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The Dark Archer will pay Starling City a visit on this week's Arrow, and considering John Barrowman's "well-dressed man" was revealed to be Malcolm Merlyn, the father of Tommy (Colin Donnell), it seems only likely that the DC Comics' famed dark archer - aka Merlyn - is one and the same as the new villain plaguing Oliver (Stephen Amell). So is Malcolm the famed Merlyn or is it his son? TVGuide.com turned to Barrowman to get the scoop:
Arrow Scoop: Oliver may find love with someone other than Laurel
I'm sure you knew this role was something more than just the "well-dressed man," but what was it exactly that attracted you to coming on Arrow? John Barrowman: I was in my house in Palm Springs and my partner and I were having a little bit of a break, and I received a telephone call via my agency in the States and they said they wanted to set me up with a call with the producers of this new show they're doing called Arrow on The CW. So I had a conversation with Andrew Kreisberg and a few other people, and they basically said, "We loved you on Torchwood. We loved what you've done on Doctor Who. We think you'd be great on this show." They explained the role to me, and the last thing they said was, "It's not a very big part at the moment, but we'd like to build it. We wonder if you'd be involved." I said to them right off the bat, "Guys, you've just spoken to me for 30 minutes. The passion you have in your voices about the show - and it's the same feeling I got when I did Torchwood and Doctor Who - and I firmly believe because of that that you're going to produce a great show, so you can count me on board.
I was flattered to be asked. How many times do we, as actors, get producers and people calling us to help create a role and a character on a major TV show? I was bowled over that I was asked, so of course I would jump at it. I'm glad I did because I'm loving doing it and I'm having a really great time. The cast is incredible, and Stephen is wonderful. It's funny because he says he looks up to me like the bigger brother in a sense that I've done all this sci-fi hero genre before. He asks me questions and I feel really privileged that he's turning to me for certain words of advice on fans and the whole comic book world because I've been a fanboy myself for a very long time. I'm having a ball.
We'll see the Dark Archer on this week's episode. Considering Merlyn knows a thing or two about shooting an arrow, how will he be involved? Barrowman: Well, you're assuming that all from the stuff that you've read from the comics, obviously. I can't confirm or deny any of that, but what I will say is that one thing with Malcolm that you will be learning in the future is that he will always reveal something that will surprise you. There's never going to be a dull moment with him in that aspect. I'm just really pleased at how the story line itself is going. There was a story first being built with Moira (Susanna Thompson) in a very small way, and then all of a sudden when you find out he's Tommy's father, it was a big reveal! So I'm looking forward to all that kind of stuff that is yet to come. That's the diplomatic answer. [Laughs]
Spartacus' Manu Bennett lands major Arrow role
He wants to protect the Tempest group, so he is out for blood when it comes to this vigilante. Barrowman: He is, but this is the way I look at it: When I play a villain - and this is the second or third time I've played a villain - I don't see him as being a villain really. I see him as also having a cause. It's funny because he goes about the cause in a way that's completely different than everybody else, but in his eyes, it seems right because he's protecting his interests. He's also trying to protect a greater good. In a way, the interests of Arrow, where he's trying to clean the city up, well, in Malcolm's eyes, he's trying to do the same thing, but in a way to protect himself at the same time.
What is his goal in going up against Arrow? Barrowman: If I told you what the goal was, I'd give you the spoiler for probably the rest of the season! To put it this way, Oliver has an objective and Oliver has a vendetta, yet, in Malcolm's eye, it's like he's using this vendetta to say he's cleaning up the city of the bad and wrong people on this list. Malcolm sees that these people are colleagues and co-workers, and not that all of them have been taken by Oliver, but some may have fallen by the wayside by Malcolm and Moira, which we know has happened to a couple and we've taken care of things. In a weird way, we're both going for the same thing.
Will Malcolm go face-to-face with Oliver and/or Arrow? Barrowman: Personally, I would love to see him go head-to-head with both Oliver and Arrow and also go head-to-head with Moira. As the story line with Moira is building, you can see that she's not becoming so frightened of Malcolm. She's standing up. You've got these very powerful people in very different ways. She's in a power position with her family and the stuff that her husband has left her, but Malcolm is in a powerful way with business and his colleagues and also with all the manipulation tactics that he has. I would love to see a real standoff between Oliver and Malcolm.
The big question now is: Who is really the famed Merlyn between Tommy and Malcolm? Did Malcolm cut Tommy off to teach him a lesson so he'll eventually come back into the fold? Is Tommy destined to follow in his father's footsteps? Barrowman: Seriously, you're asking such great stuff that I want to blurb out - and I know you want me to! What I can say is that Malcolm feels that Tommy is slightly a waste at the moment. Perhaps Malcolm is seeing something in Oliver that he would actually like to see in his own son. When Malcolm cuts off Tommy's trust fund and slaps him in the face, it's basically, in blunt terms, saying to him, "You are a f----up and you need to get your a-- in gear. I'm going to cut you off until you do; until you realize responsibility because you're just a waste of space." That's what he really would've loved to have said to him. [Laughs]
Fall TV Popularity Contest: And the winner is...
Considering Laurel (Katie Cassidy) is in between Oliver and Tommy, might Malcolm use her in his quest? Barrowman: If you go back to all that has happened from the beginning, you're right, Malcolm sees her as something standing in the way of things. He knows if a woman is in the way, that's a problem. The women are very powerful in the way that they do things and manipulate. Malcolm does meet her and he tries to be civil and nice, but it just doesn't turn out the way it's supposed to. Yes, Malcolm thinks she's in the way. But whether or not he has a confrontation with her or uses her against Oliver or Tommy, that hasn't come up into play yet.
Despite Oliver being cleared in public court, do you think Malcolm still suspects that Oliver has something to do with the vigilante or is actually the vigilante? Barrowman: Malcolm suspects, but again, cannot confirm. If Malcolm is suspecting things about anybody, he will always be very, very cautious of them.
Do you think Malcolm is the Dark Archer? Hit the comments!
Arrow airs Wednesdays at 8/7c on The CW.
View original Arrow: Is Malcolm Merlyn the Dark Archer? at TVGuide.com
Related Articles on TVGuide.com
Spartacus' Manu Bennett lands major Arrow role Fall TV Popularity Contest: And the winner is...Arrow Scoop: Oliver may find love with someone other than Laurel
Other Links From TVGuide.com
Susanna ThompsonJohn BarrowmanAndrew KreisbergKatie CassidyStephen AmellTorchwoodDoctor WhoArrowColin Donnell


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Pre-Application Conferences
Purpose of the Conference: The purpose of a pre-application conference is to advise and inform applicants of the procedural and substantive requirements of a land use review. A pre-application conference is required for all Type III and IV land use reviews prior to submittal of the application. Optional pre-application conferences are also available to discuss projects that entail a lower review process (Type I, II or IIx) or for projects that do not require a land use review (such as a building permit review).
Conference Scheduling: Conferences are generally scheduled 4-5 weeks in advance of the date of the meeting. Conferences are scheduled in the Development Services Center.
Conference Submittal Requirements
- Early Assistance Application
- Written project description
- Fee
- Site plans (2 copies, 8.5x11")
- Building Elevations (if appropriate) (2 copies)
Conference Agenda: You may view the Pre-Application Notices to see upcoming pre-application conferences. Conferences are posted 10 days in advance and removed at the end of the day of the conference.
Who Participates: City agencies, school districts, some state and federal agencies, and neighborhood associations within 1,000 feet of the site will be notified. Neighbors and other interested parties may attend pre-application conferences but are reminded that the primary purpose of the conference is to provide information to the applicant. Neighbors are asked to reserve questions and comments regarding the project for the applicant's meeting with the neighborhood association.
Where: Conferences are held at 1900 SW 4th Avenue on the 4th Floor. Please check in with the receptionist.
Pre-Application Conference Reports: Within three weeks of the day of the conference, a summary report is prepared and mailed to the applicant. Copies of the report are available to interested persons. A copy fee will be charged. Land Use Services Staff may be contacted at 503-823-7783 to request a copy of the report.
- Early Assistance Application - Complete this form to apply for a Pre-application Conference.
- Early Assistance Options - Summarizes different types of land use Early Assistance.

subset: commoncrawl


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FANTASY ISLAND: A|X Armani Exchange is going tropical for spring.
The men's and women's sportswear brand took over a private beach in Parrot Cay, Turks and Caicos, to shoot its spring advertising campaign, appropriately titled "Island Dwellers." The ads, which will break in February print magazines as well as online, in stores and outdoors, is designed to evoke "an intense mood of cool sensuality in a tropical paradise." The cast features Marlon Teixeira, Alejandra Alonso, Miguel Iglesias, Alexander Van Ballaer and Camila Queiroz. It was styled by David Vandewal of Art + Commerce and shot by photographer Matthew Scrivens of JET/MMS.
Tom Jarrold, creative director of JET/MMS, said the concept "focuses on the three A|X brand touch points — provocative imagery, youthful energy and relaxed sophistication. A|X is a sexy brand and these images take you to a fantasy world — an alluring escape that captures the Armani Exchange lifestyle."


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In today's Divisional Debacle, the Defense under Greg Manusky in the first half, gave up 207 yards of offense (105 rushing/102 passing) and two touchdowns. That said, they did manage a single INT on which the Offense actually managed to score a touchdown off of. They allowed 12 of 16 passes to be completed .
In the second half it was 107 yards given up (58 rushing//49 passing) a field goal and a touchdown. They traded their first half pick for a second half sack. However, Dallas completed all five of their pass attempts.
Don't read that thinking "Well it seems like they tightened up some in the 2nd half." They didn't. They simply had about half the plays in the second half. 30 plays in the First and 18 in the Second.
So far in two Divisional matchups, the Defense has faltered in the Second half. They start out like a house of fire for the first few drives until their opponents gradually make adjustments. This Defensive coaching staff fails make any adjustments, whether in game or at the very least at Halftime. They've given up over 30 points per game for a total of 63 points given up in two games. While the Bears are up next, the Pats await and they've put up over 70 points in two games. Yeah. Ok. They did shut out the Dolphins today which is looking like the NFL version of ... ahem... shooting fish in a barrel.
The frustrating thing is Manusky is the DC that the Front Office actively looked to replace during the off season without firing him. When you know they're looking to replace you, most people would make a concentrated effort to show an improvement. Yet Manusky's Defense still keeps acting like it's starring in Groundhog Day.
In his post game presser, when asked directly about if any coaching changes would be made, Gruden said "No, I think after two games – you're talking about playing two very good offensive football teams and two of the best offensive lines in pro football we just played back-to-back. That's no excuse whatsoever, but I don't think we need to hit the panic button yet. We just have to continue to focus on what we can do better to win. Get Jonathan [Allen] in here, get a couple of our corners back in here and let's go back and strap it up against Chicago [Bears] next week and see what happens."
Here's another frustrating thing. The defensive communication was an issue last season as well. Wasn't this supposed to have been worked on during OTA's and Training Camp? It's understandable that the rookies would still be on a learning curve, but NFL vets like Collins and DRC you'd think they would have down by the start of the season.
Gruden said they're a very talented group on Defense but that they weren't reaching them. When questioned as to why the coaching staff that has been in place for several years, wasn't reaching them, he defended the comment as them being a young defense. "We have some moving parts now. Landon Collins is a veteran guy but this is his first year, [Montez] Sweat's in his first year, [Cole] Holcomb, it's his first year, [Jon] Bostic is in his first year. We're playing Dominique [Rodgers-Cromartie] at corner and this is Jimmy Moreland's first year, so it's not like we are the most experienced group. We feel like were very talented, but we`re still fighting through somethings. There are a lot of things to look forward to, without a doubt, but we do have to play better and strap it up and get back to work."
- 5
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Local voters join other Vermont towns in passing anti-tar sands resolutions
Voters in Fayston, Warren, Waitsfield and Moretown joined voters throughout Vermont in passing an anti-tar sands oil resolution – in most local towns it was passed by a voice vote with little discussion.
In annual town meetings across the state, voters overwhelmingly voted in support of an anti-tar sands warning on their town ballot. Towns that passed the resolution include Bennington, Burlington, Cabot, Calais, Charlotte, Chittenden, Cornwall, Craftsbury, East Montpelier, Fayston, Grand Isle, Greensboro, Hinesburg, Marshfield, Middlebury, Middlesex, Montgomery, Montpelier, Moretown, Plainfield, Putney, Randolph, Ripton, Starksboro, Waitsfield, Walden, Warren, Woodbury and Worcester. No towns in the state voted against the resolution.
Specifically, voters indicated that they did not want tar sands oil or its derivatives from the oil fields of Alberta, Canada, transported through the Northeast Kingdom of Vermont.


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Last night's Suns-Spurs game got off to a unique start, as Steve Nash fell to the floor after being checked by a San Antonio defender, looked up at the referee to complain about the no-call, and simultaneously passed the ball to Marcin Gortat, who attempted a three-pointer. If there's any play that might represent Nash's career in a nutshell, it might be this one. (The Spurs won 107-100, led by "old man" Tim Duncan's 26 points.) [FS Arizona]
More from Deadspin


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Are you looking for a simple but stunning idea for your reception? Try a glamorous Champagne tower.
Champagne Tower How-To
1. Start with a firm, solid base for your tower (a separate table is best, with spillage tray at the base or underneath to catch any overflow.)
2. Always use coupe Champagne glasses (retro rounded saucer cups), not flutes. All of the coupe glasses in the tower should be identical. Most party rental places will have coupe glasses on hand for weddings.
3. The tower is essentially made up of successively smaller layers of squares. For example, if the bottom layer is 10 glasses by 10 glasses, the layer above that would be nine by nine, the layer above that eight by eight, and so on.
4. Make sure each glass touches the surrounding glasses. When done right, you'll see a diamond-shaped gap between each glass.
5. When building the next layer, center the stem of the glass over the diamond openings that were created by the layer below. Gingerly fill in the layer with glasses.
6. Repeat this assembly process until there is a single coupe glass on top.
7. Once fully assembled, begin slowly pouring Champagne from the the top glass and it will trickle downward. Larger-size Champagne bottles or magnums work best here.
8. If you're using the tower for decorative purposes only, assemble and fill with Champagne before the celebration. Then have trays filled with fresh Champagne at the base or passed to your guests.
Friday, September 12, 2008
~Champagne Tower
Posted by Wallflower Diaries at 6:53 PM
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High blood pressure, also known as hypertension, is one of the leading risk factors behind strokes, heart failure, aneurysms, and other deadly serious medical conditions. But here's the weird thing about hypertension: we don't actually know what causes it.
That may sound like a strange thing to say - surely, high blood pressure is the result of poor diet, or perhaps a genetic predisposition? And yes, both lifestyle choices and genetics have been shown to be correlated with hypertension, but they don't actually cause the condition. In 95% of all cases of hypertension - a category known as essential hypertension - there is no medically recognized cause at all.
Top image: Lisa F. Young/Shutterstock.
That may be about to change, thanks to researchers at the cardiology center of Beijing Chaoyang Hospital. They report the first conclusive evidence of a link between the human cytomegalovirus (HCMV) and essential hypertension. HCMV is a common virus that infects most people at some point in their lives, but it often remains completely dormant, and so shows no symptoms.
But when the virus does become activated, it can then cause high blood pressure, a condition exacerbated by all those genetic and lifestyle factors. This knowledge could have a huge impact on the fight against controlling hypertension, and by extension working to prevent strokes, serious heart conditions, and other deadly diseases. If we can create a vaccine for HCMV, it could radically cut down on the incidence of essential hypertension.
Researcher Yang Xinchun explains:
"If we can get conclusive evidence of the relationship, we can get better medical vaccines and remedies for hypertension. It is the first time someone managed to find this relationship...so we need to undergo more tests with a wider scope of patients."
The researchers stressed that a vaccine is still a long ways off, so it's still crucially important for those with hypertension or at risk of the condition to control the other risk factors. Since we can't change our genetics either, that pretty much comes down to altering diet and lifestyle to help control one's blood pressure.


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A 16-year-old boy was arrested on suspicion of inciting a riot in connection with a series of robberies and acts of vandalism carried out earlier this month by what authorities described as a violent "flash mob."
The boy, arrested Monday on the misdemeanor charge, is accused of using social media to organize the July 16 gathering of more than 30 people, some of whom stole cell phones and other items during a rampage on the Walk of Fame. Nine other teens were charged earlier this month in the series of robberies.
The 16-year-old also is being investigated in connection with crimes committed after a peaceful prayer vigil -- organized in response to the George Zimmerman trial verdict -- one day earlier in the Crenshaw area, police said. Officers issued an order to disperse after a violent splinter group broke off from the vigil participants, police said.
"It's unacceptable what happened in Southwest and Hollywood," said LAPD Deputy Chief Kirk Albanese. "A great deal of work has occurred in terms of social media and will continue to occur, so that we can understand what occurred out there as thoroughly as we possibly can.''
The nine individuals -- six males and three females, ages 16 and 15 -- arrested in the Hollywood case were charged with robbery for their roles in the wave of violence that began near Cahuenga Boulevard and spread along the Walk of Fame toward Hollywood and Highland. Cell phones, a wallet and a skateboard were stolen, and storeowners reported acts of vandalism.
Local news from across Southern California
The subjects pleaded not guilty July 19. Four were released to their parents and five remained detained Tuesday.
They are scheduled to return to court next month.
Walk of Fame visitors, store employees and police said a group of about 30 individuals knocked over pedestrians and signs as they stolen phones and other items. One store employee told NBC4 they "grabbed as much as they could" from his Hollywood Boulevard store.
About $1,700 worth of property and cash was stolen, according to the Los Angeles Police Department. Property damage totaled $300, police said at a Wednesday news conference.
Police also released a business surveillance image (right) of a subject wanted in connection with a robbery at Skooby's Hot Dogs during the July 16 rampage. The individual took money from a tip jar at the restaurant in the 6600 block of Hollywood Boulevard.
The Walk of Fame in Hollywood was the site of at least two other attacks in the last three months, including a fatal stabbing.
A woman was stabbed to death June 18 near Hollywood Boulevard and Highland Avenue after she refused to pay a homeless man for taking a photo of his sign. One of three men arrested in the case faces a murder charge.
In May, a transgender woman was attacked by at least four men on Hollywood Boulevard. The group kicked the victim on the ground before running away on the Walk of Fame, police said.
One man was arrested in that attack.
More Southern California Stories:
- 2 Hospitalized in Officer-Involved Car Crash
- Flock of Seagulls' Stolen Van Is Found Empty
- Watch Live: Today in LA
- Fuel Contaminates Carson Neighborhood
- Boy Meets Rescuers After Cardiac Arrest
- Police Seek Suspect in Deadly Hit-and-Run
- Report of Gunfire Locks Down Hollywood Block
- Record-Breaking Shoe Collector Killed in Menifee


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Woman falls asleep and drives into oncoming car
A 23-YEAR-OLD woman is lucky she didn't kill anybody when she fell asleep behind the wheel of her car.
That was the stern warning Judge Brendan Butler offered Melody Chi-Kwun Cheung in the Bundaberg District Court.
Cheung was charged with dangerous operation of a vehicle causing grievous bodily harm.
Crown prosecutor Christopher Cook said on June 9, 2016, Cheung, then 21, was driving from Gin Gin to Bundaberg along Bundaberg-Gin Gin Rd between 2pm and 3pm when she fell asleep briefly and veered into the opposing lane directly into a car driven by Raymond Fredrick Stevens in a head-on smash.
Mr Stevens' wife was in the passenger seat.
The court heard how Mr Stevens, 75, suffered serious injuries, which have left him with a disability.
Defence barrister Eoin Mac Giolla Ri said leading up to the crash, Cheung, an occupational therapist, had realised she was feeling tired.
Cheung stopped off at a Gin Gin coffee shop en route to Bundaberg.
"She acknowledges it was dangerous for her to keep driving," Mr Mac Giolla Ri said.
Mr Mac Giolla Ri said Cheung was not "burning the midnight oil" and her lifestyle was not depriving her of sleep.
"She's going from place to place doing good," he said.
Cheung wrote a letter to the victim, which the prosecutor had passed onto the victim's daughter, who was sitting in the courtroom.
Mr Cook submitted three victim impact statements as evidence, which Cheung elected not to read to stay emotionally stable during court proceedings.
Judge Butler said the fact Cheung had swerved into the wrong lane twice due to sleepiness before the crash and yet kept driving needed to be addressed as the consequences could have been much worse.
"You're fortunate you're not before this court having killed a person," he said.
Judge Butler said her actions had changed Mr and Mrs Stevens' lives forever.
"That's going to be with him for the rest of his life and makes his life much more difficult physically," Judge Butler said.
"I urge you to read the victim impact statements."
Cheung was sentenced to 18 months prison, wholly suspended for two years and cannot hold a licence for two years.


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SilverWorks Studio & Gallery is a working silversmith studio and includes an ongoing exhibition, as well as sales, of the work of artist-in-residence Blair Anderson.
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Mauro Vinicius da Silva at the 2013 IAAF World Championships
"Ola amigos! – Hello my friends!
"It's been a long time!
"Thanks for all the good wishes I received for the World Championships in Moscow. The event turned out to be a great experience for all my team. I was expecting more but I was pleased with both my performance (8.24m) and my fifth place.
"I struggled a bit during the qualifying round, where I had several problems. I could only advance to the final with the 11th best performance (7.92m).
"Those technical issues appeared again in the final, mostly in the first two jumps, which I fouled. So, I was really only left with four attempts, but I still did well: 8.09, 8.05, 8.23 and 8.24.
"However, it was rather bitter-sweet as an 8.29m jump was good enough for a silver medal and 8.27m for the bronze. It was a great event and Menkov (who jumped 8.56m for the gold medal) was simply in a different class.
"He put up a wonderful display and delivered one of the best moments of the World Championships for the home crowd.
"As for myself, I learned many lessons in Moscow. The most valuable one, perhaps, was the maturity and experience I gained from such a high quality competition.
"Despite being the 2012 World indoor champion, I haven't been at many of these events in my career. I'm still learning, that's the most important thing that I took away from my first World outdoor championship. It was another lesson – an important one.
"Although I was in great shape, I decided – along with my coach, 'Tide', and my physical therapist, Ricardo – to end the season after Moscow. My knees were feeling the pressure of lots of technical workouts, and we decided not to risk things. I know that the end-of-season meets are very profitable, but we try to think about long term.
"So, I came back home and started to rest, focusing on the 2014 season, which will have two goals: the World Indoor Championships and the Diamond League meetings in the second part of the year.
"Yet, next year will be taken as another step towards the major goal that we have, which is the 2016 Olympic Games in Rio de Janeiro.
"As I said before, I'm still a 'student' at major competitions. Going to Sopot 2014 as the defending World champion will be a great honour. I know I will be adding unnecessary pressure to myself if I head over there with the goal of repeating the title. I would obviously love that, but I just want to do well; being in the podium will be a great achievement for me.
"Training is going very well. We are still in the loading phase, just working on general conditioning and strength. Basically, I'm just starting putting the base together.
"In a couple of weeks we will move to the technical phase, were we will try to correct some aspects of the take-off and the landing. We haven't done any major tests, however 'Tide' is happy with my form and believes I'm in a good place, comparing to previous years.
"So far I have been confirmed for the indoor meet in Birmingham, in February. Before that we may jump outdoors a couple of times in São Paulo, to get ready for the winter season. The goal is to have three or four meets before Sopot."
"The rest of my life is great. At this part of the year, the end of spring in the southern hemisphere, I love to spend time at my little 'chacra' (ranch) in Sao Jose do Rio Preto. I also spent my vacation there. It's a place where I can relax and enjoy my free time.
"Since I travel for a big part of the year, I decided not to go anywhere. Maybe next year I will go to a beach for my holidays. However, my vacations were great and got me ready for another challenging season.
"We will spend the end-of-year holidays here as well, and also my birthday, which is 26 December! It will be a double celebration! It's great to have all my family and my girlfriend around at those times.
"Now, 2013 is almost over. Before it ends I will have the honour of receiving an award given by the Brazilian National Olympic Committee, which recognizes the best track and field athlete of the year. It's my first award and I hope it's not the last one!
Thanks to all of you who have followed this diary! It is a great feeling to be able to share my experiences with you. Thank you!
"Abraços (hugs) and best wishes for the New Year!
"Mauro Vinicius (Duda)"


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Showing 30 results
12th-century miscellany of Latin textsManuscript
The oldest surviving copy of the History of the Britons (Historia Brittonum) is found in a miscellany of late Antique an...
Anselm of Canterbury's theological treatisesManuscript
This composite volume, consisting of two originally separate booklets, contains seven of Anselm's thirteen scholarly tre...
Baudri of Bourgueil, History of JerusalemManuscript
The Historia Hierosolimitana (History of Jerusalem) is one of the most sophisticated accounts of the First Crusade (1095...
Boethius, De institutione arithmeticaManuscript
Written by the sixth-century Roman philosopher Boethius, De institutione arithmetica (On Arithmetic) was the principal m...
Cartulary of Reading AbbeyManuscript
The 12th-century Cartulary of Reading Abbey gives a list of works held at the medieval libraries at Reading Abbey and Le...
Collection of medieval chroniclesManuscript
Ralph de Diceto, Dean of St Paul's Cathedral from c. 1180 to c. 1199, wrote two historical chronicles, the Abbreviated C...
Computus collection including Byrhtferth of Ramsey...Manuscript
The Enchiridion (Handbook) by Byrhtferth of Ramsey Abbey (fl. c. 986–c. 1016) is a commentary on the computus, covering ...
Constantine the African, De MelancholiaManuscript
A treatise on melancholy by Constantine the African (d. 1098) is inserted into a collection of popular historical and ph...
Continental copy of Geoffrey of Monmouth's History...Manuscript
The History of the Kings of Britain presents a legendary account of the history of Britain composed by the 12th-century...
English collection of medical treatisesManuscript
Medical compilations in the 12th century tended to be reference volumes, consisting of a variety of important medical tr...
English copy of Bede's Commentary on the Gospel of...Manuscript
The Venerable Bede (b. c. 673, d. 735), whose greatest work was the Ecclesiastical History of the English People, also w...
English copy of St Augustine's De Trinitate from S...Manuscript
St Augustine's treatise on the Trinity was one of his most influential works. It concerns Christian theology and doctrin...
French illustrated copy of Gratian's DecretumManuscript
The Decretum, meaning a series of decrees, was the first of six volumes of the laws of the Church, known as canon law. S...
French Psalter composed in verseManuscript
The Book of Psalms was translated into French in the first half of the twelfth century. It became one of the most popula...
Geoffrey of Ufford's miscellaneous compilation of...Manuscript
A unique compilation of Latin moral, grammatical and historical treatises was collected by Geoffrey of Ufford in the 12t...


text:
Forgiveness is the highest and most difficult of all moral lesson.
- Joseph Jacobs
The people who try to do something and fail are infinitely better than those who try to do nothing and succeed.
- Lloyd James
We can only teach that which we are.
- Jean Jaurès
When a man mints coins - they are all alike, but when God mints people, each of them is uniquely different even though they all come from the same mold.
- Jewish Saying
It's OK to mess up. You should give yourself a break.
- Billy Joel
Yesterday is not ours to recover, but tomorrow is ours to win or lose.
- Lyndon Baines Johnson
Experience is that marvelous thing that enables you to recognize a mistake when you make it again.
- Franklin P. Jones
Problems are only opportunities in work clothes.
- Henry J. Kaiser
Wisdom is the reward for a lifetime of listening... when you'd have preferred to talk.
- D.J. Kaufman
Don't be angry that you cannot make others as you wish them to be, because you cannot make yourself as you wish to be.
Sunday, August 26, 2012
Monday quotes
Posted by Fireman John at 1:46 PM 0 comments
Friday, August 24, 2012
celebrity update
weekly celeb substance abuse news
from About.com/Alcoholism;
Armstrong to Be Stripped of Tour Titles
Cyclist icon Lance Armstrong will be stripped of his seven Tour de France titles and banned from the sport for life after he decided not to fight continued drug allegations by the USADA. Armstrong, who continues to deny any use or trafficking of prohibited drug, said he refused to participate in the "unconstitutional witch hunt" any longer.
Rodney King Death Ruled Accidental
The death of Rodney King by drowning in his own swimming pool has been ruled accidental, but the medical examiner said King had enough drugs and alcohol in his system to produce a "state of delirium." Toxicology reports showed King had PCP, cocaine and marijuana in his blood stream as well as a blood-alcohol level of 0.06.
Former Ambassador Ryan Crocker Arrested in DUI
Former U.S. diplomat Ryan Crocker has been charged with drunk driving and hit-and-run offenses after his 2009 Ford Mustang struck another vehicle. The former ambassador's blood-alcohol level was not recorded on the arresting documents.
'Zanny the Nanny' Busted on Alcohol Charge
The woman suing Casey Anthony because she has the same name as the fictitious nanny Anthony claimed kidnapped her 2-year-old daughter has been arrested on alcohol related charges. Zenaida Gonzalez was arrested and jailed on charges of giving alcohol to a minor.
Joey Kovar's Death Due to Overdose?
"Real World: Hollywood" star Joey Kovar, who was found dead at age 29 in a woman's Illinois apartment, may have died as a result of an accidental overdose of drugs and alcohol. Investigators believe the MTV star died from a combination of Viagra, alcohol and cocaine.
'Honey Badger' Checks Himself Into Rehab
Rather than transfer to a lower division school so that he can play college football this season, Tyrann "Honey Badger" Mathieu is going to remain at LSU and enter a drug treatment program. He was cut from the LSU football team after failing multiple drug tests.
Cat Cora Avoids Jail Time in DUI Case
Food Network star Cat Cora avoided a driving while intoxicated charge and jail time by pleading no contest to driving with a blood-alcohol level of 0.08 or higher. She was sentenced to three years probation and nine months of DUI school, and paid $2,386 in fines.
Posted by Fireman John at 10:09 AM 0 comments
Tuesday, August 21, 2012
quotes for today
Imagination is the highest kite one can fly.
- Lauren Bacall
To the timid soul, nothing is possible.
- John Bach
Every problem has a gift for you in its hands.
- Richard Bach
One must always maintain one's connection to the past and yet ceaselessly pull away from it.
- Gaston Bachelard
You don't get to choose how you're going to die. Or when. You can only decide how you're going to live. Now.
- Joan Baez
It is good to be without vices, but it is not good to be without temptations.
- Walter Bagehot
We look into mirrors but we only see the effects of our times on us - not our affects on others.
- Pearl Bailey
There is never time in the future in which we will work out our salvation. The challenge is in the moment; the time is always now.
- James Baldwin
Luck? I don't know anything about luck. I've never banked on it, and I'm not afraid of people who do. Luck to me is something else: hard work - and realizing what is opportunity and what isn't.
- Lucille Ball
Solitude is fine, but you need someone to tell you that solitude is fine.
- Honore De Balzac
If you wait until you can do everything for everybody, instead of something for somebody, you'll end up not doing anything for anybody.
- Malcolm Bane
Posted by Fireman John at 9:34 AM 0 comments
Friday, August 17, 2012
weekly update
celebrity lowlights in the world of substance
abuse from About.com/Alcoholism;
Bobby Brown in Rehab After DUI Plea Deal
As part of his drunk driving plea agreement, singer Bobby Brown has checked himself into an undisclosed treatment facility. To avoid a DUI conviction from his March arrest, Brown agreed to complete a 90-day alcohol rehab program.
Jenna Jameson Pleads Guilty to DUI
Former porn actress Jenna Jameson has entered a guilty plea to driving under the influence stemming from a May 25 incident in which she crashed her Range Rover into a utility pole. She will serve three years informal probation, pay $340 in fines, enroll in a first-time offender DUI course, and participate in a victim impact panel.
Jury Convicts D.J. Williams in DUI Trial
Denver Broncos linebacker D.J. Williams was able to avoid a driving under the influence conviction by going to trial, but the jury did convict him of driving while ability-impaired. He was also convicted of driving without headlights, which got him pulled over at 3 a.m. in the first place.
Jessica Simpson's Dad Joe Arrested for DUI
Jessica Simpson's father, Joe Simpson, has been officially charged with driving under the influence after being stopped by police in Sherman Oaks, California. Simpson was booked and released without having to post bail.
Crocs Founder Arrested for Drunk Driving
When police found the 51-year-old millionaire founder of Crocs shoes passed out behind the wheel of his Porsche and arrested him for suspicion of driving under the influence, he told the arresting officers that his "girlfriend" was actually driving the car. He also told them that his girlfriend was 22-year-old singer Taylor Swift.
FSU Cuts Greg Reid for Weed Possession
Pre-season All-American pick Greg Reid has been cut from the Florida State University football team after an arrest for possession of marijuana. Reid claimed that the weed the police found in the car he was driving did not belong to him. Problem was he was the only one in the vehicle.
Posted by Fireman John at 5:36 AM 0 comments
Sunday, August 12, 2012
Monday quotes
The only simularities in this world is how everything is different.
- Christopher Acedillo
Liberty is not the power of doing what we like, but the right of being able to do what we ought.
- Lord (John Emerich Edward Dalberg) Acton
We can accomplish almost anything within our ability if we but think that we can!
- George Matthew Adams
A psychiatrist is a fellow who asks you a lot of expensive questions your wife asks for nothing.
- Joey Adams
Thoroughly to teach another is the best way to learn for yourself.
- Tryon Adams
Friendship improves happiness, and abates misery, by doubling our joys, and dividing our grief.
- Joseph Addison
We all live under the same sky, but we do not all have the same horizon.
- Konrad Adenauer
Every truth has two sides. It is well to look at both before we commit ourselves to either side.
- Aesop
You can tell more about a person by what he says about others than you can by what others say about him.
- Leo Aikman
Service to others is the rent you pay for your room here on earth.
- Muhammad Ali
Posted by Fireman John at 9:55 AM 0 comments
Friday, August 10, 2012
weekly update
substance abuse and celebrity news
from About.com/Alcoholism;
Posted by Fireman John at 5:33 AM 0 comments
Sunday, August 5, 2012
Monday quotes
I have always known that at last I would take this road, but yesterday I did not know that it would be today.
- Narihara
Lack of will power has caused more failure than lack of intelligence or ability.
- Flower A. Newhouse
What's going on in the inside shows on the outside.
- Earl Nightingale
We don't see things as they are, we see them as we are.
- Anais Nin
The secret of success is to know something nobody else knows.
- Aristotle Onassis
When we come into this life, we don't really own anything. And we own nothing when we leave. It is only a lease we have during our lifetime - and it is up to us to make the most of it.
- Jerold Panas
The more you do, the more you are.
- Angie Papadakis
The guy who takes a chance, who walks the line between the known and the unknown, who is unafraid of failure, will succeed.
- Gordon Parks
Success is how high you bounce when you hit bottom.
- General George Patton
Part of the happiness of life consists not in fighting battles, but in avoiding them. A masterly retreat is in itself a victory.
- Norman Vincent Peale
Posted by Fireman John at 12:04 PM 0 comments
Friday, August 3, 2012
weekly update
latest celebrity substance abuse news
from About.com/Alcoholism;
Actress Tatum O'Neal Back in Rehab
Media reports claim actress Tatum O'Neal is back in rehab dealing with a cocaine problem. The Academy Award-winning, 48-year-old actress is trying out a different treatment center this time, reports said.
Snoop Dogg Banned From Norway For 2 Years
Rapper Snoop Dogg has been banned from entering the country of Norway for the next two years after he arrest last month for marijuana possession. Snoop's Norwegian attorney told reporters the artist "can live with the decision" and does not plan to appeal.
Macaulay Culkin's Addiction Fictitious Rep Says
A tabloid newspaper's claim at actor Macaulay Culkin is a heroin addict is false, according to his media representative. The "Home Alone" actor's rep told media outlets that the accusation "is not only categorically without merit, but it is also impossibly and ridiculously fictitious."
Jon Jones Sentenced for DWI
UFC champion fighter Jon Jones has been sentenced for a May 19 drunken driving arrest. Jones will lose his license for six months, paid $1,000 fine, install an interlock device on his vehicle, complete a victim impact program, serve one-year on conditional discharge and pay $6,563.62 for the utility pole he wrapped his 2012 Bentley around.
Ohio State RB Dunn Dodges Drug Charges
Ohio State running back Bri'onte Dunn dodged drug possession charges and was instead charged with disorderly conduct and two traffic charges. After Dunn was stopped for running a red light, police found marijuana and a wooden pipe in the vehicle.
Drunk Woman Tries to Break Into Jail
Ah, isn't it supposed to be the other way around? Butler County, Ohio deputies are still trying to figure out why an intoxicate 36-year-old Tiffany R. Hurd tried to break into the county jail by climbing over the back fence. They arrested her after they repeatedly ask her to leave, but she refused and tried to climb the fence again.
Posted by Fireman John at 7:42 AM 0 comments


text:
Homemade Raspberry Ice Cream Cake With Chocolate Crumb Crust Recipe
Lost classic desserts from our wide and varied past.
For this cake you can use any kind of ice cream you want (you don't have to be a hero, I won't tell if you didn't make the ice cream from scratch; we know the cake is all about the chocolate cookie crunchies). Since this cake is really a glorified vector for crunchie consumption, feel free to substitute whatever homemade or store bought ice cream you enjoy with chocolate.
I prepared a very simple raspberry ice cream. It's low on added sugar so the raspberry and cream flavor comes through, lending it a pleasant freshness. For this recipe I prefer frozen raspberries for a few reasons: unless raspberries are in peak season, you can get frozen organic raspberries for cheaper than fresh ones and when the berries defrost they release a good deal of bright pink juice that gives the ice cream a lovely pink hue while allowing for lots of whole berry pieces to be mixed throughout (as opposed to mashing up fresh berries).
The cookie recipe is adapted from the Smitten Kitchen's chocolate wafer cookie recipe. In a pinch you can use Nabisco Chocolate wafers (the kind of cookies called for in ice box cake). Use at least two 9-ounce boxes. For true crunchie fiends you might want to up that to three boxes.
- Yield:Serves 12
- Active time: 1 1/2 hours
- Total time:4 1/2 hours plus overnight chilling
- For the Ice Cream:
- 6 egg yolks
- 1/2 cup sugar
- 2 cups heavy cream
- 1 cup whole milk
- 1/4 teaspoon of salt
- 2 cups frozen raspberries, defrosted
- 2 teaspoons vanilla extract
- For the Chocolate Cookie Crunchies:
- 1 1/2 cups (about 7.5 ounces) all-purpose flour
- 3/4 cup best quality unsweetened cocoa powder
- 1/4 teaspoon salt
- 1/4 teaspoon baking soda
- 14 tablespoons (1 3/4 sticks) unsalted butter, slightly softened, plus 3 tablespoons, melted
- 3/4 cup (about 5 ounces) sugar
- 3 tablespoons whole milk
- 2 teaspoons vanilla extract
In a medium bowl lightly beat egg yolks with a 1/4 cup of sugar and set aside. In a medium saucepan add cream, milk, salt, and remaining sugar. Heat mixture over medium low heat, whisking occasionally, until bubbles begin to form along the edges of the pan. Remove from heat and add heated cream mixture to eggs one tablespoon at a time while whisking constantly.
Once the cream mixture and eggs have been combined return to the saucepan and heat on medium low until mixture coats back of a spoon or spatula and line drawn with a finger leaves a distinct trail. Mixture should register 170° to 175° F on an instant read thermometer. Do not allow mixture to overheat.
Pour custard into a medium bowl and whisk in raspberries and vanilla extract. Set bowl over an ice bath. Let cool at room temperature for 1 hour, stirring occasionally, then cover and refrigerate for 2 more hours or until completely chilled.
While the custard is chilling, prepare your cookies. In a medium bowl whisk together, flour, cocoa powder, salt and baking soda. Set aside. In the bowl of a stand mixer fitted with a paddle attachment, add 14 tablespoons softened butter and sugar and beat on medium high speed until light and creamy about 3 minutes. Add flour mixture and beat on medium speed until just combined, then add milk and vanilla and beat until dough comes together. Remove dough from bowl and shape into two logs that are approximately 1 1/2 inches in diameter. Wrap dough logs with plastic wrap or waxed paper and chill in the refrigerator for at least an hour or place in freezer for about 30 minutes or until logs are firm enough to slice.
Adjust oven rack to center position and preheat oven to 350° F. Slice thin wafers (about 1/8 inch thick) from the cookie log and place at least 1 ½ inches apart on a parchment lined baking sheet. Bake cookies for 5 minutes, rotate pan and continue baking until edges of cookies are slightly crisp, about 5 to 8 minutes longer.
Allow cookies to cool for 2 minutes on the pan then transfer to a wire rack to cool completely. Once cookies are completely cooled place in a large zipper lock bag and coarsely crush them.
In a medium bowl combine 2 cups of cookie crumbs with remaining melted butter until crumbs are thoroughly moistened. Press crumb mixture into the bottom of a springform pan. Set aside.
Churn chilled custard according to your ice cream maker's instructions. Transfer half of the ice cream to the prepared springform pan, spreading it with a spatula to completely cover the crumbs. Cover ice cream evenly with half of the remaining crumbs then repeat, covering those crumbs with remaining ice cream and topping off the cake with crumbs. Cover pan with plastic wrap and freeze overnight.
Release sides of pan to serve cake and allow cake to thaw for several minutes before cutting and plating.
This Recipe Appears InAmerican Classics: Raspberry Ice Cream Cake
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text:
On last night's episode, the director of the Southern Glitz Pageant didn't even pretend that "inner beauty" plays into the scoring of the children who competing. So with that in mind, let's judge the following by looks alone.
To get things started, let's her the pageant director explain the importance of beauty.
So, if these people place so much value on beauty, and wish to visit those values upon their children, why are they not leading by example? I'm not saying this woman is ugly. I'm just saying that she thought it was important to put a wig on a 4-year-old.
If judges are only going to base their scoring on the external, then I find this to be a perfect response.
This girl clearly doesn't give two glitz about winning.
It's kind of sad when a 3-year-old resigns herself to having emotions that match her hair, lashes, teeth, and fingertips. She needs to just let it all out. Like that other girl who farted.
Finishing this sentence?


text:
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Nabors has developed a suite of software solutions designed to transform rig site data and analytics into wellsite knowledge. Drilling data is collected from various rig sources and then transmitted to customers in real-time through remote, mobile portals.


text:
It's World Series or bust for talented Tigers
Individual awards are nice, but squad will be judged by October success
Hey, look at these Detroit Tigers. Isn't this just what we expected from them? Talented. Tough-minded. Resilient.
The Tigers have won 16 of 17, including 12 in a row, completely blown open the American League Central, running their lead from 1 1/2 games to seven in a span of 18 days and outscoring the opposition, 100-36, during that span.
And guess what? It doesn't matter, at least not in any larger sense. These Tigers will be judged by how much they win in October. That's their measuring stick. You won't hear them complaining about this.
This is one of those windows franchises sometimes have when the stars and moons are aligned. The Tigers are having a great season. They're entertaining to watch. In a summer in which Detroit could use some good news, the Tigers are doing their part.
Still, it's all about October. Is that fair? Sure, it is.
It's the price for having a club with talent and depth and experience, a club with one of the game's great managers in Jim Leyland and a general manager in Dave Dombrowski who is one of the gold standards for every other.
Detroit has arguably the best rotation in the game, led by 17-1 Max Scherzer The Tigers have the game's best offensive player in third baseman Miguel Cabrera , and a five-time All-Star in first baseman Prince Fielder.
Since Joaquin Benoit slipped comfortably into the closer's role -- converting 10 straight saves and allowing one earned run in 16 appearances -- Detroit is a team without a weakness.
Or so it seems.
Again, though, it's about October.
So here's why this October might be different than last October. And lest we forget, last October wasn't too bad.
The Tigers went a long time before hitting their stride last season. They didn't clear .500 for good until the 85th game of the season and finally climbed alone atop the AL Central to stay in the 155th.
Later, they would say nothing had come easy. They wouldn't say that it was the burden of expectations, not exactly. At least not that they knew. Sometimes, stuff happens.
The 2012 Tigers never played the way they should they should have played. But they persevered and fought through tough times and ended up where they were supposed to be.
The Tigers got by the A's in a thrilling AL Division Series that went the full five games. Then they swept the Yankees in the AL Championship Series for their 11th pennant.
That's no small thing. October baseball in Detroit is a spectacular thing. Cool weather. Packed ballpark. And history.
Every great thing the Tigers do is somehow connected to the past, to Al Kaline or Hank Greenberg. To Denny McClain and 1968. To Sparky Anderson and his "Bless You Boys" in '84.
So the Tigers had plenty of cool moments, and while getting swept out of the World Series by the Giants and watching another team celebrate a championship on the field at Comerica Park was a tough way to end it, they'd had a terrific season.
Fast forward to 2013.
Again, a similar beginning. Yes, those high expectations. As usual, Dombrowski tweaked his roster by adding 37-year-old outfielder Torii Hunter.
Hunter gave the Tigers experience, leadership and a vocal presence in the clubhouse. Oh, by the way, he's hitting .310 and just made his fifth All-Star team.
Detroit also got Victor Martinez back from a knee injury that sidelined him for 2012, and with those two in a lineup that already had Cabrera and Fielder, there was offensive firepower almost from top to bottom.
Still, it all begins with starting pitching, and the Tigers might have the best in the game. During this 16-1 run, Detroit's starters have gone 13-1 with a 1.83 ERA, allowing more than two runs just twice.
This rotation is a tribute to Dombrowski, who did it the old-fashioned baseball way. He put it together a piece at a time, trading here, trading there.
Justin Verlander (12-8, 3.74) was the crown jewel of the Tigers' farm system, a 2004 first-round Draft pick who was critical in Dombrowski's construction of the franchise. Right-hander Rick Porcello (8-6, 4.28) was an '07 first-round pick who made his Major League debut at 20 in '09.
Otherwise, Dombrowski rolled up his sleeves and went to work. He doesn't just make trades. He makes big ones, bold ones.
Dombrowski got Scherzer from the D-backs in a three-team, seven-player deal in 2009. And then Doug Fister (10-5, 3.50) came from the Mariners in '11 as part of a six-player deal. Finally, Dombrowski put the finishing piece in place last summer by getting Anibal Sanchez (9-7, 2.58) from the Marlins in a five-player swap.
Detroit's rotation leads the AL in victories, ERA, innings and strikeouts. Scherzer is second in the AL in strikeouts, followed closely by Verlander (sixth) and Sanchez (11th).
Those starters are a lot like their manager, Leyland. That is, relentless and workmanlike. Having managed 3,450 games over 22 seasons, he long ago learned to roll with the punches.
Is this a special team? It could be. On the other hand, the Pirates, Braves, Dodgers and Rays think it might be their year, too. Parity rules.
Meanwhile, Cabrera (33 home runs, 105 RBIs) seems headed for a second straight AL Most Valuable Player Award and Scherzer can begin clearing shelf space for an AL Cy Young Award.
But the Tigers are all about October. It's the month that will define them.


text:
Immune Reconstitution Syndrome in HIV-Infected Patients Taking Antiretroviral Therapy
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00286767
Recruitment Status : Completed
First Posted : February 3, 2006
Last Update Posted : October 7, 2019
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
This study will investigate what factors may lead to the development of immune reconstitution syndrome (IRIS) in HIV-infected patients and what the outcome is after IRIS. It will also seek to better define and describe the syndrome. IRIS is a condition that can occur in HIV-infected people following the start of antiretroviral therapy. The sudden improvement of immune function with this therapy can cause an unexpected worsening of diseases the patient already has, such as tuberculosis or fungal infections, and development of fever, enlarged lymph nodes or other complications, or even uncover a previously silent disease.
HIV-infected people who are at least 18 years old, whose CD4+T cell count is 100 cells per microliter or less, and who have not previously been treated with combination antiretroviral therapy or have taken the drugs for less than 3 months and more than 6 months before screening for this study may be eligible to participate. Candindates must also live within the wider DC area so that acute problems after therapy initiation will be evaluated at NIH. Candidates are evaluated before starting therapy with a medical history and physical examination, blood and urine tests, electrocardiogram, chest x-ray and CT scan of the chest, tuberculin skin testing, apheresis, and possibly an intestinal (gut) and lymph node biopsy (surgical removal of a small piece of tissue for microscopic examination). For apheresis, blood is collected through a needle in an arm vein and spun in a machine that separates the blood components. The white blood cells and plasma are removed, and the red cells and platelets are returned through the same needle or through a needle in a vein in the other arm.
Participants have a complete history and physical examination and additional blood tests, including genetic studies, upon entering the study. They start taking anti-HIV medications, prescribed according to the current standard of care, as well as medications to treat other infections, and treatment of IRIS, if needed. The study lasts about 4 years. Patients return to the clinic at 2, 4, 8 and 12 weeks after the entry visit, then every 12 weeks (about every 3 months) until week 48 (the first year), and then every 16 weeks (about every 4 months) until the end of the study. At most visits, patients have a medical history, physical examination and blood and urine tests, including CD4+T cell count and HIV plasma viral load measurement. Apheresis is also done at weeks 24 and 48 and then once every 48 weeks. Intestinal and lymph node biopsies (optional) are also done at weeks 24 and 48. A syphilis test and PAP smear (for women) are done yearly. and plasma, cells and serum are stored at almost every visit for immunologic studies.
|Condition or disease
|Immune Reconstitution Inflammatory Syndrome
A cohort observational study evaluating the predictors, incidence, clinical presentation and immunopathogenesis of Immune Reconstitution Syndrome (IRIS) in human immunodeficiency virus (HIV-1) infected patients with CD4 Count less than or equal to 100 cells/microL who are initiating antiretroviral therapy.
Immune reconstitution syndrome (IRIS) is a clinical syndrome that has been described in HIV infected patients after initiation of highly active anti-retroviral therapy (HAART), and is characterized by paradoxical acute worsening of an underlying opportunistic infection or AIDS-defining illness. There is no widely accepted syndromic definition, the pathogenesis of the syndrome is unclear and there is no specific therapy. The syndrome is more common in patients with low CD4+ T cell counts (less than 50 cells/microL) and in those with certain underlying infections (e.g. mycobacterial or cryptococcal infection) and is typically observed when there is evidence of response to HAART and while patients are still at risk for other opportunistic infections (OIs) or AIDS defining illnesses (e.g. pneumocystis jirovecii pneumonia or cytomegalovirus [CMV] retinitis). The incidence of IRIS varies depending on the studied population and is very frequent in developing countries creating significant diagnostic and therapeutic challenges as well as utilization of limited health resources.
DESIGN: International observational cohort study. Participants will be evaluated at baseline and followed according to the protocol follow up schedule after initiation of antiretroviral therapy for a total of two years. Acute symptoms that may be representing manifestations of IRIS will also be evaluated at additional acute care visits if necessary.
DURATION: Enrollment is ongoing. Each volunteer will be followed for at least two years. Total duration of the study will be approximately 8 years (including the optional extension phase in US).
SAMPLE SIZE: Approximately 600 patients will be enrolled, 200 in Kenya, 100 in Thailand and 300 in US. (enrollment is US will continue until approximately the other sites are full). Based on the incidence of IRIS in patients with low CD4 counts (approximately 20-40 percent), we anticipate strong power (approximately 90 percent) to identify baseline factors predictive of IRIS.
POPULATION: HIV-l-infected men and women, age greater than or equal to 18 years, antiretroviral therapy (ART)-naive with CD4+ T cell counts less than or equal to 100 cells/mm(3). Participants will be recruited and followed at three sites: the broader Washington DC, Kericho, Kenya and Bangkok, Thailand areas.
REGIMEN: Participants will be initiated on ART according to the clinical standard of care. If an OI or other AIDS defining illness is identified prior to or during screening or at any point during the study, they will also be treated according to standard of care.
|Study Type :
|Actual Enrollment :
|525 participants
|Observational Model:
|Time Perspective:
|Official Title:
|A Cohort Observational Study Evaluating Predictors, Incidence and Immunopathogenesis of Immune Reconstitution Syndrome (IRIS) in HIV-1 Infected Patients With CD4 Count Less Than or Equal to 100 Cells/microL Who Are Initiating Antiretroviral Therapy
|Study Start Date :
|February 1, 2006
|Study Completion Date :
|November 1, 2018
- To identify baseline predictors of IRIS within 6 months of HAART initiation prospectively in a group of HIV-1 infected patients with advanced disease who are starting antiretroviral therapy. [ Time Frame: During the data analysis phase at the end of the study ]
- To evaluate the immunopathogenesis of IRIS with the goal to identify more appropriate targets for future therapeutic interventions. [ Time Frame: During the data analysis phase at the end of the study ]
- Evaluate the baseline clinical and immunological characteristics ofindividuals who develop IRIS and compare them with those who do not. [ Time Frame: During the data analysis phase at the end of the study ]
- To study the incidence and clinical manifestations of IRIS prospectively in a group of HIV-1 infected patients with advanced disease who are initiating antiretroviral therapy. [ Time Frame: During the data analysis phase at the end of the study ]
- To evaluate the impact of IRIS on the risk of subsequent death (attributable mortality). [ Time Frame: During the data analysis phase at the end of the study ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 99 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
For the National Institutes of Health (NIH)/US site: HIV-1 infection, as documented by OraQuick rapid test using venipuncture whole blood, or fingerstick whole blood done at screening; or by reactive enzyme-linked immunosorbent assay (ELISA) and Western Blot as determined by NIH Clinical Pathology Laboratory or Leidos Biomedical Research, Inc. Monitoring Laboratory. HIV infection as determined by an outside Clinical Laboratory Improvement Amendments (CLIA)-approved laboratory facility" will be accepted for enrollment and verified by a standard HIV-1 ELISA with Western Blot at NIH.
For Keny Medical Research Institute/Walter Reed Project Clinical Research Center (KEMRI/WRP CRC)/Kenya site: HIV-1 infection will initially be diagnosed based upon two, serial rapid HIV tests according to Kenya Ministry of Health (MOH) guidelines. Volunteers entering this study will have HIV infection confirmed by two serial rapid HIV test in accordance with Kenya MOH guidelines and testing algorithm followed by a confirmation with a Western Blot using FDA approved-kits. Samples from participants with discrepant results (between the results from other institution and KEMRI/WRP-CRC laboratory) and/or indeterminate/negative Western Blot will be subjected to a nucleic acid assay i.e. DNA or RNA PCR. For Thailand, HIV-1 screening and confirmatory testing will be based on 3, HIV tests according to the Thai Ministry of Public Health guidelines. The subjects will initially be tested with a chemiluminescent microparticle immunoassay (CMIA) method that detects both HIV antigen and antibody. Confirmatory testing of HIV reactive samples by two different antibody detection methods will follow. Positive results by all three methods confirm HIV diagnosis. Discrepancy between the tests will require a nucleic acid detection method to confirm HIV diagnosis.
- No previous treatment with potent combination anti-retroviral therapy (ART), defined as any protease inhibitor (PI)-based or non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimen, or even triple nucleoside reverse transcriptase inhibitors (NRTI)-based regimen, consisting of at least three antiretroviral drugs (including a boosted PI with NNRTI combination). Patients with limited use of ART (less than 12 weeks duration) more than 24 weeks before screening will be eligible for study participation.
- Screening CD4+ cell count less than or equal to 100 cells/mm(3). * Note: CD4 < 100 cells/microL from an outside or the site s laboratory within 8 weeks prior to screening can be accepted as the screening value.
- Residence within the wider Washington D.C. area (approximately within a 120-mile radius from the NIH Bethesda campus) for the National Institutes of Health/US site and residents of the Kericho District Hospital catchment area, an approximate 93-mile (150 kilometers) radius, for the KEMRI/WRP CRC/Kenya site. Residence within the Bangkok Metropolitan area and nearby provinces are allowed to participate (approximately 120-mile radius from each of the clinical sites)
- Men and women age greater than or equal to 18 years.
- Ability and willingness of subject or legal guardian/representative to understand study requirements and give informed consent.
- Be willing to allow storage of blood or tissue samples for future research. (For Thailand: storage of blood or tissue samples is an optional procedure and therefore not a inclusion criteria)
- Be willing to have HLA testing. (For Thailand: HLA testing is an optional procedure and therefore not an inclusion criteria)
- For the NIH/US site: Participants should have a primary care physician or will need to agree to find one during the first 24-48 weeks on study. For the KEMRI/WRP/Kenya site: Participants must be enrolled in the Kericho District Hospital HIV Clinic. For the two Thailand clinical sites: participants must be enrolled in the HIV clinic at either of the sites.
- Active drug or alcohol use or dependence that, in the opinion of the investigator, would interfere with adherence to study requirements.
- Pregnancy will be an exclusion criterion for study entry given the intense nature of the protocol regarding blood draws, diagnostic testing, and follow-up.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00286767
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|The Thai Red Cross AID Research Center (TRC-ARC)
|Bangkok, Thailand, 10330
|Bamrasnaradura Infectious Disease Institute (BIDI)
|Nonthaburi, Thailand, 11000
|Principal Investigator:
|Irini Sereti, M.D.
|National Institute of Allergy and Infectious Diseases (NIAID)
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|National Institute of Allergy and Infectious Diseases (NIAID)
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|February 3, 2006 Key Record Dates
|Last Update Posted:
|October 7, 2019
|Last Verified:
|November 1, 2018
Opportunistic Infections
Immune Restoration Disease
Mycobacterial Infections
HIV-1 Infection
ART Naive
Immune Reconstitution Inflammatory Syndrome
Pathologic Processes
Immune System Diseases


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Game Six featured eleven innings, five official errors, numerous others in judgment, and what will not be Albert Pujols' final plate appearance in a Cardinals uniform—a tenth-inning intentional walk—but it was an official game and then some, one the Texas Rangers did not win.
The Cardinals owe their stay of execution to David Freese, whose 9th-inning triple with two outs and two strikes forced extras, and whose 11th-inning walkoff homer ensured the first World Series game seven since 2002. Lance Berkman also fought off a two-strike, two-out 10th-inning guillotine by delivering an RBI single. That, of course, was forced by man-of-many comebacks Josh Hamilton, who gave the Rangers a 9-7 lead in the top of the 10th.
We'll be talking all about this game Friday, but for now, enjoy the majesty that is David Freese.


text:
) -- Major U.S. stock averages slumped Monday, dragged down by political uncertainties in Europe and disappointing factory orders here at home.
Spain's opposition Socialist Party urged Prime Minister Mariano Rajoy to step down over corruption allegations, which he has refuted. An external investigation on the matter is expected to begin in a few weeks. The Spanish prime minister and German Chancellor Angela Merkel were to meet in Berlin Monday ahead of the European Union leaders' summit in Brussels later this week.
In Italy, former Prime Minister Silvio Berlusconi is experiencing mounting popularity, potentially interfering with reforms carried out by the incumbent technocrat government. Italy's general elections are scheduled to start in late February.
Amid the news, the yield on the Spanish 10-year bond soared to its highest level since December at 5.3%. The DAX in Frankfurt declined 2.5% and the FTSE in London fell 1.6%.
Dow Jones Industrial Average
plunged 102 points, or 0.7%, to 13,908.
Breadth was overwhelmingly negative, with 29 of 30 components in the red. The biggest percentage blue-chip laggards were
(TRV) - Get Report
(MRK) - Get Report
(MSFT) - Get Report
Bank of America
(BAC) - Get Report
Microsoft was down 1.4%. Negotiations on buying out
(DELL) - Get Report
continued over the weekend, with reports saying a deal could be achieved in a matter of days. CEO Michael Dell, private-equity firm Silver Lake Partners and Microsoft are reportedly the buyers. Dell shares were down more than 2.5%.
(CVX) - Get Report
also slumped.
Chevron was downgraded to "neutral" from "buy" at UBS on a valuation basis. Shares fell 1.1%.
fell 17 points, or 1.2%, to 1,496. The
slid 48 points, or 1.5%, to 3,131.
All sectors in the broad market were in the red. The heaviest decliners were energy, conglomerates, financials and technology.
Volumes were at 3.36 billion shares on the
New York Stock Exchange
and 1.86 billion shares on the Nasdaq. Decliners were outnumbering advancers by a ratio of 3.6-to-1 on the Big Board and 3.3-to-1 on the Nasdaq.
The Dow broke 14,000 on Friday for first time since 2007 and logged the longest weekly winning streak since the six-week period ended Aug. 17.
"In our view, we believe stock prices can continue to rise, but we would encourage selectivity when investing," a BlackRock note said. "We continue to favor emerging markets (including China) and mega-cap U.S. stocks, which should benefit from the improvements in the global economy."
"Given the strong market internals, we believe both the Dow and the S&P 500 will retest its 2000/2007 in coming weeks," Piper Jaffray's technical research team said in a morning note. "Our intermediate-term market timing gauges remain in buy positions and our short-term gauges are close to being overbought," the team added.
The U.S. economic calendar is comparatively light this week after last week's data deluge.
The Census Bureau said Monday that factory orders rose 1.8% in December after falling by a downwardly revised 0.3% in November. Economists were expecting factory orders to rise 2.2% in December.
"Although slightly light relative to consensus expectations, this report further corroborates the picture of manufacturing reacceleration painted by the recent ISM data," said John Ryding and Conrad DeQuadros, the founders of research firm RDQ Economics.
This week, 89 companies in the S&P 500 are expected to report fourth-quarter earnings, according to
Thomson Reuters
Thomson Reuters
report, released Friday evening, said fourth-quarter earnings are now expected to grow 3.8% from a year earlier.
Of the 239 companies in the S&P 500 that have reported earnings to date for fourth quarter, 68% have reported earnings above analyst expectations, according to
Thomson Reuters
. This is higher than the long-term average of 62% and higher than the average over the past four quarters of 65%.
Gold for April delivery added $5.80 to settle at $1,676.40 an ounce at the Comex division of the New York Mercantile Exchange, while March crude oil futures lost $1.60 to close at $96.17 a barrel.
The benchmark 10-year Treasury gained 16/32 to lower the yield to 1.960%. The dollar rose 0.45%, according to the
In corporate news,
(CLX) - Get Report
posted quarterly earnings of 93 cents a share on revenue of $1.33 billion, surpassing the average analyst estimate of 81 cents a share on revenue of $1.27 billion. The consumer products company's home-care business experienced a surge in demand for disinfecting wipes due to the severity of this year's flu season. Shares gained 0.71%.
The company raised its full-year outlook to 3% to 5% sales growth.
(ORCL) - Get Report
opened its wallet again, announcing a
$1.7 billion deal to acquire networking specialist
Acme Packet
. Acme Packet shares soared 23%. Oracle shares shed 3.1%.
(HLF) - Get Report
shares slumped 1.3% as the
New York Post
reported that the weight-management and nutritional-supplements company is the subject of a law-enforcement probe.
(HUM) - Get Report
posted fourth-quarter earnings of $1.19 a share, beating the average Wall Street forecast of $1.07 a share as the health insurer's operating cost ratio declined. Revenue came in at $9.56 billion, versus the average expectation of $9.73 billion. Shares popped 4.7%.
(SYY) - Get Report
shares tumbled 2.7% after the North American distributor of food and related products said its quarterly net earnings decreased 11.5% from the prior year with food cost inflation at 2.5%, driven mainly by increases in the poultry and meat categories.
-- Written by Andrea Tse and Joe Deaux in New York.
>To contact the writer of this article, click here:
Andrea Tse


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|Craft Kits & Accessory Type : Craft Materials
|Craft Kit & Accessory Number of Pieces : 8
|Weight : 2.00 lbs. per Pack
|Brand : DecoArt
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|Weight : 2.00 lbs. per Pack
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text:
I'm off to Adelaide later tonight for a two week holiday to visit my family and friends there.
My shop will still be open during this time, but please note that orders won't be posted until 1st March when I return. Hope you all have a lovely valentines day whatever you choose to do!
The Avenging Angel top in creme
My Game Show Queen skirt in biscuit
Secret Minds bow clip in berry
Save Me knee high socks in plum
My Gossip Queen jacket in pale pink
Jealous Angel cuffs in biscuit
Jealous Angel collar in biscuit
My Tim Tam Crush dress in biscuit
Words of Love velvet belt in berry


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Family Advocates In
Get free legal advice from the Family Lawyers in India. Hire the Best Law Firms for your Legal issues. Family Lawyers in India are listed here,to provide fast,cost effective legal services in India. Here you will get Family Advocates in India for your legal issues. immigration lawyers, litigation attorneys, injury lawyers, employment lawyers, family law Advocates, Family Lawyers In India are available here.


text:
- A page from an annotated photo album featuring a photograph of a letter written by the medium, Mrs. Poole, to Lillian Hamilton, dated November 15, 1930, in which Mrs. Poole describes her recollections of an event., Luna Collection ID - 28::UMANITOBALCM::NA, Luna Object ID - 83296, Luna Image ID - 119175
Primary tabs
Hamilton Family fonds
The Hamilton Family fonds details Dr. T.G. (Thomas Glendenning) and Lillian Hamilton's investigations of psychic phenomena in their home in Winnipeg, Manitoba between 1918 and 1945. The images detail numerous aspects of spiritualism including telekinesis, teleplasm, trance states and various other psychic phenomena. This site is comprised of over 700 images from the Hamilton Family photograph collection and over 1300 notes and accompanying documentation pertaining to seances held in the Hamilton's home. The entirety of the photograph collection has been digitized with the exception of duplicate photographs of the same image. It includes digital reproductions of photographs, stereo photographs, slides, negatives and glass slide negatives, as well as some accompanying textual records.


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Dissecting Michelle Obama
I started this article with every intention of going through Michelle Obama's entire speech at the DNC convention. That didn't work out as planned. I got about a quarter of the way through her speech before I just could not bear even to look at the text of it anymore. It is beyond absurd. I will go through the rest of it at a later date, if my scheduling allows.
But even just this first portion is incredible!!!
"Over the past few years as first lady, I have had the extraordinary privilege of travelling all across this country."
WE KNOW! You've travelled all over this country and several other countries… ALL ON OUR DIME.
She goes on from here to talk about wounded warriors and heroes that make sacrifices for other people, often risking their lives. I would have no quarrel with that part of it, except that it is obvious empty rhetoric and pandering to a group that does not support this president because they know full well how much (or little) he has supported them.
"Serving as your first lady is an honor and a privilege. But, back when we first came together four years ago, I still had some concerns about this journey we'd begun."
Wait… Serving..? How exactly is she serving us? By telling us what we should feed our children? By vacationing and partying at the taxpayer's expense? And yes, Michelle, we are all fully aware that you had some "concerns" about the "journey we'd begun". We know that you first became proud of America only after your husband was elected. We have doubts about just how proud you are of America, even today.
"While I believe it if we dig deeply in my husband's vision for this country, and I was certain he would make an extraordinary president, like any mother, I was worried about what it would mean for our girls if he got that chance. How would we keep them grounded under the glare of the national spotlight? How would they feel being uprooted from their school, their friends and the only home they'd ever known?"
"See our life before moving to Washington was filled with simple joys. Saturdays at soccer games, Sundays at grandma's house, and a date night for Barack and me with either dinner or a movie because as an exhausted mom, I couldn't stay awake for both."
One should EXPECT laughter after hearing this joke! Hell, I don't even know where to begin! Obviously Michelle learned something about writing an auto-biography from her husband. Her narrative here is just as fake as anything that Barack wrote (assuming he actually wrote it) in Dreams of My Father. Where are the fact checkers now? Michelle Obama was NOT a soccer mom!!! Not even REMOTELY a soccer mom! But here she claims to have been pulled from that care-free life to serve as First Lady..?
This is the type of lying that liberals are known for, and the media will allow it to pass unchecked because they support the liberal agenda.
"And the truth is, I loved the life we had built for our girls. And I deeply love the man I built that life with and I did not want that to change if he became president."
"I loved Barack just the way he was. You see, even back then, when Barack was a Senator and presidential candidate, to me, he was still the guy who picked me up for our dates in a car that was so rusted out, I could actually see the pavement going by in a hole in the passenger side door."
This should read "incredulous laughter". Does anyone believe that Senator Barack Obama was driving around in a car that was rusted out? Anyone..? Liberals, do you really buy this crap?
There are two types of liberals; those that believe the lies, and those that happily repeat them, knowing they are lies.
"He was the guy whose proudest possession was a coffee table he'd found in a dumpster."
Senator Barack Obama was a dumpster diver?!
And PROUD OF IT?!
Michelle Obama just called the president a dumpster diver at the DNC convention, and not a single liberal media outlet even so much as cocked their head in wonder. On the contrary, they APPLAUDED!
This is like an episode of the Twilight Zone, folks!
The rabbit hole goes deeper from here. Too deep for me to get into tonight, but in preview, I will say that Michelle claims that their lofty Ivy League educations were paid for with student loans, and further claims that they had to work very hard to pay them off. Barack Obama went to Occidental, Columbia, and Harvard on Pell Grants and Stafford Loans..?
I would love to see some proof of that!
And I would love to see even one alphabet network fact check her speech.


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Key Account Specialist - Dermatology - Devon, Gloucester, Hampshire, Wiltshire, Somerset & Avon
Our client is one of the largest privately-owned independent OTC and pharmaceutical manufacturers in the UK and exports worldwide. They continually grow their business every year in the UK and International markets by innovation and acquisition.
A new position has been created for a Key Account Specialist to focus on delivering sales and adding value to their well-known dermatology range.
The successful candidate would be interacting with targeted GP's, dispensing practices and hospital consultants in order to ensure maximum usage of products.
You will enjoy full autonomy of your territory and be able to plan and organise your own success.
This role will demand a very self-motivated pharmaceutical sales professional who has plenty of get up and go and is determined to succeed.
You should be able to demonstrate fine-tuned communication skills and integrate well in a teamwork environment.
This is an excellent opportunity to join a fast-moving environment where you can genuinely make a real difference.
Excellent base salary, bonus + car and Healthcare.
Please apply online or call CHASE on 0131 553 6664 to find out more
Reference Number: 30989
You may return to your current search results by clicking here.
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MONTREAL - Rachel Homan and Team Canada have served notice they're ready to defend their title at the Scotties Tournament of Hearts.
The defending champions grabbed the early lead and held on for a 9-6 win in nine ends over Quebec's Allison Ross on Sunday to emerge from the second day of play at the Maurice Richard Arena as the lone team yet to lose a match.
"It's where I hoped we'd be," said 24-year-old Homan (3-0). "You never know what's going to happen, but the team's playing really well. We've just got to keep rolling."
With previous victories of 8-3 over Manitoba and 9-3 over Ontario, both in eight ends, they have piled up points against some highly-regarded teams without yet having to go the full 10 ends.
But Homan and the team were most concerned about giving up three to Quebec (0-4) in the second, which drew a roar from the 2,281 in the seats.
"We gave up three in two, but that's alright — mistakes will happen," said Homan. "We're learning the ice and different draws will be different weights."
"I underthrew two halfway hits and that didn't turn out well and then Rachel threw one we thought was good but it sailed off," said Team Canada third Emma Miskew. "We got tricked a little on either the speed or the weight.
"We didn't throw any more finesse shots after that because it tricked us a little."
The evening draws saw two matches go to extra ends as both New Brunswick and P.E.I. pulled off victories.
New Brunswick's Andrea Crawford (2-1) scored a single in the 11th end to take a 4-3 win over British Columbia's 22-year-old skip Kesa Van Osch (1-3). And Kim Dolan (1-2) of P.E.I got her first victory of the tournament, 7-6 over Quebec in 11 ends.
In the other late draws, Newfoundland's Heather Strong (3-1) edged Yukon's Sarah Koltun (1-2) 6-5. Koltun scored singles in the ninth and 10th ends but fell short of the comeback. And Alberta's Val Sweeting (3-1) scored three in the sixth end en route to a 5-4 victory over Nova Scotia's Heather Smith (1-2).
The afternoon draw saw some wild finishes.
Stefanie Lawton (2-1) of Saskatchewan tied her game up with two in the ninth and then stole two in the 10th to win 8-6 over Sweeting.
"Tied up coming home, without hammer, we know what we have to do," said Lawton, whose side gave up two in the 10th to lose 5-4 to Manitoba in the morning draw. "We have to put up two guards and get one on the button.
"We got away with one when they kissed the guard and bit and I was able to put another on top of that and put the pressure on them. There's going to be lots of games that will be battles. You just have to keep plugging away."
Another cliffhanger saw Manitoba's Chelsea Carey (2-1) get the point she needed in the 10th to defeat the B.C. side 7-6.
And Ontario's Allison Flaxey (1-2) scored two in the 10th and a steal of one in an extra end to down Newfoundland by 8-7.
Homan won last year's Scotties as skip of Team Ontario, beating Jennifer Jones' Winnipeg rink in the final. Jones isn't at this year's tournament, having won an ultra-competitive qualifying tournament to represent Canada at the 2014 Winter Olympics in Sochi, Russia.
Other top teams bowed out in their provincial championships, some citing mental fatigue from trying to make the Olympic team. But Homan's side was spared that because they qualified automatically for the Scotties as the defending champions.
"That definitely helped us," said Miskew. "There's a lot of new faces here, but it's nice to see a lot of young teams here."
"We definitely have room to improve. We had a bad end but we were able to bounce back, so that was important for us. It seems every game you get a little better and that's our goal."
Team Canada is part of the youth movement.
Homan and Miskew are both 24, while second Alison Kreviazuk is 25. They've been playing together since they were young kids. Lead Lisa Weagle, 28, joined them later.
Building a big lead in the morning draw against Ontario allowed them to give some playing time to their alternate, Stephanie LeDrew, who substituted for Weagle for the final two ends.
"It's good to have her throw some shots and see the lines," Homan said of LeDrew. "You never know during a week if you're going to have to use her or not.
"Hopefully not. Hopefully she'll just be there to cheer us on, but it's good to get her in early."
LeDrew normally plays for Hollie Nicol's Toronto rink, but she was brought in as an alternate by Homan for last year's Scotties in Kingston, Ont., as well as for the 2013 women's world championship in Riga, Latvia. She got into three matches last year.
"I know what it is to be prepared to jump in at a moment's notice," said LeDrew. "I actually went for a jog around the arena in the sixth end to be prepared to go in the seventh, so I was warmed up and ready to rock."
LeDrew said it is usually a team decision to get the alternate some playing time.
"It tends to be on the ice between ends, if they have a big lead going," she said. "They see it as a good opportunity to throw the alternate in.
"They also want to get me in because I have to play in two games, for at least one end in each game, in order to be eligible for the jewelry (prizes) at the end of the week — the diamonds. So they're being good to me."
The match also pitted sister against sister as Alison Kreviazuk faced Lynn Kreviazuk, the Ontario second.
"Actually, I haven't played against Lynn in a few years, so this was kind of a first for me," Alison Kreviazuk said of her 22-year-old sister. "We get along great, so there's nothing negative.
"They played really well, they just had a few bad breaks. I know she'll pick it up for the next one."
The morning draw saw more one-sided wins as Yukon downed P.E.I. by 10-3 in eight ends. Nova Scotia, beat New Brunswick by 12-2, also in eight ends.
Yukon scored five in the eighth end to prompt P.E.I. to concede, while Nova Scotia had ends of four and five points in their romp over New Brunswick.


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Licensed salon & spa professionals can set up a Professional Account which entitles them to professional only pricing, professional only promotions and additional educational and marketing resources available to our salon & spa customers.
If you already have a Professional Account with us, please sign in below with your email and password in the "Sign In to My Professional Account" section.
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Zoya Nail Polish
Skylar by Zoya can be best described as a medium steel blue with a softened, dusty look and speckled by visible gold and silver shimmer flecks. A soft blue that's bold without being too dark, bright or flashy.
Finish - Metallic
Intensity - 5 (1 = Sheer - 5 = Opaque)
Tone - Cool
For Best Results
Step 1: Clean the nail plate with Remove Plus ( Remove ) nail polish remover and nail plate cleaner
Step 2: Choose and apply the right base coat: Zoya Anchor for regular healthy nails or Zoya GetEven for nails with ridges
Step 3: Apply 2 coats of your favorite Zoya Nail Polish Color
Step 4: Apply a coat of Zoya Armor Top Coat
Step 5: Drop one drop of Zoya Fast Drops to the base of your nail bed
Following these 5 steps guarantees up to 14 days of wear on natural nails.
Shade Spotlight
Ratings & Reviews
Zoya Nail Polish | SkylarUnusual Color-Prettier On the Nail
I saw swatches of Skylar on a popular nail blog and loved it. When I first saw the bottle, though, I thought "meh." However, when I put it on it was really fresh and beautiful. The ease of application wasn`t perfect but I`d give it a 4/5. The only improvement I would suggest is to use more of the pink glitter in this. I found it really hard to see the pink in any light when I searched for it. Just a few here and there. I still love it though!


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What are circuit breakers and their uses?
First developed in the 1920's, a circuit breakers function is to provide protection for a circuit from excess current in a similar way to a fuse, but it is a switch device that can be reset if it is tripped. They can be used in anything from small electronic devices to household breaker boxes or electrical substations. Their main advantages are that they're reusable and can react quickly in the event of a fault, making them ideal for applications such as the fault protection switches found in many houses.
How does a circuit breaker work?
There are many types of circuit breakers and they all work in a slightly different way. Essentially, when excess current is detected, theyre designed to trip a mechanism to break the circuit.
Circuit breaker types
Circuit breaker designs differ depending on the amount of voltage it is required to work with. There are several different circuit breaker designs available, with most of them being designed for a specific use. Here is a brief overview:
- Magnetic circuit breakers – use solenoid components to separate the contacts. These are complex circuit breakers that sometimes use fluid and hydraulic mechanisms to gain more control over the solenoid action.
- Thermal magnetic circuit breakers – react almost instantly to different types of overcurrent conditions using electromagnet and bimetallic strips.
- Residual current circuit breakers (RCCBs) – are used to protect against residual currently only and help to prevent injury from electric shocks. They are classified into types named by letter, types AC, A, B and S are most commonly used.
- Miniature circuit breakers (MCBs) – provide protection from overcurrent and short-circuit only. They are also classified into types, with types B, C and D being the most common.
- Residual circuit breaker with overload (RCBOs) – these devices are able to protect from short circuit, overload current and residual current as they combine all the functions of an MCB and an RCCB circuit breaker.
What is the difference between fuses and circuit breakers?
Fuses are simple devices that no longer work once they are used however, a circuit breaker can be reset and reused many times, within the limitations specified by the manufacturer.