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Robert Muchangi, a 28-year-old laborer from Meru County, Kenya, reportedly died on Wednesday at the Kenyatta National Hospital's intensive care unit, where he was admitted an attack in Meru.
Standard media reported that Muchangi, a bricklayer, was attacked in Kabuitu, last Wednesday, by a man suspected to have offered him a building job at his home. However after laborer visited the man to demand his dues, four-inch nails were driven into his head. Kaunga, the witness who rushed the victim to hospital after the attack, said Muchangi spoke to him about the assault before he lost consciousness.
The death of Muchangi comes with the added burden of a Sh300,000 medical bill for his family after his week-long stay in the hospital, where doctors managed to pull the four-inch nails out of his head.
An X-ray conducted after the nail removal, revealed that Muchangi's skull and brain were injured. Kitheo Sub-Location Assistant Chief Sabastian M'Iruri said they had launched a search for the suspects.
However the family of the deceased on Wednesday, questioned the silence of the police on the attack that has shocked many Kenyans. Police remained tight-lipped about the incident, with senior police officers in Meru declining to comment on the issue that has raised public concern. Mr Muchangi's sister, Regina Murugi, said the family was at a loss how to raise the money to pay the hospital bill and bury him.
"This is a difficult time for us. We are in mourning and cannot even afford the Sh4,000 for a postmortem that should be carried out as soon as possible," she said.
Ms Murugi appealed to the Government to assist the family to settle the bill and get justice for Muchangi by hunting down those responsible for the assault. The family described Muchangi as a peaceful person who left his village of Nguiri in Makengi location, Embu County, for Meru about 10 years ago to earn a living as a mason.


text:
Sixty per cent of those who bothered to cast a ballot last May likely woke up the morning after unable to believe Canada's new political reality. While the majority of Canadians now know the feeling of many Americans after the 2004 re-election of George W, the suggestion, "Do not mourn, organize!" seems simplistic. Indeed, preparing for 2014/15 requires first that progressives learn the lessons of 2011 -- and recognize what Mr. Harper's win means for Canada and Canadians.
One observation is that the political consciousness of Canadians appears to have changed drastically. Some readers may recall when the 1993 attack ad focusing on Chretien's face was firmly rebuffed in Canada. Less than 20 years later, our new majority government has embraced character assassination and the politics of personal destruction as a legitimate campaign strategy. They have pursued a mean-spirited public policy and attacked those who have the temerity to disagree with them.
Over the last five years, the Harper conservatives committed a series of crimes against the People's Parliament and dismissed the increasing concern expressed by noted constitutional scholars as so much noise. However, it was not only the traditional corporate mainstream media who formally endorsed these actions. By rewarding Conservatives with a majority, Canadians themselves have expressly and/or at least tacitly consented to this approach to politics and governance. What are we to make of these developments?
In the UK, a sketch comedy show called Little Britain pokes fun at those who inhabit "little England." This is a term historically associated with anti-colonialism, but is now applied to English people who are regarded as overly nationalistic and increasingly xenophobic. It's comedic potential is somewhat undercut however by the policies of the United Kingdom Independence Party (UKIP) and the rise of the English Defense League (EDL), both of whom profess to stand up for the rights of "ordinary" British and against foreigners generally, and the rise of Islam more specifically. The EDL is now claiming to be the protector of Britain and sending members into the streets to deter rioters. The extent to which the riots are being used as part of the UK's "multicultural malaise" bodes ill for a more in-depth understanding of the complexity of these multi-city events.
It may, unfortunately, be a sign of the times. Canada, once a middle power with noble ideals today seems smaller somehow and increasingly petty. The news that the PM locked himself in a bathroom during a recent trade mission to Brazil seems a perfect metaphor for a country once at home in the world, and now reduced to pouting in the potty when things don't go our way. While name calling is rarely useful, it may be cathartic in the short run to say what you see. To paraphrase that great philosopher Jeff Foxworthy, you might be a Small-Minded Canadian (SMC) if:
1. You think spending time being successful outside of Canada is a character flaw.
2. You think the threat of Quebec separatism was awful, but the Alberta "firewall" was A-OK.
3. Although you are the product of immigrants, you now want to close to the door to other more "ethnic" immigrants.
4. You think bilingualism is a plot to employ undeserving "frenchies."
5. You favour superstition over science, ideology over evidence, and ego over empathy.
So what do you think? Are we witnessing the closing of the Canadian mind? Can you improve on the list above? What about the Alberta tar sands, G20 protests, and prison instead of prevention?
If you feel so moved, please fill in the blank in the comments section below. Depending on the response, the results will be re-posted next week.
"If you (fill in the blank), you might be a Small-Minded Canadian."


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Catholic Health World shared the Cleveland Central Promise Neighborhood story. It came out this month in this cover story.
"Jerome Baker wanted to help his old neighborhood in Cleveland. He took part in a reading program for second-graders, serving in their school as an adult tutor.
At a community event months after he began, a little girl saw him from a distance and shouted, 'Hey, Mr. Baker.' It was all the encouragement he needed to continue.
'Her happy face and waves made me understand that, even in small ways, we are making an impact,' said Baker, 50. 'It's an awesome feeling.'"
The article goes on to detail the beginnings of Promise, its role in the neighborhood, and the difference the volunteers and others in the Promise Neighborhood are making. We encourage you to read the piece to remind or refresh you about the great work happening.


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The Source:
Dom Augustin Calmet [1672-1757] :
"Dissertation sur les Revenants en Corps, les Excommuniés, Les Oupirs ou Vampires, Brucolaques, etc." [1751]
Debure l'Aîné, Paris, 1751 - Volume II
This case, which does get a mention in Dom Calmet's book,
is said to have first appeared in a work by Charles Ferdinand de Schertz :
"Magia Posthuma", which (according to Dom Calmet) was published in
Olmutz in 1706. Thanks to Antoine Faivre, we can correct that. Apparently
the book was published in 1704 and the more precise title is: "Magia
posthuma per juridicum illud pro et contra suspenso nonnullibi judicio
investigata a Carolo Ferdinando de Schertz, arae salutiferae ubi paciscendum".
The Case:
I will quote Dom Calmet:
"He (de Schertz) reports ... about a shepherd from the village of Blow, close to the town of Kadam in Bohemia, who appeared several times (after his death) and who called at several persons, who all died within 8 days. The peasants of Blow disinterred the corpse of this shepherd and fixed it to the earth with a long stake that they had put through the corpse. That man, in that state, made fun of the people who treated him this way, and thanked them for providing him with a stick to keep away the dogs. That same night, he left his grave and frightened several people by his presence, and strangled them worse than he had done before. They called in the executioner, who put him on a wagon to transport him out of the village to be burned. This corpse cried out like a madman and moved his feet and hands as if alive; and when he was again pierced by stakes, he screamed out very loud and gave out very red blood in large quantities. Finally he was cremated, and this execution put an end to this spectre."
See Colin de Plancy's page in our Bits and Pieces section to read his version of this case.
The Date:
Sadly, no date is given, so all we can say is that the case
must have taken place somewhere before 1704. Having said that, new material
has come available to me in the shape of Heinrich Roch's "Neue Laußnitz- Böhm- und Schlesische Chronica" which was published in 1687. Here the date is given as 1337.
The Place:
So let us have a look at the location, which is given by Dom
Calmet as "the village of Blow, close to the town of Kadam in Bohemia".
Montague Summers calls it "the village of Blau, near the town of Kodon".
Kadam, Kodon or Kaaden is now called Kadan and can be found some 60, 70
kilometres to the North of the beer town Plzen (or Pilsen). Here is a link to Kadan: http://www.kadan.cz/
It looks like we will need more detailed (and possibly older) maps if we hope to find the village of Blow or Blau. Jan Perkowski (see under "possible follow-up") claims that the German name for Blow is "Flahe".
Personal Comments:
This does sound like a most unlikely story, with the corpse
pulling out the stake and making cynical remarks and all. It does not
necessarily mean that this story is not based on real happenings, but these
embellishments do suggest that the actual happenings may have taken place
quite some time before.
Possible Follow-Up:
Find as many versions of this story as you can. It has been in almost any book about vampires. Then try to go back to the original story, as far as you can. I have got as far back as 1687. See if you can take it any further. And there is also the location of Blau, Blow, Flahe or whatever. I am pretty sure that somewhere I must have a copy of an old colored map with Flahe on it. Or is it my memory that is trying to deceive me ?
© 2012 by Rob Brautigam - NL - Last changed January 2012


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Volker Hartkopf, Professor of Architecture; Director, Center for Building Performance and Diagnostics, Carnegie Mellon University Discussion Topic: Smart Building, Smart Campus, Smart City
Benjamin Levine, Interim Director MetroLab Initiative, Carnegie Mellon University Discussion Topic: Networks of Cities as Metro Labs for the (Data Intensive) Smart City Movement
Vivian Loftness, Professor and former Head of the School of Architecture, Carnegie Mellon University Discussion Topic: The Triple Bottom Line & Leveraging Federal Funding Resources to get there
Bertrand Lasternas, Senior Researcher, Carnegie Mellon University Discussion Topics: Two Recent Projects - (i) The Greenbutton/Portfolio Manager (ii) Metro21 & Traffic21
Mohammed Shahidehpour, Bodine Chair Professor of Electrical and Computer Engineering, Director of the Robert W. Galvin Center for Electricity Innovation, Illinois Institute of Technology Discussion Topic: IIT's Smart Microgrid, Research Laboratories and Technology Park - Creating a Hub for Economic Development and Innovation
Grant Ervin, Chief Resilience Officer, City of Pittsburgh Discussion Topic:The City of Pittsburgh's vision for Innovation, Sustainability and Performance
Dave Roberts is the Fellow for Smart Cities/High Penetration Renewable Energy at OSIsoft.
Since 1972, Professor Hartkopf has been teaching and conducting research at Carnegie Mellon University. His work covers a broad range of activities: international initiatives, funded research and professional consulting on building systems integration, advanced technology, building performance, energy conservation, urban revitalization, third-world housing and disaster prevention.
Currently, Prof. Hartkopf is leading the Building as Power Plant (BAPP) project. The BAPP has been selected by the US Congress as the National Test-bed for Advanced Technology in Building. The project will be realized on the Carnegie Mellon Campus. The BAPP will integrate advanced energy-effective building technologies with innovative energy generation systems, such that all of the buildings energy needs for heating, cooling, ventilating and lighting, as well as equipment are met on-site, maximizing the use of renewable energies. Broader implementation of its concepts in industry and government here and abroad are expected.
MetroLab Network is a newly launched network of more than 22 city and 28 university partnerships committed to strong regional partnership and cross-regional collaboration. The Network is focused on "smart cities"— particularly solutions to improve infrastructure, city services, and other public sector priorities.
The Network was launched as part of the White House's Smart Cities Initiative. Our founding members have memorialized their commitment in a letter to President Obama. Carnegie Mellon University and the City of Pittsburgh have been tapped to lead a new national alliance to research, develop and deploy innovative technologies to address critical challenges facing urban areas.
The Network's mission is to bring together university researchers with city decision-makers to research, develop, and deploy "RD&D" technologically‐ and analytically‐based solutions to improve our infrastructure, services, and other public sector priorities.
Vivian Loftness, FAIA, LEED Fellow, is University Professor, Paul Mellon Chair of Architecture and served a decade as Head of the School of Architecture at Carnegie Mellon University. With over 30 years of industry and government funding, she is a key member of Carnegie Mellon's leadership in sustainability research and education, the author of eight book chapters and editor of the recent Springer Reference Encyclopedia Sustainable Built Environments. She has served on the Board of Directors for the National Academy of Science's Buildings and Infrastructure Committee, the USGBC, AIACOTE, Phipps Conservatory, and AtSite Inc. In 2013, Vivian was recognized as a LEED Fellow, Senior Fellow of the Design Futures Council, and one of 13 Stars of Building Science by the Building Research Establishment in the UK. In 2014 and 2015, she was honored as a Hanley Award nominee for Vision and Leadership in Sustainability and received the Award of Distinction from AIA Pennsylvania. Vivian Loftness has a Bachelors of Science and a Masters of Architecture from MIT.
Bertrand Lasternas holds a graduate degree in Mechanical Engineering and is a Senior Researcher in the Robert L. Preger Intelligent Workplace Laboratory, Carnegie Mellon University (CMU). Lasternas is a key investigator on the CBEI project. His efforts are central to the Intelligent Workplace and the Center for Building Performance research and academic agendas, supporting the creation of a platform that integrates energy consumption data, indoor environmental quality data, weather data, and mechanical systems control choices into high performance building solutions of significance in the US and beyond.
Dr. Mohammad Shahidehpour is the Bodine Chair Professor in the Electrical and Computer Engineering Department, and Director of the Robert W. Galvin Center for Electricity Innovation at IIT. He is also the Principal Investigator of over $60 million grants on smart grid research and development. His DOE Project on Perfect Power Systems has converted the entire IIT Campus to an islanded microgrid. He has recently initiated CSMART (Center for Smart Grid Applications, Research, and Technology) at IIT for promoting the smart grid cybersecurity research and implementation and enhancing the resilience of wireless networked communication and control systems in smart cities. He is the 2009 recipient of the honorary doctorate from the Polytechnic University of Bucharest. He is currently a Research Professor at King Abdulaziz University (Saudi Arabia), Sharif University of Technology (Iran), as well as several universities in China including Tsinghua University, Xian Jiaotong University, Nanjing University, North China Electric Power University, and Hunan University. He was the recipient of the IEEE Burke Hayes Award for his research on hydrokinetics, the Edison Electric Institute's Power Engineering Educator Award, the Innovation Award from the Association of Electrical Engineering Department Heads, and the IEEE/PES Outstanding Power Engineering Educator Award in 2012. He has co-authored 6 books and 450 papers on electric power system operation and planning, and served as the founding Editor-in-Chief of the IEEE Transactions on Smart Grid. Dr. Shahidehpour was a member of the United Nations Commission on Microgrid Studies. His SPIKE initiative, which is established in conjunction with the Stuart School of Business at IIT, is facilitating the design and the implementation of affordable microgrids in impoverished nations. He is a member of the US National Academy of Engineering.
Grant Ervin serves as the Chief Resilience Officer for the City of Pittsburgh were he oversees the integration of sustainability and resilience into City services, programs and policy. Prior to joining the City of Pittsburgh, Grant served as the Regional Director for 10,000 Friends of Pennsylvania, a statewide smart growth and sustainable development policy organization; and as Public Policy Manager for Pittsburgh Community Reinvestment Group (PCRG).
Grant brings fifteen years of experience, intersecting the worlds of environmental, community & economic development and infrastructure policy to create innovative and sustainable solutions for local governments, community development organizations and state agencies.Grant has helped lead the development of a variety of innovative programs including Pittsburgh's inclusion in the Rockefeller Foundation's 100 Resilient Cities Initiative; the creation of the Uptown Eco-Innovation District, District Energy Pittsburgh, Pittsburgh and Neighborhood Community Information System and the Pennsylvania Community Transportation Initiative.


text: The Many Benefits of Industrial Recycling Programs 12/06/2018 | By Janelle Penny What happens to your recyclables after they leave your facility? Depending on what you're throwing out, your trash may be turned into toilet paper, cardboard shipping boxes, insulation and more. BUILDINGS toured the Marion, Iowa location of Quincy, Illinois-headquartered Quincy Recycle with Alan Schumacher, business development and sales for Quincy and president of the Iowa Recycling Association, to see how industrial recycling turns waste into reusable material. Reasons to Recycle There are many reasons to set up an organized industrial recycling program or beef up your existing one, Schumacher says. Aside from the obvious boost to your green credibility, recycling building materials and office refuse can: Help you earn credits toward a building certification Reduce your landfill fees Earn a profit from selling your processed recycled material "I like to say we're hunters and gatherers of like material," Schumacher explains. "We take the material that a lot of people throw their hands up about and say 'I don't know what to do with it' and try to find them resources. We try to focus on finding the best solution for each vendor's need and try to provide them with a return if at all possible." Where Your Industrial Recycling Goes You can ship industrial recycling material to your recycling partner in a number of ways, Schumacher says. Your waste hauler might gather your material in a compactor or pack it into 4-foot by 4-foot gaylord boxes. "There's still value in doing what we're doing, and in the long term we should not ever quit recycling because it's the right thing to do." - Alan Schumacher Paper products might be baled together or delivered loose to the recycler. Then the recycler will process your recyclables and sell the resulting raw materials to a business partner, who will turn them into new products. "Sorted office paper, a really good white grade, we'll send to a mill and they'll make toilet paper, tissue and paper towels out of it," says Schumacher. "We gather a lot of No. 8 and No. 9 newspaper and forward that to insulators who shred it, add cellulose and fire retardant back to it, and sell it to retailers. We do a lot of cardboard here that becomes new corrugate. We also have markets for PET plastic, HDPE plastics, LDPE shrink film and other plastics," he continues. Improve Your Industrial Recycling Program Ready to take your recycling practices to the next level? Start by assessing your current practices and the different waste products your facility generates. Schumacher suggests asking yourself these four questions: 1. What are your pain points? Is something missing in your current recycling program? Do you need to gain more value from the materials you're returning, or is it more of a service issue with your current provider? 2. How much waste material do you generate? Project the volume of your various waste materials to help your recycler determine how best to serve you, Schumacher says. "What are you getting for your materials now? Why are you baling or not baling? How are you measuring this? Are you getting paid for your material?" asks Schumacher. "I want to know by volume and grade of material what they're doing now so I can see if the account has value not only for Quincy Recycle, but for themselves to enhance what they're doing. Can I make a difference? Can I make a change in what they're doing, either in value or process?" he states. 3. How urgent is your need? Work with your recycler to develop a timeframe for them to do a site visit. The recycler will examine your waste and recycling processes on-site and review your disposal and profit options. "I still like to do the good old-fashioned dumpster dive. We look at what's going on and ask how many times a month does this load get pulled to the landfill, what's your pull charge, what's your compactor rental and what's your landfill charge," explains Schumacher. [More on sustainability: Zero Waste Tips for Event Venues] "If we feel that you have 40-percent volume of good material in that compactor and it's 10,000 pounds a month going to the landfill, then that's 4,000 pounds that you could be keeping out of the landfill, which would almost reduce your pull charges and landfill expense by 40 percent," he says. 4. How often will you need to dispose of material? You may have some one-time recycling jobs, like a PVC roofing membrane that you're replacing during a reroofing project. Good recyclers will still recycle it for you, but there may be an extra cost associated with the small load, Schumacher explains. (Pictured: Alan Schumacher, business development and sales for Quincy and president of the Iowa Recycling Association) "The charge might be because they have 10,000 pounds of material, but a mill typically has 40,000 pounds and the freight involved with it costs three times as much if you don't have a full load. It may cost a little more, but we can still keep it out of the landfill." [On topic: Plastic Stays Out of Ocean With Second Life] Financial profits associated with recycling are lower now that China no longer accepts recycling commodities from the U.S., Schumacher notes. However, the other benefits of repurposing usable material are undeniable. Architectural Salvage: Benefits of Reusing Old Buildings Showing off your use of reclaimed materials is more than a contribution toward your green building certification – it's a statement that your organization cares about the environment. Read on... "There's still value in doing what we're doing, and in the long term we should not ever quit recycling because it's the right thing to do," Schumacher explains. "Change is coming. People are starting recycling processes domestically. I'm seeing it now where people are opening businesses to start recycling plastic materials here in the Midwest vs. exporting it. It's coming. Stay tuned." Two handpicked articles to read next: Recycling Steel Can Contribute to LEED v4 Projects Fluorescent Lamp Disposal: Box and Store vs. Bulb Crushing Your browser does not support the audio element. Download Podcast About the Author Janelle Penny Editor-in-Chief at BUILDINGS Janelle Penny has more than a decade of experience in journalism, with a special emphasis on covering facilities management. She aims to deliver practical, actionable content for facilities professionals. Read more articles from this author > Previous ArticleMake Sure Your Solar Power Purchase Agreement Is ProfitableNext Article Read more on Sustainability / Resilience » Twitter Facebook LinkedIn Email Share Share Other Open Social Related Coverage Join Major Cities & Companies to Tackle the Climate Emergency Materials Science: The Demand for Sustainable Materials Facility Condition Assessment: Equipment Inventory Form Related Articles Sustainability / Resilience Why 'Justice' Matters to Facility Managers Sustainability / Resilience Giving Building and Design Materials a Second Life Sustainability / Resilience 5 Tips for Optimal Window Performance Sustainability / Resilience Minimizing the Radius of Distraction: A Guide to Speech Privacy Concerns & Sound Masking Systems Go get our newsletter! Join our Buildings Bulletin community now! 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Pace Honing Practices
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Head Coach
Join Date: Apr 2008
Posts: 2,305
Pace Honing Practices
Wed May 18 2400yds at Bard College
My focus this day was IM training. I won't swim any IM races at my next meet, Canadian Masters Nationals next week in Montreal, but I've come to enjoy IM training more than anything. Also I'll swim 200 BK and 100-200 FL next week so IM training helps cover those.
For my practice, I did three rounds of 50-100-150-200-150-100-50.
Round 1
I did the first half of each repeat BK and 2nd half FR (i.e. 50 was 25BK25FR, 200 was 100BK100FR). I held 14 SPL for both strokes throughout. My goal on this set was to increase pace on each successive swim. An exacting challenge as repeat distance increased to 200, but easier as repeats got shorter again. I succeeded in
SPL and
Round 2
I did 25FL 25BK throughout (so 200 was 25FL25BK25FL25BK, etc.) My goal here was to
both SPL (8 for Fly, 14 for BK) and pace. I see this set as good preparation for the 100 Fly + 100 Back that starts a 400 IM. My challenge in that is to maintain pace and efficiency for the entire 100 Fly and still feel relatively fresh as I begin the 100 Back. Alternating 25 Fly and 25 Back on the 200 in this set gives me a better chance of holding efficiency and pace, than if I swam 100 Fly followed by 100 Back. It also allows me more opportunities to practice the transition from Fly to Back.
Round 3
I did first half of each repeat BK and 2nd half BR. (i.e. 50 was 25BK25BR, 200 was 100BK100BR)
What I aimed to do was keep SPL constant (14 for BK and 7 for BR) while increasing pace on each successive repeat. As in the 1st set I was successful.
Thurs May 19 3000 yds at SUNY-NP
In this practicem my focus was 800-1500 FR which I'll swim next week in Montreal. In particular I was focused on impeccable pacing.
Set #1
I repeated BK-FR first set from Wed as my warmup, but this time alternated 25BK25FR
Set #2
3 rounds of 3 x 200 FR. First round on 3:20, 2nd round on 3:15, 3rd round on 3:10. 50 EZ BK between rounds.
On each round I held SPL at 14 for 1st 100 and 15 on 2nd 100, aiming to even or negative split each 200. (I bought a waterproof personal digital pace clock at Nationals, put it on the bottom in my lane and could see my splits each 50 as I turned.)
Round 1 2:48-2:45-2:42
Round 2 2:45-2:42-2:40
Round 3 2:42-2:39-2:37 (I went up to 16 SPL on last 200.)
Then EZ 50 BK and I went another 200 to see if I could swim faster. I worked harder but only went 2:37 again, taking too many strokes. So I did another easy 50 and repeated it. This time I controlled my stroke count, felt better and swam 2:35.
This set may be a bit much for any Forum members, but you don't need to repeat it exactly, but instead try to apply the key principles.
Task and challenge yourself to:
1) Maintain SPL
2) Be able to calibrate SPL and choose to
add one stroke per lap. By strategically I mean, when you add a stroke, you improve your pace. To even split or even negative split.
3) To swim multiple rounds of the same core set (i.e. 3 x 200) and improve your performance in each succeeding round.
4) If possible to be able to do that without increasing your stroke count.
I should emphasize I've been swimming sets like this for years and it's taken me years to be able to succeed at exacting tasks like this. But doing them forces such an intense degree of concentration that it puts me in a massively satisfying flow state. But they also give me a level of self-awareness and pacing control that's utterly invaluable in racing longer events like next week's 800 and 1500.
Here's two versions of a single main set to begin developing these SPL and pacing skills. I'll assume an SPL range of 15-16-17-18. Substitute whatever stroke count is appropriate.
Version 1
5 rounds of 3 x 100
Round 1 @ 15 SPL (1st 25 should always be one stroke less)
Round 2 @ 16 SPL
Round 3 @ 17 SPL
Round 4 @ 18 SPL
Round 5 @ 15+16+17+18 SPL (each 100)
Version 2
3 rounds of 5 x 100
Each round is
First time you try these, your goal is only to hit your intended counts. After you're able to do that with consistency, your goal is to swim faster each time you increase SPL. And not just to swim faster, but do so
without trying
. Simply adjust your count and stroke timing and
see your time get effortlessly faster
when you touch the wall.
Terry Laughlin
Head Coach & Chief Executive Optimist
May your laps be as happy as mine.
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Now, we've all seen these listicles about the very bestest GoT characters – and they're all pretty much the same. They include the pretty people, the most loveable, and the ones who get the most screen time. This one is a little different. Yes, you'll see a couple of the expected names on here, but this is a roundup of the most complex characters – whether it's because of the fabulous brain of Mr. Martin or the fabulous screen writing and acting. Yes, we know there's a lot of purists out there who believe you're not a true GoT fan if you a) haven't read the books and b) enjoy the TV show. There's also an awful lot of people who adore the show and have never attempted to read the books. We love both in their own right. The books are outstanding – incredibly powerful, complex, convoluted and mind-twisting. The TV show? It's probably the very first actually watchable and enjoyable TV fantasy adaptation – and they've done a pretty remarkable job of capturing Martin's creation. So, here's who we think makes the most brilliant characters list.
12. Ygritte
Ygritte makes our list because she's just so darn fierce. In a world that's pretty much dominated by men, with a few notable exceptions in the powerful houses, Ygritte is a breath of fresh air. She has no notion of politics or subtlety. She says what she means. This hard-on-the-outside wildling girl fights like a hell beast, isn't afraid to kill anyone who gets in her way, yet has a soft spot for Jon that even his betrayal doesn't completely quell.
11. Osha
Osha didn't have a huge amount of screen time, and she's a really minor character in the books, but she still makes our list of brilliant characters. It helps that she's played by Natalia Tena, best known as Tonks from Harry Potter. Suddenly, Natalia brought Osha to life as an undeniably complex and lovable character. This tough girl starts off as a captive wildling, then find herself the protector of both Bran and Rickon, defending them, and therefore the North, helping them flee Winterfell when it falls to Theon. Ironically, apart from Bran, Rickon and Hodor, the rest of the North automatically want her dead because of her heritage as one of the Free Folk. Racial prejudice at its finest. We were sad to see her die at the hands of the damned Bolton Bastard.
10. Sam
Sam isn't terribly complex – but his character has come a long way since we first saw him as a snivelling, pampered lordling arriving at Castle Black. In fact, in spite of what his seriously unpleasant father thinks, Samwell Tarly has flourished at The Wall. We've seen him step up, even when the self-confessed coward wanted nothing more than to run away. He saved Gilly and baby Sam and killed a White Walker in the process. He's not outwardly fierce, but he's fiercely loyal – and there's a solid backbone buried in there. Yes, he and Gilly provide some comedy and a their relationship is an oddly sweet one in such a brutal world, but his inherent goodness, his kindness, and his willingness to do what needs to be done, no matter how afraid he is, puts him on our list.
9. Bronn
Now, Bronn isn't exactly a mystery. He's fairly straightforward. He's a sell-sword – an unapologetic mercenary. He wants a good fight, lots of money, and plenty of fucking. Even after he's knighted, he's still feral, with a foul mouth and a bad temper. Another character that has taken quite a turn away from the books, where he was simply a blackhearted mercenary in Tyrion's employ. But Jerome Flynn makes him wickedly funny and irresistibly charming. There's just something about him. Although he took a tumble in our estimation when he essentially sold out Tyrion.
8. Cersei
She is cheating on her husband with her own brother, and all of her surviving children are the product of that incest. She is scheming and manipulative and is largely responsible for the misfortune that befalls the Starks. She wishes her younger brother dead, is happy when her husband dies, and supports her psychotic eldest son in his truly awful rule. And, when it's Tommen's turn to sit on the Iron Throne, she has his wife imprisoned by the High Sparrow. So why is she on the list? Because, thanks to brilliantly clever writing and undeniably good acting, there are moments when we feel for the apparently icy queen/queen mother. There's times when her visage cracks and we see her vulnerability. That's why she's on our list. She's one of those characters that fucks with your mind. She's a brutal, unforgiving bitch, and you hate her. You want her to freaking die. Then, out of absolutely nowhere, you feel an undeniable wave of compassion for her.
7. The Hound
The Hound. He's awesome. Sanndor Clegane is possibly one of Game of Thrones' saddest characters. As a child, he was dealt a terrible hand with The Mountain for a brother. He's a real product of his upbringing – crass, vile, and a total hardass. He fights like a demon, drinks a lot, is terrified of fire, and is pretty much permanently angry. And, in spite of everything he's done and everyone he's killed, there's something good that we get to glimpse from time to time, lurking inside. Yes, at first he kidnaps Arya and wants to ransom her – but he continues to protect her and teach her how to fight and to survive, long after there's nothing in it for him. And we cannot forget his dry, cutting humor that makes you laugh out loud.
6. Arya
Arya was a fairly simple child, but she's grown more complex as her tragic character has evolved. You undoubtedly feel for this little tomboy. She's witnessed the decimation and brutal slaying of her family and her house. From her father getting beheaded to the aftermath of the Red Wedding, poor Arya has seen far too much for one so young. Instead of cracking, she grows ever harder, even leaving poor Clegane to die in agony. The Punisher of Westeros and her hit list, quickly losing all regard for the value of the lives of others. All she wants is revenge – except in a few rare moments. And that compassion – when she can't kill Lady Crane – almost costs her her life.
5. Jaime
Jaime is an interesting character – on the surface, the typical Lannister – ruthless, cunning, spoiled. And he killed the king he was sworn to protect – not that you can blame him – the guy was insane. But he loves his family – and actually, he's an honourable man – look at his unlikely friendship with Brienne and his keeping the oath he swore to Catelyn Stark. His admission that he'd do anything for his sister, no matter what, in season 6, tells us essentially why he's committed so many atrocities – like his attempt to kill Bran – he did it to protect Cersei. But he wants to be a good man. And he loves his brother, in spite of everything.
4. Varys
The Spider and his little birds. We still don't really know his motivations. He participated in the plot to kill Daenerys but also ensured it didn't come to fruition. He says he just wants peace and what's best for the Seven Kingdoms. But we just don't know – we don't know enough about his past and his real self. What we do know is that he was a friend (sort of) to Ned Stark, and he remains a firm friend and ally to Tyrion (we think). Plus he's insanely clever and witty, and he and Tyrion make a fabulous double act.
3. Brienne
Another sad character. We think she's fab. She really is an outcast – a huge warrior, but a woman, having to prove herself repeatedly in man's world. The subject of much ridicule, poor Brienne seems to find and bond with other misfits – Pod, Jaime, Renly, Catelyn. She's a serious woman, but she's fiercely loyal and her honor is unmatched. And, we love her special friendship with Jaime – she brings out the very best in him without even trying.
2. Tyrion
Tyrion – another outcast with a truly tragic history. Deformed and ugly, Tyrion Lannister is the shame of his house – yet he's insanely intelligent. He's also cunning, ruthless, and so brave. He's got a way with words, too. He convinces the forces of King's Landing to defend the city when it looks like Stannis has won. The Imp is wickedly funny, and he loves fucking and drinking, but there's an awful lot more to him than that. He's fascinating – possibly the show's saddest character – he's been betrayed by everyone – his lover and his family – but there's something good in him – he always tries to do the right thing. Any scene with Tyrion in it is bound to be brilliant.
1. Olenna Tyrell
Yes, it's a surprise, but Olenna Tyrell, also known as the Queen of Thorns, tops our list. Dianna Rigg does an amazing job with Grandma Tyrell. IN spite of her great age and her idiot of a son, she holds her house together. Her biting remarks are hilarious, and the wrathful relationship between her and Cersei keeps you glued to the screen. In spite of her long life as the matriarch of House Tyrell, she doesn't take any bullshit – and she doesn't give it, either. She won't play the game in the same way as the rest of the court – she's a startling contrast to her manipulative granddaughter – and she's unpredictably awesome. May she live forever!
Edit: Yes, I know, she did not live forever!


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New Owners!
Diana and Trent Simpson
The End of an Era
After over ten years of ownership, we've decided to step down.
We'd like to thank you for this past decade of community. It has been a great ride.
Don't worry, this isn't the end of great Scottish gifts and apparel in Manitoba!
Hint of Heather and the Manitoba Tartan Company will now be operated by
Diana and Trent Simpson.
They can be reached at firstname.lastname@example.com or at (431) -337-1715
Thanks from all three of us!


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Show Notes
Thursday, Oct 19th 2017
8:20am: Co-Chairs of the 150 Leading Canadians for Mental Health Campaign, Jim and Sandi Treliving join us with Difference Maker David Grenier to share how some special Canadians are overcoming mental illness.
8:40am: Getting up close & personal with a kestrel & a barn owl with the Orphaned Wildlife Rehabilitation Society, plus your chance to win tickets to their gala this weekend.
Tuesday, Oct 17th 2017
7:10am WE Day Co-Founder Craig Kielburger shares how 20,000 BC students are about to celebrate the youth movement to tackle global and local social issues.
8:20am "How can we fix hockey's concussion problem with one simple step? Canadiens' legend Ken Dryden and author of the new book "Game Change" shares the answer at 8:20 on BT Tuesday."
8:40am Halloween & Fall Décor on a Dime: Halloween and fall trends you can do up for the season, yourself! How to give your summer lantern a spooky makeover, and get the trendy rope bowl, for WAY less, when you do it yourself!
Monday, Oct 16th 2017
6:40, 7:40, 8:10am: Can TJ keep up with the ladies at the Oakridge Seniors Centre? How line dancing keeps them fit and sharp.
8:20am We chat with Murdoch Mysteries' Yannick Bisson and Helene Joy!
8:40am Perfect For Your Next Party – Authentic Mexican Dips! They are perfect for your next party or get together. Learn how to make these authentic Mexican dips when Chef Rossana Ascencio joins us in the BT kitchen!
Friday, Oct 13th 2017
6:50am/8:10am: Sliding down the pole is not as easy as it looks! Tara Jean heads inside the Burke Mountain Fire Station in Coquitlam.
7:40am Thor's Hammers: Jackie Chan gets dramatic in the political action thriller 'The Foreigner' plus Thor drops the Hammers on the new horror flick 'Happy Death Day'.
8:20am We introduce you to Andrew Teel, an inspiring Vancouver teen who is making a difference and giving back to the community.
8:40am Tips & Tricks for Preparing Fish With Chef Ned Bell: Ned Bell, Ocean Wise Executive Chef, joins us to share his tips on fish prep and his Arctic Char with parsnips and lentils recipe from his new cook book Lure.
Thursday, Oct 12th 2017
7:40am Revelations about Harvey Weinstein have put the issue of sexual harassment back on the front page. What do you do if you are the target of harassment? How do you prevent a work environment where these behaviours are tolerated? HR Expert Debby Carreau weighs in.
8:20am Axe-throwing: It's called the "Clash of the Axes" at Harvest Haus…we try our hand at axe-throwing!
8:40am Best of Bridge: The 'Best of Bridge' ladies are back! We're in the kitchen whipping up Moroccan Chicken Stew just in time for fall.
Wednesday, Oct 11th 2017
7:40am Busting Winter Tire Myths: We tell you why you don't need snow to need snow tires when we bust the top 3 winter tire myths with tire expert Geoff Wiebe.
8:20am New Season, New Fitness Routine: Ready to take your workout indoors? Professional Obstacle Course Racer Allison Tai shows us how to get the most out of the most common and affordable pieces of fitness equipment. Plus, how to psyche yourself for a whole new range of exercise options that befit the new fall season.
8:40am Packing the Perfect Bag: Lifestyle Expert Tina Barkley shows us how to pack the perfect bag for everything from the gym to a weekend getaway with these Shoppers Drug Mart Top Picks.
Tuesday, Oct 10th 2017
7:40am World Mental Health Day: We talk to entrepreneur and former CFL linebacker Shea Emery about his experiences with depression and why "it's okay to not be okay".
8:20am Thor's Hammers: A late edition of Hammers as Thor reviews the highly-anticapted sci-fi sequel Blade Runner 2049 plus My Little Pony: The Movie.
8:40am How To Prevent & Treat Muscle and Joint Pain Naturally: Dr. Joyce Johnson explains why we experience soreness in our muscles and joints and the natural ways we can prevent and treat it.
Friday, Oct 6th 2017
8:20am Hall of Flame Calendar! We preview the 2018 Hall of Flame Calendar with members of the Vancouver Fire Department and learn about how it helps support a great cause.
8:40am How To Make The Perfect Pumpkin Pie: Just in time for the big Thanksgiving weekend, we get tips on making the perfect pumpkin pie from Gabi&Jules.


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Studying organisms as a whole for potential metabolic(ally) engineering of organisms for production of (bio)chemicals is essential for industrial biotechnology. To this end, integrative analysis of different –omics measurements (transciptomics, proteomics, metabolomics, fluxomics) provides invaluable information. Combination of experimental top-down and bottom-up approaches with powerful analytical tools/techniques and mathematical modeling, namely (quantitative) systems biology, currently making the state of art of this discipline, is the only practice that would improve our understanding for the purpose. The use of high-throughput technologies induced the required development of many bioinformatics tools and mathematical methods for the integration of obtained data. Such research is significant since compiling information from different levels of a living system and connecting them is not an easy task. In particular, construction of dynamic models for product improvement has been one of the goals of many research groups. In this Research Topic, we summarize and bring a general review of the most recent and relevant contributions in quantitative systems biology applied in metabolic modeling perspective. We want to make special emphasis on the techniques that can be widely implemented in regular scientific laboratories and in those works that include theoretical presentations. With this Research Topic we discuss the importance of applying systems biology approaches for finding metabolic engineering targets for the efficient production of the desired biochemical integrating information from genomes and networks to industrial production. Examples and perspectives in the design of new industrially relevant chemicals, e.g. increased titer/productivity/yield of (bio)chemicals, are welcome. Addition to the founded examples, potential new techniques that would frontier the research will be part of this topic. The significance of multi 'omics' approaches to understand/uncover the pathogenesis/mechanisms of metabolic diseases is also one of the main topics.
Systems Biology --- Metabolic Engineering --- Cell factories
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Transcription regulation is a complex process that can be considered and investigated from different perspectives. Traditionally and due to technical reasons (including the evolution of our understanding of the underlying processes) the main focus of the research was made on the regulation of expression through transcription factors (TFs), the proteins directly binding to DNA. On the other hand, intensive research is going on in the field of chromatin structure, remodeling and its involvement in the regulation. Whatever direction we select, we can speak about several levels of regulation. For instance, concentrating on TFs, we should consider multiple regulatory layers, starting with signaling pathways and ending up with the TF binding sites in the promoters and other regulatory regions. However, it is obvious that the TF regulation, also including the upstream processes, represents a modest portion of all processes leading to gene expression. For more comprehensive description of the gene regulation, we need a systematic and holistic view, which brings us to the importance of systems biology approaches.Advances in methodology, especially in high-throughput methods, result in an ever-growing mass of data, which in many cases is still waiting for appropriate consideration. Moreover, the accumulation of data is going faster than the development of algorithms for their systematic evaluation. Data and methods integration is indispensable for the acquiring a systematic as well as a systemic view. In addition to the huge amount of molecular or genetic components of a biological system, the even larger number of their interactions constitutes the enormous complexity of processes occurring in a living cell (organ, organism). In systems biology, these interactions are represented by networks. Transcriptional or, more generally, gene regulatory networks are being generated from experimental ChIPseq data, by reverse engineering from transcriptomics data, or from computational predictions of transcription factor (TF) – target gene relations. While transcriptional networks are now available for many biological systems, mathematical models to simulate their dynamic behavior have been successfully developed for metabolic and, to some extent, for signaling networks, but relatively rarely for gene regulatory networks. Systems biology approaches provide new perspectives that raise new questions. Some of them address methodological problems, others arise from the newly obtained understanding of the data. These open questions and problems are also a subject of this Research Topic.
Transcription Regulation --- Systems Biology --- network inreference --- transcription networks --- Transcription Factors
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The identification and mapping of protein-protein interactions (PPIs) is a major goal in systems biology. Experimental data are currently produced in large scale using a variety of high-throughput assays in yeast or mammalian systems. Analysis of these data using computational tools leads to the construction of large protein interaction networks, which help researchers identify novel protein functions.However, our current view of protein interaction networks is still limited and there is an active field of research trying to further develop this concept to include important processes: the topology of interactions and their changes in real time, the effects of competition for binding to the same protein region, PPI variation due to alternative splicing or post-translational modifications, etc.In particular, a clinically relevant topic for development of the concept of protein interactions networks is the consideration of mutant isoforms, which may be responsible for a pathological condition. Mutations in proteins may result in loss of normal interactions and appearance of novel abnormal interactions that may affect a protein's function and biological cycle.This Research Topic presents novel findings and recent achievements in the field of protein interaction networks with a focus on disease. Authors describe methods for the identification and quantification of PPIs, the annotation and analysis of networks, considering PPIs and protein complexes formed by mutant proteins associated with pathological conditions or genetic diseases.
protein interactions --- Protein function --- protein network --- Disease --- Systems Biology
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Since the discovery of the Warburg effect in the 1920s cancer has been tightly associated with the genetic and metabolic state of the cell. One of the hallmarks of cancer is the alteration of the cellular metabolism in order to promote proliferation and undermine cellular defense mechanisms such as apoptosis or detection by the immune system. However, the strategies by which this is achieved in different cancers and sometimes even in different patients of the same cancer is very heterogeneous, which hinders the design of general treatment options.Recently, there has been an ongoing effort to study this phenomenon on a genomic scale in order to understand the causality underlying the disease. Hence, current "omics" technologies have contributed to identify and monitor different biological pieces at different biological levels, such as genes, proteins or metabolites. These technological capacities have provided us with vast amounts of clinical data where a single patient may often give rise to various tissue samples, each of them being characterized in detail by genomescale data on the sequence, expression, proteome and metabolome level. Data with such detail poses the imminent problem of extracting meaningful interpretations and translating them into specific treatment options. To this purpose, Systems Biology provides a set of promising computational tools in order to decipher the mechanisms driving a healthy cell's metabolism into a cancerous one. However, this enterprise requires bridging the gap between large data resources, mathematical analysis and modeling specifically designed to work with the available data. This is by no means trivial and requires high levels of communication and adaptation between the experimental and theoretical side of research.
Systems Biology --- Metabolism --- Cancer --- Metabolic alterations --- Modeling --- Computational Biology
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During their life cycle plants undergo a wide variety of morphological and developmental changes. Impinging these developmental processes there is a layer of gene, protein and metabolic networks that are responsible for the initiation of the correct developmental transitions at the right time of the year to ensure plant life success. New omic technologies are allowing the acquisition of massive amount of data to develop holistic and integrative analysis to understand complex processes. Among them, Microarray, Next-generation Sequencing (NGS) and Proteomics are providing enormous amount of data from different plant species and developmental stages, thus allowing the analysis of gene networks globally. Besides, the comparison of molecular networks from different species is providing information on their evolutionary history, shedding light on the origin of many key genes/proteins. Moreover, developmental processes are not only genetically programed but are also affected by internal and external signals. Metabolism, light, hormone action, temperature, biotic and abiotic stresses, etc. have a deep effect on developmental programs. The interface and interplay between these internal and external circuits with developmental programs can be unraveled through the integration of systematic experimentation with the computational analysis of the generated omics data (Molecular Systems Biology).This Research Topic intends to deepen in the different plant developmental pathways and how the corresponding gene networks evolved from a Molecular Systems Biology perspective. Global approaches for photoperiod, circadian clock and hormone regulated processes; pattern formation, phase-transitions, organ development, etc. will provide new insights on how plant complexity was built during evolution. Understanding the interface and interplay between different regulatory networks will also provide fundamental information on plant biology and focus on those traits that may be important for next-generation agriculture.
Gene Regulatory Networks --- Plant Development --- Evolution --- Omics --- Molecular Systems Biology
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This volume contains 17 peer-reviewed papers based on the presentations at the 9th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2009) held at the Life Science Engineering Building of Boston University from July 27 to 29, 2009. This workshop started in 2001 as a platform for doctoral students and young researchers to present and discuss their research results and approaches in bioinformatics and systems biology. It is part of a collaborative educational program involving leading institutions and leaders committed to the following institutions and programs:Boston University Graduate Program in BioinformaticsCharité – Universitätsmedizin BerlinFreie Universität BerlinGlobal COE Program — Center of Education and Research for Advanced Genome-Based Medicine, University of TokyoThe International Research Training Group (IRTG) Genomics and Systems Biology of Molecular NetworksInternational Research and Training Program on Bioinformatics and Systems Biology, Kyoto University Bioinformatics CenterMax-Delbrück Center for Molecular Medicine in BerlinMax Planck Institute for Molecular Genetics in BerlinMax Planck Institute of Molecular Plant Physiology in Potsdam
Bioinformatics --- Systems Biology --- Computational Biology --- Genome Informatics --- Genetics
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This volume contains papers presented at the 20th International Conference on Genome Informatics (GIW 2009) held at the Pacifico Yokohama, Japan from December 14 to 16, 2009. The GIW Series provides an international forum for the presentation and discussion of original research papers on all aspects of bioinformatics, computational biology and systems biology. Its scope includes biological sequence analysis, protein structure prediction, genetic regulatory networks, bioinformatic algorithms, comparative genomics, and biomolecular data integration and analysis. Boasting a history of 20 years, GIW is the longest-running international bioinformatics conference.A total of 18 contributed papers were selected for presentation at GIW 2009 and for inclusion in this book. In addition, this book contains abstracts from the five invited speakers: Sean Eddy (HHMI's Janelia Farm, USA), Minoru Kanehisa (Kyoto University, Japan), Sang Yup Lee (KAIST, Korea), Hideyuki Okano (Keio University, Japan) and Mark Ragan (University of Queensland, Australia).
Bioinformatics --- Computational Biology --- Genome Informatics --- Computational Systems Biology --- Proteomics --- Genomics
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Protein phosphorylation is one of the most abundant reversible post-translational modifications in eukaryotes. It is involved in virtually all cellular processes by regulating protein function, localization and stability and by mediating protein-protein interactions. Furthermore, aberrant protein phosphorylation is implicated in the onset and progression of human diseases such as cancer and neurodegenerative disorders. In the last years, tens of thousands of in vivo phosphorylation events have been identified by large-scale quantitative phospho-proteomics experiment suggesting that a large fraction of the proteome might be regulated by phosphorylation. This data explosion is increasingly enabling the development of computational approaches, often combined with experimental validation, aiming at prioritizing phosphosites and assessing their functional relevance. Some computational approaches also address the inference of specificity determinants of protein kinases/phosphatases and the identification of phosphoresidue recognition domains. In this context, several challenging issues are still open regarding phosphorylation, including a better understanding of the interplay between phosphorylation and allosteric regulation, agents and mechanisms disrupting or promoting abnormal phosphorylation in diseases, the identification and modulation of novel phosphorylation inhibitors, and so forth. Furthermore, the determinants of kinase and phosphatase recognition and binding specificity are still unknown in several cases, as well as the impact of disease mutations on phosphorylation-mediated signaling. The articles included in this Research Topic illustrate the very diverse aspects of phosphorylation, ranging from structural changes induced by phosphorylation to the peculiarities of phosphosite evolution. Some also provide a glimpse into the huge complexity of phosphorylation networks and pathways in health and disease, and underscore that a deeper knowledge of such processes is essential to identify disease biomarkers, on one hand, and design more effective therapeutic strategies, on the other.
Protein phosphorylation --- Systems Biology --- bioinformatics --- evolution --- network biology --- Human Disease --- kinases --- Phosphatases --- protein structure
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The phenotype of a plant in response to a stress condition is the reflection of the molecular responses in different cell-types composing the plant. The multicellular complexity represents a challenge when accessing specific responses of each cell or cell type composing the plant. To overcome this difficulty and allow the clear characterization of the plant cell molecular mechanisms, the research community is now focusing on studying a single cell and single cell-types. The isolation of plant single cells is limited by the cell wall that confers the rigidity of the plant and its overall structure. Various methods have been developed for isolating plant cells (e.g. laser capture microdissection; cell sorting of Green Fluorescent Protein (GFP)-tagged protoplasts, differential protoplastization of cells such as guard cells, isolation of easily accessible cell types such as cotton fiber, pollen cells, trichomes and root hair cells). The development of these innovative approaches to isolate single plant cells or cell-types combined with the application of sensitive and high-throughput technologies allows a better analysis of the developmental processes and response to environmental stresses. Ultimately, single plant cell and cell-type biology will lead to establishment of more reliable and accurate -molecular regulatory networks at the resolution of basic life unit. The goal of this Research Topic is to cover new technological and biological advances in the study of plant single cell, cell-type and systems biology.
Systems Biology --- molecular phenotype --- -omic analyses --- single cell types --- root hair --- Trichome --- guard cell --- plant reproduction
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Aims and Scope: The Research Topic is designed to feature the latest innovative and leading-edge research, reviews and opinions on the study of complex and dynamic processes related to the mammalian immune system and cancer. All papers were meticulously selected to present our readers the multidisciplinary approach to tackle the existing challenges faced in these important fields. From high throughput experimental methodologies to computational and theoretical approaches, the articles are intended to introduce physicists, chemists, computer scientists, biologists and immunologists the idea of systems biology approach to the understanding of mammalian immune system and cancer processes. Attention was given to works that developed more effective approaches to the treatment of proinflammatory disease and cancer. The strong interdisciplinary focus will discuss biological systems at the level from a few molecules to the entire organism. Specific focus domain includes: Innate and adaptive immunity, cancer and cancer stem cell, genomic, proteomic and metabolic analysis, imaging, biophysics of immune and cancer response, computational modeling, non-linear analysis, statistical analysis, translational and disease models Types of articles: Viewpoint, commentaries, research letters, research articles, review and methodologies
Systems Biology --- High dimensional data --- immunology --- Cancer --- plasticity --- Computational Biology --- statistics --- Nonparametric


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I very much like to make things for my friends when they have a birthday or other special event. Really I do. The problem is that I always seem to end up pretty far behind schedule. So, last night, since it was the night before Natalie's birthday, I was finishing up on Rachel's birthday present. Because you see, Rachel's birthday was about two weeks ago and it was necessary to finish her present before I could finish Natalie's. So today when we all had lunch for Nat's b-day, Rachel got a present. That's how things work around here.
Anyway, I used the scarf pattern from Denyse Schmidt's really great book, and although most of you do not know Rachel, she's kind of awesome, so I busted out some of the good stuff from my fabric stash in her honor. This included some of my Lara Cameron ginkgo linen as well as some long hoarded Mary Flanagan wool felt. I also used up some wool scraps that I had left over from a couple of random winter projects as well as some quilting cotton. I had my doubts when I was piecing the thing but when it was finished I decided that I really liked it and that it was fun enough to make that I'll probably use the pattern again. I also realized that I shouldn't feel badly about how much I hesitate to cut into fabric that I really love (a serious habit of mine) because apparently, when the right project comes along, I'll do it without thinking twice.


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Gender Roles in China – How Women are Faring
Historical Roles of Women Compared to Men
In China, men have historically been the core of the family, and it can be argued that they still are today. Whether it was a Shang or Zhou dynasty king, they only made sacrifices for their patrilineal ancestors i.e. the father of their fathers, the fathers of those fathers, and so on. In fact, women only really enter the ancient Chinese historical record if they caused the men problems. In the time of Confucius, women's roles were only regarded as kinship roles – daughter, sister, wife, daughter-in-law, mother, mother-in-law, and widow. In the centuries following Confucius, writers commonly spoke of women in the context of yin and yang. While men were yang, women were yin – yin representing soft, receptive, yielding, passive, and tranquil. A Confucian classic, Book of Rites, was followed closely for a long time and stressed segregation within the home. Women were meant to be in the inner section of the home and "not take part in public affairs", while men were meant to be in the outer portion of the home.
Continuing to Han times, The Biographies of Exemplary Women included cautionary tales on scheming, jealous, and manipulative women bring destruction around their homes and families. The state of women particularly declined in the Song period. In this period, women were were pressured not to re-marry when widowed and this period is when foot-binding became common. At the time, foot-binding was seen as a way for Chinese women to beautify themselves and was also associated with the "pleasure quarters". In addition to being focused on beauty and pleasure instead of the woman's potential and skills, it also made women less mobile, further contributing to the lesser status in society than men. Essays and entire books have been written about the history of women suppression in China, but I will move on to discuss the current status of the status of women in Chinese society.
Roles of Women Compared to Men in Present Day
Since the historical times aforementioned, women have made some progress in China, but are nowhere near equal to men. Private businesses in China have helped with the movement towards equality. While there is still "outright hiring discrimination" based on gender (according to one survey conducted in 2015 by the state-run All-China Women's Federation, 87% of women university graduates experience this discrimination when job seeking), the most gains are being made in the private business sector, particularly technology companies, where women have more direct control over policies. In these private companies, the growth of revenue far exceeds the growth of state-owned companies – giving them a louder voice against the patriarchal culture of China. This is important since a woman has never been president, nor held a seat in the elite Politburo Standing Committee.
However, setbacks still exist. At Zhenjiang's College in Southern China, a new course launched in March 2018 that teaches women how to dress, pour tea, and sit as women should, i.e. sitting only on the front two thirds of the chair, with the belly in, shoulders relaxed, and legs together. To emphasize the censorship of China, The Washington Post was the first foreign media outlet granted access to Zhenjiang's campus and could only interview students if the teachers were present to listen in. This course was launched shortly after President Xi abolished term limits to China's presidency and exists in the name of his "new era". Since the start of President Xi's presidency, the World Economic Forum has dropped China's global gender gap index significantly, from 69 in 2013 to 100 in 2017, out of 144 countries. Clearly, the current presidency is not boding well for women's equality in China.
Finally, Chinese women have been inspired by the #MeToo movement in the United States, but have found difficulty in organizing their own far reaching #MeToo movement, as they are going up against the ruling of the Communist party in addition to the traditional patriarchal culture of China. Government censors have been blocking phrases such as "anti-sexual harassment" on social media and petitions calling for better protections for women. It's also difficult for women to speak out because of the culture of "respecting the hierarchy", according to Professor of Psychology and Vice President of the Chinese University of Hong Kong, Fanny M.C. Cheung. Despite these obstacles and the fact that the movement is pretty limited to educated, urban women, the movement is still present. As one female Chinese journalist, Sophia Huang Xueqin stated, "we're not brave enough to stand as one individual. But together, we can be strong."
New York Times – 'Me Too' Chinese Women Say. Not So Fast, Say the Censors. (link in picture below)


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Madhav, a street racer, and Rajasekar, a traffic police officer, have always been at loggerheads. Their cat and mouse chase goes for a toss when Rajasekar and Madhav`s sister get married.
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In the event you have a very simple, uninspiring pool location, or maybe you happen to be exhausted of that gravel driveway, then it is time to talk into a masonry work montville nj contractor. These industry experts do a lot more than simply pour cement or concrete right into a room. In fact, many of them are gifted artist who will just take a uninteresting, uninviting area and switch it into stunning artistic endeavors. Their decades of practical experience and awareness enable them to be aware of precisely tips on how to take that simple space and help it become a watch catching area.
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Acid stained concrete – This can also be carried out inside a assortment of colours. After the concrete is poured and has established, the concrete is sealed and polished to produce a good looking flooring. Acid staining will generate pure coloration variants and molting outcomes that always seem like marble or granite. However, acid staining shades are usually confined to delicate earth tones and shades of blue and environmentally friendly.
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BOSTON, Mass. — T'Andre Cephas-Harris loves basketball. He also has a severe form of asthma, but that isn't stopping the 7-year-old from joining the world of college hoops.
T'Andre, who lives in Dorchester, is the newest draftee of the men's basketball team at Boston University.
"He made basketball hoops out of crates, boxes anything he could possibly hang on the walls," said his mother, Sherika Elliott.
T'Andre, who has been hospitalized more than 20 times for his asthma, can't play basketball outside once the weather gets cold. So his mother looked for a place where he could play hoops indoors during the winter.
That's how she learned about Team Impact, which connects sick kids with college teams.
"For the kids we're really looking to improve their quality of life, through improved optimism, a sense of belonging, to help remove that sense of isolation," said Seth Rosezweig of Team Impact.
T'Andre was welcomed onto the BU team with a press conference, a uniform and multiple hugs from the mascot.
BU Basketball Coach Joe Jones said Team Impact is a two-way street.
"We want to be part of the community. We want to give back. We have such great kids that can be mentors to young people and we want them to understand that's what life is all about," Jones said.
This is only the second time the BU men's basketball team has drafted a Team Impact kid. The last time was six years ago in 2012.
Jones said he still stays in touch with that draftee, because a bond develops.
And now, T'Andre has joined 14 men to make one awesome team.
"Thank you," T'Andre said.
The team kicks off its season on Tuesday night.
© 2020 Cox Media Group


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Organisers of the long-established PDM Event have confirmed that the 2018 edition of the UK's annual exhibition and conference covering all aspects of plastics design and manufacture will return to its traditional home at the Telford International Centre on June 19-20, 2018.
The show will incorporate multiple elements of the plastics industry, with a focus on design, moulding, packaging and recycling. Exhibitors will include product design companies, moulding machinery suppliers, toolmakers, rapid prototyping specialists, moulders and mouldmakers, plastics recycling specialists, masterbatch specialists, software suppliers and materials testing specialists.
The free to attend PDM conference runs on both days of the event and will cover the latest in plastics design and manufacture including moulding processes, rapid prototyping, materials innovation, plastics recycling and sustainability issues. Featuring speakers from different sectors of the UK plastics industry, the conference sessions will include examples of innovative approaches in design, new technology within moulding in both materials and machinery - as well as scientific discoveries in the field.
Supported by major industry trade associations, PDM Event is the place to meet a cross-section of the industry, from existing customers and contacts to brand new leads and business opportunities.
"We are delighted to confirm that PDM will return to its established home of the Telford International Centre in June 2018,", said Matt Barber, Event Director at organiser Crain Communications. "Feedback from our exhibitors and visitors alike has encouraged us to return to the event's core strengths as a plastics design, manufacturing and recycling event, including both an exhibition and free conference, as well as to return to our traditional and very popular venue of the Telford International Centre."
Mark Lawson, Managing Director, of PDM exhibitor LawsonKeys said of the event: "We are looking forward to exhibiting again at PDM 2018. 80% of the business we secure is from customers we have invited to come to see us at PDM. It's a must-attend event for us; it is a well-organised event and the logistics involved are easy."
PDM 2018 is the perfect place for plastics and design professionals to network, learn and do business. Industry associations supporting PDM 2018 include: the British Plastics Federation (BPF), plastics recycling organisation RECOUP, the Society of Plastics Engineers (SPE) and the Gauge & Toolmakers Association (GTMA).
Home to over 100 polymer-related companies, Telford has been known for "plastics valley" for over 20 years and was the venue for PDM's debut show in 2005. Easily accessible from the M6 and M54 motorways, the Telford International Centre provides free parking for over 1,500 cars. The adjacent Southwater development offers visitors and exhibitors a choice of bars, restaurants and post-event entertainment


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Charts and Readings by Sandra
Secondary Progression & Planetary Transits
As we grow older, our chart grows older with us. It describes the mature person you have become, adding perspective to your life. Aspects of one progressed planet to another indicate personal, psychological, and instinctive developments in real time.
The planets and luminaries' positions can be forecast reliably, as can the respective cycles of your future life. Aspects from progressed planets to natal planets & angles indicate events in real time and will help you to determine your best course of action
Solar Return Chart
This outlines your yearly cycle of transformation & growth by erecting a chart for the time that the transiting Sun returns to the position of the natal Sun. Once a year at a specific time, the Sun returns to this position making a statement of intention and/or affirmation concerning what your soul believes it can hope to manifest throughout the following year.
The Solar Return Chart provides
consideration of all aspects of your future development and evolutionary process for your solar return year.
NATAL or BIRTH CHART
This is your Spiritual Owners Manual & template for living in the 3rd dimension
Horary Astrology
The Art of answering questions
This offers insight to issues which surface at times of confusion or crisis. A question is asked and a chart drawn for that moment. I will then translate the chart to provide the answer.
Love and Relationships
Synastry &
Composite Charts
Comparing or Combining two charts to assess their compatibility in all areas of personality and life style. Useful for marriage, business partnerships and parenting.


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