text:
7377 11th Avenue, Burnaby Listing #: R2488608
Beautiful side by side Duplexes! Total of 4 BEDS & 3.5 BATHS. Main floor has inviting living room w/gas fireplace. Grand kitchen finished with high end European built-in appliances & oversized Island. Family room has built in entertainment unit w/fireplace & 9 ft ceilings throughout. This home comes with A/C, Radiant heated floors, Modern LED light fixtures, Stucco & stone exterior, fully fenced large private backyard, security system with cameras, central vacuum, engineered wood floors & tiles throughout, insulated garage & potential for 1 BED side suite, ideal for in-law or for a student. Walking distance to Bus. Steps to Langley Farm Market, St. Thomas More, Our Lady of Mercy & High Gate Mall. 10 mins drive to Metrotown. Central location easy access to all major routes.
Taxes (2018): $5,441.74Amenities: Air Cond./Central
- Air Conditioning
- ClthWsh
- Dryr
- Frdg
- Stve
- Disposal - Waste
- Drapes
- Window Coverings
- Garage Door Opener
- Heat Recov. Vent.
- Microwave
- Pantry
- Security System
- Vacuum - Built In
Similar Listings
Listed By: RE/MAX Crest Realty
Disclaimer: The data relating to real estate on this web site comes in part from the MLS Reciprocity program of the Real Estate Board of Greater Vancouver or the Fraser Valley Real Estate Board. Real estate listings held by participating real estate firms are marked with the MLS Reciprocity logo and detailed information about the listing includes the name of the listing agent. This representation is based in whole or part on data generated by the Real Estate Board of Greater Vancouver or the Fraser Valley Real Estate Board which assumes no responsibility for its accuracy. The materials contained on this page may not be reproduced without the express written consent of the Real Estate Board of Greater Vancouver or the Fraser Valley Real Estate Board.


text:
May 24, 1943 - November 10, 2013
Warwick, NY
John S. Hicks, of Warwick, NY, passed away on November 10, 2013 at Schervier Pavilion. He was 70 years old. He was the son of the late Dr. Andrew R. and Barbara (Buttenheim) Hicks and was born on May 24, 1943 in Fayetteville, NC.
He graduated from Warwick Valley High School in 1961, Colgate University in 1965 and Albany Law School in 1975.
John began his law career with the late Albert Davis in Chester, NY, and maintained his own private practice until 2002. He also served as an attorney for Chester, Harriman and Port Jervis, and served as Warwick Town Attorney from 2002 to 2013.
He served on many community boards, including Orange County United Way, Arden Hill Hospital and Leadership Orange, and was a founding board member of Warwick Valley Community Center, then known as Bandwagon.
His volunteer activities also included the Warwick Jaycees and he chaired many projects, served as president and was a JCI senator. He was also selected as the Jaycees Citizen of the Year in 1992.
John was a proud veteran, serving in the U. S. Army from 1966-1969. He was a life member of American Legion Post #214 and also a member of the VFW.
John enrolled in the Republican Party as soon as he was eligible to vote. He served on the Warwick Town Board from 1971 to 1975. He served as first vice-chairman on the Orange County Republican Committee from 1991 to 1995 and was then elected as chairman and served from 1995 to 2003. He was also a delegate to two Republican National Conventions. In 2012, he and three of his colleagues formed a political consulting company, Red Pillar Consulting, and worked on several successful Republican campaigns in the Hudson Valley.
John is survived by his wife, Judith A. Hicks; his daughters: Deanna C. Belcher, her husband, Wayne Belcher and their daughters, Addie and Clara; Stephanie A. Kilkenny and her husband, Patrick Kilkenny; Lisa E. Hicks, her husband, Oscar Mena and their daughters, Catherine and Martha. He is also survived by his stepsons, J. Michael Denning, his wife, Tara Lee and their sons, Andrew, Jack, Christopher and Emmett; J. Mark Denning and Michelle Benoit and his sons, Sierra and Makaia; Jeffrey C. Denning and his wife, Tina Denning. He is further survived by his sister, B. Carroll Possick and her husband, Dr. Stanley G. Possick; his brothers: C. Andrew Hicks and his wife, Mary Anne Hicks; and Gill V. Hicks and his wife, Donna Hicks. John also leaves several cherished nieces and nephews; his Augustine in-laws, who welcomed him into their family; and many valued friends.
He was predeceased by his nephew, Adam Hicks and his sister-in-law, Margaret G. Augustine.
Donations in John's memory may be made to Warwick Valley Community Center, 22 Hamilton Avenue, Warwick, NY 10990 or The Heritage Foundation, 214 Massachusetts Avenue NE, Washington, DC 20002.
A memorial service to celebrate John's life will be held at a later date.
Arrangements are under the direction of Lazear-Smith & Vander Plaat Memorial Home, 17 Oakland Avenue, Warwick, NY 10990. For further information or to send an online condolence, see www.lsvpmemorialhome.com

subset: commoncrawl


text:
SAUGERTIES — Native Indians will again tread the paths and waterways of the Hudson Valley this week.
SAUGERTIES — Native Indians will again tread the paths and waterways of the Hudson Valley this week.
Two different American Indian groups will traverse the region, one traveling by horseback from Albany to New York City and beyond, the other by canoe on the Hudson River, also to the city.
One is The Dakota Unity Ride of Manitoba with its horses; the other, the Two Row Wampum group, traveling by canoe. They represent the Onondaga Nation and its neighbors, who mostly lived in central New York. They're carrying a replica of the historic Two Row Wampum belt to the state capital for a two-week stay before continuing on to the United Nations later this month.
The Iroquois recorded a treaty 400 years ago with the belt of shell beads in parallel strips, representing the Dutch ships and their canoes traveling the same path.
Here is the local schedule of the two groups:
MONDAY: The riders are set to cross the Rosendale Trestle at 10 a.m., then head off to Woodstock. There, they will travel from the Woodstock Community Center to the KTD Buddhist Retreat Center on Overlook Mountain for a ceremony at the Magic Meadow from 2 p.m. to 4 p.m.
TUESDAY: At 11 a.m., the riders travel from Mount Tremper on Route 212 through Phoenicia to the Menla Mountain Retreat for an afternoon of ceremonies.
THURSDAY: The paths of the two groups will converge in Kingston for ceremonies centered at the Hudson River Maritime Museum on the Strand, Kingston's waterfront. The event runs from 11 a.m. to 2:30 p.m.
FRIDAY: The Dakota riders climb Mount Beacon to the fire tower for a ceremony from 9:30 a.m. to 1:30 p.m.
SATURDAY: The Dakota Unity Ride converges with Two Row Wampum again on Saturday at the Walkway over the Hudson in Highland. The Unity group will cross the walkway on horseback as the Canoe contingent crosses beneath them on the river. That event kicks off at 9:30 a.m., organizers say.
SUNDAY: Beginning at 11 a.m. from the intersection of Routes 375 and 212, the riders lead a flag procession in Woodstock on the International Day For peace. A concert follows later that afternoon at the Colony Cafe on Rock City Road.
The Two Row canoeists continue to hold events at communities along the river prior to arrival in New York City on Aug. 9.
The Unity riders will continue throughout the summer on their journey to Washington, D.C.


text:
Host the best kids Valentine party ever. Here are some fun ideas to keep the kids entertained and enjoying the holiday.
Follow the fun
Find what you're looking for?
Inspiration for your next fun idea…
Check out what's popular
AboutHi! My name is Jenn Fossum and I'm all about the FUN! I'm always seeking for new projects to complete, new adventures to enjoy and new traditions to pursue with my family. I hope you enjoy and find something FUN to do.


text:
Want to see your favorite candidates on the ballot in Oklahoma?
This year the Green Party and the Libertarian Parties are working together to get both on the Oklahoma ballot. We will both be gathering petition signatures and the total good signatures needed is 24,745 before March 1, 2016. We need to get more than the required number since some are always disqualified. That is not a lot of time but this year the number needed is far less than the 41,242 required in the past and both parties are working together so we have high hopes.
What you will need to participate: Petition Form (print the form that opens)
To get started: Instructions
Contact us before beginning:


text:
Pubmed du 05/07/19
1. Alzghoul L, Abdelhamid SS, Yanis AH, Qwaider YZ, Aldahabi M, Albdour SA. The association between levels of inflammatory markers in autistic children compared to their unaffected siblings and unrelated healthy controls. Turkish journal of medical sciences. 2019 ; 49(4).
Background/aim : Autism spectrum disorder (ASD) describes a range of neurodevelopmental disabilities that impair behavior and communication. Although it is relatively prevalent, the pathophysiology is still subject to speculation and debate. The aim of this study is to identify a possible association between interleukin-6, -8, -9, and -10 and tumor necrosis factor alpha (TNF-alpha) in autism among Jordanian children by comparing the plasma levels of these cytokines in autistic children with those of their unaffected siblings and unrelated healthy controls. Materials and methods : In this study, 80 Jordanian children under the age of 12 with diagnosed autism were selected. For comparison, 51 unaffected siblings and 86 unrelated healthy controls were also recruited. Venous blood was collected and interleukin levels in all three groups were investigated. Results : Interleukin-6 was found to be significantly higher in the plasma of both autistic children and their siblings compared with the unrelated healthy control group (P < 0.05). As for interleukin-8 and TNF-alpha, plasma levels were significantly higher exclusively in autistic children compared to their siblings and unaffected control subjects (P < 0.001, P < 0.001). There was no significant difference between plasma levels of the previously mentioned cytokines in the siblings and the unrelated control group. As for interleukin-9 and interleukin-10, no significant differences were found between all three groups (P = 0.15, P = 0.35). Conclusion : We found that interleukin-8 and TNF-alpha were exclusively elevated in autistic Jordanian children, while interleukin-6 was elevated in both autistic children and their siblings, potentially dismissing its significance. These results may lead to a better understanding of the disorder's pathophysiology, early testing, and diagnosis.
Lien vers le texte intégral (Open Access ou abonnement)
2. Bethin KE, Kanapka LG, Laffel LM, Majidi S, Chaytor NS, MacLeish S, Adams R, Foster NC. Autism spectrum disorder in children with Type 1 diabetes. Diabetic medicine : a journal of the British Diabetic Association. 2019.
AIM : Links between autism spectrum disorder (ASD) and autoimmune diseases, including Type 1 diabetes have been proposed. This study assessed the frequency of ASD in children with Type 1 diabetes in the T1D Exchange (T1DX) registry and the impact of ASD on characteristics of children with Type 1 diabetes. METHODS : Analysis included 10 032 participants aged < 18 years (median Type 1 diabetes duration 6.5 years, 48% female, 77% non-Hispanic White). Diagnosis of ASD was defined as autism, Asperger's or pervasive developmental disorder. RESULTS : A diagnosis of ASD was recorded for 159 (1.58%) participants. Those with ASD were predominantly male (88% vs. 51% of those without ASD, P < 0.001) and slightly older (median 14 vs. 13 years, P = 0.022). Occurrence of diabetic ketoacidosis at Type 1 diabetes diagnosis was similar (35% vs. 41%, P = 0.161). Pump use was lower in those with ASD (51% vs. 63%, P = 0.005) but continuous glucose monitor use was similar (24% vs. 27%, P = 0.351). Median HbA1c was slightly lower in those with ASD [68 vs. 69 mmol/mol (8.4% vs. 8.5%), P = 0.006]. This difference was more pronounced after adjusting for confounders. CONCLUSIONS : The frequency of ASD in the T1DX registry was similar to that in the general population. These data show that despite deficits in communication, occurrence of diabetic ketoacidosis was similar in youth with and without ASD. Pump use was less frequent in those with ASD, possibly due to sensory issues, although CGM use did not differ. The lower HbA1c may be due to a more regimented routine with ASD. Because comorbidities such as ASD complicate care of patients with Type 1 diabetes, further research is needed to support these children. This article is protected by copyright. All rights reserved.
Lien vers le texte intégral (Open Access ou abonnement)
3. Black MH, Mahdi S, Milbourn B, Thompson C, D'Angelo A, Strom E, Falkmer M, Falkmer T, Lerner M, Halladay A, Gerber A, Esposito C, Girdler S, Bolte S. Perspectives of key stakeholders on employment of autistic adults across the united states, australia, and sweden. Autism Res. 2019.
Despite efforts to improve employment outcomes for autistic individuals, internationally their employment rates remain low. There is a need to better understand the factors influencing successful employment for autistic adults in the labor market from the perspectives of multiple key stakeholders. This study represents the second in a series of papers conducted as part of an International Society for Autism Research policy brief aimed at improving employment outcomes for autistic individuals. A community consultation methodology using focus groups, forums, and interviews was applied with autistic individuals (n = 19), family members (n = 18), service providers (n = 21), employers (n = 11), researchers (n = 5), and advocacy group representatives (n = 5) in Australia, Sweden, and the United States, aiming to identify the factors perceived to determine gaining and maintaining employment for autistic individuals. Directed content analysis, guided by the International Classification of Functioning, Disability and Health (ICF), was conducted to investigate the key factors influencing employment outcomes for autistic individuals. Meaningful verbal concepts, or units of text with common themes, were also derived from the qualitative data and then linked and compared to the ICF Autism Spectrum Disorder (ASD) Core-sets. Across countries, activity and participation and environmental factor categories of the ICF were the most associated with employment outcomes. Results suggest that removal of environmental barriers and enhancing environmental facilitators may assist to remediate ASD-related difficulties in the workplace. Autism Res 2019, (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY : This study sought to understand the perspectives of autistic individuals and key stakeholders on factors influencing if autistic adults get and keep jobs. Across Australia, Sweden, and the United States, focus groups and interviews were conducted to understand international perspectives on what helps and hinders getting and keeping a job for autistic individuals. The environment, including supports, relationships, attitudes, and services, were perceived to be the most important for workplace success. Intervention targeting barriers and facilitators in the workplace environment may support autistic adults to be successful in the labor market.
Lien vers le texte intégral (Open Access ou abonnement)
4. Bremer E, Cairney J. Reliable and Feasible Fitness Testing for Children on the Autism Spectrum. Research quarterly for exercise and sport. 2019 : 1-10.
Purpose : This study examined the test-retest reliability and feasibility of select fitness assessments in 7-12 year old children on the autism spectrum. Method : Participants (N = 14 ; n = 1 female ; Mage = 9.5 +/- 1.7 years) completed 7 fitness assessments, administered in a random order, on two occasions : Bruce protocol ; Modified 6-minute walk test (M6MWT) ; Wingate anaerobic cycling test ; muscle power sprint test (MPST) ; sit & reach ; standing long jump ; and grip strength. Intraclass correlations (two-way mixed with absolute agreement) were computed to examine test-retest reliability. Feasibility was assessed by questionnaire following the first administration of each test. Results : The Wingate (ICC = .956), standing long jump (ICC = .925), grip strength (ICC = .913), and sit and reach (ICC = .829) tests demonstrated good- to- excellent reliability, while the Bruce protocol (ICC = .811), M6MWT (ICC = .510), and MPST (ICC = .703) demonstrated moderate- to- good reliability based on the 95% confidence intervals of the ICC. All tests demonstrated assessor-rated feasibility scores of 70/100 or higher and child-rated feasibility scores of 66/100 or higher. Conclusion : The results demonstrate moderate- to excellent test-retest reliability for select fitness tests. Short, single-instruction (e.g., standing long jump) tests may be more reliable than lengthier assessments (e.g., M6MWT) in this population. Implications of this work include the ability of practitioners and researchers to feasibly and reliably measure the fitness of school-aged children on the autism spectrum for ongoing health and behavioural monitoring and intervention purposes.
Lien vers le texte intégral (Open Access ou abonnement)
5. Griffin MM, Fisher MH, Lane LA, Morin L. Responses to bullying among individuals with intellectual and developmental disabilities : Support needs and self-determination. J Appl Res Intellect Disabil. 2019.
BACKGROUND : Compared to the general population, individuals with intellectual and developmental disabilities (IDD) more often experience bullying and its negative social and emotional impacts. Prior studies explored bullying of individuals with IDD primarily through investigations of the perspectives of others and the negative impacts of bullying. The current study examined how individuals with IDD describe their responses to experiences of bullying, with a focus on whether responses included component skills of self-determination. METHOD : Eighteen adults with IDD (50% female) aged 18-63 years were interviewed about their experiences with bullying. Interviews were analysed to determine responses to bullying and the degree to which their responses demonstrated self-determination. RESULTS : Data analysis revealed two primary themes, outside support and self-determination, with additional subthemes. CONCLUSIONS : Findings provide a more nuanced description of the ways in which individuals with IDD respond to bullying, including the demonstration of self-determination skills. Implications for research and practice are discussed.
Lien vers le texte intégral (Open Access ou abonnement)
6. Griffiths S, Allison C, Kenny R, Holt R, Smith P, Baron-Cohen S. The Vulnerability Experiences Quotient (VEQ) : A Study of Vulnerability, Mental Health and Life Satisfaction in Autistic Adults. Autism Res. 2019.
Co-morbid mental health conditions such as anxiety and depression are extremely common in autistic adults. Vulnerability to negative life experiences such as victimisation and unemployment may be partially responsible for the development of these conditions. Here we measure the frequency of negative life experiences in autistic adults and explore how these are associated with current anxiety and depression symptoms and life satisfaction. We developed the Vulnerability Experiences Quotient (VEQ) through stakeholder consultation. The VEQ includes 60 items across 10 domains. Autistic adults with a clinical diagnosis and non-autistic controls completed the VEQ, screening measures for anxiety and depression, and a life-satisfaction scale in an online survey. Likelihood of experiencing each VEQ event was compared between groups, using binary logistic regression. Mediation analysis was used to test whether total VEQ score mediated the relationship between autism and (1) depression (2) anxiety and (3) life satisfaction. Autistic adults (N = 426) reported higher rates of the majority of events in the VEQ than non-autistic adults (N = 268). They also reported more anxiety and depression symptoms and lower life satisfaction. Group differences in anxiety, depression and life satisfaction were partially mediated by VEQ total score. This study highlights several important understudied areas of vulnerability for autistic adults, including domestic abuse, contact with social services (as parents) and financial exploitation and hardship. Improved support, advice and advocacy services are needed to reduce the vulnerability of autistic adults to negative life experiences, which may in turn improve mental health and life satisfaction in this population. Autism Res2019. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY : This study investigated whether autistic adults are more vulnerable to certain negative life experiences, and whether these experiences are related to anxiety, depression and life satisfaction. We found that autistic adults are more vulnerable to many different negative life events, including employment difficulties, financial hardship and domestic abuse. Negative life experiences partially explained the higher rates of anxiety and depression symptoms and lower life satisfaction in autistic adults compared to non-autistic adults. Improved support services are required to reduce the vulnerability of autistic adults. Reducing vulnerability may improve mental health and increase life satisfaction in this population.
Lien vers le texte intégral (Open Access ou abonnement)
7. Gubbiotti M, Balboni G, Bini V, Elisei S, Bedetti C, Marchiafava M, Giannantoni A. Bladder and bowel dysfunction, adaptive behaviour and psychiatric profiles in adults affected by autism spectrum disorders. Neurourology and urodynamics. 2019.
AIMS : Bladder and bowel dysfunction (BBD) have been recognized in children affected by autism spectrum disorder (ASD), but no consistent information exist in adults with the condition. We evaluated the prevalence of BBD and the impact of psychiatric and behavioural profiles in adults affected by ASD. METHODS : Twenty-two adults and 13 children/teens with ASD and a matched group of typically developing subjects (TD) were prospectively studied. Patients and TD subjects underwent the evaluation of urinary incontinence (UI : diurnal, continuous or intermittent), nocturnal enuresis (NE), and bowel disturbances with the 3-day voiding and bowel diary. In addition, assessment of intellectual disability (ID) and psychiatric and adaptive behaviours with the Neuropsychiatric Inventory Scale (NPI) and the Vineland Adaptive Behaviour Scale 2nd Edition (Vineland-II), was performed. RESULTS : In adults, any type of incontinence was observed in 81.8% of cases, and NE and intermittent UI in 59.0% and 36.3% of patients, respectively. Faecal incontinence and constipation were detected 36.3% and in 68.1% of cases, respectively. ID was severe in 2 cases and profound in 18 ; NPI and Vineland-II items most affected were "Irritability/Lability," "Motor Activity," and "Agitation," and IQ-Socialization and IQ-Communication. Significant relationships were identified between intermittent UI and greater ID (P < .02) and high "anxiety" (P < .05), and between NE and high "euphoria/elevated mood" (P < .05). These results were similar to those observed in children/teens. CONCLUSIONS : Adults with ASD, and greater ID and mood disorders, present with a high prevalence of BBD. A shared pathogenetic mechanism could underlie the co-occurrence of ASD, mood disorders, and BBD.
Lien vers le texte intégral (Open Access ou abonnement)
8. Lee CE, Burke M, Arnold CK, Owen A. Correlates of current caregiving among siblings of adults with intellectual and developmental disabilities. J Appl Res Intellect Disabil. 2019.
BACKGROUND : As individuals with intellectual and developmental disabilities (IDD) grow older, siblings are likely to become caregivers for their brothers and sisters with IDD. Thus, it is important to identify the correlates of sibling caregiving to facilitate transitions to caregiving roles. METHOD : This study involved the secondary analysis of a national data set of 429 adult siblings of individuals with IDD. RESULTS : Current sibling caregiving was positively correlated with sibling relationship quality, sibling advocacy and future planning, maladaptive behaviours of individuals with IDD, and family size. Current sibling caregiving was negatively correlated with parent caregiving abilities and functional abilities of individuals with IDD. Further, among siblings who provided care, the level and nature of sibling caregiving were negatively correlated with parent caregiving abilities. CONCLUSIONS : The results identify the correlates of current caregiving among siblings of individuals with IDD. More research is needed to understand current sibling caregiving.
Lien vers le texte intégral (Open Access ou abonnement)
9. Li X, Han X, Tu X, Zhu D, Feng Y, Jiang T, Yang Y, Qu J, Chen JG. An Autism-Related, Nonsense Foxp1 Mutant Induces Autophagy and Delays Radial Migration of the Cortical Neurons. Cereb Cortex. 2019 ; 29(7) : 3193-208.
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that has a strong genetic component. Disruptions of FOXP1, a transcription factor expressed in the developing cerebral cortex, were associated with ASD. FOXP1(R525X) is a de novo heterozygous mutation found in patients with autism and severe mental retardation. To explore the neuronal basis of FOXP1(R525X) in ASD, we created Foxp1(R521X), a mouse homolog of the human variant. Ectopic expression of Foxp1(R521X) led to cytoplasmic aggregates and activated macroautophagy in neuroblastoma N2a cells and the developing neuronal cells. Cortical neurons expressing Foxp1(R521X) exhibited delayed migration and altered dendritic morphology. As a control, mutant Y435X that was expressed diffusively in the cytoplasm did not induce autophagy and migration delay in the cortex. The embryonic cortical cells had a minimal activity of nonsense-mediated mRNA decay (NMD) as assayed by a splicing-dependent NMD reporter. We hypothesize that the developing neuronal cells use autophagy but not NMD as a safeguard mechanism against nonsense mutant aggregates, resulting in impairment of the cortical development. This study suggests a novel mechanism other than heterozygous loss of FOXP1 for the development of ASD and may advance our understanding of the complex relationships between gene mutation and the related psychiatric disorders.
Lien vers le texte intégral (Open Access ou abonnement)
10. Morgan M, Hills PJ. Correlations between holistic processing, Autism quotient, extraversion, and experience and the own-gender bias in face recognition. PLoS One. 2019 ; 14(7) : e0209530.
The variability in the own-gender bias (OGB) in face-recognition is thought to be based on experience and the engagement of expert face processing mechanisms for own-gender faces. Experience is also associated with personality characteristics such as extraversion and Autism, yet the effects of these variables on the own-gender bias has not been explored. We ran a face recognition study exploring the relationships between own-gender experience, holistic processing (measured using the face-inversion effect, composite face effect, and the parts-and-wholes test), personality characteristics (extraversion and Autism Quotient) and the OGB. Findings did not support a mediational account where experience increases holistic processing and this increases the OGB. Rather, there was a direct relationship between extraversion and Autism Quotient and the OGB. We interpret this as personality characteristics having an effect on the motivation to process own-gender faces more deeply than opposite-gender faces.
Lien vers le texte intégral (Open Access ou abonnement)
11. Provenzani U, Fusar-Poli L, Brondino N, Damiani S, Vercesi M, Meyer N, Rocchetti M, Politi P. What are we targeting when we treat autism spectrum disorder ? A systematic review of 406 clinical trials. Autism. 2019 : 1362361319854641.
The number of trials aimed at evaluating treatments for autism spectrum disorder has been increasing progressively. However, it is not clear which outcome measures should be used to assess their efficacy, especially for treatments which target core symptoms. The present review aimed to provide a comprehensive overview regarding the outcome measures used in clinical trials for people with autism spectrum disorder. We systematically searched the Web of Knowledge(SM) database between 1980 and 2016 to identify published controlled trials investigating the efficacy of interventions in autism spectrum disorder. We included 406 trials in the final database, from which a total of 327 outcome measures were identified. Only seven scales were used in more than 5% of the studies, among which only three measured core symptoms (Autism Diagnostic Observation Schedule, Childhood Autism Rating Scale, and Social Responsiveness Scale). Of note, 69% of the tools were used in the literature only once. Our systematic review has shown that the evaluation of efficacy in intervention trials for autism spectrum disorder relies on heterogeneous and often non-specific tools for this condition. The fragmentation of tools may significantly hamper the comparisons between studies and thus the discovery of effective treatments for autism spectrum disorder. Greater consensus regarding the choice of these measures should be reached.
Lien vers le texte intégral (Open Access ou abonnement)
12. Reindal L, Naerland T, Weidle B, Lydersen S, Andreassen OA, Sund AM. Age of First Walking and Associations with Symptom Severity in Children with Suspected or Diagnosed Autism Spectrum Disorder. J Autism Dev Disord. 2019.
Age of first walking (AOW) is reported to be later in autism spectrum disorder (ASD) compared with typical development. However, the relationship between AOW and variations in ASD symptoms across different neurodevelopmental disorders is largely unknown. This study investigated AOW and its association with autism symptom severity in a large sample of children (N = 490, 23% females) clinically evaluated for suspected ASD, differentiated into ASD (n = 376) and non-ASD (n = 114) diagnoses. Children with ASD achieved independent walking significantly later than children with non-ASD diagnoses. AOW was significantly associated with ASD symptom severity, and females had a non-significant later AOW. The current findings suggest that in cases with delayed AOW, ASD should be considered as an actual differential diagnosis, perhaps particularly in girls.
Lien vers le texte intégral (Open Access ou abonnement)
13. Sampaio GLA, Martins GLS, Paredes BD, Nonaka CKV, da Silva KN, Rossi EA, Dos Santos RR, Soares MBP, Souza BSF. Generation of an induced pluripotent stem cell line from a patient with autism spectrum disorder and SCN2A haploinsufficiency. Stem cell research. 2019 ; 39 : 101488.
Autism spectrum disorders (ASDs) are a group of diseases that affect social interaction, communication and behavior. Molecular mechanisms involved in the pathogenesis of ASDs are complex due to genetic heterogeneity. Recently, pathogenic variants of SCN2A have been strongly associated with ASDs. Here, we generated iPSCs from a patient with ASD and a heterozygous nonsense mutation in SCN2A, by reprogramming mesenchymal stromal cells with non-integrating vectors. The generated iPSC line expresses pluripotency markers, presents a normal karyotype and is able to differentiate into the three germ layers. This iPSC line is a useful tool for modeling ASD and drug screening studies.
Lien vers le texte intégral (Open Access ou abonnement)
14. Toledo MA, Wen TH, Binder DK, Ethell IM, Razak KA. Reversal of ultrasonic vocalization deficits in a mouse model of Fragile X Syndrome with minocycline treatment or genetic reduction of MMP-9. Behav Brain Res. 2019 : 112068.
Fragile X Syndrome (FXS) is a leading genetic cause of autism and intellectual disabilities. The Fmr1 knockout (KO) mouse is a commonly studied pre-clinical model of FXS. Adult male Fmr1 KO mice produce fewer ultrasonic vocalizations (USVs) during mating, suggestive of abnormal social communication. Minocycline treatment for 2 months from birth alleviates a number of FXS phenotypes in mice, including USV call rate deficits. In the current study, we investigated if treatment initiated past the early developmental period would be effective, given that in many cases, individuals with FXS are treated during later developmental periods. Wildtype (WT) and Fmr1 KO mice were treated with minocycline between postnatal day (P) 30 and P58. Mating-related USVs were then recorded from these mice between P75 and P90 and analyzed for call rate, duration, bandwidth, and peak frequency. Untreated Fmr1 KO mice call at a significantly reduced rate compared to untreated WT mice. After minocycline treatment from 1-2 months of age, WT and Fmr1 KO mice exhibited similar call rates, due to an increase in calling in the latter group. Minocycline is thought to be effective in reducing FXS symptoms by lowering matrix-metalloproteinase-9 (MMP-9) levels. To determine whether abnormal MMP-9 levels underlie USV deficits, we characterized USVs in Fmr1 KO mice which were heterozygous for MMP-9 (MMP-9(+/-)/Fmr1 KO). The MMP-9(+/-)/Fmr1 KO mice were between P75 and P90 at the time of recording. MMP-9(+/-)/Fmr1 KO mice exhibited significantly increased USV call rates, at times even exceeding WT rates. Taken together, these results suggest that minocycline may reverse USV call rate deficits in Fmr1 KO mice through attenuation of MMP-9 levels. These data suggest targeting MMP-9, even in late development, may reduce FXS symptoms.
Lien vers le texte intégral (Open Access ou abonnement)
15. Tovar AE, Rodriguez-Granados A, Arias-Trejo N. Atypical Shape Bias and Categorization in Autism : Evidence from Children and Computational Simulations. Dev Sci. 2019 : e12885.
The shape bias, a preference for mapping new word labels onto the shape rather than the color or texture of referents, has been postulated as a word learning mechanism. Previous research has shown deficits in the shape bias in children with autism even though they acquire sizeable lexicons. While previous explanations have suggested the atypical use of color for label extension in individuals with autism, we hypothesize an atypical mapping of novel labels to novel objects, regardless of the physical properties of the objects. In Experiment 1, we demonstrate this phenomenon in some individuals with autism, but the novelty of objects only partially explains their lack of shape bias. In a second experiment, we present a computational model that provides a developmental account of the shape bias in typically developing children and in those with autism. This model is based on theories of neurological dysfunctions in autism, and it integrates theoretical and empirical findings in the literature of categorization, word learning, and the shape bias. The model replicates the pattern of results of our first experiment and shows how individuals with autism are more likely to categorize experimental objects together on the basis of their novelty. It also provides insights into possible mechanisms by which children with autism learn new words, and why their word referents may be idiosyncratic. Our model highlights a developmental approach to autism that emphasizes deficient representations of categories underlying an impaired shape bias. This article is protected by copyright. All rights reserved.
Lien vers le texte intégral (Open Access ou abonnement)
16. Yassin W, Kojima M, Owada K, Kuwabara H, Gonoi W, Aoki Y, Takao H, Natsubori T, Iwashiro N, Kasai K, Kano Y, Abe O, Yamasue H. Paternal age contribution to brain white matter aberrations in autism spectrum disorder. Psychiatry and clinical neurosciences. 2019.
AIM : Although advanced parental age holds an increased risk for autism spectrum disorder (ASD), its role as a potential risk factor for an atypical white matter development underlying the pathophysiology of ASD has not yet been investigated. The current study was aimed to detect white matter disparities in ASD, and further investigate the relationship of paternal and maternal age at birth with such disparities. METHODS : Thirty-nine adult males with high-functioning ASD and 37 typically developing (TD) males were analyzed in the study. FMRIB Software Library and Tract-Based Spatial Statistics were utilized to process and analyze the diffusion tensor imaging data. RESULTS : Subjects with ASD exhibited significantly higher mean diffusivity (MD) and radial diffusivity (RD) in white matter fibers including the association (inferior fronto-occipital fasciculus, right inferior longitudinal fasciculi, superior longitudinal fasciculi, uncinate fasciculus, and cingulum), commissural (forceps minor), and projection tracts (anterior thalamic radiation, and right corticospinal tract) compared to TD subjects (Padjusted < .05). No differences were seen in either fractional anisotropy or axial diffusivity. Linear regression analyses assessing the relationship between parental ages and the white matter aberrations revealed a positive correlation between paternal age (PA), not maternal age (MA), and both MD and RD in the affected fibers (Padjusted < .05). Multiple regression performed, showed that only PA was a predictor of both MD and RD." CONCLUSION : Our findings suggest that PA contributes to the white matter disparities seen in individuals with ASD compared to TD. This article is protected by copyright. All rights reserved.
Lien vers le texte intégral (Open Access ou abonnement)
17. Zheng W, Hu Y, Chen D, Li Y, Wang S. [Improvement of a mouse model of valproic acid-induced autism]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2019 ; 39(6) : 718-23.
OBJECTIVE : To establish an improved mouse model of valproic acid (VPA)-induced autism that better mimics human autism. METHODS : We established mouse models of autism in female C57 mice by intraperitoneal injection of sodium valproate either at a single dose (600 mg/kg) on day 12.5 after conception (conventional group) or in two doses of 300 mg/kg each on days 10 and 12 after conception (modified group), and the control mice were injected with saline only on day 12.5. The responses of the mice to VPA injection, the uterus, mortality rate, and abortion rate were compared among the 3 groups. The morphology and development of the offspring mice were assessed, and their behavioral ontogeny was evaluated using 3- chambered social test, social test, juvenil play test, and open field test. RESULTS : The mortality and abortion rates were significantly lower in the modified model group than in the conventional group (P < 0.01). Compared with those in the control group, the offspring mice in both the conventional group and the modified group showed developmental disorders (P < 0.05). The mortality rate of the newborn mice was significantly lower in the modified group than in the conventional group with a rate of curvy tail of up to 100% (P < 0.001). The offspring mice in both the modified group and conventional group exhibited autism-like behavioral abnormalities, including social disorder and repetitive stereotyped behavior (P < 0.05). CONCLUSIONS : The mouse model of autism established using the modified method better mimics human autism with reduced mortality and abortion rates of the pregnant mice and also decreased mortality rate of the newborn mice.


text:
"...the 148,000-member American Psychological Association is stepping up effortsWell, let's not forget USAToday -- if you open the link, this story was completely SURROUNDED by Green propaganda that I cut because it was so nauseating. I must care for my readers' mental health. More than the APA does.
to foster a broader sense of eco-sensitivity that the group believes will
translate into more public action to protect the planet."
"American Psychological Association leaders say they want to launch a nationalSounds like a Hollywood conspiracy flick ...a secret project to control the minds of an entire country... Ever see "Conspiracy Theory"? But on a bigger scale, with more nefarious objectives. More like "Invasion of the Body Snatchers meets the Stepford Wives". Or "Star Trek Next Generation -- Stalag 17 meets the Gulag Archipelago": Jean Luc Picard Takes on the Borg Collective who have overrun the headquarters of the American Psychological Association.
initiative specifically targeting behavior changes, including developing media
messages that will help people reduce their carbon footprint and pay more
attention to ways they can conserve. They want to work with other organizations
and enlist congressional support to help fund the effort."
Seriously, how bad does it have to get that a quasi-medical organization believes it has right to "change the behavior" of the entire country to promote a political/religious agenda?
"Social psychologist Jessica Nolan studied the issue at the University ofRead between the lines: what this really means is that psychologists have to change our "behavior" so that we *do* disapprove of the "non-sustainable" behavior others.
Arkansas-Fayetteville ...[and] found that students are not particularly inclined
to disapprove of the non-sustainable behavior of others."
"News stories that provided a balanced view of climate change reduced people's... the sentence preceding had the reporter lead into this by saying "negative feedback for those more invested in the environment promotes more sustainable behavior" -- but that is *not* what it means -- what Stanford social psychologist Jon Krosnick means is, *stop criticism of climate change in news stories*.
beliefs that humans are at fault and also reduced the number of people who
thought climate change would be bad, according to research by Stanford social
psychologist Jon Krosnick. "
"Paul Stern, a researcher at the National Academy of Sciences in Washington,Again, the point is, people have to be brainwashed by the APA so they know what the right thing is.
D.C., says people generally want to do the right thing but don't know what it
is. "
"We are recognizing that environmental problems have a tremendous impact on manyYou've got to concretize the meaning of all this -- if it isn't going to be just another fashionable trend, then they've got to force people to support it. They've got to brainwash people with Green propaganda in newsprint and elsewhere (aided and abetted by "news" orgs such as USAToday). They've got to institutionalize it -- in schools, above all, even more than it is now, in more government programs that "protect" the environment, in laws that will *make* you protect the environment -- like San Francisco's forced recycling program, where you face a $1000 fine if you don't "participate".
aspects of our lives, but we need a lot more work," he says. "We can't afford to
let this increased environmental concern become just another fashionable trend."
Give these goons time -- it will spread to the use of lightbulbs, the type and amount of gasoline you buy, the type of car you drive, the appearance of your yard (are you using eco-friendly vegetation?), monitering devices (like the cameras in Britain to moniter your re-cycling habits), to almost anything you can imagine -- fines, felony convictions, "Green Police" (like they have in Boulder, Colorado), busted-in doors, and other qualities of a fully eco-friendly nation.
I mean it. It's limited only by the imagination of these people. I'm reminded once again of a quote from "The Fountainhead" that I used in a recent LTE. It occurs to me often, because it captures the soul of the Left so well (not that the Right isn't occasionally guilty of this, but not as consistently -- for the Left, it's a raison d'etre).
As I said in the LTE, the quote comes when arch-Leftist/Marxist and cynically erudite newspaper columnist Ellsworth Toohey confesses to Peter Keating, the man who sold his soul, his motives for destroying the independent man represented by architect Howard Roark:
"I don't want to kill him. I want him in jail. You understand? In jail. In aThe day the APA gets its way, I suspect they will discover another consequence or two of Ayn Rand's adage that "you can't force a mind" --
cell. Behind bars. Locked, stopped, strapped--and alive. He'll get up when they
tell him to. He'll eat what they give him. He'll move when he's told to move and
stop when he's told. He'll walk to the jute mill, when he's told, and he'll work
as he's told. They'll push him, if he doesn't move fast enough, and they'll slap
his face when they feel like it, and they'll beat him with rubber hose if he
doesn't obey. And he'll obey. He'll take orders. He'll take orders!""
Psychologists determine what it means to think 'green'
By Sharon Jayson, USA TODAY
Those who make human behavior their business aim to make living "green" your business.
Armed with new research into what makes some people environmentally conscious and others less so, the 148,000-member American Psychological Association is stepping up efforts to foster a broader sense of eco-sensitivity that the group believes will translate into more public action to protect the planet.
"We know how to change behavior and attitudes. That is what we do," says Yale University psychologist Alan Kazdin, association president. "We know what messages will work and what will not."
During a four-day meeting that begins today in Boston, an expected 16,000 attendees will hear presentations, including studies that explore how people experience the environment, their attitudes about climate change and what social barriers prevent conservation of resources.
Among the yet-unpublished findings:
• Walking outside rather than inside — even for just 15 minutes — makes you feel happier, more energetic and more protective of the environment, found two studies involving 220 students conducted by psychologists at Carleton University in Ottawa. Researcher Elizabeth Nisbet suggests the findings have broader implications for well-being and mental health.
"People know outside is going to feel much better for them but underpredict how happy they're going to feel after being outside in nature even 15 minutes," she says. "The people inside overestimate their happiness about being inside. It's this error in judgment people have about how happy they are in a different environment that may explain why people don't spend more time in nature."
Behind the research
• Negative feedback can backfire. In two studies, psychologist Amara Brook of California's Santa Clara University and colleague Jennifer Crocker of the University of Michigan asked 212 undergraduates about their ecological footprint. For those not heavily invested in the environment, negative feedback about their ecological footprint actually undermines their environmental behavior, they found.
"Rather than changing their ways to protect the environment, the results of this study suggest that these (people) may give up on their efforts to protect the environment," they report.
But negative feedback for those more invested in the environment promotes more sustainable behavior, they found.
• News stories that provided a balanced view of climate change reduced people's beliefs that humans are at fault and also reduced the number of people who thought climate change would be bad, according to research by Stanford social psychologist Jon Krosnick.
His presentation will detail a decade of American attitudes about climate change. His new experiment, conducted in May, illustrates what he says is a public misperception about global warming. He says there is scientific consensus among experts that climate change is occurring, but the nationwide online poll of 2,600 adults asked whether they believe scientists agree or disagree about it.
By editing CNN and PBS news stories so that some saw a skeptic included in the report, others saw a story in which the skeptic was edited out and another group saw no video, Krosnick found that adding 45 seconds of a skeptic to one news story caused 11% of Americans to shift their opinions about the scientific consensus. Rather than 58% believing a perceived scientific agreement, inclusion of the skeptic caused the perceived amount of agreement to drop to 47%.
American Psychological Association leaders say they want to launch a national initiative specifically targeting behavior changes, including developing media messages that will help people reduce their carbon footprint and pay more attention to ways they can conserve. They want to work with other organizations and enlist congressional support to help fund the effort.
A USA TODAY/Gallup Poll last year found that people know they could do more. Of 1,007 adults surveyed, only about half thought they personally did a good job of protecting the environment; less than 10% said their efforts were "excellent."
Messages that tell people to "be green" or encourage them to follow a more ecologically aware way of living aren't necessarily having the desired effect, psychologists say. Although people know the buzzwords — "sustainability," "carbon footprint" and "global warming" — they aren't really sure what they mean or what they personally can do.
Confusion abounds
"I think most people recognize we face a severe environmental crisis, but it's hard to deal with that head-on because most people feel helpless to do anything about it," says Douglas Vakoch, a clinical psychologist at the California Institute of Integral Studies in San Francisco.
"If we look at the nature of the problem, it is so big it's hard to know what any individual can do in their own life to make a difference," he says. "The tendency when people are confronted with an overwhelming problem is to run away from it, so psychologists are very experienced in dealing with that."
Paul Stern, a researcher at the National Academy of Sciences in Washington, D.C., says people generally want to do the right thing but don't know what it is. And he says they have "mistaken impressions" about what will actually affect energy use.
At the meeting, Stern will present a preview of a report he co-authored that outlines the behaviors that matter most in terms of energy consumption. The report, which will appear in the September/October issue of Environment magazine, is the latest update of a list initially analyzed in 1981.
"One of the first things you think of is turning off lights when you leave a room or changing the thermostat settings in the house. They don't think first of caulking windows or upgrading your furnace," Stern says. "More insulation in the attic and tight windows make more difference than changing the thermostat setting. Having a more fuel-efficient car makes more difference than any amount you're likely to decrease driving."
Because Stern's research was on energy use, he didn't look at recycling. Social psychologist Jessica Nolan studied the issue at the University of Arkansas-Fayetteville.
Nolan, who this fall will be an assistant professor of psychology at the University of Scranton in Pennsylvania, examined global warming, recycling and improper disposal of used motor oil with three studies involving a total of 289 students.
She found that students are not particularly inclined to disapprove of the non-sustainable behavior of others.
"People showed strong approval for other students who recycled. You would hope to see people disapprove of people who don't recycle, but they didn't disapprove," she says.
But, she says, the response was stronger if the activity was perceived as more harmful: More students said they would scold someone if they saw that person improperly disposing of motor oil.
Vakoch says more research is needed to encourage greater sensitivity to the natural world.
"We are recognizing that environmental problems have a tremendous impact on many aspects of our lives, but we need a lot more work," he says. "We can't afford to let this increased environmental concern become just another fashionable trend."
READERS: What has inspired you to adopt more eco-friendly practices? What turns you off to going green? Share your views below:


text:
Our store is open for business, however new health regulations are in place. Tap below to find out more.
> Please Read First <
Click "YES" to delete this section. This process cannot be undone. Are you sure?
Click "YES" to delete this product. This process cannot be undone. Are you sure?
Assistance Required: Pricing for the listed item may have changed since it was added or last updated. The item may also have been discontinued.
Further contact details are available on the Contact Us page.
Stay informed of changes and updates to products as well as useful information specifically related
to this section of our website.
This service is 100% free! Just tap Subscribe once you've entered your name and e-mail address.
Check your e-mail for a verification e-mail. The verification process is one-click process;
once it's complete, you will be signed-up and ready to stay informed.
Absolutely No Junk!
This service is for useful informational only. We won't hassle you with
marketing e-mails or anything that doesn't relate to your area of interest. And you can unsubscribe at any time.
So why not give it a try.
To Unsubscribe
If you're a subscriber, just enter your name and e-mail address and tap Unsubscribe.
You will receive an e-mail containing a link to unsubscribe. And that's it, your name and e-mail will be removed from our system.
The function you are attempting to use has been disabled to prevent potentially harmful information being sent to our server.
Disabled features include:
Copy the link below to paste into your e-mail to share this page