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Posted by Editoress on 01/20/12
Stage 3: Greipel gallops to victory
The Santos Tour Down Under thundered into Victor Harbor today with German sprint sensation Andre Greipel leading home a bunch gallop to win the third stage and reclaim the overall lead.
The Lotto-Belisol rider, who won both the curtain raiser Down Under Classic race on Sunday night and the first stage of the Tour into Clare on Tuesday, was just too fast for his rivals edging out FDJ - BigMat rider Yauheni Hutarovich (BLR) by half a wheel with Norwegian Evald Boasson Hagen (Sky) third across the line.
"This victory is for Jurgen Roelandts who unfortunately supports us from the hospital," said Greipel of his team mate who was injured in the crash at the end of the stage into Clare. "We're nearly three riders down but the rest of the team that is not injured has been awesome today.
The win puts Greipel back into the ochre leader's jersey with an eight second margin over Swiss rider Martin Kohler (BMC). Australian Michael Matthews (Rabobank) finished with the bunch and remains in third place overall at 12 seconds.
"I'm happy to get back into the lead but the time bonus (10 seconds for the stage win) I got again isn't important in my mind," said Greipel who has twice won overall honours but concedes he is unlikely to win a third. " The Willunga stage (Saturday) is too hard for me to win GC this year. With two stage wins, we've already reached our goal. We can't have everything and we just take it day by day."
The stage today departed from the cosmopolitan shopping hub of Unley for a 134.5km route that took in the breath taking countryside of both the McLaren Vale and the picturesque coastal scenes of the Fleurieu Peninsula.
A group of three went down the road in the first five kilometres made up of Russian Eduard Vorganov (Katusha) and Belgians Jan Bakelants (RadioShack-Nissan-Trek) and Thomas De Gendt (Vaconsoleil-DCM). They were soon joined by Ireland's Matthew Brammeier (Omega Pharma - Quickstep).
De Gendt was the only rider in the quartet already on the board in the SKODA King of the Mountain competition so, not surprisingly, he hit out up Sellicks Hill Category 2 climb to claim the maximum ten points ahead of Brammeier, Bakelants and Vorganov. That puts De Gendt in the polka dot jersey with a two point lead over yesterday's stage winner Tasmanian Will Clarke (UniSA-Australia).
The break stretched to a lead of around five minutes but the peloton, after failing to catch Clarke yesterday, judged today's chase to perfection.
The two Jayco intermediate sprints were hotly contested by the top three placed riders with a maximum of six bonus seconds up for grabs and all within 12 seconds of the race lead. De Gendt proved the swiftest of the trio battling for the points and won the dash for the line at both Mt Compass (65km) and Goolwa (89.4km). By then the margin had shrunk to less than two minutes.
"Three of the four riders (in the break) had the same goal and that was to take the second sprint and then after that we just wanted to go back to the peloton," said De Gendt.
After the sprint at Goolwa Brammeier tried a solo attack off the front as the peloton reeled in his there fellow escapees and although he held on for a few more kilometres it wasn't too be his day for victory. Ten kilometres from home the pace was frenetic as the sprinter's jostled for position.
"It was our intention to keep the breakaway in sight with a good gap. The crosswinds have made the race faster. The one kilometre to go mark was the most important point of today's stage," said Greipel. "I told my team-mates 'I need to be in fifth or sixth position at that point'.They did a great job to put me there and I finished it off."
De Gendt's efforts along the road moved him up to fourth overall, 14 seconds off Greipel's lead.
"The legs are not so good but I will try to attack. I think tomorrow is the best for me just to stay in the peloton and then Old Willunga Hill is going to be so hard but I am going to try and be in the front."
Matthews still leads the Cycle Intead Best Young Rider under 26 classification but was a little disapointed with today's finish.
"The boys had a really good lead out for me and I just couldn't really hold the wheel in the last couple of kilometres," said Matthews. "It just got a bit messy and Mark Renshaw [Rabobank team mate] held the lead out but I just wasn't there to finish it."
Tomorrow's BUPA Stage 4 travels 130km from Norwood in Adelaide's eastern suburb's to Tanunda in the Barossa wine growing region. Stage 4 also hosts the Bupa Challenge Tour with more than seven thousand cycling enthusiasts hopping on their bikes to ride the race route. Joining them on the family friendly Tanunda loop will be cycling legend, Eddy Merckx.
Stage 3 Jersey Summary
• Stage Winner - Andre Greipel (Lotto-Belisol) (GER)
• Santos Tour Down Under Leader - Andre Greipel (Lotto-Belisol) (GER)
• Jayco Sprint Leader - Andre Greipel (Lotto-Belisol) (GER)
• SKODA King of the Mountain Leader - Thomas De Gendt (Vacansoleil-DCM) (BEL)
• Cycle Instead Best Young Rider - Michael Matthews (Rabobank) (AUS)
• Brilliant Blend Team Leader - UniSA-Australia
• Hindmarsh Most Aggressive Rider for stage 2 - Thomas De Gendt (Vacansoleil-DCM) (BEL)
Full Stage 3 results
Stage 4: Freire flashes home in Tanunda
Three time road race world champion, Oscar Freire, has won the Bupa Stage 4 of the Santos Tour Down Under in a frenetic sprint into Tanunda, in South Australia's Barossa wine growing region.
The 35 year old Spaniard led home a break of 50 riders who went clear on the final climb of the day leaving overnight leader Andre Greipel (Lotto-Belisol) almost eight minutes behind.
"It was a difficult finale," said Freire. "I knew I had a really good chance to win. The race was hard (so) it was better for me.
"I'm happy to score the team's first victory of the year after joining Katusha," said Freire who is in his first race for the Russian outfit.
The Santos Tour Down Under ochre leader's jersey meantime is back on the shoulders of Swiss rider Martin Kohler (BMC) who finished with the lead group of 49 on today's stage and is a mere two seconds ahead of both Australian Michael Matthews (Rabobank) and Freire who are in second and third place overall respectively.
"I didn't expect to be back in the lead but we dropped Andre Greipel on the climb and then we were riding hard to make the gap bigger," said Kohler. "Tomorrow there will be ten or fifteen riders contesting the win at the top of Willunga Hill. It's going to be very hard and I don't know if I can keep this lead or not but I'm already happy with what I'm doing here.
"Our team BMC feels at home with all the support we get but of course we are the team of Cadel Evans," said Kohler noting the popularity of his Tour de France winning Australian team mate.
Canberra's Matthews was a little disappointed to not be in ochre but was looking on the bright side.
"The jersey I want is ochre and I'll try to get it tomorrow," said Matthews. "It's unfortunate that I missed it today by only two seconds. (But) not having the jersey today takes a lot of pressure off you but it's also better to be ahead of everyone else."
The 130km stage began in the suburb of Norwood and headed into the Adelaide Hills before travelling through the vineyards. A few riders tried to go clear early but the sprinters weren't having any of that because the first of today's two Jayco intermediate sprints was only 25 kilometres down the road at Kersbrook and bonus seconds were up for grabs. Greipel went hard at the line and nabbed the maximum three seconds with Matthews close behind to shave two seconds off his time.
After the sprint the pace settled and a small break went clear. Australian Jay McCarthy (UniSA-Australia) was in the quartet in front and collected the maximum points on offer at the first SKODA King of the Mountain for the day, a category two climb at Smith Hill (30km). Spaniard Ruben Perez Moreno (Euskaltel-Euskadi) was second over the summit with Frenchman Blel Kadri (AG2R la Mondiale) third and Gatis Smukulis (Katusha) fourth.
Smukulis dropped back to the bunch soon after the climb but the remaining three rode on to contest the second Jayco sprint at Mt Pleasant (51km). This time Perez Moreno claimed the points ahead of Kadri and McCarthy. The lead margin hovered around the two minute mark for the next thirty kilometrees or so but as they approached the Menglers Hill category one climb (107km) they were caught by the bunch.
The capture of the trio triggered a pace increase and up Menglers the hill the tempo split the bunch with a more than a third of the peloton powering clear.
Amongst them was Freire who sailed home to win by a bike length from of Gerald Ciolek (Omega Pharma - Quickstep) (GER) who just edged out Italian Daniele Bennati (RadioShack-Nissan) for second on the line.
The Jayco Points classification is now being led by Norwegian Edvald Boasson Hagen (Team Sky) who collected 12 ponts today for fourth place and sits on 36 points, one ahead of Greipel.
"I just try every day to move up on overall GC. It's nice to have the sprint jersey," said Boasson Hagen. "I didn't expect it but that's not the one I'm looking for, I want to win the jersey of the overall classification.
"My team mate [Geraint] Thomas gave me a great lead out but I came off his wheel a bit too early. The battle is still very open."
The SKODA King of the Mountain leader is now newly crowned Australian under 23 road race and time trial champion, Rohan Dennis, (UniSA-Australia) who was first over Menglers today to take his tally to 17 points, five clear of Belgian Thomas De Gendt (Vaconsoleil-DCM).
"I didn't think that I would lead the King of the Mountain because I only had one point from my breakaway on day one," said Dennis. "Tomorrow at the bottom of Willunga it will be all or nothing."
Kadri was named the Hindmarsh Most Agressive rider of the stage. Sky Pro Cycling is the Brilliant Blend leading team.
The Santos Tour Down Under continues tomorrow with the 'Queen' stage. Jayco stage 5 marks the first time the race has finished at the top of a climb with the 151.5km route starting in McLaren Vale and ending atop Old Willunga Hill which the riders will climb twice.
Stage 4 Jersey Summary
• Stage Winner - Oscar Freire (Katusha) (ESP)
• Santos Tour Down Under Leader - Martin Kohler (BMC) (SUI)
• Jayco Sprint Leader - Edvald Boasson Hagen (Team Sky ) (NOR)
• SKODA King of the Mountain Leader - Rohan Dennis (UniSA-Australia) (AUS)
• Cycle Instead Best Young Rider - Michael Matthews (Rabobank) (AUS)
• Brilliant Blend Team Leader - Sky Pro Cycling
• Hindmarsh Most Aggressive Rider for stage 4- Blel Kadri (AG2R la Mondiale) (FRA)
Full Stage 4 results
Courtesy Tour Down Under
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Chicago Fire 1, LA Galaxy 1 | MLS Match Recap
BRIDGEVIEW, Ill. - Landon Donovan continued to show why he should be on the USA plane to Brasil with a wonderful equalizer as the LA Galaxy earned a 1-1 draw with the Chicago Fire at Toyota Park Sunday.
With the tempurature reaching 90 degrees both teams struggled to get into any rhythm in the first half. LA failed to register a single shot, while Chicago had only slightly better opportunities.
Fire forward Quincy Amarikwa had the best look of the opening 45 when he jumped on a defensive error, raced ahead of his mark and shot high as Galaxy goalkeeper Jaime Penedo came off his line.
The visitors showed significantly more attacking intent after the break, although Amarikwa saw his appeals for a penalty waved away by referee Hilario Grajeda after going down under a challenge from substitute Robbie Rogers in the 56th minute.
On the hour, Fire defender Jhon Kennedy Hurtado denied LA's Robbie Keane a certain goal when he found himself through on goal after a penetrating run from Stefan Ishizaki.
The Fire were handed a chance to open the scoring in the 66th minute when sloppy defensive play from the Galaxy saw Amarikwa gain possession before he was taken down by Juninho. Replays showed contact was outside the box, but Grajeda pointed to the spot.
With striker Mike Magee out of the side through injury, captain Jeff Larentowicz stepped up and calmly slotted his well-placed kick low to Penedo's right to put Chicago ahead.
The Fire's lead was short lived and, again, they were to blame for their own downfall as Chris Ritter's pass to Gonzalo Segares was short and allowed Rogers to intercept and drive towards goal. And it was Donovan who was on hand to sweep home the equalizer in emphatic style when he met Rogers' cross at the far post and shot past Fire goalkeeper Sean Johnson to earn the Galaxy a point and ensure the Fire were held for the seventh time in 12 games.
Next up for the Fire is a trip to the Colorado Rapids on Wednesday, while the Galaxy host LA rivals Chivas USA on Sunday.
MLSsoccer.com Men of the Match
|What We Saw
|Robbie Rogers
|Stepped right into right back spot, denying Chicago any chances and then served up the perfect assist.
|Bakary Soumare
|Stood steady on defense and kept the back four in line, not allowing LA to get behind, save one time.
|Jaime Penedo
|Didn't have to do the spectacular, but was in the right place at right time and read the game well to keep LA in it

subset: commoncrawl


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You know how you sometimes enter into something thinking you're going to totally "get it" because you already think you know exactly where you're headed and how to get there?
That was me, about a month ago, when God showed me my One Word for this year. "Showed," as in "made it known to me while I was reading a Bible verse I had read about 67 quizillion times before, but never actually LOOKED at before." It is a word which has multiple meanings, and - to be transparent - 3/4 of them seemed to totally sync up with what I thought I needed. It seemed to make total sense to me in terms of me making peace with my past. It seemed to be a way for me to reframe, to own, and to honor the struggles, the loss, and the pain I still sometimes see and feel as I look behind me to see where all I have come from.
It seemed easy.
Which, of course, meant that it was only a matter of time before God blew my 'tude out of the water.
One of the only translations of my One Word - shalam - that felt a little like it belonged in the "one of these things is not like the other" song was that in addition to what I wanted the word to translate to, it also could be translated to mean "to be sound." A fellow blogger left a comment that the "to be sound" translation of shalam struck her for some reason moreso than the other definitions. I kinda glossed over her comment at first, thought, "That's nice," and moved on. ...rather, I tried to move on, because my mind kept circling back to this.
"To be sound."
Basically, in one fell swoop, God managed to use her to completely derail the journey that I thought I was supposed to be One Wording it with, and instead she made me start to actually ENGAGE with this friggin' word and not just pull it out like a magic charm/easy-peasy quotable Bible verse when I want to just throw some Jesus into my mind. This comment made me...start. Start. To. Think.
Therefore, in the best Dr. Doofenschmirtz voice I can mimic: "CURSE YOU, TRACEE THE PERSIKO!"
(Just kidding; Tracee managed to give me just the right dose of challenge and support with her comment. She is an INCREDIBLY talented writer and who consistently pulls some massively deep thoughts out. I am continually challenged and inspired by what Tracee writes - and you should seriously check out her blog, both hyperlinked here and noted in the blogroll in the sidebar.)
Looking closer at this definition, "to be sound" relates to something much deeper than just the healing I thought I was looking for. "Sound" as an adjective can mean:
• free from injury, damage, defect, disease, etc.; in good condition; healthy; robust: a sound heart; a sound mind.
• competent, sensible, or valid: sound judgment.
• having no defect as to truth, justice, wisdom, or reason: sound advice.
• of substantial or enduring character: sound moral values.
• following in a systematic pattern without any apparent defect in logic: sound reasoning.
• uninterrupted and untroubled; deep: sound sleep.
• free from moral defect or weakness; upright, honest, or good; honorable; loyal.
• having no legal defect: a sound title to property.
• theologically correct or orthodox, as doctrines or a theologian.
(Emphases mine.)
Well, poop.
See, here and I thought that I was simply just going back and revisiting Joel 2:25 - "I will repay you for the years the locusts have eaten – the great locust and the young locust, the other locusts and the locust swarm – my great army that I sent among you." - and discovering that redemption encompasses more than I ever thought possible. In that regard, I was correct (or, if I may, sound) in my reasoning: I will be/am being placed/have been placed in a covenant of peace over my past. I am/have been/am being made whole over and over and over again. I am/have been/am in the process of being complete.
But this is showing me that also, apparently under the Law - which, y'know, Christ came to complete and all - I have no defect. This flies in the face of the words and labels people tend to place upon those of us who have a past that doesn't mesh up with the image of perfection that believers are "supposed" to have.
This is showing me that I should not be troubled by my past.
This is showing me that I am valid. That my past - my story - is valid.
This is showing me that I am not to passively just accept the grace given to me, but to actively work IN it. "Yay, I'm forgiven! Now let's all go on to Cold Stone! La la la!" should not be how I operate.
I am sound. I am being made sound. My life is sound.
Going through shalam is gonna kick my butt this year. I can just feel it.
And I welcome this forthcoming bruised tushie.
It beats having a bruised heart.


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E-Bike category has no segments
I hired an e-mtb and rode on some of my regular trails.
I uploaded as an e-bike which to my disappointment had a completely different set of segments.
It would be far better if it included e-bikes (but marked as e-bike) in the main section of Strava so that we can ride our favourite segments and rate them against our own times and our followed and followers.
If they are in the main section you could have an option for people to either mask or un-mask e-bike depending on their feelings about them,


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The Acrobat Forms Author Plug-in 3.5 Update enables Acrobat Exchange 3.01 users to create forms with the following new features:
-- JavaScript can be used for performing actions such as client-side field validation and calculations; it also allows greater format control and improved form intelligence.
-- Export Forms allows users to save a form and its data to a local hard drive. This feature is only available in Acrobat 3.0 and Acrobat Exchange VPP.
-- Dynamic Page Templates allow the creator to specify a first, last, and any number of middle pages to support form applications such as database publishing and high-end printing of bills and other forms.
-- Authoring Enhancements, such as the new layout grid, make it easier to align form fields. Other enhancements include support for multiple field selection and editing of field properties, which reduce creation and editing time.
-- Embedded PDF Graphics Support allows the user to embed PDF graphics within forms and then submit those graphics to a Web server.
-- Send Acrobat Forms data to a database. Acrobat Forms work with Web servers via standard Web server CGI scripts. In fact, a PDF form can replace HTML forms with little or no change to existing scripts. If your Web server software can connect to your corporate database, you should be able to write CGI scripts that take form data and populate your database and vice versa.
-- The Acrobat FDF Toolkit, which allows you to easily create and parse the Acrobat Forms Data Format (FDF), is available through Adobe Developer Relations on our Web site. It allows you to manipulate form information as a data tree, and extract and populate forms with graphical data. The FDF Toolkit comes as a C library with Perl and ActiveX(TM) wrappers on a variety of platforms.
Acrobat Reader 3.01 users should install the Acrobat Forms Fill-in Plug-in 3.5 Update to use the new forms features in PDF files that were created using the Forms Author Plug-in 3.5 Update.
|Acrobat Exchange
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|File Size
|Proceed to Download
Adobe Acrobat Exchange 3.01 for Macintosh for Dutch, English, French, German, Italian, Spanish, and Swedish language versions only
1. Double-click the Acrobat Forms Author Installer icon.
2. Follow the on-screen instructions to complete the installation.
More details about the new features are included in the Readme document that is created after installing.
License agreement
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> PLEASE CHOOSE ONE <No Rice 不要飯 White Rice 白飯 Brown Rice 黃飯 Egg Fried Rice 蛋炒飯 Veggie Fried Rice 菜炒飯 Chicken Fried Rice 雞炒飯 Pork Fried Rice 叉燒炒飯 Pork & Pineapple Fried Rice 鳳梨叉燒炒飯 Beef Fried Rice 牛炒飯 ($1.50)Shrimp Fried Rice 蝦炒飯 ($1.50)Plain Lo-Mein 淨撈面 ($1.00)Pork Lo-Mein 叉燒撈面 ($1.50)Chicken Lo-Mein 雞撈面 ($1.50)Veggie Lo-Mein 菜撈面 ($1.50)Beef Lo-Mein 牛撈面 ($2.00)Shrimp Lo-Mein 蝦撈面 ($2.00)
> PLEASE CHOOSE ONE <No side Wonton Soup ($0.50)Hot & Sour Soup ($0.50)Egg-Drop Soup ($0.50)Chicken Rice Soup ($0.50)Chicken Noodle Soup ($0.50)Egg Roll ($0.50)Veggie Spring Roll ($0.50)Beef Spring Roll ($0.50)Asian Spring Roll ($0.50)Can Soda ($0.50)Bottled Water ($0.50)
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Heyday Bed® with Microsuede® has been tested and certified for safety by Oeko-Tex, a 3rd party ecological certifier that rigorously tests every part of this durable and versatile dog bed for over 100 potentially harmful substances.
Heyday dog beds were made to resist all those messes your dog creates! Of course, in our testing, it wasn't always the dog that created the mess. With a quick wipe or toss in the wash, this dog bed is as good as new again. Made in the USA
Choose Options For Sizes


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Wal-mart Plans New Neighborhood Market in El Cajon
Wednesday, December 25, 2013
Wal-Mart Stores Inc. plans to open a new location of its small-format Walmart Neighborhood Market in El Cajon during the first half of 2014.
The store is planned on Second Street in the Town and Country Village Shopping Center and will employ about 65 people, the retailer said in a statement.
Wal-Mart (NYSE: WMT) plans to reuse a retail space of about 40,000 square feet, which has been vacant for almost three years.
Wal-Mart debuted the Neighborhood Market concept in 1998 and now operates about 300 nationwide. The stores sell fresh produce, meat and dairy products, frozen foods and grocery staples, and have a full-service pharmacy.
Arkansas-based Wal-Mart operates more than 10,800 stores in 27 countries. In San Diego County, the retailer has 24 locations, including 12 general-merchandise stores, nine supercenters, two Neighborhood Markets and one Sam's Club.


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Grilling Fun
Couture Baby Shower Invitations
Grilling Fun, Item# SI7713B
Note: Sparkles are simulated and will not light up.
Grilling Fun, Item# SI7713B
Note: Sparkles are simulated and will not light up.
Grilling Fun Thank You Card
Shower Poem Insert Card
Shower Notes of Advice for a New Mommy
Photo Round Sticker Favor Label
Photo Rectangular Sticker Favor Label
Our Baby Shower invitation, "Grilling Fun", features a fun BBQ themed design with grilling tools and some floral elements. Complementary graphics are printed on the back of the card. Choose from multiple color options to match your personal style and preference.
*Matching items available upon request.*
You will be able to select the typestyle and ink colors to use for your personalized text during the design process. Start by clicking on the green 'Personalize and Continue' button. We recommend using the default typestyle and ink colors.
|Estimated Postage Required:
|$0.55 stamp - if other items are not added into the Envelope. Click here for additional postage information.
|Item Type:
|Flat Card
|Card Dimensions:
|5.25" x 7.5" (W x H)
|Printing Process:
|Digital Press
|Paper Weight:
|Multiple Stock Options
|Typestyle Shown:
|Technical and Redressed
|Matching Ink Color:
|Black and Tangerine
|Your choice of White or Cream Envelopes included. Printed return address and/or Calligraphy is available for an additional cost.
|Inner Lined Envelopes:
|Inner Lined Envelopes available for an Additional $.40 each. Choose from 20 different colors.


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Maxomorra Purple Pansy Tank Top
Maxomorra Purple Pansy Tank Top
This Maxomorra Purple Pansy Tank Top is light turquoise with a pattern of pretty pansies and a plum trim. This organic cotton vest for children is perfect as underwear, a summer top and sports kit. Team up with matching underpants for a super-Scandi underwear set and check out the full Maxomorra range at Babipur for a stylish organic outfit.
Made with super-soft GOTS organic cotton under fair trade conditions, Maxomorra clothing is gentle on delicate skin, eczema-friendly and has top green credentials too. We love the colours, fun designs and commitment to sustainability – a little bit different to what you will find on the high street.
Made with 95% GOTS certified organic cotton and 5% elastane.
Maxomorra European size guide
- 1-2 months - 50-56
- 3-6 months - 62-68
- 9-12 months - 74-80
- 18-24 months - 86-92
- 3-4 years - 98-104
- 5-6 years - 110-116
- 7-8 years - 122-128
- 9-10 years - 134/140
Maxomorra "Play" range at Babipur, classic Maxomorra style! Big, bold characters and theme prints on brightly coloured backgrounds. Happy prints that inspire creativity and play. Taking inspiration from Smaland Sweden, the homeland of Maxomorra, characterised by small farms, forests, lakes and tourists.
Founded in 2008 Maxomorra's signature Scandi repeat prints have taken the ethical fashion world by storm. Loved for their bright and eye catching designs and high ethical credentials. Maxomorra use GOTS certified organic cotton ensuring organic standards and fair trade throughout the supply chain. There's something for everyone from this super Swedish clothing brand for babies and kids up to 10 years. Choose your favourite prints, mix and match with block colours or pick a contrasting print. Here at Babipur, we just love Maxomorra.
Fast delivery & great service
We ship our products worldwide using Royal mail and fast courier services. We have lots of regular shoppers from all around the world.


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A frequent cause of chest pain, pericarditis may also lead to life-threatening complications.
Pericarditis is an inflammation of the pericardium, the sac that surrounds and holds the heart in place.
The condition may be acute (short-term) or chronic (long-term).
A sharp, stabbing chest pain, which may feel like heart attack pain, is the most common symptom of pericarditis.
It's unclear just how common pericarditis is in the general population.
It may be responsible for around five percent of all non-heart attack chest pain cases that end up in accident and emergency departments, according to a report in the journal The Lancet.
What's more, evidence of pericarditis has been found in about one percent of autopsy studies, suggesting that the inflammation might frequently be present in people without causing noticeable symptoms.
Pericarditis can occur in men and women of all ages, but it most frequently affects men aged 20 to 50, according to the National Heart, Lung, and Blood Institute (NHLBI).
Additionally, about 15 to 30 percent of people who are treated for pericarditis may get it again weeks or months later, according to the NHLBI.
In many cases, it's unknown what causes a person to develop acute or chronic pericarditis.
In fact, the cause of pericarditis is unknown in up to 30 percent of cases, according to The Lancet report.
However, viral infections, such as from coxsackie viruses, influenza, and HIV, are the most common or identifiable causes of pericarditis.
Infections from bacteria, fungi, parasites, and other organisms (such as tuberculosis) can also cause pericarditis.
Scientists believe chronic pericarditis is most often caused by autoimmune disorders, such as lupus, scleroderma, and rheumatoid arthritis.
Other causes of pericarditis include:
- Cancer, including leukemia
- Tuberculosis
- Kidney failure
- Traumatic and radiation therapy-based injuries
- Various drugs, such as anti-seizure, blood-thinning, and anti-arrhythmia medications
Pericarditis After a Heart Attack
Pericarditis may develop after a heart attack.
In some cases, the inflammation occurs in just one to three days after the heart attack, as the body tries to clean up the diseased heart tissue (causing swelling and inflammation in the process).
Pericarditis may also develop several weeks or even months after a heart attack or other heart trauma.
This late pericarditis is called Dressler's syndrome, also known as post-cardiac injury syndrome or postcardiotomy pericarditis.
It's thought to be a kind of autoimmune issue, in which the immune system erroneously attacks healthy heart tissue.
Chest pain and fever are the most common symptoms of Dressler's syndrome.
Complications of Pericarditis
Pericarditis may result in one of two serious complications: cardiac tamponade and chronic constrictive pericarditis.
Cardiac tamponade is considered a medical emergency and, if left untreated, can quickly become fatal.
It develops when too much fluid builds up between the heart muscle (myocardium) and the pericardium, putting obstructive pressure on the heart that prevents it from working properly.
Cardiac tamponade can cause numerous symptoms, including:
- Anxiety
- Breathing problems and chest pain
- Dizziness and fainting
- Swelling of the abdomen
- Drowsiness
- Weak pulse
A long-term, rare disease, chronic constrictive pericarditis may also be life-threatening if left untreated.
It slowly develops when pericarditis causes scar-like (fibrous) tissue to form on the pericardium, making the sac thick, stiff, and rigid.
The scarred tissue contracts over time, preventing the heart from fully stretching and filling with blood.
Chronic constrictive pericarditis can cause weakness and fatigue, difficulty breathing, and swelling in the abdomen and extremities.
Learn More About Pericarditis Symptoms
Editorial Sources and Fact-Checking
- What Is Pericarditis?; National Heart, Lung, and Blood Institute.
- Troughton et al. (2004). "Pericarditis." The Lancet.
- Pericarditis; MedlinePlus/NIH.
- Pericarditis - after heart attack; MedlinePlus/NIH.
- Pericarditis - constrictive; MedlinePlus/NIH.
- Cardiac tamponade; MedlinePlus/NIH.


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text:
1) The worst blindness is straying form the straight path after receiving true guidance.
2) Among the virtues of a believer are cleanliness in dress, contentment and thankfulness when one does not have enough.
3) A believer wishes for others what he wishes for himself.
4) When your good deeds please you and your bad deeds cause you grief, you are a believer.
5) The believers are like the parts of a building strengthening one another.
6) Look at those who are less fortunate than you so that you are not ungrateful for the things which you have been blessed with by Allah.
7) Allah Almighty has cursed the one offering the bribe, the one who is receiving it as well as the go-between.
8) If you are a trustworthy, honest and truthful businessman, you will rise up with the martyrs on the Day of Judgment.
9) The greatest form of charity is the effort to help a poor man, made in secret by one who is poor himself.
10) When Allah Almighty blesses someone with children, and they give their children their love, and meet their parental obligation, Allah saves them from the fire of hell.
11) When you see a coffin passing by stand up (out of respect) whether it is a Muslim or a non-Muslim.
12) Man is tested according to his level of faith. If his faith is firm, his trials increase in severity.
13) For everything there is a way to purify it, and for the body it is fasting.
14) The Almighty forgives him who forgives others.
15) Whoever buys a gift and brings it home to his family he is like one who has given charity.
16) Whatever hardship a person faces – even if it is as small as the prick from a thorn -Allah makes it atonement for his sins.
17) The greatest kin of holy war is to speak up for truth in the face of a ruling authority that deviates from the right path.
18) Whoever follows a path seeking knowledge, Allah Almighty will make that path easy for them.
19) The best thing you can do is to serve your mother, then your mother, then your mother, and then you father, then your relatives.
20) The one who cares for a widow or the needy is like the one who fasts all day and prays all night.
21) Beware of the prayer of the victim of an injustice, for there is no barrier between him and Allah Almighty.
22) Allah Almighty has no regard for a prayer in which a man's heart is not present with his bodily actions.
23) Previous nations were destroyed because they let off people with high rank and punished the poor and the helpless.
24) The superiority of a learned man over the one engaged only in ritual worship is like that of a full moon over the stars.
25) What comes to you in my name but is in conflict of theQuran cannot be from me.
26) You have rights over women and women have rights over you.
27) Before speaking the salaam should be said. (Tirmizi)
28) Spread the salaam amongst yourselves. (Muslims)
29) Whoever sends one Durood upon me, Allah sends ten blessings (Durood) upon him. (Tirmizi)
30) My intercession is for the big sinners in my Ummah. (Tirmizi)
31) Cleanliness is a part of the Faith. (Tirmizi)
32) Dua is the kernel of Ibaadat. (Tirmizi)
33) Actions depend on their intention. (Bukhari and Muslim)
34) A Muslim is he from whose tongue and hands a Muslim is safe. (Al-Bukhari)
35) The best of you is the one who learned and taught the Quran. (Al-Bukhari)
36) Modesty is a part of faith. (Muslim)
37) Visit the graves because they remind one of the Akhirah. (Muslim)
38) A Muslim is a brother of a Muslim. (Al-Bukhari)
39) To learn the Knowledge of the Deen is fard upon every Muslim man and woman. (Ibn-e-Majah)
40) Salah is a pillar of the Deen. (Tabarâni)
41) Whoever is deprived of tenderness (unto others) is deprived of good. (Muslim)
42) Relate on my behalf even if it is an Ayah. (Al-Bukhari)
43) Whoever remains quiet attains salvation. (Tirmizi)
44) The influence of the gaze is Haq (the Truth). (Al-Bukhari)
45) Religion is the name of well-wishing. (Al-Bukhari)
46) Announce your Nikah (marriage). (Tirmizi)
47) Nikah (marriage) is my Sunnah. (Ibn-e-Majah)
48) Whoever turns from my sunnah is not from me. (Al-Bukhari)
49) Dua rids calamity.
50) I distribute (to people) and Allah gives. (Al-Bukhari)
51) To be ashamed (of sins) is repentance. (Ibn-e-Majah)
52) It is because of those Awliya (Friends) of Allah that it rains and it is because of them that Rizq (sustenance) is given.
53) Fasting is a shield (from sins). (Tirmizi)
54) The best sadaqah is that a Muslim man learns knowledge (of the Deen) and then teaches it to his Muslim brothers. (Ibn-e-Majah)
55) "Whoever innovates a good innovation in Islam has its reward and the reward of those who would practice upon it until the Day of Judgment – without lessening the rewards of those who practice with it. The one who innovates the innovation of misguidance, would take the sin for it and the sin of those who practice upon it until the Day of Judgment–without lessening the sin of those who practice with it.†(Muslim, as-Sahih, 2:705)
The Quran 50:06 (Surah Qaf) "Have they not observed the sky above them, how We have constructed it and beautified it, and how there are…
The Quran 24:27 (Surah an-Nur) "Do not enter houses other than your own, until you seek permission and greet the inhabitants.â€
Al-Hasan ibn Ali reported: The Messenger of Allah, peace and blessings be upon him, said:
Leave what makes you doubt for what does not make you doubt. Verily, truth brings peace of mind and falsehood sows doubt.


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I'm new, and a student who is oddly enough a little stumped. Not being doing C++ for long so I probably have a lot of Bad Code and it probably looks ugly to anyone who has been doing it for a few months. I've noticed around here that using namespace std etc isn't exactly good practice but if I take a code back to my tutor without it I'll get sent back to change it and put it back in. So just to explain why I'm using it, I'm keeping a note in my head that outside of my classroom it isn't a good idea. So now I'm done apologising for this, I'll get to why I've been up till 3am.
For the life of me, I can't work out how to call the plant with the longest Latin name. I've been at it for a few hours.
As I'm a student, and I'm very much pointing this out so no one accuses me down the line of getting other people to do my homework! I'm not expecting someone to turn up and give me the exact code to fix my problem. Being pointed in the right direct or given a bit of code I could work with would be awesome.
Thank you for taking time out to read this, and double thanks for any help!
Code:// Session6_4.cpp : Defines the entry point for the console application. //For you to do... #include "stdafx.h" #include <iostream> #include <iomanip> #include <string> using namespace std; const int MAXPLANTS =6; //Always use this instead of magic numbers in code! struct Plants { string CommonName; string LatinName; double Height; double Price; }; int main() { Plants ListPlants[MAXPLANTS] = { {"Bluebell", "Endymion Non Scripta", 0.3, 1.25}, {"Snowdrop", "Galanthus Nivalis", 0.15, 1.55}, {"Tenby Daffodil", "Narcissus Obvalis", 0.4, 3.25}, {"Winter Aconite", "Eranthis Hyemalis", 0.1, 2.0}, {"Dogs Tooth Violet", "Erythronium Dens Canis", 0.15, 5.95}, {"Summer Snowflake", "Leucojum Aestivum", 0.3, 4.50} }; int IndexMostExpensive; double PriceMostExpensive; IndexMostExpensive=0; PriceMostExpensive = ListPlants[IndexMostExpensive].Price; ///Header Display/// cout<<setfill(' ')<<setw(20)<<"Common Name"<<(' ')<<setw(20)<<"Latin Name"<<(' ')<<setw(20)<<"Height"<<(' ')<<setw(10)<<"Price"<<endl<<endl; for (int i=0; i<MAXPLANTS; i++) { //cout<<ModelName[i]<<"\t"<<Registration[i]<<"\t"<<Price[i]<<"\t"<<EngineSize[i]<<endl; cout<<setfill(' ')<<setw(20)<<ListPlants[i].CommonName; cout<<setfill(' ')<<setw(30)<<ListPlants[i].LatinName; cout<<setfill(' ')<<setw(10)<<ListPlants[i].Height; cout<<setfill(' ')<<setw(10)<<ListPlants[i].Price; cout<<endl<<endl; if (ListPlants[i].Price>PriceMostExpensive) { IndexMostExpensive =i; PriceMostExpensive = ListPlants[i].Price; } } cout<<endl<<"Most expensive Plant is "<<ListPlants[IndexMostExpensive].CommonName<<" at a price of "<<ListPlants[IndexMostExpensive].Price<<endl; cout<<"The Latin name being "<<ListPlants[IndexMostExpensive].LatinName<<" and a height of "<<ListPlants[IndexMostExpensive].Height<<endl; return 0; }


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California tribe buries 5 from shooting rampage
- Details
- Parent Category: News
- Category: Social Issues & Criminal Justice
- Published: 14 December 2012
By TRACIE CONE
PORTERVILLE, Calif. (AP) - December 2012
A California tribe said Dec. 12th it will hold candlelight vigils for the rest of the week to honor five reservation residents who were slain last weekend.
Tribal Chairman Neil Peyron of the Tule River Indian Reservation called the killings ''one of the most horrific losses our community has ever faced.''
Authorities suspect Hector Celaya killed his 8-year-old daughter, his mother, her two brothers, and wounded his young son on Dec. 8th. Hours later Celaya was shot by police and died at a hospital.
Andrew Celaya, 6, remained in critical condition at Community Medical Center in Fresno. Linea Celaya, 5, was in serious condition.
No motive has been established, though police said Hector Celaya, a former custodian at the tribe's Eagle Mountain Casino, had been involved in custody disputes with the mother of his children.
The violence has shaken this peace-preaching tribe, which teaches its members that love for family is above all.
Murder is unheard of on the reservation, said Mike Blain, chief of the Tule reservation's small police department. He was at a loss to say what prompted the violence.
Peyron said in the statement that the candlelight vigil will begin the healing process.
Court records show that Celaya, a former custodian at the reservation casino, had spent time in jail in 2008 after pleading no contest to an assault and battery charge, the Fresno Bee reported.
He was facing a possible return to jail after recent arrests for investigation of drunken driving and drug use, the newspaper reported (http://bit.ly/S135Pv ) Tuesday.
Blain said his department would work to aid the healing of the tightknit community of about 800 people.
''We needed to go back and find what brought us to this. Did we miss something? Did the community or family miss something?'' he said from his office in a doublewide modular home.
Irene Celaya, 60, and her brother Francisco ''Frank'' Moreno, 61, were killed in a travel trailer at the compound where the family lived. Bernard Moreno, 53, was found slain in an outbuilding set up as a bedroom.
Frank Moreno was enrolled as a tribal member, as were the children. Peyron said the other family members were a part of the tightknit community.
People on the reservation described Frank Moreno as a gregarious guy who was excited this month about winning a raffle at an event honoring tribal elders.
The Tulare County Sheriff's Department received a call in April call from the mother of Hector Celaya's children who accused him of driving while intoxicated with the children in the car. Blain said the accusation was unfounded and part of the child custody dispute.
He referred the case to the tribe's version of Child Protective Services. What happened from there is private.
The Tule reservation spreads across 56,000 acres in California's Central Valley. The area about 20 miles east of Porterville rises to an elevation of 7,500 feet in the Sierra Nevada, and its steep and winding roads make travel slow.
Modular homes and trailers are built onto hillsides that overlook the Tule River canyon. On grassy hillsides, herds of paint horses graze alongside the occasional steer.
''The community is a peaceful one, and the tribe tries to teach children to be nonviolent,'' said Rhoda Hunter, the tribal council secretary. ''We teach our children to not even kill insects.''


text:
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Whenever we needed money, we'd rob the airport. To us, it was better than Citibank.
— Henry Hill, "Goodfellas"
John F. Kennedy International Airport cargo building 261, site of the 1978 Lufthansa heist and a key plot element in Martin Scorcese's "Goodfellas," is back in the news again, thanks to another robbery: The theft of thousands of iPads.
The New York Post reports that on Monday night, a pair of thieves used one of the airport's own forklifts to steal two pallets of iPads. Some 3,600 iPads were stolen, worth $1.5 million. And the thieves might have made off with more, had they not been confronted by an airport worker. The shipment they pilfered was five pallets total.
Authorities suspect that, like the 1978 Lufthansa heist, led by the infamously paranoid Jimmy the Gent, the 2012 iPad escapade may have been an inside job.
JFK Cargo Airport Services did not respond to a request for comment. Apple declined to provide one, as well.
Update: An earlier version of this article stated that the devices stolen were iPad minis, as reported by the New York Post.


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The Android Profiler in Android Studio 3.0 and higher replaces the Android Monitor tools. The Android Profiler tools provide real-time data to help you to understand how your app uses CPU, memory, network, and battery resources.
For details about each of the profilers, see the following:
- Inspect CPU activity and traces with CPU Profiler
- Inspect the Java heap and memory allocations with Memory Profiler
- Inspect network traffic with Network Profiler
- Inspect energy usage with Energy Profiler
The Android Profiler is compatible with Android 5.0 (API level 21) and higher.
See the following video for an introduction to the Android Profiler.
To open the Profiler window, choose View > Tool Windows > Profiler or click Profile in the toolbar. If prompted by the Select Deployment Target dialog, select the device on which to profile your app. If you've connected a device over USB but don't see it listed, ensure that you have enabled USB debugging. If you're using the Android Emulator or a rooted device, the Android Profiler lists all running processes, even though they might not be debuggable. When you launch a debuggable app, that process is selected by default.
Android Profiler continues to collect profiling data until you disconnect the device or click End Session.
1 Android Profiler shows the process and device currently being profiled.
2 In the Sessions pane, choose which session to view, or start a new profiling session.
3 Use the zoom buttons to control how much of the timeline to view, or use the Attach to live button to jump to the real-time updates.
4 The event timeline shows events related to user input, including keyboard activity, volume control changes, and screen rotations.
5 The shared timeline view, which includes graphs for CPU, memory, network, and energy usage.
This shared timeline view only shows the timeline graphs. To access the detailed profiling tools, click the graph that corresponds to the performance data that you want to inspect. For example, to access tools to inspect the heap and track memory allocations, click the Memory graph.
Not all profiling data is visible by default. If you see a message that says "Advanced profiling is unavailable for the selected process," you can enable advanced profiling in your run configuration to view the additional data.
You can save Profiler data as sessions, which are retained until you quit Android Studio. By recording profiling information in multiple sessions and switching between them, you can compare resource usage in various scenarios.
To start a new session, click the Start a new profiling session button and select an app process from the dropdown menu that appears.
When you record a trace or capture a heap dump, Android Studio adds that data (along with your app's network activity) as a separate entry to the current session.
To stop adding data to the current session, click Stop the current profiling session .
To import a trace exported from a previous run of Android Studio, click Start new profiler session and choose Load from file.
Enable advanced profiling
To show you advanced profiling data when running a device with Android 7.1 or lower, Android Studio must inject monitoring logic into your compiled app. Features provided by advanced profiling include the following:
- The event timeline on all profiler windows
- The number of allocated objects in Memory Profiler
- Garbage collection events in Memory Profiler
- Details about all transmitted files in Network Profiler
To enable advanced profiling, follow these steps:
- Select Run > Edit Configurations.
- Select your app module in the left pane.
- Click the Profiling tab, and then check Enable advanced profiling.
- Build and run your app again.
The advanced profiling configuration makes the build process slower, so you should enable it only when you want to start profiling your app.


text:
ATK Awarded Production Contract for the U.S. Navy's Multi-Option Fuze
ATK's Multi-Option Fuze Provides Increased Mission Capability for U.S. Navy's 5-inch Gun Ammunition
Five-Year Production Contract to be Performed at Allegany Ballistics Laboratory in Rocket Center, W. Va.
Dec 06, 2012, 08:00 ET
ARLINGTON, Va., Dec. 6, 2012 /PRNewswire/ -- ATK (NYSE: ATK) announced that it received a five-year, Indefinite Delivery, Indefinite Quantity (IDIQ) contract from the U.S. Army Contracting Command for the production of the MK 437 Multi-Option Fuze, Navy (MOFN). The contract has a maximum total value of $84.1 million. ATK has received the first order on this contract, for approximately $13 million. Deliveries are scheduled to begin in November 2013.
The MOFN increases the overall mission capability of 5-inch gun ammunition used on U.S. Navy ships by providing proximity, precision time, delay and point detonating impact functions in a single fuze. The inductive fuze setting feature also optimizes MOFN for use with automated ammunition handling equipment. MOFN will be used on projectiles fired in the MK 45 Single Lightweight Gun Mount on U.S. Navy cruisers and destroyers.
"ATK is pleased to add MOFN to our portfolio of fuze production programs. MOFN leverages ATK's design, development and production experience, providing the U.S. Navy with an affordable, reliable fuze for its 5/54 caliber ammunition," said Dave Fine, ATK's Director of Fuzing and Warhead programs.
"ATK has a strong program and manufacturing team dedicated to producing MOFN for the U.S. Navy," said Cary Ralston, vice president and general manager of ATK Missile Products Division. "This award reflects the tremendous dedication and commitment of our highly-skilled workforce and our industry partners."
Production of this fuze will occur at the Allegany Ballistics Laboratory (ABL) facility in Rocket Center, W. Va. ABL is a U.S. Navy-owned, ATK-operated facility specializing in advanced manufacturing technologies for a variety of programs supporting current and future U.S. industrial base needs in advanced fuzing and integration, conventional munitions assemblies, solid rocket motor propulsion, and advanced material structures.
ATK is an aerospace, defense, and commercial products company with operations in 21 states, Puerto Rico, and internationally. News and information can be found on the Internet at www.atk.com.
Certain information discussed in this press release constitutes forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995. Although ATK believes that the expectations reflected in such forward-looking statements are based on reasonable assumptions, it can give no assurance that its expectations will be achieved. Forward-looking information is subject to certain risks, trends and uncertainties that could cause actual results to differ materially from those projected. Among those factors are: changes in governmental spending, budgetary policies and product sourcing strategies; the company's competitive environment; the terms and timing of awards and contracts; and economic conditions. ATK undertakes no obligation to update any forward-looking statements. For further information on factors that could impact ATK, and statements contained herein, please refer to ATK's most recent Annual Report on Form 10-K and any subsequent quarterly reports on Form 10-Q and current reports on Form 8-K filed with the U.S. Securities and Exchange Commission.
Media Contact:
Investor Contact:
Linda Burcham
Steve Wold
Phone: 540-231-4748
Phone: 952-351-3056
E-mail: [email protected]
E-mail: [email protected]


text:
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text:
Corded Mouse M500
Precision laser mouse
Corded Mouse M500
Precision laser mouse
Free shipping on orders GBP39.00 and over.
Key Features
Hyper-fast scrolling
In free-spinning mode you can coast smoothly through the longest documents and Web pages. In click-to-click mode you can step precisely through spreadsheets, photo albums or playlists.
Precise laser tracking
Experience smoother cursor control on virtually any surface. Work faster and more accurately than with an ordinary optical mouse.1
Comfortable, contoured design
Soft side grips and a contoured design support your hand naturally for all-day comfort and confident control.
Two thumb buttons
The thumb buttons come programmed to let you move back and forth through Web pages or photo albums, but can be configured to do exactly what you want them to.2
Plug-and-play setup
Your mouse works right out of the box. No installation hassles. No software required. Just plug the cord into a USB port and you're good to go.
Additional Features
Superior scrolling. Powerful pointing
Our Hyper-fast scroll wheel and a precise laser sensor make this mouse one very capable companion.
Hour-after-hour comfort
Perfectly sized and subtly contoured, the sculpted design gives you the support you need for work or for play.
Extra control right where you need it
Two customizable thumb buttons make it simpler and faster to get things done.
- Height x Width x Depth:
- 126 mm x 69 mm x 42 mm
- Weight: 144 g
- Cable Length: 180 cm
Mouse Dimensions
System Requirements
- Windows® XP, Windows Vista®, Windows 7, Windows 8, Windows 10
- USB port
- Mac OS X 10.4 or later
- USB port
Windows-based computer
Mac computer
Chrome OS™
Technical Specifications
Tracking technology: Invisible laser
Sensor Resolution: 1000
Number of buttons: 7
Scroll Wheel (Y/N): Yes (with Hyper-Fast Scrolling)
Tilt scroll function (Y/N): Yes
Supported OS:
- Windows Vista, Windows 7, Windows 8, Windows 10
- Mac OS X 10.5 or later
- Chrome OS
Interface: USB
certified Works With Chromebook 3
Product Origin: China
Package Contents
- Logitech® Corded Mouse M500
- Quick-start guide
Warranty Information
3-year Limited hardware warranty
Part Number


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Now, a study we have been following, has yielded great results- especially if you have triple negative breast cancer. We recommend Vitamin D supplementation no matter what your receptors are and suggest that women who do not have breast cancer also supplement to keep their D levels in good range.
Vitamin D Holds Promise in Battling a Deadly Breast Cancer
Wed, 2013-01-23 11:34
In the recent breakthrough, which was funded in part by a $500,000 Department of Defense grant, Gonzalo's lab identified one pathway that is activated in breast cancers with the poorest prognosis, such as those classified as triple-negative. These cancers often strike younger women and are harder to treat than any other type of breast cancer. Women who are born with BRCA1 gene mutations are at increased risk for developing breast and ovarian cancers within their lifetime, and the tumors that arise are frequently the triple-negative type. Although chemotherapy is the most effective treatment for triple-negative breast cancer, it has profound secondary effects. Understanding the biology of triple-negative breast cancers will help to develop less toxic therapeutic strategies.
Experiments performed in Gonzalo's laboratory, in collaboration with the laboratories of Xavier Matias-Guiu and Adriana Duso (IRBLleida, Spain), showed that activation of this novel pathway not only allows tumor cells to grow unchecked, but also explains the reduced sensitivity of these types of tumors to current therapeutic strategies. Importantly, vitamin D plays a role in turning off this pathway, providing a safe and cost-effective strategy to fight these types of tumors.
For molecular biologists like Gonzalo who look for answers below the cellular level to discover why some people develop cancer, the search often involves tracing a chain of events to try to understand cause and effect of the behavior between several genes and the proteins which they express. In order to understand these complex pathways, researchers often turn levels of proteins on or off by expressing one gene or suppressing another. Part of a researcher's challenge is determining what the function of each component of a pathway is.
The cell employs a complex mechanism to protect genetic information and ensure that damaged DNA is not passed on to daughter cells. Cells have built in checkpoints and fail safes to ensure the accuracy of their DNA code and are able to slow or stop their own proliferation if the information is compromised. Loss of these checkpoints and the accumulation of damaged DNA often leads to cancer.
BRCA1 is a well-established tumor suppressor gene. Women who carry mutations in this gene have a high risk of developing breast and ovarian cancer. Tumors that arise often lack expression of three receptors: estrogen, progesterone and HER2 (thus, "triple-negative"), and do not respond to hormone therapy.
BRCA1 is important because it is involved in repairing DNA double-strand breaks, a kind of DNA damage that is especially dangerous for the integrity of our genome. BRCA1 also is involved in cell-cycle checkpoints after damage, which are control mechanisms during cell proliferation that make sure the DNA information has been accurately replicated and transferred to the daughter cells. Thus, BRCA1 is considered a safeguard of the genome.
Loss of BRCA1 is bad news for the information contained in a cell's genetic blueprint. It results in genomic instability characterized by unrepaired DNA breaks and chromosomal aberrations that compromise cell viability. How BRCA1-mutated cells are able to form tumors has been a long-standing question. Investigators recently showed that loss of another DNA repair factor, 53BP1, allows proliferation and survival of BRCA1-deficient cells. In addition, decreased levels of 53BP1 were observed in triple-negative breast cancers, and correlated with resistance to drugs at the forefront of cancer treatment, such as PARP inhibitors.
Gonzalo's team has found a pathway responsible for the loss of 53BP1 in breast cancers with poor prognosis, specifically BRCA1 mutated and triple-negative. It turns out that loss of BRCA1 increases the expression of a protease, known as cathepsin L (CTSL), which causes the degradation of 53BP1. Cells that have lost both BRCA1 and 53BP1 have the ability to repair DNA, maintain the integrity of the genome, and proliferate. Thus, the protease helps cells with faulty BRCA1 to survive.
If lowering the levels of 53BP1 allows BRCA1 deficient cells to thrive and do their worst, increasing the levels of the protein offers a promising strategy for treatment of breast tumors.
So, how to do this? In previous research, Gonzalo's team showed that vitamin D inhibits CTSL-mediated degradation of 53BP1 in non-tumor cells, as efficiently as specific CTSL inhibitors. This time, they found that treatment of BRCA1-deficient tumor cells with vitamin D restores high levels of 53BP1, which results in increased genomic instability and reduced proliferation.
Importantly, their evidence suggests that vitamin D treatment might restore the sensitivity to PARP inhibitors in patients who become resistant. Thus, a combination of vitamin D and PARP inhibitors could represent a novel therapeutic strategy for breast cancers with poor prognosis.
So, with this chain of events, Gonzalo and colleagues demonstrated a pathway by which triple-negative breast cancers proliferate: BRCA1-deficient cells activate CTSL which minimizes levels of 53BP1 to overcome genomic instability and growth arrest.
In a final exceptionally useful discovery, Gonzalo and collaborators found that high levels of nuclear CTSL and low levels of 53BP1 and nuclear vitamin D receptor (VDR) are a clear marker that identifies certain triple-negative breast cancer patients, biomarkers that offer the potential to customize future breast cancer therapies. In particular, this triple-biomarker signature will allow the identification of patients in whom the pathway is on and who might benefit the most from vitamin D treatment.


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Kevin Harvick: He's atop the NASCAR standings, he's got three tour wins. So is he the man to beat for the title? (Photo: Getty Images for NASCAR)
By Mike Mulhern
"I am curious to see how we can perform."
Kyle Busch too has fallen a bit in performance.
Kurt Busch has come on strong finally.
Denny Hamlin has been off more than on. Same with Jimmie 'Five-time' Johnson.
Kevin Harvick is new man atop the NASCAR standings, and he's got three wins. But……
Why suddenly no seemingly dominant driver on the tour?
"That is a very good question," Jeff Gordon says. "When the season started, I thought Carl had the ability to put that together, or another Roush (Ford) driver. They seemed to be the strongest.
"But some of the teams that were behind have caught up. I don't know if they (Edwards and Roush teammates) have progressed as much as other teams; they had an edge on us when the season started.
"Kevin Harvick has been very strong…but his performance has not been up to maybe what I thought it could be, though he does have three wins.
"Then you have Jimmie Johnson and Denny Hamlin, who have been off to a little bit of a slow start.
"The cool thing is there is no clear-cut favorite right now."
Jeff Gordon: Game face. (Photo: Getty Images for NASCAR)
Kyle Busch, Johnson, Gordon, Paul Menard and Edwards all appear to have a leg up on their rivals here at the moment, after a long, hot Thursday of testing, with data-acquisition computer packages on the cars.
But Friday, amid some drizzling rain, drivers switch to their Kentucky 400 primaries to see if everything those high-tech engineers figured out Thursday night back at the motels really works. And the incessant showers kept teams bottled up.
Despite NASCAR racing Nationwide and Trucks here for some 10 years, and several years of using this 1-1/2-mile track for intensive testing, no one here so far seems very confident about what to expect in Saturday night's 400 (7:45 pm ET).
Kyle Busch opened the longer than usual week with a hard-fought win in Thursday's Truck race, after starting last.
"This place, you never get a comfort here at Kentucky," Busch says. "It's such a hard race track.
"Turn three is my Achilles Heel; it's killing me."
Others point to very bumpy turn one as perhaps the toughest part of the track.
"This place is rough," Kurt Busch says. "Hey, Bruton, where's the repave? But the character in the track is fun and different…and maybe it will let us rough each other up, and put some donuts on these cars."
The repave is coming, before next summer's race here. And more repaves are coming at Phoenix and Kansas and maybe Watkins Glen, in a surprisingly flurry of asphalt moving.
Kyle Busch: opened the weekend winning Thursday night's Truck race (Photo: Getty Images for NASCAR)
Edwards started the season as the hottest driver and has been a contender in nearly every race. However those 37ths at Pocono and Daytona may be taking some steam out of his sails.
And there is the increasingly nagging feeling that something may not be going just right in those contract renegotiations with team owner Jack Roush.
Edwards himself has become remarkably uncontroversial this season, almost Jimmie Johnson 'plain vanilla,' in an odd move. His interviews are smooth and polished, but almost too smooth and polished.
But then this is a potential championship season and no point in ticking anyone off unnecessarily.
But then out on the track Edwards has shown a good blend of ferocity and cool patience. And he could easily have four or five wins now.
However Edwards has but one victory.
Indeed at the midpoint of the season it is rather surprising that there have been 11 different winners in the 17 races. At that pace more than 20 men could win this year. The benchmark for season winners lately was the 2001 season, with 19 men winning.
Whatever edge Edwards hoped to have here, from his Nationwide runs, has seemingly vanished.
"The Nationwide cars drive so much differently," he says. "The Cup cars, you are off the throttle, the front end of the car is loaded longer in the corner, and the bumps feel different…the way you apply the throttle is different.
"I haven't driven a Cup car here for a long time…since we tested in like 2004. Driving down in these corners, they are very treacherous; they don't look like it, but they are. Especially turn three -- It is very flat and deceivingly slippery.
"I wouldn't call it a bumpy track -- I would say it is a track that has a lot of character….the bumps are part of it.
"You could chase a guy down, pressure him, get him to go through the bumps the wrong way and slide up the race track. You can make moves.
"The last Nationwide race (here) I worked on Joey Logano for laps down there (turn one), and I couldn't figure out a way to get around him. I had all sorts of options, but I couldn't get him."
Dale Earnhardt Jr. (L) and crew chief Steve Letarte: It would be nice if this sport's most popular driver could make a run at the championship (Photo: Getty Images for NASCAR)
Saturday night, to hear these drivers talk, expect a lot of cautions, in turns one and three.
"Kyle is right: Those bumps will make things interesting," Edwards says. "If you dive down there under someone, the guy on the outside might want to take that into account, that the car might not stick as well on the bottom as a guy wants to.
"Turn three isn't based on bumps but has the same feeling, because the car can slide sideways there.
"I don't think a guy will sit in the lead and run away with it. I think someone will be able to make something happen."
And if that someone is Edwards, he says he'll try to make his post-victory charge right to the top of the grandstands.
Robby Gordon is skipping Saturday night's Kentucky 400 and flying to Las Vegas for Sunday's launch of the week-long 'Bullrun,' in a specially prepared Chrysler Jeep. The finish line is Miami.
"It's basically a modern day Cannonball Run, just set up like the Dakar Rally (with checkpoints),' Gordon says. "It's run on public highways within speed limits….but the guy that gets there first still wins."
The day's route isn't released until that morning.
At Daytona Carl Edwards was stunned at the heat generated inside his car after he damaged the 'crush panels' near the rear wheel when he slapped the wall early.
"Whatever was going on back there it was pumping the exhaust fumes directly into the car.
"That is the hottest I have ever been in my life by a big margin.
"Once they put the crush panel back in, it was good.
"I don't think the car or driver could make it for more than 30 minutes or something like that. I think things would be on fire.
"It opened my eyes to how hot things can be in those cars if you knock those crush panels out.
"I don't know how many races I have run in, but I have never had that situation before. Not anything like it.
"If the hottest I had ever been before was say, 140 degrees, it felt like it was 240 degrees.
"It was a whole different dimension of heat. It got my attention.
"The guys were mad at me I didn't pull in and fix it right away. But you can't pull in and say 'Hey, I am too hot.'
"But I was doing the math -- we had 100-and-something laps to go, and I'm thinking 'I don't know if this is going to work.'"
The late Daytona pit stops that teammates Jimmie Johnson and Dale Earnhardt Jr. made – out of sequence with each other – wound up separating them and possibly costing both a shot at the win. And Johnson and crew chief Chad Knaus took some heat for it, for seemingly taking Earnhardt out of the hunt.
Earnhardt says the dust-up is overblown.
"They made the decision to do one thing and we did another," Earnhardt says. "It didn't really bother me at all.
"I figured Jimmie would still have a good opportunity to get up to me and help us. And we pretty much were in fine shape until people forgot how to drive -- or people thought they could disobey the laws of physics.
"You run all night long to get to the end of that race, and you can see the finish line…and you just crash for some reason. It's pretty stupid.
"If they want to come pit, they've got to come pit. I can't argue with that. I'm fine with that. I don't have a problem with what he did. No big deal. The caution was out; good time to go down pit road."
But the fan response…..
"These people are passionate," Earnhardt says. "They get it in their minds what they think is right and what they think happened and they run with it.
"People have strong opinions.
"I heard about how they beat on Jimmie a little bit on his Twitter page. And I called him up and said 'Now you know why I don't have Twitter. I'd be getting it every week.'"
Johnson says he was intrigued with the Twitter War: "I was really impressed and appreciate the support from Junior Nation...and then also my fan base defending me. It was my first real experience to how active social media can be following a race."
What part of a sagging economy do some of these so called Racing experts not understand? There R so many race fans out of work and they have had to cut back on so many thing in there lives just to try and stay a float. Then these Race Bloggers and Analyst rip the fact that attendance is down TV rating are down, how about taking this in to consideration; 1 People have had to cut out Cable TV, 2 people can't afford to travel and buy tickets for live event right now, that doesn't mean they are not race fans anymore, 3 there is not a sport out there that has a loyalty factor like Motorsports Fans, 4 Spend the amount of monies to still make their family Vacation a trip to a Race weekend, 5 MLB,NBA,NFL they all have had slow downs in Attendance's, Collectable Sales, but no slow down in seeing those over paid so called HERO'S going to jail for every despicable and degenerate type of action that your common street thug carry's out everyday, 5 compare our sports integrity and benevolent efforts up against any other and you will see we come out by far on top. So in closing Stop complaining about stuff that is really not a factor in the sport declining it isn't the Economy Decline not our Fans. Motorsports is alive and well taking in to consideration the fate of our ECONOMY. Or Mike don't you agree???
i agree the economy isn't helping things here. which is why i dont like the idea of nascar being relegated to cable, rather than network; i still struggle to find speed on the road....
and travel expenses are horrendous, for everyone.
which is one reason i'm not convinced this sport needs to be telling owners to spend extra money on corn fuel and expensive gas cans and electronic fuel injection, and other gimmicks that dont add to the show but just drive up expenses. when the sport gets so expensive that sponsors start bailing out, we're all in trouble.
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(Poem #1039) Prayer before Birth
I am not yet born; O hear me. Let not the bloodsucking bat or the rat or the stoat or the club-footed ghoul come near me. I am not yet born, console me. I fear that the human race may with tall walls wall me, with strong drugs dope me, with wise lies lure me, on black racks rack me, in blood-baths roll me. I am not yet born; provide me With water to dandle me, grass to grow for me, trees to talk to me, sky to sing to me, birds and a white light in the back of my mind to guide me. I am not yet born; forgive me For the sins that in me the world shall commit, my words when they speak to me, my thoughts when they think me, my treason engendered by traitors beyond me, my life when they murder by means of my hands, my death when they live me. I am not yet born; rehearse me In the parts I must play and the cues I must take when old men lecture me, bureaucrats hector me, mountains frown at me, lovers laugh at me, the white waves call me to folly and the desert calls me to doom and the beggar refuses my gift and my children curse me. I am not yet born; O hear me, Let not the man who is beast or who thinks he is God come near me. I am not yet born; O fill me With strength against those who would freeze my humanity, would dragoon me into a lethal automaton, would make me a cog in a machine, a thing with one face, a thing, and against all those who would dissipate my entirety, would blow me like thistledown hither and thither or hither and thither like water held in the hands would spill me. Let them not make me a stone and let them not spill me. Otherwise kill me.
I love the headlong momentum of this poem. MacNeice's poetry is usually delicately balanced, informed by a world of possibility (and uncertainty). Not so "Prayer before Birth", in which phrase piles on phrase in a desperate catalogue of the perils of contemporary life. The cascading lines, heavy in their use of internal rhymes and repetitions, assonances and alliteration, are insistent, driving, a crazed litany; they're powerful, yet wonderfully poignant. The unborn child speaking this dramatic monologue could be any of us. thomas. [Minstrels Links] Louis MacNeice: Poem #18, Bagpipe Music Poem #521, The Suicide Poem #757, The Sunlight on the Garden Poem #864, Snow Various prayers: Poem #177, Where The Mind is Without Fear -- Rabindranath Tagore Poem #344, The Navajo Night Way Ceremony -- Anon. (Navajo) Poem #349, A Prayer to the Sun -- Geoffrey Hill Poem #987, Prayer -- Carol Ann Duffy Poem #1007, Abide With Me -- Henry F. Lyte Poem #1020, A Prayer for My Daughter -- William Butler Yeats Poem #1029, Prayer (to the sun above the clouds) -- Piet Hein [Somewhat Technical Afterthought] "Prayer before Birth" may look like free verse, but it's actually carefully structured. Apart from the devices mentioned above, note the extensive use of dactyls (metrical feet of one stressed and two unstressed syllables), which contribute to the cadence of the poem: my thoughts when they think me - / - - / - my treason engendered by traitors beyond me, - / - - / - - / - - / - my life when they murder by means of my hands, - / - - / - - / - - / The poet also uses the occasional spondee (two consecutive stresses) to prevent the rhythm from becoming monotonous: I fear that the human race may with tall walls wall me, - / - - / - / - - / / / - with strong drugs dope me, with wise lies lure me, - / / / - - / / / - on black racks rack me, in blood-baths roll me. - / / / - - / / / -