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A new population-based study showed that novel oral androgen signaling–inhibitor therapies may be associated with an increased risk of death in patients with preexisting cardiovascular conditions. The research was published by Lu-Yao et al in European Urology.
"Data from published clinical trials revealed a small but significant increase in the incidence of cardiovascular toxicity in patients treated with androgen-deprivation therapy," said corresponding study author Grace Lu-Yao, PhD, MPH. "However, little was known about the short-term mortality in men with cardiovascular risk factors treated with these novel oral androgen signaling–inhibitor therapies, especially among patients who did not qualify for clinical trials."
"This study fills that major knowledge gap: what are the clinical outcomes of men with advanced prostate cancer and preexisting cardiovascular conditions treated with these novel oral androgen inhibitor therapies? The outcomes of this study provide new relevant data to facilitate patient-physician discussions about the risks and benefits of treatment for men with advanced prostate cancer," she continued.
Men with advanced prostate cancer that progressed on androgen-deprivation therapy are typically treated with novel androgen signaling–inhibitor therapies such as abiraterone acetate and enzalutamide. Many of the pivotal studies which led to the approval of these therapies excluded men with multiple cardiovascular comorbidities. As a result, the risk in these patients is poorly understood.
In order to explore this question, researchers conducted a large-scale population-based study. The team examined data from 3,876 patients with advanced prostate cancer collected in the Surveillance, Epidemiology, and End Results (SEER) database. Sixty-seven percent of the men treated with abiraterone acetate or enzalutamide had at least one preexisting cardiovascular condition—such as congestive heart failure, acute myocardial infarction, stroke, atrial fibrillation, and ischemic heart disease—in addition to prostate cancer.
The results showed a higher 6-month mortality after starting androgen-inhibition therapy in patients who had preexisting cardiovascular conditions.
To explore that result in finer detail, the researchers examined the outcomes by chemotherapy use. They found that compared to patients receiving the same therapy for prostate cancer without preexisting cardiovascular conditions, those with at least three heart conditions had a 43% increase in the relative risk of 6-month mortality (if they had chemotherapy before using the oral androgen signaling–inhibitor therapy) and a 56% increase in the relative risk of 6-month mortality among patients without documented chemotherapy use. In essence, having three or more preexisting cardiovascular conditions was associated with roughly a 50% increase in mortality.
In addition, the researchers examined changes in hospitalization rates following the use of the two oral androgen inhibitors. Among the no-chemotherapy group, abiraterone acetate was associated with an increase in posttreatment hospitalization, but the same pattern was not observed in patients treated with enzalutamide. Among patients with at least three preexisting cardiovascular conditions and no history of chemotherapy, enzalutamide was associated with a 41% lower posttreatment hospitalization rate compared to abiraterone acetate.
The researchers found that abiraterone acetate is associated with increased hospitalizations in patients taking various classes of medications. "In addition to blocking androgen synthesis, abiraterone acetate may interact with many drugs and lead to higher risk of toxicity from a wide range of other medications," said Dr. Lu-Yao. "Further studies are warranted to understand the potential mechanisms underlying the observations."
In response to the study's findings, researchers are working with cardiologists to monitor the risk of adverse cardiovascular events and develop alternative treatment strategies.
Disclosures: This project was supported in part by the Department of Health of Pennsylvania, the National Institutes of Health/National Cancer Institute, and the Sidney Kimmel Cancer Center Biostatistics Shared Resource. For full disclosures of the study authors, visit europeanurology.com.
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.
The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.


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Clementine Long Sleeve Gown & Bonnet
Handmade in the USAThe Clementine heirloom long sleeve cotton Christening Gown is a stunning gown for your baby girl's christening or blessing! Designed with rich 100% cotton interlock in ivory, it is overlaid with embroidered mesh featuring a gorgeous vintage border floral pattern with a cute embroidered flower detail on the neck. Cotton scalloped lace accent the sleeves, hem lining, and neck. She will look so beautiful, everyone will surely think her baptism gown has been in the family for years!
- 100% cotton interlock in ivory
- Embroidered mesh featuring a gorgeous vintage border floral pattern
- Cotton scalloped lace
- Pink flower and green leaf embroidery
- Shell buttons
Details & Care
- All of our items are made with delicate raw silks, cottons, linens, and ribbons, which have not been chemically treated
- We highly recommend dry-cleaning all of our items after wear to help keep the materials in their original shape, texture and color
- We do not recommend using water to clean pieces made with silk, as it will affect the color and texture of the material, as well as cause the material to lose its natural sheen
- If you choose to hand wash your cotton items, use a very mild detergent and rinse items well. Keep in mind that water, heat and detergents can affect the shape, texture and color of the items and materials. Hang garments to dry, but avoid direct sunlight as this can discolor the materials
Real Customer Style
Heirlooms Made in the USA
Our emphasis on finding the softest and highest quality materials for the little one wearing them, along with superior craftsmanship, creates outfits that are not only worn for one day - they are cherished and passed down for years to come.
Made in the USA
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Customer Reviews
I needed this dress next day and across the country at that and they made sure it got to me in time it even arrived 2 hours before originally promised the dress was beautiful.
This gown was everything we hoped for! Our fourth daughter to wear one of their gowns and we loved it! Gorgeous and high quality as always!
Beautiful and well made! Fit my daughter perfectly!
The christening gown looked wonderful and as expected! It arrived perfectly packaged Thank you for this wonderful gown, I was so excited to dress my baby in it for her special day!
This dress is simply beautiful. Thank you for working with me!

subset: commoncrawl


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There's an old Jewish proverb that that says- " A mother understands what a child does not say."
Nothing could ring more true, after events of the past days, whereby we learned of an urgent night court sitting to determine whether a health board's decision not to do surgery on a terminally ill boy would amount to homicide. Thankfully, the judge did not rule this way and the decision to turn off the frail 7yr old boys life support was made.
I could imagine nothing worse than having to make this heart wrenching decision for whatever reason, but to have watched your child suffer in silence through out their life I could imagine nothing worse. The boy's older sibling had also died after a long battle with the same rare disease. As the years passed, the condition began to cause irreversible damage to various organs. By the end, both were bedridden, unable to speak and in immense pain.
This mothers life was devoted to caring for her sick and frail children, every living breath of it. In October of last year, the lad had a feeding tube inserted because he could no longer swallow food or medication. Earlier this month, the tube became dislodged and the only solution was to operate. doctors said that without it he would die within days.
Senior doctors, nurses and a hospital ethics committee were unanimous that the tube should not be reinserted. So too, was the boys mother. The boys only form of communication was by flicker of an eye movement, but through all this pain and suffering, she knew and understood him. she said in her affidavit, read to the court; "He often screams out in pain. He is extremely fragile. He is uncomfortable if he is slightly too hot or cold. Passing urine and bowel movements hurt him. When he is being fed, the pain worsens horrendously due to acid reflux." She said she was distressed about the intention to keep feeding him when she had seen him in chronic agony. A hospital director told the court that the mother was a "wonderful carer of her child, a child who she loves dearly."
Justice Jill Mallon said she was satisfied it was not in the boy's interest to have the operation and it would go against good medical practice. "It would be prolonging the dying period when … death is closing in. The operation will defer death, but not for long.
The boy departed this world the next day, to a better place, of that I am sure. The question is simply this..
Who knows best?


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Remembering Moors Murderer Ian Brady's five victims who he killed and dumped with Myra Hindley during campaign of horror
The 79-year-old serial killer died earlier this evening
MOORS murderer Ian Brady has died at the age of 79, just hours after he was urged to "do the right thing" and reveal where the last of his child victims is buried.
The sick killer refused to do so however.
A Mersey Care NHS Foundation Trust spokesman said: "We can confirm a 79-year-old patient in long term care at Ashworth High Secure Hospital has died after becoming physically unwell."
The serial killer, who used the name Ian Stewart-Brady before his death, was a patient at Ashworth Hospital on Merseyside where he was reportedly receiving palliative care.
Twisted Brady and Myra Hindley, who died in prison in 2002, tortured and murdered five children in the 1960s.
Here, we remember their tragic victims.
Pauline Reade
On July 12, 1963, Brady told Hindley he wanted to "commit his perfect murder".
He told her to drive a van around the local area while he followed on his motorbike.
After spotting Pauline Reade, 16, the couple stopped and Hindley asked her if she would help her locate an expensive glove she had lost on the Moor.
Hindley claimed Brady then took Pauline on to the Moor, where he slashed her throat twice and sexually assaulted her.
Brady claims that Hindley helped.
John Kilbride
On November 23, 1963, Hindley approached John Kilbride in Ashton-under-Lyne, Lancs, and offered him a lift home.
Brady told the 12-year-old he would give him some sherry, but they would have to make a detour on the Moor first.
He sexually assaulted the youngster and attempted to slit his throat with a six-inch serrated blade before fatally strangling him with a piece of string.
Keith Bennett
Keith Bennett, 12, was on his way to his grandmother's house on June 16, 1964, when Hindley lured him into her van.
She drove to a lay-by on the Moor and Brady took the boy while Hindley kept watch.
Brady reappeared 30 minutes later having sexually assaulted and strangled Keith.
His body was never found.
Lesley Ann Downey
In search of another victim, the couple visited a fairground on Boxing Day, 1964, and came across Lesley Ann Downey.
They approached the 10-year-old and lured her back to their house, where she was undressed, gagged and forced to pose for photographs before being raped and killed.
The following morning Brady and Hindley drove with Downey's body to Saddleworth Moor, where she was buried, naked with her clothes at her feet, in a shallow grave.
Edward Evans
On 6 October 1965 Brady met 17-year-old apprentice engineer Edward Evans at Manchester Central railway station.
He invited him to his home where Brady beat him to death with an axe.


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True Value Company, one of the world's largest hardlines wholesalers with more than 4,400 independent retailers in over 60 countries, is looking for Merchandise Handlers for our 1st shift at our Westlake/ Cleveland Distribution Center.
Scheduled Days: Monday through Friday Hours: 11am to 7:30pm
Starting Hourly Rate: $14.75 to $16.36 per hour *** based on skills and qualifications **
Our Merchandise Handlers are responsible for safely unloading merchandise from trailers, lifting cartons and product, and checking goods received against purchase orders or invoices. You are also responsible for loading cartons on pallets and other containers for outbound shipment. Stocking shelves with goods received while accurately maintaining records of goods received or shipped is also part of the job.
You may be responsible for operating power equipment; using small hand tools, pallet handlers and hand trucks. True Value selects merchandise with the latest voice-pick technology to ensure accuracy and quality.
Position Description
The effective Merchandise Handler performs the following tasks safely with the customer in mind:
Position Qualifications
A successful team member possesses the following qualifications:
Physical Requirements:


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Brick Cladding Systems
Brick slip cladding systems are proven in projects across a wide range of sectors, from residential to retail, in both the public and private sector. Whether you require retrofit or modern methods of construction, our cost-effective cladding solutions provide traditional aesthetics and durable performance for the lifetime of your building.
Gebrik Brick Cladding System
Gebrik consists of approx 700 different natural clay brick slips, in a range of sizes, cast in polyurethane under factory controlled conditions. Non load-bearing, lightweight stretcher, stack or flemish bond panels are produced to create approx 1m² 'sheets' which can be screwed directly to either masonry, timber or steel frame substrates on site. With a full range of factory-produced or site-applied components to suit external corners, surrounds to window or door openings and any other abutments, the system can cater for most architectural designs. In fact, it could be said that as the system is not load-bearing the limits to use of the system are restricted only by the architect's imagination.
Latest Time-Lapses
These time-lapse videos show different constructions of our projects, then finished in Gebrik Brick Cladding


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Algae genome could aid medical, climate research
A ubiquitous phytoplankton found in oceans around the world could hold the key to fields ranging from climatology to dentistry, since a team of scientists led by Cal State San Marcos researchers unlocked the genomes for 14 different strains of the algae.
Their findings, published last week in the journal Nature, decoded the DNA of related strains of the algae Emiliania huxleyi. Their study is one of only a handful to unravel the genomes of marine algae and the first ever to document a pan genome - a set of core genes shared by diverse algal varieties.
"It's still very rare to have a whole genome sequence for any marine phytoplankton," said Sonya Dyhrman, a professor of microbial oceanography at Columbia University and a co-author of the study. "It's absolutely unprecedented to have multiple strains of the same species sequenced."
While the different strains share 70 to 80 percent of their DNA, about 20 to 30 percent of their genes are unique to each strain. That diversity allows them to inhabit virtually all the world's oceans except the polar seas, said lead author Betsy Read, a professor of molecular cell biology at CSUSM.
"They have this tremendous ability to adapt," she said. "This is why we can pull them from almost every bucket of water in the ocean."
Read released the findings in the journal Nature last week, in collaboration with CSUSM computer science professor Xiaoyu Zhang, Dyhrman and about two dozen co-authors from a far-flung network of institutions in the United States, Germany, England, France.
The findings, Dyhrman said, are as valuable to microbiology as decryption of the human genome has proven to medicine.
"Any time you unlock that code, it gives you this Rosetta stone to understand how that organism works and how it interacts with its environment," she said.
The algae are the third most abundant phytoplankton, and are a key component of the ocean food chain, nourishing animals including crustaceans, shellfish and other filter feeders.
They're characterized by their intricate shells, composed of interwoven lattices of calcium carbonate.
"We kind of think of them as flowers of the ocean," Read said.
Those shells reflect light, tinting the ocean surface a milky turquoise shade and leaving chalky remains. The White Cliffs of Dover owe their pale hue to fossilized remains of the algae. Their massive blooms spread across hundreds of thousands of square kilometers of the ocean, rendering them visible in satellite photos.
"They're arguably the most important species you can see from outer space, because of the light reflecting properties of its shell," Read said.
The creatures absorb calcium dioxide to build their shells, playing a crucial role in the global carbon cycle. The family of phytoplankton they belong to can account for 20 percent of total carbon fixation in some systems, the study stated. In addition, the organic sulfur compounds that E huxleyi release are known to seed clouds and could influence weather, researchers said.
"It fixes carbon for energy and its shell, but also releases carbon," Read said, noting that scientists are examining the balance between its carbon use and carbon emissions.
"E. huxleyi represents one of the most cosmopolitan phytoplankton in the world's oceans," said Christopher Gobler, a professor of marine and atmospheric sciences at Stony Brook University in New York, who published the genome for a separate variety of marine algae in 2011. "They're very, very important on the global scale for controlling the earth's carbon budget."
Their genome could reveal ways to monitor carbon dioxide in the atmosphere and ocean by identifying the genes that trigger processes such as photosynthesis and calcification. And it can help scientists study, through "hind-casting," the role the algae played in climate during other geologic periods, Dyhrman said.
The algae's genetic blueprint could also inspire innovation in medicine and technology. Their natural light-reflecting properties could illuminate development of optoelectronics - devices that produce or control light - Read said.
And their shell-forming process could pave the way for calcium-based biomedical devices, such as joint replacements or dental implants. It could also help explain the healthy calcification that happens during bone growth, as well the unhealthy calcium deposits that occur in conditions such as kidney stones and heart disease.
"Knowing the genes and proteins opens up more waves of research to answer these questions," Read said.
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Here's a part often overlooked yet extremely important if you're restoring your Sprite interior.
Original Bugeyes had a thin, black, wooden spacer under the driver seat, to shim the seat up so it would clear the longitudinal member welded beneath the seat. With the thin rubber mats that came with the car, this original spacer provided an adequate gap and allowed easy movement of the seat frame fore and aft. But with the advent of thicker carpet in Bugeye interiors, the original thin spacer no longer works. Even if you don't move your seat often, with original thin spacers, it's very difficult to install your seat on modern carpet.
We have fixed these issues with an improved product… our thicker seat spacer makes installation of your seats easier, and allows better clearance between the seat frame and the floor pan.
This is a Bugeyeguy exclusive, not available anywhere else. Every Bugeye needs a least one pair. And if you have two adjustable seats, you need two pairs! (stock Bugeyes had a fixed passenger seat that requires no wood, but many have been changed to adjustable)
Click here to check out this innovation (and others) by visiting our catalog!


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Orange County Sheriff's Office and Orange County Schools are teaming up to possibly change safety policies in response to last month's school shooting in Parkland, Fla.
"Each time there is an incident, even though we may not be directly involved, we certainly review any of our plans that we have in place and look at ways we can more effectively address concerns to ensure our school system finds best ways to increase the safety if its measure," said Patrick Abele, chief operations officer for the school district.
The county is no stranger to emergency situations with active shooters, said Sheriff Charles Blackwood, and they are ready to respond whether the threat is at a shopping mall, a private residence or a school.
The school district already does lockdown training with staff every year and is also starting to do emergency preparedness drills throughout the year, but Blackwood said he is also working with the fire department to change the way they respond to fire alarms in schools, in light of the Florida shooting.
"Since I was in the first grade, when the alarm goes you line up you get out the door. Right now. Fast," Blackwood said. "Would four or five seconds really matter? Well, it would have for those children in Florida. If they'd have stayed in that school room instead of running out in the hallway when the alarm went off, many of them would be here today."


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1 Lawyer
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The Modern Law Library
Posted May 17, 2017 08:41 am CDT
Almost 30 years before Linda Brown and her parents took on the Topeka Board of Education in Brown v. Board of Education, Martha Lum's parents Jeu Gong and Katherine sued to try to stop Rosedale, Mississippi, from barring their Chinese-American children from the local "white" school. Their case, Gong Lum v. Rice, made it to the U.S. Supreme Court in 1927. But rather than granting them relief, the unanimous U.S. Supreme Court decision led to even stricter school segregation.
For this episode of the Modern Law Library, in honor of Asian Pacific American Heritage Month, the ABA Journal's Lee Rawles discusses this little-known chapter of history with Adrienne Berard. Berard is the author of Water Tossing Boulders: How a Family of Chinese Immigrants Led the First Fight to Desegregate Schools in the Jim Crow South. Berard discusses the bravery of the family's decision, and the complicated state of race relations in 1920s Mississippi in which the debate over whether the "colored" category applied to Asian-Americans took place. We also discuss Earl Brewer, a former governor of Mississippi, who took the Lums' case in a bid to regain his reputation, and how the immigration debates of the early 20th century have ugly echoes in today's political environment.
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Strange to see a city so quiet.
36.167114 -115.149334
Strange to see a city so quiet.
Tips for continuing your search for love during social distancing
How I'm coping with isolation
What crazy stories do you remember from your holidays?
A purring pickpocket
Sometimes faster is not better!
After a few months off to get settled...I'm back!
There's always an interesting person you meet on vacation.
Fandango's One-Word Challenge - "Extra"
One of the many reasons I love the blogging community is a special surprise like this.


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David Hurn exhibiting at the Big Little City project
By Daniel Green on 05/06/2011
Legendary Magnum photographer, David Hurn, has a collection of work prints taken in Cardiff over the last few decades exhibiting at the Big Little City exhibition. His work will be up until Sunday 19th June, so come on down to take a look. Links : Big Little City website Magnum – David Hurn profile Wikipedia […]
Posted in News, Photos | Tagged biglittlecity, Cardiff, cardiffart, cardiffartproject, cardiffphotography, dangreen, dangreenphotography, davidhurn, magnum, magnumphotography, photography, welshphotography | Leave a response
Read all about it!
By Daniel Green on 01/06/2011
Posted in News, Photos | Tagged art, biglittlecity, Cardiff, cardiffart, cardiffartproject, cardiffcharacters, cardiffmuseum, cardiffphotography, dangreen, dangreenphotography, echo, photography | Leave a response


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Report Shows America's state-by-state health rankings
January 12, 2017
- Industry News
- All States
- Fully Insured and Self-Funded
United Health Foundation recently released the 27th America's Health Rankings Annual Report. As the longest-running annual assessment of the nation's health on a state-by-state basis, the report showcases positive trends in the health of the nation as well as concerning upticks in several key indicators.
Among the report's key findings:
- Many Americans are experiencing improvements in their overall health and well-being, with long-term declines seen in the prevalence of smoking, the rate of preventable hospitalizations among Medicare enrollees, and percentage of the uninsured population.
- For the first time in the 27-year history of the America's Health Rankings Annual Report, the cardiovascular death rate has increased in the past year. The report also found increases in the rate of drug deaths and a continued high prevalence of obesity.
- Hawaii ranks as nation's healthiest state for the fifth straight year, followed by Massachusetts (2), Connecticut (3), Minnesota (4) and Vermont (5). Mississippi drops from 49th to 50th this year, moving Louisiana out of the bottom position to 49th.
Please refer to the enhanced America's Health Rankings website for additional tools, resources and data.


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RE: The DEA Ruling
Dear Friends,
Many of you have expressed concern over the recent DEA ruling that
intends to schedule all Cannabis extracts and cannabinoids as Schedule 1 drugs.
The DEA does not have the authority to change or make laws.
This role is reserved strictly for Congress.
The 2014 Farm Bill emphatically mandates that industrial hemp grown as part of state sanctioned pilot programs is exempted from the Controlled Substance Act and that federal agencies (such as the DEA) are prohibited from interfering with pilot programs and/or the interstate sale or transport of hemp products.
Importantly, and aside from the issue of legality and the Constitutional separation of powers, Congress has expressly forbidden any Federal funds from being used to "prohibit the transportation, processing, sale or use of industrial hemp that is grown or cultivated in accordance with section 7606 of the Agricultural Act of 2014, within or outside the State in which the industrial hemp is grown or cultivated"–Section 763 of the Omnibus Appropriations Act of 2016 (Pt. 114-113) passed on December 18, 2015 ("the Funding Act"). Unless and until this provision lapses and is not renewed, the DEA and the DOJ are prohibited from using any Federal funds to enforce any laws (or rules) that would interfere with hemp (or its products) that are lawfully cultivated under state law in accordance with the 2014 Farm Bill. This means that even if the DEA's new ruling was lawful, they can't enforce it. The 9th Circuit Court of Appeals ruled that the DOJ was prohibited from using Federal funds to interfere with a State's medical marijuana program by prosecuting state compliant medical marijuana users based on a similar funding clause — USA v. McIntosh, 833 F.3d 1163 (9th Cir. Cal. 2016) ("McIntosh")
In addition, since the 9th Circuit Court of Appeals ruling in the US Hemp Association vs. DEA, it is legal to import foreign grown hemp products.
Please help to secure passage of the Industrial Hemp Farming Act in the next Congress, a step which would once and for all remove any ambiguity and de-schedule CBD and other non-psychoactive cannabinoids.
Ask your representative to co-sponsor house bill "H.R.1635": http://www.house.gov/representatives
Ask your senators to co-sponsor the senate companion bill "S.1333":
Please continue to educate friends and family about the life changing benefits of non-psychoactive cannabinoids and request that they also contact their Congressmen and women.
American Shaman CBD will continue our part in educating and fighting to insure everyone has access to the CBD products they need. We believe in our product and will be operating our business "as usual".
Thank you,
Vince Sanders, CEO
If you are not 100% satisfied with your purchase, within 45 days of the purchase date, we will fully refund the cost of your order. We take your privacy seriously and will take all measures to protect your personal information. Any personal information received will only be used to fill your order. We will not sell or redistribute your information to anyone.
FDA Disclaimer: Any statements made within this website have not been evaluated by the Food and Drug Administration. No products produced, manufactured, marketed, or distributed are intended to diagnose, treat, cure or prevent any disease. Consult your physician before beginning any supplements or botanical extracts. If pregnant or breast feeding, consult with your physician before use. For use by adults 18+. Keep out of reach of children.


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Verdict: An intelligent revenge saga!
Kathakali is touted to be based on a real life incident that happened with Pandiraj (Producer – Director) friend. Vishal and Pandiraj joined together to produce this whoddunit thriller, where one is a hero-producer and the other is a director-cum-producer. This shows the confidence these guys have in their script. Let's see if the outcome is as great as they have visualized.
Movie starts with a fight between the gangs of the Kakinada fishermen and Vizag fishermen. All the antagonists are introduced in the opening titles amidst a terrific background score by Hiphop Tamizha. The leader of Kakinada fisherman gang, Sambasiva (Madhusudhan) is a ruthless crook who does anything to wrench power. He becomes a pioneer of illegal trade and in return becomes an enemy to many people across the state. Kamalakar (Vishal) returns from US to marry his lady love Malleswari (Catherine Teresa) after four years. With their marriage due in four days, Kamalakar goes to Vizag to invite his friends for marriage and meet his lady love. In the meanwhile, Samba is murdered in broad day-light in the streets of Kakinada which results in a curfew like situation. All fingers point towards Kamalakar family as the reason for Samba's murder due to their previous enmity. Who killed Samba and what is the connection between Kamalakar family and Samba and did Kamalakar marry Malleswari forms the rest of the story.
Vishal as a US return guy was apt in the role of Kamalakar. Catherin Teresa as Malleswari is cute and bubbly. The chemistry between the lead pair is awesome. Madhusudhan as Samba is outstanding in the role of an antagonist. One can easily relate him to the conniving nature and should be commendable in the way he portrayed his character. Sreejith Ravi as inspector is another surprising element in this movie who is someone to watch out for in future. Karunas as Vishal friend provided some good comedy. All the other supporting cast are adequate.
Pandiraj has to be applauded for putting his heart and soul into the movie, and for coming up with an authentic thriller and Vishal needs to be commended for his guts for successfully attempting a thriller. Hiphop Thamizha's background score and music is a treat to ears. Balasubramaniam's photography is excellent. The visuals in night scenes and rain fights are praise worthy. Editing and screenplay is crisp, like any other good thriller movies. Production value is good, which one may have found difficult it is actually a dubbed movie. They have taken all care to show all the background hoardings in native Telugu language.
Why You Should Watch This Movie:
Audience have always been positive to whodunit thrillers and mystery movies, even if made by a smaller hero and production team. In this hot summer, this flick will send shivers down your spine. So chill and grab a ticket this weekend at a theater near you.
— By Ajay Mudunuri


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Essie Nail Polish
- Essie is the ultimate color authority offering a line of superior nail polishes.
- Fashion-forward shades with an exclusive award winning formula are always classic, chic and elegant.
- Flawless coverage along with outstanding durability, a chip-resistant formula and whimsical names in the most up-to-the-minute colors.
- DBP, toluene, and formaldehyde free.
- To use:
- Apply a thin layer of your favorite essie base coat or solution followed by 2 coats of essie polish.
- Finish with your favorite Essie top coat for a super shiny, chip resistant manicure that will be dry in a flash.
- Made in USA!
- .46 oz.
4 Reviews Hide Reviews Show Reviews
Essie Nail Product
Fast, easy deliver! So happy with the product & service!!
Wonderful nail polish
Great color!
Essie polishes
The Essie polishes purchased are Christmas gifts - Essie was requested by both daughters
Beyond Cozy
Just the prettiest color but not the best for longevity. I pretty much never expect more than an evening (a full day if I put on a couple layers of clear topcoat) out of it but I dont even care because its just the best sparkle. Somewhere between a silver and a pale gold, super full coverage tiny glitter, grainy almost matte/sand texture and finish. I have worn it with botha shiny and matte topcoat and it looks great both ways. The formula is a little bit thick and can get gloppy which makes it harder to apply for me since i have super small nails. A great special event polish.


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I was as shocked as you probably are right now. But this is definitely worth checking out. Perhaps we'll see these guys become great musicians in a few years and go on to have a long, rewarding career. Right now, I would put them in the top three of greatest Radiohead cover bands. Am I being serious or sarcastic? IT'S. UP_ TO. YOU!
Did you get that? Remember the whole 'In Rainbows' website with the different colors and…the fonts were like that…with the spacing…*sigh*
Anyhow, here's their live take on 'Optimistic.'


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Junior Trawlers
2020 Winter Competitions!
It's that time of year again and we are back in action! We are now taking nominations for our winter competitions starting the 20th July.
Come along and get involved in our fun action packed competitions including Monday night basketball, Tuesday night futsal and Mother & Child Basketball and Thursday night ladies & mixed netball!
Get in early to secure your teams spot in the social, high paced & exciting environment that is indoor sports!
Play in 2 or more of our competitions for just $250 for seniors or $140 for juniors! Just come and see the RLSC staff!
See you on the courts!


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People from all over the country started to show up on the Friday night before the concert. Widespread Panic had asked their fans to bring food for the Northeast Georgia Food Bank, and one fan from Oregon had 151 pounds of locally-processed chicken delivered to the bank after being told their biggest need was meat. Sandy Creek Park provided camp grounds for fans, and ran shuttles from the park to downtown. The day of the show, bass player Dave Schools told the Banner-Herald that he was happy with the turnout, seeing all the people in town, because "there's a time, when you're young, when it's important to travel around and throw caution to the wind."
The city and band expected somewhere between 15,000 and 35,000 people to come to town. Total turnout was much higher than anticipated, with estimates from police that there were 70,000 people by the time the concert ended. Some organizers thought the turnout was closer to 100,000. It is considered the biggest album release party in history. Among resident concert-goers were Mayor O'Looney, UGA President Michael Adams and his family, and then-Commissioner John Barrow.
Widespread Panic did not want their event to be disruptive to other, previously scheduled events on the 18th. They asked their fans near the stage to be quiet between 6:45pm and the 8pm scheduled start of the show, out of respect for the wedding between Mary Carroll Dillard and Taylor Murray at 7pm at the First United Methodist Church on Lumpkin Street, across from the stage. According to then-Commissioner Doc Eldridge, who was a guest at the service, "Inside the church, you would never have known there were 70,000 people outside." When the bride and groom emerged from the church, hundreds applauded for them.
The band met as students at the University of Georgia, and consider Athens their home. Widespread Panic are longtime underwriters of the local public radio station, WUGA, and wanted the concert to be a gift to their hometown. They had approached then-Mayor Gwen O'Looney in January, 1998, about having the free concert release party in downtown Athens, and had her support. Though Mayor O'Looney was a member of the Athens-Clarke County Downtown Development Authority that would provide some funding for downtown festivals and events, it was the City Manager who had the responsibility to review and approve any special events permits.
The City Manager at the time, Al Crace, was concerned about public sanitation and protection costs to the county. It wasn't until the band's record company, Capricorn Records, and the band itself put up most of the money for the event that the permit was approved, just eight days before the show was scheduled. The Downtown Development Authority used over one-third of their budget to help pay for the concert.
Though the number of people who attended was similar to a typical football Saturday, traffic problems did not occur on the same scale. Sunday morning, there were reports of ankle-deep trash in places on Washington Street near the stage, but total trash collected by the city was only 18.2 tons; in 2009, after a night game versus the South Carolina Gamecocks, UGA removed 70 tons of trash from North Campus.
The band filmed the show, and released it on DVD with the title Panic in the Streets. It is currently sold out on their website.
Learn More:
- Athens Observer, April- June 1998 on Microfilm in the Heritage collection.
- Flagpole, 1998 in the Heritage collection.
- Athens Banner-Herald, April 1, 1998 - April 15, 1998 on Microfilm in the Heritage collection.
- Athens Banner-Herald, April 16, 1998 - April 30, 1998 on Microfilm in the Heritage collection.
- Concert and Chaos: A Documentary of the Athens Music Scene by J. M. Davidson in the Heritage and general collections.
- First United Methodist Church, Athens, Georgia: Some History and Recollections by J. P. Bondurant in the Heritage collection.
- Athens-Clarke County, Georgia Comprehensive Annual Financial Report for 1998 in the Heritage collection.
- Downtown Athens website.
- Widespread Panic website.


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Serena Williams Throws Adorable '50s-Themed Baby Shower: Ciara & More Stars Attend
Serena Williams knows how to throw a bash! The tennis pro hosted a star-studded, '50s-themed baby shower on Aug. 5, and the photos are epic! Check out the throwback outfits on Ciara, La La Anthony and more stars in attendance!
Serena Williams, 35, and her celeb BFFs traveled back in time to celebrate her bundle of joy to be over the weekend! The tennis pro threw a '50s-themed baby shower on Saturday, respectively named "Baby O Diner"! "When you and your crew go so far back to the 50's. Even then they had your back," Serena captioned a group photo from the shower, with the hashtag, "Shake rattle and roll 2017". Check out all of the photos from Serena's baby shower in our above gallery!
La La Anthony, 38, Ciara, 31, Kelly Rowland, 36, and Eva Longoria, 42, all posed for photos in front of a vintage car, while Serena cradled her baby bump. The athlete and her famous friends all dressed for the party theme, in sock hop-attire; long, flowing skirts, sneakers with ruffled socks, and cute headbands. And, while Serena's sister, Venus, 37, wasn't in the fun snaps, we're sure she was there celebrating her future niece or nephew.
Guests at Serena's baby shower were greeted by a chalkboard, juke box sign that read, "Welcome to Alexis & Serena's 1950's Baby Shower… Shake, Rattle & ROLL"! It appeared as though the shower took place inside of a '50s-themed diner, with old school beverages and tasty treats. Serena and her growing baby bump were the life of the party, and she was glowing. Serena rocked a bright yellow, poodle skirt with black and white polka dot ruffles, a black top that showed off her bump, sock hop sneakers and white pearls. She perfected the theme with her hair in an old-fashioned bun with a red handkerchief tied to it.
Serena and her Reddit co-founder fiancé, Alex Ohanian, 34, are expecting their first child together in the fall. The tennis pro has been proudly flaunting her baby bump in tight dresses and other chic ensembles. And, she's even admitted that her first pregnancy has been nothing short of amazing. In fact, the athlete has even been keeping up with her workouts!
Serena announced that she and Alex were expecting their first child back in April 2017. She showed off her then 20-week bump on Snapchat and the internet nearly broke. Her pregnancy announcement came just four months after she and Alex got engaged in Dec. 2016. And, as for those secret marriage rumors that have been swirling around? — Serena has confirmed that she and Alex have not said "I do" just yet. However, there was a bridal shower, which HollywoodLife.com previously reported.
HollywoodLifers, what did you think of Serena's 50's-themed bash?


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This certain down is classed as a premium filling as the clusters are much bigger as compared to other kinds of goose down so are able to trap more air inside. This heightened level of performance results in less down being required to fill the duvet in order to achieve the exact same warmth; this in turn makes them a much lighter option.
There comes a time when your slightly baby lady or boy reaches the point of self-reliance. Children grow up. I suggest, you were as soon as a slightly lady or boy as well. The first taste of self-reliance normally shows up after senior high school when everyone moves on to their colleges. Right here, they get to reside in dormitory without consistent or day-to-day parental monitoring. Although, this is their first taste of self-reliance, it is still not considered to be a full blown self-reliance because you are still there to support them. When they vacate your home and into their university dorms, they need to build their bedroom area once more.
Conveniently Effective Ways To Transform Your Sheets
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What Everyone Ought To Know About Rubber Sheets Suppliers
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The 3 Most Beneficial Things About Sheets
Offer the bedroom a face-lift for spring and summertime. Change those heavy comforters with bedspreads. This is a simple sewing job for beginners. Bedspreads are available in several basic designs. These include ordinary flat spreads as well as ones with gathers or pleats. All these kinds are fairly easy to stitch.
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The Unforgivable Sins Of Sheets
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Bedspreads, as opposed to comforters, are rather greater. A bedspread is implied to cover the whole bed's box spring region. This likewise represents that a bedspread will likely be a lot even more like a gown equipped to your complete bed, although the comforter is just a hat placed on prime of it. Equally bedspreads and comforters are available in various bed measurements; twin, complete bed, queen and king dimensions. Maintain in brain which the dimensions vary will vary based on each training. The sizes will vary as per accessibility, likewise.
Effective Ways To Make The Most Out Of Sheets
The measurement of heat per system quilt is called a Tog. The score is performed in a laboratory and makes use of a quilt on a flat surface. It is crucial to keep in mind exactly how the quilt drapes around you and in this case you will be able to mark whether you are on a flat ground surface.
If you are not satisfied sleeping in a bed that is practically your size then you must go with the one that is of queen size. The size of bed has to definitely accommodate all the twisting and turning of your body while you are asleep. Nevertheless, if you do have a queen sized bed, then you must also consider consisting of a queen size bed sheet to match the bed. To make things even better, you must have a few bedding sets so you can change your it you desire.
The Best Thing About Brand New Rubber Sheets Suppliers – Awesome Advice
It can be hard to get delighted about picking a new duvet when one has so much to think about … tog ratings, fill power, the benefits and drawbacks of goose down, feathers, silk, cotton or wool; then there's the different hypoallergenic fillings such as 'hollowfibre' and 'microfibre'. Are rubber sheets suppliers manufacturers attempting to puzzle us?
Outrageous Self Obsessed Super Stars Guide To Sheets
Duvets cover come in many different styles like solid colors, prints, or reversible choices. Likewise, bed sheets linen come in many choices too that you could prefer. It is important to have a concept of what duvets cover you are trying to find.
Duvets cover choices consist of solid colors, prints, or reversible choices. Designer bed linen provides a plethora of choices that you may want to choose from. Duvets cover are readily available as designer bed linen or as normal brands that are readily available in the majority of retailers today.
It's Only About Sheets Of Course!
When you are trying to find lasting value, the highest quality goose down comforters are derived from the Hungarian Goose. The goose feathers are hand plucked and then go with an extreme assessment to make sure that have been wash extensively to eliminate dust and for quality. Each and every specific feather goes with the very same scrutiny. For those of you who might be cringing with the idea of hand plucking feathers, let us put your mind at ease. No geese are eliminated in order to make the goose down comforters. Furthermore, the act of hand plucking the feathers is the most humane technique when compared to some other approaches.


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Ads Not Enough, Snapchat Downgraded 25%
With video considered the No. 1 lead-converting content marketing option by a Salesforce executive, it's interesting to see Fidelity downgrade Snapchat by 25 percent. Business Insider reports that while the service boasts a highly sought-after audience, Millennials, it has yet to satisfactorily monetize the business.
"Since ramping up its advertising efforts," Jillian D'Onfro writes on Tuesday, "the company is reportedly on track to generate $100 million in revenue on an annualized basis, after generating $3 million revenue on $128 million in losses in 2014. But some advertisers feel that Snapchat doesn't offer them enough targeting options or analytics, according to [the Financial Times]. The company makes money by charging brands to sponsor videos or photos in its Live Stories section, or create their own custom photo filters called 'Lenses.' "
On Tuesday, Target Marketing suggested how marketers could create content targeting Snapchat's 100 million daily users who view 6 billion videos:
One-Size-Fits-All Video Is Dead. YouTube should remain the home for long-form content, shorter videos need to be housed on Facebook and Instagram (she suggests 15 seconds), and Snapchat can host "ephemeral content."
What will marketers do about this?
Please respond in the comments section below.


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Sharon Creech
Joanna Cotler, 2005 (2005)
Hardcover, CD
Read an Excerpt
Reviewed by Hilary Williamson
id you ever dream of starring in heroic real-life episodes? Then you'll empathize with Leonardo, a dreamer called
by his family and
fog boy
by some teachers (though his drama teacher did say '
it was not a bad thing to be a dreamer.
') Leo
scenarios in his head constantly (and shares them with readers), though reality always intrudes.
eo is the introspective middle child in a lively Italian family. He feels, '
I was always in the middle or on the edge. Watching.
' One day he finds a journal his father Giorgio wrote as a tap-dancing thirteen-year-old. Papa, who had a heart attack a few years ago, does not seem as happy now as he did then and Leo wonders about it. In the journal, Papa mentions his youngest sister Rosaria, but Leo doesn't have an aunt Rosaria. When he asks about her at a family dinner, everyone is upset with him. Leo tries out for the school play, '
Rumpopo's Porch
' (a script is included in the back of the book), and wins the small part of '
an old crone
'. He's not thrilled but fortunately has the support of his best friend Ruby (who plays the donkey). Ruby often '
will rattle his brains
' with insightful comments.
haron Creech pulls all this together, with amazing empathy, into a heartwarming family drama that explores how people change over time, how family sorrows benefit from airing, and the incredible power (and occasional pain) of a youthful imagination.
Note: Opinions expressed in reviews and articles on this site are those of the author(s) and not necessarily those of BookLoons.
Find more Teens books on our
or in our book


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Search results
Stalk Rots Showing Up in Some Corn Fields
"squeeze test" to assess potential lodging. The "push" test is another way to predict ... slowdown the harvest operation. In addition, lodging may lead to ear rots and grain contamination with ...
Columbus Metropolitan Club Presents: Food Distribution: Reliable Yet Fragile
Agricultural, Environmental and Development Economics at Ohio State University; Jack Irvin, Vice President, ...
First Widespread Freeze Arrives; Wetter Pattern Sets In
fact, many locations dropped below 30°F (Table 1), with unofficial observations as cold as 26°F! How ...
Advanced Sales Techniques and Practice
Agricultural, Environmental, and Dev Economics ...
Extended Drydown in Corn
weather progression compared to that of 2018 at the Western Agricultural Research Station, specifically ... Western Agricultural Research Station in 2020 only 8 days in July registered precipitation greater than ...
Does Quarantine Stockpiling Lead to Future Food Waste?
& Applied Economics Association (AAEA) is the leading professional association for agricultural and ... option for preserving food, but may so promote stockpiling that could lead to waste in the future. AAEA ... contact Allison Ware in the AAEA Business Office. ABOUT AAEA: Established in 1910, the Agricultural ...
Meet Shay Pond: Looking to create beneficial change for communities
For Shay Pond, a fourth-year majoring in agricultural systems management (ASM) with minors in ... was through Ohio FFA. During a career development event featuring the agricultural education and ASM ... Food, Agricultural and Environmental Sciences (CFAES). He is currently a co-chair of the team for the ...
Darren Drewry receives ORAU Powe Award
Dr. Darren Drewry, Assistant Professor in the Department of Food, Agricultural and Biological ...
Precautions for Feeding Frosted and Drought-Stressed Forages
stressed forage, send in a forage sample to be tested for nitrates. Most labs now offer nitrate tests, so ... it is likely that you can get a forage nitrate test by your favorite lab. Several labs are listed at ... the end of this article that do nitrate testing. This list is for your convenience and no labs are ...
Gibberella Ear Rots Showing up in Corn: How to Tell It Apart from Other Ear Rots
they produce, and the specific conditions under which they develop. GER leads to grain contamination ... rains during the weeks leading up to harvest. The Gibberella ear rot fungus may also infect via wounds ... made by birds or insects, which leads to the mold developing wherever the damage occurs. When severe, ...


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Jen Leary
- Chief Strategy Officer
- CLA Charlotte
University of Delaware - BS in Accounting and Management Information Systems
Jennifer (Jen) Leary supports CLA's firmwide strategic efforts to fulfil the CLA Promise and our Purpose - to Create Opportunities for our Clients, our People and our Communities as the Chief Strategy Officer.
In addition to supporting various advisory councils within the firm, Jen is a member of the CLA Board of Directors, the CLA Wealth Advisory Board of Directors, the Leadership Advisory Team (LAT), the Executive Team (ET) and Nexia International Board of Directors.
Jen is an executive sponsor of our Diversity, Equity and Inclusion (DEI) team and our newly launched Community Engagement Team (CET).
She has been serving clients for over 20 years in the United States and Europe. Her background includes assurance, consulting, mergers & acquisitions and Global Concierge Services. She has previously served the firm in various roles such as Client Service Leader and Managing Partner of the Carolinas.
Upcoming speaking engagementsView More
Resources and event materialsView More
In the community
World Bank - Doing Business in the United States contributor
North Carolina Association of CPAs
American Institute of CPAs
Nexia International - Global Network Board Member & Strategy Initiative Co-lead;
Charlotte Business Journal's Women in Business Winner - 2016;
Top 40 Under 40 - 2015; M&A Top 40 under 40 - 2014


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Rented USD$ 585 Per Month - Apartment
Nice apartment for rent in San Juan del Obispo, only 8 minutes away from Antigua Guatemala (by car). Located in a beautiful residential complex with clubhouse, swimming pool, private parking, bus service to take you to the town of La Antigua just on weekends. This property has 2 bedrooms with closet, kitchen, living room, dining room, furnished. It can be rented for a minimum of 6 months. Included: Maintenance Fee and water.
Call us for more information. 5505-0125 / 7937-8600 or [email protected]


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Tool Kit Mould
Product Description
Owing to a skilled team of professionals, we are offering Tool Kit Mould that is widely used to carry engineering tools. This tool kit is designed and developed using quality tested raw material. Offered Tool Kit Mould is recognized for its compact design, precise dimensions, perfect finish, rigid construction, high load bearing capacity and cost-efficiency thereby widely demanded all across the market. It is available with us in different shapes and designs and can also be customized as per the specifications laid down by the clients.
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Contact Us
Plot No. A/127, Road No. 22, Wagle Industrial Estate, Thane, Maharashtra, 400604, India
Phone :+918037400157


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The White House's newly proposed BRAIN Initiative promises funding for much-needed research, but how will it help advance the treatment of dementia and rising dementia care costs?
Both the costs and the number of people with dementia are projected to more than double by 2040, according to a rigorous new study led by the RAND Corporation and financed by the federal government. Though the latest estimates are more conservative than previous data released by the Alzheimer's Association, they're still alarming. A New York Times article quoted Dr. Richard J. Hodes, director of the National Institute on Aging: "I don't know of any other disease predicting such a huge increase," he said, noting that an aging baby boomer population would further exacerbate the issue.
The long-term costs of dementia—both economic and emotional—are a clear sign that we as a society need to step up our efforts at dementia research and treatment. And the federal government has responded, with legislation like last year's National Alzheimer's Project Act and the newly-announced BRAIN Initiative. National-level efforts like these may enable more researchers to attack the looming problem of dementia care and its ballooning costs.
Last May saw the creation of a national plan to address the treatment and prevention of Alzheimer's: the National Alzheimer's Project Act, which shows that dementia care is now a real priority in the national health conversation. And, just last week, President Obama announced a new proposal called the BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative, described by the White House as "a bold new research effort to revolutionize our understanding of the human mind" (NPR). The hope is that his initiative will trigger even more interest in innovations such as early detection methods, and provide some much-needed funding for ongoing efforts to map the human brain.
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Indeed, we have been making some progress in the form of clinical trials for new pharmaceuticals, and we've improved early detection of cognitive impairment and biomarkers for Alzheimer's, according to a recent segment on PBS Newshour. With a starting budget of $100 million for the first year, scientists hope that the BRAIN Initiative will bring further attention to the issue, and spur the formation of a concrete plan for research into the human mind.
If we can add to our detail-level knowledge of how the brain functions, say proponents of the BRAIN Initiative, we will gain further insight into diseases like Alzheimer's and epilepsy—and researchers will be able to spearhead a whole new range of technological developments to help with detection and treatment. However, many experts also stress that there's a lot we don't yet know about the BRAIN Initiative. It's a good start, but a lot of brain specialists are skeptical, wondering how exactly it's going to change the current track in neurological research. After all, it's been decades since scientists have been able to really start studying the brain in detail, and many breakthroughs have already emerged, notes an NPR report. Perhaps, some say, the benefit of this latest proposal will be more in terms of PR for brain research and Obama's science agenda.
David Hovda, who runs the brain injury research center at UCLA, says "I think we're promising too much. I don't think it's going to be the big breakthrough that people think it will be." Similarly, other experts worry that $100 million won't be enough to address the plan the president has outlined, and they fear not enough money will be allotted in the future for ongoing research efforts. Nevertheless, the potential for Obama's proposal has been enough to get lots of people excited, hoping that more ambitious goals can be set and more substantive research accomplished.
On NPR's Science Friday last week, NIH Director Francis Collins acknowledged that the BRAIN Initiative is just one part of the effort to map the human brain and jump-start new avenues of research. "This $100 million is, after all, about one percent—the NIH part of it—of what we're already spending on neuroscience," he said.
So what else are scientists around the world doing to advance the brain science of dementia? The EU has a similar aim to Obama's BRAIN Initiative; last year they announced the Human Brain Project, a detailed ten-year plan that proposes a collaborate effort to use new technologies in brain research and mapping. On the U.S. side of the pond, innovative competitions like the SXSW Accelerator program help showcase emerging technologies like this year's winning Neurotrack, a computer-based test of visual cognition that claims to diagnose Alzheimer's disease years before symptoms appear (The Raw Story). If the BRAIN Initiative passes—regardless of whether the motivation is political or altruistic—increasing the visibility of brain research may help focus much-needed attention and funding on future efforts to address dementia.
What's your opinion on the BRAIN Initiative? Do you think it will have a real effect on our understanding of the human mind, or is it just PR? Let us know in the comments below.
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|You are here: Home >> The Bible & Our Perspective >> Understanding and Studying the Bible
|PDF of Article
It is our premise that a person doesn't have to be a
theological scholar to understand the Word of God. Scripture was
written for the "average" person. It was written for the
"nobodies" of the world, for the outcasts and homeless
people, for those trapped in the inner city ghetto, for children, for
poor people, for High School dropouts, for natives somewhere out in
the jungle, who will never know the world beyond their grass hut
village. The wise, the scholar, the influential person - these are
also welcome. But they tend to find it more difficult to humble
themselves and to become like little children - a necessary
requirement for entering God's kingdom (Matthew 18:3; 1 Corinthians
1:26-30, etc.).
A few clarifications need to be made to the above
statements. First, accepting the Word "as is" does not
ignore the existence of figures of speech, idioms, metaphors and
similes, the difference between prose and poetry, etc. Accepting all
these is a part of accepting the Word "as is."
Again, this view is not new!
Dennis Hinks © 2001


text:
Reprinted from RMC eVeritas 3 Feb 19
Deane was diagnosed with ALS on 24 December 2018. A 29-year-old Combat Engineer veteran of Afghanistan, Deane has served nearly 12 years in the Canadian Armed Forces and continues to do so. It comes as a huge shock that somebody so young and healthy could be diagnosed with this illness. Deane is exceptionally young to have been diagnosed with ALS, a disease which typically presents itself in someone's late '50s or early '60s.
Since the diagnosis, Deane and his family have sought advice from the Chief Neurologist of the Massachusetts General Hospital, which is recognized as a centre of excellence within North America; following this guidance, Deane has decided to pursue the latest developments in medical technology to combat the disease progression. Unfortunately, due to the experimental nature of the treatment, funding through the Canadian Health Care system is unavailable. The donations from this campaign would be used to assist Deane in paying for the expensive treatments. Clinical research that justifies this pursuit may be found here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175096/
Without this treatment, the average life expectancy of those diagnosed with ALS is 2-5 years.
See the GoFundMe page at:


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Confusion prevailed over the continuation of retired Madhya Pradesh High Court judge S K Pandey as the head of the one-man panel probing the October 30 jailbreak by eight alleged SIMI activists and their subsequent "encounter" by police, with a top officer today saying Pandey has resigned over the lack of "infrastructure".
According to the officer, Pandey quit over the "delay in providing a car by the government for carrying out official work". However, he also added the retired judge has agreed to continue after government apologised to him.
"Yes, he (Pandey) has resigned citing that the government has not provided him a car for carrying out official work," the officer close to Chief Minister Shivraj Singh Chouhan told PTI.
He said Pandey's resignation has not been accepted.
When contacted over phone to know whether he has withdrawn his resignation, Pandey merely said, "Thank you very much" and hang up.
Thereafter, he couldn't be contacted even after repeated calls were made.
According to sources, Pandey resigned yesterday, following which senior officials went into a huddle and scrambled to placate him.
The former HC judge was also probing the murder of Bhopal Central Jail warden Ramashanker Yadav allegedly by the SIMI activists before their escape on intervening night of October 30 and 31 last year.
According to Parvez Alam, the counsel for the deceased SIMI men, the Pandey commission has held two hearings so far and the next hearing is scheduled for March 1.
In a daring jailbreak, the eight SIMI under-trials escaped from the high-security Central Jail on the intervening night of October 30-31. They were gunned down in an alleged encounter by police on the outskirts of city on October 31 morning.
The encounter had mired in controversy with opposition Congress and other parties raising doubts over its genuineness after surfacing of a video clip and audio tapes that questioned the police version.
In a notification issued last November, the government asked the Pandey panel to probe the "circumstances in which the SIMI members escaped from the prison and the officials responsible for it".
"How and under what circumstances the encounter took place at Manikheda village under Gunga Police Station limits on the outskirts of Bhopal in which all eight prisoners were killed…Whether the action taken by the police is justified under prevailing circumstances," the notification stated.
Before setting up the Pandey panel, the government had announced a probe by an SIT comprising CID officers into the encounter and a separate investigation by former DGP Nandan Dubey into the jailbreak. However, it agreed for the judicial probe following demands made by the Congress and other parties.
(With inputs from PTI)


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Boneless chicken breast sauteed and topped with jumbo lump crabmeat, mushrooms, and white asparagus! Perfect for that special occasion, Chicken Oscar!
Chicken Oscar is an American classic. Why not serve it for your next date night dinner.
The truth is I really enjoy shopping and not just for food, its the time spent browsing that seems to soothe me. It's me time and I do enjoy it. On this shopping trip I found some white asparagus, Tuscan kale and the prize, Virginia crabmeat, which is almost the same as Maryland.
A quick note about crabmeat, if you do buy pasteurized and this time of year that's pretty much all your going to find, just be careful of where it comes from. Check the source, and quite frankly I won't buy and crabmeat that's from any other country, first of all, it's not the same crab and just doesn't taste as good, and you have no idea how badly polluted the waters they came from were. I know I've mentioned the same thing about shrimp, you need to be careful of the source of origin.
I knew right away what I wanted to make, in the old days we did Veal Oscar, and with veal out of fashion, I decided on Chicken Oscar.
The Tuscan Kale was fairly tasty, definitely a stronger flavor that we were used to, but not at all bitter. The white asparagus didn't fare so well, they really lacked any flavor and even with peeling them and cutting them down fairly short they were very tough and stringy….next time we stick with green asparagus! These were from Peru which could have been the problem, years ago we only got them from European countries and it was also very tender and had much better flavor. I guess that proves a point about the source of products!
I will say that the crabmeat made up for any lack of flavor in the asparagus it was really delicious, with a lot of great crab flavor. In the old days I would have made a hollandaise to top off this dish, but since I am making an effort to eat just a little more healthy I decided to do without the hollandaise and use the calories all the butter and eggs would have added in my dessert instead…..but that's a post for another day!
Chicken Oscar
- 20 oz boneless skinless Chicken Breast pounded thin
- 8 oz Jumbo lump crabmeat
- 10 oz mushrooms sliced
- 8 asparagus peeled- white or green
- 1 cup chicken stock
- 1/2 cup flour
- 1/2 cup olive oil
- 4 tbsp butter
- splash of white wine optional
- Salt and pepper to taste
- Trim off about 2 inches off the asparagus and using a peeler, clean off the outer layer of the fibrous skin.
- Cook asparagus in a saute pan with water on simmer until tender, then set aside
- Trim excess fat off of chicken breast and place them inside a gallon size ziplock bag and with the flat side of a meat hammer, pound them thin.
- coat chicken breasts with flour that has been seasoned with salt and pepper and then place into a hot saute pan with olive oil
- Saute on both sides about 3 minutes per side or until you have good color.
- Place cooked chicken breasts with a little stock in a baking dish in 325 degree oven to finish cooking for about 15 minutes, place the asparagus in the same dish to finish cooking.
- in another saute pan saute mushrooms in 2 tablespoons of butter until tender.
- add a splash of wine to de-glaze the pan, or just use the chicken stock.
- Add in chicken stock and get contents of pan hot, then add in crabmeat, stir gently and remove from heat.
- When your ready to put the dish together heat the crabmeat / mushroom combo and as it heats take the remaining two tablespoons of butter and coat them in flour, pushing the flour into the butter, add this to the heating crabmeat mixture and it will help thicken the sauce. (the butter flour mixture is called a Beurre Manie)
- Place the chicken breasts on plates and divide the crabmeat mixture, spooning it with some of the juices over top of the chicken breast.
- add two spears of asparagus and serve with sides of your choice.


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With 171 students, Northport Public Schools has fewer kids in kindergarten through 12th grade than Okemos High School has in its marching band alone.
Mackinaw City has 187 students; Alba, 174; Stanton Township, 138.
All are tiny. All are poor -- as judged by the percentage of students receiving federal free lunch assistance.
And all scored better in 4th grade math than larger, richer school districts across Michigan.
In fact, poor rural districts beat the pants off richer districts in seven out of eight academic categories in Bridge Magazine's Academic State Championships.
BRIDGE DATABASE: See how your district is doing
BRIDGE GALLERY: Images of success
Using a database of school statistics compiled by Public Sector Consultants and the Citizens Research Council, Bridge Magazine is honoring Michigan's Academic State Champions in eight academic categories. Just like in the state's football playoffs, the schools are split into eight divisions, by type of community (city, suburban, rural) and by percent of free lunch.
Additional coverage
Library investment pays off for Lakeshore
Southfield wins graduation 'game'
Three cheers for academic success
Walkerville's success is the stuff of movies
And after all the numbers were crunched, College Readiness (as judged by ACT proficiency) was the only academic category in which a non-rural school (Bloomfield Hills) scored the highest in Michigan. Even in that category, small, rural Houghton-Portage finished second.
Adams Township -- a neighbor to Houghton-Portage on the Keweenaw Peninsula -- with 433 students in kindergarten through 12th grade had the highest percentage of eighth-graders scoring proficient or better on the science section of the Michigan Educational Assessment Program (MEAP) test in fall 2010.
The highest 8th grade math proficiency scores were found in Walkerville, enrollment 319.
Twenty-one school districts tied for the Academic State Championship in 4th grade math, with 100 percent of students scoring proficient or better. Of those 21 districts, all are rural, and 15 are classified as poor and rural schools.
What's going on in the hinterlands?
The rural-school routs could be the result of small sample size. A group of smart kids can vastly improve scores in a small district, but would barely move the needle in a high school of 2,000. Some poor, rural schools scored consistently near the top of academic categories in Bridge's analysis, but others were at the bottom. Larger schools often were packed in the middle.
Most educators who spoke with Bridge about the Academic State Championships agreed that small schools have advantages that money can't buy.
"When you go to these rural schools, they don't have 27 Advanced Placement courses and eight foreign languages" like those that are available to students in Bloomfield Hills School District, said Bloomfield Hills Superintendent Rob Glass. "But they've found a way to be really successful. There's not one right way to do things."
In a district with fewer than two dozen fourth-graders, kids can't hide in the back of a classroom, said Amber Ellis, third-grade teacher in Atlanta Community Schools, enrollment 306. Atlanta, located halfway between Gaylord and Alpena, tied for the overall top score in 4th grade math proficiency, with 100 percent of its students scoring at proficient level or higher.
"In a rural school, every day is a parent-teacher conference," Ellis said "You see the parents in the grocery store and churches. You get children and you recognize how they act because their mother acted the same way when she was in school."
On top in the U.P.
Adams Township School District was the overall champ of 8th grade science, with 96.3 percent of its students scoring at proficient or higher on the fall 2010 MEAP exam. Finishing second was Forest Hills Public Schools, with 96.1 percent; Ashley Community Schools (96 percent) was third.
"We're a small school, so we're like family," said Jennifer Pera, science and math teacher at Adams Township. "We can catch those kids who might fall through the cracks in a bigger school."
Another technique employed at Adams: a lake as a classroom. "We snow-shoe out there, we take water samples out there; we do a frog survey every spring," said Mike Benda, assistant principal at Adams Township's Jeffers High School. "We have cutting-edge equipment for water sampling and soil sampling and anemometers from donations (by an Adams Township resident). "If we need something, we can get it.
"There's community support for the science program," Benda continued. "It's the type of area it is. We're a logging and tourist area. They want their kids to learn about the natural environment."
In the regular classroom, students use electronic clickers to answer questions, letting teachers know immediately whether the minds are understanding the lessons.
"Even the kids who don't participate (in classroom discussion), they can participate with a clicker and we can tell if they know what I'm talking about," Pera said. "The technology, combined with the labs (at the lake) and the fact that we're a small school, maybe that all came together at the right time and space."
Another peninsula, another winner
Northport is a poor school district in a rich area. It overlooks Grand Traverse Bay near the tip of the Leelenau Peninsula and serves a community of farmers, blue-collar families and migrant workers.
"Our families don't have boats down in the harbor," noted Northport Superintendent Jeff Tropf. "If you're expecting parents to educate kids, well, that works in some cases and doesn't work in others.
But that's not an excuse," Tropf added. "We don't accept that. We maximize our time. While we have them, there are our expectations."
And those expectations are high. Northport tied with 20 other rural school districts for the top score in the state in 4th grade math proficiency, with 100 percent of its students scoring at proficient or higher on the MEAP.
Northport also tied for the state's top score in 4th grade reading, and was Bridge Magazine's Division 8 State Champion for College Readiness.
At Northport, 30 percent of high school juniors last fall were proficient on all four categories of the ACT, the highest percentage among poor rural schools. Second was Caseville Public Schools, with 28 percent. The average among all state school districts was 17 percent.
"When you have a community where everyone knows everybody, it helps," Tropf said. "It's a tough economy for everybody. Instead of looking at the challenges, we look at the opportunities. Why can't every child be proficient? You can do well if you captivate kids."
8th Grade Science Champions
The divisional winners for 8th Grade Science are:
Mona Shores, Division 1
Niles, Division 2
Forest Hills, Division 3
Lakeshore (Berrien County), Division 4
West Ottawa, Division 5
Houghton-Portage, Division 6
Ashley, Division 7
Adams Township, Division 8
4th Grade Math Champions
The divisional winners for 4th grade Math are:
Ann Arbor, Division 1
Godwin Heights, Division 2
Forest Hills, Division 3
Edwardsburg, Division 4
Vandercook Lake, Division 5
Pewamo-Westphalia, Division 6
Brimley, Rapid River, Harbor Beach, Chassell Township and Mackinaw City, Division 7
Alba, Atlanta, Deckerville, Litchfield, Caseville, Stanton Township, Northport, Fairview, Ewen-Trout Creek, Pinconning, East Jordan, Carson City-Crystal, Wakefield-Marenisco, Boyne Falls, Ellsworth, Division 8
Selecting the champs
To crown "Academic State Champions," Bridge Magazine used the following techniques:
* For rankings in 8th grade math, science and reading and 4th grade math, reading and writing, Bridge compared the percentage of students scoring at or above proficiency standards on the Michigan Educational Assessment Program (MEAP) from the 2010-11 school year.
* For college readiness rankings, Bridge compared the percentage of juniors earning proficient scores in the four academic categories of the ACT in 2010-11 school year; Students needed to earn proficient scores in English, math, science and reading to be considered college-ready.
* For graduation rankings, Bridge compared the four-year graduation rates (the percent of freshmen who graduate in four years) for 2010, the most recent year available.
Bridge placed school districts in division by community type and socioeconomic status.
Districts were divided into city, suburban and town/rural by designations made by the National Center for Educational Statistics. Schools were further split by percentage of free lunch, a commonly used indicator of poverty level. Schools were divided as follows:
Below 20 percent free lunch, 20 percent-40 percent free lunch and above 40 percent free lunch. Because there were only three city school districts with below 20 percent free lunch, those schools were included in the affluent suburban division.
The divisions are:
Division 1: City school districts with 20 percent-40 percent free lunch.
Division 2: City school districts with over 40 percent free lunch.
Division 3: City and suburban districts with under 20 percent free lunch.
Division 4: Suburban districts with 20 percent-40 percent free lunch.
Division 5: Suburban districts with over 40 percent free lunch.
Division 6: Rural/town districts with under 20 percent free lunch.
Division 7: Rural/town districts with 20 percent-40 percent free lunch.
Division 8: rural/town districts with over 40 percent free lunch.
Editor's note: Detroit Public Schools, because of its size, did not have a true peer group and was left out of the championships. Bridge will hold a separate championship for schools within Detroit at a later date.


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Centralised authorisation procedure
The British medicines agencies in both the human and veterinary fields (MHRA and VMD) have undertaken a number of tasks on behalf of the community. These tasks must now be undertaken by the remaining EU countries.
Together with the EMA and the other medicines agencies in the EU, the Danish Medicines Agency has therefore worked determinedly to create an overview of the tasks to be distributed and the resources available. We are actively involved in this process so that we can take on our share of tasks to ensure that the supply of medicines will be disturbed as little as possible by Brexit.
Together with the other agencies in the European network, we have assessed that there are many strong forces which together can undertake the tasks that the UK will no longer be handling. In this connection, the Danish Medicines Agency is one of the European agencies having the strength to undertake this work in a number of areas. We have therefore actively offered our contribution to handle the tasks to be distributed and have up until the beginning of July 2018 accepted to take over approximately 30 rapporteurships/co-rapporteurships in the human and veterinary fields.
For information about what applies to centrally authorised products, we refer to the guidelines of of the CMDh/v and the EMA.
CMDh Brexit information including Q&A
CMDv Brexit information including Q&A
EMA identifies gaps in industry preparedness for Brexit
Practical Guideline Document (PDF)