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Zika virus (ZIKV) is a teratogenic mosquito-borne flavivirus which can be sexually transmitted from man to woman. High viral loads and prolonged viral shedding in semen suggest that ZIKV replicates within the human male genital tract, but its target organs are unknown. Using ex vivo infection of organotypic cultures, we demonstrated here that ZIKV replicates in human testicular tissue and infects a broad range of cell types, including germ cells, which we also identified as infected in the semen from ZIKV-infected donors. ZIKV had no major deleterious effect on the morphology and hormonal production of the human testis explants. Infection induced a broad antiviral response but no interferon up-regulation and minimal pro-inflammatory response in testis explants, with no cytopathic effect. Finally, we studied ZIKV infection in mouse testis, and compared it to human infection. This study provides key insights into how ZIKV may persist in semen and alter semen parameters, as well as a valuable tool for testing antiviral agents.
Giulia Matusali, Laurent Houzet, Anne-Pascale Satie, Dominique Mahé, Florence Aubry, Thérèse Couderc, Julie Frouard, Salomé Bourgeau, Karim Bensalah, Sylvain Lavoué, Guillaume Joguet, Louis Bujan, André Cabié, Gleide F. Avelar, Marc Lecuit, Anna Le Tortorec, Nathalie Dejucq-Rainsford
Kaposi's sarcoma–associated herpesvirus (KSHV) is a gammaherpesvirus that is the etiological agent of the endothelial cell cancer Kaposi's sarcoma (KS) and 2 B cell lymphoproliferative disorders, primary effusion lymphoma (PEL) and multicentric Castleman's disease (MCD). KSHV ORF36, also known as viral protein kinase (vPK), is a viral serine/threonine kinase. We previously reported that KSHV vPK enhances cell proliferation and mimics cellular S6 kinase to phosphorylate ribosomal protein S6, a protein involved in protein synthesis. We created a mouse model to analyze the function of vPK in vivo. We believe this is the first mouse tumor model of a viral kinase encoded by a pathogenic human virus. We observed increased B cell activation in the vPK transgenic mice compared with normal mice. We also found that, over time, vPK transgenic mice developed a B cell hyperproliferative disorder and/or a high-grade B cell non-Hodgkin lymphoma at a greatly increased incidence compared with littermate controls. This mouse model shows that a viral protein kinase is capable of promoting B cell activation and proliferation as well as augmenting lymphomagenesis in vivo and may therefore contribute to the development of viral cancers.
Penny M. Anders, Nathan D. Montgomery, Stephanie A. Montgomery, Aadra P. Bhatt, Dirk P. Dittmer, Blossom Damania
The discovery of an HIV-1 cure remains a medical challenge because the virus rebounds quickly after the cessation of combination antiretroviral drug therapy (cART). Here, we investigate the potential of an engineered tandem bi-specific broadly neutralizing antibody (bs-bnAb) as an innovative product for HIV-1 prophylactic and therapeutic interventions. We discovered that by preserving two scFv binding domains of each parental bnAb, a single-gene-encoded tandem bs-bnAb, namely BiIA-SG, displayed significantly improved breadth and potency. BiIA-SG neutralized all 124 HIV-1 pseudotyped viruses tested, including global subtypes/recombinant forms, transmitted/founder viruses, and variants less or not susceptible to parental and many bnAbs, with an average IC50 value of 0.073 µ/ml (range < 0.001 to 1.03 µg/ml). In humanized mice, an injection of BiIA-SG conferred sterile protection when administered prior to challenges with diverse live HIV-1 stains. Moreover, while BiIA-SG delayed viral rebound in a short-term therapeutic setting when combined with cART, a single injection of AAV-transferred BiIA-SG gene resulted dose-dependently in prolonged in vivo expression of BiIA-SG, which was associated with complete viremia control and subsequent elimination of infected cells in humanized mice. These results warrant the clinical development of BiIA-SG as a promising bs-bnAb-based biomedical intervention for prevention and treatment of HIV-1 infections.
Xilin Wu, Jia Guo, Mengyue Niu, Minghui An, Li Liu, Hui Wang, Xia Jin, Qi Zhang, Ka Shing Lam, Tongjin Wu, Hua Wang, Qian Wang, Yanhua Du, Jingjing Li, Lin Cheng, Hang Ying Tang, Hong Shang, Linqi Zhang, Paul Zhou, Zhiwei Chen
Recent findings have highlighted the role of microglia in orchestrating normal development and refining neural network connectivity in the healthy CNS. Microglia are not only vital cells in maintaining CNS homeostasis, but also respond to injury, infection, and disease by undergoing proliferation and changes in transcription and morphology. A better understanding of the specific role of microglia in responding to viral infection is complicated by the presence of nonmicroglial myeloid cells with potentially overlapping function in the healthy brain and by the rapid infiltration of hematopoietic myeloid cells into the brain in diseased states. Here, we used an inhibitor of colony-stimulating factor 1 receptor (CSF1R) that depletes microglia to examine the specific roles of microglia in response to infection with the mouse hepatitis virus (MHV), a neurotropic coronavirus. Our results show that microglia were required during the early days after infection to limit MHV replication and subsequent morbidity and lethality. Additionally, microglia depletion resulted in ineffective T cell responses. These results reveal nonredundant, critical roles for microglia in the early innate and virus-specific T cell responses and for subsequent host protection from viral encephalitis.
D. Lori Wheeler, Alan Sariol, David K. Meyerholz, Stanley Perlman
Primary immunodeficiencies are often monogenic disorders characterized by vulnerability to specific infectious pathogens. Here, we performed whole-exome sequencing of a patient with disseminated Mycobacterium tuberculosis, Streptococcus viridians bacteremia, and cytomegalovirus (CMV) viremia and identified mutations in 2 genes that regulate distinct IFN pathways. The patient had a homozygous frameshift deletion in IFNGR2, which encodes the signal transducing chain of the IFN-γ receptor, that resulted in minimal protein expression and abolished downstream signaling. The patient also harbored a homozygous deletion in IFNAR1 (IFNAR1*557Gluext*46), which encodes the IFN-α receptor signaling subunit. The IFNAR1*557Gluext*46 resulted in replacement of the stop codon with 46 additional codons at the C-terminus. The level of IFNAR1*557Gluext*46 mutant protein expressed in patient fibroblasts was comparable to levels of WT IFNAR1 in control fibroblasts. IFN-α–induced signaling was impaired in the patient fibroblasts, as evidenced by decreased STAT1/STAT2 phosphorylation, nuclear translocation of STAT1, and expression of IFN-α–stimulated genes critical for CMV immunity. Pretreatment with IFN-α failed to suppress CMV protein expression in patient fibroblasts, whereas expression of WT IFNAR1 restored IFN-α–mediated suppression of CMV. This study identifies a human IFNAR1 mutation and describes a digenic immunodeficiency specific to type I and type II IFNs.
Rodrigo Hoyos-Bachiloglu, Janet Chou, Catherine N. Sodroski, Abdallah Beano, Wayne Bainter, Magdalena Angelova, Eman Al Idrissi, Murad K. Habazi, Hamza Ali Alghamdi, Fahd Almanjomi, Mohamed Al Shehri, Nagi Elsidig, Morsi Alaa Eldin, David M. Knipe, Mofareh AlZahrani, Raif S. Geha
Ebolaviruses and marburgviruses belong to the family Filoviridae and cause high lethality in infected patients. There are currently no licensed filovirus vaccines or antiviral therapies. The development of broad-spectrum therapies against members of the Marburgvirus genus, including Marburg virus (MARV) and Ravn virus (RAVV), is difficult because of substantial sequence variability. RNAi therapeutics offer a potential solution, as identification of conserved target nucleotide sequences may confer activity across marburgvirus variants. Here, we assessed the therapeutic efficacy of lipid nanoparticle (LNP) delivery of a single nucleoprotein–targeting (NP-targeting) siRNA in nonhuman primates at advanced stages of MARV or RAVV disease to mimic cases in which patients begin treatment for fulminant disease. Sixteen rhesus monkeys were lethally infected with MARV or RAVV and treated with NP siRNA-LNP, with MARV-infected animals beginning treatment four or five days after infection and RAVV-infected animals starting treatment three or six days after infection. While all untreated animals succumbed to disease, NP siRNA-LNP treatment conferred 100% survival of RAVV-infected macaques, even when treatment began just 1 day prior to the death of the control animals. In MARV-infected animals, day-4 treatment initiation resulted in 100% survival, and day-5 treatment resulted in 50% survival. These results identify a single siRNA therapeutic that provides broad-spectrum protection against both MARV and RAVV.
Emily P. Thi, Chad E. Mire, Amy C.H. Lee, Joan B. Geisbert, Raul Ursic-Bedoya, Krystle N. Agans, Marjorie Robbins, Daniel J. Deer, Robert W. Cross, Andrew S. Kondratowicz, Karla A. Fenton, Ian MacLachlan, Thomas W. Geisbert
Herpes simplex virus–1 (HSV-1) is the most common cause of sporadic viral encephalitis, which can be lethal or result in severe neurological defects even with antiviral therapy. While HSV-1 causes encephalitis in spite of HSV-1–specific humoral and cellular immunity, the mechanism by which HSV-1 evades the immune system in the central nervous system (CNS) remains unknown. Here we describe a strategy by which HSV-1 avoids immune targeting in the CNS. The HSV-1 UL13 kinase promotes evasion of HSV-1–specific CD8+ T cell accumulation in infection sites by downregulating expression of the CD8+ T cell attractant chemokine CXCL9 in the CNS of infected mice, leading to increased HSV-1 mortality due to encephalitis. Direct injection of CXCL9 into the CNS infection site enhanced HSV-1–specific CD8+ T cell accumulation, leading to marked improvements in the survival of infected mice. This previously uncharacterized strategy for HSV-1 evasion of CD8+ T cell accumulation in the CNS has important implications for understanding the pathogenesis and clinical treatment of HSV-1 encephalitis.
Naoto Koyanagi, Takahiko Imai, Keiko Shindo, Ayuko Sato, Wataru Fujii, Takeshi Ichinohe, Naoki Takemura, Shigeru Kakuta, Satoshi Uematsu, Hiroshi Kiyono, Yuhei Maruzuru, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
It remains controversial whether current antiretroviral therapy (ART) fully suppresses the cycles of HIV replication and viral evolution in vivo. If replication persists in sanctuary sites such as the lymph nodes, a high priority should be placed on improving ART regimes to target these sites. To investigate the question of ongoing viral replication on current ART regimens, we analyzed HIV populations in longitudinal samples from 10 HIV-1–infected children who initiated ART when viral diversity was low. Eight children started ART at less than ten months of age and showed suppression of plasma viremia for seven to nine years. Two children had uncontrolled viremia for fifteen and thirty months, respectively, before viremia suppression, and served as positive controls for HIV replication and evolution. These latter 2 children showed clear evidence of virus evolution, whereas multiple methods of analysis bore no evidence of virus evolution in any of the 8 children with viremia suppression on ART. Phylogenetic trees simulated with the recently reported evolutionary rate of HIV-1 on ART of 6 × 10–4 substitutions/site/month bore no resemblance to the observed data. Taken together, these data refute the concept that ongoing HIV replication is common with ART and is the major barrier to curing HIV-1 infection.
Gert U. Van Zyl, Mary Grace Katusiime, Ann Wiegand, William R. McManus, Michael J. Bale, Elias K. Halvas, Brian Luke, Valerie F. Boltz, Jonathan Spindler, Barbara Laughton, Susan Engelbrecht, John M. Coffin, Mark F. Cotton, Wei Shao, John W. Mellors, Mary F. Kearney
Seneca Valley virus (SVV) is an oncolytic picornavirus with selective tropism for neuroendocrine cancers. It has shown promise as a cancer therapeutic in preclinical studies and early-phase clinical trials. Here, we have identified anthrax toxin receptor 1 (ANTXR1) as the receptor for SVV using genome-wide loss-of-function screens. ANTXR1 is necessary for permissivity in vitro and in vivo. However, robust SVV replication requires an additional innate immune defect. We found that SVV interacts directly and specifically with ANTXR1, that this interaction is required for SVV binding to permissive cells, and that ANTXR1 expression is necessary and sufficient for infection in cell lines with decreased expression of antiviral IFN genes at baseline. Finally, we identified the region of the SVV capsid that is responsible for receptor recognition using cryoelectron microscopy of the SVV-ANTXR1-Fc complex. These studies identify ANTXR1, a class of receptor that is shared by a mammalian virus and a bacterial toxin, as the cellular receptor for SVV.
Linde A. Miles, Laura N. Burga, Eric E. Gardner, Mihnea Bostina, John T. Poirier, Charles M. Rudin
Chronic viral infections are difficult to treat, and new approaches are needed, particularly those aimed at reducing reactivation by enhancing immune responses. Herpes simplex virus (HSV) establishes latency and reactivates frequently, and breakthrough reactivation can occur despite suppressive antiviral therapy. Virus-specific T cells are important to control HSV, and proliferation of activated T cells requires increased metabolism of glutamine. Here, we found that supplementation with oral glutamine reduced virus reactivation in latently HSV-1–infected mice and HSV-2–infected guinea pigs. Transcriptome analysis of trigeminal ganglia from latently HSV-1–infected, glutamine-treated WT mice showed upregulation of several IFN-γ–inducible genes. In contrast to WT mice, supplemental glutamine was ineffective in reducing the rate of HSV-1 reactivation in latently HSV-1–infected IFN-γ–KO mice. Mice treated with glutamine also had higher numbers of HSV-specific IFN-γ–producing CD8 T cells in latently infected ganglia. Thus, glutamine may enhance the IFN-γ–associated immune response and reduce the rate of reactivation of latent virus infection.
Kening Wang, Yo Hoshino, Kennichi Dowdell, Marta Bosch-Marce, Timothy G. Myers, Mayra Sarmiento, Lesley Pesnicak, Philip R. Krause, Jeffrey I. Cohen
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Q. In your last column you referred to walls that weren't nailed together correctly, but I didn't understand what was supposed to be done to avoid cracks in the walls. Is there a particular way that it's done to avoid the problems you described?
A. Many architects' building plans have adopted the nailing schedule from the building codes that prescribes the size and number of fasteners to be used for each type of connection in the wood framing process. For example, in my last column I wrote about how the wall base plate, a 2x4, was nailed to each of the vertical wall studs with one nail, straight through the bottom of the 2x4 base plate and into the bottom of the wall studs. It would be like jamming the stud down onto a small spike. By doing so, the wall stud has the ability to rotate, like an axle.
Once everything is nailed together to form the wall frame, it seems as sturdy as what would have been the correct way, which is to have at least two nails going into the base of the wall stud, at an angle on one side of the stud, and at least one nail on the opposite side. You don't want to use more nails, because the wood can split. The difference is that the grain of the wood runs with the length of the wall stud and ends at the top and bottom of the stud.
The grain is like a series of straws bundled together very tightly, and once served as the feeding tubes, or capillaries, for the tree. So nailing parallel, up into those straws, versus nailing across them, at an angle, is much weaker. As the wood continues the drying process over the years, subjected to interior changes in humidity from changes of season, air conditioning, heating, etc., there is internal movement in the wood.
I've explained in previous columns that when the market for lumber is really good because construction is booming, not all lumber gets the proper time to dry before shipping or installation. When it's nailed correctly, you stand a better chance of minimizing the movement of the lumber at the most critical joints. End-grain nailing is a weak connection, and not prescribed in the building codes.
There are many factors that play into the continuous movement of buildings, and from experience, testing, observation and practice, the construction industry has evolved to become very effective at making buildings stronger, safer and more flexible in the face of changing needs. Unfortunately, there are many who never bother to pick up a book or search on their phone for the prescribed way to build. One building department even posts pictures on the wall at its counter of the "violation of the month," and leaves them up alongside the next and the next. It's a great way to show the public how not to do things. I hope I nailed it.
© 2019 Monte Leeper. Readers are encouraged to send questions to firstname.lastname@example.com, with "Herald question" in the subject line, or to Herald Homes, 2 Endo Blvd., Garden City, NY 11530, Attn: Monte Leeper, architect.

subset: commoncrawl


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The record will be sold in the Forest for £5.
We will distro to Mono, Avalanche, Fopp, Analog and possibly others. The cost of the record will be enough to make sure we get at least £4 per record and will be decided on a piece by piece basis depending how much the various shops wants to take in commission.
Action - Dan will talk to these places
We would like to do a launch party in Mono as well as here. This will depend when various people are free. Like the Pendulums and Mikey.
Action - Dan will talk to the Pendulums/Mono.
We need a press release
Action - Jane will write one
We need a website
Action - Gareth will make one
We need to send lots of records to various people, possibly including Bucks Fizz and Phil Spector and the manager of the Bay City Rollers
Action - start a BB thread
We give one copy each to Mikey, Pendulums, Dirk, Crave, Jane, Dan, Dai, Gareth and Magda. Further copies can be purchased for cost price.
Launch party (n.b. will not be on a farm). Hopefully the Saturday 13th of the Blender Redux weekend, because then we'll have booze and goodness and dancing.
Actions - Dan will contact the Pendulums, Dai will talk to Mikey, Jane will email Meth//Markham.
Next Meeting, Tuesday September 11th. We'll make more inside covers and put some records together and write numbers on them. Hopefully all these actions will be done by then too, pleasey.
Action - Jane will make a poster asking people to come help
this is all
Meating Minutes
Records, publishing, shop etc.
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Meating Minutes
"We all tend to idealise kindness and tolerance, then wonder why we find ourselves infested with losers and nutcases." Sebastian Horsley
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Kasabian's Serge Pizzorno has come out fighting in Oasis' corner after mainman Noely G was attacked by Elton John.
Commenting to The Sun following Elton's comments that Noel was "an absolute twat who looks like Parker from Thunderbirds", Serge asserted that:
"Elton's just a fat man in a tracksuit. Whereas anything that comes out of Noel's mouth is absolute genius.
"Noel is the last man you want to start with. He's so quick he can destroy anyone. Elton needs to watch out."
Yeah! Watch out Elton! Or Noel will come round to your mansion and beat yo' ass! He might even attack you in a London park.
Elton has also this morning been announced on the bill for a Princess Diana memorial concert to take place at Wembley Stadium next summer. 'Cause obviously there's a chance we'd have forgotten her by then.


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Hey Crushies,
It was brought to my attention today that we where on Tosh.0! The dvd "Nightmare on Twink Street" was featured last night on either the show or his blog! Thats so awesome to be on a major TV shows blog/show to be made fun of! Check out Tosh.0 Blog to check it out!


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In this rare photo, the Rebbe can be seen while reciting "Shema" during Ma'ariv, in the upstairs Zal of 770.
Tags: Photography, The Rebbe
Laibel Orenstein – Crown Heights to Rochel Aboutboul – Rio de Janeiro, Brazil
L'Chaim: Tuesday Night at FREE
Zalman Denburg – Coral Springs, FL to Chanie Gorkin – Crown Heights
L'Chaim: Tonight (Tuesday) at FREE
Levi Milworn – Crown Heights to Faigy Donin – Crown Heights. L'Chaim: Tonight (Thursday) Oholei Torah Hall
Moshe Coleman – Crown Heights/London to Simcha Davoudpour – Beverly Hills, CA
Baby boy to Raffy and Chana Filler (nee Stein) – Crown Heights
Sholom Ber Liberow (Ben R' Zalman) – Flatbush, NY to Chaya Braun (Bas Harav Yosef Yeshaya) – Crown Heights
Mendel Fayershteyn – Crown Heights to Gitty Lipszyc – Ft. Lauderdale, FL L'Chaim: Monday Night at the Oholei Torah Hall
The Yeshiva originally from Wilkes-Barre, now located in the Pocono Mountains but still affectionately known by it's old location held special Farbrengens to mark Tes and Yud Kislev on their beautiful new campus • Photos
The Bochurim in the Lubavitch Yeshiva of Tzfas hosted and organized a banquet for Shluchim to unite in bringing Moshiach with a number of special presentations and Rabbonim and Mashpiim addressing those assembled there • Photos
Online chinuch can provide unique stability and even comes with advantages, such as the increased focus of teachers on each individual student, yet it can also have tremendous pitfalls. Knowing how to make it work and what dangers to avoid at all cost is key to success. At a time when online options may be the most stable, we need to enhance chinuch and avoid dangers. Online chinuch is often a lifesaver, yet a child must be protected from destruction • Full Story
With great sadness, we regret to inform you of the passing of Mrs. Estelle Chazan, of New Jersey. She passed away on Friday, Yud Alef Kislev. She was 86-years-old • Full Story


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WEST virginia legislature
2017 regular session
Senate Bill 629
By Senator Boso
[Introduced March 16, 2017;
to the Committee on Government Organization; and then to the Committee on Finance]
A BILL to amend and reenact §15-5A-5 of the Code of West Virginia, 1931, as amended, relating to collection of Tier II fees for chemical inventories.
Be it enacted by the Legislature of West Virginia:
That §15-5A-5 of the Code of West Virginia, 1931, as amended, be amended and reenacted to read as follows:
§15-5A-5. Powers and duties of the commission.
The commission shall have and may exercise the following powers and authority and shall perform the following duties:
(a) Designate emergency planning districts;
(b) Appoint local emergency planning committees for each emergency planning district and supervise and coordinate the activities of such committees;
(c) Revise any designations and appointments made under subsections (a) and (b) of this section as it deems appropriate: Provided, That any interested person may petition the state emergency response commission to modify the membership of a local emergency planning commission;
(d) Designate, if necessary, additional facilities which shall be subject to the requirements of this article, provided such designation is made after public notice and opportunity for comment as provided under article three, chapter twenty-nine-a of the code;
(e) Review the emergency response plans submitted by the local emergency planning committees and make recommendations to the local committees on revisions of the plan that may be necessary to ensure coordination of such plan with the plans of other emergency planning districts and other existing state and local emergency response plans;
(f) Enter into cooperative agreements with other state agencies designating specific responsibilities to be performed by such state agencies to implement the provisions of this article;
(g) Promulgate procedural rules in accordance with the provisions of article three, chapter twenty-nine-a of this code, establishing rules of practice before the commission;
(h) Promulgate procedural rules in accordance with the provisions of article three, chapter twenty-nine-a of this code, establishing procedures for receiving and processing requests from the public for information in accordance with the provisions of 42 U.S.C. §11001, et seq., and this article, and prescribing forms and instructions for requesting such information;
(i) Promulgate procedural rules in accordance with the provisions of article three, chapter twenty-nine-a of this code, prescribing forms and instructions for the submission and receipt of confidential information;
(j) Promulgate rules establishing the following fees which shall be deposited in a special account for the administration of this act and which shall be reasonably calculated to recover the necessary expenses incurred by the Office of Emergency Services in the administration of this article:
(1) An emergency planning
notification fee not to exceed
$100 $200 to be paid by a facility
when it makes the emergency planning notification required under SARA, Title
III, sections 301 through 303;
(2) An inventory form fee
not to exceed
$100 $2,500 to be paid annually by a facility when
it submits the emergency and hazardous chemical inventory forms or material
safety data sheet required under SARA, Title III, sections 311 and 312; and
(3) A surcharge fee not to exceed twenty percent of the fee otherwise payable to be paid by facilities which fail to pay the fees in paragraphs (1) and (2) in a timely manner;
(k) Establish an emergency planning grant program to be administered by the commission. The grant programs will be funded by fees collected to administer this act pursuant to subdivision (j) of this section. The commission shall promulgate rules which establish the method of awarding such grants to local emergency planning committees to assist them in performing their responsibilities under this article;
(l) Promulgate legislative rules in accordance with the provisions of article three, chapter twenty-nine-a of this code necessary to implement the provisions of this article; and
(m) The chairman of the commission may order a facility owner or operator to comply with the requirements of applicable federal law, this article and any rules or regulations promulgated thereunder. When the chairman has reasonable cause to believe that there exists a failure to comply with the provisions of applicable federal law, this article or any rule or regulation promulgated thereunder or any order entered by the chairman, he or she may request the Attorney General to commence an action for civil penalties, injunctive relief or other appropriate relief to enforce such provisions, rules and regulations or order. Such action may be brought in any federal district court having jurisdiction, or in the Circuit Court of Kanawha County or the county where the facility or a major portion thereof is located.
NOTE: The purpose of this bill is to increase the cap mandated on the collection of Tier II fees for chemical inventories.
Strike-throughs indicate language that would be stricken from a heading or the present law and underscoring indicates new language that would be added.


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Green Central Knoll
Green Central Knoll Playground
Shakespeare once asked, "What's in a nameΑ" In the case of parks, a name often reflects the history of the place and the spirit of the time when the park was named. Many small parks were named after local World War I heroes during the 1930s and early '40s, recalling acts of courage in the midst of troubled times. Others are named after prominent local figures, allowing the deceased to remain an important part of the community. Some derive their name from a previous owner of the property, others from local streets. Green Central Knoll Playground's name is unusual in that it combines the names of all three streets that bound it: Evergreen Avenue, Central Avenue, and Knoll Street. Evergreen was so named because it led to the Cemetery of the Evergreens. Central drew its name from its once-central location within the community, while Knoll was named after a local businessman.
The neighborhood of Bushwick dates back to 1638, when Dutch settlers purchased the land from the Canarsie Indians. Peter Stuyvesant (1610-1672), the legendary Dutch governor, chartered the area in 1661 and named it Boswyck, meaning "refuge in the woods" or "heavy woods." Farms that produced food and tobacco for local consumption originally dominated the area. The economy evolved, and by the late 19th and early 20th centuries the area was dominated by breweries, the most famous of which were Rheingold and Schlitz.
This specific playground was once the site of the Rheingold Brewery. In 1855, Samuel Liebmann, a German immigrant, founded its forerunner, Liebmann Breweries, which his sons took over upon his death in 1872. The sons expanded the business, buying and consolidating several smaller brewing companies, and in the 1880s, Rheingold became the company's premier brand. The firm continued to grow, and between 1940 and 1965 it ran a famous promotional beauty contest, in which customers cast ballots to select Miss Rheingold.
Despite its glamorous image, the brewery was unable to compete with a national spirits trade that boasted massive advertising budgets, state-of-the-art facilities, and national distribution systems. In 1964, the Liebmann family sold the brewery to Pepsi-Cola United Bottlers, who renamed it Rheingold Brewery. Sales continued to decline, and it was sold to Chock Full O'Nuts in 1974. The Brooklyn factory closed in 1976, and in 1977, the Rheingold Brewery was bought by C. Schmidt and Sons, a Philadelphia firm who soon left the business.
After the factory closed, it was taken over by the City for non-payment of taxes in 1979, and was designated for commercial development in 1980. However, the property's proximity to P.S. 145, combined with local demand for a ballfield, dictated otherwise. In 1997, the Department of Citywide Administration Services assigned the property to Parks, and Parks developed the site.
In the last few years, Borough President Howard Golden sponsored a $2,961,000 multi-phased reconstruction project that produced a beautifully manicured baseball field, play equipment with safety surfacing, a sitting area with plantings, benches, a bear sculpture, a drinking fountain, and a decorative gate. The playground design reflects a nautical theme with a Parks flag perched on a yardarm and mast located at the highest point. Water runs from this area through a rocky stream bed. The stream has brass casts of fish, such as perch, trout and bass. The stream meanders downward to the park's lower end where the water pours into a catch basin adjacent to an area adorned with spray showers. The park has since become a popular gathering place for children and adults from the neighborhood to play, talk, or just to sit and enjoy the greenery.


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by Arundhati Roy
Rockefeller to Mandela, Vedanta to Anna Hazare…. How long can the cardinals of corporate gospel buy up our protests?
by Arundhati Roy
Rockefeller to Mandela, Vedanta to Anna Hazare…. How long can the cardinals of corporate gospel buy up our protests?
4.1 Following the shift in favour of imperialism in the international correlation of class forces, USA has embarked to consolidate its global hegemony by achieving its three declared objectives.
4.2 The first seeks the dissolution of the remaining socialist countries; the second, to render impotent either through defeat or co-option, third world nationalism, which materialized the Non-Aligned Movement following the decolonisation process; and, finally, the establishment of an unequivocal and unambiguous military and economic superiority over the world in general and particularly over perceived competitors.
4.3 This new world order is designed to operate in all spheres. [15] This, on the one hand, led to unleashing unilateral wars and the military occupation of Iraq. On the other hand, it led to the strengthening of the US military machine. [16] At the same time, the NATO, whose need for existence should have simply disappeared with the end of the Cold War, was further strengthened as imperialism's global war machine. Continue reading
People's Voice, Vancouver Bureau
For years, Canadians have been told that "the Taliban are on the back foot" and that victory is near in Afghanistan. Most of us never believed it. Opinion surveys have consistently shown that the majority of Canadians want our troops brought home from this unwinnable war.
The latest news from Kabul confirms that the US-led occupation forces have utterly lost the battle for popular support. Contingents of NATO troops are being pulled out ahead of schedule, with the notable exception of Canada.
The spark for this development was lit when U.S. troops on clean-up duty tossed Korans into a burning pit at Bagram Air Base. Afghan workers rescued some singed pages, and before long, massive protests and riots shook the country. A swift round of apologies and promises by U.S. officials has done nothing to change the mood of an increasingly resentful Afghan public.
A decade after taking on the "colonial burden", the U.S. and its allies are paying the political price for an endless string of abuses, torture and killings committed in the name of "freedom". Before long, the remaining occupation troops may be inside their giant fortified bases, chowing down on expensive western-style fast food. As in Iraq, they may be replaced by western "civilians", but the signs of imperialist retreat are everywhere.
About 300 U.S. and other NATO advisors were withdrawn from Afghan ministries around Kabul in late February, as fears mounted for their safety. At the same time, the German military decided to speed up plans to abandon a 50-soldier outpost in the north of the country.
The French are also eager to get out since four of their troops were killed (and 16 wounded) by an Afghan army soldier, just weeks after three others were shot by another Afghan in uniform. Both the French and the Germans have also withdrawn civilian advisors from Afghan government institutions.
As Tom Engelhardt and Nick Turse wrote in the Tom Dispatch blog on Feb. 28, "Eleven years in, if your forces are still burning Korans in a deeply religious Muslim country, it's way too late and you should go." Instead, General John R. Allen, the war commander in Afghanistan, has directed that all U.S. military personnel undergo ten days of sensitivity training in the proper handling of religious materials.
Sensitivity, as Engelhardt and Turse point out, has not been an American strong suit. They point to revelations about the 12-soldier "kill team" that murdered Afghan civilians "for sport," and then posed for photos with the corpses. Four U.S. Marines videotaped themselves urinating on the bodies of dead Afghans. A U.S. sniper unit proudly sported a Nazi SS banner in another incident, and a U.S. combat outpost was named "Aryan." British soldiers were filmed abusing children. Eight shepherd boys, aged six to 18, were recently slaughtered in a NATO air strike in Kapisa Province in northern Afghanistan. Afghans have endured years of night raids by special operations forces that break into their homes, violating cultural boundaries and often killing civilians.
These actions have been protested by President Hamid Karzai, who has little power over his own country. And now, more than 30 protesters have been killed in demonstrations against the burning of the Korans.
The New York Times now reports that Afghanistan is "a religious country fed up with foreigners". Laura King of the Los Angeles Times writes about the "visceral distaste for Western behaviour and values" among significant numbers of Afghans.
Engelhardt and Turse provide details of the blowback against the NATO forces. In a heavily guarded room of the Afghan Interior Ministry in Kabul, the bodies of a U.S. lieutenant colonel and major were recently found, each executed with a shot in the back of the head while at work.
Two other U.S. troops died outside a small American base in Nangarhar Province in the midst of a demonstration in which two protestors were also killed. An Afghan soldier gunned the Americans down and then escaped into the crowd.
In fact, Afghans in police and army uniforms have repeatedly attacked their "allies". At least 36 U.S. and NATO troops have been killed this way in the past year, far beyond the level of "isolated incidents." This includes the April 2011 case in which an Afghan air force colonel murdered nine U.S. trainers in a heavily guarded area of Kabul International Airport. His funeral was attended by 1,500 mourners.
The time for "apologies" by the U.S. occupation forces has long passed. Many Afghans are demanding local trials and the death penalty for the Koran burners.
Engelhardt and Turse conclude, "despite its massive firepower and staggering base structure in Afghanistan, actual power is visibly slipping away from the United States. American officials are already talking about not panicking (which indicates that panic is indeed in the air). And in an election year, with the Obama administration's options desperately limited and what goals it had fast disappearing, it can only brace itself and hope to limp through until November 2012.
"The end game in Afghanistan has, it seems, come into view, and after all these fruitless, bloody years, it couldn't be sadder. Saddest of all, so much of the blood spilled has been for purposes, if they ever made any sense, that have long since disappeared into the fog of history."
For Canadians, this terrible tragedy includes 158 deaths among our own troops. When Afghanistan inevitably bids goodbye to NATO, our politicians will be asked: what was it all for? And there is no good answer.
*note: the above article is from the March 16-31, 2012, issue of People's Voice, Canada's leading communist newspaper. Articles can be reprinted free if the source is credited. Subscription rates in Canada: $30/year, or $15 low income rate; for U.S. readers – $45 US per year; other overseas readers – $45 US or $50 CDN per year. Send to People's Voice, c/o PV Business Manager, 706 Clark Drive, Vancouver, BC, V5L 3J1.


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Entries are submitted to the HuDSeN database using the official gene name, according to the HUGO Gene Nomenclature Committee, at the time of uploading. If an official gene name subsequently changes after submission of the entry to the database, the previous name may be shown in the table above.
Copyright ©The Medical Research Council & University of Newcastle
All Rights Reserved.


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Although this issue has been addressed in this post some months ago: Thiessen Polygon delineation within a Feature, the appropriate answer has not been given. So, new ideas are welcome.
How can we use the Create Thiessen Polygons (Analysis) tool available with ArcInfo license by defining an external feature boundary (e.g. study area boundaries defined by a polygon) for the created thiessen polygons?
As I have seen this is not possible via the Environments...options in that tool.
Is there any available code in VBA for doing this? or How can I run this tool within a VBA code?
The comments indicate that ArcGIS 9.2 and 9.3 is being used, the tag indicates version 10, the first post is for that version not previous ones.


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VET is HTML5, responsive template for Veterinarians, Animal Clinic and similar.
Templace contains 13 HTML files and PHP file for submit forms. If you like this template, please rate it !
Main features
- Shop – products list (with alternative version),
single product, cart and checkout,
- 100% responsive
- Working Appointment form (landing page)
- Working Contact form
- Approximate time with timepicker – compatible with
two time types (12h with "am" and "pm" and 24h),
- Opening hours table
- Sortable Gallery with custom, unique slideshow plugin
- Blog
- Three versions of single blog post, with comments
- Shortcodes – alert box, buttons, pricing table
- Google Map
- Clients references
If you have any problems with this template or have any questions, please send me an email – firstname.lastname@example.com. Moreover, template contains extensive documentation.
– Animate.css by Dan Eden
– jQuery Cycle 2 plugin by malsup
– Isotope by David DeSandro / Metafizzy
– jQuery
– jQuery UI
– $.noUiSlider by LeonGersen
– Signika from Google Fonts Directory
– all icons are from flaticon
Images used in Preview
– all from Photodune, not included to main downloaded file


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The Typographer as Reader
|The dimensions of graphic design – as a profession and as a field of study- are endlessly debatable, its boundaries notoriously fuzzy.
And the position of typography within graphic design education is even more fluid, subject to a wide range of preconceptions, orthodoxies and multiple interpretations.
Typography has in 20 years developed, socially and culturally, from being a very specialised body of knowledge to a democratised, public and domestic medium.
Patterns of technological change support the view that rather than being a sub-genre within graphic design, typography is the larger and more far reaching discipline, graphic design the specialism. Much typography exists outside of graphic design,
but there is very little graphic design that is independent of typography.
Typography is increasingly being practiced by non-designers, and decisions we would in the past have seen as the province of specialists are being applied by a whole spectrum of visual artists – as well as administrators, secretarial staff, schoolchildren.
It follows from these changes that we should ask new questions about typography in education, and question whether the precepts which have served in the past are still applicable.
What pedagogical model do we apply to the study of typography?
What methods are best suited to developing awareness as well as skill?
In order to answer this, we need first to look at the range of perceptions brought to the subject in the past.
In the mid sixties Emil Ruder said:
|In 1972, Wolfgang Weingart listed these three elements as comprising the correct typography education:
|So: in the altered conditions of the twenty-first century, we may need to step back from some of the assumptions we grew up with and ask again the question: what is typography? And how do we teach it?
Is it: an expressive medium, situated within the educational context of art and design?
Defined by abstract values: rhythm, tonality, form, dots and lines
|Is it a pragmatic functional tool, to which one might apply the criteria and methodologies of engineering or industrial design?
Is it a medium of cultural interpretation, situated within the humanities?
Of course, it is all these things and more.
|I'd suggest that the most useful insight into its current condition, and the contradictions which surround its relationship to the wider context of 'Design', may be found in the fact that graphic design is unique among art and design disciplines in its relationship to written language. Laurie Haycock Makela has said that
|I'd identify this 'separation' as a defining characteristic, fundamental to defining the way forward for typography within design education.


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Does Kodo use any caching?
Yes. Kodo has two levels of caching. The first is a per-session cache that is mandated by the specification. Kodo also provides a level 2 data cache that can be shared by multiple sessions and has the capability of synchronizing across a distributed system. See Section 10.1, "Data Cache".
Is Kodo faster than JDBC?
A Kodo application will typically outperform a generic JDBC application, since Kodo is able to able to efficiently batch together like operations at commit time, eliminate redundant SQL, and and perform sophisticated caching. Since Kodo runs atop a JDBC driver, it will never be able to communicate with the database any faster than the JDBC driver can. However, for any operations beyond the most simplistic JDBC program, Kodo will dramatically increase the performance of the application beyond what is possible using raw JDBC.
Is Kodo faster than EJB 2 Entity Beans?
It is only meaningful to compare the performance of Kodo with that of CMP Entity Beans. While the performance of CMP beans varies depending on the application server being used, they will almost always be slower than using plain Java objects, since plain objects does not incur the heavy method invocation overhead that penalizes all EJBs.
How can I speed up my Kodo application?
Kodo provides a wide variety of configuration options and API extensions to fine tune your applications performance. For an overview of common optimization techniques, see Chapter 15, Optimization Guidelines.
How can I profile the performance of my application?
Kodo provides a sophisticated set of management tools to analyze the behavior and performance of your application. See Chapter 12, Management and Monitoring and Chapter 13, Profiling. Also, Kodo can be used in all popular profiling applications such as OptimizeIt or JProbe.
Can I customize the fields that Kodo loads when an object is first instantiated from the database?
Yes. Kodo allows the definition of custom fetch groups, which enable the application to dynamically specify which fields to instantiate eagerly. See Section 5.6, "Fetch Groups".
When I traverse a relation, Kodo issues a separate statement to the database. How can I ensure that the relation is always loaded immediately?
Relations, like any other fields, can be added to the default fetch group, which will cause Kodo to attempt to efficiently traverse the relation when the owning persistent instance is first instantiated from the database. See Section 5.7, "Eager Fetching".
Does Kodo utilize connection pooling?
Kodo provides its own built-in connection pooling
framework. Additionally, Kodo can be integrated with
any third-party connection pool that implements the


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a friend of mine Sunny is looking for places to tour in europe, his shows are amazing. If you have suggestions or want to help him put on a show in edinburgh that'd be awesome. Go to his website http://www.sunnydrake.com and let him know!
Looking to tour later this year, 2013 and 2014. Basic info below about the shows, workshops I can run as well as the sorts of spaces I'd like to perform. More info is attached as well.
Both shows look at serious topics in light-hearted/accessible ways including analyses of race, gender, class etc. Both shows have been super well received by LGBTQI2-S as well broader non-queer audiences.
<<ABOUT "X" (60 minutes)>>
Stop motion animation, puppetry and live performance meld in this fast-paced one-man show, a tongue-in-cheek exploration of quick fixes and fixations hard to quit.
Booze. Facebook. Sex. Carbs. Fess Up: what's your guilty pleasure? X is your window into the whimsical world of two best friends and two puppets searching for an escape from reality. But what happens when even the escape becomes a nightmare? When an absurd new government law aiming to clean up the world from alcoholics comes into effect, will they escape their escape?
Magical, absurd, tender & humorous, X provides insight into the complexities and struggles of alcohol in peoples' lives, as well as touching on other addictions.
<<ABOUT "OTHER-WISE" (60 minutes)>>
A gutsy convention-defying one-person show weaving theatre, magical animation, movement, puppets, comedy & multimedia.
Other-wise is a letter to Sunny's family come to life on the stage, exposing his emotions and experiences as a transgender person. Animated creatures whisk us into worlds of magic as Sunny explores boy tits, being honest with one's family, transgender history, learning to fly and getting comfortable with contradictions and not knowing.
Cities, big & small towns… I'm open to small audiences in small towns! I don't judge success by audience numbers. The shows work best in theatres, but can also be performed in other venues such as classrooms, warehouses, town halls and youth centers (I have my own tourable lighting).
* Must have minimal external light interference (e.g. windows will need to be covered)
* Intimate sized spaces (under 100 seats) are best as the puppets are small.
* Minimum dimensions of "stage" area: Depth 4.5m (15 ft) x Width 3.5m (11.5ft) x Height 2.5m (8.5ft)
>> more tech specs/requirements attached.
* Theatres -local, national and international festivals: theatre festivals, queer, transgender, multi-artform festivals
* Colleges - looking for personal contacts, suggestions or advocating with particular universities/colleges e.g. theatre departments, queer groups, PIRGS, social justice groups...
* Young people's spaces:
- High schools (most suitable for years 11 and 12. Unlikely to suit ultra conservative schools!) Could be hosted by the theatre dept (e.g. part of an autobiographical or solo performance subject), a GSA, social studies class etc.
-Youth centres/ organisations: LGBTQI2-S, addiction related or broader young people
*Conferences - could be the evening educational entertainment for addiction, mental health, queer, transgender, health workers, therapists, social workers... (along with a daytime workshop)
* Warehouses, Town halls, art galleries...
Workshops can be hands-on or information based and range from 1 hour to multi-day. Workshop focuses include:
• Artist Q&A
• Creating autobiographical and/or community researched performance
• One person/solo performance
• Creative writing
• Creating multi-genre theatre, particularly incorporating multimedia
• Self-producing and touring independent work
• Addiction (with a preference to co-facilitate with a qualified addictions counsellor)
• Transgender and/or queer, lesbian, gay, bisexual, intersex education
I have available:
- Dvd of each show ("Otherwise" dvd ready now, "X" dvd ready in about 2 weeks!)
- Short online video promo ("Otherwise" promo- see http://www.sunnydrake.com , "X" promo- ready in about 1 week!)
- Presenters package attached including: longer description of the shows, press quotes, artist biographies, full list of tech specifications, to a history of each show etc
Also checkout my website if you're interested: http://www.sunnydrake.com


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By Chuck Inman
Todd had a good sales background and was having a successful year until his product went on backorder for six weeks due to a packaging problem. Finally, the problem was corrected, the product was back on the market, and he was anxious to get his customers using it again.
His biggest customer, Ben, owned two franchises, and when Todd asked if he was ready to start using his product again he was surprised by the answer. Ben flat out said he wasn't interested in Todd's product anymore and that he had begun using the competition's product. Todd had worked hard on this account over the past year and he had kept Ben up to date on what was happening with the backorder situation and all the work that Todd had been doing dealing with the backorder. Todd thought maybe he should drop his price in order to get his business back with Ben.
When Todd talked with Ben and suggested a price cut, Ben told him that price wasn't the problem. Ben was upset because during the backorder situation, Todd had not even inquired about what the backorder was doing to Ben's business. Instead, every time Todd met and talked with Ben it was always about how Todd had been affected by the backorder. Because Todd focused on his situation he failed to notice how the backorder of his product had caused a major disruption for his customer's business.
Here's the real crux: Ben quit doing business with Todd because he didn't feel valued and didn't feel that Todd had his best interests in mind. When people don't feel that there is a connection, they don't feel valued and that important foundation of trust becomes shattered. It is a difficult challenge to regain that trust with a customer and build the relationship back to a healthy win-win scenario.
A good definition of clout is "the power to influence people or events." Customer Connect with CLOUT is the ability to influence customers in a sales situation where the customer understands what their life will be like in the future from utilizing your product or service. It is the ability to understand your customer's needs and help them understand that the best way to satisfy that need is through your offering.
Here are the key areas to help you provide Customer Connect with CLOUT:
Clarity: Truly understand the value of the product or service you provide and how it will impact your customer or customer's business. Once this is understood, then it becomes easier to help the customer see what is needed for them to become more successful and how to fill that void or need. By selling the experiences and benefits you get to the real reason people buy. The real reasons are more than just specific features or price. The real reasons have an emotional attachment because it is the solution to a problem for your customer.
Learning: This is key in discovering everything you can about your customer and your competition. If your customer has a business, how do they view their business and what do they consider being a successful business? If you customer has a need, what is a satisfactory way of fulfilling that need and then what is an over-the-top way of fulfilling that need? What products or services do your competitors provide and how do they bundle or package these? Also, learn about the skills you need to be successful by taking advantage of training opportunities and reading and listening to books, DVDs and articles on how to connect, influence and sell.
Openness: It's not just about selling a product or service, but being open to new ideas to help customers solve their problems and fill their needs. Customers may have certain needs today but try and anticipate what those needs may be or how the situation may change one to two years from now? Be open to viewing the customer's situation as it really is, not just how you perceive it or how you would like it to be.
Understanding: Understand what motivates your customer. What is their vision about a satisfactory result? Great opportunities come from being genuinely interested in your customers. Ask the right questions, the more difficult high-value questions that provide you with key insight about your customers and their needs such as: "What specifically would you consider a great result or solution?" or "Why would that have an impact?" Then sit back and listen. To truly understand it takes a developed listening skill to hear what your customer is trying to tell you. Instead of providing information, you listen and acquire information that will help you connect with your customer and be able to meet their needs.
Trust: This is the foundation to selling and developing strong relationships with customers. To build strong relationships and connect with your customers, you have to believe in your product or service and you have to believe in yourself. More importantly, your customers need to believe in you and be able to trust you. The trust comes from following up on what you say you are going to do. Line up your actions with your intentions and have the impact on your customers that you need for that long-term relationship. This will be the impact that provides the solutions for your customer's best interest and needs.
Connecting with customers takes hard work. It takes vision, confidence, curiosity, passion and integrity. Remember it's not all about you but rather what you can do for your customer in satisfying their needs, wants, voids and concerns. When you can satisfy those items, your customers feel valued and connected which goes a long way in developing long-term beneficial relationships.
Chuck Inman is a leadership and emotional intelligence specialist. He is a keynote speaker, trainer, coach and founder of Crystal Clear Motivation, LLC. His leading edge keynote on "Leadership C.L.O.U.T. – Improving Communication Skills & Strengthening Teams," is a dynamic program that's addresses leader's key challenges in today's world. He has traveled across multiple continents and presented his programs to people from over 40 different countries. To find out more information about Chuck and his programs please visit www.chuckInman.com.


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Christopher Adler, PhD
Professor, Music
- PhD, Duke University, Composition
- MA, Duke University, Composition
- BA, Massachusetts Institute of Technology, Music Composition
- BA, Massachusetts Institute of Technology, Mathematics
Christopher Adler, PhD, is a composer, performer and improviser. His music draws upon over a decade of research into the traditional musics of Thailand and Laos and a background in mathematics. He is a foremost performer of new and traditional music for the khaen, a free-reed mouth organ from Laos and Northeast Thailand. As Director of Composition for the nief-norf Summer Festival, pianist for the nief-norf Project and the ensemble NOISE, and co-founder of the soundON Festival of Modern Music, he is active in commissioning and performing new works, and he performs and records as an improviser on piano in many ensembles.
Adler studied:
Composition with Scott Lindroth, Stephen Jaffe, Sidney Corbett, Evan Ziporyn
Thai music with Panya Roongruang
Pipe organ with James David Christie and Haig Mardirosian.
Scholarly Work
Adler's compositions encompass cross-culturally hybrid forms drawn from contemporary concert music and traditional musics of Thailand and Laos, algorithmic composition, and the integration of improvisation into structured composition. His works have been performed at Carnegie Hall, Chicago Symphony Center, Tanglewood, Merkin Hall, Shanghai Symphony Hall, the Seoul Arts Center, Sumida Triphony Hall in Tokyo and at new music festivals and universities across the U.S. by ensembles including the Silk Road Ensemble, red fish blue fish, Ensemble ACJW, the Da Capo Chamber Players, and many others. His compositions have been released on Tzadik, Innova, Rattle, Blue Leaf, Blue Griffin, and WGBH's Art of the States. As the world's leading innovator in the creation and performance of contemporary khaen repertoire, he has performed his own compositions and traditional repertoire at venues including Carnegie Hall, the Bang on a Can Marathon, Music at the Anthology, and the Cultural Center of Chicago. He is pianist and composer-in-residence with the chamber ensemble NOISE and co-director of the annual soundON Festival of Modern Music. His performances and improvisations have been released on Tzadik Records, Innova Recordings, Vienna Modern Masters, pfMENTUM, Nine Winds, Traditional Crossroads and Circumvention/Accretions.
Areas of Interest
Adler offers a wide variety of courses in music theory, composition, sound art and world music. In addition to directing the music composition area in the Music Program, he collaborates with the Department of Art, Architecture + Art History in the Art+Intermedia area in which students integrate creative work with critical scholarship on the contemporary arts in diverse media. Adler also contributes to the Honors Program with a course on music and religion in South and Southeast Asia.
Asian Studies
College of Arts and Sciences
Contact Us Email
Visit Campus Map
5998 Alcalá Park
San Diego, CA 92110


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The Wii translation of Dead Space will do one thing right, at the very least—it will support the Wii MotionPlus peripheral for one-to-one motion tracking, making first-person shooting that much easier.
That was confirmed by Electronic Arts Chief Operating Officer John Pleasants during his talk at the Goldman Sachs Technology and Internet Conference 2009, who also talked up Dead Space Extraction's zero-gravity Necromorph dismemberment. Fun!
But if the notion of playing Dead Space with a Wii remote in an on-rails shooter setting doesn't quite do it for you, consider this. It's not so much an on-rails shooter as it is a "guided first person experience." Doesn't that sound lovely? GFPX, here we come!
All new details on Dead Space Extraction can be absorbed at MTV's new interview with Steve Papoutsis, Executive Producer on the Wii title, including mention of drop-in two-player coop.
EA Confirms MotionPlus Support for 'Dead Space' Wii [GameCyte]
'Dead Space Extraction' Dev Says Wii Is 'Very Powerful,' Classifies Game As A 'Guided First Person Experience' [MTV Multiplayer]


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New York City's Premier Center for Cosmetic Dentistry
We would like to welcome you to The New York Center for Cosmetic Dentistry, New York's Premier Smile Design and Smile Restoration Center. We have created smiles that are some of the most celebrated and photographed of our times. At The New York Center for Cosmetic Dentistry, we treat all sorts of people from regular folks to celebrated folks, yet we do not see any "ordinary" people. Each person is extraordinary in his or her own way. Each moment of time, each appointment, is valued as unique. Each client is special, and brings her/his singular image aspiration, cultural bias, hopes and dreams of a better smile. It is our collective generosity of spirit in the office that enables us to maintain an "expectation of excellence" each and every hour of each and every day. Every one of our patients/clients has a made a choice to entrust us with their complete cosmetic makeover or mild enhancement, and we honor that choice.
Our memorable smiles have adorned over five hundred magazine covers, have appeared in countless films and TV episodes, have been seen delivering the news around the world and have sold billions of dollars of products. If you are looking for an individualized smile, a complete smile makeover or just a mild enhancement, we have been exclusively focused on improving and restoring smiles for more than 40 years. Using bonding, Whitening, Porcelain Veneers, Implants, Invisalign and Crowns, we will target your image aspiration to achieve the look you want— whether it is sexy, sporty, romantic, athletic or sophisticated. Our doctors combine their artistic and technical excellence with superior communication skills and a level of compassion that is rare in the health services. Our nurturing, welcoming staff is without parallel in providing five-star service and support. We continue to see clients from The New York Metropolitan Area to across the United States and around the world. Our office is fluent in French, Spanish, Russian, Hebrew, Albanian, and Serbian-Croatian.
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Governments, private sector, and civil society actors will be able to use this Centre to learn from each other's experiences, identify people and partners with critical expertise, plan ahead, and design programmes and policies.
Rio de Janeiro, Brazil (PRWEB) June 22, 2012
As a major and concrete legacy of the Rio+20 Conference, the Brazilian Government announced the creation of Rio+ Centre, the World Centre for Sustainable Development, at a ceremony this morning attended by Izabella Teixeira, Brazil's Minister for the Environment and Helen Clark, United Nations Development Programme (UNDP) Administrator.
The Rio+ Centre will facilitate research, knowledge exchange and promote international debate about sustainable development. It will bring together a broad international consortium of partners, consisting of government agencies, United Nations agencies, local governments (including the state government and municipality of Rio de Janeiro), NGOs, universities, think-tanks and the private sector.
"For us it's really important to have a legacy here after Rio+20, in the city of Rio de Janeiro. Our universities, various sectors of society, the business community and everyone here wants to work hard for this legacy,'' announced Minister Teixeira, and added that $5 million in seed money for the Centre's operations had already been secured.
UNDP Administrator Helen Clark, welcomed the partnership: "Brazil's President Dilma Rousseff has said that not only is it possible to grow and to include, protect, and conserve at the same time, but also truly sustainable development requires that we do so, and at UNDP we believe the same thing."
"Governments, private sector, and civil society actors will be able to use this Centre to learn from each other's experiences, identify people and partners with critical expertise, plan ahead, and design programmes and policies. UNDP can contribute with its extensive networks of experience and expertise to this new Centre. We have a long history of capacity development support, and an established role as an impartial broker who can connect sustainable development initiatives that need to go up scale," Helen Clark noted.
At the moment of its launch, the Rio+ Centre counts on the support of nearly 25 Brazilian and international institutions, which displays the success achieved by the initiative, as well as the inclusive and participatory nature of its conception.
Luciano Coutinho, President of Brazil's Development Bank (Banco Nacional de Desenvolvimento Econômico e Social, BNDES) stated that "BNDES joins the Brazilian government in supporting the Rio+ Centre and welcomes the UNDP and other partner institutions in this important initiative arising from Rio+20. It will create a unique space for discussion of innovative ideas and actions for building a sustainable world."
According to the official announcement of Brazil's Ministry of External Relations, the Rio+ Centre "is born with the mission to be a main reference centre for the promotion of one of the defining debates of this century: the integration between the economic, social and environmental dimensions of sustainable development."
The objective behind the creation of the Rio+ Centre is to build on new and innovative mechanisms for engaging the participation of local governments, civil society, business and academia in knowledge exchange and discussions around the subject.
From the outset, the Rio+ Centre will provide continuity to the discussions launched by the Rio Dialogues for Sustainable Development (http://www.riodialogues.com). The Dialogues were launched by the Government of Brazil with the support of UNDP in the lead-up to Rio+20 as a way of actively ensuring inputs of civil society and experts worldwide.
The new centre will build on the successful existing partnership between the Government of Brazil and UNDP: the International Policy Centre for Inclusive Growth (IPC-IG), established in 2004, in Brasilia. Since its founding, IPC-IG has been playing a key role in the dialogue between countries of the South on policies for social protection and inclusion, development innovation as well as rural and sustainable development issues.
The Rio+ Centre facilities will be initially hosted by Federal University of Rio de Janeiro's Institute of Graduate Studies and Research in Engineering (COPPE/UFRJ), at the Ilha do Fundão Campus. Rio's Municipality has stated its willingness to provide a space for the future headquarters of Rio+ Centre.
The establishment of the Rio+ Centre initially received support from the following institutions:
- United Nations Development Programme (UNDP)
- United Nations Environment Programme (UNEP)
- International Policy Centre for Inclusive Growth (IPC-IG)
- United Nations Programme for Human Settlements (UN-HABITAT)
- International Labour Organisation (ILO)
- Institute of Advanced Studies, United Nations University (UNU-IAS)
- Regional Centre of Expertise in Education for Sustainable Development (RCE)
- Government of the Federative Republic of Brazil
- State Government of Rio de Janeiro
- Municipality of Rio de Janeiro
- Financier of Studies and Projects (FINEP)
- Banco Nacional de Desenvolvimento Economico e Social (BNDES)
- Center for Strategic Studies and Management (CGEE)
- Global Institute for Green Technologies and Employment (GIGTech, COPPE / UFRJ)
- Center for Sustainable Development at the University of Brasilia (UNB-CDS )
- FGV Network of Technology and Innovation of Rio de Janeiro (REDETEC)
- Technological Information Network Latin America (RITLA / UNESCO)
- National Confederation of Industry Brazil (CNI)
- Brazilian Service to Support Micro and Small Enterprises (Sebrae)
- Brazilian Business Council for Development (CEBDS)
- Brazilian Foundation for Sustainable Development (FBDS)
- BVRio (Bolsa Verde Rio)
- Reverurbano
- Pro-Natura Foundation
UNDP partners with people at all levels of society to help build nations that can withstand crisis, and drive and sustain the kind of growth that improves the quality of life for everyone. On the ground in 177 countries and territories, we offer global perspective and local insight to help empower lives and build resilient nations. http://www.undp.org. Follow us on twitter and facebook.


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CHARLOTTESVILLE, VA -- A judge has dismissed a lawsuit filed in May by a group of for-profit club owners in the Charlottesville, VA, area who claimed that Albemarle County acted unfairly when it allocated $2.03 million in public funds toward building a new YMCA facility, according to several media outlets.
The Charlottesville Area Fitness Club Owners' Association (CAFCOA), which represents ACAC Fitness and Wellness Centers, Gold's Gym and Total Performance Sports and Fitness, argued that the county violated the Virginia Public Procurement Act by not allowing private clubs to bid on the aquatic services that will be offered by the YMCA's new center or to make alternative proposals to building the facility on public land.
"The association fully supports the mission of the YMCA and its contributions to our community," the CAFCOA said in a media statement when it filed suit in May. "However, we do not feel that constructing a large-scale fitness center is the best use of taxpayer dollars. Given the current economic climate, we believe that appropriating $3 million for the construction of a 70,000-square-foot fitness facility in McIntire Park is a misuse of public funds—especially when other providers are in a position to offer solutions that cost less and can prevent the destruction of a public park."
Judge Cheryl Higgins decided for the county, which argued that because its contribution was to a nonprofit organization, it was not subject to the requirements of the procurement act.
In a media statement after the ruling, the CAFCOA said it respectfully disagreed with the ruling.
"While we agree that Albemarle County had the power to make appropriations to charities, we think the judge was in error in finding that the county could contract for the acquisition of services without also complying with the Virginia Public Procurement Act," the CAFCOA said in the statement. "Although we are disappointed with the outcome, we appreciate the right to participate in the judicial process and will weigh our options going forward."
The CAFCOA also filed suit in May against the city of Charlottesville, which allocated an additional $1.25 million toward building the new facility and agreed to a 40-year lease of public park land to the Y for $1 per year. The suit has been assigned to the same judge, but no date has been set for the hearing.
The YMCA is not a party to either lawsuit.


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Savage Gulf
State Park and Outdoor Recreation in Monteagle, TN
Purchased by the state in 1973 to protect one of the last known stands of virgin timber in the Eastern United States, Savage Gulf has 55 miles of trails and ten primitive campgrounds.
Hiking & Camping Info: (Click Here)
Maps: (Click Here)
The Savage Gulf Ranger Station is the eastern access point to the Savage Gulf-Stone Door trail system that traverses the most rugged and scenic areas of the South Cumberland complex. The Stone Door Ranger Station is within the Savage Gulf area and is accessible off State Highway 56 near Beersheba Springs. It is named for the Great Stone door, a 150-foot deep crevice at the crest of the Plateau. It is the western access for the Savage Gulf-Stone Door trails network.
Park Activities: (Click Here)


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Dirty little secrets of virtualization
- 28 April, 2011 07:45
This vendor-written tech primer has been edited by Network World to eliminate product promotion, but readers should note it will likely favor the submitter's approach.
The virtualized data center has accelerated the pace of operational change. Virtual machines are reconfigured, computing loads are moved, and applications are scaled up and down rapidly. We know that with rapid rates of change come high levels of mistakes; analysts estimate that 60 per cent to 80 per cent of data center problems are caused by management mistakes. How can you ensure the stability of your data center while at the same time taking maximum advantage of the flexibility of virtualization?
Virtualization promises to improve data center operations and indeed it does. Server consolidation has great benefits. The ability to migrate loads without stopping them greatly eases hardware management. The ability to deploy new virtual machines in a fraction of the time of a physical machine makes application development and deployment more rapid and effective.
ANALYSIS: Virtual server management demands strong policies, automation tools
However, the advantages of virtualization bring some associated costs. The hypervisor adds another level of complexity in the software stack and imposes requirements on the servers, the storage system, and especially on the network. While the hypervisor offers some automation for simplifying operations of servers, the environment around the virtual cluster was impacted without being made any simpler.
In a recent survey of Infoblox customers, 70 per cent reported that virtualization put more pressure on their network operations. It's easy to see the source of this pressure. Every virtualization initiative is surrounded by physical resources:
• Storage systems
• Users, workstations and partner networks
• Load balancers and security devices
• Remote peer servers
• Physical unvirtualized servers
• Competitive hypervisors that are not compatible
• Private clouds, laboratory systems and other specialized clusters
The boundary between each of these elements and the virtualized environment is a place where operational mistakes can be made. Both sides of the boundary matter; the hypervisor's configuration may be incorrect, or the external environment may be misconfigured. When a performance problem arises, information from both sides of the boundary must be integrated to find the solution.
When new applications are deployed, both sides must be validated in advance. Mistakes and inconsistencies will show up in three different ways: in application performance issues; in delays in operational procedures; or in inefficient operations that eat up staff time. Each data center will have its own pattern; here are some examples:
Application performance becomes poor or inconsistent
• Port and network access parameters can be mismatched. There are many parameters that impact performance, including port duplex, network QOS settings, firewall access lists and more.
• Rogue devices may be attached to the network, with incorrect IP numbers or incorrect protocol settings that disturb production devices.
• Configurations that "drift" from best practice, whenever manual procedures are followed incorrectly or when standards are incomplete. The result can be old and new devices with very different settings, producing erratic performance.
Requests for changes take too long
• When a virtual server will be migrated for updates or maintenance, its destination must have the right network settings. Manual setup adds delay, especially when compared to the near-instant speed of a virtual hot-migration.
• When a disaster recovery site is created, tested or updated, its network settings must be verified to match the master site. Manual verification adds delay.
• When new servers are added to scale up a load-balanced system, several devices may need carefully sequenced updates, including the physical switch, firewall and load balancer. Manual configuration adds delay, which is often much longer than the time it takes to spin up a new virtual server.
Staff wastes time in routine operations
• Daily tasks like IP address assignment must be coordinated. Mistakes can be hard to track down in a constantly changing environment.
• Troubleshooting problems often involves correlating logs and alerts from multiple sources. With virtualized systems, there's often a gap between the physical and virtual systems where data must be matched by hand.
• If an unauthorized person performs a move or change, time can be wasted rechecking the work (or even worse, fixing mistakes).
• Auditing and compliance reporting are a regular headache, and virtual systems can add complexity.
In a virtualized data center, the changes are more complex, and they occur more often thanks to the flexibility of virtual machines. Mistakes become more costly, and they may occur more frequently.
But there is a way to master the complexity and minimize the mistakes, and it doesn't require a complete infrastructure overhaul. The answer is augmenting existing infrastructure with automation.
If a configuration management platform can be embedded in the data center network, and if it can perform automated procedures, all of the issues above can be addressed.
An automated platform can be filled with "gold standard" configurations for all elements on the virtual system boundary. Deviations from those standards, whether from rogue devices or drifting configurations, can be prevented, isolated or repaired. The gold configurations can be applied in a single step, resulting in quick and consistent response to requested changes.
Troubleshooting can be accelerated when data from physical systems is correlated with data from virtual ones. Authorization and delegation rules can block unapproved changes and audit approved ones.
Automation is needed in the network around the hypervisor to realize the full benefits of virtual systems. A network resident data-center-wide platform for management and automation can minimize error, promote flexibility and cut the hidden costs of virtualization.
Infoblox is an industry leading developer of network infrastructure automation and control solutions. Infoblox's unique technologies, including the Infoblox Grid -- a real-time, data distribution technology -- increases network availability and control, while automating time-consuming manual tasks associated with network infrastructure services like domain name resolution (DNS), IP address management (IPAM), network change and configuration management (NCCM) and network discovery, among others.
Read more about infrastructure management in Network World's Infrastructure Management section.


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Forum: Addons
Topic: SilverSleek2 - Page: 1
Original Skin Forums topic is HERE
2015-04-29 Version 2.11:
Initial Release
2015-05-09 Version 2.12:
Fixed bug on clock and other text zones not rendering correctly on MAC
Fixed bug on Master VU-meter in top bar view. VU-meter will not be visible with external mixer setup anymore.
Added "Auto Cover/Digital" and "Auto Cover/Custom" options on jogs
Added Support for Pioneer DDJ-SP1 and DDJ-SR
Added option to always force 2nd HOTCUE layer to be hotcues 9-16
2015-05-21 Version 2.13:
Fixed bug when forcing Hotcues 9-16
Added second browser "Command Bar" toolbox alongside the custom buttons toolbox. The "search" actions require software build 2276 or greater.
2015-09-07 Version 2.15:
Added new 2 Decks Layout: "Essentials". Mainly for use with a controller connected.
Redesigned "Full Audio Mixer" central panel
Added Beat or Bars counter on scratch waveforms (optional)
Added 32 or 64 beat markers on progress waveforms
LCD font for decks is now included inside the zip in case it's missing from your system and you want to instal it
Minor bug fixes
2015-09-09 Version 2.16:
Added BeatKeeper on all views
Added 4 Decks Full Audio Mixer
Fixed an issue when selecting effects on slots
2016-02-11 Version 2.18:
Added optional Freestyler8 DMX control interface on top bar
Added cue and loop colors on pads
Added colored markers on progress waveforms
Fixed a few bugs with some padmodes
2016-02-24 Version 2.19:
Added new 2 decks layout "Phantom"
Inviato Wed 29 Apr 15 @ 3:07 pm
Inviato Thu 21 May 15 @ 2:36 am
PS: You can toggle 2 decks view with 4 decks view on the fly if you wish, but I know that's another story! ;)
Inviato Thu 21 May 15 @ 2:48 am
Maybe I missed it, but is there a TXT file to show all the features of the Skin?
Inviato Thu 21 May 15 @ 8:30 am
Some Guides will come soon...
Inviato Thu 21 May 15 @ 10:45 am
I´m trying this skin, and it is wonderfull! Great Job!
I have trouble with the Covers. I set the Option Cover to Yes and And the Jogs to Custom/Cover but neither i get covers showed left to the title nor on the jogs. I Tryed a lot of Songs, and all have covers, so what i´m doing wrong?
Could it be that my screen resolution is not enough? (1280x800)
Inviato Sat 30 May 15 @ 12:31 pm
Nice Work Bro
Tried A Dozen Of Skins For My Pioneer SZ And This It The Most Suitable One Of All
Really Gr8 Work And A Big Thx To You
PS: Can You Make The Jog-wheel Bigger As It Looks A Bit Small On Laptop Screen
Inviato Mon 01 Jun 15 @ 12:57 am
Inviato Mon 22 Jun 15 @ 1:58 am
it will be gr8 idea
Inviato Tue 23 Jun 15 @ 6:41 am
Inviato Thu 25 Jun 15 @ 1:30 pm
Regards, Thomas
Inviato Sun 05 Jul 15 @ 7:19 am
Inviato Thu 03 Sep 15 @ 6:54 pm
Inviato Mon 07 Sep 15 @ 5:51 am
Inviato Sun 27 Sep 15 @ 4:38 pm
Inviato Wed 30 Sep 15 @ 12:54 pm
user10593225 wrote :
hi, how can we add our custom logo to the jog wheels?
Check out this forum for your answer... http://www.virtualdj.com/forums/198178/VirtualDJ_Skins/_SilverSleek2.html?page=18
Inviato Mon 30 Nov 15 @ 2:34 am
Here are a couple of questions:
1. When not using a controller, is there a way to stop the TAB key from cycling through all 4 deck PFLs when in 2 deck mode? I know that there is a workaround script but I'm wondering if this can be a default setting where TAB functions as 2deck and 4 deck when in respective panels?
2. How do I activate the GROUP 1-4 Buttons in the center panel of the skin? Is this something I need to program or is there a Turn/ON/OFF feature I haven't found yet?
3. How do I saved a loop? I see where I can recall a loop but don't see an option to SAVE a loop.
Thank you for all of your work.
Inviato Sun 26 Jun 16 @ 4:46 am
Inviato Sun 26 Jun 16 @ 4:51 am
ProfLee wrote :
I forgot to mention that the following screen a happened after coming out Settings. The only way I could get everything back was to exit the program a resart.
Inviato Sun 26 Jun 16 @ 4:55 am
OJ_Skin Normal
the same with BigBrowser
and i like to change the SkinColour from dark to lightdark or grey .
Do you can help ?
greats from Germany
DJ Gerry
Inviato Mon 27 Jun 16 @ 11:44 am


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Storm chaser captures lightning's grandeur
Veteran photographer Lewis Surrey roamed San Diego County Friday, looking for lightning on a hot, humid, tempestuous day. He found what he was looking for; more than 550 lightning strikes were recorded in San Diego County. They grew out of 50,000-foot tall thunderstorms that produced more than one inch of rain in some areas and a fresh found of hail in Pine Valley.
Surrey came away with stunning images. We asked him to describe the experience. Here's what he said:
Live Oak Springs, which I did not know about until today, is an unincorporated part of SD county. It's next to Boulevard, or just south of that Acorn Casino on I-8, and west of Jacumba. I went there because that is where the today's storms could be viewed. I carry an iPad that has several weather radar apps. When more than two software models are in agreement of where the storms will track, off I go to that suggested location. It helps to be in a sunny area and the temperature above 95 and very high humidity. It's uncomfortable, but this is the best environment for storm growth.
I also look for billowing cumulus clouds that develop flat, dark bases. As soon as a rain core bursts through the base, you have a lightning pathway. You have to get to the approximate location in time (usually 11:30AM - 12 Noon), find a field or viewpoint without( hopefully) power or phone lines, and not be on private property. You have to be at least within 3 miles of the storm and not in front of the storm. Best to be off the west or east because monsoons always track North, Northwest, or Northeast.
Within 3 miles of the storm structure you can see the entire cloud structure and most of the lightning. That is where the storm is photogenic. But being that close is itself dangerous. Recent studies mention that the first bolt out of a cloud can travel up to 25 miles. If I am the tallest object around then I am in danger of being hit by a bolt. I set up the camera and then wait in the car, and use another camera to shoot from inside my vehicle. I have had several close calls (none here in SD) but I was always in the car or a structure.
If you arm hairs stand up or you feel tingling, or it starts raining, RUN!
Today's storm was one of several severe thunderstorms going through the county. I did see a lot of CG(cloud to ground) lightning, especially before I set up. Most monsoon storms here do not put out a lot of lightning, but these last few days are the exception. I probably caught 12 good shots today. My years of chasing and photographing tornados have given me the experience and knowledge to get out there and hopefully do this safely.
When it rains it pours - more photos coming.
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