text:
[India], Apr. 4 (ANI): A report by an independent agency has said that the food provided to the Border Security Force (BSF) personnel is full of macro and micronutrients.
The report has summarized that the data of satisfaction level and food preferences collected from 6526 participants under eight Frontiers with different terrain and the geographical area indicated that 97 percent are satisfied with respect to quantity and quality of food.
The report registered that food was able to provide all macro and micronutrients as per Recommended Dietary Allowance (RDA) of ICMR.
The data from 6526 personnel was collected and focused group discussion (FGD) was made at 37 different Unit mess/Cook houses visited by study group.
In February last year, the Defence Institute of Physiology and Allied Science (DIPAS), Defence Research and Development Organisation (DRDO), Ministry of Defence initiated the study for determining nutrient requirements of BSF personnel and adequacy of their diet under the condition of deployment along with a determination of their food satisfaction level.
The Defense Institute of Physiology and Allied Science (DIPAS) is the nutritional advisory to the Indian Armed Forces in terms of determining calorie nutrient requirements of soldiers deployed under different environment all over the country. This institute also does periodical reviews of ration scales of nutritional adequacy.
DIPAS conducted the study with aim and objectives:-
a) To evaluate nutrient requirements of BSF personnel and adequacy of existing ration scale.
b) Satisfaction level of BSF Personnel with respect to food served in their unit mess and their food preferences.
c) To suggest measures for further improvement of diet plan, if required.
The DIPAS has conducted study following stratified random sampling technique including all ranks and job profile/duties from different Battalions/Units including the Border outposts (BOPs). Data of food preference and satisfaction level was collected from 8 Frontiers (4 each of Western and Eastern Command). (ANI)


text:
In order to cater exact requirement of our clients, we are able to manufacture, supply and export Badminton Rackets. Made of supreme quality raw materials that are supposed to be the best in the market, these products have stylish look and design. These products are equipped with special padding on the handles in order to allow better and tighter grip. Lightweight, these products are easy to swing and serve. Badminton Rackets are available with us in different designs and sizes as per the needs of the clients.
Made Up Of Good Quality Of Material
The Wooden Handel Made Up Of Good Quality Of Willow Wood
Good String Used
A.P.G. SPORTS INDUSTRIES All Rights Reserved.(Terms of Use)
Developed and Managed by Infocom Network Ltd.

subset: commoncrawl


text:
Itineraries for Marina Piccola, Italy honeymoons.
Rachel and Jason
Destination: Capri, Italy
Jason and I would like to thank you so much for being a part of our lives during this special time. Your presence at our wedding is truly the greatest gift we could ask for! We couldn't be more excited to start the next chapter of our lives together.
Since we've already inv...
See the itinerary in this honeymoon registry.
See a list of all cities couples visited for their honeymoon.


text:
How to respond to rude, disrespectful student attitudes - The Cornerstone For Teachers. Au.pinterest. Edutopia. All of us have had major classroom disruptions that try our patience and push our limits.
These incidents can threaten our sense of control and generate fear of looking weak to other students. We fear that other students might do the same thing if we don't take a strong stance. Couple these feelings with the possibility of taking the disruption personally, and we have a recipe for disaster. It's important that we divide our response into two parts: Immediate stabilizationIntervention to resolve these issues Crisis Management. Strategies for Students With Scattered Minds. Imagine a team without a coach guiding players toward working together to execute a winning strategy. Imagine a company without a leader to make sure that employees across departments are equipped and organized to collaborate on continually improving products and increasing sales. Imagine a marching band without a drum major to lead musicians through their complicated maneuvers while staying on beat. The brain's executive function network performs in the same capacity as a coach, CEO, or drum major: directing one's thinking and cognitive abilities toward setting goals and planning to achieve them, establishing priorities, getting and staying organized, and focusing attention on the task at hand.
Now imagine trying to perform those abilities if your brain's executive functioning system wasn't working effectively -- no coach to develop a game plan, no CEO to help you organize your resources for accomplishing your goals, no drum major on which to maintain your learning focus. Edutopia.
With so many classroom research studies published daily, you can be forgiven for missing some.
The techniques below are super-tactical and, for the most part, unsung strategies that you'll be excited to try tomorrow. Just remember two things. First, there are always limitations and nuances in research, so we suggest you click the links and dig deeper into the studies. Five Movement Strategies in the High School Classroom – Kenny C. McKee. Each day more research confirms the link between movement and learning.
Brain researcher David Sousa claims that physical activity increases the amount of oxygen in our blood, and this oxygen is related to enhanced learning and memory. A recent Washington Post article suggests that many student behaviors we associate with ADHD may stem from an overall lack of physical movement — both in and out of school. However, many high school teachers still struggle to integrate movement into the classroom. I know that as a former English teacher, movement found its way into many of my "special" lessons, but it was often a missing ingredient of daily instruction. For example, when students worked on creating commercials integrating persuasive techniques, searched for books in the library, or carried out debates, movement was inevitable.
I've included some strategies that teachers of any content area can use to integrate movement into lessons. 1. 30 Techniques to Quiet a Noisy Class. One day, in front 36 riotous sophomores, I clutched my chest and dropped to my knees like Sergeant Elias at the end of Platoon.
Instantly, dead silence and open mouths replaced classroom Armageddon. Standing up like nothing had happened, I said, "Thanks for your attention -- let's talk about love poems. " I never used that stunt again. 17 Ideas to Help Combat Learned Helplessness. By Sarah Tantillo Recently I've been thinking about the ways in which we either inculcate or prevent learned helplessness in students.
Some teaching practices help strengthen students' self-efficacy, motivation and confidence, while others have the opposite effect. And the irony is that teachers might not even realize they are doing things that create this opposite effect. Here's some useful advice, sharing ways to deter "learned helplessness." Some of what I suggest here is ELA-specific but much of it applies more generally to good classroom practice. 1. 20 Strategies for Motivating Reluctant Learners. Kathy Perez has decades of experience as a classroom educator, with training in special education and teaching English language learners.
She also has a dynamic style. Sitting through her workshop presentation was like being a student in her classroom. The 5 Priorities of Classroom Management. For beginning teachers, or for teachers like myself returning to teaching, the most difficult thing to master is classroom management.
I had to relearn what ten years of hard instruction had taught me: Good classroom management is more than just being strict or authoritarian, and it is more than simply being organized. If I want to have my classroom run smoothly as a well-oiled learning machine, I have to set up a structured learning environment in which certain behaviors are promoted and others are discouraged. I have discovered that there are five components of effective classroom management that establish structures strong enough to entice and motivate student learning: Developing effective working relationships with studentsTraining students on how learning takes place in your classroomProtecting and leveraging timeAnticipating student behaviors in well-written lesson plansEstablishing standards of behavior that promote student learning 1. 2.
AnxietyBC Youth. Restorative Justice: Resources for Schools. Restorative justice empowers students to resolve conflicts on their own and in small groups, and it's a growing practice at schools around the country.
Essentially, the idea is to bring students together in peer-mediated small groups to talk, ask questions, and air their grievances. Behavior Management Software - ClassDojo. Kids & Family. Kids & Family Kids & Family on the Blog Century-Old Museum Hosts Garden State Makers With over 40 maker exhibits, 80 galleries full of art and natural science collections, and a full day of workshops, the Greater Newark Mini Maker Faire was a hit with attendees of all ages.
Read more » By Sandy Roberts, April 8th, 2014 @ 11:48 am Tinkering with Kids – Get in It for the Long Haul Why do we educators do it? By Timor Rising, March 23rd, 2014 @ 8:11 am MAKE Author Talks 3D Printing at New York's Museum of Arts and Design Carla Diana, author of Leo the Maker Prince, is doing a hands-on residency sponsored by Shapeways. By Patrick Di Justo, March 12th, 2014 @ 9:12 am 3D, Video Game-Inspired, Comic Book Board Game. Behavioural Institute for Children & Adolescents.


text:
Did You Know?
Over the last 10+ years the average difference between the best performing sector and worst performing sector has been more than 30% per year. HOWEVER, Year-to-date the difference is ~20%. Stay Tuned, Stay Hedged & Stay Patient! {TJM} Disclosure Please remember that past performance may not be indicative of future results. Different types of investments


text:
Your screen resolution:Category: Minecraft axe coloring pages
Information for Downloading:
Wallpaper Info: Minecraft axe coloring pages - image #35
File type: JPG;
File size: 105.6 kB;
Image size: 1131 x 1600 px;
Source image: www.freelargeimages.com
With this tool, you can convert the image to the most suitable resolution for you.
Warning. All images found in the world network and can be used only with permission of the owner.


text:
Have your allergies gotten worse over the Christmas Holidays? The reason for this may be your Christmas tree. That's right - according to research a live Christmas tree will increase the amount of mold in your home by (5) TIMES!!! In case you are wondering - that's alot!
If your allergies have worsened over the holidays get rid of the tree and have your entire home professional cleaned. Do It Now!
Michael Hull
P.S. Don't forget to ask us about our hypoallergenic cleaning system ResponsibleCare!


text:
All images copyrighted by designer
Photographed homes may have been modified from original design. Construction plans are provided as per renderings.
© copyright by designer1st Floor Plan:
© copyright by designerTerrace Floor Plan:
© copyright by designer2nd Floor Plan:
Stories: 2
Total Living Area: 4072 Sq. Ft.
First Floor: 2042 Sq. Ft.
Second Floor: 2030 Sq. Ft.
Bedrooms: 5
Full Baths: 4
Width: 78 Ft. Depth: 67 Ft.
Garage Size: 3
Foundation: Basement
Kildare Place
Plan Specifications
A conical turret atop concrete pillars and arched windows presents a venerable facade. The entry hall, opening through double doors, is garnished with a sumptuous curved staircase. The living room lies straight ahead, featuring an ornate vaulted ceiling. A guest suite and sunken library on the left each open to a charming loggia, bestowing panoramic views. A stunning solarium to the right of the living room employs skylights to wondrous effect. A circular breakfast nook lies adjacent, diagonal to the comfortable keeping room. The upper level confers dramatics views of the keeping and living rooms, and of the foyer below. The master suite offers a lesson in resplendence; a three-sided fireplace, private sitting room, and angled bath with free-standing, oversized tub.


text:
Croise or Cross-foot Jump
This video clip is from the upcoming 'Ballet for Swimmers' Dual DVD – Modified Exercises for Cross-training! Soon to be released. You can order your copy of the entire set at www.coachingbest.com.
Observe that height, body alignment and the explosive power. Wouldn't that improve Starts and Turns in Swimming?


text:
If Karamo Wasn't On 'Queer Eye' Right Now, Here's What His *Other* Dream Job Would Be
Queer Eye's resident culture expert may one day trade in his Bobby-approved digs for the White House, if his recent comments are any indication. As he said in a new interview with LinkedIn, Queer Eye's Karamo Brown is interested in politics and he's thought about running for office in the future. Honestly, President Karamo Brown does have a nice ring to it.
If he wasn't already the star of one of Netflix's hottest shows, Brown might turn his sights onto another passion of his: politics. That doesn't mean he doesn't love his television career, though. He said, "So, I do love TV. I love it with all my heart and ironically TV was my second dream job." But if there was something else that he could do, he would turn to his other passion. The reality star said during the video interview:
"Going from social services to this… but now that I'm in television and I'm succeeding and it, I think my second dream job that I've always played and toyed with is the idea of politics. I love politics and I've always thought about running for office one day."
Brown certainly has the experience to back up his passion for politics. He went on to say that he's spent time with both Barack Obama's administration and Donald Trump's current administration. He continued, "I've spent time at the U.N. and the more I get into these environments and I learn more and see the power of uniting people though legislation, it excites me."
As he mentioned, Brown is no stranger to the political sphere. In an interview with Parents.com, the culture expert described his past as a social worker and his contributions to different policies under the Obama administration. He explained he had a multitude of jobs over the years, including as a producer for the OWN Show on the Oprah Winfrey Network. The Queer Eye star also served as a social worker for some time, as he was adopting his second son, Chris (who is the half-brother of his older son, Jason). The publication noted that his passion for helping those closest to him translated into a desire to help others as well.
According to Parents.com, Brown helped to create policy and legislation to support LGBT youth and their allies during after school hours under the Obama administration in 2016. More recently, the reality star also visited the current administration, as he spoke about in an interview with the rest of the Queer Eye cast for Vulture. He visited Karen Pence's office, along with a group of actors, in order to discuss access to the arts. "It was phenomenal to be able to go in there and discuss arts, but also to speak about LGBT issues," he said. Brown also explained to The Hollywood Reporter that he had a conversation with her staff, in which they said that she supports the arts, something he said, "gave me a glimmer of hope."
Of course, considering Karen Pence husband's stance on gay marriage and LGBT rights, it was an especially interesting visit for Brown to go on. And the outing had one member of the Fab Five, in particular, side-eyeing him. Jonathan Van Ness joked during his costar's statement, "She's our biggest fan, she watches us every night. Her and Dad like to watch it every night in their modesty outfits, but they watch it completely separated because it's improper to look at each other face to face while you watch gay men."
Based on all of his extensive work and dedication to social issues, it really does seem as though Brown is very much interested in the political world. And considering these new comments, it's possible you could see the Queer Eye star's name on your ballots sometime in the future.


text:
Want some fries? The success story of this businessman will surely make you yearn for so much fries!
Hasif Othman, a 26-year-old entrepreneur from Singapore, was the man behind "Katoshka" who thought of bringing the fries business after graduating from the Royal Melbourne Institute of Technology (RMIT).
According to Hasif, he named his business "Katoshka" which is a Russian term for potato, to have a brand name that sounds 'international'. His fries were inspired by Amsterdam chips which were served in cones and made from premium grade Russet potatoes.
Hasif narrated that he took the risk of putting up his business despite being 'alien' in the food and beverage industry after the idea just popped out while conversing with his bestfriend, Shybree.
From then on, he spent about three to four months planning and conceptualizing his business. He invested RM31,400 (US$7,350) out of his personal pocket and some financial support from his parents as starting capital.
"A lot of R&D was done. We had to decide first what would be on the menu and from there, we sourced for the ingredients. Then we got our family and friends to conduct taste tests on our menu," the Katoshka owner said.
And to make his fries different from his competitors, Hasif revealed that they import their potatoes direct from the US. Prior to serving, they carefully cut them into ideal sizes, fried them not only once but twice to achieve the golden brown appearance, and top them generously with special sauces which made it exceptional.
Just like any other businesses, Hasif shared that they had encountered problems at the start of the business. For the first two months, it also did not generate so much income for him. He said customers back then had suffered long lines and felt bored because of waiting so long for their orders to be served, but eventually got over it as times went by, when they've learned the 'hang' of it.
And because of their unique fries, many consumers recognized their product and even featured it in media.
"We were lucky because we presented a rather unconventional food for a 'pasar malam' which caught the attention of the media. Furthermore, our main highlight was the salted egg yolk sauce, which was highly raved last year, and this earned us considerable attention," Hasif claimed.
Recently, the young businessman is happy to share that his fries stall is making good money. In fact, he has other stalls operating in other locations already. Hasif said each stall sells about 300 cups of fries every day, earning him about US$1,500 each day, depending on the location.
Great news is, Hasif still continues to discover and invent concepts and flavors for his business yearning towards serving more and more of his 'saucy' fries!


text:
My name is Megan Argo, professional astrophysicist and freelance science communicator. I am a lecturer in astronomy at the University of Central Lancashire in Preston (see my teaching page), studying galaxies in the nearby universe with radio telescopes (see my publications list), and give public lectures and schools workshops all over the country (see my events list). Please note that, due to COVID-19, I am only delivering talks via Zoom (or similar) for the moment.
I have worked as a scientist in the UK, Australia and the Netherlands, and been lucky enough to observe with some of the best radio telescopes around the world, in Europe, India, the USA and Australia. My passion for sharing the wonders of the universe with children of all ages has taken me from northern Scotland to outback Western Australia, via rural India, the mountains of Columbia, and cosmopolitan South Africa.
I'm a Fellow and Vice President (A) of the Royal Astronomical Society, serving a second term on the organising committee for IAU Commission C2 Communicating Astronomy with the Public, a member of the Institute of Physics, president of Shropshire Astronomical Society, and an honorary member of Macclesfield Astronomical Society. I'm also a panel member of the ING TAG, and a member of the Office of Astronomy for Development's Task Force 3.


text:
7 Surprising Facts About Baby Boomers
Until this year, Baby Boomers were the nation's biggest age demographic (just recently surpassed by the Millennial generation). Baby Boomers are defined as those born between 1946 and 1964. They may also be known as the generation who swooned over the Beatles, grew up watching television, or were active in social change. Here are some other surprising facts you may not know about this fascinating generation.
- Baby Boomers make up 26% of our population - Statistics from our U.S. Census Bureau show that there are 75.4 million Baby Boomers, the second largest age demographic under Millennials at 83.1 million.
- California is home to more Baby Boomers than any other state - Nearly 9 million Baby Boomers live in California, over Texas' (5.6 million), and New York (5.1 million).
- Baby Boomers are delaying retirement - Research has shown that the generation is delaying retirement due to the desire to stay active. Gone are the days that retirement is dedicated to sitting at home. In fact, many vow to continue to stay busy with future travel or special project plans.
- Four Baby Boomers have been our president - Our four U.S. Presidents include Bill Clinton, George W. Bush,Barack Obama and Donald Trump.
- Almost a third of Baby Boomers have graduated college - According to recent census data, an estimated 28.8% of Baby Boomers have earned a Bachelor's degree or higher.
- Most Baby Boomers are homeowners - It's no surprise since owning a home was an integral part of the American Dream image. Today, nearly 80% of Baby Boomers own the houses they live in. In fact, one in four have more than one property.
- About two-thirds of Baby Boomers are married - A total of 66.5% percent of Baby Boomers are still married, while 11.7% have never been married. Today, 17% of Baby Boomers are divorced.


text:
Buck Forester
check out his photogallery
← back
Bogdan - A&F Salmon Reel Model 200
condition: E - Excellent
reel size: 3-5/8
line weight: 8/9
includes: Custom made Reel Cases Made For Stan Bogdan. I HAVE TWO OF THESE REELS LEFT!!!
description: GREAT PRICE FOR A MODEL 200. Beautiful Stan Bogdan Model 200 Salmon Reel made by Stan in the late 60's not very many of these around. Sold by Abercombie & Fitch in the New York store. Also this reel is stamped on the reel foot A&F 200 M for Multiplier, 1.91:1 retrieve ratio (rounded up to the familiar 2:1) multiplier, and combined with with his peerless cam-driven two-shoe breaking system, is still hailed as the best braking system ever designed.Very nice black and gold finish in "E" condition with honest ware to the rim and drag knob. The reel itself look to have seen little action and very well maintain over the years by the Lewis family and yes tis reel was only fished on the finest of Pinky Gillum's Salmon rod as the became very good friends of the family if you have read any of the Gillum rods sold! Great reel for any collection as these older Bogdan's are getting harder to find in any type of condition. Abercrombie and Fitch colors of the light champagne with black accents. This reel is set up for right hand retreive. These reels are actually in the Smithsonian National Museum of American History. These reels have established their reputation with the likes of Lee Wulff, Ted Williams, Thomas Aquinas Daly, who actually did a watercolor of Stan and his rod and reel in "Stan Bogdan at Charley Valley Rock" (2003), and an oil "Still Life with a 150". No other reels have had such tributes, nor has any other reel designer received the well deserved acclaim that Stan Bogdan has received.
Guy Coheleach also did an oil on linen titled Fish On , again featuring Stan with his legendary reel.
No other reel offers such history, craftsmanship, and sheer joy of ownership than a Bogdan.
You are purchasing a piece of history and legend, not just a reel.You might as well buy the best of the best Bogdan!!!
© 2006 - 2020 West Slope Fly. All rights reserved.


text:
Olivia Jade is reportedly still not talking to her mother, Lori Loughlin, following her parents alleged involvement in the national college admission scam "Operation Varsity Blues," despite earlier reports.
"Lori [Loughlin] felt at this point her daughter would come around and forgive her," a source close to the 54-year-old "Full House" actress shared with Entertainment Tonight on Monday. "They have gone to therapy in hopes things would improve, but it doesn't seem that that's happened. Olivia is still not talking to her mother because she's hurt and feels betrayed." (RELATED: Lori Loughlin's Daughter Bragged About Going To School To Party)
"She [Jade] feels this could have all been avoided had her mother listened to her when she expressed she wasn't interested in going to college," the source added. "The fact she has lost her business deals and can't go out in public without being photographed and scrutinized is a constant reminder of what her mother has done." (RELATED: Report: Felicity Huffman Deletes Post About Being A 'Good Enough' Mom Following College Admission Scam Arrest)
At one point, the insider repeated claims that the "When Calls The Heart" star still doesn't feel she deserves jail time for allegedly paying up $500,000 in bribes to get her daughters Jade and Isabella Giannulli into the University of Southern California (USC) by pretending they were competitive rowing recruits.(RELATED: Lori Loughlin Released After Paying $1 Million Bond)
"Lori's situation has gone from bad to worse," the source shared. "Jail time has always been a possibility, but since more charges were filed her reality [of not serving time] seems grim. While the fact she could serve time never leaves her mind, she strongly believes she doesn't deserve to. She truly feels it was all a misunderstanding."
"Olivia Jade is totally over it and won't listen to anything her parents say now," the sourced added. "She is in no way ready to forgive anything her parents have done. Lori doesn't understand Olivia's reaction. She seems to feel her act was selfless and misunderstood and she wants to prove she had all the best intentions and even that she was, in some way, duped into breaking the law."
View this post on Instagram
Loughlin and her husband, Mossimo Giannulli, have since pleaded not guilty to charges of conspiracy to commit fraud and conspiracy to commit money laundering in the case. (RELATED: REPORT: 7 FBI Agents Arrested Felicity Huffman At Gunpoint)
The insider with knowledge also explained that the actress' friends still hope she will realizes that "what she did was unlawful."
"[Lori's] children and most of her friends aren't entirely convinced this was some kind of a mistake," a source said. "They know she is a loving mother who only wants the best for her kids, but they also know she needs to face that what she did was unlawful and [how it ]has affected not only her children, but also many others. Her friends want her to rethink her plan for the case and admit some sort of guilt. Her closest friends have stuck by her despite her huge mistake."


text:
The Forest School at Wyville has been an ongoing project here since 2014. Operating as part of the Grantham Additional Needs Fellowship (GANF), which comprises of two Ofsted-rated "Outstanding" schools and, in turn, is part of the Community Inclusive Trust, the Forest School is an amazing facility for children who need our support.
GANF caters for over two hundred pupils between the ages of 3 and 19 with moderate to severe learning difficulties and complex needs. Many are on the autistic spectrum, with others having ADHD and varying degrees of developmental delay, and some with Profound and Multiple Learning Difficulties.
Pupils are here five days a week during term time, and GANF now has a fully qualified Forest School Practitioner and Higher Level TA, who manage everything in the woods. All activities have been designed to run alongside the national curriculum on a sensory level, covering Geography, PSHE, RE, Science, English, Art & Design, Design & Technology, Food Tech, Citizenship, PE and Music.
There have been several phases to the development of the Forest School, and the woodland now boasts pathways following a sensory circuit through the trees and wheelchair access wherever possible. There are sensory stations around the circuit with bamboo musical instruments, two fire pits (one accessible to wheelchairs) and a spectacular outdoor classroom positioned right in the centre of the woodland, made from natural materials and taking advantage of all the surrounding wildlife.
The children now benefit from being able to regularly access this wonderful natural space – it makes such a difference to them to be outside in a safe and stimulating environment! The school also have use of the Village Hall which provides toileting facilities and a classroom where the children can be kept warm and dry and complete projects that compliment the outside activities.
Ongoing funding will always be necessary to keep the Forest School flourishing. There are standard running costs alongside one-off purchases (gardening equipment for the children, for example), and there are plans for a constant transformation of both the woodland and the Village Hall to improve the facilities on offer.
The current plan is for a complete renovation of the toilets, making a wet room and improving access. There are still some pupils who cannot use the Forest School, and creating an inclusive toilet facility will go some way to enable all the children can enjoy the pleasures that the school offers. We also hope to replace the existing (and almost unusable) kitchen in the Village Hall – at the moment we are unable to prepare food there, so a new kitchen is long overdue!


text:
DJ Khaled's "I'm The One" feat. Chance the Rapper, Justin Bieber, Quavo, and Lil Wayne is his highest-charting single ever.
Khaled's single "I'm The One" feat. Chance the Rapper, Justin Bieber, Quavo, and Lil Wayne debuted at #1 on the Billboard Hot 100. The song has garnered 84 million YouTube views and 55 million Spotify streams in 10 days. It dethrones Bruno Mars' "That's What I Like," which dethroned Kendrick Lamar's 'HUMBLE." the week before.
"I'm The One" has a similar name to Khaled's previously highest-charting single "I'm On One," which peaked at #10.
Congrats to Khaled!
View this post on Instagram
Fan luv we did it!! I have been blessed to have many #1s BUT THIS IS MY FIRST #1 and MY SON @asahdkhaled FIRST #1 on the @billboard #HOT100 "Debuted #1 on the Billboard Hot 100" !!!!!!! Key 🔑 word Debuted ! These the things that Michael Jackson does !! Team work make a dream work!! #DJKHALED feat @justinbieber @quavohuncho @chancetherapper @liltunechi team work !!!!!! Bless up more team work!!! @wethebestmusic team and my @epicrecords team bless up @scooterbraun @poobear @letmeseeyou team work @scooterbraun JB thank u the love y'all showing me is so amazing I'm so grateful real talk thank u we did it !!!! @laried no word can explain how #GRATEFUL I am to you! @la_reid gave me my first label deal 10 years ago ! Years later he set up his new empire at Epic records and called me and said Khaled I have a home for you and We The Best! Two years ago the music business turned their back on me, and @la_reid called me on his Christmas vacation and said Khaled let's make MORE history and join forces We The Best , EPIC! @la_reid there are no words to explain how grateful I am for you believing in my vision!! Thank you and the WHOLE entire @epicrecords TEAM from Radio, Sales, Marketing, legal etc. @tricerocbklyn you're the best product manager in the music business! Thank you for dealing with me every second of the day!! We did it!! Thank you to all the artist that contributed to making this happen!! I'm very GRATEFUL!! This is just the beginning!! Thank you all my music colleagues out there u know u r.. NOW CHECK THIS OUT 👉🏽 This is VERY rare and a special moment…only 5 other songs debuted #1 over the past two years. This is a VERY BIG DEAL!!! 👆🏾👆🏾👆🏾 This is the first Hip-Hop/Rap debut since Eminem in 2010 with "Not Afraid." Hot 100 #1 debuts since 2015: DJ Khaled – I'm the One (2017) Ed Sheeran – Shape Of You (2017) JT – Can't Stop The Feeling (2016) ZAYN – Pillowtalk (2016) Adele – Hello (2015) Bieber – What Do You Mean (2015) Next up GRATEFUL release date!! Executive Producer by @asahdkhaled!! I have more!! I can show you better than I can tell you!! @wethebestmusic @epicrecords @rocnation MORE CHUNE PON THEY🚷 HEAD TOPS!! Soon come ! FAN LUV WE DID IT!!!
Danny Schwartz of HNHH


text: I'm hoping to see Kirby as an addition for a new character in the future. I see he's rather popular among most people here, and he's a very iconic character for the NES. Thankfully, there is a lot of potential for Kirby's power-ups already featured in SMBC, so he would fit right in without too much customization. Basics Kirby can suck up certain bricks (the breakable ones) one at a time and then launch them as a projectile star. He can suck up "useless" enemies and shoot them as stars as well. Down + Jump allows him to slide. Pressing Jump in in mid air will allow him to inhale and puff up to do a couple "air jumps". In order to keep him balanced he would need some sort of limit to his flight. Pressing attack allows him to suck things up, if he's puffed-up, then he'll shoot out a puff of air. The special button will allow him to drop his current power up. Inhaling two enemies at once will allow him to spit out the "super star shot" (i don't know what it's called). If it is possible as far as SMBCs mechanics are concerned, maybe double tapping a direction could allow him to start dashing in that direction. Power Up System I have a couple different ideas for how Kirby's power up system will work. The main difference is how the Super Mushroom functions (there isn't really a power from the kirby games that we can translate to the Super Mushroom). I. Kirby starts the game with a black and white sprite, he cannot get powered up, he can only suck things up to shoot them as stars or just swallow them to no effect (emulating how he played in the gameboy game). By touching a Mushroom, he gets his colored NES sprite and can now begin collecting power-ups. II. Kirby begins with his NES sprite, but gets the ability to Puff, Fly, Slide, and/or Dash only after touching a mushroom. III. Kirby begins with his NES sprite and all of his maneuvers, the Mushroom doesn't do anything. So the Mushroom is useless?? No, in all cases Kirby will be able to suck up power-up items (Mushroom, Fire Flower, Star Man) and shoot them as a Super Star. In order to power up with the Fire Flower, he will have to swallow it. He can just touch the Starman though (since all he has to do in his own game is touch the Lollipop for invincibility). This gives Fire Flowers a use even if you don't want that specific power-up, or if you already have it. The Ability List By swallowing the following items or enemies, Kirby will get the corresponding power up (only one power up can be used at a time, you have to press Special to let go of your current power up in order to swallow another) Spiny -> Needle Hammer Bro. -> Hammer Podobo -> Fireball Koopa -> Kirby can either spit out a shell or swallow it to gain an ability like Wheelie, except he becomes a pink colored Shell instead of a Wheel and will bounce off walls just like Koopa Shells do. Fire Flower -> Flame Breath While in Water -> spitting out water, direction controlled by d-pad, kirby can also swim Music Select Kirby - (12 Seconds, will it fit?) Enter Pipe to Underground - Overworld - Underground - ??? Coin Heaven - ??? Castle - Underwater - Invincible - Lose a Life - Game Over - Grab the Axe - Save the Princess - Here are some previous thoughts on Kirby that I would like to include: rednukleus: "Honestly I would prefer that Kirby simply play with no powers, like in Kirby's Dreamland. He would already be nearly invincible in Super Mario Bros. with his base inhale & spit ability. Let the mushroom grant a hitpoint and change him from white to pink, and the flower make the stars he spits out get stronger. Alternatively, the flower could behave like the spicy food from Kirby's Dreamland (which is essentially the Fire ability, but hey, I'm brainstorming). Kirby games are already extremely easy. If Super Mario Bros. were a Kirby game it would be far easier than even Kirby's Dreamland. I think the old school Kirby is a much better fit for a game with such simplistic enemies." post Walrus: "I also think it's important that Buzzy Beetles and Spike Tops cannot be inhaled. They exist in Mario as the anti-powerup bad guys, and it's not like there aren't enemies in Kirby that can't be swallowed. Letting Kirby eat them would make Hard and Extreme as easy as Normal, if not easier because of the power-ups these enemies give him!" post Cheese: "Unlimited flying should be fine since anyone that wants to beat a level with anything resembling speed will have to fly as little as possible. Kirby's flying has always been really really slow, so I think most people would quickly realize that trying to fly over every level would be a pain in the ass." post


text:
Washington — Every year, more than one trillion gallons of water go down the drain because of household leaks. Leaks may increase a water bill by as much as 10 percent. Annually, the average American family could be wasting more than 10,000 gallons of water — enough for 270 loads of laundry — due to easy-to-fix leaks. Since 2006 WaterSense has helped consumers save a cumulative 757 billion gallons of water and over $14.2 billion in water and energy bills.
Here's how to reduce water waste:
Check: Look at your water meter, usually located outside your house, before and after a two-hour period of no water use. If the number changed, there is likely a leak, which could be as simple to fix as replacing a worn rubber flapper in the toilet tank.
Twist: Fix dripping pipes, fixtures or hoses by using a wrench to twist and tighten the connections. If needed, pipe tape can help seal shower fixtures or hose connections. Check washers and valves for persistent drips and repair or replace, if necessary. Remind everyone to turn faucets and showers off tightly.
Replace: For old or inefficient fixtures not easily repaired, look for WaterSense labeled models to replace them. WaterSense products are available in a variety of styles and price points at home improvement stores. These money-saving products are high performing and independently certified to use at least 20 percent less water. Look for the WaterSense label on product packaging or the website of your favorite plumbing brand. Many WaterSense partners also offer rebates for WaterSense labeled products.
WaterSense, an EPA partnership program, seeks to protect the future of our nation's water supply by offering people a simple way to use less water with water-efficient products, new homes and services. The program helps consumers make smart water choices that save money and maintain high environmental standards without compromising performance.
What They Said
"Fixing household leaks is not only an important way to conserve water, but it is a simple way that American families can reduce energy use and lower utility bills," said Ken Kopocis, Deputy Assistant Administrator for Water at the U.S. Environmental Protection Agency.
More Information
Visit www.epa.gov/watersense/fixaleak to learn more. The WaterSense Facebook page at www.facebook.com/EPAWatersense also has a map to help you find Fix a Leak Week events in your community.


text:
MUMBAI: Central Railway (CR) wants you to help it serve you better. It has started, on a trial basis for six months, a scheme in which passengers can participate and help the railway management by messaging or e-mailing their feedback.
Feedback and suggestions can be SMSed to 9004411111 or e-mailed to firstname.lastname@example.com.
Officials said it would help them align resources and priorities to customers' need. "We need to know what commuters want and this will reduce the gap between commuters' expectations and our performance," CR chief PRO, S C Mudgerikar, said.


text:
Macon — Turning to a bariatric procedure to help with your weight is a lifetime commitment to your healthy journey. For those considering the procedures, both doctors and patients advise you to do your research and find the surgery that best fits your needs.
Dr. Danny Vaughn has been transforming lives with bariatric procedures for the last six years. He helps patients with their weight with three procedure options: Laparoscopic gastric bypass, Laparoscopic sleeve gastrectomy, and Laparoscopic adjustable gastric band. Vaughn says nearly 60% of the procedures done at his office are Laparoscopic sleeve gastrectomy surgeries.
Dr. Vaughn says despite the transformation at the end, people considering the option of surgery should know that it's not the easy way out. He says the process can take as long as three to six months to get approved for the procedure. Before approval candidates must be evaluated and then complete the necessary work-ups before surgery. Dr. Vaughn says just because you have the operation doesn't mean you'll never have to worry about your weight again. In his office, the surgeon says he's witnessed patients do well after the procedures, as well as those who have not lost as much weight as they preferred. He says those who have the most success are the ones who take the diet and exercise component serious.
"There's really three parts to success with weight loss after surgery," explained Dr. Vaughn. "The surgery is one, diet is one, and exercise is one. If you don't do diet and exercise properly you're not going to have as good results."
He says for those considering surgery there are some things to keep in mind. As with any surgery there are risks, but he says the risks are low. He says eating will never be the same after surgery. Once surgery is complete you'll have to eat smaller portions along with other restrictions.
Contrary to what many people believe, bariatric procedures are not cosmetic surgeries. "There's not a cosmetic component to this," said Vaughn. Along with weight loss, Dr. Vaughn says there are also other positive things to keep in mind. "This is really to change your life and help you to be healthier and add years to your life." Dr. Vaughn says one of the advantages of weight loss surgery is that it can help extend someone's life for 10-15 years significantly improving health related to diabetes, hypertension and other diseases.


text: For some people trikes have always been a "fleeting" escape from super cars and the Air Creation Tanarg seems to be the right option to turn to. It's a standard trike that could be flown to sky soaring limits, but not off the cliff or a danger traffic zone since it certainly isn't economical at a price range of $50,000-$85,000. We don't know if it requires a pilot's license, but considering the scope of this two seater aircraft, it seems almost probable that it should need one. It is built on a strong modular wire-mesh structure and uses a Rotax 912 or 582 silent engine. Pretty cool, Aye?


text:
Ieknows – Rainy Daze Lyrics
[intro: iEKNOWS]
Rainy day
Rainy day
I wrote this song on a rainy day
Let's ride with it
Rainy day
Rainy day
[Verse 1]
These flows are all that I got
10 years of rapping nigga just to hope that I pop
If you been through what I been through then you been through a lot
But I learned from Kobe Bryant keep shooting your shot
(Swish, Look)
Don't put your mind in a box
Rapping ain't the only option when you tryna get hot
Shit I knew a nigga in college who invested in stocks
Then moved on to real estate to by buy half of the block
But first he had to stop chasing hoes
That always want to kick it but ain't got no goals
That only get attention or a mention when they get on Instagram and post pics without no clothes
Something gotta change This shit is kinda strange
It's funny what this generation will do for the fame
She tried to play it smart She gave a little brain
Just to play her part for that Vera Wang
This is just the life we live
So pressure on me just to have a wife and kids
While avoiding all mistakes that my father once did
I see the generational gap I'm building the bridge
For all my young niggas
You gotta study the game don't be a dumb nigga
You out here selling cocaine that can't be fun nigga
Cops pull up on your block you better run nigga
To the sun nigga on these rainy days
Oh these rainy days
When my skies are grey
I might go outside
I might go out and play
I bet you never seen a nigga do it like this
I bet you never seen a nigga do it like this
Are we on ?
Are we on ?
Are we on ?
Are we on ?


text:
Important COVID-19 / York Racecourse Show Advisory
We would like to issue an update in relation to The UK Wedding Event at York Racecourse on Sunday 29th March.
At the current time our big show is set to go ahead despite the ongoing Coronavirus (COVID-19) pandemic. However, the government may put in place restrictions which would force us to postpone.


text:
Highlights / General details
Pisa is one of the most visited cities in Tuscany and it is famous for its Leaning Tower. The beautiful Piazza dei Miracoli is among the most beautiful monumental complexes in the world. The town's most prosperous period was undoubtedly the 12th century and this is witnessed by the urban shape of the old town center with many buildings, squares and alleyways that run along the river Arno, which was for centuries the major communication route. It has always been an estuary town and was already an important naval base in Roman times intensifying trade in the Mediterranean. Pisa is also famous for one of the most prestigious higher learning institutions of Europe: the Scuola Normale Superiore. An authorized city guide will accompany you in the visit of the interior of the Cathedral and the exterior of the Leaning Tower and Monumental Cemetery. At the end of the tour you will also have free time to wonder in the square and take plenty of pictures.
Join the Leaning Tower Tour without queuing at the entrance. A breathtaking view will open in front of you after climbing the 296 steps of the tower, a unique perspective of the city for your photos.
Pick-up on request; Travel by GT coach or minivan with air conditioning; Expert multilingual escort available in English, Spanish, Italian, French, Portuguese, Russian, German; Guided visit of Pisa; Entrance to Pisa Cathedral; Guided Tour of Piazza dei Miracoli in Pisa; Chance to take the iconic picture with the Leaning Tower.
Gratuity; Drop-off €6.00 per person (optional).
Hours of operation
Available Monday, Tuesday, Thursday and Saturday; Departs at 9:15am. Check in closes 15 minutes before departure.
Approximately 4 hours.
Meeting Point: Montecatini, Piazza Italia – Check point Bus, near the train station(check in closes 15 minutes before departure).
Participant restrictions
Pisa Excursion with Leaning Tower is not suitable for children under 8 years old.
Customers must be able to climb and descend stairs.
Guests are required to be at the meeting point 15 minutes before departure time.
Complete information, including local telephone numbers at your destination, will be included on your Confirmation Voucher.
**All information requested must be supplied or booking is subject to automatic cancellation**


text:
When you sell your home in Niceville did you realize you are actually going into business?
If you were running a business, would you choose contractors that charge a higher wage even if you knew one who did superior work and charged less? Would you rather use a big company with large overhead or a company that understands the value of your money and actually cares about how much you keep when the transaction is complete?
Do different real estate brokerages attract a different buyer pool? Do buyers care what real estate company is representing the seller? Do you think a person would buy a specific home because one particular company listed it for sale?
If you answered no to these questions, you have a great grasp of the intricacies of home selling. Home selling is a marketplace, and your home will be competing against other homes to attract a buyer. As a home seller, you are a business person, in the business of selling your home. In order to be competitive, you need to hire a real estate company that will not only help position you in the marketplace at the correct price but also help reduce your cost to sell. That is just good business.
You bought your Niceville home and you invested your time and money in it. You should be the one who profits from your investment as much as possible.
Don't let a real estate agent convince you that you have to pay a higher commission to sell your Niceville home quickly- or for more money. At Uber Realty we've sold hundreds of homes for 4%


text:
Banking is no longer just about making loans and selling investment products, according to GoBank, whose strategy revolves around technology-driven deposit taking. The online bank is among the growing number of pseudo-banks that aim to reduce hidden fees and provide self-service features to its customers. Like the fellow pseudo-bank, Simple, GoBank takes a customer-centric approach that many traditional banks are working to replicate.
GoBank provides online and mobile checking account services in exchange for customer-determined fees each month (ranging from $0 to $9). The bank does not issue loans or savings products, in contrast to traditional banks. Instead, the company relies exclusively on fee income to support its deposit-driven operating model. Technology is at the helm of its business, with an easy-to-use mobile app that displays one's current balance on the login screen and debit cards that sport a customized picture for only $9.
Products and Services
Given its tech-focused value proposition, GoBank has naturally kept pace with industry standards like remote deposit of checks (RDC). Where GoBank differs is in the issuance of checks, which is handled through the mailing checks by the bank after payment details are entered online or through the mobile app. GoBank partnered with Wal-Mart to allow its customers access to over 3,900 stores to deposit cash, which is about all one would expect as deposit of cash continues to die off.
Large ATM networks have served as a marketing line for banks of late as they try to resonate with customers' dissatisfaction of costly ATM fees. GoBank is no different, quick to call attention to its network of 42,000-plus ATMs. In my experience, however, the large-scale network wasn't much of a difference-maker as the nearest in-network ATM for GoBank was just as close to my apartment complex as the nearest Chase ATM (my other bank). The silver lining of this finding is that the scale of a bank's ATM network may not matter unless fees are reimbursed from every ATM, like with Schwab Bank and Ally Bank.
Being limited to checking account services, GoBank offers a feature akin to the common savings account, deemed 'the money vault'. The feature is similar to a savings account in that its purpose is to keep funds away from transactional activity, though depositors don't earn interest on their contributions. Like most other banks, GoBank offers a budgeting and spend management tool that is limited to bank-branded accounts, making the PFM feature useless if a credit card is your primary spending tool.
GoBank is quick to promote its check-mailing service but has not made the use of this feature so intuitive in its app. When attempting to write a check to my brother for concert tickets last month, I was forced to add his information through the bill pay portal. He received the check five business days after I submitted the payment, which is unimpressive turnaround for a bank touting this feature. GoBank's peer-to-peer (P2P) fund transfer feature is hardly a check alternative as eligible recipients must have either a GoBank or PayPal account.
To a banking customer that isn't used to paying many fees outside of the occasional ATM fee, I was hard-pressed to throw more than a dollar GoBank's way each month, even when I still had a positive opinion of the bank. The concept of 'pay us what you think we deserve' comes across as altruistic, but the reality is that GoBank will need to blow customers away with its services to capture substantial income from this type of revenue stream. With the lack of a seamless payments service, I don't see GoBank as worthy of more than a dollar in service fees each month.
GoBank has the right idea in getting away from the traditional banking operating model. However, its services as not as cutting edge as advertised. Consumers that are excited to trying new banking features are likely to be equally as disappointed as I was after discovering the hassle of check issuance and major limitations of its PFM product. It's understandable that every new business needs time to work through the kinks, but in a highly competitive banking environment that's undergoing transformation each day, GoBank cannot afford to waste time.
With no cost to open or close a checking account at most banks, attrition is high, meaning banks must find ways to commit customers through differentiated product offerings. GoBank has certainly incorporated a unique element in its products but must identify ways of making them special (i.e. What can the money vault do that a savings account can't?). Next, GoBank must make its products more reliable, starting with the simple issuance of a check. If the bank fails to take these two steps, they will watch more customers migrate to Moven and Simple, like yours truly.


text: Valenti Vitel is today's Instagram dime of the day! The Russian model flaunts her super hot figure on her page and those assets of hers are to die for. If you are not following the gorgeous model, then you are missing out on a lot of sexiness in your feed. In this article, we are going to show you some of the hottest photos of Valenti Vitel and push you to start following her on Instagram!


text:
Article Text
The type 1 insulin-like growth factor receptor (IGF-IR) sends several signals, some of which are contradictory. When the concentrations of insulin receptor substrate 1 (IRS-1), a major substrate of the IGF-IR, are high, the signal is mitogenic, anti-apoptotic, and can even cause malignant transformation. However, in the absence of IRS-1, the IGF-IR sends a differentiation signal, which leads to granulocytic differentiation in haemopoietic cells. The mitogenic signal of the IGF-IR/IRS-1 combination depends largely, but not exclusively, on the activation of the phosphatidylinositol-3 kinase (PI3K).
- insulin-like growth factor 1 receptor
- differentiation
- insulin receptor substrate 1
- transformation
Statistics from Altmetric.com
The type 1 insulin-like growth factor receptor (IGF-IR), activated by its ligands, controls the proliferation of cells in a variety of ways, namely: (1) It sends a mitogenic signal. (2) It protects cells from a variety of apoptotic injuries. (3) It promotes growth in cell size (a requirement for cell division). (4) It plays a crucial role in the establishment and maintenance of the transformed phenotype. (5) It regulates cell adhesion and cell motility. (6) It can induce terminal differentiation. The IGF-IR is expressed in most cell types, the only known exceptions being hepatocytes and mature B cells. Because the IGF-IR is found ubiquitously, it participates in the growth regulation of many cell types, even though the primary growth factor might be another molecule. These various functions of the IGF-IR have been discussed in recent reviews, to which the reader is referred for detailed references.1–5 In our present communication, we wish to focus on two characteristics of the IGF-IR that are seemingly contradictory; that is, the ability of the receptor to send signals for either malignant transformation or differentiation.
Although the mitogenicity of the IGF-IR has been known for a long time,6 there is also a substantial amount of literature on its ability to send a differentiation signal (reviewed in Baserga and Morrione3). For instance, under certain conditions, myoblasts, osteoblasts, adipocytes, oligodendrocytes, neurones, and haemopoietic cells can be induced to differentiate by IGF-I or IGF-II. The role of the IGF system in differentiation and transformation can be studied in haemopoietic cells. Differentiation of haemopoietic cells occurs only if the cells first undergo one or two rounds of replication.7–9 This is true for instance for the granulocytic colony stimulating factor (G-CSF), as well as for IGF-I mediated differentiation.10 Initially, we will review the role of the IGF-IR in malignant transformation and in differentiation. Because IRS-1 plays a dominant role in directing IGF-IR signalling towards either transformation or differentiation, we will later examine additional, new data on the role of IRS-1 in these two processes.
The IGF-IR and the transformation of cells
The role of the IGF-1R in malignant transformation rests on two fundamental observations. The first one is the singular resistance to transformation of mouse embryo fibroblasts with a targeted disruption of the IGF-IR genes.11 The second observation is that the downregulation of IGF-IR function causes massive apoptosis in tumour cells growing in anchorage independent conditions.2 Mouse embryo fibroblasts with a disruption of the IGF-IR genes,12, 13 called R− cells, have been found to be resistant to transformation by a variety of viral and cellular oncogenes. The list of oncogenes that fail to transform R− cells include the SV40 T antigen and/or an activated Ha-ras oncogene,11, 14 the bovine papillomavirus E5 protein,15 the human papillomavirus E7 protein,16 the Ewing's sarcoma fusion protein,17 an activated c-src,18 and others.5, 19, 20 All the agents that failed to transform R− cells readily transformed mouse embryo fibroblasts with endogenous IGF-IR. Accordingly, re-introduction of an IGF-IR into R− cells promptly renders these cells susceptible to transformation. To date, the only oncogenes known to transform R− cells are v-src18 and a mutant of Gα13.21
This observation is quite remarkable, because mouse embryo fibroblasts—for example, 3T3 cells from several strains of mice—have a very strong tendency to transform spontaneously in culture (reduced growth factor requirements, foci formation in monolayer cultures, and formation of colonies in soft agar). An overexpressed IGF-IR is itself transforming,22–24 but this is of doubtful meaning because almost anything overexpressed in mouse embryo fibroblasts is transforming. In the case of R− cells, our interpretation is that there is a signal originating from the IGF-IR that facilitates and is "quasi-necessary" for transformation by the usual agents (physical, chemical, genetic, etc). For instance, the IGF-IR could downregulate the expression of a tumour suppressor gene. This tumour suppressor gene could be strongly expressed in cells devoid of the IGF-IR, resulting in the suppression of transformation.3
From the time of our original observation that the SV40 T antigen failed to transform R cells11 we hypothesised as a corollary that the downregulation of the IGF-IR in malignant cells ought to reverse the transformed phenotype. In fact, downregulation of IGF-IR function, either by antisense strategies or by dominant negative mutants, causes massive apoptosis of tumour cells in vitro and in vivo. As a consequence of the extensive apoptosis of tumour cells, downregulation of IGF-IR function results in inhibition of tumorigenesis and metastases in experimental animals. The evidence and the references on this topic have been summarised in a recent review by Baserga.5 An interesting feature of IGF-IR targeting is that it has only a modest effect on cells in monolayer cultures. It seems that the IGF-IR is not an absolute requirement for normal growth, as confirmed also by genetic experiments.25 It is, however, a strict requirement for anchorage independent growth.26 Human prostatic tumour cells stably expressing a dominant negative mutant of the IGF-IR are not inhibited when growing in monolayer, but fail to form colonies in soft agar or tumours in mice.27 This differential effect on normal growth (cells in monolayer cultures) and abnormal growth (anchorage independent growth) indicates that targeting of the IGF-IR is a promising candidate for use in cancer chemotherapy.
The IGF-IR in differentiation
As already mentioned, the response of haemopoietic cells to IGF-I can be studied in 32D cells. 32D cells are murine haemopoietic cells of the myeloid lineage, which undergo apoptosis within 24 hours of withdrawal of interleukin 3 (IL-3).7 32D cells have very low levels of IGF-IR and do not express IRS-1 or IRS-2,28, 29 which are among the major substrates of the IGF-IR and the insulin receptor (IR).30 When 32D cells express a human IGF-IR cDNA (32D IGF-IR cells), they survive in the absence of IL-3 and, with the addition of IGF-I, they grow exponentially for about 48 hours.31 After 48 hours, the cells begin to differentiate along the granulocytic pathway, and eventually decrease in number,31 as one would expect from terminally differentiated cells. If 32D IGF-IR cells are stably transfected with IRS-1 cDNA, to generate 32D IGF-IR/IRS1 cells, the cells no longer differentiate,31 grow indefinitely in the absence of IL-3, and form tumours in animals.32 It should be mentioned that 32D cells expressing only the IGF-IR cannot be passaged without IL-3, and neither do they form tumours in animals. 32D cells overexpressing only IRS-1 do not even survive for 24 hours in the absence of IL-3.29, 31, 33 Thus, individually, IRS-1 or the IGF-IR cannot transform 32D cells, or even induce their prolonged survival. However, in combination, they cause malignant transformation of 32D cells.
An intriguing aspect of this model (32D/IGF-IR cells versus 32D/IGF-IR/IRS-1 cells) is that 32D IGF-IR cells are stimulated to proliferate for the first 48 hours, before they differentiate. It means that, in terms of cell proliferation, one could not detect any difference for the first two days between 32D IGF-IR and 32D IGF-IR/IRS-1 cells. Although both cell lines are implementing a proliferative programme, only 32D IGF-IR cells are also initiating a differentiation programme. This was demonstrated by looking at an early marker of differentiation—myeloperoxidase (MPO) mRNA. In 32D IGF-R cells, MPO mRNA is already detectable within 24 hours of changing the cells from IL-3 to IGF-I. No changes in MPO RNA values occur in 32D IGF-IR/IRS1 cells.32 Thus, it seems that the IGF-IR does indeed activate both a proliferative and a differentiation programme, with the differentiation programme eventually prevailing. The expression of IRS-1 extinguishes the differentiation programme, leaving the proliferative programme intact.
Regulation of cell size and the activation of p70S6K
One of the pathways that must be activated by the IGF-IR to send a mitogenic signal is through IRS-1, a substrate of the IGF-IR, which is a potent activator of phosphatidylinositol-3 kinase (PI3K).30, 34 IRS-1 sends a strong mitogenic signal and, when overexpressed, transforms cells.35, 36 The IRS-1–PI3K pathway results in the activation of p70S6K,37 a kinase that plays an important role in cell proliferation.38 The IRS-1-mediated inhibition of cell differentiation in 32D IGF-IR cells involves a sustained activation of p70S6K.32 In fact, an inhibitor of p70S6K activity, rapamycin, causes the differentiation of 32D IGF-IR/IRS-1 cells.32 In addition, ectopic expression of IRS-1 causes an increase in the size of 32D IGF-IR cells.32 This is in agreement with results obtained in drosophila and mice. The homologues of IRS-1,39 Akt and p70S6K,40, 41 regulate the size of drosophila, and disruption of the p70S6K gene in mice results in a small mouse phenotype.42 In turn, the effect of this pathway on cell and animal size might be related to the ability of the activated IGF-IR to regulate, directly or indirectly, the synthesis of ribosomal RNA.43–45
Mechanism(s) of IRS-1 inhibition of differentiation
The crucial role of IRS-1 in inhibiting differentiation and causing malignant transformation has prompted us to investigate the mechanism(s) involved in this remarkable switching of programmes. As a beginning, we have generated several mutants of IRS-1 and have asked which domains of IRS-1 are necessary for the inhibition of differentiation. The results of this inquiry constitute the second part of our communication, which presents new data. Figure 1A shows the IRS-1 mutants that we have used and fig 1B gives their levels of expression. All cell lines were mixed populations obtained by the transduction of 32D IGF-IR cells with a retroviral vector,46 expressing the appropriate construct. The mutants, generated by polymerase chain reaction (PCR) mutagenesis46 included a deletion of the PTB domain (δPTB), a deletion of the Pleckstrin domain (δPH), and point mutants at Y608, Y891, and Y935, single or multiple. Several of these mutant IRS-1 molecules have also been studied in 32D cells by Yenush et al,47 but there are two important differences between their studies and ours. Yenush and colleagues47 used the IR, which, by itself, cannot protect 32D cells from apoptosis,48 even for 24 hours. Furthermore, Yenush and colleagues47 limited their studies to short term events (first 48 hours), whereas our studies focus on long term events, such as transformation and differentiation. Nonetheless, their experiments have been extremely useful in planning our approach.
Figure 2 summarises the results on growth and differentiation of these mixed populations expressing mutant IRS-1 proteins. All these cell lines grew very well in IL-3 and all underwent apoptosis after IL-3 withdrawal, unless supplemented with IGF-I. Figure 2A shows the growth of these cell lines in IGF-I, at four and six days after IL-3 withdrawal. Because all of these cell lines were generated from 32D IGF-IR cells, they all grew in the first 48 hours, then two of the cell lines stopped growing and even decreased in number. The two cell lines are those transfected with an empty retroviral vector (therefore similar to parental 32D IGF-IR cells), or with the δPTB mutant of IRS-1. The growth of the cells with mutations at tyrosines 608 and 935 (binding sites for the p85 subunit of PI3K) was somewhat slower, but they kept growing from days 4–6. Aliquots of these cells were taken at day 4 and re-plated under the same condition for another four days, to test their IL-3 independence. The cell lines that grew in the first six days grew again in the absence of IL-3 for another four days, thus showing that they had acquired IL-3 independence. The empty vector and the δPTB cell lines again failed to grow.
Figure 2C and D shows the extent of differentiation of the same mixed populations under the same conditions. These two panels can be summarised by saying that growth and differentiation are inversely correlated, as one would expect. The less the cells grow, the more they differentiate. These experiments were repeated several times by different operators, with consistent results. They show that the PTB domain of IRS-1 is necessary for the inhibition of differentiation. It can be argued that differentiation in 32D IGF-IR/δPTB cells is somewhat inhibited, when compared with the parental 32D IGF-IR cells. Nonetheless, the extent of differentiation is substantial and clearly above that of cells expressing the wild-type IRS-1 or other mutant IRS-1 molecules.
Activation of p70S6K correlates with growth
As already mentioned, the inhibition of IGF-I mediated differentiation by ectopic expression of IRS-1 correlates with the sustained activation of p70S6K.32 We determined p70S6K activation by using an antibody to phosphorylated threonine 389.32 Figure 3 shows the results of a typical experiment. All the mutant IRS-1 molecules that were active in promoting growth also gave a sustained p70S6K activation, extending to at least 60 minutes after IGF-I stimulation. As already reported, p70S6K activation is reduced in 32D IGF-IR cells (no IRS-1). It is also reduced in 32D IGF-IR cells, expressing the δPTB mutant of IRS-1.
These results confirm and extend the observations of Valentinis et al,31 indicating the ability of IRS-1 to inhibit the IGF-I mediated differentiation of 32D IGF-IR cells. If IRS-1 signalling is disabled by a deletion of the PTB domain,47 differentiation is not inhibited. We did not test all the cell lines for growth in nude mice, but we tested the 32D IGF-IR cells expressing the (active) IRS-1 mutant with mutations at the p85 binding sites. Although these cells grew more slowly in nude mice than did 32D IGF-IR/IRS1 cells, they did form tumours (data not shown). We confirm also that the action of IRS-1 correlates with the sustained activation of p70S6K.32
The picture that is emerging is the dual signalling of the IGF-IR, one signal inducing proliferation, and a simultaneous signal inducing differentiation. In the absence of functional IRS-1, the differentiation signal eventually prevails over the proliferation signal, as happens also with other growth factors that induce the differentiation of haemopoietic or neuronal cells. Expression of IRS-1 (or one of its active mutants) extinguishes the differentiation programme, leaving the proliferative programme intact. There are two additional comments that should be made. The first is that IRS-1 exerts a profound negative influence on differentiation. Cells prone to differentiation often do not express IRS-1, or express very small amounts.49 Furthermore, stimuli that induce differentiation often cause a decrease in IRS-1.50 Conversely, overexpression of IRS-1 consistently decreases the extent of differentiation.31, 32 The second comment concerns the pathways used by the IGF-IR for mitogenesis and survival. It is generally agreed that the main mitogenic/survival pathway depends on the activation of the PI3K pathway.1 However, Peruzzi et al have found that, in the absence of IRS-1, two other pathways, not shared with the IR, originate from the IGF-IR.48 The second pathway originates from Y950 and depends on the activation of the mitogen activate protein kinase (MAPK) pathway, whereas the third pathway originates from serines 1280–3 and requires the mitochondrial translocation of Raf1. Interestingly, Navarro and Baserga51 have found that two of these three pathways are both necessary and sufficient for the mitogenic/survival signal. It does not matter which two pathways are operating, as long as two of them are intact.
The IGF-IR sends contradictory signals to cells.5 It can send a powerful mitogenic and anti-apoptotic signal or it can induce differentiation, which results in growth arrest, differentiation, and cell death. The choice between the two signals seems to depend to a large extent on the availability of substrates. In the absence of IRS-1 (or when concentrations are low), the IGF-IR tends to generate a differentiation signal. When IRS-1 is expressed, the signal is not only mitogenic, but it has the ability to transform cells.32 These contradictions need to be kept in mind if we wish to understand correctly the role of the IGF system in cancer biology.
This work is supported by grant CA 78890 from the National Institutes of Health.
Request Permissions
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center's RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


text:
Asset Tracking Transaction Receipts Feature
Effective and streamlined approach for a seamless Asset Management
Enhanced Traceability
Print Transaction Receipts allows Asset Tracking Solution users to generate e-receipts and print paper receipts in order to summarize or analyze Asset Management transactions such as check out/in, move, or dispose of. Companies and employees receive a physical form of verification in addition to the digital audit trail in the system.
Improved Oversight
Make transaction receipts a part of your asset check out/in or reservation workflow. After processing a new reservation, simply print out the information that matters in a few clicks.
Generate Custom Receipts
Choose what information should go on the receipt before printing or emailing a document. Popular receipt data includes lists with due dates, locations, and transaction numbers, but can also involve items such as barcodes, contract language, and signature lines.


text:
The physician editors of iMedicalApps recently reviewed the medical apps that were released in June. Here are our picks for the best medical apps that physicians and other health providers should consider downloading.
The 12 Best New Medical Apps Released in June
Be sure to check out our other recent best new apps of the month:


text:
Call edition 2012
A new edition of the Prize of the Belgian Development Cooperation has been launched. This call is open until March 31st, 2011. You can read in the regulations whether you comply with the criteria for participation.
This dissertation is a case study of a wool project among poor farmers in the former Transkei in South Africa, and calculates the economic growth multipliers for the local and national economy. In this connection, the theories of growth linkages between different sectors are considered and applied. This is important in the context of rural development strategies and the place of agriculture in these strategies. If one regards agriculture as an engine of economic development, this means that it has a large growth multiplier. This is established and confirmed in this work with reference to income and spending data for a representative sample of households. It is supplemented with qualitative research into the needs and limitations experienced by the local population, and their situation in a capitalist economy. This highly original and neat work updates the now ageing theory of growth linkages, and applies it concretely and sensibly to a rural development project. It is to be hoped that this approach will be taken up, as all economic development is ultimately a matter of growth linkages and growth multipliers. The merit of this work consists in focusing on this point.
report by Prof. E. Tollens, Agricultural technology and economics, Katholieke Universiteit Leuven, Belgium


text:
The September pick for the Radio Bookclub is The Gifted School by Bruce Holsinger. The novel is set in the fictional town of Crystal, Colorado, which is based on Boulder, Colorado. At the heart of the book is the drama within a community of friends and parents as good intentions and high ambitions collide in a pile-up with long-held secrets and lies.
The Gifted School is written from the perspective of four families who've been a part of one another's lives since their kids were born over a decade ago, the story reveals not only the lengths that some adults are willing to go to get ahead, but the effect on the group's children, sibling relationships, marriages, and careers, as simmering resentments come to a boil and long-buried, explosive secrets surface and detonate.
The novel touches on many contemporary issues, including the schools admissions scandal and the impact of race and class privilege on our children's outcomes.
Hear more of the conversation with Bruce Holsinger in our Afterhours edition.Subscribe to our Radio Book Club Series on iTunes to get new editions and web-only content. Also on Spotify and Stitcher.
The Radio Bookclub is a collaboration between KGNU and the Boulder Bookstore. Every month, Arsen Kashkashian, head buyer at the Boulder Bookstore, selects a book to inspire listeners to read along together. The author will then join us in-studio for a discussion that airs the fourth Thursday of every month at 9am.


text:
INTRODUCING ACF BOOTCAMP CLASSES – Starting Aug 26th!
***Boot Camp classes will start the week of August 26th! These classes are FREE for the first week!! Monday Aug 26th – Friday Aug 30th***
Alpine CrossFit Boot Camp
We believe that consistency along with varied high intensity workouts achieve the BEST results for overall fitness. This class is great for anyone who is new to or curious about CrossFit or exercise in general. Each one hour class includes a dynamic warm-up and various mobility exercises to get you ready to work safely and effectively. Bootcamp classes will utilize part of the CrossFit methodology but only with body weight exercises, running, rowing, plyometrics, kettlebells, medicine balls, dumbbells, tires and more! Boot camp will not utilize technical barbell movements such as Olympic Weightlifting or skilled gymnastics as found in our regular CrossFit classes.
You do not need to attend the Foundations program – Get started any time!
Please see our Schedules/Rates page for more details
What to expect from Boot Camp Classes:
- · A FUN, supportive environment
- · Workouts for ALL fitness levels and abilities
- · Workouts that are FUN and TOUGH
- · Positive, motivating and encouraging coaches
- · Accountability of goals
- · Increased strength, endurance, coordination and agility
- · Nutrition counseling – learn how to fuel your body for performance
- · Team building – Come sweat and reach your goals!
You are not paying for a typical gym membership where they don't care if you show up or not! Your coach and fellow Bootcampers will be call you if you "missing"!! Our Bootcamp includes the highest level of certified, professional coaching and experienced programming, in a positive and fun environment for a fraction of the cost of personal training – About $8 a class!
Current Alpine Members are welcome to attend as well. If you would like to join our regular CrossFit classes, then you must go through our Foundations course first.


text:
It's over. Again. Again. The backlog I mean. It's finished. Soul Hackers went down in quick fashion for an SMT game (about 20 hours for the main game) and just as a small hint, when you get a choice between two routes in a certain dungeon and you take the right path instead of the left and you beat that boss, it makes the final boss much easier if you then have all phys repel demons. Just saying.
So...what now then? How do I really have a backlog? Well, as I've said before, I compartmentalize my backlog. More modern games always come first, particularly if I've paid full price for them. So now is as good a time as any to begin really reaching back to stuff I've always wanted to play. And I think I'll start on the Saturn with Albert Odyssey. Originally released for the SNES but never released in the US, it was later ported to the Saturn, where Working Designs was nice enough to finally bring it to western shores. I've always wanted to play it. And now I will! Right after I 100% New Super Mario Bros U, which is kind of a celebratory thing to me.
I also just want to say that Flight of the Parabeetles can go suck the big one. Getting that last star coin is pretty hard.
Looking ahead to the future, I don't have any new releases to pick up until May 21st when RE: Revelations HD comes out, which isn't even a new game to me since I bought it on release for 3DS, but I'm happy to double dip if it means supporting the best RE game since 4 and honestly one of my favorite games in the whole RE series. Beyond that (just beyond) is Donkey Kong Country Returns 3D, which again, I've already played but it's a really fantastic platformer and I love them a lot so again, happy to jump back to the well.
THEN we start getting the new games. Grid 2, Remember Me (I haven't watched more than the original trailer for it, know nothing about it and I'm keeping it that way. I'm literally going in just knowing the basic concept and zero else), Last of Us, Project X-Zone and Game & Wario round out May to June.
And speaking of June, I have a large thing planned. I have vacation from the 8th-19th and I'm going to spend at least two days playing a ton of classic games on my stream. And when I say classic, I don't just mean the big guns that everyone knows. We're talking classics to me. A celebration of games and happy times! Indeed, it will be a 48 hour gaming marathon. As we get closer to that appointed time, I'll go into a bit more detail and possibly get a donation thing going as well, though I don't expect anyone to donate at all haha. But who knows. The only incentive I'm likely to make is if it goes over a certain amount of money ($100?) I'll continue playing past the 48 hour mark. So you could see a 72 hour gaming marathon from one person. Obviously there'll be a few breaks for food/bathroom here and there but I promise they'll be short. It'll be great!
So, what games have you completed? Have any projects that you're focusing on instead? TELL ME.


text:
You know the drill: share what you've been working on, hobby or work related. Don't be shy!
Myself? I didn't like most music players on Windows for a variety of reasons, (there's a few Unix ones I'm fine with, and unsure about Macs) so I wrote my own. It looks like this.
Working on Tulip Charts. Hope to have it ready to release an alpha very soon.
For work, still time-crunchy for the whole week with a side of wtf.
For not-work, I've been adding patches to my JKL thing still, I learned a bit about
awk so that I could compute a tab-separated time-sheet down to the total amount of hours. Surprisingly easy, I wanna learn more about those tools.
I also distro-hopped to Void Linux on my personal laptop and installed Rio as a window manager because I wanna learn more about Plan9 stuffs. THE POWER OF 9P COMPELS ME.
I had a fit of apostasy and moved all my personal data over from OS X to Windows. I will run WSL+NixOS for my POSIXy work requirements and live in Windows from now on. We're also moving on Wednesday, so while I am happy that we're moving from 50/5Mbs DSL to 1000/50Mbs cable, and the new apartment is gorgeous, moving week is always horrible. Sigh.
For work, we got access to Postgres flavored Amazon Aurora so I'm moving some stuff over from Redshift (that didn't really belong in Redshift) so we can take advantage of e.g. constraints! And indices! I've also been on call for the last two weeks, and it's actually been really enlightening, seeing what parts of the system blow up when and how. I wouldn't want to do devops for love nor money, but being siloed as nothing but an SE has been limiting for me in the past.
Three weeks ago I had to prepare a presentation, in the end I decided on doing it in english since that's what most seemed to prefer, to my surprise (previous discussion). It went over well and I am happy with the outcome.
Now I am waiting on my contract for my internship that I need to do before I can start writing my Bachelor's thesis. I am pretty excited about it, but that means that I have to move for about three to six months and that might make it hard to secure a flat or a spot in a shared flat.
On a more personal note, I set up
mu4e together with
mbsync. I do
password management through
gpg and can send mails asynchronously
with the help
So far I really like it. The only thing that I am struggeling with is openvpn and that I have to run the daemon as root, but I already had that problem before, so that's not really a fault of my new setup.
At work - bugs bugs bugs.
For fun, I had started looking at hackerrank and doing some of the algorithms questions there. Sharpen my mind while I'm just fixing stuff at work!
Started reading 'The Apollo Guidance Computer' - very cool book which describes from basic principles of the hardware up on every aspect of the title of the book :) Really interesting read about the difficulties they had building the computer and how they deal with those difficulties.
I'm working on a legacy Perl application (first time in this language, so check that goal off the list, too) for the ca$hflow.
Growing PB&Jealous Club into a nice little side hustle, broaching the subscriber milestones now. Woke up today (on my birthday nonetheless) to discover we'd been featured on the Cratejoy Editor's Pick email list!
SaaS I'm building is starting to come into shape. Have spent two weeks writing documentation and mocking the API, sketching designs and deciding on features to build for a MVP. Next week or so starts code.
Reading: Working Effectively With Legacy Code (lol), Pragmatic Programmer, Clean Code. Listening to: Ready Player One, How To Win Friends and Influence People, The Subtle Art of Not Giving a Fuck, and 1Q84.
It's also pick-and-pack week for PBJ which means manual entrepreneurship. :)
Trying to be a beacon of optimism in an ever pessimistic world. Scary things happening, and a lot of people feel powerless and disenfranchised. Be safe, be aware. You're loved.
I currently working on an Elixir project ; my main goal is to make a proof of concept of an old idea I have and learn the language. I have to say, I really enjoy writing Elixir code! I only have two concerns: the lack of static typing (I mostly write Coq and Haskell code, so that is quite a change for me) and the boilerplate code I have to write (e.g. for GenServer, the API/Server code).
Actually I cannot. I have a strange error when Dialyzer try to build/get the
dialyxir_erlang-19.2.plt ):
Mind pasting it here?
I had a dependency on
jsx through
coveralls and that was causing problems (hopefully fixed in newer releases).
Checking PLT...
[:compiler, :core, :ecs, :elixir, :engine, :foundation, :kernel, :logger,
:stdlib, :uuid]
Finding suitable PLTs
Looking up modules in dialyxir_erlang-19.2_elixir-1.4.0_deps-dev.plt
Looking up modules in dialyxir_erlang-19.2_elixir-1.4.0.plt
Looking up modules in dialyxir_erlang-19.2.plt
Finding applications for dialyxir_erlang-19.2.plt
Finding modules for dialyxir_erlang-19.2.plt
Creating dialyxir_erlang-19.2.plt
** (throw) {:dialyzer_error, [67, 111, 117, 108, 100, 32, 110, 111, 116, 32, 103, 101, 116, 32, 97, 98, 115, 116, 114, 97, 99, 116, 32, 99, 111, 100, 101, 32, 102, 111, 114, 32, 102, 105, 108, 101, 58, 32, '/usr/lib/erlang/lib/erts-8.2/ebin/erlang.beam', 32, 40, 112, 108, 101, 97, 115, 101, 32, 114, ...]}
dialyzer_plt.erl:469: :dialyzer_plt.compute_md5_from_file/1
dialyzer_plt.erl:458: :dialyzer_plt."-compute_md5_from_files/1-lc$^0/1-0-"/1
dialyzer_plt.erl:458: :dialyzer_plt."-compute_md5_from_files/1-lc$^0/1-0-"/1
dialyzer_plt.erl:458: :dialyzer_plt.compute_md5_from_files/1
dialyzer_cl.erl:74: :dialyzer_cl.build_plt/1
dialyzer.erl:167: :dialyzer.run/1
lib/dialyxir/plt.ex:148: Dialyxir.Plt.plt_new/1
lib/dialyxir/plt.ex:120: Dialyxir.Plt.check_beams/4
Also working on a pet project of mine, an Interpreter in Elixir: https://github.com/fabrik42/writing_an_interpreter_in_elixir
I'm still learning the language and hope some people will see it and teach me a trick or two :)
Generating website traffic to drive data for an ML system I'm building. Did you know simulating users is a pain in the ass? Everything is designed for testing UIs. I had to build my own Markov state machine thing and user modelling.
Anyone aware of any good frameworks? Should I release mine when it's done? It's a node.js thing.
I've been putting little bits of time into my stack based scripting language, PISC. Most recently, I've added the ability to use a dictionary as a special lookup for executing words prepended with
@, to make scoped I/O a little more natural, and allow for more easily using a dictionary as a sort of module-like thing.
A small example:
0 :i #Set i to 0
"count.txt" [
# $i puts the value of i on stack
10 [ $i @write-line ++i ] times
] with-output
Try to figure out why saucelabs is so freaking hard to integrate end-to-end tests with on one of my pet projects. Almost every google-able page for "protractor and saucelabs" is a 404'd page on saucelabs own site :/
Not really in the technical realm at all, so perhaps the odd duck out here. I'm working on a pitch for a series of ebooks on serverless topics (queue: "what does serverless even mean" or "FaaS is more accurate").
For school:
If that weren't enough, I'm also working on beefing up my resume for landing a software developer job so I'm learning Spring and Hibernate.
Wrapping up a batch of layout fixes for the Haskell Book, getting hardcover proofs of it this week.
More storefront work for Lore Pub which is now TLS'd and has an A+ Qualys rating. Learned some things about intermediate certs and cert chaining in the process.
Probably more work on a card game with a friend.
Working on a pet project to teach myself Cycle.js as well as the ins and outs of programming in OCaml+BuckleScript. Also using this pet project to explore a new design for threaded conversations.
Writing some documentation for the IoT Espresso machine I worked on last week. Also, trying to finish my school project (an online exam app).
I'm helping a client debug a super weird bug that destroys their entire cluster of erlang servers in about 10 minutes, but only happens when they move their servers to better (i.e. More powerful) machines.
I'm taking a break from scheme to try out common lisp for my needs, and it makes me very sad.
BUT DUDE. Common Lisp really ain't that bad. ASDF seemed like a bear.. but actually was fairly sensible. I disklike the quicklisp method of managing project dependencies, but it's ok! My project can be quicklisp compatible, and I can manage my projects another way.
Really appreciating the work the common lisp community has done in the last 5-ish years when I last poked around.
Adding a new big feature at work, Haskell book, reading lots of history and art history books. Haven't felt like coding (outside of Haskell book) outside of work for weeks.


text:
Time was when a simple signpost would signal your departure from one state and entrance into another. Over time, government tourist bureaus right off highway exits began to spring up, providing new visitors with maps, historical video presentations and samplings of local fruit or confections.
Today, however, in our era of shrinking government resources and travelers' seemingly tighter schedules, citizens of many states are trying new approaches to welcoming visitors and passers-through.
The "Welcome to Georgia" project is just that: a creative approach designed to communicate the rich history, resources, and potential of the State of Georgia. And it will do it beautifully, taking design cues from Georgia's unique styles and forms.
Lorenc+Yoo Design is proud to be a member of the design team for the Welcome to Georgia project. Along with AMEC Environmental & Infrastructure, Inc. and Andrew Crawford Ironworks, Lorenc+Yoo is designing a series of gateway monuments to be placed at the busiest highway entry points into Georgia. Whether coming from Florida, Alabama, Tennessee or South Carolina, visitors will soon see these monumental signs welcoming them into the Peach State.
The Georgia Department of Transportation is funding the project using revenues from blue highway signs sponsored by local restaurants, hotels, gas stations, and other attractions. Speaking to the DOT's magazine 'Milepost,' State Transportation Board Gateway subcommittee chairman Rep. Sam Wellborn said, "I am very excited to see what possibilities are available to improve the appearance of major roadways into Georgia. I want us to make a positive impact on visitors that will leave a lasting impression when people drive across that state line…a wow factor."
Lorenc+Yoo will share details of the in-progress design later this year. Watch this space for a great new way to appreciate Georgia.
Be sure to "like" Lorenc+Yoo Design on Facebook and "follow" us on Twitter!


text:
Center Valley dentists at Castle Dental providing dental implants
Castle Dental offers high-quality, affordable dental implants, dental crowns, veneers, tooth whitening, and more.
CENTER VALLEY, PA, UNITED STATES, February 13, 2020 /EINPresswire.com/ — Castle Dental is offering residents of the Lehigh Valley high-quality dental implants. Dental implants are among the most popular solutions for missing teeth due to their natural appearance and durability. Castle Dental is striving to make this service more affordable and more accessible to residents of Center Valley, Bethlehem, and Allentown.
"Dental implants are reliable, long-lasting, and natural in appearance," explains Dr. Matthew Lang. "They also help restore oral health and prevent jawbone deterioration."
In addition to offering the Lehigh Valley dental implants, Castle Dental also offers dental crowns, veneers, bonding, tooth whitening, and other cosmetic procedures. CEREC crowns, another popular tooth replacement option, can be created in a day using a digital 3D camera and color-matched to a patient's smile.
Hundreds of patients have turned to Castle Dental's Center Valley dentists for their high-quality cosmetic dentistry procedures. General dentistry is also available for all members of the family.
To learn more, request an appointment by visiting http://castledentalcare.com/appointment-request/. New patients are being accepted.
About Castle Dental: Castle Dental is a leading provider of cosmetic dentistry and dental implants in Center Valley, PA. Doctors Matthew Lang and Lucas Mantilla offer patients high-quality, experienced, and comfortable care. Sedation dentistry, dental crowns, and general dentistry are also available. To learn more visit https://www.castledentalcare.com.
Melissa Dugan
Castle Dental
+1 6102822249
email us here
Visit us on social media:
Source: EIN Presswire


text:
Episode 153: Advancements in facial recognition technology
22 December, 2015
category: Biometrics, Financial, Government
Many bold claims were made about facial recognition technology in the wake of the September 11, 2001 terrorist attacks in the U.S. Vendors said facial recognition could spot wanted criminals in a crowd and perhaps stop terrorists from entering the country. The reality was quite different as it turns out that the technology works best with cooperative subjects and good quality images.
Now, the technology is more likely to be used in a one-to-one scenario, like authenticating a user on a mobile device. Financial institutions are also using it for mobile transactions. Brian Martin, director of Research and Technology at MorphoTrust, spoke with Regarding ID's Gina Jordan about changes in facial recognition since 9/11.


text:
Clinic at Saffron Walden Hospital to shut
PUBLISHED: 09:00 22 October 2015
A community clinic has been shut down in Saffron Walden forcing patients to travel to Cambridge for treatment.
And the Ear, Nose and Throat clinic at Saffron Walden Hospital's Radwinter Road site has closed earlier than planned, meaning many patients are receiving last-minute notification or facing cancellation of their appointment.
Changes in the clinician's schedule has meant that the service was to move to Addenbrooke's Hospital on November 5, but workforce constraints have forced Cambridge and Peterborough Clinical Commissioning Group to move the clinic to Cambridge with immediate effect.
Norman Viney, from Victoria Avenue in Saffron Walden, found out about the changes on Friday (October 16) when his 92-year-old mother in law attended her ear appointment.
"She went to the ear clinic in her wheelchair only to be told that the clinic is closing and she will now have to go to Addenbrooke's," he said.
"So all these people now have to go there, try and find somewhere to park – and all this put onto a hospital that's already under pressure because of the amount of people it has to deal with from a large area.
"Plus older people do not want to be at Cambridge all day waiting for transport to take them home."
Although located at Saffron Walden Hospital, which is operated by South Essex Partnership University NHS Foundation Trust (SEPT), the contract for the Ear, Nose and Throat (ENT) clinic is run by Cambridgeshire & Peterborough Clinical Commissioning Group (CCG) – the organisation responsible for planning, organising and purchasing NHS funded healthcare for people living in Cambridgeshire.
Cambridge University Hospitals NHS Foundation Trust, which includes Addenbrooke's Hospital, is one of the CCG's main providers.
Adrian Ient, senior media relations manager at the CCG, said of the Saffron Walden ENT clinic: "We are relocating this clinic to Addenbrooke's due to changes to the clinician's schedule.
"Patients who were booked at Saffron Walden are being contacted by phone to ask if they would like to attend Addenbrooke's.
"Those who were due to be booked at Saffron Walden are also being contacted by phone. We are doing this alongside booking other patients appointments for the whole of ENT."
Both SEPT and the CCG have given reassurances that no other clinics or services at Saffron Walden hospital are to be affected or closed at this time.
If you value what this story gives you, please consider supporting the Saffron Walden Reporter. Click the link in the orange box above for details.


text:
Medal Brite Metal Polish
Medal Brite Metal Polish is another fast acting product similar to Clarity1's Precious Metals. The biggest difference between the two comes from the fact that Medal Brite has slightly less cutting ability and is designed for surfaces that are maintained. Medal Brite is still a high quality aluminum polish but also works very well on other soft metals including brass and even copper. Like it's big brother, Medal Brite also works very well on chrome and stainless steel surfaces as well.


text:
Paulaner is one of the oldest and biggest breweries in Germany. They are not only famous for their Oktoberfest tent but also for tradition, quality and really good beer.
Doing business in a sustainable manner combined with courage and innovation, that is "the heaven of the Bavarians," a Paulaner tradition since 1634.
In order to connect their different locations Paulaner has now launched their own branded app with Staffbase. Learn how they stepped into digitalization, what use cases they have established and what employees think about the app in our newest Vlog. Enjoy!
More internal communications app case studies:
- A Mobile Communications App for the Most Innovative Cattle Feeders in the U.S.
- How T-Systems Cuts Through the Noise with an Employee App
- The Cultural Change at World's Leading Heating And Solar Manufacturers