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Weekapaug Cottage Sells for $2.625 Million by Lila Delman Real Estate International
Posted by Dom Costa — May 26, 2017
WESTERLY, RHODE ISLAND – Lila Delman Real Estate International continues its surge to lead the state with extraordinary sales in 2017. 9 Winona Avenue in Westerly was sold for $2,625,000 by Lori Joyal, Managing Broker of Lila Delman Real Estate International's Watch Hill office.
This represents the second highest single family home sale in Westerly year-to-date according to data from the Rhode Island Statewide MLS.* 9 Winona Avenue received multiple offers and sold above its list price of $2,500,000.
The classic beach cottage circa 1910 is sited on a 12,120 square-foot lot with ocean views. Measuring 1,496 square feet across two levels, the house has 5 bedrooms and 2 bathrooms.
"The exceedingly low inventory combined with the extraordinary desire for our beautiful Rhode Island coastal properties continues to rise as evidenced by the sale of this quintessential cottage in WEEKAPAUG," commented Lori. "Our charming seaside communities within southern Rhode Island are amongst the highest in demand."
About Lila Delman Real Estate International
Lila Delman founded the company's original office in Narragansett over 50 years ago. Since then, Lila Delman Real Estate International has grown to include 6 strategically located offices, over 100 associates, a marketing department that creatively uses online social media, and an award-winning website. Utilizing international marketing partners such as Christie's International Real Estate, Mayfair International Realty and Luxury Portfolio, the firm is consistently a frontrunner in the luxury market. For more information, please visit LilaDelman.com.
For more information, please contact Catherine Cloney at Lila Delman Real Estate International at 401-662-2570 or firstname.lastname@example.com.
*This representation is based in whole or in part on data supplied by the State-Wide Multiple Listing Service. The MLS does not guarantee and is not in any way responsible for its accuracy. Data maintained by the MLS may not reflect all real estate activity in the market.


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Barbados, Suriname call for more youth involvement in CARICOM
GEORGETOWN, Guyana — Barbados and Suriname have stressed the importance of youth participation in the regional integration movement, as they reassured the Caribbean Community (CARICOM) secretary-general of their commitment to active participation in CARICOM's success.
The sentiments were expressed on Thursday when their new ambassadors to CARICOM, David Comissiong of Barbados and Chantal Elsenhout of Suriname, presented their letters of credence to secretary-general Irwin LaRocque at the Georgetown, Guyana Headquarters of the CARICOM Secretariat.
LaRocque said both countries have played historic roles in CARICOM; Barbados as one of the four original signatories and Suriname as the first non-English speaking member of the Community.
Comissiong in his remarks said that the active engagement of the youth was critical to "advance the CARICOM project."
"The future of the Caribbean will be achieved through the involvement of our young people. Geographical boundaries do not exist in the minds of our young people. They fully recognize the Caribbean space as theirs to exploit, with or without the help of Governments, but beyond that they see the whole world as their horizon," he said.
Within Suriname's responsibility in the CARICOM Quasi-Cabinet for community development, cultural cooperation including youth and sports, Elsenhout said her country considers it important, "to constantly invest in our youth."
"Suriname reiterates its commitment to the work in the social and economic development of this group in the region. We are looking forward to closely working together on projects and programmes to enhance youth participation, sports and cultural people to people contact within our country," she added.
LaRocque acknowledged the role being played by Suriname's President Desi Bouterse.
"These are important elements of Community life to which President Bouterse has demonstrated great commitment and dedicated leadership," he stated.
The secretary-general also praised the impetus that Mia Mottley, prime minister of Barbados, brought to the CARICOM Single Market and Economy (CSME) since her election earlier this year. He said that this energy will continue at the special meeting of the conference of heads of government on the CSME in Trinidad and Tobago on December 3-4, and well beyond.
Comissiong noted that his prime minister is endeavouring to "reenergise the successful implementation of the CSME, with the ultimate goal of the sustainable development of individual member states and the long-term sustainability and success of CARICOM."
Barbados also remains committed, he said, to continue to highlight the need for urgent attention to the effects that natural disasters present to the lives and the living of the people of small island developing states (SIDs).
Mottley holds responsibility for CSME in the CARICOM quasi cabinet and also serves as the chair of the prime ministerial sub-committee on reparations. In respect of reparations, LaRocque noted the role of Comissiong, describing him as one of the pioneers in the region, having campaigned extensively in support of reparations as well as having published a book on the topic.
Underscoring the significance of the ambassadors' accreditation, he said as new members of CARICOM Committee of Ambassadors and as special representative of their head of government, they will play key roles in implementing decisions of the Community organs at the national level.
"A significant part of your mandate is to engage and interact with the citizens of your country to highlight and promote the objectives, work and benefits of the Community. This is an essential contribution to strengthening the CARICOM identity and spirit of community," LaRocque said.
As the Community approaches 2019, the final year of the first community strategic plan, he said that much work is still left to be done, while planning for a second five-year plan is already underway. The CARICOM Committee of Ambassadors' involvement in the preparations for the second plan will be of critical importance, he told the new ambassadors.
"You, therefore, come on board in a dynamic phase of our integration process. I look forward to your participation in the next meeting of the Committee on 6 December," he said.


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Three's a Crowd
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Congress has voted to change Social Security in an effort they say will save the government money. In this week's boralogue, John shows that it will actually lessen the amount seniors receive by limiting their options. This begins the great reneging, where promises collide with reality. Money being poured into social programs will go toward servicing our unmanageable debt. As we count down to Election Day 2016, remember that whoever is in office when the powder keg blows will receive the blame.
Eliminating disease during fertilization that will result in a healthy child sounds good in theory. But are we gene slicing off more than we can handle? Molecular biologist technologist Rebecca Taylor (www.marymeetsdolly.com), examines the emergence of three-parent offspring and the dangerous pace of human genetic testing. This could lead to human-designed babies that are smarter, faster, and stronger, but will they still be human?
We reported over the summer that several government agency databases were hacked and personal information compromised. Joining us this week is Bartlett Cleland (www.ipi.org), Research Fellow with the Institute for Policy Innovation, who discusses the Cyber Security Information Sharing Act and how inter-agency sharing could lead to a majority of American citizens with government profiles.
Who could oppose the Muslim Leadership Initiative plan to allow Muslims to better understand Jews and Israel? Answer: the Boycott, Divest, and Sanctions (BDS) movement. Cinnamon Stillwell (www.campus-watch.org), West Coast Representative of Campus Watch, reveals the source behind BDS's opposition to this program and shows the difficulty students face with political activist teachers.
Remember: Truth is hate speech only to those people who hate the truth.
This week in Section 6, for online subscribers, John takes a closer look at both political correctness and the European migrant crisis.
Follow us on the Steel on Steel Facebook page and remember to join Praying for Persecuted Christians on Facebook for the latest information concerning persecuted Christians around the world.
Want more resources on these topics? Here are some previous programs you might find interesting:
- Not as it Seems
- Predictions for the Year
- Running in the Wrong Direction
- Value Added Constitution
- Smiley Fist
- No News That's Fit to Print
- Historic Illiteracy
- Marxism vs. Freedom
- Land of Prophecy
- Truth, Justice, and the American Way
- Trying to Eclipse the President
- Postmodernism Circling the Drain
- War From Within
- Suicide of the West
- Spontaneous Design
Posted by John Loeffler | 0 Comments
Loss of the Individual
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Another week, another debate; this time the myriad of GOP presidential candidates took to the stage. Meanwhile, behind the scenes, Congress is scrambling to pass laws to repair Social Security and prevent its imminent demise. In this week's boralogue, John compares the reality of what Republican candidates are saying and the unrealistic ideology of Democratic candidates. Bernie Sanders wants to give away free stuff. The question is: who will he steal from to pay for it?
The stuff of science fiction movie scripts is quickly becoming the reality of science today. Investigative journalist and author Annie Jacobsen (www.anniejacobsen.com) joins us to discuss the Defense Advanced Research Projects Agency (DARPA), its brain to computer interface projects, the ethics involved, and the beginning of artificial intelligence.
All religions and nations should work together in harmony for the good of humanity. Sounds great, right? Carl Teichrib (www.forcingchange.org), Chief Editor of Forcing Change, recently attended the World Parliament of Religions, which promotes this religious harmony, and reports on the conference's true agenda: religious dilution, acceptance of all gods, and a move to favor the collective over the individual.
John finishes up by looking at a debate in Canada this past week that highlighted the conflicting nature of political correctness. It's time to speak out against the ridiculous.
As always, join us online for our weekly Section 6 intelligence briefing, featuring analysis by John on important stories highlighting emerging geopolitical trends around the world. This week, John takes a closer look at the persecuted Christian church.
Follow us on the Steel on Steel Facebook page and remember to join Praying for Persecuted Christians on Facebook for the latest information concerning persecuted Christians around the world.
Want more resources on these topics? Here are some previous programs you might find interesting:
- Division of Diversity
- It's All in Your Head, Kids
- Actions Speak Different Than Words
- Suicide of the West
- The Alliance of Civilizations
- Toward a Global Currency
- Hard Questions Obama Dodged about NSA Snooping
- What an Outrage!
- John's Commentary Articles
- Damage Control: What Ken Ham Should Have Said
- American Not Say-ism


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NORTHVALE BOARD OF EDUCATIONPresident
Mrs. Jennifer Venditti
Vice PresidentMrs. Jamie Corday
MemberMrs. Nicole CowleyMrs. Michele MarinuzziMr. John BriguglioCOMMITTEES
Mrs. Cowley
Mrs. VendittiLegislative/Policy
Mrs. Corday
Mrs. MarinuzziFacilitiesMrs. MarinuzziMr. BriguglioFinance
Mrs. Venditti
Mr. BriguglioNew Jersey School Boards AssociationMrs. CowleyBergen County School Boards Association
Mrs. MarinuzziNorthern Valley Joint Boards Association
Mrs. Venditti
Mrs. CordayNegotiationsMrs. CordayMrs. Cowley
Last Modified on July 13, 2020


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This Election Proves White Men Are Still In Power
If you're anything like me, you spent nearly all of election night with your stomach in your throat, anxiously refreshing Twitter and flipping between CNN and MSNBC, hoping for a miracle. At a certain point, you, like me, probably came to the revolting realization that half the population of this country voted for Donald Trump to become president, proving something we objectively knew but desperately hoped wasn't true: white men are still very much in power in our country, and we are far from being an equal nation.
And that's a very, very scary thought.
Donald Trump ran a campaign of hate and fear; he galvanized Americans against one another, and touted his "outsider" status as the change we needed to fight the corruption his voters believed had unfairly forced them to the margins. He built a campaign based on bashing "the Other" — whether that be Latinos, African-Americans, women, Muslim-Americans, LGBTQ+, people with disabilities. The fact that he earned so much of the vote after publicly offending so many groups of Americans makes it very clear who's still in charge in our country.
And it's not the people being bashed on a national stage.
For these five reasons, this election proves that white men are very much in power — and this country is so far from being equal:
1. He Bashed Mexicans And Immigrants... Multiple Times — And Still Won
In his opening remarks to the nation as a presidential candidate, he bashed Mexicans and called them "rapists," "criminals," and drug dealers. Instead of apologizing, he doubled-down on his anti-immigrant and anti-Latino rhetoric and promised to build a wall separating the United States from Mexico.
2. He Threatened A Ban On Muslim-Americans — And Still Won
It should go without saying that threatening to ban an entire group of people based on their religion is a terrible idea. It goes against the founding principles of our Constitution — remember that thing? That document that guarantees freedom of religion? Trump's rhetoric has made it clear he believes that right can be selectively revoked.
3. In A Leaked Video, He Bragged About Groping Women Without Consent — And Still Won
Donald Trump has degraded women countless times. In a leaked video, he admitted to groping and kissing women without consent, though he claimed to have never acted on it. He called Hillary Clinton a "nasty woman." He's demeaned women for their looks and for their weight. He has shown us, at every opportunity, that he does not respect women.
And, as of Oct. 28, 12 women had publicly accused him of sexual assault. He has denied all of the allegations against him.
4. At A Rally, He Mocked A Disabled Reporter — And Still Won
Last November, Donald Trump publicly mocked reporter Serge Kovaleski, who has arthrogryposis, on stage. Would you even want to be friends with someone who behaved like that? So why would you elect them as president?
5. He Is The Least Experienced Candidate In Modern History — And He Still Beat One Of The Most Experienced Candidates In Modern History
Hillary Clinton is one of the most experienced candidates in modern history — and yet she still had to wade through a river of sexism and misogyny to prove herself against the least experienced candidate in modern history. So, who do you think is *really* in charge in America today?


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Pacific Bay Acquires BC Gold Property
VANCOUVER, BRITISH COLUMBIA–(Marketwire – Oct. 21, 2009) – David H. Brett, President and CEO, Pacific Bay Minerals Ltd. (TSX VENTURE:PBM) (the "Company") reports that Company has acquired by staking 3 minerals claims in the Liard Mining Division covering the historic Tri gold and polymetalic showing explored by Cominco, Continental Gold and others in 1989-1990. Of interest to Cominco were quartz vein systems and quartz-carbonate vein breccias grading up to 13.2 grams per tonne gold and 435 grams per ton silver. The Tri property has not been explored since 1990 and the Company believes that further exploration is warranted.
The Company retained consulting geologist Steve Noakes, formerly with the Cominco team that staked and explored the Tri Property, to complete a summary report and develop recommendations for further work. A geological mapping and sampling program is planned for 2010 to verify the historic data and in particular look for evidence of intrusive hosted mineralization underlying the quartz vein and hydrothermal breccia zones.
"The Tri property area was subject of a staking rush in 1988 following the release of extremely high regional geochemical results by the Province of BC," said CEO David Brett. "The high gold and polymetalic anomalies have received only minor exploration work and we are looking forward to taking a closer look during the 2010 exploration season."
About Pacific Bay Minerals Ltd.: Pacific Bay is a mineral exploration company with a diverse portfolio of properties with an emphasis on mineral discovery worldwide. The Company has extensive land holdings in Quebec's Otish Mountains Uranium region, uranium and gold prospects in Argentina, advanced base and precious metal prospect in northern British Columbia, claims in the Red Lake Gold Camp of Ontario, and an exploration office seeking uranium opportunities in Namibia, Africa.
The technical information contained in this news release has been reviewed, edited and approved by Ernie Black, P.Eng., a consultant to the Company and a Qualified Person under policy NI43-101.
Pacific Bay Minerals Ltd.
David H. Brett, MBA, President & CEO
The TSX Venture Exchange has not reviewed and does not accept responsibility for the adequacy or accuracy of this news release.


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Understanding the interaction between actors in the product-service system development
Lílian Salgueiro Azevedo, José Carlos de Toledo, Mario Orestes Aguirre González
The objective of this paper is to understand the interaction flow between actors from a customer company and with external actors, mainly with the provider company, when developing a Product-Service System offering. This understanding is useful for companies, because it allows them to identify and analyse how these interactions are managed and transformed into PSS requirements that can be used for designing and developing a PSS. A review of the mapping methods was done, and the Actor's and System Maps showed to be the most appropriate, since they have a clear PSS perspective. The research method used in this research was the case study and the semi-structured interview was used for data collect. The study was developed through the case study of a telecom company, which buys a PSS offering. The conclusion is that after creating the categories for the information flows, it was possible to analyse the information and to identify, e.g. omitted information and non-optimal distance between actors, which can affect the PSS development.
AURICH, J. C.; FUCHS, C.; WAGENKNECHT, C. Life cycle oriented design of technical Product-Service Systems. Journal of Cleaner Production, v. 14, n. 17, p. 1480-1494, 2006.
BABBIE, E. R. The practice of social research. 13th ed. Belmont: Wadsworth Cengage Learning, 2013.
BEUREN, F. H.; GOMES FERREIRA, M. G.; CAUCHICK MIGUEL, P. A. Product-service systems: A literature review on integrated products and services. Journal of Cleaner Production, v. 47, p. 222-231, 2013.
BRINKMANN, S.; KVALE, S. InterViews: learning the craft of qualitative research interviewing. 3th ed. Los Angeles: Sage Publications, 2015.
BRYMAN, A.; BELL, E. Business research methods. 2nd ed. Oxford: Oxford University Press, 2007.
DONALDSON, K. M.; ISHII, K.; SHEPPARD, S. D. Customer value chain analysis. Research in Engineering Design, v. 16, n. 4, p. 174-183, 2006.
KIMITA, K. et al. Who realizes a PSS?: an organizational framework for PSS development. Procedia CIRP, v. 30, p. 372-377, 2015.
LINDAHL, M.; SAKAO, T.; CARLSSON, E. Actor's and System Maps for integrated product service offerings – practical experience from two companies. Procedia CIRP, v. 16, p. 320-325, 2014.
LINDAHL, M.; SAKAO, T.; ÖHRWALL RÖNNBÄCK, A. Business implications of integrated product and service offerings. In: PROCEEDINGS OF THE CIRP
INDUSTRIAL PRODUCT-SERVICE SYSTEMS (IPS2), 1., 2009, Cranfield. Proceedings... 2009. Cranfield: Cranfield University. p. 165-172.
MANZINI, E.; COLLINA, L.; EVANS, S. Solution oriented partnership: how to design industrialised sustainable solutions. Cranfield: Cranfield University, 2004.
MATZEN, D. A systematic approach to service oriented product development. Denmark: DTU Management Engineering, 2009.
MONT, O. Clarifying the concept of product–service system. Journal of Cleaner Production, v. 10, n. 3, p. 237-245, 2002.
MORITZ, S. Service design - practical access to an evolving field. Germany: International School of Design, University of Applied Sciences Cologne, 2005.
ROSE, C. M.; STEVELS, A. Applying environmental value chain analysis to product take-back systems. In: LIFE CYCLE ENGINEERING CONFERENCE, 7., 2000, Tokyo, Japan. Proceedings... 2000. IEEE, p. 38-45.
SONG, W. et al. An integrative framework for innovation management of product–service system. International Journal of Production Research, v. 53, n. 8, p. 2252- 2268, 2015.
TAN, A. R. Service-oriented product development strategies. Bygning: Danmarks Tekniske Universitet, DTU Management Engineering, 2010.
VASANTHA, G. V. A. et al. A review of product–service systems design methodologies. Journal of Engineering Design, v. 23, n. 9, p. 635-659, 2012.
WEEKS, R.; BENADE, S. Servitization: an integrated strategic and operational systems framework. In: PORTLAND INTERNATIONAL CONFERENCE ON MANAGEMENT OF ENGINEERING AND TECHNOLOGY (PICMET), 2014, Kanazawa, Japan. Proceedings... USA: IEEE, 2014. p. 3272-3280.
ZINE, P. U. et al. A framework for value co-creation through customization and personalization in the context of machine tool PSS. Procedia CIRP, v. 16, p. 32-37, 2014.


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There are more than 100 sarcoma subtypes, each uncommon and diagnostically challenging. Conventional chemotherapy has little benefit for most soft-tissue sarcomas; new treatment strategies are needed. Multiple recent genomic studies have provided detailed insights into sarcoma biology, including more accurate classification by molecular subtype, identification of recurrent mutations in oncogenic pathways, and evidence of epigenetic dysregulation. Advances in immunotherapy (adoptive immune cell transfer, tumor vaccine strategies, and immune checkpoint inhibition) have also provided a better understanding of how immuno-oncology might best be applied to sarcoma treatment, including connections to oncogenic pathways that may support combination strategies with conventional and targeted therapies. In this article, we review the latest sarcoma genomic studies and immuno-oncology developments and discuss how the findings suggest potential strategies to improve diagnosis and treatment across multiple sarcoma subtypes. Clin Cancer Res; 21(21); 4753–9. ©2015 AACR.
Sarcomas are classified into more than 100 different histologic subtypes by the World Health Organization, each rare. Most are diagnostically challenging and lack effective systemic treatments. While conventional cytotoxics do improve survival in Ewing sarcoma, rhabdomyosarcomas, and osteosarcoma, they confer little curative benefit in most soft-tissue sarcomas, as confirmed by a recent analysis of 2,665 cases across 11 clinical trials (1). Much recent effort has gone into targeting expressed proteins in activated oncogenic pathways, but these have had disappointing results in phase II trials (2–4), and few sarcoma studies have progressed to phase III (5). Off-label use is common but has shown little evidence of efficacy (6). In this environment, there is a large unmet clinical need when local control measures are insufficient for cure.
By morphology, karyotype, and expression profile, sarcomas have been broadly categorized into two groups. Molecularly defined sarcomas often carry pathognomonic translocations, whereas pleomorphic sarcomas have highly rearranged karyotypes. Recent sequencing studies have provided more detailed insights into the biology of different subtypes and reveal an intermediate group of sarcomas carrying recurrent events in the context of complex changes (Fig. 1).
Three major genomic studies in Ewing sarcoma (defined by EWSR1 translocations to ETS transcription factors) have confirmed its low mutation burden. Notably, all three studies reported recurrent STAG2 inactivation in about 20% of cases (7–9). STAG2 encodes a subunit of the cohesin complex that is also involved in imprinting, chromatin insulation, and regulation of enhancer elements (10). Rhabdomyosarcomas were also reported to harbor a low mutation burden, in line with most pediatric cancers. In general, few mutations are observed in synovial sarcoma, but metastatic and highly proliferative cases have acquired genomic instability, a finding more frequent in adult cases, which provides a biologic explanation for their worse clinical outcomes relative to pediatric patients (11).
Osteosarcoma is notable among pediatric cancers for having a high mutational burden, with median nonsynonymous mutations per genome in the range of 22 to 37 (12, 13). SNP analysis reveals more severe LOH in osteosarcoma than in myxoid liposarcoma or synovial sarcoma (14). In addition, osteosarcoma has one of the highest rates of structural variation of any pediatric cancer sequenced to date (12, 15), with 50% to 85% of tumors exhibiting the hypermutation phenomenon termed kataegis (12, 13). Similar genomic complexity is present in adult sarcomas such as undifferentiated pleomorphic sarcoma and leiomyosarcoma (16).
In contrast, oncogenesis for translocation-associated sarcomas appears to be mediated less by genomic changes and more by altered epigenetic regulation of the transcriptome. A major ChIP-Seq study in Ewing sarcoma reported dual roles for EWS-FLI1 as a transcriptional activator and repressor through distinct chromatin remodeling mechanisms (17). Similar epigenetic regulatory functions have been identified in other translocation-associated sarcomas, suggesting therapeutic options (18).
These and other recent genomic studies provide new and detailed insights into sarcoma biology, with implications for strategies to improve sarcoma diagnosis and treatment.
On the Horizon
A paradigm shift from morphologic to molecular diagnosis
Sarcoma subtypes have traditionally been classified by histology, but this has proven insufficient, for example, in rhabdomyosarcoma. Alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) are the two main subtypes, with ARMS usually associated with translocations fusing FOXO1 to PAX3 or PAX7 (19). Cases with ARMS histology lacking PAX–FOXO1 fusions exhibit clinical behavior and karyotypic changes similar to ERMS (20) and do not require the more aggressive chemotherapy regimen typically prescribed for ARMS. Recent genomic studies now confirm the PAX fusion–positive/negative distinction in terms of single-nucleotide variation, copy number alterations, and transcriptome changes (21, 22). Fusion status is a more useful diagnostic categorization than histology, especially considering the significantly worse prognosis of PAX3 compared with PAX7 fusion cases (23, 24).
Another major recent finding is recurring MYOD1 Leu122Arg mutations in spindle and sclerosing variants of RMS as well as in a subset of clinically aggressive ERMS, albeit with spindle cell morphology (25–27). These findings all provide convincing evidence that molecular classification more accurately captures the true biology and clinical course of rhabdomyosarcoma to guide therapeutic decisions.
Classifying "undifferentiated round cell sarcomas" that have Ewing-like morphology and presentation but lack EWSR1 translocations has also been problematic. Recent studies have identified that some of these cases carry translocations involving BCOR-CCNB3 (28–30), CIC-DUX4 (31, 32), or CIC-FOXO4 (33, 34). These variants are genetically distinct from Ewing sarcoma and portend different prognoses, for example, with BCOR-CCNB3 tumors (28, 29) showing good chemosensitivity, which must now be considered as distinct entities for treatment selection.
The identification of these and many other translocations in sarcomas highlights the need for one generic diagnostic test that can capture all clinically relevant fusions with high sensitivity and specificity, something not possible with standard clinical FISH and RT-PCR techniques. Strategies under development for sarcoma diagnosis include FFPE-compatible high-throughput screens using NanoString's nCounter technology or anchored multiplex PCR for targeted sequencing, methods recently brought into use for lung cancer (35, 36).
Accurate diagnosis is the cornerstone of therapy. Lumping "soft-tissue sarcomas" together as a group for logistical reasons makes neither biologic nor clinical sense and has held back the field. Where few effective therapies exist, clinical trials have the greatest chance of success when applied to well-defined patient groups, which for many sarcomas can only be achieved using molecular diagnostics.
Epigenetic therapy
Evidence implicating alterations in chromatin remodeling in, for example, synovial sarcoma (18, 37), Ewing sarcoma (17), and fusion-positive ARMS (38) suggests that many translocation-associated sarcomas might be targetable with new epigenetic agents. Indeed, these strategies may also apply to other sarcomas, as recent genomic screens of malignant peripheral nerve sheath tumors (MPNST) identified inactivating mutations in two core members of the polycomb-repressive complex 2 (PRC2), most commonly SUZ12 (39, 40). PRC2 effects could be targeted in different ways using EZH2 or bromodomain inhibitors, to reactivate or block transcription. It is worth noting that PRC2 dysregulation activates developmentally suppressed pathways and may explain the overlap of heterogeneous mesenchymal differentiation patterns observed in MPNST and synovial sarcoma. Besides PRC2 dysregulation, recurrent BCOR mutations were found in some fusion-negative rhabdomyosarcoma (21). BCOR is a chromatin modifier that interacts with class I and II histone deacetylases (HDAC) as a transcriptional corepressor.
HDAC inhibitors represent the first generation of approved epigenetic therapy agents, although their use as monotherapy in advanced sarcomas has had disappointing results beyond some prolongation of stable disease (41, 42). Like other drugs tested in advanced tumors, HDAC inhibitors may be more effective in combination with other agents and/or when tested against time-to-event rather than objective response endpoints. Beyond the HDAC inhibitors, phase I and II trials are ongoing for at least three EZH2 and seven bromodomain inhibitors in a wide range of cancer types (Table 1), with sarcomas eligible for some advanced solid tumor trials.
Advances in immunotherapy
Stimulation of host immunity for the eradication of tumor cells has been a long-sought goal of cancer therapy. Cytotoxic T lymphocytes (CTL) are critical effectors of tumor cell killing in animal models, and intense CTL infiltration correlates with good prognosis in sarcomas (43, 44). To stimulate CTL responses, MHCI-directed peptide vaccines have been pursued extensively, usually targeting self-antigens highly expressed on tumor cells but showing restricted expression in other tissues. These include cancer testes antigens such as NY-ESO-1 and others with known relevance to sarcoma (45, 46). Trials of such vaccines have historically shown disappointing clinical effects (47), likely due in part to insufficiency of vaccine adjuvants but also to the mutability of advanced cancers and to mechanisms of immunoevasion. This strategy may be most relevant to cancers with low mutation rates that consistently express such antigens. In synovial sarcoma, NY-ESO-1 has been targeted by autologous T cells transduced with high-affinity T-cell receptors, with partial responses in 10 of 18 cases and one durable complete response in recently reported phase II results (48). Trials using other NY-ESO-1–specific T cell and dendritic cell vaccines are open in several types of soft-tissue sarcomas (Table 1).
The role of targetable immune checkpoint proteins such as CTLA-4 and PD-1 in sarcomas is not yet well characterized but is a subject of active investigation. Preclinical investigations of other inhibitory receptors expressed on dysfunctional and regulatory T-cell infiltrates have shown great promise. High expression of PD-1 and LAG-3 or TIM-3 is regarded as a "fingerprint" of T-cell exhaustion; genetic and preclinical studies show dramatic synergies with combinatorial loss of signaling (49). While further removed from detailed characterization and therapeutic application, the list of agents targeting inhibitory immune receptors and ligands continues to grow (50). Because these agents modify inhibitory signals in previously activated, antigen-specific T cells, as single agents they may be most effective in highly mutated tumor subtypes with the most neoantigen production, as shown, for example, in animal models of osteosarcoma (51). By way of comparison, 0 of 6 patients with synovial sarcoma responded to ipilimumab (52).
The most critical aspect of these modulations relates to interruption of signals involving the myeloid component of tumor infiltrates (53, 54). In the tumor environment, antigen presentation is inhibited (55), and myeloid differentiation is polarized toward regulatory, proangiogenic, and prometastatic phenotypes (56). Monocytes and tumor-associated macrophages comprise the predominant cell type in the infiltrate of many sarcomas, where their high frequency is commonly correlated with poor prognosis (57, 58).
Rational combinations of immune checkpoint inhibitors with available avenues of immune stimulation may translate to substantially improved outcomes for patients with sarcoma in the near future. In the setting of genetically unstable, refractory lesions, many have proposed mutational loss of epitope-specific antigen presentation as an inherent flaw in the design of approaches targeting a single antigen. However, the mutational landscape of metastases in different subtypes, response-associated reversals in the polarization of myeloid cells, and the effects of combinations with checkpoint inhibitors or with conventional radiation or cytotoxic chemotherapy all remain to be addressed in this context.
The cutting edge: interface between immuno-oncology and precision medicine
The modulation of host immunity by conventional and targeted therapies is becoming a central theme in modern cancer therapy. Immunostimulatory activity of radiation (the "abscopal effect") and a number of cytotoxic chemotherapies is recognized and has been related to the stimulation of immunogenic tumor cell death, associated with release of damage-associated molecular patterns (59). Immune stimulation by cytotoxics has also been attributed to depletion of regulatory T and myeloid cells, as well as to direct stimulation of antigen-presenting cells.
Multitargeted tyrosine kinase inhibitors are among the newer agents being used in sarcoma therapy, many of which have immunomodulating off-target effects at pharmacologic doses (60). Sunitinib and pazopanib have comparable IC50 values toward their target VEGF and PDGF receptors, but sunitinib potently inhibits FLT3, a receptor inducing myeloid and dendritic cell maturation (61), and three main efferocytosis receptors (TYRO3, AXL, and MERTK) with IC50 values in the single-digit nanomolar range. However, when scheduled after vaccination, sunitinib stimulates immunity by depleting suppressive myeloid populations, an effect which is again attributable to FLT3 inhibition (62). No such pronounced effect on myeloid cells has been attributed to pazopanib. These observations are especially relevant in light of the "rebound" of myeloid infiltrates that constitutes a major avenue for resistance to angiogenesis inhibitors (63).
Drugs targeting chromatin modifiers, mentioned above as of particular interest in translocation-associated sarcomas, may also have immune effects. HDAC inhibitors upregulate MHCI antigen presentation of natural killer (NK) ligands on tumor cells but may have repressive effects on other immune subsets (64). Polycomb repression of chromatin, linked to neoplastic processes in Ewing, synovial, and rhabdomyosarcomas is also critical for stable lineage commitments and T-cell tolerance, with loss of function contributing to depletion of regulatory T cells and activation of effector T cells (65, 66). Thus, relations between emerging immunotherapies, epigenetic drugs, tyrosine kinase inhibitors, and cytotoxic agents will be complex, requiring further animal model studies and clinical trials to determine the best combinatorial approaches.
Sarcoma treatment: current and future prospects
The paradigm of success for sarcoma targeted therapy was the 2002 approval of imatinib (and later, sunitinib) for gastrointestinal stromal tumors. The newest FDA-approved agent added to the armamentarium for a sarcoma indication (in 2012) was pazopanib, a multikinase angiogenesis inhibitor indicated for nonadipocytic advanced soft-tissue sarcoma. In angiosarcoma, the finding of recurrent mutations in two angiogenesis genes (PTPRB and PLCG1) highlights a redundancy in angiogenesis driver mutations (67) that may explain the mixed results seen in clinical trials of antiangiogenesis agents in vascular sarcomas. The simpler genomes of translocation-associated sarcomas present fewer targetable mutations, and their driver fusion oncogenes usually encode transcription factors that are not targeted directly with available agents. A potential solution is to assess the dependence of particular sarcomas on more common targetable cancer pathways. In this regard, one recent development is the identification of aberrant Wnt/β-catenin signaling in synovial sarcoma models (68) and rhabdomyosarcoma (69). Combination targeted therapy again may have merit: a phase II trial of sorafenib and everolimus combination therapy achieved 45% 6-month progression-free survival (PFS; ref. 70). Although falling just short of its prespecified primary endpoint (50% 6-month PFS), this result is well-above the widely accepted 20% 6-month PFS benchmark for sarcoma drug activity (71) and represents the first positive study for relapsed osteosarcoma in a quarter century.
Challenges remain in developing targeted therapies for sarcomas. Anecdotal case reports of complete responses in patients and of cures in mouse models have not translated into successful clinical trials (2, 3, 72). The relative rarity of each individual subtype has led to their grouping together in clinical trials, but in this setting, the underlying genetic differences among sarcomas will complicate assessment of any drug's efficacy. With insights gained into sarcoma biology from recent genomic studies, a more appropriate way forward may be the use of basket trials (73), in which treatment is determined by genotype instead of subtype. Rare sarcomas can then be combined with rare variants of more common cancers to make a trial simultaneously logistically feasible and biologically rational.
There are other reasons for the dearth of successful targeted therapies in sarcoma: drugs are targeting secondary instead of driver mutations, genomic instability promotes drug resistance, and de novo resistance via alternative pathways is often present. To address these hurdles, multiagent approaches will be needed that ideally include direct targeting of driver mutations and immune-oncology treatments that can evolve as rapidly as the tumor. In this regard, while many sarcomas will be similar to other types of cancer, at least for some types, the driver mutations are more clear and the genetics less complex.
Disclosure of Potential Conflicts of Interest
T.O. Nielsen reports receiving a commercial research grant from and is a consultant/advisory board member for NanoString Technologies. No potential conflicts of interest were disclosed by the other authors.
Authors' Contributions
Conception and design: J. Lim, T.O. Nielsen
Writing, review, and/or revision of the manuscript: J. Lim, N.M. Poulin, T.O. Nielsen
Study supervision: T.O. Nielsen
Grant Support
T.O. Nielsen was supported by grants from the Canadian Cancer Society Research Institute (Impact Grant; grant number 701582), the Terry Fox Research Institute, and the Liddy Shriver Sarcoma Initiative.
- Received June 9, 2015.
- Revision received July 23, 2015.
- Accepted August 3, 2015.
- ©2015 American Association for Cancer Research.


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There are
some days a lot of days when your toddler is flat out bored to death with his toys. He probably will start to whine, nag at you, and beg for the TV. I've been there! It makes the day frustrating when your toddler can't occupy himself, so you go to play with him but he just isn't interested.
These little-to-no prep activities are a great way to bond with your toddler, tire him out, spark creativity, and allow you to have a little bit of peace without having to switch on the television.
1. Bean scoop and dump
Pour dried beans in a container, give your toddler some cups and ladles, and watch her have a blast! I didn't think my toddler would enjoy this activity until I tried it. She had the time of her life playing in beans!
2. Hide and Seek
Your little one will most likely hide in the same spot or show more than half his body sticking out from behind a pillow, but he will burn off energy and have loads of fun with you.
3. Dry Erase Marker on window or mirror
Set your toddler up in front of a sliding glass door or mirror with a few colored dry erase markers and a dry rag to wipe her work clean when she wants. She'll love such a huge canvas to work with!
4. Flashlight fun
Black out the play room or wait until night to break out the flash lights. Play hide-and-seek, make shadow puppets, or just dance and have a great time!
5. Turn on Workout video
I didn't know my toddler would be interested in workout videos until I turned on a pilates exercise one day and she followed along with me. Now I use it as a great way to distract her and burn off her energy.
6. Blow bubbles
If he can't blow bubbles by himself yet, then a bubble gun or larger bubble wand that he can wave around will save you from getting light-headed blowing all those bubbles!
7. Hopscotch
This classic game combines physical activity with creativity! Make squares with washi-tape on the carpet as an alternative to using sidewalk chalk.
8. Make Moon Sand
Moon sand is so easy to make and lots of fun! Combine 2 cups of flour and 1/4 cup baby oil. Check out Little Learning Club for more details.
9. Clean the House
Hand your toddler a sponge, a spray bottle, and a dry rag, and watch him have the time of his life cleaning the floors! He'll feel really proud for helping you out too.
10. Blow Up some Balloons
Kids go crazy for balloons! If you don't believe me, blow up a few and watch your toddler go wild!
11. Dance Party
Holding a "dance party" is great way to burn off your toddler's energy and your own (if you have any left). We have a dance session every single day in our home.
12. Treasure Hunt
Pour dry rice (or cereal) into a container and hide money, candy, or small objects within. Have your toddler dig around and discover the objects.
13. Paint
Don't just limit your toddler to paper! Purchase wooden boxes and bird houses at the dollar store for your toddler to paint on.
14. Play Dress up with your clothes and accessories
Let your little one dress up in some of your scarves, clothes, and jewelry! My toddler always feels so special when I let her dress up in my stuff.
15. Take Photos around the house
This activity has recently become my toddler's favorite. I give her my phone and she goes around the house taking pictures of absolutely everything. Then we sit down together and look over all the photos she took. She actually is getting quite good at taking them!
16. Play a Board Game
Hungry Hungry Hippos has recently become a HUGE hit in our home. I also recommend ThinkFun Roll and Play.
17. Thread cereal onto pipe cleaners
This is a simple activity that's great for dexterity. If threading cereal is too hard, gather some cardboard tubes (cut from toilet paper rolls) to thread onto cord.
18. Cereal Crunch
When I discovered this idea over at Busy Toddlers, I thought: How brilliant! Pour old cereal and pasta into a large container, give your toddler a plastic hammer, and have him smash away!
19. Stickers
Giving my tot a sheet of stickers to entertain her never fails. She quietly sits at the table peeling stickers off and putting them in her coloring book, on cardboard boxes, and sometimes on her baby brother! Purchase bubble stickers (they are slightly raised) so your toddler can grab them effortlessly.
20. Bake or cook together
Whenever my toddler is bored and cranky, I ask her to help me out in the kitchen. It's a great way to teach about different foods, practice cutting veggies or fruit, and encourages your picky toddler to eat.
21. Shape sort household objects
Susie, over at Busy Toddler, shows a great way to keep your toddler occupied with this simple learning activity. Grab some tape to create a circle, square, and triangle right on the floor, collect household objects in different shapes, then have your toddler try to sort them.
22. Monster Print out activity
I absolutely love this activity. It's simple to print out and a quiet activity for your child to do when you want some peace. Download it here.
23. Bowling with Plastic cups
Set up plastic cups as the "bowling pins", give your toddler a ball, and teach him to bowl!
24. Music Hunt
A fun, easy game I made up with my toddler. Send your toddler into another room for a minute while you hide your phone with soft music playing on it (you can also use this cute portable Bluetooth speaker that we love), then hide your phone and have your toddler try to find where the music is coming from. Sometimes I like to hide a little piece of candy with the phone as a prize.
25. Spaghetti play
Cook up a pack of spaghetti, let it cool and dump it in a large container. Give your toddler tongs, a pasta scoop, and some forks to play in the noodles. Not only is this great sensory play for your little one, it's also a great way to get your toddler to eat!
26. Build a fort
We love to drape blankets over the kitchen table, throw some pillows underneath, snuggle together, and read. Or pretend you're lions in a little den.
27. Cardboard ramp over the stairs
Take a large piece of cardboard cut from a box, place it over the stairs (keep it in place by putting heavy objects on the sides at the top), and roll balls or slide books down the ramp.
28. Water Play
Fill a bunch of containers with water and give your toddler a few sponges and dishes to wash. Fun for outdoors or inside (just make sure to put down towels)!
29. Bubble Whisk
This will be messy so it's best done outside on the grass. Fill a large container with water and dish soap, hand your toddler a whisk and encourage him to stir, stir, stir until bubbles form and get everywhere! Head over to Emma Owl to see this activity in action.
30. Ice Cube Play
Dump a bunch of ice cubes into a container, give your toddler some tongs, and have her try to pick up each cube and place it into another container. Another great ice activity involves freezing coins or rocks in ice, giving your tot a plastic or wooden hammer, and letting her smash the cubes until she frees the object inside.
Thanks for reading! Have other fun activities in mind? Let me know all about them below 🙂


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This topic provides some frequently asked questions about MDM Enrollment Server.
How do devices get certificates through Enrollment Server?
The device generates the certificate request and passes the request to MDM Enrollment Server, which impersonates the device account just long enough to submit the certificate request to the certification authority. Enrollment Server does not have permissions to the device-specific certificates and templates on the certification authority; only the device account has permissions. The private key never leaves the device.
Can I automate the enrollment process for new devices?
You can perform bulk enrollments using MDM Shell. Users
can also provision their own devices through MDM Self Service
Portal. However, MDM Self Service Portal only provisions devices
into a single organizational unit (OU) as designated by the
administrator. To download MDM Self Service Portal, see this
Microsoft Web site:
Can I un-enroll an enrolled device?
MDM has no administrative tools for un-enrolling a device. You should submit a wipe request for the device to remove all of the appropriate objects, such as the objects in Active Directory and SQL Server. Wiping also adds the device to the Blocked Devices list. The enrollment record remains in the database so that MDM can block the device. When re-enrolling a device, you should specify a new device name.
How do I configure MDM to send the enrollment e-mail message?
By default, MDM uses firstname.lastname@example.com send the e-mail message containing the one-time enrollment password. To specify an SMTP server for sending these messages, run the following command in MDM Shell:
|Copy Code
set-EnrollmentConfig -SmtpServer smtp.yourdomain.com
You can modify the other parameters similarly by running the following commands:
|Copy Code
set-EnrollmentConfig -SmtpServer set-EnrollmentConfig -EmailSubject set-EnrollmentConfig -EmailBodyTemplate set-EnrollmentConfig -EmailSender
How do I check to see if a device is enrolled?
On the device, select Settings, select Connections, and then select Domain Enroll. The Device Statusfield indicates if the device is enrolled or not.


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ALASTAIR RICHARDS WINS MISO 11'S MAIN EVENTWednesday, May 2, 2018, 11:02
New Zealand scrabbler Alastair Richards won in a convincing manner the 11th edition of the Malta International Scrabble Open, known as MISO 11, as the Main Event played over three days came to an end on Tuesday evening at the Luzzu Restaurant Conference Hall in Qawra.
This Main Event was played between Sunday and Tuesday over 25 rounds. There were two divisions with 38 players in Division A and 44 players in Division B for a total of 82 players.
Richards was the favourite and he finished in first place with 19 wins, followed by Indian Goutham Jayaraman with 17 and a half wins, while Englishman David Webb placed third with 16 wins.
Maltese champion Theresa Brousson also managed to win 16 games, but placed fourth as Webb had a better spread. Another Maltese player, Cecil Muscat, placed eighth on 15 wins.
In Division B Maltese player Pauline Cilia finished in first place thanks to 17 and a half wins. Australia's Paul Richards and Maltese Josephine Mayo both obtained 17 wins, but Richards won second place thanks to a better spread than Mayo who thus finished third.
Two other Maltese players, Anna Borg and Sammy Mangion, finished eighth and ninth respectively, both with 15 wins.


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Pavilosta Poet Huts
The small port town of Pavilosta is located on the western coast of Latvia, at the mouth of the Saka river in Courland. Known for its long sandy beach and idyllic Baltic Sea waters, the town is a popular tourist destination, and is populated with seafaring locals from tenacious fishermen to some of the world's toughest windsurfers.
The architecture of the town is predominantly low-rise housing, with almost all roads leading to the sea, whose crystal clear waters attract creative people to this small town to rest, rejuvenate, and be inspired.
The Pavilosta Poet Huts architecture competition is tasking participants with delivering designs for residences for visiting poets. The key function of the complex would be to offer free residence to selected poets where they could live and work for a defined period of time.
With competition winners being considered for construction, designs for the Pavilosta Poet Huts should focus on eco-friendly and cost-effective building techniques. As Latvia has a reputation as one of Europe's greenest countries, the structure should have the potential to become a regional example of green building practice.
Download full competition brief for more information!
Competition is open to all. No professional qualification is required. Design proposals can be developed individually or by teams (4 team members maximum). Correspondence with organizers must be conducted in English; All information submitted by participants must be in English.
3 winning proposals and 6 honourable mentions will be selected. Bee Breeders will award a total of US $6,000 in prize money to competition winners as follows:
1st Prize – US $3,000
2nd Prize – US $1,500
3rd Prize – US $500
+ 6 honourable mentions
BB Student Award – US $500
BB Green Award – US $500
More information about the special awards at poethuts.beebreeders.com.
Early Bird Registration: OCTOBER 25 – DECEMBER 4
Advance Registration: DECEMBER 5 – FEBRUARY 12
Last Minute Registration: FEBRUARY 13 – APRIL 16
Closing date for registration: APRIL 16, 2019
Closing date for submission: JUNE 4, 2019 (11:59pm GMT)
Announcement of the winners: JUNE 25, 2019


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Dennis Byrne: So Long Illinois
Dennis Byrne 18 October 2019 No Comment
So long, Illinois. Goodbye, Chicago.
Here, I was born and raised. Schooled and worked. Practically my entire life has unfolded in Chicago and close by.
As a kid, I rode on Chicago street cars and the wooden "L" cars before there was a CTA. Took the old North Shore Line to high school and college. Flew out of Midway Airport when it was the nation's busiest and before there was an O'Hare. Caddied in Northfield and labored over a North Avenue knitting mill's steam table. I've worked for three Chicago daily newspapers. I love Chicago. Chicago is my town.
But I've had enough. Fed up. I'm gone.


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How to save money at Walgreens. Walgreens is super convenient but no one wants to pay full price for that convenience. If you employ a few methods you may be able to save money on many of the items that you purchase there. See update to Walgreens Balance Rewards program below – Higher Redemption Levels Return!
Join the Balance Rewards program
As soon as you join add the everyday points perk to your account and you will get 10 points per $1 on almost everything.
There are also Balance Rewards weekly offers where if you purchase a featured item(s) and use your Balance Rewards card you are rewarded with anywhere from 1,000 to 10,000 points an item or purchase. You can check the Weekly Ad in-store or online for qualifying items. You don't have to carry the card just enter the phone number registered to your account. As always you have to know your prices to be sure that the item is really cheaper after the Balance Rewards.
Balance Rewards program Update 5/5/19
The next time you're in the store or shopping online you can redeem your newly earned Redemption Dollars against any purchase except: dairy; alcohol; tobacco; stamps; phone/prepaid/gift cards; money order/transfers; transportation passes; and other items. You can find all the rules here.
Here I applied my Balance Rewards to a 50 ounce container of Tide that was on sale with tax for $5.10. Net cost a dime!
You can cash in points as you go or save up for a future discount. Be careful sometimes they will deduct the Balance Rewards points at the register without asking you.
Items ordered online and delivered to your home will earn points the same as if purchased in-store. Shipping is free for orders over $35. Items ordered online using the "store pickup" feature will only earn points after the items have been picked up from the store.
You can earn Balance Rewards even if items are on sale and if you are using other discounts as in this online order. The original order was $55.78 which included one item that was $5 off. Then I applied $15 worth of coupons, including $10 from Visa Checkout, or a total discount of 33% plus I earned 2000 bonus points or $2 extra. Cha-ching!
Beware – points expire
Points expire one year after they are earned or if an account has been inactive for 6 months. Sadly the Walgreens website only allows you to view points earned in the last 180 days. If you're stockpiling you'll have to contact them to get the date of the oldest points in your account. They have Live Chat on the website that works.
You may also apply your Balance Rewards points to online orders. The same restrictions for in-store redemption apply.
On this online order I applied a 20% off coupon and then $5 of Balance Rewards for a total savings of 30%.
You can sign up for Balance Rewards online or in-store. You don't have to card carry the card. You can just type in your telephone number at the register every time you make a purchase that is eligible for Balance Rewards.
Join Walgreens Beauty Enthusiast
You'll earn 5,000 Balance Reward points (value $5) for every $50 spent on most beauty purchases. In order to reach the $50 purchase requirement, the qualifying spend total is calculated before taxes and shipping, and after discounts, redemption dollars and store credit have been applied. You don't have to spend $50 is one purchase. It's cumulative. Eligible items include: Cosmetics, nails, skin care, hair care, fragrances, beauty accessories and bath products. Excludes prescriptions, baby hair care, baby skin care and men's grooming products.
Clip coupons from the Weekly Ad (no paper involved)
This is the number one way I save money at Walgreens. Every week they have "loss leader" staple items that I pick up such as sugar, vegetable oil, honey, paper plates, plastic wrap, eggs etc. all at rock bottom prices. I review the Weekly Ad online and then "clip" the coupons directly onto my card so you don't need to print anything or tear out coupons in-store. Then the next time I walk by I run in and pick up the sale items.
There's a limit of one coupon printed per offer. So even if you purchase the same item twice you will only receive one coupon. Check your coupons for exclusions, limitations and expiration date.
Check your Balance Rewards account regularly via the app or online and clip special offers and "perks" to your card
While writing this post I looked in my account and found a "perk" Bonus Offer August 29 – September 6 Get 7,000 points when you spend $20. There are no details so I will assume that it has to be in one purchase.
Use Register Rewards
When you shop with your Balance Rewards card sometimes coupons will print out with your receipt. These are Register Rewards. They are coupons that print when you make a qualifying purchase of an eligible item(s). They can be used like cash on your next purchase. You can check the weekly ad online or in-store to find out which products are eligible for register rewards that week. As always you have to know your prices to be sure that the item is really cheaper after the Register Rewards. Register Rewards are only available in store.
Sign up for their Newsletter
The email newsletter offers discounts not available online or in stores. I've received offers for 20%, 25% and 30% off my whole order. I keep a list of things I will need soon and use these coupons to pick them up at a discount.
Shop Walgreen's store brands
Like grocery store brand products many Walgreen's brand products have the exact same ingredients as the name brand versions but cost much less. Many Walgreen's brand and Nice brand products are also the weekly loss leaders as mentioned above.
Pick up the Monthly Coupon Book or review online
These are usually located in the front of the store by the weekly flyers. You can go through it once a month to see if there are any good deals. Review online. If this link stops working Google "Walgreens monthly savings book".
Link your AARP membership to your Balance Rewards Card
Show your Balance Rewards card to get your AARP discount at participating Walgreen's locations to get exclusive benefits like 50 points for every $1 spent on Walgreens brand health & wellness products, earn 100 points per prescription and more. You can link your card online or by calling (877)-250-5823. It takes about three business days to confirm your AARP account.
Shop on Senior Days
Get offers such as 20% off regular priced merchandise during Seniors Day – the first Tuesday of every month. These are open to anyone 55 and older or anyone with an AARP card. If you're in-store you may have to show ID. If you are shopping online make sure your birthday is in your profile.
Take advantage of the Balance Rewards for healthy choices® :
- Earn points for walking, running and tracking your weight
- Track progress toward your fitness goals
- Sync a device to log activity on-the-go
- Connect with friends in our revamped community forum
One you have a Balance Rewards account you can sign up for Balance Rewards for healthy choices.
How to set up in-store pick up
Recently Paypal sent me a birthday offer – Spend $15 get $5 off when paying with Paypal. The only vendor where I needed something was Walgreens. Shipping is free on orders of $35 or more so I wasn't going to pay for that. Shipping to a store is free with any order total – no minimum required.
- Every item in your cart must say "Ship to Store" for your order to qualify. You'll be able to choose your destination at checkout.
- Click on proceed to check out even if you plan to pay with Visa Checkout, Paypal or Masterpass.
- If everything is eligible for in-store pick up you will have the option to select.
- Select in-store pick pick.
- Pay using your method of choice.
- Open a Balance Rewards account. Make sure you include a phone number when you sign up. Then enter it every time your shop at Walgreens.
- Join Walgreens Beauty Enthusiasts Club.
- Sign up to receive the weekly ad.
- If you are 55 or older make sure your birthday is in your profile. If you're a member of AARP link your AARP card to you Balance Rewards account. Both will enable you to get 20% off online on Seniors Day – the first Tuesday of every month.
- Review the weekly ad when it comes out and clip all the sale items and coupons to your card.
- Pick up or review online the monthly Savings book.
- Make a list of the deals that you can't clip to your card.
- Check your Balance Rewards account for offers to clip to your card..
- Enjoy your savings!


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Have you found anything difficult this week?
This week has been a bit of a disaster! I woke up with a painful shoulder last Sunday morning; my other half likes to use me as a pillow. Unfortunately rather than getting better, it has just gotten worse, resulting in a trip to the physiotherapist on Saturday morning!!
On Tuesday I got my backside to the gym, having not been since the previous Thursday. I ran one mile then did my Zumba class. It took me a lot longer than usual to recover, and I was aching for most of the week. I also haven't wanted to go with my shoulder being so painful, and the advice of the physio is to stay out of the gym for the next week!
This week I've made a conscious effort to reduce my portion sizes, particularly of my evening meals, and clearly this has made a huge impact on my weight, considering I've barely trained! I have been naughty and had some cake at work, the whole Lent thing lasted about 4 days…I have no willpower when I'm feeling stressed out!
Weigh In
I wasn't too sure what to expect when I got on the scales this morning, I've barely trained and I haven't weighed myself during the week. I definitely got a pleasant surprise when I saw that the scales read 8 stone 11, and I will be definitely careful with my food going forward.
The Next Week
The biggest issue for next week, is the fact I've been told to stay out of the gym. I'm not going to go against this as I've been in so much pain. I will again be ensuring I eat smaller portion sizes and I guess it will be interesting to see what the scales say next weekend with a whole week of no training – so watch this space!! I've been given some exercises to strengthen the muscles around my shoulder blades, and I will be making an effort to improve my posture, hence the held back shoulders in the pictures!!
Remember I also have a giveaway running at the moment for 5 lucky readers to win a tube of the £24.99 Adigym, reportedly used by Rihanna, make sure to enter here.


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PhotoFunStudio will not print.
If the printing function is available, and you can access it, the issue is with the printer and not the software.
First, check the driver installation. Go to Device Manager and make sure there are no items with yellow exclamation marks. In case there is something there, right-click it and choose Update Driver.
Secondly, make sure the printer is connected and turned on. Go to Control Panel > Hardware and Devices > Printers. Right click the printer and choose Default/Enabled.


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Web Nexus
Web Nexus: The Significance of Responsive Web Design. Responsive web design refers to the art of designing a website in such a way that it can be adjusted automatically in different screen sizes and devices according to the needs.
Thus, end users can get an optimal experience. The websites that are designed 'device agnostic' are good, because they aren't designed or developed targeting any specific screen resolution. Instead, they are made for all devices with different screen resolutions. Since the content of the websites flows and adapts to different environments with ease, users enjoy what they see on the devices. In this highly competitive era, the need of a responsive web design can't be overlooked. Designing a responsive website could be a challenging task, especially if you're not geared up with the enough knowledge in this field.
What Questions to Ask Before Hiring a Web Designer? If you're someone, who is looking to hire a web designer, you may be feeling a bit overwhelmed.
And why wouldn't you be? There are thousands of web portals that offer similar services. So, how do you make sure you don't end up getting scammed? Web Nexus: How to Find the Right Software Company in California or Anywhere Else? Software development is a booming industry and that's why more and more people are investing in this industry.
Every kind of work can be handled easily no matter how difficult it would be if you have the right software with you. In order to get the right software for your business all you need is the right company. Now the question is, which is the best company? So it is important for you to know that it is the employees that make a particular company great. It means whenever choosing a company for your getting your work done is look for the employees working there.
There are several software companies in California and the number is growing with the passing of each day. Evaluation of RequirementsSoftware ArchitectureImplementationTestingDocumentationTraining and SupportMaintenance. Factors to Choose the Best Web Design Company. Welcome to Web Nexus - A Full Service Digital Agency. Web Development Company California. Here at Web Nexus, we are known for delivering scalable business value to our clients across the globe.
We are a leading IT boutique that can help you maximize your revenue-margin. Equipped with the modest technology, right infrastructure and intellectual property, we assist our clients reach their desired milestones. We are proud to state that our IT solutions are meant to provide you an edge over your competitors. Ranging from software development to quality assurance and testing, name any IT service and consider it done with the best practices only. Brand Management Company. Brand management at Web Nexus begins with a comprehensive knowledge of your brand.
A brand may include your business logo, mascot, or any other feature that represents a unique identity of your business and even offered products or services. Branding - A Necessity For Every Business. You all are familiar with the term "brand" and if not, then you should get some information about it.
There are a number of brands related to a single product and people are attracted to renowned brands as these have a good reputation in the market. There is a stiff competition in the market and to survive this competition, you will need an excellent brand management strategy. Before going further, you need to know what is brand management? It is the process of maintaining, upholding and improving a brand's name.
Earlier mass media channels such as radio and television were the only mediums where you can market your brand. Different Phases Of The Website Development Process. Different Phases Of The Website Development Process Marketing a newly launched product or a business is quite necessary so that the people get to know about it.
In order to make a mark in your concerned field, marketing is quite important. There are different marketing techniques in order to reach out to your target audience. Out of the different techniques, web marketing is most sought-after, which is getting quite popular these days. Why Use a Web Content Management System? Posted by Webnexus in Business on July 19th, 2016 Without a doubt, the internet can be considered the backbone of any business.
It is, in fact, one of the most effective and useful marketing tools that can help take any business to the next level. Due to this reason, almost all businesses have their online presence over the web these days. To have an online presence over the internet, a business, first off, needs to have a dynamic and effective website. The web portal is, in fact, the first thing that people notice.
Having a website and handling all its elements could be a difficult task, unless you use the right tool. With the effective use of a content management system (CMS), businesses can now have well-maintained and professionally looking websites. Role of Brand Management In Making a Business Success. Do you know what is brand management and what is its role?
If not, then you should know that it is the analysis and planning on how a particular brand is perceived in the market. It is the part of the marketing process and instills a certain level of confidence in the minds of the people to make use of a brand's products or services. From marketing point of view, branding plays an important role in making a brand popular among people. Three Steps to Hire the Best Software Company for Your Business. By Web Nexus Mobile App Development San Francisco Browse online portals and you are likely to come across many IT (Information Technology) companies that claim to provide the best software development services.
Since you can have a wide array of options, therefore choosing a software company may seem an easy task. However, it's not a simple task, unless you consider the right factors. Be it a start-up or a well-established company, software development services can be hired by the businesses of all sizes. Like others, if you are also looking for the best software company in California, then you should follow the given below three steps. Conduct a Market Research: You can't afford the risk of picking any company randomly and then bearing the false results. Take References from Existing Clients: Since most of the companies showcase their past work and portfolio, therefore, you can easily find the contact details of their existing clients.
About Web Nexus Mobile App Development San Francisco. Choose a Web Development Company to Design and Develop a Website For Your Business. With the advancement in technology, the way of doing different things also underwent a tremendous change with most of the things happen with a few clicks of mouse. Technology has made possible those things, which previously look impossible.
Previously, you didn't even think of talking face to face with your near and dear ones sitting at a distance from you, which is now possible through a video chat. There is a huge development in every field, especially the web development field with the traditional paper-copy method of storing information replaced with software. You all are familiar with what a website is, but maybe you don't know what it values for a business? Five Tips For an Excellent Website Design. June 10 2016 Written by Web Nexus and from Overblog A good website design has the ability to grab the attention of more number of people and makes a huge difference to a website's look. If you are planning to design a website for your business, then it is important for you to first evaluate what are your requirements which will be helpful in making the right decision. Your website has the ability to multiply your profits if you have done proper research by staying ahead of time.
There are people out there who put a good amount of money without doing any research and end up wasting that money. Below are some tips for an excellent website design: How to Design Your Website Yourself Through CMS. Uncategorized. How to Grow Your Business Through Brand Management. Common Factors to Hire the Best IT Service Provider. "Many big organizations are turning to managed IT service providers with an aim to free up their internal staff, so they can focus on their core projects" - a report says. In this tech era, hiring an IT company to carry out all IT related tasks is very crucial, however adoption rate is quite slow. Things to consider while choosing a software company. Whether you want to replace your current software company or want to hire a new one, it is very crucial to discover a good company.
This may seem a very easy task. However, with the availability of many companies, finding an ideal software company may prove to be a daunting task. Why? Reason being is the fact that all companies will claim to provide the best and desired software services. Web Content Management. The Significant Role of Brand Management in any Company.
Brand is one of the most significant and valuable assets in any company that is responsible for building trust in the customer base. Just like other important assets, brand helps build on loyalty and create value for the customers, while fulfilling their needs and expectations. Brand can be thought as the face of any company that enforces people to buy their merchandise. Since brand plays an invaluable role in every company, small or big, thus one can't afford to ignore it. Some Common Mistakes a Mobile App Developer Can Make. Being a mobile app developer, you must have known to the fact that the success of any mobile application depends majorly upon its development and features.
Developers who are really good at programming and have the right skills can start developing mobile apps after knowing everything about the applications to be made. Seems easy! Software Testing For an Error Free Software. Web Design San Francisco. How to Choose the Best Web Development Company in California? Every company that offers IT services needs to find an ideal web development company that can help it boost its earnings. This may seem an easy task, however, if you fail in choosing the right company, then your company might move to the slippery slope of loss. Importance of Brand Management For a New Business. You have heard about many brands which are quite popular for several products such as Adidas and Nike that are famous for its wide range of sporting goods and other products.
In the present times, there are many dozens of brands in every field, whether you talk about food products, clothing products or any other thing. Software Testing Services. Get a Web Content Management System for Your Business. Being into the IT industry, you must have known to the term 'CMS'. CMS, short for Content Management System, is a powerful tool that plays an invaluable role in simplifying or managing the workflow of your business. There are, in fact, different types of content management systems available these days. A web content management system is recommended for all types of businesses, big or small. Since, it helps make the web publication work easier, therefore, you can take your business to the next level in the simplest possible ways.
Now, one can upload the contents without the need of any technical knowledge. With the effective use of web content management systems, one can now add extra functions to the present system, as plug-ins can be imported easily. How to Develop an Excellent Website For Your Business? The advancement in technology has completely changed the way how everything used to be handled earlier. Nowadays, every sector is slowly taking the online route to connect with the people, whether it is about banking, shopping clothing, paying your utility bills or doing any other thing.
Some Tips to Choose the Best Mobile App Development Company. Mobile App Development San Francisco. Brand Management Company.


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How does Arthur Miler create a dramatically effective ending?
Arthur Miller's A View from the Bridge is centred on a Brooklyn Longshoreman, Eddie Carbone and his family. He is a fairly simple, middle aged man of an Italian descent trying to make a good life for his adoptive daughter (actually his niece by marriage). The play is similar to a traditional Greek Tragedy in that there is a tragic hero whose fate is essentially unavoidable.
The main characters are realistically portrayed and as the audience we are able to empathise with them.
Beatrice is the wife of Eddie, who sticks with him through everything. She is aware of Eddie's feeling for Catherine from early on and often hints at how their relationship is strained for example when she asks Eddie "When am I going to be a wife again?" This shows tension between them, hinting at what might happen later on.
The two cousins are immigrants coming over from Italy, like many people living in New York in the late 1940's. Although their brothers, they have very different aims in coming to America.
Marco is shown as very noble, brave and strong. His strength and determination is displayed when he begins work in the docks. He works twice as hard as the other men and gets far more done. Although Eddie originally takes a liking to Marco, his strength is a threat to him.
Rodolfo, the young blonde Italian is the spark that sets of the whole chain of events. He does not have the same intentions as Marco which immediately arouses suspicion in Eddie, as we know he is very family orientated, this causes tension between that gradually builds up.
Throughout the play, we see changes in the characters that are unexpected.
We see B. develop from a quiet character into a much more outspoken, distraught one desperate for her husband to see sense, e.g. in the final scene she says "You want something else, Eddie, and you can never have her!" referring to Catherine. This shows that covering up the truth is no longer...


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Master the elements, control the storm.
£180.00 – £2,350.00
Master the elements, control the storm.
Master the elements, control the storm.
The INDRA range of menswear comes in a variety of evocative, hand-struck, hammered finishes.
The double oval INDRA cufflinks are handmade with luxuriously weighty front oval discs. They are the perfect size for fitting in a dress shirt cuff.
The unique oval bar fitting makes the INDRA Cufflinks wonderfully easy to handle and fit in to your shirt. Many of our clients prefer this to the more traditional cufflink chain.
Our cufflinks are available to order in Sterling Silver, 9ct & 18ct White Gold & Platinum. If you would like to order these Cufflinks in a different metal choice please get in touch and we can provide you with a custom quotation.
If you prefer cufflinks that have swivel back fittings, rather than double sided, then we have these available also in the INDRA collection.
Indra was the God of Lightning, Rain, Thunder and the Storms in ancient Vedic Traditions. He is the inspiration behind our INDRA collection.
All KATA Jewellery is handmade to order in our London studio. These cufflinks will ship within 1-2 weeks of purchase.
18ct White Gold, 9ct White Gold, Platinum, Sterling Silver
18mm x 13mm
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Posted Sunday, April 23, 2000 7:52 PM | Contributed by SFOhio
Superman Ultimate Escape at Six Flags Ohio is now testing. The ride takes you up and down many time and an explanation of what is available is online now at Six Flags Ohio Unofficial Site as well as a construction update, a new employee report and much more.
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RESULTS & PHOTOS – 2018 IFBB Elite Pro Cancun (Mexico).
The first official season for the 2018 IFBB Elite Pro league continues to get bigger and better.
Just a week after the IFBB Elite Pro Bodybuilding World championships, the action took place in Cancun, Mexico. As well in the same weekend the IFBB Elite Pro Female World Championships took place as well.
Read More: RESULTS & PHOTOS: 2018 IFBB Elite Pro Female World Championships
Read More: A night to remember at the 2018 IFBB Elite Pro Bodybuilding World Championships
The Cancun IFBB Elite Pro contest had various disciplines:
Men's Bodybuilding
Men's Physique
Bikini Fitness
In the bodybuilding class, Tomas Kaspar added another victory to his already successful 2018 season. Tomas had to battle a international line-up of ten athletes.
After finishing fifth at the IFBB Elite Pro Bodybuilding World Championships, Tomas made sure he made the right improvements to finish on top in Cancun.
The Men's Physique class is becoming one of the toughest categories in the IFBB Elite Pro league with athletes presenting fantastic physiques giving the judges a harder task to pick the final winners.
In Cancun it would be Dmytro Horobets, the most consistent winner in the IFBB Elite Pro league to take the top prize.
A fantastic line-up of nine athletes competed in the Men's Physique class. New athletes took to the stage showing that new IFBB Elite Pro card winners are active in competitions.
Dmytro continued his perfect run of victories by bringing to the stage a near perfect physique that is the perfect example for the Men's Physique class.
Marcos Felix from the Dominican Republic is a much taller athlete. He gave Horobets a good battle to finish in second while Edwin Rosas from Mexico finished in third.
The Bikini Fitness fitness category had a fantastic line-up of 18 beautiful athletes. The judges had their hands full selecting the final winners.
Ukraine's Oksana Bryhidyr was the eventual winner of the Bikini Fitness class. Estonia's Andra Vagur could not have started her IFBB Elite Pro career any better by placing second. Turkey's Denyz Saypinar finished in third.
The Bodyfitness category was dominated by the Mexican locals. Edith Vargas took the top prize with fellow Mexican Keytt Vera placing second. Brazil's Agnes Junqueira Crespo finished in third.
Daydania Mauricio from Curaçao was the winner of the fast growing Wellness category. This category is growing in popularity in each show organized. The Wellness class is very popular in Mexico with six contestants in a line-up of eight. Second place went to Beatriz Elena while third went to fellow Mexican Yvette Carreon. We are surely going to see more of these athletes in the future.
Download results in PDF format – Click HERE


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Unconscious Mutterings – First time
Written By: Gary on March 28, 2004 No Comment
Free association from Unconscious Mutterings.
- Pitbull::Mean Dog
- TD::TB (Too Bad)
- Carter::Jimmy
- Japan::Flag
- 50::Ways
- Streak::Blue
- Rifle::Skeet
- Trap::Bear
- Easter::Bunny
- Mitt::Baseball
Okay so it's the first time I did one of these… Not so sure I feel it's as insightful as some of the other meme things I've done…
I like some of the previous ones so I'll give it another try sometime.
Tags: Easter, meme, Unconscious Mutterings, word association


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Sony on Thursday has announced the launch of its latest mid-range smartphone, the Xperia XA1 Plus in India. The smartphone priced at Rs. 24,990 and will be made available starting from September 22 from all Sony Center and major retail stores in India in Black, Blue, and Gold colour options.
To recall, the smartphone was launched at the IFA 2017 in Berlin along with Xperia XZ1 and Xperia XZ1 Compac. The main highlights of the phone are 23MP rare camera with quick shutter release and Sony's Steady Shot stabilization on board and premium buit quality. The fingerprint scanner is side-mounted for better reach.
Another highlight of the smartphone is its battery optimization "The Sony XA1 Plus is designed to ensure a long lasting performance over the smartphone's lifetime. Stamina Mode extends the battery lifetime just when you really need it, whilst Qnovo Adaptive Charging technology and Battery Care work together to maintain the long-term health of the battery by monitoring its health and adjusting the charging current accordingly to avoid damage and maximise its lifespan" the company said in its release.
Sony Xperia XA1 Plus Specifications –
- Operating System – Android 7.0 Nougat
- Display – 5.5" IPD LCD Full-HD (1080×1920 pixels) 401ppi
- Processor – up to 2.3GHz 64-bit octa-core MediaTek 6757 Helio P20
- GPU – Mali T-880 MP2
- Internal Storage – 32 GB; expandable up to 256GB via microSD card
- Rear Camera – 23MP f/2.0, 24mm
- Camera Features – PDAF, LED flash, 1/2.3″ sensor size, HDR, panorama.
- Front Camera – 8 MP, f/2.0, 23mm, 1/4″ sensor size
- Battery – 3430mAh with Fast Charging Pump Express+ 2.0
- SIM – Dual SIM, Nano + Nano
- Connectivity – 4G VoLTE, Bluetooth 4.2, Wi-Fi 802.11 a/b/g/n/ac, dual-band, GPS, USB Type-C, NFC, 3.5mm Audio Jack
- Sensors – fingerprint scanner, accelerometer, proximity
- Dimensions – 155 x 75 x 8.7 mm
- Weight – 190g
For the latest tech news and updates follow TechnoCodex on Facebook, Twitter, Google+. Also share your thoughts with us by commenting below.


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A horse that was purchased for a measly $9,000 as a tried horse has gained a start in this years $3million dollar Caulfield Cup.
Go Dreaming who was purchased as a tried horse to target the Port Lincoln Cup back in 2014 will be the 18th horse to gain a spot in Saturday's Caulfield Cup field.
The current $401 rank outsider in the field has had 44 career starts with career earnings of over $300,000. His career highlight was a win in the Listed Japan Trophy at Morphettville over 2500 metres.
Have Your Say: Can Go Dreaming win the Caulfield Cup? – Leave a comment below.
The calls been made and his acc is in. He owes us nothing, but we owe it to him to have a shot And if the race is run on ❤ He'll run well pic.twitter.com/tB8XiuwPsj
— Grant Kluske Racing (@GKluskeRacing) October 10, 2016
Field: View the Caulfield Cup Field


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Greetings from Atlanta, GA! I am a new owner of a 1962 Pacer, and have to admit, it's a struggle. The bike alternates between starting up easily and just staring at me. As a novice mechanic, it's a very steep learning curve.
However as a rider-I can't imagine much more fun. I love the feel of the road vibrating up through the bike into my hands, the rumble of pavement shaking every bone in my body through the seat. After riding the Pacer the other day for about a 6 miles, I got on my wife's Honda Rebel, and felt lost. No feel, no one with the pavement.....like I was floating down the road without any excitement.
That said....this bike has some gremlins I'd love to exorcise. If anyone is in the Atlanta area and has experience with Harley lightweights,
I'd love to hear from you. The Tillotson carb that came on the bike was an MT42, and leaked like the Exxon Valdez cruising the Alaskan coast. On advice of someone here, I changed it to a Mikuni VM42 and it runs much better. Still incredibly hard to start...sometimes....and sometimes it cranks right up. There are other small little quirks that I'm sure an experienced person would know.
However-this is such a cool bike!
Richard Campbell
Atlanta, GA
1962 Harley Pacer


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Each day's newsfeed brings another dozen or so examples of how libs and lefties are losing their collective marbles and earning their epithets libtard and leftard. Here is just one recent example for your astonishment:
It was a story too dumb to be real: reports yesterday emerged from ESPN critic Clay Travis at Outkick the Coverage that ESPN had pulled an Asian announcer named Robert Lee off a University of Virginia college football game to avoid offending idiots. I have to admit, I didn't think it could be true. How unbelievably stupid do you have to be to think that someone whose name is similar to a Confederate general – albeit absent the all-important middle initial – would lead to triggering and upset viewers if he called a Charlottesville-based sporting event.
Please pray for these sick puppies. Unfortunately, many of them are not just sick but vicious to boot which suggests that harsher treatments may be called for.


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Saniku / Dusar
The owner-managed German traditional company develops, produces and distributes high-quality and durable sanitary products to sanitary traders and studios.
Special features
A wide range of design possibilities for the theme of the bathroom and WC are to be displayed to the specialists. The architecture must at the same time be appealing, functional and structural stable to withhold the weight of heavy glass moving parts other bathroom furniture.
- Exhibition design
- draft
- architecture
- graphics
- catering
- assembly
- dismantling
- storage
- logistics
- assistance during the run time


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Dr Muneeb Choudhry MBBS DRCOG DFSRH DGM DIPOccMed MRCGP PGCert
Dr Muneeb Choudhry qualified from St. Georges, University of London in 1998 and completed his GP training in 2003 in Surrey. He travelled to remote and rural Australia after this as part of the Programme for Aboriginal Health. Following this he completed a short service commission as a Medical Officer in the Royal Air Force. Since then he has become a GP trainer, a GP appraiser and is an honorary lecturer at St. Georges, University of London with an interest in prescribing. He has developed practical expertise in minor surgery, joint injections, acupuncture, circumcisions, plastics and aesthetic procedures. Dr Choudhry is qualified in Occupational Medicine as well as Mediation. He holds additional posts as Learning Disability Lead in two CCGs in South London.
Dr Rabia Ishaque
Dr Mohammed Zafar Munshi MBBS MRCGP BSc DRCOG
Dr Munshi graduated in 2010 from King's College London with a distinction in clinical practice. He performed his post graduate training in North East London, attained a Diploma in Obstetrics and Gynaecology in 2013 and completed his GP training in 2015. Dr Munshi has a special interest in chronic disease management and ENT and continues to develop his skills in these areas.
Dr Abir Shaikh MBBS MRCGP BSc(Hons)
Dr Shaikh graduated in 2010 from University College London. He completed his post graduate training in North East London and obtained his MRCGP in 2015. His clinic interests include acute illness and mental health. Dr Shaikh is passionate about making a significant improvement to the quality of patient care, particularly in his areas of special interest.
Dr Jazeb Razaq MBBS MRCGP BSc
Dr Razaq graduated from University College London in 2010. He completed his postgraduate training with the London Deanery. His areas of interest include geriatric medicine, urology and mental health. Dr Razaq is committed to constantly enhancing his skills by regularly engaging in training as well as clinical meetings, focused on providing high-quality patient care.


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Manhattan Upper West Side Hotel For Sale
Hotel residing at the gateway to the Upper West Side
This Hotel reflects the earth tones and modernism of our famed neighbors.
This Mahhattan, New York hotel offers sophisticated comfort and bold decor among many of their upscale amenities and superior guest services.
The Hotel's coveted location puts guests within convenient proximity to some of New York's top attractions.
For instance, guests can walk to overlook the renowned Lincoln Center which includes the Metropolitan Opera House, Jazz at Lincoln Center, and Alice Tully Hall, all host to top live performances and major global events in the world all year-round.
Guests will also find Central Park and Columbus Circle less than a few short blocks away.
~425 Richly Appointed Guest Rooms
Accessible Rooms (ADA)
Roof Top Pool and Bar (seasonal)
Indoor/Outdoor Roof Top Event Space with Fireplace
Renoned Restaurant
Lobby Bar
Complimentary Fitness Center
Meeting Space for up to 250 People BR>
The information contained herein contains confidential and/or privileged material. Any review, retransmission, dissemination or other use of, or taking of any action in reliance upon, this information by persons or entities other than the intended recipient will be prohibited. The information contained herein has been obtained from sources believed to be reliable. While we do not doubt its accuracy, we have not verified it and make no guarantee, warranty or representation about the accuracy or completeness of the information. As a buyer, it is your responsibility to independently confirm its accuracy and completeness. Any projections, opinions, assumptions or estimates used are for example only and do not represent the current or future performance of the property. The value of this property to you depends on factors which should be evaluated by your tax, financial and legal advisors. You and your advisors should conduct a careful, independent investigation of the property to determine to your satisfaction the suitability of the property for your needs. We have no knowledge of this offering other than the information received from Seller or their representatives. We are neither your agent or an agent for the seller. We will not participate in the negotiation of the purchase price or attend the showing of this property. As a buyer, you will be required to indemnify us and hold us harmless from any kind of claim, cost, expense, or liability arising out of your investigation and/or purchase of this property.


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Mercury MerCruiser #29 Marine Engines D1.7L DTI Service Repair Manual 2001-UP
This manual can be used by anyone from a first time owner/amateur to a professional technician. Easy to read type, And give you all the information needed to do the procedure correctly. Keep this shop manual handy and use it often. Performing routine, preventive maintenance will save you time & money by helping to prevent premature failure and unnecessary repairs.
MCM Model – Serial Number Covered:
D1.7L DTI – S/N: OM055001 and Above
Table of Contents:
SECTION 1 – Important Information
A – General Information
B – Maintenance
C – Troubleshooting
SECTION 2 – Removal and Installation
A – MCM (Sterndrive) Models
SECTION 3 – Engine
A – D1.7L DTI Engine Mechanical
SECTION 4 – Electrical System
A – Starting System
B – Charging System
C – Glow Plug System
D – Instrumentation
E – Wiring Diagrams
SECTION 5 – Fuel System
A – Fuel Filter
B – Fuel Injectors
C – Injection Pump
SECTION 6 – Cooling System
A – Closed Cooling
SECTION 7 – Intake and Exhaust System
A – Intercooler
B – Exhaust
C – Turbocharger
A – Power Steering System
File Format: PDF
Compatible: All Versions of Windows & Mac
Language: English
Requirements: Adobe PDF Reader


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Hey there! I know you know, but…. this Ludum Dare was aweeesomee!
I have played a lot of great games, very original entries!
A lot of these games NEED to be finished an published anywhere!
People deserve to play them!
Some of the games that i've played have a "post compo" version, so a lot of the jam-bugs are gone, which is nice!
My game, for instance, is just like it was when we finish it for the jam, so it still has a lot of bugs and questionable things haha
Anyway, i really want to play more games, and i will.
If you want to share your game's link in the comments section it would be really nice so i can find it and play it faster! 😀
The game I made is >ADAPT<
Is a minimalistic platformer with a shapeshifting mechanic, where you have to change your shape to overcome a series of random obstacles.
Each level is procedurally generated! (with more variants the randomness would be way cooler, but i think it works – just because is a jam game)
You can, also, play two-player mode with an additional joystick! (which is the very-best way to play this game!)
Check it out! And if you do, please leave me a comment there so i can find your game later! 😀
- WebGL is weird, try to play the desktop version if you can!
- If you fall from a long distance, you'll die and respawn immediatly at the last checkpoint. That is very unclear in the game 😐
- Yes, it has a lot of bugs, sorry e.e
- Yes, it looks like Thomas Was Alone or 140. Is nothing like those games anyway (just the platforming aspect, of course) but yes. You're a very good observer!
- When you have the "circle-shape" you get smaller and smaller while you move. If you get VERY small, you will die and respawn immediatly. That is (also) not clear at all.
- When you get to the finish line, the game tells you "GAME OVER…", just because the game is over, not because you lose.. I didn't give enough thought to it as you can guess e.e


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With the visual ingenuity of PRESS HERE and the emotional resonance of WHAT DO YOU DO WITH A PROBLEM?, this wise and timely book about the fragile art of personal connection will strike a chord with readers of all ages.
In the era of social media, communication feels both more anxiety-producing, and more inescapable, than ever before. This clever, comforting picture book debut explores the challenges and joys of self-expression and social connection.
Using an imaginative visual metaphor to bring to life how we send out (ping!) and receive (pong!) communications, feelings, and ideas, Ani Castillo's words and pictures combine to create an empowering, inspiring message for anyone who has experienced the fear of meeting new people, sharing opinions, and expressing emotion.
With a charming gift book trim size, an eloquent message, and a lot of heart, here is an instant classic that parents can give their children -- and adults can give each other. Fans of Peter Reynolds and Todd Parr will appreciate this positive message delivered in an artful, accessible package.