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LONDON (Reuters) - Tiny magnets have been used to deliver anti-cancer gene therapy in mice in a development that could make the treatment much more effective, scientists said on Thursday.
The idea behind gene therapy is to replace faulty genes. But the approach has had mixed success because of the difficulty of getting genes to the right part of the body.
One option has been to use viruses to carry genes but this risks triggering an immune system reaction.
Now British researchers think they may have cracked the problem.
By inserting magnetic nanoparticles into monocytes -- a type of white blood cell -- and injecting them into the bloodstream, they have been able to guide them around the body using an external magnet.
Using this technique, many more cells armed with anti-cancer genes reached and invaded malignant tumors, Claire Lewis of the University of Sheffield and colleagues reported in the journal Gene Therapy.
"The use of nanoparticles to enhance the uptake of therapeutically armed cells by tumors could herald a new era in gene therapy -- one in which delivery of the gene therapy vector to the diseased site is much more effective," Lewis said.
The new approach could also be used to deliver therapeutic genes to treat other conditions like arthritic joints or heart disease, she believes.
Clinical trials on humans, however, are still some way off.
Tests so far have involved treating tumors just under the skin of mice. The real goal is to attack tumors deep inside the body, which are normally the most serious.
"We're going to have to extend existing magnetic resonance, or MRI, technology to create a magnetic gradient over a deep tissue like the liver," Lewis said in a telephone interview.
Her team is also looking at the ability of magnetic targeting to deliver a variety of different cancer-fighting genes, including ones which could stop the spread of tumors to other parts of the body.
Gene therapy has been much hyped over the years as a treatment for cancer and other diseases where DNA is known to play a central role but scientists have run into a series of technical and safety problems.
In one trial in 1999 a patient died and in other cases children have developed leukemia as a result of such treatment.
"We would hope that this will be safer because we are using a natural mechanism in the body and patients' own white blood cells to deliver the gene therapy," Lewis said. "We're simply amplifying that with this magnetic approach."
Editing by Andrew Roche
Our Standards: The Thomson Reuters Trust Principles.


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Arts & Culture
The spiraling gyrations of Fred Tomaselli go on display at the Modern Art Museum of Fort Woth
Alison Hearst, the assistant curator at the Modern Art Museum of Fort Worth, has assembled her first Focus show for the museum using the work of New York City-based artist Fred Tomaselli.
She brought in Tomaselli's giant collages, which can take him months to create, and the front-page quickies that he makes while waiting for paint to dry on his big projects. For these time fillers, he takes the front page of The New York Times, scans it into his computer and reprints it on watercolor paper or perforated blotter paper, and then enhances the lead photograph, painting out parts and constructing fantastic backgrounds. The results are wonderful.
He began this series of collages, which numbers 85 pieces, in 2005, when he saw a photo of convicted CEO Bernard Ebbers leaving court with his wife, Kristie. The couple are clutching hands, and Tomaselli has obliterated their surroundings with brightly colored flowers and sparks, adding an additional layer of editorializing to the story.
He began to collect the newspapers, storing them in archival boxes and retrieving ones that spoke to him. Later that same year, he found the front-page photos of New Orleans flooded by levee breaks caused by Hurricane Katrina to be especially compelling. He highlighted the flooded streets with lines of bright colors so that the city is overlaid with a grid of what looks like a subway map. "The water line is sort of a toxic abstract," Tomaselli says.
Angry citizens and politicians are fodder for these works; in fact, three Texans have made his reconstructed covers — Gov. Rick Perry, and former U.S. Congressmen Ron Paul and Tom DeLay.
"This rogues gallery was a coincidence," Tomaselli says. "I can assure you I didn't know they were going to be shown in Texas." But they play well here in Fort Worth, as they strike a familiar note on a gallery wall filled with Times front pages.
Each day the newspaper is delivered to his doorstep is like Christmas, he says, as there is the potential for another art project with each disaster, political blunder or outrage.
What he paints on top of the photographs and what he uses to construct his large collage pieces provide additional information and emphasis, some of it accidental, and at other times, by insistence.
For his 15-foot-wide Flipper, made in the wake of Hurricane Katrina, Tomaselli looped his collage bits in ovals and circles, overlaying them so that the result looks like an oscilloscope patterning of voices.
"I wanted a sort of joyful noise," he says. "I wanted it to look like Mardi Gras beads. It is an abstraction of the beautiful chaos there."
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For his large resin-coated collages, he uses thousands of carefully snipped images of butterflies, flowers, weeds, birds, gems, body parts — anything he can find in abundance. Each little paper scrap is carefully placed in chains of swirling images and each layer is sealed with resin so that the finished surface has a depth that only can be experienced in person.
This, too, is purposeful.
"The relationship between a person and a real thing can't be replicated," Tomaselli says. "In this world of computerized imagery and information, it is almost strange to have an experience with a real thing. So to be able to see the surface quality and the depth, people have to see them in person. This is important to me."
The payoff for seeing them in person is worth the trip. Even though Tomaselli's main event is the large collage works, it is the little front-page pieces that may prove to have a longer shelf life. As timeliness recedes into past tense, they carry with them multiple interpretations, those of the staff of The New York Times — the reporters, editors and photographers — and then Tomaselli's as the last word, without any words. Later this year, a book of these images will be released, titled The Times.

subset: commoncrawl


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Our German tax calculator is free to use and will give you an instant tax refund estimation.
Are you married and want to claim a German tax refund? The tax rates in Germany for married or jointly assessed couples are significantly lower than the rates for single tax payers, so its worth checking if you're able to make a joint application with your spouse.
Employees in Germany can pay up to 42.5% income tax on their earnings. In most cases, you can claim back a significant amount of this. The refund amount is likely to be higher if you're married and filing jointly due to a higher tax-free allowance for married people.
What's more, your spouse doesn't even have to have travelled to Germany with you. If you're an EU or EEA resident and your spouse stayed at home when you were working in Germany, you can still apply jointly.
We work with a lot of people who didn't initially inform the German Tax Office that they were married and were subsequently taxed incorrectly. The average tax refund we get for our married and jointly assessed German tax clients is €1950. Talk to us today about how we can help.
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At taxback.com, we pride ourselves on providing a great service. We know that tax matters can be very complex so we take over all the tricky stuff so you don't need to worry about it. Once you sign the forms we need to proceed, we will prepare your German tax return and liaise with the German tax office on your behalf. You can keep fully up to date with all the progress on your refund by checking your Tax Tracker® account.
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Another one take today !
Been running longer get you more fun longer !!!
I'm hoping that nobody has seen a Summit like this before. It's mostly stock, though I am now running it on 2s lipos with the help of a Novak smart stop. Proline tech 5 wheels with Trenchers and the shell is a Proline Helios and I modified the Exo cage.
My short "classic climb"
Hello this is my first video, sorry for the quality, and still searching how to put some music in there.
The green Summit it's a stock one and the red Summit (mine) has a tekin brushless, thats why i run softer.
Hope you like it.
custom summit crawler parts lol
Playing in the bit of snow we got.trenchers work pretty good in the snow
Mountains cant stop me
they have tried
reposting my videos from my intro thread..
I stumbled across a bunch of old videos.. There on my YouTube page.. I'm going to make a compilation vIdeo but I'm super tired right now.. But here's a decent one..
i caught a second wind and decided to make those videos..
heres one at the beach..
and a night video.
i was going to add this one to my last post but it wont let me edit it..
Last edited by ksb51rl; 01-28-2012 at 09:53 PM. Reason: language
custom summit crawler parts lol
custom summit crawler parts lol
Youtube Search- Tommy Wooten RC
All of my Summit videos. These are dated from oldest to newest. I think that my newest videos are getting better. There is definitely a HUGE difference between the older ones and the newer ones. Mainly because of the camera.
Hope you enjoy
Last edited by larsen8; 01-31-2012 at 11:24 PM.
Why can't other people share my opinions?
my first attempt on POV video
Hello, here's my summit in the snow by 5°F, hope you enjoy!
some jumps and doughnuts and stuff. only upgrade is the mudslingers and the broken body mount while making this video.
custom summit crawler parts lol
custom summit crawler parts lol
forest exploration with Traxxas Summit [POV]
first drive of the morning.. another video coming soon.
custom summit crawler parts lol
second run of the day, i was having trouble getting into reverse because i dunked it in the river to clean it after the first run.
custom summit crawler parts lol
I took my summit out this past weekend with my camera crew(my friends lol) heres how it turned out
Our latest ride through the rocks..
Celebrating 200 subscribers
Working video
A little film of my summit
This is my stock Summit on a little crawl. Sorry for the quality, my phone was clipped to my belt, and at one point I was more concerned with getting off the log rather than where the camera was pointing.
The 2nd vid is it going up and back down some steps.
Last edited by bigjaybo77; 03-02-2012 at 12:44 PM. Reason: Addition of link
Put the beast on the scale. What are you coming in at?
summit at play. stock with mudslingers, dewalt and other goodies on the way.
Couple more short clips. Still stock! The first one is pretty cool!
Here's another Snow Ride !!
My new 2012 Summit!
Last edited by Netcruzer; 03-11-2012 at 12:17 AM.
Traxxas Summit driving in snow with chains.
Here's the new link, the other song had a copyright !!
Great vids everyone! Heres my latest adventure, notice the new tailpipes! Gotta have'em!
My Summit Review vid:
My Secondary Vid (terrible and not nearly as good)
XO-1 Supercar
Hi, here's my summit with mamba monster inside


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Time for another edition of Christmas shaming, in which we examine the wish lists of your friends, loved ones, and co-workers. It's a look into the strange wants and materialistic hearts of those who dwell among us. So keep sending them in. Anonymity guaranteed.
Today's comes to us from the distant past, when people still used Microsoft Publisher. The sender-inner tells us that Chris's wish list was mistakenly saved to his office's shared network drive. Judging from the DVDs he wanted, we can peg the year at 2004—which means he was all about Eli Manning during his rookie year. That also means Donald Trump's necktie brand didn't yet exist. As our tipster says, Chris just wanted ties that looked like the ones Trump and George W. Bush wore.
There is something delightfully soulless about the notation "will advise" on a wish list.


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'The Simpsons' predicted Super Bowl XLVIII in 2005
The line on Super Bowl XLVIII is the Broncos by -2.5, with a total score of 48, according to The Linemakers, but let it be known that "The Simpsons" called their shot on this one way back in 2005.
#thesimpsons predicted it! @SuperBowl forecast in the "Bonfire of the Manatees" (S17) episode from 2005. #SB48 pic.twitter.com/cEPfaQlRrM
— The Simpsons (@TheSimpsons) January 31, 2014
So if you're a big believer in "The Simpsons," take the under and the Broncos to cover. SB Nation also points out a question for the ages: Homer Simpson's ownership of the Denver Broncos.
We can only assume that means the Simpson family is all-in on Papa John's for their game day meal.


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AT&T AdWorks Aligns within AT&T's Home Solutions Group
OREANDA-NEWS. June 08, 2012. AT&T AdWorks today announced its new alignment as part of AT&T's Home Solutions group. With the new strategic alignment, AT&T has appointed Mike Welch as president of AT&T AdWorks. Welch will report to Jeff Weber, president for Content and Advertising at AT&T. The appointment is effective immediately.
AT&T's Home Solutions division oversees U-verse® TV, broadband and voice services for AT&T's 22-state local wireline operations. AT&T AdWorks will continue to grow its multiscreen advertising offering, which includes TV, mobile and online platforms.
Since AT&T AdWorks' rebranding a year ago, it has experienced accelerated growth and presence in the marketplace and it works directly with national brand clients and specialized media agencies.
"I am pleased to join AT&T AdWorks at such an exciting time," said Welch. "Due to the new strategic alignment, AT&T AdWorks will be better equipped to help our clients connect all the pieces - making it easy to buy, manage, and analyze multiplatform campaigns."
Prior to his current appointment, Welch was vice president of Sales for the Southwest Region of AT&T Advertising Solutions. Previously, he held several executive level positions with AT&T spanning Consumer Services, AT&T Business Solutions and Sales Operations. He joined AT&T in 1997 after spending seven years in sales at The Pillsbury Company.


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Next: ax_dist_rpm, Previous: ax_dirname, Up: The Macros
Adds support for a msi (Microsoft Installer) dist target.
You must manually build the msi file yourself (probably from another computer). But it will be added to the list of extra bin dists and flagged for uploading (see ax_extra_dist.m4 and ax_upload.m4 for details).
Download the latest version of ax_dist_msi.m4 or browse the macro's revision history.
Copyright © 2009 Tom Howard firstname.lastname@example.com
Copying and distribution of this file, with or without modification, are permitted in any medium without royalty provided the copyright notice and this notice are preserved. This file is offered as-is, without any warranty.


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SAN FRANCISCO – Speakeasy Ales & Lagers, one of San Francisco's favorite local brewers since 1997, has partnered with DIY/Indie Mart maven Kelly Malone to transform an underutilized corner of the brewery into a full-time tasting room and retail space. The dark, subterranean space was perfectly suited for creating a "speakeasy" ambiance, complete with secret hideaways, vintage-inspired lighting and, of course, a heavy duty door with working peephole.
Built almost exclusively with salvaged and recycled materials, the Speakeasy Tap Room will have a rustic, industrial aesthetic with period nods to the era of flapper girls and bootlegging.
"We wanted to take advantage of the vibe of the space to create something that would evoke a real 1920's basement speakeasy," said Director of Sales, Brandon Borgel. "We're excited about the opportunity to bring people out here for a unique experience, tour the brewery and enjoy a brewery-fresh beer with us."
Coinciding with the start of SF Beer Week, the Speakeasy Tap Room will debut on Saturday, February 9, with events planned daily throughout the week. The new space boasts 12 Speakeasy beers on tap, exclusive merchandise, and some beers you might not find anywhere else:
"The Tap Room will allow us to experiment with new ideas and get feedback at the source," says Head Brewer, Kushal Hall. "We put the taps a few feet from my office door, so justÔǪknock."
Customers can create their own tasting flights and take their favorite brew home, either in a refillable growler or in one of the brewery's many bottled varieties. For those who want to enjoy their IPA amidst the stacks of kegs and grain, the brewery's popular Friday Happy Hour will live on as the newly christened Brewhouse Bar, open Fridays at 3 pm and featuring $3 beers until 5 pm.
Although the Speakeasy Tap Room won't be serving food, look for local food trucks such as Le Truc, Del Popolo and The Rib Whip to make appearances during Beer Week. For a full listing of Speakeasy's SF Beer Week events, visit sfbeerweek.org. Speakeasy Ales & Lagers is located at 1195 Evans Avenue, San Francisco, CA. Hours are Tue- Thu 3-8 pm, Fri-Sat 1-9 pm, and Sun 1-6 pm. For more information about the Speakeasy Tap Room, call (415) 642-3371 or visit goodbeer.com.


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Dishwasher does not switch on, no light on the panel
If the dishwasher does not switch on, no light on the panel, refer to the suggestions below for step by step instructions.
Is the dishwasher plug inserted in the socket and switched on?
- Check that the plug is inserted and that the socket is switched on.
Does another appliance work in the same socket?
- You can check whether there is power at the socket by plugging in another appliance and seeing whether that works as it should.
- If the socket does not work, contact a local electrician to help resolve the problem.
Has one of your relays tripped or has a fuse blown?
- Reset the circuit-breaker / RCD device or replace the fuse
- You can reset the circuit-breaker by pushing the switch to the "ON" position.
The circuit-breaker may look like one of those shown in the images below:
Older-type fuse box system may look like one of those shown in the images below:
If the above suggestions do not resolve the issue, we recommend requesting a visit by a service engineer.
To help you determine the exact nature of the problem, we recommend a visit by one of our authorized engineers to check the appliance and fix the problem.
When contacting us, please have the following information to hand. You will find this information on the manufacturer's data plate:
- Model number
- Product number (PNC)
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Data plate with model number, product number/PNC, ELC and serial number:
[3–9999] Where will I find the data plate on my product?
NOTE: Depending on the problem, you may be charged for a service visit by an engineer, even during the warranty period.
Make a note of the reported error code and quote it when you request an engineer. This will not solve your problem, but it will help our engineer identify the cause of the problem.
- Report error code: C1
Warning: We do not recommend using the product until the problem has been completely fixed. Unplug the product and do not plug it in again until you are certain that it is OK to do so.
You can request a visit by one of our engineers by clicking on the link below.


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If you have gone through our training and would like to volunteer in this, view the Volunteer link in the "Get Involved" menu.


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White & Red Split Lycra Spandex Zentai SuitProduct Code: MZ015
Availability: In Stock
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Mumbai: Actor-producer Dino Morea`s DM Fitness will be unveiled by his ex-girlfriend Bipasha Basu. Though they are not together as a couple, the actor claims that the two are great friends even today.
The fitness brand, which will allow people to come and walk or jog at the property without paying any money, will be launched Sunday in Worli Seaface.
"Bipasha is a fantastic human being. She has always been there for me and even I have always been there for her," Dino, who dated her in the late 1990s and even worked with her in the hit movie 'Raaz', told reporters.
"I share a very great relationship with her right now. Yes, we were dating each other at one point of time and people tend to overlook it at the other way. We are very close to each other and we share a very strong bond."
After dating for about five years, the two drifted apart and Bipasha started dating John Abraham. However, she broke up with John as well.
When asked why he asked Bipasha to launch the fitness brand, Dino said: "Bipasha is known for her fitness. I wanted someone who has got enough knowledge about it. She is fantastic and she can talk about it."
Dino`s fitness centre is free for health conscious people.
"I am very excited about it. I want to give something back to my city. People who can`t afford gym, can walk here, which is for free of cost. We give the people an opportunity to exercise. It`s a functional training," said the 37-year-old who has been part of filmdom since 1999, when his first film 'Pyaar Mein Kabhi Kabhi...' came out.


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United Kingdom: The recent snowfall across the United Kingdom brought forth an array of snow sculptures, including Daleks! Areas reported include Leicester and Faversham, plus a number of photos published by the official Doctor Who Facebook page.
Speaking of Daleks, another was to be found at a chip shop in Helston! It was built by proprietor Marc Stonham, who said: "I've been thinking about it on and off for the last 40 years. It wasn't until last (year) that I actually did it. People do mention it and come and have a look." [Falmouth Packet, 17 Jan 2013]
The islanders of Cumbrae in Scotland hope that John and Carole Barrowman's Hollow Earth books will boost tourism. Paul Watling, of Visit Cumbrae, reported: "We've had visits from a number of Hollow Earth fans and last week, a group of about 14 came over. They were from all across France and Germany and were very keen to see the island. I showed them some of the locations used in the book and they loved their visit. We hope the books will do for Cumbrae what (tv series) Balamory did for Mull." [Daily Record, 13 Jan 2013]
The Rainbow pub in Digbeth has been re-opened with a retro theme, including a photo booth masquerading as a police box! Other features include a "Del Boy" cocktail bar and a Scalectrix set to play with! [Birmingham Mail, 1 Feb 2013]
United Kingdom / Australia: A Doctor Who postcard has sailed the seven seas from Sunderland (England) to Perth (Australia)! Schoolboy Cade Scott released the card in a bottle in August 2011, and was found by Matthew Elam this last Christmas Day, who responded back in January. Cade said: "I had got some Doctor Who postcards in a magazine and decided to use one of them to put in the bottle. I was just amazed it had gone so far. I thought it had sunk in the North Sea." [Sunderland Echo, 18 Jan 2013]
United States: Two special screenings of Doctor Who are to take place at the Rockland Public Library in Maine, as part of a series of literary, film and music evenings. The Sun Makers is to be shown on the 7th February, with Blink the following 14th. Admission is free. [Penobscot Bay Pilot, 28 Jan 2013]
Crochet versions of each of the Doctors have been made by Allison Hoffman from Austin, Texas; she explained: "I made the dolls for a woman that wanted to give her husband a Christmas present that would blow him away. He is a huge Doctor Who fan and she knew he'd love these toys. He's actually building a custom cabinet to display them now! Before taking on this project I had only seen the newer Who and not very many episodes, but now I feel like I know all of these people personally!". No prizes for guessing her favourite: "Tom Baker - I loved making that scarf!" [Metro, 29 Jan 2013]
Astrophysicist Neil deGrasse Tyson recently discussed "What is Time?" on his StarTalk Radio, comparing views of how Time travel is portrayed as linear, branching and, in Doctor Who's case, wibbly wobbly! [StarTalk Radio via YouTube, Jan 2013]


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UCONN WOMEN: UConn dominates Marquette 85-51
MILWAUKEE >> If the last couple of days of practice proved anything it was that hoisting up the most 3-point attempts in program history in the UConn women's basketball team's last game was one record that did not please the Huskies' Hall of Fame head coach.
So when the third-ranked Huskies went to work preparing for Saturday's Big East game against Marquette, the top priority was establishing a low-post presence.
It was hardly a coincidence that the first UConn got the ball in the 85-51 victory on Saturday afternoon, Kelly Faris floated a pass to Stefanie Dolson in the paint. Dolson finished with ease and scored almost at will within the shadow of the basket.
"As Coach said we put an emphasis of getting the ball inside and our guards did a great job of delivering it to me and giving me good passes," Dolson said. "I think we did a good job of getting the ball inside/out and having a good balance."
The balance involved Dolson hitting 9 of her 11 shots while Kaleena Mosqueda-Lewis was 9 of 13 from the field en route to a game-high 24 points.
"We talked a lot about that the last couple of days," Auriemma said. "We made it a point the last couple of days to get Stefanie the ball as much as possible. We did and I think that created a whole other set of problems with Marquette. I thought the ball movement was great that first 20 minutes. We got the exact shot we wanted to get most every time down the floor. It has been a while since we have come out with that kind of focus to start games and it was good to see."
UConn (14-1, 2-1 in the Big East) scored the game's first 11 points and led 17-4 before the crowd of 2,684 inside the Al McGuire Center were able to get comfortable.
Brianna Banks had 12 points, Kelly Faris added 11 points, five rebounds, eight assists and five steals (moving by Sue Bird and into the No. 10 spot on UConn's career charts). Morgan Tuck, not cleared to play until a few hours before the start of the game, added seven points, nine rebounds and five assists.
The news was not all good. Bria Hartley, who missed more than a month of preseason camp as well as the first two games of the season with a sprained ankle, only played five minutes in the first half before hurting her ankle again. After getting her ankle re-taped, she headed into the locker room and did not return until the start of the second half. However, Hartley did not play again as Moriah Jefferson started the second half.
Sarina Simmons led Marquette (8-6, 0-2) with 19 points.
UConn freshman Breanna Stewart missed the game due to a sprained ankle. Stewart injured her ankle in Friday's practice and will be reevaluated when the Huskies return home.
"Bria just rolled her ankle," Auriemma said. "We are waiting to see tomorrow or something but she rolled and it is the same one that was bothering her before. I thought it was best don't push your luck. Breanna Stewart stepped on somebody's foot yesterday, turned her ankle and that was that. There is not much you can do about those things. I am hopeful that both of them will be back on Tuesday. Some sprained ankles are worse than others so we will see."


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Cablevision Will Accept Binding Arbitration With ABC Disney, Calls for Return of ABC to Viewers In Time for Oscars
BETHPAGE, N.Y., March 7 -- Cablevision Systems Corporation (NYSE: CVC) today said it would agree to government calls for binding arbitration with ABC Disney in order to immediately return ABC to Cablevision customers. ABC Disney pulled ABC off Cablevision last night at midnight as negotiations continued on a new agreement, removing the channel from more than 3 million New York area homes.
Earlier today, U.S. Senator John Kerry and other leading officials urged ABC Disney to restore ABC to Cablevision customers and suggested arbitration to resolve the dispute.
Charles Schueler, Cablevision's executive vice president of communications, said:
"We remain deeply disappointed that ABC Disney has put their own financial interests above their viewers and pulled the plug on ABC. Given the extraordinary public interest in this matter, Senator Kerry and other public officials have suggested that arbitration is appropriate in this highly unusual situation. Thus, Cablevision will agree to binding arbitration and calls upon Disney CEO Bob Iger to immediately return ABC to New York area viewers, and join us in binding arbitration to resolve this matter fairly. We have communicated our position to the highest levels of the FCC and urged the agency to appropriately involve itself in this process."
Cablevision has been able to reach agreement with every other major broadcaster in New York, and has proposed to ABC Disney terms for ABC that are as good or better than the terms in all these agreements. Over the last few days, more than 70 elected officials at the federal, state and local level called on ABC Disney to keep ABC on Cablevision while the companies worked in good faith to reach a fair agreement.
Cablevision customers interested in current information on the ABC Disney matter can visit http://www.cablevision.com/abc.
About Cablevision
Cablevision Systems Corporation is one of the nation's leading telecommunications, media and entertainment companies. In addition to its Optimum-branded cable, Internet, and voice offerings, the company owns and operates News 12 Networks, MSG Varsity and Newsday Media Group. Cablevision's assets also include Rainbow Media Holdings LLC and its programming and entertainment businesses, AMC, IFC, Sundance Channel, WE tv and IFC Entertainment, as well as Clearview Cinemas. Additional information about Cablevision is available on the Web at www.cablevision.com.


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"Randy Cunningham: 9th Grade Ninja," an action-packed, animated comedy series that follows the adventures of an unlikely hero who, with his super human ninja suit, the 'NinjaNomicon' (an 800 year-old Ninja guide) and the help of his best buddy Howard, finds himself as the one thing protecting his school and the world from certain destruction, is set to premiere on Disney XD. A special preview will air MONDAY, AUGUST 13 (9:00 p.m., ET/PT) with the series premiere on MONDAY, SEPTEMBER 17 (7:00 p.m., ET/PT). New episodes will premiere Monday through Thursday (7:00 p.m., ET/PT).
Created and executive produced by Jed Elinoff and Scott Thomas ("Scooby-Doo"), "Randy Cunningham: 9th Grade Ninja" stars an award-winning cast: Ben Schwartz ("Parks and Recreation," "House of Lies") as Randy Cunningham, Andrew Caldwell ("Transformers," "Hannah Montana") as Howard Weinerman, Kevin Michael Richardson ("The Penguins of Madagascar") as Willem Viceroy III, John DiMaggio ("Futurama") as Hannibal McFist, Dave Wittenberg ("Stitch!") as Bash Johnson, Jim Rash ("Community") as Principal Slimovitz, Tim Curry ("The Rocky Horror Picture Show") as The Sorcerer, Megan Mullally ("Will & Grace") as Mrs. Driscoll and John Oliver ("The Daily Show with Jon Stewart") as Coach Green.
The multiplatform roll-out is as follows:
Saturday, August 11
Full episode preview of "Randy Cunningham: 9th Grade Ninja" is available on WATCH Disney XD.
Monday, August 13
A full episode preview of "Randy Cunningham: 9th Grade Ninja" follows the premiere of Disney's Magic of Healthy Living "TRYathlon" special (9:00 p.m., ET/PT). In the episode "Last Stall On The Left," Freshman Randy Cunningham discovers the 'NinjaNomicon,' which reveals that he has been chosen to be Norrisville's newest Ninja. Armed with his power-packed ninja suit, he faces his first battle with McFist's monster Krakenstein, while juggling his new secret identity and being there for his best friend Howard.
Directly following the preview on air, "Last Stall On The Left" will be available on iTunes as a free download.
DisneyXD.com launches a "Randy Cunningham: 9th Grade Ninja" page featuring a new side-scrolling platformer game, "Randy Cunningham: Punchocalypse," with intense action and high flying ninja moves.
Wednesday, August 29
"Enter the NinjaNomicon" activity launches on DisneyXD.com/Randy, allowing players to take control of Randy within the NinjaNomicon. In the activity, an evil force has scattered the pages of the NinjaNomicon and thrown it into chaos, and it is up to the player to put them back in order. Players will be able to access a special power in the activity called "Cold Rage" that can be used in the "Randy Cunningham: Punchocalypse" game.
Friday, September 14 - Sunday, September 16
Jason Dolley and Bradley Steven Perry ("Good Luck Charlie") host the nightly programming lineup on Disney Channel and give viewers a "Randy Cunningham: 9th Grade Ninja" sneak peek and highlights of the new series.
Monday, September 17
Series premiere (7:00 p .m., ET/PT) - In the episode "Got Stank," after triangle-playing band geek Bucky is benched for showboating, he is 'stanked' by the Sorcerer's noxious gas which turns him into a crazy monster creating mayhem at Norrisville High. Randy must learn the secret to saving Bucky who has fallen under the influence of the evil Sorcerer's powers by destroying the one thing Bucky holds most dear.
At DisneyXD.com/Randy, all five levels of the "Randy Cunningham: Punchocalypse" game will launch. Players take on the role of Randy, who equipped with his battle skills and ninja gear must rescue best pal Howard from their rivals.
Tuesday, September 18
"Randy Cunningham: 9th Grade Ninja" episodes available on WATCH Disney XD, Disney XD Mobile VOD via AT&T U-Verse, Sprint and Verizon; along with iTunes, Xbox Live and Sony Playstation. Select episodes will be available on DisneyXD.com.
Thursday, September 20
A new episode of "Randy Cunningham: 9th Grade Ninja" will be available on WATCH Disney XD.
"Randy Cunningham: 9th Grade Ninja" is a production of The Walt Disney Company Limited in association with Robin Red Breast, Inc. (a subsidiary of Titmouse, Inc.) in Los Angeles and Boulder Media in Dublin, Ireland. It carries a TV-Y7-FV parental guideline.
Disney XD is a basic cable channel and multi-platform brand showcasing a compelling mix of live-action and animated programming for Kids age 6-14, hyper-targeting boys and their quest for discovery, accomplishment, sports, adventure and humor. Disney XD branded content spans television, online, mobile and VOD platforms. The programming includes series, movies and short-form, as well as sports-themed programming developed with ESPN. In the U.S., Disney XD is seen on a 24-hour, advertiser supported network that reaches over 78 million households via its basic cable and satellite affiliates.


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Two weeks from today - I'll be in California. Last week I talked about the process of actually getting there. Well, there is a lot of work to do here first.
I have printed off new "business" cards, to share with new friends. And I put surnames on the back. Hopefully, I'll run into some cousins and we can work together on some of these problems. Son and daughter-in-law know that we'll be arriving in Anza on Tuesday, the 2nd, but that Walt will drive me to Burbank on Wednesday. But then, after Jamboree, we'll have more time to visit and watch the last week of youth baseball.
I still need to do all of the usual things like stopping the newspaper, scheduling the mail vacation hold, etc. BUT, more importantly in my mind right now, is getting up to speed on my DNA stuff. And, oh, do I need help!!!
Last year I attended the DNA day. I was overwhelmed. Well, this year I'm a little better prepared. I've sent in all of the DNA tests and received some of the results. But I'm very confused about what they are and what to do with them. So, I'm getting them ready.
I bought or borrowed many of the books regarding DNA that were on last years SCGS Jamboree DNA Day syllabus, and I've been reading them. Some are fairly straightforward. Some are still very much over-my-head. I'm also fortunate to be going to GRIP and I am in the DNA Course there. So, I have the recommended books for GRIP and I'm trying to read them. Again, some are fairly easy and entertaining; some are a real challenge. Anyway, I'm preparing and I know I have two weeks to read/skim them, write down questions, get my DNA numbers organized so that I can, hopefully, understand how to make comparisons before the end of Thursday, June 5.
As I said, there is a lot of work to do here before I leave, but most of it is my preparation for DNA day. I hope to see you there. And perhaps we'll find out that we're cousins.


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Please retune your television, you can do this by choosing Menu>Setup>Auto Tuning.
If this doesn't help check your antenna cable (unplug the cable and then re-connect it)
Also check whether another digital TV works fully on the same aerial; if not then you may have an antenna problem. A professional aerial installer can advise you.
Please note: During digital roll out in the UK, you may experience temporary problems. We would recommend checking the digital website for local information (http://www.digitaluk.co.uk/)


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Dentists diagnose and treat problems with teeth and tissues in the mouth, along with giving advice and administering care to help prevent future problems. They provide instruction on diet, brushing, flossing, the use of fluorides, and other aspects of dental care. They remove tooth decay, fill cavities, examine x-rays, place protective plastic sealants on children's teeth, straighten teeth, and repair fractured teeth. They also perform corrective surgery on gums and supporting bones to treat gum diseases. Dentists extract teeth and make models and measurements for dentures to replace missing teeth. They administer anesthetics and write prescriptions for antibiotics and other medications. (From the online Occupational Outlook Handbook, 2010-2011)
A degree in Dentistry is a four-year professional degree. Students attend dental school after they have completed an undergraduate degree or a minimum of 90 semester hours toward a degree. Students who participate in the Deferred Admit Program (See "Early Admission") must complete an undergraduate degree or 120 semester hours before matriculation to the College of Dentistry. Occasionally, those who enter after three years complete an undergraduate degree by applying their first year of dental school work as 30 credit hours of elective credit toward an undergraduate degree.
Application Process
Academic Guidelines
An overall GPA of 3.5 or above (on a 4.0 scale) is the preferred GPA for consideration for admission at most Colleges of Dentistry. The average GPA for the fall 2011 class at UIC College of Dentistry was 3.66. The science GPA average was 3.60; this GPA includes grades in biology, chemistry, physics, math, statistics and computer science courses.
Non-Academic Guidelines
Visit the College of Dentistry: Any student who wants to assess dentistry as a potential career is encouraged to visit the UIC clinics. When you go, make sure to make arrangements in advance and go dressed professionally.
Shadowing: While there is no formula for hours spent volunteering, working, or shadowing in a dentistry clinic, any exploration of the field helps students make more informed decisions regarding their suitability for a career in dentistry.
The Application Process
All U.S. dental schools require applicants to take the Dental Admissions Test (DAT). Most schools (including the University of Iowa) use the American Dental Education Association (ADEA) for initiating an application. ADEA sponsors the online Associated American Dental Schools Application Service (AADSAS). Students should check the ADEA Official Guide to Dental Schools for deadlines at other schools and should apply well before listed deadlines.
Diversity in Dentistry
ADEA has stated that the number of graduates of dental and allied dental programs should reflect their representation in the population and the communities in which they will serve, and that recruitment, retention and graduation of practitioners from disadvantaged groups are goals that are important for the public's health (from the ADEA website).
Many Colleges of Dentistry have a summer enrichment program that, prior to matriculation, helps admitted students acclimate to the College. Students are encouraged to contact their pre-dentistry advisors, and the individual dental schools, for more information.
Entrance Examination Requirement (DAT)
It is preferred that the DAT is taken no later than August of the calendar year preceding the year in which the applicant wishes to enroll in the Dental College. Students register online at www.ada.org. The test consists of four sections: a Survey of Natural Sciences (biology, general chemistry, and organic chemistry), Reading Comprehension, Quantitative Reasoning, and Perceptual Ability. Two summary scores are reported, one on academic subjects and one for perceptual ability, as well as scores on individual sections. The scoring range is from 1 to 30. The average score for students accepted into the UI program is 19 for each subtest. The current national average is between 17 and 18.
Letters of Evaluation/Recommendation
Letters of evaluation will be required of applicants. Letters from a faculty member, dentist or physician, academic advisor, or employer would be appropriate. Information about the non-academic character of a student would be most useful as academic information is already in the application. Students should have their evaluation letters submitted directly through AADSAS.
Most schools screen applicants with some form of personal interview. The UIC College of Dentistry interview consists of structured and unstructured components and is conducted by two individuals, one of whom is an Admissions Committee member.
In general, applicants needed a 3.50 GPA or greater to be considered for interviews in 2011; however, there were some exceptions. Admission is based on GPA, DAT scores, research interest or experience, community involvement, leadership qualities, the interview, the essay, and letters of recommendation. The Admissions Committee consists of ten faculty and two dental students (all voting members), as well as three ex-officio members.
Criminal Background Checks
Prerequisite for enrollment in the Colleges of Dentistry is consent for an external background check. This check includes, but is not limited to, past criminal offenses and registry information. If there is evidence of arrest for a crime(s), conviction for a crime(s), presence on an abuse registry, or other information which reasonably suggests that patient safety might be compromised, the student will be asked to provide additional information.
Citizenship/International Students
Dental schools vary as to whether they accept non-U.S. citizens. Some schools that do accept non-citizens require a substantial financial commitment up front. Since not all schools accept non-citizens and since the financial commitment of those that do may be substantial, students should thoroughly research and carefully consider such a decision and discuss it with their pre-dental advisors early in their undergraduate years.


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Are you somebody who enjoys creativity? We are building you the ultimate playground. We are creating an online environment which will help creative people to thrive. We are here for the creators. The artists, photographers, writers, musicians, and videographers.
We launched creative.ly, which lets you collect the creative images that you like most from the web. Making and browsing collections of images can be especially enjoyable. The site is friendly and fun. And before long, we will add tools to help artists share and manage their own creations. The site that's live is great, but this is only the beginning of the world we are creating.
Creative content is everywhere, but if you follow the money trail, the artists are inevitably being treated unfairly. We will be fixing this. First we've created a fun site for searching, collecting, and finding creativity on the Internet. This is in place, and is continuing to grow. Sool we will start implementing our revolutionary plans improving search and discovery of creative content. Then we add a marketplace. We've done the business and financial planning with care. We have better technology and social solutions. Artists get the lions share of the profit. And the site will help connect consumers with what they actually want most. We solve a variety of efficiency and social problems with fun fairly intuitive, yet underutilized solutions.
We will be the best, most innovative site for finding and sharing creative content. Creators will be given essential tools they have been missing. We will help artists connect with their audience. When creators want to sell their creations, we will offer realistic easy options. The community will enjoy new ways of having a great time with the art and each other.


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Break jewels like a king in Pawn'd! Match-3 meets Chess. This addictive game combines the strategic thinking and unique moves of chess with fun, gem-shattering, puzzle-game action.
REVIEWS (from Pawn'd)
"Gameplay: 5/5" - The-App-Shack.com
"Pawn'd is a match 3 game that aims to make things a little bit different, and it succeeds greatly." - AppChronicles.com
"Bejeweled has just been PAWN'D!" - "Lork Gek" App Store Review
"An absolute must buy for fans of chess games, match-3 games, or fans of innovative genre blending games." - Examiner.com
Each piece has simple but unique moves inspired by chess and perfected for match-game action.
Several modes of game play provide unique challenges. Can you break the poisoned piece in a just a few moves? How long can you keep playing while finding only matches of 4 or more? Can you fight off the ivy growing over the board? Tired of deep thought? Try matching as many pieces as you can before time runs out!
Never played chess? No problem! Fun practice games and touch-a-piece hints make it easy to pick up...and even harder to put down.
Simple to play, but tough to master. Are you ready to get Pawn'd?
When you purchase the Unlimited Coins, several new game modes are unlocked!


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Samuels, Bravo lift West Indies in 2nd Test
Marlon Samuels hit a fighting century to help the West Indies reach 241-2 at the close on the second day of the second and final Test against Bangladesh on Thursday.
The 31-year-old Jamaican Samuels was 109 not out and added 198 runs for the unfinished third wicket stand with Darren Bravo (85 not out) to help the tourists recover from the early loss of the openers at Sheikh Abu Naser Stadium.
The tourists, who lead the series 1-0 after winning the first Test in Dhaka by 77 runs, are now 146 behind Bangladesh's first innings total of 387.
Samuels, a star in West Indies's World Twenty20 triumph in Sri Lanka last month, drove spinner Shakib Al Hasan towards cover for his 11th boundary to complete his fifth Test hundred -- and his third this year.
By the end of play he had hit 13 boundaries and a six during his 231-ball resistance-filled knock after Kieran Powell (13) and Chris Gayle (25) were dismissed in the pre-lunch session.
Bravo, who hit seven boundaries during his sedate 197-ball knock, helped Samuels set a new record for third wicket against Bangladesh, beating the 179-run stand between Brian Lara and Ramnaresh Sarwan at Kingston in 2004.
Powell, who scored a century in each innings in the first Test, was caught at square-leg off a short delivery from paceman Rubel Hossain, while Gayle was well caught by wicket-keeper Mushfiqur Rahim off spinner Sohag Gazi.
Earlier, Bangladesh added 22 to their overnight score of 365-8.
Abul Hasan, who on Wednesday became only the second man in 135 years of Test cricket to score a debut hundred while batting at number 10, was last man out.
The 20-year-old left-hander hit 14 boundaries and three sixes during his 163-ball knock before being caught in the slips off a short Fidel Edwards delivery.
He fell just four short of equalling the highest ever individual score by a number 10 batsman set by Walter Read for England against Australia at The Oval in 1884.
Mohammad Mahmudullah was dismissed in the third over of the day when he gave Darren Sammy a return catch after scoring a solid 76.
He had helped Hasan add 184 runs for the ninth wicket to lift the home team from a precarious 193-8 on the first day.
Their partnership fell just 11 short of the world record ninth-wicket partnership by South African pair Mark Boucher and Pat Symcox against Pakistan in Johannesburg in 1998.
Mahmudullah hit nine boundaries during his almost three-hour stay.
Edwards was the pick of the bowlers with 6-90, his 12th five-wicket haul in Test matches. Sammy chipped in with 3-74.
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Abreu already displaying powerful bat, work ethic
Cuban first baseman in camp early to get jump start on rookie season
GLENDALE, Ariz. -- The man dubbed "oso" or "Yogi" by some of his White Sox teammates for his bear-like physical stature is coming out of hibernation.
Jose Abreu, whose nickname was announced by center fielder Adam Eaton on Tuesday morning, held court with the media for the first time during his first Spring Training at Camelback Ranch. But the reality of his situation is that the 6-foot-3, 255-pound first baseman hasn't been dormant since agreeing to terms with the White Sox on a six-year, $68 million deal.
Abreu arrived in Arizona from his Florida home during the first week of February, approximately 2 1/2 weeks before pitchers and catchers report on Thursday, to get situated and ready for Spring Training. His work ethic has been unparalleled, with Gordon Beckham joking that the big man hit for about four hours on Monday.
Standing even with his intense preparation is Abreu's consistent approach and plan for hitting. It's that thought process helping Abreu take the ball consistently to right-center that impresses Robin Ventura as much as the monstrous home run the right-handed slugger launched during batting practice on Tuesday against his manager.
"Right now, I'm thinking of preparing for the 28th, when the games start," said Abreu through White Sox coach and translator Lino Diaz. "I'm working on little things, being able to hit the ball the other way, the way I pull my hands through. I'm not concerned with hitting home runs at all. It's a process."
"It's professional. That's another one of those things we liked about him, numbers-wise and talent," said Ventura. "He has more of a professional approach for being a big guy, hitting the ball the other way, more aware of his pitch. That's stuff you like to see, the way they work, they go about it. He knows how to practice."
That practice isn't just limited to offense, where Abreu is being counted on for the greatest impact by the White Sox. According to Eaton, Abreu's quiet passion shows through in pretty much everything he has been doing.
If he doesn't do something right, Abreu goes after it again and again and learns from it.
"He really works his tail off," Eaton said.
"Expectations for me are clear, but I have to prepare," Abreu said. "That's all I control for now is preparation. That's what I'm doing right now."
Excitement builds among White Sox fans with every move Abreu makes, as they look forward to his first live BP session, his first Cactus League contest and then his Major League debut on March 31 at home against the Twins. Ventura wouldn't really commit when asked Tuesday about Abreu hitting cleanup or getting at least 500 at-bats, but those have to be two of the base goals for the young man from Cuba.
Fan and media attention serves as a source of motivation, according to Abreu. Ventura believes that his first baseman can handle such pressure, the sort of early and frequent attention that comes around great hitters who possess that special aura.
"You see that with guys even from other teams," said Ventura. "You would try to peak over at Edgar Martinez in the cage to see what he was doing. When you play the Yankees, you get in the cage when Don Mattingly is in there to see what he's doing and why. Hopefully, he has that. His practice habits and the things that he does, he has the potential to do that.
"For him, you let him just handle it. I think he's mature enough and good enough. That's part of coming here and that's the challenge for him of leaving a another country and getting the contract he got to go play. That's a fun challenge to have, and I think he has the personality and makeup to handle it just fine."
Although he has only talked by phone briefly to fellow Cuban success stories Yoenis Cespedes and Yasiel Puig, Abreu hopes to chat with both about their big league adjustment process during the course of Cactus League action. Abreu looks at their accomplishments more as another source of inspiration and not something he must match.
Ultimately, Abreu's consistent overall approach will help carry him through that adjustment period and through the expected slump or two in what the White Sox hope is a bear of a rookie season.
"I've seen quite a few guys that have had a professional approach. With him being as big as he is, it's stuff that's nice to see," Ventura said. "I know Frank [Thomas is] a Hall of Famer, but Frank was very good at moving it around and having a plan, even when he was in the cage.
"By no means am I saying he's in there with Frank. But you're looking at a guy that knows what he's doing and has a plan when he goes in there, instead of just swinging as hard as he can and hopefully he hits it."


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OverViewU-BASIC BLK YK KZK(4-8) - 5 LI2018-2019 KIŞ 2018-2019 KIŞ TRİKO KAZAK KIZ-ERKEK 4-8 YAS
Product Description
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The member companies shall contact with the "Customer Service Team" to get information. It depends on the country and distance.
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Your order is going to be seen as delivered, when the tracking number arrives from the cargo company.
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Do I Have A Problem With Your Products?
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VATICAN CITY – Pope Francis took a first big step in reforming the troubled Vatican bank on Saturday by tapping a trusted prelate to help oversee its management, in a sign he wants to know more about its activities.
Francis signed off on naming Monsignor Battista Ricca as interim prelate of the Institute for Religious Works.
It's a key job that has been left vacant since 2011: The prelate oversees the bank's activities, attends its board meetings and, critically, has access to all its documentation. The prelate reports to the commission of cardinals who run the bank and is currently headed by the Vatican No. 2. That gives Ricca a near-direct line to the pope, serving as a bridge between the bank's lay managers and board members and its cardinal leadership.
Ricca is currently director of the Vatican hotel where Francis lives and other Vatican-owned residential institutes for clergy.
Technically the appointment was made by the bank's five-member commission of cardinals, headed by Cardinal Tarcisio Bertone, Vatican secretary of state. But the Vatican statement announcing the appointment made clear Francis had approved it, an indication that it was something Francis either initiated himself or strongly supported.
The Vatican spokesman, the Rev. Federico Lombardi, said the interim nature of the appointment was a sign that Francis is still mulling how to reform the Vatican bureaucracy as a whole — one of the major priorities set out by the cardinals who elected him pope in March.
Right before resigning, Benedict XVI named German aristocrat and financier Ernst von Freyberg as IOR president, filling a vacancy that had been left open for nine months following the remarkable ouster of Italian banker Ettore Gotti Tedeschi for alleged incompetence. Von Freyberg has said the bank's main problem is its reputation, not any operational shortcomings.
The Council of Europe's Moneyval committee, however, says otherwise. The committee, which helps member countries comply with international norms to fight money laundering and terrorist financing, gave the Vatican bank several poor or failing grades in its inaugural evaluation last year.
While praising the Vatican as a whole for making progress quickly, Moneyval said the bank's rules for customer due diligence, wire transfers and suspicious transaction reporting were insufficient. It said the bank needed an independent supervisor and must conduct a thorough risk assessment to ensure that it knew its clients and the risks it faces.
Vatican officials have recently revealed that six such transactions were flagged last year and another seven so far in 2013.
But the customer checks are only now getting underway, even though the Vatican pledged to Moneyval that they would be completed by December 2012. Von Freyberg has said they would be completed by the end of July.
The Vatican must submit a progress report to Moneyval in November.
The Vatican opened itself to the Moneyval evaluation process after signing a new European Union monetary agreement in 2009. Its aim is to shed the bank's image as a secretive tax haven and improve its reputation in global financial circles following a series of scandals, including a money-laundering investigation launched by Rome prosecutors in 2010.
In an interview this week, von Freyberg said his aim was to make the bank's activities more transparent, by publishing its annual report online on Oct. 1. He has hired a leading firm in the fight against money laundering, Promontory Group, to go over the bank's client base, a top-notch international law firm to review the bank's legal framework, and a fancy German public relations agency to help revamp the bank's image.
"I cannot comment on the past," von Freyberg said. "I am here now to take things in hand and we are doing this with great effort."
He said he had some of his own ideas about bank reform, but that the cardinals were the top decision-makers and that the mission of the IOR remained the same.
The Vatican bank was founded in 1942 by Pope Pius XII to manage assets destined for religious or charitable works. Located in a tower just inside the gates of Vatican City, it also manages the pension system for the Vatican's thousands of employees.
The bank is not open to the public; its 19,000 clients include Holy See personnel, religious orders, prelates and diplomats accredited to the Holy See.
The Vatican bank's finances have long been shrouded in secrecy. Most famously, it was implicated in a scandal over the collapse of Italy's Banco Ambrosiano in the 1980s in one of Italy's largest fraud cases. Roberto Calvi, the head of Banco Ambrosiano, was found hanging from Blackfriars Bridge in London in 1982 in circumstances that remain mysterious.
Banco Ambrosiano collapsed following the disappearance of $1.3 billion in loans the bank had made to several dummy companies in Latin America. The Vatican had provided letters of credit for the loans.
While denying any wrongdoing, the Vatican bank agreed to pay $250 million to Ambrosiano's creditors.
In the 2010 money laundering case, Italian financial police seized euro23 million and Rome prosecutors placed the IOR's then-president, Gotti Tedeschi, and general director Paolo Cipriani under investigation for alleged violations of Italy's anti-money laundering norms in conducting a routine transaction from an IOR account at an Italian bank. The money was eventually unfrozen. The men technically remain under investigation but nearly three years on, haven't been charged.
But that isn't the only problem facing the IOR. Last year, under pressure from the Bank of Italy, JPMorgan closed its IOR accounts. And in December, again under pressure from the Bank of Italy, Deutsche Bank Italia halted its 15-year term providing electronic payment services to the Vatican, leaving the tiny city state cash-only. E-commerce operations only resumed at the end of May and still aren't fully operational, even though the Vatican announced in Februrary the problem had been resolved, The Associated Press reported earlier this week.
Follow Nicole Winfield at www.twitter.com/nwinfield


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Doctoral Thesis
Year of publication
- 2014 (1) (remove)
Document Type
- Doctoral Thesis (1) (remove)
- humane Zelllinien (1) (remove)
Proteomic characterization of host-pathogen interactions using human cell lines infected with Staphylococcus aureus HG001 as a model (2014)
Staphylococcus aureus is a commensal that colonizes the skin and mucosa of 20-30% of the human population without leading to symptoms of diseases. However, it is also the most important cause of nosocomial infections. Those range from minor skin infections to life-threatening diseases such as pneumonia, endocarditis or septicaemia. Development of strains with resistance against many antibiotics complicates the situation further. The variety of strains with their various properties is one reason why no successful vaccine has been introduced to the market, yet. Therefore, efficient strategies for prevention and therapy of these dangerous infections are urgently needed. To accomplish these goals, the understanding of molecular interactions between host and pathogen is indispensable. Within this dissertation, several internalization experiments were performed aiming to investigate the interaction of S. aureus HG001 and human cell lines upon infection on the protein level. In order to obtain sufficient amounts of proteins for comprehensive physiological interpretations, it is necessary to enrich bacteria, secreted bacterial proteins or infected host cells upon internalization. In the framework of this thesis, bacteria which continuously produce green fluorescent protein (GFP) were employed. With that it was possible to sort bacteria from lysed host cells by flow cytometry or to separate host cells carrying bacteria after contact from those which did not. Subsequently, the proteins were proteolytically digested and peptides were analyzed by mass spectrometry in a gel-free proteomics approach. To allow such analyses also for staphylococci which do not produce GFP, such as clinical isolates, an additional protocol was developed. Prior to the infection, bacteria were labeled with fluorescent or para-magnetic nanoparticles. Afterwards bacteria could be separated from host cell debris by fluorescence-based cell sorting or with the help of a strong magnet. In order to cover also important secreted virulence factors of S. aureus HG001, phagosomes and engulfed bacteria and secreted proteins were isolated from infected host cells. Further steps of protocol optimization included improved bacterial cell counting by fluorescence-based flow cytometry, enhanced data analysis by combination of different search algorithms, and comprehensive functional annotation of proteins of the applied strain by sequence comparison with other strains and organisms. First, the proteome adaptation of internalized S. aureus HG001 and the infected A549 host cells was investigated during the first hours of infection. It became clear, that the bacteria replicate inside the host during the first 6.5 h. After internalization the levels of bacterial enzymes involved in protein biosynthesis decreased. Furthermore, bacteria adapted their proteome to the harsh intracellular conditions such as oxygen limitation, cell wall stress, host defense in terms of oxidative stress, and nutrient limitation. After contact to S. aureus HG001, A549 cells produced increased amounts of cytokines (e.g. IL-8, IFN-Îł) in comparison to non-treated A549 cells. In addition, activation of the immunoproteasome and hints of early apoptosis activity were observed. Afterwards, the response of S. aureus HG001 to internalization by A549, S9 or HEK 293 cells was compared on the proteome level. It was obvious, that the adaptation to stress and the reduced protein synthesis are conserved mechanisms. Host dependent differences were detected especially in the energy metabolism and the synthesis of some amino acids. Additionally, bacteria showed different intracellular replication patterns depending on the host cell line. A higher percentage of extracellular bacterial proteins was found in isolated phagosomes compared to the sorted samples. Selected low abundant virulence factors could be quantified at two points in time after infection with the help of the sensitive single reaction monitoring (SRM) method. Further, a heterogeneous mixture of several phagosomal maturation steps was present during the first 6.5 h after infection. Finally, the gel-free proteome analyses could be applied to investigate Bordetella pertussis, the cause of whooping cough, during iron limitation and after internalization, and the results were compared to the S. aureus HG001 data.


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MYSTIC PROPHECY Preparing To Enter Studio
Greek/German heavy metallers MYSTIC PROPHECY are preparing to enter the studio to begin recording their eighth album for an early 2013 release. The recording process will once again take place at the Prophecy Music Factory Studios in Germany, with singer Roberto Dimitri Liapakis (SUICIDAL ANGELS, VALLEY'S EVE, INSIDEAD) in the producer's chair. The set will also contain a bonus live DVD from MYSTIC PROPHECY's ProgPower USA performance, and will be made available in various limited-edition formats.
Commented Liapakis: "After a successful tour last spring, summer festivals and an amazing trip to ProgPower USA, the time has come for us to enter the studio for our next album. The band is even stronger and united, with more versatility and depth in our new compositions, and with even more power, we couldn't imagine it any better."
MYSTIC PROPHECY is already scheduling its 2013 concerts.
The band's seventh album, "Ravenlord", was released in November 2011 via Massacre Records.


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Clinton: Better rules needed on spying
WASHINGTON (AP) — Bill Clinton is calling for clarity in how countries gather intelligence.
And when it comes to secretly monitoring the telephone conversations or emails of world leaders, the former president says American agencies might have spied on leaders his administration thought were engaging in hostile acts against the U.S. He says his administration didn't have the ability to do much of what's currently being done.
Clinton commented Tuesday during an interview with the Fusion television network.
Documents leaked this summer by former National Security Agency contractor Edward Snowden exposed a massive U.S. surveillance operation that covered telephone records, email traffic and the communications of U.S. allies, including Brazil, Germany and Mexico.
A report by a panel of advisers President Barack Obama chose to review NSA programs is expected this month.


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Staff regulations - common pattern
(1) At its 3rd and 4th sessions (October 1948 and January 1949: CO-ORDINATION-PREP/87 and 98) CCAQ discussed certain questions affecting the development of a common pattern of staff regulations. At the 9th session (July 1950: CC/A.9/CO-ORDINATION/R.83) it discussed draft common staff regulations. Subject to some changes, the Committee agreed to submit this to ACC, it being understood that the agreement did not affect the constitutional position relating to the competence of each agency to approve and amend its own staff regulations.


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Recommended Grades: K-2
When Nicki drops his mitten in the snow and continues to play without realizing it. One by one, woodland animals find the mitten and crawl in.
Lesson Idea:
Making Predictions: Written in her unique style, Jan Brett provides a book that not only tells a story through text, but also through the pictures. Read aloud The Mitten and point out the pictures to students. Ask students to use the pictures to make predictions about what they think will happen as you read.
©2012 by Dawn Little for Picture This! Teaching with Picture Books. All Amazon links are affiliate links and may result in my receiving a small commission. This is at no additional cost to you.


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Gateway DLMS EMH by RS232
Gateway for data reading from energy meters with DLMS protocol and for the conversion in Modbus protocol, both TCP and RTU.
Gateway for the fast reading of data from meters with DLMS protocol.
Instantenous conversion of reading in Modbus TCP or RTU.
The DLMS protocol (Device Language Message Specification) is used in the context of the meters and in particular of energy meters for the reading of operating data. The reference standard is IEC 62056.
It si based on services that allows to read the objects, definided OBIS,into which are mapped the operating values of the meters according to standard profiles.
Marcom provides a DLMS-MODBUS gateway through which is possible to read by communicating with MODBUS RTU or MODBUS TCP protocol, data provided by the meter equipped with DLMS protocol.
The meters actually encoded are the follow:
- Iskraemeco
- Landis+Gyr
- EMH meter
- Actaris SL7000
- Elster A1700
- Elster A1500
- for further meters is required phone number for test.
Version available for connection via optical probe (IEC 1107).
The gateway presents:
|Link / Connection
|Power supply
|Signaling LED on the front for the diagnostics of the communication
|Modbus registers for the setting of the serial number of the meter.
Possibility to read multiple meters
Possibility on demand to provide frameworks of field complete of cables and the accessories for the functioning.Look Photo.
For more information visit the WIKIpage


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Winner Foods Limited has been operating since January 1993 and is based in North London, U.K. Under the expertise and experience of its seven founders, Winner Foods Ltd. has not only established itself in the local market as a hygienic and reputable manufacturer of fresh, frozen and dried noodles but it has also developed into one of the five largest noodle manufacturers in England. The products of Winner Foods Ltd are GM free and comply with the respective EC regulation.
The company manufactures traditional style Chinese pastry, Chinese and Asian fresh & dried noodle in both catering & retail sizes, in which dried noodles include Chop Suey, Extra Fine & Broad noodles. Our daily production ranges from traditional fresh Wanton pastry, Siew Mai Pastry, Dumpling pastry, Shanghai pastry, Fried pastry, Gyoza pastry, fresh Wanton noodles, Egg noodles, Shanghai noodles, Crispy Egg noodles and Japanese style Ramen to various fresh and frozen pastry & noodles according to customers' specifications.
We command high standards in the quality of our noodles and pastry; this is achieved solely through years of experience & the use of fine product ingredients together with the aid of modern noodle-making methods. Since its incorporation, the company has experienced steady growth. We supply numerous medium sized Chinese wholesalers, supermarkets, restaurants & Take-Away marketed either under the company's own "WINNER FOODS BRAND", "EARTH BRAND" or customers' labels. Our products are also exported to Europe including Netherlands, France, Belgium, and Spain.
To ensure its superior standing in the marketplace, all products are manufactured and maintained under stringent quality control systems, from production to delivery to business customers. All personnel in the hierarchy are not only experienced but undergo regular relevant training programs to keep us all in touch with the latest manufacturing methods and to learn business and management best practices. Emphasis on research & development is another key factor in ensuring that we are always ahead of our competitors and our customers are being well served.


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|Previous Page | Table of Contents | Index | Next Page
Chapter 4
You may want to see:
Allocation of Interest(p11)
The easiest way to trace disbursements to specific uses is to keep the proceeds of a particular loan separate from any other funds.
Secured loan.(p11)
If the property that secures the loan is your home, you generally do not allocate the loan proceeds or the related interest. The interest is usually deductible as qualified home mortgage interest, regardless of how the loan proceeds are used. For more information, see Publication 936.
Allocation period.(p11)
Proceeds not disbursed to borrower.(p11)
Proceeds deposited in borrower's account.(p11)
|Order of funds spent.(p11)
|January 9
|$500 proceeds of Loan A and $1,000 unborrowed funds deposited
|January 14
|$500 proceeds of Loan B
|February 19
|$800 used for personal purposes
|February 27
|$700 used for passive activity
|June 19
|$1,000 proceeds of Loan C
|November 20
|$800 used for an investment
|December 18
|$600 used for personal purposes
|Payments from checking accounts.(p12)
|Amounts paid within 30 days.(p12)
|Optional method for determining date of reallocation.(p12)
|Interest on a segregated account.(p12)
Loan repayment.(p12)
Line of credit (continuous borrowings).(p12)
Loan refinancing.(p12)
Debt-financed distribution.(p12)
|How to report.(p12)
|Previous Page | Table of Contents | Top of Page | Index | Next Page


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Steadman Clinic, Steadman Philippon Research Institute name new CEO
VAIL — Vail's Steadman Clinic and Steadman Philippon Research Institute announced on Tuesday that former Walmart executive and institute board member Tom Mars was named CEO of both organizations.
Mars will guide the direction of both the prestigious orthopedic clinic and the internationally recognized research branch of the organization — the clinic and institute previously had separate CEOs. In the newly created position, Mars partially steps into the shoes that would have been filled by former president and CEO of the Steadman Philippon Research Institute, Mike Egan. Egan died in a bike accident in 2011.
Lyon Steadman, who was CEO of the Steadman Clinic, will continue with his normal executive managing role of day-to-day operations at the clinic.
Unified vision
Clinic and institute leaders hope Mars will be able to give the two branches a unified vision for success in the future, which includes building the clinic's reputation on a national and international level, bringing more funding to the research institute and using his network to create valuable partnerships for the company.
The research institute is a leader in orthopedic research and pioneering evidence-based procedures, most recently recognized in Europe for ground-breaking research on labral reconstruction in the hip. Mars said he will help the institute continue producing such advances, as well as establish the Steadman Clinic as a household name that would be a first choice for anyone looking for orthopedic surgery options.
Both partner-founder and surgeon Richard Steadman and managing partner-surgeon Marc Philippon said they felt Mars' experience leading Walmart, as well as in management positions in other careers, will help the clinic and institute reach its full potential for keeping people active.
"We felt there was a leadership that was needed that we just didn't have," said Steadman of bringing Mars on board. "There was a lot of hesitancy in filling (Egan's) job because it was a job he should have had. Then along came a candidate that we just couldn't pass up."
Mars spent more than a decade with Walmart, the world's largest retailer. Before retiring in March, Mars served as executive vice president and chief administrative officer for Walmarts in the U.S. He was responsible for real estate strategy and operations, human resources, asset protection and financial services in the United States. He also led the company's employment practices, labor relations and compliance departments. Previous to that career, Mars also was director of the Arkansas State Police and practiced law.
Former patient
He came upon the Steadman Clinic as a patient — he was in need of knee surgery after years of running and other athletics. A local surgeon in Arkansas suggested he look outside the area to get the procedure done, and Mars quickly came upon the Steadman Clinic. Originally expecting a tough procedure and about six weeks on crutches to repair a meniscus and relieve arthritis, Mars said he was impressed with the care he received at the Steadman Clinic. Also, he was shocked that he was on a spin bike the day after the surgery, out of the hospital within a couple of days and walking without crutches less than three weeks post-operation.
He joined the research institute board about three years ago, and now said he is excited to move his family to Vail and help lead both the nonprofit institute and the clinic.
"Any seasoned business executive who's familiar with the Steadman Clinic and the Steadman Philippon Research Institute would jump at the opportunity to lead these great organizations," Mars said. "Given my perspective as a SPRI board member and a former patient of the Steadman Clinic, it's easy to see the potential for these organizations to have an even greater influence on the advancement of sports medicine. My family and I are looking forward to living in the Vail Valley and being part of the community."
Assistant Managing Editor Melanie Wong can be reached at 970-748-2927 and firstname.lastname@example.com.
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Masks up! Colorado ski resorts are moving ahead as state, counties and businesses restrict access
VAIL — The lift operator in the maze at Vail Village's Gondola One tilts his head back and hollers: "Masks up please!"


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When I was in high school, I used to have a recurring dream that it was the night before the apocalypse and I was somewhere with a guy I liked. We weren't married, so the dream always came back to a debate over how to spend my last night alive. Would I obey God and die a virgin or would I give in and finally have sex, albeit in sin?
I don't tend to think of myself as someone who is all that angry, but when I get the most upset, it is almost always because of some circumstance or person that's kept me from getting my way. And as those dreams portended, following God has frequently meant not getting my way when it comes to sex.
When I was in my 20s and would get mad about being chaste, it always hinged on this notion that I was missing out on a lot of great sex. But the older I get, the more I see that as a lie. In every situation where I could have had sex, it would have been with a man I later got over. And if you had sat me down and asked about other parts of my life, I probably wouldn't have been as eager to share them with him.
But that's what sex with someone I've not committed to sharing my life with is. If I wouldn't give him access to my bank account or power of attorney, maybe not even my journals or my house plants, why would I share my body with him? Should that be the least guarded part of my life?
So more and more, when I hit those restless times of the month, when I almost need to put Tabasco on my hands the way my parents did when they were breaking us of thumb-sucking, I have to remind myself that I'm longing for something that isn't real; it's a fantasy. What I want is to share my body with a man who's completely committed to me, but that is not a relationship I have right now. The world where I could have instant, completely gratifying sex that leaves me without any hurt or negative consequences doesn't exist.
Coming to grips with reality is one thing that's helped me submit my body to God. But that's not enough. In Philippians, when Paul talks about Jesus enduring the cross, he doesn't say Jesus did that just out of firm resolve or something but that by fixing his eyes on the joy that was set before him, he endured the cross.
I honestly don't know how I've made it 33 years like this. It is certainly not for lack of wanting sex or trying to make myself available. But somehow, between God's sometimes-firm resistance to me getting my foolish way, and the hope that God's provision will be best, a fragile chastity has endured.
One thing that has kept me on this course is a very early experience of God's intervention in my love life not to thwart something, but to bring about a deep desire of mine, which I was certain I'd doomed. Through all the doubts and rages in the 14 years since then, the memory has remained: me out of control, God in control produced the most joyous moment in my life. You can't forget a thing like that.
And in the years since then, God's varied kindnesses have only accumulated. Time after time God's shown a very intimate knowledge of both my needs and the desires of my heart. I still don't know whether God's plan for my future will involve marriage, but a God who's been this good in so many relatively small things would not overlook a thing so big as my sexuality or fail to be just as gracious and loving in that, too.
And lately, I'm even starting to get hints of why I might have been single so long. As far as I was concerned, I should have gotten married pretty much as soon as I finished college, but that didn't happen. So I was single and I was single and then suddenly, in my mid-20s, I had this opportunity to write a memoir about my reluctant chastity. Well, OK, maybe there was a reason for my delayed marriage after all. But once the book came out, it seemed like there was no good reason to stay single any longer.
That was four years ago. For much of the time since, I've been frustrated that God was seemingly letting my fertility burn — and for no apparent good reason. But then last fall, I got an idea to organize a day to pray for the men who pay for sex: that they would turn from their ways and become the men they're capable of being. It initially seemed like just a small project, but I've realized that Pray for the Johns Day might be something important … and I don't think I could have done it if I had been married. So now that's two things I've had the chance to do, which it seems I needed to be single in order to do.
I still hope that God has a marriage in my future, and that I could even become a mother, but reconciling spirituality and sexuality continues to mean that I often don't get my own way. That can be really hard, even after all these years. But sometimes, when I remember what's happened other times when I was out of control, God in control, it even makes me a little excited to see what God might have in store for my body and soul.
Anna Broadway is a writer and editor living near San Francisco. The author of Sexless in the City: A Memoir of Reluctant Chastity, she is a regular contributor to the Her.meneutics blog and has also written for Books and Culture, Patheos, RejectApathy, Radiant and Beliefnet.
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Vanessa Redgrave, daughter Joely Richardson team in new film
Vanessa Redgrave and daughter Joely Richardson team up in new film of familiar story
LONDON -- She first saw the play as a child, when her famous father adapted it from a Henry James novella and played the male lead. Decades later, Vanessa Redgrave acted the role of Miss Tina on stage.
More time has passed, and now she is playing the forbidding grande dame Juliana Bordereau in a movie version of "The Aspern Papers" that opens Friday in the United States, this time with her daughter Joely Richardson cast in the younger woman's role.
"I've been through every version of it," says Redgrave, whose blue eyes still pierce. "My father was in it with two wonderful actresses, which I saw a number of times. Then I was in it much later as Miss Tina, and suddenly I get the chance to be this ferocious Bordereau, the old lady, which is kind of the full stretch of the bow, if you see what I mean."
Redgrave, at 81, still radiates the outspoken intelligence that has characterized her film and stage work, softening only when looking into the eyes of her daughter — "She's so beautiful," Redgrave coos — or cuddling her poodle-Pomeranian, Zep.
"It was heaven working with Joels," Redgrave says, pronouncing her daughter's nickname as Jules.
It is the fourth time the two have paired, a sequence that includes Redgrave joining her daughter on the popular TV series "Nip/Tuck" in a number of episodes, including one in which Redgrave sought a facelift from one of the two handsome young plastic surgeons at the heart of the show.
At the time, Richardson — one of the three stars — worried that her mother might not cope well with the demands of weekly television, including the need for quick memorization of dozens of pages of scripts.
Her mom thrived, of course, even if she's far better known for her dramatic work onstage.
For Richardson, working with her mother highlights what she calls "that Mom-Vanessa thing." It's what happens when your mother has been famous your entire life — and has set a standard in the profession you chose.
"It's so funny, 'cause obviously mom's mom to me, but when I'm talking about her in a professional capacity, I tend to go into calling her Vanessa," Richardson says. "When your mother's public and private, it's a two-name deal."
Working with her mother has been revelatory, says Richardson, who has also shared screen and stage time with Judi Dench, Glenn Close, Robert DeNiro and other greats.
"Sometimes I see her as Vanessa," says Richardson, 54. "Being on stage with her, it was like, oh my God, this is where it happens. It's in these moments, these magic moments, when she's truly more present than I've ever seen her be, probably, in real life. It's an extraordinary thing."
Redgrave is similarly impressed with her daughter's performance in "The Aspern Papers," which is set in Venice in the late 19th Century. Richardson plays Miss Tina, a quietly unhappy middle-aged woman frightened of her elderly aunt whose life is disrupted by the arrival of an American editor seeking the old woman's love letters from a fictional Romantic poet named Jeffrey Aspern.
"Suddenly, Joely becomes Miss Tina, right on the spot," Redgrave says of her daughter. "Looking into her eyes, I don't see Joely. I see Miss Tina. That's special, that's what she's about in her work, finding that depth of truth."
Redgrave is the matriarch of a venerable British acting dynasty that includes her late father Michael Redgrave; her late siblings Lynne and Corin Redgrave; and her children — Natasha Richardson, who died in a ski accident in 2009, Joely Richardson and writer and director Carlo Nero.
She recently worked with Nero on a documentary, "Sea Sorrow," a very personal look at the migrant crisis motivated in part by her belief that the lessons of World War II have been forgotten.
"People don't know the history of those times, and if they don't understand the history, they don't understand why it is so vital to support the international human rights laws. Today we have organizations based on those laws, but we have governments that refuse them," she says.
Redgrave has long worked on refugee causes with United Nations agencies, and Richardson is also active with agencies advocating for refuges.
They filmed "The Aspern Papers" — with Jonathan Rhys Meyers in the male lead — in Venice during the stifling summer of 2017.
Richardson worried that her mother would have trouble coping with the heat, and the hundreds of steps leading to the dilapidated palace where most scenes were filmed, but Redgrave saw the time there as a blessing.
"That's a treat," she says of the time in Venice. "T-R-E-A-T."


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Chances are you already know Static X. The bloke with the ludicrous barnet, the band with the obvious bland repetitive tunes and that are destined to be the support band for life. Well, I don't know what happened between 'Wisconsin Death Trip' and 'Machine' but the transition has been amazing. From the second the pulverising intro of 'Get to the Gone' to the final strains of 'A Dios Alma Perdida' this is Nu-metal brutality at it's finest, each track chugging along with all the finesse of a bulldozer but would you want it any other way?
It is impossible to put into words just how much Static X have progressed since their last effort. True enough, it's not the most original of sounds (think Ministry crossed with Slipknot) but it does have all the enthusiasm of a bull charging for El Matador's red cloth and twice the power. Both Static X and Spineshank seem to have recorded debut records that can only be described as piss poor and have come back with records that you would never imagine they could concoct within the time period of a million years let alone two or three. This could potentially be Wayne and the boys only problem, will the public forgive that cack debut and fork out there hard earned cash on their latest opus? They didn't for Santos' crew.
The production of this record also has to be congratulated, capturing every electronic sample and cranium crushing guitar attack at its fullest and creating a wall of sound so huge that it would even make Hadrian blush. But ultimately with a collection of tunes which include such beasts as hit-in-waiting 'Black and White' and the Pantera-like dynamics of 'Structural Defect', Static X really do deserve to prevail like the proverbial Phoenix from the flames. 'Get to the Gone' is as bone-fracturingly heavy an opening to an album as you would expect to hear and the likes of 'This is Not', while following a Nu-Metal blueprint seems to add a new layer of insanity and smash through the likes of Papa Roach as if they were the spice girls. This could be the appeal to Static, just as it is with Slipknot, while being very 'Nu' in it's roots there is a heaviness here that drags it beyond the likes of Linkin Park and the aforementioned Roach.
But after all is said and done, by the albums end you do feel like you've heard this track earlier on the record and when it comes to future releases you do wonder how far the Static quartet will be able to push the envelope, but for now this'll do them very nicely thank you.
8Terry Bezer's Score