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Dishwashers were once thought to be a luxury. But gradually it has evolved into more of a necessity in various households. They are very able in saving time and keeping the utensils and cutlery hygienic and clean.
Category: Large Appliances
Setting the right temperature for your commercial dishwasher is very important. There are two types of temperature settings according to the American National Standards Institute (ANSI) and the National Sanitation Foundation (NSF). The first one is low-temperature dishwashers with chemical sanitizing. The second is high-temperature with hot water sanitizing. You need to be familiar with the federal state standards to ensure you don't violate any health protocols.
You can mop your floors and wipe down the counters on a daily basis, but if your appliances aren't clean, your kitchen isn't going to look the way you dream it does. Whether it's a blender for smoothies or an oven for a pot roast, your kitchen appliances come in handy almost every day. So naturally, they'll get dirty from time to time and need a bit of elbow grease to knock off some of the larger, built up messes that come from use.
How much did you pay for your kitchen appliances? Do you feel as if it was a fortune? High-quality kitchen machines are expensive. When you make such an investment, you want to enjoy worry-free use for years to come.
If you're looking for a new way to cook stove top meals, you may want to consider induction stove tops. Of course, there are pros and cons to any type of cooking tool, but the benefits of induction-style stove tops will take your cooking experience to a higher level.
You can come up with some pretty tasty foods if you own a charcoal grill, not to mention about gas grills. However, nothing compares to the real thing – a specialized electric smoker. With the modern smoker and a little experience, your food is about to adopt a brand new taste. No matter what type of recipe you rely on, you can easily raise to the quality standards from a restaurant. Forget about hovering over the grill for four hours and monitoring the temperature round the clock. Forget about shoveling coals and adding new wood all the time. Instead, the smoker will put the perfectly tasting food on your table in no time, without feeling like it is over or under cooked.
For many, especially serious cooks, having a range in the kitchen that can do almost everything a commercial range can do is high on the kitchen wish list. Not only do pro-style ranges offer the power and performance to meet all varieties of cooking needs, they have a look and feel similar to restaurant equipment, which in itself adds to their appeal. But with these ranges usually starting around three thousand dollars and sometimes costing as much as a new car, it's worth taking a look at what features set them apart from a typical gas range.
How To Clean Different Types Of Ovens
Chances are you might be using your oven more than usually with the season at our doorstep. In order to make it work its best, the oven has to be clean. There are a few ways to clean the oven. The right cleaning method for you depends on the type of oven you have and whether you're looking for environmentally friendly methods. Here are a few different ways you can clean the oven in your kitchen.
This is a guest post by LocalTraders. If you want to guest post on this blog, check out the guidelines here.
Astonishingly, the average person spends between 18 months and two years looking after the home! Whether you spend your time dusting, vacuuming or cleaning up after your pets or kids, household duties are a chore and we are always looking to buy appliances that help maintain domestic bliss, allowing you to spend time doing something other than cleaning.
This is a guest post by Rose Marie Baker. If you want to guest post on this blog, check out the guidelines here.
With families becoming more eco-conscious, energy-saving kitchen appliances are exploding in appeal. Although such appliances are still a little on the expensive side, families are attracted to conserving electricity and gas, generating less pollution and protecting the environment. Furthermore, the U.S. government, at both the state and federal levels, entices families to buy energy efficient kitchen appliances by rewarding them with incentives, such as rebates. These coveted appliances can reduce the amount of water families use, shrink electricity bills and even help manufacturers use less new construction materials because a high percentage of energy-saving appliances use recycled materials and sustainable materials.
Tips For Keeping Your Oven Squeaky Clean
This is a guest post by Ryan Hirst. If you want to guest post on this blog, check out the guidelines here.
In every home the oven is one of the most used pieces of equipment, but on the same time can be the most strenuous to look after. With moves in technology in the kitchen we see modern items like fridges with many different gadgets in built, but your oven will not have advanced too much – and will definitely be the one which gives you the most sleepless nights when it comes to its maintenance!
Cloudy White Residue On Your Dishes?
This is a guest post by Jody Tompson. If you want to guest post on this blog, check out the guidelines here.
If you live in an area with hard water, you have probably noticed a recent change in the performance of your dishwasher. Specifically, your dishes might have a white film or residue on them after they go through your automatic dishwasher. In addition to looking dirty, these "clean" dishes can also feel gritty or sandy when you handle them. Some people have grown quite frustrated because they have been unable to find a solution to this problem. One week the dishwasher was working fine, then, in a matter of a few days, the dishes began looking terrible.
Best Dishwasher For Your Home
This is a guest post by Katie Campbell. If you want to guest post on this blog, check out the guidelines here.
Gone are the days when a dishwasher was a luxury amenity. Whether a person is looking to buy or rent a home, a dishwasher is always on the must-have list. Preparing to purchase a new appliance is no easy task. There are spec sheets, special pricing and sales to sort through. The most important elements of a dishwasher are washing ability, energy efficiency, load time, and noise level. Keeping those key factors in mind, buying the best dishwasher gets much easier.


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The Best (and Worst) of Recruitment Communications
For Professional and Continuing Education Leaders
Unfavorable demographics and a difficult economy will require undergraduate enrollment managers to abandon one-size-fits-all recruitment communications. In order to benchmark current undergraduate recruitment communication practices, we secret shopped 133 colleges and universities — of which 127 bothered to respond. What we found was a lumbering follow-up process with an overreliance on email that was often poorly conceived and executed, and few attempts to actually respond to our prospective student's interest. Of 1,120 emails and print materials we received, only 41 messages were specifically tailored to our shopper's stated academic interest. And while print letters were signed by real people, we found just 41% of the more than 800 emails we received contained an identifying signature, and only eight percent were sent from a real person's email address.
To compete for student mindshare going forward, it is time for colleges and universities to use technology to increase personalization and relevance and reject one-size-fits- all "unique" messaging. Underlying this approach should be a focus on helping prospective students make decisions and developing a supportive and coordinated cross-channel conversation plan.
In this research report, discover the best and worst practices of undergraduate enrollment managers and marketers today, study the anatomy of bad email, and discover our recommendations to break the bonds of irresponsible email marketing.

subset: commoncrawl


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Candidate Name
Aaron Matteson
Which office are you seeking?
Assembly Representative-District 22
Campaign website and/or social media links
1. Do you support a legal, regulated, and taxed market for recreational cannabis, allowing Wisconsin residents over the age of 21 to purchase and possess up to two ounces (or more) of cannabis from regulated dispensaries, as proposed by State Rep. Melissa Sargent's (D-Madison) AB482?
2. Do you support allowing any Wisconsin resident over the age of 21 to grow up to 6 (or more) cannabis plants at home without a license, as proposed by AB482?
3. Do you support allowing patients suffering from various ailments to purchase and use cannabis as treatment for their ailments if they have a doctor's recommendation?
4. Do you agree with the qualifying conditions for medical cannabis outlined in Section 42 of AB482 (listed below)?
(2) "Debilitating medical condition or treatment" means any of the following: (a) Cancer; glaucoma; acquired immunodeficiency syndrome; a positive test for the presence of HIV, antigen or nonantigenic products of HIV, or an antibody to HIV; Crohn's disease; a hepatitis C virus infection; Alzheimer's disease; amyotrophic lateral sclerosis; nail patella syndrome; Ehlers-Danlos Syndrome; post-traumatic stress disorder; or the treatment of these conditions. (b) A chronic or debilitating disease or medical condition or the treatment of such a disease or condition that causes cachexia, severe pain, severe nausea, seizures, including those characteristic of epilepsy, or severe and persistent muscle spasms, including those characteristic of multiple sclerosis. (c) Any other medical condition or any other treatment for a medical condition designated as a debilitating medical condition or treatment in rules promulgated by the department of health services under s. 50.81 (2).
5. Answer this question only if you support both recreational and medicinal uses of cannabis. Do you support allowing medical cannabis patients to possess more cannabis than recreational users and to be exempt from the taxes that are imposed on recreational users?
[No response]
6. Do you support a permitting system that would enable publicly-accessible establishments to allow legal possessors of cannabis to smoke it in outdoor areas at their establishments? This would address an issue present in other states' implementations, where many people are legally allowed to purchase and possess cannabis, but have no place to legally consume it.
7. Do you support conviction expungement or pardons for anyone convicted of possession, growing, and/or selling cannabis in Wisconsin?
8. Do you support or would you consider any other cannabis regulatory or legalization scheme for Wisconsin
Release from incarceration if possession is the only charge or if was one of the three offenses in "Three Strikes And Your Out" policy.
9. Do you believe that possession of limited amounts of cannabis by a person in his or her own home or in another's home with the owner's permission should be legal in the State of Wisconsin?
10. What level of taxes do you think should be imposed on recreational cannabis?
Same as Colorado's
11. How do you think that tax revenue should be used?
12. Why is cannabis law reform an important issue to you?
It is known to help those in pain and is not harmful.
Additional Comments
My opponent, incumbent Republican Janel Brandtjen is against medical marijuana.


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SEO and SMM Alert- 5/10/13 Edition
Lindsay's FAV SEO and SMM Alerts- 5/10/13 Edition
Weekly WordPress Plugin: "HipMob" Live Chat for your Site
Hipmob is the fastest live chat service for your WordPress site. Talk to your visitors/users, transform user support and increase sales and conversions. Make your visitors happy with Hipmob hosted live chat! You can install, customize and activate the Hipmob for WordPress plugin with just a few clicks; no servers or software to install.
Beyond Search Rankings: Using SEO to improve Site Optimization
The evolution of search engine algorithms has added to the complexity of search engine optimization. More significantly, it has impacted the level of integration that is needed with other forms of Web optimization. SEOMoz has a great page that shows the updates year by year
26 Social Media Marketing Tips from the Pros
Are you looking for actionable tips to improve your social media marketing? Are you wondering what the common themes of social media experts are these days?
Thrifty Digital Marketing Strategies for Greater Search Engine Optimization
My site audit OCD boils down to a low budget method of learning new ways to utilize and incorporate advanced tactics into my digital strategies, making full use of resources that are available to me. Since digital marketing encompasses many different actions, every experience can be re-channeled into strategies or offer insights into how actions can be improved upon.
Free Ways To Reach More People On Facebook
It's been interesting to see the increase in social media ad spending as of late. A recent study based on a survey of over 500 online marketing and media professionals throughout the U.S. revealed that 64% of them planned to increase social media spending by as much as 10%! With over 650 million daily active Facebook users as of March, 2013, which is a 26% increase year-over-year, this budget increase makes some sense.
Great tips to capture your audience through your headlines!
Social Sharing Boosts Email Results
Think that social media has killed off email? Hardly. Active email users far outnumber users on any social network. For example, 3 billion people use email. Now compare that number with one billion Facebook users, 200 million Twitter users, and 200 million LinkedIn users.
How to Integrate Ratings and Reviews Into Your Social Marketing Programs
Positive ratings and those 5-star reviews from online consumers are powerful marketing content. Some 70% of Americans say they look at reviews before taking the next step to conversion, and 51% of consumers say they would never buy a large electronic item, such as a TV or computer, without reading at least one piece of user-generated content.


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Introduction: Magnetic Wireless Charging Hack to Any Smartphone for Free !!!
Let's Make any smartphone or old cheap phone wireless charging compatible with this hack with just 4 magnets ! Absolutely free of cost to make with homemade things you have right now !
Smartphones are getting smarter in every aspect but the charging it with a cable still feels like the world is stone age ! so today we will take any old cheap phone into a wireless charging cellphone Just Place it on your desk and there it goes charging !
So lets get started !
Watch me Doing This Hack Here
Step 1: Get Your Hand Busy !
★☆★ Buy Parts from your online local store ★☆★
Buy Neodymium Magnets http://geni.us/bQRy0
1. First, open your cellphone carefully
2. Safely remove the battery and other components
3. Then connect Your charger and identify the polarities of micro-usb port
4. Use the soldering iron with the smallest tip to solder red wire to positive and black wire to negative (This is Important Step )
5. Now confirm the connections are done properly with using multimeter
Step 2: More Work to Do !
1. Take out the wires you just soldered
2. Fit your phone "Like a Boss !"
3. Mark two holes according to size of your magnets
4. Now drill a small hole on to the back panel of a phone ,with a dremel tool
5. scissors can be helpful to make hole larger
6. Solder Wires on to the magnet with diffrent poles But Don't put your soldering iron for too long otherwise magnets will be useless
7. Make sure magnets work good
8. You can almost make it as flat as your back panel
9. Now hot glues two magnets to your desk in right polarity and keep some wire to move freely
Step 3: Magnets Attract ! What's More...
Un-like poles of magnet attracts each other so if we solder wires to a magnet , we will get a wireless charging connector which automatically engages when cellphone comes in vicinity !
Next, You can integrate this feature into your power bank so just put your phone near power bank & Get it to charging !
Step 4: Keep in Mind !
Magnets attract any metallic piece so if your desk is filled with all kind of metalic stuff be careful it may short circuit the charger
Manufacturer Warranty will be void on your device
Anyways its fun and useful Hack.
Get me some treats by your sharing and support ,Thanks!
Check out my other crazy DIY's
# How To Make See Through Camera !
# Facebook https://www.facebook.com/pages/Kedar-Nimbalkar
# Twitter https://twitter.com/kedar264
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43 Discussions
I appreciate the experimental spirit. But i must call you out on the very naive and shortsighted assumptions you have made. The recent coverage of the Samsung battery fires should serve as a warning about the energy potential these compact and powerful batteries have. Samsung got it wrong TWICE with the original and the replacements and their resources for test far exceeds yours.
My 2 cents about this Instructable... I know cellphones very well, working for a big phone manufacturer for almost 10 years; telecom engineer for more than 20 years. First, cutting back a cover may cut one or more phone's antennas, as you may find them there printed inside the cover for WiFi, BT, NFC and even from an eventually existing wireless charging system... I've also read people warns about accidental short-circuits and they're right, very likely to happen, but my real warning is about SAR (specific absorption rate), which is the radiation from the cellphone that is absorbed by human body. Any change (and I mean ANY) you make in a cellphone could potentially change the radiation but including metal parts, magnetic or not, in the cellphone will certainly change it dramatically. You might be creating kind of a tunnel of radiation concentrating the way out in two points: the magnetos external ends. While inside your pocket it might concentrate radiation in these two points potentially exceeding the cancer-safe limits recommended by the ICNIRP (International Commission on Non-Ionizing Radiation Protection - an organ linked to the United Nations Organization). Besides, microwaves may burn your inner flesh layers, where there's no nerve endings to feel pain. While original cellphones are reported safe to these two effects, any mod on them may (and will) change radiation path. This is really serious so I firmly advise you not to promote this kind of changes in a cellphone, otherwise you're assuming a serious risk of getting cancer or maybe burn part of your body without feeling pain.Believe me, this is really dangerous... My 2 cents... :)
Can you suggest a way to test the safety? People are still going to do projects like this. Maybe you can make an instructable on how to safely make changes to a smartphone.
What a coincidence I just got only has negative things to say, and doesn't suggest any other possibilities or safety advice.
Safty is for the weak... oxygen is for the losers... and sleep is for the poor... go for it. There are things you think are impossible because that's what they taught you... if you learn anything it's to pass on the knowledge to your kids, anf their kids, and their kids. Cremember... "Compation with Evidences". Don't follow unless you've walked the path alone. This guy probably works for them.
Actually no... SAR testing is something too complex to be done outside high level labs and costs thousands of dollars. As an example, if a company manufacture a cellphone it has to be tested. If a headphone is provided with the phone, the lab will test twice, with and without the headphone connected. Same for cover and any other accessory. A headphone is something used outside the cellphone, can you imagine the impact of changing something inside it, in special if you're adding metallic components? In short, there's no easy (and cheap) way to find out the impacts of changes in a cellphone without those expensive tests. Sorry... ;)
But if SAR is already happening then whats the point of not doing it already? Besides, if this was possoble how much would you think these companies pay to keep me quite?
interesting... but no risk no fun?
If your definition of "fun" includes the risk of getting cancer, starting a fire or having your inside flesh being burnt, this mod could be fun. Mine definition is way different... But trying it is up to you. Have fun, get safe! :)
Great idea but,
won't the magnet damage the phone? corrupt data? vibration and other magnet sensitive parts
The phone itself has magnets in it. The speaker, the motor for the 'vibrate' function. As for data corruption, no. You're thinking of magnetic-media storage devices, like spinning-disk hard drives, floppy drives, and tape drives. Phones use flash memory which is not magnetic in nature and therefore not affected by normal magnetic fields.
the phone as some magntic components. But not random stuff put in random places.
It will effect also your wifi-phone signal. For example.
And. what happen if u short circuit the 2 magnet with something metallic? ( like a coin, that is attracted to them? )
What happen to a magnet whit a current flow?
etc etc etc
I agree that randomly installing certain items would probably hinder the phone's operation. I was mostly addressing concerns about data storage.
While this is largely true, I imagine any compass functionality would be ruined since the magnetic field from the magnets would interfere with readings of the earth's magnetic field.
More importantly, this is very easy to short which could cause problems.
and As last thing
But there are no wires therefore it is wireless
the wires are connected to the table and in the phone itself
But there are wires!
They just look like round magnets so you think they arent wires...
But they are...
Anyway if u'r opening the case and soldering, why not solder a wireless coil reciever?
I'm glad I learned how to solder wires wirelessly.
yea exactly! this is not a wireless system. please consider how your phone could short circuit easily and people don't have money to just throw it around like that. \sure im gonna go and stuff up my phone and go buy a new one for like $400
if you have ever played a Wii (used to play it when i was younger) there are chargers that would have this panel and if you lined the remote up correctly with the place outlined, the remote would start charging, using the same idea would be really cool to create a charger that could actually work using wireless.


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3 Takeaways from the UFC's Release of No. 11 Ranked Welterweight Jake ShieldsApril 8, 2014
The UFC made the controversial decision to release No. 11 ranked welterweight Jake Shields on Monday. Shields had just lost a decision to Hector Lombard, but had beaten UFC contenders Demian Maia and Tyron Woodley in his two previous fights.
According to Trent Reinsmith of Bloody Elbow, Shields' manager Lex McMahon commented on the cut by saying, "To lose one fight and then all of a sudden be out of a job was something that I believe was surprising and not contemplated."
While Shields has had a long and successful career up to this point, he has been much maligned for his "boring" style of fighting—which features a lot of position control, particularly when he is on top of his opponent.
The UFC Won't Put Up with Boring Fighters
The UFC showed once again that they want exciting fights, first and foremost. There is no rational argument that could say that Shields does not deserve to be in the UFC based on his resume. Shields' recent wins over Maia and Woodley prove that.
However, Shields was never an exciting fighter. He was not the type of fighter that you would buy a pay-per-view for. Shields had that suffocating top control and persistent wrestling that made him very successful, but—quite frankly—pretty boring.
Shields' style was a type that only a few hardcore grappling fans could appreciate. It takes a high level of knowledge to appreciate the way that Shields holds down and positionally dominates professional mixed martial artists. This type of style is fine for a fighter, but they have to look to finish. Too often, Shields was in dominate positions in fights and failed to capitalize. Shields used beautiful grappling to get take downs and pass the guard, but that's where it ended.
Once Shields started to show that he was not a top-five fighter anymore, it was easy for the UFC to decide that the he was not worth the trouble.
The UFC showed that it doesn't tolerate boring fighters—no matter how talented—by releasing other so-called boring fighters like Jon Fitch and Yushin Okami. Shields was just another name to add to this list.
Shields Can Still Be Involved in Important Fights
Just because Shields is not under the UFC banner anymore doesn't mean he wont be able to put on meaningful fights. Shields still can fight a myriad of talented and up-and-coming fighters.
Shields can go fight against Ben Askren in OneFC and give Askren the meaningful competition that Dana White believes Askren needs.
A fight between Shields and Askren would definitely be an enticing matchup, especially in the grappling aspects.
Or maybe Shields can go to WSOF and test his skills against another UFC cast-off in Jon Fitch or the leg lock assassin Rousimar Palhares. While the fight with Fitch may seem to be a boring match of two subpar strikers with above average wrestling skills, the Palhares fight would be a fascinating matchup. It would be Shields and his position dominating grappling versus the ultra-aggressive, submission-centric grappling of Palhares.
The Palhares fight would be one of the biggest fights any promotion outside of the UFC could make. Palhares has the style of grappling that could lead to a very crowd-pleasing fight for Shields. The only question is whether WSOF could sign Shields and make the fight happen.
No matter which way Shields decides to go, he will have the opportunity to compete in meaningful fights.
Shields Has Almost No Shot to Get back into the UFC
Shields is a 35-year-old fighter with a style that often bores the audience. That is not a good recipe for a fighter to get back in the UFC. Shields is on the downside of his career, and it is very unlikely that he could reinvent himself into an aggressive fighter.
Shields has been in MMA since 1999 and still has a very average striking game, so it doesn't seem like he could become an effective striker any time soon.
Shields' only hope to become a more entertaining fighter is to take more risks while on top. He needs to attack for submissions more, which might leave himself a little more vulnerable than in the past.
However, that is very unlikely. Therefore, because of his age and skill set, it is unlikely we will see Shields fighting in the octagon ever again.


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For many many years I have had a novel SCHOOL AT THE FRONTIER by Geza Ottlik in my library. The novel was published by Harcourt Brace (A Helen and Kurt Wolff Book) in 1966 and in spite of coming from such a distinguished house it was not reviewed in the US.
Over the years via there is the gradually dawning realization that from Hungary were coming writers who have lead me to write: if James Joyce were alive today he would have learned Hungarian as he had once learned Norwegian and it is probably no accident that Bloom is of Hungarian origin.
Only the stupid or poorly read are unaware and have not read the books of Sandor Marai, Imre Kertesz, Peter Esterhazy, Peter Nadas and Laszlo Krasznahorkai...
The purpose of this brief post is to remind my few readers of Geza Ottlik whose writing and whose shadow is out of which come all of the writers I have just mentioned. It took me years to find a copy of BUDA and then the making contact with the translator who tells me that the version of School at the Frontier was cut and at times is a little incoherent and needs to be freshly translated and he took the first step by translating BUDA that came out after Ottlik's death...
I won't go into the complex history of Ottlik, who during the very darkest days in communist Hungary was not allowed to publish... but for days now I have been living with this paragraph centered upon the central voice in the novel which is an attempt to describe the place of Buda in the lives of the characters readers first met at that school they all attended so long as the nightmare of the 20th Century descended on Hungary and world--- and let no one think the 20th Century was anything more than another long murderous moment in the enduring --whatever you want to call human existence...
from the novel BUDA by Geza Ottlik:
..."my good friend, a writer in Buda, asks, "say BB how much longer are we supposed to live?"
---Listen, dear Bandi, dying is what I dread; me too, I'd like to get it over with. The sooner the better. (A man's life may be seen as a urological episode: blood, stool, urine at the beginning, and it seems, at the end as well.) Meanwhile you will need a little more time to finish what you have started. (or to leave it behind in some semblance of order...) I turned my unfinished canvas around to face the wall so as not to see it all the time, and be influenced by what was good in it; I need something totally different here, something I cannot fully see yet; I'll find it eventually. (By myself, in my head.) I will.
The bad stuff in the painting does not disturb me. What do I need here?...
From BUDA by Geza Ottlik translated into English by John Batki and published in Budapest by Corvina in 2004
Geza Ottlik wrote a brief article "On the Novel" from which...
"The novel attempts to create meaning on this side of language. How can it do this when it has nothing but language itself. First, language itself was born of a stratum on this side of language and is a derived system of signs referring back to that reality. Second, it is in itself a reality beyond language. For example, we simply retranslate its crude generalizations, its abstract functions, we assemble what it has torn apart and use it in its entirety. In the beginning was not the word but the sentence; it is this we break up into its component parts. In the beginning was not the sentence but the paragraph; it is this we expound into sentences! In the beginning was not the paragraph but the novel, and the novel was preceded only by silence itself."
Tuesday, September 24, 2019
Posted by Thomas McGonigle at 1:20 PM 3 comments:
Labels: GEZA OTTLIK, JOHN BATKI
Wednesday, September 18, 2019
Today, I went to look at art on West 24th Street in Manhattan
On looking again at a version I had left out writing between these two pictures but now I have done so
I am surprised by the content of some of these pieces of art.
Have I revealed myself in the taking of these pictures
The pictures were of art that was in the galleries on West 24th Street between 10th and 11th Avenue in Manhattan.
The above picture is of something that might be called a sculpture.
This picture above contains a "living" human being who is taking a picture. This was an accident.
I was looking at these pictures after noon on the 18th of September 2019.
I had one verbal exchange with people in a gallery as a woman excused herself for talking about going to the dentist and I said I didn't hear what you were saying so you don't have to excuse yourself. The woman explained that her father had been a dentist and she knew a great deal about dentistry--- all of which was in response, it seems, to a person who was behind the desk who it seems was complaining about going to the dental clinic at NYU where she had a procedure done by many students. I said I was just at the dentists and he is very good. A third woman asked for his name and I wrote it out on a small piece of paper. I told the first woman that I had been going to dentists since I was a child and the name of the dentist I went to in Patchogue was Dr. Pierce, a terribly foreboding sort of name I only realized much much later after I had left Patchogue and heard that the doctor had lost a hand by sticking into a lawnmower trying to dislodge something or other.
I am not sure what to call this something or other...
it comes from an artist working in Alexandria, Egypt. I do not think I can claim that he was inspired by the novels of Lawrence Durrell
Posted by Thomas McGonigle at 10:01 PM 2 comments:
Labels: MOMENT OF ART
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On Friday afternoon, the General Shareholders Meeting was held in the Amsterdam ArenA. One of the items on the agenda was the notification of the decision to re-appoint Marc Overmars and Jeroen Slop as directors of the company. This item was, per the statutes, not up for voting, but for discussion. The Supervisory Board proceeded with the formal re-appointment. Dolf Collee stepped down as General Manager and Chairman of the Board today. As has previously been announced, Edwin van der Sar is his successor, effective today, November 11, 2016.
During the Meeting, Ernst Ligthart was re-appointed to the Supervisory Board of AFC Ajax NV. This re-appointment was also formalized as of today, November 11, 2016. The three re-appointments will be valid for four years, until the end of the General Shareholders' Meeting in 2020.
Ajax's Management Team, as of today, consists of: Edwin van der Sar (chairman, statutory), Marc Overmars (player policy, statutory), Jeroen Slop (finance, statutory) and Menno Geelen (commercial, titular). Ajax's Supervisory Board consists of: Leo van Wijk (chairman), Theo van Duivenbode, Ernst Ligthart, Peter Mensing en Leen Meijaard.


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A few years ago, a television commercial asked, Who first believed in you?
Many folks may have instinctively answered by simply saying, Mom.
She was the first one there for most of us.
There was a time in most of our lives when Mom was our everything.
She made peanut-butter-and-jelly sandwiches for our lunches.
She cared for our scraped knees.
She readied our clothes.
She cleaned up after us.
More importantly, Mom was the one who often truly first believed in us.
When all that we would be or would become was the often childlike dreams and hopes of a child talking, Mom was often the one listening with encouraging words.
When those childhood dreams hit real-world obstacles, Mom was often the one to soothe our hurts, encourage us not to give up and push us to try again.
When others gave up on us, or abandoned us, or discouraged us, Mom was often the one who remained in our corner, who stayed with us, who supported us.
For so many of us, it was a woman called Mom who was the first to believe in us.
Mom was usually the one, too, who kept believing in us.
It was Mom who helped us believe in ourselves.
Sunday, May 10, is Mother's Day.
It is a day set aside to thank Mom for all that she has done for us through the years.
It is a day to thank the person who believed in us from our earliest days and who kept us and our dreams alive through the many days that followed.
Remember to tell her, Happy Mother's Day!


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Extraordinary Ministers of Holy Communion are authorized by the Church to help the priest with the distribution of Holy Communion when there are a high number of communicants at Mass. There are also opportunities available to distribute Holy Communion to the sick and to nearby nursing homes. If interested in this ministry, please contact Jason Zych at firstname.lastname@example.com or 412-833-5757.
Click here for the Extraordinary Minister of Holy Communion Policies and Procedures. (coming soon)


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Extended Services
Breakfast Club
COST: £3.50 per session
TIME: 8.00am - 8.55am
St Stephen's School Breakfast Club aims to provide pupils of all ages with a safe and fun place to start their school day.
The Breakfast Club is open to all pupils and we will do our best to accommodate the needs of your child. If your child has special needs/disabilities and requires extra support, please discuss this with Breakfast Club staff.
The club is informal and friendly, allowing children a choice as to how they start the day: some children like to wake up slowly, others prefer to get on and play. The club provides for both quiet space (for reading, etc.), and a free play area, as well as more structured activities. Play, rather than education, is at the heart of the club.
Each morning a nutritious breakfast is provided. The children are encouraged to help themselves, sit down and talk together and then clear up their dishes: the idea is that our breakfast replicates as far as possible the atmosphere of a family meal. At the end of the session, the children are well fed, happy and ready to learn.
Registering with Breakfast Club
Bookings can only be accepted for children who have registered for Breakfast Club. Registration forms are available from the school office. Completed forms should be returned to the office prior to booking your child's first session. Deposit and payment must be made prior to the first session – Via Simspay.
The breakfast club benefits from support from the Magic Breakfast Mayor's Fund for London Project.
Extended Day Care
For children from Nursery to Year 6
COST: £9 a day or £45 per week
TIME: 3.20pm - 5.45pm
Our qualified and experienced staff collect your children from their class at the end of the school day. We also do one off or short notice pickups.
St Stephen's C of E Primary School aim to offer exciting, stimulating, relaxed and homely environment for young children. We provide an opportunity for them to participate in a variety of stimulating activities of their interests and the opportunity to relax and rest whenever necessary.
We are committed to meeting the individual needs of all children. The welfare of the children is central to our provision of care, learning and play. All children are respected and valued and we provide experiences to support their physical, social, emotional and intellectual development in a warm, caring and secure environment.
Through carefully-planned activities, play opportunities and interactions, all staff continually promote children's self-esteem by supporting them in developing skills, knowledge and understanding, as they explore their world. Children are encouraged and supported in making choices and decisions as active learners. Their progress is monitored regularly in order to ensure that individual needs and interests are identified and provided for.
Registering with Extended Day Care
Bookings can only be accepted for children who have registered.
Registration forms are available from School Office.
Completed forms should be returned to the School Office, deposit and payment must be paid prior to the first session – Via Simspay.


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Oh my gosh, loved this. I tore through Katie Cotugno's debut novel in only a couple days!
This is a young adult contemporary novel, and it's told in alternating chapters of "before" and "after"– that is, before Reena's boyfriend/baby daddy vanished for two years and after he came back in her and their daughter's life. Interestingly, my novel Truest also does this back-and-forth thing, but it felt different than mine. How to Love was equal parts before and after, whereas the bulk of my novel is the before– the after is just tiny glimpses. Anyway, it was fascinating to watch how another novelist made this work for her so well. The hard thing about it though was switching back and forth. Just when I'd really get into either the before or after, we'd switch. Still, it drove the novel forward.
How to Love is really the story of Reena and Sawyer– but also a story about family and about failed friendships and secrets and drugs and ohmygosh really enjoyed this. If you like contemporary, go! Read! Enjoy!
P.S. If you do read this one, let me know. I have a couple things I want to discuss with someone!


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NJ County Pays Almost $50k in Gun Buyback To Get 15 "Assault Weapons" Off Street
Guns Save Lives is not supported by ads and is ran as an independent project. If you support this project please consider supporting us on Patreon. Registration takes just a moment and even $1 is a massive help in continuing our work. Thank you so much.
Officials in Morris County, NJ spent nearly $50,000 on a gun buyback program that netted 15 "illegal assault weapons" (you know, those weapons that are legal in almost every other state that doesn't have 'New' in front of its name or end in 'fornia')".
Sounds like an amazing use of taxpayer dollars (please note sarcasm).
There were over 600 guns collected. The rest included standard capacity handguns, revolvers, antique rifles, hunting rifles, shotguns and 33 BB guns (wouldn't want those kids in NJ to have too much fun).
The program was a no questions asked buyback with no arrests being made for the "illegal" weapons.
"This operation demonstrated, once again, the great success that can be achieved when law enforcement agencies act in collaboration with each other in their continuing efforts to protect the citizens of Morris County," Morris County Chief of Investigations William Schievella said in the statement from Knapp's office.


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Adversarial Perturbations in Biometrics: Detection and Mitigation
Date of the tutorial: Monday, October 22nd.
Time of the tutorial: 1:30 - 5:30 PM
Speakers: Mayank Vatsa, IIIT Delhi, Richa Singh, IIIT Delhi, Nalini Ratha, IBM TJ Watson Research Center
Abstract: Deep neural network architecture based models have high expressive power and learning capacity. However, they are essentially a black box method since it is not easy to mathematically formulate the functions that are learned within its many layers of representation. Realizing this, many researchers have started to design methods to exploit the drawbacks of deep learning based algorithms questioning their robustness and exposing their singularities. However, adversarial attacks on automated classification systems has been an area of interest for a long time. In 2002, Ratha et al. proposed eight points of attacks on a biometric system and several of these attacks are relevant for non-biometric classification tasks as well, including object recognition and autonomous driving. For instance, the adversary can operate at the input level or the decision level, and lead to incorrect prediction results by the classifier. Therefore, it is important to detect the adversarial perturbations and mitigate the effect caused due to such adversaries.
The research on adversarial learning has three key components: (i) creating adversarial images, (ii) detecting whether an image is adversely altered or not, and (iii) mitigating the effect of the adversarial perturbation process. These adversaries create different kinds of effect on the input and detecting them requires the application of a combination of hand-crafted as well as learned features; for instance, some of the existing attacks can be detected using principal components while some hand-crafted attacks can be detected using well-defined image processing operations. This tutorial will focus on these three key ideas related to adversarial learning (aka perturbations, detection, and mitigation), building from basics of adversarial learning to discussing new algorithms for detection and mitigation, and conclude with some of the research questions in this spectrum.


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PRICED REDUCED | 11270 Henness Road, Truckee
4 Bed | 3.5 Bath | 3194 sf
Offered at $1,569,000
An exquisite two-story modern mountain home stands on a quiet sunny plot in Grays Crossing. Over-sized windows throughout the house strategically frame the 5th hole of the Peter Jacobsen/Jim Hardy designed championship golf course. This beautiful 4 bedroom, 3.5 bath stunner is designed for an easy and relaxing lifestyle, with hardwood floors, an abundance of natural light, spectacular golf setting views, chef's kitchen, and a fabulous living area. There are 2 master suites on the main floor with 2 bedrooms upstairs and loft. A separate, sizable laundry/mudroom is perfectly situated off the over-sized 2-car garage.
Gray's Crossing is a community that is close to everything Lake Tahoe. You are sure to enjoy the beauty of this neighborhood, from the many hiking and bike trails, nearby slopes from Northstar to Squaw Valley, and historic downtown Truckee.
View Tour of 11270 Henness Road
Contact Team Blair Tahoe at 530.581.1400 or email us at firstname.lastname@example.com for more information on this fabulous property.


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Our pipeline strategy is to build a risk-controlled clinical-stage pipeline with an exclusive focus on novel or highly differentiated biologics. To achieve a delicate balance between exclusive positioning of highly innovative therapeutics and the related development risk, we have built a globally competitive biologics pipeline comprising a risk-controlled and "fast-to-market" China Portfolio and a transformational "fast-to-PoC (proof of concept)" Global Portfolio.
These two strategies and the resulting two portfolios complement each other. This enables us to achieve a balance among our ambition to develop novel or highly differentiated drugs, and our goal of efficiently advancing our pipeline assets towards commercialization while navigating the inherent development risks.
The fast-to-market China portfolio is built around in-licensed investigational drugs that have demonstrated a favorable clinical safety profile and preliminary efficacy data in phase 1 or 2 trials in the US, Europe, or elsewhere. I-Mab only selects candidates with the potential to become novel or highly differentiated therapeutics for urgent unmet medical needs in China. Then, through in-house R&D and drawing on I-Mab's deep knowledge and past experiences of the requirements for drug approval by the National Medical Products Administration (NMPA), the company builds additional data packages for late-stage clinical trials to support product registration. I-Mab's direct access to Chinese clinical trial networks, combined with its insights into the Chinese regulatory environment, guides investigational drugs through this complex terrain.
The China portfolio today comprises five investigational drugs that are either in, or ready to enter, clinical trials in Greater China.
I-Mab plans to rapidly advance the China portfolio to NDA approval, and expects all the clinical assets in the China portfolio to undergo Phase 2, 3, or registrational trials in 2020, with NDAs to the NMPA being filed in sequence between 2021 and 2024. I-Mab will initially partner with a specialty pharmaceutical company with commercial experience and infrastructure in China to jointly market these products.
TJ202 was originally developed by MorphoSys and showed favorable clinical safety and efficacy data from a clinical trial conducted in the European Union (EU). We own an exclusive license right to develop TJ202 in Greater China to address the current unmet needs and commercial opportunities in China for multiple myeloma and potentially autoimmune diseases, such as systemic lupus erythematosus (SLE). As shown in a Phase 1/2a study in adult patients with relapsed or refractory multiple myeloma (MM) in Austria and Germany, TJ202 is highly differentiated from the currently marketed CD38 antibody, with shorter infusion time (0.5–2 hours, compared with 3.5–6.5 hours) and lower infusion reaction rate (7% compared with 48%) under a similar pre-medication condition with dexamethasone, anti-pyretics and antihistamines. Unlike the currently marketed CD38 antibody, TJ202 does not down-regulate CD38 expression on the surface of bone marrow myeloma cells in vitro, maintaining sensitivity of myeloma cells to TJ202 for repeated treatments.
We have initiated a Phase 2 registrational trial as a third-line monotherapy, and a Phase 3 trial in combination with lenalidomide as a second-line therapy, both in patients with MM in Greater China. We aim to submit an NDA for TJ202 as a monotherapy in 2021, followed by another NDA submission for TJ202 as a combination therapy. An IND application for a trial in SLE is expected to be submitted in the fourth quarter of 2019.
Clinical Trials:
TJ202 Combined With Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
TJ202, Lenalidomide and Dexamethasone vs. Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
Originally developed by Genexine, TJ101 (INN: eftansomatropin) is a long-acting recombinant human growth hormone (rhGH) with a novel molecular format of the hyFc-fusion technology. We own the Greater China rights to develop TJ101 as a weekly treatment for pediatric growth hormone (rhGH) deficiency. TJ101 is superior to the existing daily injection of rhGH for convenience of usage and patient compliance, and has potentially better safety as a pegylated formulation.
Currently, only 3.7% of pediatric patients with growth hormone deficiency receive growth hormone therapies, mostly on daily regimen. The advantages of TJ101 have significant clinical relevance to address an important clinical need and to cover a significant market gap.
TJ101 has demonstrated safety and preliminary efficacy in three multi-regional clinical trials conducted by Genexine in Europe and Asia. In a previous Phase 2 trial conducted by Genexine, both weekly and bi-weekly administration of TJ101 demonstrated similar efficacy to daily injection of Genotropin, a short-acting rhGH. TJ101 has a good safety profile with no study drug-related serious adverse events, and its tolerability is consistent with known properties of marketed rhGH products. We expect to submit an IND for a Phase 3 registrational trial in China in 2020.
Clinical Trials:
A Clinical Study in AGHD to Assess Safety, Tolerability and Efficacy of GX-H9
Dose Finding Study of GX-H9 in Pediatric Patients With Growth Hormone Deficiency
In-licensed from Ferring, TJ301 (INN: olamkicept) is the only clinical-stage selective and highly differentiated interleukin-6 (IL-6) inhibitor, owing to its novel mechanism of action on the trans-signaling pathway. Compared with the approved antibody drugs that directly block IL-6 or IL-6 receptor, TJ301 is expected to provide a better safety profile for the treatment of IL-6-mediated inflammation without affecting some of the normal physiological functions of IL-6, such as acute immune response against infection and metabolic regulation.
TJ301 was well-tolerated in three clinical trials conducted in Germany involving 128 subjects, including two Phase 1 trials and one Phase 2a biomarker study (FUTURE study). No apparent dose-related AEs were observed. Promising treatment effects of TJ301 were observed in both ulcerative colitis (UC) and Crohn's disease patients in the FUTURE study.
TJ301 is expected to have applications in a broad spectrum of autoimmune disease indications. We have initiated a multi-regional Phase 2 clinical trial in Taiwan, South Korea, and China. We expect to obtain data from this Phase 2 clinical trial in 2020. After clinical efficacy and differentiation are validated for UC, we plan to develop TJ301 in other inflammation indications in which the pathogenic role of IL-6 is implicated.
Clinical Trials:
Safety and Efficacy of TJ301 IV in Participants With Active Ulcerative Colitis
Originally developed by MacroGenics, enoblituzumab is a humanized antibody directed at B7-H3, a member of the B7 family of T-cell checkpoint regulators. B7-H3 is widely expressed across multiple tumor types and plays a key role in the regulation of immune response against cancers. We recently acquired the development and commercial rights of enoblituzumab from MacroGenics for Greater China.
As the only conventional B7-H3 antibody in clinical development worldwide, enoblituzumab is the most advanced clinical-stage anti-cancer immunotherapy for a variety of solid tumors that overexpress B7-H3. In multiple clinical trials conducted by MacroGenics, enoblituzumab has shown a well-tolerated safety profile and preliminary clinical efficacy. It increased CD8 T-cell infiltration in tumors with more focused T-cell repertoires in patients treated with enoblituzumab as a monotherapy. A combination therapy with enoblituzumab and pembrolizumab correlates with preliminary efficacy signals in recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) and non-small cell lung cancer (NSCLC).
We plan to submit an IND for a Phase 2 or registrational trial in China if approved by the NMPA in patients with recurrent or metastatic SCCHN. Further clinical development is being planned together with MacroGenics to extend to other cancer indications in China and globally.
Clinical Trials:
Safety Study of Enoblituzumab (MGA271) in Combination With Pembrolizumab or MGA012 in Refractory Cancer
Neoadjuvant Enoblituzumab (MGA271) in Men With Localized Intermediate and High-Risk Prostate Cancer
Safety Study of Enoblituzumab (MGA271) in Combination With Ipilimumab in Refractory Cancer
Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors
TJ107 (INN: efineptakin) is the world's first and only long-acting recombinant human interleukin-7 (rhIL-7) known to boost cancer-fighting T lymphocytes by increasing their number and functions. We have acquired exclusive rights from Genexine to develop and commercialize TJ107 in Greater China. We have positioned TJ107 to address a huge unmet medical need in oncology. First, TJ107 can be an oncology-care agent to treat cancer treatment-related lymphopenia (low blood lymphocyte levels), a common condition that occurs in cancer patients who have received chemotherapy or radiation therapy, and for which there is no approved treatment. This condition causes further damage to patients' already compromised immune system and weakens its ability to fight cancers. Second, TJ107 has been shown to synergize with a PD-1 antibody in a tumor animal model potentially through increased T-lymphocyte activation and proliferation.
The clinical safety and effect of TJ107 on T cells have been investigated in multiple previous and ongoing clinical trials in South Korea and the United States. TJ107 was well-tolerated without serious adverse events, and TJ107 treatment resulted in a substantial increase in the number of CD4 and CD8 T cells, natural killer T cells, naive T cells, central memory, effector memory, and terminally differentiated effector memory T cells, without affecting the number of B cells, natural killer cells, monocytes or Tregs.
By leveraging the results of Genexine's ongoing clinical trials in South Korea and the United States in advanced solid tumors, we aim to rapidly advance the clinical development of TJ107 for approval in Greater China. We are conducting a Phase 1b trial in China to determine a suitable dose range for subsequent trials. We plan to submit a clinical trial application for a Phase 2 trial in cancer patients in 2020.
Clinical Trials:
Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TJ107 in Chinese Patients With Advanced Solid Tumors
Whereas the goal of the China portfolio is to bring in-licensed products to the Chinese market as quickly as possible, the global portfolio focuses on demonstrating proof of concept, safety, and preliminary efficacy of I-Mab's internally developed innovative biologic drug candidates. Our fast-to-PoC global approach is illustrated by our Global Portfolio, in which the strategy is to clinically validate these candidates under the US FDA's streamlined regulatory system for innovative drugs, and to use the validated clinical data to pursue further development in China.
Our Global Portfolio focuses on two molecular classes: monoclonal antibodies and bi-specific antibodies.
Monoclonal antibodies. Among the five monoclonal antibody drug candidates, TJM2, TJC4 and TJD5 are undergoing Phase 1 clinical trials in the US. TJ210 and TJX7 are at the CMC stage and are expected to be ready for IND submissions and subsequent Phase 1 clinical trials in 2020 in the US.
Our CD47 and CD73 antibodies are globally competitive and have huge potential to become the next generation of immuno-oncology agents. TJC4 and TJD5 in our Global Portfolio have attracted a high level of interest from global pharmaceutical companies and KOLs due to their clinical differentiation from competitor antibodies. This is a strong testament to our discovery capability in target biology, antibody engineering, translational medicine and antibody CMC.
Bi-specific antibody panel. Despite the recent success of checkpoint inhibitors, it is estimated that more than 60% of cancer patients do not respond to PD-1/PD-L1 monotherapies. In addition, some patients develop resistance after initial treatment with these therapies. As a result, the standard of care today leaves many cancer patients underserved. There is consensus among cancer immunologists that tumors that do not respond to PD-1/PD-L1 treatment have poor immunologic features, such as an absence or paucity of tumor-fighting immune cells, or the presence of dysfunctional immune cells within the tumors, collectively known as "cold tumors."
We believe that PD-1/PD-L1 non-responders can be better treated with novel bi-specific antibodies with a second targeting component attached to the anti-PD-L1 moiety. This elicits a sufficient immune response to convert a "cold tumor" to an immune-active "hot tumor." Such unique properties of our bi-specific antibodies cannot be substituted by a combination of the PD-L1 antibody with a selected second component (either cytokine or antibody) in a free form. The underlying mechanism is such that the second component must be structurally integrated with the tumor-engaging PD-L1 antibody in order to concentrate and function inside the tumor, which cannot be readily achieved by the two free agents used in combination.
We have successfully generated a panel of four bi-specific antibodies in which our proprietary PD-L1 antibody acts as the backbone (the first signal) and is linked with various second components (the second signal). These include a 4-1BB agonist antibody (TJ-L14B), an IL-7 cytokine (TJ-L1I7) a B7-H3 antibody (TJ-L1H3), and a CD47 antibody (TJ-L1C4), which work synergistically with the PD-L1 backbone in various assays and cancer animal models. This unique panel of bi-specific antibodies is only made possible by our proprietary and partnered antibody-engineering technologies and the availability of our proprietary monoclonal antibodies.
In addition, we have generated two other bi-specific antibodies that are tailor-made to function as novel 'fortified' antibodies by linking TJC4 with granulocyte-macrophage colony-stimulating factor (GM-CSF) for the treatment of solid tumors, or by linking one of our tumor-associated antigen antibodies with a 4-1BB antibody as a novel cancer treatment agent that only activates T cells after tumor engagement.
All bi-specific antibodies have been validated in a series of robust in vitro and in vivo studies for biological proof-of-concept, providing a solid basis for clinical validation in cancer patients.
We expect to advance the three monoclonal antibodies currently in US Phase 1 trials into Phase 2, and to initiate new US clinical trials for TJ210 and TJX7 and the first few bispecific antibodies by the end of 2020 or early 2021. As part of this effort, I-Mab is expanding its clinical team based in Maryland, US, and is also setting up a translational medicine group with a biomarker laboratory in the US.
TJM2 is an internally discovered neutralizing antibody against human granulocyte-macrophage colony stimulating factor (GM-CSF), an important cytokine that plays a critical role in chronic inflammation and destruction in autoimmune diseases such as rheumatoid arthritis (RA). GM-CSF can polarize macrophages into a pro-inflammatory M1 phenotype and is known to induce an inflammatory cascade involving other pro-inflammatory cytokines such as tumor-necrosis factor (TNF), interleukin-1 (IL-1), IL-6, IL-12, and IL-23. It is evident that GM-CSF plays a crucial role in the pathogenesis and disease progression of multiple autoimmune conditions.
TJM2 is a humanized IgG1 that displays high-affinity binding to GM-CSF and blocks its signaling and downstream effects. We initiated a first-in-human study in healthy volunteers in the US. We have enrolled and completed dosing of four planned cohorts, with each cohort consisting of eight subjects. Data from this clinical trial has facilitated IND submission in China in August 2019 for a multiple-dose Phase 1b study in patients with RA, before expanding to other autoimmune and inflammatory conditions in which GM-CSF is known as a pathogenic cytokine in disease activity and progression, and which have a high unmet medical need. TJM2 is expected to be the first antibody of its class to enter clinic trials in China in 2020. If approved, it is expected to provide an effective treatment option as a disease-modifying anti-rheumatic drug therapy. We also intend to investigate the efficacy of TJM2 in reducing or preventing cytokine release syndrome (CRS) and neurotoxicity associated with CAR-T therapy through collaborations.
Clinical Trials:
Study of TJ003234 (Anti-GM-CSF Monoclonal Antibody) in Healthy Adult Subjects
As a fully human monoclonal antibody targeting CD47, TJC4 is a prime example of I-Mab's in-house innovation. CD47 has emerged as one of the most promising immuno-oncology targets. Blockade of the CD47-SIRPα pathway involved in tumor progression represents one of the most effective tumor-killing mechanisms. However, the first wave of clinical-stage CD47 antibodies were found to bind to red blood cells (RBCs) and cause significant hematologic adverse effects, such as severe anemia.
TJC4 has the potential to stand out from other clinical-stage CD47 antibodies. Unlike competitor molecules, we developed TJC4 by design to uniquely minimize the binding to RBCs while retaining anti-tumor activities in line with other antibodies of the same class. This key differentiation is achieved through additional RBC counter-screening to select rare antibody clones that bind to CD47 with high affinity but do not bind to, or bind minimally, to RBCs. The differentiation of TJC4 has been extensively validated in a series of robust in vitro assays and primate studies. In a GLP toxicology study involving 40 monkeys, no hematologic side-effects were seen even with repeated injections of high doses of TJC4 (up to 100 mg/kg). This unique property may enable TJC4 to be used safely at higher doses to explore its treatment potential in cancers, differentiating it from other clinical-stage CD47 antibodies.
We are evaluating TJC4 in a Phase 1 clinical trial with cancer patients in the US. We have also obtained IND approval by NMPA and plan to begin a Phase 1 clinical trial of TJC4 in patients with hematologic malignancies in China.
Clinical Trials:
Study of TJ011133 Subjects With Relapsed/Refractory Advanced Solid Tumors and Lymphoma
TJD5 is an internally developed, humanized inhibitory antibody against human CD73. CD73 is expressed in tumors and is the rate-limiting enzyme that converts extracellular AMP to adenosine, a potent immunosuppressive molecule in the tumor micro-environment. TJD5 allosterically inhibits CD73 in a substrate non-competitive manner. This results in a decrease in adenosine production and an increase of T cell anti-tumor activity.
TJD5 is differentiated from clinical-stage antibodies of the same class by its novel epitope, which works through a unique intra-dimer binding mode, resulting in a complete inhibition of the enzymatic activity and avoiding the aberrant pharmacological property known as the "hook effect." TJD5 displays sub-nanomolar binding affinity to CD73. In vitro, TJD5 completely reverses adenosine monophosphate (AMP) or tumor-cell-mediated suppression of T cells in a concentration-dependent manner; in vivo, TJD5 combined with a PD-L1 antibody exhibits a superior or synergistic inhibitory effect on tumor growth.
We have initiated a Phase 1 clinical trial in the US in patients with advanced solid tumors in collaboration with TRACON Pharmaceuticals. Safety data on TJD5 is expected in 2020. In China, we plan to begin a clinical trial to evaluate the safety, tolerability, pharmacodynamics/pharmacokinetics, and potential efficacy primarily in patients with lung cancer.
Clinical Trials:
Study of TJ004309 in Combination With Atezolizumab (Tecentriq®) in Patients With Advanced or Metastatic Cancer
TJ210 is a fully human, high-affinity antibody directed against complement factor C5a receptor 1 (C5aR1) for the treatment of cancers and potentially autoimmune diseases. Tumors produce large amounts of C5a to attract C5aR1-expressing myeloid-derived suppressor cells (MDSCs), M2 macrophages and neutrophils. These myeloid cells critically contribute to an immunosuppressive microenvironment as part of the evading mechanism of tumors, and are associated with poor prognosis and resistance to PD-1/PD-L1 therapies in many cancers. Inhibition of C5a or its receptor in mice leads to markedly reduced MDSCs and has an inhibitory effect on tumor growth in various tumor-bearing animal models. TJ210 has been shown to have a synergistic anti-tumor effect when combined with PD-1 therapies in PD-1-resistant tumor models. TJ210 exerts strong anti-tumor activity by blocking the activation and migration of C5aR1-expressing myeloid cells.
TJ210 is highly differentiated as it binds to a novel epitope and possesses superior functional properties. Compared with a competitor antibody, TJ210 shows higher in vitro potency, especially when C5a concentrations are high. TJ210 binds to C5a receptors in both humans and monkeys, making preclinical safety assessment possible. In addition, TJ210 has therapeutic potential in multiple inflammatory and autoimmune indications in which the role of the C5a/C5aR axis has been implicated. We partnered with the original developer of TJ210, MorphoSys, for Greater China rights and shared global rights. TJ210 is progressing towards IND submission in the US in 2020.
TJX7 is an internally discovered, humanized neutralizing antibody targeting the CXCL13 chemokine. CXCL13, through its receptor CXCR5, plays a key role in forming germinal centers, which are critical for immune response. One of the key pathogenic features in autoimmune diseases is related to the aberrant formation of ectopic germinal centers formed in affected organs, contributing to chronic inflammation and tissue destruction. Elevated serum CXCL13 levels, CXCR5-expressing T cells and pathogenic germinal center B cells, and even ectopic germinal center formation are found in multiple autoimmune diseases, including Sjögren's syndrome, RA, multiple sclerosis, and SLE.
TJX7 is being developed for the treatment of autoimmune disorders and has been shown to bind to CXCL13 with sub-nanomolar affinity, effectively blocking the interaction between CXCL13 and CXCR5 and downstream signaling. TJX7 has been shown to completely inhibit the migration of primary human tonsil B cells. Pharmacodynamic studies in mice and cynomolgus monkeys have confirmed TJX7's inhibitory effects on germinal center formation and antibody production. Results generated so far indicate that TJX7 may provide a new therapeutic angle in the treatment of autoimmune diseases as it acts uniquely at the core of tissue pathologies. TJX7 is currently under CMC and preclinical development.
PD-L1-based bi-specific antibodies are designed according to the scientific rationale that a PD-L1 antibody, when engineered with a selected second immune component such as a cytokine or another antibody, is able to convert "cold tumors," which typically do not respond to PD-1/PD-L1 inhibitors, into "hot tumors," which are more sensitive to PD-1/PD-L1 therapies. Such PD-L1-based bi-specific antibodies are expected to increase the probability of treatment success in patients who do not respond to PD-1/PD-L1 treatment.
Based on this concept, we have generated a panel of bi-specific antibodies using our proprietary PD-L1 antibody sequence as the backbone (the first signal), linked to a second component (the second signal) of selected immune properties. The second signal for this panel of bi-specific antibodies includes IL-7 cytokine (expanding T effector cells), 4-1BB and B7-H3 antibodies (activating T cells synergistically with PD-L1), and CD47 antibody (adding the macrophage-killing mechanism). We strive to validate all bi-specific antibodies through a series of robust in vitro and in vivo studies for proof-of-concept, providing a solid basis for further development.
TJ-C4GM is a novel molecule composed of our CD47 antibody linked to an engineered GM-CSF moiety fused at the C-terminus of the antibody heavy chain, creating a "fortified" version of the CD47 antibody that is specifically designed for the treatment of solid tumors through the CD47-mediated macrophage-activating mechanism. The unique functional properties of TJ-C4GM have been confirmed in a series of in vitro and in vivo tumor animal models, in which TJ-C4GM showed superior anti-tumor activity than TJC4 or GM-CSF used either alone or in combination. TJ-C4GM is currently at the CMC and preclinical development stage.
TJ-CLDN4B is a bi-specific antibody targeting both a tumor-associated antigen and 4-1BB, a co-stimulatory molecule on T cells. In collaboration with ABL Bio, we developed TJ-CLDN4B with two key advantages over antibodies in clinical development. First, it is capable of binding to tumor cells even with low expression levels of tumor-associated antigen, making it more suitable for a broader patient population. Second, T cells are only activated after tumor cell engagement by TJ-CLDN4B, which avoids the liver toxicity associated with pan-activating 4-1BB antibodies in clinical studies. TJ-CLDN4B is currently at the CMC and preclinical development stage.


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Document Filing
After your company has been incorporated or organized in its domestic (home) state, you may encounter situations where another document is required to be filed to make changes to company details, to restore the company to active status, or to change the company status.
CorpCo offers document filing services for your existing company in any state in the US as well as the District of Columbia.
Foreign Qualification/Registration
Federal Employer Identification Number (EIN or Tax ID)


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Magento to Shopify Migrationby Beyond Eleven Fresh Money Making Ideas
Follow this complete guide in order to migrate your eCommerce store. Recommended Features
- magento
- shopify
- shop migration
- ecommerce
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Review on Magento to Shopify MigrationShopify is a SAAS platform as it is is an easy-to-use and customizable platform, so you dont have to think about your own hosting and security. The number of entrepreneurs who want to move their online store from the Magento platform to Shopify is constantly growing.
For example if you have thousands of products in your Magento store you need to move categories, subcategories and other features to Shopify thoroughly.
Related to Magento to Shopify Migration
Created on Apr 24th 2019 23:57. Viewed 487 times.
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Surgical stainless steal tweezer with diamond polished tip. These tweezers are the tweezers that actually work and is preferred by professionals for that wider grip.
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When needing to grip more than one eyebrow hairs at a time, this Tweezer is for you. Made in Pakistan of pure Stainless Steel, this quality Tweezer will get the job done.
Versatile tweezer can pull one hair or a few hairs. Use the pointed end to isolate one hair or the flat part to gather a group. Stainless Steel construction and is crafted in Pakistan.
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The City Vault would like to invite you to the advance movie screening of American Sniper on January 8th at 7:00 pm.
Tickets are FREE but expected to go quickly. You must have a ticket to attend this screening but a ticket does not guarantee seating–seating is first come, first served —GET THERE EARLY
U.S. Navy SEAL Chris Kyle (Bradley Cooper) takes his sole mission — protect his comrades — to heart and becomes one of the most lethal snipers in American history. His pinpoint accuracy not only saves countless lives but also makes him a prime target of insurgents. Despite grave danger and his struggle to be a good husband and father to his family back in the States, Kyle serves four tours of duty in Iraq. However, when he finally returns home, he finds that he cannot leave the war behind.
Release date: December 25, 2014 (USA)
Director: Clint Eastwood
Story by: Chris Kyle
Cast: Bradley Cooper
Music composed by: Ennio Morricone, Clint Eastwood
Production companies: Village Roadshow Pictures, Malpaso Productions


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Memphis a bankruptcy proceeding lawyer are usually always dedicated for clients to be able to grant these complete finest services. Just what they carry out? They use to take into account the bills, goals, limits etc regarding clients; they provides you the data on financial along with debt-relief options that exist for an individual. It lets you create significantly informed decisions linked to the economic future regarding yours. Does you can file for your insolvency with out a lawyer? Yes it really is, but it could be tough, when possible, to acquire via this kind of complex means of bankruptcy your own.
How are going to ensuring an individual?
They are a good idea to an individual by ensuring that you will be filing of all paperwork will be correct which is on moment or not necessarily. They are a good idea to an individual while figuring out that just what options are usually good for your requirements to enable you to take appropriate decisions depending on the situation inside the whole method. They is useful for helping you to own favorable settlement available for you. Their array of the training region constantly varies and in addition includes all from your probates as well as the estate planning around the a bankruptcy proceeding. They learn how to help their particular clients to have through the method with tiny stress along with confusion.
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And much more...
Esperance Center North residential programs offers on going opportunities to be part of the community, all personal appointments and shopping is done using community resources. Everyone has social and recreational opportunities on regular basis. The weekends are rich with a variety of activities. Residents attend theater productions put on by local theater companies and colleges. Bowling is a weekly event and a chance to meet up with friends from other community groups. Nearby festivals and fairs are a favorite, especially the "Big Hat Days" event during the Clovis Rodeo week. Special productions like Disney on Ice, Walking with the Dinosaurs and Ringling Brother's Circus are always a treat. On weekends of inclement weather, there are a variety of movie theaters to attend.
Day Program Activities:
"Every person has a program designed for their specific needs and behaviors"
Esperance North is close enough to take a trip to Shaver Lake, Yosemite or the Red Woods Park. There are times when a weekend trip, including a motel stay, is planned' possibly to the coast or San Francisco. Summer months provide the farmers market and Blue Grass music every Friday night in quaint and historic downtown Clovis. Should someone have a love for horses, Tally Ho Therapeutic Riding Academy is close by for guided riding lessons.
The residents of Esperance North are encouraged to take part in any activities and events that they are able to manage. All major holidays are celebrated in a "home like" manner to have everyone feel the specialness of the holiday.
If a resident has a religious preference, the service specific to that faith and holidays will be honored.
Hope with Expectation for Success
The Esperance Center North Day Program is community based and currently serves 13 consumers. We offer supported employment along with volunteer work. We have six people that have competitive wage jobs. The jobs are at local restaurants, and at The Clovis Pet Hospital where the person has a variety of tasks that help keep the pet hospital running.
Esperance North feels it is important to give back to the community in whatever way they can. Presently the consumers are volunteering twice a week at the 509 Veterans Post. They set up for events and wipe down tables and chairs. In the past they have washed police cars for the Clovis Police Department; they have done some basic maintenance chores at Fresno State University, and adopted a park to keep clean by picking up trash. The people in the program are always busy and function in a well structured environment. Public transportation training is one of the things that are worked on at different levels. Some can be at the point of learning how to board the bus, pay and sit appropriately, while others are looking for street or landmarks to know when to ring to get off. It is our goal that at some point the person can use the transit system functionally to become more independent.
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- Scorpio Gift Chocolate Truffles Assortment$40.00 – $115.00
- Mendocino Macho Dark Chocolate Truffle$3.00
- Peanut Butter Chocolate Truffle$3.00
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- Blueberry Chocolate Truffle$3.00
- Classic Chocolate Truffles Assortment$40.00 – $115.00
- Milk Chocolate Truffle Assortment$40.00 – $115.00
- Dark Chocolate Truffle Assortment$40.00 – $115.00
- White Chocolate Truffle Assortment$40.00 – $115.00
- Great Crate Gift Tower – Assorted Cookies, Fudge and Fudge Sauce$57.00
- Pacific Fire Chocolate Truffle$3.00
- Irish Cream Fudge$4.50 – $27.00
- Pina Colada Fun Pack – 4 piece$12.00
Northern California Chocolate Shops
Delicious artisanal chocolate and gifts handmade with care in our coastal candy kitchen in Mendocino County, California. We offer an array of gifts for every occasion at Mendocino Chocolate Company. Whether you're looking for a special present for a friend, or a treat for yourself, we have an amazing selection of fresh gourmet chocolate at our premier chocolate shops. Our locations are in the idyllic village of Mendocino, as well as the historic fishing and logging town of Fort Bragg. All of our signature truffles and originals, fudge and confections are handmade and decorated in small batches using the best premium ingredients and original recipes for exceptional quality and taste. To find the perfect gift, browse through our selection of chocolate gift boxes, novelty items, or holiday items – all made to bring that touch of coastal charm to your special recipient.
- Chocolate Bar$3.50
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- Chocolate Walnut Fudge in Dark Chocolate$18.00


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Sneferu was a boss. At least, he seems fairly admirable from a power and authority standpoint. I have no idea whether he was a benevolent ruler or not (although the Times article, "The Secrets of Snefru", indicates that he was thought of as the "Good King" compared to his son and successor, Khufu/the "Bad King"), but that doesn't seem to matter because he managed to compel his people to build at least three pyramids for him. Pharaoh Sneferu, first king of the 4th Dynasty, is best known (respective to pyramids) for ordering the construction of the Red Pyramid, the Bent Pyramid, and Maidum Pyramid in Dahshur. While these monuments are impressive feats of human labor and engineering what I think is more impressive is the great deal of authority the pharaohs had to compel their people of the importance of these public works.
In class we've discussed the importance of legitimate authority. Without it, there is no way Sneferu or any other Pharaoh could have gained so much power (the ability to get other people to do stuff for you). I think the magnitude of their power is so great not only because they have legitimate authority, that is, the ability to get people to do stuff for you because they want to (or think they want to) or see it as a rational choice. What helps tremendously is the different angles from which pharaohs draw legitimacy. According to Max Weber, there are three types of legitimate authority. (Weber, Economy and Society Vol 1)
The first is legal authority. This is the authority behind the institutions and bureaucracies that make complex states possible. The king's ability to govern by endorsing viziers and nomarches below him is part of the administrative hierarchy that provides legal authority. Citizens of Upper and Lower Egypt do not follow laws simply because the Pharaoh commanded they do something (at least not all of the time), but because it is a law and is therefore something they should follow because they are a citizen of that state. There are even rules which the Pharaoh must follow. Legal authority places power in impersonal institutions and laws rather than in the personal qualities of the Pharaoh himself. When one Pharaoh succeeds another, there is at least some continuity. The pharaoh in a sense draws his power from the legal authority of the state which he governs. Usually with legal authority, there is some sort of selection process that considers qualifications (like candidates running for an election, or an employee seeking a CEO position). So I will admit it does not align perfectly, but there are aspects that are consistent with government in Ancient Egypt.
But, we know that laws and bureaucracy, tradition and royal blood hardly cover the range of the pharaoh's legitimacy. The Egyptians didn't simply take cues from the pharaoh because he was in the position of power, they revered him because he had a great deal of charismatic authority. For the Ancient Egyptians, the pharaohs were Gods or at least as close as to being Gods as is possible for humans. Sneferu claimed he was the living sun god, Ra. This type of legitimacy is in some sense diametrically opposed to the institutionally permanent legal authority. Even so, pharaohs are holders of "specific gifts of the body and spirit; and these gifts have been believed to be supernatural, not accessible to everybody." (Weber) It is precisely because pharaohs are not chosen by the people, but by a higher power that gives them their charismatic authority. For this, their personalities are revered, not simply their office. Hence, great monuments and temples and sacrifices are made in their name. Consider the tomb of Hor-Aha alongside the tombs of many royal retainers. Lavish offerings are brought to the tombs to ensure their ka are well taken care of. Does part of this reverence come from fear? It undoubtedly does, which makes a pharaoh's authority a little less legitimate, but his coercive power is still power and speaks to the multitude of mechanisms by which pharaoh exerts power.
Another aspect of pharaoh's legitimate power is traditional authority. This is the type of authority that scholars might likely attribute to Ancient Egypt, but I really think all three of Weber's types of legitimate authority bear some presence. In the case of traditional authority, "obedience is not owed to enacted rulers, but to the person who occupies a position of authority by tradition or who has been chosen for such a position on a traditional basis." (Weber) At the level of kingship, Ancient Egypt was a patriarchy. So the decision of who would be the next pharaoh was not dictated by laws or even some sort of prophet discovery, but instead through family lineage. In this way, Ancient Egyptians owed their lives, belongings, labor, etc. to the pharaohs because they were of the royal line.


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You know, the bird and I were discussing the many different kinds of "moms" out there. There are "working" moms, "stay-at-home" moms, and the combination of the two, the "soccer moms".
Then there are the animal moms, I do not know what they call us. Weirdo tree-hugging lefty commie american hating elitist bastards, I think. Something like that. It has to become an acronym soon because I know it is pretty long. Even the acronym would be long.
But after watching last nights V.P. debate, and marveling at the seemingly deft, yet utterly obvious manner in which Governor Palin dodged questions, never giving a straight answer but going back to what she really wants to talk about, well, gave me no choice but to come up with a new kind of mom.
The Dodge Ball Mom.
And I bet a lot of us out there have them.


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Superstitions about New Born Children: Cats suck the breath of infants, and so kill them. This extremely unphilosophical notion of cats preferring exhausted to pure air, is frequently a cause of great annoyance to poor pussy, when, after having established herself close to baby, in a snug warm cradle, she finds herself ignominiously hustled out under suspicion of compassing the death of her quiet new acquaintance, who is not yet big enough to pull her tail. If you rock an empty cradle, you will rock a new baby into it. This is a superstition in viridi observatia, and it is quite curious to see the face of alarm with which a poor woman, with her tenth baby in her arms, will dash across a room to prevent the 'baby-but-one' from engaging in such a dangerous amusement as rocking the empty cradle.[152]
The swallow frigate was, in July 1812, engaged in a severe action with a French frigate near Majorca. One of the sailors, named Phelan, had his wife on board. In such circumstances, the woman is always expected to assist the surgeons in attending on the sick and wounded. The 2 ships being engaged yard-arm and yard-arm, the slaughter was great, and the cockpit became crowded with poor fellows in need of attention. While engaged in her service of kindness, the woman heard that her husband was wounded on deck. She rushed up, and reached the spot in time to catch poor Phelan in her arms. The kissed and embraced; but next instant a cannon-ball took off the unfortunate woman's head. The husband gave one agonized look at the dead wife, and then expired. When the rage of the battle was over, the 2 bodies were sewed up in a hammock and consigned to the deep. The hapless wife had, only 3 weeks before, given birth to an infant. The child was thus left an orphan, with no woman near it, and none but rough handed, though kind-hearted, tars to tend it. They all declared their willingness to be fathers to the little one; but a mother was still wanting. It happened, however, thatone of the officers had a female Maltese goat on board. The child was put to the goat, and followed his natural instinct by sucking. The animal became so accustomed to this proceeding, that she would lie down voluntarily to suckle the infant. Goat's milk is known to be very nourishing; and little Tommy (as the sailors called him) prospered with this substitute for a natural parent. [153]
Kicked Out of Heaven Vol. I
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The Untold History of The White Races cir. 700 – 1700 a.d.
525 pgs + 163 pix = 1,000s of FACTS!
Kicked Out Of Heaven Vol. I: The Untold History of The White Races; cir. 700-1700 a.d. is a 3 volume series that details everything about European society and mentality. In this edition you will find these facts: 100 pound hail stones, Sex in The Streets, Cuckolds in Poems Molly Houses, The Orders of Beggars, Torture, Medicinal Cannibalism, Food: Black Puddings & Eel Pie, Bathed Once a Year, Bloodthirsty Knights, Government Sanctioned Prostitution, Infants fed wine, Cross Dressing Men, Gang Raping Teenagers, Incest Marriages, Insane Kings & Queens, The Bastard Children, Condoms, Dildos, & Birth Control & A Long List of Infanticide. There's Many Many More Odd Facts Inside!
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Crescent ♍ Virgo
Moon phase on 11 July 2051 Tuesday is Waxing Crescent, 3 days young Moon is in Leo.Share this page: twitter facebook linkedin
Waxing Crescent is the lunar phase on . Seen from Earth, illuminated fraction of the Moon surface is 12% and growing larger. The 3 days young Moon is in ♌ Leo.
Wednesday Wed
Thursday Thu
Friday Fri
Saturday Sat
Sunday Sun
Monday Mon
Tuesday Tue
Previous main lunar phase is the New Moon before 3 days on 8 July 2051 at 04:09.
Moon rises in the morning and sets in the evening. It is visible toward the southwest in early evening.
Moon is passing first ∠0° of ♌ Leo tropical zodiac sector.
Lunar disc appears visually 4.5% narrower than solar disc. Moon and Sun apparent angular diameters are ∠1805" and ∠1887".
Next Full Moon is the Buck Moon of July 2051 after 12 days on 23 July 2051 at 16:36.
There is low ocean tide on this date. Sun and Moon gravitational forces are not aligned, but meet at big angle, so their combined tidal force is weak.
The Moon is 3 days young. Earth's natural satellite is moving from the beginning to the first part of current synodic month. This is lunation 637 of Meeus index or 1590 from Brown series.
Length of current 637 lunation is 29 days, 10 hours and 56 minutes. It is 2 hours and 32 minutes shorter than next lunation 638 length.
Length of current synodic month is 1 hour and 48 minutes shorter than the mean length of synodic month, but it is still 4 hours and 21 minutes longer, compared to 21st century shortest.
This New Moon true anomaly is ∠70.2°. At beginning of next synodic month true anomaly will be ∠104.1°. The length of upcoming synodic months will keep increasing since the true anomaly gets closer to the value of New Moon at point of apogee (∠180°).
8 days after point of perigee on 2 July 2051 at 20:59 in ♈ Aries. The lunar orbit is getting wider, while the Moon is moving outward the Earth. It will keep this direction for the next 4 days, until it get to the point of next apogee on 15 July 2051 at 16:49 in ♎ Libra.
Moon is 397 050 km (246 715 mi) away from Earth on this date. Moon moves farther next 4 days until apogee, when Earth-Moon distance will reach 404 065 km (251 074 mi).
8 days after its descending node on 2 July 2051 at 17:54 in ♈ Aries, the Moon is following the southern part of its orbit for the next 4 days, until it will cross the ecliptic from South to North in ascending node on 16 July 2051 at 09:35 in ♎ Libra.
22 days after beginning of current draconic month in ♏ Scorpio, the Moon is moving from the second to the final part of it.
5 days after previous North standstill on 6 July 2051 at 11:58 in ♊ Gemini, when Moon has reached northern declination of ∠19.198°. Next 9 days the lunar orbit moves southward to face South declination of ∠-19.133° in the next southern standstill on 20 July 2051 at 20:52 in ♐ Sagittarius.
After 12 days on 23 July 2051 at 16:36 in ♑ Capricorn, the Moon will be in Full Moon geocentric opposition with the Sun and this alignment forms next Sun-Earth-Moon syzygy.