text:
All-new version delivers passion in a big sedan.
Fullsize Cars
Editor: Paul A. Eisenstein
$30,990 Base Price MSRP
$40,445 As Tested MSRP
Model Lineup: "Toyota Avalon XLE ($30,990), XLE Premium ($33,195), XLE Touring ($35,500), Limited ($39,650); Avalon XLE Hybrid ($35,555), XLE Touring Hybrid ($37,250), XLE Limited Hybrid ($41,400)"
Standard Engine: 3.5-liter V6
Engine Options: 268-hp 3.5-liter V6; 200-hp 2.5-liter I4 paired with twin motor/electric generator system
Standard Transmission: 6-speed automatic
Transmission Options: 6-speed automatic (V6 models); Synergy Hybrid Drive CVT with planetary gears (Hybrid models)
Basic Warranty: "3-year/36,000-mile"
Assembled In: "Georgetown, Kentucky"
Model Tested MSRP: "Toyota Avalon Limited ($39,650)"
Standard Equipment: "leather-trimmed perforated multi-stage heated and ventilated front seats; 10-way power driver's seat, 8-way front passenger's seat; driver's seat memory; three-zone climate control with air filters; Intelli-touch climate controls for HVAC system; Premium HDD Navigation with EnTune; Backup Camera; Cruise Control; premium leather tilt/telescope steering wheels with controls for cruise and Bluetooth; heated rear seats; fold-down rear seats; wood grain-style interior trim; white ice interior ambient lighting; Smart Key system; power door locks; power windows; power rear window sunshade; auto-dimming rearview mirror with compass, maplinks and Homelink transmitter; eBin sliding electronic device holder with dual power outlets; rain-sensing wipers; acoustic windshield; dual chrome exhaust tips; aluminum door sills; HID headlamps; foglamps; LED taillights; color-keyed auto-dimming outer mirrors; power tilt/slide moonroof; 18-inch alloy wheels"
Options As Tested: none
Standard Safety Equipment: "Star Safety System, 10 airbags, whiplash-injury lessening seats, LATCH child seat system, tire-pressure monitor"
Optional Safety Equipment: "Safety Connect, Pre-Collision System, Blind Spot Monitor with Rear Cross Traffic Alert"Destination Charge: $795
For a brand long known for its high quality and plain vanilla design, Toyota sent shock waves through the industry when it first displayed the all-new Avalon. When compared to the latest-generation Camry midsize sedan, the 2013 Avalon full-size sedan looks like it came from another company entirely. But the 2013 Avalon is precisely what Toyota's top executive, President Akio Toyoda, the grandson of the company's founder, had in mind when he promised to pump new passion into the brand.
The 2013 Avalon is visually striking, with the sort of cutting-edge styling you might expect from the latest Ford or Hyundai, or even Mercedes-Benz. The new design clearly gives the new Toyota a much more expensive look and feel.
The overall look of the 2013 Toyota Avalon is more muscular and refined than the old, lumpen box, with a coupe-like roofline that is somewhat reminiscent of the striking Audi A7. The interior, meanwhile, boasts an almost luxury-class level of refinement, with upgraded leather that is now being hand-stitched to deliver a visual sense of craftsmanship. The large touchscreen adapts the latest version of Toyota's EnTune infotainment system and the LCD screen atop the center stack replaces most traditional knobs and buttons. The rest migrate to a capacitive system that can be operated with barely a touch.
The redesigned 2013 Avalon is available with two distinct powertrain options, the most popular of which is likely to be the 3.5-liter, 90-degree, DOHC, six-cylinder engine with Variable Valve Timing with Intelligence that produces 268 horsepower at 6200 rpm and 248 pound-feet of torque. The 3.5-liter V6 delivers surprisingly good fuel economy considering the size of the new Avalon sedan and the power it pumps out. We found it smooth and powerful. Toyota says the Avalon with the 3.5-liter V6 can accelerate from 0 to 60 mph in 6.7 seconds, which is quite quick.
Those who want to maximize mileage will be drawn to the Avalon hybrid models, which use the latest iteration of the Toyota Hybrid Synergy Drive and are expected to get up to 40 miles per gallon. That's impressive for a full-size sedan, and all the more impressive considering the minimal sacrifice in performance. The 2013 Toyota Avalon Hybrid is estimated to launch from 0 to 60 mph in around 8 seconds, which is average acceleration performance. The 2013 Avalon is the first full-size Toyota sedan to offer a hybrid gas-electric powertrain.
The 2013 Toyota Avalon is produced at Toyota's plant in Georgetown, Kentucky. The new Toyota sedan is, in fact, the most American car the Japanese maker has ever offered, the design work being handled by Toyota's advanced styling studio in Southern California, while the primary engineering work was done in suburban Detroit."
"The 2013 Toyota Avalon comes in XLE and Limited grades and several sub-trim levels. Avalon XLE ($30,990) comes standard with heated, leather front seats, eight-way power driver's seat, four-way power front-passenger seat, 6.1-inch touch-screen display, two-door Smart Key, heated mirrors, mirror turn signals, 17-inch alloy wheels. Avalon XLE Premium ($33,195) adds a rearview camera and moonroof, three-door Smart Key, auto-dimming mirror with compass, garage door opener, three-button Eco Switch. Avalon XLE Touring ($35,500) includes fog lamps, 18-inch alloy wheels, blind-spot monitor with rear cross-traffic alert, navigation system, paddle shifters and EnTune Display Audio.
Avalon Limited ($39,650) upgrades further with premium perforated leather heated and cooled front seats, 10-way power driver's seat, eight-way power front-passenger seat, heated rear seats, three-zone climate control, 7-inch high-resolution touch-screen audio, with navigation, Entune and JBL, JBL Premium HDD audio, color HVAC screen, Safety Connect, rain-sensing wipers, rear sunshade, HID headlamps, LED Daytime Running Lights, puddle lamps, ambient lighting, auto-dimming outside mirrors.
Avalon Hybrid XLE Premium ($35,555), Avalon Hybrid XLE Touring ($37,250), and Avalon Limited ($41,400) are similarly equipped. (All prices are Manufacturer's Suggested Retail Prices and do not include $795 destination charge.)
The optional Technology Package ($1,750) for Avalon Limited and Hybrid models adds Dynamic Radar Cruise Control, automatic high beams, and Pre-Collision System.
Safety features standard on all Avalon models include Toyota's Star Safety System, 10 airbags, whiplash-lessening seats, three-point seatbelts, LATCH child-seat anchors, child-protector door locks, anti-theft system with alarm and engine immobilizer. Optional safety features include Safety Connect, Pre-Collision System, Blind Spot Monitor with Rear Cross Traffic Alert."
Walk Around
"The 2013 Toyota Avalon has a wider, more aggressive stance than the outgoing sedan, there's a sense of kinetic energy that we can't ever recall seeing in a Toyota sedan especially one this big. The overall feel is one of a slightly more compact and taut vehicle, perhaps reflecting the fact that its overall height has been lowered an inch, with the overhangs shortened 0.6 inches up front and 1.8 inches in the rear.
Nowhere is the new look more obvious than up front, where the Avalon's new face bears more than a subtle similarity to the latest-generation Ford Fusion, itself strongly influenced by ultra-luxury sports car maker Aston Martin. That Ford/Aston trapezoid grille is framed, at top by wraparound Quadrabeam projector headlamps, below by distinctive new foglamps.
This is the fourth generation of the Avalon. The soft, almost flabby look of the outgoing model (pre-2013) has been replaced by a tautly sculpted body, character lines stretching through the hood and from just behind the front wheels to the tips of the taillights. Toyota designers worked in half-windows at the back of the sloping roof to give rear seat passengers and even broader view of the world passing by. That underscores the way Toyota has attempted to make form and function equal partners in the new Avalon."
"With some coupe-like sedans, there's a distinct trade-off in functionality, but the 2013 Avalon's 111-inch wheelbase allowed designers to sculpt a curvaceous exterior and still provide a surprising amount of head, leg, hip and elbow room, front and back. Headroom in the front seats is 38.5 inches, or 37.6 inches with the optional moonroof.
And there's little excuse for rear seat passengers not to stretch out and relax.
Front and back, the 2013 Toyota Avalon is a far more lavishly outfitted sedan than the model it replaces. With one notable exception, Toyota has largely abandoned the cheap plastic panels that have drawn criticism in other recent models, including the latest generation of the Camry.
We're tempted to describe the layout from the pilot's perspective as almost cockpit-like. Toyota designers and engineers have worked well together to bring all that the driver might need to see or touch into just the right position, including that large touchscreen used for the EnTune infotainment system. As you'd expect, it is the anchor of basic systems like navigation, audio and Bluetooth calling. It also allows ready access to smartphone-based apps such as Pandora, Bing, iHeartRadio, and services like fuel pricing, stock reports, traffic and weather data. Meanwhile, a second, capacitive-touch screen operating the climate control system. But you don't have to mess with all that. The navigation system is optional and can be avoided altogether. If you don't opt for navigation, the screen remains, for operating the radio and other features. Nighttime or daytime, the screen delivers a big, crisp image of what's behind you whenever you shift into Reverse.
The Avalon adopts the sort of elegant and subtle ambient lighting cues we've until recently expected only on mid to upper-range luxury vehicles. And that carefully stitched leather further adds to upscale feel. We think Toyota could have done a better job with the wood trim, however, which looks too much like plastic.
Cargo capacity is good: 16 cubic feet of trunk space, 14.4 cubic feet for Avalon Hybrid models. Folding down the back seats provides more cargo space and room for longer items."
Driving Impressions
"We got our first chance to drive the 2013 Avalon in its various configurations during an advanced drive at Toyota's suburban Detroit test track. The experience revealed the new Avalon to be a significant improvement from the soft and mushy boulevard cruiser that defined prior generations of the Avalon.
Toyota took significant steps to firm things up. Among them: more braces and welds to increase chassis rigidity. A rigid chassis is a key element both for sharp handling response and a smooth ride. This allowed more precise tuning of the suspension. Suspension changes include new stabilizer bars and new spring rates. Toyota used MacPherson struts up front and a multi-link suspension in the rear. Shedding about 100 pounds of mass also helped.
Body roll (lean) has been largely kept under control. Meanwhile, there's virtually no torque steer on this front-driver, even under the most aggressive launches. Torque steer is the tendency of the front wheels to turn under hard acceleration, felt as a tug on the steering wheel; stand on the accelerator, and the new Avalon takes off in a straight line.
The electric power-assisted steering system errs towards a little too much boost, though it tightens up, if artificially, in Sport mode. One disappointment was the decision not to allow the driver to further stiffen the suspension when shifting into Sport mode on the Touring and Limited grades. The electronic system only modifies throttle, steering and gear shifts to improve overall responsiveness. We'd have liked to add still more tautness to the suspension, as well. But kudos for adding Dynamic Rev Management, which is particularly useful with paddle-shift-equipped models (Touring and Limited editions).
At 268 horsepower, the 3.5-liter V6 provides more than adequate, if not neck-snapping, power. It's mated to a 6-speed automatic. That's a couple gears short of other full-size offerings but we doubt many will notice considering that shifts are almost completely transparent and there's little sense of hunting even aggressive driving.
At an EPA-estimated 21/31 mpg City/Highway, or 25 mpg Combined, the 2013 Toyota Avalon provides a significant improvement for what you might have imagined getting from a full-side sedan just a few years ago. Regular 87-octane gasoline is recommended, no Premium fuel required here.
Even more impressive is the first-ever Avalon Hybrid, rated at 40 mpg City, 39 mpg Highway and 40 mpg Combined. Those are numbers you might have longed for with a subcompact when the last-generation Avalon hit market.
The Avalon Hybrid package teams a four-cylinder engine with a pair of electric motors using essentially the same Toyota Synergy Hybrid drive found in the latest version of the Camry. It's about a second-and-a-half slower than the V6 Avalon from 0-60 mph but it still delivers enough power to feel confident passing or getting onto a freeway.
Avalon Hybrid's 2.5-liter inline-4, for the technically minded, uses the fuel-saving Atkinson Cycle and itself develops 156 horsepower and 156 pound-feet of torque. The electric motor brings that up to an even 200 hp. Toyota claims the Avalon can operate on battery power alone. But this is no plug-in. You'll be lucky to get a full mile if the battery is fully charged. While the Avalon Hybrid can technically operate in electric mode at speeds up to 25 mph, that's rare. It'll usually fire the four-cylinder engine up well before then, especially if you've got a heavy throttle foot. A neat trick with the Hybrid is the ability to maintain climate control even when the gas engine is shut off."
"The all-new Toyota Avalon brings fresh design in an easy to operate large sedan. The new Avalon XLE adds some desirable new features at a discount of several thousand dollars over the previous version. Handling is much improved for a taut feel, while excellent ride quality is maintained. The standard 3.5-liter V6 is smooth and powerful, while a new hybrid-electric offers an EPA-estimated 40/39 mpg City/Highway. The new Avalon is an easy car to live with and an easy car to own.
Paul Eisenstein filed this NewCarTestDrive.com report after his test drive of the Avalon in Detroit."
Top Cars


text:
By Request
It's Here...
Earl HD (Harley Davidson) Edition
Runs on OS 5.0 Storm1 and Storm2.
Earl HD (Harley Davidson) Edition is a Hidden Today theme with a message underlay for ease of previewing current messages. Two sliding docks will show or hide just by touching the center of the bottom banner (HD logo). BerryWeather hotspot is left screen and Quick Launch hotspot is right screen. App Menu hotspot is lower left and Option Screen hotspot is lower right. Message tab will turn red as new messages arrive. There are 8 customizable icons. SSID added to bottom dock. Four tabs at the bottom are not customizable.
Runs on OS 5.0 Storm1 and Storm2
Storm1) 220.127.116.118 Compatible and above.
Storm2) 220.127.116.110 Compatible and above.
Featuring pop up message board.
To show or hide all icons touch the center of bottom dock where the logo is.
Click top right side for Quick Launch. (Quick Launch not included).
Click top left side for BerryWeather. (W/B not included).
Click the bottom left for App Screen.
Click the bottom right for Options screen.
Hidden clock at the bottom.
Manage connections at the bottom.
Custom lock screen.
Custom icons.
Custom menu highlights.
New mail notification indicator on the static message button.
Eight customizable icons.
Please check out my screenshots above.
Tested on Storm1 OS .328 and Storm2.

subset: commoncrawl


text:
Greetings, and Dear Cynthia,
I'm a bit behind in lots of things, but thought I'd share some photos of the Halloween costumes I made for the boys about two months ago - at some point I promised photos, and I try to be a woman of my word... Here is a dolphin:
Here is a triceratops:
People had to ask what the triceratops was -- apparently it was not *evident* just by looking at him... I guess that can happen when you are starting with a penguin pattern and making it up as you go...
I bound off my "Asymmetric Cardi" more than a month ago, and I hated it. It was supposed to look sorta like this...
...except in a lovely Red Wine colorway.
Here is what it actually looked like. Please ignore the fact that I am wearing house pants in these photos:
It's difficult to discern from these photos, but the fit through the shoulders was really poor, I didn't like the neckband/collar area AT ALL, I would never be able to wear it unbuttoned because it hung sorta funny all asymmetric and all, and I did not like the way the buttonholes were done because they and the entire front edges were really quite sloppy looking...
I tried a re-design on the fly, and I'll spare you the details, but it was becoming a sweater that I was NOT GOING TO LOVE, and so I ended up completely ripping it out...and now I am much happier... The yarn is still nice even though I am knitting it into a sweater FOR THE THIRD TIME...but I now bring you Twist from Chic Knits:
LOVE IT SO FAR! I was going to knit the pattern verbatim, but apparently I have some sort of defect and can't do that -- OVERALL I'm not changing it. I'm knitting the back and fronts all at the same time (to avoid side seams, to make sure all of the decreases/increases for the waist shaping occur symmetrically, etc.). I love the cables!
I hope you have a Happy New Year! Any knitting goals for the new year? I am resolving to attend Stitches Midwest next August ;-)
Warm regards,
Laura (YarnThrower)


text:
B.A (Wave King) - Tell Me [Label Submitted]
For serious inquiries only contact
download B.A Bad azz mixtape on datpiff.com
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text:
Flowers for Cuba, Cultivo, rosa, blanca, cortada, flower, power
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text:
Acrylic Cable Knit Bobble Hat
Baby Blue
Our luxury acrylic bobble hat featuring a detachable bobble crafted from real-look faux fur, completed with a staple Holland Cooper engraved disc to bring a touch of prestige to every outfit.
A must-have addition to every Autumn/Winter wardrobe, our luxurious acrylic cable knit bobble hat features a detachable real-look faux fur bobble, finished with a Holland Cooper engraved disc to add a touch of prestige to every outfit.
Exuding style and practicality, our acrylic cable knit bobble hats provide comfort and warmth during the colder months, perfect if you're hitting the slopes or walking the dogs. Add a touch of chic to your look with this one-size luxury bobble hat.
Shell: 100% Acrylic
Bobble: 100% Acrylic
(Please not that this is one of the few HC items that is not entirely made in the UK).
Bobble hat shell machine washable. Remove bobble before wash.
Find out the shipping options available for your destination.View
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Our consultants are available between Monday - Friday: 9am - 5pmContact
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text:
The flight of Vostok 1
On the morning of 12 April 1961, at 5:30 a.m. Moscow time (2:30 UTC), cosmonauts Yuri Gagarin and his back-up Gherman Titov were woken in their hut at the Baikonur Cosmodrome. They had breakfast, were assisted into their spacesuits, and then were transported to the launch pad. Gagarin entered the Vostok 1 spacecraft and at 07:10 local time, the radio communication system was turned on.
The hatch of the spacecraft was closed about 40 minutes later, but it was soon discovered that the seal was not complete, so technicians spent nearly an hour removing all the screws and then resealing the hatch.
During this time, Gagarin requested some music to be played over the radio. Chief designer Sergei Korolev was very nervous in the control centre, but Gagarin was described as 'calm'; about half an hour before launch his pulse was recorded at 64 beats per minute.
Launch occurs from the Baikonur Cosmodrome Site No.1. Korolev radioed, "Preliminary stage..... intermediate..... main..... LIFT OFF! We wish you a good flight. Everything is all right." Gagarin replied, "Poyekhali! (Off we go!)."
06:09 UTC (T+ 119 s)
Two minutes into the flight and the four strap-on booster sections of the Vostok rocket have used up the last of their propellant, they shut down and drop away from the core vehicle.
06:10 UTC (T+ 156 s)
The payload shroud covering Vostok 1 is released, this uncovers the window at Gagarin's feet with the optical orientation device Vzor.
06:12 UTC (T+ 300 s)
Five minutes into the flight and the Vostok rocket core stage has used up its propellant, shuts down and falls away from the Vostok 1 spacecraft and final rocket stage. The final rocket stage ignites to continue the journey to orbit.
The rocket is still firing, pushing Vostok 1 toward orbit. Gagarin reports, "...the flight is continuing well. I can see the Earth. The visibility is good. I almost see everything. There's a certain amount of space under cumulus cloud cover. I continue the flight, everything is good."
The rocket continues to fire, starting to pass over central Russia now. Gagarin reports, "Everything is working very well. All systems are working. Let's keep going!"
Three minutes into the burn of the final rocket stage and Gagarin reports, "Zarya-1, Zarya-1, I can't hear you very well. I feel fine. I'm in good spirits. I'm continuing the flight..." Vostok 1 is moving further downrange from the Baikonur Cosmodrome. He is reporting back to Zarya-1 (the Baikonur ground station) and must be starting to move out of radio range of that station.
Orbital flight
The Vostok rocket final stage shuts down, ten seconds later the spacecraft separates and Vostok 1 reaches orbit. (T+ 676 s) Gagarin reports, "The craft is operating normally. I can see Earth in the view port of the Vzor. Everything is proceeding as planned". Vostok 1 passes over Soviet Union and moves on over Siberia.
Vostok 1 passes over the Kamchatka peninsula and out over the North Pacific Ocean. Gagarin calls, "...the lights are on on the descent mode monitor. I'm feeling fine, and I'm in good spirits. Cockpit parameters: pressure 1; humidity 65; temperature 20; pressure in the compartment 1; first automatic 155; second automatic 155; pressure in the retro-rocket system 320 atmospheres..."
As Vostok 1 begins its diagonal crossing of the Pacific Ocean from Kamchatka peninsula to the southern tip of South America, Gagarin asks, "What can you tell me about the flight? What can you tell me?" He is requesting information about his orbital parameters. The ground station at Khabarovsk reports back, "There are no instructions from No. 20 (Sergei Korolev), and the flight is proceeding normally." They are telling Gagarin that they don't have his orbital parameters yet because the spacecraft has been in orbit for only six minutes, but the spacecraft systems are performing well.
Gagarin transmits to the Khabarovsk ground station, "I feel splendid, very well, very well, very well. Give me some results on the flight!". Vostok 1 is nearing the VHF radio horizon for Khabarovsk and they respond, "Repeat. I can't hear you very well". Gagarin transmits again, "I feel very good. Give me your data on the flight!" Vostok 1 passes out of VHF range of the Khabarovsk ground station and contact is lost.
Vostok 1 continues on its journey as the Sun sets over the North Pacific. Gagarin crosses into night, northwest of the Hawaiian Islands. Out of VHF range with ground stations, communications must now take place via HF radio.
Khabarovsk ground station sends the message "KK" via telegraph (on HF radio to Vostok 1). This message means, "Report the monitoring of commands." They were asking Gagarin to report when the spacecraft automated descent system had received its instructions from the ground control. Gagarin reported back at 06:48 UTC.
Vostok 1 crosses the equator at about 170° West, traveling in a south east direction and begins crossing the South Pacific. Gagarin transmits over HF radio, "I am transmitting the regular report message: 9 hours 48 minutes (Moscow Time), the flight is proceeding successfully. Spusk-1 is operating normally. The mobile index of the descent mode monitor is moving. Pressure in the cockpit is 1; humidity 65; temperature 20; pressure in the compartment 1.2 ... Manual 150; First automatic 155; second automatic 155; retro rocket system tanks 320 atmospheres. I feel fine..."
Gagarin reports he is on the night side of Earth.
Gagarin reports the Sun-seeking attitude control system had been switched on. The Sun-seeking attitude control system is used to orient Vostok 1 for retrofire. The automated orientation system consisted of two redundant systems: an automatic/solar orientation system and a manual/visual orientation system. Either system could operate the two redundant cold nitrogen gas thruster systems, each with 10 kg (22 lb) of gas.
The Khabarovsk ground station sends Gagarin the following message via HF radio, "By order of No.33 (General Nikolai Kamanin) the transmitters have been switched on, and we are transmitting this: the flight is proceeding as planned and the orbit is as calculated." They are telling Gagarin that Vostok 1 is in a stable orbit. He acknowledges the message.
Vostok 1 is over the South Pacific between New Zealand and Chile when Gagarin sends this message, "...I'm continuing the flight, and I'm over America. I transmitted the telegraph signal 'ON'.
Vostok 1 crosses the Strait of Magellan at the tip of South America. News of the Vostok 1 mission is broadcast on Radio Moscow.
Gagarin sends spacecraft status message, similar to the one sent at 06:48. The message is not received by ground stations.
Gagarin sends spacecraft status message, the message is not received by ground stations.
Passing over the South Atlantic, the Sun rises and Vostok 1 is in daylight again. Vostok 1 is 15 minutes from retrofire.
Gagarin sends spacecraft status message, similar to the one sent at 06:48. Moscow picks up this partial message from Gagarin, "I read you well. The flight is going..."
Gagarin sends spacecraft status message, the message is not received by ground stations.
Gagarin sends spacecraft status message, the message is not received by ground stations.
The automatic system brings Vostok 1 into alignment for retrofire about one hour into the flight.
Reentry and landing
The spacecraft's automatic systems bring it into the required attitude (orientation) for the reentry engine firing, and shortly afterwards, the engine firing occurs. This takes place over the west coast of Africa, near Angola, about 8000 km from the desired landing point. The liquid-fueled retrorockets fire for about 42 seconds.
Ten seconds after retrofire, commands aree sent to separate the Vostok service module from the reentry module, but the Vostok equipment module unexpectedly remains attached to the reentry module by a bundle of wires.
Around 07:35 UTC
The two halves of the spacecraft begin reentry and go through strong gyrations as Vostok 1 crosses over Egypt. At this point the wires break, the two modules separate, and the descent module settles into the proper reentry attitude. Gagarin telegraphs "Everything is OK" despite continuing gyrations. He later reports that he did not want to 'make a noise' because he had (correctly) reasoned that the gyrations did not pose a danger to the mission (and were apparently caused by the spherical shape of the reentry module).
As Gagarin continues his descent, he experiences about 8g during reentry but remains conscious.
Vostok 1 is still 7 km from the ground when the hatch of the spacecraft is released, and two seconds later Gagarin uses the ejection seat to leave the capsule. At 2.5 km altitude, the main parachute is deployed from the Vostok spacecraft.
Gagarin lands using his own parachute, which opened almost immediately after ejecting from the spacecraft ten minutes earlier. Both he and the spacecraft landed 26 km south west of Engels, in the Saratov region at 51° North, 45° East.
Two schoolgirls witness the Vostok 1 capsule landing and describe the scene: "It was a huge ball, about two or three metres high. It fell, then it bounced and then it fell again. There was a huge hole where it hit the first time."
A farmer and her daughter observe the strange scene of a figure in a bright orange suit with a large white helmet landing near them by parachute.
Gagarin later recalled, "When they saw me in my spacesuit and the parachute dragging alongside as I walked, they started to back away in fear. I told them, 'Don't be afraid, I am a Soviet like you, who has descended from space and I must find a telephone to call Moscow!'"


text:
If there is one thing the doctors told me from the get-go, the thing they let me know no matter how hard I pressed them for answers was this: No one knows how MS is going to affect any one person over another. The next page of my disease isn't written, let along the next chapter, so there is no way for anyone to read it.
Still we ask, ponder and wonder.
The truth, awful truth if you ask me, is that some people get clubbed by MS while others only receive the occasional switching. It hurts me deeply to see friends, dear people I've met since my diagnosis, slip faster and further than my disease course currently sails.
I had my time; I was forced to use a cane from diagnosis and it took 5 years before that piece of furniture became a less frequent accessory. My disease progressed so rapidly that we had to switch tactics and use (what was, at the time) the most aggressive treatment approved.
I'm better now.
I still have MS. I still have to alter my every day, hour, and minute sometimes. But my disease is, and has been for a while, on a stable and manageable plane.
This isn't the case for everyone…and I feel guilty.
There are some people in my MS community whom I only see once or twice each year; usually at large National MS Society events. To see the ambulatory become the immobile, the life of the party become labored in speech, the brightest of lights dimmed tears me apart.
Why is it that I am "making it" while others, no matter the strength of their resolve, are being pulled under? Why does MS take one friends legs, another's hands, another's speech while I can (with some time and assistance) walk my dogs and type this blog and soliloquize ad nauseum? How do they feel when they see me without my cane? Does it make their MS seem "worse" to them?
In my days as a Coast Guard navigator I took part in several rescues at sea, some of which not all survived. We were trained to rescue and transport survivors for further medical attention. We knew, however, that the physical was not the only disorder these survivors would have to battle. Survivor guilt is a real and terrible thing.
One ship experienced this first hand when one of my shipmates was killed in an accident at sea. Why me, or more accurately why not me, becomes an almost constant question for the survivors.
I think, and I'm not trying to diminish the effects of "real" survivor guilt in this post, that some of us – "the lucky ones" – may have to contend with our own survivor guilt.
How about you? Do you feel like you are one of those who are surviving? And from the other end, if you are more disabled by your MS, how does it make you feel when you see others of the brotherhood/sisterhood making their way through life without many limitations?
I hate what MS does and has done to my friends. I loathe MS for taking away from me what it already has taken. I fear what else this thief will abscond.
How about you?
Wishing you and your family the best of health.
Important: The views and opinions expressed in this article are those of the author and not Everyday Health.


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Capri Beach Club III Photo Canvas Print
Make 4 interest-free payments of $34.75 AUD fortnightly with More info
Featuring an array of blue beach chairs and umbrella on the shores of Capri Beach, this stretched photographic canvas art print arrives ready-to-hang on your wall and has a choice of several framing options.
All stretched canvases are designed and proudly made in Australia upon order, and come ready to hang as soon as you remove from the box. By selecting the first option, 'Stretched' this means that the woven canvas fabric is printed with our artwork, & then stretched to a wooden frame & will be ready to hang on your wall when shipped.
Or there is also an option to add a shadow box floating frame (four colour options available) for a more premium gallery look. The finished dimensions for our canvas prints when they have this shadow box floating frame around them, will be an additional 4cm approximately to the listed size dimensions (height and width) due to this additional frame.
See our 'Size Chart' for more information. Also, this artwork design is also available as a paper Art Print (framed or unframed) too in addition to printed on canvas, you will find this in our 'Art Prints' collection. And we can ship rolled canvas prints internationally upon request for our international customers.
All prices are in Australian Dollars AUD$
- Proudly designed and made to order in Australia
- Premium poly/cotton artist's canvas
- Printed with quality UV fade resistant eco-friendly giclee inks
- Stretched onto a 4cm thick kiln-dried craft wood timber frame
- Arrives ready to hang on your wall
- Gallery-quality finish backing wire metal d-ring hooks
- All canvas edges have mirrored artwork, for a full wrap around effect of the design
- An option to add a 5cm deep shadow box floating frame (in white, black, light timber-look, natural timber-look (all are non timber PVC MDF), or our deluxe genuine raw oak timber option)
- Care instructions: wipe down with a wet cloth
- On most sizes of our canvases the use of removable hooks eg 3M brand instead of traditional hooks is fine. This means no damage to walls, which is especially great for renters.
- All framed orders arrive safely wrapped within a protective box carton
- For International customers, upon request we can offer a price and freight quote to your location for an un-stretched (rolled canvas) shipped in a mailer tube. Please email us if you wish to know more.
For more information on our products and FAQ, see (HERE)
Dear Customers,
We hope you are all staying safe and well in this uncertain time. Just a little note to say that we are still in production during in this COVID time, and we proudly are manufacturing in Australia, to order, across several interstate warehouses.
PROCESSING OF ORDERS: Please allow 3-6 working days for us to custom print your unframed art prints, and please allow 2-4 weeks at this time for us to custom frame your framed art print or stretched framed canvas print.
ORDER DELIVERIES: Couriers from all of the companies we ship with (Australia Post Eparcel, Fastway, Allied Express, TNT etc) are not obtaining signatures in this time (will ask for verbal acknowledgement) and some delays is to be expected by our courier partners as they transit goods around the country from our warehouses (once we have custom manufactured your order). If your address has recently changed please email us firstname.lastname@example.com - if any orders return to sender , any redelivery fees will incur additional ship fees.
Where possible for framed prints - we ask your help shipping to a commercial zoned business address, this greatly helps (us) with home delivery surcharge fees. We appreciate your help here if this is a possibility.
We greatly appreciate your business in this time, and are here should you have any q's email@example.com or through our CONTACT form or 'Live Chat' us on our website 'chat' button, during business hours.
Stay safe, xo
The Print Emporium Team
Our Current Production Times in a Nutshell:
We proudly make in Australia!
E-Gift Card Voucher = instant! Shop Gift Cards HERE
Unframed Paper Art Prints = allow approx 3-6 business working days to print your print to order, pack in a protective mailer tube (rolled), then dispatch out from our warehouse based via courier.
Framed Paper Art Prints = allow approx 2-4 weeks to custom print and professionally frame, then dispatch out from our warehouse with our shipping partners i.e Eparcel Australia Post, Allied Express, TNT, Fastway couriers
Stretched Canvas Prints = between 2-4 weeks for us to print and professionally stretch and frame your canvas print, then dispatch our from our warehouse with our shipping partners i.e Eparcel Australia Post, Allied Express, TNT, Fastway couriers
Our shipping partners (Australia Post, Allied Express, TNT, Fastway etc) are experiencing higher than normal volumes at present - please expect this.
How much is shipping on each item if i buy on your website?
$15 AUD Flat Rate Per Order on all Unframed Art Prints (shipped rolled in tube)
$29 (Australian dollars) flat rate on all Unframed Art Prints (rolled and shipped in a mailer tube). We ship with Australia Post international Air Mail or a courier we feel is best to ship to your country. All parcels are shipped with a tracking number. Please note that it is the responsibility of the customer for any import taxes or duties if any incurred.
Do you ship internationally? And if so, which items?
Do I receive a tracking number # once I place an order?
You sure do! We will advise your tracking number and carrier info once your order is dispatched. And should you wish to track your order you simply go to the Order Status section under your account. Or email firstname.lastname@example.com and we can happily help you out with any q's you may have
Once I have placed my order, can i change it or edit the shipping details?
Once an order is placed, it is usually sent to our warehouse right away, so generally once it is placed, we likely cannot change it as we may have started production! However feel free to email us to check if it is possible to do so. If you ever need to edit your shipping details just let us know. Please note, we ship with Allied Express (courier) for framed items, or Australia Post Eparcel for rolled art prints in Australia. For all framed items, we ask you put a Shipping Address eg place of business or somewhere where someone is there to receive during business hours Monday to Friday. We cannot specify an exact window for the courier. Please keep an eye on your tracking number on the courier's website we sent a link for.
Business workplace addresses are preferred where someone is there to sign for the package within business hours.
Art Prints (unframed) shipped in mailer tubes are sent with Australia Post International (which in turn is shipped using the local carrier eg UK Post, UPS Post etc) or Australia Post Domestic (Australian orders).
ART PRINTS ON PAPER: White Border Yes/No
Please note: For art prints on paper, select from the dropdown White Border: YES or NO when ordering your print.
If you wish for your print to have a 'self' white border (which means a few CM of unprinted space around all four sides included in the print size dimensions) select YES, which will mean your print will look like our website images we list. This is not a mount card or matting in the frame, but a few centimetres of white unprinted border for a contemporary look when framed - and to give some breathing space between the artwork and the frame edge.
Or if you want the paper to fill the entire sheet, please select NO WHITE BORDER from dropdown. This will mean the artwork printed completely 'edge to edge' and no white border appearance. This often is chosen if you want to self-frame and your frame has a matting with a window opening. We recommend measure the inner window and choose our print and request 'NO' white border.
Scroll down to 'border info' chart below the size chart for more info.
Border Alignment Information for our Paper Art Prints (does not apply to stretched Canvas prints):
White Border width measurements in centimetres if select this option on the Dropdown:
(i.e a 75 x 100cm print, which has 5cm white borders, will mean the artwork design will fill 65 x 90cm rectangle area, and the rest as 5cm white unprinted white borders, overall print size 75x100cm, as an example).
What size do i need if buying an Ikea frame?
If buying an Ikea frame such as a 50x50cm frame, or 61x91cm frame ( or any frame with matting mount board card) that you want to keep in the frame, then we suggest check their website for the dimensions for the inner part of the matting. Then, order the size and request in the comments box on the 'Cart' page : 'print edge to edge no white border". For example , their 50x50cm frame, if leave the mount card in , would work best with our 30x30cm print (printed edge to edge, no white border). Their 61x91cm frame, if kept the mount card in, would work best with our 50x70cm print (printed edge to edge, no white border). OR if take the mount card out of the frame, we suggest just go our 61x91cm print and most customers choose YES to a white border.
Most customers choose to have a white border on their paper Art Print, simply to give some 'breathing space' between the artwork design and the frame edge, and look like our imagery on our website. But if you want the artwork to fill the entire sheet , simply choose NO WHITE BORDER from the dropdown list when ordering your unframed print. Your art print will then have no white border on the edges.
If there is a size you need, that it appears we don't list, we can adjust (no extra cost) the artwork file to print to your requested dimensions, on the 'next size up' we offer, if we list that on our Size options. Then you can trim down the paper sheet when receive , to fit your frame.
For example, if you buy the Ikea 50x70cm frame , and want to keep their matting mount card in, then you would need artwork to fill 40x50cm. We don't carry this size but we do have similar, being our A2 size (42x59.4cm). Write on the Comments box at checkout "Please adjust to print 40x50cm, rest left as white for the A2 print". Trim down edges if required once receive.
Still unsure? Live Chat us on our chat button during business hours or email us firstname.lastname@example.com with details about the frame you have bought or intending to buy yourself, and what size print we recommend. We are happy to help!


text:
Hi BeeSource Beekeepers.
I'm going to EAS and have secured a booth as a vendor. I found a reasonable room at a Kelly Ski Lodge http://www.kellyhouselodge.com/home.asp for $60.00 a night for 2 people about a mile from the conference. The rooms have several beds and bunks in each room and not all rooms have a private bathroom. I couldn't figure the webpage, so I called direct and made the reservation. There's a kitchen with a refrigerator and microwave that we are welcomed to use.
I got my plane reservations, but I'm balking at the price of rental cars from Buffalo, NY for the 5 days I'm there. Here's my proposal, my husband can't make it, and so I have an extra ticket that comes with the booth that includes 3 lunches. I'm looking for a ride Sunday night; my flight comes in at 7:30pm and leaves Friday at 6:00pm at Buffalo airport. I'll need a ride each day from the lodge to the resort and back. And if you are a single lady, I would even share my room, another savings. If you have a female friend, I think extra people are just an additional $10.00's a night. I come with two suitcases and a big smile.
If you are interested, please email me direct at [email protected].
This is going to be a great conference,
Janet Brisson
Country Rubes Screened Bottom Boards


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Harvest in Aroostook County has a long-standing tradition of making honest young men out of gangly, pimply-faced boys and strong, hard-working young women out of teenage girls. Harvest in Aroostook County can be a turning point for many young people, a series of pivotal moments, usually occurring just as the sun rises above the foggy river to the East, when they learn exactly how much Mother Earth will demand of their time and bodies. They may greet the prospect of a potato harvest job with enthusiasm as joyful thoughts of spending their own money parade in their heads. Or perhaps they revel in the break from school, imagining how much better their time spent outside the class room will be, not solving algebraic equations or deciphering dangling participles, instead kickin' around a few potatoes.
The rude and often bleary-eyed 5 a.m. awakening is that nobody really prepares them for the reality of working the potato harvest in Aroostook County. You can warn your eager teenager about how terribly their back is going to ache and throb after awkwardly leaning at a 60-degree angle for nine hours as a moving harvester belt rushes by, although they may not heed your experienced caution. You can scold them to bed by 8 p.m., encouraging them to "get some good sleep" as they roll their eyes at you and unwillingly plod to their bedroom, mumbling about not being tired. You want to remind them of how the darkest hours of morning always arrive too soon, but you don't. You will tell them to dress warmly and to always keep a spare chapstick in their pocket and an extra box of Band-Aids in their cooler, but the invaluable minutiae of potato harvest experience will come to them much the same as it came to you; the hard way.
There is no time to flat iron your morning bed-head hair or apply perfect mascara and makeup at 5 in the morning. The discomfort of reluctantly crawling out from under the warm blankets and fumbling in the dark for flannel layers and long warm socks is frigidly humbling as you barely find time to wipe the crusty sleep from your eyes and pass a toothbrush through your mouth; hopefully with toothpaste. A warm woolen hat pulled down to your ears proves difficult for a good hairdo, even if your hair normally falls in just the right places when you toss your head. Your usual routine of careful wardrobe selection and meticulous grooming is suddenly exchanged for grabbing ratty, mismatched tops and bottoms and reaching for whichever pair of gloves smells the least like a dead animal. And after just one day of cold mud and the chill of rotten potatoes seeping through your very pores, you learn the valuable potato harvest lesson No. 612: Clothing choice based on warmth and practicality is far more important than wearing the jeans that make your butt look good.
Even when you've learned to dress warmly and in layers, you still greet the early morning with a thread of hope that you'll see raindrops against your bedroom window pane as you open the blinds. You flip on the TV to "The Potato Picker's Special" on WAGM-8, squinting at the bright screen in the dark living room, waiting, hoping to see your farmer's name scroll across the bottom of the screen followed by "not digging today" or at least "late start 10 a.m." Seven days a week, all hours the sun shines and so many hours it doesn't, you sort, dig, pick and handle potatoes.
And despite it all, the dust in your eyes from the harvester fan, the dull ache in your lower back and the seemingly never-ending sea of undug potato rows, you accept and complete your job. This is harvest and there's work to be done, but also there's fun to be had. You never have quite heard a whoop of joy until you tell a tired bunch of teenagers in the potato house that the harvester has "broke down." Those are the moments we reveled in, flipping open our lunch pails, eager to see what special foods our mothers had packed us that day. Our hands were dirty as we reached into those small tin cans of Vienna Sausages, wiping the salty gel onto our pants and feeling around for the dish of mustard we hoped she didn't forget to pack. We wallowed in all the Twinkies, Nutty Bars, Pringles, Potato Stix and cans of soda our hearts desired, loving every bite of our harvest lunches and knowing our usual healthy diets would return along with our usual sleep and school schedules all too soon.
We learned a few life lessons no classroom could ever teach us and we heard jokes our mothers would have definitely disapproved of. But we were growing up and a stretch of the bridge that took us from kid to adult was on a potato farm.
We met and bonded with new friends from surrounding towns, our less-than-glamorous working conditions setting the stage for loyal friendships to grow and remain, even when we would face one another on the basketball court five months later.
There was something about working the potato harvest that set us kids apart from the rest of the state. We had the inside scoop on what sustained our local economy and we lent a hand, albeit a muddy, blistered hand, in helping to bring another local Aroostook County tradition to completion and we were stronger, healthier, wiser and richer kids because of it.
I'm the mother now and I'm the one packing the lunch pail for my 14-year-old son. I now understand how my mother must have felt when her grocery list included the junk food mine now does. And the dial on my washing machine will stay on "2nd rinse" for a few more weeks. I somehow forgot exactly how many pair of gloves a 12-hour shift requires and I also forgot that one pair of harvest work boots can stink up an entire garage. I smile when he complains about being tired and I just hold my breath when the stench of rotten potatoes follows him through my front door. But mostly, I'm proud to see that despite so many differences between his generation and mine, some things really do stay the same and I'm thankful my kid is part, truly part of Harvest in Aroostook County.
Editor's Note: The column was first published on Monday, Sept. 26, as a blog entry online at stupidgrin.blogspot.com. It is reprinted here by permission of the author Renee Chalou-Ennis of Presque Isle.


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Gemcitabine/ Trastuzumab and Gemcitabine/ Cisplatin/ Trastuzumab in Patients With Metastatic Breast Cancer
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00201760
Recruitment Status : Completed
First Posted : September 20, 2005
Results First Posted : November 9, 2017
Last Update Posted : December 27, 2017
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Breast Cancer
|Drug: Gemcitabine Drug: Trastuzumab Drug: Cisplatin
|Phase 2
Rationale: Previous studies have demonstrated the anti-tumor efficacy of gemcitabine and trastuzumab against metastatic breast cancer when given alone and in combination. Yet, research indicates that the two drugs given together work more effectively than either alone. Laboratory studies testing the combination of trastuzumab and cisplatin have shown synergistic anti-tumor activity with the two drugs. In addition, clinical studies suggest a high level of anti-tumor activity with the combination of gemcitabine and cisplatin. Researchers are testing the triple drug combination of gemcitabine, trastuzumab, and cisplatin in the current study to evaluate the potential for enhanced responsiveness in patients with Her-2/neu overexpressing breast cancer as well as comparing it to the double drug combination of gemcitabine and trastuzumab.
Purpose: This study will measure patient responses and compare the efficacy of a double drug combination (gemcitabine and trastuzumab) with a triple drug combination (gemcitabine, trastuzumab, and cisplatin) in patients with metastatic breast cancer. Side effects will be carefully assessed in patients.
Treatment: Patients in this study will receive one of two treatment combinations. A computer will randomly assign patients to a treatment group. Group one will be given gemcitabine and trastuzumab. Gemcitabine will be given to patients on days 1 and 8, and trastuzumab on days 1, 8, and 15. Group two will receive gemcitabine, trastuzumab, and cisplatin. Gemcitabine and cisplatin will both be administered on days 1 and 8, and trastuzumab on days 1, 8, and 15. Each treatment cycle (for both groups) will last a total of 21 days. All study drugs will be administered through intravenous infusions. Several tests and exams will be given throughout the study to closely monitor patients. Thorough patient exams will be given at the beginning of each treatment cycle. Imaging tests will be done every two cycles for the first eight cycles and then every three cycles until study completion. Study treatment will be discontinued due to disease growth or unacceptable side effects.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|10 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Randomized Phase II Study of Gemcitabine/ Trastuzumab and Gemcitabine/ Cisplatin/ Trastuzumab in Patients With Metastatic Breast Cancer
|Actual Study Start Date :
|February 25, 2005
|Actual Primary Completion Date :
|October 31, 2009
|Actual Study Completion Date :
|October 31, 2009
Experimental: Arm 1 Gemcitabine/Cisplatin/Trastuzumab
Gemcitabine 1000 mg/m2 iv over 30 minutes on days 1 and 8 Cisplatin 30 mg/m2 iv over 90 minutes on days 1 and 8 Trastuzumab 2 mg/kg iv over 30 minutes on days 1, 8 and 15 (if trastuzumab was not administered within the past 3 weeks, a loading dose of 4 mg/kg iv over 90 minutes will be given on the first day of cycle 1 only).
Drug: Gemcitabine
1000 mg/m2 IV over 30 minutes on Days 1 and 8.
Other Name: Gemzar
Drug: Trastuzumab
2 mg/kg IV on days 1, 8 and 15. If Trastuzumab has not been administered within the 3 weeks before starting this treatment, the first dose of Trastuzumab given on Cycle 1, Day 1 will be 4 mg/kg followed by 2 mg/kg weekly.
Other Name: Herceptin
Drug: Cisplatin
30 mg/m2 IV on Day 1 and Day 8.
Other Names:
Active Comparator: Arm 2 Gemcitabine / Trastuzumab
Gemcitabine 1000 mg/m2 iv over 30 minutes on days 1 and 8 Trastuzumab 2 mg/kg iv over 30 minutes on days 1, 8 and 15 (if trastuzumab was not administered within the past 3 weeks, a loading dose of 4 mg/kg iv over 90 minutes will be given on the first day of cycle 1 only).
Drug: Gemcitabine
1000 mg/m2 IV over 30 minutes on Days 1 and 8.
Other Name: Gemzar
Drug: Trastuzumab
2 mg/kg IV on days 1, 8 and 15. If Trastuzumab has not been administered within the 3 weeks before starting this treatment, the first dose of Trastuzumab given on Cycle 1, Day 1 will be 4 mg/kg followed by 2 mg/kg weekly.
Other Name: Herceptin
- Disease Progression [ Time Frame: 6 months ]Proportion of patients with metastatic breast cancer free of disease progression at 6 months following treatment
- Measure Response Rate of Each Drug Combination [ Time Frame: Up to 24 months ]Response rate of the of the triple drug combination therapy and the double drug combination therapy regimens.
- Number of Participants With Grades 3 and Grade 4 Toxicity Profiles of the Drug Combinations [ Time Frame: Up to 24 months ]Adverse Events will be graded in accordance with the CTCAE Version 3.0 Toxicity grading criteria
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Eligibility Criteria:
- Must have invasive metastatic breast cancer
- Tumor must be Her 2/neu 3+ by IHC (must be confirmed by Ohio State University pathology)or positive FISH
- Histological confirmation of invasive breast cancer either from the original diagnosis and/or diagnosis of metastatic disease.
- Tumor must be detectable clinically or radiographically (a positive bone scan is allowed as the only site of disease). Unidimensional measurements must be obtained whenever possible). Bone marrow only disease is not eligible for enrollment on this study.
- No evidence of congestive heart failure, symptoms of coronary artery disease, serious cardiac arrhythmias, or evidence of prior myocardial infarction on EKG or ECHO. Patients must have normal LV function and LVEF(left ventricular ejection fraction)> 50% as demonstrated by either echo or muga within the proceeding 4 weeks.
- Must have adequate renal and hepatic function documented by a serum creatinine < 1.5 x the institutional upper limit of normal (ULN), serum bilirubin <1.5 x ULN and liver enzymes (AST, ALT, or alkaline phosphatase) < 2 x ULN (< 5 x ULN if hepatic metastasis) within 21 days prior to registration.
- Patients must have an ANC (absolute neutrophil count) > 1.5, platelets > 100,000, Hemoglobin >9.0 within 21 days of registration.
- If patients are on bisphosphonates at the time of registration, with a stable creatinine over the preceding 2 months, then they may continue bisphosphonates during the study.
- No more than one prior Trastuzumab/chemotherapy or Trastuzumab/biotherapy combination for metastatic disease. Additional Trastuzumab therapy may have been given in the adjuvant setting. Prior hormonal therapy is allowed for either adjuvant or metastatic disease.
- Must be >3 weeks since administration of last chemotherapy prior to initiation of treatment on this trial. Prior trastuzumab may have been administered within one week of initiation of treatment on this trial if the last dose was 2 mg/kg. Any prior trastuzumab dosing greater than 2 mg/kg requires a 3 week washout period.
- Patients may have received prior cisplatin or carboplatin for metastatic disease.
- No CNS(central nervous system)metastasis disease.
- No active infection at time of registration.
- Pregnant or nursing women may not participate in trial.
- Patients must be informed of the investigational nature of this study and sign and give written informed consent in accordance with institutional and federal guidelines.
- ECOG (Eastern Cooperative Oncology Group)performance status < 2 at the time of registration.
- Patients may participate in a non-treatment related protocol while participating in this study.
- No other active malignancy is allowed. Adequately treated basal cell, squamous cell skin cancer, in situ cervical cancer, adequately treated stage I or II cancer from which the patient is currently in complete remission, or any other cancer from which the patient has been disease-free for 5 years is allowed.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00201760
|United States, Ohio
|Ohio State University
|Columbus, Ohio, United States, 43210
|Principal Investigator:
|Kari Kendra, MD
|Ohio State University
|Responsible Party:
|Kari Kendra, Principal Investigator, Ohio State University Comprehensive Cancer Center
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|September 20, 2005 Key Record Dates
|Results First Posted:
|November 9, 2017
|Last Update Posted:
|December 27, 2017
|Last Verified:
|November 2017
Breast Neoplasms
Neoplasms by Site
Breast Diseases
Skin Diseases
Antineoplastic Agents
Antimetabolites, Antineoplastic
Molecular Mechanisms of Pharmacological Action
Antiviral Agents
Anti-Infective Agents
Enzyme Inhibitors
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Antineoplastic Agents, Immunological


text:
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Appleby Jewellers, Dublin, stock a wide range of jewellery to suit all tastes and price ranges. Our wedding rings are handmade in our Dublin jewellery workshop by our experienced craftsmen.
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I got engaged last month. Received fabulous service from Appleby.
My engagement ring in 1978 to my wedding ring in 1979. Many trips for jewellery, watches and earring. Next generation, more to come, presents for our family. One wedding already last year. Appleby is part of our life.
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Elegant and stylish as you would expect from Appleby
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Have my engagement ring for 29 years now, so I hope the next generation have to wait another while before getting it! Unless of course I get a new one!


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Croatia, where water park meets World Heritage Site
Some years ago, in the early days of our getting to know each other, my boyfriend told me about one of his most memorable meals, at a restaurant on a rock ledge overlooking the Croatian Adriatic. He had been covering the Bosnian war and had escaped to the coast, just for a day, with a few colleagues.
They lingered over a meal of fish and a few bottles of wine, watching twilight descend like a pink veil over the water, a brief pause from the fallout over the breakup of the former Yugoslavia. The evening's calm beauty had stayed with him, and he knew he would return to this unsung sliver of the Adriatic.
Nearly two decades have passed since the 1995 Dayton accords officially ended the bloody four-year war. Croatia, once an untrodden gem (at least by U.S. standards), is now the fastest-growing tourist destination in the Mediterranean region.
Despite this reality, the lovely image rendered for me years earlier of a place less traveled had not faded. In June, our family decided to discover whether the hot spot had retained its allure. We focused mainly on the lower Dalmatian Coast, eager to immerse ourselves in the stretch from Split in the north to Dubrovnik in the south.
We flew into Venice, Italy, a city we loved and that provided a mission for our 9-year-old daughter: to see how many canal bridges she could cross without repeating any. Three brilliantly sunny days and 84 bridges later, we drove from Italy to Plitvice Lakes National Park, our first destination in Croatia.
We had not initially included Plitvice in our plans, but in reading about Croatia's wonders beyond the famous shoreline, we decided not to overlook this lauded park. As we drove, the country's splendors quietly unfolded before us, with miles and miles of pine-covered mountains flanking the highways, vast meadows, bucolic country lanes and verdant hillsides sprouting Alpine-style houses.
Exploring Plitvice the next morning rewarded us with a veritable water world. The park is a UNESCO World Heritage Site, a deserved designation. Its 12,000 acres of rich, variegated greens, punctuated by 16 turquoise lakes, crystalline streams and dozens of waterfalls, provided an ethereal backdrop as we walked along miles of wood-plank paths. Alas, no swimming allowed, but the temptation was huge, especially when we grabbed a rare moment of solitude apart from the other tourists gazing at all that liquid beauty.
That evening at dinner, thinking about the natural bounty that had surrounded us at the park, we agreed that the Plitvice detour had been worth it.
Fueling up the next morning with one of many excellent cappuccinos we ordered at cafes or rest stops along the way (Italy has some serious competition from Croatia when it comes to a well-executed espresso or cappuccino), we took off for our next stop, the much-heralded city of Dubrovnik, yet another Croatian contribution to the list of UNESCO World Heritage Sites.
Many hours later, cruising along narrow roads that offered vertigo-inducing — and dreamy — views of the coast, we reached our hotel, a Radisson Blu resort on the outskirts of the city.
The modern hotel appeared out of place with the surrounding Mediterranean landscape and architecture, but the view from our spacious room and a baptismal dip in the clear Adriatic erased all judgment about the resort.
The water was a touch chillier than expected, but we quickly acclimated and over the next few days spent hours floating in the sea, skipping stones or swimming to an outcropping of rocks that begged to be used as a platform for jumping.
Other resort offerings, such as a rock-climbing wall, kids' center and the requisite spa upped the wow factor, as did two inviting pools dramatically perched above the pebble beach. This was an easy place to be lulled into a vacation state of mind.
Not so relaxing was the spectacular but overcrowded, over-commercialized Old Town of Dubrovnik, where we were greeted by buses unloading a profusion of tourists and vendors hawking a variety of water and land activities.
Once inside the pedestrian-only town, a contained maze of stone alleyways and stairs packed with cafes, low- and high-end shops, galleries and apartments, we made a beeline for a pathway that seemed to float along the top of the City Wall.
Here, with one movie-ready vista after another, we enjoyed the tableau of red-roofed houses rising above the smooth blue sea. We saw vestiges of the Croatian War of Independence (as it is called here) in the 1990s, mostly in the form of crumbling, bombed-out or fire-damaged buildings; a small but high-impact museum commemorating Dubrovnik's fallen soldiers is within Old Town's stately wall.
Later, at a harborside restaurant, we ordered fresh local fish and octopus accompanied by a salad of arugula and olives, a classic Mediterranean repast, and lingered to watch the silent navigation of boats and ships at sunset, the chaotic day melting into a peaceful evening.
Our next stop, Split, is aptly named: It is a modern port city sharing valuable real estate with Roman ruins, the centerpiece of which is the well-preserved Diocletian's Palace (also a UNESCO World Heritage Site). The vast structure, built by Roman emperor Diocletian between the late 3rd and early 4th centuries after abdicating his power, puts to rest any notion of scaling back in retirement. We wandered the snaking alleys and marveled at the improbable blend of ancient backdrop and trendy stores, restaurants and camera-wielding tourists.
We stopped at Split primarily to catch a two-hour ferry ride to the island of Hvar. We had wondered whether Hvar was a wise choice; for better or worse, it has become a hub for the glitterati. Indeed, it offers sophisticated hotels and eateries, along with the yachting crowd, in Hvar Town, the island's largest town and main arena for the social set.
For the more nature-oriented, the reward of gorgeous (mostly pebbly) beaches and coves remains part of Hvar's appeal. Opportunities to sail, kayak or swim abound — it's a watery playground surrounding hills covered with lavender and pine and olive trees.
Our comfortable accommodations, one of two apartments in the bottom floor of a home, were across the street from the sea. A quick walk down the craggy white rocks that rim the island and a dive into the water satisfied our never-ending quest for liquid immersion.
We were not alone — no matter where we wandered on the island, by car or foot, people were in the water, some of them swimming far from any beach or jumping-off point. Where's there's water, there's a way, so it seemed.
When we ventured farther afield, our gracious hosts, who lived in the upper apartment, provided us with great recommendations. We took leisurely walks into Hvar Town to purchase cheese, bread and the tastiest tomatoes I've ever had to enjoy on our patio.
A morning trek to the fortress, its commanding location above Hvar Town, offered unparalleled views of the harbor and the small Pakleni Islands beyond. Inside the stone walls, our daughter wondered about the tiny, water-view windows in the half-dozen or so claustrophobic jail cells — did they make life bearable for the prisoners or drive them insane with the desire to escape?
On our last evening, we had a seafood feast at the rooftop restaurant Luna in town, then gathered with locals and other visitors to listen to an orchestra playing classical music in St. Stephen's Square. If the beautiful people had overtaken the town, we didn't notice.
The northern town of Opatija was our last stop. After an early-morning return to the mainland from Hvar, we left the Dalmatian Coast and began the four-hour drive to the northeastern corner of the Istrian Peninsula. We wondered how Opatija would stack up against the southern points we had visited.
Our Hvar hostess had lived here years ago and told us to expect an atmosphere more reminiscent of Croatia's communist past, when the country was still part of Yugoslavia. She assured us, though, that the setting was another example of Croatia's coastal riches.
We quickly checked into our hotel, donned swimsuits and dashed to the water, where we swam with other families and zipped down a giant slide resting beside a cove.
That evening we strolled along the Lungomare, the ribbon-like promenade fronting the Adriatic, stealing a little more time to enjoy the soft summer air and pleasant hum of activity.
And our hostess' take on Opatija? Some of the architecture, including our austere, block-like hotel, definitely recalled a certain 20th century communist style; in contrast, though, were pastel Victorian homes dotting steep green hillsides and grand seaside hotels with vistas stretching across the Kvarner Gulf, the enchanting scene straight out of a fairy tale.
Earlier in the trip, on the stone patio of a restaurant where the setting sun cast firelight over the water, I wondered how this scene would compare with my former boyfriend's recollection. So I asked him.
"It's just as I remember it," my husband said, lifting his wine glass in a toast, all of us ready to dine on fish straight from the sea.
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On the morning of Monday 6 October 2008, so the story goes, Yohan Blake packed his bags and left Danny Hawthorne's house for the last time. It was not an easy thing to do. Blake had spent three years living with Hawthorne, his mentor and school sports coach. In that time they had won a lot of medals and broken a lot of records together.
Blake was on the brink of becoming a great sprinter, and Hawthorne was dreaming of making the step with him. He talked to the local press about how he was considering quitting his job at the school to become Blake's full-time coach on the international circuit. And then Blake walked out.
The timing was not accidental. Just six weeks earlier Usain Bolt had won the sprint double at the Beijing Olympics, both in world record times.
"That," Blake thought, "is what I want."
"I don't know anything," the hurt Hawthorne told the press at the time. "Nobody has said anything to me." He would, eventually, get a call from Blake's parents, Veda and Shirley, explaining exactly where their son had gone. He left Hawthorne to join Bolt's training group at the Racers Track Club in Kingston. He did what he believed he needed to do, despite what it cost.
Not long after that, early in 2009, Bolt gave an interview to Television Jamaica's Morning Time show. The host asked him if there were any athletes he saw as a potential threat. Bolt thought about it, and answered. "Blake is the man. He's very, very determined. He works very hard and in the future, he'll be very good because you can tell that he really wants it." Bolt soon took to calling Blake "The Beast".
"You know why Usain calls me 'The Beast'?" Blake said. "Because when you're sleeping, I'm working, I'm toiling through the night. It's what great men do."
When Blake was growing up in Bogue Hill he went by another nickname – Claude. That was what his family always called him. Blake is the sixth of Veda and Shirley's seven children. "I wasn't born with a golden spoon in my mouth," Blake said. "It was a really tough life. So many times, we had no money to even get to school. I'd have to find empty beer bottles to sell and spent hours carrying water on my head because we had no water at home. It gave me strength, which helps me today."
Back then Blake was more interested in playing cricket than he was in anything else. "As a boy, I'd rather have played for the West Indies than go to the Olympics," he said. "It was my dream. When I was starting out at 12, I didn't go to school a lot so I was putting up a stick in the yard and bowling at it." He still plays 20-over cricket in the St Catherine League on Sundays. Bolt also fancies himself as a quick bowler, and the two have a rivalry there as well. "Usain thinks he's much better than me but even though he gets more bounce and pace because he is really tall, I'm better. I'm pretty quick, fast through the air."
The school that Blake was skiving from was Green Park All-Age, in Clarendon. The principal was a man named O'Neil Ankle, who described himself as "a tough taskmaster". But he was also quick to reward achievement in his pupils. He had a "brag board" put up to record their achievements, and would reward them with buttons that said "World Changer". He watched Blake play cricket, and reckoned that he could see the makings of a sprinter in the way the boy ran in to bowl.
Ankle sent Blake off to Hawthorne at St Jago high, which had a reputation as a great school for athletes. "O'Neil told me that he saw something special in him," Hawthorne remembers. "He thought that St Jago was the right place for him to nurture that talent." It was only then, Shirley Blake remembers, that her boy began to show any interest in running. The family had moved down to a village called Bullet Tree. "He had this friend," Shirley says, "and the two of them would run from Bullet Tree to Old Harbour."
Hawthorne recalls that Blake was "not impressive at the all-age championships." But the coach was impressed with the kid's dedication. "He took training very seriously, and only missed it because of reasons beyond his control." That too was a debt to his parents. "I faced a lot of obstacles growing up, I see where my parents suffered to bring me here," Blake said when he was 16. "It would really hurt me if I waste my time when I know I have the potential to put myself in a good position to help them in the future."
Soon Blake's talent began to show through. He lost a few major races because of his nerves, notably at the World Junior Championships in 2006 and 2008. But his times continued to improve. In 2005 he set a personal best of 10.56sec in the 100m. The next year he lowered it to 10.33. Then, in the heats of the Carifta Games in 2007, he broke Raymond Stewart's Jamaican junior 100m record of 10.19. He shaved a single hundredth of a second off a mark that had stood for 28 years, that had been too quick for both Bolt and Asafa Powell at the same age. In the final he went quicker still, running 10.11.
That success threw Blake. When he arrived at Racers Track Club he was, according to the coach, Glen Mills, in a mess. "The first thing when we got him, he had a back and a hamstring problem that we had to attend to in his first year." Mills thought Blake had been scarred by an unexpected defeat at the high school championships in 2008. "When he started in his first meet, he froze, the gun fired and he didn't run. So we had to be patient with him and work on him both mentally and physically. We corrected his back, strengthened his hamstrings and then once that was in place, we started to work on him biomechanically."
Mills identified the problems Hawthorne had not been able to see. "His body was sitting down and arm movement wasn't going far back enough, which is where acceleration takes place," Mills explained. "Over the years, we worked incrementally on those things." Soon Blake started to fly. In May 2009, he became the youngest man ever to run under 10 seconds, when he clocked 9.93 in Paris. The next month, however, his career took its first serious knock when he tested positive for methylxanthine.
The stimulant was not on the World Anti-Doping Agency's prohibited drugs list at the time, but was added to it shortly afterwards. Blake was cleared of any wrongdoing but Jamaica's anti-doping commission insisted he serve a three-month ban regardless. That positive test will always provide evidence for the sceptics, but the circumstances were far from black and white. Several athletes around the world tested positive for methylxanthine at the time, including the South African rugby players Bjorn Basson and Chiliboy Ralepelle. It was a common ingredient in both nutritional supplements and nasal sprays, though it was often listed under a different name.
Blake says that he unknowingly ingested it while using an energy supplement. The positive test meant he missed the 2009 world championships in Berlin, when he would have been part of the 4x100m relay team.
He made up for that in 2011, when he won the world 100m title in Daegu after Bolt was disqualified. No one knows why Bolt false-started, but many suspect it was because he was spooked by Blake's speed. Blake made an even bigger statement in Brussels a few weeks later, when he ran the second-fastest 200m in history, 19.26. Bolt was there to see that one too, and he slapped his hand over his mouth in shock when he saw the time.
Three years ago, when Bolt gave that TV interview praising his young partner, no one paid him much mind. Now the two have stopped taking training sessions together. Their rivalry is too intense. Blake is the world 100m champion. He is ranked No1 in the world this year at both the 100m and the 200m, and most tellingly of all, he has beaten Bolt in both events at the Jamaican trials.
Blake is not on Bolt's shoulder any more. He is right up there with him, matching him stride for stride.


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Hello all,
I'm working on a homework problem that's due this evening. The prob asks to create a toString method that returns a "nicely formatted, multi-line description" of the class objects I created. The class is called "Book" and its objects are title, author, publisher, and copyright date. My toString code trying to use \n for a new line is as follows:
return ("Book - Title: "+ title\n"Author: "+ author\n"Publisher: " + publisher\n"Copyright: " + copyright);
This gives me several errors: syntax errors on the token n, syntax error insert ")" to complete expression, n cannot be resolved to a variable, syntax error on token "Invalid Character", ( expected...where am I going wrong? The only example I found in my text book uses the \n sequence in a System.out.println method. Can this even be used in a toString method?
I'm veeeeery new to java/code writing so any help would be much appreciated.


text:
Search results
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text:
$ 45.00
Twine & Twig Mini pillows are created from vintage African mud cloths and are embellished with cowrie shells. Back features envelope enclosure, upholstery-grade linen and our signature branded suede tag. Each textile is one-of-a-kind and subtle variations, such as spots or marks, misaligned prints and slight wear, may occur. We have handpicked each textile and believe these variations add a raw beauty to each pillow.
SIZE: 13 x 13 Square
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text:
Hi...have not done much reversing as of late, especially since RCE closed down. Taking an interest in tracing the usbxhci.sys driver for W10 to see if I can adapt it for use on Win 7 on an 8th generation Intel chipset.
The chipset is an Intel B360 and it seems Intel no longer makes drivers for their own chipsets, having deferred to Micro$oft.
Bit of history, then questions. I have loaded Win 10 on an Asus B360M-C mobo which uses an i5 - 8200 8th generation processor. I wanted to load an installed win 7 OS which I had on a hard drive. Surprisingly, it booted straight to the logon screen, graphics and all, using stock SP1 drivers. I had to rig USB to PS/2 adapters to get my mouse and keyboard working (another USB keyboard in a USB port to get past the boot screen) but after that I could log in and got straight to the desktop.
Most of the stock W7 drivers seemed to be working fine....all but the USB drivers which require a USB 3/3.1 driver. Of course, m$oft has crippled W7 by not supplying the USB drivers. They claim to be protecting W7 users due to a lack of updates, but if that's the case, why are they detecting W7 on 7th and 8th gen chipsets and blocking those users from updates? And why do generic drivers work on this mobo for W10 and not W7?
1)What is currently the best dissassembler/debugger? I have never learned Olly and did get started on Windbg. IDA, of course, is still there and I notice Ilfak has released a free version of IDA 7.
2)If I start Olly what is the best platform? Does it work on win 7 and 10? The original seems pretty dated but Olly 2 does not seem to be popular for some reason.
3)If kayaker is still out there, how's the paddling? Fixed ice yet to run on W7?
4)If blabberer is still out there I could use your help getting going on windbg....again!!!


text:
GIMPshop 2.2.8
GIMPshop is a modification of the free/open source GNU Image Manipulation Program (GIMP), intended to replicate the feel of Adobe Photoshop.
Its primary purpose is to make users of Photoshop feel comfortable using GIMP.
It shares all GIMP's advantages, including the long feature list and customisability, while addressing some common criticisms regarding the program's interface: GIMPshop modifies the menu structure to closely match Photoshop's, adjusts the program's terminology to match Adobe's, and, in the Windows version, uses a plugin called 'Deweirdifier' to combine the application's numerous windows in a similar manner to the MDI system used by most Windows graphics packages. While GIMPshop does not support Photoshop plugins, all GIMP's own plugins, filters, brushes, etc. remain available.
Due to the changes to the interface, many Photoshop tutorials can be followed in GIMPshop unchanged, and most others can be adapted for GIMPshop users with minimal effort.