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Plant-based drinks aren't healthier options for kids: experts
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NEW YORK (AP) — Jeremy Lin's emergence from utter obscurity has the New York Knicks gaining confidence and victories.
Kobe Bryant and the Los Angeles Lakers are rarely lacking in either of those categories.
A budding fan favorite among the faithful at Madison Square Garden, Lin faces possibly his toughest test yet Friday night as the Knicks attempt to defeat Bryant and the Lakers at home for the first time in more than five years.
New York (11-15) was one of the NBA's biggest disappointments during a woeful 2-11 stretch Jan. 12-Feb. 3, but Lin has provided a much-needed spark since then.
The second-year point guard, who played only sparingly prior to the last three games, is averaging 25.3 points and 8.3 assists during the Knicks' three-game winning streak.
Lin's opportunity has come amid the absence of Knicks stars Carmelo Anthony and Amar'e Stoudemire. Anthony is out with a strained right groin, while Stoudemire isn't expected back from grieving the death of his brother until Tuesday at Toronto.
In the meantime, Lin's sudden production and popularity has the Knicks selling shirts with "Linsanity" emblazoned across the front.
He lived up to the hype again Wednesday, scoring 23 points while shooting 9 of 14 from the floor and adding 10 assists in a 107-93 win at Washington.
"Like I said after the last game, I wouldn't have imagined this," said Lin, who went undrafted out of Harvard in 2010 and played his rookie season with Golden State, averaging 2.6 points in 29 games as a reserve.
Lin may be reviving both the Knicks' season and embattled coach Mike D'Antoni's job security.
"I think it's for real," D'Antoni said of Lin's surge. "The things that are real are his vision, which won't change; his speed, which won't change; his knowledge of the game, which won't change. I think it can only get better.
"He just does everything easy and the rest of the guys around him are playing the way we want to play."
Lin and the Knicks, who are looking to match their season-high four game winning streak from Jan. 6-11, are in for a major test against the Lakers (15-11).
The Knicks have lost nine in a row to Los Angeles, including four straight at MSG. They fell 99-82 in Los Angeles on Dec. 29, when Lin scored two points in 1:40 of playing time.
Bryant, the league leader with 29.2 points per game, has averaged 33.4 points during the Lakers' nine-game winning streak in this series. He's averaging an incredible 40.0 points in his last four visits to New York, including a 33-point effort in a 113-96 victory last Feb. 11.
Teammate Pau Gasol had 25 points, 14 rebounds and two blocks Thursday as the Lakers won 88-87 in overtime at Boston. One of the blocks came at the final buzzer to secure the victory.
"I've been in situations before in my career where you freeze … catch yourself looking at the ball and end up losing the game," Gasol said.
Gasol is averaging 26.8 points and 9.0 rebounds in his last four road games against the Knicks.


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Sunday, November 29, 2020
"Our problem is occupation": reactions to Trump's declaration in Jerusalem
The Palestine Monitor
- December 21, 2017
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A few days after US President Donald Trump's speech recognising Jerusalem as the capital of Israel, life in the Old City of Jerusalem seemingly carried on as normal. Tourists and pilgrims wandered around the shops selling local artisanal products and religious souvenirs in the souk's winding and damp alleys.
This part of the city is located in East Jerusalem, internationally recognised as under Israeli occupation. The green line, which marks Israel's borders prior to the 1967 war, runs not far from here.
UN resolutions and the international community do no recognise Israel's unilateral annexation and declaration of Jerusalem as its "unified capital" in 1980. No state has its embassy in the city, although some have diplomatic representations in East Jerusalem. Under pressure from part of his constituency, Trump announced the US will also begin the process of moving its embassy there from Tel Aviv, making it the first state to do so.
For Palestinians, who claim the eastern part as the capital of their future state, the move amounts to a de-facto legitimisation of Israel's annexation. The status of Jerusalem is one of the thorniest points in the conflict. It was left unresolved in the interim Oslo Accords signed in 1993 and 1995, and its fate was to be determined in peace negotiations. Negotiations which have been going nowhere since.
The Palestinian leadership reacted with strong words to the announcement, saying it would signal the end of any possibility for a two-state solution and disqualify the US, which has been leading the peace process, as an "honest broker". Both Fatah and Hamas, the two main Palestinian political parties, called on people to take to the streets in protest. But demonstrations have been rather top-down and so far failed to draw the masses out onto the streets.
Despite that, clashes between Palestinian youth and Israeli forces continue across the West Bank, Gaza and Jerusalem neighborhoods almost on a daily basis. Last weekend only, four Palestinians died in Gaza and the West Bank. Hundreds have been injured and arrested since protests began.
Rami, 29, who owns a flower shop near Damascus Gate, said he didn't think the declaration would dramatically change things for Palestinians in East Jerusalem.
"We are under occupation," Rami said. "The problem with the declaration is that it says we are not," he said.
Deeper into the Old City, Mumtaz, who owns a souvenir shop, like many others was initially reluctant to talk about Trump's declaration.
"Trump had a problem inside his government and with Russia, that's why he decided to do this," he began.
"For us Palestinians, we cannot build, work or earn money under occupation. If we work, we get paid less," he argued. The Israeli government rarely issues building permits to Palestinians in East Jerusalem, who are sometimes forced to demolish their own homes to avoid incurring huge fines to take down what the municipality considers illegal construction.
"Our problem is occupation, not religion. But they want to make it that," he added.
On talking to Jewish Israelis on the streets of Jerusalem, it appears to be almost evenly split when asked if they support US President Donald Trump's declaration of Jerusalem as the capital of Israel. Jewish Israeli reactions range from; "Israel was God given, a gift to the Jewish, [so] Jerusalem is only for the Israeli government," as 39 year old Orthodox Jew, Avi Samat expressed, to: "I don't think America's recognition should mean anything to us, it's only added tension," as 32-year-old Smadar Regev said, worried about potential clashes near her home.
Sixty- five year old Nehenia Ashkenzy agrees with the White House, but somewhat contradicts himself in also believing the east side is for Palestinians. "Maybe the Wailing Wall, it belongs us (the Jews), after the wall it's theirs," Ashkenzy said. "All the people talk about Jerusalem like it's this side and this side, not together," he continued, motioning with his hands. "But when we have peace, Jerusalem is Jewish, besides the Palestinians," Ashkenzy emphasised the East side is for Palestinians, though not completely realising the Wailing Wall falls on the eastern side.
The majority of Jewish Israeli citizens Palestine Monitor spoke to do not seem to support the US statement. Most would prefer the capital split, the West for Israelis and the East for Palestinians, including the old city.
24-year-old Eden feels like she doesn't have a connection to the East Jerusalem. "A big part of Jerusalem, East Jerusalem, we don't really know, it's two cities in one city, that's how it feels. I believe they [the Palestinians, can have that side] and we can live together in harmony and peace," Eden said.
Others stressed the possibility of living in a unified capital. "East Jerusalem, I don't feel like it's my capital. The capital is here," industrial design student Yarin Ariv said as he stood in Mahane Yehuda Market in West Jerusalem. "But because we aren't just Jewish in our country, maybe [the capital] should be the whole city," Ariv concluded.
Batsheva Shamama, a history teacher born in Jerusalem, said she knew the facts; "Jerusalem is the capital of Israel. It could be divided, but only if the Palestinians really want real peace. They could have had part of Israel and part of Jerusalem, but they don't want us (the Jews) here at all," Shamama said, referring to the 1947 UN Partition Plan the Arab world rejected.
Back in East Jerusalem, 40-year-old Samer from Beit Hanina, who owns a store selling beauty products near Damascus Gate, responds to the well-known mantra:
"They are making a fool out of everyone in the world [with the declaration]. The peace process is also not good. Not that I am not with the peace. I'm with peace but not in this way," Samer said.
He points out that while negotiations stalled, Israel has been building more settlements, including in East Jerusalem, while Palestinians continue to live under a system of discrimination.
"The ID card we have, has an expiry date," he said referring to the blue ID most East Jerusalemites hold. They are not citizens of Israel but became "permanent residents" after annexation. This status, however, is dependent on Palestinians continually proving their connection to the city. More than 14,000 East Jerusalemites have seen their residency revoked since 1967.
"If foreigners take a permission to come here, they have a permission to stay for some time. For us it's the same. Maybe when we go renew it, they tell us no, we will not give you your ID. We are the Palestinian people not from today, from a long time ago," Samer said.
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This Cardinals quick snap scrapper mat is the perfect outdoor mat for the Arizona Cardinals fan that has everything and wants something new. Made using a graphic design that is the reusult of an NFL design contest, this outdoor doormat is very tough and durable and features a truly unique look. Made with heavy duty rubber here in the US, this mat is perfectly suited for outdoor use.. One of the distinguishing features of this doormat is its' raised "scrapper nibs" that act as an aggressive scrapping surface for your guests' shoes. In addition the nibs create "natural" channels and reservoirs that help to trap and hold water and other debris on the mat instead of being tracked onto your floors. As it is crafted out on rubber with a smooth rubber backing this mat will not slip around and can withstand the rigors of outdoor use. Care of the mat itself is also very easy as all you need to do is hose it off, sweep it off or shake it out and if damp let it air dry.
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Undefested heavyweight prospect Daniel Cormier (7-0 MMA, 4-0 SF) will get his stiffest career test to date when he faces 14-year veteran Jeff Monson (42-11 MMA, 0-0 SF).
Strikeforce officials recently announced the matchup, which takes place June 18 at "Strikeforce: Overeem vs. Werdum."
Featuring a pair of quarterfinal bouts in Strikeforce's heavyweight grand prix, "Strikeforce: Overeem vs. Werdum" takes place at American Airlines Center in Dallas and airs on Showtime.
Cormier made his pro debut in September 2009 under the Strikeforce banner. The former two-time Olympian has since fought three more times for the promotion, including a unanimous decision win over Devin Cole this past January.
With six stoppage wins in seven career fights, Cormier has picked up titles on the regional circuit in both the King of the Cage and Australian-based Xtreme MMA promotions.
Meanwhile, Monson carries an eight-fight win streak into the matchup. A veteran of the DREAM, Sengoku and PRIDE organizations, "The Snowman" also fought seven times for the UFC, including a November 2006 heavyweight title shot against Tim Sylvia. Monson lost via unanimous decision in a lackluster five-rounder, and he was promptly released from the promotion.
The American Top Team-trained Monson owns 26 of his 42 career wins via submission.
For more on "Strikeforce: Overeem vs. Werdum," stay tuned to the MMA Rumors section of the site.
(Pictured: Daniel Cormier)


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The Congregation for Clergy published an examination of conscience entitled "The Priest, Minister of Divine Mercy: An Aid for Confessors and Spiritual Directors" which hopes to reinvigorate the priest's spiritual paternity by a recovery of the sacrament of Confession by penitent and confessor. Here is yet another aspect of the new evangelization called for by Blessed John Paul II and now Pope Benedict: the renewal of priests and people through Reconciliation. This document is the fruit of Pope Benedict's Year for Priests. As Cardinal Piacenza notes, this "is a measure of authentic faith in the saving action of God which shows itself more clearly in the power of grace than in human strategic or pastoral initiatives which sometimes overlook this essential truth." A sobering statement for one who works in a parish.
On the surface it seems that this text is exclusively for the clergy. Don't be fooled! I would recommend it to the laity as well. Be acquainted to the sacrament of Confession, the theology and practice of the Church and what the Church expects of her clergy. We have to help each other see Christ's work among through concrete manifestation of Divine Mercy.
The introduction follows here (the link to the full text is at the end):
"It is necessary to return to the confessional as a place in which to celebrate the Sacrament of Reconciliation, but also as a place in which "to dwell" more often, so that the faithful may and compassion, advice and comfort, feel that they are loved and understood by God and experience the presence of Divine Mercy beside the Real Presence in the Eucharist".
With these words, the Holy Father Pope Benedict XVI addressed confessors during the recent Year for Priests, indicating to each one present the importance and therefore the apostolic urgency of rediscovering the Sacrament of Reconciliation, both from their viewpoint of penitents as well as that of ministers. Along with the daily celebration of the Eucharist, the availability of the priest to hear sacramental confessions, to welcome penitents, and to accompany them spiritually when they so request, is the real measure of a priest's pastoral charity. By their availability, priests give joyful witness and in a certain sense take upon themselves their true identity, redefined in the Sacrament of Holy Orders and not reducible to a mere functionality. The priest is a minister, which is to say that he is at the same time both a servant and a prudent dispenser of Divine Mercy. To him is entrusted the serious responsibility "to forgive or to retain sins" (cf. John 20: 23).
Through him, and through the power of the Spirit who is the Lord and Giver of Life, the faithful are able to experience today in the Church the joy of the Prodigal Son, who after a life of sin returned to his father's house in the manner of a servant but was welcomed with the dignity of a son. Whenever a confessor is available, sooner or later a penitent will arrive. And if the confessor continues to make himself available, even stubbornly so, sooner or later many penitents will arrive! Our rediscovery of the Sacrament of Reconciliation, both as penitents and as ministers, is a measure of authentic faith in the saving action of God which shows itself more clearly in the power of grace than in human strategic or pastoral initiatives which sometimes overlook this essential truth.
Responding to the appeal of the Holy Father and expressing his profound intent, this aid is intended as yet another fruit of the Year for Priests, to be a helpful instrument for the ongoing formation of the Clergy and an aid in rediscovering the indispensible value of the Sacrament of Reconciliation and of Spiritual Direction. The new evangelization and the ongoing renewal of the Church, semper reformanda, draw their life blood from the true sanctification of each member of the Church. It is clear that sanctifi cation must precede both evangelization and renewal, for it lays claim to and forms the necessary precondition for every effective apostolic effort, as well as for the reform of the Clergy.
In the generous celebration of the Sacrament of Divine Mercy, each priest is called to experience for himself the uniqueness and the indispensability of the ministry entrusted to him. Such an experience will help him to avoid the "ever-changing sense of identity" which so often marks the existence of some priests. Instead, his experience will cultivate within himself that sense of wonder which fi lls his heart, for through no merit of his own he is called by God, in the Church, to break the Eucharistic Bread and to forgive the sins of others.
The document: "The Priest, Minister of Divine Mercy: An Aid for Confessors and spiritual Directors": Examination of Conscience for confessors and spiritual directors.pdf


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http://mmajunkie.com Bellator officials are close to naming a date and venue for a season-five title fight between welterweight champion Ben Askren (8-0 MMA, 5-0 BFC) and recent tournament winner Jay Hieron (22-4 MMA, 3-0 BFC).
And if officials get their way, it'll take place on the campus of the University of Missouri, where Askren won two NCAA Division I national wrestling championships.
But as Bellator CEO Bjorn Rebney recently told MMAjunkie.com (www.mmajunkie.com), there could be some hurdles.
"It really just boils down to whether or not Mizzou has the availability and the venue," said Rebney, who's been in talks with officials from the Columbia, Mo. university. "I think it's the kind of show in that market with its attachment to wrestling, it could do spectacular. Obviously, there would be tremendous, over-the-top support for Ben. But it's just finding a date there."
A rumored Oct. 8 date at Bellator 53, though, isn't happening, Rebney said.
"All indications are that the fight will take place at the end of October," he said. "If not the end of October, definitely the beginning of November."
The preference is to do at the University of Missouri, though Rebney may need to hold it elsewhere.
"We're just trying to find the right location for that," he said. "Mizzou would be great, but I don't know if we can pull it off given the availability."
In addition to Askren, Mizzou has produced wrestlers-turned-MMA-fighters such as Michael Chandler (who's got an upcoming title fight with Bellator lightweight champ Eddie Alvarez), top Strikeforce contender Tyron Woodley, Bellator vet J.P. Reese and ProElite heavyweight Mark Ellis.
As for Askren, who's 8-0 since 2009 pro debut, Rebney said he's just anxious to get back in the cage.
"He would fight every four or six days if he could get away with it," Rebney said. "He's ready to go at any moment. He's one of the guys hitting me up all the time saying, 'I'm ready to go.'"
For more on Bellator's upcoming season, stay tuned to the MMA Rumors section of the site.
(Pictured: Ben Askren)


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A new release of Microsoft All-In-One Code Framework is available on April 16th. This blog introduces 14 ASP.NET and Azure code samples in the release. The rest new samples will be introduced next week.
Download address: http://1code.codeplex.com/releases/view/64551
Alternatively, you can download the code samples using Sample Browser v3. The new Sample Browser gives you the flexibility to search samples, download samples on demand, manage the downloaded samples in a centralized place, and automatically be notified about new releases.
If it's the first time that you hear about Microsoft All-In-One Code Framework, please read this Microsoft News Center article http://www.microsoft.com/presspass/features/2011/jan11/01-13codeframework.mspx, or watch the introduction video on YouTube http://www.youtube.com/watch?v=cO5Li3APU58, or read the introduction on our homepage http://1code.codeplex.com/.
CSAzureWorkflowService4, VBAzureWorkflowService4
CSAzureWorkflowService4: http://code.msdn.microsoft.com/CSAzureWorkflowService4-2519c571
VBAzureWorkflowService4: http://code.msdn.microsoft.com/VBAzureWorkflowService4-62a20440
This sample demonstrates how to run a WCF Workflow Service on Windows Azure. It uses Visual Studio 2010 and WF 4. While currently Windows Azure platform AppFabric does not contain a Workflow Service component, WCF Workflow Services can be run directly in a Windows Azure Web Role. By default, a Web Role runs under full trust, so it supports the workflow environment.
The workflow in this sample contains a single Receive activity. It compares the service operation's parameter's value with 20, and returns "You've entered a small value." or "You've entered a large value.". The client application invokes the Workflow Service twice, passing a value less than 20, and a value greater than 20.
CSASPNETReverseAJAX, VBASPNETReverseAJAX
CSASPNETReverseAJAX: http://code.msdn.microsoft.com/CSASPNETReverseAJAX-7a1f0c2b
VBASPNETReverseAJAX: http://code.msdn.microsoft.com/VBASPNETReverseAJAX-321a68b0
Reverse Ajax is also known as Comet Ajax, Ajax Push, Two-way-web and HTTP server push. This technique persists a HTTP request to allow the server push data to a browser, without requesting the server in an individual time. This sample shows how to use this technique in ASP.NET Ajax.
CSASPNETAutoLogin, VBASPNETAutoLogin
CSASPNETAutoLogin: http://code.msdn.microsoft.com/CSASPNETAutoLogin-25cfae2b
VBASPNETAutoLogin: http://code.msdn.microsoft.com/VBASPNETAutoLogin-023c5ab4
The code sample demonstrates creating an ASP.NET web application that supports user login using HttpWebRequest Class without manually filling out username and password textboxes. In the code sample, the Login.aspx page implements the normal login, and the AutoLogin.aspx page implements the programmatic login.
Download: http://code.msdn.microsoft.com/VBASPNETInfiniteLoading-10c3f379
Infinite scroll, has also been called autopagerize, unpaginate, endless pages. But essentially it is pre-fetching content from a subsequent page and adding it directly to the user's current page. The code sample demonstrates loading a large number of data entries in an XML file. It support infinite scroll with the AJAX technology.
CSASPNETLimitDownloadSpeed, VBASPNETLimitDownloadSpeed
CSASPNETLimitDownloadSpeed: http://code.msdn.microsoft.com/CSASPNETLimitDownloadSpeed-819f5d04
VBASPNETLimitDownloadSpeed: http://code.msdn.microsoft.com/VBASPNETLimitDownloadSpeed-fe1dc09a
This project illustrates how to limit the download speed via coding. If you have installed IIS 7.0 we strongly recommend you use the Bit Rate Throttling feature instead of what this code sample demos to limit the download speed. Please refer to http://www.iis.net/download/BitRateThrottling.
CSASPNETServerClock, VBASPNETServerClock
CSASPNETServerClock: http://code.msdn.microsoft.com/CSASPNETServerClock-23c659d4
VBASPNETServerClock: http://code.msdn.microsoft.com/VBASPNETServerClock-aff6fbca
This project illustrates how to get the time of the server side and show it to the client page. Sometimes a website needs to show a unified clock on pages to all the visitors. However, if we use JavaScript to handle this target, the time will be different from each client. So we need the server to return the server time and refresh the clock per second via AJAX.
If you have any suggestions for the code samples, please email us: email@example.com.


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Medical Device Market Opportunities In Italy, 2012
20 Nov, 2013, 17:55 GMT
DUBLIN, Ireland, November 20, 2013 /PRNewswire/ --
Research and Markets (http://www.researchandmarkets.com/research/7g9kd2/medical_device) has announced the addition of the "Medical Device Market Opportunities In Italy, 2012" report to their offering.
(Logo: http://photos.prnewswire.com/prnh/20130307/600769 )
Medical Device Market Opportunities in Italy, 2012 quantifies, analyzes, and forecasts the trends and opportunities in the Italian medical devices market. The report provides a complete roadmap and essential data for current and hopeful competitors selling medical devices and products in Italy. Historical data covers 2007-2010, most recent actual year data is for 2011, and forecasts extend through 2014.
Coverage in This Report:
- Key Population Data, Trends, Indicators (2007-2014)
- Key Economic Data, Trends, Indicators (2007-2014)
- Key Healthcare Data, Trends, Indicators (2007-2014)
- Clinical Indicators & Statistics, by Segment (2007-2014)
- Disease Incidence & Prevalence Statistics, by Segment (2007-2014)
- Barriers to Entry for Medical Product Companies
- Regulatory Overview, Challenges and Path
- Channel Analysis & Potential Sales Models (Distributor, Direct, Hybrid, Other)
- Emerging Trends, Opportunities, and Market Outlook (2007-2014)
- Surgical Procedure Volumes, by Segment (2007-2014)
Questions Answered in This Report
- What are the key population, economic and healthcare data and trends that a medical device manufacturer needs to know to be competitive in Italy?
- What are the disease incidence & prevalence data? What are the future trends? What do current and emerging patient caseloads look like? Where are the opportunities?
- Procedure volumes and growth differ dramatically within the different therapeutic areas in Italy. What is the volume of surgical procedures currently being performed in each therapeutic area? What are the growth trends? Where are the procedures being performed?
- What is the regulatory path for getting a medical device approved in Italy? What other market barriers or challenges exist?
- How does a medical product company access this market? What are the sales models -- distributor, direct sales force, hybrid, other?
- What other challenges and opportunities exist in Italy for current and hopeful market participants?
For more information visit http://www.researchandmarkets.com/research/7g9kd2/medical_device
Research and Markets
Laura Wood, Senior Manager.
U.S. Fax: 646-607-1907
Fax (outside U.S.): +353-1-481-1716
Sector: Medical Devices
SOURCE Research and Markets


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Areas of Research
The Department of Cell Biology comprises a dynamic and interactive group of faculty members, postdoctoral associates and fellows, research scientists and graduate students. Our primary facilities are located at the School of Medicine and at Yale's West Campus.
Our field is developing rapidly at areas of interface between conventional molecular cell biology of single cells and more complex cellular systems at one extreme, and at the interface with protein structure and molecular mechanism at the other. We maintain a high level of capability in electron microscopy, including immunocytochemistry and tomography; in conventional optical microscopy at our Center for Cell & Molecular Imaging (CCMI), which performs state of the art electron microscopy and immunocytochemistry, as well as routine single and multi-photon confocal microscopy; and the CINEMA Lab, a world leader in the development of new optical techniques for live cell imaging and quantitative analysis.


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Overall Rating
This updated and enhanced sixth edition of ESSENTIALS OF METEOROLOGY is written by the widely read and authoritative author in introductory meteorology--Donald Ahrens. Ahrens's ability to explain relatively complicated ideas in a student-friendly, manageable fashion will allow you to easily visualize the principles of meteorology. ESSENTIALS OF METEOROLOGY is completely updated with over 250 new images and figures and the latest research and coverage.
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text: Peaks at Pine Bluff apartment homes are located in a well-established neighborhood that offers a unique combination of upscale amenities and affordability. Developed with careful attention to functional layout and design, the community supports the needs of all age groups. Come and enjoy the long list of exterior/interior finishes and friendly staff that await you.


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IUSM ReSEARCH Connect is an important and innovative tool that enables IUSM researchers to identify new funding opportunities and potential collaborators within academia, industry, and the broader health sciences community. This exciting resource serves to help investigators develop "bench-to-bedside" studies and foster novel areas of investigation, leading to strong translational and clinical applications. IUSM ReSEARCH Connect is an essential mechanism in promoting Indiana University and its clinical partners Indiana University Health, Eskenazi Health, and the Roudebush VA Medical Center as national and international leaders in biomedical research and patient care.
Collaborations and top research areas from the last five years
Click dots and donuts to bring up details.


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Apt: Guns & Robots Will Feature Customisable Gunfighters
Bulgarian studio Masthead didn't have a lot of luck with their ultra-ambitious MMO, Earthrise (which was a wonky attempt a free-roaming sci-fi shooter MMO, with elements from Eve and Tabula Rasa), which sadly closed earlier in the year. They've got a second shake of the stick though, and that's going to be a free-to-play shooter called Guns & Robots. The forthcoming game is all about robot customisation (which is detailed in an video you can watch below) which offers a vast range of possibilities for tweaking and altering your bot. It's got a Wild West setting to it, so that wandering robot gunfighters will be facing each other down at high noon. It might just work. I've also posted the concept teaser below, for your perusal.


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iPhone 8 Plus - iOS 14
Mobile phone
Resetting to factory settings
* A factory reset will restore your Apple iPhone 8 Plus to its original settings. * *Note:* A factory reset will delete your personal data and settings including contacts and photos. Back up your data to prevent losing files or contacts before you do a factory reset.
* Go to the Start screen. * Choose *Settings*.
* Scroll down. * Choose *General*.
* Scroll down. * Choose *Reset*.
* Choose *Erase All Content and Settings*.
* Choose *Erase iPhone*.
* Choose *Erase iPhone*.
* All data and settings saved on the Apple iPhone 8 Plus will be deleted. * The Apple iPhone 8 Plus will automatically reset and reboot.
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Welcome to the AFA Media Center. Please click on any of the options below to start exploring the amazing world of A Foreign Affair and International Dating
By: Amber Brooks, Contributing Editor, DatingAdvice.com
The Short Version: Building a relationship with someone overseas becomes much easier when you have a trusted dating service supporting you every step of the way. Over the last two decades, A Foreign Affair has provided thousands of singles with the resources to meet attractive dates in Eastern Europe, Latin America, and Asia. This international dating agency has run a hands-on service that gives men the best possible chance of finding romance in a foreign country. By organizing group tours and offering VIP consultations, A Foreign Affair has made distance a non-factor in the search for love and marriage.
International dating can get a bad rap in the industry. A few bad apples generate headlines and public outrage, which makes the entire system seem corrupt when it's more of a mixed bag. Although many sketchy sites and services exist out there, singles can also find a fair share of well-intentioned teams trying to bring people from different backgrounds together.
Most people make assumptions about international dating services without looking into what the company does and how the system actually works. If they'd only dig a little deeper, they could be surprised by what they find.
A Foreign Affair has run over 500 singles tours in foreign countries since its founding in 1995. Single men may want to take a closer look at A Foreign Affair, which is a longstanding international dating service with a transparent matchmaking process. Since 1995, this company has united thousands of singles and become a leader in transcontinental dating.
The hands-on team conducts European, Latin American, and Asian tours to facilitate introductions between Western men and local women. A Foreign Affair has over 300 affiliated offices around the world, so it definitely has the resources to connect relationship-minded singles with desirable dates in dozens of countries.
The company's President, John Adams, told us international dating is slowly losing its stigma, and A Foreign Affair has seen its client base increase as a result.
"We're getting more and more mainstream,"" he said. "We see the stigma changing every day as the world continues to get smaller."
In the last few years, A Foreign Affair has implemented a comprehensive Executive Plan that helps clients at every stage of the dating process, particularly in preparing singles for the dating journey ahead. This unique service gives singles everything they need to build confidence, find dates, and make a long-term match.
A Foreign Affair partners with professional dating coaches to provide image and wardrobe consultations to men seeking international romance. "It's a dating tune up," John explained. "Basically, we get him ready to go so he can actually be successful with everything we're going to do for him as far as introductions."
The team of dating experts takes the time to understand who their clients are and what they want. The goal is to ensure that person is mentally, emotionally, and physically prepared to meet women in another country and build authentic relationships. Then they put together photos, a dating profile, and a marketing package to show to women abroad. A personal consultant walks the client through the process and answers any questions or concerns along the way.
"With our service, you have someone who's going through this whole dating process with you. They're giving you a lot of advice."
John Adams, President of A Foreign Affair
A Foreign Affair streamlines international dating by arranging about a dozen introductions, offering feedback, and providing translators. The team has decades of experience building relationships between people across vast distances and can help clients present themselves properly via letter, Skype, or in person.
By emphasizing dating readiness in the early stages of the process, A Foreign Affair puts clients in a position to take full advantage of the romantic opportunities to come.
"The Executive Plan is a very in-depth, very thorough, very personalized, very focused approach," John said. "It's not for the faint of heart because there's a lot that goes on with this."
Since the beginning, A Foreign Affair has led group tours that give men a chance to be pursued by beautiful women. In a recent event in Kiev, John told us the company had about 490 Ukrainian women competing to talk to 30 men. It was a confidence-boosting experience for the clients, many of whom had never been in that position before.
The group tours put clients in front of as many women as possible during a trip to Eastern Europe, Latin America, or other parts of the world. On average, clients meet 500 to 2,000 women during a series of tour socials that last up to two weeks. The process isn't as targeted or as personalized as the Executive Plan, but it does offer a time-efficient way to get into the international dating scene. Singles can join a group tour to take control of their love lives and meet attractive date prospects throughout the world.
A Foreign Affair takes a holistic approach to its dating services, endeavoring to help clients not only meet someone but feel better about themselves. It's a lot of work, but it pays off when the client can show up on dates as the best version of himself.
"It helps in all aspects of life. It's not just the dating part. It gives them more confidence. It makes them better business people because they feel more confident about themselves," John said. "All the different things we work with them on helps them in so many ways."
A Foreign Affair has received stellar feedback from former clients. Its success stories speak to the effectiveness of its matchmaking process.
Jeff and Olga fell in love while writing letters and enjoying lengthy phone conversations with one another. Meeting in person in Paris was just a confirmation of everything they felt. "We both spent the best week of our lives there," said Jeff. "At the end of the trip, I asked her to marry me." Today, the married couple live together in the US.
Another client, Trevor J., said he'd never received so much attention from around the world before. "I breaks my heart that I just can't respond to them all," he said.
"A Foreign Affair has not made any promises to me they have not kept." - Michael, an AFA client
"Wow I loved the tours!" wrote Wayne in a positive review. "I want to go again. I learned so much and sincerely cherished the opportunity to meet so many wonderful women. I would gladly recommend AFA and their tours to my single buddy friends. If they are truly serious about finding a life mate, this is the way to go and the company to use."
"AFA is the only company that lives up to its reputation as an international introduction agency," said Gary. "It is not enough to collect millions of dollars from lonely men. A company must be positioned to actually help. AFA does exactly that."
"The beautiful part of the Executive Plan is it doesn't focus on geography," John said. "Geography is no longer a boundary, so it doesn't matter if she lives in Russia, Colombia, Peru, or China. We can find the best candidates in the world, no matter where they are."
If you're in a dating rut, it may be worthwhile to explore your options overseas. A Foreign Affair provides an exemplary international dating service rooted in personalization, accountability, and time-tested expertise. This company stands out from its less savory competitors by providing supportive services that help men understand what's expected of them and how to get the relationship they want.
Since 1995, A Foreign Affair has endeavored to lower the barriers between international daters and encourage singles to fall in love across vast distances.
"The world is so small now, it just makes no sense to limit yourself to one city or one country when it comes to finding a match," John said. "We've been saying that for 23 years now, and we'll continue to do so."


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A naturally superior bath: It may sound obvious, but not all baths are created equally. At Victoria + Albert we are passionate about our unique QUARRYCAST™ material.
QUARRYCAST™ is made from finely ground Volcanic Limestone™ mixed with resin. As the stone-rich alternative to both cast iron and acrylic it is 100% one piece, hand finished and packed with naturally desirable properties:
Warm Due to the quality of the QUARRYCAST™ material it has high insulation properties and is warm to the touch
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Volcanic Limestone ™ is Victoria + Albert's proprietary name for the very special white rock that is perfect for making baths and basins.
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Victoria + Albert blends milled Volcanic Limestone™ with high quality resins to bind these strands into a complex 3D matrix.
The finished result is QUARRYCAST™ – a world class composite with an exceptional strength to weight ratio.


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It's no secret I'm a big fan of Jaguar Design production studio director Wayne Burgess. I think he's a really talented designer, and, more importantly, has indulged my awful ideas on several occasions. Also, he's had a great collection of crappy/wonderful cars. And he likes to talk about them, as you'll see.
Wayne sat down with me and talked about the design of the New F-Type coupé, the appeal of classic sports car proportions, a Fiat 128 covered in Hammerite, designing a London Cab, commenting on a drawing of a V8 Singer Stiletto, and more. All while sketching a really lovely and precise drawing of an F-Type Coupé.
So, if you can forgive that I pronounced "coupé" as "cou-pay" and "coup" interchangably and fumbled the camera at least once (I do these very informally and don't use a monopod or tripod either, so, sorry in advance), I think you'll find this chat pretty engaging.


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Gulf Coast Hurricane Tracker
A single source reference on tropical weather predictions. With a traditional focus on the upper Texas and Louisiana Gulf Coast we've maintained links to track all Atlantic Basin, Caribbean and eastern Pacific storm systems. We are now expanding our view to tropical storms throughout the world intending to be a comprehensive global storm tracking resource.


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Former Utah State University President Stanford O. Cazier has died. News of his death was announced Thursday, March 14. President Cazier led the university during more than a decade of growth and expansion.
"We are saddened to learn of the death of our friend and former president Stan Cazier," said current USU President Stan Albrecht. "He will be remembered first as a popular history professor by many. As president, he was on hand to lead the university's centennial celebration. His contributions to Utah State University were many."
Cazier became USU's 12th president following the retirement of Glen L. Taggart in 1979. He had previously served as an assistant to President Taggart prior to becoming president of California State University, Chico, in 1971.
He began his teaching career at USU in 1960 as an assistant professor of history. He was named Teacher of the Year in 1966. After earning his doctorate from the University of Wisconsin, he was named head of USU's History Department, but in 1967 he took a leave from Utah State to become an American Council on Education Fellow in academic administration at New York University. There, with the support of a Ford Foundation Fellowship, he worked as an administrative intern and assistant to the president of the university. He returned from New York University to again serve as an assistant to President Taggart, while also serving as assistant provost and department head.
"Professor Cazier gained a reputation as the premier teacher because of his capacity as a lecturer," said Ross Peterson, a former student and later a colleague at USU. "His classes were amazingly dramatic, challenging and rewarding. I had the privilege of having five classes with him, and he convinced me to become a professor. However, I remember him more for how much he helped people. When the east winds blew trailers over in the fall of 1964, he led the faculty in raising money to help the students. His entire mode of operation was to provide opportunities for students."
In 1971, he left Utah State to become president of California State University, Chico, where he served for eight years, then returned to Utah as Utah State University's president in 1979. Following his retirement in 1991, the Cazier Science and Technology Library was named in his honor. That facility is now a part of the Merrill-Cazier Library at USU. Additionally, he was a member of the Old Main Society.
At the time of his retirement, The Deseret News published an overview of Cazier's time as USU's president.
"Cazier has been a staunch defender and advocate of USU, traveling constantly to promote the school's interests and tirelessly making known his conviction that the Logan-based institution 'is a finer university than most people in Utah realize,'" the Deseret News wrote. "Certainly, much of what the school has become can be attributed to Cazier's leadership since he took office in June 1979. During his tenure, enrollment has grown by 50 percent; private giving for scholarships, facilities and programs has increased three-fold; several new buildings have been constructed on campus; new distance-learning programs have been started to teach classes at sites scattered throughout Utah and a number of new on-campus education programs have been implemented."
Following his retirement he returned to the classroom where he remained a full time professor until 1997. Since then, he continued to teach classes as a professor emeritus.
A native of Nephi, Utah, Cazier earned an undergraduate degree from the University of Utah in 1952, where he also earned a master's degree in 1956. He earned his doctorate in history, studying under the well-known historian Merle Curti at the University of Wisconsin. He taught one year at the Bronx Community College before joining the faculty at USU. He married Shirley Anderson, who was known as a gracious and popular first lady at Utah State University. She died Feb. 16, 1999.


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Motorola debuts new, cheaper smartphone
Unveiled Wednesday at a special event in Sao Paulo, Brazil, Motorola's Moto G, a premium smartphone handset with an entry-level price, will retail for just $179 without a contract, yet offers specs that will give most mid-tier handsets serious competition.
As well as a 720p 4.5-inch display, which Motorola claims offers an as good if not better viewing experience as the latest iPhone, the Moto G comes with Android 4.3 pre-installed - and will be getting the 4.4 KitKat upgrade in January - and is powered by a quad-core processor.
Motorola says that the purpose of the handset is to provide consumers in emerging markets with an affordable alternative to handsets such as the Samsung Galaxy SIV but without robbing them of the full potential of Android and its apps ecosystem.
And while the company chose Brazil for the handset's launch, the phone will not be confined to Latin America. It will also be launching in Europe and Asia in time for the holiday season.
During the launch Motorola CEO Dennis Woodside said the company was setting its sights on the world and that half a billion people deserve better, referring to the poor quality handsets currently available to those unable or unwilling to spend more than $200 on a phone.
As such the company has made sure the Moto G boots and responds faster and more smoothly than anything in its price range and many devices beyond it, including the Galaxy SIV. One of the reasons the phone is so fast and responsive and offers all-day battery life (which equates to up to 14 hours of talk time) is because it does away with built-in apps or skins.
The Moto G will run pure unaltered Android but, like its big brother, the Moto X, which was launched exclusively in the US in August, the exterior is up for customization and users will be able to specify different shells and buy protective covers to accessorize their handsets.
As well as the 8GB version, which will cost $179 off contract, Motorola will also offer a 16GB version for $199. But on top of that it will also be offering free cloud storage and in some markets, dual SIM versions, but the handset does not support 4G or LTE networks.


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CALGARY, ALBERTA–(Marketwired – Oct. 8, 2015) – AltaGas Ltd. ("AltaGas") (TSX:ALA) will release its 2015 third quarter financial results on Thursday, October 29, 2015. A conference call and webcast will be held the same day to discuss the financial results, progress on construction projects and other corporate developments.
Time: 9:00 a.m. MT (11:00 a.m. ET)
Dial-in: 416-340-2218 or toll free at 1-866-225-2055
Webcast: http://altagas.ca/investors/presentations_and_events
Shortly after the conclusion of the call, a replay will be available by dialing 905-694-9451 or 1-800-408-3053. The passcode is 1022285. The replay will expire at midnight (Eastern) on November 5, 2015. The webcast will be archived for one year.
AltaGas is an energy infrastructure business with a focus on natural gas, power and regulated utilities. AltaGas creates value by acquiring, growing and optimizing its energy infrastructure, including a focus on clean energy sources. For more information visit: www.altagas.ca
This news release contains forward-looking statements. When used in this news release, the words "may", "would", "could", "will", "intend", "plan", "anticipate", "believe", "seek", "propose", "estimate", "expect", and similar expressions, as they relate to AltaGas or an affiliate of AltaGas, are intended to identify forward-looking statements. In particular, this news release contains forward-looking statements with respect to, among other things, business objectives, expected growth, results of operations, performance, business projects and opportunities and financial results. These statements involve known and unknown risks, uncertainties and other factors that may cause actual results or events to differ materially from those anticipated in such forward-looking statements. Such statements reflect AltaGas' current views with respect to future events based on certain material factors and assumptions and are subject to certain risks and uncertainties, including without limitation, changes in market, competition, governmental or regulatory developments, general economic conditions and other factors set out in AltaGas' public disclosure documents. Many factors could cause AltaGas' actual results, performance or achievements to vary from those described in this news release, including without limitation those listed above. These factors should not be construed as exhaustive. Should one or more of these risks or uncertainties materialize, or should assumptions underlying forward-looking statements prove incorrect, actual results may vary materially from those described in this news release as intended, planned, anticipated, believed, sought, proposed, estimated or expected, and such forward-looking statements included in, or incorporated by reference in this news release, should not be unduly relied upon. Such statements speak only as of the date of this news release. AltaGas does not intend, and does not assume any obligation, to update these forward-looking statements. The forward-looking statements contained in this news release are expressly qualified by this cautionary statement.
AltaGas Ltd.
Investment Community
AltaGas Ltd.
(403) 691-7197


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By Gina Hall
Gina Hall is a Los Angeles-based writer. Follow her on Facebook.
[Bio Cont'd Below…]
The third year of the Produced By Conference brought more than 2,200 people to the Disney lot in Burbank on June 4th and 5th. There was no shortage of star-powered panels and discussions on "green content" but the focus ultimately centered on emerging digital technology. The hope is that digital technology can usher in a more sustainable era to the industry by reducing our print and production materials and changing the distribution model from one that requires delivery of a print to one that is beamed into the theater or home.
Highlights of the conference included the Bleeding Green: Content with a Cause panel, which featured a conversation on developing documentary material with a green agenda. Panelists included Lesly Chilcott, producer of Waiting For 'Superman' and An Inconvenient Truth, and Fisher Stevens, producer of The Cove.
Again, the focus centered on how digital media has become the biggest asset to the "green filmmaker" in all areas; financing, raising awareness, filming and distribution. Twitter, Facebook and blogs have become the go-to method for finding an audience and online channels plus Netflix a preferred distribution outlet. The glut of eco-content has become an issue, but the overwhelming sentiment was one of optimism in getting these issues out to a broader audience.
Raising Your Tentpole proved to be another popular panel, apparently many aspiring to bypass the slow ascent to success and jump straight into developing and producing franchise faire. Panelists incl
uded Gale Anne Hurd, Bonnie Arnold and Kevin Feige, among others, as they discussed the ups and downs of creating content through the studio machine.
Perhaps more useful to the indie producer was the panel Plugged In: The Socially Networked Producer where Elias Plishner, Sony Senior VP of Digital Marketing who headed up the Social Network campaign, told the audience that it's never too early to start engaging fans of your project through social media channels to build "pre-awareness." Not surprisingly, the panel discussed how actors are cast based on their Twitter following as it is assumed that that will become part of the marketing package.
Meanwhile, in the conversation panel with Harvey Weinstein and Mark Gordon, the view on internet distribution and Video on Demand (VOD) was lukewarm. Both Weinstein and Gordon expressed that while it is the future, the current business model should continue to focus on the theatrical release.
A major announcement from the conference came from the CEO of Scenios, Mark Davis, who unveiled that their production management software will now be available entirely in "the cloud." This type of platform will allow production teams to collaborate from pre-production through production and then into post and will include a collection of apps that manages items like the script, budget, locations, shoot schedule, call sheets, dailies and rough cuts.
Gina Hall writes for publications such as Greening Hollywood, as a guest blogger, Culver City News, AskMissA.com and TheScoopLA. She graduated from the University of Southern California with a degree in Cinematic Arts and has worked in the entertainment industry on documentaries and features, as a development executive and as a writer. She works with environmental organization Global Green USA whose efforts are primarily focused on fighting global climate change through policies, advocacy and education.
Eco Consulting * Eco Media Green Blog Network * Greening Hollywood *
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What is best in life?
An iPhone 3G in your pocket, the wind in your hair, and 70+ markets to roam in?
To crush your enemies, see them driven before you, and to hear the lamentation of their handset users.
Thus Apple dropped the Steve Jobs Keynote BOOM! On the first round of iPhone Risk with news of over 70 regions signed on to carry the all new, all spectacular iPhone 3G. North America and much of Europe are currently set to get the next generation universe dent'er on July 11, with the rest "Coming Soon"/
Blanketing almost all the known continents (sorry Antarctica, see you come 4G!) and countries (with the huge gaping exception of China?), iPhone Risk, post WWDC edition, is now soundly under the "Epic Win" column, even as the scorecard strains under the map-bending load, which we include after the break.
Launched: Austria (T-Mobile), France (Orange), Germany (T-Mobile), Ireland (O2), UK (O2), USA (AT&T)
Announced: Africa (Orange), Argentina (America Movil), Australia (Vodafone / SingTel), Austria (Orange), Belgium (Orange), Brazil (America Movil), Canada (Rogers), Chile (America Movil), Columbia (America Movil), the Czech Republic (Vodafone), Denmark (TeliaSonera), Dominican Republic (America Movil/ Orange), Ecuador (America Movil), Egypt (Vodafone / Orange), El Salvador (America Movil), Estonia (TeliaSonera), Finland (TeliaSonera), Greece (Vodafone), Guatamala (America Movil), Honduras (America Movil), Hong Kong SAR (Hutchison) India (Vodafone / SingTel), Italy (Vodafone / Telecom Italia), Jamaica (America Movil), Japan (Softbank), Jordan (Orange), Latvia (TeliaSonera), Lithuania (TeliaSonera), Macao (Hutchison), Mexico (America Movil), New Zealand (Vodafone), Nicaragua (America Movil), Norway (TeliaSonera), Paraguay (America Movil), Peru (America Movil), Philippines (SingTel), Poland (Orange), Portugal (Vodafone / Orange), Puerto Rico (America Movil), Romania (Orange), Singapore (SingTel), Slovakia (Orange), Spain (Movistar), South Africa (Vodafone), Switzerland (Swisscom / Orange), Turkey (Vodafone), Uruguay (America Movil)
Rumored: Netherlands (?),
Note: Extent of America Movil and Orange Africa deployment not yet fully mapped.
Perplexing personal note: Apple Canada is directing "where to buy" queries to Rogers/Fido. Here's hoping that, come July 11, I can deal with Apple, and not the local GSM monopoly at least as far as acquisition goes...
What's happening in your non-US market?
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Satechi's new magnetic charging cable latches onto iPhone 12 like MagSafe
Satechi is showing that Apple isn't the only one that can make a magnetic charger.
Review: Razer's Hammerhead Pro earbuds are AirPods Pro for gamers
Razer is best known as a gaming brand, but it's been moving into more regular lifestyle products lately. The Hammerhead True Wireless Pro earbuds are the brand's answer to AirPods Pro, so how does it hold up?
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Dive deep into Hyrulian lore with these great books
If you or someone you know is obsessed with The Legend of Zelda and just can't get enough, the fun doesn't stop at the games. There are plenty of books to satisfy your need for all things Zelda from comic books to artwork.


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The Australian Chapter of BDSRA
The Batten Disease Association is an organisation dedicated to improving the well-being of patients and families suffering from Batten disease, a severe and progressive inherited neurological disorder that primarily affects children and young persons.? It is one of a group of about 50 disorders collectively known as lysosomal storage disorders.? Batten disease primarily affects brain function, leading to the loss of learned skills such as walking, talking and feeding, behavioral problems such... Read More
Batten disease (Neuronal Ceroid Lipofuscinoses) is an inherited disorder of the nervous system that usually manifests itself in childhood. Batten disease is named after the British paediatrician who first described it in 1903. It is one of a group of disorders called neuronal ceroid lipofuscinoses (or NCLs). ?Although Batten disease is the juvenile form of NCL, most doctors use the same term to describe all forms of NCL. Early symptoms of Batten disease (or NCL) usually appear in childhood when... Read More


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Export 17 results:
Filters: Author is Moreau, Adrien [Clear All Filters]
A leaky voltage sensor domain of cardiac sodium channels causes arrhythmias associated with dilated cardiomyopathy. Sci Rep. 2018;8(1):13804.
A New Cardiac Channelopathy: From Clinical Phenotypes to Molecular Mechanisms Associated With Na1.5 Gating Pores. Front Cardiovasc Med. 2018;5:139.
Biophysical, Molecular, and Pharmacological Characterization of Voltage-Dependent Sodium Channels From Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Can J Cardiol. 2017;33(2):269-278.
Induced pluripotent stem-cell-derived cardiomyocytes: cardiac applications, opportunities, and challenges. Can J Physiol Pharmacol. 2017;95(10):1108-1116.
Biophysical characterization of the honeybee DSC1 orthologue reveals a novel voltage-dependent Ca2+ channel subfamily: CaV4. J Gen Physiol. 2016;148(2):133-45.
Characterization of the honeybee AmNaV1 channel and tools to assess the toxicity of insecticides. Sci Rep. 2015;5:12475.
Gating pore currents, a new pathological mechanism underlying cardiac arrhythmias associated with dilated cardiomyopathy. Channels (Austin). 2015;9(3):139-44.
Gating pore currents are defects in common with two Nav1.5 mutations in patients with mixed arrhythmias and dilated cardiomyopathy. J Gen Physiol. 2015;145(2):93-106.
Mutations in the Voltage Sensors of Domains I and II of Nav1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents. Front Pharmacol. 2015;6:301.
[Omega pore, an alternative ion channel permeation pathway involved in the development of several channelopathies]. Med Sci (Paris). 2015;31(8-9):735-41.
Biophysics, pathophysiology, and pharmacology of ion channel gating pores. Front Pharmacol. 2014;5:53.
Molecular biology and biophysical properties of ion channel gating pores. Q Rev Biophys. 2014;47(4):364-88.
Nav 1.5 mutations linked to dilated cardiomyopathy phenotypes: Is the gating pore current the missing link? Channels (Austin). 2014;8(1):90-4.
Novel SCN5A mutations in two families with "Brugada-like" ST elevation in the inferior leads and conduction disturbances. J Interv Card Electrophysiol. 2013;37(2):131-40.
Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutation. Front Pharmacol. 2013;4:126.
Gating pore currents and the resting state of Nav1.4 voltage sensor domains. Proc Natl Acad Sci USA. 2012;109(47):19250-5.
Mexiletine differentially restores the trafficking defects caused by two brugada syndrome mutations. Front Pharmacol. 2012;3:62.


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A couple of my Twitter friends let me know that on Friday the 13th Jeopardy used Gluten-Free Foods as a category. Has gluten free made the big time finally by landing on America's Favorite Quiz Show? Based on the comments regarding the category I think not.
After doing a little research I learned that it was the last category chosen by the contestants and that the answers to the questions were brand specific. Most of the answers were companies whose product can be bought on any grocery store shelf, such as Yoplait Yogurt, Spam, V-8, and Coke Zero to name some.
It is truly disappointing that the researchers who work for Jeopardy didn't do a little more research into the exponentially expanding gluten-free products market. If they had they would have discovered that some companies don't use safe manufacturing practices, but still label their products Read More »


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Zynga Gets Rid of Some of Its Dogs
Jan 2, 2013 12:58 PM PT
Zynga has closed down 11 of its social games this week, including PetVille, Mafia Wars 2, Vampire Wars and Mafia Wars Shakedown. Some of the titles were completely shut down, while others were pulled from app stores or simply stopped accepting new players.
Zynga intends to reallocate resources to more successful titles while working to create new games. This wasn't a sudden end-of-game move, as the company said back in October that it would be shuttering some underperforming titles.
"Zynga is trying to retool to move away from just riding the casual game gravy train on Facebook," said P.J. McNealy, a consultant with Digital World Research. "Their focus continues to shift to more core gaming and prepping for the possibility of real-money online gambling games in the U.S."
Zynga did not respond to our request for further details.
End Game and New Beginning
Zynga appears to be entering the new year with a new streamlined vision and direction. The company had been criticized for overextending itself, especially in developing multiple Facebook-based titles as its profile rose with the social media giant.
In addition, Zynga launched numerous titles in advance of its IPO, but when its stock price fell -- much like Facebook's did -- it seemed that investors had lost confidence, and to some extent patience, with the direction the social game maker was taking.
"Zynga's game shutdowns should not have come as a surprise," said Billy Pidgeon, senior analyst at Analyst Inside Network.
"In October, prior to a disappointing Q3 earnings report, the company announced it was shutting down 13 older games as part of a cost-reduction plan, also including staff reductions and studio closures," he told the E-Commerce Times. "Typically resource and overhead cutbacks inspire investor confidence, but revenue gains are expected to follow."
Now that those underperforming and older games have been shut down, the company is refocusing -- and that doesn't mean rolling out a "PetVille 2" or "Mafia Wars 3," and hoping old and new players alike will start playing.
"There will be some savings in ending those games, but Zynga will have to make some payouts to long-time players," added Pidgeon.
"Freeing up some resources is a positive, as that staff can be reassigned to new projects, but Zynga is under considerable pressure to move to mobile and to gain more revenue, the company will need to increase their overall and paying audience size and their hits-to-misses ratio," he explained.
More Than 'Just a Game'
One concern is whether players who committed years to a game will abandon Zynga when their favorite pastime is snatched away. Even though their numbers are down, sending PetVille players' digital creatures to that proverbial farm, never to return, could cost Zynga some loyalty.
Zynga will still have more than 30 titles available across multiple platforms including Facebook, Zynga.com, iOS, Android and Myspace. It will work to appease those whose favorites were shut down by offering free bonus packages of virtual goods on its current flagship titles such as CastleVille and FarmVille 2.
A major unknown for Zynga is whether its move to social gambling is a bet that will pay off.
"Zynga has made additional investments in mid-core game development and in social gambling, and these may bring in more revenue in time -- but not in the short term," noted Pidgeon. "Zynga could continue to lose market share to competitors, as it takes significant time to develop new games."
Will gamers -- especially social gamers who have no shortage of offerings, as well as plenty of Angry Birds titles to play -- be patient?
"Turnaround and change doesn't take place overnight, especially for a public company," added McNealy. "Zynga has proven this repeatedly."


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Back pain that interferes with normal daily activities may require surgery for treatment. Laminectomy is a type of surgery in which a surgeon removes part or all of the vertebral bone (lamina). This helps relieve compression of the spinal cord or the nerve roots that may be caused by injury, herniated disk, spinal stenosis (narrowing of the canal), or tumors. A laminectomy is considered only after medical treatments have proven to be ineffective.
Low back pain can range from mild, dull, annoying pain, to persistent, severe, and disabling pain. Pain in the lower back can restrict your ability to move and function. Laminectomy may be done to relieve pressure on the spinal nerves, treat a disk problem, or remove a tumor from the spine.
One common reason for having a laminectomy is a herniated disk in the spine.
A disk may be displaced or damaged because of injury or wear and tear. When the disk presses on the spinal nerves, this causes pain, and sometimes numbness or weakness. The numbness or weakness will be felt in the body part where the nerve is involved, often the arms or legs. The most common symptom of a herniated disk is sciatica (generally, a sharp, shooting pain along the sciatic nerve, extending from the buttocks to the thigh and down the back of the leg).
If medical treatments are no longer effective, back surgery may be an option. Some medical treatments for back pain may include:
Laminectomy is usually done for back pain that continues after medical treatment, or when the back pain is accompanied by symptoms of nerve damage, such as numbness or weakness in the legs.
There may be other reasons for your healthcare provider to recommend a laminectomy.
As with any surgical procedure, complications can occur. Some possible complications may include:
Nerve or blood vessels in the area of surgery may be injured, resulting in weakness or numbness. The pain may not be relieved by the surgery or may become worse, although this is rare.
There may be other risks depending upon your specific medical condition. Be sure to discuss any concerns with your healthcare provider prior to the surgery.
A laminectomy usually requires a stay in a hospital. Procedures may vary depending on your condition and your doctor's practices.
A laminectomy may be done while you are asleep under general anesthesia, or while you are awake under spinal anesthesia. If spinal anesthesia is used, you will have no feeling from your waist down. Newer techniques are being developed that may allow a laminectomy to be done under local anesthesia on an outpatient basis. Your doctor will discuss this with you in advance.
Generally, a laminectomy follows this process:
After the surgery you will be taken to the recovery room for observation. Once your blood pressure, pulse, and breathing are stable and you are alert, you will be taken to your hospital room. Laminectomy usually requires a hospital stay of one or more days.
You will most likely begin getting out of bed and walking the evening of your surgery. Your pain will be controlled with medication so that you can participate in the exercise. You may be given an exercise plan to follow both in the hospital and after discharge.
Once you are at home, it is important to keep the surgical incision area clean and dry. Your healthcare provider will give you specific bathing instructions. The surgical staples or stitches are removed during a follow-up office visit.
Take a pain reliever for soreness as recommended by your healthcare provider. Aspirin or certain other pain medications may increase the chance of bleeding. Be sure to take only recommended medications.
Notify your healthcare provider to report any of the following:
You should not drive until your healthcare provider tells you to. You should avoid bending over to pick up objects or arching your back. Other activity restrictions may apply.
Your healthcare provider may give you additional or alternate instructions after the procedure, depending on your particular situation.
Before you agree to the test or the procedure make sure you know:
Vidant Health can connect you to health care professionals to help you understand your condition and guide you through the treatment process. Let's chat.


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Can my employer request me to work for nine hours from Mondays to Thursdays and four hours on Fridays without paying me overtime?
No. Any work in excess of the normal hours, that is maximum of eight hours, will earn overtime pay. Thus, the employer will be required to pay the worker overtime for the extra hour worked on Mondays to Thursdays.
NO, the Loan Programme is a National Programme created to assist Virgin Islander or Belonger owned businesses that require access to financial assistance.
Yes. This is an exception in some instances. However, where the person will be permanently employed, they must acquire a food handler's certificate from the Environmental Health Division.


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I was reminded by the blustery wet south-easterly tail wind on my cycle to work this morning that summer has yet to arrive to this part of the world. However, as an Archaeological Information Systems Manager for English Heritage based down in Fort Cumberland, Portsmouth, I'm mostly office based so the weather is only an issue when I venture out to get a cup of coffee.
It has finally become apparent to me that communication is one of my main focuses. I am always asked what period or location I specialise in, the truth is I don't take this approach to archaeology. My passion is for archaeology and archaeologists, how we communicate with each other and how we communicate with the public (who's support we depend to continue doing what we do).
So back to my day…
After arriving in my office and making a cup of coffee I turned my attention to finalising a paper I've been writing called 'Can you hack (the) communication?' I gave a presentation on this at CAA in Southampton (http://caaconference.org/) (it's a computers and archaeology conference) back in March. This paper looks at how we as archaeologists capture digital information in the field and particular my perspective on the experience of implementing a digital recording system for archaeological excavation called Intrasis to our teams. We've used the system now on our last few projects.
As main ringleader of social media at the fort, I started receiving my colleagues' posts for Day of Archaeology by mid-morning. That I know of two others are participating, one from our zooarchaeologists and another from @nicola_hembrey, our finds archaeologists.
Through out the day, like most days I'm keeping an eye on my Twitter feed for good content and information @hscorley. I also am keeping an eye on the @EHArchaeology twitter account which I am primary curator. This account has been active for about 3 years now and I'm amazed how popular it has become.
Looking at Twitter today, it is of course, abuzz with Day of Archaeology content. Particular praise is due to London Archaeological Archive & Research Centre (LAARC) for the LAARC Lottery. If only I had thought if it myself. You pick a number for a shelf, they then go and find what's on that shelf and blog about it. I like this for several reasons, not only is it interactive and raises awareness about their archive but it also means no one has to think to hard about what to write about, it's all there just waiting to written about.
As my day wraps up I'm going to prepare to face the elements again, the wind does not appear to have shifted and despite a bit of sunlight earlier it looks like it might rain.
Hugh Corley


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Gauge Your Salon's First Impression
"You never get a second chance to make a first impression."
It's a saying you've likely heard many times. But, think a moment about this concept and how it relates to the design or your salon or spa.
Each time a client walks through your doors, she forms an immediate opinion about your business. And, while that impression may later be shaped by the interaction the client has with the stylist and her experience in the chair, in those few moments that she walks in the door, she is forming an opinion about whether you are the kind of establishment that keeps up with current trends and is a luxurious place to de-stress or whether you are an outdated, second-rate facility.
Take a walk through your salon doors with a new set of eyes. What do you see?
Leslie McGwire, Allied, ASID (American Society of Interior Designers) has more than 29 years in business development, interior design, and sales and marketing services for the health, wellness, fitness, beauty, healthcare and hospitality environments and retail, salons, hotels, resorts and spa-based businesses. She is president of Leslie McGwire & Associates which specializes in the beauty and spa industry with hundreds of projects in the portfolio, including award-winning design. From concept to creations, McGwire offers premiere design services anywhere in the US or abroad. She also is an industry educator and a frequent speaker at trade shows. For more information, contact lesliemcgwire.com.
– See more at: http://www.salontoday.com/blogs/guest/Gauge-Your-Salons-First-Impression-239116641.html#sthash.oLQQ81Ty.dpuf.


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A healthy dividend yield of 2.1% and a long-term earnings growth projection of 12% make Limited Brands Inc. (LTD) a viable option for investors seeking growth and income.
Earnings estimates for this Zacks #2 Rank (Buy) specialty retailer of women's intimate and other apparels have advanced since its fiscal third-quarter report in November, which marked the ninth straight quarter with a positive surprise. The company also raised its outlook for the full year. LTD has been focused on cost containment, inventory management, merchandise initiatives and its rational store expansion strategy.
Limited Brands Beats, Ups Outlook
On November 14, Limited Brands posted fiscal third-quarter earnings of 26 cents per share, which surpassed the Zacks Consensus Estimate by 4%. Net sales of $2,050.2 million dropped 6% year over year but topped the Zacks Consensus Estimate of $2,045 million. Limited Brands delivered comparable-store sales growth of 5% during the quarter, compared with 9% in the prior year.
Sales grew 7% at Victoria's Secret Stores & Victoria's Secret Beauty, but fell 2% at Victoria's Secret Direct. Total sales at Victoria Secret and Bath & Body Works & The White Barn Candle Co. both jumped 5% and 7%, respectively. However, sales at La Senza tumbled 11%.
Gross profit climbed 6% to $835.6 million, whereas gross margin expanded 470 basis points to 40.8%. Operating income advanced 6% to $197.4 million, whereas operating margin rose 100 basis points to 9.6%.
Management projects earnings of $1.62 to $1.77 for the fourth quarter and between $2.78 and $2.93 per share for the fiscal year. Previously, the company had forecasted earnings of $2.73 to $2.88 per share for the year. Limited Brands expects comparable-store sales to increase between 2% and 4% during the fourth quarter and 5% in the fiscal year ending this month.
Earnings Estimates Climbing
The Zacks Consensus Estimate for the current fiscal year edged up 1% to $2.92 per share in the past 60 days on the back of upward revisions from 19 of 20 estimates. This implies a year-over-year increase of 12.2%. For next fiscal year, the Zacks Consensus Estimate is up 0.6% to $3.27 in the same time, as 15 of 20 estimates were revised higher. The current estimate implies year-over-year growth of 12.3%.
Dividend Strength
Limited Brands has been actively managing its cash flows and returning much of its free cash to shareholders via dividends, while maintaining a healthy balance sheet and credit ratios that are necessary for an investment-grade rating. The quarterly dividend was increased 25% to 25 cents per share in January 2012, and currently yields 2.1%.
The company also paid a special dividend of $3 per share on December 26. Over the years, the company has steadily increased its dividend payout. Limited Brands' commitment toward enhancing shareholder returns reflects its sound liquidity position and well defined future prospects.
Valuation Stretched, Yet Lucrative
Limited Brands currently trades at a forward P/E of 16.19x, reflecting a 13.5% premium to the peer group average of 14.27x. Again, its price-to-sales ratio of 1.34 is at a substantial premium to the peer group average of 0.91. Given the long-term earnings growth projection of 12%, the PEG ratio stands at 1.35, above the benchmark of 1 for a fairly priced stock. The return on assets (ROA) for the stock looks impressive. It has a trailing 12-month ROA of 12.5% compared with 10.5% for its peer group.
The stock price has now started to correlate with the increasing trend in estimates. Currently, the stock price is in the range of $45.00–$50.00, and the consensus estimates for fiscal 2012 and 2013 are steadily moving upward.
Limited Brands is a specialty retailer of women's intimate and other apparels, beauty and personal care products, home fragrance products and accessories. The company conducts its business primarily through two reportable segments – Victoria's Secret and Bath & Body Works. The Victoria's Secret segment sells merchandise under the brand names such as Victoria's Secret, Pink and La Senza. Limited Brands, which competes with Gap Inc. (GPS), has a market cap of $13.67 billion.
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