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1. What's on for 2020 West Coast
Welcome to West Coast Futsal Association. Here is what's on offer for the 2020 year in Futsal: Click Here to Nominate a team or Yourself :) West Perth Futsal - 56 Smyth Rd, Nedlands P: 0432 745 140 E: firstname.lastname@example.com Monday: * Juniors - Gol Brasil Junior Academy * Seniors - Social Mixed A, B and C grades Tuesday: * Seniors - Social Men's B, C & D grade Wednesday: * Seniors - Social Men's A, B & C grade Thursday: * Juniors - Perth Futsal
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2. Festival of Futsal - Mandurah 2019
FESTIVAL OF FUTSAL - MANDURAH 2019: The annual 'West Coast Futsal Open' is on again. Held in beautiful Mandurah just a short 45 minute drive south of Perth. This tournament is held over the Easter long weekend with the emphasis being on lots of Futsal and lots of Fun : ) There is something for everyone Male, Female, Juniors and Seniors with 8 age categories to choose from. "NOMINATIONS NOW OPEN" WEST COAST
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3. Social Men's & Women's Comps - West Perth Futsal
Social Men's & Women's league are held every night during the week at West Perth Futsal. Fixtures are played between 6:20 pm and 9:40 pm, all skill levels catered for and games are always a lot of fun and social. Nominate yourself or a team and join the 5-a-side soccer action : ) West Perth Futsal is conveniently located a short drive west of the CBD in Nedlands, with games played
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4. Girls Only Futsal
St Mary's Futsal Club: Is Perth's first ever Girls Only Futsal Club. Located at St Mary's Anglican Girls School, Karrinyup we aim to help promote the sport of Futsal and introduce more females to enjoy the game of 5-a-side soccer. Competitions are held on Friday's with games played between 5:30 and 8:30 pm. The New Summer season of Futsal is underway with friendly games. Teams and individuals are invited to join with all skill levels
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5. Hollywood Tuesday 'Men's B & C'
NEW, NEW, NEW, Tuesday Men's B & C grade competition. Hollywood Futsal Club has vacancies for Teams and Individuals who are interested in playing regular 5-A-Side Soccer on a Tuesday Night. Games are played from 6 - 10 pm, we play outdoors on Artificial Grass under lights and and games are always a lot of Fun. There is a competition to suit all skill levels and abilities. We provide a very
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6. Winter Junior Futsal @ Scarborough
Scarborough Beach Futsal Club: New Winter season of Junior Futsal Starts soon. Competitions are held on Saturday's with games played between 10 am and 5 pm. On offer there are three age groups for both boys and girls. New for Winter 2017 – there will now be 3 junior age groups (i) 11 years & under, (ii) 13 years & under and (iii) 15 years & under. Teams and individuals are invited
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7. Gol Brasil Junior Development
Gol Brasil Futsal is a fun based Development Program aimed at improving individuals playing level. We use the game of futsal (5-a-side soccer), which encourages less physical contact and more touches on the ball, to improve individuals skills, technique and court awareness. We do this through game play and a variety of training techniques. Gol Brasil is recognised by CBF (Brazilian Football Association) who share the same philosophy of developing players. Boys
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7. West Coast Futsal - Promo
West Coast Futsal is Perth's ultimate 5-a-Side Futsal Association. Now at 5 great club locations around Perth. From Men's, Women's, Social Mixed, Supa-Liga (Elite) and Juniors. From beginners to advanced, from Social to Elite Players, all abilities and playing levels are covered. Grab 5 mates get in contact and come down for a game! http://www.youtube.com/watch?v=OzOtdsQFOSY
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Global and U.S. Consumer Confidence at Highest Levels Since 2007
Consumer Confidence Remains Flat in China; Increases in Europe
NEW YORK – Global consumer confidence returned to pre-recession levels with an index of 96 in the first quarter of 2014—the highest score since Q1 2007, according to consumer confidence findings from Nielsen, a leading global provider of information and insights into what consumers watch and buy. The global index—which recorded its lowest score of 77 in Q1 2009—represents a two-point increase from Q4 2013 and a three-point increase from a year ago (Q1 2013).
Across the world's six biggest economies, five demonstrated consumer confidence gains. Listed by the level of the increase, overall confidence increased eight points in France (59), six index points in the U.S. (100), four points in Germany (99), three points in the U.K. (87), one point in Japan (81) and remained flat in China (111). Consumer confidence in Japan and Germany are at the highest levels since 2005.
Regional consumer confidence was highest in Asia-Pacific with an index of 106, a one-point increase from the previous quarter (Q4 2013) and a three-point increase from a year ago (Q1 2013). North America posted the largest quarterly increase of five index points to reach the optimism baseline of 100—the highest level since 2007. The Middle East/Africa region increased four index points to 94, and Europe increased two index points to 75, compared to Q4 2013. Latin America reported the only quarterly regional consumer confidence decline of one index point to 93.
The Nielsen Global Survey of Consumer Confidence and Spending Intentions, established in 2005, measures consumer confidence, major concerns, and spending intentions among more than 30,000 respondents with Internet access[1] in 60 countries. Consumer confidence levels above and below a baseline of 100 indicate degrees of optimism and pessimism. In the latest round of the survey, conducted February 17 – March 7, 2014, consumer confidence increased in 60 percent of markets measured by Nielsen—up from 43 percent the previous quarter (Q4 2013).
Indonesia (124) reported the highest consumer confidence index for the fifth consecutive quarter. Croatia and Italy each reported the lowest consumer confidence index scores of 45, an increase of one point each compared to the previous quarter. Egypt (87) and Switzerland (104) reported the largest quarter-on-quarter index increases of 11 and 10 index points, respectively. Ukraine (56) reported the biggest quarterly index decline of seven points.
Global Job Outlook Improves
Positive perceptions about local job prospects over the next 12 months increased in the first quarter in every region except Latin America. Almost half of global respondents (49%) believed the job market would be good or excellent in the upcoming year, a quarterly increase of 2 percentage points, which brings the average to just below the pre-recession outlook of 50 percent. The biggest quarterly increase in job optimism came from North America, increasing 5 percentage points to 43 percent.
More than half (55%) of global respondents regarded their personal finances positively, a level that has held steady for three consecutive quarters. In Latin America and Asia-Pacific, respondents were most secure in money matters, with 63 and 62 percent, respectively, believing the state of their finances were good or excellent. European respondents were least confident about finances, with 57 percent saying their personal money situation was not good or bad.
Recessionary Sentiment Lingers
More than half of global respondents (55%) said they felt the effects of recession in the first quarter, but the sentiment was improved compared to 57 percent in the previous quarter. Regionally, recessionary sentiment improved most in North America, down 7 percentage points to 61 percent, the lowest level since the start of the recession (2007).
More than two-thirds (68%) of markets measured by Nielsen reported an improved recessionary sentiment compared to fourth-quarter 2013, with the steepest improvements in the United Arab Emirates (-11 percentage points), Switzerland (-11pp) and Peru (-10pp). Recessionary sentiment also improved by 9 percentage points in Mexico, Vietnam, Romania and New Zealand and by 8 points in the U.S. and the Netherlands.
Highlights from Around the World
In North America, U.S. savings and investing intentions picked up pace in the first quarter, with 44 percent of respondents putting spare cash into savings accounts, up from 39 percent in fourth-quarter 2013. Fifteen percent invested in stocks and mutual funds, up from 11 percent the previous quarter. More than one-third (36%) said they paid debts, credit cards and loans, a quarterly increase of 5 percentage points. U.S. discretionary spending intentions also increased across numerous categories, including new technology and out-of-home entertainment, which increased 4 and 3 percentage points, respectively, compared to fourth-quarter 2013.
In Europe, consumer confidence increased in 22 of 32 markets in the first quarter. Confidence in France (59) and Greece (53) increased eight index points each, and Portugal (51) and Spain (61) increased seven and three index points, respectively, compared to fourth-quarter 2013. Consumer confidence in Germany remained robust with an index score of 99, an increase of four points from the previous quarter.
Consumer confidence in Asia-Pacific increased in eight of 14 markets in the first quarter, was flat in three and declined in three. The region's biggest quarterly index increases were in India (121) and Hong Kong (111), increasing six index points each. India's index rise returns the score to a fourth-quarter 2012 level after several quarters of declining performance. Consumer confidence in the Philippines (116) and Thailand (108), as well as Indonesia (124) and China (111), were among the highest index scores of 60 countries measured.
Brazil led the Latin America region with the highest index of 106, which declined four points from fourth-quarter 2013. The biggest regional quarter-on-quarter consumer confidence index increases were in Mexico (86) and Venezuela (78), which rose eight and four index points, respectively. Conversely, consumer confidence in Argentina (71) declined six index points, while Chile (98) and Peru (101), each fell one index point, respectively, compared to fourth-quarter 2013. Colombia's index remained flat in the first quarter with a score of 93.
In the Middle East/Africa, the United Arab Emirates (114) and Saudi Arabia (102) reported the highest consumer confidence scores in the region, increasing four and one index points, respectively, compared to fourth-quarter 2013. Confidence in Egypt increased most regionally, rising 11 index points in the first quarter to an index of 87. Pakistan increased two index points to 99, and South Africa posted the only regional confidence decline of four index points to 82.
Confidence Is Measured in Sub-Saharan Africa
New to the Nielsen consumer confidence measurement in the first quarter is the addition of three sub-Saharan African markets—Nigeria, Kenya and Ghana.[2]
Consumer confidence was highest in Nigeria in the first quarter with an index of 120. Kenya reported an above-the-baseline index score of 110, and Ghana's index score was just below the baseline at 97. More than half of respondents in Kenya (57%) and Nigeria (52%) were optimistic about local job prospects in the next were 12 months, compared with 42 percent in Ghana.
While 80 percent of Nigerian respondents were confident about their personal finances, just under half (49%) believed that now was a good time to spend. In Kenya, 69 percent of respondents believed money matters were good or excellent, and 36 percent were confident in their current spending capacity. In Ghana, 62 percent were optimistic about their finances, and 34 percent of respondents were ready to spend.
About the Nielsen Global Survey
The Nielsen Global Survey of Consumer Confidence and Spending Intentions was conducted Feb. 17 – March 7, 2014, and polled more than 30,000 online consumers in 60 countries throughout Asia-Pacific, Europe, Latin America, the Middle East, Africa and North America. The sample has quotas based on age and sex for each country based on its Internet users, is weighted to be representative of Internet consumers and has a maximum margin of error of ±0.6%. This Nielsen survey is based on the behavior of respondents with online access only. Internet penetration rates vary by country. Nielsen uses a minimum reporting standard of 60-percent Internet penetration or 10M online population for survey inclusion. The China Consumer Confidence Index is compiled from a separate mixed methodology survey among 3,500 respondents in China. The Nielsen Global Survey, which includes the Global Consumer Confidence Index, was established in 2005.
About Nielsen
Nielsen Holdings N.V. (NYSE: NLSN) is a global information and measurement company with leading market positions in marketing and consumer information, television and other media measurement, online intelligence and mobile measurement. Nielsen has a presence in approximately 100 countries, with headquarters in New York, USA, and Diemen, the Netherlands. For more information, visit www.nielsen.com.
# # #
[1] While an online survey methodology allows for tremendous scale and global reach, it provides a perspective on the habits of existing Internet users, not total populations. In developing markets where online penetration has not reached majority potential, audiences may be younger and more affluent than the general population of that country. Additionally, survey responses are based on claimed behavior, rather than actual metered data.
[2] A mobile survey methodology was deployed to gauge sentiment in these countries, which differs from the online methodology used to report consumer confidence and spending intentions for the other 60 countries outlined in this report. As such, these three sub-Saharan African markets are not included in the global or Middle East/Africa averages.

subset: commoncrawl


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Growing Weed to Become Just as Corporate as Everything Else
In a bid to reassert itself as the dominant force in American life, Capitalism today announced that it plans to immediately counteract the coolness of the legalization of medical marijuana by poisoning it with the awfulness of factory farming.
"Hippies and other anticapitalist types had been acting pretty happy about the slow but inevitable decriminalization of marijuana," Capitalism said. "As weed entered the legal world, I saw a great opportunity to snatch some revenue from growers who've been operating in the black market for decades."
Capitalism's tool in its nefarious and unstoppable plan is California businessman Jay Wilcox, who is taking advantage of Oakland's liberalization of marijuana laws to fuck every longtime hippie grower right in the ass. According to the LAT:
Jeff Wilcox, who owned a successful construction firm and has already incorporated as AgraMed, hopes to convert his empty industrial buildings near Interstate 880 into an enormous production facility. He plans to manufacture growing equipment, bake marijuana edibles in a 10,000-square-foot kitchen and use two football fields of space to grow about 58 pounds of marijuana every day, many times the amount now sold in Oakland.
"Fifty eight pounds of chronic per day, totally legal, totally corporate, in my own fully-controlled factory," mused Capitalism, lighting up a machine-rolled joint with a golden Zippo. "Try to undersell that with your ten hydro plants from your closet, hippie. You'll be out of business in a month. This is the fucking Wal-Mart of weed. It'll be beautiful."
"We have guns, too," the economic system added.


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Mexican Eats: Taqueria La Paz Takes Over Beloved Xochimilco in Sunset Park
When Taqueria Xochimilco slipped away a month or so ago, I was crestfallen. Xochimilco was a great restaurant, often in the shadows of Sunset Park's Tacos Matamoros which lies directly across the street. Nevertheless, it was on most people's radar for their tacos de canasta (delicate folds cradling chile-spiked potato or luscious chicharron), and their pambazos (chorizo and potato sandwiches, French-dipped into orange chili sauce instead of beef jus. These dishes revealed the dexterity of the kitchen and the roots of the owner, who is from the country's capital, Mexico City. Since, D.F.-style cuisine is largely underrepresented in our cities' diaspora, the loss was a sharp sting.
Taqueria la Paz has opened in its place, with new owners, a different menu, and a cheery awning featuring a hard-shell taco wearing a mustache and sombrero. They sell agua frescas on the street outside. The menu is smaller and now anchored by breakfast: bagels with butter, pancakes, and spinach and mushroom omelets. Chilaquiles, tacos, salads, and tortas round out the menu, with a handwritten list of larger plates.
The picadita($2.50), hand-molded corn patties the size of a coaster, was crunchy, though soggy within, like a blackened pancake with still gooey insides. And the gordita($2.50), crisp and pleasantly greasy, stuffed with lettuce, a slice of avocado, and braised chicken tinga didn't register a blip on the palate. The free basket of chips come with a benign pico de gallo. Ask for the salsa roja or verde, instead.
Taqueria La Paz
4501 5th Avenue, Brooklyn NY 11220 (map) 718-435-7600
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.


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BrasswareDesigner bathrooms without the high price tag. Britton bathrooms provide you with a selection of modern bathroom suites that are highly saleable. The styles on offer will suit the tastes of a wide range of your customers and cater for the increasingly popular wall hung trend as well as close coupled style. WCs come with nano-glaze coating making cleaning easier. Cisterns can be adjusted to 4.5/2.5 litre.
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|Institution Type:
|Private not-for-profit
|Campus Setting:
|New England Rural area, remote from an urban area
|Highest Degree Offered:
|Master's degree
|Level of Institution:
|Four or more years
Unity College is perfect for those who love the outdoors, who seek adventure, and who love everything science and nature have to offer. Even if you aren't outdoorsy (like myself)…
If I had to rate Unity College and it was out of 10, I would give it a 10 because I love the small-based community that Unity has for students.…
Unity is a great environmental college. Courses are hands on and there are many activities that students can be active with. Overall, there is a relaxed atmosphere with a little…
Unity College is an amazing environmental school that is committed to involving students in their surroundings and their community. This school offers unique programs that no other school can offer,…
A place for environmentalists. Learn from the experts in your field. Unity is known in the fields it turns out students in as a great place to find employees.…
Unity College is a small, private college in rural Maine that provides dedicated, engaged students with a liberal arts education that emphasizes the environment and natural resources. Unity College graduates are prepared to be environmental stewards, effective leaders, and responsible citizens through active learning experiences within a supportive community.
Unity has tons of opportunities for fun! Day and overnight trips, lots of clubs, intramural sports teams, activities in the res. halls, and lots more. I also already know a few people there and so I know that it is a community of great people.Read More
When I visited, I loved it from the instant I drove into Maine. I went in March, so there was still snow on the ground and I had to wear a snow jacket, but it was worth it. Unity College really cares about you as an individual and realizes that not everyone will go home for the weekend, so there is plenty to do here. With over fifty clubs and intramural sports to choose from, there will never be an instant where you'll be bored. And with the snow, snowman contests and snowball fights are always in effect! :)Read More
I love it here. Most of the classes are outside at some point, there is ALWAYS something to do on a Friday night, and It's small, so everyone knows everyone.Read More
Unity is a very welcoming community and is accepting of people's differences. It has become a second family and a huge influence on my train of thought. I am more appreciative of the people in my life, and the beauty of nature.Read More


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Hi Velouria, this was the dilemma I faced when buying a saddle for my mixte last year. I eventually when with the B66S and have no regrets. The springs provide a far nicer ride than a standard saddle. I do find I move around on it a fair bit though and even now am still tinkering to find the 'perfect' setup for the saddle in terms of angle and where it sits on the seatpost.ReplyDelete
Yes very helpful!ReplyDelete
I just contacted Bryan at Royal H and he is going to make a custom bike for me. I will still want to be seated upright but am looking for something a bit more "sporty" than my Workcycles. I am certain he will be up to the task. I have learned quite a lot from you by reading this blog. It is amazing that you know so much about bicycles and yet you only began riding in the Spring of '08. You are a quick learner! You have really awakened an old love of bicycles in me. I am very excited about the Royal H. Any thoughts about stainless steel frames?
- AnonymousNovember 9, 2010 at 5:53 PM
Thanks for posting this. I've been going back and forth on getting a Brooks and then on which one to get.ReplyDelete
Thanks for the info. I am in the market for a Brooks saddle, but have not decide which to purchase. Your experience with each saddle is invaluable towards my final decision.ReplyDelete
Funny...the Brooks saddles here are a newish B-67s on a 1960 Hercules sports, and a vintage B-72 from 1980 mounted on a DL-1 Tourist of that same year.ReplyDelete
I give the edge for cushion to the B-67s too, but the B-72 is so wonderfully broken in that it's nearly a wash between the two. Different seat rail mounts prevent us from doing a swap and comparing; the Hercules has a modern alloy post as the original chrome one was far too short for proper extension.
Herself finds that even with the pebbled finish on the B-67s, it's still rather slippery, due to still being somewhat new. About how long did you find it took for the saddle to wear in?
It has been properly treated with proof-hide and kneaded in.
Corey K
As far as angle goes, I like to tilt the noses on my upright saddles up quite a bit, or else I slide forward. The angle looks a little scary when the bicycle is in profile, but it feels great while cycling.ReplyDelete
JimP - Oh wow, how exciting to hear that! Stainless steel frames are gorgeous, perhaps a little too much so for me. But if you are brave enough I think they are a great idea. I will be jealous of your bicycle, looking forward to seeing the finished result!
Corey K - "seat sandwich". That is how I have my B72 mounted on modern seat posts.
Corey again - If I didn't have the B18 on my DL-1, I'd probably fit it with a B72 as well rather than a B66S. I don't really have a good explanation as to why; it's just a subjective feeling of appropriateness. Despite its slack seat tube, the DL-1 is actually a much "sportier" bicycle than either the Gazelle or the Pashley, so perhaps that is the reason.ReplyDelete
My 1970 DL1 still has the originl B-72 saddle on it and it is comfortable enough on smooth paved roads.ReplyDelete
I often find myself on unpaved roads and other semi-rough terrain where the B-72 can be a bit of a brutal ride.
The B-135 has my caught my attention. I know it looks excessively sprung, but I like the vintage aesthetic and a cushy ride is what I am looking for.
My only issue in replacing the B-72 is that a new shiny saddle won't have the patina to match the DL1.
- NorthernMikeNovember 9, 2010 at 8:09 PM
I have a B72 mounted on my Pashley Roadster - without a "seat sandwich" - and now that I know what they actually are and what they do - I will be replacing my seatpost with a micro-adjust ASAP.ReplyDelete
The splines that locate the angle of the B72 are in what feel like 6 degree increments - a HUGE difference, for my anatomy, from one position to the other.
Other than this small inconvenience, I LOVE this saddle on this bike.
For the record, I'm also using a Nitto Technomic 40mm length stem and 54cm Albatross bars. These bits transform the Roadster, I don't know why they're not standard equipment...
Thanks for the info!
So here's a weird problem, possibly related to the B67s on both my city bikes: any mid-length coat will hook over the seat while I'm riding and cause me to get stuck when it's time to stop - when I jump off the seat, I literally get hung up on it and can't put my feet on the ground! It's scary and has caused a couple of near crashes. Anyone else have this problem and know if it's specific to the saddle?ReplyDelete
So far I've solved it with a coat that I can unzip a little from the bottom, essentially turning it into a short coat while I ride (also the world's most perfect bike coat in other ways - the Patagonia Tres Parka, I have no connection with Patagonia, just really in love with the way it solves so many problems of riding to work).
I have a B66s on my Hercules, and LOVE it. It's the most comfortable thing ever. But I had an older B72 on my mixte, and it was the most painful thing for me! I tried eveyr possible angle and still could not make it work for me. Maybe it was due to it being a second hand (or third or fourth, who knows) saddle? I replaced it with a B68s, and am much happier. It as the same top as the B66s, but without the springs.ReplyDelete
Forrest Lee Causseaux - If you want a heavier sprung saddle, there is also the B33. The Co-Habitant has it on his Pashley and loves it. He is around 200lbs and it both supports him and cushions.ReplyDelete
Nina - Not that I am "glad" you are having this problem, but I am relieved that I am not the only one. The same thing happens to me with pea-coats that have a slit up the back and with very short skirts or very long tunics. I think it's dangerous and I was especially freaked out by the saddle catching things when I first started cycling. But no matter who I spoke to about this, no other women seemed to be having this problem and I felt that I must be a special sort of klutz to be experiencing it. The only way I've been able to solve this, was to not wear clothes that cause this problem. I get off my loop-frame bikes by jumping off to the side, and if my coat were to get caught on the saddle it would be a disaster.
Amy - the older saddles can be either very comfortable or very uncomfortable... depending on how similar your (pardon) "butt imprint" is to the previous owner : )
Nina - I've had that problem too! It's happened to me with both coats and skirts. The other semi-related problem that I've had is that whenever I wear pants that have back pockets, the pocket always gets caught on the nose of the saddle whenever I hop up on it.ReplyDelete
Velouria - I had figured that is was something along the lines of dissimilar "butt imprints" :) I would be curious to try out a new B72 to see how different it is to my former one.
When you were building up the Royal H., you asked for advice about which saddle to put on it. What made you decide to go with the B72 over, say, a Flyer or B17? (I ask this as I consider components for my own mixte build.)ReplyDelete
This is actually my first comment to your site, although I've been reading faithfully since I discovered it a few months ago. Thanks so much for your wonderful, thought-provoking posts. I've learned so much about bikes from your blog!
I've got an old B66 on the DL-1. Its in nice shape and I like it very much for the purpose, i.e. relatively short rides of typically less than 10 or 12 miles around town. Great saddle.ReplyDelete
Would love to put a B17 Special on one of my road bikes and ride the full length of Paris Roubaix.
Forrest, the B135 goes beyond the vintage aesthetic into possible steam punk territory. Which is not a bad thing IMO. And if it takes a big man to cry, I would say it takes an even bigger man to bottom out the springs on a B135.
Cara - I tried the mixte with the B17 and it felt too narrow. The same was true with the Flyer on my vintage mixte last year, but I wasn't experienced enough to realise it at the time and didn't know why my saddle kept hurting me after months of riding that bike. Also, while at first I thought the springs on the Flyer were fine, I changed my mind when I began cycling faster and more aggressively - the springs would toss me up in the air over bumps and pot holes!ReplyDelete
After trying the Royal H with the B17 (on some short rides and then on a 40 mile ride) and not liking it, I next tried the B68. It felt much more comfortable than the B17, but "weird"; just didn't seem to feel right with the bike. So finally I tried a B72 and within the first 5 minutes I knew it was "it". I simply forgot all about the saddle as soon as I started cycling, and that's what made it clear that it was the perfect fit. Thankfully I was able to return the B68, and the B17 was borrowed from one of my roadbikes, so no money lost. But I am still regretting buying that Flyer for my vintage mixte last year!
forrest lee: there's also a heavier sprung saddle that's not as wide as the B33, which is *huge*. it's the B73, and it has the same size leather top as the B72, except that it has triple coil springs, two in back and one in front. my wife has it on her dutch bike:ReplyDelete
JimP - Henry Cutler (WorkCycles) had a short discussion with "Feddo" about a stainless steel version of his Fr8 some time ago. Read here:ReplyDelete
It seems titanium would be preferable, and even more expensive.
Amy - funny, I do have the pocket problem too. Haven't really solved that one yet except to do a slightly embarrassing scoop dance to get back on the seat. :)ReplyDelete
I have a 30 year old Brooks B72 saddle on my Raleigh Sports (the original saddle from 1968) and I love it. It's extremely comfortable! I got a chance to sit on a newer Brooks saddle for the first time this past weekend while using Dottie's Betty Foy. I was so excited to see that my 30 year old Brooks feels just as great as a newer model. That's quality and durability!ReplyDelete
My 78 Raleigh Grand Prix also has the original Brooks saddle on it and from what I can tell it's what they call a 'racing saddle' and may be an L15. It's vinyl and padded. I also find it extremely comfortable.
On my commuter I ride Velo Orange "Milan" handlebars and the Gyes/Velo Orange "Parkside" saddle, which is similar to the Brooks B67--which is a B66 with a double-rail rather than a four-rail undercarriage. (This means that the B67 can be used as-is on modern seatposts with built-in clamps, while the B-66 or B-72 requires the use of an adapter or to be used on an old-fashioned plain-tube seatpost.) I've ridden the B67 and B72, as well as the Ideale 6, which was similar to the Brooks B72.ReplyDelete
What I'd really like for commuting is a saddle with the B-72s "loop" rails, as I don't feel I need the springiness of the B66/67 or Parkside. I'd also like for it to have two rather than four rails, and for the top to have the same width as the B66/67 or Parkside. I'd also like for it to have the length of a men's saddle, but to have the down-turned front of the Brooks B-18 "Lady" saddle so I could wear skirts easily, altough the rails and width are more important. (I can ride a saddle while wearing a skirt.) And I'd like for it to have the kind of saddle bag loops found on the B17.
For now, I'm riding the Parkside, as I got it cheaply and the bike (from which I had a saddle stolen) spends lots of time parked on the streets. As it's not used for long rides, I find the seat's cushiness tolerable.
Amy, Nina and Velouria: I have had the same problem when riding in skirts or longish coats. By the way, it's not just a "girl thing": Back when I was the "before" photo, I sometimes rode to work in a jacket that caught onto the nose of the saddle. And I've had the back pockets of pants do the same thing.ReplyDelete
I like your solution, Nina. I might take a coat to a tailor and have a zipper sewn into the rear. (I still can't sew worth a damn!) You might also want to try the Brooks B18 "Lady" saddle, which has a nose piece that curls down. I had one but sold it because it's wider than I like.Replies
- AnonymousAugust 15, 2013 at 2:53 PM
I know this is years too late, but don't put a zipper in the back of your coat where it will scuff both you and your beloved saddle. Have a vent pleat put in, lined with some attractive fabric, and you will not have the problem of either catching yourself on the saddle or gouging everything with a zipper.Delete
As an afterthought, I took another look at the 1980 B-72 on my roadster a few minutes ago, and it is pebble-textured on top, with rounded edges. Hmmmm.ReplyDelete
That would explain your reticence to discuss the vintage ones, Velouria!
I too occasionally catch my back pocket on a saddle, but never on one of the Brooks models.
Titanium is not an option. Odd that in the discussion SS is supposed to Increase the weight of the bike. Not what I have read at all:
and here:ReplyDelete
I also have that long tunic and short skirt problem with the saddle on my Retrovelo, which is B67s. It is a drag and also rather more attention getting than is desirable, since I generally have to hike up my skirt to unhook it. I haven't had any near crashes with it, but it does makes me feel like an idiot and blush. It doesn't happen with swingier clothes but does with pencil minis and a-lines.ReplyDelete
Velouria - I did see a B33 on eBay that was solid black, seat, frame, and springs. Unfortunately I missed that auction but in doing so I decided to look at the Brooks website and found the B135. It brings fond memories of my old 1897 Crescent which had a very similar double action seat. (may its Victorian soul rest in peace – incinerated in a house fire – nothing burns quite like hundred year old wooden rims!).ReplyDelete
I haven't an issue with a saddle carrying weight. I am just a touch over six feet but weigh only 170-5 depending on the amount of pizza just eaten.
I have my mouth set for a B135 at this point…and now a pizza.
I had not thought about my long coat and coil springs. Hopefully my saddle bag will solve that possible issue.
Bif - Indeed the B135 does touch on the Steampunk aesthetic. I had not thought of it that way, but I give it a plus for that as well!
somervillain - Yes, I saw the B73 and wondered about the stability. With three coil springs does it increase the amount of sway? Absolutely gorgeous bicycle too!
Here is my pride and joy: http://www.flickr.com/photos/11656570@N07/4999636498/
Sorry Velouria, I kept a picture of Co-Habitant's DL1 next to mine for a few days to decide on cream tires and just could not tear myself away from my old black ones.
forest lee: your raleigh is a beauty!ReplyDelete
as for the B73, i've never really felt any lateral play. i suppose if you were racing, or a lot heavier (i'm 6' and 165 lb), i might feel some lateral movement, but for the few times i've ridden my wife's bike, i've enjoyed the saddle. it's definitely cushier than a B67 (which I have on my DL1), despite having almost the same footprint (or should i say "buttprint").
- AnonymousNovember 11, 2010 at 7:19 AM
Like many other commenters, I'm so grateful for these comparisons. I sort of like the B17 on my single speed Abici, because its narrowness and lack of suspension gives an incentive to lift myself out of the saddle and pedal more energetically at least part of the time (using the saddle to balance with more than sit on). That's good practice and a nice change, as it's impossible for me on the Pashley and feels unnecessary on the wildly comfortable Betty. But the B17 is very hard and narrow compared with the cushy B66/67. So far I haven't ridden for more than an hour on the Abici, and wouldn't want to unless I change to a springy, wider saddle. Does the B72 squeak less than the B66/67? I wondered if Abici etc go for the unsprung saddle for the sleek elegance and simplicity not only in looks but in sound.ReplyDelete
By the way, I was pondering the whole unicrown fork thing on the Abici granturismo, and decided that I actively like it! I don't mean that I'd want to see it on other lugged bikes, but I think the smooth lines suit the simplicity and curviness of the bike. So I wonder if it was an aesthetic decision for them as much as or more than a budget one. I do agree with what many were saying about the cranks, though. And I have mixed feelings about the coaster brake, which I'm being very slow to get the hang of, so (for now) am just using the Abici on bike paths, not in traffic.
Hello, I have not posted on this site before. I have a B67 on my made to measure touring cycle. I put a spirit level on the saddle to get it level. My saddle is a pre-aged one. I also applied Neatsfoot oil underneath where my 'sit-bones' rest. After my last 45 mile ride I now have two nice dimples in my saddleReplyDelete
- AnonymousNovember 14, 2010 at 10:30 AM
It might just be me but Brooks saddles look incredibly hard and potentially painful; haven't (I don't think) tried one.ReplyDelete
- AnonymousJanuary 27, 2011 at 12:34 PM
I love Brooks B67s but the price keeps escalating even though the exchange rate hasn't. I've found that the Gyes Parkside is a pretty good substitute and very close in quality to Brooks. It seems to take a bit longer to break in. I bought one in very light Natural Tan for about $65 and it looks beautiful. Gyes also makes the saddles for Velo Orange.ReplyDelete
I just picked up a used and pebbled B72 for $30, including a tin of proof.ReplyDelete
haven't mounted it yet.
Thanks for the review/opinion.
I'm cycling to and from work as often as possible, an hour each way on a Gazelle Basic. This has the Selle Royal which does lead to a bit of saddle-soreness. Would it be worth upgrading to a Brooks? Or just wait for some callouses to develop? The £70 or so needed is a bit on the expensive side for me...ReplyDelete
- AnonymousJune 29, 2012 at 12:25 PM
This is a good post, realise its pretty old, but as good a place as any to provide some quasi-evangelical feedback on Brooks saddles. 12 years usage distilled below. If you've never experienced discomfort while cycling youReplyDelete
probably don't need one - otherwise please read on.
The Dutch Gazelle
12 years ago, when living in Amsterdam (those were the days...), I picked up a 'tweedehands' Gazelle touring bicycle. The bike was immaculate but the seller had fitted a clapped out Brooks B66 saddle. My first thought was to throw it away but after riding it for the next few weeks I was overcome with enlightenment...
The Brooks saddle
I've always cycled as a form of transport (and weekend rambles to nice places with stops at the pub to refuel). However I'd never been comfortable with rides of more than about 1 hour in the saddle (I'd get pain down my right leg). To help I'd tried various saddles (wide/narrow/sprung/ergo?) and various bikes (the low point was a bike with rear suspension). But nothing helped. With this old, clapped-out, slightly-saggy and generally past-it's-sell-by-date saddle I found I could ride longer distances for the first time in my life without pain! This was such a revelation I found out everything I could about Brooks saddles then splashed out on a fully-sprung double-rail B67. I've had the B67 for 12 years now - as strong as new - this has enabled me to start cycling 'normally' culminating in a two week, 50 mile a day tour through Northern France (Normandy/Brittany) with a cycling buddy.
The (my) Medical opinion
The Brooks has moulded to the shape of my arse (or 'sit bones'). From this I have a clear visual picture of where my previous cycling problems had come from. There is a visibly deeper indentation on the right side of the saddle and also the saddle has 'twisted' down on the right side by about 0.5 cm. From this I can see that my 'sit-bones' are not symmetrical
and the saddle has moulded to my shape. This has answered many questions regarding on-going niggling back pain I've had over the years (i.e. sitting down for long periods on office chairs with unsymmetrical sit-bones). Now on the bike I feel totally connected and can ride all day (if I had the time to do this anymore...). By the way, I'm relatively normal in ther respects, tall, slim with both legs the same length etc.
The B66 vs. B67
My preferred riding position is handlebars equal/slightly lower (never higher) than saddle with weight evenly balanced 50/50 between saddle and handlebars (a kind of 'balanced arch' where I can still see what's around me and 'smell the flowers' as I cruise along i.e. Not head-down grinding and not sit-up-read-the-newspaper, or at least this is how I visualise it...). I found the B66 a little too wide and more suited to higher handlebar position. The B67 is slightly
narrower and works perfectly or me. If I was to buy another I'd get the B67 single-rail which is compatible with micro adjust seatposts. (but would it be as bombproof?) Maintenance wise you don't need to look after these much other than the occasional application of 'proofride'.
I now have one bike (Gazelle) and one saddle (Brooks) and after all the years of effort to get here I see no reason to change either!
- AnonymousJuly 18, 2012 at 2:44 PM
I had a B72 on a Raleigh Sport and it was torture, bruising the end of my spine...until I raised the seat and gave myself the leg length that improved my entire ride. Comfort is not always seated where you assume it is. Pardon the puns.ReplyDelete
- WGulliverOctober 24, 2012 at 1:54 AM
Thank you for your comparison! I am building a bike for a friend of mine and we have been going back and forth about this. Now we can make a much more informed decision.ReplyDelete


text: Just curious of you lucky ones that went to SNF and survived. Did you notice which temporary tiedowns worked and more important which didn't. I made up a set which I carry all the time in the cargo compartment which is 3 - 6" round 1/8" plates with an eyebolt in the middle and 3 holes which I drive 10" nails thru at an angle. I have never actually tested to see how hard it is to pull them out but now I'm thinking it is more important than I thought. I know a picture would be nice but like I said they are in the plane.


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The Speaker of the House of Representatives of the 54th Legislature Bhofal Chambers has suggested that the country should move towards a single currency regime, blaming the two currencies for "disastrous growth levels and stubbornly high and bad economy."
Dr. Chambers is recommending the removal of the Liberian dollar and the adaptation of the United States dollar as Liberia's "single currency."
He informed journalists on Friday in his Capitol Building office on Capitol Hill, in Monrovia, of why he prefers the "permissibility of the US dollar to be the single currency regime for the Liberian commerce and trade amid the excruciating challenges the economy is faced with."
Chambers said monetary control in the Liberian economy is seriously challenged by the lose availability of the two Liberian currencies in multiple styles and values of denominations.
He bitterly accused former President Ellen Johnson-Sirleaf during the end of her tenure of creating "an economic gulag," which is related to a soviet style economic and militarily fashioned scenario that compel compliance on economic activities.
According to research, the word "Gulag" is an acronym for the Main Administration of Corrective Labor Camps and Colonies that the Soviet prison system started as a means of isolating "counter-revolutionary elements." But with the beginning of the Five Year Plan it became a form of economic colonization…
But Chambers said President Sirleaf Administration printed the Liberian dollar in huge quantities, which have now flooded the economy and are chasing the few United States dollars coming into the country's commerce and trade corridors.
He said members of the 53rd Legislature and other economic partners warned the President at the time not to print new bank notes, "but she did not listen, thus contributing seriously to the present condition of the Liberia's economic woes."
Another indicator the Speaker proffered is the low security features on the new banknotes printed by Ellen's regime, which have given rise to the "wanton counterfeiting of the Liberian dollar by unscrupulous individuals."
Dr. Chambers, however, said he is cognizant of Liberia's balance of trade deficit, but said the country's exports and imports imbalances cannot be singularly responsible for the current economic debacle.
"It would be expedient if this government withdraw the multiple local currencies from circulation, adapts the United States dollars and subsequently introduce a highly sophisticated and secured feature prone currency," Speaker Chambers said.
"Until some radical decisions are made to curb the economic situation in the country, like adapting a single currency, the woes may deepen," he added.
He however assured Liberians that the economic issues the country is faced with will be overcome by the Weah Administration as government is now finding a lasting solution to the situation.
"The state of the country is strong and secured, and I wish the Liberian people a happy and memorable observance of the 171st Independence Day come July 26," he said.
It can be recalled that as part of propositions to amend the Constitution with the adaptation of US dollar as a single currency, the Liberia Business Association (LIBA) rejected the proposition for the eradication of dual currency in Liberia, arguing that the country does not have the productive capacity to institute a single currency regime.
LIBA said the international financial system would not have confidence in the country's single currency, owing to the country's low economic output, coming from conflict and being characterized by mismanagement of its economy over the decades.
The then secretary general of LIBA, Ms. Leelai M. Kpukuyou, recently gave her expert opinion to lawmakers in Ganta, Nimba County, during a five-day retreat on the Proposed Amendments to the 1986 Constitution of Liberia.
Ms. Kpukuyou said though timing is important, LIBA believes that the House of Representatives should delay moving toward a single currency in the immediate future until productive capacities are greatly improved.
"Until we add value to our own currency through Liberian businesses, we cannot have a single currency," Ms. Kpukuyou said. "We need to take our economy from the hands of foreigners, formalize the informal business sector, then we are ready for a single currency," she noted.
She pointed out that recent statistics from the Central Bank of Liberia (CBL) indicate that more than 70 percent of broad money (M1 and M2) is denominated in US dollars.
"Accordingly, the use of the dual currency regime has been a blessing for Liberia's economic recovery," Ms. Kpukuyou said.
"While Liberia has officially sanctioned the use of the United States dollar as legal tender, it is not the only country in the world with high dollarization. Other countries, such as Ecuador, El Salvador, Panama and Eastern Timor have higher proportions of foreign currency deposits to broad money," she recalled.
The strength of any country's currency depends on productivity for local consumption and for export, which will allow the country to maintain a considerable balance, according to Kpukuyou.
Liberian Dollar
In August 2017, the House of Representatives passed a law ensuring that all monetary transactions in the country are done in Liberian dollar. This means all transactions, including purchases, sales and related business deals in the country will be done by use of the country's local currency.
Liberia is currently a dual currency country, with the US dollar being secondary. But the US dollar has dominated the market, being the most demanded currency for purchases and payments, even at government entities.


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Search for Cerro Gordo County, IA civil services. A civil service search provides information on civil service jobs, government jobs, public employees, government human resources, government job centers, government recruitment services, filing a retaliation complaint, filing a discrimination complaint, government job services, resume assistance, government recruiters, and job applications.
A Human Resources Department is responsible for attracting and retaining quality employees, and they operate both as government departments and in private companies in Cerro Gordo County, Iowa. At the Cerro Gordo County government level, they coordinate the recruitment process to fill open positions, create and update job descriptions, and post job announcements internally and externally. Cerro Gordo County Human Resources also review submitted application materials and make arrangements for interviewing candidates. Human Resources Offices in Iowa provide online access to their job postings.
Mason City Human Resources Mason IA 10 1st Street Northwest 50401 641-421-3378
An Unemployment Office provides support for unemployed workers, including both public and private employees in Cerro Gordo County, Iowa. Cerro Gordo County Unemployment Offices provide financial assistance in the form of unemployment insurance, and they can help qualifying workers apply for weekly or monthly payments. They also provide employment services, including online job centers, resume assistance, and employment workshops. Unemployment Offices in Iowa provide access to recruitment services for public jobs. For more information on civil services at an Unemployment Office, visit their website.
Mason City Unemployment Office Mason IA 600 South Pierce Avenue 50401 641-422-1524


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Subsea Mining & Mineral Extraction
ContiTech Oil & Gas is leading the way in the development of innovative systems for these most challenging operations.


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Liz Eeuwes is a Canadian designer based in Glasgow, Scotland. Since graduating with a degree in Product Design from the Glasgow School of Art, Liz has set up a home studio in order to develop her own designs.
Her first collection is a range of artistic, textured rugs inspired initially by the rich colours and diverse structures of the Scottish countryside. Recognising the similar visual effects of rugs and aerial views of landscapes, Elizabeth began experimenting with various pile heights, hand knotting, weaving, colouring and carving techniques in order to accurately capture the look and feel of these areas.
Each rug is made entirely by hand using the finest materials and the result is a collection of high quality unique pieces that combine colour, texture and shape in a new and exciting way and are appropriate for both contemporary and traditional environments.
Liz Eeuwes' carpets will be exhibited from 24 – 27 Septmember at 100%Design London, Earls Court.


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Find Our Latest Video Reviews on YouTube!
If you want to stay on top of all of our video reviews of the latest tech, be sure to check out and subscribe to the Gear Live YouTube channel, hosted by Andru Edwards! It's free!
Thursday February 28, 2008 12:42 pm
Runner Hub is Functional, Stylish
Posted by Sheila Franklin Categories: Accessories, USB, Design, Misc. Tech
For someone who is always on the go (or on the run,) the Runner Hub may be your answer. The 4 ports hub will work with either 1.1 or 2.0 USB, has a transfer speed of 480 Mbps, and will work with either Windows 98/ME/2000/XP, or Mac OS 8.6 or above. At a size of 100 x 60 x 123mm and a weight of 71g, the device, with its rotating connection, comes with its own USB cable. Find it at Brando for a mere $12.00.
(Thanks, Fanny)
Read More | Brando
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Maa Television Network has launched an Telugu music and lifestyle channel called Maa Music today, which the company claims to be the trendiest and contemporary.
The programming mix is like a full platter catering to the musical taste of all kinds of viewers, which includes back to back music, live shows, interactive, and fillers. Apart from music, the channel also focuses on lifestyle shows.
Sharrath Marar, CEO, Maa Television Network, said, "Maa Music stands as an extension to the vibrancy and youthfulness of the main channel Maa TV. We aim to make it the most entertaining and comprehensive music and lifestyle channel in South India." says
Tags: maa tv


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- This event has passed.
Playing is Learning
January 31 @ 10:00 am - 12:00 pm EST
For ages 0-5. Join us at the library for a morning of self-directed play! Play is one of the best ways for children to learn language and early literacy skills. Children will make new friends and have fun at their own paces. Call 336-229-3588 for more information.


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4126, "Cannot delete image. It may be mounted or used by another application." - one space too much between used and by.
4146, "Phisical Device" - Physical
Sometimes it is "sub-channel", sometimes "subchannel". I think this should be equal.
4023, "Stop virtual SCSI adapter"
4043, "SCSI Adapter"
4045, "Start SCSI Adapter"
4046, "Stop SCSI Adapter"
4051, "Start IDE Adapter"
4052, "Stop IDE Adapter"
4306, "Starting IDE adapter"
4307, "Stopping IDE adapter"
Same here with adapter.
5253, "Add SCSI Virtual Drive"
5254, "Add IDE Virtual Drive"
Shouldn't it be "Add SCSI virtual drive"?


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Season dates and updated regulations are out. See the DEC website for details.
A PDF of the regulations is available here.
Don't forget, in addition to your regular hunting license, you also need to register with HIP and have a federal duck stamp to hunt waterfowl. Registering with HIP is free. A federal duck stamp is $15 and is available at most post offices.


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A native of San Antonio, Flores moved to San Diego with her family when she was 12. Her family encouraged her singing and guitar playing, and as a girl she soaked up the sounds of southern California -- surf guitar, country and country-rock, blues, and rockabilly-flavored garage rock. By the time she was in her teens, Flores was playing in a band called Penelope's Children. During the first explosion of punk rock in the late '70s Flores formed Rosie the Screamers, an otherwise all-male band that played hard country and rockabilly material, much of it written by Flores herself. She worked as a solo acoustic artist for a time but then formed an all-female punk band, the Screaming Sirens, who recorded the album Fiesta in 1984.
In 1987 Flores recorded her first solo album, Rosie Flores, produced by Pete Anderson (Dwight Yoakam's producer and guitarist) and released by Warner Bros.. The album gained critical acclaim, and among music-industry folk a Flores concert remains a strong draw to this day. But it was only modestly successful commercially, and Flores was dropped by Warner Bros.. She signed with the California independent label Hightone and in 1992 she released her second solo album, After the Farm, followed by Once More with Feeling a year later. These albums featured original songs by Flores, her own sharp guitar leads, and crackerjack session work from a variety of Los Angeles veterans. Flores then spent the better part of 1994 playing lead guitar in Butch Hancock's band.
In 1995 Flores recorded Rockabilly Filly, a spirited tribute to the music she grew up with. The album featured duets with her longtime idols Wanda Jackson and Janis Martin, both of whom Flores brought out of retirement for the project. The album led to a cross-country tour with Jackson, who hadn't played in nightclubs in over 20 years. In 1997, Rounder re-released her Warner Bros. debut along with six new bonus tracks under the title Honky Tonk Reprise, helping to sustain the momentum of her career. That same year, the Austin label Watermelon released her duet project with Ray Campi, entitled A Little Bit of Heartache. In the late '90s, Flores moved to the folk-oriented Massachusetts label Rounder, pushing the stylistic mix of her music slightly in the direction of rockabilly but not really changing course. The 1999 live album Dance Hall Dreams was recorded at a San Antonio country club and featured several of the top session players Flores has always been able to attract, among them Texas steel guitar stalwart Cyndi Cashdollar. Flores released Speed of Sound on the Eminent label two years later, offering yet more original songs as well as a scorching cover of Buck Owens' rockabilly classic "Hot Dog." Flores offered her fans an intimate perspective on her music with the solo acoustic live set Single Rose in 2004, and an album of country- and rockabilly-styled holiday favorites, Christmasville, followed in 2005.
After a short hiatus, in 2009, Flores celebrated over two decades of recording with Girl of the Century, an album recorded with the Mekons' Jon Langford and the Pine Valley Cosmonauts for Bloodshot Records. Her raucous 11th album, Working Girl's Guitar, which appeared in 2012, was the first in which she handled all the production and guitar leads herself. With 2019's Simple Case of the Blues, Flores put the focus on her love of blues and vintage R&B, covering classic tunes by Wilson Pickett and Roy Brown along with a fresh batch of originals steeped in the classic styles. When not on the road, Flores gigs regularly in Austin, Texas with the Blue Moon Jazz Quartet as well as her more roots-oriented project the Rhythm Rockers. ~ James Manheim, Rovi


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Ladies & Gentlemen!
Introducing to you the biggest, the best, the most
"Give-Aways & Reviews"
Applause – Applause!
Do you want to show them off? Would like to have comments on those REVIEWS? Well, this is the place! Just strut your stuff here!
Have a great day and thanks for coming, but before you leave if you would like to follow me in whatever button you would like to choose feel free. I return all follows if you let me know about it.
*I will enter at least one of the shared give-aways every Tuesday & I will try to do comments at all of the reviews to thank you for taking the time to Post your goodies!
Please follow me in my Linky Followers & my e-mail too if you'd like to know what the hell I'm up to! 🙂 Also, if you have my old buttons please delete them in exchange for my new ones in my side-bar & my e-mail too. Thanks so much!
Go see my bud Danielle at Treasure Hunt Tuesday if you'd like to show off your give-aways again! WOO HOO! She loves company!
By the way you can also find me at my buddy Stacy's! HAVE A GREAT DAY!


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This is compressing, meaning that we have been getting further from the standard in the complacent direction. Can it mean that it will take a proportionately stronger move in equities to get it back into historic ranges? Hmmm… just another clue, and Yves, as usual, is sniffing them out!
The Amazing Shrinking Put/Call Ratio!
by Yves Lamoureux, Macquarie Private Wealth
Have you noticed lately the behaviour of the put/call ratio? Once you read the next few lines, you will agree with us that it is a rare event.
We have tracked this interesting behaviour since 2007. It is a compression event taking place in the ratio. You will notice it from a quick glance at our chart.
The put/call ratio is usually defined between a mathematical range. The best example is provided at the left of the graph. The ratio will bounce around from the mean to +3 standard deviation on a sudden drop of the Dow Jones, taking it to under 13,000.
That would be normal behaviour. In our present circumstances, something very different is happening.
The Dow started a downward trend in 2008. Sentiment is responding in a very different manner this time. With each successive drop, negative sentiment will rise less. The red arrows provide evidence of the high that was reached. From drops in the stock market beginning in early 2008, the P/C would only get to +2 standard deviation. The phenomenon continues as the ratio gets progressively compressed.
Movements in stocks toward the fall of 2008 got to + 1 standard at best.
I find the behaviour of this ratio in 2009 extremely interesting. The market's rally provides further reduction in the swings. The P/C ratio fluctuates in an even more dramatically lower range. You will find the drifting between -2 standard deviation and the mean.
Remember that the recent high in January 2010 reflects a higher level of comfort, circled in purple, than investors felt at the 14,000 peak established in 2007.
The opinions contained in this report are those of the author and are not necessarily those of Macquarie Private Wealth Inc (MPW). Every effort has been made to ensure that the contents of this document have been compiled or derived from sources believed to be reliable and contains information and opinions which are accurate and complete. However, neither the author nor MPW makes any representation or warranty, expressed or implied, in respect thereof, or takes any responsibility for any errors or omissions which may be contained herein or accepts any liability whatsoever for any loss arising from any use of or reliance on this report or its contents. No entity within the Macquarie Group of Companies is registered as a bank or an authorized foreign bank in Canada under the Bank Act, S.C. 1991, c. 46 and no entity within the Macquarie Group of Companies is regulated in Canada as a financial institution, bank holding company or an insurance holding company. Macquarie Bank Limited ABN 46 008 583 542 (MBL) is a company incorporated in Australia and authorized under the Banking Act 1959 (Australia) to conduct banking business in Australia. MBL is not authorized to conduct business in Canada. No entity within the Macquarie Group of Companies other than MBL is an authorized deposit-taking institution for the purposes of the Banking Act 1959 (Australia), and their obligations do not represent deposits or other liabilities of MBL. MBL does not guarantee or otherwise provide assurance in respect of the obligations of any other Macquarie Group company. Macquarie Private Wealth Inc. is a member of Canadian Investor Protection Fund and IIROC.


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Every year, incredible drivers from around the globe gather to face off against one another on a specially made circuit in equally prepared cars. The Race of Champions is the only chance each year to see champions from every discipline compete against each other.
But it has never been seen live in America. Until now.
Our friends at DRIVE have worked tirelessly and now, this weekend, you will be able to watch the RoC exclusively in the USA on Jalopnik and DRIVE.
This year's race is taking place in Bangkok, and will start airing on YouTube at 7 PM EST on Saturday and Sunday. Trans Am Champion/Badass Tommy Kendall, John Hindhaugh from Radio LeMans, and DRIVE's very own Leo Parente will be calling the races, which will feature drivers like Michael Schumacher, Sebastian Vettel, Ryan Hunter-Reay, Mick Doohan, and other international champions.
It's going to be epic, and we'll be presenting the races here for your viewing pleasure both nights. We. Can't. Wait.


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There's World Turtle Day (May 23) and then there's World SEA Turtle Day, which is today! Why is June 16th World Sea Turtle Day? It is the birthday of Dr. Archie Carr who is widely known as "the father of sea turtle biology." Dr. Carr focused his entire career on sea turtle research and conservation. According to The Sea Turtle Conservancy:
Archie Carr was a great biologist. His early descriptive studies of turtles set the standard of quality in the field of natural history. Later on, as he focused on sea turtles, he moved toward ecology and behavior, although his work always retained a taxonomic and evolutionary perspective. For decades the National Science Foundation (and the Sea Turtle Conservancy and the Office of Naval Research) supported his research at Tortuguero, enabling him to mount one of the longest lasting and most intensive studies of an animal population that has ever been done. To date, more than 35,000 adult female green turtles have been tagged at the research station at Tortuguero. From this effort have come papers by Archie Carr, his students, and other investigators on orientation, migration, nesting behavior, nest physiology, sensory physiology, nutrition, demography, and other subjects. Almost all of the studies have significance for conservation — Archie Carr was a conservation biologist long before the field was recognized.
Of the 7 sea turtle species, 6 are listed by the IUCN Red List as either vulnerable, endangered, or critically endangered. They are: leatherbacks (vulnerable), loggerheads (vulnerable), hawksbills (critically endangered), green sea turtles (endangered), Kemp's Ridley (critically endangered), Olive Ridley (vulnerable), and flatback sea turtles (data deficient). What can you do to protect sea turtles?
- At night, keep bright lights off the beach to encourage sea turtles to nest and to ensure hatchlings can find their way to the sea.
- Keep beaches trash free to avoid turtles mistaking it for food or getting caught in plastic loops. Single use plastic bags are often mistaken by sea turtles for their favorite food, jellyfish. Consumption can cause them to suffocate.
- Join a coastal conservation effort working to protect sea turtle nests from predators.
- Of course you can always donate to MarineBio to help us share species information and raise awareness about the plight of endangered sea turtles. Whether you can spare $5 or $50, it will help us continue bringing the world a vast source of information on all things ocean.


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10 Rue Lenoir Parc scientifique Einstein B-1348 Louvain-La-Neuve Belgium
+32 (0)10 39 50 70
GlobalTT is a private internet satellite earth station/teleport, located in Brussels, Belgium. 100% of operation/control is on a same site (antennas, fiber links, broadband platform, security, support team, NOC, sales team, logistics, software & hardware developers, quality control, 24/7 monitoring, management, stock, etc). Service focused only on SOHO/SME, industries, NGO's, local ISP / carriers / operators, Oil & Gas companies, etc.


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Trinity County ARES & California Emergency Communications Groups
The Net is held weekly on Monday night on the N6ICW and K6IS repeater systems. The two systems are linked during the net.
Time: 7:00 PM
N6ICW: 147.195 MHz (+) pl 123.0
K6IS: 145.190 MHz (-) pl 162.2
Event's listed with '+' before are looking for more radio operators. If you have an event to list with us, send an email to email@example.com.
© 2014-2015 Sacramento County ARES. All Rights Reserved.


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FDA Battles Unapproved Contact Lenses
The government is cracking down on decorative contact lenses - from the wild-eyed Halloween look to lenses imprinted with sports logos - that are sold without a prescription, calling them illegal products that could cause blindness.
The Food and Drug Administration began stopping imports of the decorative lenses at U.S. borders Monday, and said it will seize unapproved lenses sold in convenience stores, flea markets and other spots.
The FDA cites dozens of reports of corneal ulcers - abrasions that can rapidly lead to vision-threatening infections - and other eye injuries linked to the products. The agency said that in some cases corneal transplants were required to save eyesight.
Consumers should not wear decorative contact lenses unless they are properly prescribed and fitted by an eye-care professional, the FDA said in a warning issued late Monday.
Decorative lenses have become increasingly popular over the last several Halloweens, but the FDA said its warning wasn't tied just to the upcoming holiday. The agency recently completed an investigation that found widespread illegal sales of decorative lenses along the East Coast - they are surprisingly popular at beach shops, next to the sunscreen - and to a lesser extent elsewhere in the country, said FDA Deputy Commissioner Lester Crawford.
People "get the idea since they're out there that they don't pose the same safety issues" as regular contact lenses, Crawford said. "But these things are risky ... so we're taking action for public health reasons."
The FDA has approved the prescription-only sale of some contact lenses for cosmetic use, such as colored lenses, Crawford said. The FDA's approval guarantees the lenses were made under sterile conditions, and requires that consumers be told how to insert and care for the lenses in a way that minimizes chances of such side effects as infections or abrasions.
The agency has never allowed a contact lens to be sold without a prescription, and has debated for months whether it could legally crack down on decorative ones being sold without any oversight.
"These would be very hard to call medical devices," Crawford acknowledged. "But nonetheless they cannot be on the market without some kind of approval."
The FDA urged consumers who have had problems with decorative contact lenses to notify agency offices in their state or call 1-800-FDA-1088.
By Lauran Neergaard


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I'm Listening: Dr. Moutier on the 'Unintended Consequences' of Social Media
It's time to stop the stigma and promote the positive
On Sunday September 8, all Entercom radio stations across the country marked the start of National Suicide Prevention Week with a special commercial-free broadcast of I'm Listening, a two-hour program dedicated to ending the stigma of talking about mental health.
Along with artists, athletes, and listeners sharing their story, Dr. Christine Moutier from the American Foundation for Suicide Prevention joined the show to talk about the steps being taken to curb the "unintended consequences" of social media.
"We're learning so much about what it means to live out this newfound value on mental health," explains AFSP's Chief Medical Officer. "Certain things like the likes, and some types of social media utilization have really led to worsening in mental health. Young people, advocates who are young people have learned that for themselves there are times that they should unplug and take a break for the sake of their mental health."
Moutier addressed the idea of hiding likes, which Instagram has begun testing in certain areas, and discussed the impact that this curated world can have on people, saying that it leads to a "totally distorted view of what other people's lives are like, when you are having ups and downs and the usual state of good days and bad days."
"Or if you have anxiety or depression, it can really feel even worse and feel like you're the only one and of course that's not true," adds Moutier. "There's a lot of movement and progress being made to try to address some of those unintended consequences that are really serving to perpetuate stigma instead of allowing people to connect to the positive."
Mental health issues affect over 40-million Americans, with suicide being the second leading cause of death for people ages 10 to 34, regardless of race, religion, and sexual orientation.
You can hear much more from Dr. Moutier, including her role in advising the Netflix series 13 Reasons Why and the potential for a new three-digit emergency number for suicidal counseling, in the full interview above.
If you or anyone you know is struggling with depression or anxiety, know that someone is always there.
Please check the RESOURCES YOU CAN USE on ImListening.org. Additionally, the National Suicide Prevention Lifeline is available 24 hours a day, 7 days a week at 1-800-273-8255.


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The Human Oncology and Pathogenesis Program (HOPP) was created in late 2005 under the leadership of Charles Sawyers, MD. The Program is working to assemble a group of outstanding physician-scientists with laboratory-based training in cancer research; build infrastructure for conducting clinical trials that incorporate powerful molecular profiling technologies; and provide a world-class training environment for graduate students, postdoctoral fellows, clinical fellows, and junior faculty who are interested in translational research.
To maximize the resources and advantages of this unique program, Dr. Sawyers sought advice from a panel of world-renowned research experts — known as the HOPP External Advisory Board (EAB). The EAB has provided invaluable input on the strategic planning for HOPP. EAB members help identify outstanding young recruits, provide information on the latest technology and research trends, and evaluate the research portfolios of HOPP faculty members and our core facility leader.
External Advisory Board Members
, is Director of the Broad Institute's Cancer Program, a Charles A. Dana Investigator in Human Cancer Genetics at the Dana-Farber Cancer Institute, an investigator at Howard Hughes Medical Institute, and professor of pediatrics at Harvard Medical School. Dr. Golub is a world leader in applying genomic tools to the classification and study of cancers. His research uses knowledge gained from the human genome to understand the biological and clinical challenges facing cancer medicine. He has made fundamental discoveries related to the molecular basis of childhood leukemia, and pioneered the use of genomic approaches, particularly DNA microarrays, to cancer biology. Todd Golub, MD
William Kaelin, MD, is a professor of medicine at Dana-Farber Cancer Institute and at Brigham and Women's Hospital, Harvard Medical School; Senior Physician at Brigham and Women's Hospital; and Associate Director, Basic Science, of the Dana-Farber/Harvard Cancer Center. He is also an HHMI investigator. His research focuses on understanding why mutations affecting tumor-suppressor genes cause cancer. His long-term goal is to lay the foundation for the development of new anticancer therapies that are based on the biochemical functions of specific tumor-suppressor proteins.
Sandy Markowitz, MD, PhD, is a Howard Hughes Medical Institute investigator and the Francis Wragg Ingalls Professor of Cancer Genetics in the Department of Medicine (Hematology-Oncology) and the Ireland Cancer Center, with co-appointment in the Department of Molecular Biology, at Case Western Reserve University School of Medicine. He is also an attending physician at University Hospitals of Cleveland. His laboratory focuses on molecular abnormalities in colon cancer, and is studying colon cancer suppressor genes and oncogenes, the functions of positive and negative regulatory growth factors, and the role of genomic instability in inherited and sporadic colon cancers.
Kevin Shannon, MD, is an Auerback Distinguished Professor in Molecular Oncology, Director of the Medical Scientist Training Program, and Interim Chair of the Department of Pediatrics at the University of California, San Francisco. He is also a pediatric hematologist and oncologist at UCSF Medical Center. His lab investigates the causes of leukemia, mechanisms of hematopoietic growth control and leukemogenesis, treatment response and resistance, and novel experimental strategies. These studies are conducted in human cells and mouse models.


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Yatir Cabernet Sauvignon 2006 – Yatir Winery is producing some of the finest wines coming out of Israel. The Yatir Cabernet Sauvignon is a medium body, dry, red wine made from grapes grown in the lower Judean Hills on the border of the Negev Desert Region. It is 85% Cabernet Sauvignon and 15% Petit Verdot, with its trademarked deep purple color. Expect an action packed, flavor attack on the mouth initially, with layers and layers of black fruit flavors, and a long sensuous finish. It should go great with any full flavored red meat dish.
Dry red wines should be served cool to the touch, but not chilled. It is a fine new world style Cabernet Sauvignon, which can be enjoyed by everyone, at the Shabbos table.
Goes perfectly with Rosemary and Garlic Baby Lambchops or Kosher Contessa Rack of Lamb Persillade
Mark Glicksman is certified by the International Wine Center in New York City, and frequently writes wine reviews for publications.
Subscribe Now for weekly freebies and recipes!
CLICK and Sign up for our free newsletter!


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A Doctor's Declaration of Independence
It's time to defy health-care mandates issued by bureaucrats not in the healing profession.
In my 23 years as a practicing physician, I've learned that the only thing that matters is the doctor-patient relationship. How we interact and treat our patients is the practice of medicine. I acknowledge that there is a problem with the rising cost of health care, but there is also a problem when the individual physician in the trenches does not have a voice in the debate and is being told what to do and how to do it.
As a group, the nearly 880,000 licensed physicians in the U.S. are, for the most part, well-intentioned....
To Read the Full Story


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! Click the image to see the animation. Use the movie controls to examine the planets.
The universe is mostly
empty space. Even in a "crowded"
region like our solar system, the distances
between planets are so vast that they are
difficult to imagine. This animation simulates
a voyage from the sun past all nine planets.
For convenience, the planets are lined up
in the same direction. The animation shows
each planet's average distance from the
At the speed of today's fastest spacecraft
(~20 km/second), it would take almost ten
years to travel this distance. Even at the
speed of light, the trip would last 5 1/2
hours. In this animation, the apparent speed
of the viewer is over 300 times the speed
of light.


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Rima Fakih has just one more week to go in her yearlong reign as Miss USA. A scrutiny-filled year after winning the title, Fakih is simply "proud to say that I am giving up my crown on June 19th and that I still have the crown."
From scandal over leaked photos taken at a pole dancing class to her time spent on the WWE: Tough Enough reality competition show, to bigoted comments about her being a Muslim, there's been no shortage of controversy following the first Arab-American Miss USA's year-long reign. Even in the past month she's been shamed for late-night partying after surveillance tapes surfaced that show her returning to her home at 4am.
When asked if we should all change the way we look a pageants, Fakih detailed the difference between a beauty pageant and Miss USA:
"I'd like to clarify something: you have beauty pageants... but then you have the Miss Universe organization and Miss USA. A lot of people don't understand that Miss USA is just a real woman ... She's a real human being, who has her own opinion, who's an adult who can make her own, mature decisions."
Miss USA Likes Pizza, Believes In Insurance-Subsidized Birth Control
Miss USA's Bigot Backlash And Stripping Scandal Begins Now!
Today In Ridiculous Responses To Miss USA Rima Fakih


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This site is the archived OWASP Foundation Wiki and is no longer accepting Account Requests.
To view the new OWASP Foundation website, please visit https://owasp.org
Project Information:template AppSensor Project
|Project Name
|OWASP AppSensor Project - Detect and Respond to Attacks from Within the Application
|Short Project Description
The AppSesnsor document is a conceptual framework that offers prescriptive guidance to implement intrusion detection capabilities into existing application utilizing standard security controls and recommendations for automated response policies based upon detected behaviour. When using AppSensor, an application will be able to identify malicious users whithin the application and eliminate the threat by taking response action such as logging out the user, locking the account or notifying an admnistrator.
An attacker often requires numerous probes and attack attempts in order to locate an exploitable vulnerability within the application. By using AppSensor it is possible to identify and eliminate the threat of an attacker before they are able to successfully identify an exploitable flaw.
A bit more detail
The goal of this project is to create the standard and guidance for how an application should detect, log and respond to malicious events. The deliverable for this project will be a framework of information which would be used by an application architect during the design of the system itself. This project would not create a tool or any code. Instead, it will build upon many of the IDS concepts developed in ESAPI and move towards a fully developed Application IDS Framework Standard. For example, when an architect considers the design of their authentication system (or any other critical system) they would reference the AppSensor guidelines on authentication. The AppSensor guidance will indicate what sort of authentication actions need to be logged (failed login attempt, use of multiple user-names from a single IP, high rate of login attempts etc) and
what information must be captured (user-name, ip, timestamp etc). Further, the AppSensor guidance will detail how all the events should be handled. Events will have different severities and will be sent to a centralized logging system within the application. This system collect the security events from throughout the application (authorization attacks, business logic attacks, force browsing attempts etc) and will then be able to take appropriate action against the user. This could include locking out an account, generating alerts to sys-admins, shutting down portions of the application, etc. Essentially, my project is defining how an Intrusion Detection System should be designed, configured and built into the code of any custom application. By building the Application Level IDS within the application itself, we are in the best place to capture and respond to all malicious actions performed against the application.
|Project key Information
|Project Leader
Michael Coates
|Project Contributors
(if applicable)
|Mailing list
Subscribe here
Use here
Creative Commons Attribution Share Alike 3.0
|Project Type
OWASP SoC 08
|Release Status
|Main Links
|Related Projects
AppSensor Beta Release 1.1 - Now Available!


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Pilot Study Of Sirolimus Plus Multiagent Chemotherapy For Relapsed/Refractory Acute Lymphoblastic Leukemia/Lymphoma (SIR-MO-1101)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01658007
Recruitment Status : Terminated (Slow Accrual)
First Posted : August 6, 2012
Last Update Posted : September 14, 2020
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
The investigators want to learn about treating relapsed/refractory lymphoblastic leukemia and lymphoma with a drug called sirolimus. The investigators are using sirolimus along with other cancer drugs that are often given to patients with relapsed leukemia and lymphoma.
The main purpose of this study is to determine if sirolimus can be given safely in combination with standard drugs used to treat relapsed lymphoblastic leukemia/lymphoma.
|Condition or disease
|Relapsed Lymphoblastic Leukemia Recurrent Adult Lymphoblastic Lymphoma Refractory Acute Lymphoblastic Leukemia Refractory Lymphoblastic Lymphoma
|Drug: Sirolimus
|Early Phase 1
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|3 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Pilot Study Of Sirolimus Plus Multiagent Chemotherapy For Relapsed/Refractory Acute Lymphoblastic Leukemia/Lymphoma
|Study Start Date :
|August 2012
|Actual Primary Completion Date :
|January 2017
|Actual Study Completion Date :
|January 2017
Experimental: Sirolimus
Adding sirolimus to established induction and consolidation chemotherapy for relapsed/refractory acute lymphoblastic leuk
Drug: Sirolimus
Adding sirolimus to established induction and consolidation chemotherapy for relapsed/refractory acute lymphoblastic leukemia
Other Name: Rapamycin, Rapamune
- Determine rate of dose limiting toxicities [ Time Frame: 35 days ]The safety of the regimen will be assessed by the occurrence of unexpected or severe adverse events attributable to sirolimus
- Number of participants with adverse events to determine maximum tolerated level of sirolimus in combination with chemotherapy [ Time Frame: 28 Days ]MAST (maximum acceptable sirolimus trough) will be the serum trough range at which fewer than one third of patients experience dose limiting toxicities during the observation period (28 days)
- Measure the number of residual leukemia cells in the bone marrow. [ Time Frame: At day 35 of induction and day 56 of consolidation ]Disease response will be assessed according to standard criteria
- Measure protein phosphorylation [ Time Frame: Samples collected at Baseline, Days 1, 3, 8 and 29 of induction and Baseline, and Days 1, 8, 29, and 36. ]Peripheral blood samples (5mL) will be obtained at day -6 (baseline), 1, 3,8, 29 of induction and day -6 (baseline), 1, 8, 29, 36 of consolidation for measurement of pAKT, p-S6, p70S6 kinase activity, and single-cell phosphoflow studies in peripheral blood mononuclear cells
- Tumor measurement by PET and/or CT scan [ Time Frame: After day 35 of induction and/or Day 56 of Consolidation ]Disease response will be assessed according to standard criteria
- Measure changes in sirolimus plasma concentration (ng/ml). [ Time Frame: 56 Days ]Use serial measurements of sirolmus trough levels and PK modeling to adjust individual patient sirolimus dose.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|up to 30 Years (Child, Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Age: Patients must be < 30 years of age at the time of enrollment
- Acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL)
- Histology: B-precursor or T-cell
- Disease status: first or greater relapse OR primary disease refractory to two prior induction attempts
- Patients with active relapse (> 5% bone marrow blasts if ALL, detectable disease by imaging with CT and/or PET scan if LL) without prior re-induction attempt are eligible for induction (block 1) therapy followed by consolidation (block 2) therapy
- Patients with documented history of relapse who have received alternative induction therapy are eligible for consolidation (block 2) therapy
- Patients with CNS involvement are eligible for the induction block with intensified intrathecal therapy. Those enrolling post-induction for the consolidation block must have cleared the CNS of blasts at the time of enrollment on this study. (See Appendix I for method of evaluating traumatic lumbar punctures.)
Performance status
-Karnofsky >/= 50 for patients > 10 years of age OR Lansky >/= 50 for children </= 10 years of age (see Appendix II).
Oral medication -Patient must be able to consume oral medication in the form of solution or have nasogastric tube placed for administration of medication.
Prior Therapy
- Patients who relapse while receiving standard ALL maintenance chemotherapy will not be required to have a waiting period before entry onto this study.
- Patients who relapse on therapy other than standard ALL maintenance therapy must have recovered from the acute toxic effects of all prior chemotherapy, immunotherapy, or radiotherapy prior to entering this study, unless deemed stable and irreversible by the investigator.
Recovery is defined as a toxicity grade < 2 as defined by the Common Toxicity Criteria Version (CTCAE) 4.0, unless otherwise specified in the Inclusion and Exclusion criteria.
- Cytotoxic chemotherapy: At least 7 days must have elapsed from prior cytotoxic chemotherapy regimen before initiation of treatment with sirolimus on this trial, including administration of treatment dosing of corticosteroids (physiologic replacement for adrenal insufficiency is allowed)
- Hydroxyurea: patients with peripheral blasts may receive hydroxyurea until the first dose of cytotoxic chemotherapy for cytoreduction.
- Hematopoietic growth factors: At least 14 days after the last dose of a long-acting growth factor (e.g. Neulasta) or 7 days for short-acting growth factor.
- Biologic (anti-neoplastic) agent: At least 7 days after the last dose of a biologic agent or donor lymphocyte infusion (DLI). For agents that have known adverse events occurring beyond 7 days after administration, this period must be extended beyond the time during which adverse events are known to occur. The duration of this interval must be discussed with the study chair.
- Immunotherapy: At least 6 weeks since the completion of any type of immunotherapy, e.g. tumor vaccines.
- Monoclonal antibodies: At least 3 half-lives since prior therapy with a monoclonal antibody.
- XRT: >/= 2 wks for local palliative XRT (small port); >/= 24 weeks must have elapsed if prior TBI, craniospinal XRT or if >/= 50% radiation of pelvis; >/= 6 weeks must have elapsed if other substantial bone marrow radiation.
- Stem Cell Transplant or Rescue without TBI: No evidence of active graft vs. host disease and ≥ 12 weeks must have elapsed since transplant or stem cell infusion.
Organ Function Requirements
Adequate Renal Function Defined as:
- Creatinine clearance or radioisotope GFR >/= 70ml/min/1.73 m2 or
- A serum creatinine based on age/gender as follows:
The threshold creatinine values in this Table were derived from the Schwartz formula for estimating GFR (Schwartz et al. J. Peds, 106:522, 1985) utilizing child length and stature data published by the CDC.
Adequate Liver Function Defined as:
- Total bilirubin >/= 1.5 x upper limit of normal (ULN) for age
- SGPT (ALT)</= 5x ULN.
Fasting serum cholesterol </=300 mg/dL AND fasting triglycerides </=300mg/dL. NOTE: If one or both of these thresholds are exceeded, the patient can only be enrolled after initiation of appropriate lipid lowering medication and improvement in laboratory parameters to meet eligibility.
Fasting serum glucose </= 160 mg/dL. May be achieved with insulin
Adequate Cardiac Function Defined as:
- NOTE: this applies for patients enrolling for induction block 1 only. Patients who do not meet these criteria may be eligible for block 2 therapy after alternative induction block
- Shortening fraction of >/= 27% by echocardiogram
- Cumulative prior anthracycline exposure must not exceed 400 mg/m2 (each 10 mg/m2 of idarubicin/mitoxantrone should be calculated as the isotoxic equivalent of 30 mg/m2 of daunorubicin or doxorubicin)
Hematologic parameters
- NOTE: this applies for patients enrolling for consolidation block 2 only. Patients enrolling for induction have no blood count requirements
- Patients enrolling for consolidation block 2 after receiving alternative re-induction not on study must have ANC >/= 750/uL, platelets >/= 75,000/uL and bone marrow with </= 5% blasts (M1).
Exclusion Criteria
Pregnancy or Breast-Feeding
-Pregnancy tests must be obtained in females of childbearing potential. Pregnant or lactating patients are ineligible for this study. Males or females of reproductive potential may not participate unless they have agreed to use an effective contraceptive method.
Patients With Uncontrolled Infection
- Patients must have any active infection under control. Fungal disease must be stable for at least 2 weeks before enrollment. Patients with bacteremia must have documented negative blood cultures for > 48 hours prior to initiation of treatment.
- Patients who have a known allergy to sirolimus, FK506 (cross-reactive), or other mTOR inhibitors
- Patients who have a history of asparaginase-associated pancreatitis ARE eligible but will have asparaginase omitted from therapy. Patients who have a history of E-coli asparaginase allergy will receive Erwinia asparaginase.
- Patients with active lung disease as defined by presence of pulmonary infiltrates on screening chest x-ray or baseline room air oxygen saturation of < 93%
- Patients with a known history of hepatitis B, C, or HIV
- Patients who, in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study
Concomitant Medications
- Hematopoietic growth factor(s): Must not have received within 7 days of entry onto this study for a short-acting growth factor, or within 14 days for a long-acting growth factor
- Azoles: Due to interference with sirolimus metabolism, voriconazole, itraconazole, fluconazole, and ketoconazole should be avoided and alternative antifungal therapy initiated. If one of these agents must be given, sirolimus dosing will be decreased by 80% and trough levels monitored every other day for the first week and then weekly per protocol.
- Calcineurin inhibitors: Must be off of tacrolimus and/or cyclosporine for at least 2 weeks prior to entry on this study
- Additional medications that interact with CYP3A4: See Appendix III of the protocol for medications to be avoided while receiving sirolimus. Patients should be off these medications at least 2 weeks prior to entry on this study. If the medication is deemed essential and cannot be discontinued, sirolimus dosing will be adjusted following discussion with the study pharmacologist, Dr. Vinks, depending on the degree of expected interaction. Levels should be monitored every other day during the first week, then weekly per protocol.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01658007
|United States, Ohio
|Cincinnati Children's Hospital Medical Center
|Cincinnati, Ohio, United States, 45229
|Principal Investigator:
|Maureen O'Brien, MD
|Children's Hospital Medical Center, Cincinnati
|Responsible Party:
|Children's Hospital Medical Center, Cincinnati
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
2012-0361 ( Other Identifier: CCHMC-IRB )
|First Posted:
|August 6, 2012 Key Record Dates
|Last Update Posted:
|September 14, 2020
|Last Verified:
|September 2017
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
|Product Manufactured in and Exported from the U.S.:
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Lymphoid
Lymphoma, Non-Hodgkin
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Anti-Bacterial Agents
Anti-Infective Agents
Antibiotics, Antineoplastic
Antineoplastic Agents
Antifungal Agents
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs