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Difference between revisions of "Talk:2009 Group 4 Project"
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Revision as of 20:48, 2 June 2009
--Mark Hill 14:39, 3 May 2009 (EST) OK Guys, looks like you are back on track (get it?) so I will look back here in a while and see how you are getting on.
--Mark Hill 13:33, 19 March 2009 (EST)I fixed your topic layout and have moved microscopy assessment off your group project page to here.
A (was reviewed as a group)
- Content - incredibly dense and probably over the word limit. However, nevertheless in reading through i suppose there isn't really much that you guys could cut out as its all quite well thought out and laid out.
The structure looks good. You're structure looks good. Your content has a logical flow. It is easy to read and well spaced out. The timeline just needs to be completed or deleted from the page. The images on this page are well placed in relation to their respective text and they are all sourced except for the first. Is this the student drawn figure? Make sure you correct this.
- Good use of diagrams, the animations of the different pathways are quite impressive and a useful aid.
- The glossary is quite thorough, clear explanation of words. Will be better if you can improve the format so it's easier to refer to; such as making the main words bold, and using dashes " - " consistently.
- The youtube video link under "Ras-MAPK (mitogen-activated protein kinase) Pathway" is very helpful, the links to the individual member's pages were also placed appropiately.
B: Group 7
- Intro: Perhaps a little too in depth for an introduction - try to use 'easier to read' language.
- Structure + Function: A picture would help to illustrate what you're saying. Well set out.
- Dynamic process: "Phosphorylation of an additional seven tyrosines within this region promotes signalling by providing docking sides for adaptor proteins which regulate signalling-cascade couples." Include in the picture an explanation.
- Animations are great!
- PKC pathway: good but try to break the text up a bit with either dot points or numbers.
- Current research: Try to find research from the last couple of years. Dr. Hill might not think 2000 is 'recent' enough. For the second entry, which publication is referred to in "In a recent publication"? We, however, understand that you'll fill out that reference bracket after it.
- Overall: Great setting out and headings. The information is quite biochemical which you could probably condense into simpler, easier to read text. Picture legends and referencing need revision (they're a little short).
- All links present. Still missing references!
Location of Electron microscope facilities at UNSW:
Basement, Chemical Sciences Building (F10), Kensington UNSW Sydney NSW 2052
Link to electron microscopy Unit,UNSW
--Hamid/Arash Araghi 11:45, 09 March 2009 (EST)
Thanks Mark...
So, I'll open the discussion with an invitation to group members to pick an area to specialise... the suggestion has be made that we each do receptor sub-classes and specificity... ideas?? thoughts?? suggestions??
also, has anyone had any luck tracking dow the mystery team member: (3189925? is it?)
That is all. --Peter Kehoe 10:22, 23 April 2009 (EST)
hey guys, yes, I eventually found the mystery number of our team member. Its a 'familiar face' who will be joining us from week 3; (I can't name him here on wiki). It seems that he has not loged into his wikim page yet.. Not sure if he has access yet/ he totally forgotten about it.. anyhow, it will be sorted out hopefully by thurs and so we can devide the group project between the members of the group... I'm still doing some readings on 'Trk receptors' to get an overal view of what we/ and I would want to take inpart for further info search...
--Hamid/Arash Araghi 17:25, 27 March 2009 (EST)
"self" individual assignments:
- 3187854 - P75NTK protein/receptor
- 3189925 - Trk A
- 3191358 - TrK B
- 3189168 - Trk C
A good guidline for these might be:
- what is it?
- How is it different from other proteins/receptors?
- Why is this so?
- what tissues might you find it in?
- what is the adaptive advantage of this?
that is all --Peter Kehoe 12:33, 26 March 2009 (EST)
Guys, just to clarify; The above topics are NOT part of the collaborative group assignment. the collaborative assignment covers the overall process of production, molecular interactions and signal transduction of Trk R.'s as well as the current field of research and diagnostic techniques etc etc etc.
The individual assignments cover the specificinteractions and roles unique to the above proteins. Realistically there should be little to no overlap between the two despite the fact that they are, of course, inherently similar- The trick to the group assignments is to BE SPECIFIC, whereas the group work is a wholist generallised view of Trk R.'s
--Peter Kehoe 12:20, 2 April 2009 (EST)
some general information about signalling processes requiring Tyrosine Kinase receptors;(from molecular biology of the Cell/garland science text book)
"Table 15-4. Some Signaling Proteins That Act Via Receptor Tyrosine Kinases
Epidermal growth factor (EGF) EGF receptor stimulates proliferation of various cell types Insulin insulin receptor stimulates carbohydrate utilization and protein synthesis Insulin-like growth factors (IGF-1 and IGF-2) IGF receptor-1 stimulate cell growth and survival Nerve growth factor (NGF) Trk A stimulates survival and growth of some neurons Platelet-derived growth factors (PDGF AA, BB, AB) PDGF receptors (α and β) stimulate survival, growth, and proliferation of various cell types Macrophage-colony-stimulating (M-CSF) M-CSF receptor factor stimulates monocyte/macrophage proliferation and differentiation Fibroblast growth factors (FGF-1 to FGF-24) FGF receptors (FGF-R1-FGF- R4, plus multiple isoforms of each) stimulate proliferation of various cell types; inhibit differentiation of some precursor cells; inductive signals in development Vascular endothelial growth factor (VEGF) VEGF receptor stimulates angiogenesis Ephrins (A and B types) Eph receptors (A and B types) stimulate angiogenesis; guide cell and axon migration
more from this book at:
cheers, --Peter Kehoe 09:58, 9 April 2009 (EST)
additionally heres a cool link to Trk-B complexed with neurotrophin structure *Trk B... isnt that someones assignment? hint hint*
Hey Guys,
If you have difficulty understanding Trk concept, take a look at this animation; I will later on include this animation in our group project...
--Hamid/Arash Araghi 17:48, 15 April 2009 (EST)
Guys we're really lagging behind in posting things... i'll start posting on the main page tonight (hopefully) please do likewise. --Peter Kehoe 10:27, 23 April 2009 (EST)
arghhhhhhhhhhhhhhhhh Just before I hit the save page button, I wanted to see how this message would look like. My internet got disconnected and now I have to type it all again.
Very thanks to Peter for taking the initial step to post on the main page. Of course, there are parts in his post which need to be improved. I will start posting some material tonight and/or at the weekend. Most likely, I will make some minor changes to the other member's post. As Mark mentioned in the lecture today, he wants us to actively take a role in posting things on the main page and discussing over our project on this board. Please guys feel free to do some changes to my post in order to make yours to fit in. Also I will appreciate if you could comment on my postings.
As per our conservation in week 3 of the session, one of us will do the proof reading and make changes to our posts so that each of our own style of writing will connect from one point to another. Otherwise, our work may not flow, and look a bit clumsy. --Serkan Erkan 15:28, 29 April 2009 (EST)
Morning Guys, I need to address few important issues here.
Firstly, please make sure you do a thorough research on the topic before writing on the page. Believe me writing on the page is the easiest part. But finding and digesting the info, particularly in this topic is a little tough. The reason I said that is because 'Tyrosin Receptor Kinases' are not restricted only in Neural cells, also involved in normal cells. so perhaps you'd need to read more on that…?!!!
Secondly, in order to make the most out of this group project, I personally believe that we should divide the topic evenly between four members of the group. This way we'd ensure that 1) everybody has had a fair go. 2) Prevents further confusion. 3) Prevents waste of time and overlapping info. Hopefully during our peer-review session we can then follow members' works easily without any confusion.
For Now, I'm advising everyone that I will be doing the Introduction that will include evolutionary info on Trk as well as its identification in human genome project. I will also create a distinct subheading talking about the cause of some cancers. eg: colon cancers and its relation to Trk receptors. Please avoid touching my assigned topic :-D thanks. :D
So there will still be function, structure, dynamic processes and current research left which needs to be assigned… so people hurry up and assign yourself…and let us know..
We also need to have a group deadline by which everyone will be done with their topic and so we can run a peer-review session, which we will basically review and make improvements on our project… I'd prefer by the end of Week 8 (next week).
Lastly, as a reminder we are doing our topic on Trk receptors Not Tm (Tropomycin) receptors… I changed it back to Trk.. just to avoid confusion.
--Hamid/Arash Araghi 08:27, 30 April 2009 (EST)
It seems like my last post has been deleted. As per our discussion in today's lab, I will do the "Function" section and add onto the "Structure" section on the weekend. Meanwhile, check this board daily to be up-to-date with the project.--Serkan Erkan 15:21, 30 April 2009 (EST)
Serkan, I remember you collected few good journals on 'K-Ras oncogene'. could you please forward them to my email as they are more related to my section?? thanks.
--Hamid/Arash Araghi 02:04, 2 May 2009 (EST)
Arash, not a problem. I have forwarded the items to your unimail. I hope they will be useful for yor section.--Serkan Erkan 12:00, 2 May 2009 (EST)
Each of the seven subfamilies of the Trk receptors are distinct in their own ways. We can describe their structures. Please see the link http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mboc4.figgrp.2848
I also did some posting on Function and a minor contribution to Structure, and added two references. I will do further posting for the Function and Structure by the end of the weekend --Serkan Erkan 17:26, 2 May 2009 (EST)
Hey guys, I've been watching the posts go up over the weekend but have been unable to contributed signifcantly due to demands of other projects/exams- I will do so tomorrow night and continue my signal-transduction diagram. You guys are doing fantastic work... things seem to be working smoothly now :)
K-ras oncogene require disambiguation i think... could you clarify for me... K-ras is definately a known oncogene and a common element in many signal transductive pathways... the K-ras proteins is structurally and functionally distinct from TrK, however they do participate in some cascade pathways... I was of the understanding from other studies that the TrK oncogene and K-ras oncogenes are not interrelated(loci?)... it is also notable that although K-ras and Trk DISfuction can contribute to cancerous cell formation they are not the only factors, the presence of significant mutation at these loci does not define a cancerous cell but it does contribute to oncogenesis I'm interested to see how you are tieing these two oncogenes together.
Cheers, --Peter Kehoe 23:49, 3 May 2009 (EST)
important notice: after many episode of discussion and confusion, it has finally been decided that we are definitely doing the TrK pathway - the tyrosine kinase pathway specifically known as tropomyosin-related kinase. Confusion arose from disambiguation between conversations in class relating to TKR's and Trk's. So, we are DEFINITELY doing a Trk pathway. Sorry for the confusion.
Thanks to all members and Mark for working on this to alleviate the confusion!!!
A lot of the beginnings of these processes are already done on the wiki site but cleanup needs to be done to make sure all processes related to Trk's and not TKRs. The dynamic processes, etc are the same however the ligand specificity and dimerisation structure is more specific for Trks.
the workload is as follows (as we have a lot of catching up to do since the confusion has put us WAY behind other groups)
Intro+current research(oncogene)+ K-ras (not sure where this fits yet)+ assorted- Arash
Structure+ function(A,B,C specific)+ (PL3 summary and individual) - Serkan
Timeline+ Glossary of terms+ PKC (summary and individual) - Dan
Dynamic Process + Structure + disambiguation explaination+ P75NTR - Peter
--Daniel Manassa 12:59, 7 May 2009 (EST)
Morning guys,
Intro has now been added... Lots of ideas are flowing on my mind!!!
I am removing K-ras as it would be irrelevant to our current topic... (Peter and I discussed this yesterday). Instead I'll be talking about oncogene...
Also, I was thinking of giving a background info about Neurotrophines. Though I'm not sure if anybody is covering this explicitly ??!!! if Not, then It'd be a good idea to throw it in. think about it and we'll discuss it in the lab.
see ya soon. Arash --Hamid Araghi 08:54, 14 May 2009 (EST)
i'm happy to do a neurotrophin summary as i've already covered most of that to do my individual work. let me know if you'd like me to do this. No doubt i'll discuss in lab today, will be arriving an hour late. --Peter Kehoe 10:50, 14 May 2009 (EST)
hey guys,
my part is almost ready. I am busy with another assignment right now, which is due on monday. I will post my part on the weekend.--Serkan Erkan 11:53, 14 May 2009 (EST)
just talking to Serkan realised that we don't have an image of the receptor pathways. I will work on it this weekend and make one. if anyone else is doing it let me know before Friday. I will start the glossary tonight, but will finish once all text is uploaded. The Time line is pretty complex, but it is an image. I wont upload until finished.
excellent... yes as long as you cover that in your section, it'd suffice...
--Hamid Araghi 12:17, 14 May 2009 (EST)
the 2nd above post is not me.. it think its Daniel? in anycase, i'm already working on an image... only just got the message
--Peter Kehoe 20:46, 15 May 2009 (EST)
Hi everyone,
The two topics "Mechanism of Trk Activation via multiple Signalling pathways" and "current research" have now been partially added. There are parts, which have been tagged, would need to be completed by members...
So, please for time being keep things that have been added so-far unchanged. once everybodys done with their parts, we'll then run a thorough editing/proofreading
One of my youtube animation doesnt work.. dunno why.. i'd need to fix that prob..
Nevertheless, we are getting there... :D
cheers Arash
--Hamid Araghi 11:23, 20 May 2009 (EST)
okay guys, we're slowly getting there... the diagram is coming together though ive still got alot to addd to it and need to post up dynamics... iguess the point is here that we dont have much time for post-completion editing so everyone post as finals over the weekend and if nescessary the typos etc can be edited out by us as we read through eachothers....
Take care all
final edits
okay guys, as per our discussion in lab this week we need to make the final edits on our page... please post as you complete ASAP and comment on eachothers edits
Goodluck guys--Peter Kehoe 15:34, 30 May 2009 (EST)
Put a new intro on, let me know - yes or no? --Peter Kehoe 16:31, 30 May 2009 (EST)
Peter,New intro will do. Also, i thought of the hand-drawn image if it should be moved somewhere else? like function/structure???
Guys,I changed the orientation of some image.. see if you like it that way.
Another issue, make sure u label ur images with well description of what they represent.. and if necessary refrence them.
btw, I thought we'd need to write a reflection on our work?!!! can somebody clarify this?
--Hamid Araghi 18:15, 30 May 2009 (EST)
Not sure about the reflection... :S thoughts anyone??? please contribute to the discussion so we know what ypu're doing... Also, as per our discussion in lab, the sections that overlap with your individual projects are too lengthy! Please shorten them and contribute further to other sections... you should be doing stuff! if you're not sure what you need to be doing then ask someone on here!!
Please guys, we need this finalised.
Hamid, I'm aware i've been naughty wiht my images, i'll clean up the tags.
Cheers and all that!
--Peter Kehoe 11:18, 1 June 2009 (EST)
hey guys,
I agree with peter about the overlap with individual projects. I will shorten the section, PI3K pathways. Instead of stating its function and mechanism, I will talk about the relevance of the pathway in Trks.
I will try to fix the "Function" and talk about the ways in which receptors interact with the ligands.
Is there anything else? Hmm Peter, do you think structure should be left the way it is or we should talk more about it? it looks concise the way it is. Any thoughts? I will check the discussion every few hours until wednesday.
--Serkan Erkan 14:32, 1 June 2009 (EST)
I've done a bit on structure today, i might change the formatting a bit and add a picture. I was going to mess around a bit with function and talk about knockout mice in a sub section, but because it's partitioned it should be okay... also i'm continuing work on dynamic processes so dont sweat that part... anyhting else?--Peter Kehoe 17:08, 1 June 2009 (EST)
final edits
daniel, still waiting on the timeline stuff... i'm adding knockout mouse stuff tomorrow as i left my article for it at home...
can someone talk me through the referencing component as i'm still not solid on it and my paragraphs are not referenced
--Peter Kehoe 19:59, 1 June 2009 (EST)
Send all your referenced paragraphs to Dan. He is responsible for the arrangement of reference section. here is the email of his: [I deleted his email address as it is not appropriate to post it here without his permission. PETER, I will email it to your unimail.--Serkan Erkan 21:16, 1 June 2009 (EST)]
--Hamid Araghi 20:54, 1 June 2009 (EST)
This is how you reference it. Click edit to view it. [1]
if you do referencing this way, then you dont need to order it. it ll happen automatically.
i had a read of structure. very well done. i ll do the function late tonight. you can all peruse it tomorrow. --Serkan Erkan 21:16, 1 June 2009 (EST)
Peter, I see you have talked about selectivity and specificity of receptors and that it's because of distinct variations in the receptors. [This is good] But it is worth mentioning where all these variations in extra/intracellular receptor domain arise from??!! Just that you can be more specific but really depends on how well in depth you'd want to dig into. I have found a paper that describes 'splice variants of Trk receptors" mainly originated from genetic allele, and that it is the main cause of variation between Trk receptors and moreover influential by being selective/specific toward their target substrate. For instance, TrkB lacks exon9 in the extracellular domain,which decreases its interaction with NT4/5 and NT3. Also, apparently, splice variants of TrkC have been found lacking the tyrosine kinase domain. This can be linked well to both figures 1 and 2 I guess!.
Here is the paper I have attached in:
Bibel,M, Barde,Y,A. "Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system".Genes Dev. (2000).14(23):2919-37. PMID: 11114882
another issue in introduction is that we say "Trk's are commonly found throughout mammalian tissue types and bear particular signifcance in embryological development and maintainence and growth of neuronal cell types." Although, trks are found commonly throughout variety of mammalian tissue types,they are in very low abundance in vivo. Conversely, we can find them in high abundance in neuronal cells. perhaps we'd need to fix this too?? hope I haven't made you guys confused ;)
--Hamid Araghi 10:47, 2 June 2009 (EST)
Hamid, I dont have time to read, comprehend, integrate and potentially edit on relationn to those issues, please feel free to add within my sections wherever you feel it might help. At this point i feel my tampering in articles i dont yet understand may do more harm than good. Thoughts>? --Peter Kehoe 17:17, 2 June 2009 (EST)
is there any reason for deleting PLC-Y1 pathway?
--Hamid Araghi 19:27, 2 June 2009 (EST)
if i deleted it, it was an accident because i havent touched anything other than my own intentionally :S--Peter Kehoe 19:30, 2 June 2009 (EST)
okay so all my text is in, im just adding some referencing now and we should be golden.... Does anyone know whats happened ot Dan and the timeline?? the individual-overlap sections still need to be cut down by thier respective authors.... *pulls out hair*--Peter Kehoe 19:29, 2 June 2009 (EST)
hmm im not sure if Dan has deleted that section or...
i dont get why my references are doubling up :S any help??
F**K what happened!! :S references exploded... all i did was add a couple in my text --- okay fixed lol
I think we are gonna have a big crisis if you keep referencing. you can undo what you have done by going to "history" and undo.
please stop referencing until I get Dan or Serkan to fix it
Should be fine now yeah?? i think i've figured it out lol--Peter Kehoe 20:26, 2 June 2009 (EST)
it actually made me laugh.. :D glad u got it sorted.. but im still worried about disappearance of PLC-Y1 pathway... --Hamid Araghi 20:32, 2 June 2009 (EST)
me too can you add it back in... i think i've done everyhting now, are you happy wiht my contributions? anyhting i've missed?


text:
The full text of Gov. Andrew Cuomo's 2013 State of the State runs to more than 300 pages, spanning almost every conceivable topic, from economic development and clean energy to gun violence and government reform. It is both a progress report and a sweeping agenda for more change.
Without question, Mr. Cuomo's report is a tour de force, and within its pages are numerous proposals that will be embraced by the business community. These include reform of workers' compensation and unemployment insurance regulations, with the aim of cutting businesses' costs by $1.3 billion; the Market NY initiative to promote New York products; 10 high-tech incubators where startups could develop free of the need to worry about business, property and sales taxes; and a $50 million Innovation Venture Capital Fund for startups.
Yet it's also striking what the governor did not include in his address. He did not explain how he would pay for the scores of proposals outlined in his State of the State. That presumably will come with his new budget plan.
But where was any mention of New York's enormous debt burden and the need to put the state on a sustainable fiscal course?
A couple of weeks ago we suggested that Mr. Cuomo ought to use the State of the State to speak frankly about these concerns. In the meantime, Comptroller Thomas DiNapoli issued a report on New York's debt obligations that should be a wakeup call for anyone who has been looking the other way.
New York's outstanding debt averages $3,253 for each resident. Its state-funded debt of $63 billion is second only to California's and 80 percent higher than New Jersey's, which is third-highest.
Since fiscal year 2002-03, New York's debt has soared $24.3 billion-a 62 percent increase.
New York pays nearly $7 billion annually in state-funded debt service. Meanwhile, critical needs such as infrastructure repairs are not addressed, and New Yorkers continue to shoulder the heaviest state and local tax burden nationwide.
This is not to say Mr. Cuomo has done nothing to reform New York's fiscal affairs; he has made considerable strides. But even at 300-plus pages, his State of the State does not give the full picture.
1/4/13 (c) 2013 Rochester Business Journal. To obtain permission to reprint this article, call 585-546-8303 or email email@example.com.

subset: commoncrawl


text:
Ann Christophersen, co-owner of Women and Children First bookstore in the Andersonville neighborhood, turned to Linda Bubon, her longtime business partner and scowled at the table that had been set up on a riser at the back of their store. The actress Jane Lynch was due in a few minutes. She was there to sign copies of her new memoir, "Happy Accidents." This was Sunday afternoon, and several hundreds of fans of Lynch, who grew up in Dolton and plays the mean-spirited gym teacher Sue Sylvester on "Glee," were waiting outside.
"Nobody thinks this is a good idea," Christophersen said, meaning having the table on the riser, meaning customers would have to take a step up before having a book signed.
"I never thought it was a good idea," Bubon said.
"Suggestion?" said Kathie Bergquist, an employee. "Don't put anything on stage."
"Yes," said another employee, "but the stage keeps people from standing behind Jane."
As they talked, red tape was stretched across the floor, creating impromptu aisles to organize the impending crush of customers. Bubon and Christophersen wore matching black-and-white tracksuits and carried whistles, nods to Sue Sylvester. Outside, on the sidewalk, the store had erected speakers so fans unable to get in could listen to Lynch's remarks. Lampposts and trees were marked with numbers to help organize the crowd into numerical clusters. Brent Perrotti, 26, held onto marker No. 145.
He stood patiently and read Lynch's memoir and waited for his mother, who was meeting him. He explained, like many others in line, that Lynch was an inspiration to the gay community: "To see someone out and successful makes you feel not so alone."
Indeed, a day earlier, seated in a quiet backroom in the basement of a Barnes & Noble in Skokie, just before another book signing, Lynch explained that she didn't tell her parents she was gay until she was in her 30s, and that she had an idea how her life would be, "and in that life I wasn't gay and I wasn't an alcoholic." The point of the book, to some extent, "was to write a letter to my 20-year-old self, who was so afraid and full of anxiety, and tell that person to relax. Our circumstances may not line up," she said, referring now to her readers, "you might not have grown up on the South Side and been raised in an Irish Catholic family, but you don't need to be anywhere other than where you are, at this moment, now."
Heartwarming, uplifting sentiments about relaxing aside, it must be said: Jane Lynch is a model of efficiency — streamlined, sharp and no-nonsense. She spoke in the same quick, rapid sentences of Sue Sylvester. She wore a long, tan leather jacket, the kind a tough TV cop might wear. And no doubt, though appreciative of her admirers, Lynch herself had to admire the methodical nature of her Women and Children appearance. She said she just had lunch at Ruby Tuesday's in Skokie with her mother, who still lives on the South Side. After that, she crossed the street and signed at Barnes & Noble. After that, she left for Unabridged Books in Lakeview, to sign more books; then she had coffee with a friend. "I work fast," she said. "Laser focused! I'm like that with everything. I do something, I want to be done with it."
She hates disorder. She can no longer own throw pillows: "Too messy, too frivolous."
As she arrived at Women and Children on Sunday, the line of people waiting to meet her started at the front door of the bookstore, on Clark Street, then stretched around the corner and headed down Farragut Avenue. She had just been at the taping of an episode of "Windy City Live." As her car turned in to the parking lot behind the store, it drove past Carol Cheney, who went to high school with Lynch and clutched their yearbook from 1978. Cheney said she directed Lynch in a school production of "Godspell." She was carrying with her a letter for the actress: "It's three pages, but I didn't know how to get in touch with her anymore."
Inside the store, questions flew: Were her lines in "Best in Show" written or improvised? (Improvised.) What actor did she most want to work with? (Carol Burnett and Olivia Newton John) Do you feel any backlash for being a lesbian? ("Not unless it's behind my back.") Is there really a "Velvet Mafia" in Hollywood? ("Is that a gay thing? Do they have a potluck?") Do you have advice for a 20-year-old? ("Say yes to everything but porno.")
The crowd was asked not to step around the table or touch Lynch. She would take pictures with fans while seated, from across the table. This kept the line moving, plus, as Christophersen said: "Would you want to be touched by 500 people?"
Having had their books signed, Lisa Martin and Vicki Kenyan, both from Chicago, and both of whom have been in a relationship together for the past 10 years (and who also recently made it official with a civil union), stood apart from the line, inspecting the pictures they took with Lynch. In the photographs, both parties stood a respectful, tabletop's length apart. "It's incredible how much of a role model she is," Martin said. "She came out later in life, was uncertain of who she was. She means a lot to people."
"It's also nice to see someone like this happy," Kenyan said.
"And that it's been financially rewarding to her," Martin said.
"I really believe that the more positive images of lesbians there are in the media," Kenyan said, "the more that people just don't give any of this a second thought."
Lynch signed books for three hours, then she left for O'Hare International Airport, where she signed more books. Then she flew back to Los Angeles, where she was having a niece's rug washed first thing Monday morning. She stayed pragmatic and on schedule.
Twitter @borrelli
Ann Christophersen, co-owner of Women and Children First bookstore in the Andersonville neighborhood, turned to Linda Bubon, her longtime business partner and scowled at the table that had been set up on a riser at the back of their store. The actress Jane Lynch was due in a few minutes. She was there to sign copies of her new memoir, "Happy Accidents." This was Sunday afternoon, and several hundreds of fans of Lynch, who grew up in Dolton and plays the mean-spirited gym teacher Sue Sylvester on "Glee," were waiting outside.


text:
Our blog will be updated regularly with information about school events, lots of examples of our children's learning and also additional work and support for children at home. Our class blogs provide our children with a real audience and purpose for writing.
Please feel free to comment and give us feedback on any of our posts. Your comments will be monitored before going live and then will be shared with the children.


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Look on the back of any modern book and you will find an ISBN code. Take this code and calculate this sum in the way shown. Can you see what the answers always have in common?
On a calculator, make 15 by using only the 2 key and any of the four operations keys. How many ways can you find to do it?
Number problems at primary level that may require resilience.
On the planet Vuv there are two sorts of creatures. The Zios have 3 legs and the Zepts have 7 legs. The great planetary explorer Nico counted 52 legs. How many Zios and how many Zepts were there?
Number problems at primary level to work on with others.
I throw three dice and get 5, 3 and 2. Add the scores on the three dice. What do you get? Now multiply the scores. What do you notice?
Find another number that is one short of a square number and when you double it and add 1, the result is also a square number.
Can you substitute numbers for the letters in these sums?
Rocco ran in a 200 m race for his class. Use the information to find out how many runners there were in the race and what Rocco's finishing position was.
Ben's class were cutting up number tracks. First they cut them into twos and added up the numbers on each piece. What patterns could they see?
Try adding together the dates of all the days in one week. Now multiply the first date by 7 and add 21. Can you explain what happens?
Can you draw a continuous line through 16 numbers on this grid so that the total of the numbers you pass through is as high as possible?
48 is called an abundant number because it is less than the sum of its factors (without itself). Can you find some more abundant numbers?
There are three buckets each of which holds a maximum of 5 litres. Use the clues to work out how much liquid there is in each bucket.
Put the numbers 1, 2, 3, 4, 5, 6 into the squares so that the numbers on each circle add up to the same amount. Can you find the rule for giving another set of six numbers?
Fill in the missing numbers so that adding each pair of corner numbers gives you the number between them (in the box).
There are 44 people coming to a dinner party. There are 15 square tables that seat 4 people. Find a way to seat the 44 people using all 15 tables, with no empty places.
I was looking at the number plate of a car parked outside. Using my special code S208VBJ adds to 65. Can you crack my code and use it to find out what both of these number plates add up to?
Peter, Melanie, Amil and Jack received a total of 38 chocolate eggs. Use the information to work out how many eggs each person had.
Zumf makes spectacles for the residents of the planet Zargon, who have either 3 eyes or 4 eyes. How many lenses will Zumf need to make all the different orders for 9 families?
Make a set of numbers that use all the digits from 1 to 9, once and once only. Add them up. The result is divisible by 9. Add each of the digits in the new number. What is their sum? Now try some. . . .
Start by putting one million (1 000 000) into the display of your calculator. Can you reduce this to 7 using just the 7 key and add, subtract, multiply, divide and equals as many times as you like?
There are 78 prisoners in a square cell block of twelve cells. The clever prison warder arranged them so there were 25 along each wall of the prison block. How did he do it?
On the table there is a pile of oranges and lemons that weighs exactly one kilogram. Using the information, can you work out how many lemons there are?
Can you put plus signs in so this is true? 1 2 3 4 5 6 7 8 9 = 99 How many ways can you do it?
This magic square has operations written in it, to make it into a maze. Start wherever you like, go through every cell and go out a total of 15!
There are 4 jugs which hold 9 litres, 7 litres, 4 litres and 2 litres. Find a way to pour 9 litres of drink from one jug to another until you are left with exactly 3 litres in three of the jugs.
Can you score 100 by throwing rings on this board? Is there more than way to do it?
Using 3 rods of integer lengths, none longer than 10 units and not using any rod more than once, you can measure all the lengths in whole units from 1 to 10 units. How many ways can you do this?
There is a clock-face where the numbers have become all mixed up. Can you find out where all the numbers have got to from these ten statements?
Cassandra, David and Lachlan are brothers and sisters. They range in age between 1 year and 14 years. Can you figure out their exact ages from the clues?
Place the digits 1 to 9 into the circles so that each side of the triangle adds to the same total.
Tell your friends that you have a strange calculator that turns numbers backwards. What secret number do you have to enter to make 141 414 turn around?
What is happening at each box in these machines?
You have 5 darts and your target score is 44. How many different ways could you score 44?
Winifred Wytsh bought a box each of jelly babies, milk jelly bears, yellow jelly bees and jelly belly beans. In how many different ways could she make a jolly jelly feast with 32 legs?
There were chews for 2p, mini eggs for 3p, Chocko bars for 5p and lollypops for 7p in the sweet shop. What could each of the children buy with their money?
A group of children are using measuring cylinders but they lose the labels. Can you help relabel them?
Where can you draw a line on a clock face so that the numbers on both sides have the same total?
This problem is based on the story of the Pied Piper of Hamelin. Investigate the different numbers of people and rats there could have been if you know how many legs there are altogether!
Mrs Morgan, the class's teacher, pinned numbers onto the backs of three children. Use the information to find out what the three numbers were.
The Scot, John Napier, invented these strips about 400 years ago to help calculate multiplication and division. Can you work out how to use Napier's bones to find the answer to these multiplications?
The clockmaker's wife cut up his birthday cake to look like a clock face. Can you work out who received each piece?
Here are the prices for 1st and 2nd class mail within the UK. You have an unlimited number of each of these stamps. Which stamps would you need to post a parcel weighing 825g?
Use your logical-thinking skills to deduce how much Dan's crisps and ice-cream cost altogether.
Annie cut this numbered cake into 3 pieces with 3 cuts so that the numbers on each piece added to the same total. Where were the cuts and what fraction of the whole cake was each piece?
Find out what a Deca Tree is and then work out how many leaves there will be after the woodcutter has cut off a trunk, a branch, a twig and a leaf.
EWWNP means Exploring Wild and Wonderful Number Patterns Created by Yourself! Investigate what happens if we create number patterns using some simple rules.
If the numbers 5, 7 and 4 go into this function machine, what numbers will come out?
This task, written for the National Young Mathematicians' Award 2016, invites you to explore the different combinations of scores that you might get on these dart boards.


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When cancer is in the spotlight, we usually hear about fundraising walks, research on new treatments or other efforts aimed at finding a cure. We rarely hear about environmental causes of cancer. According to Devra Davis, author of 'The Secret History of the War on Cancer,' this is no accident.
In this interview, Dr. Davis criticizes the chemical industry, reviews the science of how environmental toxins cause cancer and discusses what might be done to prevent cancers from environmental causes.
Epidemiology 101: Natural Experiments in Cancer Prevention
Dr. Davis:
Like a lot of words, 'epidemiology' comes from two Greek words, epi meaning upon, and demos, meaning the people. It's the study of the patterns of health and disease among the people in time and space. So we look at the way disease happens. We look for clues from the patterns in disease to identify things that cause it and things we can do to prevent it or cure it more easily.
The best, well-controlled design that we can do is the case-controlled study where we randomly assign people to have a drug and compare the people who got the drug to those who did not get the drug. Unfortunately, in the real environment, we don't have such a luxury. People are exposed to many things often at the same time, and in the real world we don't have the elegance of the controlled trial that we do with drugs. That makes it very difficult to understand the causes of cancer from epidemiology.
That's why in my book ('The Secret History of the War on Cancer') I argue that we've got to be smarter about taking lessons from natural experiments that have occurred through disasters, such as Chernobyl or Hiroshima, or disasters that occurred in the past with the kinds of occupational exposures that men and women had working in factories with asbestos and benzene and other things like that. But we've also got to use experimental information where we have it so that we don't insist that the only proof that something causes cancer in humans is epidemiologic studies, and we rely on experimental models and clinical case reports as well. It's very, very complicated to do good epidemiology in the environment because the environment is necessarily messy and complicated.
Exposing the Secrets Surrounding the War on Cancer
Dr. Davis:
I first tried to write 'The Secret History of the War on Cancer' about 20 years ago, and I had some offers of a book contract, actually. My boss at the time said to me, 'It had better be a good book.' I didn't quite understand what he was getting at, and I said, 'Well, I think it will be. They are offering me a very handsome advance.' He said, 'No, if you are going to write a book critical of the cancer enterprise, - and remember this was the beginning of the Reagan revolution - you are free to write it, but you won't have a job here when you finish.'
At the time, I was working at the National Academy of Sciences. My boss is actually a very smart man, and what he was telling me was that given the politics of the time it wouldn't be possible for me to remain at a place like the National Academy of Sciences having written a book that said basically that for much of our effort we've been fighting the wrong war against the wrong enemies with the wrong weapons. Because what I was going to say then and what I have said now is that we started the war against cancer in 1971 officially. We knew that seven years earlier the surgeon general had issued a report saying that tobacco smoke caused lung cancer and other diseases, and yet the war on cancer starts, and it's completely silent about tobacco. It's completely silent about other things that scientists understood caused cancer at the time, including benzene, including asbestos.
So the fact that we started to fight the disease and improved our methods of finding it and treating it but ignored the things that we knew caused it was what I really was concerned with documenting. Now the world is a little different, and I've been able to do that, and I am very glad to have people like you paying attention to it.
Few Incentives Exist for Cancer Prevention
Dr. Davis:
I think we have made tremendous progress. We have 10 million cancer survivors, but, as you know, 1 million of them are under age 40. That's a credit to our ability to find and treat cancer, but it's also an indication that something is terribly wrong when we see so many young cancer survivors. We have young cancer survivors because we have gotten better at treating cancer in young people, but sometimes the things we treat people with can cause other cancers later on. For example, young women who are treated for Hodgkin's disease with mantle radiation to the lymph glands in the chest, unfortunately, if they have been treated before age 16, by age 40 one in three of them will have breast cancer.
In fairness, I think in the beginning of the war on cancer, there was a certain naivete. President Nixon was told by some people that by the American bicentennial, 1976, they would have a cure for cancer. That looks ludicrous, of course, nowadays. So there was a great deal of optimism that was the willing suspension of disbelief on the part of some people who wanted to believe that we would be able to just very easily give people a pill for cancer. And if we did that, then we would be able to continue smoking and using asbestos and other things. But, in fact, there is a lot of money now that's invested in treatment and finding cancer, a direct cost of a hundred billion dollars a year just on cancer treatment alone.
There is a paradoxical set of incentives here because some companies that are very large have divisions that make cancer-causing products, such as pesticides and toxic chemicals, and other divisions that make drugs to treat cancer. So, in a sense, they have it both ways. I don't think there is anyone sitting at the top of such companies saying, 'Well, gee, we better make sure we generate enough cancer here so we have enough revenues to treat it,' but that's one of the paradoxes of the complex world in which we live right now. So the incentives, in a sense, are not particularly well-organized to discourage the existence of cancer, and I think we've got to change that now by creating incentives to prevent the disease.
The Cancer Risks of Tobacco Were Hidden for Decades
Dr. Davis:
Some scientists in the 19th century, pathologists who did detailed clinical evaluations at autopsies of the lungs of people who were cigarette smokers who had been prominent men who did not work in factories, reported that the lungs of cigarette smokers were black. They warned in the 19th century that tobacco clearly caused cancer and other diseases.
They were pretty much ignored, but in the 1930s there was research done in Germany and also in Argentina and Japan that showed that smoking caused lung cancer and other problems. There was an institute in Buenos Aries, Argentina, headed by Angel Honorio Roffo, and he did work on the dangers of tobacco. He also showed the dangers of sunlight and its ability to induce cancer in rodents, and he showed in 1936 that if you combined exposures to sunlight and hydrocarbons, like some of the hydrocarbons we get out of tobacco, that you got a greater cancer response in animals. So there was an amazing amount of evidence that I have unearthed in researching this book that in the 1930s scientists understood that cigarettes caused cancer.
Ironically, it was the Germans that developed the first official research institute on tobacco and demonstrated in a design that looks incredibly modern by today's standards that men and women who smoked tended to have a much higher risk of lung cancer and of other cancers. In fact, Germany had a very schizophrenic approach to smoking because while they depended on the revenues from tobacco, as did many nations already at that time, Hitler tried to outlaw smoking and actually forbade women of reproductive age from smoking. The Nazis actually promoted organic agriculture and the development of organic agriculture, understanding that synthetic materials might be dangerous.
There is clear evidence that the dangers of tobacco were well-known for a long time, well before the 1950s, and by 1950 there was no longer any debate about it.
The American Cancer Society (ACS) itself went through a very wrenching period because their scientists did research that showed that tobacco clearly was causing cancer in the 1950s, but Cuyler Hammond (director of statistical research at the American Cancer Society from 1952 to 1954), one of the brave and brilliant scientists from the American Cancer Society, was threatened with personal financial ruin if he released his results on the dangers of tobacco. You have to remember the ACS was run by people who smoked and people who profited from smoking. So the heads of the major advertising companies that started the Cancer Society did not want it to take a position on tobacco. To their credit, the ACS is now one of the most effective anti-tobacco groups in the world, but they delayed becoming that for some time. The American Medical Association actually procrastinated even longer.
Corporate Interests Shift Focus Away from Cancer Prevention
Dr. Davis:
The tobacco industry did something that has been done more recently by the chemical industry. They understood that the most effective PR in the world appears as independent scientific information. So what they did is they took out a full-page ad, called, 'The Frank Statement,' in the New York Times that appeared in many other major publications and sent it to all members of Congress. It appeared to be an authoritative scientific analysis that explained in great detail why the evidence on tobacco was not conclusive, why it would be premature to presume that people ought to reduce smoking based on what was known at the time.
Now, the brains behind the tobacco industry's Frank Statement is a very interesting guy named Clarence Cook Little. Dr. Little was a brilliant geneticist, and he actually founded the Jackson Memorial Labs, which are still known for their ability to breed unique mice that are genetically well-suited to research on cancer. He left the American Cancer Society in 1954 to become the director of the Tobacco Industry Research Council.
In that position, he helped write statements like that one and established blue ribbon research committees to argue that distinguished medical authorities indicate it will take years before we can reach any agreement about cigarette smoking and its effects on people's health. They assured people that it's been 300 years of safe use, solace, and relaxation and enjoyment to mankind from tobacco. The statement was signed by some of the most eminent scientists in the nation at the time.
The Tobacco Industry: Setting the Mold for Chemical Companies
Dr. Davis:
The tobacco industry really sets the mold and others have adopted it. Examples that I talk about in my book include the fact that some prominent epidemiologists for years secretly worked for the vinyl chloride industry, for the benzene industry, manufacturing uncertainty (about the cancer causing properties of those products) and never telling any of their colleagues that they were being paid to do so.
For example, in 1986 Sir Richard Doll, who is one of the most eminent epidemiologists in the world, a man credited with having brought the Western world to understand the dangers of smoking, published an article suggesting that vinyl chloride was less dangerous than the World Health Organization had said that it was several years earlier. Now, Richard Doll was really a giant in the field the public health. The fact that he published this analysis suggesting that the World Health Organization was wrong was treated very seriously.
But think about what was happening in 1986 in the United States. There was really a real interest in deregulating and in pulling back from organizations like the Occupational Safety and Health Administration, which was charged with regulating vinyl chloride. When Richard Doll wrote on this subject, he was being paid $1,500 a day by the chemical companies.
The ability to attract people who were giants in the field and get them to weigh in on issues of this sort with very narrow questions in epidemiology has been quite appalling, because the question that many of these epidemiologists will answer is, 'Do you have proof of human harm?' The question is framed in a very narrow way where proof of human harm means statistically significant numbers of people with proven histories of exposure to unique chemicals under specific circumstances that have caused specific tumors. If proof is defined in such a very narrow way, we seldom have that proof.
So my position in my book, 'The Secret History of the War on Cancer,' is that we have got to stop making sick or dead people the requirement for proof to prevent future harm. We have to recognize that epidemiology is a really important tool that confirms the past but cannot be used to predict the future.
How Trade Secrets Put People at Risk of Developing Cancer
Dr. Davis:
What I document in the book is that it was perfectly legal for companies to keep information on the dangers of their products away from their workers. There is a history of doing this with asbestos, with benzene, with vinyl chloride, where workers were the last to know about the dangers that the companies were aware of. For example, when the vinyl chloride industry first discovered that there was a strange thing happening to their workers with stubbing of fingers, a strange defect of fingers getting stubbed which reflected the exposure to vinyl chloride, they began a secret study internally and didn't tell their workers about it.
Vinyl chloride can be used to make pipes in our homes. Polyvinyl chloride can be used as well in Lexan, which is used for the water bottles that have the number 7 on them, things that are very, very hard plastic. It's made out of polymerization of vinyl chloride gas, but it also when it burns can release dioxins at high temperatures. There is a national and international movement to phase out the use of polyvinyl chloride pipes in construction right now, and many European nations have banned it and are phasing it out. It's the kind of thing where exposure could have taken place 20 or 30 years earlier and lead to a very rare cancer of the liver called angiosarcoma.
Unfortunately, a trade secret may be something that explains why my father died or why somebody else's father gets sick. There is a sense that companies, of course, are entitled to make profits, and there is a very gray line between what they are allowed to call a trade secret. That's why I call in the end for a re-thinking of the approach to confidentiality and for a truth and reconciliation commission where companies would come forward with what they know about the hazards of materials they are using now. If they did that, they would then not have any punitive damages held against them, but they would accept responsibility to pay for the healthcare cost of workers and communities affected by things that they know about.
I know that companies have information in their files, because many of them are self-insured now, about hazards of the things that people work with, but we have no way to get that information. There is no incentive for them to disclose it. The current system is very adversarial, and the harder we use it the less we are likely to get information to come out.
Quite frankly, one of the most important things you can do to avoid having to become chemists to go shopping is to vote. I think it's outrageous in the United States today that we don't know whether or not there are carcinogens in our baby's bubble bath or shampoo. We have no protection against that. Dioxane is one example of a chemical that we know causes cancer in male and female rats and mice that is banned in Europe. You can't find it in European bubble bath or shampoo but we can in ours.
In the book, I go into detail about the things you can look for to know whether or not a product contains these things, but it seems to me that we need to change the way the government acts, and the private sector has to step up to the plate and accept more responsibility here. Frankly, we are going to lose our edge competitively in the world of chemicals and cosmetic products if we have looser standards in the United States than they do in Europe, and that is the case right now.
Should Doctors Reduce Their Use of Diagnostic Radiation?
Dr. Davis:
These new technologies do save lives. They reduce the need for exploratory surgery, for example. But the American College of Radiology has recently warned about the excessive use of diagnostic radiation, particularly in infants and children. I agree with them, because a CT scan of the head of a child, especially of a baby, can be between 200 to 6,000 chest X-ray equivalents. Now, if you have an unconscious child with a head wound, the child may need a CT scan, but these scans are being used in a lot of circumstances where it's not life-threatening, and I agree that we are going to be creating problems because of this. Because we know, as I said earlier, that radiation to a young child increases their risk of developing cancer later on.
There is no question there is a real increase in cancer in the young. In fact, testicular cancer has increased by at least 50 percent in every industrial country. We have a million cancer survivors now that are under the age of 40. One of the things I am concerned about is whether the excessive use of diagnostic radiation in healthy people might be contributing to the increased cancers that we are seeing in young people. It's not just in the United States. It's in many other countries.
There are tremendous opportunities in treatment and the ability to use the immune system, but we still need to prevent cancer from happening in the first place. We still need to figure out why more young people today are getting cancer and why they are getting more serious cancer.
More Information About Environmental Cancer Risks
If you'd like to hear more about the history of the war on cancer and what you can do to reduce your exposure to cancer-causing environmental toxins, listen to the entire webcast of Our Toxic World: The Real Cancer Battlefield and hear how Dr. Davis answered questions from the audience.
For more information on environmental cancer risks, check out these other HealthTalk resources:


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The last time you cried.....
Moderator: Big-Will
The last time you cried.....
I'm not really a crying person so the last time I cried I was about 9 or 10. I was having a water balloon fight with my cousins and I saw some people walking down the road. So I climbed up onto wall and started throwing water balloons at them. Unluckily there was a brick loose in the wall. I stood on it, slipped and landed on the barbeque (thank god it wasnt on). A spike of metal went into my leg so it hurt. A lot. And I cried. I've still got the scar
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She is over right now.And, probably staying over tomorrow night too. Goody for me.I really f*cking wish tomorrow wasn't one of my days off from work..I am not going to cry this time about her not even acknowledging my existence..No, I am going to find some way to annoy her without looking like I am doing anything. Revenge is so very, very sweet..
I am surprised I managed to cry about this situation..Usually, when something really really hurts, I don't cry..I just push the painful feelings back. Or find someway to deny that the situation that hurt me even happened.That is not healthy, I know. Maybe it is the only way I feel that can handle some of the things that have gone wrong in my life. By not thinking about them, which is bad, because doing that insures that I will never get over them.
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Weird people make no sense.
Poor people make no cents.
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DO NOT click this.You don´t understand it anyway.
M00ndragon69´s husband
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We safely got back home, but while we were home, we had some more wine and my brother and I started getting emotional because of the music he was playing and because of sharing our fears together.
I cried in my father's arms that night because of his words of comfort. I honestly have a fear of failure. Everyone in my life sees me as a very intelligent person who takes challenges head on and seeing them seeing me fail is sometimes the hardest thing I have to face.
When I screwed up my college career in 2003 because of personal demons, I took it really hard because of how disappointed my family was with me. I'm *NOW* coming back to school this summer to raise my GPA and repair my screwups so I can earn my degree and start a new chapter in my life.
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Wanting to kill that woman is something natural. That is a healthy reaction. If you felt differently for any reason, religious or otherwise, then something is wrong with you.
What culture has done to you has unfortunately turned you into a hypocrite.When you suspect unfaithfulness, you are bound to be tortured by jealousy, by hate and by the agony that is going on inside you.If you can make it possible without going mad, good luck to you!
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She's doing okay now. She just had her liver worked on and is feeling great. In fact, she's looking forward to seeing me soon.
I better end it right there before I go all gooey again...
AngusArt updated 4/9/17.
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HesseldeBoer wrote:M00ndragom69.
Wanting to kill that woman is something natural. That is a healthy reaction. If you felt differently for any reason, religious or otherwise, then something is wrong with you.
What culture has done to you has unfortunately turned you into a hypocrite.When you suspect unfaithfulness, you are bound to be tortured by jealousy, by hate and by the agony that is going on inside you.If you can make it possible without going mad, good luck to you!
Umm, I don't want to kill her..Then she wouldn't learn anything..No, I want to really, really piss her off, expose her to everyone for what a bitch she really is ( which I pretty much already am doing, I am not the only friend she has been treating like sh*t), and put her in a position where she feel sad lonely and rejected..Then send her a cruel email, telling her that she got what she deserved, and that she is a not the nice person she wishes she was, and that she is a backstabber and a phony.. That would hurt her more than killing her, because she would once again be confronted with the knowledge that she isn't the great person she imagines herself to be.
She once told me that when she was a kid, she went around being mean to people..She played mind games on people and such..Then, one day, some of her peers confronted her, called her mean, and it upset her so much that she changed into this people pleaser who did and said anything she thought other people wanted..This was years before she and I met..When she told me the story, I just figured what she was describing was the normal f*cked up things kids do.Like what we see on South Park, alot of kids are mean little bastards but they learn better when they grow up. So, when she told me this, I told her, she was just a kid and she probably wasn't that bad..But, I guess this sh*t was more than her over reacting to her embarrassment of how she was as a kid..No what she writes in her live journal confirms that the her I had gotten to know and love didn't exist, and now that she is being more like she really is, she is being a total bitch, and hurting me and other people I care about. It was obvious she didn't learn anything from being confronted about her meanness in the past, she only cared to change for awhile, because she didn't want people to think badly of her.. For me, that isn't enough. No, she has to know why how she treats other people is wrong, and learn to have some f*cking empathy for others.
By the way, if you think about it, everyone is a hipocrit at some point. Everyone contradicts themselves at some point in their life time.. And, if you hear the word HIPOCRIT or see it appear on the board enough in a short period of time, that word looses its power.
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1318.3 - Qld Stats, Mar 2008
ARCHIVED ISSUE Released at 11:30 AM (CANBERRA TIME) 20/03/2008
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The number of owner occupied housing commitments in trend estimate terms decreased by -0.7% to 14,679 in January 2008 when compared with January 2007. There was also a small decrease (-0.1%) between December 2007 and January 2008, the eighth consecutive monthly decrease following 15 consecutive months of increases.
The trend estimate of the total value of housing finance commitments for owner occupation in Queensland has risen by 5.8% to $3,489 million in the 12 months to January 2008. In terms of the trend estimate, the value of housing finance commitments showed a slight decrease of -0.6% from December 2007.
Since January 1998, the average home loan commitment for owner occupied dwellings in Queensland has more than doubled from $107,400 to $239,800.
In January 2008, the average loan size for first home buyers ($238,400) was marginally lower than for non-first home buyers ($240,100)
Further information on this topic is available in Housing Finance, Australia (cat. no. 5609.0) or ring the National Information and Referral Service on 1300 135 070. This publication is released monthly.
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JUPITER, Fla., Aug. 19 (UPI) -- A man believed to be a contractor was found dead Monday at singer Olivia Newton-John's home in Florida, said police who labeled it an apparent suicide.
Jupiter police Sgt. Scott Pascarella said Newton-John and her husband, John Easterling, were not in the house when the body was found, The Palm Beach Post reported. The man, 42, whose identity had not been released, was believed to be working for the couple as a contractor.
Pascarella said the man died of a gunshot wound. He said the death appeared to be a suicide but the investigation remained open.
Newton-John, 64, born in England and raised in Australia, is a four-time Grammy-winning pop and country singer. She starred with John Travolta in the movie version of "Grease."
Her house is in Jupiter Inlet Colony, a tiny upmarket coastal town. The house is reportedly under contract to Rosie O'Donnell, who recently sold her Miami mansion.


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Target 4. Eliminate gender disparity in primary and secondary education, preferably by 2005, and to all levels of education no later than 2015
Goal 3. Promote gender equality and empower women
C - Country Data. The figure is the one produced and disseminated by the country (including data adjusted BY THE COUNTRY to meet international standards)
E - Estimated. The figure is estimated by the international agency, when corresponding country data on a specific year or set of years are not available, or when multiple sources exist, or there are issues of data quality. Estimates are based on national data, such as surveys or administrative records, or other sources but on the same variable being estimated.
Source: United Nations Statistics Division - Unless otherwise noted, information in this page is accurate as of February 15, 2007


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REDMOND, Wash. — "Your mileage may vary" ... That old phrase is even more relevant for the newfangled Nissan Leaf electric vehicle, which has an advertised range of 100 miles on a charge. In fact, the mileage depends quite a bit on your driving style, and the numbers can go up and down in the course of a drive.
Yes, it's possible to get 100 miles or more from the Leaf. But if you're the kind of guy who keeps the car on the road even if the needle is near the "E" mark, you might have to change your ways.
The "needle" on the Leaf isn't a physical needle, but a readout that appears right in front of the driver on the dashboard, as well as on the energy-monitoring displays you can bring up on the center console's touchscreen. You can even bring up a map with two concentric circles, estimating how far you can go in normal mode (in which the Leaf acts pretty much like a normal car) and in eco-mode (which tweaks the car's response to optimize the power savings).
To arrive at those estimates, the Leaf's electronic brain factors in how you've been driving the car up to that point, as well as the load that's being put on the electric motor at that moment. When you're coasting downhill, you can actually add to your range.
Luxury in a Leaf
Let's take my drive through Western Washington's Issaquah Alps as an example. The first seven miles were so effortless that the range went up from 96 to 103 miles in eco-mode. But that was the day's high mark: As multimedia editor Jim Seida and I drove up through the mountains, the numbers were driven down. At the 19-mile mark, when we passed by Snoqualmie Falls (where the TV show "Twin Peaks" was filmed), the Leaf's screens told us we had only 45 miles of driving left.
Power up! More about electric vehicles
Come along on an electric road trip
Science editor Alan Boyle's Weblog: Trace our trips in the all-electric Nissan Leaf as well as the Chevy Volt.
- Electric car wave offers opening to startups
- GE to buy 25,000 electric cars by 2015
- Toyota chief showcases Tesla friendship
- Come along on an electric road trip
Those numbers quickly crept up again during our descent from the mountains — back to a range of 60 miles. But we lived a little too luxuriously on the way back: Turning on the heater and the fan ate into our electrical reserve, and by the time we returned to Redmond, we had an estimated 24 miles left in the batteries. A 47-mile trip took away 72 miles of my original estimated range. Good thing we didn't go all the way to Snoqualmie Pass (which would have been a 100-mile round trip).
If we were true hypermilers, we would have been able to get by with less electricity — but instead, we drove the Leaf like a normal car. The bottom line is that Leaf drivers will have to think about their driving strategy: If a visit to the neighborhood grocery store is your only stop of the day, there's nothing to worry about. If you have a 25-mile commute to work, and you have to stop back at home before going out to an evening engagement that's 5 miles away, you just might be thinking about charging up while you're at work and using the eco-mode setting.
Guilty as charged?
Speaking of charged up, I received some sharp comments about the fact that I topped off the Leaf's batteries on Monday by plugging into an outlet at the office parking garage.
"The main problem is you are stealing someone else's electricity," one commenter wrote.
Another writer was critical of the whole electric-vehicle concept: "When that big 4x4 is blocking you in, it will be me. The hand waving you forward will have an extended middle finger. Just for you EV elites."
NBC Green Week
Such responses show that the move toward "electrification" of the automotive industry could run into a few culture clashes along the way. What principles will find their way into electric-car etiquette, or corporate and governmental policies?
I'd like to think that places like the Oregon city of Hillsboro (where Intel is the largest employer) are leading the way in the creation of charging-station havens. I'd like to think that the EV Project, which is due to install 15,000 charging stations over the next year with $115 million in support from the U.S. Department of Energy, is on the right track. But for some people, having taxpayers foot the bill for the installation of charging stations would be going too far.
The way I see it, the success of the Leaf will depend on the spread of those charging stations — not so much because they're necessary, but because that will reassure folks like me that there's a backup plan just in case the Leaf sometimes doesn't go as far as you expect it to.
You can try the Leaf out for yourself during the "Drive Electric Tour," sponsored by Nissan. The next stop is in San Francisco. Keep checking our Green Innovation section for more about electric cars and our "Electric Road Trip."
Connect with the Cosmic Log community by "liking" the log's Facebook page or following @b0yle on Twitter. You can also check out "The Case for Pluto," my book about the controversial dwarf planet and the search for new worlds.
© 2013 msnbc.com Reprints


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grabaseat™ fares
grabaseat™ fares are our lowest fares for travel within New Zealand. These fares sell out quickly so book well in advance to find these low fares.
Terms and conditions
- Fares may be changed up to the day before departure to another Air New Zealand Domestic fare. Additional payments include:
- Through a Contact Centre or airport, a service fee of NZD $30 per person, per one-way journey applies. No service fee applies to changes made online*
- a change fee of NZD $50 per person, per ticket (infant fares exempt)
- any difference between the original fare and the upgraded fare when a change requires the purchase of a higher priced fare
Note: changes to limited life sale fares once sales have expired are only permitted by paying the difference to upgrade to a higher class fare plus the change fee of NZD $50.
- If you upgrade to a flexidate fare and later cancel the ticket, only the difference between the original fare booked and the upgraded fare is eligible for refund
- Tickets are non refundable
- Full refund of unused tickets in the event of death of the passenger or his/her immediate family or any person booked to accompany the passenger
- Name changes are not permitted
- grabaseat™ fares booked in F class do not permit:
- earning of Airpoints Dollars™ with Air New Zealand or other frequent flyer points or miles with any of our partner airlines, however they do earn Status Points1
- Seat request. Your seat(s) will be allocated at the airport before departure (when seat changes may also be requested). Airpoints Gold, Elite and Koru members may seat request as normal
- purchase of Companion Tickets using Airpoints Dollars
- Child discounts do not apply
- One infant (0-23 months) not requiring a seat may travel with each adult at the infant fare level (free of charge for domestic New Zealand flights), with subsequent infants travelling at the applicable adult fare level
- grabaseat™ fares are one-way and may be combined with other fare types as follows:
- may only be combined with other domestic New Zealand fares
- may not be combined with international fares
- Bookings made online do not incur booking service fees. Please note that bookings made through an Air New Zealand Contact Centre or via Tandem Travel will incur a booking service fee calculated per person each one-way journey
* Online changes available if original booking is made online and must be completed at least 24 hours prior to departure. Bookings made through our Contact Centre may also be changed online. Please note - not all bookings are able to be accessed online.
¹ Flights booked in conjunction with travel industry classes and free tickets, prize competition tickets and tickets purchased using Airpoints Dollars or Fly Buys points are not eligible to earn Status Points.


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All News Releases By Date
Spokane Tribe to receive EPA Smart Growth assistance
Release Date: 03/12/2012
Contact Information: Abby Hall, EPA Office of Sustainable Communities, 415-972-3384, firstname.lastname@example.com; Tony Brown, EPA Public Affairs, 206-553-1203, email@example.com
Community of Wellpinit water and sewer system challenges addressed
(Seattle–March 12, 2012)) – The Spokane Tribe of Indians in eastern Washington will benefit from EPA technical assistance through the Smart Growth Implementation Assistance (SGIA) program. The Tribe will work with technical experts to address future water infrastructure needs in the community of Wellpinit, Washington.
The EPA funds private-sector experts through the EPA Smart Growth program to work with communities as they plan for future needs in ways that sustain environmental and economic progress and create a high quality of life. The Spokane Tribe requested assistance to support their development of a comprehensive water infrastructure plan that will focus on water and sewer system challenges in Wellpinit. The community faces future challenges of summer water shortages, drinking water delivery, pipe and pump failures, and design and maintenance of sewage management systems.
"Bringing private-sector consultants together with the professional staff of the Spokane Tribe will create a strong partnership to address future growth and the strains placed on older water systems," said Melanie Wood, Sustainable Infrastructure Coordinator in EPA's Pacific Northwest office. "These EPA Smart Growth programs not only provide support for environmental improvements, they also set the stage for green jobs and a healthier economy."
The EPA assistance builds upon a Housing and Urban Development Community Challenge Planning Grant the Tribe received in 2010. The water infrastructure plan will create a foundation for future housing, transportation, and economic development planning.
Since 2005 EPA has supported 31 SGIA projects, serving dozens of communities.
Smart Growth Implementation Assistance is a project of the Partnership for Sustainable Communities among EPA, the U.S. Department of Housing and Urban Development (HUD), and the U.S. Department of Transportation (DOT). The interagency collaboration coordinates federal investments in infrastructure, facilities, and services to get better results for communities and use taxpayer money more efficiently. The partnership is helping communities across the country create more housing choices, make transportation more efficient and reliable, reinforce existing investments, and support vibrant and healthy neighborhoods that attract businesses.
More information:
SGIA: https://www.epa.gov/smartgrowth/sgia2012.htm
Partnership for Sustainable Communities: http://www.sustainablecommunities.gov
Wellpinit community contact: Scott Radford, firstname.lastname@example.com/, 509-258-7100
Subscribe to automatically receive Region 10 News Releases via email at: http://service.govdelivery.com/service/subscribe.html?code=USEPA_C19
Search this collection of releases | or search all news releases
View selected historical press releases from 1970 to 1998 in the EPA History website.


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Jesus' Ascension Means We Are Never Alone, Pope Says
Pope Francis is continuing Benedict XVI's practice of reflecting on the Catholic statement of belief at his weekly general audiences as part of the Year of Faith.
VATICAN CITY — Pope Francis proclaimed "we are never alone" and that Jesus is our defender, as he reflected on the Ascension during his Wednesday general audience.
"We are never alone in our lives; we have this advocate who waits for us," the Pope told tens of thousands of pilgrims gathered at St. Peter's Square to participate in his April 17 audience.
The Pope centered his teaching on the line from the Creed that says, "He ascended into heaven and is seated at the right hand of the Father."
Pope Francis is continuing Benedict XVI's practice of reflecting on the Catholic statement of belief at his weekly general audiences as part of the Year of Faith.
"We are never alone; the crucified and risen Lord guides us, and there are many brothers and sisters with us," he stated.
These Christians "live their faith every day and bring to the world the lordship of God's love together with us, in silence and obscurity, in their family life and work, in their problems and difficulties, in their joys and hopes," he said.
Jesus' ascension into heaven does not mean he is absent, Pope Francis asserted.
Instead, it tells us that he is alive among us "in a new way."
"The ascension of Jesus into heaven, then, reveals to us this reality that is so comforting for our journey: [that] in Christ, true God and true man, our humanity was brought to God," he remarked.
Jesus "has opened the passage up for us," the Pope said, comparing Christ to a mountaineer who leads the climb up the rock face, has reached the summit and "draws us up to him, leading us to God."
"If we entrust our lives to him, if we let ourselves be guided by him, we are sure to be in safe hands, in the hands of our Savior, our advocate," the Pope said.
"Jesus is the only and eternal Priest, who passed through death and the tomb and rose again and ascended into heaven," he explained. "He is with God the Father, where he always intercedes in our favor."
Pope Francis noted that Jesus is no longer "in a definite place in the world, as he was before the Ascension.
"He is now in the lordship of God, present in all space and time, next to each of us."
But the Pope underscored that entering "into the glory of God requires daily fidelity to his will, even when it requires sacrifice, when at times it requires us to change our plans."
A prime example of how to be faithful to the Lord can be seen in Jesus' ascension, which happened on the Mount of Olives, near the place where he had retired in prayer before his passion "to be in profound union with the Father."
"Once again," the Pope noted, "we see that prayer gives us the grace to live faithfully to the project of God."
He advised the pilgrims to not be afraid to turn to Jesus with their fears and ask for his blessing and mercy.
"He always forgives us; he is our advocate," Francis said. "He always defends us; [and] we must never forget this."


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One is a performance-enhancing drug, the other is a ... way guys get ready to play over 162 games. ... I think it would be real tough if they threw 25 games or 75 games or a commissioner's decision [at amphetamine users]. ... There are days I can't get going when I have to drink two, three cups of coffee to get jittery. [If amphetamines are banned,] We're probably going to see a lot of lethargic guys out there.Yeah, Johnny ... coffee. MLB is gonna outlaw coffee!
At this point, I agree with Yankees general partner Steve Swindal, who said, back on September 10: "I'll be satisfied if the team makes the playoffs."
One game out with four to play is small potatoes compared to last year's ALCS, so my faith remains firm.
Various one-game tie-breakers:
East: Boston at New YorkTonight's Games (all at 7:00):
Central: Chicago at Celevland
Wild Card: Cleveland at Boston, Boston at Chicago, New York at Cleveland
Clement / Downs
Small / Bedard
Sabathia / Fossum


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We posted the statement given by Steve Jobs regarding Flash and why he hates it. As we expected Adobe did reply to that comment made by Steve Jobs. Adobe is now shifting away from Apple devices for Flash Player and AIR.
Here is the quote posted by Adobe.
This morning Apple posted some thoughts about Flash on their web site. The primary issue at hand is that Apple is choosing to block Adobe's widely used runtimes as well as a variety of technologies from other
Clearly, a lot of people are passionate about both Apple and Adobe and our technologies. We feel confident that were Apple and Adobe to work together as we are with a number of other partners, we could provide a terrific experience with Flash on the iPhone, iPad and iPod touch.
However, as we posted last week, given the legal terms Apple has imposed on developers, we have already decided to shift our focus away from Apple's iPhone and iPad devices for both Flash Player and AIR. We are working to bring Flash Player and AIR to all the other major participants in the mobile ecosystem, including Google, RIM, Palm (soon to be HP), Microsoft, Nokia and others.
We look forward to delivering Flash Player 10.1 for Android smartphones as a public preview at Google I/O in May, and then a general release in June. From that point on, an ever increasing number and variety of powerful, Flash-enabled devices will be arriving which we hope will provide a great landscape of choice.
The Journal's Alan Murray had an exclusive interview with Adobe CEO Shantanu Narayen. Here is the video.
(Quote Source)
(Video Source)


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Philly Concept Logos
You've seen concept logos for the Devils and Predators from this artist and now he's moved on to the Philadelphia Flyers for his latest design.
Here are the secondary logos he came up with.
Even if they aren't entirely feasible as NHL logos, they're still very sharp and nice to look at. It's got the best Liberty Bell logo I've ever seen too. Anyway, what do you guys think?
By the way, I've got some great Los Angeles Kings concept art to post tomorrow. I think you'll enjoy it too.


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To get accounting report data from Xero you need to be logged in into Xero. Then you need to select from the menu Add-ons -> G-Accon for Xero -> Get Accounting Reports -> Customer Invoice.
Select Customer Invoice option from the drop down menu. G-Accon for Xero provides the ability to set up the Date Range for your data manually or you can refresh your data dynamically. Date range is limited for 365 days.
You have the ability to set up the Date Range (To and From) dynamically. The report data will be calculated based on the selected Date Range.
There are required attributes for Customer Invoice report:
- Invoice Status (Draft, Deleted, Voided, and so on)
- Region Options (Eastside, North, and so on)
You have the ability to select all value, some, or at least one:
Xero provides Optional features that might be useful for your business.
Change Pull Settings allows you to perform the following operations:
- Create a new Google Sheet
- Display Report Title
- Create Deep Link to Xero
- Display only account codes
- Keep Original Formatting
- Retrieve headers
- Create a data Table around pulled data
- Freeze Data Table Header
- Exclude Auto Refresh
You can also provide the start cell, for instance, A11. And provide the name of the template in Template Name field, for instance, Template #1.
To schedule the auto Refresh, you can use option Schedule a Refresh. The important to remember this settings will take effect only if the master auto refresh process in turned on. See the Automation process explanation.
To execute the process, click on the "Execute" button. The Customer Invoice details will be populated on the Google Sheet.


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It's free to list private sales on the forum unfortunately as with any forum there are some people who will use the site to basically advertise parts they don't have and steal money sent to them! we do not have any way to regulate this
Helpful tips on how to avoid being ripped offto avoid this happening to you follow these tips!
Check the details ie. address phone number email etc. against the list of banned members we have
*****CLICK HERE FOR LIST OF BANNED MEMBERS DETAILS*****if the details match it means that member has rejoined back up - please report it to me!
Carry out all transactions on the forum - ie. reply to a post on the forum rather than through PM and if you don't receive the goods reply to the post, that way it gives early warning to others if your parts have not arrived!
check previous for sale post the member has made to see if all transactions have been ok.
By all means reply to the post when your item has arrived to let others know the seller is trustworthy
Keep details of all money sent and the address's phone numbers etc.
if you have paid by Paypal remember you only have 45 days to claim your money back!


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This form is reserved for convention organizers and event planners
Yaya's participation in convention programming includes (but is not limited to):
- Hosting panels and workshops on a dozen cosplay-related subjects including costume craftsmanship (multiple levels), cosplay performance, makeup/posing/photography, international cosplay, sociology of cosplay, the evolution of cosplay and many more
- Hosting (MCing) main programming events such as costume contests, Fashion Shows, Idol contests, Opening Ceremonies, Charity Auctions and more.
- Judging contests such as costuming and cosplay
- Appearing in costume during the event
- Signing autographs at her merchandise table or other appropriate setting
- Photo Ops with attendees
If you would like to invite Yaya to make a guest appearance at your convention, please fill out the booking form with as much detail about your event as possible and any offers or proposals. Thank you.
(OZ Comic Con Australian Cosplay Championship photo taken by Jarrah)


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Lillet of the Valley Recipe
Lillet of the Valley is a variation of the Col du Sabion, a drink we first encountered at the Manhattan Cocktail Classic. It features blood orange liqueur and Gran Classico, which we're pretty obsessed with. The lightness of cider combined with the tart and earthy citrus flavors make this drink an excellent companion while watching the sunset from your rooftop.
- Yield:1
- Active time: 5 minutes
- Total time:5 minutes
- 2 ounces chilled Lillet Blanc
- 1 ounce Solerno Blood Orange Liquor
- 3 dashes orange bitters, such as Bitter Truth
- 3 dashes grapefruit bitters
- 1 teaspoon Gran Classico Bitter
- 3 ounces chilled semi-dry cider
- 1 thick twist orange twist
Fill a mixing glass with ice, then add Lillet, Solerno, orange bitters, grapefruit bitters, and Gran Classico. Stir well.
Strain into an ice-filled collins glass. Top off with cider. Stir gently to combine and garnish with orange twist.