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Aurora TV Unit Melamine 170x40x50 Knotty Oak/Grey Wht/Blue.
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However, if you are not fully satisfied with your purchase within 7 days after delivery, please contact us to discuss your concerns.
We may, at our discretion and only if the goods are in saleable condition, either exchange your purchase or accept your purchase back, whereby a credit will be issued for use against future purchases. Freight and associated costs of all product exchanges or returns will be met by the customer.
Goods specially ordered in or custom made are non-returnable.
If the goods are faulty, we will meet our obligations under the Consumer Guarantees Act to provide a remedy.
The Consumer Guarantees Act sets the minimum standards for goods sold by Nido. If goods sold are deficient or faulty, the retailer has the obligation to repair, replace or refund.
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Nido understands that customers may change their mind; we have a 7-day Change-of-Mind Policy with proof of purchase.
The Change-of-Mind Policy covers the price of the product, excluding any freight or delivery costs incurred.
For a product to be returned under our Change-of-Mind policy, the product must be returned to us within 7 days from the original purchase date, in a resaleable condition, unless faulty or otherwise defective, with proof of purchase. Nido is not responsible for any costs associated with returning the product to us under the Change-of-Mind Policy.
Beyond our 7-day Change-of-Mind Policy we may accept returns up to 28 days from the original purchase date with proof of purchase, however a restocking fee will apply. A restocking fee will be charged and must be paid first before a full refund of the product price being released. The restocking fees for returns are either:
Nido may not accept returns where the product at all if damaged beyond recovery.
Should Nido need to arrange for transport to recover the products from the customer's premises, a further delivery charge will apply and must be paid at the time of the restocking fee being paid.
We can offer to exchange products for another one (i.e. a different size or colour etc) or another product of the same value without the need to charge a restocking fee within 28 days from the original purchase date. Proof of purchase is required to obtain an exchange. To be eligible for an exchange, products must be in a resaleable condition and where possible with packaging intact and all labels, manuals, etc., returned with the product.
Where a product is faulty or damaged due to a manufacturing fault we will, with proof of purchase, either:
Products can be returned in-store or couriered back to us. Nido is not responsible for any costs involved in returning products to us, unless the product, once assessed, is deemed to be faulty or damaged due to a manufacturing fault. Prior to couriering any products to us, please contact us for the relevant details. Nido is not responsible for any missing or lost parcels.
If the returned product is still under warranty, the repair will be at our expense. If the product is out of warranty period, then we can still have the product repaired, however the cost of the repair will be charged to the customer unless the product is found to have a manufacturer's fault.
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subset: commoncrawl


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Help women get access to information how they can safely do an abortion themselves. Scroll down, click on the sticker in your language, print and paste it everywhere: public bathrooms, cafes, restaurants, busses, trains, waiting rooms, and dressing rooms.
Paste sticker
Aborto con pastillas Sticker
Abortion with pills English
Aborto com comprimidos, sticker PT
misoprostol russian
vietnamese misoprostol
misoprostol sticker filipino
misoprostol sticker chinese
misoprostol spanish
Misoprostol sticker french
Arabic ijhad sticker
misoprostol sticker thai
Misoprostol Indonesia
misoprostol sticker urdu
Urdu 2
swahili sticker
Misoprostol sticker polish
farsi safe abortion sticker
sticker kurdish
Women on Waves only sends newsletters and press releases can send you our press releases to announce a campaign or…
Read more »
Living in a country where safe abortion is not available? Get abortion pills online. Women on Web helps women get access to a safe medical abortion and refers to a licensed doctor who can provide a medical abortion.
Women on Web website is censored in some countries. Here are all the ways you can bypass the blockage.
Read more »
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*هل تٌريدين الإجهاض الآمن (حتى الأسبوع اﻟ 12)؟
ضعي أربعة حبوب من الميسوبروستول (200 ميكروغرام) تحت لِسانك (لا تبلعيها…
Read more »


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Apple iPhone is one of the most talked about mobile devices today and it is in news again as rumours of iPhone 5S makes the round at a Chinese site.
If news from The Commercial Times is to be believed, we may hold the updated version of iPhone 5 as soon as the first quarter of 2013 (Q1 2013).
This news is surprising as Apple only recently launched the much anticipated iPhone 5 and one would think the company will wait to launch an update to this bestselling smartphone.
However, this Chinese site insists the world will have the iPhone 5S complete with features it could not include in the newly released version.
Apple has made no formal announcements to this end but the trial production of the new model is set to begin in December 2012.
Fighting for the top spot
It is believed that Apple intends to quickly introduce the next version to the world because it is facing tough competition from Samsung's Galaxy S3 and a few other players in the market.
The fight for the top spot is on; this is perhaps why iPhone 5S will go under the trial production next month. Initially, Apple will order the production of 50,000 and 100,000 units, according to The Commercial Times.
"Facing low yield rates in the production of iPhone 5, Apple has accelerated the certification processes for related parts and components for the iPhone 5S," the paper said.
iPhone 5S is not the only Apple device to hit the market next year as the tech giant is also rumoured to launch an updated version of iPad in 2013.
iPad is said to be updated as buyers are not pleased with the display resolution of the current version. Apple expects to boost its global sales and strengthen its position in the mobile devices market with these two rumoured upcoming launches.


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New zoning district gets nod
At their first full meeting, Cape Coral's new city council got a lot accomplished Monday, including setting up a new zoning district designed to bring large industrial and commercial businesses to the north Cape.
The new High Intensity Commercial Industrial District will provide for intense non-residential development north of Pine Island Road. All development north of that area must go through the PDP process.
No dwellings will be permitted, and the minimum development area is 10 acres, 30 percent of which must be kept as open space.
Perhaps the most action came during public comment, when several residents from the Lake Kennedy area came forward to voice their complaints over the lack of meetings between the neighborhood associations in the area and the kayak club over their lease and proposed training facility.
"Meetings were expected to be held, but not before the holiday. It's like the city hasn't offered anything but token meetings," said one resident. "My daughter asked to be part of the committee, but was told if she could not be at all the meetings, she can't be part of the committee."
The previous council tabled an ordinance during its last full meeting on Nov. 4 that would have allowed the kayak club to lease a house on Lake Kennedy for $10 per year and turn the area around there into a year-round training facility.
Neighbors balked at the idea, saying those who bought property there to be around the lake would be infringed upon, especially those who own motorboats.
Parks and Recs Director Steve Pohlman suggested the legislation be pushed back to Dec. 16, the last meeting before winter hiatus, to give both sides a chance to meet.
Councilmember Rick Williams said he wanted to "drive a nail in it" by then, since it would give the kayak club time to decide its next move if the facility and lease are rejected.
Councilmember Lenny Nesta still showed strong support for the proposed training facility.
"This will put the city on the map and bring children in. I don't think residents would have a problem with kids paddling along the seawall," Nesta said.
The city also approved an amendment to the city's operating budget that increases expenditures and revenues by $88.92 million, the vast amount coming from the Southwest 6 & 7 utilities expansion project.
There also was a presentation concerning the annual investment report for the city, which showed the city earned more than $1.5 million in interest earnings for the fiscal year, with its investments surpassing benchmark performance, according to Steve Alexander of PFM Asset Management.
However, Councilmember Jim Burch was concerned by the city's use of low risk securities for its investments, with their rather low return as opposed to the stock market, which has seen a fast steady climb over the last four-plus years.
"The stock market had a great year and we rely entirely on bonds and the bond market isn't going to get better soon," Burch said.
The city also passed a resolution to approve purchases of budgeted equipment and vehicle assets within the city's funds, and a resolution to adopt financial management policies for the city relating to the management of its operating budget, debt management, financial planning and economic resources.


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URGENT: Two Opportunities to Protect Charitable Giving Incentives
July 22, 2013
Among the wide array of urgent national policy issues in motion, orchestras have stepped up in record numbers to ask Congress to protect charitable giving incentives. Our work isn't done. As Congress continues to consider tax reform proposals, the charitable deduction and other giving incentives hang in the balance. Here are two ways your orchestra can stay engaged in this critical policy discussion:
Take a Seat at the Nonprofit Policy Table: Partnering with the broader nonprofit community is essential as we communicate the importance of the charitable deduction. The League is an active member of Independent Sector and the Charitable Giving Coalition, participating as a lead advocate side-by-side with the broader array of nonprofit organizations that serve communities nationwide. A national sign-on letter to the Senate is currently circulating, and your orchestra is invited to join other nonprofits going on record in support of charitable giving incentives. You can add your orchestra's name to the Independent Sector letter - just sign on by Wednesday, July 24.
Develop Your Relationship with Members of Congress: The ongoing discussion of tax reform presents a key opportunity to better inform your elected officials of the public value of your organization, and to explain that your orchestra is part of the fabric of the broader nonprofit sector that serves your community. Throughout the month of August, members of Congress will be returning to their districts and states. Consider using this time to meet with policymakers, acquaint them with the work your orchestra will be doing in the coming season, and invite them to experience your orchestra in action. Please contact our DC office to share information about your relationship with elected officials – we put that information to work on the Hill on the full range of policy issues impacting orchestras nationwide.


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The Inside Network Job Board: Sunrun, Booking.com, Changyou.com, and more
This sponsored post includes companies who have paid to have their job listings advertised on our job board
The Inside Network Job Board, powered by Mediabistro, is dedicated to providing you with the best social media job opportunities across social and mobile application platforms. Here are this week's highlights from the Inside Network Job Board, including positions at: Machine Zone, Appboy, Brightroll and more. Post a job on Inside Network's Job Board.
- Senior Manager of Ad Operations
- Campaign Manager (Detroit)
- Account Manager (CHI)
- Campaign Manager – Media Department, Santa Monica
- Business Development Manager (Browser/Mobile Game)
- Game Translator – Portuguese/Production Assistant


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I forgot to tell my insurer about a ticket
Question: Will an insurer care that I forgot to list a speeding ticket I got last year? It slipped my mind while shopping for a new insurance policy. Is it really that important that the insurance company knows about all of my violations?
Answer: Yes. Your rates were based on the insurance company's calculation of the risk you posed. More tickets equal more risk of claim.
Usually an insurance company will find out about a ticket even if you accidentally (or purposely) leave one out. At that point, if the omission is a minor violation, the company will recalculate your premium based on the new information. But the new rate isn't a punishment for lying or forgetting, only a recognition that you're not quite the risk you said you were.
To give you an accurate quote , you need to supply an auto insurance provider with accurate information. The quote you get is based on the personal information you provide. If you decide to act on the quote and buy a policy, the insurer then verifies the rating factor data you've given by requesting copies of certain reports, such as your credit history (if state laws allow), claims history ( C.L.U.E. report ), and motor vehicle record (MVR).
When something shows up on a report that you didn't inform the insurance company about, the insurer will re-evaluate if you're an acceptable risk. You may still be offered a policy, but your rates could change from what you were originally quoted. One minor ticket may not change rates much, if at all, but if it's a major offense expect your rates to jump significantly or the offer to disappear altogether.
If you already purchased a policy, then when the insurer finds the "forgotten" information you may be notified that your premiums were modified due to this new data and that to keep your policy in effect you will need to pay an additional premium amount.
If you don't pay the extra cost, the policy will cancel out. Or you may just be informed by the insurer that it's canceling your policy because it now perceives you to be a high-risk driver that they don't want to insure.
State laws on cancellation once a policy is started vary, but one typically allowable reason is misinformation on the application. Intentional misrepresentation can be seen as insurance fraud.
If your rates go up, or your policy is canceled after your insurer finds the missed speeding conviction, then shop around to get the best car insurance rates possible -- and this time make certain to provide insurers complete information. (See "12 ways to double-check your savings.")
Another insurer might not penalize you for an additional minor violation. The rules are very different at each company.
The views and opinions expressed herein are the views and opinions of the author and do not necessarily reflect those of Nasdaq, Inc.


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text:
As for the McCarthy situation it was resolved eventually .
after much hounding George deleted the inappropriate post .
I was at the time in personal contact with him and trying to get him to add his thoughts to a thread on HAPV .
he thought it better to stay out of it when it degraded by the time he had a chance to look at it .
It was a moment of personal embaressment .
But was just a case of human judgement/error and I prefer it be left there , we dont want to cause any more potential embarresment/offence to anyone .


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RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or Cannot Be Removed By Surgery
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01071564
Recruitment Status : Terminated
First Posted : February 19, 2010
Last Update Posted : April 15, 2015
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Estrogen Receptor Negative HER2/Neu Negative Progesterone Receptor Negative Recurrent Breast Carcinoma Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Triple-Negative Breast Carcinoma
|Drug: Gamma-Secretase Inhibitor RO4929097 Other: Laboratory Biomarker Analysis Other: Pharmacogenomic Study Other: Pharmacological Study Drug: Vismodegib
|Phase 1
I. To determine the safety and tolerability of continuous daily administration of 150 mg/day of GDC0449 (vismodegib) in combination with escalating doses of RO4929097 (gamma-secretase/Notch signalling pathway inhibitor RO4929097) administered on a repeated schedule of days 1-3, 8-10 every 21 days (for a total of 6 days of RO4929097 administration per 21 day cycle) in patients with advanced breast cancer.
II. To determine the dose limiting toxicity (DLT) and identify the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) for this administration schedule.
I. To determine the pharmacokinetics (PK) and pharmacogenetics (PG) of GDC0449 and RO4929097, each alone and in combination.
II. To attempt to evaluate select pharmacodynamic (PD) stem cell differentiation biomarkers in the hedgehog and notch signaling pathways (e.g. GLI family zinc finger [Gli]1/2/3, patched [Ptch] 1/2, hairy and enhancer of split 1, [Drosophila] [Hes1], huntingtin interacting protein 1 [Hip1], hairy/enhancer-of-split related with YRPW motif 1 [Hey1], Notch4, Jagged1, numb homolog [Drosophila] [numb], BMI1 polycomb ring finger oncogene [Bmi-1], cluster of differentiation [CD]44/CD24, aldehyde dehydrogenase [ALDH] proto-oncogene tyrosine-protein kinase [Src] family kinases) and the percentage of breast cancer stem cell (BCSC) in serial breast tumor biopsies before and after GDC0449 or RO4929097 alone and after 1 cycle of treatment with the combination of GDC0449 and RO4929097.
III. To determine tumor response in patients with measurable disease as assessed by the Response Evaluation Criteria in Solid Tumors (RECIST).
IV. To perform molecular profiling of the tumor cell and BCSC populations before and after GDC0449 or RO4929097 alone and after 1 cycle of treatment with the combination of GDC0449 and RO4929097 at the MTD.
OUTLINE: This is a dose-escalation study of gamma-secretase/Notch signalling pathway inhibitor RO4929097.
Patients receive gamma-secretase/Notch signalling pathway inhibitor RO4929097 orally (PO) on day 1 or days -2, -1, and 1 of course 1 and days 1-3 and 8-10 of course 2 and all subsequent courses. Patients also receive vismodegib PO once daily (QD) beginning day 8 of course 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up for 30 days.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|13 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase I Study of the Hedgehog Smoothened Antagonist GDC-0449 (NSC # 747691) Plus Pan-Notch Inhibitor RO4929097 (NSC # 749225) Administered in Patients With Advanced Breast Cancer
|Study Start Date :
|November 2009
|Actual Primary Completion Date :
|June 2014
|Actual Study Completion Date :
|June 2014
Experimental: Treatment (RO4929097 and vismodegib)
Patients receive gamma-secretase/Notch signalling pathway inhibitor RO4929097 PO on day 1 or days -2, -1, and 1 of course 1 and days 1-3 and 8-10 of course 2 and all subsequent courses. Patients also receive vismodegib PO QD beginning day 8 of course 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: Gamma-Secretase Inhibitor RO4929097
Given PO
Other Name: RO4929097
Other: Laboratory Biomarker Analysis
Correlative studies
Other: Pharmacogenomic Study
Correlative studies
Other Name: PHARMACOGENOMIC
Other: Pharmacological Study
Correlative studies
Drug: Vismodegib
Given PO
Other Names:
- MTD and/or RP2D of gamma-secretase/Notch signalling pathway inhibitor RO4929097, determined according to incidence of DLT, graded using the NCI CTCAE [ Time Frame: 6 weeks ]
- Occurrence of adverse events and the associated National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) grade [ Time Frame: Up to 30 days after completion of study treatment ]
- Occurrence of DLTs and the associated NCI CTCAE grade [ Time Frame: 6 weeks ]
- Change in gene expression levels [ Time Frame: Baseline to up to 30 days ]Will be summarized with descriptive statistics appropriate to such distributions.
- Change in percentage of select BCSC biomarkers in the Hh and Notch signaling pathways [ Time Frame: Baseline to 2 weeks of intervention ]Will be summarized with standard descriptive statistics (N, median, mean, standard deviation, minimum, maximum, and the 90% confidence interval for the mean).
- Max concentration (Cmax), time to Cmax (tmax), terminal half-life (t1/2), area under curve 0-infinity (AUC0-inf), AUC 0-next dose (AUCtlast), accumulation index (AI), Cmax steady state (Css, max), and min concentration steady state (Css, min) [ Time Frame: Course 1 days 1-3 or days -2, -1, and 1; course 1 days 17 and 21; and course 2 days 1, 7, 10, and 11 ]Single and multiple-dose PK parameters summarized with standard descriptive statistics (N, median, mean, standard deviation, minimum, maximum, and the 90% confidence interval for the mean).
- Measurement of tumor response using RECIST criteria before and after treatment [ Time Frame: Up to 30 days after completion of study treatment ]Will be described by point estimates and exact 90% confidence intervals for proportions using Wilson's method.
- Pharmacogenetics (PG) parameters, including, but not limited to, metabolizing enzymes (e.g., CYP3A5, 2C9, and UGT1A1) and transporters (e.g., ABCG2 and ABCB1) [ Time Frame: Baseline ]Summarized with standard descriptive statistics (N, median, mean, standard deviation, minimum, maximum, and the 90% confidence interval for the mean).
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients must be women with histologically or cytologically confirmed locally advanced breast cancer that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective
- Patients must be human epidermal growth factor receptor 2 (Her-2) non-expressing (if immunohistochemistry [IHC] 0 or 1+; fluorescent in situ [FISH] ratio less than 2; if IHC 2+, FISH ratio must be less than 2.0); once the MTD has been determined, the expansion phase will be limited to patients with estrogen receptor (ER), progesterone receptor (PR), and HER2 negative (i.e. "triple negative") disease; Her-2 will be assessed as above; ER and PR are considered negative if immunoperoxidase staining of tumor cell nuclei is < 5%
- Patients must have measurable disease per RECIST guidelines or evaluable (non-measurable) disease
- Patients MUST have tumor accessible and suitable for serial biopsy with 4-6 passes of a 16 or 18 gauge needle
- Patients must have Eastern Cooperative Oncology Group (ECOG) performance status =< 2 (Karnofsky >= 60%)
Prior therapy:
- Patients must have failed at least 1 prior systemic therapy for metastatic or locally advanced breast cancer
- IMPORTANT: Patients with chronic grade 1 or 2 toxicity may be eligible at the discretion of the Principal Investigator (e.g. grade 2 chemo-induced neuropathy); note that patients with ongoing alopecia of any grade will be eligible
- Chemotherapy: prior chemotherapy is allowed; patients must not have received chemotherapy for 3 weeks prior to the initiation of study treatment and must have full recovery from any acute effects of any prior chemotherapy; patients must not have had nitrosoureas or mitomycin C for 6 weeks prior to the initiation of study treatment
- Radiation: prior radiation therapy is allowed; patients must not have received minimal radiation therapy (=< 5% of their total marrow volume) within 3 weeks prior to the initiation of study treatment; otherwise, patients must not have received radiation therapy (> 5% of their total marrow volume) within 4 weeks prior to the initiation of study treatment; patients who have received prior radiation to 50% or more of their total marrow volume will be excluded
- Other therapies: prior experimental (non-Food and Drug Administration [FDA] approved) therapies and immunotherapies are allowed; patients must not have received these therapies for 30 days or five half- lives of the drug prior to the initiation of study treatment and must have full recovery from any acute effects of these therapies; patients who have prior treatment with either a gamma-secretase or hedgehog inhibitor will be excluded from participating in this study
- Patients must not have received allogeneic stem cell transplant
- Patients must not have co-morbid condition(s) that, at the opinion of the investigator, prevent safe treatment
- Patients must not have active infection or fever > 38.5 degree Celsius (C)
- Patients must not be human immunodeficiency virus (HIV)+, hepatitis B+ or hepatitis C+ (active or previous treatment)
- All patients must provide archival tissue block or paraffin sample from archival tissue block (approximately 10 sections) for use in pharmacodynamic and pharmacogenomics correlative studies
- Patients must agree to undergo a total of three serial biopsies for research purposes
- Patients with brain metastases will be eligible if condition is treated and stable for >= 1 month
- Patients must have a life expectancy of greater than 12 weeks
- Hemoglobin >= 9 g/dL
- Absolute neutrophil count (ANC) >= 1,500/mcL
- Platelets (PLT) >= 100,000/mcL
- Aspartate aminotransferase (AST), alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN); if liver metastases are present, =< 5 x ULN
- Alkaline phosphatase =< 2.0 x ULN; if bone or liver metastases are present, =< 5 x ULN
- Bilirubin =< 1.5 x ULN
- Creatinine =< 1.5 x ULN OR calculated or measured creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine above institutional normal
Women of childbearing potential must use two forms of contraception (i.e., barrier contraception and one other method of contraception) at least 4 weeks prior to study entry, for the duration of study participation, and for at least 12 months post-treatment; should a woman become pregnant or suspect she is pregnant while she or her partner are participating in this study and for 12 months after study participation, the patient should inform the treating physician immediately
- Pregnancy testing: women of childbearing potential are required to have a negative serum pregnancy test (with a sensitivity of at least 25 mIU/mL) within 10-14 days and within 24 hours prior to the first dose of RO4929097 or GDC-0449 (serum or urine); a pregnancy test (serum or urine) will be administered every cycle if their menstrual cycles are regular or every 2 weeks if their cycles are irregular while on study within the 24-hour period prior to the administration of study drug; a positive urine test must be confirmed by a serum pregnancy test; prior to dispensing study drug, the investigator must confirm and document the patient's use of two contraceptive methods, dates of negative pregnancy test, and confirm the patient's understanding of the teratogenic potential of RO4929097 and GDC-0449
Female patients of childbearing potential are defined as follows:
- Patients with regular menses
- Patients, after menarche with amenorrhea, irregular cycles, or using a contraceptive method that precludes withdrawal bleeding
- Women who have had tubal ligation
Female patients may be considered to NOT be of childbearing potential for the following reasons:
- The patient has undergone total abdominal hysterectomy with bilateral salpingo-oophorectomy or bilateral oophorectomy
- The patient is medically confirmed to be menopausal (no menstrual period) for 24 consecutive months
- Pre-pubertal females; the parent or guardian of young female patients who have not yet started menstruation should verify that menstruation has not begun; if a young female patient reaches menarche during the study, then she is to be considered as a woman of childbearing potential from that time forward
- Patient must have the ability to understand and the willingness to sign a written informed consent document
- Patients must have a corrected QT (QTc) interval of =< 450 msec in males and a QTc =< 470 msec in females as measured by electrocardiogram (ECG) using Bazett's formula
Exclusion Criteria:
- Patients who have had chemotherapy or radiotherapy within 3 weeks (4 weeks for those who received radiation therapy of > 5% of their total marrow volume; 6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from toxicities related to prior therapy are not eligible to participate in this study; patients who have been administered GDC-0449 or RO4929097 as part of a single or limited dosing study, such as a phase 0 study, should not necessarily be excluded from participating in this study solely because of receiving prior GDC-0449 or RO4929097
- Patients may not have received any other investigational agents within the preceding 30 days or five half- lives of the drug and must have full recovery from any acute effects of these investigational therapies
- Patients must not have received prior treatment with either a gamma-secretase or hedgehog inhibitor
- Patients with a requirement for antiarrhythmics or other medications known to prolong QTc
- Patients must not receive any other anti-cancer therapy (cytotoxic, biologic, radiation, or hormonal other than for replacement) while on this study except for medications that are prescribed for supportive care but may potentially have an anti-cancer effect (i.e. megestrol acetate, bisphosphonates); these medications must have been started 1 month prior to enrollment on this study
- Patients with a prior history of seizures
- Patients with known active brain metastases will be excluded from this clinical trial; patients with prior treated brain metastases (treated and stable for >= 1 month) are allowed, providing that they were not accompanied by seizures and that a baseline brain magnetic resonance imaging (MRI) scan prior to study entry demonstrates no current evidence of progressive brain metastases
- Any patient requiring chronic maintenance of white blood cell counts or granulocyte counts through the use of growth factor support (e.g. Neulasta, Neupogen)
- HIV-positive patients on combination antiretroviral therapy are ineligible
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with GDC-0449 or RO4929097
- Patients with malabsorption syndrome or other condition that would interfere with intestinal absorption; patients must be able to swallow tablets
- Patients with clinically active liver disease, including active viral or other hepatitis or cirrhosis, are ineligible
- Patients with uncontrolled hypocalcemia, hypomagnesemia, hyponatremia, hypophosphatemia or hypokalemia defined as less than the lower limit of normal for the institution, despite adequate electrolyte supplementation are excluded from this study
GDC is a cytochrome P450 2C9 (CYP2C9) inhibitor; CYP2C9 is an enzyme that metabolizes warfarin sodium (Coumadin) into an inactive metabolite; patients who are on warfarin anticoagulation are allowed to participate as long as they fit the following 4 criteria:
- They are therapeutic on a stable warfarin dose
- Their international normalized ratio (INR) target range is no greater than 3
- They are monitored with weekly INR testing
- They have no active bleeding or pathological condition that carries high risk of bleeding.
- Other anticoagulants, including enoxaparin (Lovenox) and fondaparinux (Arixtra) are also permitted
- Caution should be exercised when dosing RO4929097 and GDC-0449 concurrently with CYP2C8, CYP2C9, CYP2C19, and CYP3A4 substrates; furthermore, patients who are taking concurrent medications that are strong inducers/inhibitors or substrates of CYP2C8, CYP2C9, CYP2C19, and CYP3A4 should be switched to alternative medications to minimize any potential risk; investigators will make every effort to switch to another agent and assess the eligibility of the patient to participate in this study
- Baseline QTc > 450 msec in males and QTc > 470 msec in females by ECG using Bazett's formula
- Patients without accessible tumor or who refuse serial biopsies
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01071564
|United States, Maryland
|Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center
|Baltimore, Maryland, United States, 21287
|United States, Michigan
|University of Michigan University Hospital
|Ann Arbor, Michigan, United States, 48109
|Barbara Ann Karmanos Cancer Institute
|Detroit, Michigan, United States, 48201
|Principal Investigator:
|Patricia LoRusso
|Barbara Ann Karmanos Cancer Institute
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
NCI-2012-02064 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
2009-099 ( Other Identifier: Barbara Ann Karmanos Cancer Institute )
8420 ( Other Identifier: CTEP )
P30CA022453 ( U.S. NIH Grant/Contract )
U01CA062487 ( U.S. NIH Grant/Contract )
U01CA070095 ( U.S. NIH Grant/Contract )
|First Posted:
|February 19, 2010 Key Record Dates
|Last Update Posted:
|April 15, 2015
|Last Verified:
|April 2014
Breast Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms by Site
Breast Diseases
Skin Diseases


text: Chaetomium globosum Kunze : Fries (ATCC® 6205D-2™) Strain Designations: genomic DNA from QM 459 (ATCC 6205) / Product Format: dried Approximately 2 µg in 1X TE bufferOD260/OD280: 1.7 to 2.1 General Information Characteristics History Documentation Print Email Share Share this product Facebook Twitter Google+ Permits and Restrictions View Permits Deposited As Chaetomium globosum Kunze : Fries, teleomorph Strain Designations genomic DNA from QM 459 (ATCC 6205) Biosafety Level 1 Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. Product Format dried Approximately 2 µg in 1X TE bufferOD260/OD280: 1.7 to 2.1 Type Strain no Preceptrol® no Genome Sequenced Strain Yes Comments This preparation of high molecular weight DNA is appropriate for use in the polymerase chain reaction (PCR)* process and other molecular biology applications.*The PCR process is covered by patents owned by Hoffman-La Roche Inc. Use of the PCR process requires a license.Genomic DNA from Genome sequencing strain (Broad Institute, USA). Name of Depositor ATCC Special Collection DNA Cross References Nucleotide (GenBank) : EF524036 Chaetomium globosum strain ATCC 6205 internal transcribed spacer 1, partial sequence; 5.8S ribosomal RNA gene, complete sequence; and internal transcribed spacer 2, partial sequence. Nucleotide (GenBank) : AAFU01000000 Chaetomium globosum CBS 148.51, whole genome shotgun sequencing project. Permits These permits may be required for shipping this product: Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment. Basic Documentation Product Sheet Certificate of Analysis SDS


text:
History of Alamo Rent A Car
|Alamo Rent A Car opens four locations in Florida, pioneering the concept of Unlimited Free Mileage. Immediately carving its niche in the leisure car rental industry, Alamo focuses its mission on providing a fun, low-cost, high-value rental experience to family and leisure travelers. The brand quickly becomes one of the country's largest vacation rental providers and the largest provider to international travelers visiting North America.
|To facilitate the increase in leisure travelers, Alamo constructs its first state-of-the-art rental plaza in Tampa, Fla. Rental plazas serve hundreds of customers per hour in a modern, ultra-spacious environment. More plazas follow in other major leisure destinations including Orlando, Fla., home of the world's largest rental facility.
|Alamo introduces a new customized rental agreement the size of an airline ticket, and Instant Alamo Rent A Car, a program that stores a traveler's individual rental information for instant reference.
|Alamo revolutionizes collision damage waivers by introducing the first-ever price and coverage option for all renters. Alamo creates three new consumer-driven optional collision damage waiver products in Florida, named Waiver Savers®, which provide customers with three choices of price and coverage options tailored to their needs.
|Alamo launches the industry's first real-time Internet booking engine. Customers can visit Alamo.com to find locations, view rates and select their vehicle. Soon, Alamo.com expands to include a membership-services section and travel tools to find the weather, driving directions and fun activities for children to enjoy on their road trip.
|Alamo launches E-Process 2000, a group of technologically enhanced initiatives for tour operators, including electronic reservation links on the company's website, voucher-less rental processing and electronic billing.
|Alamo announces a partnership with Walt Disney World Resort and Disneyland Resort, making it the official rent a car company of the most frequented tourist attractions in North America.
|Alamo launches the industry's first and only online check-in system.
|Alamo is acquired by the Taylor Family of St. Louis, which today also owns and operates Enterprise Holdings. Alamo earns Budget Travel magazine's "Extra Mile Award" for its self-serve kiosks.
|Alamo launches a partnership with Japan Airlines (JAL) which allows members of JAL's frequent flyer program to earn miles when renting from any participating Alamo location in the U.S. and Canada.
|A new Alamo branch in downtown Waikiki opens, adding to existing Alamo locations at the Honolulu International Airport, the Disney Aulani Resort & Spa and Waikiki Discovery Bay.
|Alamo expands its Latin American – Caribbean footprint, entering Uruguay.
|Alamo's commitment to the leisure travel market has fostered longstanding partnerships with the airline industry, travel destinations, travel agents and tour operators around the world. Alamo's operations have since expanded throughout the United States, Canada, Mexico, Latin America and Asia.


text:
Sinaloa state in Mexico on the Bay of California is famous for seafood and our customers come many miles to enjoy these dishes at El Sinaloense here in San Mateo. Ejoy a real treat for lunch and dinner and with our catering. We also can help with parties! Explore our menu
1622 Palm Avenu
San Mateo, CA 94402
(650) 345-1180
Open 7 Days a Week, 11am-9pm


text:
LOS ANGELES - NASA is headed to Mars - again.
The space agency said Tuesday it plans to launch another mega-rover to Mars in 2020 that will be modeled after the wildly popular Curiosity. To keep costs down, engineers will borrow Curiosity's blueprints, build from spare parts where possible and use proven technology including the novel landing system that delivered the car-size rover inside an ancient crater in August.
The announcement comes as NASA reboots its Mars exploration program during tough fiscal times.
'If we act now, we can build one at the lowest possible price,' NASA sciences chief John Grunsfeld said in an interview.
Like Curiosity, the mission will be managed by the NASA Jet Propulsion Laboratory, but many other details still need to be worked out including where the rover will land and what instruments it will carry to the surface.
While the science goals are still fuzzy, NASA said the rover at the very least should kickstart a campaign to return Martian soil and rocks to Earth - a goal trumpeted by many scientists. The current rover doesn't have that capability.
Despite Curiosity's successful landing, the road to the launch pad was bumpy. At $2.5 billion, the project ran over schedule and over budget.
Jim Green, director of NASA's planetary science division, said the engineering hurdles have been fixed and he expected the new rover to cost less. One independent estimate put the mission at $1.5 billion, though NASA is working on its own cost estimate.
The red planet will see a flurry activity over the next several years. Next year, NASA plans to launch an orbiter to study the atmosphere followed by a relatively low-cost robotic lander in 2016.


text:
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Privacy Policy
Thank you for visiting a Cequent website. The following is a description of how we collect, store, and use the personal information you provide us through any of the websites operated by Cequent.
We encourage you to read this Privacy Policy before you submit any personal information on this website. For a complete description of our online privacy practices, please review the following details.
What does this Privacy Policy apply to?
Our Website and Information Collected Online
The privacy practices set forth in this Privacy Policy pertain only to the on-line collection of information through the Cequent Websites, but do not apply to information that may be collected by Cequent off-line.
Websites Not Covered by this Privacy Policy
This Privacy Policy does not apply to websites maintained by other companies or organizations to which we link, including websites that are operated by our parent or affiliate companies or that are not otherwise a part of the Cequent family of websites (collectively, "third party sites").
We encourage you to read the privacy policy of the third party sites to which you link before you submit any personal information to that site. We are not responsible, and disclaim any liability for the independent practices or content of any third party site.
Special Note to Non-U.S. Visitors
This Privacy Policy is intended to meet the laws and requirements of the United States, which may not necessarily be consistent with the laws and regulations of your home country. Any information that you provide to Cequent will be treated in accordance with this Privacy Policy.
Your Acceptance / Changes to this Privacy Policy
By using the Cequent Website, you are accepting the practices described in this Privacy Policy. If you do not agree to this Privacy Policy, please do not use this Website. We reserve the right to make changes to this Privacy Policy. Any changes will be posted in this Privacy Policy and material changes will generally apply only to activities and information collected on a going forward basis. We encourage you to review this Privacy Policy whenever you come back to this Site to make sure you are aware of any changes and how your information may be used. Your continued use of this Website signifies your acceptance of these changes.
What types of information do we collect?
To simply browse our Website, we do not ask you to provide any information. However, if you wish to participate in some of the features and services, we may ask you to provide certain personal and/or demographic information. Personal information (as used in this Privacy Policy) refers to any information that can be used to personally identify you or contact you online or offline. This may include, for example, your name, postal address, e-mail address, phone number ("personally identifiable information") as well as other non-personally identifiable information or demographic information such as your date of birth, age, gender, habits or preferences when such information is tied to your personally identifiable information (collectively, "personal information").
Personal information is only collected with your knowledge (i.e., if you voluntarily provide it to us through one of the many online forms available on the Cequent Website) and will usually take the form of:
Registration or sign-up
Sign up for a newsletter that is specific to an event, product, or website and that is not included under general website registration;
Sweepstakes, contests, or other promotions;
Surveys and polls;
Message boards and other interactive activities;
Purchasing a Cequent product through our online shopping system;
E-cards, tell-a-friend, or other one-time use features;
Feedback, questions, or comments through one of our Contact or "Ask the Expert" forms;
Information submitted in a business capacity (e.g., resumes, media requests, etc.);
Any other request that requires the submission of personal information (e.g., Consumer Panel, Product Request, "Where to Buy," etc.)
Note: depending on the Cequent site that you are visiting, some or many of the activities listed above may not be available.
The types and amount of information collected for the features listed above will vary depending on the activity. The requested personal information may include: first and last name, email address, home address (including city and state), telephone number (work or home), and (for those purchasing products online) credit card information. For some activities, you may be asked to create a username and/or password and/or to provide additional, demographic information, including: (i) your age or date of birth, (ii) gender, (iii) frequency of use, purchase, and consumption of certain Cequent products and/or other similar products, (iv) facts about your business, and/or, (v) other information relevant to the Cequent product you've purchased or the specific Site which you are visiting.
If demographic information is collected for an activity that also requires personal information, we may combine the demographic information with your personal information. Combining data allows us to customize the notices we send you and the content we provide you according to your interests and preferences
How do we use the information we collect?
Generally, all information collected is used for the purpose for which the information was collected or as otherwise identified at the point of collection or in this Privacy Policy. For example, if you sign up or register on a Cequent Website ("general website registration"), the information you provide is used to offer you the benefits and privileges that typically come along with registration. This may include access to and use of exclusive or personalized content or activities on the Cequent Websites (e.g., message boards, upload features, personalized recipe boxes, etc.), participation in special events and promotions (contests, sweepstakes, coupons, etc.), and the ability to receive the communications or marketing material you select at the time of registration or that automatically come with your registration. Similarly, if you contact us via an online contact form or through one of our Ask the Expert features, your information is used to respond to your inquiry or comment, and in some instances, post the answers to your question in anonymous form on the relevant Website. And, of course, any credit card information you provide us is used to fulfill and process your online purchases.
When registering or providing information on our Sites, you may also be given the option (through a check box or otherwise) to have your information used for an activity or service different from the primary activity or service that you are requesting. For example, if you are signing up for a contest or other promotion, you may also be able to sign up for newsletters or alerts from the Site hosting the promotion or from other Cequent Sites or products. If you choose to receive these additional services, Cequent will use your information to provide them to you.
Newsletters and Email
If you provide us your email address and/or mailing address (whether as part of our general website registration or for a specific newsletter or communication), the contact information you provide will be used to send you the specific newsletter, communication, or literature requested. In addition, you may receive communications introducing you to other Cequent brands or Websites. These materials may come in the form of regular mail or email, depending on the Site you register on and the information you provide during registration.
We may also use your email address to send you transactional or administrative communications (e.g., confirmation email when you purchase a product online or when you sign up for, or unsubscribe from, a specific registration or activity), as well as certain service-related announcements (e.g., notices about updates to our Privacy Policy, discontinued features or programs on our Websites, changes to our online services or technical support policies, or other related changes). Collectively, these types of communications are referred to in this Privacy Policy as "Administrative Communications."
Sweepstakes, Contests, and Promotions
To enter an online sweepstakes, contest, or other promotion (collectively, "Promotions"), you may be required to first register on a Cequent Website. The information collected as part of a Promotion is used to determine your eligibility, notify you whether you are a winner, and/or fulfill and deliver prizes. If you are a winner, certain information about you (such as your name and picture) may get posted to the Website.
For more information about Cequent Promotions, please see the official rules or details posted with the specific Promotion.
Message boards and other interactive features
We may provide interactive features that allow you to post or publish messages, stories or pictures on our Websites. Although we strive to protect those who use and participate in these activities, we encourage you to be wary of giving out personal information or images about yourself in public areas such as on a message board or other online community-type feature. Such information can be collected and used by people you don't know. As such, we cannot guarantee the security and privacy of, and are not responsible for, any information you post in these areas. Your use of these features is at your own risk.
Please note that if we choose to post a picture or message that you provide us through one of these features, we may post, along with the picture or message, certain non-personal information about you, such as your username, first name, first initial of your last name, and/or city and state of residence.
Purchasing Cequent products online
Some of our Sites may allow you to purchase Cequent products through an online shopping system operated by Cequent or by a vendor on our behalf while certain products may only be available through third-party retailers. Cequent provides links to unaffiliated third party sites that sell Cequent products. If you are purchasing a product through the Cequent online shopping system, you will be asked to provide your credit card information, including credit card number and billing and shipping addresses, as well as other basic contact information (e.g., phone, email address). This information is used to fulfill your purchase and confirm your order.
If the online store you are visiting is operated by an unaffiliated third party, we may provide you a direct link to the third party store for your convenience. Please note, however, that these sites are not operated by Cequent and are not covered by this Privacy Policy. We are selective in who we choose to partner with to sell Cequent products online and we will strive to work with online retailers who (like ourselves) use industry-standard encryption when collecting and processing orders through their websites. This helps prevent unauthorized electronic access to sensitive financial information, such as your credit card number. We encourage you to read the privacy policy of the online store you are visiting before sharing any personal information such as your credit card number.
E-cards, tell-a-friend, and other one-time use features
Personal information requested for an e-card, tell-a-friend or other referral feature, or other one-time use features (typically, names and email addresses) is used on a one-time basis (e.g., to send the communication) and is not further retained by Cequent. If these kinds of features are made available to children under 13, they may be designed so that prior parental consent is not required.
Business-related information
Please be advised that in some areas of our Websites, you may be able to submit information about yourself or the company you represent in a business capacity. These areas may include a career section where you can submit a resume or job application online or a section or contact form to handle media requests. Although any personal information gathered in this context is used exclusively for its intended purpose (e.g., a resume will be used for the job application process only), such information is not otherwise subject to the terms of this Privacy Policy.
What happens if you refuse to provide your personal information?
If you choose not to submit any personal information when requested, you may not be able to participate in certain activities and personalized features on our Websites and may limit the services and special offers we can provide you. For example, if you refuse to share your email address, you will not be able to receive any of our newsletters or otherwise register on our Websites. If you refuse to provide your credit card number, you will not be able to purchase products. However, to simply browse our Websites and learn more about our products, you do not need to give us any personal information.
Do we use cookies, track IP addresses, or use other passive means to collect information?
We use cookies to improve the use and functionality of our Websites. A "cookie" is a small file or record-keeping device that websites often store on a user's computer. Storage of cookies on your system provides an easy and convenient way for us to personalize or enhance your experience on our Websites and to make your next visit more enjoyable.
IP Addresses
We may keep track of Internet Protocol (IP) addresses to (among other things): (i) troubleshoot technical concerns, (ii) maintain website safety and security, (iii) restrict access to our Sites to certain users, and, (iv) better understand how our Sites are utilized. An IP address is a number that is used by computers on the network to identify your computer every time you log on to the Internet.
Log Files
We (or a vendor on our behalf) may collect information in the form of logs - files that record website activity and gather statistics about web users' browsing habits. These entries are generated anonymously, and help us gather (among other things) (i) a user's browser type and operating system, (ii) information about a user's session (such as the URL they came from, the date and time they visited our Site, and which pages they've viewed on our site and for how long), and, (iii) other similar navigational or click-stream data. We also use information captured in log file for our internal marketing and demographic studies, so we can constantly improve and customize the online services we provide you. Log files are used internally only, and are not associated with any particular user.
Web Beacons
We may use web beacons (or clear GIFs) on our Websites or include them in the e-mail messages we send you. Web beacons (also known as "web bugs") are small strings of code that provide a method of delivering a graphic image on a web page or in an email message for the purpose of transferring data back to us. The information collected via web beacons may include some of the information described in the IP Address section directly above, as well as information about how a user responds to an email campaign from Cequent (e.g., the time the email is opened, where does the user link to from the email, etc.). We use web beacon information for a variety of purposes, including but not limited to, site traffic reporting, unique visitor counts, advertising and email auditing and reporting, and personalization.
Who is collecting your personal information and is it shared with anyone?
The information that you disclose on the Cequent Websites is collected by Cequent or by a vendor acting on its behalf; and is used in accordance with the practices set forth above. The following provides more specific information about how and to whom we may disclose your information.
Agents and Contractors
We may use outside companies, agents, or contractors ("vendors") to provide support for the internal operations of our Websites and to assist us with administering the Cequent online shopping system or the various programs and promotions available on our Sites. In the course of doing so, these vendors may come into contact with your personal information. However, we only give them access to (or allow them to collect on our behalf) the information they need in order to perform the specific tasks they've been hired to do. They have also agreed to protect the confidentiality and security of this information.
Partners and Joint Promotions
From time to time, we may run a joint or co-sponsored program or promotion on our Websites with another company, organization, or other reputable third party; and, as part of this event, collect and process personal information. If your personal information is being collected by (or is shared with) a company other than Cequent as part of such promotion, we will let you know this at the time your information is collected. Periodically, we may run a promotion on our Site that features the products or services of another company and will give you the opportunity to opt in to receive information directly from that third party company
When doing any promotion involving another company, we may provide a separate link to that company's privacy policy and we encourage you to read it before you share any personal information, as we cannot guarantee they adhere to the same privacy practices. If you do not want your information to be collected by or shared with a company other than Cequent, you can always choose not to opt in or participate in these events at the time the information is collected/requested.
Your California Privacy Rights
If you are a California resident, you may have the right to request and receive certain information about our disclosure of personal information to third parties for their direct marketing purposes, and your choices with respect to such disclosures. However, our policy is not to share your personal information with third parties unless you first opt-in to such disclosure or are first given the opportunity to opt-out. This practice is disclosed in the preceding sections of this Privacy Policy. If you still wish to learn more about our compliance with this requirement, you may contact us using the contact information provided below.
Legal and Business Transfers
We may also disclose personally identifiable information if we are required to do so by law, or if in our good faith judgment, such action is reasonably necessary to comply with legal processes, to respond to any claims, or to protect the safety or rights of Cequent, its customers, or the public.
In the event of a merger or acquisition of all or part of or Cequent by another company, or in the event that Cequent were to sell or dispose of all or a part of the Cequent business, the acquirer would have access to the information maintained by that Cequent business, which could include personal information, subject to applicable law. Similarly, personal information may be transferred as part of a corporate reorganization, insolvency proceeding, or other similar event, if permitted by and done in accordance with applicable law.
How can you ask a question? (Contact Information)
If you have any questions or comments regarding this Privacy Policy or our information collection practices, please
contact us
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text:
These comments will help you use the Criminal Justice System Handbook in the Suffolk County.
District Court and the town and village courts are the local Criminal Courts in Suffolk County. Where the Handbook refers to Criminal Court, in the five west end towns of Suffolk County you might substitute District Court.
There is no Central Booking facility. Generally, arrestees are processed in the precinct and brought to the District Court within 24 hours for arraignment.
The police department may decide to release you on Station House Bail once you are arrested. If you are able to make this bail, the police will give you an Appearance Ticket, telling you when and where to appear in court for arraignment. If you appear as directed, the police department returns the money posted as station house bail to you (though the court may decide to set bail on you at arraignment).
There is no Criminal Justice Agency (C.J.A.). The Suffolk County Probation Department interviews arrestees before arraignment and submits a ROR report to the arraignment judge.
At Arraignment, if you are able to hire your own attorney, the judge will not generally appoint a Legal Aid or 18-B attorney to represent you for arraignment only.
Arraignments are conducted every day of the year, including weekends and holidays. The arraignment courtroom is D11, which opens at 9:00 AM. There are no scheduled evening or night sessions for arraignments in Suffolk District Court.
Though bench warrants are signed for defendants who fail to appear as directed by the court, the District Court also notifies by mail of adjourned dates if the defendant does not appear. It is important to inform the court if your address has changed.
If you do not appear for a court date or to pay a fine, District Court may also suspend your drivers license in addition to or instead of issuing a warrant. When you do appear in court, you will need to pay a fee to lift the suspension from your license.
If the Grand Jury votes to indict you, your case will be transferred from District Court to County Court (in Riverhead).


text:
Shield Gallery 9109 - 9132
Here you will find coat of arms suggestions kindly submitted by DrawShield users. They are presented with the most recent shown first, earlier submissions can be found in later pages. Submissions may take up to 48 hours to appear.
There is also a list of submissions organised by title, and you can view the most recently liked entries here.
Click on each shield to see a larger version and to get more information about the blazon.
Please Help!
DrawShield is a Free service supported by its users.
If you can, please help cover the cost of the server, or just buy me a coffee to say thanks! All donations are greatly appreciated.Buy me a coffee


text:
As some of you know, I recently moved to Israel from the United States. The first year here was amazingly difficult, including cultural, linguistic and societal challenges. The hardest part for me was finding a group of friends. I'm a social being, and surviving with only the love and support of my immediate family was hard. However, there are strong similarities to entering and adjusting to a new community online and offline. Here are a few things I learned from living in a new land that can help anyone entering participatory media.
1. When your organization decides to "live" in an online space, start with language first.
Listen to the online conversations until you find those that relate to your viewpoint, language and sensibility. Are you an arts organization? Find others conversing about the arts. Are you an advocacy organization for clean water? Find others who are talking about environmental issues, clean water and topics similar in nature to the ones you want to discuss. When I joined Twitter, I chose a few people to follow who tweeted about social media and non-profit issues, and then I listened. I followed conversations, researched the participants, and found others on Twitter who also spoke "my language."
My mother tongue is English. Trying to communicate in Hebrew, of which I knew at most ten words upon arriving, did not make sense. Thus…I sought English speakers first. I listened for them at the park, public spaces, and joined the English-speaking community lists . In this manner, I found "cultural interpreters" that introduced me to the intricacies of Israeli life. I still call them (frequently) when I don't understand something here.
2. Network through friends from home.
When you join Facebook or LinkedIn or Twitter, the application asks your permission to search through your online address book and find your friends who are already members. This is great way to start. They will, of course, introduce you to others!
I arrived in Israel a list of ten or so people to contact. They were "friends of friends," and I honestly had nothing to lose by calling and meeting them. This was a bit like blind dating, and though not every contact became a friend, many led me to new friends.
3. Join groups.
Every virtual community has groups within it. Wiki groups, Facebook groups, Bebo groups, and Twitter groups, for example. Find groups that talk about what you care about. Listen to the conversations. Through these groups, you'll make connections to the individuals in the community, create identity and explore friendships. Online groups are a great place to ask your questions about the community culture; group members want to help you acculturate and make other friends online.
Joining groups proved to be quite useful in finding community here. I found organizations that meet in English and are related to my professional goals. I made some strong connections and again found "cultural informants and translators," this time in the business world.
4. Learn the language.
I previously posted a roundup of the social etiquette and cultural norms of each participatory media. By familiarizing yourself with the societal norms of each virtual community, you are learning its language. Did you know what a "tweetback" was before using Twitter? Did you understand what it meant to "Digg" something before using Digg? Who really is your "friend" on Facebook?
Obviously, in order to understand Israeli culture and people, I have to be able to speak the language. I currently take Hebrew classes, which gives me an introduction to the culture and the ability to truly enter Israeli society. I understand the uniquely Israeli word "friar" now. Unless I learn Hebrew, I will always be a an observer.
5. Community builds, one friend at a time.
The same is true of online communities. Commenting on others' blogs will lead them back to you. Adding content to a wiki and getting good feedback on it means that they are introducing you to others. People listen in on your Twitter conversations and want to follow you. Your work will eventually transform into friends and communities online.
After a year, I am finally seeing some of my hard work paying off. I have a small group of good friends that I adore, and I continue to pester them with cultural questions! Friends have introduced me to other friends, professionals have invited me to new professional networking groups. I am starting to find community here.
6. Most importantly, don't give up!
Many bloggers write about the first hard months of blogging: few readers, Google hasn't found the blog yet, no comments, and no blogger community of friends. They all say that it is lonely and hard, but it gets easier after that.
Everyone told me that the first year in a new country is the most difficult, and that it will get easier after that. What did that actually mean for me? I spent the first year here putting myself out there: finding new connections that sometimes proved valuable and often did not, working hard to learn a new language and familiarize myself with new societal norms, figuring out how to be myself in a new land but also blend with the societal expectations.
We're all Strangers In a Strange Land every time we join a new community. But we're all in it together!


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Main Content
410 IAC 7-21 Section 39 - Sanitary Operations; General Maintenance
The plant shall be maintained in a sanitary condition and shall be kept in repair sufficient to prevent food from becoming adulterated. Cleaning and sanitizing of utensils and equipment shall be conducted in a manner that protects against contamination of food, food-contact surfaces, or food-packaging materials.
Food-contact surfaces, utensils and equipment shall be cleaned as frequently as necessary to protect against contamination of food by performing the following:
Food-contact surfaces of equipment and utensils used for manufacturing or holding low moisture food shall be in a dry, clean and sanitary condition at the time of use. When the food-contact surfaces are wet cleaned, they shall be sanitized and thoroughly dried before subsequent use.
In wet processing, when cleaning is performed to protect against the introduction of microorganisms into food, food-contact surfaces shall be cleaned and sanitized before use and after any interruption during which the food-contact surfaces may have become contaminated.
Where equipment and utensils are used in a continuous production operation, food-contact surfaces of the equipment shall be cleaned and sanitized as necessary to prevent contamination.
Nonfood-contact surfaces of equipment used in the operation of food plants should be cleaned as frequently as necessary to protect against contamination of food.
Single-service articles, such as utensils intended for one-time use, paper cups, and paper towels, should be stored in appropriate containers and shall be handled, dispensed, used, and disposed of in a manner that protects against contamination of food or food-contact surfaces.
Cleaned and sanitized portable equipment with food-contact surfaces and utensils shall be stored in a location and manner that protects food-contact surfaces from contamination.
Sanitizing agents shall be effective and safe under conditions of use. Any facility, procedure, or machine is acceptable for cleaning and sanitizing equipment and utensils if it is established that the facility, procedure, or machine will routinely render equipment and utensils clean and sanitized.
Chemical sanitizers and other chemical antimicrobials applied to food-contact surfaces shall meet the requirements specified in 21 CFR 178.1010.


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Syria's security forces opened fire on Monday during a ackdown on opposition activists in the town of Houla in central Homs province, activists said. "Five residents, including a woman, were shot dead on Monday by security forces, who have been conducting a sweep in Houla since Sunday," the Syrian Observatory for Human Rights said in a statement, quoted by AFP.
Meanwhile, a 26-year-old man died of his injuries on Monday after being among a group of people whom security forces shot at the night before in the town of Irbin, near Damascus, the activist group said earlier.
Elsewhere, security forces also fired at hundreds of demonstrators in the towns of Qusayr and Talbisseh, in central Homs province, said the activist group.
On its part, Syria's state news agency SANA reported that four law enforcement members were killed and 18 others wounded in an ambush set up by "armed terrorist group" while on their way back to their unit at el-Dahiriyeh crossroads in Hama.
An official source at the governorate told SANA that gunmen opened fire at two buses carrying law-enforcement forces near the crossroads, causing one bus to crash.


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Star Cookie Christmas Personalized Kitchen Towel
Regular price $8.99 Sale price
Perfect for holiday baking with your kids & grandchildren! We love family traditions in the kitchen. Perfect to add some festive fun to your cabinets, stove or dishwasher. Or use for a decorative basket liner.
Enter personalization with care - your towel will be printed exactly as you enter it. Our design team does not take any liberties in changing personalization.
Kitchen Towel Details:
- Waffle Weave towels measure 16" x 24".
- Kitchen towels are machine washable, super absorbent, & lint-free.
- Designs are printed directly on the poly blend fabric, so there will be no textured vinyl that will peel or crack.
- Kitchen Towels are made to order. Please note that the actual print colors may slightly vary from those seen in the listing photo due to variations in monitors and the printing process.
- If you have a custom request, let us know in the Notes section at Checkout.
- Designed, printed and shipped from the USA.


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March 28, 2009
Clearly Vintage
I just wanted to do a plug for an awesome blog that is centered around vintage. Cora has lots of nice images as well as a nice vintage stamp line that she sells at her Etsy Shop. I failed to ask her if I could borrow some images to place here to show you, so since I did not ask permission I will just direct you to her blog and on her blog she has her link to her shop. So if vintage is your thing or not; you should check it out and tell her Nina sent you! :O) Her blog is linked in this title, but here it is too: http://www.clearlyvintage.blogspot.com/
Posted by Nina at 10:38 PM
Labels: stamping, stamps, vintage, vintage stamps
1 comments:
- Cora said...
Thank you for the link to my blog. I really appreciate it.
- March 29, 2009 at 7:03 AM
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Originally published as "The World's Greatest Invention" in Approaching Magic, it's not a card trick, and not a coin trick. It's baffling, amusing, and astonishing. It can be performed for a room filled with sophisticated adults or at a kid show.
On top of that, the method is one you will love.
Imagine handing one spectator a glass of beer (or any beverage), and another a simple straw mat. You take back the glass of beer, hide it behind the mat for a moment... and it vanishes.
You show both sides of the mat - the glass of beer is simply not there. Then you reach behind the mat and produce the glass, still filled with liquid.
You repeat the vanish twice more, escalating the impossibility and further confounding the audience. You shake the mat - no glass, no beer. You turn the mat sideways, roll it into a tube... and reproduce the glass of beer to a guaranteed ovation.
The glass is not gimmicked (use you own glass), nor is the liquid or the mat... but there is a gimmick and it has been beautifully realized.
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Historian Davis wins Holberg Prize
Historian Natalie Zemon Davis, a Princeton professor emeritus, has been awarded the Holberg Prize, a major international honor established by the Norwegian parliament to recognize outstanding scholarly work in the arts and humanities, social sciences, law or theology.
Currently an adjunct professor of history and medieval studies at the University of Toronto, Davis will receive an award of $785,000 with the prize, which was established in 2003.
Davis is Princeton's Henry Charles Lea Professor of History Emeritus and served on the University faculty from 1978 to 1996. She is a pioneering scholar of the social and cultural history of 16th-century France and early modern Europe, with a focus on uncovering the lives and values of peasants, artisans and women. Her work is widely read outside of academic circles, and she has a long history of political activism in civil rights, women's rights and issues of free speech.
Davis' books include "Society and Culture in Early Modern France" (1975), "The Return of Martin Guerre" (1983), "Fiction in the Archives: Pardon Tales and Their Tellers in 16th-Century France" (1987), "Women on the Margins: Three 16th-Century Lives" (1995), "The Gift in 16th-Century France" (2000), "Slaves on Screen: Film and Historical Vision" (2000) and "Trickster Travels: A 16th-Century Muslim Between Worlds" (2006). "A Passion for History," a book of conversations about her life as a historian, will be published in May.
Davis, who directed the Davis Center for Historical Studies at Princeton from 1990 to 1994, was awarded an honorary degree by the University in 2003. She also has taught at Brown University and the University of California-Berkeley, and served as president of the American Historical Association.
She will receive the Holberg Prize at a ceremony on June 9 in Bergen, Norway.


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Republicans in the Senate made some significant changes to their tax plan Tuesday night, altering both the fiscal math and the political calculus of their effort to reform the tax system. Perhaps most important in terms of the legislation getting enacted, the new version of the bill shows revenues becoming positive in 2017 according to an analysis by the Joint Committee on Taxation, a crucial litmus test facing the Senate as it aims to pass the legislation with a simple majority vote.
The updated bill tweaks the proposed seven tax brackets and expands the proposed tax breaks for pass-through businesses, though it would have those breaks sunset after 2025. Here are five other critical components of the revised bill:
1. Obamacare mandate is effectively repealed. The bill would eliminate the penalty created by the Affordable Care Act for not having health insurance, effectively repealing the individual mandate that applies to all Americans. The federal government would save an estimated $338 billion over 10 years as millions of people forgo insurance, and that money would be used to help pay for the tax cuts.
2. Individual tax cuts are temporary. Tax reductions for individuals, including the doubling of the standard deduction and the repeal of the alternative minimum tax, would expire at the end of 2025. This move would allow the bill to satisfy the Byrd Rule, which forbids deficits beyond the 10-year budget window for legislation passed through the reconciliation process. Critics are dismissing the move as a gimmick, charging that Republicans are expiring the individual tax cuts on paper while betting that the cuts will actually be extended when the time comes in 2025.
3. Corporate tax cuts are still permanent. Tax cuts for businesses face no expiration — providing Democrats with ammunition for their assault on the bill and what it says about GOP priorities. Sen. Ron Wyden of Oregon tweeted Wednesday, "The #GOPTaxPlan is an economic double standard with the middle class losing out BIG. Corporate breaks are locked in place, key thrown away – but what they are giving families is only TEMPORARY."
4. Child tax credit increased: The revised bill raises the child tax credit to $2,000 per child, higher than the $1,650 defined in the previous bill and twice the current level. The credit would be available to families earning up to $500,000 a year. This move should please GOP Sens. Marco Rubio and Mike Lee, who called for a larger child tax credit, although the expiration of the credit after 2025 could be an issue. Analysts at the liberal Center on Budget and Policy Priorities point out that because the credit is not refundable, well-to-do families would see much larger benefit than millions of parents working in low-wage jobs.
5. A new measure of inflation remains in the bill: Both the House and Senate bills call for tax brackets to be adjusted for inflation each year using an index known as "chained CPI" rather than the standard Consumer Price Index currently in use. Chained CPI typically defines inflation at lower levels, which means that brackets and credits will increase more slowly over time. The move would raise more than $130 billion over 10 years, but the cost is not borne equally, with lower-income families feeling the pinch more than wealthier ones. Most critics agree that chained CPI is a more accurate measure of inflation, but the political optics of the change are hard to deny. "Fairly or not, the use of the new inflation index makes it harder for the Trump administration to fight off criticism that this tax reform benefits the rich much more than the rest," writes Grep Ip of The Wall Street Journal.


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This programming assignment is about pi, you know: 3.14, and all that. You probably know someone who memorized some of its digits back in seventh grade. There are the 3.14 people, just about everyone, then there are the 3.14159, people, and finally there are the elite memorizers, who went to 3.14159265, and beyond. Pi is hard to memorize because its digits are seemingly random, and this assignment takes a first baby step toward assessing the randomness of number's digit pattern.(Click here for an accessible discussion of the nature of the digits of pi.)
I've included a link to a text file that holds the first 100,000 digits of pi: digitsOfPt.txt
Your job for this assignment is to read through that file and then build and display a table that reports the frequency of each of the digits 0 through 9. Your table should look like this:
0 10001
8 10271
9 9994
bad symbols: 123
There are some other requirements.
The file is actually slightly corrupted - it contains some symbols besides digits (spaces, for example). Your job as you read through the file is to skip over these, but also report how many non-digits there are in the file. To do this you can use Java's try-catch construction.
Design arrays that most naturally use a non-numeric indexing scheme (here: the digits '0' through '9').
Your solution must use inheritance.
You must have a two class solution, a driver called PiDriver, and a principal class called PiCounter..
SO the file is called digitsOfPt.txt
and i need a PiDriver and a PiCounter
if ANYONE could help with this i would APPRECIATE it a LOT.
ALSO: it is due at 11:45pm EST tonight (July 31)


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When I was first starting out with the Piaggio conversion, I was monitoring my power consumption using a Doc Wattson / Watt's Up. Good for checking on amp-hours used, voltage, etc.
A few weeks into the conversion, I dropped my bike chain on the Doc Wattson and broke the LCD glass. Very annoying -- they should provide a lexan cover on things like this that will get banged around.
I asked the manufacturer if they did repairs and they didn't. I asked them for the spec on the LCD and they said it wasn't divulge-able. They did give me a discount on my second one and I threw the old one in my "crash" bin.
Well, fast forward a few months more and I've been working with STAMPS and PICs and know a bit more about LCD screens -- especially how most 16x2 displays are driven using the same HD44780 IC chip.
Time to open the Doc Wattson up and see what's in it.
More after the jump


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ePHOTOzine's Micro-Site Roundup - Find out what's been happening on our five Micro-Sites.
Here's a roundup of the exclusive content we've got for you to have a read of on our five micro-sites this week:
On PENTAXPORTAL this week, you can take a look at some top tips for photographing seals with your Pentax camera, and check out some top Pentax sunset photos. Plus, the brand new K-3 DSLR has been reviewed on site this week, and there's news of new images from Ricoh Imaging brand ambassadors.
Over On EIZO ColorZone, you can learn how to perform a monitor viewing angle check and find out why ColorNavigator software is a great tool for aiding calibration. Plus, there's news of a new 3D CG colour management handbook that's now available.
Meanwhile, on Olympus Image Space this week, there are techniques on how to use blur creatively, and there's news on Olympus workshops taking place over the coming months with Damian McGillicuddy and Steve Gosling. Plus, news on the Olympus Impressions 'Fall' competition, and £100 accessory cashback when you buy an Olympus OM-D E-M1 camera have also gone live.
On Totally Tamron this week, you can learn some top tips for taking better photos of ice with your Tamron lens, plus there are some top Tamron portrait photos for you to take a look at. Don't forget to take a look at David Pritchard's blog the days zoom past, too, as he's been out-and-about with his newly acquired Tamron 24-70mm lens.
Last but not least, on Nikon Nation this week, you can check out some ideas and tips for on location portrait shoots, get creative with colour balance and lots more. Plus, don't miss the Nikon D5300 Black Friday Deal DSLR review and news of ono-to one training with Nikon School in December.
Make sure you check back to the Micro-Sites regularly, as new and exclusive content is posted weekly!
Source: Ephotozine