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The signal transduction pathway or pathways linking extracellular signals to myogenesis are poorly defined. Upon mitogen withdrawal from C2C12 myoblasts, the mitogen-activated protein kinase (MAPK) p42Erk2 is inactivated concomitant with up-regulation of muscle-specific genes. Overexpression of MAPK phosphatase-1 (MKP-1) inhibited p42Erk2 activity and was sufficient to relieve the inhibitory effects of mitogens on muscle-specific gene expression. Later during myogenesis, endogenous expression of MKP-1 decreased. MKP-1 overexpression during differentiation prevented myotube formation despite appropriate expression of myosin heavy chain. This indicates that muscle-specific gene expression is necessary but not sufficient to commit differentiated myocytes to myotubes and suggests a function for the MAPKs during the early and late stages of skeletal muscle differentiation.
↵* To whom correspondence should be addressed. E-mail: tonks{at}cshl.org

subset: commoncrawl


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Europe's public sector film financiers got yet another skewering yesterday at the Triple Agent press conference, which was attended by actress Katerina Didaskalou .
Long-time Eric Rohmer producer Francoise Etchegaray explained that the veteran French director's films are no longer finance-able in his native country.
The Euros 5m indoor thriller had been made without support from France's National Film Centre (CNC) and was refused by other bodies including European cultural broadcaster Arte.
France's Avances-sur-Recettes support scheme for art films also turned down the film and, worried that it was too literary, asked 84 year-old Rohmer for further written statements as to how he intended to bring it to the screen.
"We had to turn to foreign finance to make the film. Thank goodness Rohmer is France's most exported director," said Etchegaray, who finally structured Triple Agent as a five way co-production involving France, Italy, Spain, Greece and Russia.
"The Avances-sur-Recettes should be kept for people like Claude Berri and Jean-Jacques Annaud who really need it," she said with undisguised irony.


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Pictures of Kate Middleton at the 2012 London Olympics: See What the Duchess Has Worn So Far
Snoop Kate Middleton's Entire Olympics Wardrobe, Day-By-Day!
Snoop Kate Middleton's Entire Olympics Wardrobe, Day-By-Day!
Confession time; we've been a little more interested in keeping track of Kate Middleton's Olympic outfits rather than the Aussie medal tally. But, really, can you blame us when HRH consistently looks so chic, day after day? Catherine always looks immaculate, but it's the way that she's combined patriotism and style that's made us sit up and take note. Her simple tricks? Take Princess-perfect staples like ladylike day-dresses and tailored blazers in a Brit-approved colour palette of blue, red and white, throw in some Kate-classics like skinny J Brand jeans, streamlined clutch bags and an espadrille or two, then finish with the royal blow-dry. Voila! An essay in how to support the country in style. Step inside to snoops Kate's Olympic wardrobe, from her nifty tennis whites through 'til this morning's closing ceremony extravaganza (for which she went for high street chic in a Whistles dress), we don't what's cuter — her logo-ed polos or her "C'mon Team GB" face!


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Sensoray 2960 "Dragon" is a compact, lightweight board that serves as a foundational building block in HD/SD video and audio processing systems. Packed into its tiny footprint is a powerful audio/video processing engine with controller and stream router, SD card interface, six GPIOs, and USB (device or host mode), Ethernet, serial COM and I²C communication interfaces. It has one input and one output for HD/SD digital video, a stereo digital audio input and output, and a composite NTSC/PAL output.
Audio/Video Processing Engine
Model: 2960


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A special Grow Vantage session on August 21st on Funding
Jean Leggett (Grow Vantage 30) and her husband Blair have raised over $300, 000 in funding to fuel the development of their company, One More Story Games. She has a special bird's eye view on funding a start-up business from the beginning. Hear about their personal experience and the lessons they learned to help you navigate a sometimes mystifying quest:
She will talk about:
- What they started with – what they were willing to leverage, and their personal investment
- When friends and family came onboard – the beginning of crafting that pitch letter, how they handle that with lawyers, communication with investors
- The challenges of building a biz with other people's money
- Accessing government funds – the challenges and the successes
- Going through and using Research Innovation Centres like ventureLAB, Henry Bernick, Communitech – what the highlights were and where they drop the ball
- How mentors can effectively help your business
- Building an effective brand for yourself and your business
- "What I wish I knew sooner" – the "fastest path to cash" strategies
Register now for this unique look into the world of funding. A snack will be provided. https://www.growvantage.com/events/funding-your-business/
Location: Suite Success at ESS Direct, 411 Huronia Road (at Big Bay Point)
Timing: 7:00 pm – 9:00 pm
Nibbles will be provided
Fees: $8.85 + HST
- Xcelerate Summit – Early Bird ends next week, VIP Box and Possible Virtual Trade show? - September 18, 2020
- Counselling Services for two women (special rate) - September 18, 2020
- IMMUNOCAL AND YOUR IMMUNE SYSTEM - September 17, 2020


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The fear of the apocalypse is nothing new. From the infamous Y2K bug to the Mayan doomsday prophecy of 2012, people have spent a lot of time worrying about the end of the world as we know it. For many, this anxiety has only been amplified by recent events, as devastating hurricanes have struck the Americas and tension rises in U.S. politics– and in preparation for the next potentially apocalyptic event, people are turning to Maine for shelter. Sales of so-called "doomsday bunkers" near the coast of Maine have soared in the past few months, providing preppers with an underground safe house in which they can ride out the end of the world. Ron Hubbard, owner of the Atlas Survival Shelters company, reflected on the phenomenon in an interview with ABC News.
"It's strictly defensive," Hubbard said to ABC News. "Nobody's looking for a fight. A shelter is more secretive than a bank account."
According to Hubbard, the election of Trump as president and the subsequent turmoil within the American government has been the main motivator behind many of his clients' purchases "They are afraid of the U.S. government and where this country is headed. They see a battle in the future. They see the Constitution being trampled. They see the first Amendment gone, they see the second Amendment gone…. The U.S. Constitution is under attack." This sentiment is echoed by Gary Lynch, owner of a bunker installation company in Texas.
"Basically, people are afraid of nuclear bombing," said Lynch in an interview with Haaretz. "They know as long as Iran, China, or Russia threaten us, Trump won't back down. And they are afraid that if we most likely go to war, nukes will be used."
Here in Maine, Frank Woodworth claimed in the Bangor Daily News that he is "as busy as the dickens" with orders for his bunker installation company, Northeast Bunkers.
"We've seen an increase in sales recently…. with North Korea's talk about then doing missile tests," said Woodworth in an interview with Bangor Daily News. "Generally speaking, we have higher sales with these types of events."
Doomsday bunkers are typically made of steel and buried three to four feet underground, with a doorway that is typically camouflaged using trees and brush.
"With [the bunkers], you have a sense that you're invisible because nobody can get to you down there," said Hubbard to the Bangor Daily News. "You can drive within 20 feet of a bunker and not know it's there."
According to the Northeast Bunkers website, the shelters usually cost between $40,000 and $60,000. The company offers a range of sizes, from 8×13 feet to 8×20 feet, and can also install fully functional kitchens, septic systems, running water, and more. Some wealthy clients even purchase bunkers with hot tubs or screening rooms, challenging the stereotypical image of barren, concrete shelters. Robert Vicino, CEO of Vivos, claims that for many, this type of luxury is necessary for survival.
"Your father or grandfather's bunker was not very comfortable," Vicino told CNN in an interview. "They were gray. They were metal, like a ship or something military. And the truth is man cannot survive long term in such a Spartan, bleak environment."
Many celebrities have hopped on the luxury bunker train, constructing expansive and expensive underground safe houses in preparation for the worst. According to an article by The Daily Mail, Bill Gates is reported to be creating a nuclear bunker under his Seattle property, and Kanye West admitted that he placed an order for a luxurious bunker for himself and his family. The U.S. government is also reported by The Daily Mail to have an extensive network of bunkers all across the country, sparing no expense to make sure that the government will be protected from doomsday in whatever form it takes. However, many people of more modest means order bunkers as well. Margaret, a retired schoolteacher from Farmington, ME, has her own way of making her shelter feel a little cozier without going bankrupt.
"I have decorated it with family portraits and other things from around our home," said Margaret in an email to Bangor Daily News. "It feels really good when we go inside. Like home." While hanging family portraits or installing a Jacuzzi in an apocalypse bunker may seem a bit ridiculous, sometimes it's these little things that can make a situation feel so much better– and if these doomsday preppers are confronting nuclear war or economic collapse or whatever else ends the world as we know it, they will need all the help they can get.


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DHAKA: Two Bangladeshi nationals sheltering outside a Kolkata police traffic outpost to escape the rain, were crushed to death on Saturday (August 17), when a Jaguar car rammed into them after hitting a Mercedes sedan, reports NDTV.
The victims have been identified as Kazi Md Mainul Alam, 35 and Farhana Islam Tania, 28.
The driver of the Jaguar -- a 22-year-old man from a prominent Kolkata family-- reportedly fled the spot but was later arrested.
The crash took place at 1:50am in the vicinity of Kolkata's famous Park Street.
The accused, who was allegedly speeding down Shakespeare Sarani also known as Theatre Road, crashed into a Mercedes Benz car at the Loudon Street crossing. Both the luxury vehicles spun out of control and the Jaguar rammed the victims standing nearby.
A third Bangladeshi national --who escaped being hit by the car-- said the couple was crushed against the wall of the police outpost. They had come to Kolkata from Dhaka for the woman's medical treatment. They had gone to a restaurant for dinner and were trying to get a taxi to return to their hotel when the accident took place.
They were taken to a Kolkata hospital, where they were declared dead on arrival.
The Jaguar driver--Arsalan Parvez-- allegedly fled the accident site. The driver and the passenger of the Mercedes also got injured.
The accused belongs to a well-know Kolkata family which runs a popular restaurant chain - Arsalan. He is a student at Edinburgh and was home for holidays.


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Episode 399 – Nobody Will Buy Red Dead
Stewart Gilray from Just Add Water joins Glenn and Josh. New Releases, Gravity Crash came out 5 years ago. 'Venom' coming to Zen Pinball 2. "You can't effectively test" for games like DRIVECLUB. Hacker group claims they got into the PSN. Patch coming for 'Never Alone'. What we're playing and watching. Episode 400 LIVE next Sunday. PlayStation Experience. Comedian is Steve RannazzisiRead more


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A number of recent developments have ushered the global LED work light market into a period of growth and advancement. Portable lights specifically designed to temporarily illuminate the working area at a residential premise and/or a commercial and industrial workplace and uses LED technology as a source of illumination are termed as LED work lights. According to the market estimates, the global LED Work Light market is foreseen to reach ~US$ 13 Bn by the end of the forecast period, registering ~CAGR of 3.5%. The key reason cited for the increase in the LED work light market includes swift penetration of LED technology in portable lighting solutions due to better illumination capabilities and substantial of flashlight in the market space.
The report covers a complete study of the LED Work Light market with an analysis of types of LED Work Light. The report summarizes the parent market for LED Work Light and markets, which are going to impact the growth of the LED Work Light market. It provides a brief description of how the LED Work Light market will perform in various regions around the world according to the previous performance and future potential in respective regions.
Battery-operated LED Work Light to Witness Skyrocketing Growth
As per the market consensus, there are mainly two product types available for LED work light i.e. battery-operated and plug-in LED work lights. Among these LED work lights, the battery-operated LED work light is ascertained to dominate the global market due to a range of various advantages including its application in remote areas, high portability, among others. Consumer expectations for portable and easy to use work light products also attribute to the growth of the LED work light market in the foreseeable future.
Demand for Product Efficiency Poised to Surge the Demand
The market expansion of the global LED work light market is currently confined to an extent owing to the perception among some consumers that LED work lights are expensive. Also, there exists a potential consumer segment that lacks awareness regarding the benefits of using LED lighting products. Increasing demand for energy-efficient work lights offering durability to work in more severe conditions and requiring low maintenance are primarily driving the market for LED work lights. LED work lights are preferred over other work lights as LED work lights offer higher efficiency and longer battery life.
Residential Applications Set to Fuel the Pace of LED Work Light Market
In the market assessment it was found that the adoption of LED work light has taken a significant upsurge in the market share of global residential lighting sales. LED work light sales have overtaken fluorescent sales in the residential sector, and that share is expected to continue expanding. Importantly, countries need to take advantage of recent sales trends and update their regulatory policies pertaining LED work lights.
Europe and Asia Pacific to Grow at an Unprecedented Rate
The rapid development of LED work light technology has enabled a better energy-efficient feature than traditional light sources. Being a huge producer of farm products, Europe and Asia Pacific stay ahead of the other region in terms of consumption of LED work lights. Also, application of LED work lights in agricultural lighting can efficiently increase crop yields. With an ongoing advancement in the contemporary LED work lights, it has been assessed that Asia Pacific to emerge as a lucrative LED work light market. Moreover, countries are mandating standards that could eventually outlaw other high-wattage lighting solutions, thereby, attributing to the high sales of LED work lights. Additionally, OSHA's workplace lighting standards and regional regulations to avoid the usage of halogen and incandescent work lights are foreseen to bolster the demand for LED work lights.
LED Work Light Market – Competitive Landscape
Unprecedented change in the lighting industry has been substantially assessed in the report. In terms of LED Work Light market structure, it shows a perfect competitive scenario; where a large number of regional and domestic brands are operating in the market. More than 4% of the global LED Work Light market is led by top 8-10 brands/companies. Moreover, the companies in the Led work light market are adopting strategies such as product repositioning, rebranding, new geographic reach, and exploring novel applications and end-user to gain competitive-edge in an ever-growing LED work light market.
Prominent players covered in the LED Work Light market report includes -
This PMR study offers an analysis and forecast of the global LED Work Light market between 2019 and 2029. The LED Work Light market study considers 2018 as the base year, with market values estimated for 2019, and a forecast developed for the duration between 2019 and 2029. Compound Average Growth Rate (CAGR) has been represented from 2019 to 2029. The study covers various perspectives of the global LED Work Light market, including market dynamics, value chain, pricing analysis, competition analysis, regional, and segmental growth comparison, and macro-economic along with segment level projections in a comprehensive manner.
This Persistence Market Research report carefully analyzes the LED Work Light market at a global and regional level, through market segmentation on the basis of key parameters such as product type, material type, vehicle type, wheel type, and sales channel. The primary objective of the report is to offer key insights on market updates, competition positioning, growth rates, and other relevant information, and statistics in a suitable manner to the readers or various stakeholders in the LED Work Light market. Subsequently, the study aims to analyze the most recent trends, dynamics, and potential strategies in the global LED Work Light market.
The report is structured to allow readers to develop a thorough understanding of the LED Work Light market. It begins with market definitions, which are followed by the market background, market dynamics, and market analysis by key segments, regional analysis, and competition landscape. Each section covers a qualitative and quantitative assessment of the LED Work Light market on the basis of facts, historical developments, and key opinions collected from industry participants through dedicated interviews and trends in the LED Work Light market.
LED Work Light Market: Segmentation
By Product
By Operation
By Sales Channel
By End Use
By Region
Subsequent sections of the report provide value (US$ Mn) and volume ('000 units) projections for the LED Work Light market on the basis of the aforementioned segments at a global level.
The global LED Work Light market values represented in these section have been agglomerated by collecting data and information at a regional level. The LED Work Light market information, along with key facts and insights, covers unique analysis frameworks such as absolute $ opportunity analysis, year-on-year growth trend comparison, market share, and attractiveness analysis for each of the sub-types covered in each segment of this LED Work Light market report.
The next section of the report presents a summarized view of the global LED Work Light market based on eight prominent regions considered in the study. The section includes regional market position, growth potential, trends, and attractiveness analysis for each of these regions.
All the above sections evaluate the present market scenario and growth prospects in the global LED Work Light market, while the forecast presented in these sections assesses the market size in terms of volume and value.
In order to offer an accurate forecast, we started by sizing the current market, which forms the basis of how the global LED Work Light market is expected to develop in the future. Given the characteristics of the LED Work Light market, we triangulated the outcome of three different types of analysis: primary research, secondary research, and our own analysis. However, forecasting the market in terms of various segments and regions is more a matter of quantifying expectations and identifying opportunities rather than rationalizing them after the completion of the forecast exercise.
All the LED Work Light market segments and sub-segments have been analysed on Basis Point Share (BPS) to understand each individual segment's relative contribution to the LED Work Light market growth. Another key feature of the LED Work Light market report is the analysis of all the key segments in the LED Work Light market, sub-segments, and regional adoption and revenue forecast in terms of absolute dollar opportunity. This is traditionally overlooked while forecasting the market; however, absolute dollar opportunity is critical in assessing the level of opportunity that a provider can look to achieve, as well as to identify potential resources from a sales and delivery perspective in the LED Work Light market.
In the final section of the LED Work Light market report, a competitive landscape of the LED Work Light market has been included to provide report audiences with a dashboard view categorized on the basis of providers present in the value chain, their presence in the LED Work Light market, and key differentiating factors and strategies. This section is primarily designed to provide clients with an objective and detailed comparative assessment of the key providers specific to a market segment in the value chain of the LED Work Light market. Report audiences can gain segment-specific vendor insights to identify and evaluate key competitors on the basis of the in-depth assessment of their capabilities and success in the LED Work Light marketplace. Detailed profiles of the providers have also been included under the scope of the report to evaluate their long- and short-term strategies, key offerings, and recent developments in the LED Work Light market.
Company Profiles:
Led Work Lights Market


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Hebridean Crofts by Ron Lawson
£276.00 – £375.00
SKU: 10000949 Category: Ron Lawson Tags: Ron Lawson, Ron Lawson Hebridean Croft
Born at home on a farm in Mid Lothian in 1960, Ron spent his early years enjoying the open spaces of the Scottish countryside.On leaving school at 16 Ron started work in the art studio of DC Thomson in Dundee. It was here, while working alongside many talented artists, that Ron was encouraged to develop his watercolour skills. After 35 years Ron left the publishing firm to devote more time to painting and embark on a career as a full time artist.Mixing a lifelong love of cycling with a desire to capture the beauty of the Highlands and Islands of Scotland. Ron now explores these areas by bicycle with his sketchpad and paints. By contrasting vast, intense, brooding skies with his signature white crofter's cottages in the foreground Ron's paintings celebrate the wild remoteness, peace and simplicity of rural Scotland.
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If you happen to're new to the world of internet design, then designing a website for enterprise or private reasons would possibly seem to be a frightening task. We associate with the most effectively-identified area providers in the UK so you can find the perfect area (URL) for your site – and you can buy and manage it inside your web site builder. GoCentral Web site Builder robotically reviews your web site and optimizes it for serps like Google®, Yahoo!® and Bing®. For certain you'll have to make investments time into creating your own content material and setting things up. However the days when solely super tech geniuses could make web sites are long gone.
It's a very personal alternative when it comes to which builder interface you favor, so investing a little bit of time in testing them out is well value it. Other builders offer extra freedom; if that is what you are looking for, take a look at Wix. BTW I don't necessarily want the best builder, I do some tech work; just a skilled trying, free resolution with our own area cause my Dad will not spend a dime on this until I make him see the benefits.
You will often see web site builder adverts from corporations like GoDaddy or Wix. GoCentral Website Builder uses the design of your web site to mechanically create eye-catching emails that will not end up within the Spam folder. The website builders talked about above are most likely not equipped for the unique requirements that a domain title registrar want with a view to run its enterprise properly.
If you wish to build a business website, I'd begin with trying out a number of website builders which can be appropriate for businesses here. Effectively-recognized site builders like Squarespace, Weebly, and Wix are always bettering. Competitively priced and offering much identical service as lots of the bigger names of net builders. Thanks to our revolutionary drag & drop website builder, you possibly can create an internet site just the way you need it. Simply click on the content material you want to change, or drag and drop new photographs.
Grow your online business with knowledgeable on-line store. I don't assume WYSIWIG website builders have any inbuilt searchable databases – at the least not those I've used before anyway. The better website builders, like Wix and Duda, offer a market of third-social gathering widgets, for things like types, chat, reservations, and social feeds. With our design templates and have-rich Web Apps you might have the whole lot you want to create a web site that performs nicely – with no professional information crucial.


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You're Busy, Or You're Nobody
It seems like society often uses being busy as a measure of success. I suppose it kind of makes sense because if you are busy, it is probably because you are in high demand. If you are in high demand, it is likely because you are good at what you do. And if you are good at what you do, you are probably successful. While on the surface this seems like a valid argument, I believe that this premise of busyness being a marker of success leads a lot of professionals to prioritize being busy for busy's sake. It has created a generation of people who are so stressed about both being and appearing busy that they really don't get much done.
Think about it, we have all had those weeks where we sit down and look at our calendar and suddenly feel so overwhelmed that we cannot think about our to do list for the day, never mind our board meeting tonight, or the networking event tomorrow. Sometimes weeks like that just happen, you cannot help how the stars aligned. However, often times this is our own doing. I often have overscheduled weeks and I know that it is my own fault. I've decided I am making a conscious effort to make my schedule less busy. When we overschedule and overcommit ourselves, we run the risk of not doing a very good job at any of the things we set out to do. So here are my tips for how and why you can and should embrace not being busy. I promise, not being busy will not make you less successful, it will make you your best self.
1. Set your priorities. What is it you want to accomplish this week, this month, this quarter, this year? Make strategic and thoughtful choices about what you want to get done and how to get there. Warning, you will have to say no to things, but this is good. People who say they are too busy are a pet peeve of mine. We are all too busy to accomplish everything which is why we must prioritize. Being too busy is not the actual issue, the truth is you cannot or choose not to prioritize a certain project so just be honest. Not everything can or should be a priority.
2. When planning your projects outside of work focus on one or two projects and dive deep. We are all at that age where volunteering and board membership are important for our professional development. I urge you to be strategic about which organizations you get involved with. Do you know that you are committed to this organization? Do you know you will make a positive contribution to the organization? Do you have the time and resources to join the board? Ask yourself those questions and commit to making a strong impression on one or two organizations. Again, you will have to say no to certain opportunities, or choose to make a limited commitment but you will have a greater impact on the organizations you serve.
3. Plan unstructured free time. Having open space on your calendar allows you to recharge, reflect, and gives you the opportunity to say yes to things that you would not normally be available to do. Stop thinking about what you have to do next and enjoy the moment. I struggle with this, I hate downtime, but I am really working on putting blank space on my calendar because having this time allows me to be more productive overall.
4. Schedule open thought time. This is like unstructured free time, but at work. I am sure there are times my coworkers walk by my desk and think that I am doing nothing, just staring out the window with a notepad in my hand. This is time for your brain to recharge and wander. It allows new and creative ideas to float to the surface instead of being trapped by your to do list.
5. Find something you love to do and prioritize scheduling that activity. We all have at least one activity that helps us deal with stress, an activity that leaves us feeling both at peace and energized. For me, it is working out. No matter how busy I am, I need to get a workout in. In fact, the busier I am the more I need to make sure I get to the gym. Even when I do not want to get up at 6:00 am, I feel like I can take on the world after a short run. What is the activity that leaves you feeling empowered and confident? Make that activity sacred and do your best to make sure it's one of the few things that you do multiple times a week.
About the Author
Stephenie Lazarus is the Development Director at Providence Englewood Charter School. Formerly, Stephanie was the Development Manager at LIFT, a nonprofit working to help Chicagoans lift themselves out of poverty for good. Stephenie is a graduate of both University of Michigan and University of Chicago and volunteers her time with Erie Neighborhood House's TEAM program and the Junior League of Chicago.


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Wuest is a senior sales executive who brings 30 years of experience selling technology and enterprise software solutions. Wuest will lead the sales team for the OspreyData AI software solutions in Energy. Previously, he led SAP teams in Business Intelligence and Oil and Gas, and in Business Applications at Oracle, and other technology firms. Richard helps executives, IT, engineering and field organizations document the ROI of automating processes and make successful digital transformations in Oil and Gas.
Richard attended Texas Tech University and graduated with a degree in Finance. Richard will spend a great deal of time in the field, helping clients streamline production processes, and introducing OspreyData to the market.
"OspreyData is pleased to have Richard lead our sales initiatives, focused on production optimization and leveraging our artificial intelligence enabled platform, used by Oil and Gas producers to lower lease operating expenses and enhance oil production," stated Ed Cowsar, CEO. "His leadership and success help us add OspreyData clients who need continued oil and gas production growth while lowering costs."
OspreyData also announces that Alex Lamb has joined as a Data Scientist. Lamb brings a wealth of knowledge and experience to our team. He was President of the Texas Geophysical Society at University of Texas at Austin, where he obtained a Master of Science in Geophysics from the Jackson School of Geoscience, and he also has a Bachelor of Science in Physics and Information & Computer Science from University of California Irvine. He has deep experience as a geophysicist at independent oil and gas companies including Devon Energy in Oklahoma City, working on rock physics modeling, seismic inversion, AI predictive models and reservoir characterization integrating multiphysics datasets with engineering to optimize well placement, completions parameters, and reservoir production. Lamb spoke at recent industry conferences including the URTeC Conference in Denver and at American Association of Petroleum Geologists on "Depositional Interpretation and Sequence Stratigraphic Control on Reservoir Quality and Distribution in the Meramec STACK Play: Anadarko Basin, Oklahoma." At Osprey he will be applying machine learning techniques to production optimization and artificial lift problems for oil and gas clients.
Ed Cowsar stated, "We are honored that Alex, a very experienced Data Scientist and proven Oil and Gas Geophysicist, has joined our growing software company. OspreyData increased 2019 investments in oil & gas experience, AI technology, and platform capabilities."
Global oil producers and independent oil companies alike are seeing more value in the OspreyData AI enabled Production Optimization Platform. New clients are using OspreyData's cloud-based software across the Permian Basin and other shale plays to scale growth, lower Lease Operating Expense, and increase production. OspreyData's incremental software implementation offers immediate value. And as oil and gas prices fluctuate, we help agile E&P companies win in this merger and acquisition market on Wall Street, and in their savvy acquisition and divestiture of leases in the oil fields. "
OspreyData is hosting another Oil and Gas Production Optimization Series webcast on Thursday July 18th, 2019 at 9:00 AM Central. You can register now for OspreyData's upcoming webcast, featuring Richard Wuest and Venkat Putcha, PhD, PE, "The Top 3 Reasons It's Time to Automate Gas Lift Optimization"; register here now for this informative session.
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For more info visit www.ospreydata.com or contact Tim Burke, VP of Operations, to schedule a full press briefing at (844) OSPREY-NOW.


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Mental Health/Journal Notes/Slice of Life
by: Sheri de Grom
Notes From My Journal – Monterey, California
Late 1990s
My office on Fort Ord was quieter than usual: no laughter, chatter or copy machines running. Usually the investigators bantered with each other and the phones never stopped ringing. When had the silence settled in? Had another day passed me by?
Glancing up from my stack of folders, I saw Mike, my deputy, standing in my office doorway. He hadn't made a sound; one of his unique qualities that always amazed me. I marvel at his ability to hold one pose motionless for hours on end. He'd told me it was a talent he'd honed along with his sharpshooter skills. He'd never shared with me exactly when he'd needed that expertise and I hadn't asked. We'd shared the shooting range often enough to know that we could cover each other with confidence.
"Hey you, how long have you been standing there?"
"Long enough to know that we both have to get out of here. It's almost nine-thirty and I heard you tell Cecelia [editorial note – my secretary] earlier that you were still going to the hospital tonight. I know for a fact that you haven't had anything to eat in several hours, if at all today."
Leave it to Mike to call it the way he saw it.
"And what have you eaten today?"
"Remember, I had that delicious lunch at the nursing home." His body tensed and his hand grazed his belt as if the memory were physically painful. "I hope I live long enough on their food to finish the investigation."
"We've seen the winning results of those meals haven't we?" Mike went on to tell me how the patients' lunches had consisted of chili dogs, potato chips, cooked cabbage and peaches in heavy syrup. Every tray the same. No allowances were made for diabetic or other medical nutritive needs and the high sodium content alone made the entire meal unacceptable. The indigestible component of the food for the patient population being served broke every rule.
Nursing home fraud routinely uncovers massive irregularities concerning patient nutrition. Thousands of dollars are saved annually by ignoring Federal guidelines.
We'd started our investigation as a Veterans Affairs fraud case but fraud opened up wherever we turned at the nursing home. We had no idea where this case was taking us, but it wasn't going to be pretty. Every item we examined revealed additional improprieties.
"What do you say boss, let's get out of here and go grab dinner."
"I'd love to but I really must go the hospital." The internist promised she'd keep me informed, but that's not enough. How can I say Tom is my top priority when I'd admitted him that morning and hadn't visited or called all day?
Suddenly I felt weird, the all-too familiar and uncontrollable perspiration running from every pore, and makeup slithering down my face. My hair was oily and wet and so was every inch of my body. Did I smell? My clothes stuck to me.
I couldn't pull enough air into my lungs, my breath quickened but air came raw into my throat. Suffocating. There was that sensation of a trapdoor suddenly opening in my belly. Oh, God. Please don't let me soil myself. My heart wanted to jump out of my chest . . . I was sure it could . . . it would . . . that was my heartbeat roaring in my ears, wasn't it? It was uncomfortable to swallow; the perspiration intolerable.
I'd always worked hard to maintain my image—a professional woman. Could this be God's way of saying, the joke's on you? Was it my fault that Tom suffered?
My hands tingled and then they didn't. Why couldn't I feel anything? Had I lost touch with reality?
"Sheri, Sheri . . . can you hear me . . . it's Mike. You're here with me and you're safe."
I felt a hand on my arm and jerked.
"Don't touch me. I feel so grungy." I cringed. "I'll never be clean. I need a shower."
My legs folded under me. I wanted to stand, but couldn't. Touching my lips, the tips of my fingers were wet. Blood. I'd bitten my lips so hard they bled.
"Sheri, breathe. Come on, deep breaths. Follow me. In-out. That's it, now repeat. Over and over."
I was calming down. My heartbeat was slowing. But I was still covered in sweat. The worst feeling ever.
I lay on my office floor; how could I compose myself after what had just happened? Even more puzzling, what had just happened?
Mike bent down and supported me while I stood up.
"Boss lady, you've given me one hell of a scare. We're not going to do whatever that was again. I'm going to play Dr. Mike for the duration of the VA case plus all the other stuff you have going. You need a good meal and a way to blow off steam so you can focus on whatever you think you must do."
"That's quite a speech, partner."
"Indeed it is. Now, if you like, you mentioned feeling dirty. I don't see you that way but if you insist, I'll give you time for a shower before we eat. However, don't plan on my being so lenient in the future."
"Yes, sir. Might I ask who made you the boss of me?"
"I thought that was pretty obvious. You asked God for help and I'm here. You know, our Lord does work in mysterious ways."
"Don't be a smart-ass."
But in my mind, I was thanking God for this particular smart-ass.
"Go get your shower and no you don't have time for makeup and all that girly stuff. I'll pop us a couple potatoes in the microwave while you're doing your thing."
Standing on tiptoe and leaning in, I warned, "Don't you touch me."
Mike's mischievous grin and flashing blue eyes were music to my seriously bruised and battered heart; I planted a kiss on his forehead.
One of the best features of having our offices in an old WWII barracks building was that plumbing was in place. No one had ever thought to take out the toilet and shower between each office. My theory was simple. I was a workaholic and I wanted some comforts of home. My shower connected to my office; how convenient is that?
I didn't know what had happened to me earlier but I did know that I'd lost it and was sure that it was a result of trying to hold everything together and pretend I was coping, when in fact, I was falling apart.
I was sacrificing myself for everyone else and I didn't need anyone telling me how that would turn out if I kept up my current pace.
Clean skin, clean hair . . . nothing in the entire world felt better . . . wel . l . l . not unless I could slip into a bed with crisp, clean sheets with Tom. But, that was a fantasy.
Pulling on favorite faded jeans and an old familiar flannel shirt brought a smile to my heart.
Lord, it was good to touch something as simple as a well-loved flannel shirt and have it fill my heart with pleasure.
I found a pair of socks to match my shirt and padded without shoes into Mike's office.
"Wow, you've gone all out."
His office had become a quiet library setting. He'd moved his lamps to softly accent the walls of books. They cast a glow across his leather-bound collector editions with their scripted gold lettering along the spine, soft jazz played in the background.
"This is wonderful. You've even rolled your sleeves exactly the way I love them."
The staff was always teasing us about my preference for the sexy way Mike had of rolling up his sleeves. He had a special way of doing them that was a real turn-on, to me anyway. Tom had tried to duplicate Mike's method numerous times and had even tried to get Mike to demonstrate his skill. Mike liked to tell Tom that it was the only thing he could do better than him and he wasn't about to give away his one winner.
"This is so good and so much better than going out."
"I agree."
We'd laughed often calling the refrigerator in our personal supply closet our best secret weapon, and tonight it was proving itself just that. He'd prepared a wonderful assortment of the goodies that Cecelia kept stocked for us.
In the hour that followed, the conversation flowed easily. Mike exuded confidence and charisma. From time to time he allowed a smile into his voice as he shared his concern about how hard I was pushing myself. Those sharp, clear eyes of his told me he knew he was right on target. He'd seen me move into meltdown mode less than two hours ago.
"Thanks for dinner but I absolutely must get to the hospital. I can't go home until I see Tom."
"Why don't you let me drive you to the hospital? I worry about you when you're so tired."
"Thanks, I appreciate the offer. But, I can make it on my own tonight. Thanks for the wonderful dinner and I'll see you tomorrow." I remembered a song we'd tagged as ours and laughed, "By the way, I've Had The Time Of My Life. I always do."
ADDED NOTE: I have no idea how I would have had a successful career if I hadn't surrounded myself with highly-motivated people who have become friends for life. During the many years we worked together as a team, I often thought they knew me better than I knew myself.
Names have been changed but my heart sings when I remember my friend, 'Mike.'
How about you, have friends held you up when otherwise you might have fallen apart?
I've had many panic attacks like the one I describe in this blog. In my situation, they are triggered by my PTSD.
Thank you for reading with me.


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For Nicole Kidman, having her mum Janelle with her on the red carpet for Wednesday's AACTA Awards – the Oscar winner's second Sydney gala in a week – was everything.
"It's so nice. There she is," Kidman told The New Daily, pointing out Janelle and her other plus one, niece Lucia Hawley.
"She's the reason I'm an actor, so it's very appropriate that she's here."
Kidman's brilliantly boho Valentino gown was easily the standout (perhaps only) couture look at the ceremony at Sydney's The Star. Her burst of colour was a high point in a night where black played a starring role.
Worn with silver sandals and featuring velvet, sheer panels and sequin swan and butterfly embellishments, Kidman's dress was both a super modern triumph and something Samantha's mum would have worn on 1970s series Bewitched for a patio party.
Comedian and actor Celia Pacquola was slightly nervous about the dress code and level of glamour required: "It's not our sort of area. We're more comfortable in pubs, doing stand-up in front of 12 people."
Back in Australia for the premiere of upcoming series Bloom, Phoebe Tonkin – who slayed in sexy Parisian stripes and classic red lipstick – prepared for the night by "just relaxing", she told The New Daily.
"I wish I'd gone for a swim in the morning, but I couldn't get to it. My mum was over and we sat eating carob bars."
Angourie Rice – who was "fangirling" over Pacquola – had one day to pick her dress, and went for pink Gucci. "I feel like a princess," she said.
Sarah Snook told The New Daily she worked with stylist Stacey O'Connor to choose her pale mint Viktoria & Woods plunging pantsuit. "I'm really interested in more sustainable and ethically responsible fashion," she said.
Deborah Mailman went regal in gold satin with shawl collar with chandelier earrings.
Nicole Da Silva was mostly business, a little bit party, in a flared black pantsuit.
Tasma Walton went a touch Halloween, a touch ice dancer in a ballgown with licking flame motifs.
Leah Purcell also took the classy route, pairing back a fancy floor-length skirt with classic white shirt.
Susie Porter! Glamour personified and proof shoulder ruffles are a girl's best friend if you can't afford diamonds.
Julia Zemiro rocked up in skinny pants and a double-breasted blazer with undone hair. Chic.
E! Australia host Ksenija Lukich was simple and fabulous in a strapless white dress with festive earrings and sandals made from tape measures.
The Obscure actor Kate Cheel was anything but, bringing the drama in a black gown with plunging neckline and swirling tulle skirt.
Simone Kessell (The Crossing) teamed sexy modern Grecian with kinda dated hair.
Isabel Lucas was super modern and retro at the same time, harking back to the 1940s with a head scarf, fitted dress and foxy Mary Janes.
In a mash-up of ringmaster and turn-of-the-century sailor attire, Kerri-Anne Kennerley was bold and flashy. As usual. Thank you fashion god.
Rebecca Gibney also walked on the dark side, channelling a 1980s Joan Collins.
Dear Emma Leonard: Loved the colour, liked the length but something about the bodice (I know, but it has one) looked a teeny bit homemade.
Was she auditioning for a Maleficent stage show? Melina Vidler was all sharp angles, cutaways, shiny surfaces. Needed softer hair.
Gracie Otto was cool. Maybe too casual. But cool.
Jackie Gillies looked rapt, and wrapped in a mid-range curtain.
Marta Dusseldorp did slinky European style with plain dress, statement earrings and clutch.
Celia Massingham: Seriously ethereal. Age appropriate and beautiful.
Sigrid Thornton went showbiz to the hilt. Come to the cabaret!
Shaynna Blaze threw everything at this. Including possibly the kitchen sink hidden under the Darrell Lea bow and ruffles.
Couples goals: Bryan Brown and Rachel Ward. Looked like they could just as easily have been dropping by a suburban solicitor to sign some papers. Effortlessly stylish.
With reporting by Matilda Dixon-Smith


text: Three Simple Secrets to B2B Lead Gen Success in 2015 It's no secret that the popularity of email marketing continues to surge. Email remains the number one channel of choice for marketers worldwide, with a recent survey reporting that 60% of executives say it's their leading ROI generator hands down. But to get the results you want, you've got to get it right. So what are the top things to keep in mind as you rely upon your go-to lead generation tool once again in 2015? First off, it's important to understand that even though a host of shiny new objects have made their way into the workplace, email stands out as the most critical productivity tool in business today. In fact, a Pew Research study indicates that 61% of workers say email is "very important" to their jobs, while the Internet ranks at 54%, landlines at 35%, mobile devices/smartphones at 24% and social networking at only 4%. So if you're targeting businesses and executives, you want to get their attention by way of the channel that matters to them most, and that is indisputably email. The next step is making sure your messages rise above the clutter in the email inboxes you're going after...and here are three key ways you can accomplish that: 1) Be Smart About Your Subject Line: Your subject line is the first and most lasting impression you can make on your audience. So what sells today? Everything from flattery, to controversy, simplicity, humor, personalization and metrics, according to this post by WordStream. Keep your subject lines brief, too. About 50 characters is ideal. Also, avoid splashy promotional phrases – they can be a turn off. And it's common knowledge that the use of the word "free" might set off a spam filter, so avoid that all costs. Lastly, always be true to your headline. Don't draw a reader into your message only to disappoint them with content that doesn't jibe with the subject line. 2) Start Clean: The quality of your email list – not the length of the list – is the biggest factor in generating the best lead gen results, experts say. Content may be king, but it's not going to drive ROI if it's not reaching the inboxes you're targeting. So make every effort to ensure quality email data to prevent bounces, blocks and more. If you're using an outside service, be sure to ask them about their specific methods for cleansing and enriching their email data. The most reputable data acquisition firms will even offer a data quality guarantee with credit back for email data that doesn't deliver as promised. 3) Make Mobile Work for You: Your targets are relying on mobile devices more than ever, so as a marketer, it's incumbent upon you to engage with them in a way that suits them while they're on the go. So make sure your email message is designed to be easily viewable in a mobile format. You'll see open rates rise as a result. And while mobile design is essential, it may also result in fewer click-throughs, which means marketers need to work harder than ever to ensure their communications have the stickiness that drives results. Using personalization and new strategies such as a trigger-based approach to email marketing, your messages are more assured of getting noticed. These tips are only the beginning when it comes to effective lead-generation results with your email marketing. What strategies have you found to have the most profound impact on ROI in your organization? ### If you think acquiring new B2B business contacts data might make a difference for your e-mail marketing efforts in 2015, you might want to give BizFACTZ a try. While most business contacts services are delivering only 50-70% data accuracy with email data, BizFACTZ consistently exceeds that amount with 90% email accuracy. Click here to find out more and use the offer code "INTRO" to receive a 20% discount on your first order. Photo credit: Copyright:  / 123RF Stock Photo


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A Future Without Malaria Possible
Malaria is currently a major concern across the continent, specifically the drug-resistant strain of malaria parasites.
"The reality is that there are resistant parasites to every known antimalarial drug," said Manuel Llinás, professor of biochemistry and molecular biology at Penn State University and lead author of the paper. "We need new drugs targeting different aspects of parasite biology."
Nearly half of the world's population lives in areas at risk of transmitting malaria, a serious and sometimes fatal disease that produces symptoms such as fevers, chills, and flu-like illness. According to the World Health Organization, over 212 million cases of malaria were reported in 2015, with an estimated 429,000 deaths, the majority of which occur in young children in sub-Saharan Africa.
After a parasite-carrying mosquito bites a person, the parasite infects liver cells, where it grows and multiplies. The parasites then invade red blood cells, where they multiply further, releasing daughter parasites, or merozoites, that in turn must invade new red blood cells. Symptoms of malaria are expressed during this cyclical 48-hour red blood cell life-stage.
The main aim in malaria prevention is to keep the parasite from invading red blood cells, which is why red blood cell invasion has been seriously considered as preventative measure for a long time. Former efforts have failed because of surface proteins. Unless every single one can be interfered with, the virus can't be blocked.
Instead of targeting surface proteins, this new drug will target a part of the virus called PfAP2-I. Preventing it from binding with the DNA and recruiting other important proteins. This would stop an infection before it even reaches the red blood phase of the infection.
South Africa has had a host of malaria incidents this year, especially in the Limpopo province.


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text: Just in case the standard Escalade doesn't quite measure up to your lifestyle, Cadillac offers the Escalade ESV. At 20 inches longer than the regular Escalade, the ESV is an enormous SUV, carrying on the tradition of Cadillac dreamboats from bygone eras. Like its tail-finned ancestors of the 1950s and 1960s, the ESV does nothing if not make a statement. Except for dimensions, the regular Escalade and the ESV don't differ by much.


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Microsoft announced on Monday that it has bought Softricity, a provider of software to virtualise applications or stream them on demand to client PCs.
Microsoft also said that a beta version of its hypervisor for the upcoming Longhorn version of Windows Server will be available by year's end. Microsoft also plans to release a beta version of Microsoft System Centre Virtual Machine Manager, formerly codenamed Carmine, within 90 days.
Microsoft said it would offer more details about it plans at its WinHEC conference, which started this Tuesday in Seattle and runs through until Thursday.
Softricity is a key purchase for Microsoft on the desktop side, according to Jim Ni, a group marketing manager with the Windows Server team. The company's virtualisation software can reduce application incompatibilities that arise, for instance, if a user running Windows Vista on their PC needs access to an application that runs only on Windows 2000 or XP. Rather than having to install the application, the user can access a hosted version on a server, Ni says.
Microsoft did not disclose how much it paid for Boston-based Softricity.
The upcoming Windows Server hypervisor, which enables servers to run multiple virtual machines with different operating systems, will be integrated with Longhorn and released to manufacturing within 180 days of Longhorn, which is expected to be released in the second half of next year, Ni says.
It will be the successor to Microsoft's current Virtual Server 2005 R2, which works with Windows Server 2003 and which Microsoft made free last month.
As for Microsoft System Centre Virtual Machine Manager, that tool will be designed to quickly help find machines suitable for virtualisation and should make managing datacentres easier, Ni says.
Microsoft expects to release Virtual Machine Manager to manufacturing in the second half of next year.


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M and I were discussing our obsessive need to eat at the same places or cook the same meals all the time. We found Lao Sze Chaun and were back within a week! As part of a challenge to make eating out, which is expensive, feel special and worth while, we are attempting to eat only at new-to-us restaurants for the foreseeable future. We'll see how it goes!
We hit a financial goal we had set for ourselves and this sushi dinner as a treat has been on the calendar for weeks! We headed over to Fin Sushi Bar which was just under a mile from home, so I made M walk with me! We got three rolls, a spicy tuna (not pictured), a Snow Burn and an Orange Salmon and finished with red bean mochi ice cream. Service was fast and knowledgeable. The atmosphere was clean but very cozy. If you are in Chicago, it's worth checking out!
Side note: I took these pictures in a super dark restaurant, sorry if they are blurry!


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Master Gardener: September garden chores for the organic garden
Southeast Texas had a nice spring and most of the summer was rather nice. But August has made up for niceness. This too shall pass. September is here and that means the fall gardening season has arrived — surely the rains will come on a more consistent basis.
To help landscapes get through the drought, add organic matter to flower beds and vegetable gardens. Compost will increase the moisture holding capacity of the soil. Add mulch to beds. A two to three-inch layer of shredded leaves, pine straw or native hardwood mulch will moderate soil temperatures and hold in moisture. The mulch also blocks light from reaching the soil, which is needed by most weed seeds to germinate. Several layers of newspaper underneath the mulch will enhance its effectiveness.
Several things can cause brown, dead-looking patches in the lawn: chinch bugs, grubs, take-all patch, large (aka brown) patch, drought or improper irrigation practices. Back for an encore performance, take-all patch is rampant in my neighborhood. I long ago threw in the towel and planted ornamental grasses and perennials to replace the lawn. Call the Montgomery County Extension office to receive a copy of take-all patch organic treatment. Bring in a sample of the lawn for diagnosis.Brown patch, now called large patch, caused by Rhizoctonia solani, is one of the most common fungal diseases, occurring most often in fall with the cooler nights. While large patch will not kill the grass, it certainly does weaken it. This fungus thrives under conditions of cool night temperatures, high nitrogen fertilizers, poor drainage and extended rainy periods or over-irrigating the lawn. Operate the irrigation system manually, only when rainfall is scarce. An inch a week is enough! Switch to a slow release organic fertilizer. Organic fertilizers not only help prevent over fertilization, but promote the growth of beneficial soil microorganisms that fight the fungus that causes large patch. Fertilize in mid-October. Using a fungicide is only a temporary fix. Decrease large patch with the use of organic practices and proper irrigation methods.
To diagnose your lawn's problem, take a sample of grass (from the margin between the brown and green area in the lawn) to the county extension office. Master Gardeners are there to identify the culprit and make recommendations.
In mid-September, fertilize all garden beds with 10 to 15 pounds of an organic fertilizer such as Microlife, Nitro-Phos Sweet Green, Soil Food or Texas Tea per 1000 square feet. Other organic fertilizers may be available. Cottonseed meal, while not technically a fertilizer, will add fertility and acidity to the soil. It is especially good for those acid-loving plants. Cottonseed meal varies in formulation slightly, but generally consists of 7% nitrogen, 3% P2O5, and 2% K2O. Always follow the directions on the label because the NPK ratio will determine how much to use. Continue foliar feeding annuals, perennials and vegetables with compost tea and a water-soluble organic fertilizer that contains micronutrients such as seaweed extract or fish emulsion. Seaweed extract has amazing properties. According to Dr. T.L. Senn's research at Clemson University, plants sprayed with seaweed repel white flies. They just will not lay their eggs on leaves sprayed with seaweed. Seaweed also helps plants cope with heat stress.
Snap beans planted in fall have the best flavor. They are sweeter than spring planted beans because they mature when temperatures are cool. Vegetables to plant include bush lima beans, bush snap beans, broccoli, cabbage, cauliflower, mustard and radish. In late September, plant beets, Swiss chard, Chinese cabbage, collards, kohlrabi and sugar snap peas. Wait until late October or early November to plant spinach seed. Spinach needs cool soil temperatures to germinate. Interplant herbs with the vegetables. Call the County Extension office at 936.539.7824 for a complete planting chart and seed source list.
Give repeat-blooming roses a light trim by cutting back one-third of the growth the first week in September to enjoy beautiful mid-October blooms. Dead-head spent blooms of other perennials and annuals to keep them flowering, but do not cut back any fall-blooming perennial such as asters, Mexican mint marigold, copper canyon daisy or Mexican bush sage. Early to mid-July is the time to cut back fall-blooming perennials.
In late September, plant flower seeds of alyssum, calendula, cornflower, larkspur, delphinium, hollyhock, lobelia, petunia, snapdragon, stock and wildflowers. Yes, those beautiful bluebonnets that bloom in April are planted in September. Some of these flowers are available as transplants. Save a few seed from purple coneflower for new plants, but leave the rest of the seed heads in the garden for the birds. Divide and transplant spring-blooming perennials such as daylily, Shasta daisy, violets, wood ferns, cannas and iris.
Invite beneficial insects to your garden by planting herbs, annuals and perennials that attract them. Cilantro, dill, parsley, yarrow, alyssum, Queen Anne's lace, asters and many other plants will draw beneficial insects to your garden next spring to fight the bad guys, insect pests.
Fall is a great time to start a compost pile. For tips on earth-kind garden practices, including how to compost, propagate plants and harvest rainwater, attend Woodlands Landscaping Solutions event on Saturday, September 28, 9:00 A.M. until noon. New location: The Recreation Center, 6464 Creekside Forest Drive in The Woodlands. Call 281-210-3900 for more information.
If you need to replace perennials, put the Oct. 5 Master Gardener Fall Plant Sale on your calendar.
Call Texas A&M AgriLife at 936-539-7824 with your gardening questions. Visit the Master Gardening website at http://www.mcmga.com/ for information on upcoming events and plant sales.


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Web Link / Source
Posted On: 21/May/2019
NEW DELHI: Drug firm Alembic Pharmaceuticals Tuesday said it has received approval from the US health regulator for Solifenacin Succinate tablets, used for treatment of overactive bladder. The approved products is therapeutically equivalent to the reference listed drug, Vesicare tablets of Astellas Pharma US, Inc.
The company has received approval from the US Food and Drug Administration (USFDA) for its abbreviated new drug application (ANDA) Solifenacin Succinate tablets in the strengths of 5 mg and 10 mg, Alembic Pharmaceuticals said in a BSE filing.
Quoting IQVIA sales data, the company said, Solifenacin Succinate tablets 5 mg and 10 mg had an estimated market size of USD 967 million for 12 months, ending December 2018.
The company said it now has a total of 94 ANDA approvals from the USFDA.


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For an event that should be fun, relaxing and free of stress, often times, all of the planning and logistics ends up turning a dream vacation into one big headache. Follow the travel tips in this article to reduce the stress involved in vacationing so that you can return from your next trip, relaxed and rejuvenated.
If you rent a car while traveling, request an extra key. In a new place, in a new car, your mind is bound to be occupied with other things. For people who already have a bad time of locking their keys in their vehicle, keeping a spare set on you at all times is a great idea.
Packing your suitcase smarter will enable you to bring more fun! The best way to maximize space in your luggage is to lay an item flat and roll it up. Roll as many things as you can and fit them closely together. Stuffing socks and underwear into your shoes will save you even more space.
When about to travel an important resource can be talking to friends and family about where you are traveling. Often one can gain helpful information that would have not otherwise be obtained. The advantage of talking to a real person can result in beneficial information that can make all the difference between an enjoyable trip or a miserable one.
If you enjoy alcohol, there's no better way when traveling, to get to know a new city than with a pub crawl. Visiting multiple establishments in the same night, will give an interesting cross-section of the city that you wouldn't gain any other way. Plus, you'll make some new friends.
Here is a tip for travelers! For tastier coffee when staying in a hotel, use ice instead of tap water. Many hotel rooms come equipped with a small coffee maker, but using tap water almost always results in poor coffee. Ice from hotel ice machines is made using filtered water. So, fill your coffee maker with ice at night (so it can melt), you can enjoy coffee made from crisp, filtered water in the morning!
You always want to make sure that you have a visa, if it is needed for entry into a county. Research exactly what you will need to present, to be allowed access to that location. Also, be aware that sometimes a visa will not even allow you entry.
Let your family access your travel itinerary. This will allow someone else to see where you are. You should also contact that person regularly. Hearing from you occasionally and knowing your whereabouts eases their minds.
Whenever you travel for business or pleasure, research your destination before you leave. Arriving in a foreign city without any idea where to go or what to see can be overwhelming and takes away from the experience. Read a guide on your destination and talk to people you know have been there. You can easily learn some insiders tips.
As you can see, there are a number of ways to reduce the stress of planning your vacation and simplifying the logistics. Make use of any or all of these tips when planning your next vacation. Instead of being stressed out, you will have the time and energy to truly enjoy your vacation.


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[LPC] Colonial Buildings
A collection of assets in the LPC style for building Georgian/Federal/neoclassical-style buildings of the American colonial period.
Preview also contains images from my upcoming medieval town decorations set, as well as from the LPC terrains and LPC bricks submissions. This set only contains the buildings!
Congratulations for winning the challenge @bluecarror16! Great job.:)
They look great, it's a well deserved win.
fantastic! Just looking at the previews, I can almost hear someone shouting 'The British are coming, the British are coming!' Great work! :)
Congratz on winning the challenge! :)
Hey these look GREAT. I was thinking of doing animations for the clock faces, unless you are willing to? Time is an important part of my game
Thanks! I don't have any immediate plans to do clock animations --- would love if you wanted to! I am trying to get around to releasing the roofs and non-building props features in the screenshots though... soon-ish...
Hey Blue, great work with the tiles! I got a question regarding the credits.txt however. Do I just need to put all of the names in the credits of my game, or do I need to put a link to the entire txt file someplace in my game? Thanks!


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I was born & raised in NH. Yes I guess that makes me a darn Yankee. Lately on facebook, I have seen a bunch of debates about the Confederate flag and what that symbol means to different people. Ok, seeing as I went to school up North, I did not grow up learning a whole lot about that flag. History was my least favorite subject in high school.
But then I realized that some people's flag was a little like NH's slogan on our license plates "Live Free or Die" actually the whole saying is LIVE FREE OR DIE, FOR DEATH IS NOT THE WORST OF ALL EVILS. It came from a Revolutionary war General, John Stark. It was always just a normal part of NH history, that I never thought much about it. Never realized that people in other states would think it was strange, until my family drove cross-country in 1998 to move to Kingman, AZ. Then all of a sudden people stared and laughed at the license plate. I still can't figure out why freedom was so strange to them. In NH, you have a plate on the front and the back of your car but about 7 months later when I got AZ plates, I only had to turn 1 plate over to the DMV so my oldest daughter hung the extra plate on her bedroom wall and she didn't mind explaining it to all her friends that would come visit. In recent years, the motto has come into debate because some religious people don't like the idea of doing anything that causes death even if that means they live as trapped slaves. So even though its rare and strange, you can find a car without the state motto on the license plate. Those plates say something positive like "Scenic NH"…because living free ain't positive.
1 of my sons has a big tattoo on the lower part of his arm and the words "Live Free or Die" is on display for everyone to see. Believe me, he has no problem debating freedom or history or religion.
Tomorrow is the 4th of July, or Independence day. I have to work 11 hours in a gift shop at Mt Rushmore. Some could think of it as a patriotic honor to be here now. First off, this country's freedom & independence had nothing to do with July 4th, well except that the writer of the Declaration of Independence died of the 4th of July. Actually Presidents John Adams & Thomas Jefferson both died on July 4th, 1826. But if they were sooo great for writing a "declaration for independence" for equality, then why did it take so damn long for blacks, native americans, or women to get any rights? They were living in this country at the time it was written. Obviously having everyone being totally equal was not what they had in mind.
It's strange but the first day I walked out to see the faces on the mountain here, Jefferson's eyes seem to be looking upwards. Like someone thinking or looking up towards the future. Not sure if that's how the carvers wanted him to look but that was my impression. Also makes me wonder what Jefferson would think of how the future ended up being in this country. I will say that Jefferson will never be my favorite president but he does have the best eyes on the mountain.


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Lose up to 15 pounds with 1 little trick
When I was younger, I probably couldn't have put on weight if I tried.
I was a competitive track athlete and rower, and played basketball in college.
But the older I get, the more I have to work to keep the pounds off. And the same is true for lots of my patients.
I've seen so many of them struggle with weight issues, and I know how heartbreaking it can be.
You work so hard… and the scale just doesn't budge.
But new research shows it's NOT your fault.
And now that you're off the hook, I've got something else for you: I've got a way to bring your waistline back under control in as little as 30 days.
Dramatic and effortless weight loss… in just 30 days
Two new studies show you're being undermined by your own body.
The first, from Dartmouth University, shows how the brain's reward system can short-circuit easily in many people – maybe most people. It makes true control over cravings and appetite almost impossible, especially when you're feeling stressed out.
But let's say you overcome that, get control over your cravings and lose weight.
Well, that's where the second study kicks in…
It reveals a built-in process that undoes all your hard work – a mechanism in your body that clings hard to every calorie to prevent starvation.
It almost FORCES you to make up for the lost weight by eating more.
Next thing you know, the diet that seemed so successful… at first… has backfired and you're regaining all your lost weight.
Well, I've got a way around it.
It's based on the paleo diet that's all the rage in some circles. The one big knock against it is that it's REALLY hard to follow for the long-term.
But here's the thing: I don't want you to follow it for the long-term.
You're certainly welcome to try, of course. It's a great lifestyle overall. But I've found that you can see dramatic weight loss and other incredible benefits by trying a modified version of it for just 30 days.
There are a lot of ways to go paleo but the simplest is this: Give up ALL grains for a month.
That one step alone often leads to better digestion, more energy, clearer thinking and – here's the big one – rapid weight loss.
You can expect to lose 10-15 pounds in that SINGLE MONTH.
Get plenty of healthy animal proteins, whatever vegetables you like and carbs from legumes and such (but of course avoid anything with added sugars).
Yes, this might be tough to follow "forever."
But 30 days?
You can handle that – and when you see how rapidly the weight comes off, there's a good chance you'll become more mindful of how grains affect you and will eat less of them even after the 30 days are up.
You might even decide you don't need any grains at all.


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Topic : Topics for an environmental research paper.
Author : Russell E. Smith.
Published : Sun, Jun 7 2020 :8 PM.
Format : jpg/jpeg.
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It always amazes me the questions and looks pregnant women get right before they give birth.
There is the, "Oh my, you must be due any day now. How long do you have?" 2 weeks. "You must be so ready to have this baby then". Frankly, no. I'm aware of what's coming...a newborn.
Then there is the phone calls. This happens mostly with my mother. If I call twice in a row without her answering, I guarantee the first call back will start with this, "Are you in labor?" No mom, just asking about a recipe.
This is my favorite. "You must be having a boy." This drives me crazy for some reason. Probably b/c I didn't know with my first two and I just don't want to give people the satisfaction of being right. Purely my own issue.
Then the looks. I never knew one person could gain so much pity just by putting on an extra 30+ (we won't give the real number here) around their mid-section. It's almost as if they think I don't know it's there. "Are you aware of that ball underneath your shirt?" Yes, I'm aware and I know how it's going to have to come out too.
A picture will follow soon. Almost 38 weeks!
Sunday, July 12, 2009
the end of pregnancy
It always amazes me the questions and looks pregnant women get right before they give birth.
Posted by kate at 5:00 PM
4 comments:
- Julie said...
I remember stopping with my husband for coffee the morning we were going to be induced. I SO badly wanted someone to ask how much longer so I could say TODAY TODAY TODAY! Mom calling back wondering if you're in labor cracked me up - I felt like everyone was so worried and thought I was so fragile.
- July 13, 2009 at 8:36 AM
- rebecca said...
HaHa!! I love the "I'm aware of what's coming..." line! The last 15 minutes of labor and the first year are huge hurdles to overcome for me when deciding to have another child. Ouch and a year of no sleep.
You funny Kate.
- July 14, 2009 at 1:47 AM
- Dena said...
it was great that everyone always returned my calls.
i made a button that said DUE MAY 28, all in pink letters...I got tired of being asked. Funny how with the first you HOPE people ask you...
the end prize is SO worth it!!
- July 14, 2009 at 1:26 PM
- Katie said...
Oh man you crack me up!
- July 19, 2009 at 7:15 AM


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Home › Forums › User Role Editor Pro › If logged in redirect to Login Redirect url? › Reply To: If logged in redirect to Login Redirect url?
August 20, 2015 at 11:53 pm #14887
Sorry, i had totally missed your answer =)
Tried it this morning and it works great as it seams. It gives error if the user's role has no redirect role.
Like admin account but that is something that is acceptable.
Your the hero of the year!! Wow, thanks for the exceptionally grate support.


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Tips You Need To Know About Booking Airline Discount Tickets Through Online
A lot of people loves to travel from different places especially if you are looking for an adventure. Specially when you are going to travel to a far places, you need to buy ticket for a plane. It is where you can have transactions to airlines through online and book your tickets anywhere you wanted to go. The benefit of booking through online is that it is very easy to book. There are a lot of websites that offers this services and you can search for them through the internet. This advantages is that there are tickets from multiple airlines and they can choose where they can ride to. The customer only need to fill some information and outline of their travel plans. But for these things to happen you need to have some guidelines through online booking.
By this you can get the biggest discount of your ticket. It will help you a lot to save time and effort. There are a lot of discounted tickets that you can find from different airlines. It is said that the earlier you book the more options you can have too.
The next tip is that keep updated about the announcement of the airlines. There are only fare tables that are valid for set of a certain period of time. This will be a great advantage for you so keep updated for the promos.
Don't just refer to a single online site and search for another one. By this you can now get the biggest chance of having a bigger discount fare for your ticket. There are a lot of web sites that can ease and minimize the problems of hassles.
You might consider on hiring for a low cost carriers in which they can help you carrying your heavy things. But the problem is that they are not listed on the travel sites.
Traveling through airplanes can be easy and less hassle to begin with. You just have to be a wise traveler. More importantly this will be your steps to have a great vacation and travel.
What I Can Teach You About Tickets


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Dear OzShut
My family and I would like to say thanks for the new Roller Shutters. We've wanted Roller Shutters for a while now and finally, we have them. Big thanks also to Adam for his friendly assistance and getting us a great deal, also to the tradie for the swift, professional installation.
Burzan Family


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Our team bring a varied and comprehensive range of skills and experience across a broad spectrum of major construction projects.
Beginning his career in construction within his family's business, Stephen has remained at the heart of this business and now operates as CEO. His commitment to an honest and thoughtful approach is reflected in all aspects of the business today
With over 30 years' experience, Stephen was appointed Managing Director of Linear Projects with a clear vision to develop the business into a full supply and fit out company working directly with leading main contractors across the UK.
Appointed CEO of Linear UK Group in 2018, Stephen oversees both Linear Projects and Linear Design & Construct with a clear focus on both short and long-term planning and decision making. Working with the senior management team, Stephen helps drive the evolution of the business, its people and its projects to the very highest standards he sets for the Group.
Throughout his career, Gareth has played a very hands-on role in the delivery of projects and contracts. Working from the Glasgow office, on a day to day basis he oversees all aspects of live contracts, liaising with staff and clients at each and every stage of the construction, from tender to completion.
His unwavering commitment to the people and the best outcomes demonstrates his highly considerate and collaborative style. This is regularly seen in his drive for the optimum approach to HSE matters and also the wellbeing of the team.
Having worked at Linear Group for 25 years, Gareth has played an integral part in the growth and development of the business and he prides himself on the strength of his commitment and a consistently honest approach.
Scott worked for some of the UK's leading principal contractors, focusing very much on the commercial aspects of project development and delivery.
In 2017, Scott was appointed Commercial Director of Linear Group to oversee the commercial strategy for the group. In this role, his focus is varied and touches on all aspects of the operation. From managing risk, compliance and budgeting, to optimising bid offers and leading negotiations, Scott calls on his commitment to collaboration and honesty to ensure the right values and behaviours are embedded into the organisation.
Scott works closely with all the Project Managers to ensure he has visibility and insight into the numerous projects ongoing at any one time. This enables him to adopt a value adding and diligent perspective, focused on quality and efficient client delivery.
Beginning his career in 1997, John has acquired valuable experience of the industry from both practical and commercial perspective.
Joining Linear Projects in 2010 as Senior Commercial Manager, John became responsible for ensuring commercial processes are adhered to as well as the improvement of processes and procedures across the business.
In his role, John takes a client-focused approach in all areas of his work he is actively involved in the management and delivery of major projects both commercially and operationally. This sees him supervising and mentoring the site teams to ensure their development and accountability is optimised.
Kate joined the team at Linear Projects in 2011, progressing from estimating onto bid and project management. She has hands-on experience of the foundations of the business and its specialist trades offering.
In her current role of Estimating Director, Kate's focus is on leading high value, complex bids that encompass multiple packages and which require extensive pre-construction work. This sees her working across a variety of specialist areas and a diverse range of clients.
A key highlight for Kate was the end-to-end delivery, from tender to practical completion, of the FIS Gold Award-winning new Macallan Distillery and Visitor Experience fit out with Robertson and leading architects, RSHP.
During his career in construction, spanning over 20 years, Andrew has managed the delivery of many developments to the highest standard of quality. These projects helped develop his skills in the management both site delivery teams and also the full range of stakeholders from clients through to design teams. Most recently he has applied his extensive experience to the management of multiple projects and teams on numerous, varied projects.
Andrew was appointed Project Director for Linear Projects in early 2018. In this role, he is responsible for managing client relationships through regular liaison and communication; monitoring and reviewing progress; quality control; risk management; team leadership; sustainability; stakeholder engagement and overall planning. Andrew is committed to a consistently honest approach with a clear focus on reliability and diligence.
In 2007, following 25 years working in accountancy firms, Veronica joined Linear Projects to oversee the financial management function, bringing with her a diligent and dedicated approach.
For the past eleven years, Veronica has been overseeing this function including budget management, assisting in the implementation of legislative change and the delivery of company and management accounts. During this time with turnover rising from £4m to £19m, she has overseen the introduction of the Sage Construct Management System and Sage Accounts.
She now manages the finance department which supports both Linear Projects and Linear Design & Construct.
With over 20 years' experience of health and safety, Garry Willis brings exceptional expertise and hands-on knowledge to Linear Group.
A proven innovator and leader in his field, Garry has an impressive range of qualifications including NEBOSH Diploma, OHSAS 18001:2007 Lead Auditor, Mental Health Instructor, IOSH Fire Risk Assessor and NLP Practitioner. He has successfully developed training and coaching programmes, alongside the effective implementation of safety management systems.
At Linear Group, his role is to nurture, develop and promote compliance, achieve excellence through a strong health and safety culture and coach colleagues to ensure the right solution every time. As part of this, Garry will oversee the development and implementation of the full safety management systems to ISO 450001:2018, as well as utilise his main contracting experience and insight to assist the ongoing development of Linear Design & Construct
Since beginning her career in construction in 2006, Julie has acquired strong skills and experience having worked for two large corporations, Laing O'Rourke and Iberdrola. Alongside this, she achieved her MSc in Construction Management then went on to become chartered with the RICS in 2011 and has since become an APC Assessor.
Julie joined Linear Projects as a Senior Quantity Surveyor in 2017 with responsibility for the commercial and contractual control on projects.
A reliable and collaborative member of the team, Julie takes a hands on approach to ensure risks and opportunities are identified; subcontractor orders and payments are managed; valuations are shared with the client in a timely and accurate manner and trainees are well developed and managed.
With responsibility for all Quality and Environmental Management Systems across the Group, Claire delivers vital expertise and skills to the business whilst adapting to change and supporting the varying needs to the team.
Claire joined Linear Projects in 2013 and successfully achieved the transition of ISO 9001 and 14001 to 2015 standards, as well as also incorporating the Manchester office and now focusing on integrating Linear Design & Construct.
On a day to day basis she is tasked with ensuring the systems are managed, developed and maintained to enable to each business to operate to the highest standards. As a key part of this Claire drives a culture of continuous improvement to foster the highest levels of customer satisfaction.
In 2002, Tommy joined Linear Projects and has been integral in driving successful fit out contracts specifically across major PFI and Design Build Construction projects. The focus of his expertise is very much in the areas of strategic client development, multi-disciplinary team management and project delivery. Through his composed and creative approach, Tommy effectively builds and facilitates cohesive teams and forges positive interfacing with public agencies and key stakeholders.
A commitment to accountability sees Tommy play a vital role in managing all strategic aspects of large projects, particularly focusing on mitigating risk. He successfully combines a range of skills and knowledge to ensure first-class client management alongside a drive for continual improvement and positive change.
Beginning his career as a cabinet maker, Dale progressed through the ranks of the construction industry, acquiring skills and expertise in a variety of roles. He moved from the sub-contracting arena to main contracting with Laing O'Rourke in 1996 and then went onto work for Styles & Wood, combining his trade experience with project management.
Dale joined Linear Projects to establish the business in Manchester in 2008. Since then he has overseen the growth and development of the office and driven its successes. On a day to day basis, he leads the team of 12 ensuring a consistently transparent and proactive approach in every aspect of the business and its delivery. His commitment is rooted in a highly motivated, decisive and positive outlook which has enabled a clear focus on fulfilling the business ambitions in the North West of England and beyond.
Following a BSc (Hons) in Quantity Surveying, Jeff worked across a range of related businesses acquiring strong skills and experience. Latterly he ran his own business, further strengthening his expertise and proactivity.
Joining Linear Projects in 2018 as Commercial Manager, Jeff took on responsibility for the commercial and quantity surveying aspects of projects run out of the Manchester office.
In his role, Jeff takes a methodical approach to his work to ensure the most robust and appropriate outcomes for both clients, projects and the business as a whole.
Our team demonstrate a strong commitment to collaboration and transparency. They each bring their own expertise, experience and skills to create a strong and unified workforce.


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Sorry, no definitions found. You may find more data at benjamin peirce.
Sorry, no etymologies found.
˜Benjamin Peirce: mathematician and philosopher™, Journal of the history of ideas, 16:
Benjamin Peirce did not think of himself as a philosopher in any academic sense, yet his work manifests interests of this kind, in two different ways.
Further examples of in - ternational cooperation in the peaceful investigation of our cosmos were provided by corrections of Lever - rier's computations by John Couch Adams in England and Benjamin Peirce at Harvard.
Professor Benjamin Peirce, which the average student
History of the University of North Carolina. Volume I: From its Beginning to the Death of President Swain, 1789-1868
The degree of Doctor of Laws was conferred on Benjamin Peirce, of
History of the University of North Carolina. Volume I: From its Beginning to the Death of President Swain, 1789-1868
Notable among the mathematicians were Nathaniel Bowditch, Benjamin Peirce, and Thomas Hill, who was president of Antioch College and of Harvard
The following letter to Professor Benjamin Peirce, who was then Superintendent of the Coast Survey, shows, however, his unfailing interest in the bearing of scientific researches on questions of public utility.
So entirely did he seem to have recovered, that in the course of the winter the following proposition was made to him by his friend, Professor Benjamin Peirce, then Superintendent of the Coast Survey.
Professor Benjamin Peirce; but I did not know that he had interested himself in political economy until, on the occasion in question, I passed an evening with him at the house where he was a guest.
So, instead of founding the office in Washington, it was established at Cambridge, the seat of Harvard University, where it could have the benefit of the technical knowledge of experts, and especially of Professor Benjamin Peirce, who was recognized as the leading mathematician of America.


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This video is produced by the American Association for the Advancement of Science and features AAAS CEO Alan Leshner and teachers from Dover, Pennsylvania, discussing the importance of teaching evolution. It does a great job in distinguishing the difference between intelligent design (ID) and the scientific process. As it was pointed out, science is based on a series of investigations, tests, comparisons, giving facts, and concrete evidence to substantiate the findings and prove or disprove the hypothesis. ID is based on religion and theory with nothing, other than belief, to prove the theory. Jennifer Miller made a good point when she said that she is not qualified to teach religion and that it is more appropriate for philosophy or religion classes.
Going Further
You can use this video to learn more about some of the issues surrounding the differences between evolution and intelligent design (ID). This video also provides you with a look at how the teachers in Dover, Pennsylvania dealt with an effort to try to force them to teach ID along with evolution in their science classes.
This video is likely more of a tool that you can visit to learn more about the issues. If you choose to use it in class, however, the video is best suited for high school as those students are more capable of making an informed decision. If it were presented to middle-school students, they should be in an advanced science class or the "Gifted" program.
The Illusion of Race
6-8 | Interactive
Comparing Species through the Fossil Record
9-12 |
Introduction to Natural Selection
9-12 | Hands-On
Smallest Thing
6-12 | Audio
The Macaque Genome: An Interactive Poster
9-12 | Interactive