0) 2006-01-11 4:30
Wow! You've found Osama Bin Laden! (it's a joke!). Impressive portrait, full of details and skin textures. Regards.
sergio1 (12152) 2006-01-17 10:45
Hola Jonathan
Muy buena toma si seńor. La expresion de la cara es genial con su larga barba. Excelente nitidez.
keribar (43841) 2006-01-25 1:48
Helo Jonathan,
I like the way you framed tightly the face and turban of this man. The thick frame also gives us the impression that we look through a window: A picture I would have like to be taken.
Bets regards - Izzet Keribar
just4iris (792) 2006-02-24 7:11
Well, Jonathan, it's really a great portrait!
AmiBe (6042) 2006-05-20 15:45
Hi Jonathan,
it's very strange that I haven't commented this picture before...
A really good portrait.
I like his surprised face.
The light on his face is excellent, good contrast with the dark background.
Well done
jassy (1065) 2006-07-06 23:50
This image just blows me away. It is a very rivetting shot. But then when one looks at the original and realizes how the original was rather interesting but not remarkable and how you were able to see and emphasize this wonderful face, well.... You have a marvelous eye and I commend you.
prezntime (3946) 2006-07-27 16:44
What an amazing portrait. His look holds so much emotion and age. You managed to keep the picture very sharp and the smaller size really doesn't matter at all. Fantastic job.
rmatthews (945) 2006-07-27 20:06
Very nice...great tone, great content, very well done.
stefi (1230) 2006-09-29 14:32
Hi Jonathan, this portrait is really great, reminds me some from Steve McCurry. The PP is also really well made.
Only a bit soft on the eyes, but it's hard to get more with an hip shot.
hi jonathan
i think the shot is very good i also see ben laden in the mans face a very old ben laden at that but you could not have asked for better with the shot
sedaeristurk (457) 2007-04-11 8:43
Hi Jonathan,
I like most the look of the man.Very nice capture.TFS.Seda
diverjohn (544) 2007-06-21 10:05
I think this is one of those occasions where the man's fear of tourist-with-camera shows on his face, and that expression makes his image so endearing to us.
manatee (4668) 2007-07-04 12:10
Exelent portrait, I like the frame too, the only thing I add is the end of hi beard.
Congratulations you made a nice work and both ws are amazing
Wandering_Dan (3449) 2008-03-29 11:34
Hello, Jonathan -
This is an incredible portrait, the more so for being a hip shot. The clarity and the expression are amazing.
zahoor_salmi (1053) 2008-10-30 10:30 [Comment]
Emile (20352) 2009-05-18 21:28
Superb portrait Jonathan, I will place it in my favorites, sorry you left TE.
Best regards
azizbilgili (2111) 2011-03-30 2:38
Hi Jonathan,
Great shot.I like the composition and point of view.
Photo Information
- Copyright: Jonathan Wilson (jbweasle) (9393)
- Genre: Ludzie
- Medium: Kolorowe
- Date Taken: 2005-08-15
- Categories: Życie codzienne
- Camera: Nikon D70, 18-70 1:3.5-4.5 DX
- Naświetlenie: f/4.5, 1/250 sekund
- Wersja zdjęcia: Oryginalna wersja, Workshop
- Dzienniki z podróży: Afghanistan and Pakistan
- Temat(y): Your Favourite Pics, CLODO's SELECTION XIV [view contributor(s)]
- Date Submitted: 2005-10-09 6:05
- Ulubione: 4 [Widok]
- To donluicu: Have you seen... (1)
by jbweasle, last updated 2005-10-09 07:59
- To danielswalsh: Workshop (1)
by jbweasle, last updated 2005-10-09 09:24
- To nwoehnl: How to shoot from the hip... (1)
by jbweasle, last updated 2005-10-09 01:13
- To fadingstar78: Shooting from the hip (1)
by jbweasle, last updated 2005-12-19 06:54
- To Emile: Just resting (1)
by jbweasle, last updated 2009-06-10 06:27


text:
From Proteopedia
Structural highlights
[INS_HUMAN] Defects in INS are the cause of familial hyperproinsulinemia (FHPRI) [MIM:176730].[1] [2] [3] [4] Defects in INS are a cause of diabetes mellitus insulin-dependent type 2 (IDDM2) [MIM:125852]. IDDM2 is a multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.[5] Defects in INS are a cause of diabetes mellitus permanent neonatal (PNDM) [MIM:606176]. PNDM is a rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.[6] [7] Defects in INS are a cause of maturity-onset diabetes of the young type 10 (MODY10) [MIM:613370]. MODY10 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.[8] [9] [10]
[INS_HUMAN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The addition of phenols to hexameric insulin solutions produces a particularly stable hexamer, resulting from a rearrangement in which residues B1-B8 change from an extended conformation (T-state) to form an alpha-helix (R-state). The R-state is, in part, stabilized by nonpolar interactions between the phenolic molecule and residue B5 His at the dimer-dimer interface. The B5 His --> Tyr mutant human insulin was constructed to see if the tyrosine side chain would mimic the effect of phenol binding in the hexamer and induce the R-state. In partial support of this hypothesis, the molecule crystallized as a half-helical hexamer (T(3)R(3)) in conditions that conventionally promote the fully nonhelical (T6) form. As expected, in the presence of phenol or resorcinol, the B5 Tyr hexamers adopt the fully helical (R6) conformation. Molecular modeling calculations were performed to investigate the conformational preference of the T-state B5 Tyr side chain in the T(3)R(3) form, this side chain being associated with structural perturbations of the A7-A10 loop in an adjacent hexamer. For an isolated dimer, several different orientations of the side chain were found, which were close in energy and readily interconvertible. In the crystal environment only one of these conformations remains low in energy; this conformation corresponds to that observed in the crystal structure. This suggests that packing constraints around residue B5 Tyr result in the observed structural rearrangements. Thus, rather than promoting the R-state in a manner analogous to phenol, the mutation appears to destabilize the T-state. These studies highlight the role of B5 His in determining hexamer conformation and in mediating crystal packing interactions, properties that are likely be important in vivo.
Structural consequences of the B5 histidine --> tyrosine mutation in human insulin characterized by X-ray crystallography and conformational analysis.,Tang L, Whittingham JL, Verma CS, Caves LS, Dodson GG Biochemistry. 1999 Sep 14;38(37):12041-51. PMID:10508408[11]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also


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The Baby and All Bag is the changing bag with a hidden secret. It comes with a brilliantly simple integrated baby carrier. As your changing bag it has all the features you would expect and then it exceeds your expectations and gives you a baby carrier as well.
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"I've been totally blown away by how fantastic it is, and I'm not the only one - star rating : 5/5 (and that still isn't enough !)
Madhouse Family Review
We are so sure that you will love our bags that we are happy to offer you free delivery and a no quibble 14 day money back guarentee!
"I really can't recommend this bag enough. Such a clever idea that it's a wonder it wasn't invented before! "
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text:
Whitney Tilson, of T2 Partners, does a great job explaining the trouble that the FHA is in, but joins the brainless in praising the bailouts of the banking system. When will people see that it is these very bailouts that have caused the mess to begin with? At the end, the interviewer nails him on this point, but he simply does not get the cause and effect. The "utter calamity" that he thinks the government avoided is going to be a certainty because of people who think like that.
At any rate, Tilson explains that the FHA has gone from being only 2% of the mortgage market to now being over a quarter! AND, the default rate of FHA loans is soaring, the '07 vintage are already at a 32% delinquency rate! Thus, Whitney explains, the FHA is likely to become the next bailout using your dollars and future earnings. Yet another Trillion dollar disaster brought to you by your own government.
The Next Big Bailout? FHA Facing "Cataclysmic" Default Rates
Schedule for Week of December 6, 2020
2 hours ago