text: The Speed Wrap Challenge is an exciting, live vehicle wrapping competition. The competition is brought to you by platinum sponsor Roland, vinyl sponsors Grafiwrap distributed by Maizey Plastics), Hexis (distributed by Falcon) and expo sponsors FESPA Africa 2018 and Sign Africa. The first round of the competition will start at 10am every day of the expo from the 12th-14th September. The last round will take place on the 12th and 13th September at 4pm. For the grand finale, the final round will occur at 3.30pm on the 14th September. Come along and watch the industry's wrapping experts compete for the title of champion and become the next champion! You can compete in 3 easy steps: 1. Pre-register at the Speed Wrap stand 2. Your registration will be confirmed with your time slot. Spots are currently limited and it's vital that everyone gets a fair and equal opportunity to compete. Each round will be allocated firstly to anyone who has not competed for the duration of the exhibition and then to competitors who have participated already. 3. Ensure you keep to your time slot and wrap to the best standards. Terms and Conditions Apply - The judge(s) decision will be final and no correspondence or discussion will be tolerated - Prizes are non-transferable and there is no cash alternative. You cannot apply for non-cash prizes in regard to the Grand Prize - All taxes, insurances, transfers, spending money and any additional expenses (including meals or personal expenses) unless specifically stated are the sole responsibility of the prize winner Great Prizes -W-ookie (Wrap Rookie): 1st R3 500 2nd R1 750 3rd R1 000 per day. -Wrap Lord (Professional Wrapper): Score more than 45 points and double your money. - The Grand Prize is a trip to compete at the FESPA World Wrap Masters Final at FESPA Global Print Expo, Munich 2019 including flight and accommodation. The Speed Wrap challenge will occur across all 3 days of the expo. The first round will be at 10am. The final round will take place on Friday 14 September. For more information on the Speed Wrap Challenge visit here


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Her face the sinking stars desire:
Unto her place the slow deeps bring
Shadow of errant winds that wing
O'er sterile gulfs of foam and fire.
Her beauty is the light of pearls.
AII stars and dreams and sunsets die
To make the fluctuant glooms that lie
Around her; and low noonlight swirls
Down ocean's firmamental deep
To weave for who glimmers there
Elusive visions, vague and fair;
And night is as a dreamless sleep:
She has not known the night's unrest
Nor the white curse of clearer day;
The tremors of the tempest play
Like slow delight about her breast.
The berylline pallors of her face
Illume the kingdom of the drowned.
In her the love that none has found,
The unflowering rapture, folded grace,
Await some lover strayed and lone,
Some god misled, who shall not come
Though the decrescent seas lie dumb
And sunken in their wells of stone.
But nevermore of him, perchance,
Her enigmatic musings are,
Whose purpling tresses float afar
In grottoes of the last romance.
Serene, an immanence of fire
She dwells for ever, ocean-thralled,
Soul of the sea's vast emerald.
Her face the sinking stars desire.
Printed from: www.eldritchdark.com/writings/poetry/364
Printed on: October 30, 2020

subset: commoncrawl


text:
Atomic all clock with self-setting time and date, indoor temp, alarm. Please note: Product has ONLY indoor temperature, NOT outdoor temperature.
Automatically updates for seasonal time changes where applicable
Clock with alarm and snooze
time with seconds.Works well with good alkaline AA batteries .
Displays time, date, day, temp on one screen
wall hanging or free standing
Measures 9 by 1 by 7.2 inches
requires 2 AA batteries (not included)
Color : Silver
Size : NO SIZE
View larger
La Crosse Technology WT-8005U - 9 in. Digital Atomic Wall Clock
Digital Style with self-setting time attracts for your convenience and enjoyment. Time display self-sets to the Universal Time automatically, keeping you right on time! On/off optional daylight saving time updates. It features perpetual calendar that displays weekday and also monitors your indoor temperature. Also, features a time alarm with snooze for table side use.
Self Set Atomic Time
Automatic self sets your time to your adjusted US time zone (available ET, CT, PT, & MT) giving you the most accurate time! Adjustable view in standard 12 hour or military 24 hour time.
Accurate indoor room temperature can be viewed in Fahrenheit or Celsius
Display the Day, Date, and Weekday
Wall hang or Stand Alone
Hang onto a wall or place onto a table to use alarm feature. Fold-out leg stands allows to be used onto desk or nightstand.
Alarm with Snooze
5 minute snooze alarm time. Alarm icon shows when it's activated.
- Atomic all clock with self-setting time and date, indoor temp, alarm
- Automatically updates for seasonal time changes where applicable
- Clock with alarm and snooze. Counting seconds display.Works best with good alkaline AA batteries.
- Displays time, date, day, temp on one screen; wall hanging or free standing.
- Measures 8.95L x 1.05W x 7H - 2 Time Digits
- Requires 2 AA batteries (not included)
- IN Temp Range: 14.1 F to 139.8 F (-9.9 C to 59.9 C)


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Searchable classes: concept, author, abstract, title, date, doi and all fields
If you want to search in all fields, just enter your search term, e.g. fever.
If you want to get more specific search results, e.g. search for a MeSH concept, enter: concept:D045169.
A specific doi can be (for example) searched via: doi:10.1101/2020.05.29.20115824
Similarly, you can search for an author entering author:"Max Mustermann"
If you only know the last name, search for author:*Mustermann.
Dates can be in various formats, for example date:2020-05-15 if you are looking for a specific day or date:2020-05 if you want to query for a month.
However, the following expressions will also work:
date:"last tuesday to today"
date:"-1 week to now"
The search query can be based on several classes (e.g. MeSH identifiers, authors, abstracts etc.)
AND, OR and NOT modifiers can be used for concatenation of search queries using the advanced search.
For example: ((abstract:fever) AND concept:D045169) AND title:covid-19
Edema (5)
Abdominal Pain (5)
Cryopyrin-Associated Periodic Syndromes (4)
Mucocutaneous Lymph Node Syndrome (4)
Myocarditis (4)
Abdominal pain (5)
Shock (4)
Pneumonia (4)
age categories (5)
gender (1)
serum sample (2)
Authors: Margaret Cho; Weiguo Liu; Sophie Balzora; Yvelisse Suarez; Deepthi Hoskoppal; Neil D Theise; Wenqing Cao; Suparna A Sarkar
Date: 2020-08-07
Source: medRxiv
Authors: Leila Shahbaznejad; Mohammad Reza Navaifar; Ali Abbaskhanian; Fatemeh Hosseinzadeh; Golnar Rahimzadeh; Mohammad Sadegh Rezai
Date: 2020-07-30
Source: ResearchSquare
Authors: Leila Shahbaznejad; Mohammad Reza Navaifar; Ali Abbaskhanian; Fatemeh Hosseinzadeh; Mohammad Sadegh Rezai
Date: 2020-07-30
Source: ResearchSquare
Date: 2020-07-30
Source: ResearchSquare
Authors: Abdul Rauf; Ajay Vijayan; Shaji Thomas John; Raghuram A Krishnan; Abdul Latheef
Date: 2020-05-15
Source: ResearchSquare
This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.
nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.
Contact | Legal Notice


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Hemp milk: Nutrients, Benefits and Recipe
Hemp milk is a vegetable drink that is obtained from the mixture of ground hemp seeds and water. It can be used as an alternative to cow's milk and is suitable for vegan consumption.
Hemp milk is a drink of high nutritional value, because it contains large amounts of vitamins, amino acids and minerals. It has a silky texture and whitish color. Its flavor reminds of the nut and is slightly bitter so it can be sweetened with sugar or sweeteners.
This drink is an interesting option for those who have lactose intolerance or follow a vegan diet.
Nutritional value of hemp milk
Hemp milk is an ideal supplement for anyone looking to increase the daily intake of proteins, vitamins and minerals. It is composed of hemp seeds, which is the cannabis plant, of legal consumption and strictly regulated.
The proportion of nutrients that it presents is the following:
- High content of essential fatty acids (40%): those fatty acids that the organism cannot synthesize and need to include them from external sources. Its high amount of omega 3, omega 6 and gamma-linolenic acid is especially noteworthy.
- High percentage of vegetable proteins (35%): contains all the essential amino acids in a similar percentage to animal protein sources such as meat, milk or eggs.
- High amount of fiber (6%): beneficial for digestive health.
- High vitamin E content: a powerful natural antioxidant.
- Rich in essential minerals: phosphorus, potassium, iron, zinc and magnesium.
On the contrary, they have a low amount of:
- Carbohydrates (10%).
- Vitamin A, B and C.
- Calcium and manganese.
Benefits of hemp milk
Contains essential vitamins and nutrients
As we have seen in the previous section, hemp milk is rich in essential nutrients for the organism such as phosphorus, magnesium, potassium, iron or zinc. These minerals are important in the process of muscle contraction, the formation of bones and some biochemical processes of the nervous system, among many other things.
On the other hand, vitamin E is an important antioxidant in the field of cardiovascular health.
Regulation of intestinal transit and cholesterol
The high fiber content of the hemp seeds that are used to make this vegetable drink favors the regulation of intestinal transit, preventing problems of constipation.
Also it is possible to emphasize its regulating action of the levels of cholesterol and arterial tension, because the fiber prevents the absorption of the LDL (bad cholesterol).
Contraindications of hemp milk
The interaction of this drink with other compounds can decrease the formation of platelets; therefore, people who have problems related to coagulation or who are taking specific drugs should drink this drink with caution and consult a professional.
In addition, consumed in excess, hemp milk can cause diarrhea, stomach pains and abdominal distension due to its high fiber content.
Hemp milk is very easy to prepare and can stand in good condition for up to three days if stored in a cool, dry place away from direct sunlight. Its method of preparation is similar to other vegetable drinks, such as almond milk or soy milk.
- 150 grams of hemp seeds
- 1 liter of water
- Sugar or natural sweetener: honey, stevia, cinnamon or dates
- a pinch of salt
- Soak the hemp seeds in a liter of water for about two hours.
- Once the time has elapsed, proceed to crush the mixture with the help of a blender. It is recommended to do it by parts, to make sure that a homogeneous mixture results.
- Then strain the resulting drink with a very fine sieve or with a piece of vegetable tissue. The part that remains in the colander can be used to make cookies, bread, muesli or biscuits.
- Add the pinch of salt and sweeten to your liking.
- Place the milk in a bottle and it is ready for consumption.
Hemp milk, like other vegetable drinks, is very versatile and can serve as a base for making smoothies, desserts and sauces. Combining it with fruit, low fat cheese and some whole grain cereal, it constitutes a nutritious and complete breakfast or snack.


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Learn more about the rich biodiversity of Mauritius during this guided hiking adventure!
Throughout this whole hiking tour, you can be sure to enjoy the sounds of nature and the chirping of many tropical birds, to discover breathtaking panoramic views over turquoise lagoons and to encounter many endemic species. Just don't forget your camera, as you are guaranteed to have some picture-perfect moments! The guide will be there to inform you on the many wonders you will encounter, such as the ebony trees, the orchids, the Mauritius Kestrel and, when lucky, a Rusa deer.
|Operating hours
|09.00 – 17.00
|Operating days
|All days
|2 hours
|Activity time
|Offered as supplement
This hike is relatively easy and therefore perfect for both experienced and unexperienced hikers. Everyone can just enjoy the surrounding tranquility during this wonderful outdoor adventure. The park, la Domaine de l'Etoile, used to be a private hunting ground and has therefore always been well maintained and preserved. This provides the park with its uniqueness and beauty, that asks to be explored. At the end of your hike you can enjoy an optional lunch in the ravishing restaurant that can be found in the reserve, which offers stunning views onto the mountain.
Terms and conditions
- The maximum number of participants if 30.
What is included
- Depending on the size of the group, one or two professional guides will accompany you.
- All participants will be provided with 0.5L of water.
- The duration of this excursion may vary, depending on the participants' fitness level.
- Participants are recommended to bring sun cream, mosquito repellent, good walking shoes and a camera. It is also advised to wear long trousers if possible.
Tour Reviews
There are no reviews yet.


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- Quality, Clean Portable Toilets in Oakland, CA
- Standard & Luxury Units Available.
- Delivered Within 24 Hours.
Portable Toilets in Oakland, CA
Cork'd Portable Toilets enables customers to quickly and easily locate the portable toilet in Oakland they have been searching for. If you had to find and price porta potties in Oakland using Yellowpages or various websites before you know how difficult it can be to quickly find information. Thankfully Cork'd Portable Toilets is on your side, helping you easily locate the Oakland portable toilet thats just right for you and just right for your budget.
We carry:
- Standard Portable Toilets in Oakland, CA
- Luxury Portable Toilets in Oakland, CA (More spacious, flushable unit)
- VIP Porta Potties in Oakland, CA (More spacious, flushable unit, sink/mirror)
- Portable Restroom Trailers in Oakland, CA
- ADA Compliant Portable Toilets in Oakland, CA
Portable Toilet Rental Costs in Oakland, CA
Average Cost in Oakland: $171.91
$162.49 - $181.32
Lowest Price Paid
Highest Price Paid
Estimated portable toilet cost in Oakland: $171.91
This cost is based on Alameda County labor costs and includes costs for a standard toilet unit and up to 7 days of use. Oakland portable toilet costs can vary by unit type, service requirements, and delivery distance.
Non-Verified Portable Toilets Companies
Easy Porta Potty Rental Vacaville
418 Elizabeth St
Vacaville, CA 95688
CleanBox Porta Potty Rental
411 William St
Vacaville, CA 95688
Express Portable Toilets Vacaville
479 Mason St Ste 305
Vacaville, CA 95688
Wine Country Sanitary
Sonoma, CA 95476
Allstar Sanitation
Santa Rosa, CA 95407
Royal Flush
Santa Rosa, CA 95407
North Bay Portables
Santa Rosa, CA 95407
Vip Sanitation
Santa Rosa, CA 95405
QuickCan Portable Toilets Santa Rosa
525 4th St
Santa Rosa, CA 95401
CleanBox Porta Potty Rental
416 B St
Santa Rosa, CA 95401
I need to rent 1 porta potties for a holiday party this Tue.
Cullen E.
Piedmont, CA, 94620
Unit Type: Standard
$ 110/unit per week
I need to rent 1 porta potties for a wedding next month.
Kristian T.
Oakland, CA, 94604
Unit Type: Standard
$ 111/unit per week
I need to rent 1 porta potties for a wedding tomorrow.
Danielle D.
Oakland, CA, 94660
Unit Type: Standard
$ 80/unit per week
We need to rent 10 porta potties for a party next month.
Debbie W.
Oakland, CA, 94666
Unit Type: Standard
$ 92/unit per week
We need to rent 2 porta potties for a home renovation next summer.
Clay E.
Oakland, CA, 94622
Unit Type: Standard
$ 107/unit per week
We need to rent 8 porta potties for a wedding next summer.
Maggie J.
Oakland, CA, 94661
Unit Type: Standard
$ 96/unit per week
Units need to be handicap accessible with foot pumps.
Susan H.
Oakland, CA, 94624
Unit Type: ADA Compliant
$ 239/unit per week
5 normal portable toilets for my church group in City. How much for an upscale unit?
Ariana F.
Oakland, CA, 94659
Unit Type: Standard
$ 80/unit per week
Not sure how many, just normal flushable porta potties for our church group in City. Do you have a hand washers?
Jared M.
Oakland, CA, 94623
Unit Type: Standard
$ 119/unit per week
Need to rent 9 porta potties for a party in a few months.
Peter D.
Oakland, CA, 94617
Unit Type: Standard
$ 124/unit per week


text:
Want to stay up to date on all of Shovelware Studios' projects? Join the group! The minions are rioting, and it's up to you and Gru (and Dru) to stop them! Travel through 30 fun and unique levels as you try to escape the minions in this Despicable Me 3 Adventure Obby! Scripting: Dogon, Miigator, Aurarus Level Design: Dogon, robloxian4545, Miigator Art Assets: bighead5852, MrVirtual, CraigX
Private Servers
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text:
Awareness Workshops
Ozark Highlands Trail Association Rendezvous '19
The Subaru/Leave No Trace Traveling Trainers will be joining the Ozark Highlands Trail Association Rendezvous '19, educating participants and park visitors at the Lake Fort Smith State Park pavilion. The day's activities will include public outreach, youth games and activities as part of National Kids to Parks Day and a Leave No Trace workshop open to Rendezvous participants and the public from 1:30 – 3:30 pm.
Click here to learn more.
Related Events
Let's protect and enjoy our natural world together
Get the latest in Leave No Trace eNews in your inbox so you can stay informed and involved.


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Estate Agents in Leyland
List of Leyland based commercial and residential property agencies offering houses, flats & commercial property for sale.
Business Listings
Moving Works offers all the benefits of a traditional Estate Agency, supported by the internet but with one major difference. The Moving Works listings adviser will visit your home to take your instructions for the property description, which includes room sizes. Up to six internal and external photographs will be taken, which will be downloaded onto our Web Site, together with the property description.
After a successful Football Career with Burnley and England, Brian Pilkington came into the Estate Agency Business. Since the mid-60's Brian has been at the helm of Leylands Longest Established Independent Estate Agents. Leyland is located at Junction 28 on the M6, A market town, within easy commuting distance to Preston, Manchester and Liverpool.
Lambert & Wakefield Estate Agents have been selling homes since 1998. We use the latest technology and techniques to sell your home, which remain unrivalled in the industry. For peace of mind we offer a No Sale - No Fee service, with no tie in period or contract. Our luxurious showrooms offer a wide selection of quality homes for sale, with experienced staff on hand to assist in both buying and selling
Town & Village is the largest estate agency in the Chorley area. Expert local knowledge and a friendly professional service help sell your property as quickly as is possible. Town & Village. Four traditional display offices working together with modern internet technology to find a buyer for your house. We operate on a no sale no fee basis with no registration or upfront charges. Our properties are


text:
Additional information
|1000 × 1000 mm
DKK2,312.50 inkl. moms
It is important to pay attention to landings on the stairs if you want to minimize the risk of falls.
Real Safety's landing covers with yellow "nose" will certainly ensure increased vigilance in the area. This happens automatically when you experience a different substrate where the visibility is improved via the yellow signal colour.
You also have the option to add a pictogram on the top step, for example: "Use handrail". Furthermore, this profile is made of 41% pure glass fibre and 59% resin, which provides high quality and a very strong product.
*Shipping will be calculated at checkout.
|1000 × 1000 mm
Do you want to make sure you order the right solution for your challenges or do you have a customer you want to introduce to our solutions? Please fill out the form below and get a free sample box – without any obligation.
*The offer is valid within Europe. Outside of Europe, shipping must be paid by the customer
This information is used ONLY to contact you regarding the sample box you order.


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A closely held secret of the best deal seekers is that there some days of the week are better than others for your purchases. By knowing what day of the week has the best deal for different types of things you're looking to purchase you can make the most of your shopping.
Christmas shopping can be a daunting task if you aren't prepared to shop around for the best bargains for the items on your list. Cyber Monday is a great way for you to save money and shop from the convenience of your own home. On December 1st this year you can log onto your favorite retailer websites and find amazing bargains on any gift you're thinking of purchasing for your friends and family.
Unless you've worked at a restaurant before, you might not know that Mondays are typically their slowest day of the week. To get over the slump in sales many restaurants offer specials on Mondays to entice hungry diners to come in and try them out. Keep your eyes open for signs in windows, restaurant websites, and for ads in the paper that will tell you how to score a delicious meal for cheap.
One of the most expensive parts of booking your next holiday is the airfare. Airlines have worked out complicated algorithms that let them know when most people purchase airfare and they boost the prices on those days. Recent studies by travel blogs have found that statistically Tuesday, specifically Tuesday afternoon around 3pm, is the best time for you to look for a plane ticket. Another trick is that actually flying out on Tuesday is the cheapest day to for you to start your trip.
If you love pizza as much as I do, chances are you already know that Tuesday is the best day to order a pizza. In recent years big chains like Dominos and Pizza Hut have run specials on Tuesday for a 2 for 1 deal. Not only is pizza delicious but this is a great way to feed the whole family a meal they'll love for less than it will cost you to make a meal at home.
Wednesday is a great day to head to the cinema and catch the latest films. There are many special prices you can take advantage of, such as a 2 for 1 movie ticket for Orange/EE customers. You can also get the same offer if you are a broadband customer.
Grab a megabus ticket on Wednesdays for no more than a fiver for travel anywhere on English and Welsh bus routes on Sid or Megabus. Megabus is already one of my favorite cheap ways to travel but this is a fantastic excuse to head out on Wednesday and look for some new sights.
If you're in the market for a new car you might have noticed that going to a dealer on the weekend can be a frighteningly stressful ordeal. A big part of that is the crowds of people looking at cars. Many people can't head out on a weekday to shop for a new car and without people competing to purchase a new car you can flex your negotiation skills and the dealer is more likely to work with you.
If you're looking for a night out on the town, Thursdays are a great day to look for promotions at nightclubs and bars. Many nightclubs are pushing to get their weekend started early by offering free admission and deep discounts on drinks so if you're willing to go to work Friday after a late night Thursday could be the best day of the week to go out.
Black Friday has been a shopping event the US for many years which has been adopted by UK retailers and there is no sign of it stopping soon. Some of the best deals of the year on the hottest gift items can be found on November 28th.
Many clothing retailers begin their sales on Fridays and if you can get out early you can beat the crowds and find the best deals. If you can't manage to head to the store on Friday don't despair, the deals run through the weekend.
Going to the cinema with a young child can be a daunting task, but Odeon has kid friendly films every Saturday and Sunday morning from only £2.50. The films may not be the newest release, but this is a great way for you to enjoy a film with your little one. Cineworld and Vue cinemas also run specials for children on second run movies.
My family had a tradition of going out to lunch after church on Sundays and I only understood why when I was older. Many restaurants run lunch specials where kids eat free. Crown Carveries, La Tasca, and Tony Romas all have amazing specials for you and let your children eat for free. You get to enjoy a nice meal and your kid gets to eat for free, you can't do much better than that!


text:
Automox is the easiest-to-use and most-recommended cloud-delivered solution for more efficient cyber hygiene and patch management.
Unify and simplify your endpoint management and configuration with a cross-platform solution that patches any Windows, macOS or Linux endpoint—whether they're on-prem, in the cloud or on the move.
Say goodbye to infrastructure and VPN hassles. Now, you can enforce your OS & third-party patch management, security configurations, and custom Automox Worklets from a single, cloud-native console.
Set the foundation for improved cyber hygiene with policy-driven security automation allows you to streamline the fundamentals of endpoint hardening, automatically securing your devices without hands-on maintenance.
Instantly see which endpoints are misconfigured, missing critical patches, or are out of compliance. Our modern UI gives you real-time patch management vulnerability status across your entire infrastructure.
A fully patched and correctly configured infrastructure is the cornerstone of strong corporate security. Bulletproof your infrastructure by leveraging the scale of automation. Our patch management software platform ensures every system is fully patched and correctly configured regardless of OS, software, or geographic location.
Do away with spreadsheets, manual updates, and feeling like your reports are never up to date or accurate. Our platform automates your status reporting and allows you to customize end user update notifications across Windows, macOS and Linux.


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Your Choice Barnet is a specialist social care organisation offering support to people with physical and learning disabilities. These range from visual and hearing impairments to autistic spectrum conditions and behaviours that may challenge services. These include a variety of day services, support for people to live independently in their own homes and short breaks (respite) service.
Physical and learning disabilities


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ager m roya nak or ansoon dono shoulder kharab kar dyn gy
eeeeeee uuuu then u should find another shoulder:-P
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AÆUÅÆØ / Nick Geboers
Roma Publication 334
The cryptic title forms a sequence of symbols and Danish sounds. AÆUÅÆØ roughly translates to 'I am out on an island'. The photographer therefore invites us to visit an island. What the precise nature of that island could be remains undetermined. In any case, it is not an existing island. The images in this book cannot be read as a documentary inventory of a real existing area, but rather as a poetic evocation of the idea 'island'. They explore the isolation, the sense of seclusion, specific to the existence of the islander. Each photograph is an isolated fragment, the whole a sequence of unfathomable appearances. The sublime landscapes, nature observations, archaic symbols and unknown rituals suggest an animistic world view in which every image, every human trace, seems like an echo of other times.
(more images on www.romapublications.org)


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Hi and welcome to the May edition of Inside Recliners. Firstly, thanks so much to all of you who have contacted us to say you're enjoying the content of these newsletters.
We try hard to bring you relevant articles and information that we see over the course of each month, so it's great to hear it's appreciated. We're always glad to receive comments and queries, so if there's anything you want to see more of, or anything you'd like to know about our range of specialist seating, please do get in touch. In the meantime, here's a quick roundup of what's been catching our eye this month.
The Recliners Team.
News and Events
Kidz to Adultz
This free event in Reading on the 8th June features more than 120 exhibitors dedicated to supporting young people with disabilities.
Did You Know?
We have 58 high quality fabric options, exclusive to Recliners Chairs in our new Swatch Fabric range.
OT News
The Pelvis – A Guide to the Different Positions of the Pelvis when Seated
Are your patients missing out on the benefits of technology?
Industry News
The Challenges Facing Mobility Retailers in 2017
Criteria for Comfort
Chair of the Month
The Windsor
Your Thoughts
As always, we welcome your comments, thoughts and questions. Anything more you'd like to see in our range? To know from our newsletters? Or to ask us in person?
Get in Touch with our friendly team with any of your feedback, comments or questions.


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2017 Honda Ridgeline: Second Time Is a Charm
The only controversial thing
about the second-generation Honda Ridgeline is how it has midsize-truck capabilities in a package that is as well executed
as an Accord sedan.
#Toyota #Acura #Honda
"Like its predecessor, the 2017 Ridgeline defies conventional wisdom with its unibody construction and all the benefits that brings in terms of ride, handling, packaging, safety and bed utility—as well as breakthrough features like the Truck Bed Audio system. The Ridgeline is the kind of product people expect of Honda—something challenging and innovative in how it seeks to create new value for the customer.
"It's to the credit of our North American R&D and manufacturing teams that this new Ridgeline is coming out of the blocks with such positive momentum." So states Jeff Conrad, senior vice president and general manager, Honda Division, American Honda Motor Co., Inc., of the second-generation of the pickup truck that follows in the tire treads of the first-gen vehicle that, when it rolled out of the Honda plant in Alliston, Ontario, Canada, was unlike what people then—and presumably now—considered to be pickup-truck-like in appearance.
Featured Content
And it all came down to one simple thing.
When you think of what a "pickup truck" looks like, regardless of manufacturer, you undoubtedly picture (1) a cab of varying size and configuration and (2) a rectangular box behind the cab. The two come together such that there is a 90-degree angle formed by the visual intersection of the back of the cab and the top of the box.
But back in 2005, when the Ridgeline was launched as a model year 2006 vehicle, the cab and the box came together not with an "L" shape, but as though a right triangle was inserted between the two. For many people this design not only seemed unusual—the whole notion of a unibody truck was futuristic onto itself, when "real" trucks had a good solid set of frame rails below, and here was something that seemed visually aerodynamic, and when you had things like the Dodge Ram 1500 with an upright, in-your-face grille that seemed to scoff at aero, that body side appearance wasn't an advantage for the Ridgeline—but it didn't seem like a "real" truck.
So the designers and engineers for the 2017 Ridgeline—designers in Torrance, California; engineers in Raymond, Ohio—went to work at that intersection, eliminating the "buttress-style" body structure in the forward portion of the bed, replacing it with a truss-style inner construction. Not only is there the visual benefit of appearing more truck-like, but there are actually benefits of the new approach: the torsional rigidity of the new model is 28 percent greater than that of the previous model. (There are also a couple of other advantages: (1) the side panel on the truck bed of the new model is easier to stamp than in the previous; (2) as there is now a more-conventional rear fender that is bolted in place, in case of collision, it can be more readily removed and replaced.)
But maybe we're getting ahead of ourselves here. Honda is about Accords and Civics, right? Well, while there are those, Honda actually has trucks in the forms of things like the CR-V and the Pilot, or over on the Acura side of the house, the RDX and the MDX. In fact, Honda has actually developed a Global Light Truck platform, which serves as the basis for the Ridgeline.
And they went at building a truck—it is being manufactured at Honda Manufacturing of Alabama in Lincoln—with serious structure for serious mid-size truck capability. Consider, for example, the fact that there are 1300-MPa ultra-high-strength steel door reinforcement beams and 1500-MPa hot-stamped and laser-welded front door outer stiffener rings. Ultra-high-strength steel accounts for 19.3 percent of the body. An additional 35.7 percent of the body structure is made with high-strength steel. (For those who now associate aluminum with pickups, know that the Ridgeline hood and front bumper reinforcement beam are made with the nonferrous material. The steering hanger beam is cast magnesium.
The bed is a glass-fiber reinforced SMC composite.) This results in a vehicle that is as much as 73 pounds lighter than its predecessor (the curb weight of the 2017 Ridgeline ranges from a base model with 2WD at 4,242 pounds to the top-of-the-line 4WD model at 4,515 pounds) even though it is dimensionally bigger (length: 210 inches vs. 206.9 inches; height: 70.8 inches vs. 70.3 inches; width: 78.6 inches vs. 77.8 inches; bed length: 64 inches vs. 60 inches).
From the point of view of midsize truck capability, it offers a maximum payload capacity of up to 1,584 pounds and towing up to 5,000 pounds.
The overall execution of the vehicle was done such that it not only met the attributes of competitors like the Chevrolet Colorado and the Toyota Tacoma, but bested them. For example, the Ridgeline offers 109-ft3 of passenger space compared with the Colorado's 107-ft3 and the Tacoma's 100-ft3. It offers a width of 50 inches between the wheelhouses in the bed, compared with 44 inches for the Colorado and 42.5 inches for the Tacoma. With the tailgate up, the bed length is 63.3 inches compared with 61.3 inches for the Colorado and 59.9 inches for the Tacoma. (And like its predecessor, it still offers the "trunk" in the bed, this time a storage space that can swallow an 82-quart cooler.) (Speaking of the bed: way back in the opening paragraph Jeff Conrad mentions "Truck Bed Audio."
This system, thought to be the first in a production vehicle, uses six weatherproof (i.e., they're inside the sheet metal) transducers, two each in the bed side walls and the bed rear wall, that transmit vibrations into those walls, turning them into resonant speakers. This is something that is truly engineered for purposes of tailgating, as it doesn't work at speeds of 10 mph or more. And while speaking of audio—this bed-as-speaker system is part of a 540-watt audio setup—know that Apple CarPlay and Android Auto are available for the Ridgeline.)
The 2017 Ridgeline is powered by a 3.5-liter, direct injection V6 engine that provides 280 hp @ 6,000 rpm and 262 lb-ft of torque at 4,700 rpm. The engine is mated to a six-speed automatic transmission. In an AWD vehicle, the estimated EPA fuel economy is 18/25/21 mpg city/highway/combined; it is 19/26/22 mpg for the 2WD version.
It is worth noting that another change between the last generation and the new one is that before all Ridgelines were 4WD. The all-wheel-drive system used for the Ridgeline, an electro-hydraulic system, provides torque vectoring: it automatically distributes torque between the front and rear axles as well as between the left and right rear wheels, depending on conditions. There is an "Intelligent Traction Management" system that provides pushbutton selection of Normal, Snow, Mud and Sand for the AWD models (Normal and Snow for 2WD) that adjusts the drive-by-wire map, the transmission shift map, vehicle stability control and the torque distribution based on the surface conditions.
While things like the torsional rigidity and the size of the box and the ability to deal with snow, mud and rocks are all things that various truck manufacturers can throw numbers at one another regarding, there is something at which the fundamental unibody construction of the Ridgeline makes it absolutely remarkable: the ride and handling.
The Ridgeline features fully independent front and rear suspension systems (MacPherson struts in the front; multilink in the back). It also has amplitude reactive dampers that are based on two separate damping pistons, with one piston reacting in response to the small inputs characteristic of normal driving conditions and the other to provide the additional damping required when on rough surfaces or during aggressive driving.
Not only is the interior of the Ridgeline car-like in its execution and refinement, but the vehicle is engineered so that whether or not there is a load in the bed, the suspension provides sedan-like driving characteristics.
In other words, with the capabilities of the bed, the NVH of the overall vehicle and the amenities on the inside, the Honda Ridgeline is, again, an outlier, but this time it is for all the right things.


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WHEN it comes to a day on the beach, there's no excuse to leave your sense of style in the hotel room. The wise fashionista knows that the bag she uses to carry her poolside essentials is just as important as the swimwear and shades she chooses.
Obviously, practicality needs to pretty high up on the list – an over-sized leather Mulberry is hardly the sensible choice. But there are plenty of waterproof and straw options on the high street that are as chic as they are sensible.
1: This plastic Per Una bag certainly sent my heart aflutter, with its floral and bead detailing. From Marks & Spencer, it costs £25.
2: From Accessorize, this white trim basket bag has a plaited handle and gold detailing for a designer look. It costs £28.
3: TK Maxx has a great selection of brightly coloured weave bags to pick up on key colours from your summer wardrobe. This pink and green one is £7.99 (styles vary from store to store).
4: Talk about practical, from Bhs this beach bag is made from towelling so if it does get wet after a day on the beach simply dry it out on the balcony. It costs £20.
Note: Due to the summer sales, the items featured may well be reduced.
* Lisa Piddington is web editor of stylebirmingham.com, a website dedicated to Brum style and fashion.


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Mayor Of LA Calls For 10,000 More Police
Jay Leno joked during his Tonight Show monologue on Friday night, "You hear about this? The mayor of Los Angeles has called for 10,000 more police, and that's just to take Britney Spears to the hospital. … Did you see that on the news the other night? You know, I'm sorry. I feel sorry for the girl. But really, 12 motorcycle police officers, plus a a helicopter, to pick up Britney at her house. And what was the helicopter for? Why do you need a helicopter? Is that in case she wasn't wearing any underwear? The breeze from the blades would keep her skirt down. Is was that what the idea was?"


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Review ARTICLE
CaMKII in sinoatrial node physiology and dysfunction
- 1Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
- 2Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
The calcium and calmodulin-dependent protein kinase II (CaMKII) is present in sinoatrial node (SAN) pacemaker cells and is required for physiological "fight or flight" SAN beating rate responses. Inhibition of CaMKII in SAN does not affect baseline heart rate, but reduces heart rate increases in response to physiological stress. CaMKII senses intracellular calcium (Ca2+) changes, oxidation status, and hyperglycemia to phosphorylate substrates that regulate Ca2+-sensitive proteins, such as L-type Ca2+ channels, phospholamban, and cardiac ryanodine receptors (RyR2). All of these substrates are involved in the SAN pacemaking mechanism. Excessive CaMKII activity, as occurs under pathological conditions such as heart failure, ischemia, and diabetes, can promote intracellular Ca2+ overload and reactive oxygen species production. Oxidation of CaMKII (ox-CaMKII) locks CaMKII into a constitutively active configuration that contributes to SAN cell apoptosis and fibrosis. This ox-CaMKII-mediated loss of functional SAN cells contributes to SAN dysfunction (SND) and sudden death. Thus, CaMKII has emerged as a central regulator of physiological SAN responses and a key determinant of SND.
The sinoatrial node (SAN) is a specialized region of heart tissue present at the junction of the right atrium and superior vena cava that extends along the cristae terminalis, where it initiates each normal heart beat. The pacemaking function of SAN cells is accomplished by generation of spontaneous action potentials. There appear to be redundant systems in SAN for generating spontaneous cell membrane potential depolarizations, which are ultimately necessary to sustain life by maintaining cardiac output. One of these systems comprises a set of cell membrane delimited ion channels. These ion channels include hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that conduct an inward current, sometimes called a pacemaker current or funny current (If; DiFrancesco, 1991), L-type (CaV1.2/1.3; Christel et al., 2012) and T-type (CaV3.1/3.2) Ca2+ channels (Mangoni et al., 2006; Tanaka et al., 2008; Brahmajothi et al., 2010) and several K+ channels, including ERG (Brahmajothi et al., 1997, 2010) and KvLQT1 (Chandler et al., 2009; Brahmajothi et al., 2010 ). All of these ion channels have the potential to play a role in pacemaking under different conditions. The other system involves intracellular Ca2+ machinery that is used for excitation–contraction coupling in mechanically purposed myocardium, but that contributes to rhythmic intracellular Ca2+ oscillations in SAN. This system enables SAN fight or flight heart rate increases and contributes to SAN cell death under pathological stress. These components include the sarcoplasmic reticulum (SR; Rigg and Terrar, 1996), which contains the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2a), the ryanodine receptor 2 (RYR2), a large Ca2+ channel that releases Ca2+ from the SR lumen to the cytoplasm and the cell membrane spanning Na+/Ca2+ exchanger (NCX1; Sanders et al., 2006). The components in both systems collaborate but are also capable of independent activity that ensures nonstop pacemaking activity (Lakatta and DiFrancesco, 2009; Lakatta et al., 2010).
We believe that the effects of the multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) on SAN cell biology are related to actions on Ca2+ homeostasis. CaMKII is a multifunctional serine/threonine-specific protein kinase that is initially activated by the Ca2+/calmodulin complex (Schulman and Greengard, 1978). CaMKII is present in contracting myocardium and in SAN cells (Vinogradova et al., 2000). Details of CaMKII structure, function, activation, and inactivation are contained in another chapter in this compendium (XYZ). However, the CaMKII holomeric structure allows it to perform as a precisely regulated enzyme that activates and inactivates with Ca2+/calmodulin binding and unbinding but also to transition into a constitutively active conformation by post-translational modifications to the autoregulatory domain (Kuret and Schulman, 1985; Erickson et al., 2008, 2013; Chao et al., 2011; Gutierrez et al., 2013). Excessive levels of constitutively active CaMKII are linked to cardiovascular and pulmonary diseases, including SAN dysfunction (SND; Erickson et al., 2011; Sanders et al., 2013).
CaMKII in SAN Physiology
Activated CaMKII can catalyze phosphorylation of multiple Ca2+ homeostatic proteins, including L-type, e.g., CaV1.2 (Dzhura et al., 2000; Grueter et al., 2006) and T-type, e.g., CaV3.2 (Yao et al., 2006) Ca2+ channels, phospholamban (PLN; Lindemann et al., 1983), a protein that negatively regulates SERCA2a in the absence of CaMKII or protein kinase A catalyzed phosphorylation (Kranias and Hajjar, 2012), and RYR2 (Witcher et al., 1991; Wehrens et al., 2004). CaMKII catalyzed phosphorylation increases Ca2+ entry through Ca2+ channels, increases SERCA2a uptake of cytoplasmic Ca2+ into the SR lumen through phosphorylating PLN, which in turn increases the pool of SR releasable Ca2+, increases Ca2+ release from RYR2 by phosphorylation of RYR2 at several sites, including serine 2814. On one hand, these effects will increase intracellular Ca2+ flux through the SR and RYR2 to accelerate NCX1 to increase SAN cell action potential frequency and the physiological fight or flight heart rate response. On the other hand, excessive CaMKII activity will cause Ca2+ overload (Wagner et al., 2011), which can induce increased reactive oxygen species (ROS) production and cause SAN cell damage or death (Swaminathan et al., 2011; Luo et al., 2013).
The role of CaMKII in SAN function has been explored since 1989 (Hagiwara and Irisawa, 1989). The major focus of this study was on the effects of calmodulin or CaMKII on If currents by using calmidazolium, a calmodulin inhibitor with many off target actions (Klöckner and Isenberg, 1987). They found that If currents were sensitive to intracellular Ca2+ but no evidence that If was regulated by CaMKII. A more recent study (Rigg et al., 2003) confirmed that If currents are regulated by Ca2+ and calmodulin but not by the CaMKII pathway. They showed that If current amplitude was unaffected by the CaMKII inhibitor KN-93 (1 μM) although this CaMKII inhibition did reduce L-type Ca2+ current by 48 ± 19% at 0 mV voltage clamp command potential. However, a more recent study challenged the concept of calmodulin regulation of If (Chatelier et al., 2005) based on experiments in inside-out cell membrane macro-patches excised from rabbit SAN cells. They found that "intracellular" calmodulin perfusion had no effect on HCN activity and did not change the cAMP-induced If activation shift. This study suggested that another calmodulin inhibitor, W-7, with well documented off target actions had direct effects on If that were independent of Ca2+ and calmodulin. The myriad off target actions on ion channels represent major obstacles to the use of CaMKII inhibitors in functional studies ( Ledoux et al., 1999; Gao et al., 2006; Rezazadeh et al., 2006; Liao et al., 2011). CaMKII enhances CaV1.2 channel currents in ventricular myocytes (Anderson et al., 1994; Xiao et al., 1994; Yuan and Bers, 1994) and so could potentially affect SAN automaticity by actions on CaV1.2. A paper from the Xiao group showed that CaMKII was likely to play an important role in SAN pacemaker activity by actions at voltage-gated Ca2+ channels (Vinogradova et al., 2000). They were able to stop SAN cell automaticity by using CaMKII inhibitors KN-93 or myristoylated autocamtide-2-related inhibitory peptide (AIP) (a cell membrane permeant peptide inhibitor modeled after the CaMKII autoinhibitory region). The findings from the Xiao group supported an If-independent role for cardiac pacing. However, these studies were mostly performed using small molecule inhibitors with off target actions that complicate interpretation of the results. Taken together, these findings highlight some of the limitations of available small molecule calmodulin and CaMKII antagonists and suggest that If is not directly responsive to calmodulin or CaMKII but leave open the question whether CaMKII actions at CaV1.2 channels contribute to SAN automaticity. We developed a mouse with myocardial targeted transgenic expression of AC3-I, a highly selective CaMKII inhibitory peptide, under control of the α-myosin heavy chain promoter (Zhang et al., 2005). AC3-I expression was present in SAN cells and a study from our group using this mouse found that CaMKII inhibition did not affect baseline SAN pacemaking activity but selectively impaired the fight or flight response of SAN cells to isoproterenol (Wu et al., 2009). CaMKII was responsible for approximately half of the dynamic heart rate response range. We found that neither SAN cell Ca2+ channels nor If currents from AC3-I mice were different compared with their WT littermates nor control transgenic mice expressing AC3-C, an AC3-I like peptide without biological activity. We found that SR Ca2+ content responses to isoproterenol in those mice were reduced, potentially as a consequence of diminished CaMKII catalyzed phosphorylation of PLN. The reduced SR Ca2+ content likely contributed to reduced Ca2+ spark frequency as well as decreased Ca2+ release from SR (Figure 1). Our findings were later confirmed by studies from another group using a CaMKIIδ knock out mouse (Xu et al., 2010). Their study also showed that CaMKII is required for heart rate increases by isoproterenol stimulation or in response to a physiological fight or flight mechanism. A recent study from Terrar group (Collins and Terrar, 2012) suggested that the effect of CaMKII in atrial myocytes may be primarily on SR proteins due to different distribution of CaMKII in ventricular myocytes compare to atrial myocytes which lack of T-tube. The effects of CaMKII on atrial Ca2+ channels are indirectly through CaMKII enhanced SR Ca2+ releasee that stimulates adenylyl cyclases (ACs). Recently, one study from Lakatta group using KN-93, myristoylated AIP, and W-7 to inhibit CaMKII (Yaniv et al., 2013) suggest that CaMKII may affect SAN automaticity by actions on metabolism. In our opinion, these results are intriguing but inconclusive because of the documented off-target actions of these reagents (Ledoux et al., 1999; Chatelier et al., 2005; Gao et al., 2006; Rezazadeh et al., 2006; Liao et al., 2011). Taken together, these studies support a view that CaMKII is not required to maintain basal heart rates but plays a critical role in sustained heart rate increases during physiological stress. This selective role of CaMKII on heart rate suggests that CaMKII inhibition could protect against excessive heart rates without reducing baseline heart rate.
FIGURE 1. Mechanism of CaMKII effects on Fight or Flight in SA node. (A) Fight or flight stimulation (e.g., isoproterenol) activates PKA and CaMKII, which phosphorylate L-type Ca2+ channels and PLN to increase SR Ca2+ content. RYR2 phosphorylation increases Ca2+ release from SR. Increased Ca2+ release accelerates NCX1 activity which increases the diastolic depolarization rate (DDR) of SAN action potentials (B). SR Ca2+ content increases by isoproterenol are abolished by CaMKII inhibition. Upper panel shows DDR change with isoproterenol (red trace) compare to control DDR (black trace), MDP, maximal diastolic potential. Middle panel shows Ca2+ spark frequency increases after isoproterenol are abolished by CaMKII inhibition. The lower panel shows the heart rate increase by isoproterenol is abolished by CaMKII inhibition. All shaded bars in bar graphs represent data with isoproterenol effects. Both white bars (WT control) and black bars (transgenic control) represent data from control SAN. *p < 0.05, ***p < 0.001 before vs. after isoproterenol, † p < 0.05 compare to control SAN groups, †† or ‡ p < 0.01 compare to control SAN groups.
CaMKII in SND
Conditions that favor SND, such as heart failure, atrial fibrillation (AF), and advanced age are marked by heightened ROS (Cesselli et al., 2001; Kim et al., 2005; Dai et al., 2009). Because CaMKII is activated by ROS (Erickson et al., 2008) in the setting of increased angiotensin II (Ang II), a circulating neurohormone present at increased levels in heart failure, we tested if oxidized CaMKII (ox-CaMKII) could contribute to SND. We found Ang II increased atrial and SAN oxidation by activating NADPH oxidase, leading to increased ox-CaMKII, SAN cell apoptosis, and SND (Swaminathan et al., 2011). In order to test whether elevated ox-CaMKII could cause SND, mice were infused with Ang II. Ang II infusion for 3 weeks caused increased SAN ox-CaMKII, SAN cell apoptosis, fibrosis, slowed atrial impulse conduction velocity, and SND. Ang II-triggered SND was prevented by transgenic myocardial and SAN cell expression of AC3-I (Zhang et al., 2005) and by SAN-targeted gene therapy (Kikuchi et al., 2005) providing ectopic SAN expression of a CaMKII inhibitory peptide, CaMKIIN, that is endogenous to neurons but absent in heart (Chang et al., 1998). Neither transgenic nor gene-targeting approaches to SAN CaMKII inhibition affected the hypertensive response to Ang II, nor did they abrogate the increased SAN ROS due to Ang II infusion, indicating that CaMKII was a critical downstream signal for the pathological actions of ROS on SAN. The increase in SAN ox-CaMKII by Ang II required activation of NADPH oxidase, because it was absent in p47-/- mice (Huang et al., 2000) lacking functional NADPH oxidase. We developed a structural and computational model of the SAN that revealed a quantitative mechanism to explain how Ang II-induced SAN cell apoptosis resulted in SND by reducing SAN cell number and increasing electrotonic loading of surviving SAN cells to cause loss of high-fidelity impulse formation and propagation (Figure 2; Huke and Knollmann, 2011). We also found that right atrial tissue from patients with heart failure who required artificial pacemakers for SND or dogs with pacing-induced heart failure and SND had elevated ox-CaMKII compared with patients with heart failure alone or dogs with non-SND controls. These findings provide insights into how excessive activation of CaMKII in SAN cells causes SND, suggest ox-CaMKII is a biomarker for SND and identify what we believe to be a novel candidate approach to preventing SND in high risk settings by CaMKII inhibition.
FIGURE 2. Mechanism of Ang II-induced SND. Normally, the small volume of excited tissue in the SAN (source) depolarizes the neighboring quiescent atrial tissue (sink). In conditions with increased Ang II, NADPH oxidase is activated, leading to oxidation of two methionine residues of CaMKII, rendering the enzyme autonomously active. Elevated activity of CaMKII leads to SAN cell death, reducing the threshold volume of automatic cells of the SAN and increasing non-excitable tissue in the form of fibrosis. This increased electrotonic loading produces a source-sink mismatch slows the beating rate, and causes SND. CT, crista terminalis; IAS, inferior atrial septum. Reproduced from Huke and Knollmann (2011), with permission from JCI.
Patients with AF are at increased risk for SND (Chang et al., 2013) and CaMKII activity and expression are increased in fibrillating human atria (Neef et al., 2010). We recently found that ox-CaMKII is increased in fibrillating compared to non-fibrillating human atria and that Ang II infusion increases AF induction in mice (Purohit et al., 2013). Mice with transgenic expression of AC3-I, mice with a knock-in mutation (MM-VV) in CaMKIIδ that prevents oxidative activation and mice with transgenic over-expression of methionine sulfoxide reductase A that reverses the first oxidation state (sulfoxide) of methionine were all resistant to Ang II-induced AF. We interpret these findings to suggest that ox-CaMKII is a unifying signal for SND and AF.
Diabetes is a risk factor for SND (Podlaha and Falk, 1992). We recently found significantly more ox-CaMKII in right atrium from patients with a history of diabetes and myocardial infarction (MI) compared with right atrial tissue from patients with MI but no diabetes, suggesting that ox-CaMKII could contribute to the increased mortality in diabetic patients after MI (Luo et al., 2013). Streptozotocin (STZ)-treated mice develop severe type I diabetes due to death of pancreatic β-cells. STZ-treated diabetic mice were twice as likely to die after MI surgery as vehicle-treated control mice, mimicking the increased mortality in diabetic patients compared with that in non-diabetic patients after MI. STZ-treated MM-VV mice and mice with transgenic myocardial and SAN expression of AC3-I (Zhang et al., 2005) were protected from increased mortality after MI, indicating that increased ox-CaMKII was essential for excess mortality after MI in STZ-treated mice. Death in STZ-treated mice after MI was due to severe bradycardia, consistent with known defects in cardiac pacemaker function in another diabetic animal model (Howarth et al., 2007). In contrast to our earlier studies with Ang II-triggered ROS by activation of NADPH oxidase (Swaminathan et al., 2011), we found that hyperglycemia-induced ROS were primarily from mitochondria. Excess mortality in STZ-treated diabetic mice after MI surgery was prevented by chronic infusion with a mitochondrial targeted antioxidant, Mito-TEMPO. Mito-TEMPO reduced ox-CaMKII, preserved heart rates, and improved survival after MI. These results provide new evidence that ox-CaMKII is a biomarker for SND and suggest that mitochondrial or CaMKII-targeted antioxidant therapies could benefit high-risk diabetic patients.
In summary, CaMKII appears to play important roles in tuning the fight or flight response and in promoting SND. It may be that the physiological benefits of CaMKII activation in early life are outweighed in later life by the tendency of CaMKII to become persistently active under conditions of high oxidative, neurohumoral and hyperglycemic stress. The tractability of CaMKII as a target for selectively controlling heart rate and preventing SND will depend upon the availability of clinically suitable CaMKII inhibitory drugs or gene therapy.
Conflict of Interest Statement
Mark E. Anderson is a cofounder of Allosteros Therapeutics, a biotech aiming to treat cardiovascular disease by enzyme inhibition.
Shawn Roach for graphic design. This work was funded by National Institutes of Health (NIH) Grants R01-HL 079031, R01-HL096652, and R01-HL070250, R01-HL071140 and the Fondation LeducqTransatlantic Alliance for CaMKII Signaling, 08CVD01.
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Gutierrez, D. A., Fernandez-Tenorio, M., Ogrodnik, J., and Niggli, E. (2013). NO-dependent CaMKII activation during β-adrenergic stimulation of cardiac muscle. Cardiovasc. Res. 100, 392–401. doi: 10.1093/cvr/cvt201
Hagiwara, N., and Irisawa, H. (1989). Modulation by intracellular Ca2+ of the hyperpolarization-activated inward current in rabbit single sino-atrial node cells. J. Physiol. 409, 121–141.
Howarth, F. C., Al-Sharhan, R., Al-Hammadi, A., and Qureshi, M. A. (2007). Effects of streptozotocin-induced diabetes on action potentials in the sinoatrial node compared with other regions of the rat heart. Mol. Cell Biochem. 300, 39–46. doi: 10.1007/s11010-006-9366-5
Huang, C. K., Zhan, L., Hannigan, M. O., Ai, Y., and Leto, T. L. (2000). P47(phox)-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and db/+. J. Leukoc. Biol. 67, 210–215.
Huke, S., and Knollmann, B. C. (2011). Oxidized CaMKII: a "heart stopper" for the sinus node? J. Clin. Invest. 121, 2975–2977. doi: 10.1172/JCI58389
Kikuchi, K., McDonald, A. D., Sasano, T., and Donahue, J. K. (2005). Targeted modification of atrial electrophysiology by homogeneous transmural atrial gene transfer. Circulation 111, 264–270. doi: 10.1161/01.CIR.0000153338.47507.83
Kim, Y. M., Guzik, T. J., Zhang, Y. H., Zhang, M. H., Kattach, H., Ratnatunga, C., et al. (2005). A myocardial Nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation. Circ. Res. 97, 629–636. doi: 10.1161/01.RES.0000183735.09871.61
Klöckner, U., and Isenberg, G. (1987). Calmodulin antagonists depress calcium and potassium currents in ventricular and vascular myocytes. Am. J. Physiol. 253(6 Pt 2), H1601–H1611.
Kranias, E. G., and Hajjar, R. J. (2012). Modulation of cardiac contractility by the phospholamban/SERCA2a regulatome. Circ. Res. 110, 1646–1660. doi: 10.1161/CIRCRESAHA.111.259754
Kuret, J., and Schulman, H. (1985). Mechanism of autophosphorylation of the multifunctional Ca2+/calmodulin-dependent protein kinase. J. Biol. Chem. 260, 6427–6433.
Lakatta, E. G., and DiFrancesco, D. (2009). What keeps us ticking: a funny current, a calcium clock, or both? J. Mol. Cell Cardiol. 47, 157–170. doi: 10.1016/j.yjmcc.2009.03.022
Lakatta, E. G., Maltsev, V. A., and Vinogradova, T. M. (2010). A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ. Res. 106, 659–673. doi: 10.1161/CIRCRESAHA.109.206078
Ledoux, J., Chartier, D., and Leblanc, N. (1999). Inhibitors of calmodulin-dependent protein kinase are nonspecific blockers of voltage-dependent K+ channels in vascular myocytes. J. Pharmacol. Exp. Ther. 290, 1165–1174.
Liao, Z., St Clair, J. R., Larson, E. D., and Proenza, C. (2011). Myristoylated peptides potentiate the funny current (I(f)) in sinoatrial myocytes. Channels (Austin) 5, 115–119. doi: 10.4161/chan.5.2.14195
Lindemann, J. P., Jones, L. R., Hathaway, D. R., Henry, B. G., and Watanabe, A. M. (1983). beta-Adrenergic stimulation of phospholamban phosphorylation and Ca2+-ATPase activity in guinea pig ventricles. J. Biol. Chem. 258, 464–471.
Luo, M., Guan, X., Luczak, E. D., Lang, D., Kutschke, W., Gao, Z., et al. (2013). Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J. Clin. Invest. 123, 1262–1274. doi: 10.1172/JCI65268
Mangoni, M. E., Traboulsie, A., Leoni, A. L., Couette, B., Marger, L., Le Quang, K., et al. (2006). Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1/alpha1G T-type calcium channels. Circ. Res. 98, 1422–1430. doi: 10.1161/01.RES.0000225862.14314.49
Neef, S., Dybkova, N., Sossalla, S., Ort, K. R., Fluschnik, N., Neumann, K., et al. (2010). CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation. Circ. Res. 106, 1134–1144. doi: 10.1161/CIRCRESAHA.109.203836
Podlaha, R., and Falk, A. (1992). The prevalence of diabetes mellitus and other risk factors of atherosclerosis in bradycardia requiring pacemaker treatment. Horm. Metab. Res. Suppl. 26, 84–87.
Purohit, A., Rokita, A. G., Guan, X., Chen, B., Koval, O. M., Voigt, N., et al. (2013). Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation 128, 1748–1757. doi: 10.1161/CIRCULATIONAHA.113.003313
Rezazadeh, S., Claydon, T. W., and Fedida, D. (2006). KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J. Pharmacol. Exp. Ther. 317, 292–299. doi: 10.1124/jpet.105.097618
Rigg, L., Mattick, P. A., Heath, B. M., and Terrar, D. A. (2003). Modulation of the hyperpolarization-activated current (I(f)) by calcium and calmodulin in the guinea-pig sino-atrial node. Cardiovasc. Res. 57, 497–504. doi: 10.1016/S0008-6363(02)00668-5
Rigg, L., and Terrar, D. A. (1996). Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node. Exp. Physiol. 81, 877–880.
Sanders, L., Rakovic, S., Lowe, M., Mattick, P. A., and Terrar, D. A. (2006). Fundamental importance of Na+Ca2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node. J. Physiol. 571(Pt 3), 639–649. doi: 10.1113/jphysiol.2005.100305
Sanders, P. N., Koval, O. M., Jaffer, O. A., Prasad, A. M., Businga, T. R., Scott, J. A., et al. (2013). CaMKII is essential for the proasthmatic effects of oxidation. Sci. Transl. Med. 5, 195ra97. doi: 10.1126/scitranslmed.3006135
Schulman, H., and Greengard, P. (1978). Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein. Nature 271, 478–479. doi: 10.1038/271478a0
Swaminathan, P. D., Purohit, A., Soni, S., Voigt, N., Singh, M. V., Glukhov, A. V., et al. (2011). Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J. Clin. Invest. 121, 3277–3288. doi: 10.1172/JCI57833
Tanaka, H., Komikado, C., Namekata, I., Nakamura, H., Suzuki, M., Tsuneoka, Y., et al. (2008). Species difference in the contribution of T-type calcium current to cardiac pacemaking as revealed by r(-)-efonidipine. J. Pharmacol. Sci. 107, 99–102 doi: 10.1254/jphs.SC0070405
Vinogradova, T. M., Zhou, Y. Y., Bogdanov, K. Y., Yang, D., Kuschel, M., Cheng, H., et al. (2000). Sinoatrial node pacemaker activity requires Ca (2+)/calmodulin-dependent protein kinase II activation. Circ. Res. 87, 760–767. doi: 10.1161/01.RES.87.9.760
Wagner, S., Ruff, H. M., Weber, S. L., Bellmann, S., Sowa, T., Schulte, T., et al. (2011). Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload. Circ. Res. 108, 555–565. doi: 10.1161/CIRCRESAHA.110.221911
Wehrens, X. H., Lehnart, S. E., Reiken, S. R., and Marks, A. R. (2004). Ca2+/calmodulindependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ. Res. 94, e61–e70. doi: 10.1161/01.RES.0000125626.33738.E2
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Wu, Y., Gao, Z., Chen, B., Koval, O. M., Singh, M. V., Guan, X., et al. (2009). Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc. Natl. Acad. Sci. U. S. A. 106, 5972–5977. doi: 10.1073/pnas.0806422106
Xiao, R. P., Cheng, H., Lederer, W. J., Suzuki, T., and Lakatta, E. G. (1994). Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx. Proc. Natl. Acad. Sci. U. S. A. 91, 9659–9663. doi: 10.1073/pnas.91.20.9659
Xu, L., Lai, D., Cheng, J., Lim, H. J., Keskanokwong, T., Backs, J., et al. (2010). Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice. Circ. Res. 107, 398–407. doi: 10.1161/CIRCRESAHA.110.222562
Yaniv, Y., Spurgeon, H. A., Ziman, B. D., and Lakatta, E. G. (2013). Ca2+/calmodulin-dependent protein kinase II (CaMKII) activity and sinoatrial nodal pacemaker cell energetics. PLoS ONE 8:e57079. doi: 10.1371/journal.pone.0057079
Yao, J., Davies, L. A., Howard, J. D., Adney, S. K., Welsby, P. J., Howell, N., et al. (2006). Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II. J. Clin. Invest. 116, 2403–2412. doi: 10.1172/JCI27918
Yuan, W., and Bers, D. M. (1994). Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase. Am. J. Physiol. 267(3 Pt 2), H982–H993.
Zhang, R., Khoo, M. S., Wu, Y., Yang, Y., Grueter, C. E., Ni, G., et al. (2005). Calmodulin kinase II inhibition protects against structural heart disease. Nat. Med. 11, 409–417. doi: 10.1038/nm1215
Keywords: calcium/calmodulin-dependent protein kinase II, sinoatrial node, heart rate, sinoatrial node dysfunction, calcium
Citation: Wu Y and Anderson ME (2014) CaMKII in sinoatrial node physiology and dysfunction. Front. Pharmacol. 5:48. doi: 10.3389/fphar.2014.00048
Received: 16 January 2014; Accepted: 03 March 2014;
Published online: 18 March 2014.
Edited by:Donald M. Bers, University of California, Davis, USA
Reviewed by:Zhandi Liao, University of California, Davis, USA
Satoshi Matsuoka, University of Fukui, Japan
Copyright © 2014 Wu and Anderson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Mark E. Anderson, Department of Internal Medicine and Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA e-mail: email@example.com


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Nominations for the CIVSEC 2018 Innovation Awards have opened. The Awards recognise innovation by Australian individuals and organisations in products, services and business processes relating to Cyber Security, Physical Security & Policing and the Disaster Relief, Emergency Management & Humanitarian fields.
The Awards will be presented during the CIVSEC 2018 Congress and nominations close COB on 12 March 2018.
Full details are available from the CivSec 2018 Congress and Exposition website.
The Victorian Government's Defence Industry eNewsletter keeps decision makers and Australia's defence industry informed about the latest news and developments in Victoria's defence sector.


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Main Content
Session Information
06 SES 08, Future Classroom? Integrating Media and Changing Environments and Patterns
Paper Session
This work shows partial results of the Research Excellence Project "Best practices in integrating ICT in Primary and Secondary Schools of Andalucía (P07-HUM-03 035). This project is funded by the Department of Innovation, Science and Enterprise. Is a multiple case study, which present two cases of Primary Schools. It is a question of a multiple study of cases, of the fact that we sense beforehand here two cases of centers of Primary Education, in which there have been in use diverse qualitative strategies (opened interviews, observations participants, documentary analysis, audio-visual records…).
The presence of the technologies in the education already is not an innovation but a reality. The contexts of education - learning have changed with his alone appearance in the classroom, at least materiallyThe question that we must do to us is if they have changed also the processes and the manners of playing the role of the involved persons. To have high expectations on the media, given his potentials for the data processing, it must not prevent us from evaluating and thinking about his aptitude to transform the information into knowledge. The object it are neither the media or the technology. The object of evaluation and reflection we are we and our pupils, the contexts of education - learning that we design and put into practice, and, insertions in them, the utilization of the technological resources for the generation of knowledge. The object, definitively, always is the education.
Recently Almerich, Suárez, Orellana and Díaz (2010) have analyzed the relation between the integration of the TIC and his knowledge finding a significant relation between technological competitions and pedagogic competitions. Boza, Tirado y Guzmán (2010) investigate in the influence of the beliefs of the teachers on the TIC in his insertion in the educational Andalusian centers concluding that the teachers who have some belief formed on the integration of the technology in the education are more qualified technologically that the incredulous ones, feel more satisfied with the formation in which they were involved, with the resources, materials and technological infrastructure. Area (2005) does a review of the lines of investigation in TIC in the educational system. One of four lines that it checks names her as studies on the uses and pedagogic practices with computers in royal contexts of centers and classrooms, indicating that treats itself about studies with methodological qualitative expositions of studies of case. Boza, Toscano y Méndez (2009) analyze the impact of the projects TIC in the organization and the processes of education - learning from an investigative approach of mixed character.
This study takes as a principal aim the rigorous analysis of the presence of the computers in the classrooms of class of a massive form for his integration as ordinary resource for the education and the learning. The enormous investing effort of the administrations in endowments and maintenance of the equipments needs these studies, which try to identify a set of good didactic practices that allow to indicate future guidelines of action for a profitable integration of the TICs in the education.
Therefore, the followed methodology is and the design of the investigation is transverse since we gather the information of the reality in an alone temporary moment (during an academic course). The massive withdrawal of information has been realized in the central phase.
The population on whom the investigation has been realized the centers constitute actually Andalusian Tics. To select the cases we have used a sampling of typical ideal case but obtaining the cases based on triangulation of expert informants. In this sense, they are 10 the analyzed cases.
Expected Outcomes
Almerich, G.; Suárez, J.M.; Orellana, N. and Díaz, M.I. (2010). The relation between the integration of the technologies of the information and communication and his knowledge. Magazine of Educational Investigation, vol. 28, n º 1, 31-50. Area, M. (2005). Technologies of the information and communication in the school system. A review of the lines of investigation. RELIEF: vol. 11, n º 1, 3-25. Recovered of http: // www.uv.es/RELIEVE/v11n1/RELIEVEv11n1_1.htm Boza, Á.; Tirado, R. y Guzmán, M. D. (2010). Beliefs of the professorship on the meaning of the technology in the education: it influences for his insertion in the Andalusian teaching institutions. RELIEF, vol. 16, n º 1, 1-24. Recovered of http: // www.uv.es/RELIEVE/v16n1/RELIEVEv16n1_5.htm Boza, Á.; Toscano, M.O; y Méndez, J.M. (2009). The impact of the projects Tics in the organization and the processes of education - learning in the educational centers. Magazine of Educational Investigation, vol. 29, n º 1; 263-289. Recovered of http:// revistas.um.es/rie/article/view/94401/103031
Programme by Network 2019
00. Central Events (Keynotes, EERA-Panel, EERJ Round Table, Invited Sessions)
Network 1. Continuing Professional Development: Learning for Individuals, Leaders, and Organisations
Network 2. Vocational Education and Training (VETNET)
Network 3. Curriculum Innovation
Network 4. Inclusive Education
Network 5. Children and Youth at Risk and Urban Education
Network 6. Open Learning: Media, Environments and Cultures
Network 7. Social Justice and Intercultural Education
Network 8. Research on Health Education
Network 9. Assessment, Evaluation, Testing and Measurement
Network 10. Teacher Education Research
Network 11. Educational Effectiveness and Quality Assurance
Network 12. LISnet - Library and Information Science Network
Network 13. Philosophy of Education
Network 14. Communities, Families and Schooling in Educational Research
Network 15. Research Partnerships in Education
Network 16. ICT in Education and Training
Network 17. Histories of Education
Network 18. Research in Sport Pedagogy
Network 19. Ethnography
Network 20. Research in Innovative Intercultural Learning Environments
Network 22. Research in Higher Education
Network 23. Policy Studies and Politics of Education
Network 24. Mathematics Education Research
Network 25. Research on Children's Rights in Education
Network 26. Educational Leadership
Network 27. Didactics – Learning and Teaching
Network 28. Sociologies of Education
Network 29. Reserach on Arts Education
Network 30. Research on Environmental und Sustainability Education
Network 31. Research on Language and Education (LEd)
Network 32. Organizational Education
Network 33. Gender and Education
Additional Events
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Good news, Twitter users. Your Direct Messages are no longer limited to 140 characters.
As expected, Twitter on Wednesday officially dropped the 140-chacracter Direct Message limit. The new DM limit is 10,000 characters, so you should have more than enough room to say what you need to get out — unless you're really long-winded.
"You can now chat on (and on) in a single Direct Message, and likely still have some characters left over," Twitter Product Manager Sachin Agarwal wrote in a blog post. "While Twitter is largely a public experience, Direct Messages let you have private conversations... Each of the hundreds of millions of Tweets sent across Twitter every day is an opportunity for you to spark a conversation about what's happening in your world."
The change is rolling out now across Twitter's iOS and Android apps, as well as Twitter.com, TweetDeck, and Twitter for Mac. It will continue to roll out worldwide over the next few weeks. If you can't wait to try it out, just head over to the App Store or Google Play to download the latest version of Twitter's app.
Twitter this year introduced several other tweaks for the DM feature, including group DMs and the ability to accept private messages from anyone — even if you don't follow that person.
"Today's change is another big step towards making the private side of Twitter even more powerful and fun," Agarwal said.
Note that this will not affect the public side of Twitter. Tweets are still limited to 140 characters.
Meanwhile, Twitter also this week rolled out a new feature that lets customers of social-tracking service Gnip peruse all public tweets going back nine years. The new Full-Archive Search API, aimed at businesses, would, for instance, let a company analyze previous launch conversations ahead of a new product debut or explore Twitter activity when responding to customer service inquiries.


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Email Us
Unit 5/ 28 Queen Street, Wodonga VIC, 3690
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02 6056 0800
Why Choose Us
Customer Feedback
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Garage Doors in Wodonga
are the garage door experts!
Get a free measure and quote on your new garage door today!
Quality service and customer satisfaction guaranteed
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Albury Wodonga Garage Doors are an accredited dealer for B&D Garage Doors and supplier of an extensive range of garage doors and openers. With over 15 years experience we can provide you with an outstanding garage door solution.
We make choosing a garage door easy, offering a wide range of quality Roller Doors, Panelifts, Security Doors, Automatic Openers, Roller Shutters, Individually Designed Doors and Gate Openers.
Residential Doors
The garage door is an integral part of the design, architecture and security of your home. No matter what sort of garage style or house design you have, there is a garage door that will be perfect for your home.
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We supply, fit and service commercial and industrial doors. Choose from an extensive range of styles and colours. No door is too big or small for the team at
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Has your garage door gone off the rails? Our professional team of technicians can get your garage door back on track. We offer all serving, maintenance and repairs for garage doors & openers.
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Grass protection Mat / Gateway Mat
Grass Protection Rubber Mats
This grass protection rubber mats are an extruded-designed rubber mat intended for the purpose of reinforcement, stabilization and protection of turf and grass. The turf and grass are mostly intended for occasionally trafficked, light vehicle and pedestrian applications.
The rubber mat is very useful in stabilizing grass, and once the grass and root system has grown through the mat a natural look, as well as a more strongly-reinforced grassed surface, creates a very useful and ascetically pleasing grass surface.
Installation Advantages of Grass Protection Rubber Mats
Grass protection rubber mats are unique as it does not require that the existing grass is removed before installation. Other grass and ground reinforcement product rather than grass protection mats on the UK market require the complete removal and reinstallation of the grass area. (This is to provide a very high load capacity which is not attainable by above grass meshes) For applications where heavy vehicles such as semi-trucks or fire engines will not be regularly driving, grass protection mats are an ideal solution which will save on both the installation cost of the project and the overall material cost. For a heavy-duty grass reinforcement solution which is capable of handling heavy loads see our selection of HEAVY DUTY GRASS PROTECTION MAT 1.5m x 1m.
This rubber protection grass mats are intended to be used for light vehicles and pedestrians.
The recommended applications of rubber grass protection include:
Parking space and Access to the Grass Residential
Overflow occasional use parking lots
Golf Cart Paths
Grass Paths
Handicap access paths/Wheelchair
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Here's stuff I want. Feel free to buy me subsets of it periodically, perhaps in alignment with your preferred religious calendar or the accumulation of Gregorian calendar years elapsed since my birth.
Money, Money, Money
Money is good. I can throw money at things as and when they come up.
- Pound sterling, ideally.
Maybe you want me to experience the more tactile thrill of opening a wrapped object of some sort, rather than just collating banknotes like how I imagine the Swiss spend their Christmases.
- Laphroaig whisky
- a cast iron pot
- a large saucepan
- mixology equipment
- a 1 litre Pyrex measuring jug
Perhaps you want to help me further the frontiers of my mind (which, by extension, would imply that you think I am currently insufficiently broadened, which is very hurtful). I can get most books on my Kobo easily (and free-ly), but there are some that—for whatever reasons—aren't a good fit for it and would be better to have in physical Pulped-Tree-O-Vision.
- The First Folio of Shakespeare: In Modern Type (ed. Neil Freeman)
- PoC||GTFO, Volume II (ed. Manul Laphroaig)
- Expect Resistance: A Field Manual (CrimethInc.)
- Tallinn Manual 2.0 on the International Law Applicable to Cyber Operations (Michael N. Schmitt, et al.)
- Composition No. 1 (Marc Sapota)
- How to Bomb the U.S. Gov't (Million Dollar Extreme)
- [Publish Date TBA] The Art of Computer Programming, Volume 1: Fundamental Algorithms (4th ed.) (Donald Knuth)
Or maybe, just maybe, you are beginning to find my nudity overbearing and want to buy me clothes with which to conceal it. Here are those clothes.
- St John Ambulance cufflinks
- Canada Goose coat
- LOOW G3 Boxers
- LOOW socks
- LOOW 220 t-shirt – black
- Black Tie
- Suit. Midnight blue. Peaked lapels and jetted pockets. No vents or double vents. Lapels with black grosgrain facings. Boutonnière hole on lapel. Single-breasted, one button.
- Trousers. Midnight blue. Seam linings grosgrain to match suit facings.
- Waistcoat. Grosgrain to match suit facings. Fastened with shirt studs to match shirt.
- Bow-tie. Black. Butterfly. Grosgrain to match suit facings.
- Socks. Black silk. Calf-length. With sock suspenders.
- Overcoat. Chesterfield.
- Hat. Homburg.
- Gloves. Suede.
- Barbour jacket
I'm still figuring out what bits I need for my next desktop, so expect this list to grow.
- xNT NFC Tag Implantation Kit
- Logitech G X56 HOTAS
- Desktop
- Vikings D8 Workstation
- Boot Firmware: Libreboot
- CPU: 1x Opteron 4284
- Memory: 8 GB
- Power Supply: 650 W Seasonic PRIME Modular 80+ Platinum
- GNU/Linux Distribution: Trisquel
- Main Storage: SSD Crucial 1 TB
- Video Card: GeForce GT 710
- Audio Card: ASUS MIO-AUDIO 892 card
- CD/DVD Drive: No CD/DVD drive
- USB3: USB3 Card TUSB7340
- Vikings D8 Workstation
- Laptop(s)
- X200 Laptop (with non-LED monitor)
- [UNRELEASED] EOMA68 Libre Tea Computer Card
- Other
- SanDisk Extreme PRO 128 GB Solid State Flash Drive
- GoPro HERO7 Black
Get me one of these and I'll be set for a year.
- Nature
- Science
- Adbusters
- ;login:
- National Geographic


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Wall Street's Retreat Caps Gains in Europe's Markets
Share prices moved mostly higher across Europe Tuesday, although some markets lost ground as prices opened lower on Wall Street.
Some investors in the U.S. moved to cash in gains after Monday's nearly 75 point rise in the Dow Jones Industrial Average. Profit-taking in New York led to selling in London, after shares reached an all-time high in midmorning trading.
To Read the Full Story


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8 Arlington Dog Parks, Ranked
The county has eight sanctioned off-leash dog parks. We break them down for you with the help of our canine critic, Pepe.
Your furry friend is getting a bit restless and needs to release some energy. Luckily, Arlington County has eight officially sanctioned off-leash dog parks where pups can run, play, smell other dogs and fetch that grimy tennis ball to their little heart's content.
For the lowdown on these offerings, we recruited the help of Pepe, a 2-year-old chihuahua/pinscher mix adopted from the Animal Welfare League of Arlington who now lives in Rosslyn. He tested each park and offers his reviews.
Note: There are important rules and regulations to heed in all Arlington County dog parks. All dogs must be licensed and older than four months, and poop must be picked up. Each of the parks below closes 30 minutes after sunset with the exception of Fort Bernard (9 p.m.) and Towers Park, which has lights and stays open until 10 p.m.
#8 Benjamin Banneker Dog Park
Address: 1680 N. Sycamore Street
Sponsor Group: Banneker Dogs
Size: Moderate; part of the 11-acre Banneker Park.
Parking: A medium-size parking lot is available. There are "no parking" signs in the neighborhood, so street parking is not an option.
Defining Feature: Renovations are pending. Last May, the community voted on design details for a new renovated park that's estimated to open by the end of 2019, featuring synthetic grass, an ADA-accessible entrance and a concrete splash pad for pups.
Pepe's Take: "I'm excited for the renovations though I'm partial to natural grass. I do like that this place has a separate small dog park. Sometimes big dogs can be too much for me to handle."


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Jamie and Jimmy get ready for battle
Following the success of its first series, Jamie & Jimmy's Food Fight Club returns for a fresh round of amazing food adventures.
From their HQ – a café at the end of Southend pier – Jamie and Jimmy will be celebrating, exploring and recreating more of Britain's diverse food heritage and cooking up incredible dishes to try at home.
Each week the Essex boys will be inviting a celebrity guest to earn their foodie stripes by working in the café's kitchen, cooking and serving the dish of the day.
And the boys will be firing up the Capri again, hitting the road on a mission to bring some of Britain's forgotten foods back to life. Plus there's a weekly 'blow-out' recipe with real wow factor from Jamie and Jimmy gets his hands dirty on a DIY food builds.
Made by Fresh One Productions, the new 4×60' series of Jamie and Jimmy's Food Fight Club was ordered by Rich Evans, Factual Entertainment Commissioning Editor at Channel 4 and will be executive produced by Dermot Caulfield and Zoe Collins. The series will air in early 2014.
Of the commission Jamie Oliver said:
"I can't tell you how thrilled I am to be getting back on the road with my old mate Jimmy for another round of Food Fight Club. Once again we'll be relying on our trusty Ford Capri to take us around the country, but this time we're in search of incredible, but forgotten British dishes and ingredients as we try to get them back on the nation's plates.
We'll also be returning to our café on Southend pier, where we'll be inviting both locals and celebrity guests to come and join in the fun – I'll be cooking up some big, bold, show-stopping recipes for you to try at home and Jimmy will be doing what he does best, tearing it up with his usual foodie-science experiments.
Food Fight Club is all about exploring, eating and celebrating great British food, and encouraging as many people as possible to get involved and enjoy it too – if that's not worth fighting for, I don't know what is."
Jimmy Doherty added: "It's amazing to be back filming the second series. Last year we showed that our food is some of the best in the world and this year we're on a massive road trip to fight for the lost and extinct food treasures of Britain and bring them back with a bang."
Rich Evans said "We're thrilled the boys are getting together again for another series of Food Fight Club, combining road trip adventures with money-can't-buy food events in their pop-up café on Southend pier."


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Panel Puncher's, Matt and Adam, discuss the best movie for the post Nolan-verse DC franchise! Throw Down & Level Up! Have a feature suggestion or questions for your hosts? Drop us a line at email@example.com. Wanna keep up with what we're playing? … Continue reading
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Ep. 56: Beer Tasting and Podcasting
Cheers from The Nerdgasm Podcast. This week we bring you a slightly more imbibed version of the podcast, rich with #InterestingGamertag's, video game news across all platforms and a discussion on DC's superhero movie lineup. Mike Votto, "frequent contributor" … Continue reading


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Travel To School And Urban Structure In Medium And Small Sized Cities: A Case Study Of Castelo Branco
Free (open access)
Page Range
341 - 352
3,155 kb
Paper DOI
WIT Press
R. M. Alves, S. A. Duarte & M. I. Calcinha
Journeys from home to school represent a significant portion of all urban commuting. A high number of citizens are involved. Not only students but parents, relatives, friends and individuals make up this group. These journeys have a relevant impact on urban environments because they correspond to the time (Peak Hour) and the spatial needs of other kinds of journeys that apply to other types of families and activities. The aim of this paper is to relate the urban zone with modal split of four schools in a medium sized Portuguese city, in aggregate form by school and by grades. These schools include children and adolescents from the 1st grade until 9th grade in a group age of 6-10 (1st - 4th grade), 10-11 (5th-6th grade) and 12-14 years old (7th - 9th grade). The differences between mobility patterns in journeys to/from school by school and by grade are evident. Walking is the main travel to school mode choice in three schools and driving in one school. Driving is the main travel to school mode choice for the students from the 1st to 6th grades and walking for the students from 7th to 9th grades. According to the results, the urban zone influences the mobility patterns in journeys to/from school, however for small and medium sized city that influence does not appear to be so evident. Keywords: built environment, scholar mobility patterns, medium and small sized cities, children, students and adolescents. 1 Introduction Several countries place particular importance on promoting sustainable urban mobility policies and physical activity on to/from school journeys. Through programs, information and awareness campaigns, targeted at students and
built environment, scholar mobility patterns, medium and small sized cities, children, students and adolescents


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Jose Basulto Quotes
3 Jose Basulto quotes:
"The level of penetration is worse than people realize. (Castro operatives) work within Miami's community, creating disinformation, inciting violence at peaceful exile protests to make us look bad in the press."
"That's what good spies do. They blend in and make friends."
"I think the cartoon says a lot about what happened to our psyche after Castro took power and established a society based on double morality."


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Defender Stephane Zubar will tomorrow get another chance to earn a contract with Dundee United.
The 29-year-old former Bournemouth man impressed during a trial a couple of weeks back and turned out in the closed-door friendly win over Cove Rangers.
Now he's returning north to take part when the Tangerines face Blackpool, again behind closed doors, tomorrow.
Zubar has also been interesting a number of clubs down south, including the Seasiders.
Meanwhile, young Scottish defender Zak Jules will not be coming on trial.
New Reading boss Jaap Stam has decided to hang on to the 19-year-old after he impressed in pre-season training.


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Hundreds of anti-Israel protesters were heckled by a large contingent of Israel supporters as they marched through the streets of central London on Sunday for the annual Iran-initiated Al Quds Day march.
Later, the crowds grew as the pro-Palestinian group left their position in front of Saudi Arabia's embassy and began marching toward No 10 Downing St, the office and home of the British prime minister.
Unlike in previous years, around 200 people waving Palestinian flags and holding signs with anti-Israel slogans were almost equally matched to a crowd of opponents who gathered nearby behind a banner that read 'free Gaza from Hamas,' according to witnesses.
The two sides were separated by a hefty police presence. A third group consisting of supporters of the anti-Islam and anti-immigration English Defence League and allied groups had also joined the fray, but were cordoned off by police.
As the group wove toward Downing St, they were briefly blocked by a group of counter-protesters who were waving Israeli flags and chanted that their opponents were "terrorist scum." They moved on at the request of police.
A flag of the Shiite militia Hezbollah was flown by at least one of the participants in the Al Quds Day rally.
The full text can be found on i24 published on 10 June 2018.