text:
Endocannabinoids control hippocampal inhibitory synaptic transmission through activation of presynaptic CB1 receptors. During depolarization-induced suppression of inhibition (DSI), endocannabinoids are synthesized upon postsynaptic depolarization. The endocannabinoid 2-arachidonoylglycerol (2-AG) may mediate hippocampal DSI. Currently, the best studied pathway for biosynthesis of 2-AG involves the enzyme diacylglycerol lipase (DAGL). However, whether DAGL is necessary for hippocampal DSI is controversial and was not systematically addressed. Here, we investigate DSI at unitary connections between CB1 receptor-containing interneurons and pyramidal neurons in CA1. We found that the novel DAGL inhibitor OMDM-188, as well as the established inhibitor RHC-80267, did not affect DSI. As reported previously, effects of the DAGL inhibitor tetrahydrolipstatin depended on the application method: postsynaptic intracellular application left DSI intact, while incubation blocked DSI. We show that all DAGL inhibitors tested block slow self-inhibition in neocortical interneurons, which involves DAGL. We conclude that DAGL is not involved in DSI at unitary connections in hippocampus.
Endocannabinoids mediate both short- and long-term plasticity at many synapses in the brain. The first form of synaptic plasticity in which endocannabinoids were shown to be involved is hippocampal depolarization-induced suppression of inhibition (DSI) (Wilson and Nicoll, 2001). Hippocampal DSI occurs at a subset of inhibitory synapses onto pyramidal neurons coming from CB1 receptor (CB1R)-containing interneurons. At these synapses, a postsynaptic depolarization leads to calcium-dependent synthesis of endocannabinoids, which subsequently travel to the presynaptic inhibitory terminal. Here, endocannabinoids activate the G-protein coupled CB1R, thereby reducing presynaptic release probability for tens of seconds. The endocannabinoid 2-arachidonoyl glycerol (2-AG) (Sugiura et al., 1995) has been proposed to mediate hippocampal DSI, since inhibiting 2-AG degradation increases the duration of DSI (Kim and Alger, 2004; Makara et al., 2005; Hashimotodani et al., 2007). However, sn-1-diacylglycerol lipase (DAGL) α, the major enzyme catalyzing 2-AG formation in the adult brain (Bisogno et al., 2003) has not been found opposite symmetrical, GABAergic synapses in hippocampus (Katona et al., 2006). Furthermore, studies in which DAGLs have been targeted pharmacologically reported conflicting results. Blocking these enzymes pharmacologically suppresses hippocampal DSI in some studies (Hashimotodani et al., 2007) but not in others (Chevaleyre and Castillo, 2003; Edwards et al., 2006; Szabo et al., 2006). So far, the only study showing pharmacological evidence for DAGL involvement in hippocampal DSI was performed on cultured neurons. This raises the question whether DAGL is involved in hippocampal DSI at intact synapses. Here, by using three chemically different DAGL inhibitors, we have investigated DAGL involvement in hippocampal DSI at unitary connections between CB1R-containing interneurons and CA1 pyramidal neurons.
Materials and Methods
Slice preparation.
All experiments were approved by the Animal Ethical Committee of the VU University Amsterdam, in accordance with Dutch and European law. For DSI experiments, 14- to 21-d-old wild-type C57Bl6 mice or CB1R−/− mice (Marsicano et al., 2002) were decapitated. Transverse hippocampal slices (300 μm) were sectioned in ice-cold solution containing (mm): 126 NaCl, 3 KCl, 10 glucose, 26 NaHCO3, 1.2 NaH2PO4, 1 CaCl2, and 3 MgCl2 (carboxygenated with 5% CO2/95% O2). For slow self-inhibition (SSI) experiments, sagittal slices containing somatosensory cortex were cut from 21- to 28-d-old FVB-Tg(GadGFP) 45704Swn/J mice expressing EGFP under control of the mouse Gad1 gene promoter (The Jackson Laboratory stock no. 003718), thereby labeling a subset of somatostatin-positive interneurons in hippocampus and neocortex (Oliva et al., 2000). Slices were maintained at 33°C for ∼30 min and recorded at room temperature (20−22°C) in a similar solution, but now with 2 mm CaCl2 and 2 mm MgCl2.
Paired recordings of CB1R-containing interneurons and CA1 pyramidal neurons.
Cellular recordings were performed from 2–6 neurons simultaneously using borosilicate glass pipettes with resistance of 3–5 MΩ, containing the following (in mm): 70 K gluconate, 70 KCl, 4 Mg-ATP, 4 phosphocreatine, 0.4 GTP, 0.5 EGTA and 10 HEPES (pH 7.3, KOH). In synaptically connected neurons, suprathreshold stimulation of the presynaptic interneuron evoked a GABAAR mediated IPSP/IPSC in the postsynaptic CA1 pyramidal neuron. Because of the high intracellular chloride concentration, IPSCs were observed as inward currents, while IPSPs were depolarizing. Presynaptic cells were stimulated with a pair of two suprathreshold current pulses (at ∼10 Hz). Trains were delivered with intervals of 5 s. Recording and stimulus delivery was performed using standard electrophysiological equipment.
SSI recordings in neocortical interneurons.
For experiments on SSI, EGFP expressing interneurons in somatosensory cortex were selected using an UV light source and fluorescence imaging. Extracellular and intracellular solutions were similar as for paired recordings, but to exclude contributions from synaptic conductances DNQX (10 μm), GABAzine (100 μm), and dl-AP5 (100 μm) were added to the extracellular solution.
Some recorded interneurons were filled with biocytin (0.5%), and slices were fixed and resliced after recording. Sections were stained using the antibodies goat-anti-streptavidin Alexa Fluor 488 conjugate (1:200) and the primary antibody rabbit-anti- CB1R (diluted 1:1000 in TBS-TX) (Tsou et al., 1998). In a second step, sections were incubated with the secondary antibody Alexa Fluor 594 goat anti-rabbit IgG (1:200). Colocalization between biocytin and CB1R was determined using a Leica confocal laser-scanning microscope (Leica), the Huygens system (Scientific Volume Imaging), and the Amira isosurface module (Konrad Zuse Center for Information Technology, Berlin, Germany). Care was taken to prevent false positives, incomplete signal separation and crosstalk of dyes. Neuron reconstructions were performed under an up-right microscope (Leica) using a 40× objective with Neurolucida software (Neurolucida, MicroBrightField).
Of tetrahydrolipstatin (THL), RHC-80267 (Sigma-Aldrich) and OMDM-188 (Ortar et al., 2008) appropriate stock solutions were prepared in DMSO (Final concentration <0.2%). Slice-incubation was done in the slice chamber for at least 30 min before recordings started, with the same compound concentration present extracellularly. For intracellular application, intracellular equilibration was allowed for at least 20 min after whole-cell break-in (see Figs. 3, 4). Vehicle controls with intracellular or extracellular DMSO were interleaved with normal control experiments. Because we observed no vehicle effects, all control experiments were grouped.
All analysis was done using custom written procedures in Igor Pro (Wavemetrics). Statistical analysis was done either using two-sided Student's t test (for single comparisons; α = 0.05), or ANOVA with post hoc Dunnett's test (for multiple comparisons; α = 0.05).
Simultaneous whole-cell recordings were made from CA1 pyramidal neurons and interneurons located in stratum radiatum, close to the border with stratum pyramidale (Fig. 1). Cell bodies of selected interneurons had a multipolar appearance and their firing pattern upon current injection showed considerable spike-frequency adaptation (Fig. 1C). To confirm the presence of CB1Rs in the studied interneurons, we used biocytin staining and immunostaining for the CB1R in a subset of interneurons (Fig. 1A,B). All interneurons showed substantial colocalization of biocytin and CB1R immunoreactivity in axons (n = 5/5) (Fig. 1B).
Inhibitory connections were activated by evoking two action potentials (APs) at ∼10 Hz in the interneuron, while recording IPSCs in the CA1 pyramidal neuron (voltage-clamped at −70 mV) (Fig. 1D). In cell pairs showing an inhibitory synaptic connection we tested for the presence of DSI. Two APs were evoked in the interneuron once every 5 s (0.2 Hz). After recording 50 control responses, the subsequent 50 responses were each preceded by a depolarizing step (1 s to 0 mV) to the postsynaptic pyramidal cell (depolarization period) (Fig. 2A). For IPSCs evoked after such a depolarizing step, the IPSC amplitude was reduced to 36.0 ± 2.6% of control (Fig. 2A–C) (p = 0.0001; n = 7), meaning that there was 64.0 ± 2.6% DSI. Amplitude reduction was accompanied by a strong increase in synaptic failure rate (Fig. 2D) (control 30.0 ± 4.6%; depolarization 49.4 ± 5.1%; p = 0.024). After the depolarization period, both IPSC amplitude and failure rate partially recovered, respectively to 76.3 ± 3.1% and 37.1 ± 5.0% (Fig. 2A–D).
The increase in failure rate during the depolarization period is in support of a presynaptic locus of suppression of inhibition. Analysis of the coefficient of variation (CV) of the IPSC amplitudes (Faber and Korn, 1991) showed that the ratio between CV2 during DSI versus CV2 under control was proportional to the relative change in synaptic amplitude (Fig. 2E) (averaged CV−2DSI/CV−2control: 0.38 ± 0.03; amplitude ratio: 0.36 ± 0.03), confirming that the modulation is presynaptic in origin. In CB1R knock-out (CB1R−/−) mice, we did not observe a significant reduction in IPSC amplitude during the depolarization period, and failure rate was unaffected (supplemental Fig. S1, available at www.jneurosci.org as supplemental material). Together, these findings suggest that DSI at these unitary synapses occurs through a decreased presynaptic release probability by CB1R activation.
Activity-dependent endocannabinoid synthesis in several brain regions depends on the DAGL enzymatic activity (Melis et al., 2004; Safo and Regehr, 2005; Szabo et al., 2006). To test for the involvement of DAGLs in hippocampal DSI, we used several DAGL inhibitors. Slices were incubated with the novel potent DAGL inhibitor OMDM-188 (2 μm; Ortar et al., 2008) for at least 30 min before commencing paired recordings in the presence of OMDM-188. Under these conditions, significant DSI was still observed (amount of DSI: 46.2 ± 5.3%; n = 6; p = 0.016) (Fig. 3A), and was accompanied by an increase in failure rate (control: 51.7 ± 1.6%; depolarization: 67.7 ± 2.2%; p = 0.03) (Fig. 3A). The amount of DSI did not differ significantly from control conditions (p > 0.05) (Fig. 3F). Similarly, slices incubated and recorded with the established DAGL inhibitor RHC-80267 (50–70 μm) also showed significant DSI (87.5 ± 2.4%; n = 5; p = 0.009) (Fig. 3B), and an increase in failure rate (control: 54.0 ± 4.7%; depolarization: 92.0 ± 0.6%; p = 0.03) (Fig. 3B).
Recently, several studies have reported opposing effects of extracellular application of the DAGL inhibitor THL on hippocampal DSI (Szabo et al., 2006; Edwards et al., 2008; Hashimotodani et al., 2008). It has been shown that intracellular application of low concentrations of THL is very effective at inhibiting DAGL activity in striatum (500 nm) (Melis et al., 2004) and cerebellum (2 μm) (Safo and Regehr, 2005). Therefore, we added THL (5 μm) to the intracellular solution of the postsynaptic pyramidal neuron, without applying THL extracellularly. To allow intracellular diffusion of THL the depolarization protocol was started at least 20 min after establishing the whole-cell configuration at the pyramidal neuron. Intracellularly applied THL did not affect DSI (70.9 ± 1.6%; n = 15; p = 0.02) (Fig. 3C) (compared to control DSI: p > 0.05) (Fig. 3F). Accordingly, failure rate significantly increased upon depolarization (control: 24.9 ± 1.6%; depolarization: 66.8 ± 2.0%; p < 0.001) (Fig. 3C). Even with a 1 h waiting period for intracellular THL diffusion, DSI was clearly observed (Fig. 3E), suggesting that the ineffectiveness of intracellular THL was not due to incomplete intracellular diffusion. Surprisingly, when slices were incubated extracellularly with higher concentrations of THL (10 μm), DSI was abolished (17.2 ± 2.1%; n = 6; p = 0.10) (Fig. 3D), and failure rate was not affected by depolarization (control: 51.8 ± 3.8%; depolarization: 51.1 ± 3.4%; p = 0.86) (Fig. 3D). To assess whether extracellularly applied THL affected CB1R signaling downstream of the CB1 receptor, we tested the effect of THL on the suppression of IPSCs by the CB1R agonist WIN55,212-2 (2 μm). IPSC suppression by WIN55,212-2 was unaffected in slices incubated in THL, showing that THL incubation did not interfere with CB1R signaling down stream of the receptor (supplemental Fig. S2, available at www.jneurosci.org as supplemental material).
These observations raise the possibility that the other treatments were not effective in inhibiting DAGLs due to suboptimal experimental conditions such as lack of cell penetration. To exclude this possibility, we used the above procedures and inhibitors to block DAGLs in the well-established phenomenon of SSI of neocortical interneurons (Bacci et al., 2004). SSI is induced by repetitive AP firing of somatostatin-positive low-threshold spiking (LTS) interneurons in neocortex (Fig. 4). It is triggered by endocannabinoid-mediated activation of postsynaptic CB1Rs, which in turn activate a prolonged K+ conductance. Recently, it was shown that DAGL inhibition effectively abolishes SSI (Marinelli et al., 2008). We made whole-cell recordings of interneurons in mice expressing EGFP in somatostatin-positive interneurons (Oliva et al., 2000) (Fig. 4A). Upon hyperpolarizing current steps these neurons showed a clear rebound depolarization that regularly induced a rebound AP (Fig. 4A), characteristic of LTS interneurons. After recording resting membrane potential for several minutes, LTS interneurons were stimulated with 10 trains of 60 APs at 50 Hz each (Marinelli et al., 2008). This stimulation induced a clear, long-lasting drop in membrane potential (SSI; ΔVm: −4.30 ± 0.96 mV; n = 12; p = 0.001) (Fig. 4B). SSI was absent in CB1R−/− mice, showing that it is mediated by CB1Rs (supplemental Fig. S3, available at www.jneurosci.org as supplemental material). All pharmacological interventions reducing DAGL-activity effectively blocked SSI (Fig. 4,C–F). When slices were incubated and recorded in OMDM-188 (2 μm), SSI was absent (ΔVm: −0.79 ± 0.76 mV; n = 8; p = 0.33) (Fig. 4C). Incubation with RHC-80267 (70 μm) also effectively blocked SSI (ΔVm: 0.63 ± 1.34 mV; n = 5; p = 0.66) (Fig. 4D). Finally, intracellular application of THL (5 μm) also effectively blocked SSI (ΔVm: −0.35 ± 0.98 mV; n = 6; p = 0.74) (Fig. 4E).
Therefore, we conclude that the lack of effect of DAGL inhibitors on DSI at the interneuron to CA1 pyramidal neuron unitary connections that we studied was not due to suboptimal experimental conditions. Taken together, our data suggest that DSI at these unitary connections in hippocampus occurs without the involvement of DAGL activity.
Biosynthetic pathways controlling endocannabinoid formation in hippocampal DSI have remained unclear. We systematically addressed involvement of DAGLs in DSI at identified unitary synaptic connections. We show that several known DAGL inhibitors do not affect DSI at these hippocampal synapses, while they abolish SSI in neocortical interneurons (Fig. 4), a process known to require DAGL activity (Marinelli et al., 2008). Our findings strongly suggest that DAGL is not involved in hippocampal DSI.
Recently, studies have reported opposing effects of the DAGL inhibitor THL on DSI (Szabo et al., 2006; Edwards et al., 2008; Hashimotodani et al., 2008). Intracellular application of THL effectively inhibits DAGL activity in VTA, cerebellum, and neocortex (Melis et al., 2004; Safo and Regehr, 2005; Marinelli et al., 2008). We found that intracellular postsynaptic application of THL did not affect DSI. This lack of effect is unlikely to be due to experimental conditions, because intracellular THL application successfully blocked SSI, confirming a previous report by Marinelli et al. (2008). Therefore, these results confirm the findings with other DAGL inhibitors, and rule out involvement of DAGL in hippocampal DSI. This raises the question by what mechanism extracellular THL application blocks hippocampal DSI (Edwards et al., 2008; Hashimotodani et al., 2008). Hashimotodani et al. (2008) and Szabo et al. (2006) ruled out indirect effects of THL on either CB1R signaling or calcium influx necessary for DSI induction. Likewise, we show that slice incubation with THL does not affect CB1R signaling (supplemental Fig. S2, available at www.jneurosci.org as supplemental material). At present, the mechanism by which extracellular THL blocks hippocampal DSI remains elusive. Given the absence of effects of OMDM-188, RHC-80267, and intracellular THL on DSI, we argue that extracellular THL does not block DSI through inhibition of DAGL.
A recent study showed that hippocampal DSI during cholinergic receptor activation requires signaling by nitric oxide (NO) (Makara et al., 2007). This opens the possibility that under these conditions endocannabinoid synthesis takes place outside of the postsynaptic neuron, perhaps in the presynaptic terminal, and that NO is the messenger emanating from the postsynaptic neuron. If the downstream target of NO would be sensitive to THL, this might explain why extracellular application of THL blocks DSI, while postsynaptic application is ineffective. However, in the same study from Makara et al. (2007) it was shown that NO is not involved in DSI in the absence cholinergic receptor activation. In agreement with this, we find that DSI at unitary connections, in the absence of cholinergic receptor activation, is not affected by incubation with the NO-synthase inhibitor Nω-Nitro-l-arginine methyl ester (supplemental Fig. S4, available at www.jneurosci.org as supplemental material). Therefore, NO involvement cannot explain the discrepancy between the effects of extracellular and postsynaptic THL application in our experiments.
It has been suggested that DSI might involve a pre-formed 2-AG pool (Edwards et al., 2006), and that DAGLs are involved in filling this pool, not in the actual DSI process. However, when blocking DAGLs, we did not observe a reduction in the amount of DSI during 50 subsequent depolarizations, although this would be expected when depleting a pre-formed pool of 2-AG. Therefore, if DSI involves a pre-formed pool of 2-AG, this pool must be quite substantial and stable.
Recent studies suggested that 2-AG, and not anandamide, is the endocannabinoid mediating hippocampal DSI. This conclusion was based on the ability of inhibitors of monoacylglycerol lipase, the enzyme that breaks down 2-AG, to prolong hippocampal DSI (Makara et al., 2005; Hashimotodani et al., 2007). Furthermore, inhibition of fatty-acid amide hydrolase, the enzyme responsible for anandamide breakdown, does not affect the time course of hippocampal DSI (Kim and Alger, 2004; Makara et al., 2005; Hashimotodani et al., 2007). However, while studies of DAGL distribution in hippocampus have shown that sn-1-DAGL-α is perfectly positioned for production of 2-AG as retrograde messenger at excitatory synapses (Katona et al., 2006; Yoshida et al., 2006), sn-1-DAGL-α was not found opposite symmetrical, GABAergic synapses (Katona et al., 2006). Together with our results, this suggests that sn-1-DAGL-α is not involved in DSI at inhibitory synapses in hippocampus. This may suggest that 2-AG is produced by different mechanisms at these synapses, involving another, hitherto unknown, synthesis pathway, such as the lysophosphatidic acid-dependent route (Nakane et al., 2002). Alternatively, it may suggest that 2-AG is not the endocannabinoid mediating DSI at unitary inhibitory synaptic connections in hippocampus.
The Department of Integrative Neurophysiology is financially supported by NeuroBsik (www.neurobsik.nl), NWO and the VU University board. We thank B. Lutz for providing us with CB1R−/− mice, K. Mackie for providing us with the CB1R antibody, N. Lozovaya and T. Nevian for helpful discussions, and J. Timmerman and T. Lodder for excellent technical support. R.M., A.B.B., N.B., and H.D.M. designed the experiments. R.M., G.T.-S., T.S.H., and J.C.L. performed experiments; C.B.C. performed immunohistochemistry and reconstructions; T.B. and V.D.M. synthesized OMDM-188; R.M. analyzed the data; R.M. and H.D.M. wrote the manuscript; all authors commented on the manuscript.
- Correspondence should be addressed to either of the following: Huibert D. Mansvelder, Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, De Boelelaan 1085, Room C-440, 1081 HV Amsterdam, The Netherlands, huibert.mansvelder{at}cncr.vu.nl; or Nail Burnashev, Institut de Neurobiologie de la Méditerranée, Parc Scientifique de Luminy, 163 Roude de Luminy, BP13, 13273 Marseille, France, nail.burnashev{at}inmed.fr


text:
First Contact Science Fiction Books
Commonwealth Saga
by Peter F. Hamilton
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Critics have compared the engrossing space operas of Peter F. Hamilton to the classic sagas of such sf giants as Isaac Asimov and Frank Herbert. But Hamilton's bestselling fiction—powered by a fearless imagination and world-class storytelling skills—has also earned him comparison to Tolstoy and Dickens. Hugely ambitious, wildly entertaining, philosophically stimulating: the novels of Peter F. Hamilton will change the way you think about science fiction. Now, with
Pandora's Star
, he begins a new multivolume adventure, one that promises to be his most mind-blowing yet.
The year is 2380. The Intersolar Commonwealth, a sphere of stars some four hundred light-years in diameter, contains more than six hundred worlds, interconnected by a web of transport "tunnels†known as wormholes. At the farthest edge of the Commonwealth, astronomer Dudley Bose observes the impossible: Over one thousand light-years away, a star . . . vanishes. It does not go supernova. It does not collapse into a black hole. It simply
. Since the location is too distant to reach by wormhole, a faster-than-light starship, the
Second Chance
, is dispatched to learn what has occurred and whether it represents a threat. In command is Wilson Kime, a five-time rejuvenated ex-NASA pilot whose glory days are centuries behind him.
Opposed to the mission are the Guardians of Selfhood, a cult that believes the human race is being manipulated by an alien entity they call the Starflyer. Bradley Johansson, leader of the Guardians, warns of sabotage, fearing the Starflyer means to use the starship's mission for its own ends,.
Pursued by a Commonwealth special agent convinced the Guardians are crazy but dangerous, Johansson flees. But the danger is not averted. Aboard the
Second Chance
, Kime wonders if his crew has been infiltrated. Soon enough, he will have other worries. A thousand light-years away, something truly incredible is waiting: a deadly discovery whose unleashing will threaten to destroy the Commonwealth . . . and humanity itself.
Could it be that Johansson was right?
From the Hardcover edition.
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(plural Dutch wives)
- A long body-length pillow that can be held or wrapped around one's body while sleeping
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CLEVELAND, OH (WOIO) - "Sunny Side Up" is a daily morning talk show that airs on CBS-Cleveland 19 News featuring Wake Up Cleveland's Neeha Curtis and Julian Glover.
On Tuesday's edition of "Sunny Side Up," Neeha and Julian will be discussing the rising cost of healthcare.
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The show features discussions on trending topics, guests, and more.
Copyright 2019 WOIO. All rights reserved.


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Trying to find a weapon to reinforce our arsenal against the bad guys is always an interesting job.
There are on the market several new or quite new technologies, there are also old technologies presented in a new fashion or implemented in a new way.
One of the most interesting areas is the use of reputation services.
Reputation services are a way to determine if a source IP or service (that can be translated as IP and Port, IP and URL, and so on) is a vector of threat or not.
Trying to understand if a source is trustworthy or not is a quite difficult job, mainly because we are not in a black or white environment where a source is absolutely and completely bad forever and ever, but we are in an environment where things change rapidly.
When talking about reputation we should understand a couple of things:
First of all reputation is a rating service and not a blacklist service. Is a way to express in a metric how "risky" is to connect to a specific source.
Nothing is absolutely trustable, than means that everything can be compromised and be, form time to time, source of risk. Nevertheless all the compromised sources are 100% un-trustable, since they can deliver also legitimate contents.
An IP address can deliver thousands of different services, not all those service can be compromised at the same time. As a matter of fact a source can be trustable for smtp and not trustable for http.
The reason behind this is quite simple, TCP\IP suite has been designed to provide connection to a great variety of applications and services.
To provide this the TCP\IP suites has been build to provide a common addressing schema (The IP address and the port) able to manage different protocols that could require a connected (TCP) or connectionless (UDP) transaction with the counterpart. All the protocols related to TCP\IP are independents one to another, and generally are associated to different daemons or programs that can generate traffic through them.
PAT, NAT and DHCP are also a reasonable reason to have different behaviors coming from a single IP.
A single public IP can be associated to different physical or logical service sources that can be mapped, for example, through Port Address Translation in order to expose different services generated by different servers with a private IP addressing schema.
The real challenge with reputation services is that a good reputation service is related to the ability to monitor the widest possible IP area and have enough historical data to provide projection and analysis.
This is a mandatory requirement because we cannot have direct control over every single IP or every single daemon that is behind an IP service so we can understand if something is going bad or good only monitoring its activity.
Cisco's approach to this problem has recently evolved to the Cisco SIO integration: the previous Cisco network has been merged with Cisco Ironport Senderbase network and recently with the Scansafe one. This new merged network is called Cisco Sensorbase network.
The idea is to provide an extensive monitoring platform of what happens on the internet, adding data from firewalls, IPS, different kind of traps and sensors, web browsing, spam analysis, malware analysis and so on, correlate all those data and provide reputation outputs.
Think of Cisco SIO as the world's largest cooperative global security ecosystem, using more than 700,000 live feeds from linked Cisco email, web, firewall, and intrusion prevention systems (IPSs).
1) Cisco SensorBase collects raw event data from more than 700,000 globally linked sensors in Cisco IPS devices, firewalls, and web security and e-mail security devices, as well as data from more than 600 third-party feeds. SensorBase examines more than 30 percent of the world's e-mail, thanks to strategically located "honey-pot" accounts equipped with e-mail addresses publicized on lists that spammers might use.
2) The Cisco SIO Threat Operations Center weights and processes the data. When necessary, Cisco security experts reverse-engineer malware and other Internet threats. Engineers also collect, research, and supply information about security events that have the potential for widespread impact on networks, applications, and devices.
3) When the data is ready for deployment, Cisco SIO mechanisms dynamically deliver updates to Cisco firewall, web, IPS, and email devices, and Cisco IntelliShield vulnerability aggregation and alert services. Cisco SIO also sends security best practice recommendations and community outreach services to Cisco customers.
Reputation provided with this system is used to feed Cisco web and email security products as well as Cisco IPS devices. but SIO output feed not only reputation but also antibotnet engine on Cisco ASA as well as L4TM engine on Cisco WSA.
But what does this reputation look like?
Basically for email and web security the reputation score is just a number in a range (–10.0 _ +10.0).
–10 means you have a devil at your door, while values +10 means an angel in knocking at your window. all the values in between means we have to deal with sources that can have different risk rating.
If we are working on a e-mail security solution we can use this risk rating to manage smtp connection.
What we can do is to modify the TCP accepting behavior doing an effective shaping of the traffic. In other words we can tell to the system to reject connection that are below a specific value (I usually suggest –3), and limit the number of accepted connections and email sent per smtp connection in a specific range.
If we are working with a web security solution we can decide how we want to process the web traffic we received.
Once again we can block connections with a reputation below a specific value, force malware inspection and\or https inspection in specific ranges.
While the reputation value is an attribute given by SIO the policy is created by the Security Manager or administrator.
On the IPS solution (with IPS 7.0) Security managers can use SensorBase data in two ways. Reputation filtering lets you block all traffic from IP addresses with an extremely bad reputation. This is done regardless of traffic type -- all traffic from these sites will be blocked.
This basic use of reputation filters isn't new, but what's interesting is that Cisco will use this reputation data to change the Risk Rating of security events identified by the IPS. In other words, an event linked to a 'bad' IP address will result in an even higher Risk Rating.
"Risk Rating" is a Cisco-proprietary value, from 0 to 100, that is computed for every event identified by the IPS. Risk Rating lets you prioritize events and decide what to look at and what to ignore.
In Cisco's IPS products, every event has a Risk Rating and the security manager generally defines three bands of risks: low, medium, and high.
For each of the bands, you can then select a set of actions, from logging that an event occurred to actively blocking all traffic from a particular IP address for some period of time. Risk Ratings aren't new -- what's new is the addition of reputation information in 7.0.
Global Correlation Inspection raises the Risk Rating for any event when one of the IP addresses involved has a bad reputation.
The difference between Reputation Filtering and Global Correlation Inspection is pretty important: with Reputation Filtering turned on, an extremely bad reputation of -10 will cause all traffic to be dropped. With Global Correlation Inspection turned on, bad reputations will only cause Risk Ratings of events to be raised.
Using risk rating with Global correlation will help the administrator to take into account what really they care of, having the reputation information available with every event gave us two significant benefits: it let us deal with events more quickly, and the change in Risk Ratings let us focus on the events that posed the greatest potential threats.
- SIO Demo
- Platform Requirements
- SIO Demo Script (PDF - 692 KB)
- SIO Demo Training (WebEx - 21:55 min)
- SIO Demo Download
- Cisco Security Intelligence Operations At-A-Glance (PDF - 658 KB)
Public. High-level overview of Cisco's threat security ecosystem that powers Cisco security devices and services.
2009-APR-16, Debbie Daly, Sarah Schultz
- Cisco Security Intelligence Operations Overview Presentation (PPT - 15MB)
Internal. A more in-depth overview of Cisco's threat security ecosystem that powers Cisco security devices and services.
2009-JUL-16, Debbie Daly, Navid Rastegar-Panah
- Cisco Security IntelliShield Alert Manager Overview (PDF - 150 KB)
Customized, up-to-the-minute, actionable intelligence, in-depth vulnerability analysis, and highly reliable threat validation.
- Technical Resources
Practical guidance to help secure business applications and optimize security infrastructures
- Lippis Report: Cisco Launches Cloud Based Global Correlation Threat DefensePublic. Nick Lippis provides an analysis of Cisco SIO and how it powers technology such as Cisco IPS with Global Correlation and Cisco ASA with Botnet Traffic Filters.
2009-Jun-01, Debbie Daly, Sarah Schultz
- Internal Response to Confiker (PDF - 47 KB)
Internal. Overview of the Conficker worm and how Cisco technology can provide defense.
- Cisco 2008 Annual Security Report - (PDF - 4.3 MB)
Public. Cisco threat landscape overview of 2008 and future outlook for 2009.
- Cisco IronPort Virus Outbreak Filters Datasheet (PDF - 412 KB)
- RSA 2009 - Pat Petersons Presentation "Bots and your Business" (PDF) 2009-MAY-15, Cisco IronPort
- Pat Peterson's "HTTP, Web Browsers, and Web 2.0, a Criminal's Dream" (PPT) 2009-MAR-25, IronPort Systems
- Cisco 2009 Midyear Security Report - (PDF - 4.3 MB)
Public. Cisco threat landscape overview of the first half of 2009.
- Cisco Security Intelligence Operations Booklet (PDF - 2.05 MB)
Learn the behind the scenes interworking of Cisco's threat intelligence and response infrastructure.


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Slim Leather Wallet
Regular price $159.00
This is one of the simplest, yet most functional men's wallets on today's market. Its design and construction is built around three key words: breathability, precision, elegance.
We chose the most exquisite leather, added more than 100 years' worth of manufacturing experience and came up with a wallet that will style you up and become your everyday companion for years to come.


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Payment Options
We are very happy to provide a secure Online Bill Pay option for our customers. Please click the button below to register. Feel free to contact us with any questions.
Here are some other payment options:
- We accept cash, check* or credit card payments at our office at 2303 11th Street in Tillamook.
- Payments by phone are credit card only.
- Mail checks* with payment coupon to:
- PO Box 486
Tillamook, OR 97141
(no staples please)
- PO Box 486
*Make checks payable to City Sanitary Service


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7:52am 7/04/07
I woke with the definite feeling I had just done some intensive 'studying' (for lack of a better word) somewhere, and the only recall I had was this task I was given at the end. The task was to find a sentence in this book that best described me, the 'whole me'. (Again, this may be a reference to my beginning blog entry that says I'm on "Journey One – getting to know yourself")
I was sent to a 'waiting room' to look up in a book (one I knew very well) to find a single sentence that I felt would describe who I am. I knew where I wanted to look but it was taking me a long time to find it. I knew the exact sentence I wanted, and it was in this book in a chapter that dealt with 18th century or 1700's. The book covered all kinds of information and had many chapters to go through. I felt had read this book before, and it covered all aspects of myself, from being a mom, to cooking and recipes. I was looking at the titles of the chapters on top, specifically looking for this 18th century reference. Any other sentence I found just wouldn't do a good enough job to fully describe what I felt was 'me'.
My counselor there gave me this task was there off to my left, doing other things while I'm searching the book in this waiting room full of other people. My friend Susan was there talking to people just like a counselor would, participating in the conversation, and trying to help the others with their issues. (Something she does in real life too)
I felt I was holding everything up, causing a delay, in trying to find this sentence. I got the feeling I was there with someone else and I knew I could find a sentence that described that person, but I just couldn't find one to fully describe me.
I did wake with a 'knowing' that perhaps I am NOT able to be described by just one sentence, but am a myriad of all that I have ever been! (which I'm sure may mean my many past lives).
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- Home
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- For The Public
The Wright Center for Graduate Medical Education: Lackawanna FM Wellness Day 2018
On Wednesday, June 27th, 2018, the Wright Center for Graduate Medical Education participated in Lackawanna FM Wellness Day 2018 at the Shawnee Inn and Golf Resort in Shawnee on Delaware, PA. The purpose of the program was to allow us some time outside of work to de-stress and practice wellness. Since we're always getting on our patients to practice self-care, it seemed like a little bit of "practice what you preach" in giving us dedicated time to do some mental, physical, and social activities and take care of ourselves a little bit.
The day started with a guided meditation session to help participants center themselves and de-stress. We learned how meditation can be useful during times of stress or even before going to bed to try and calm a busy mind. The day was gorgeous, so we got to enjoy the beauty of nature with a 3-mile river trip in the Delaware River. Afterward, the group participated in a team-building activity session led by Melissa Philip. Our day concluded with lunch at the Gem and Keystone Restaurant.
Throughout the day, we also discussed the benefits of different kinds of health like making sure you have a physical outlet (regular exercise routine), emotional outlet (having someone outside of the medical field to talk to), spiritual (whatever that might mean to you), etc. Part of the discussion also included acknowledging how participants tend to feel when experiencing stress or well-being imbalance. Many described feeling exhausted, anxious and irritable during these times. It's important to be able to notice when you are starting to feel this way, so you can allot time for taking care of yourself.
There were many of the residents who aim to utilize the meditation practice to assist them in winding down for sleep. Overall, the participants noted they felt low stress levels after the event and had a high level of comfort with their fellow residents after the day's activities. We consider the day a success in helping our residents learn more about their stress and finding healthy ways they can work on their mental, physical, and emotional health.
Tue Sep 22, 2020CMS COVID - 19 Engagement Call - Home Health and Hospice
Category: Affiliate Event
Wed Sep 23, 2020CMS COVID - 19 Engagement Call - Nursing Homes
Category: Affiliate Event
Wed Sep 23, 2020CMS COVID - 19 Engagement Call - Dialysis Organizations
Category: Affiliate Event


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Over the weekend, Justin Bieber hung out with noted doppelganger and Orange Is the New Black star Ruby Rose. The two struck up an unlikely friendship earlier this summer, presumably when they realized they could pass for twins. It's important to have things in common with your pals, and what could spawn a bigger bond than looking like actual spawn?
While fans were freaking out about just how much they look alike (a lot!), we were freaking out how accurately Justin is channeling '90s heartthrobs like Josh Hartnett, Jonathan Taylor Thomas, and, above all, fellow teen pop icon Nick Carter.
Talk about doppelganger. His similarity to the tow-headed Backstreet Boys dreamboat is uncanny.
Reminiscent of a '90s skater shag, Justin's blonde middle-part is likely just the result of being between barber appointments and not an intentional style statement, since he's been covering it up with a hat for the last month straight. But let's hope it'll stick around for awhile. The '90s are experiencing a pretty all-encompassing resurgence, and it sure beats JB's old signature swoop. Now if we could just get him to rock one of those super-fresh ribbed turtlenecks BSB used to wear...


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Company marketing article/blog writing
Budget $12-30 SGD
Hello, we are commercial interior design and build company with more than 10 years experience. We mainly do retail shop, F&B, office, education Institution, smaller formats and pop-up stores and other commercial interior design and build projects. We would like to hire a professional marketing article writer to help us to produce articles.
The articles about(including but not limited to):
1. Company events writing at social media;
2. Industry design trend writing;
3. Retail store business type development direction and design trend writing;
4 Other related marketing or newsletter writing.
31 freelancers are bidding on average $28 for this job
I am a professional content writer, with over 5 years of experience. My skill set comprises of web content writing, product related content, blog or article writing, SEO optimized content, app descriptions, testimonial More
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Writing blogs is something I thoroughly enjoy doing because it has become one of the most relevant writing formats in today's digital world. Whether it's writing informational blogs or promotional content, I craft comp More
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Dear Project Owner, Do you have a Sketch, Image or Dimensions for Floorplan and want to convert it to a detailed blueprint or scaled DWG/ PDF/ JPEG drawing? Or do you want to build your dream house & looking for full t More


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Time keeps marching on and still no news on the Mockingjay Part 2 front. None. At all. If you'd like to hear me and some of our friends at Jabberjays.net be baffled by this, you can listen to the latest Jabbercast, "Age of Ranting." Laugh, cry, get angry, laugh some more. It's therapeutic.
What else? What else?
Well, tonight, Jennifer Lawrence is co-hosting the Met Gala in NYC. ($25,000 a ticket). Here she is in some fabulous Capitol Couture (er- Dior).
Elizabeth Banks was there too, being on-point with the fashion herself. Yay, more pretty pictures!
Yep, that's pretty much it.


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South Sudan and Technology in 2050
When considering South Sudan's prospects for 2050, perhaps the largest unknown is the potential impact of technology on the country's economy, social relations and politics. Technology provides ever-evolving possibilities to transform the economy and the aid sector and to mitigate challenges related to climate change and demographic growth. There is little accurate data on use of technology in South Sudan. As such, this note relies on estimates of technology use and emerging regional and global technological developments, more often posing questions rather than providing specific predictions about the implications of future technology use.
This Better Aid Forum briefing paper on technology and innovation is the first publication of the BAF briefing paper series.
The Conflict Sensitivity Resource Facility's (CSRF) Better Aid Forum (BAF) is a series of events and discussions with different stakeholders to consider the long-term objectives and ambitions of the aid sector in South Sudan. It focuses beyond the timeframes of ongoing political and security dynamics in order to drive collective analysis about the approaches and principles that should underpin international engagement in South Sudan over the longer term.
In June 2019, a two-day event, the Better Aid Forum Experts Meeting, was held in Nairobi to reflect on findings from the Better Aid Forum process thus far, and debate how long-term trends may shape South Sudan's context over the coming decades – and what this means for aid. The CSRF commissioned a number of input briefing papers that consider long-term trends underway in South Sudan, regionally, and globally that are likely to play a role in shaping South Sudan's future.


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GEORGE TOWN, Feb 15 ― Faced with hordes of tourists annually, Penang Hill Corporation (PHC) is working on an overall masterplan that it hopes will better preserve the natural environment of the hills that tower over the island state and is home to diverse flora, fauna and colonial-era buildings.
PHC general manager Datuk Cheok Lay Leng said the masterplan was to ensure the sustainability of the hill resort and its existing infrastructure.
"Our mission is to focus on the preservation and restoration of the hill, what we want to do is to beautify and maintain the hill, not to expand or develop it," he said in a recent interview with Malay Mail.
He said many environmentalists often jump the gun and mistake slope strengthening work for the new buildings when the construction was otherwise.
"We must not forget, Penang Hill was already developed during the colonial era, there were around 52 bungalows built on the hill and we have to maintain the hill, the infrastructure and continuously strengthen the slopes," he said.
Cheok said PHC is open to constructive feedback and encouraged NGOs to step up and assist them in their goals of maintaining the natural beauty of the hill.
He added that care has to be taken with regards to the funicular system that transports visitors and goods up and down the hills, as the rail tracks remain sensitive to the smallest alteration even after upgrades.
"Branches could fall on it or even animals such as monitor lizards run across it and if there is even a slight dent, we have to stop the service to repair it," he explained.
Cheok stressed that such incidents were beyond PHC's control, adding that it could only minimise their occurrences by building fences on both sides of the tracks.
For now, PHC has a few restoration and upgrading projects in the pipeline.
Cheok said some groups often misunderstood PHC's intentions to refurbish and repurpose the heritage bungalows on the hill instead of leaving them vacant and susceptible to damage from the elements.
One of the projects is to restore an impressive Art Deco style bungalow perched on the edge of the hillside, aptly named Edgecliff.
Work to strengthen the hill slopes around the bungalow, believed to have been built around the 1950s, is currently underway. An architect has already been appointed to restore the building.
Edgecliff is to be turned into a gallery and educational centre with a rooftop cafe that will provide its visitors a spectacular 270-degree view of the island state.
"There will be a mini outdoor theatre for events so we can hold talks and small events here," Cheok said.
The visitors centre will not only be a museum on the history of the hill and its funicular train system but will act as an educational centre to spur interest in its diverse flora and fauna.
Another bungalow slotted for restoration is the Woodside Cottage, which is a category II heritage building with a scenic view of George Town city spread out below.
Cheok said PHC is in the midst of strengthening the slope and once done, will call a request for proposal to restore the cottage.
"We want it to be a boutique hotel, the building will be restored, its heritage structure will be maintained and there will not be massive development," he said, adding that there were some land issues that he believes can be resolved soon.
"Our target is to resolve the issues and get the restoration works started by the end of the year," he said.
Another project known as Convalescent Bungalow marked for restoration has also drawn criticism due to the misconception that a 300-room hotel will be built on the grounds, which Cheok debunked.
"We are looking at a small-sized boutique hotel, not a 300-room hotel and we are not changing the structure of the building," he said.
Cheok said that the land on which Convalescent Bungalow stands was not clearly zoned when it was built in 1803 and as such currently, the plot sits on what is now classified as forest reserve land.
Because of the zoning issue, Cheok said restoration works have not started yet and will take "some time" to resolve.
Even the plans to upgrade the old quarters along the Coolie Line, which is also known as Strawberry Valley. It was so named because the colonial British planted the berries there when temperatures averaged 18 degrees Celsius back in the 1800s long before the workers' quarters were built there.
"There are about 12 units of old workers' quarters that are dilapidated and a sore sight, almost like Halloween-themed buildings, other than posing safety issues to anyone who ventured near it," Cheok said.
He said the plan was to put up affordable accommodations such as eco-chalets on the existing footprint of the old quarters.
"There will not be any cutting of slopes, we will be strengthening and stabilising the slopes," he emphasised.
PHC expects to issue a request for proposal for the Coolie Line project sometime this year.


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- Within their long-term partnership, MasterCard and Orange will implement the MasterPass™ digital payments solution within the Orange Romania online platform
- MasterPass™ will allow millions of Orange customers in Romania to make safe and simple payments on the telecom operator's website and mobile app
- Orange is thereby joining the MasterPass™ global acceptance network, that encompasses over a quarter of a million retailers worldwide
BUCHAREST – FEBRUARY 22, 2016 – MasterCard, a leader in digital payments solutions that operates the world's fastest payments processing network, has announced it is expanding MasterPass™ acceptance in Romania, by enabling the digital payments solution for the online platform of Romania's mobile telecom leader, Orange.
The two companies are thereby continuing their long-term partnership, focused on developing and implementing the most innovative and secure technologies, with the integration of one of the most modern and efficient solutions in the digital payments landscape. At the same time, MasterCard and Orange Romania are reaffirming their joint efforts meant to promote electronic payments, as well as to broaden and diversify the array of digital payments available to consumers locally.
The enablement of MasterPass™, scheduled for completion in March this year, will provide consumers with a simplified payment experience through their MasterPass digital wallets; by simply clicking or tapping the "Buy with MasterPass™" checkout option, users will no longer be required to fill their address and card details when making a payment.
"MasterCard is one of the global leaders in terms of driving the movement toward digital payments, with our products and solutions setting the standard when it comes to connecting consumers with the technology of the future. We are delighted to have in Orange a partner that shares our vision: providing consumers with the latest services, extending benefits and improving their payment experience – this is what makes an authentic partnership" said Gabriel Ghiță, Head of New Business Central and Eastern Europe, MasterCard.
MasterPass™ is currently present in 29 countries worldwide and has recorded, in-between March and September 2015, a monthly average increase of 40%, in terms of number of transactions, thereby proving the consumers satisfactions with the product.
"Our customers are increasingly moving towards online payments, which is why we want to meet this trend, by bringing innovation and the technological advances in every step of their interaction with Orange Romania. The digital wallet launched in partnership with MasterCard will provide customers that frequently make online payments with the possibility of one-click payments, a simple and fast payment experience on all connected channels," has stated Julien Ducarroz, Chief Commercial Officer, Orange Romania
MasterPass™ is MasterCard's digital payments solution that simplifies the shopping experience, allowing consumers to pay using their preferred digital wallet, from any device, anywhere MasterPass™ is accepted. The MasterPass™ checkout service provides retailers seeking a growth in their transactions' volumes and speed with a simple method of accepting payments, through digital wallets made from around the world, thus ensuring a simplified, faster and safe payment experience for their busy customers. MasterPass™ provides issuers, partners and retailers with a wide array of digital wallet capabilities – from turnkey specifications to specifically tailored solutions.
About MasterPass™
MasterPass allows shoppers to use a digital wallet where they can store all their payment cards and shipping information in one convenient and secure place. Shoppers can save time and use MasterPass seamlessly across devices anywhere in the world. With shoppers sometimes abandoning purchases when using a mobile device, the simplicity, speed and convenience of MasterPass can help retailers increase their revenues and reduce costs. MasterPass also helps foster loyalty with the retailer, by storing and automatically passing a shopper's loyalty card during checkout.
About MasterCard
MasterCard (NYSE: MA), www.mastercard.com, is a technology company in the global payments industry. We operate the world's fastest payments processing network, connecting consumers, financial institutions, merchants, governments and businesses in more than 210 countries and territories. MasterCard's products and solutions make everyday commerce activities – such as shopping, traveling, running a business and managing finances – easier, more secure and more efficient for everyone. Follow us on Twitter @MasterCardNews, join the discussion on the Beyond the Transaction Blog and subscribe for the latest news.
About Orange Romania
Orange is the market leader in Romania with 10.177 million clients and revenues of € 947 million at 31st of December 2015. Orange Romania is part of Orange group, one of the world's leading telecommunications operators with over 262 million customers on five continents.
Orange Romania offers its clients, both individuals and companies, a complete range of communication solutions, from basic services up to integrated solutions for mobile and fixed voice and data and also TV services. Orange group is a leading provider of global IT and telecommunication services to multinational companies, under the brand Orange Business Services. In March 2015, the Group presented its new strategic plan "Essentials2020" which places customers' needs at the heart of its strategy with the aim of allowing them to benefit fully from the digital universe and the power of its new generation networks.
For more information on the company's products and services, please visit www.orange.ro
Media contact:
Andrada Busuioc, Golin Romania
+40 745 974 785
Click here to subscribe to real-time alerts.


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Meet the Doc Programmers
This moderated session is an open dialogue intended to increase transparency between filmmakers and festivals – demystifying the festival programming process and giving filmmakers an inside look at the people behind the scenes.
This is also an opportunity for filmmakers to share stories and insights about their festival experiences – from submissions to notifications, screenings and more.
Martijn te Pas, IDFA
Shane Smith, Hot Docs
Lauren Cioffi, Sundance
Christine Camdessus, FIPADOC
Pierre Alexis Chevit, Cannes Doc Corner
Kathy Brew, MoMA DocFortnight
Adele Kohout, DokFest Munich
Niklas Engstrøm, CPH:DOX


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Huge product rangeOver 140,000 books & equipment products
Rapid shippingUK & Worldwide
Pay in £, € or U.S.$By card, cheque, transfer, draft
Exceptional customer serviceGet specialist help and advice
What star is that? Where is the Great Bear? A Walk through the Heavens is a beautiful and easy-to-use guide to the constellations of the northern hemisphere. By following the unique simplified maps, readers will be able to easily find and identify the constellations and the stars within them. Ancient myths and legends of the sky are retold, adding to the mystery of the stars. Written for the complete beginner, this practical guide introduces the patterns of the starry skies in a memorable way. No equipment is needed, apart from normal sight and clear skies.
1. Measuring distances in the sky
2. A walk through the heavens
3. Legends of the heavens
4. There's more to see!
Constellations index
"You don't need a telescope to learn where the constellations are – this book tells you exactly how to find them simply by looking at the sky. It's a useful skill to acquire: you can impress your friends when you stumble out of the pub by pointing out what's where in the night sky. The legends are fascinating too. This is a good book for someone who hasn't made their mind up about investing in a telescope."
- The Times
"The third edition of this well-known book is most welcome [...] Wil Tirion's illustrations are a real delight [...] I cannot fault its value and appeal, and would recommend it to any newcomer to the night sky"
- Popular Astronomy


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Even in bad weather there's no excuse not to get your sweat on with this indoor trainer. This magnetic resistance bike trainer converts your bike into an indoor cycling trainer. Just pop your dusty old (or shiny new) road or mountain bike right onto the durable steel frame and you'll be on your way to that perfect summer beach body. Fine-tune to your wheel and tire size with the micro-adjust knob for a custom tuned feel. As you pedal, the internal magnet creates resistance, with 5 levels of resistance. You can change the resistance right from your handle bars.
Shipping adds $5 to this deal.


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Refined sugar-free, oil-free, dairy-free, egg-less, gluten-free
I wanted to make healthy cookies without banana because sometimes I prefer another type of texture and flavor. I could never find a good recipe so I created my own. They even ended up being gluten-free. You can make these with cocoa instead of carob. I found out that I have a mild cocoa intolerance so I used carob instead.
- 90g buckwheat
- 55g millet flakes
- 1tbsp chia seeds
- 2 1/2tbsp water
- 130g dates
- 3tbsp coconut flakes
- 1 1/2tbsp carob
- 1/2tbsp grain coffee
- 1/8tsp vanilla
- 1 pince of salt
- 2tsp almondbutter
- splash of almond milk
- pecans
In a small bowl make a chia egg by adding the chia seeds and the water. Place buckwheat and millet flakes into a blender and mix until it's flouery Then mix all the dry ingredients together. Now mix the dates in a blender until it becomes a paste. Mix all the wet ingredients in another bowl. Now mix all the ingredients together and keep on adding almond milk until it becomes a cookie dough consistency.
I suggest one tbsp of dough for each cookie. Form small balls in your hands and place them on to the backing tray lined with either parchment paper or a backingsheet liner. Top them of with a pecan by gently pressing into the cookie.
Bake the cookies at 160°C for 12-16 minutes
Or 320°F, use convection if you have it.
If you make these cookies feel free to send me pictures on my instagram @createonthegreenside.
Wish all you the best!


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September 2020
Fetal & Women's Imaging 2020 – Advanced OB-GYN Ultrasound
18.75 AMA PRA Category 1 Credits™ 19 Cognate Credits World Class CME is again proud to host the annual Fetal and Women's Imaging conference in Seattle, Washington. We welcome everyone to The Sheraton Grand Seattle for yet another excellent three day course in 2020. Target Audience This course is designed for physicians and sonographers in the fields of gynecologic and obstetric imaging, as well as residents in obstetrics and gynecology, or radiology, and fellows in maternal-fetal medicine. This course may…Find out more »


text: Ramana maharshi as a master. Testimonials of sri aurobindo Sri Aurobindo told that Ramana Maharshi was not fully enlightened as he was dominated by vitalic plane of consciousness, i.e. feelings and desires, so Ramana was evil, self-obsessed, emotional inside. Despite this Maharshi managed to partly enlighten about 40 students, his enlightenment included vitalic plane of consciousness, Ramana was not able to provide full supramental enlightenment to his followers. Maharshi strictly prohibited integral yoga in his sect , partly enlightened sect members had to give a vow to Ramana not to practice integral yoga. In case of breaking their vow, the sect members are raped and astrally castrated by Arunachala Shiva Ramana Maharshi. Moreover Maharshi threatened to castrate or damage testicles of traitors of Arunachala Ramana - integral yogis by astral attacks. Maharshi deeply hated Sri Aurobindo, the Mother, Satprem and all other integral yogis, especially the ones who specialized in divine energy body because they challenged him and wanted him to lose his power over the Earth. Ramana has homosexually harassed integral yogis in mind to humiliate and discourage them from purna yoga. Some integral yogis were raped by Maharshi in astral body on distance and declared "suckers", some were made obsessed with the Devil (Maharshi) or sent to a psychiatric clinic. That is why integral yogis are strongly recommended not to go to Ramanashram -psycho attack is highly likely.


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My little Pipper (Rebecca), Thursday's Child sculpted by Dianna Effner for Boneka, will leave my home this afternoon for a magical place to my eyes, since she's going to Ontario, Canada, to her new mum's home ! How lucky she is !! Going to Ontario !
Pipper will wear a little dress made of gingham (blue and white), designed by Rosemary Ionker (Boneka designer). White knickers, long white socks and blue shoes (from her sister Skye ) will complete her outfit.
She will arrive in her little Boneka preservation bag with her authentication certificate.
Bye bye, Pipper ! You're going to cross the oceans to your new home, in a few hours…
Have a safe trip,
GOOD LUCK, Pipper !


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Mini but mighty. Sturdy, lightweight, and in Bake from Scratch's signature shade of French blue, the GIR (Get It Right) Mini Spatula is an essential item for any baker's tool kit. The flexible, eco-friendly silicon blade and comfortable slender handle are ideal for light mixing, stirring high-heat sauces (up to 464°F/240°C), and scraping up every last bit of your buttercream frosting. Easy to clean and dishwasher safe, this nearly indestructible mini spatula proves that good things come in small packages.
1.4in L x 8.3in W x 0.5in H
Color: French Blue


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ClassFold Down
Length17'1" - 22'1"
This Model is available in:
Calgary, Edmonton, Red Deer, Grande Prairie
Woody's RV World - Quality New Preowned RV's Locations in Calgary, Red Deer, Leduc, Edmonton, Grande Prairie, Abbotsford and Saskatoon. We carry Coachmen, Grand Design, Imagine, Solitude, Reflection, Forest River, Heartland, Puma, Keystone Alpine Avalanche Cougar Outback brands in Tent Trailer, Travel Trailer, Class C, Class B, Class A & Diesel Pusher models.
FLAGSTAFF Hard Side Trailers - The Best of Both Worlds!
CHECK-OUT These Lightweight Trailers - ONLY @ WOODY'S RV WORLD
- Cherry Interior with "Tile-Look" Linoleum
- Two-Tone Fabric Interiors
- Residential Style Kitchen Faucet
- Stainless Steel Look Appliances and Sink
- Double Pan Sink with High Rise Faucet (HS: T19SCHW, T21QBHW Only)
- Electric Water Pump
- Hot Water Package (Incl. Water Filter, Outside
- Shower, Six Gallon DSI Hot Water Heater) (M: 206ST, 207, 208, 227, 228, 228BH, 228D)
- Port-a-Potty (M: 206ST Only C: 425D Only HS: T12RB, T12RBST, T12BH, T12DDST, T12RBTH, T19QBHW, T21QBHW Only)
- Shower Cassette Package Incl. Water Filtration System, Six Gallon DSI Hot Water Heater, Demand Water Pump, and Cassette Toilet
- Antifreeze Inlet to Bypass Fresh Water Tanks When Winterizing
- Permanently Mounted 3-Burner Indoor Range w/ Glass Stove Top Cover
- Three Burner Glass Top Stove with Oven (HS: T19SCHW, T21QBHW Only)
- Microwave
- 3 Way Refer 2.5 cu. ft.
- Extra Large 3 Way Refer (HS: T19SCHW, T19QBHW, T21QBHW Only)
- Free Standing Lite-Ply Table – High Pressure Laminate (Most Models)
- Comfortable Family Style Dinette w/ 4" Cushions
- Residential Style Raised Panel Doors
- Wood Drawers w/ Full Extension Metal Guides
- Large Clothes Bar
- AM/FM Stereo with CD player TV Outlet with Cable and Satellite Hook Up
- 30 Amp Detachable Power Cord w/ Storage Bag
- 35 Amp Converter w/ Built in Battery Charger
- 12V Safety Breaker
- Create-A Breeze Three Speed Fantastic Fan
- 10k BTU Cool Cat Heat Pump
- Interior Floor Lights
- 2 Ceiling LED Lights
- LP Leak/ Carbon Monoxide Detector
- Privacy Curtains
- Quilted Top Innerspring Mattresses
- (HS: T12RB, T12BH, T12RBST Only)
- Quilted Top 60" x 80" Innerspring Mattresses (HS: 19QBHW, T21QBHW Only)
- Thermostatically Controlled Heated Mattresses (HS: T12RB, T12BH , T12RBST, T12RBTH, T19QBHW, T21QBHW Only)
- Independent Torsion Axles
- Easy Lube Axles
- Spare Tire, Cover and Mount
- 13" Radial Tires with Aluminum Wheels
- 15" Mud Rover Radial Tires, Aluminum Wheels (Std. T12RBTH, T12RBSOR Only). With Shocks (Std. M: BR23SC, BR28TSC Only)(Note: Dual Axle Model F: BR28TSC) *
- Electric Brakes
- EZ Reach Storage w/ Sliding Tray on All Front Trunk Models (HS: T19SCHW, T19QBHW, T21QBHW Only)
- 28.5" Front Storage Deck w/ 200 # Weight Capacity (Std. M: 228BH, HS: T12BH Only)
- 57" Front Storage Deck w/ 650 # Wt. Capacity (Std. HS: T12RBTH)
- Toylok Mounting Locking System (M: BR23SC, BR28TSC, 228BH, HW31SCTH, HS: T12BH, T12RBTH)
- Built-in A-Frame Mounting Provision for Equalizer Hitch Bar Installation
- Battery Box and Wiring Kit
- Solar Panel Prep
- Dual 20 lb. LP Bottles with Molded Hard Cover and Automatic LP Regulator
- Diamond Plated Lower Front Cap
- Outdoor Gas Grill w/ Worktable
- Outside Speaker
- Patio Light (LTD: 206LTD Only)
- Courtesy Light on Front (M: 228BH, BR23SC, BR28TSC, HW: HW31SCTH, HS: All Models)
- 110V Exterior Outlet (LTD: 206LTD only)
- Door Step S TP* TP
- Vented Entrance Door Window w/ Screen
- Folding Grab Handle
- Exterior Graphic Design
- Completely Enclosed Living Area
- Fiberglass Vacuum Bonded Roof with Metal Interior Roof
- Gas Strut Lift Assist
- Power Roof Lift Assist (HS: T19SCHW, T19QBHW, 21QBHW Only)
- Large Rear Roof Tinted Sky Light with Shade
- Two Front Roof Tinted Windows with Shades
- Smooth Fiberglass Vacuum Bonded Exterior
- Tinted Vinyl Windows
- Large, Opening Picture Window
- One Piece Undercoated Structure Wood Floor
- Powder Coated Tubular Steel Frame
- (4) E-Z Crank-Down Stabilizer Jacks w/ Sand Pads
- Seamless, High Density Polyethylene Wheel Wells
- Under Floor 20 Gallon Fresh Water Tank
- 2000 lb. Tongue Jack w/ Swivel Wheel
- 7-Way Pigtail Plug


text: Introductory session to Dynamics 365 for finance and operation, PowerPoint slides and pictures February 19, 2018 By alirazazaidi Post Views: 1,385 Yesterday I conduct a free session at Microtechx training institute. Purpose of this session to give overview of Microsoft ERP to students and fresh graduate. Session ppt and pictures are here Introduction to Microsoft ERP Dynamics 365 for finance and operation from Ali Raza Zaidi Related


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Contact Customer Scout for More Traffic
Customer Scout is the SEO Marketing Company that you can count on! While Customer Scout is only one of many online marketing companies, we are the company that focuses on only automotive firms and that has generated consistent, proven results for our many valued clients! We understand how important it is for your car dealership to stand out from the crowd and to also get recognized by your consumers online. Our exclusive automotive marketing services and our focus on improvement can be instrumental in the ability of your dealership to compete in your marketplace going forward. Our team is eager to meet with you soon and to discuss the many ways we can take your online marketing efforts to the next level.
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As a car dealership professional, you may be well aware of the fact that most car buyers today will shop online to research the vehicles and dealerships thoroughly before making a decision. This means that your dealership needs to be highly visible online, and this is one of the key areas that we can help you with. After all, if your customers cannot locate your content online, it does not matter how exceptional the content is. It simply will not be read if it is not visible and easily located. With our award winning automotive SEO services, we can help you boost your rankings and traffic online.
If you are frustrated by a lack of results from online marketing or if you believe that you may be lagging behind the competition, now is the time to contact Customer Scout. Through a consultation, you can learn about the efforts that we can take to improve your marketing efforts and results in the coming year and for years to come.


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Cape Town - Hugo Lloris says he does not plan to finish his career with Tottenham Hotspur and would be open to a future move to the Major League Soccer (MLS).
France international goalkeeper Lloris has racked up over 300 appearances for Tottenham across all competitions since joining from Lyon in 2012 and he still has three years to run on the contract extension he signed back in 2016.
The 32-year-old has no immediate plans to leave the club he has captained since 2015 and it would appear, he is happy to see out the remainder of his contract at the Tottenham Hotspur Stadium.
However, Lloris has also now admitted that it has never been his intention to end his career with Spurs and he is open to a new adventure in the future, with the United States being one destination he could consider.
"I do not think I'm going to finish (my career) at Tottenham," Lloris told France Football.
"I still have a few years ahead of me. In any case, I will do everything to make the most of it. You also have to know when to say stop at the right time, but I'm not against the idea of discovering something new.
"That could be the United States. I do not know, I always had trouble looking in the medium term. I am more focused on the short term."
Lloris did come under criticism at certain points last season following a number of high-profile mistakes, but he has been in decent form so far this term, featuring in all five of Spurs' Premier League matches to date.
The World Cup winner feels Tottenham have come on leaps and bounds since he arrived at the club and he insists he has never considered leaving over the past seven years.
"I never really opened the doors [to the idea of leaving Tottenham] because I felt like I was happy where I was," he added.
"I can tell the difference between the state of the club the day I arrived and today. The club has evolved at an incredible speed."
- TeamTalk Media


text: Trump has employed the services of constitutional law expert Alan Dershowitz. Mark Wilson/Getty Images January 26, 2020 Does impeachment need a crime? Not according to framers of the Constitution Stefanie Lindquist, Arizona State University Trump's backers say he is shielded from removal as no criminal offense took place. But this view may be at odds with the original intent of the impeachment clause.


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« AnteriorContinuar »
The Covenanters' Graves—THE BATTLE OF KilsyTH-Scottish
Army in England — Montrose - Famine - Pestilence, The
SCATTERED throughout the length and breadth of Scotland, by the side of busy roads and streets where the strong tide of our modern life is ever ebbing and flowing, in the midst of waste moors where there is nothing but moss and heather and the scream of the lapwing and the curlew, in lonely and rocky mountain glens where the bleating of sheep and the roar of the river are the only sounds that invade the silence, among the islands that stud our coasts, and close to shores ever lashed by the surge of the Atlantic and Northern Oceans, are to be found sometimes a grey boulder, sometimes a rude cairn, sometimes a simple slab, and sometimes a costly monument, marking the resting-place of some of our Covenanting forefathers who fought and bled and died, that their sons might participate in that religious freedom they now so richly enjoy.
Amongst all the places consecrated in the memory of the devout and pious Scotsman, there is none filled with such a inournful interest as the battle-field of Kilsyth. The reason of this is easily understood, for if the numbers
shed in the battttish historyandrews, cl
that perished in the " killing time" of our history be estimated at 18,000, then not less than one-third of that number perished in the battle of Kilsyth! Not the Bass Rock—that Patmos of Scottish history—not Dunnottar Castle, not Airds Moss nor St. Andrews, cluster memories more strongly suggestive of the sufferings of our ancestors in that troublous time.
To understand the battle aright, it is absolutely necessary to grasp intelligently the political situation, and realise the social conditions of the people. It is to be noted, in the first place, that the Covenanting troops, of which General Baillie was the nominal, but Argyll the real, head, cannot be taken as fairly representing the martial ardour or fighting capability of the national army. At that time the Scottish army, to the number of 20,000 men, had been sent to England to prosecute the war against the King, and in defence of the religion so dear to Scotland. On various occasions the English Government thanked this army for their discipline, their gallantry, and heroic achievements. At that juncture the Royalist cause in Scotland seemed entirely crushed. Montrose, however, taking cognisance of the defenceless state of the country, suddenly appeared in the Highlands, and rallying to his standard a very considerable force, rushed down on the Lowlands, carrying everything before him with the impetuosity of a mountain torrent. The question remains, could Montrose, with all his dash, have won a single victory if the Scottish army had been at home to meet him? The field of Philiphaugh, where David Leslie fell upon him like an avalanche, is a perfectly sufficient reply.
Her army in England, and anticipating no internal disturbance, such was the unprotected state of Scotland at this crisis in her chequered history: We must observe, however, in the second place, that at this period the land was groaning under the double Providential visitation of famine and pestilence. The potato and turnip were yet unknown, artificial grasses were not to be introduced for many years yet to come. Slight patches of wheat were grown in one or two fertile straths. Bere and oats were the chief cereals. The year before, the crops had proved a total failure, and in the Annals of Sir James Balfour, Lord Lyon King-at-Arms, there are repeatedly chronicled the petitions addressed to Parliament by the starving people, praying for bread. They came from such far-separated places as Leith, Argyll, and Inverness. The people eked out a wretched subsistence by feeding on slugs and snails. The famine was sore in the land, but there was a greater ill. The plague everywhere was following hard on its footsteps. The pestilence walked at noon-day, and neither gentle nor simple, soldier nor civilian, was free from its foul touch. Parliament ordered the dead to be buried away from the abodes of the living in barren moors and solitary spots. The fumigation of garments and furniture was resorted to, and an order of men—" smeekers "— appointed for the purpose. When a member of a family was seized, all communication between him and other members ceased. Society was driven, in self-defence, to exercise this most fearful act of excommunication. The patients had to stay in their homes, and no person was permitted to visit them. Parliament thus thought to stamp out the disease, but it was only very partially successful. On the very month when the battle of Kilsyth was fought, the plague had reached its greatest height.
A more pathetic illustration of the severity and remorselessness of the pestilence there could not be than the romantic story of "Bessie Bell and Mary Gray." Thę daughters of two neighbouring lairds near the city of Perth, they were young in years, and all the country round rang with their beauty. The plague having entered the town and neighbourhood, to free themselves from the chance of contamination they retired to a lonely and romantic spot not far from the banks of the Almond, and built themselves a rude bower, where, in seclusion and secrecy, they resolved to stay till the Providential visitation was overpast. Nor can we wonder at their action. They were young and admired, life was sweet to them, and it was but natural they should wish to live. A young gentleman of Perth city was the only one who shared their counsels. He brought food to their hut, and was perplexed which he could regard the more, so highly did he esteem them both. The curious pestilence found the secret bower, and Bessie Bell and Mary Gray perished in their pride. The Parliament, which was then sitting in Perth, refused them sepulture in the public burygrounds, and so they had to be buried where they died. In Scottish literature I know not a more touching story than theirs, nor a more pathetic ballad than that which celebrates it :
"O, Bessie Bell and Mary Gray,
They were twa bonnie lasses ;
And theekit it ower wi' rashes.
" They theekit it ower wi' the rashes green
They theekit it ower wi' heather ;
And slew them baith thegither.
" They thocht to lie in Methven Kirkyard,
Amang their noble kin;
And beek fornent the sun.
" And Bessie Bell and Mary Gray,
They were twa bonnie lasses,
And theekit it ower wi' rashes."
We can well understand the feelings of men called to battle from the midst of such gloomy scenes. There must have been throughout the whole army a diffused sense of oppression, and the spirits of the soldiers must have been possessed as by some dismal foreboding, or close-pressing calamity. The battle of Kilsyth is a favourite theme for partisan writers, but a temperate and impartial mind will attribute the overthrow of the Covenanters neither wholly to the military genius of Montrose nor the incompetency of the Field Committee of Baillie's army, but to other and deeper causes. These men of the Covenant, drawn from scenes of starvation and misery, were no men at this juncture to encounter the clansmen of Athole and Badenoch, of Rannoch and Aberfeldy, who, in the enjoyment of florid health, impiously jeered at the plague-stricken inhabitants of the Lowland towns they had passed in their march.
When Montrose appeared at Kilsyth he had a series, if not of brilliant, at least dashing and spirited, victories on his banners. Having chosen his time well, he won battle after battle. In the September of 1644 he defeated the Covenanters at Tibbermuir. A fortnight later he was equally successful at the Bridge of Dee. Crossing the Argyll mountains, when they were clad with winter snow, he crushed the Campbells at Inverlochy. Afterwards he captured Elgin and ravaged Aberdeenshire and Kincardineshire. On the 3rd May 1645, he won the victory of Auldearn, and a month later he added to it the victory of Alford. Let him now crush Baillie, whose army is encamped against him at


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Indian captain Rohit Sharma became the first male Indian cricketer to play 100 T20I matches and second overall after Shoaib Malik when he stepped foot for the toss in Rajkot for the second T20I match against Bangladesh.
He celebrated the occasion with a brutal inning of 85 runs in just 43 balls, leading India to an 8-wicket win and equaling the series 1-1 with the last T20I to be played in Nagpur on November 10. Amid all this what went unnoticed was the moment when Rohit was given his 100th T20I cap or more importantly, the person who did it.
No "hard feelings" for Rishabh Pant despite costly error in Rajkot, says Yuzvendra Chahal
Rohit was given his T20I cap by Mumbai all-rounder Shivam Dube, who had made his India debut in the first match of the series. That the Indian team management let a youngster like Dube, do the honors, speaks volumes about the environment in the dressing room. Dube had received his cap by coach Ravi Shastri in Delhi.
Rohit took to Twitter to express his gratitude and said he would always cherish each and every opportunity he gets to represent the country. "Be it whichever format, I'm indebted to have this opportunity to do something for the country. I have cherished all these times and will do so forever," Rohit tweeted.


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2002 MG TF in gunmetal grey
Just 60000 miles from new, a superb driving budget sports car.
Purchased from the previous owner after his health suddenly prevented him driving, the car had been sitting for 2 years.
It has just had a new MOT and was fitted with:
- Oil and filters
- Pair of new lower suspension arms
- Front discs and pads (large discs on this model)
- Rear discs and pads
- Timing belt kit
Not perfect but a great fun toy for only £2495
Library photo as an indication.


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Where Have All the Installers Gone?
A recent government survey from the U.S. Department of Labor found that in 2014, motor vehicle electronics equipment installers and repairers were among the fastest-declining occupations in the United States, just behind Locomotive Firers. Now don't panic, because we are not elevator operators just yet. First off, they did lump in repairers. Back in the day, every town had a person who could repair car audio equipment. And the product that couldn't be repaired by the local tech would make its way to United Radio in Syracuse, N.Y., where the masters there could usually repair odds-and-ends products (United Radio is still very much in business and thriving, by the way). As far as installation, the year was 2014 - a year where big-box retailers started to shrink their mobile electronics installation staff, especially after insurance rates skyrocketed after untrained installers started ruining expensive advanced automobiles. The 'do no harm' mantra of a good installer does not ring clear with a twenty-something armed with a borrowed Makita.
Also note that the installers were making the least amount of money on the list, further suggesting that it was the big-box retailers, paying close to minimum wage, were the ones doing the cutting.
So, now for the non-doom-and-gloom viewpoint. Most specialty retailers who are doing it right are thriving. They have added to their product mix to include technologies such as vehicle safety and smartphone integration. Moreover, audio sales in the industry remain stagnant, when everyone thought there was going to be a cliff-faced decline. We keep on truckin' along, and making money while doing it.


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"There's no one in the world except for me!!!" – that should be the new theme song for Disneyland, as that is the attitude of 90% of the people there. If you can't tell, I'm sick of theme parks at this point :). Was a bit tired to write things up last night, so I'm doing it today. At some point, we are heading to California Adventure, for more theme park fun.
Got to Disney a little after it opened, went on the Buzz Lightyear ride (of course, I got the highest score 🙂 ). Got a fastpass for Space Mountain and then went on Pirates. Tried to get into the Blue Bayou, but they were booked up for the day. Have lunch reservations today, so we'll have to jump over to D-Land for lunch.
The highlight of the day was probably when Taylor got picked for Jedi training at one of the shows. Took a video of her battling Darth Vader w/my new point and shoot camera. I'll see if I can figure out a way to get the video posted.
Yet another RV park scam – the city of Anaheim requires the dump hose to be air tight, of course, my adapter that fits in 10,000 different kinds of dump openings doesn't fit in the ones here, so I had to buy yet another adapter at the RV park (first time this trip, on our last big trip we hit this issue way more). I'll be spending part of today putting the adapter on the hose so we can dump.
Start to head north tomorrow. Probably will take 3-4 days getting back, depending on how hard we want to hit the driving.
Also, going to post some pictures, be sure to check out the picture of Taylor petting the cow yesterday.


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SEATTLE, Wash. – September 16, 2019 -- DCI Engineers raised more than $76,000 for local non-profit Childhaven during the firm's 31st annual golf tournament at the Golf Club at Newcastle last month. About 400 attendees from the AEC industries attended the fundraising event which was called "Luau on the Links." A combination of 75 DCI and Childhaven staff volunteered their time to coordinate the festivities.
charitable giving
Social Profiles
© 2020 DCI Engineers.
All Rights Reserved.


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CBC News is reporting a story from Provincial wildlife official. They claim a moose was illegally shot and needed to be euthanized by police in Stephenville, and they're looking for information about the incident.
In a release Friday, the department said the moose was allegedly illegally shot "dangerously close to multiple residences" on Dec. 3.
RCMP and Fish and Wildlife enforcement officers responded to a call of gunshots in the area of Queen Street Extension at the old dump road.
An injured moose had to be euthanized by RCMP officers, and wildlife officials later arrived to retrieve the carcass for examination.
Avalon herd protected
Meanwhile, the wildlife department got a report of a separate incident near St. Shott's that a caribou was illegally shot on or around Nov. 29.
That incident happened near the highway, the release said.
The article was published first on CBC News. Continue reading…


text:
- Angelica Panganiban stunned her followers with her recent photo
- She posted it on her Instagram account and gained a lot of comments from her followers
- Some netizens noticed a big change in her body shape
PAY ATTENTION: Click "See First" under the "Following" tab to see KAMI news on your News Feed
Angelica Panganiban delighted her followers with a new photo of her.
She posted it on her Instagram account and as expected, it earned plenty of comments from netizens.
"No matter what I do, all I think about is you," she wrote.
Some of them noticed some changes in Angge's body. They said the she got thinner than before.
Others were even asking her about what she did to achieve her fit body.
"Paano pumayat? Paturo po please"
"Bat parang pumayat?"
"Ang payat nyo na po.. how to be you po"
"Sobrang payat ni Angelica."
"Ang payat mo dito huhuh eat well stay healthy "
"Laki ng pinayat mo idol ibang iba"
PAY ATTENTION: Using free basics app to access internet for free? Now you can read KAMI news there too. Use the search option to find us. Read KAMI news while saving your data!
In a previous report by KAMI, Angelica Panganiban reacted to Nadine Lustre's remarks about her acting skills.
Angelica starred in the comedy-drama series, 'Play House' with Zanjoe Marudo and Carlo Aquino.
She is also part of the Kapamilya comedy gag show, 'Banana Sundae'.
Enjoyed reading our story? Download KAMI's news app on Google Play now and stay up-to-date with major Filipino news!
Jodi Sta. Maria speaks with HumanMeter about the upcoming romantic drama "Man and Wife" also starring Gabbi Concepcion. Let us take a closer look into the movie shooting process and some details about the collaboration of the two celebrities – on KAMI HumanMeter YouTube channel!


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How is President jovenel running haiti
Jacques - October 1 2018, 8:05 PM
I think he is trying really hard to overcome all that corruption that are exist in this country.
He is willing and determine to help but those who have been corrupted for o many years hard to understand what the future of this will be. So therefore they rather becoming an opposition against him if they all agree to have one vision is to solve haiti problem together sometime there will be disagreement but after that haiti first the people are so humble a natural way only God know we need to change and to do so we need international support.


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- Prawn masala curry is a simple yet delicious recipe . This is quite easy and tasty. The nice thing is that the prawns are not marinated so ,only as long as it takes to make the gravy, so the recipe doesn't take much time at all. The trick is to cook the prawns quickly or they will get rubbery and chewy. If you don't have prawns or shrimp, you can make this with skinless, boneless chicken pieces and it is just as delicious.
Making prawns is very easy but to clean and devein the prawns is a very tedious process.
Cleaning prawns by deveining is a very important step as eating prawns without deveining causes severe health issues.
Make sure to devein them prior to making any prawn recipe.
Prawns are quick in cooking and they take not more than 15 minutes to get cooked and they taste delicious in any form of cooking such as prawns fry or prawns curry.
- Cook 30 mins
- Yield 4 servings
- Ingredients
- 1/2 kg prawns peeled, deveined, and washed
- 8-10 garlic pods
1/2 cup fresh coriander
1/2 green chilies
1 Tomato
cooking oil (vegetable, canola, or sunflower)
1 large onion
A small piece of ginger
1 Tbsp coriander powder
1/2 Tsp Turmeric powder
1 1/2 Tsp red chili powder
1 Tsp garam masala powder
salt to taste
1 Tbsp butter
- Procedure
This prawn masala curry tastes yum with rice.
In a blender, combine Onion, Tomato and coriander powder and grind until it's a smooth paste.Keep aside
Also grind coriander, green chili,ginger and garlic.
In a pan, heat Tsp of cooking oil over medium heat.
Add butter in it.
When the oil and butter, add the prawns and Saute until the prawns begin to turn a pale golden brown color.
Add salt and Saute for 1 minute.
Remove and place in a separate container.
Using the same frying pan add 2 Tbsp oil in it keep medium flame.
Add 1 chopped onion. Saute until the onions begin to turn translucent.
Add the grounded paste of tomato, onion , coriander powder and stir well.
Saute until the oil begins to separate from it, This can take up to 10 minutes.
Then add ginger, garlic, coriander paste, Mix well, and saute for 1 minute.
Add the powdered spices, red chili powder, garam masala, tutmeric and salt to taste. Mix well.
Mix to coat all the prawns well.
Cook for 1 to 2 minutes .
Add water and stir well on high flame.
Allow it to boil, then cover the pan.
Cook for 10 to 12 minutes and turn off the heat.
Let us learn the recipe in written format and also with step by step procedure with the help of a video.
There are some more interesting sea food recipes
There are many more non veg curries


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Main Building
Welfare Building
Building No. 6
Building No. 3
Pharmacy Building
University Library & Learning Center
Community Hall
Kodama Memorial Auditorium
Medical Plant Garden
Building No. 2
Informatics Center
The main facility of this center is to support an information environment of education and research for university members. The center is equipped with 12 Internet servers, 229 computers for practical use and a 100 Mbps LAN for the network system. Staffs and students can use these systems and consult with the center about information environments at any time.
Cooperative Research Center
Iryo Sosei University has been conducting technical support, open lectures, seminars held by the College of Science and Engineering, and collaborative and contract research with local corporations, all contributing to the development of local society and deepening cooperation with local and private organizations. Additionally, we promoted the Ministry of Education, Culture, Sports, Science and Technology's High-tech Research Center Project for five years, from 1999 to 2003. We established the Cooperative Research Center with the purpose of orchestrating our conventional activities in a constructive way to promote cooperation between local industry, academia, government and the citizenry, supporting the latest technologies and rejuvenating our reputation as the top university in Fukushima Prefecture.


text:
Telephone: 207.236.9970
Facsimile: 207.236.9971
Susan Griffin
Katherine Gerrish
Whether you are planning a new construction or renovation
project, engaged in an ongoing project, seeking to reduce your
energy costs, or require specialized consulting services, our
comprehensive suite of services in architecture and
engineering and construction risk
management sets us apart from
traditional architecture and engineering firms.
Over the last thirty years, our founders have
successfully delivered more than 5 million square feet of
projects, totaling over $2 billion – under budget and on
The team at Cordjia is dedicated to providing you with those
same results. We work closely with you to determine your
individual objectives and tailor the most creative,
collaborative, and cost effective approaches in all phases of
your project.
Cordjia Capital Projects Group serves Maine-based companies
spanning many industries, as well as performing projects
throughout New England, the United States, and
Learn More >
Cordjia Capital Projects Group ("Cordjia") was selected by Regional School Unit No. 57 ("RSU No. 57") to provide Owner's Representative services in connection with an Energy Savings Performance Contract at twelve buildings district-wide ("Project").
The Project consists of lighting retrofits, building envelope upgrades, window replacements, refrigeration controls, fire alarm system/life safety system upgrades, HVAC equipment replacements, and boiler/burner replacements..


text:
Realistic Virtual Cables in a 2D Environment Representing a 3D Virtual Reality
A new method for the realistic visualization of virtual cables in a 2D environment, which is representing a 3D virtual reality, is presented in this paper. They are described with two consecutive cubic Bezier curves, whose common point is movable. Experiment was carried out and the optimal proportions for the parameters of the curves were obtained in order to achieve a realistic representation of cables. The suggested method has been developed for and implemented in the Engine for Virtual Electrical Engineering Equipment. The obtained results show that it is easy to manipulate the route of the virtual cables in 2D space and that they look realistic for any position of the control point.
virtual reality; virtual cables; Bezier curve; planes
Full Text:PDF
International Journal of Online and Biomedical Engineering (iJOE) – eISSN: 2626-8493