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IDFC Infra Bonds 2011: IDFC Bonds Issue Lot Size, Open
IDFC Ltd. is a non-banking financial investment company that engages in provision of financial services in sectors such as infrastructure, energy, telecommunication, transportation, commercial and
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PhonePi Sensor Streamer 2.0 APK
- Version: 2.0
- File size: 8.93MB
- Requires: Android 4.1+
- Package Name: com.phonepi
- Developer: Priyankar Kumar
- Updated: May 18, 2017
- Price: Free
- Rate 4.80 stars – based on 20 reviews
We provide PhonePi Sensor Streamer 2.0 APK file for Android 4.1+ and up.
PhonePi Sensor Streamer is a free Tools app.
It's easy to download and install to your mobile phone.
Please be aware that ApkPlz only share the original and free pure apk installer for PhonePi Sensor Streamer 2.0 APK without any modifications.
The average rating is 4.80 out of 5 stars on playstore. If you want to know more about PhonePi Sensor Streamer then you may visit Priyankar Kumar support center for more information
All the apps & games here are for home or personal use only. If any apk download infringes your copyright, please contact us. PhonePi Sensor Streamer is the property and trademark from the developer Priyankar Kumar.
A short Note: A Pro version of this app was released on user request in May 2018. It can be accessed at https://play.google.com/store/apps/details?id=com.phonepiplus&hl=en_US
While both versions are suitable for use, the Pro version lets you choose the data format (CSV or JSON), timestamps each data point and has more robust support for all sensors.
It also streams userId field which is useful in a situation where multiple users stream information to a single server. The userId could then be used as a filter to distinguish between the users allowing you to do fun stuff like track the positions and chart out the movement of the users (for example).
Usage Details for this app: https://github.com/priyankark/PhonePi_SampleServer
(Please download the server from the above link and follow instructions in the README or follow instructions as outlined below)
PhonePi allows you to stream real-time data from sensors on your phone: Accelerometer, Gyroscope, Magnetometer, Orientation, Step Counter, Thermometer, Light Sensor, Proximity Sensor and Geolocation (Subject to availability on your device) to a WebSockets supporting server on your RaspberryPi.
You can choose to build your own server to get the data or clone and use the server at https://github.com/priyankark/PhonePi_SampleServer
Assuming you are using the sample server:
Ensure that your RaspberryPi and phone are on the same network. Note the IP address of your RaspberryPi. Run the server on your Raspi (Steps are in the repository's README.md)
The URL in the app needs to be entered in the format:
Enter update time for the required sensors that is the duration after which the data must be re-read and hit the switch. To disable, simply turn the switch off.
Multiple sensor data can be read at once (subject to the availability of the sensors on your device). This project makes use of WebSockets for the transfer of data. The server writes the data into a txt file but one can modify the server code to do whatever python allows them to :)

subset: commoncrawl


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Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240–9. ©2011 AACR.
Triple-negative breast cancers are a biologically and clinically distinct subtype of breast cancer, defined as tumors that exhibit low or no expression of estrogen receptor (ER), progesterone receptor (PR), and HER2 (1). Women with triple-negative disease account for approximately 15% of all invasive breast cancers and are more likely to be younger, African American, have an earlier age at menarche, higher body mass index during premenopausal years, higher parity, and a lower lifetime duration of breast-feeding (2–4). In addition, triple-negative tumors are typically of higher histologic grade and are associated with more aggressive disease and poorer survival (1, 5, 6). These differences in tumor pathology, nongenetic risk factors, and survival among women with triple-negative disease suggest that the etiology of these tumors may differ from other breast cancer subtypes.
Genome-wide association studies (GWAS) have recently identified common, low-penetrance susceptibility variants that are associated with risk of breast cancer (7–16). Growing evidence suggests substantial heterogeneity by tumor subtype, defined by hormone receptor status, for associations with these single-nucleotide polymorphisms (SNP). In particular, variants in 5p12, FGFR2, 8q24, 1p11.2, 9p21.3, 10q21.2, and 11q13 are associated with the risk of developing ER-positive tumors (9–12, 14, 17, 18) but not ER-negative tumors, whereas variants in 2q35, TOX3, LSP1, MAP3K1, TGFB1, and RAD51L1 are associated with both ER-positive and ER-negative diseases (19). To date, no variants have been specifically associated with ER-negative or triple-negative disease. However, variants at TOX3, 2q35, and 2 distinct signals at 19p13.1 have been associated with breast cancer risk in BRCA1 mutation carriers, who predominantly develop tumors displaying an ER-negative and triple-negative phenotype (15, 20, 21). Thus, additional studies specifically investigating ER-negative and triple-negative disease are necessary to understand genetic susceptibility to these breast cancer subtypes.
Here, we report on the first Triple Negative Breast Cancer Consortium (TNBCC) study of genetic susceptibility to triple-negative breast cancer in which associations between 22 common breast cancer susceptibility loci and risk among 2,980 cases and 4,978 controls were evaluated. This comprehensive study included 21 common variants from all known susceptibility loci identified through currently published breast cancer GWAS (1p11.2, 2q35, 3p24/NEK10, 5p12/MRPS30, MAP3K1, ESR1, 8q24, 9p21.3, 9q31.2, 10p15.1, 10q21.2/ZNF365, 10q22.3/ZMIZ1, FGFR2, LSP1, 11q13, RAD51L1, TOX3, 17q23/COX11, and 19p13.1) and a SNP from CASP8 identified in a candidate-gene study of CASP8 (22, 23). We show that SNPs from 4 of these loci are strongly associated with risk of triple-negative breast cancer.
Materials and Methods
Ethics statement
Study subjects were recruited on protocols approved by the Institutional Review Boards at each participating institution, and all subjects provided written informed consent.
Study populations
Samples from several triple-negative breast cancer case–control series, including 2,778 triple-negative breast cancer cases and 1,406 unaffected controls, were genotyped on the iPLEX platform. These subjects were ascertained by 22 studies in 9 different countries as follows: United States, Australia, Great Britain, Finland, Germany, Netherlands, Greece, Ireland, and Sweden. These included cases from the KBCP and POSH cohort studies, cases and controls from the MCCS cohort study, and cases and controls from established population-based breast cancer case–control studies (BBCS, GENICA, MARIE, and SEARCH), hospital or clinic-based case–control studies (ABCS, BIGGS, LMBC, MCBCS, OBCS, SBCS, and RPCI), case-only studies with geographically matched controls (BBCC, KARBAC, SKKDKFZS, and FCCC), and unselected cases identified in tumor collections (DFCI, ABCTB, and DEMOKRITOS). Data from an ongoing GWAS of triple-negative breast cancer, including cases and controls from several of the studies described earlier, and the triple-negative cases from the HEBCS GWAS along with population control data (n = 273) were also included (24). In addition, data from 4 publicly available control GWAS data sets [Wellcome Trust Case Control Consortium UK 1958 birth cohort (WTCCC), National Cancer Institute's Cancer Genetic Markers of Susceptibility (CGEMS) project, Cooperative Health Research in the Region of Augsburg (KORA) study, and the Australian Twin Cohort study from the Queensland Institute of Medical Research (QIMR); n = 3,593] were used. Age distributions and years of diagnosis for individual study sites are provided in Supplementary Table S1, and these studies are described in more detail in Supplementary Material.
Pathology and tumor markers
A triple-negative breast cancer case was defined as an individual with an ER-negative, PR-negative, and HER2-negative [0 or 1 by immunohistochemical staining (IHC)] breast cancer diagnosed after age 18. Criteria used for defining ER, PR, and HER2 status varied by study. These are described in detail in Supplementary Table S2. IHC data for cytokeratin 5/6 and epidermal growth factor receptor for identification of basal tumors were not available.
The following 22 SNPs were genotyped on the iPLEX platform: rs11249433 (1p11.2), rs13387042 (2q35), rs4973768 (3p24), rs10941679 (5p12), rs889312 (MAP3K1), rs2046210 (ESR1), rs12662670 (ESR1, surrogate for rs9397435), rs13281615 (8q24), rs1011970 (9p21.3), rs865686 (9q31.2), rs2380205 (10p15.1), rs10509168 (10q21.2, surrogate for rs10995190), rs704010 (10q22.3), rs2981582 (FGFR2), rs3817198 (LSP1), rs614367 (11q13), rs999737 (RAD51L1), rs3803662 (TOX3), rs6504950 (17q23), rs8170 (19p13.1), rs8100241 (19p13.1), and rs17468277 (tagSNP for CASP8 D302H). For 10q21.2, rs10509168 was genotyped as a surrogate for rs10995190 (14).
Genotype data for 22 SNPs were generated for 2,778 cases and 1,406 controls using a single multiplex on the iPLEX MassARRAY platform (Sequenom). Samples were plated by study as random mixtures of cases and controls with no-template and CEPH controls in every plate. Genotyping quality for SNPs and samples was evaluated by an iterative quality control process. SNPs and samples were excluded on the basis of the following criteria: an SNP call rate less than 95%, Hardy–Weinberg equilibrium (HWE) P < 0.01 among controls, and sample call rate of less than 95%. The final data set of 2,707 cases and 1,385 controls exhibited SNP call rates of more than 99%, HWE P > 0.01, and sample call rates of more than 95%.
In addition, genotype data from cases and controls included in a triple-negative GWAS were available to supplement the iPLEX genotypes. Cases from 10 study sites (ABCTB, BBCC, DFCI, FCCC, GENICA, MARIE, MCBCS, MCCS, POSH, and SBCS) were genotyped using the Illumina 660-Quad SNP array. A subset of MARIE cases were genotyped using the Illumina CNV370 SNP array. HEBCS cases and controls were genotyped using the Illumina 550-Duo SNP array. GWAS data for public controls were generated using the following arrays: Illumina 660-Quad (QIMR), Illumina 550K (v1; CGEMS), Illumina 550K (KORA), and Illumina 1.2M (WTCCC). For HEBCS, population allele and genotype frequencies on 221 healthy population controls genotyped on Illumina HumanHap 370CNV in the NordicDB, a Nordic pool and portal for genome-wide control data, were obtained from the Finnish Genome Center (25). These GWAS data were independently evaluated by an iterative quality control process with the following exclusion criteria: minor allele frequency less than 0.01, call rate of less than 95%, HWE P < 1 × 10−7 among controls, and sample call rate of more than 98%. When DNA was available (n = 1,402), we re-genotyped samples from the triple-negative GWAS as part of the iPLEX study in an effort to obtain as much data as possible from a single platform. Therefore, following preferential selection of data from the iPLEX study, genotypes for an additional 273 cases and 3,593 controls were included from the GWAS data (Table 1). No GWAS genotype data were available for rs10941679 (5p12), rs2046210 (ESR1), and rs6504950 (17q23), and only partial data were available for 5 other SNPs because of the absence of these SNPs from some or all of the GWAS genotyping platforms (Table 1). As a further measure of genotype quality, genotype concordance was evaluated for the 1,402 samples included in both the iPLEX and GWAS. Eighteen of 19 SNPs had concordance rates of more than 98% and rs8100241 showed concordance of 96.3%.
Statistical methods
Allele frequencies for each of the 22 SNPs included in these analyses were estimated using the iPLEX genotype data and the combined GWAS and iPLEX data for cases, controls, and all subjects (Supplementary Table S3). Associations for triple-negative breast cancer were estimated using unconditional logistic regression adjusted for country of residence. The sites were categorized by country of origin (American, Australian, British, Finnish, German, Greek, Irish, and Swedish; Table 1). SNPs were coded for a gene–dose effect by assigning a 3-level (0, 1, and 2) variable to each genotype (log-additive model). We calculated P values, ORs, and 95% CIs from these logistic regressions. Pairwise interactions were tested by including multiplicative interaction terms in logistic regression models. Homogeneity of ORs by country was tested using the Q-statistic (26), and the extent of heterogeneity was estimated by the I2 statistic (27). All analyses were conducted using SAS version 9.2, R version 2.11.0, or Plink version 1.07.
We evaluated 22 breast cancer susceptibility SNPs identified in breast cancer GWAS for associations with triple-negative disease using genotype data from an iPLEX study of the 22 SNPs supplemented with data from a triple-negative GWAS. The combined data resulted in a case–control study of 2,980 cases and 4,978 controls from 25 studies in 8 countries (Table 1). All 22 SNPs were in HWE among controls at P > 0.01. Only rs17468277, rs13387042, rs10941679, and rs614367 showed evidence of heterogeneity by country (rs17468277: P = 0.065, I2 = 47.4%; rs13387042: P = 0.037, I2 = 53.1%; rs10941679: P = 0.063, I2 = 47.8%; rs614367: 0.054, I2 = 49.4%). Of the 22 SNPs from 20 loci, 7 were significantly associated with risk of triple-negative breast cancer (P < 0.05; Table 2). Six SNPs from 4 loci, rs2046210 (P = 4.38 × 10−7), rs12662670 (P = 1.13 × 10−4), rs999737 (P = 2.96 × 10−4), rs3803662 (P = 3.66 × 10−5), rs8170 (P = 2.25 × 10−8), and rs8100241 (P = 8.66 × 10−7), remained significant after correction for multiple testing (P < 2.27 × 10−3). Adjustment for age did not change the magnitude or significance of our results. In addition, we did not find evidence of significant interactions with age for any of the 22 SNPs.
rs2046210, located upstream of ESR1 on chromosome 6q25.1, exhibited a strong association with triple-negative disease (OR = 1.29, 95% CI = 1.17–1.42; P = 4.38 × 10−7; Fig. 1A), whereas rs12662670, located further upstream of ESR1, displayed a similar effect but slightly less significant association with triple-negative disease (OR = 1.33, 95% CI = 1.15–1.53; P = 1.13 × 10−4; Fig. 1B). To assess the independence of these 2 ESR1 SNPs, which are not correlated in HapMap subjects of European ancestry (r2 = 0.09), we included both SNPs in a multivariate model. rs2046210 was more strongly associated with triple-negative risk than rs12662670 (rs2046210: OR = 1.24, 95% CI = 1.12–1.38; P = 5.64 × 10−5; rs12662670: OR = 1.20, 95% CI = 1.00–1.44; P = 0.053) in this model, suggesting that rs2046210 may account in part for these 2 associations. In addition, 2 SNPs at 19p13.1, shown to have genome-wide significant associations with breast cancer in BRCA1 mutation carriers, were highly significantly associated with triple-negative breast cancer (rs8170: OR = 1.27, 95% CI = 1.17–1.38; P = 2.25 × 10−8; rs8100241: OR = 0.84, 95% CI = 0.78–0.90; P = 8.66 × 10−7; Fig. 1C and D). Multivariate modeling of these 2 SNPs, which are moderately correlated in HapMap subjects of European ancestry (r2 = 0.74), showed that rs8170 is more strongly associated with triple-negative breast cancer risk (rs8170: OR = 1.22, 95% CI = 1.10–1.34; P = 7.56 × 10−5; rs8100241: OR = 0.90, 95% CI = 0.83–0.98; P = 0.014), although both variants are retained in the model. In addition, rs3803662 (TOX3), which has been strongly associated with risk of ER-negative breast cancer (OR = 1.15, P = 2.1 × 10−10; ref. 19), was associated with a 1.17-fold increase in risk of triple-negative disease (OR = 1.17, 95% CI = 1.09–1.26; P = 3.66 × 10−5; Fig. 1E). Likewise, the rs999737 (RAD51L1) SNP was significantly associated with risk of triple-negative breast cancer (rs999737: OR = 0.86, 95% CI = 0.80–0.93; P = 2.96 × 10−4; Fig. 1F). In contrast, rs17468277 (ALS2CR12/CASP8; P = 0.005) was not significantly associated with triple-negative breast cancer risk after correction for multiple testing, suggesting that this result should be interpreted with caution. None of these 6 SNPs showed evidence of heterogeneity by country (Fig. 1). To further understand the influence of variants in the 6q25.1 and 19p13.1 loci on triple-negative risk, we looked for statistical interactions between the SNPs in these regions. Although there was no evidence for a statistical interaction between rs2046210 and rs1266270 (P = 0.820) at 6q25.1, we found strong evidence of an interaction (P = 0.004) between rs8170 and rs8100241 from 19p13.1 in a multiplicative model.
Next, we conducted a subset analysis using the iPLEX data alone (2,707 cases and 1,385 controls) for the 19 SNPs with both iPLEX and GWAS genotypes to assess the consistency of our results. Analysis of associations with triple-negative disease in the iPLEX-only data set showed that ORs for the 19 SNPs were consistent in both direction and magnitude of effect compared with the analysis using all available genotype data, although some variation in the significance of the associations was observed (Table 2). Four of the SNPs significantly associated with triple-negative breast cancer in the overall analysis retained statistical significance in the iPLEX-only analysis (rs12662670: P = 3.52 × 10−4; rs3803662: P = 8.25 × 10−4; rs8170: P = 7.30 × 10−8; rs8100241: P = 1.81 × 10−6) after correction for multiple testing. Results were unchanged for rs2046210 from the ESR1 locus, because the overall analysis was restricted to iPLEX data as a result of missing GWAS data for this variant. Finally, although the rs999737 (RAD51L1) SNP was only marginally associated with triple-negative breast cancer risk in the iPLEX-only analysis (rs999737: P = 0.053), the estimate of effect for this SNP was consistent with the effect observed in the overall analysis.
Importantly, genotype data from a subset of these cases and controls have previously been used in association studies involving a number of these SNPs by the Breast Cancer Association Consortium (BCAC). To avoid duplication and to assess the degree to which these BCAC samples influenced our results, we also conducted a subset analysis in which we excluded all cases and controls used in the BCAC studies (n = 1,819 cases and n = 4,038 controls; Supplementary Table S4). The effect estimates and significance of associations with triple-negative disease in either the iPLEX or combined analyses were not substantially modified following the removal of these cases and controls (Supplementary Table S5).
Here, we report on the first study by the TNBCC and the largest study to date of genetic susceptibility to triple-negative breast cancer, which is composed of 2,980 cases and 4,978 controls from 25 studies in 9 countries. We show that a subset of breast cancer susceptibility SNPs identified through GWAS is also associated with risk of triple-negative breast cancer. Specifically, we determined that 6 breast cancer susceptibility SNPs from 4 loci, rs2046210 (ESR1), rs12662670 (ESR1), rs999737 (RAD51L1), rs3803662 (TOX3), rs8170 (19p13.1), and rs8100241 (19p13.1), are associated with risk of triple-negative breast cancer. Of these, rs8170 (19p13.1) achieved genome-wide significance (P = 2.25 × 10−8). Overall, these findings provide strong evidence of genetic susceptibility to triple-negative breast cancer.
We identified highly significant associations between SNPs at 6q25.1, including rs12662670 (P = 1.13 × 10−4) and rs2046210, which reached near genome-wide significance (P = 4.38 × 10−7), and risk of triple-negative breast cancer. These variants are located approximately 30 and 60 kb upstream of the first untranslated exon and 180 and 210 kb upstream of the first coding exon of ESR1, which encodes the ERα protein.
The rs2046210 SNP was originally reported in a breast cancer GWAS in Chinese women (13), where a stronger association was observed among ER-negative than among ER-positive breast cancer cases. Importantly, the magnitude of effect in this triple-negative study (OR = 1.29, 95% CI = 1.17–1.42) was identical to that reported for ER-negative breast cancer in the Chinese study (OR = 1.29, 95% CI = 1.21–1.37). In contrast, a study of women of European ancestry did not observe an association with breast cancer, although analyses were not stratified by ER status (28). When combined with our results, the suggestion is that this SNP may be specifically associated with triple- or ER-negative disease. The second variant in the ESR1 locus rs12662670 was originally associated with breast cancer in the same study of women of European ancestry (OR = 1.12, 95% CI = 1.03–1.21) and was used as a surrogate for rs9397435, which is associated with breast cancer risk (OR = 1.15, 95% CI = 1.06–1.25) independently of rs2046210 (28). Here, rs12662670 showed a strong influence on triple-negative breast cancer risk (OR = 1.33, 95% CI = 1.15–1.53), again suggesting that variation in the ESR1 locus is specifically associated with risk of ER-negative and/or triple-negative breast cancer. It remains to be determined whether a single locus represented by rs2046210 or 2 loci accounted for by rs2046210 and rs9397435 are associated with ER-negative and triple-negative breast cancer at chromosome 6q25.
Because triple-negative breast cancer is defined in part by the absence of expression of ERs, we can speculate that inherited variation may downregulate ESR1 expression and promote formation of ERα-negative tumors. However, recent studies in mice have shown that the mammary stem cell compartment can be regulated by 17β-estradiol and progesterone through a paracrine-signaling mechanism from steroid receptor–positive luminal cells to steroid receptor–negative stem cells (29, 30). Thus, SNPs in the ESR1 locus may promote expansion of receptor-negative precursors and subsequent development of triple-negative tumors. Interestingly, variation in the 5′ region of ESR1 has been associated with an increased risk of breast cancer relapse in a British prospective cohort study (31), which was accounted for by including tumor grade and nodal status in multivariate models. Thus, the causal SNPs in this area may be associated with a more aggressive tumor phenotype.
The SNPs rs8170 (P = 2.25 × 10−8) and rs8100241 (P = 8.66 × 10−7) located at 19p13.1 were first identified both as modifiers of breast cancer risk in BRCA1 carriers (15) and as risk factors for ovarian cancer (32), as well as shown to be significantly associated with ER-negative breast cancer (15). In this study, we showed that rs8170 displayed a genome-wide significant association with triple-negative breast cancer, suggesting that we can now identify variation in the 19p13.1 locus as a risk factor for triple-negative disease. Interestingly, rs8170 attenuated the significance of rs8100241 when the SNPs were included in a multivariate regression model for breast cancer whereas both these SNPs retained significance in multivariate models evaluating effects on BRCA1-associated breast cancer and ER-negative breast cancer (15). In addition, our data suggest that these SNPs have a multiplicative effect on triple-negative breast cancer risk. Further studies are required to determine whether these SNPs represent independent signals in the 19p13.1 locus. Additional studies are also needed to identify the underlying causative genetic events in this locus and to determine whether the causative events for BRCA1, ER-negative, and triple-negative breast cancer as well as ovarian cancer are common.
These 19p13.1 variants are located in a cluster of genes including C19orf62, ANKLE1, and ABHD8. ABHD8 encodes the abhydrolase domain containing 8 protein, which is a gene of uncharacterized function, and is located about 13 kb downstream of both rs8170 and rs8100241. The SNP rs8170 is located within C19orf62, which encodes the MERIT40 protein, whereas rs8100241 is located within ANKLE1, a protein of unknown function that encodes ankyrin repeat and LEM domains. MERIT40 is the most plausible candidate in this region for breast cancer susceptibility because it is a component of the BRCA1-A complex and is required to ensure the integrity and localization of this complex during the repair of DNA double-strand breaks, specifically through the recruitment and retention of the BRCA1–BARD1 ubiquitin ligase and the BRCC36 deubiquitination enzyme (33–35). However, it remains to be determined whether the causal variants at 19p13.1 alter MERIT40 expression or function or influence other genes in the region such as ANKLE1 or ABHD8.
We also found that variants in RAD51L1 (rs999737: P = 2.96 × 10−4) and TOX3 (rs3803662: P = 3.66 × 10−5) were strongly associated with risk of triple-negative breast cancer. rs999737 (RAD51L1) was originally identified in a recent breast cancer GWAS of women of European ancestry (12). Detailed studies of breast tumors have suggested that rs999737 is associated with both ER-positive and ER-negative breast cancers, which is consistent with our findings. RAD51L1 is a member of the Rad51-like family and functions in the double-strand break repair and homologous recombination pathway (36). When coupled with the association of the 19p13.1/MERIT40 locus with triple-negative risk, the suggestion is that modification of DNA repair genes is an important mechanism involved in predisposition to triple-negative breast cancer. The SNP rs3803662, located telomeric to the gene TOX3, was also strongly associated with triple-negative breast cancer in our study (P = 3.66 × 10−5). This SNP was originally identified in 2 GWASs of breast cancer (7, 9) and has been associated with risk of developing both ER-positive and ER-negative tumors (9). The SNP is also associated with the risk of BRCA1-related breast cancers (15), which are primarily ER-negative or triple-negative. TOX3 encodes a protein containing an HMG-box that is speculated to be involved in the modification of DNA and chromatin structure (37).
Only a subset of the 22 susceptibility loci was associated with triple-negative disease in this study. This suggests that there may be heterogeneity in the predisposition loci associated with different breast tumor subtypes. However, it is important to consider whether limited statistical power may have influenced our results. Among the 16 SNPs that did not reach statistical significance in this study, the effect estimates for variants at 1p11.2, 2q35, 8q24, 9q31.2, 10p15.1, 10q21.2/ZNF365, 10q22.3/ZMIZ1, and FGFR2 either showed no evidence for association or were in the opposite direction compared with the original GWAS findings. Interestingly, 2q35 has been associated with both ER-negative (19) and BRCA1-related breast cancers (21) and was marginally significant in a smaller set of triple-negative breast cancer (19). However, we found no evidence for the association at 2q35 among triple-negative breast cancer, indicating that risk for this locus may be limited to non–triple-negative and ER-negative breast cancer. In contrast, the ORs for SNPs at CASP8, 9p21.3, and COX11 were comparable in magnitude with the original GWAS findings, whereas the ORs for variants at 3p24/NEK10, 5p12, MAP3K1, LSP1, and 11q13 had only mildly attenuated effects. Our results are also consistent with a recent study reporting associations between MAP3K1, 3p24/NEK10, COX11, and CASP8 and ER-negative breast cancer (19). These results suggest that we may have had insufficient power to detect significant associations for these SNPs among triple-negative breast cancers.
Several limitations should be considered when interpreting these results. First, different ascertainment criteria were used among the contributing breast cancer studies, with cases being ascertained from population-based or hospital-based case–control studies. Importantly, genetic main effects models in other large breast cancer consortia such as BCAC have provided stable risk estimates for SNPs across a wide range of study designs. This would suggest that in the case of these genetic variants, ascertainment and study design issues had limited influence on the results of genetic association studies for breast cancer. The consistency in effect estimates among BRCA1-related breast cancers, ER-negative breast cancer, and now triple-negative breast cancer for variants at 19p13.1, 6q25, and TOX3 provides additional evidence that these estimates are robust to variability in study design. Furthermore, our evaluation of interactions with age was underpowered, and unavailability of family history on most studies precluded investigations of interactions by family history. There is also variability in the criteria used to define the status of ER, PR, and HER2 of cases between studies (Supplementary Table S2). For HER2, cases with scores of 0 or 1 by IHC were defined as HER2 negative. Cases with IHC of 2+ were not included to minimize erroneous inclusion of HER2-positive cases. In general, cases were considered ER- or PR-negative on the basis of IHC of tumors using thresholds of less than 1% of cells stained, less than 10% of cells stained, or an Allred score of 0 to 2, which incorporates both intensity and percentage of staining in tumor cells. In addition to variability in thresholds for positivity, factors such as tissue fixation, antibody choice, and interpretation of positive immunostaining may also affect the definition or the status of ER or PR across study sites (38, 39). The resulting heterogeneity in the definition of triple-negative breast cancer may influence our ability to detect associations with susceptibility loci that are specific to triple-negative or ER-negative disease. However, we did successfully identify 6 genetic loci associated with triple-negative disease, and the lack of heterogeneity in effect estimates across study sites in this analysis (Fig. 1) would suggest that our findings are generally robust to the differences noted earlier. In addition, in a sensitivity analysis including only cases from studies with the most stringent criteria for defining triple-negative cases (<1% of cells stained positive for ER and PR, HER2 0 or 1+ on IHC), the effect estimates were very similar to those from the complete analysis for the 6 SNPs in ESR1, 19p13.1, TOX3, and RAD51L1, with some attenuation of significance. Finally, it is important to note that the results of this study are specific to Caucasian women. Although greater proportions of African Americans and Latinas than do Caucasians develop triple-negative breast cancer, it is not known whether similar associations with the SNPs described here exist in these populations. Further studies are needed to address this question.
In conclusion, our study provides convincing evidence for genetic susceptibility to triple-negative breast cancer and suggests that susceptibility loci may differ by histologic breast tumor subtype, defined by the status of ER, PR, and HER2. These findings add to the evidence suggesting that these subtypes likely arise through distinct etiologic pathways. Additional studies, such as those from the BCAC, will be important for determining whether these SNPs are exclusively associated with ER-negative, triple-negative disease, or even basal breast cancer, a more refined subgroup of triple-negative tumors. Fine mapping and functional analyses of these susceptibility loci are needed to identify the casual variants and mechanisms underlying the associations with triple-negative breast cancer risk.
Disclosure of Potential Conflicts of Interest
No potential conflicts of interest were disclosed.
Grant Support
Mammary Carcinoma Risk Factor Investigation (MARIE)
The MARIE study was supported by the Deutsche Krebshilfe e.V. grant 70-2892-BR I, the Hamburg Cancer Society, the German Cancer Research Center (DKFZ), and the DNA extraction and genotype work in part by the Federal Ministry of Education and Research (BMBF) Germany grant 01KH0402.
Gene Environment Interaction and Breast Cancer in Germany (GENICA)
The GENICA Network was funded by the Federal Ministry of Education and Research (BMBF) Germany grants 01KW9975/5, 01KW9976/8, 01KW9977/0, and 01KW0114, the Robert Bosch Foundation of Medical Research, Stuttgart, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, and University Tübingen, Germany (H. Brauch, Christina Justenhoven); Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany (U. Hamann); Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany (Y.-D. Ko, Christian Baisch); Institute of Pathology, Medical Faculty of the University of Bonn, Germany (Hans-Peter Fischer); and Institute for Prevention and Occupational Medicine of the German Social Accident Insurance (IPA), Bochum, Germany (Thomas Brüning, Beate Pesch, Volker Harth, and Sylvia Rabstein).
Melbourne Collaborative Cohort Study (MCCS)
The MCCS was supported by Australian NHMRC grants 209057, 251553, and 504711 and infrastructure provided by the Cancer Council Victoria.
Sheffield Breast Cancer Study (SBCS)
The SBCS was supported by the Breast Cancer Campaign (grant 2004Nov49 to A. Cox) and by Yorkshire Cancer Research core funding.
Dana Farber Cancer Institute (DFCI)
This work was supported in part by the DFCI Breast Cancer SPORE NIH P50 CA089393.
Prospective Study of Outcomes in Sporadic Versus Hereditary Breast Cancer (POSH)
The POSH study (CI: D.M. Eccles) was funded by Cancer Research UK. Blood samples were collected by the University of Southampton Cancer Sciences Human Tissue Bank (HTA license 12009).
Molecular Diagnostics Laboratory IRRP, National Centre for Scientific Research (DEMOKRITOS)
This work was supported by the Hellenic Cooperative Oncology Group research grant (HR R_BG/04) and the Greek General Secretary for Research and Technology (GSRT) Program, Research Excellence II, funded at 75% by the European Union.
Bavarian Breast Cancer Cases and Controls (BBCC)
P.A. Fasching was partly funded by the Dr. Mildred Scheel Stiftung of the Deutsche Krebshilfe e.V.
British Breast Cancer Study (BBCS)
The BBC NCRN study is funded by Cancer Research UK and Breakthrough Breast Cancer and acknowledges NHS funding to the NIHR Biomedical Research Centre and the National Cancer Research Network (NCRN).
Leuven Multidisciplinary Breast Centre (LMBC)
LMBC is supported by European Union Framework Programme 6 Project LSHC-CT-2003-503297 (the Cancerdegradome) and by the "Stichting tegen Kanker" (232-2008).
Oulu Breast Cancer Study (OBCS)
OBCS was supported by grants and other funding from the Finnish Cancer Foundation, the Sigrid Juselius Foundation, the Academy of Finland, the University of Finland, and Oulu University Hospital.
Mayo Clinic Breast Cancer Study (MCBCS)
MCBCS was supported by NIH grants CA122340 and a Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201) and grants from the Komen Foundation for the Cure and the Breast Cancer Research Foundation (BCRF).
Study of Epidemiology and Risk factors in Cancer Heredity (SEARCH)
SEARCH was supported by Cancer Research UK grants C1287/A7497, C490/A11021, C1287/A10118, and C1287/A5260.
Helsinki Breast Cancer Study (HEBCS)
The HEBCS study has been financially supported by the Helsinki University Central Hospital Research Fund, Academy of Finland (132473), the Finnish Cancer Society, and the Sigrid Juselius Foundation.
Fox Chase Cancer Center (FCCC)
A.K. Godwin was funded by SPORE P-50CA83638, U01CA69631, 5U01CA113916, and the Eileen Stein Jacoby Fund.
Roswell Park Cancer Institute (RPCI)
Data and samples were obtained from the RPCI Data Bank and BioRepository (DBBR; ref. 40), a Cancer Center Support Grant Shared Resource (P30 CA016056-32).
Städtisches Klinikum Karlsruhe and Deutsches Krebsforschungszentrum Breast Cancer Study (SKKDKFZS)
The SKKDKFZS study was supported by the Deutsches Krebsforschungszentrum.
Breast Cancer in Galway Genetic Study (BIGGS)
E. Sawyer is funded by the National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London and King's College Hospital NHS Foundation Trust.
Australian Breast Cancer Tissue Bank (ABCTB)
The ABCTB is generously supported by the National Health and Medical Research Council of Australia, The Cancer Institute NSW, and the National Breast Cancer Foundation.
Amsterdam Breast Cancer Study (ABCS)
M.K. Schmidt was funded by the Dutch Cancer Society grant 2009-4363.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
Mammary Carcinoma Risk Factor Investigation (MARIE)
MARIE thank Tracy Slanger and Elke Mutschelknauss for their valuable contributions and S. Behrens, R. Birr, W. Busch, U. Eilber, B. Kaspereit, N. Knese, and K. Smit for their excellent technical assistance.
Melbourne Collaborative Cohort Study (MCCS)
The authors acknowledge the contribution of the MCCS investigators John L. Hopper, Dallas R. English, and Melissa C. Southey.
Sheffield Breast Cancer Study (SBCS)
The authors thank Helen Cramp, Dan Connley, and Ian Brock for patient recruitment, database management, and DNA preparation, respectively.
Prospective Study of Outcomes in Sporadic Versus Hereditary Breast Cancer (POSH)
The authors thank the 126 participating investigators who recruited cases to the study and the NCRN for supporting recruitment to the study.
Leuven Multidisciplinary Breast Centre (LMBC)
LMBC thanks Gilian Peuteman, Dominiek Smeets, and Sofie van Soest for technical assistance.
Mayo Clinic Breast Cancer Study (MCBCS)
The authors thank Georgia Chenevix-Trench for her valuable contributions.
Helsinki Breast Cancer Study (HEBCS)
HEBCS thanks R.N. Hanna Jäntti and Irja Erkkilä for their help with the patient data and samples and Drs. Päivi Heikkilä, Ari Ristimäki, Tuomas Heikkinen, Mira Heinonen, and Laura Hautala for their help with the tumor marker and pathology information and gratefully acknowledges the Finnish Cancer Registry for the cancer data. The population allele and genotype frequencies were obtained from the data source funded by the Nodic Center of Excellence in Disease Genetics based on samples regionally selected from Finland, Sweden, and Denmark.
Breast Cancer in Galway Genetic Study (BIGGS)
The authors thank Drs. Gabrielle Colleran, Niall McInerney, Nicola Miller, and Prof. Michael Kerin, University Hospital Galway, for their help in collecting patient data and samples.
Amsterdam Breast Cancer Study (ABCS)
The authors thank ABCS/BOSOM study collaborators, among others L.J. Van't Veer, F.E. van Leeuwen, R. van Hien, S. Cornelissen, A. Broeks, and A.J. van den Broek, and the NKI-AVL Family Cancer Clinic, especially F.B. Hogervorst.
Australian Breast Cancer Tissue Bank (ABCTB)
R.L. Balleine is a Cancer Institute New South Wales fellow.
Oulu Breast Cancer Study (OBCS)
The authors thank Mervi Grip and Kari Mononen for their help with patient contacts and sample and data collection and Meeri Otsukka for assistance with sample and data handling.
Kuopio Breast Cancer Project (KBCP)
KBCP is grateful to Mrs. Eija Myöhänen and Mrs. Helena Kemiläinen for their skillful assistance.
Note: Supplementary data for this article are available at Cancer Research Online (http://cancerres.aacrjournals.org/).
- Received April 12, 2011.
- Revision received July 27, 2011.
- Accepted July 27, 2011.
- ©2011 American Association for Cancer Research.


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WASHINGTON D.C. - The Trail Political Action Committee (TPAC) is proud to announce its official endorsement and support for Claudia Tenney who is running for election to the U.S. House of Representatives in New York's 22nd congressional district.
Congressional candidate Claudia Tenney states, "I am a strong supporter of family-oriented outdoor recreation and believe the public should have access to those high-quality activities which include, mountain bikes, all-terrain vehicles, hunting, fishing, rock climbing, and hiking. If elected, I will fight against unreasonable rules and regulations that impact a user's right to enjoy outdoor recreation on public and private lands."
TPAC believes this battleground race is critical to help us retain our pro-trail majority in the House of Representatives. TPAC wants to join forces with other pro-trail voters in New York in an effort to send Claudia Tenney to the House on November 8.
TPAC works to elect federal candidates who will support legislation and policy that promotes and protects responsible off-highway vehicle recreation on public and private lands.


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VIDEO: Blue and Gold Madness 2019 ft. WIZ KHALIFA
October 13, 2019
With the help of Pittsburgh native and rap star Wiz Khalifa, the Oakland Zoo gets hyped up for the 2019/20 Men's and Women's basketball season. Guest appearances from Pittsburgh Steelers players James Conner, Ryan Shazier, and Juju Smith-Schuster!
Column: Le'Veon Bell due to return Week 7
By Trent Leonard, Sports Editor
October 2, 2018
After a difficult week for football in Pittsburgh, fans can look towards some good news. It seems Steelers' running back Le'Veon Bell is expected to return to the game in Week 7. Bell's return will help the Steelers make a major comeback after a few hard weeks on both defense and offense.
Former Panthers poised for success this NFL season
By Colin Martin, Staff Writer
August 31, 2018
The SEC isn't the only institution that produces notable football players -- the ACC does as well. As the NFL is underway, the Pitt News reviews major former Panther's that can positively impact their respective teams.
Panther plunders: Pitt's worst homecoming games
By Brandon Glass | Staff Writer
October 12, 2017
While the homecoming court trots out onto the field at halftime this Saturday — and two lucky students are crowned king and queen — the Panthers will be in the locker room discussing strategy, diagramming plays and trying to figure out how to make the biggest home game of the season count. As...
Gallery: Pitt vs Youngstown State
By Anna Bongardino and Wenhao Wu | Assistant Visual Editors
September 2, 2017
In the season opener, Pitt beat Youngstown State 28-21 in overtime. (Photo by Anna Bongardino | Assistant Visual Editor) (Photo by Wenhao Wu | Assistant Visual Editor) (Photo by Wenhao Wu | Assistant Visual Editor) (Photo by Wenhao Wu...
Pitt alters "Sweet Caroline" tradition
By Ryan Zimba / Sports Editor
August 25, 2017
Ahead of its opening week game against the Youngstown State Penguins next Saturday, the Pitt football program announced Friday its nine-year tradition of singing "Sweet Caroline" at the end of the third quarter has come to an end. The tradition, which started during Pitt's 2008 game against t...
ICYMI: Summer sports timeline
By Ryan Zimba / Sports Editor
August 22, 2017
April 28 - Football head coach Pat Narduzzi dismisses senior defensive tackle Jeremiah Taleni for disciplinary reasons. April 28-29 - Five Panthers are selected in the 2017 NFL Draft, including James Conner, who the Steelers picked in round three. May 2 - Gymnastics head coach Debbie Yohman ret...
Pitt to honor James Conner with bobblehead
By Ryan Zimba / Sports Editor
August 17, 2017
The Pitt athletic department announced Thursday there will be a James Conner bobblehead night to honor the former running back at the team's Oct. 14 homecoming game against the North Carolina State Wolfpack. The bobblehead — featuring Conner wearing Pitt's throwback uniform — will be given ...
The next chapter: Conner's story continues in Pittsburgh
By Ryan Zimba | Sports Editor
May 9, 2017
Sitting with friends and family in his hometown of Erie, Pennsylvania, James Conner watched as the NFL Draft progressed through the first three rounds. Conner — a projected fifth or sixth round pick — probably wasn't surprised he was still on the board. But as the night came to a close, the Pitt ...
Storify: Twitter reacts to Steelers' selection of James Conner
By Steve Rotstein | Senior Staff Writer
April 29, 2017


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NCRI – With the rise of the 1988 Justice-Seeking Movement, Iranian regime's President Hassan Rouhani was forced to dismiss his Justice Minister, Mostafa Pour Mohammadi, from his cabinet. Pour Mohammadi was a member of the "Death Committee" and one of the main perpetrators of the massacre of 30,000 political prisoners in the summer of 1988. He announced that he would not be present in Rouhani's next administration.
In addition, Rouhani's Legal Deputy, Majid Ansari, another perpetrator of the 1988 massacre, announced that he will not be present in Rouhani's future cabinet too.
On the other hand, on the eve of the start of Rouhani's second term, some government media outlets affiliated to Rouhani's band announced his retreat from the rival gang after his brother was arrested. The media wrote: "Before the arrest of Hossein Fereydoon, the promising news of the new cabinet was transmitted, but then, disappointing news is published every day."


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I just finished uploading this Condo for sale, 603 175 2ND STREET, North Vancouver, BC
Lower Lonsdate at its best ! It is my pleasure to introduce you to the best 2 bedroom and den floor plan at the Ventana, one of the Lower Lonsdale's best buildings- This 6th floor unit offers westerly views of the Lions Gate Bridge and North Shore mountains and gorgeous sunsets! This property is walking distance to the Lonsdale Quay, shops, restaurants, transportation and most amenities-Open Sunday 2-4


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Spectacular slides in one of Europe's largest water parks for action and pure adrenalin. Everyone, young or old, will have fun in the Rio Mare river bath and the indoor wave pool.
For rest and relaxation, visit the Alpa-Therme pool in the 36°C iodine saline thermal bath. Stay a little longer at the Alpamare to enjoy a sauna or a soothing massage in the wellness area.
Twelve amazing slides are available at the Alpamare water park. The "Jungle Run" is a battle between two rivals along a 220 meter slide, while the "IceXpress" includes a 17 meter drop and some "icy" surprises. If you take the "Cresta Canyon", you will experience that special outdoor feeling on a rubber raft. Or choose the "Tornado", where you tumble and twist at high speed through three or four laps before jumping off to land at the finish.
The wave pool offers fun and entertainment with waves of about 1,20 meter. Or try out the Rio Mare river pool and drift in the current, faster at times, then slower. In the outdoor Alpa-Therme pool you can fully relax in the warm water, resting on a bubble lounger, with underwater music.
A bio sauna, a Finnish sauna and a steam bath are all part of a soothing wellness program. Detoxification with Rassoul ceremonies in a steam bath and cleansing brush massages are available anytime at the wellness desk.
Various massage and wellness packages for complete relaxation. More on this at
Opening hoursAdmission tickets are available online
Purchase your ticket easily in the PostBus App.
Download the PostBus App now
View timetable online
For groups of 10 and more, seat reservations are necessary (see Contact)
Route open all year
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PostBus Ltd
St. Leonhard-Strasse 20
9000 St. Gallen
Telephone+41 58 386 73 44
No bicycle transport fixtures available in/on the vehicle
Wheelchair access to the postbus guaranteed (only manual wheelchairs)
Route 3, Alpenpanorama-Weg
Route 4, Via Jacobi
Route 69, Züri Oberland-Höhenweg
Route 84, Zürichsee-Rundweg
suitable for wheelchairs


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Menendez: Transportation Bill Ignores National Crisis, Fails to Address Aging Hudson River Rail Tunnels
Menendez: Transportation Bill Ignores National Crisis, Fails to Address Aging Hudson River Rail Tunnels
Menendez: Transportation Bill Ignores National Crisis, Fails to Address Aging Hudson River Rail Tunnels
WASHINGTON, D.C. – U.S. Senator Bob Menendez, Ranking Member of the Senate mass transit subcommittee, today issued the following statement following his no vote on a six-year Senate transportation bill:
"This is a transportation bill that ignores the transportation crisis in this country. It does not provide enough money to keep mass transit running, let alone make substantial improvements to our aging infrastructure. This bill does not do enough to advance Gateway and it disregards what we learned after the horrible train crash in Philadelphia by delaying implementation of Positive Train Control, which we know would have prevented the tragedy and saved lives.
"Our transportation infrastructure is literally crumbling. Our nation's bridges are dilapidated, our roads falling apart, and Amtrak's rail tunnels under the Hudson River are dangerously nearing the end of their life, stranding commuters, and putting in peril the vitality of the Northeast's regional economy. We have serious problems that require serious solutions that adequately address our pressing transportation infrastructure needs.
"We can't do this on the cheap. We need long-term, robust funding to ensure our transportation system is safe and reliable, not a series of band-aids and a bill that falls painfully short of achieving either."
The Senator pointed to the following specific failures in the bill:
- Commits to a six-year authorization but only provides three years of funding—creating a Highway Trust Fund cliff in the middle of the bill
- Creates a private-sector transit New Starts program that allows projects with significant private sector involvement in designing, building, operating, or maintaining transit projects to jump to the front of the line for federal money
- Provides a disproportionate increase to transit programs that help rural States and smaller increases to transit programs that help New Jersey
- Contains a number of problematic safety provisions including a pilot program to allow 18 year-olds to drive commercial trucks, underfunding Positive Train Control, and a repeal of new braking standards for crude oil trains
- Contains a number of problematic environmental provisions, including allowing for more road-building in Clean Air Act nonattainment areas
- Offset by a number of controversial non-transportation pay-fors including a tax on mortgages, aviation and Customs fees, and a sale of Strategic Petroleum Reserve assets.


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About Us
Lions Deli was created in November 2015 as a development and financial services company offering consultation and capital sourcing for b2b, b2c, and p2p clients: We offer resources to developers/contractors, investors, small businesses, and financial institutions. Our experience and expertise in these markets has allowed us to build an ecosystem for efficient planning, borrowing, and building.
Founder -
Michael Saks Gradington
I have over 15 years experience in commercial/residential-development and finance (small business lending and construction finance). From High Rise project management to loan origination on conventional bank loans, I have successfully had my hands in most facets of these industries. I started Lions Deli with the two primary intentions:
1. Helping businesses source capital.
2. Offering my expertise and creativity to new and seasoned builders.
Along with sourcing the debt or equity we offer advisory/design services to scenarios which surround the need for funds. For example, if a builder requires a loan for a new development; not only can we obtain the loan, but we also offer architectural design, cost analysis, and project feasibly services. By doing this we create an environment with our clients where they can depend on us to leverage their production and cost every step of the way.
We are currently operating as a small boutique-brokerage, but the ultimate goal is to be a direct lender to businesses and urban developer. I do not ever want to get rid of the service side, because I believe that smarter clients make for strong partnerships and viable communities.
I was born and raised in Long Beach California. I am a husband and father. My only real hobby is online chess.


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Bib Apron | Rainbow Stripes
$ 35.00
Vibrant Rainbow stripe bib apron is eye catching in the kitchen, at the grill or in the garden. Long ties at the waist and neck make it adjustable and comfortable. Double front pocket is a handy place for your tools or towels. Durable cotton will last for many washings.
Matching dish towels and pot holders are available.
28" L x 27" H with 32" ties.
Handwoven in 100% cotton.
Easy care machine washable and dryable.


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Data Just Right
A Practical Introduction to Data Science Skills
Michael Manoochehri
UCB iSchool MIMS Alum, 2010
Google, Inc / Google Cloud Platform, Data
Author of upcoming book "Data Just Right"
So, where are we? Why is this all so confusing?
Collecting and Serving Large Datasets
Building out the Data Pipeline Pattern
Telling the Story: Narrative Tools
A push toward everything "In the Cloud"
My Suggestions for becoming a "Data Scientist"
"a cultural, technological, and scholarly phenomenon that rests on the interplay of technology, analysis, and mythology that provokes extensive utopian and dystopian rhetoric." - danah boyd & Kate Crawford (Critical Questions for Big Data)
"Big data is what happened when the cost of storing information became less than the cost of making the decision to throw it away." - George Dyson
Rapid innovation in the data technology space is the result of open source technology, commodity hardware, accessibility of cloud computing, major success stories in data-driven applications, innovations in visualization techniques, and feeling of opportunity for human creativity to produce novel insights.
The cliffhanger: What do we need to invest in?
Despite the (IMO) unfortunate term, defining the role of "Data Scientist" is important to identify, and to help define this increasingly important role in organizations.
Hilary Mason: Getting Started with Data Science
"...data scientists do three fundamentally different things: math, code (and engineer systems), and communicate." - Hilary Mason
DJ Patil: What is a Data Scientist?
"It's a high-ranking professional with the training and curiosity to make discoveries in the world of big data... If your organization stores multiple petabytes of data, if the information most critical to your business resides in forms other than rows and columns of numbers, or if answering your biggest question would involve a "mashup" of several analytical efforts, you've got a big data opportunity."
Sean Taylor: Scientists make their own Data
"Many social/digital scientists are reluctant to invest in making data because it's much more costly and risky than analyzing data you already have available." - Sean Taylor
Example 1: Hosting and sharing large amounts of data
It's not as easy as just throwing a bunch of files into a cloud storage provider.
Example: Library of Congress Twitter Archive
Goal: Understand who the audience is, what your budget dictates,
Example 2: Collecting large amounts of data
Example needs:
This versus that versus this versus that
Tendency for confusion around use cases, results in re-inventing the wheel, and incredible niche technology. Example: Cassandra vs MongoDB vs CouchDB vs Redis vs Riak vs HBase vs Couchbase vs Neo4j vs Hypertable vs ElasticSearch vs Accumulo vs VoltDB vs Scalaris
A common pattern often seen in this space is the use of a schema-less non-relational database to collect data, a read-only structured schema analytics databases are being used to run queries quickly over this data, with MapReduce transformation step in the middle.
Because of the process for open-source application, there is a lot of "mismatch" between the tools needed to build this pipeline pattern.
Collecting data: High availability, scaleable, partition-tolerant database
Processing and transforming data
Fast, aggregate query tool for asking quick queries about your data
Tools for Collaborative Mathematical and Statistical Analysis
R (versus?) Python
Recommendation: For practical data applications, explore the growing, if perhaps incomplete, set of Python-based tooling of Numpy, SciPy, Matplotlib, Pandas, and especially iPython
Visualization tools
Visualization is a rich field with much cultural history (and the potential for telling a dishonest story).
There are a multitude of tools, both commercial and open source, for exploring data visually, such Tableau, QlikView, Gephi, etc
Building your own, or graphing as you explore:
Sharing on the web - JavaScript Visualization libraries
//staq: Understanding Players using near-real time data analytics
Combination of technologies: memSQL and BigQuery
Support "real-time" analytics with MemSQL, and aggregate analytics with BigQuery, along with a
Visualizing all the Ships in the World
Using a variety of collection and caching techniques to build a robust data processing application
Are there 5 positions in the NBA... or 13?
Topological visualization using clustering
Convergence: Tools that offer a best of many worlds
What will be automated, what will require even more skilled professional... humans?
Short term skills:
Moving and asking questions about data
Distributed Data tools
Long term skills:
Dive into statistics


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The Rainforest team has been working very hard over the past few months to ship a ton of updates to our app. Over the coming months we have some MAJOR performance improvements to the underlying Rainforest platform, but for now let's look at what we've shipped to improve the performance of Rainforest's interface.
Hi there beautiful
That's pretty much all there is to it. It works great. Currently searches titles only - full-text search and find-and-replace coming soon.
When we built Rainforest's frontend, we didn't really anticipate the hundreds of tests our power users would put into the system. You might say that was quite the oversight, and you'd be right. In any case, we fixed it.
Rainforest at the speed of .gif
We'll cover the whole skinny in a later post, but basically we paginated the results, so our customers with 1000+ tests don't die from frustration, and consolidated what used to be n HTTP requests (n being the number of tests in your suite) to a single request. This was achieved by moving filtering to the backend. What that also means is that our API natively supports all the filters that you see on rainforestqa.com. Which is cool.
Tests are now displayed in a modal, wherever you are on the site. This means you never lose your context, and makes the site feel much snappier. We also fixed a persistent and frustrating bug that would mess with the URL history when loading a specific test. URL state is now stored internally in our app, so going back or forwards in your browser works consistently (this is less trivial than it sounds with single-page apps).
We streamlined the step editor to make it simpler and more awesome, and hid the optional functionality. Mostly we want to let you focus on the steps, so you can get your job done quickly.
One of my favorite details is that when either input is empty, a 'new examples' link is displayed. Click new examples and we cycle through a bunch of example steps for your perusing pleasure.
Next up for the step editor: keyboard shortcuts!
So much cool stuff. Seriously. We're really excited. In the meantime, if you have any feedback on this release then please get in touch!


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Mahoney, D.J. The Conservative Foundations of Liberal Order: Defending Democracy Against ITS Modern Enemies and Immoderate Friends (Forthcoming). ISI Books, January 2011.
With Edward E. Ericson, Jr., Professor Mahoney is the editor of The Solzhenitsyn Reader: New and Essential Writings, 1947-2005. ISI Books, 2006.
Mahoney, D.J. Bertrand de Jouvenel: The Conservative Liberal and the Illusions of Modernity. ISI Books, 2005.
Mahoney, D.J. Aleksandr Solzhenitsyn: The Ascent From Ideology. Rowman & Littlefield, 2001. (Appeared in a revised and augmented French edition as Alexandre Soljenitsyne: En finir avec l'ideologie, Fayard, 2008).
Mahoney, D.J. De Gaulle: Statesmanship, Grandeur, and Modern Democracy. Praeger, 1996 (revised paperback edition, Transaction Publishers, 2001).
Mahoney, D.J. The Liberal Political Science of Raymond Aron. Rowman & Littlefield, 1992. (A French edition appeared in 1998).
Professor Mahoney is the author of over one hundred twenty introductions, books, articles, and book reviews that have appeared in a wide range of scholarly and public journals. His writings have appeared in French, Italian, Russian, Hungarian, Norwegian and Portuguese translation.
All Faculty Profiles
2018-2019 Course Catalog


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Kicking off the debate, Indian wind developer Rakesh Bakshi claimed his country's practice of "wheeling" electricity for a two per cent charge holds lessons for Britain. "Power is wheeled from the generator to the consumer so that wind energy can stand on its own two feet," he said. Power can also be sold direct to third parties by paying a 15% wheeling charge. "You can learn from India," advised Bakshi.
Michael Davies from Ian Pope Associates of the UK suggested an alternative to the existing electricity legislation for trading electricity. In a project funded by the European Union's Altener programme he is to look into the feasibility of a separate renewable energy "pool" that would allow consumers to purchase renewable electricity from a mix of clean power technologies.
Present electricity trading -- both in Britain and America -- came under attack for not recognising the environmental costs or externalities of fossil fuels. Several delegates called for changes to quantify the value of wind to a supply system and quantify its environmental benefits. Transmission losses are minimal with wind plant when it is embedded in a supply network, as is usually the case. "We cannot be solely dependent on the cheapest form of energy," commented US consultant Paul Gipe. "If we leave it to the political process to put a value on wind energy we will all be waiting forever," was another cynical observation.
Many, however, favoured the simplicity of the Indian example. UK wind economics expert, David Milborrow, warned, though, that assigning a true value to wind would further complicate current legislation. "How do we alight on an accurate value for wind without getting bogged down in enormous complexity?" he asked. "Whatever we do it must be simple." India had a good system which Britain should emulate, he said.
Speaking up for Britain's beleaguered distribution companies, the Regional Electricity Suppliers (RECs), Ian Parker of East Midlands Electricity pointed out that existing legislation does provide for wheeling across electricity utility borders. "The wheeling system is there for everyone to use, but if it is going to be changed it should not be in favour of one form of generation over another," he said.
The BWEA was urged to determine a plan of action to take the issue forward. New BWEA Chairman Tim Kirby endorsed the need for action but warned of the need to be pragmatic. "One of the first things we ought to tackle is OFFER's [Office of Electricity Regulation] concept of the cost to the consumer," he said, referring to the Electricity Regulator Stephen Littlechild's interpretation of the cost of renewables as the difference between NFFO contract prices and the pool price -- thereby elevating the pool price to the status of market price. The association should make strong representations to OFFER to get this concept changed, he said.


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The self-induced tortures of provincial life
Scris de Cristina Stancu • 22 July 2014 • in categoria Lit. contemporana
Author: Suzanne Berne
Publisher: Penguin Group
Year: 2013
Pages: 281
As night faded toward morning and the pizza box lay empty, the students were filled with a restless desire for even greater knowledge. Would they ever experience sex as something other than sordid and incidental? Ever be able to buy a house, lift their own children into their arms? Did life hold fierce secret joys they could not yet imagine?
They rubbed their eyes and readjusted their ear buds, then returned to Facebook. Only to find themselves glancing up every so often at their pale reflections in the dark rain-streaked windows, wondering what else was out there.
Rain, rain, rain.
The anxiety of the unknown haunts the youth of Littlefield. Existence in itself seems not totally revealed, there is always something to be waited for, another act, another twist of destiny… but until the big surprise of Fate, the characters are trapped into a tedious waiting. However, the community of Littlefield has all the chances to lead a peaceful life: the town is considered one of the Ten Best Places to live in America, quiet, well-organized, leafy, with perfect lawns, with marvellous landscapes… an ideal place where nothing peculiar ever happens. This dense serenity proves to be in fact unsettling and when the dogs are being poisoned out of the blue, the atmosphere becomes explosive – suspicion arises from every house, relationships shatter and marriages clash under the burden of the untold. It all started with an off-leash proposal for Baldwin Park, the problem was put under debate in the local council and the problem was soon abandoned because of the heated discussions between the two sides – the one claiming that dogs should be let free in the park and the opposite rising concerns about children's safety, insisting that dogs should be walked in sturdy leather collars and leashes.
This is the moment when the characters prove their insecurities and more than that, they reach to the point of showing their masks. The drama of sincerity is attentively watched by doctor Watkins, a sociologist who came to Littlefield to study the good quality of life. This voyeuristic role permits the reader to notice what kind of attitudes are adopted by the citizens in front of a stranger. All their defence mechanisms are activated, analyzed and then let aside, Watkins digging more and more to the core of their genuine conflicts. Soon, she already picks a symbol of the whole Littlefield, Margaret Downing, a housewife dogged by fears of all kinds.
She worries about Julia and dreads the moment when her teenage daughter will meet the world, cruel and careless, fascinating in the most unexpected ways. Margaret is neurotic, paranoid, she even suspects herself to be crazy… but in fact, she is an unhappy wife, torn between her duties and her secret dreams, with a high aesthetic tendency to see beauty in the trifles of everyday life. She romantically bounces from her husband to the cynical writer next door and she wonders how to transform her life into one worth living. She plays the piano, she attends the local bookclub meetings, she takes her dog for long walks, she reads whenever she finds the time, but she feels empty and her heart resonates with the entire Littlefield. Margaret is the mirror of everyone else – of Hedi's, of Emily's, of Bill's, of George's, even of Julia's, the stubborn daughter who tries to become what her mother is not.
Between the citizens of Littlefield and their anguish there are some transitional figures, apparently minor, but responsible for bulding the entire external conflict of the novel – the dogs. They reflect their masters' souls and they embody their quizzical behaviors. Dogs are dying one by one, leaving worry, anguish and sorrow, they point to the voids in human beings' life and by their last bark, they warn that comfort leaves the heart dry, smashed by the natural desire to create unsettling scenarios. The emptiness of life creeps in Littlefield as soon as the basic needs are met. Only when some secret enemy - in fact a good citizen aftel all, an insider- stirs the spirits by accidentally poisoning five dogs, the people go wild. The verdict Clarice Watkins tries to reach in her study is vaguish… she realizes that Littlefield represents the complexes of a little community lost in the vast diversity of the Globe, a group rather wealthy searching for meaning. But Clarice herself is touched by the Littlefield sindrom. She tries to heal from an emotional wound of her own by studying the scars of others, by detaching and putting their lives under the microscope. Clarice leaves in a hurry from Littlefield, realising she is on the wrong track… she can't study Littlefield as she herself has a touch of its disease.
Suzanne Berne has a rather wry style. She creates a beautiful environment, mixes the characters and make them see their world in minute detail, the objects from their homes, for example, become vital for shaping their attitudes. Margaret sees the belt buckle of George and realizes she is desperate for love. Julia heads towards school and sees a snow drift, what is odd is that the way sun patches play on the ice makes her imagine a drowning puppy and she throws herself ahead, revealing an emotional turmoil hard to be deciphered at first sight… separations issues, depression or only some typical teenager-like calls for attention? The author makes Littlefiled to echo the worries of its inhabitans and combines beautiful descriptions with sullen monologues, so the general impression is that of a balanced book, as the author called it, a social comedy about menace, but in fact reading The dogs of Littlefield proves a harsh experience, partly tedious because of the contrast between the minor problems of the characters and the fuss made around them, partly intense, given the amount of pain that human beings are able to fabricate for themselves, woven from fears and unfulfilled desires. Partly it's the same atmosphere of J.K.Rowling's Casual Vacancy, only that the narrator here in Littlefield is more compassionate. There is no need for judging, there are no major social inequalities concerned, there are no pushy factions that split the town in two obvious sides. Here in Littlefield people are shadows, they creep into each other's wounds and mirror themselves, the dog problem being only the entrance into a vicious circle of suspicion and shattered personalities.
Exquisite descriptions, intelligent associations, humorous dialogues, minor conflicts presented as breathtaking Greek tragedies.
The subject proves to have consumated itself before the end of the book.
For all of those interested by the secret intricacies of provincial life, for dog lovers and for all ambitious English learners.
Citeste cele 2 COMENTARII si spune-ti parerea!
Cine-mi recomanda si mie o carte cu si despre ORM (online reputation management)?
Nu stiu despre ORM dar review-ul a fost fain.. in special titlul.


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Parasync iPod and iPhone Docking Station
If you have several iPhones or iPods, you'll want to get your hands on the Parasync docking station, which can sync up to 20 iPhones or iPods at the same time. That's Apple overkill folks.
It's about the size of a sheet of paper. The Parasync dock is compatible with the iPhone, iPod Touch, iPod Classic and the iPod Nano. It uses only one USB cable and has been certified by Apple to work natively with iTunes. No word on pricing so far.


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3 More Conservation Posts for Chiquibul National Park
While the eyes of the nation are fixated on a departing cruise ship and a perceived threat, on Saturday the organizers of a telethon are hoping that you'll keep the Chiquibul in mind, and wallet in hand. The Friends for Conservation and Development are seeking funding to help them in monitoring and managing the massive Chiquibul National Park. The park, roughly the size of the Corozal District, has been plundered with impunity by Guatemalan encroachers. While the FCD does its thing, the Belize Defence Force is looking to enhance and expand its own role in the Chiquibul. Currently there are three conservation posts…hardly a significant presence – but there's soon be three more, fully equipped and manned twenty-four seven. The B.D.F. today called a press briefing on a number of issues, including that presence in the Chiquibul.
Brig. Gen. David Jones, Commander, Belize Defence Force
"These are the conservation posts that the B.D.F. are currently manning along the border. From the very south where the Sarstoon River is, that is the Cadenas Conservation Post then going up north to the Santa Cruz area or where you have Jalacte is where we have the Tree Tops Conservation Posts. Then a little more north, we have the Santa Rosa CP, Machaquila which is in the Columbia River Reserve and then these ones are the ones in the Chiquibul: Rio Blanco, Ciebo Chico and then the three proposed ones that we will put in place now: you are aware of Valentin which is inside the Caracol Archaeological Reserve and then the other two that will go in will be the Cebada and the Caballo Camp. Those are the three CPs that will very shortly."


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In his sophomore NBA season with the Denver Nuggetts and Team Jordan. The high school al-american and the MVP of the NCAA Tournament in his freshman year at Syracuse After carrying the team on his back with his leadership and maturity on the court then jumping from college to the pros after his spectacular season at Syracuse chosen by the Denver Nuggetts and a member of Team Jordan the best athletic team on this planet led by Michael Jordan joined by All-Stars of all sports.
Carmelo's welcome to Team Jordan his first signature shoe the Melo 1.5
Air Jordan Carmelo 1.5
The Air Jordan 1.5 Carmelo and Carmelo Anthony, of the Denver Nuggets, are the newest members of the Team Jordan; a group of pro athletes handpicked my Michael Jordan to represent the Jordan brand. This retro style shoe is clean and classic and features all of the best design features from the original Jordan shoes. A 3/4 length air sole unit and leather and vinyl mesh construction provide extraordinary comfort, the padded collar and sculpted heel brace are the ultimate in ankle and heel support, and the circular sole is personlized with Carmelo's birthday, initials, hometown, and number. Fitting notes: This shoe is wide across the midfoot/ball of the foot and narrow around the arch and heel. Zig-zag lacing provides a more personlized fit


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Sorry I'm Latte is a spring absorbing Nude Espresso Tan Brown polish.
Brand: China Glaze
Collection: House Of Colours Collection (2016)
Type: Creme
Size: 14ml / 0.5oz
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Let helpPlan My Trip
Trip Planning Made Easy
Tell us where and when you are going, with a wish list of what you want from your holiday. The best suited local guides will design tour proposals just for you. Choose your guide, and you are all set for a great holiday!
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About Uganda
Once called "The Pearl of Africa" by Winston Churchill, Uganda is a meeting point of old country beauty and progressive tourism amenities. Perhaps the truest reason for Uganda's widespread appeal is its' natural adventure, as a dense wildlife population roams the land with authority and invitation. Visitors and locals alike co-exist happily alongside the monkeys and antelopes that first called the country home. If the resident animals are Uganda's best attraction, the land they travel is a close second. With greenery, waterfalls, and deep jungle forests, the nation is a playground for adventure and photography. Its' ability to maintain a rural, 'off the beaten path' setting with safe, amenable conveniences have proven Churchill's words true even decades after they were spoken. Any Uganda tour guide knows the locals are as happy to see visitors, as visitors are to see them. A welcoming and hospitable destination, Ugandans' authentic curiosity transforms an average vacation into an unforgettable journey.


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TripAdvisor Debuts new List of "Hot New Hotels" Around Globe
Hotel & Resort James Shillinglaw October 15, 2013
TripAdvisor unveiled what it's calling its inaugural list of Hot New Hotels around the world. The hotel review website is showcasing 33 hotels in 18 countries that opened within the last year, which, according to TripAdvisor, "have provided guests with memorable experiences and have earned a minimum of four out of five bubble rating,"
Hot new hotels in the U.S. include: 21c Museum Hotel Bentonville, Bentonville, Ark.; Refinery Hotel, New York City, N.Y.; Zero George Street, Charleston, S.C.; Capella Washington D.C., Georgetown, Washington, D.C.; El Encanto by Orient-Express, Santa Barbara, Calif.; The Alexander, Indianapolis, Ind.; Hotel Vermont, Burlington, Vt.; The James Royal Palm, Miami Beach, Fla.; Weekapaug Inn, Westerly, R.I.; The Jade Hotel, New York City, N.Y.
Hot new hotels on the global list (including the U.S.) include: Hotel Casa San Agustin, Cartagena, Colombia; Kura Design Villas Uvita, Uvita, Costa Rica; Taj Palace Marrakech, Marrakech, Morocco; 21c Museum Hotel Bentonville, Bentonville, Ark.; Kempinski Hotel Cathedral Square, Vilnius, Lithuania; Mandarin Oriental Pudong, Shanghai, Shanghai, China; Refinery Hotel, New York City, N.Y.; The Ampersand Hotel, London, U.K.; Four Seasons Hotel Baku, Baku, Azerbaijan; Zero George Street, Charleston, S.C.
In addition to the U.S. and world, TripAdvisor highlighted hot new hotels in Europe and Asia. Hotels included in the ranking opened between June 2012 and July 2013 and have since received a minimum of 30 reviews.
For more Hotel & Resort News
You may use your Facebook account to add a comment, subject to Facebook's Terms of Service and Privacy Policy. Your Facebook information, including your name, photo & any other personal data you make public on Facebook will appear with your comment, and may be used on TravelPulse.com. Click here to learn more.LOAD FACEBOOK COMMENTS


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The super sleek unit incorporates the feature set of the PDX-2000's whilst adding Torque Simulator adjustment, a new digital servo that allows Midi Control, and a choice of A.S.T.S or new 'S' Tone arm. This enables DJ's to match the turntable to their own unique style of DJ'ing.
"The PDX-3000 is the ultimate turntable for all types of turntablists, including the next generation of digital DJ's, with its USB connection," enthuses the MD of UK Vestax Distributor, Leisuretec Distribution. "It incorporates the new 2007 Vestax colour scheme, taking it back to black with a slick grey/black chequerboard enhancement. It's more powerful than ever, and a must try product when it hits the shops this June."
PDX-3000 SRP £419 inc VAT.
PDX-3000 MIX ('S' Tone arm) SRP £469 inc VAT
For more information, go to www.leisuretec.co.uk / www.vestax.co.uk


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Boom! Magazine
We are proud and excited to be introducing Boom! magazine, mid-Missouri's newest and soon-to-be fastest-growing quarterly print publication, to the market. Boom! magazine will be printed inside Inside Columbia Magazine on a quarterly basis. As its name suggests, Boom! will primarily target the Baby Boomer generation, an audience that represents 40% of all active consumers. This highly affluent demographic controls 70% of all disposable income in the U.S., outspending all other generations by an estimated $400 billion each year. Boom! magazine will be the first of its kind in mid-Missouri and is expected to achieve unprecedented success with both readers and advertisers alike.
In every issue
Boom! magazine will appeal to the interests of active mid-Missouri adults, including cutting-edge content on: travel, health and wellness, outdoor activities, food, wine, home and garden, community events and much more!
Learn more about our award-winning magazines
Connected to the local community, publications at Inside Columbia are targeted towards a dedicated audience who is passionate about their home town.
Each magazine serves as an information hub where local residents can learn more about events to get involved in and interesting topics in the immediate area. Through years of service in the community, Inside Columbia publications have garnered strong credibility with readers looking for advice from a respected source. Advertising in Inside Columbia publications, including Inside Columbia magazine, CEO, and Boom! will help your business stand out as a trusted brand supportive of the local community.


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Thursday, May 5, 2011
The Last Week
Friday was his 9 month pediatrician apt. I came away from it feeling like I was doing everything wrong. When she asked about what he's eating and I said he was still during purees, she was like, "No, he should be eating more solids by now, eating more of what you're eating." Oh, ok. Then we went over motor skills. He still isn't sitting up on his own. (How do you get a boy who has only wanted to run for months now to sit still?) Said his leg tone wasn't great and he should be working more on pulling himself up. Um, I thought he was doing good to be making progress toward crawling.
And, of course, he had his first ear infection.
The ear infection led to him being on amoxicillin, which led to his very first diaper blow out. All I can say is thank God we were both there to deal with it, that it didn't happen in the car, and that he wasn't bothered by it at all! Poor boy had diarrhea for the next three days. Thankfully, no more blow outs, and it seems to have gotten better yesterday.
Naturally, all of this stuff led to his skin problem acting up. That's better today, too.
The good side is, the last couple of days he's finally sat up on his own much better. We're working on pulling up and standing with me just holding his hands more. He thinks it's fun.
We're trying to use up the purees we'd already made and figure out what to feed him instead. He still loves his banana and yogurt in the mornings. I baked him a sweet potato and he likes that. Yesterday I steamed a carrot for him and he ate the whole thing. Today I'm going to try steaming some peas to go with another carrot. He ate a whole small orange the other night after we cut it into little pieces. But he had a harder time chewing up little pieces of apple. He still likes mangoes, didn't like watermelon or cantaloupe.
He still can't quite pick up food and put it into his mouth yet. Hopefully soon.
The cutest thing he does this week is his fantastic downward dog pose and instead of doing a real crawl he's doing a perfect inch worm move. I'm trying to get it on video. He's not at all phased by the word No. He's such a good natured boy who laughs with me all the time.
3 comments:
- Sarah said...
Mine also likes little bits of fresh mozzarella. Easy to chew.
Also, I still feed C a lot of stuff by spoon, it's just chunkier. So you could buy a bag of frozen broccoli, carrot, cauliflower mix, steam it, and then chop it really fine with a knife or processor. Then it's tiny bits but not puree.
Sorry if this is all common knowledge...I just remember I felt so confused at 9 mos trying to figure out how to make the transition to chunkier and chunkier.
- May 5, 2011 at 9:03 AM
- Beth said...
We tried a little bit of cheese. Not sure it wasn't hard on his digestive system, or if it was bad timing.
He didn't really like broccoli or cauliflower. We'll try those again later.
For me it's more a question of how to cook and store things so they don't go bad when he's only eating a little of it a day.
- May 5, 2011 at 9:25 AM
- Sarah said...
Oh I know, that stinks. I waste a lot, unfortunately. I microwave steam small portions, but if you do it too small you get that arcing-lightning in the microwave thing.
Mine is coo-coo for lima beans...if you cook the heck out of them, they're really soft.
- May 10, 2011 at 11:37 AM


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After confirming its impending launch at TwitchCon last month, Twitch today announced that the fully-featured Twitch streaming app for PlayStation is now live on PlayStation 4.
The PlayStation app allows users to broadcast content and watch and follow any broadcaster or game on Twitch, regardless of platform. It also includes full chat integration on PlayStation 4.
The Twitch app will launch on PS3 and PS Vita within the next two months, the latter of which can be used on PS TV.
Greatness awaits your #PS4 when you install the new Twitch app! https://t.co/WZJrLSeQ6u
— Twitch (@Twitch) October 20, 2015
The app is currently live in the Americas and will roll out to other regions "shortly." Live countries include the U.S., Canada, Argentina, Brazil, Chile, Colombia, Mexico, Peru, Bolivia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Nicaragua, Panama, Paraguay, and Uruguay.
Jenna Pitcher is a freelance journalist writing for IGN. You can follow her on Twitter.


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In most cases of poor vision, the symptoms manifest themselves very gradually. As such we are taken unaware and get accustomed to bad eyesight. We try to accomplish our everyday tasks without realizing that we are not seeing as clearly as we are supposed to. With this bane of blurry vision, comes along many faux pas in our daily lives. While they may seem funny, the serious implications are very real.
Let's take a look :
Difficulty In Reading:
If you are struggling to read books, newspapers or even your Facebook news feed, then you might have fallen victim to poor vision.
Headaches After TV/Movies:
Getting headaches after watching your favourite show? Poor vision can also come in between you and TV shows and movies. TV watching becomes challenging when you are not able to see clearly.
Can't Read The Signs?
Not having visual clarity while outside can lead to many embarrassing or inconvenient moments. Poor vision can lead to a missed ride, missing your stop, or even failing to recognize your acquaintance on the streets.
More Accidents, Albeit Small Ones!
Poor vision might be behind why you missed a step going down the stairs, or why you didn't see the road bump while driving your car. Spilling your coffee because you tripped, walking into a transparent glass door, stepping into a puddle of water – these are all hilarious consequences that can happen because of blurry eyesight.
Falling Behind In School Is Not Cool!
Academics is perhaps the area most affected by poor vision. Often young children or adolescents who are affected by poor vision start lagging behind in their school work. Because of their blurry eyesight, they are not able to follow what the teacher is demonstrating on the board or on the screen. Their attention in the classroom might falter and their academic performance might also suffer because of blurry vision.
Missed The Catch?
Another difficulty that people face when struggling with bad eyesight is difficulty in sports activities. Almost all sports like, cricket, football, tennis, table tennis, basketball etc, require excellent hand-eye coordination. Even swimming can become quite a challenge without good eyesight. Athletic individuals suffering from poor vision will struggle to keep up on the field with their counterparts who have clear vision.
Stress At Work And Strain on Eyes?
When we try to focus on our work with poor vision, especially on laptops, tablets and smartphones, it exacerbates the strain on our eyes. Your eyes are already struggling to see clearly. The harsh blue light rays being emitted by these digital devices just increases the stress on your eyes and can cause itchy and sore eyes and headaches.Poor vision can have many such effects on your life, where you struggle with completing regular tasks like reading, writing, or even walking down the road. If unchecked, it can have some less than funny consequences. Therefore, it is vital that we get our eyes tested regularly, at least once a year. At Vision Express we conduct comprehensive 6-step eye tests, free of cost. We also provide a variety of vision correction solutions. Book an appointment at any of our 150+ stores all over India. To book an eye test visit https://visionexpress.in/book-free-eye-test


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This plant-based blueberry crisp is for all of you gluten-free, plant-based people who are sick and tired of sorbet for dessert! Finally, an answer!
Oil-free, naturally gluten-free, this plant-based blueberry crisp doesn't use any refined sugar, and is packed with antioxidants. Best part is, it's both sweet and healthy! So don't limit yourself to just one helping.
7 cups fresh or frozen blueberries
2 cups oats (GF optional)
1 lemon (juice and zest)
1 cup maple syrup or agave
1 ½ teaspoons sea salt
1 cup sliced almonds
2 TBS flax seed
4 TBS cinnamon
½ cup of water
By Caroline DiNicola Fawley