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AAPS Newsmagazine, ADME, Drug Candidate Selection, Michael Bolger, Michael Lawless, PBPK, Siladitya Ray Chaudhuri
By Siladitya Ray Chaudhuri, Michael B. Bolger, and Michael Lawless
Establishing a therapeutically beneficial new chemical entity (NCE) can be broadly classified into research (discovery) and development phases. Drug development is generally divided into nonclinical (animal) and clinical (human) testing stages, with regulatory approval of an investigational new drug application separating the two. In contrast, drug discovery does not require regulatory oversight and follows the general path of: target validation —> assay development —> high-throughput screening —> hit to lead —> lead optimization (LO). Promising drug candidates are selected and transitioned from late LO into nonclinical development, although the specific processes for doing so vary between organizations.
Along with potency and safety, a third key factor in determining an NCE's viability as a potential clinical drug candidate is its ADME (absorption, distribution, metabolism, and excretion) properties. In the not-so-recent past, poor ADME properties were responsible for more clinical drug trial failures than efficacy or safety. Typically ADME properties are initially evaluated in early lead optimization with in vitro experiments, while more specific and resource-intensive in vivo exposure data is collected during later stage drug candidate optimization and selection. Both in vitro and in vivo data are used to assess for liabilities such as poor bioavailability, high clearance, potential for drug-drug interactions, etc. A more thorough mechanistic understanding of how ADME properties can be optimized has evolved in the past decade or so, which has enabled pharmaceutical scientists to select more robust NCEs. This enhanced understanding also enables earlier stage in silico modeling and simulation.
Human exposure predictions during the nonclinical development phase have also improved. Historically, compartmental pharmacokinetic (PK) methods have used allometric scaling of preclinical animal data to predict exposures in humans. In compartmental PK, the body is arbitrarily represented by either one or several theoretical compartments without specifying anatomy and physiology. These analyses, however, require in vivo data, which is often unavailable during early compound optimization. Furthermore, allometric scaling in simple compartmental models has no mechanistic basis, which can limit the predictive ability.
Physiologically based pharmacokinetic (PBPK) methods are an alternative approach to address these challenges. Although the concept of PBPK modeling is not new, its use within the pharmaceutical industry has been limited until recently following regulatory acceptance by the Food and Drug Administration. The PBPK approach utilizes anatomical and physiological parameters for either in silico/in vivo extrapolation or in vitro/in vivo extrapolation, which predicts full PK in animal species or humans. These predictions require only a compound's in silico or in vitro ADME properties. A significant disadvantage of PBPK has been the complexity, requiring hundreds of differential equations and biopharmaceutical parameters. This shortcoming, however, has been rectified in whole-body PBPK models incorporated within several commercially available software products such as PK-Sim (Bayer Technology Services), Simcyp (Certara), and GastroPlus (Simulations Plus, Inc.).
Traditionally PBPK modeling and simulation is used in the late nonclinical to early clinical development space to support dose selection for first-in-human studies, potential drug-drug interaction effects, and possible exposure differences resulting from a change in formulation. This powerful methodology can, however, also be employed in the early to late discovery stage as discussed through in case studies in the AAPS Newsmagazine June cover story from the Drug Discovery and Development Interface section.
How significant are in silico ADMET property estimations in decision making at the interface of drug discovery and development?


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Rob and his Instagram
His suggestion is a new take on the interactive aspect of the Instagram app. And the result is more than impressive. As we had a few questions, we grabbed him for a little interview. Read for yourselves what he has to say about his work.
Hi Rob, why did you develop a new Instagram design in the first place?
For one reason only: when I'm using something on a daily basis and love the basic function of it, but see enormous potential for improvement, then it only stands to reason that I'm going to want to adapt it.
What was the biggest challenge for you?
The improvement itself. Many redesigns are only about improving the appearance. My goal was to improve the app. To make the important functions stand out, and scale back less important ones.
So it's not only a "reskin", but an overhaul of the entire UX. How far did you go with the concept development?
I started out by first questioning every function and then classified them according to importance. For me the focus was definitely on the redesign of the user navigation, which in turn required adaptations in the design. It was important to me to optimise the functionality of the app and initiate new ways of looking at it. An example of this are the gestures on all touch devices, which in my opinion are often not incorporated into the UX enough. It rarely goes beyond a swipe-left to the menu or a swipe-down to scroll – there's a lot more potential there.
How much time did you spend on it?
As it was, and still is, a project I work on in addition to my day job, it's hard to speak in terms of working days, but roughly speaking I invested two evenings on the concept, one Saturday on the design and two evenings on the presentation. But before I began, I already knew which screws needed tightening in order to achieve the result I was aiming for.
Instagram has now initiated a redesign itself: do you believe they are following a trend that you also saw, or what chances do you think flat design will have?
Yes, around three weeks later an urgently necessary update came, but it was only reduced down to the UI and that's why I think it comes from the "IOS7 redesign wave". With this style they're certainly following a trend, but before the decision between flat design, skeuomorphism or similar styles is made – especially with applications – there should always be a focus on the actual function. And that is precisely where I see a big potential of flat design. Fewer distracting elements and details, more focus on the content and the function. However, the result of this also means higher expectations in terms of getting the right proportions and the suitable weighting of the elements. So I'm looking forward to seeing where this trend will take us in the near future.
Have you already received a lot of feedback about your work?
The first week was really interesting and I have to admit that during that time I probably opened the Behance app four times more than unusual and not even 10 minutes could go by without my display showing some kind of a notification. Encouragement like that is great of course and makes the work that I put into it even more worthwhile.
And has there been any criticism?
There's bound to have been – which pleases me, as it shows that people are really getting to grips with it and not just skimming over the case.
Apart from the redesign, you are using Behance for yourself as a platform. Why?
Behance offers an enormously well-developed platform for specialists of the most diverse disciplines and a comparably simple opportunity to make your work accessible to many people. For example, almost 8600 people have viewed this case so far and more than 800 have liked it. And I was all the more pleased when I got the e-mail that the case had been chosen as the "Featured Project" on "Behance App Design Served".
What project is next in the pipeline for you? Or was this just a one-off?
I'm planning to launch my portfolio at the end of the year, that's what's taking up most of my time right now. However, I still have quite a few other projects on my to-do list. But I don't know yet which order I'll tackle them in or when the next one will happen.
Great, thank you!
It was a pleasure.

subset: commoncrawl


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The National Golf Club
Cape Schanck Australia
Click to Email
The original National course (Old Course) was open for play in 1988 and was designed by leading golf course architect Robert Trent Jones Jnr. This course is a generally hilly course combining amazing coastal views, challenging ball carries and slick, undulating putting surfaces into a test of golf not previously seen in Australia. A number of holes provide spectacular views with the standout hole in terms of beauty being the 7th hole. A par 3 of 135 metres, it plays over a cavernous ravine to a large green which runs from left to right. The backdrop to this hole is the coastline of the Mornington Peninsula heading down to Portsea. There is really only one place to hit the ball...on the green. The course comprises a number of holes with ocean views, a number of "inland holes" and all are framed by the natural tee tree and Moonah trees which are common on this part of the Mornington Peninsula.
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Our knee high boots 'Heartsmile' is a new season must-have. Soft microfibre material paired with a chunky mid heel means this boots is really comfortable whilst the strap and buckle detail will catch everyone's eye.
- Heel height: 60mm
- Microfibre
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- 100% Suedette.
- Wipe Clean Only.


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New to Sophia?
This lesson demonstrates how to write an inequality using variables.
Sophia's self-paced online courses are a great way to save time and money as you earn credits eligible for transfer to many different colleges and universities.*
Sophia partners
credit transfer.
Institutions have accepted or given pre-approval for credit transfer.
* The American Council on Education's College Credit Recommendation Service (ACE Credit®) has evaluated and recommended college credit for 32 of Sophia's online courses. Many different colleges and universities consider ACE CREDIT recommendations in determining the applicability to their course and degree programs.
In this lesson, we'll interpret some crazy word problems and translate them into the language of math -- this time as inequalities (e.g., 3x < 15), rather than equations (e.g., 3x = 15).


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Could Weston High Street receive £25m cash boost?
PUBLISHED: 16:00 11 February 2019
Weston-super-Mare's struggling High Street, after suffering a series of bitter blows, could benefit from a multi-million-pound cash injection.
The Government has launched the Future High Streets Fund (FHSF), a £675million kitty which will be handed out to local authorities in hope of revitalising town centres.
Authorities can benefit from a windfall of up to £25million from the fund and North Somerset Council is expected to put Weston forward in the bidding process.
The town's High Street has suffered several closures in recent years despite efforts to regenerate the town centre – the most damaging of which coming in January as Marks & Spencer announced plans to end its century-long stint in central Weston.
Big names like BHS, Topshop, Game and Thorntons have turned their back on the town, as spending trends continue to shift to online shopping.
But the council hopes to reverse the trend by securing a share of the funding.
Its spokesman said: "The FHSF will be offering up to £25million for high streets and town centres, with most successful bids expected to be in the region of £5-10million.
"We will be bidding and we are currently in the processes of reviewing which area best fits the criteria set by the Government. Phase one of the bid will be put forward at the end of March."
The Government hopes the fund will drive changes to town centres which future proof them against the growing dominance of online shopping and restore high streets as a focal point for communities.
The FHSF prospectus says: "High streets lie at the heart of our communities and local economies, creating jobs, nurturing small businesses and injecting billions of pounds into our economy.
"But the way we shop and the way communities use their high streets is changing: we're shopping more online, making fewer big shopping trips and shopping 'little and more often'. This changes the nature of what makes a high street successful.
"The Government is committed to helping high streets evolve and adapt to these changes. We want to encourage vibrant town centres where people live, shop, use services, and spend leisure time.
"The FHSF will support and fund local areas' plans to make their high streets and town centres fit for the future."
If you value what this story gives you, please consider supporting the Weston Mercury. Click the link in the orange box above for details.


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Covestro's PCS sheets business located in Sheffield (US), which generated sales of approximately $170 million (approx.. £120m GBP) in 2017, has been sold to US-based acrylics sheets manufacturer Plaskolite.
German-based materials manufacturer Covestro says the move is part of its strategy to optimise the company's portfolio.
The deal will be conducted as an asset deal, where the transfer of dedicated intellectual property, fixed assets and employees will join Plaskolite.
Operations will continue at the current facility, with the closing deal expected to be completed in the third quarter of 2018.
"We continuously evaluate and optimise our portfolio to secure future growth and value creation. During that process it became clear that our sheets business will not be a strategic fit to our Polycarbonates business in the long term," said Patrick Thomas, Covestro CEO.
"We therefore decided that it can develop and grow better under a new owner and we are happy to have found a great buyer for our US outlet with Plaskolite."
The company will soon open a separate bidding process for its outlets in Europe and shortly after details regarding its remaining outlets in the Asia-Pacific region will be announced.


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Iconic Southern brand continues expansion in the Mid-Atlantic region
Today, Bojangles', Inc. (NASDAQ: BOJA), the popular, fast-growing restaurant operator and franchisor, announced a multi-unit development agreement with new franchisee MSR Restaurants, LLC of Mitchellville, Maryland.
The development agreement is anticipated to result in multiple new Bojangles' restaurants in the Washington, D.C. metro area over the next several years. The franchise group is owned and operated by Baryalay Razi, who has more than 20 years of experience in the quick service restaurant industry.
"We are pleased to welcome MSR Restaurants, LLC to the Bojangles' family of franchisees," said Randy Icard, Bojangles' Vice President of Franchise Development. "We are confident that MSR Restaurants, LLC is the right franchise group to align with as we move forward with our strategic growth and development plans. We continue to actively search for successful, enthusiastic business leaders, like the MSR Restaurants team, to increase our brand presence in the Mid-Atlantic region."
The company has been actively expanding its footprint, recently signing agreements to bring Bojangles' into Pennsylvania's Lehigh Valley region and Virginia's Chesapeake Bay area.
Additionally, Bojangles' has recently refranchised its Maryland restaurants in New Carrollton, Hillcrest Heights, Landover, Upper Marlboro and Oxon Hill, which are now independently owned and operated by MSR Restaurants, LLC.
Since 1977, fans have enjoyed Bojangles' made-from-scratch offerings. The company's Cajun-inspired menu includes fresh, never frozen, hand-breaded chicken; buttermilk biscuits freshly made every 20 minutes; flavorful fixin's like green beans and Cajun Pintos, and Legendary Iced Tea.
While the food is great, so is the brand's vision. Bojangles' has invested in the development of a dynamic new restaurant design, which will bring a modern ambiance to complement its freshly-made, high-quality food and restaurant hospitality. Learn more about the new design here.
For more information about franchising at Bojangles', visit Bojangles.com/Franchising.
Bojangles', Inc. is a highly differentiated and growing restaurant operator and franchisor dedicated to serving customers high-quality, craveable food made from our Southern recipes. Founded in 1977 in Charlotte, N.C., Bojangles' serves menu items such as delicious, famous chicken, made-from-scratch buttermilk biscuits, flavorful fixin's and Legendary Iced Tea. At December 25, 2016, Bojangles' had 716 system-wide restaurants, of which 309 were company-operated and 407 were franchised restaurants, primarily located in the Southeastern United States. For more information, visit www.bojangles.com or follow Bojangles' on Facebook and Twitter and Instagram.


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very pretty clusters. very clean. love it.
edit: I would have handled the clustering in the background bushes differently. but that is a minor detail. I like how you rendered the shop a lot. and that is the main attraction.
Great image! Although beautiful, can you please remove the artificial glow effects? This is not allowed in the Pixel Joint gallery.
Rule #6. "Any art you post should be PIXEL ART! Pixel art implies that each pixel is placed by hand (no filters, paintbrushes, gradient fills, etc)


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Cops: Suspect tased after repeatedly 'charging at officers'
STAMFORD — A disturbance call turned ugly Tuesday night when police had to use a taser to subdue an extremely intoxicated man.
Stamford Police Sgt. Robert Shawinsky said officers responded at about 11:30 p.m. to a residence in the 100 block of Washington Boulevard.
When they arrived, Shawinsky said officers saw the caller and another person trying to calm down a "highly-intoxicated, emotional male," identified as 25-year-old Eric J. Santiago, of Miami, Florida.
Shawinsky said the complainant told police Santiago had fallen on hard times and she was allowing him to stay with her for a few days while he got back on his feet.
When one of the officers attempted to speak to Santiago, Shawinsky said Santiago charged at the officer, and the officer "pushed him down onto the couch to protect him from hurting himself."
Santiago was ordered to stay put and stay down, Shawinsky said, but he got up and again lunged at the officer.
"At that point, the officer had to deploy his taser, striking Santiago in the upper torso," Shawinsky said.
Santiago was taken into custody and, as a matter of department policy, was taken to Stamford Hospital where the taser prongs were removed.
Santiago was charged with interfering with an officer/resisting arrest and two counts of disorderly conduct.


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Hypnotherapy is a variety of therapy, where a patient as well as a hypnotherapist work out the beliefs the affected person holds about themselves which might be false and are holding them back. Hypnosis is then employed to allow the subconscious mind to modify these beliefs to say yes to move forward and change your attitudes or habits.
Main Role
A hypnotherapist will explore issues around a patient's negative thoughts to develop a profile of the problem. Usually a problem will could be broken down into various specific areas. The hypnotherapist must design a specific hypnosis session for all these, which are spread over a few weeks of treatment for the affected person. You can get reliable help through experts by visiting melbournecognitivehypnotherapy.com.au/.
During the hypnosis the hypnotherapist is required to relax the patient as much as possible. Therefore, it is important that the patient feels completely more comfortable with their hypnotherapist.
The hypnosis itself might take different forms. Types regarding Hypnotherapy include:
Suggestion Hypnotherapists
Analytical Hypnotherapy
Cognitive Hypnotherapists
There usually are, currently, no laws in the united kingdom for the training and registration of hypnotherapists. Nevertheless, you need to be over 21 years old as life experience sometimes appears as invaluable.
Many hypnotherapists work at home, putting aside a space in their house with regards to hypnosis treatment. Others work just a holistic practice or within just health centres, with additional therapists. Some hypnotherapists are mobile and visit client's homes and offices to manage them there.
How much you earn depends on in your geographical area. A session can differ from between £100 and £35 by the hour depending on experience and location.


text: Read With The Gringa "Skippyjon Jones Mummy Trouble" 15 minutes of exciting reading with the Gringa! All kids should watch! 30.133274 -95.441392 Montgomery County, TX, USA Share this:TweetEmailPrintLike this:Like Loading... Related Published by gringaofthebarrio A barrio gringa with a dream of cosmic proportions: writing to satiate my insatiable curiosity, worldwide literacy beginning with our youth, and to be the first barrio gringa to explore outer space! View all posts by gringaofthebarrio


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FORT INDIANTOWN GAP, Pa. – Pennsylvania Soldiers with Bravo Company and Delta Company, 2-104th General Support Aviation Battalion, 28th Expeditionary Combat Aviation Brigade, received a mobilization order for Operation Freedom's Sentinel and are scheduled to deploy in late 2019.
Over 50 Pennsylvania Army National Guard Soldiers will be part of this deployment. The units are based out of Fort Indiantown Gap and Johnstown but Soldiers come from all over the commonwealth and some even reside in neighboring states.
Soldiers were notified of this deployment prior to the official release to allow their families and employers the maximum amount of time to prepare.
"We always strive to support our Soldiers' families and it becomes even more critical when their loved ones deploy overseas," said Col. Howard Lloyd, commander of the 28th ECAB. "We are also focused on doing what we can to alleviate the known stress on their civilian employers."
Operation Freedom's Sentinel is part of the Global War on Terrorism and is the official name for the mission succeeding Operation Enduring Freedom. Terrorist groups like ISIS and Al-Qaeda still function in the OFS area of operations and remain a threat to international stability, peace and safety.
Bravo Company Soldiers operate CH-47 Chinook helicopters and Delta Company Soldiers provide aviation maintenance. They will work with partner units to prevent these terrorist groups from launching attacks against Americans or their friends around the world.
More information will be published as their mobilization grows nearer, including highlights of their pre-mobilization training.
Media contact: Capt. Travis Mueller, (703) 943-7522
|Date Taken:
|Date Posted:
|06.09.2019 15:52
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This work, Pa. Guard aviation units to deploy later this year, must comply with the restrictions shown on https://www.dvidshub.net/about/copyright.


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Day 358: Drive and a Moment of Momentum
Reading through my previous writing, which set forth from the starting point of Drive, I noticed how I represented me as standing on a junction of the roads, surrounded yes by traffic, cars, and drivers; but also that I was surrounded by lots of moments, other people's moments, pigeon's moments, moments everywhere flying all around me, and past me, in the traffic.
And something that I did not see was how this word Moment was here for me, all around me, you could say in a way trying to catch my attention, but I had not stepped back from this enough to see, till later on, when in a completely different context the word came up again, within Momentum, and then I saw how for me Momentum could become for me a part of Drive.
How I came to this was looking into the word Moment, and considering that there are these things called moments in my life; not measurements of 'time' exactly, more like parts of life, where for me a moment of my life is kind of intimate and personal in a way, that in a world that had no clocks or hours or seconds, there would still be moments of my life, moments of awareness here.
It is like that within this there is a realization for me that I can actually live these moments of my life; that they belong to me, as part of me, that this then is actually for me real-time, in which who I am within this is what is real, and in that how I move myself within these moments, is how I can see that I could live momentum, sort of utilizing these moments of my life as me, in which I move myself within these moments.
I forgive myself that I have accepted and allowed myself to not see how for me I could not find access for myself in real-time, and that I have instead accepted and allowed myself to suppose that I could accommodate myself to that. I forgive myself that I have accepted and allowed myself to be not considering me as in this life as me in this relationship that I made to real-time. I forgive myself that I have accepted and allowed myself to be as less than real-time in this relationship. I forgive myself that I have accepted and allowed myself to define real as something that is out there, as something that I must aspire to live. I forgive myself that I have accepted and allowed myself to believe that I can somehow live an idea of time that is in my mind.
See Eqafe's: The Key to World Change
See Also on YouTube: One Word Opens many Doors
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SOUL – The School of Ultimate Living is an online community of people interested in
discovering and developing their utmost potential
eqafe.com – Invest in a wide range of Interviews and Support yourself to Self Perfection
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DIP PRO -A Desteni Course for those Ready to Walk the Journey to Life


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When it comes to functioning effectively in your day to day home life, I'm sure many would agree that ensuring that your electricity, appliances, and electronics are functioning correctly is essential. I was reminded of this when I woke up last week and discovered that the electricity in my home was working at all. I automatically assumed that there was an outage because I knew for a fact, I had paid the electricity bill but, but after scoping out the neighborhood, asking a few neighbors and calling the electricity company it seemed that the problem was on my end. Since I was a homeowner, I didn't have the benefit of contacting like I was able to do when I lived in my apartment a few months ago. I had to find an electrician and I had to find one quickly. The food in my refrigerator was already defrosting and I was sticky from the summer heat. No electricity meant no air conditioner, I couldn't use my laptop, watch TV or even charge my cell phone.
You can start an online search for any electrical contractors chicago il you will have a vast amount of results When you are spending your hard-earned money and you are inviting someone into your home to complete work for you it is imperative to ensure that they are going to be fair, prompt and professional. I knew that there were many people who did side jobs at lower prices and I wanted to be sure that the person or company chose to work with was certified. It was nearly impossible to decipher the right company or person to call so I decided to start at the top of a list of contractors that I found and work my way down.
The city of Chicago's official site provided me with the name, address, phone number and license expiration date of all certified electricians in the Chicago area. With a little due diligence, I was able to find an electrician that could come out the same day, that had excellent reviews and that was willing to give me a free quote.
I only waited about an hour for the electrician to arrive and he made every step of the process easy for me. Once he identified the problem, he provided me with a quote and advised me that he could get started the same day if I wanted him to. I have to say that I was relieved and impressed by the service that I received and the plus side was the work turned out to be minor and didn't cost much for the repairs to be done, but I think that selecting the right contractor had a lot to do with the outcome. Had I not done my research I may have ended up spending thousands of dollars on unnecessary fixes made by an unlicensed contractor.


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There are many reasons why you will one day find yourself in a situation where you need to sell your house, and fast. Whether its a job promotion for a post in another state, additions to the family that will require bigger space, or a sudden financial downturn, selling your home can solve a lot of problems especially if you want a fast sale and earn a profit at the same time. Here are 5 effective tips on selling a house in San Antonio, TX.
How your house looks from the street can help you attract potential buyers. This is also very easy and relatively inexpensive which is perfect if you want to avoid putting more money on the property. Look at your house from the street and pick out the areas that need improvement– an unkempt lawn, overgrown hedges or trees, exteriors that need to be repainted, rusty gutters and the like. With some pruning shears, a leaf blower and some leftover paint you can start improving the look of your home and give prospective buyers a positive first impression when they come around.
Staging means giving the home a cozy, inviting and comfortable vibe. Colorful curtains, new pillows on the couch, fresh flowers, candles on the dining room table and a stack of interesting coffee table books on the living room table will give serious San Antonio home buyers the impression that they are looking at a showroom exhibition that could easily turn into their dream home. Depersonalization is also crucial in this day and age. Remove any traces of family photos on the walls, hide piles of clothes, and your kids' toys. You want to create a space that makes it easy for prospective buyers to imagine their own families and lifestyles in your home.
Knowing how to price your home can be tricky. You need to consider median prices for homes of the same size in your neighborhood, the cost of your upgrades and other factors. If you want to sell your house but also want to make profit out of the sale, working with a professional real estate agent in Texas can help you do both. A real estate agent knows the Texas real estate market and can help you come up with a competitive price that is reasonable enough for a quick sale.
If you have active Facebook and Instagram accounts, post images of your home within San Antonio house buying Facebook pages. You never know, you may have friends or acquaintances who are looking for a home in the area. Social network posts are free and are likely to reach people who are in the same demographic as you are, giving you a fair chance of landing inquiries from prospective buyers who you already know.
Take photos of your home for posting online. Other homeowners hire professional photographers to ensure magazine-worthy images but if you do not want to spend a few hundred dollars on marketing alone, you can try taking photos yourself. Use a high resolution compact or a DSLR to get professional-looking shots. Open up the windows to get as much light as possible, and shoot close-ups of interesting parts, such as hand-carved molding or the texture of a gorgeous brick fireplace, to give interested persons a chance to see the details of the home. With great photos you can inspire prospective buyers to go and see, and possibly buy the property you are selling.


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Friday, November 27, 2009
Akshay Kumar De Dana Dan screening
Moist eyed Bollywood says 26 11 taught unity to Mumbai
Get well soon Akshay Kumar tells Katrina Kaif
New Delhi, Nov 25 (IANS) Bollywood actress Katrina Kaif is down with jaundice and missing from the promotions for her latest outing "De Dana Dan". And her co-star Akshay Kumar was prompt in wishing her speedy recovery.
Rumours were rife that the actress was rushed to Lilavati Hospital in Mumbai Monday night, where she was diagnosed with jaundice and has been advised complete bed rest for a while.
Asked if it were true, Akshay said: "Katrina is down with jaundice... We are missing her and hope she gets well soon."
Apparently "De Dana Dan" is Akshay and Katrina's sixth outing together after movies like "Hum Ko Deewana Kar Gaye" and back to back hits like "Namastey London", "Welcome" and "Singh Is Kinng". They also starred recently in underwater thriller "Blue".
Akshay, who has had a string of flops this year with "Chandni Chowk To China", "8x10 Tasveer", "Kambakkht Ishq" and "Blue", is now keeping his fingers crossed for "De Dana Dan".
"Our chemistry does work and we've seen the results in 'Singh Is Kinng' and other films and we expect the same from this film too. This movie should do very well and I expect great returns for my producers. I have great expectations from this one," he said.
Akshay was here at the DT Cinema multiplex in Vasant Kunj to promote the movie with his co-stars Suniel Shetty, Neha Dhupia, Sameera Reddy and producer Sunil. A. Lulla.
Directed by Priyadarshan, "De Dana Dan" has also been produced by Ganesh and Girish Jain. It also stars Paresh Rawal in an important role.
Akshay and Katrina lovemaking song sequence
Thursday, November 26, 2009
Akshay Kumar promote Film De Dana Dan
Wednesday, November 25, 2009
I ll be there to guide any damsel in distress Akshay Kumar
By Joginder Tuteja
Mumbai, Nov 23 (IANS) He worked with them when they were new to the film industry and gave back-to-back hits but Akshay Kumar refuses to take credit for Katrina Kaif and Priyanka Chopra's success. The actor says he will always lend a helping hand to newcomers if they need it.
"I am extremely happy to be their (Katrina and Priyanka) mentors but then they are free agents. They owe nothing to any one. They got where they are because they are talented. I saw it in them and that's why I wanted to work with them. I am no guru," Akshay told IANS in an interview.
"I don't make it a hobby to help heroines. I wait and I watch and I will of course be there to guide any damsel in distress. However, a 'Katrina' doesn't walk by a film set everyday. They are one in a million for a reason," the star said.
Together, Akshay and Katrina have given super hits like "Singh Is Kinng" and "Welcome". While "Namastey London" was also successful, their first film together "Hum Ko Deewana Kar Gaye" was a decent box office grosser.
On the other hand Akshay has a cent percent success rate with Priyanka as well with hits like "Mujhse Shaadi Karogi", "Waqt - Race Against Time", "Aitraaz" and "Andaaz".
The latest Akshay and Katrina starrer "De Dana Dan" is now ready to hit the screens. The actress has time and again said that she consented to act in a film by Priyadarshan mainly due to Akshay.
"Yes, I know about that. 'De Dana Dan' isn't going to better her career. But yes, it is just good for her to work in different environments. A movie like this is a first for her. She still needs to touch every aspect of her audience and she knows it," said Akshay.
"I know when Katrina says she's doing it for me, it means she respects me enough to say yes to something without question. There aren't any questions around the script etc... It's a plain and simple talk of 'Yes Akshay, when do you need me?'."
Both Katrina and Priyanka have given hits with other actors too. In 2009, Priyanka teamed up with Shahid Kapoor in the successful dark thriller "Kaminey".
Katrina, on the other hand, was seen with John Abraham in "New York". Directed by Kabir Khan, the film was a huge hit. And recently she teamed up with Ranbir Kapoor in the successful romantic comedy "Ajab Prem Ki Ghazab Kahani".
But now she is back with Akshay in "De Dana Dan".
"In any case, the year wouldn't be complete without me chasing after her (Katrina) in one of my movies," Akshay said jokingly.
Farah Khan is the strongest woman in Bollywood Akshay Kumar
New Delhi, Nov 22 (IANS) Guess who's got actor Akshay Kumar's vote as the "strongest" and most "capable" woman in Bollywood? It's none other than the director of his upcoming film "Tees Maar Khan" - Farah Khan.
"Farah is the strongest and most capable woman in the business (Bollywood)... She is highly respected by well-known people (here)," Akshay said in a statement.
"Tees Maar Khan" is a co-production between Farah and her husband Shirish Kunder's production company Three's Company Pvt. Ltd and Akshya's Hari Om Productions.
"I'm sure Farah will make sure we live up to the title and make this film larger than life," said Akshay.
Penned by Kunder, the film was written with Akshay in mind.


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SAN FRANCISCO (CBS.MW) -- Life just got a little easier for foreign nationals when it comes to sending money home.
Yahoo YHOO announced the launch of PayDirect International, which allows users to transfer money to 182 countries around the world.
A bank account isn't needed, nor is Internet access. Instead, the recipient gets a Yahoo PayDirect World Card, which is delivered within five to seven days. That card has a "stored value" and can be used at any of the 800,000-plus Cirrus ATMs worldwide. The sender can refill the same card, up to specified amounts, at any time. The recipient can collect the funds within minutes via MoneyGram's 60,000 international money transfer locations.
Partners involved in offering the service include banking group HSBC, DHL Worldwide Express, payments processor EFunds and Verso Technologies.
IPod in demand
Online music pirates may still be thriving, but that doesn't mean legit efforts aren't gaining traction.
Demand for the IPod is outpacing supply to such an extent that Apple's
Most stores in New York have sold out of the larger capacity models, reported FT.com, and they don't expect to get more before the holidays. Join the "AAPL" discussion.
Bored hackers on buying bender
Three German teenagers took the holiday shopping spirit to a new level, spending about $160 million in just a couple of hours on everything from airplanes to restaurants to artwork.
There was only one problem, however. The suspected 19-year-old perps had to resort to fraud in making the purchases, hacking into an Internet auction account, authorities told Reuters.
"They gave boredom as the motive and made no attempt to disguise what fun they had buying only the most expensive things," according to police in the western town of Limburg.


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Our LWB Bugeye project is coming along nicely, with paint complete in lovely Olde English White, per the original. Next we build the interior, and replace all the trim, restoring each piece as we proceed.
I drove the car back from the paint shop on a wonderful winding road and it drives great, almost identical to a conventional Bugeye but just a tad more stable. If you are unfamilar, we added five inches in the middle of this car, for extra large drivers, or for people who have dexterity, mobility or stiffness challenges. The result is a custom Bugeye, five inches longer than stock.
You'll notice in the last photo that in this car with the seat in the right place for my 5'8″ frame I have about five inches between the lower seatback and the rear bulkhead. This is the greatest benefit of our LWB design… the seat can now go a full five inches further aft than on conventional Bugeyes, thereby accommodating a larger range of body types. I have seen custom Bugeyes with the rear deck cut out to make the cockpit longer, but in this case the seat can still only go as far aft as the rear bulkhead allows. In the case of our LWB car, we have lengthened the middle of the car, so the visual look and feel of the back of the car did not change, and the seat can go further aft to give the occupants five inches more legroom.
Fly first class in this Bugeye!


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Below are a few documentaries that are a must watch if you haven't already seen them. If you have, watch them again.
Congress: Trading Stock on Inside Information
CNN Special Report on the Dot-Com Bubble
Argentina's Financial Collapse
The Crash of 1929: The Great Depression
First Look Inside the Federal Reserve
Black Monday-Nightly Business Report October 19th, 1987
Before the Crash- Wall Street Week October 16, 1987


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|Collection 1999 FallWinter
|Collection Category None
|Movement Quartz
|Packaging Standard
|Water Proof Meter 3
|Artist Pierre et Gilles
|Color Blue
|Strap Color Blue
|Strap material Plastic Folio
|Strap Clasp Material Plastic
|Strap Buckle Buckle
|Dial Color Blue
|Case Color Blue
|Case Shape Round
|Case Material Plastic
|Case Size Medium
|Watch warranty 24 months international warranty
|Width(mm) 34.00 Thickness(mm) : 8.75 Height(mm) : 39.20
The glamorous duo Pierre et Gilles (Pierre Commoy and Gilles Blanchard) have worked in Paris since 1976, directing the stream of contemporary photography towards magical realms through the influence of their baroque, voluptuous, intelligent pop images. The siren song of this sun-drenched Swatch is truly irresistible. Sea-blue stripes promenade down the sand-coloured strap, reiterating the costume of the sailor who, alongside a golden-tressed mermaid, poses alluringly amid sea-spray and sunshine in the centre of the dial. Sexy and salty as the French duo's popular photography, the compass-framed design by Pierre et Gilles is inked with a photograph that has been hand-painted and retouched, in the artists' signature method of combining painting with photography. All in all, La Sirène et le Marin (GZ161) is a magical piece, a memento for collectors of seashells, art, and fashion watches all. The work was commissioned to celebrate the post-renovation re-opening of the Centre Georges Pompidou in 2000.
Battery Change
Set the Date
Set the Time


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- Chelsea, Arsenal and Tottenham to send scouts to watch Athletic Bilbao's Gorka Guruzeta.
- His contract with the La Liga side expires at the end of the 2017/18 campaign.
- READ MORE: Chelsea legend set to retire at the end of the season.
Chelsea are among several Premier League sides sending scouts to watch Athletic Bilbao starlet Gorka Guruzeta in action against Manchester United U23s on Wednesday, according to The Sun.
The Sun report that Guruzeta's contact with Athletic is due to expire at the end of the 2017/18 campaign, which appears to have alerted several of the Premier League's biggest names.
It is mentioned in the report that Chelsea will face competition from Tottenham and Arsenal in the race to secure Guruzeta's services. You'd like to think that we have the appeal and financial resources to brush aside the both of them.
Who is Guruzeta?
Guruzeta is yet to make his senior debut for Athletic, despite now being 21-years-old. He has spent his career so far playing for the B team, who he will be representing vs Man United on Wednesday.
Knowing the club's recent strategy in the transfer market, Guruzeta probably would never make an appearance for the senior side if he joined. Rather he would be shipped out on loan, developed and sold for a healthy profit.


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Submit your support inquiries via the DevExpress Support Center for assistance.
Developer Express Inc is proud to announce the immediate availability of its newest release, DevExpress v20.1. Built and optimized for desktop, web, and mobile developers alike...
With 40 categories and over 400 products to choose from, DevExpress is honored to have been voted best in class 18 times in this year's Visual Studio Magazine Reader's Choice Awards...
Last week, John and I organised the first of a series of meetups. This one was in The Colour Kitchen Oudegracht in Utrecht, The Netherlands.
There was a lot of interest and we had a full Colour Kitchen. I started with a short welcome presentation where I talked about some of the v17.2 release highlights. After that, we had some interesting conversations about pretty much all of our tools and products.
Below is an impression of the meetup
We hope to see you on one of the future meetups!
to post comments.


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Further education colleges are suffering from severe skills shortages because qualified lecturers are being lured into better paid jobs in industry and schools, a national survey has found.
The problems are most acute in the teaching and use of information technology, where further education is aiming to make big strides into contributing more to lifelong learning.
The Further Education National Training Organisation conducted a survey of 142 colleges across the United Kingdom. It found that nearly two-thirds of colleges reported difficulties recruiting IT lecturers. More than a third said they faced a "substantial problem".
More than half of colleges said their lecturers lacked skills in using IT in the curriculum, and nearly half identified skills gaps among their lecturers in teaching online. More than a third of colleges had lecturers who were not even proficient in IT for personal use. Providing help online was also the biggest problem among learning support staff, affecting a third of colleges.
The survey found that qualified lecturers were in short supply in other fields, such as engineering, construction, accounting and science. Two out of five colleges had problems recruiting course and programme leaders - usually the first promotion for lecturers.
Competition for workers from industry and schools was regularly cited by colleges as the main reason for unfilled staff vacancies and, in the case of IT, posts being filled by less able candidates.
A report on the findings says: "Colleges are clear in their belief that the inability to pay attractive salaries and the competition that arises out of alternative employment opportunities are the main reasons for recruitment difficulties."
After curriculum changes introduced last year, there has been especially intense competition between schools and colleges for key skills and IT teachers.
The report warns: "The level of IT and ILT skills gaps reported for lecturers gives major cause for concern. There must be grave doubts about the sector's ability to make a sufficient contribution to effective and efficient growth of IT literacy and the wider use of ILT in the UK."
Geoff Terry, Fento's chief executive, said that the extra Pounds 50 million earmarked by the government last year to boost lecturers' salaries and to fund more professional training would need to be focused on skills shortage areas identified in the survey to have a real impact.
The report suggests that a national promotional campaign to raise the image of further education as a good employer is needed. It also seeks improved pay and conditions for college staff and calls for more cooperative regional training initiatives and secondments for staff to and from industry.
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Kerry Thomas:
Freelance website designer in Derbyshire
Hello, obviously you have come to this to find out all about my lovely self (or maybe you're just really bored). I'm a freelance website designer and graphic designer based in Derbyshire.
Originally I come from Essex, but please don't hold it against me. I've lived in Derby in Derbyshire for the last nine years so I like to think I'm now a fully-fledged duck.
My aim is to help busy business owners and freelancers update their websites to attract more of their ideal clients and leave the right impression.
Contact info
Working hours
What led me here.
When looking back you can see the little breadcrumbs you followed to lead you where you are now, even though at the time the journey seems a lot more… chaotic.
I was never someone who really knew what they wanted to do and I tried quite a few different things before I settled on being a badass website designer.
Along the way I learned quite a few things about myself and the world:
- I'm a dedicated individual for taking on the Yorkshire Three Peaks Challenge and walking 24 miles in 12 hours and on blistered throbbing feet.
- Above all else, I value respect, kindness and honesty and will always provide and expect this from my clients and my friends.
- Other people will hate that you don't like cheese and often try to get you to try it.
- It's important to unwind, you can't work and be available 24/7 (although your website can!)
- I'm a terrible singer but I will always do karaoke when given the chance.
My dad is a programmer and was always trying to guide me and my brothers down the same path, which was clearly quite influential as one of my brothers now is a programmer and he's worked as my back-end developer on a few projects now too! My Dad also bought us Photoshop, and that alongside both my parents and family encouraging my creativity, ignited my interest in design.
Now, I studied Film Production at University and upon exiting I briefly worked in a photography studio (which I'd have loved but it was very high-pressure sales). Next I tried my hand at Telesales which turned out to be one of the better decisions I'd ever made.
At this role, I was given a chance to progress as a marketing assistant, a job that initially focused around email marketing, and it turned out I loved this job. I really have to thank the managers and people that I worked with at this role for mentoring me and helping me to develop my skills and interests. Particularly my boss who even to this day proves a valuable mentor and firm supporter of my career.
So, this started out as email marketing and I got to grips with HTML and CSS responsive email template design, before the role became more about graphic design, marketing, and website management.
My next job was incredibly corporate, which turns out was not quite to my tastes and further away from the work I'd really become to love: website design and front-end development. At this job, I did some bits on the side before taking the leap into freelancing.
And, that's the full story. Or, thereabouts.
Don't forget to add me on LinkedIn so we can stay in touch. Or follow motacilo on social media!


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Cape Town based artist Tia Black released her single Paper earlier in May of this year has recently released her latest single, Going Nowhere. With plans for a full-length album for next year, Ayiba checked in with the twenty-something to find out more about her work and the South African music industry.
How did you break into the South African music industry?
I got my lucky break via Slikour. I was messing about in studio with my producer and he just happened to send through a request for a hook. I laid the hook for "I Got You" in about 7 minutes and we sent it off to him. I was under the impression I was just doing the demo but they decided to keep me on the track.
What do you find most challenging about the industry?
Having to put in ten times what a male does just to get half the recognition. It's frustrating but you also learn to just push through and keep doing what you love.
How would you describe your sound?
I've always said I was an R&B girl at heart. I have, however, dabbled in the pop and trap arena to make things a bit more commercially viable as a vocalist. Right now I'm in more of a rhythmic urban vibe. Frankly I wish I could just use the term "honest" as a genre label.
To what extent do you think your upbringing influenced your career as an artist?
I have been lucky enough to be brought up in a home where I was always told I was a star and the centre of the universe. It created the mentality that I cannot merely just exist because it's not my life path. My upbringing laid the foundation for a great confidence and self-belief that manifests itself in almost everything I do. As a preacher's kid I was brought up in the church and that also helps in keeping me grounded and thankful for the small things but expectant of the major things. In my head I only believe solidly in two things: God and myself.
What projects do you have lined up for the rest of 2017 and 2018?
2017 has been a rough year with car accidents and setbacks due to legalities that are out of my control. Luckily through all of this the year has been great writing wise. The rest of 2017 is for live acoustic sessions and continued writing for artists. I've earmarked 2018 as the year I complete my body of work and not just another EP. I've set out who I would like as producers and majority of the 12 tracks have already been written – Two features and 3 collaborations. Hopefully I can do more TV work as well because I don't only like the sound of my voice I like to watch myself too LOL.
To download "Going Nowhere", visit: http://smarturl.it/TIABlackNow here
Follow Tia in Instagram: https://www.instagram.c om/tiablack007/
Photo Credit: Supplied


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GuildWiki has been locked down: anonymous editing and account creation are disabled. Current registered users are unaffected. Leave any comments on the Community Portal.
Sephis Axe
|Sephis Axe
|Weapon details
Description[edit | edit source]
The Sephis Axe is an axe with a very distinctive looking oblong head. It is one of the largest axes in the game.
Location[edit | edit source]
Sephis Axes drop from Undead and chests associated with them.
- Pre-Searing Ascalon
- Raging Cadaver
- Restless Corpse
- Multiple areas
- Kryta
- Southern Shiverpeaks
- Ring of Fire Islands
- The Desolation
- Dungeons
Dye[edit | edit source]
The axe's grip will change to the dye color.
Notes[edit | edit source]
- Other axes with this appearance:
- Previously, max-damage versions of this axe were very hard to find, making them much sought after. However, since the introduction of Hard Mode and also, GW:EN, which features multiple areas with high-level Undead monsters that can drop this axe, they are now rather common.


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Don't Pressure, EMPOWER!
About us
OwnItNYC is a collaborative effort of New York professionals who wanted to turn around the table of work pressure into empowerment. We enjoy our work so much, and we believe that everyone who works like us should also feel the same.
Our Mission
To set a realization point that the work output of an employee under pressure and an empowered employee are different. To further push employee empowerment through this blog by publishing studies if how an empowered employee performs. To make businesses realize that they have this responsibility of continually empowering their employees, not just in NYC but across the globe.
Our Vision
An empowered workforce is what we dream of seeing. A kind of workforce who can work with grace under pressure because they are well empowered; they feel oneness in the work and happiness of achieving company and team goals. We dream of corporations empowering their workforce not just by injecting loads of know-hows but by thinking creatively on how to empower their employees with out-of-the-box ideas.


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The El Dorado County Sheriff's Office is conducting this recruitment to establish a list to fill current and future vacancies in the Sheriff's Office in Placerville and South Lake Tahoe.
Those applicants who meet the minimum requirements for this position will be required to complete a pre-background investigation questionnaire. Based on the information provided, applicants may be disqualified based on criteria set forth in Part 4, Section 406.1 of the County of El Dorado Personnel Rules.
The eligibility list will be ranked using the following method:
Oral Examination: The oral interview score will be worth 100% of the total score and ranking on list.
Under general supervision, performs a wide variety of peace officer duties involving the protection of life and property, enforcement of laws and ordinances, criminal investigation, crime prevention and suppression, case preparation and testimony, and providing information and assistance to the public.
Deputy Sheriff II is the experienced class in this series, fully competent to perform a wide range of peace officer duties. It is distinguished form Sheriff's Sergeant in that the latter supervises and trains deputies, in addition to participating in law enforcement activities.
Examples of Essential Functions
Patrols assigned areas to ensure the security of life and property, observe situations and deter crime by providing high visibility.
Responds to suspicious activities and answers emergency calls for service.
Enforces state and local laws and ordinances; issues verbal warnings and citations; pursues and apprehends suspects and requests assistance as required.
Investigates juvenile and adult criminal activity and incidents as the assigned detective.
Coordinates crime scene control and investigation, including interviews and interrogations, identification of witnesses, overseeing collection and preservation of physical evidence.
Restores order, protects life and property, and maintains the peace at public gatherings and in conflict situations.
Prepares and documents cases, completes reports and records, and prepares and maintains other logs and records.
Transports criminals to the Courts, hospitals and various other locations.
Serves as bailiff, maintaining order and security in assigned courts.
Serves civil papers to County residents; researches and locates person to be served; provides Coroner/Public Administrator services as assigned.
Serves as a coordinator or team member in such special projects as drug enforcement, livestock investigations and boating regulation enforcement.
Provides traffic and crowd control as necessary; participates in special details and assignments, including K-9 and Search and Rescue; may serve as field training officer.
Retrieves, identifies and returns found property and/or evidence to owners.
Provides emergency aid and assistance to incapacitated persons and requests additional response.
Provides information, directions and other services and assistance to the public.
Coordinates with and serves as back up to other local law enforcement agencies.
Performs other duties as assigned,
Education & Experience Requirements (typing "See Resume" in application will not be accepted)
Where college degrees and/or college course credits are required, degrees and college units must be obtained from an accredited college or university. Courses from non-accredited institutions will not be evaluated for this requirement.
Level II: Must be currently enrolled or have successfully completed a California P.O.S.T. Basic Law Enforcement Academy and possess a current California P.O.S.T Academy Certificate.
NOTE: The above qualifications are typically accepted way of obtaining the required knowledge and skills.
Other Requirements
Must possess a valid driver's license. Pursuant to Government Code, Section 1031, must be at least 21 years of age and possess a high school diploma or have proof of passing the general education development test (GED). Must be willing to work evening, nights, weekends and holiday shifts. Must be able to maintain a firearms qualification.


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Sale price
Regular price
From the Paramount Star Trek Warehouse comes this Medium Ceramic Square Plate that was used as a set dressing piece in Star Trek: Enterprise in many of the galley scenes.These Plates are seen throughout the series in shots from the Galley. The plate measures 5" long and 5" wide. They are made of ceramic.This would make a great piece to any Enterprise or Star Trek Prop collection. We will furnish a Certificate of Authenticity from WilliamShatner.com stating that the piece was used as set dressing piece for use in the Star Trek: Enterprise and obtained from the Paramount Pictures Warehouse.
Each plate will be marked by our Authenticated By Crypto process guaranteeing their authenticity forever.
We have a small number of these plates left in stock.


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"Connecting paddlers through safe and fun group events"
Date(s): Sunday, May 19, 2019
Leader: Al Pilgrim
Co-Leader: Steve Sinderson
Location: Libertyville,IL (Marathon) Wheeling, IL (Minithon)
Skill Level: Advanced Beginner
Category: Paddling Event
Details: This is a listing-only event for PSC points. All information for the Marathon can be found at: www.canoemarathon.com. To receive club points for this trip you must register for this PSC event and also be registered for the Marathon at www.canoemarathon.com. Upon completion of this event we will cross-reference PSC sign-up with Marathon finish results.


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Centers of Excellence
Featured Services
A-Z Index
See full list of Medical Services
291 Port Washington Blvd. | Port Washington, NY 11050 MAP
For information and tickets, please call Christina Boutsikakis at 718-283-7733
Kosher Meal provided by Kosher Thyme, Plainview, NY.
For more information: Christina Boutsikakis | 718.283.7733 | email@example.com
For information on charitable organizations call the New York State Attorney General's Charitable Bureau at 518-776-2160 or go to www.CharitiesNYS.com.
4802 Tenth Avenue
Brooklyn, NY 11219
Appointments: 718-283-2665
General: 718-283-6000


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Synonyms for theurgic
SWAP theurgic IN A SENTENCE
Join our early testers! See how your sentence looks with different synonyms.
Prospero is the type of the Theurgic, as Comus is of the Goetic, magician.
In the process it changed from a philosophy to a system of theurgic practice.
Necromantic magic is divided into Goëtic, maleficent, and theurgic.
Related to this emotional phase of the religious sentiment is the theurgic power of certain natural objects over some persons.
The magical mirror, having lost its theurgic enchantment, finally was placed among the curiosities of the late Earl of Oxford.
Alexandria was the home of many systems of theurgic magic, and gnostic gems afford evidence of the nature of their symbols.
In order to justify superstition and the ancient cults, philosophy in Iamblichus becomes a theurgic, mysteriosophy, spiritualism.
Apollonius defends himself about working miracles and lets a doubt appear about his theurgic powers.
A man therefore can act on demons and control spirits by theurgic rites.


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TV Series Crisis in Six Scenes Seasons 1,2 All Episodes for Download
Crisis in Six Scenes seasons list:
Looking for the Crisis in Six Scenes TV Show? Seasons 1,2 are available for downloading in good and high hd quality, select the season number below.
Crisis in Six Scenes screencaps
Sid Munzinger is a grumpy old man from the new York suburbs, with traditional health problems for his age and rejection of the rapid life of immoral modern youth. Sid seems that if you do not notice the political and social changes taking place around the established realities of life, they will not be able to affect his comfortable world of the past. Previously, he was engaged in the creation of advertising slogans and seriously succeeded in this, and now he is going to publish his own book of small plays and stories. Conservative husband who supports his wife Kay, the same boring old lady. But one day to the spouses Munzinger comes assertive, brisk girl lenny. They are forced to shelter a noisy activist, an ardent human rights activist and, it seems, a fugitive criminal, at home, because they owe lenny's parents a service. The main characters of the series "the Crisis in six scenes" expect to survive she throws herself at the first opportunity, but quickly feels her young enthusiasm and even begin to respect the brave Che Guevara for open beliefs. And so much so that the elderly "revolutionaries" are encouraged to plan the escape of their new friend from the country to free Cuba, where she will be able to revive the bold ideas of Castro.
Televison show Crisis in Six Scenes seasons available for download - 1,21 seasons
Crisis in Six Scenes Season 16 EpisodesDownload


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We hope you've had a chance to test out WebPreserver's awesome features and functionality. Based on feedback from users we have added three new functions.
1. MHTML - Fully browsable screen captures
It's one thing to get a PDF. By popular demand, WebPreserver now also offers an entirely browsable Snapshot of the captured web page or post. That means you can view a WebPreserver capture in your web browser just like it was when you initially preserved it!
2. Web Data Collection Reports
Do you want the facts and just the facts? With WebPreserver's new forensic report, you get a quick and clear presentation of all the web data collected. Download an example below.
Download a Sample Collection Report
3. Enhanced eDiscovery Export
To make integrating and data forensics with eDiscovery tools even better, we now added additional file Metadata, Digital signature & hash information in our EDRM-XML and Concordance DAT file export.


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Sports News of Saturday, 15 February 2020
Source: Ghana Soccernet
Legon Cities FC coach Goran Barjaktarevic has bemoaned his side's failure to pick maximum points against Great Olympics, claiming they were denied a clear penalty in the match.
Legon Cities FC aim of returning to winning ways were given a huge boost when striker Pedro Yakubu Mohammed fetched them opener on the 20th minute mark.
But the Royals were dealt a blow following Ibrahim Sulley's 36th minute equalizer.
In the 88th minute of the game, Legon Cities thought they had found the winner Jabila Abdul Karim went past five Olympics players before being brought down in the penalty box by goalkeeper Ernest Sowah but the referee Rustum Senorgbe waved off their shout as the match ended 1-1.
During his post-match presser, coach Barjaktarevic said his side could have won the encounter had it not been bad officiating.
"I only asked the referee how he saw the penalty decision and he explained to me. No problem. It's part of the game. We will move on. I'm just disappointed we didn't score and win the game."
The result left both Legon Cities and Olympics on 11 points apiece as they occupy 12 and 11 spots respectively.
Send your news stories to and features to . Chat with us via WhatsApp on +233 55 2699 625.


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Back in February 2011, Danny Boyle's production of Nick Dear's drama Frankenstein at the National Theatre was one of the hottest tickets on the London stage. While there's no doubt that the involvement of the 28 Days Later and Slumdog ...Read More »
Making a Monster: Frankenstein
Stories of mad scientists date back much longer than most would think, and well beyond anything approaching modern science as we know it. Every culture has told tales of people creating life from something previously inanimate. In Hebrew folklore, one ...Read More »
Episode 46: Bride of Frankenstein (1935)
On episode 46 of Captive Eye, David Kleiler, Jean-Paul Ouellette and Steve Head consider the enduring qualities of James Whale's Bride of Frankenstein (1935), and bring to light some rarely talked about stories from its making and original release.Read More »
Episode 2: It Comes To Life!
Episode 2 "IT COMES TO LIFE!" The Sound Of Fear continues its journey through the history of horror film music, looking at the age of Universal PIctures and its monsters. Episode Credits: Narrated by Lisa Brigden Written, Produced, and Directed by ...Read More »
"Too dreadfully brutal": In Conversation with author Jon Towlson
"The type of picture that brought about censorship." Review of Mad Love, Motion Picture Herald, 1935 "Quite the most unpleasant picture I have ever seen […] it exploited cruelty for cruelty's sake." Review of The Raven, London Daily Telegraph, 1935. ...Read More »
Dracula vs Frankenstein (US Blu-Ray Review)
Back in the early 80s, when I was in Junior High, there was a Boston institution called The Creature Double Feature—a Saturday afternoon double feature of classic horror films, on a local TV channel, through which many a young person ...Read More »
Episode 12: Transplant Terror: From Mad Love to Mansion of the Doomed
Kat and Samm return for episode 12 of Daughters of Darkness, where they discuss mad science in general and transplant-themed horror in particular. They begin with an analysis of the origins of mad science fiction in Gothic literature — partly ...Read More »
200 Years of Filthy Creation: Mary Shelley, Horror's Greatest Mother
Two hundred years ago this week, history was made with the birth of that filthiest creation of all, Frankenstein: one of the most influential Gothic and science fiction novels of all time; a book that inspired countless generations of writers, ...Read More »
Hammer Horror Classics on Blu-Ray
Last year, Diabolique Magazine, in conjunction with dvddrive-in.com coordinated an online petition to ask Warner Bros to release their classic Hammer Horror titles on blu-ray. Yesterday, the official announcement was finally made, and the initial set of titles is scheduled for ...Read More »
Bruce Hallenbeck remembers Sir Christopher Lee
I first encountered Christopher Lee shortly before my sixth birthday, in a darkened movie theatre where HORROR OF DRACULA was unspooling onscreen before my startled, innocent eyes. Even at that tender age, I had seen Bela Lugosi as Dracula on ...Read More »


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It wouldn't be Christmas without lights on Main Street, cookies for Santa, packages from Amazon. And what's Christmas without year-end tax legislation? Never to disappoint, Congress passed and President Obama signed into law the Tax Increase Prevention Act (TIPA) on December 19.
For the most part TIPA is nothing new, and in fact the "extenders" as they are known in the legislation apply to tax deductions you may not have even realized had expired at the end of 2013, but now are retroactively renewed for 2014. There were about 50 of them; I'll hit the most reader relevant ones here.
Good news for teachers. You can continue to deduct the first $250 of expenses directly on your tax return without having to clear the 2% hurdle on your miscellaneous itemized deductions. At a 25% tax rate that's a savings of $62.50.
For taxpayers who either live in a state without an income tax, or pay little or no state income tax whether due to low income or non-taxable income (such as pension income), the alternative deduction for sales has been helpful and was renewed for 2014. For most taxpayers using this method, it provides for the deduction of either an allowance for sales tax based on income, or actual sales tax paid during the year. For the allowance method, you can add actual sales tax paid for purchase of a motor vehicle, boat, aircraft, or construction of a home or home addition (with some restrictions). For a married couple with income between $30,000 and $40,000 with no special purchases, the deduction allowance is $488. Not tremendous, but likely to yield $60 or so in tax savings for those in the 15% bracket.
The mortgage insurance premium (PMI) deduction was also extended for 2014. For someone paying $100 a month in PMI in the 25% bracket, that's a savings of $300 for the year.
In the big savings category, it's good to see the exemption from tax of personal residence debt forgiveness be continued, at least for 2014. Without that extension, folks who sold their home in a short sale this year would have been hit with a hefty tax bill; adding insult to injury. Let's say a home sold in a short sale for $100,000 but you owed $140,000. Had the legislation not been signed, that $40,000 forgiven would be taxed as income. For an average taxpayer in the 15% bracket, that's a tax bill of $6,000. It's also quite possible the $40,000 would lift the marginal tax rate to 25%, meaning part of the income would be taxed at the higher rate and yield an even bigger bill. Readers who either took the gamble and sold short in 2014 or had no choice for the timing can breathe a sigh of relief.
Taxpayers with kids in college who are not eligible for the American Opportunity Tax Credit often can still qualify for the $4,000 tuition deduction. That's another deduction extended in TIPA.
If your employer offers a transit benefit plan, where you can receive tax free reimbursement of qualified commuting costs (parking and mass transit), you likely noticed the monthly reimbursement limit dropped from $245 to $130 for transit in January, while the $245 parking limit went up to $250. TIPA raised that $130 for transit up to $250, retroactively. That means if you ran all of your commuting costs through payroll deduction, including the amounts that were not reimbursed, you will receive a retroactive reimbursement. Since again we do not know if this will be extended into 2015, it is smart to continue (or start) to run all costs through the program in case there is another retroactive extension in 2015.
So far we've looked at extensions that really are too late to plan around; they will be an extra bonus if you qualify. But there still are a few days left to take advantage of at least two provisions: the IRA charitable rollover and energy efficient savings.
For those looking to do year end giving and have IRA funds available to do it with, the IRA charitable rollover can save steps and money. This allows you to make a donation of up to $100,000 from your IRA directly to a charity. It's only for taxpayers over age 70 ½. Making a donation this way can satisfy your required minimum distribution, and also avoids adding income on your tax return, which can have an adverse effect on the taxation of Social Security benefits and the minimum you must reach before deducting medical expenses or miscellaneous itemized deductions, not to mention taxpayers who don't normally itemize may miss out on the charitable deduction entirely.
Did you get a Home Depot gift card for Christmas? Might want to use it for insulation or a new energy efficient door. The residential energy tax credit was also extended through 2014, for items such as windows, insulation, doors, central air, heat pumps, furnaces, and water heaters. For windows, insulation, and doors the credit is limited to 10% of the cost excluding labor (with a maximum of $200 for the portion that is windows), and just $150 for central air, heat pumps, furnaces, and water heaters. But wait- after all of that, you have a lifetime limit of $500 in credits cumulative from 2006 forward. If you claimed that much already in prior years, you're out of luck for this year.
Now for something completely different: the TIPA legislation also created a tax benefit. The ABLE Program, or Achieving a Better Life Experience, is a long overdue benefit for families of the disabled. It allows families to save a child's Social Security funds in an account similar to a 529 college savings account that can be used tax free for qualified expenses later, without jeopardizing benefits now. The plight of special needs families navigating the financial system is deserving of a separate article.
What does all of this mean for planning in 2015? Not a whole lot at this point, unfortunately. There is talk-again- of permanent reform and long term extensions, but pardon my cynicism; I'll believe that when I see it.


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In Harry Potter and the Deathly Hallows Part 2, Griphook the Goblin helped Harry Potter break into Bellatrix Lestrange's vault at Gringott's Bank to steal the cup of Helga Hufflepuff.
Based on his appearance in the film, Star Ace Toys are excited to add Griphook the Goblin to their 1/6th scale line of Harry Potter action figures. Griphook stands at approximately 7.5" tall and features the authentic likeness of actor Warwick Davis as Griphook from Harry Potter and the Deathly Hallows Part 2, with a specially hand-painted head sculpt, film-accurate expression and detailed skin texture. Griphook Also comes with multiple accessories, including the Sword of Gryffindor, Helga Hufflepuff's cup, and the bank clanker he used to get by the dragon guarding the vaults.
Official Harry Potter licensed merchandise
If for any reason you are not 100% happy with your purchase, we can provide you with a full refund or exchange if you return it to us within 7 days after you receive the goods. Conditions apply, please see our terms and conditions.


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KELOWNA - Residents of more than 100 properties in Joe Rich can return home today, despite the 465 hectare fire being only 20 per cent contained.
The wildfire burning east of Kelowna forced more than 1,100 people from their homes Friday, however crews have managed to keep all threatened properties safe.
On Sunday, the Central Okanagan Emergency Operations Centre lifted an evacuation order for 263 properties, and about 600 residents were allowed to go home. At roughly 11:30 a.m., Aug. 28, evacuation orders were lifted for 120 more.
Those properties on Goudie Road, Peregrine Road and Sun Valley Road are now on evacuation alert and residents should be prepared to leave again at a moments notice.
For an updated, interactive map of the revised evacuation order and alert areas, visit the Regional District emergency website.
The evacuation order remains in effect for 160 properties and 380 residents.
About 90 firefighters along with two dozen trucks and water tenders are battling the blaze today, Aug. 28.
Emergency Operations says other than household pets, like cats and dogs, animals are not allowed back in at this time, due to the uncertainty about fire behaviour and the potential for Evacuation Orders to be re-instated if necessary.
Residents on the Falcon Ridge water system are restricted to household use only – no irrigation permitted to preserve water supply to fight the fire, officials say.
The Emergency Support Services reception centre will be open from 11 a.m. to 5 p.m. today, Aug. 28, at the Willow Park Church along Highway 33 in Kelowna.
Highway 33 remains closed. For the latest information on the closure go to Drive B.C.
The Philpott Road fire was discovered on Thursday, Aug. 24.
To contact a reporter for this story, email Mike McDonald or call 250-819-3723 or email the editor. You can also submit photos, videos or news tips to the newsroom and be entered to win a monthly prize draw.
We welcome your comments and opinions on our stories but play nice. We won't censor or delete comments unless they contain off-topic statements or links, unnecessary vulgarity, false facts, spam or obviously fake profiles. If you have any concerns about what you see in comments, email the editor in the link above.


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Large Amethyst Record Keeper Point
Say hello to your beautiful large Amethyst record keeper crystal point! This natural unheated lavender and purple crystal has numerous indented triangle record keepers that can help you access intuitive information during meditation.
Makes a perfect addition to your crystal collection or as a meaningful decor piece for your home or sacred space. The tip has some natural indentations as seen in the photos. There is also a phantom outline formation from the iron inclusions that grew naturally in the crystal.
The energy of this Amethyst would make a great meditation tool for boosting your third eye and intuition. Place Amethyst in your bedroom to promote calming and relaxation, or use it in a crystal grid for energetic protection and sweet dreams!
4.3" x 3" x 2.2" (10.9cm x 7.6cm x 5.7cm)
Weight: 13.1 oz / 370g
Origin: Brazil
Your beautiful new Amethyst point will arrive carefully gift wrapped and ready to love. Due to the natural material of this crystal point, expect natural textures and/or small natural fissures. Photos taken in natural light, no modifications


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FAQs - Lawsuits
30 Sep 2019
Who Is The Best Car Accident Lawyer In Phoenix, AZ?The best car accident lawyer in Phoenix, AZ is one who is experienced, patient, and willing to fight for your right to recover compensation. The insurance companies will do just about anything to pay you less, so you want a legal team who is willing to stand up and fight for your rights. The team at Zanes
03 Sep 2019
Can I File A Talcum Powder Lawsuit?If you believe there is a link between your cancer and your talcum powder use, Zanes Law will review your case for free. You may be eligible to take legal action, including filing a talcum powder lawsuit. The lawsuits in the pending mass tort against powder manufacturer Johnson & Johnson allege that these
03 Sep 2019
What Is The Talcum Powder Lawsuit?Talcum powder manufacturer Johnson & Johnson faces thousands of lawsuits related to the possibility that its talcum powder products, including Baby Powder and Shower to Shower, may cause an increased risk of mesothelioma and ovarian cancer. With more than 14,000 cases pending as of September 2018, the cou
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You're guaranteed more than just a delicate sip of "tea" (as in the truth, and delicious gossip) when in the company of Lenox Magee, David Dodd, and Isaac King. The Sip, their two-year-old Chicago radio show, which broadcasts and streams on Friday nights from 6-8 P.M. CST on Urban Radio Network, is the country's first of its kind: pop culture and politics from a gay black perspective, with a whole lot of "tea" being served.
"I'm not sure about the measurement of the tea we spill," King muses. "I always hated math, anyway. It's quality tea, and that's what's most important."
Their Previous episodes can be listened to on Mixcloud (www.mixcloud.com/thesip), and a mere sampling of past guests on the show (there's more than enough tea to go around, after all) has included The Chew's Carla Hall, singer Darrian Ford, actress Rutina Wesley of HBO's True Blood and OWN's Queen Sugar, Simone Missick of Netflix's Luke Cage, author James Earl Hardy, the cast of Noah's Arc, and former Destiny's Child member LaTavia Roberson. "That interview got a lot of response," King recalls of the latter. "She became upset about a question Lenox asked her and she hung up after cursing us out!"
Keep reading over at Passport magazine online…


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foreign exchange - How Online Forex Works - FX-GO.com
These articles discuss currency trading as buying and selling currency on the Forex market, trading basics, and tools and techniques. How Forex Works.
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Understanding Foreign Exchange Trading . Menu Search The whole purpose of trading forex online, Find out Which Foreign Exchange/Forex Trading Lot Size Works Best.
How Does Forex Work? How Do You Trade In Forex?
If You Are Interested to trade online, you need to know how does online trading work. In here you will learn the 5 steps required to start online trading.
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Middle Aged and Stuck in Life? - New Prospects on the Horizon
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2011-03-31 · In forex trading, the unit of What is a Pip in Forex? Understand How Your Margin Account Works. What is Margin Trading? What is Balance?
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2010-08-21 · MetaTrader 4 is an electronic trading platform used by tons of forex brokers and forex traders. Introduction to MetaTrader 4. Partner Center Find a Broker.
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How Forex Trading Works. What is the Foreign Exchange Market? What is Forex Trading? How Does Forex Trading Work? The Asset – Currency Pairs; The Value – Forex Quotes
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Choosing a Broker - Before you can trade stocks online, you have to select an online broker. Learn what you need to know to make the best selection as well as how to
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Here's how the Local Trade Copier typically works You just have several MetaTrader accounts on the same computer the one that everyone get from their Forex
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2011-02-17 · Know your forex terms Before we delve any deeper into the possibilities that exist in the Forex market, we need to go over some basic Forex market terms.
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How Does Foreign Exchange Trading Work? often shortened to forex trading, works Understanding the forex market and winning at trading forex online is an


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Online ISSN : 2319-7706
Issues : 12 per year
Publisher : Excellent Publishers
Email : firstname.lastname@example.com / firstname.lastname@example.com
Editor-in-chief: Dr.M.Prakash
Index Copernicus ICV 2018: 95.39
Bacterial multidrug resistanceis a phenomenon that has been growing with increasing speed worldwide. New mechanisms of resistance have been described in different bacterial pathogens, representing a threat to effective treatments of common infectious diseases with currently available drugs. The use of drugs known as "non-antibiotics is among the alternative approaches to the use of conventional antibiotics. This approach has been studied in order to counteract the global threat of multidrug resistance.This group of drugs includes various non-steroidal anti-inflammatory drugs (NSAIDs).The NSAID diclofenac has demonstrated broad-spectrum antimicrobial activity in vitro and in vivo. In addition, this drug has an synergistic antibacterial effect when combined with certain other drugs. It may also show anti-biofilm activity, and may inhibit or decrease the activity of certain virulence factors in some bacterial pathogens.


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SizeUp helps private sector, government, and non-profit organizations better serve their small business customers with the market research and business intelligence they need to succeed. SizeUp empowers our clients to help their small business customers succeed and increase engagement. For private sector customers, it also enables them to introduce products and services to their small business customers at strategic decision making moments in the business' lifecycle, increase acquisition of new customers, and retain existing customers.
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Weekly Round-Up: Atlético win in Belo Horizonte, no goals in São Paulo between Corinthians & Fluminense
Atlético Minero defeated La Equidad, but an away goal for the Colombians has them confident of their chances of turning the tie around next week in Bogotá. David Camacho's early penalty gave La Equidad the lead in Belo Horizonte and a crucial away goal. Atlético Minero would rally though. Jair struck first, smashing home on half an hour to equalize, then Elias in the second half gave Galo the lead for good from distance.
👀⚽ That shot had eyes! Elias helped @atletico_en turn it around tonight against @Equidadfutbol in the #Sudamericana quarterfinals. pic.twitter.com/d1x8yeqodH — CONMEBOL Sudamericana EN (@TheSudamericana) August 21, 2019
While the result is a positive one for the hosts, La Equidad will take confidence from their away goal, returning to Bogtoá with the knowledge that a 1-0 win next week would be enough to send them through to a semifinal matchup with Colón.
In São Paulo, a 0-0 draw between Corinthians and Fluminense leaves it all to play for next week in Rio de Janeiro. Corinthians had the majority of the chances on the night, with the Fluminense goalkeeper making a few impressive saves to keep the match scoreless.
⚽🎥 Watch the highlights from the draw between @Corinthians and @FluminenseFC in the #Sudamericana quarter-finals first leg! pic.twitter.com/stvd2F1d9l — CONMEBOL Sudamericana EN (@TheSudamericana) August 23, 2019
Next week's match will determine who will face off with Independiente del Valle in the other semifinal. Both sides will feel they stand a chance with one moment potentially proving the difference at the Maracanã.


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Home > All celebration cakes. > Formal occasions. > Colours / Pattern / Sunset - Click on the pic for more info
Beautiful Cake in sunset colours
Orange and red - The colours of a beautiful sunset.
This is a fondant iced cake so colours can be changed to any two complementary colours.
Price includes writing a message on the board and up to ten candles. Extra candles can be purchased at the checkout and candles will be matched to the cake.
This cake will keep for 2-3 days from purchased and should not be stored in the fridge.
It can be ordered for delivery on Friday and will keep fresh all weekend.
Requires four days' notice.
All our cakes are made without chemicals and contain no preservatives or colouring in the baking.
We only use free range eggs.
Always buy the best food you can afford. You never regret buying quality.


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Over the past two months The Tech Equestrian has interviewed some of the most innovative equine technology software, apps and products that are on the market or are in pre-launch and discovered a collective voice that is saying: 'Equine tech is here to stay!'
I asked each technology provider, "Where do you think we will be in the next 5 years as it relates to adoption of technology in the equestrian world?"
"While people have been slow to adopt some technologies that are designed to make their equestrian lives easier, they have started to embrace equine focused technology more willingly since they have grown accustomed to technology in other aspects of their lives."
Nicole Lakin, Owner & President
"We must take advantage of everything that technology offers us to improve the quality of life of our horse and improve its performance."
Nick Rolle, Business Partner
"Technology is making things easier and more convenient for horse owners and we are seeing that on so many levels."
Chris Woodside, Co-Founder
"The adoption of technology for the horse world will slowly improve and two key ingredients that will accelerate growth is to develop apps that are easy to use and compatible with other existing products."
Guy Barry, Sales Manager
Horseco"I think the equestrian world is just starting to see the benefits of technology as an enabler; the opportunity is now to create something new and fresh to bring to this world."
Charlie Trietline, CEO
"This is an exciting time for technology in the world of equestrian sports. Trends around wearables and data collection in human athletics are making their way into the equestrian space and as riders become more comfortable with the new technologies, the use of data to improve performance and prevent injury will become more mainstream. Over the next five years we will see the technologies that have transformed other sports have a similar impact among equestrians, as riders adopt new tools to improve the fitness of their horses and look for an edge in competition."
Kate Motley, Co-Founder
"I think that the technology and data level is lower in horse sports than say tennis or soccer however, as part of the JUMPFAX mission our goal is to upgrade the experience by leveraging the analytics of the data."
Cléo Levy, Project Manager
"Given the rapid adoption of technology in everyday life, I feel that the equestrian community will steadily increase adoption of tech tools to help manage their barns and so much more."
Kate Rice Nilan, Founder
Stable Secretary
To view all of the equine tech providers listed here, visit the RESOURCE PAGE on this site.


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Follow @RADscreenings for the latest updates
RAD is Manchesters home of retro, awesome cult movies. We are dedicated to providing the most raddest cinematic experience whilst celebrating some of the most fist pumping, quotable, legendary movie moments with an eclectic programme of double bills, all-dayers and exclusive Q&As!
Next up at RAD:
Spy Kids - 10/09/19
SPY KIDS, the last feature Robert Rodriguez ever shot on film, tells the tale of Carmen and Juni Cortez who must save their parents from danger upon discovering they are secretly ex-spies. The 2001 film, which features stars such as Antonio Banderas, Alan Cumming and Danny Trejo, grossed more than triple its budget at the worldwide box office and resulted in a memorable trilogy.
Join us for a special screening introduced by film journalist and self-proclaimed Spy Kids fanclub president Millicent Thomas, to celebrate the unique creativity of this modern classic.
Doors open at 5:30pm for a 6pm start.
Tickets £5


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barry moxam commented 2018-10-24 18:38:17 -0400
i never heard of this movie before! but then , how could i ,when the marxist mediaignores it as politically incorrect
Unlike the fictional anti-American movies nominated for Oscars this year, Clint Eastwood's new film tells a true story about the real United States, the one I grew up in.
The 15:17 to Paris tells the true story of three heroes (played by themselves) who thwarted a terrorist attack on a train in Europe.
First off, this movie looks great. The 15-minute train attack sequence alone should win an award.
However, The 15:17... does drag a little: They could have cut at least 30 minutes from its two-hour running time.
That said, the movie is unapologetically patriotic and puts the heroes' Christian faith front and center. Watch my review (SPOILER ALERT) to see what I think about it over all.