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LAKE BUENA VISTA, Fla., Sept. 18, 2013 /PRNewswire/ — B Hotels& Resorts introduces the first B Resort and lifestyle hotel to the Lake Buena Vista area, with a transformation of the former Royal Plaza hotel. A joint venture between InSite Group and Cube Capital, the B Resort, located in the Walt Disney World Resort will open early 2014 and showcase 394 completely redesigned guestrooms and public areas that feature elegant yet playful decor, alluding to the surrounding destination and its imagination-inspiring attractions. Renovations are taking place throughout the property including the 25,000 square feet of function space, common areas, pool and outdoor terrace, and will introduce an innovative culinary concept and full service spa to the Downtown Disney resort area. A complete transformation resulting in a new destination resort, the B will be a welcomed addition to the area for seasoned travelers, families and discerning adults looking for refined yet approachable lifestyle accommodations.
The vision for B Resort's cutting-edge design and future programs calls for visitors to feel open to express how they aspire to be during their visit to the Orlando area. A balance between casual sophistication, lifestyle elements and innovative offerings has been struck through the artfully employed design details provided by a collaboration of VOA Associates Incorporated and InSite's in-house design team.
B Ambiance
Entering the newly redesigned resort, guests' senses are immediately activated with a specially developed scent of white tea and thyme. A cascading waterfall takes center stage in the majestic lobby, creating a relaxing environment. Spacious public areas are conducive to business and socialization with soothing and sleek interior decor, intimate and flexible seating arrangements, FreeB Wi-Fi (complimentary high-speed internet access), courtesy guest iPads and other available entertainment options.
B Rested in Style
With its debut, the B Resort will unveil 394 completely renovated guestrooms within the 17-story tower and connecting Lanai building. There will be two Master Poolside Suites, five Master Suites, 17 one-Bedroom Suites, and 20 family-friendly rooms with bunk beds. Master Suites were designed with business executives and extended stay guests in mind and contain an expansive living and entertaining area with kitchenette or wet bar and formal dining space with seating for up to eight.
All guestroom interiors fuse stylish and timeless designs and include a mini fridge, in-room safe, B Treated snack box, the latest high-tech offerings such as FreeB Wi-Fi, HD LED interactive flat-screen TVs, and electrical power hubs with USB, HDMI and international outlet plug ins. As part of B Hotels& Resorts' B Humane program, all guestrooms come furnished with a plush green frog, that represents the native Florida Gopher Frog, a protected species. The frogs are available for "adoption" to take home at check out, with a portion of the sale's proceeds donated to a Florida environmental foundation.
B Nourished
In an evolving relationship with Jeffrey Chodorow of China Grill Management, B Resort's farmhouse chic signature restaurant offers an innovative culinary experience that redefines classic American barbeque. A cross-country selection of BBQ favorites, smoked meats, fish and poultry will be offered both from an a-la-carte menu and an original buffet presentation. Through a large window in the restaurant, diners can peek in on the action and watch as the culinary team smokes mouthwatering meats and rotisserie chicken.
Other food and beverage outlets at the resort include a poolside bar and grill and a grab 'n go cafe with an ice cream parlor.
B Indulged, B Active or Just B…
The first full-service B Indulged spa will make its debut at the B Resort in Lake Buena Vista and add to the overall resort-style environment. A perfect respite after fun-filled days at the parks or rigorous meetings, the spa includes four treatment rooms, including one for couple therapies. The serene design palette features upholstery and accent pieces shimmering with an opalescent patina, while a separate hair salon, nail boutique, relaxation lounge, men's and women's locker rooms, and B Active Fitness Center complete the experience.
Other amenities at the resort include four tennis courts, a zero-entry, mineral-water pool with multiple interactive water elements, private cabanas, outdoor fire pits for s'mores and more, kids programs, an interactive area in the lobby with games and Monscierge screens (the interactive resort/destination guide providing guests with touch screen technology and access to maps, photos, restaurant menus and more), FreeB Wi-Fi throughout the property, valet and self-parking on site and complimentary shuttles to the Walt Disney World Resort theme parks.
Meetings and Social Events
Over 25,000 square feet of flexible function space, including two ballrooms, divisible into nine breakout rooms, and a poolside terrace and courtyard, make the B Resort an ideal venue for meetings, events and weddings when it opens in 2014. Catering menus will be designed by China Grill Management, and a separate banquet kitchen allows for the hosting of kosher and other culturally authentic functions. The Grand Ballroom accommodates up to 1,000 guests in theatre style and up to 750 for banquets. Dark espresso wood finishes and textured wall coverings are offset with sparkling crystal drop chandeliers, and provide an overall neutral backdrop to complement any specially designed event decor.
B Resort, managed by Crescent Hotels& Resorts, is scheduled to make its debut in early 2014. For more information, visit www.bresortlbv.com or contact the hotel at (407) 828-2828. B Resort, located in the Walt Disney World Resort, 1905 Hotel Plaza Blvd, Lake Buena Vista, FL 32830
Headquartered in South Florida, B Hotels& Resorts offers two hotel categories targeting savvy, sophisticated and experience-driven guests. Full-service B hotels offer a Lifestyle without Attitude™ experience, while b2 hotels combine comfort and style at a value for an experience defined as Lifestyle within Reach™.


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"Pataki's Budget Leaves Transit Projects In Doubt" read the headline in the New York Times online. (In the newspaper itself, the article, with a slightly different headline, was the lead story of the day).
Of course, many of these projects have long been in doubt, even as more and more people become convinced of their importance. A report released recently by the Rudin Center at NYU on commuter rail and subway expansion needs (in pdf format) concluded that, "Expanded transportation capacity is of vital importance to enable future economic and employment growth in the Manhattan central business district."
It has been clear that one of the two major issues for transportation in 2005 will be financing the operation and expansion of the transit system. (The other is doing the same for the highway system.) The question has been: Where is the money going to come from?
As summarized here two months ago, the city's Independent Budget Office and a respected civic group, the Regional Plan Association, discussed a range of ways to raise the money.
Last month, Peter Kalikow, the chairman of the Metropolitan Transportation Authority, called on Governor George Pataki to support increased taxes and fees on businesses, gas and mortgages that would keep the transit system in good working order and also fund such expansion projects as the Second Avenue Subway and the connection between the Long Island Rail Road and Grand Central Terminal. Stepping forth in more of a public leadership role than any MTA head during Pataki's tenure in Albany, Kalikow warned that failure to fund at least the $17 billion core program would begin the transit system's "descent" toward deterioration and financial crisis.
When the governor released his budget on January 18th, he proposed adopting two of Kalikow's specific recommendations: an increase in the mortgage recording tax and increased motor vehicle fees. Pataki also asked for legislation to authorize innovative financing opportunities. He cited three examples from other states. Two involve the sale or construction of toll roads (in Chicago and Virginia), and thus are financed by motorist tolls. The third involves private investment in the Las Vegas monorail.
Overall, however, the governor's budget came up well short of the MTA's needs. The governor proposed to cover $15 billion of the $17 billion that transit officials consider essential.
Some transit advocates were cheered that Pataki proposed new fees to pay for transit improvements, while others criticized him for inadequate funding. The budget, which is subject to revision after a public hearing, is perhaps best viewed as the opening gambit in Albany's long budget game, plagued for years by late budgets. Anyone keeping a scorecard on the progress of budget discussions might look for the following:
- When will the governor become more specific about additional revenue sources needed to plug the gap he left, and even to increase total spending from his proposed levels?
- Do revenue sources (fees, taxes or otherwise) provide new money and a long-term solution, unlike the crushing debt burdens that financed the transportation authority's previous capital program?
- Do revenue sources require the governor and legislative leaders to gain broad political support, as a broad-based tax would, or is there continued effort to hide the pain through fees and taxes that most people do not pay (like the mortgage recording and business taxes)?
As New York struggles with how to pay for its transportation needs, a number of other cities around the country moved forward on major transportation expansion projects. In the November elections, voters approved new taxes to pay for system expansions, meaning that new, "real" money will be available for real projects. The Center for Transportation Excellence, a non-partisan policy research center in Washington DC, reports that:
- Phoenix area voters approved a 1/2 cent sales tax extension and a $16 billion regional transportation plan that will fund 30 additional miles for the region's light rail system and expanded and improved bus services.
- Denver voters approved a 4/10 cent sales tax increase to construct 119 miles of new light rail and commuter rail lines; 18 miles of Bus Rapid Transit service, new parking at transit stations and expanded bus services.
- San Francisco East Bay area voters approved a "parcel tax" of $2 per parcel per month to underwrite continued bus services.
- San Diego voters adopted an extension to the 1/2 cent sales tax through 2028 to raise $14 billion for transportation improvements.
Each of these metro areas suffers from high levels of traffic congestion and are turning to transit expansions to help alleviate gridlock on their highways. Perhaps New York, blessed with the most extensive transit system in the country, can take inspiration from voter approval of higher taxes in other regions. New York can not only maintain the existing system but also fund forward-looking system expansions.
Bruce Schaller is head of Schaller Consulting, which provides research and analysis about transportation, and is also a Visiting Scholar at the Center for Transportation Policy and Management at New York University.

subset: commoncrawl


text: I have an exercise to work on from a book. I have to overload some operators for a HugeInteger Class. I am having problems figuring out the division. The numbers are stored in an integer array. I am having trouble figuring out how to do division manually. Any tips that would get me started?


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Associate in Science in Early Childhood Education
Degree Information
The Early Childhood Education program prepares students educationally to immediately become assistant teachers, teachers, or site directors in early childhood settings such as early learning (child care) centers and preschool programs (Professional Track). It also prepares students to transfer to bachelor degree programs in early childhood education, child development, or elementary education (Transfer Track).
The curriculum balances general education courses with courses specifically designed to develop an understanding of the learning needs of young children. Many opportunities for "hands-on" experiences with children give students a firm foundation for immediately entering the workforce or continuing their formal education.
After completing the Associate in Science of Early Childhood Education degree at Lackawanna College, students will be able to:
- Explain the history, foundational theory, governance, and persistent issues in education, as well as the responsibilities and behaviors of a well-organized and responsible educator
- Define, analyze, differentiate, and create effective assessments that align with objectives appropriate for children from Birth to Grade Four, considering student strengths and weaknesses
- Self-assess and reflect on teaching effectiveness in light of student's learning styles, development, and ability levels and use that reflection to contribute to current debates in early learning curricular and assessment reform
- Identify and apply knowledge of all developmental domains as well as the implications of that development for effective teaching and learning
- Demonstrate application of models, theories, and laws of inclusive education in curriculum and lesson planning and identify and demonstrate application of assistive technology and other strategies to implement IFSP goals
- Explain and demonstrate how educational theory informs best practice through the creation and application of developmentally appropriate, standards-based learning environments and materials
- Differentiate, discuss, and create classroom management plans with consideration of teacher behavior in time management and organization in space, methods, and materials adaptations; and expectations for student behavior with age-appropriate, educationally-focused accountability
- Describe and evaluate the process and progress of children's literacy acquisition, including the role of literature in cross-curricular activities
- Establish and implement respectful, collaborative relationships among family, school, peers, community, and media, while identifying laws that govern the release if student information
- Carry out play-based lessons and assessments
- Demonstrate knowledge, skills, ethics, and experience sufficient to be "work ready" as well as "transfer ready"
- Participate in level I and II field observation to analyze and apply program level objectives
View the curriculum guide (for students beginning in Fall 2020) – PDF
Review the Early Children Education credentials portfolio requirements.
This degree program is offered at our Scranton campus, Lake Region Center, and Towanda Center.


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2010 Lecture 15
- 1 Cell Cycle
- 1.1 Introduction
- 1.3 Objectives
- 1.4 Background Reading
- 1.5 Recent Nobel Prizes
- 1.6 Prokaryote Division
- 1.7 Cell Lifespan
- 1.8 Cell Cycle Major Phases
- 1.9 Cell Cycle- Stages
- 1.10 Cell Cycle Differences
- 1.11 Cell Cycle Regulation
- 1.12 Cyclins
- 1.13 Cyclin-dependent Kinases
- 1.14 Cell Cyclin Changes
- 1.15 Regulator Checkpoints
- 1.16 Oncogenesis
- 1.17 References
- 1.18 External Links
- 1.19 Movies
- 1.20 2010 Course Content
Cell Cycle
This lecture will introduce the cell cycle, which is the entire life of a cell from birth to death. This overall topic is too large for a single lecture, so will focus on our understanding of the regulation of the cell cycle. Later lectures will cover cell birth (cell division), differentiation (signaling, development) and death (2 lectures) in more detail.
--Mark Hill 15:33, 1 December 2010 (EST)
The content below (in particular cell cycle regulation) is in more detail than you require, I will add a link to a more relevant summary. to the PMP online notes page.
Lecture Audio
The University has a system for automated recording of lectures called Lectopia. Lectopia requires login using your student number and unipass. I will be adding the link to each iLecture Audio following the Lecture. Due to the automated recording method, most lectures begin 4-5 minutes into MP3 recordings and occasionally stop before the end of the lecture. 2010 All Audio Files
MH - note that content listed below will not match exactly current lecture structure but has been selected as having similar content.
- 2009 Lecture 15 2008 ANAT3231 Lecture PDF lecture14-15 1 slide/page (view) | 4 slides/page (print) | 6 slides/page (print) | text (print)
- Understanding of the main stages of the cell cycle
- Broad understanding of different cell lifespan
- Understanding of the differences between embryonic and adult cell cycles
- Understanding of the key regulators of cell cycle
- cyclins
- cyclin dependent kinases
- Broad understanding of abnormal cell cycles
- How the cell cycle is monitored
Background Reading
Nature - Cell Division Milestones
Recent Nobel Prizes
2001 - Control of the Cell Cycle
- Leland Hartwell (born 1939), Fred Hutchinson Cancer Research Center, Seattle, USA, is awarded for his discoveries of a specific class of genes that control the cell cycle. One of these genes called "start" was found to have a central role in controlling the first step of each cell cycle. Hartwell also introduced the concept "checkpoint", a valuable aid to understanding the cell cycle.
- Paul Nurse (born 1949), Imperial Cancer Research Fund, London, identified, cloned and characterized with genetic and molecular methods, one of the key regulators of the cell cycle, CDK (cyclin dependent kinase). He showed that the function of CDK was highly conserved during evolution. CDK drives the cell through the cell cycle by chemical modification (phosphorylation) of other proteins.
- Timothy Hunt (born 1943), Imperial Cancer Research Fund, London, is awarded for his discovery of cyclins, proteins that regulate the CDK function. He showed that cyclins are degraded periodically at each cell division, a mechanism proved to be of general importance for cell cycle control.
1989 - Cellular Origin of Retroviral Oncogenes
- Michael Bishop and Harold Varmus used an oncogenic retrovirus to identify the growth-controlling oncogenes in normal cells. In 1976 they published the remarkable conclusion that the oncogene in the virus did not represent a true viral gene but instead was a normal cellular gene, which the virus had acquired during replication in the host cell and thereafter carried along.
Prokaryote Division
- Binary Fission - and seen in eukaryote mitochondria
- Asexual reproduction - replicates original cell to produce two identical cells
- Grow in numbers exponentially - adequate nutrients and a fast life cycle
- single organism can multiply into billions
- High mutation rate of bacteria
Appear to involve proteins that are homologs of eukaryotic cytoskeleton proteins. Prokaryotic Cytoskeleton Filaments
Cell Lifespan
- Body Cell Types - about 210 types
- Lifespan
- Born
- Differentiate
- Function
- Die or Divide
Cell Lifespan Examples
Neutrophil 6-7 hours circulating 4 days in tissue Red blood cell 120 days Brain neuron, heart 50 - 100 years
Lifespan Processes
- Birth - Mitosis (except germ cells - Meiosis)
- Growth - Expression of genes and proteins required to grow the cell, its organelles and cytoskeleton
- Function - Expression of tissue specific genes and proteins
- Division - DNA during cycle, whole cell in Mitosis
- Death - Apoptosis (programmed cell death) Necrosis (un-programmed cell death)
Movie: Embryo Mitosis Movie: Cell Death (Apoptosis)
Cell Cycle Major Phases
- Mitosis (M phase)
Cell birth(division) small time of cell cycle
- Interphase
Most cell life Cell growth, function DNA synthesis organelle development
Cell Cycle Time cell comes into existence until that cell divides again Rapidly growing human cells 20-24 hr Liver cells 1-2 year Neurons 1 only Quiescent G0
Cell Cycle- Stages
Rapidly dividing cell (20-24hr)
- M phase 1 hr
- G1 Phase
- cellular growth 9hr
- Most variable time
- Can exit to G0
- S Phase
- DNA duplication 9hr
- G2 Phase
- growth prepare for mitosis 4 hr
Cell Cycle Differences
Early Embryonic Cycle
- no growth occurs
- each daughter cell is half the size of parent cell
- cycle time is very short
- S phases and M phases alternate without any intervening G1 or G2 phases
G0 Phase
- exits the cycle at G1 (cancer cells do not enter G0)
- cell can leave the cell cycle (temporarily or permanently)
- temporarily - quiescent
- permanently - terminally differentiated
- cell will never reenter the cell cycle
- carry out their function until they die
- not simply the absence of signals for mitosis
- active repression of the genes needed for mitosis
Cell Cycle Regulation
Cell proliferation is strictly regulated
Unregulated/abnormal proliferation is oncogenesis or Cancer
An overview of the cell-cycle control system
Cell Cycle- External Regulators
- Cell replacement in different tissues
- regulated by growth factors
- can be specific for specific cell types
Growth Factors and Cell Cycle Progress
- External factors can also regulate progression through cycle
- Growth factors primarily act on cells in G0 and G1
- The restriction point is the timepoint in G1 when cells no longer respond to withdrawal of growth factors by returning to G0, but progress to S phase.
- thought to involve retinoblastoma protein (pRb)
Growth Factor Model
- Fibroblasts in culture
- Serum (Prepared by clotting)- Proliferation
- Plasma (Prepared by centrifugation, no clotting)- no proliferation
- Clotting
- allows platelets to release secretory granules
- Platelet-derived growth factor (PDGF)
- Connective tissue cells express PDGF receptors which bind the small PDGF glycoprotein
Other Growth Factors
- Interleukin-2 (IL-2)
- Stimulates T lymphocytes
- Nerve Growth Factor (NGF)
- Promotes neuronal survival and growth
- Epidermal Growth Factor (EGF)
- Vascular Endothelial Growth Factor (VEGF)
- Insulin-like growth factors (IFG-1, IGF-2)
Cell Cycle- Internal Regulators
1980s - studies in Xenopus eggs and starfish oocytes purified M phase-promoting factor (MPF) from and the identification of its components as cyclin B and CDC2 (also called cyclin-dependent kinase
Cyclins are synthesized and degraded each cell cycle (hence the name)
Cyclins and Cyclin-Dependent Kinases need to interact for cell cycle progression Cyclins and Cyclin-Dependent Kinases
Cyclin D
- cyclin D1, D2 and D3
- expression induced by growth factors stimulation
- serum growth factors to quiescent cells promotes transcription of the cyclin D1 gene
- Cyclin D1 then binds Cdk4 and Cdk6 in early to mid-G1 phase
- phosphorylate and inactivate retinoblastoma protein (pRb)
- also acts as a cofactor for several transcription factors in numerous cell types
Cyclin D1 is a proto-oncogene
- mutations are associated with cancer progression
- as a regulator of G1 to S-phase transition
Cyclin E
- required for transition from G1 to S phase
- Cyclin E binds to G1 phase Cdk2
- Cyclin E/Cdk2 complex phosphorylates p27Kip1 which then degrades
- an inhibitor of Cyclin D
- activation of Cyclin E gene can be blocked by the cdk inhibitor p16 (Cyclin-dependent kinase inhibitor 2A)
- tumor suppressor protein
- expression of Cyclin A then increases for progress to S phase
Cyclin A
- accumulates from early S phase
- role not fully understood, required for S phase progress
- Cyclin A binds Cdk2
- disappears ahead of cyclin B during mitosis
- can bind to both Cdc2 and Cdk2
Cyclin B
- accumulates from S phase
- Cyclin B forms a complex with Cdc2
- complex is kept inactive by phosphorylation of Cdc2
- abruptly activated by Cdc25 during mitosis
- cyclin B is destroyed at mitosis exit by ubiquitin-mediated mechanism (catalyzed by the APC/C)
Anaphase-Promoting Complex (APC, cyclosome, APC/C)
- degrades the mitotic (B) cyclins
- triggers the events leading to destruction of the cohesins
- allowing the sister chromatids to separate
Links: MBC Figure 13-2. Current model for regulation of the eukaryotic cell cycle | control of proteolysis by SCF and APC during the cell cycle
Cyclin-dependent Kinases
- Inactive until bound to a specific cyclin
- kinase - means an enzyme which phosphorylates a target protein(s)
- Drive M to S Phase
- cdk1 and cdk2
- Cdk1 activated at G2 to M
- Cdk2 activated at G1 to S
Movie CDK/Cyclin: Cell-Cycle Control
Cell Cyclin Changes
Interphase and M Phase
- Division controlled by synthesis/degradation cyclin B
- regulatory subunit of Cdc2 protein kinase
- interphase cyclin B synthesis leads to formation of active cyclin B–Cdc2 complex
- induces entry into mitosis
Rapid degradation of cyclin B leads to inactivation Cdc2 kinase
- Allow cell to exit mitosis and return to interphase next cell cycle
- cyclin B-CDC2 acts as M phase-promoting factor (MPF)
- activate other proteins through phosphorylation
- cyclin A down-regulation induces a G2 phase arrest through a checkpoint-independent inactivation of cyclin B-CDC2 by inhibitory phosphorylation.
- cyclin A cannot form MPF independent of cyclin B
Regulator Checkpoints
These regulators are often described as "tumor suppressor proteins" due to their ability to block tumor (cancer) growth. Conversely, mutations in these genes often lead to tumor growth.
Checkpoints in the cell-cycle control system
How DNA damage arrests the cell cycle in G1
- (TP53) A multifunctional protein Mr 53 kDa regulating cell cycle and apoptosis
- As a cell cycle regulator it recognizes and binds damaged DNA
- single-stranded DNA, insertion/deletion mismatches, and free DNA ends
- Acts as a transcription factor activating p21 transcription
- p21 protein then inhibits G1 cyclin-dependent kinases p21
p53-induced cell-cycle arrest in response to DNA damage
unstressed cells
- p53 levels are low through a continuous degradation
- Mdm2 (HDM2 in humans)
- binds p53
- blocks action
- transports p53 from nucleus to the cytosol
- gene has been shown to be damaged in cells by mutagens
- mutations found with
- Li-Fraumeni syndrome OMIM 151623
Effect of mutation of the p53 tumorsuppressor gene on G1 DNA-damage checkpoint control
Science magazine designated p53 the 'Molecule of the Year' for 1993
- retinoblastoma protein regulating cell cycle
- As a cell cycle regulator it recognizes damaged DNA
- binds and inhibits transcription factors of the E2F family
- active pRb is hypophosphorylated
- inactive pRb is phosphorylated
- mutations in this gene lead to the disease retinoblastoma OMIM 180200
- also called Cyclin-dependent kinase inhibitor 2A
- blocks activation of Cyclin E gene
- mutations found with
- pancreatic adenocarcinoma OMIM 260350
- esophageal and gastric cancer cell lines
MH - There are many detailed resources on oncogenesis (cancer) this is only a brief mention in regard to cell cycle. See also the tumor suppressor section above. An importanrt issue is the concept of "multiple hits".
- some viruses can infect human cells and lead to oncogenesis (cervical cancer, liver cancer, and certain lymphomas, leukemias, and sarcomas)
- for example - human papillomavirus (HPV)
Essential Cell Biology
- Essential Cell Biology Chapter 17
Molecular Biology of the Cell
Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002
- Molecular Biology of the Cell 4th ed. - IV. Internal Organization of the Cell Chapter 17. The Cell Cycle and Programmed Cell Death
- An Overview of the Cell Cycle
- Figure 17-1. The cell cycle
- The Cell Cycle and Programmed Cell Death
Molecular Cell Biology
Lodish, Harvey; Berk, Arnold; Zipursky, S. Lawrence; Matsudaira, Paul; Baltimore, David; Darnell, James E. New York: W. H. Freeman & Co.; c1999
- Molecular Cell Biology - Chapter 13. Regulation of the Eukaryotic Cell Cycle
- Regulation of the Eukaryotic Cell Cycle
- Overview of the Cell Cycle and Its Control
- Figure 13-2. Current model for regulation of the eukaryotic cell cycle
- Movie: Cell Cycle Control
The Cell- A Molecular Approach
Cooper, Geoffrey M. Sunderland (MA): Sinauer Associates, Inc.; c2000
- The Cell - A Molecular Approach - IV. Cell Regulation Chapter 14. The Cell Cycle
- The Eukaryotic Cell Cycle
- Figure 14.1. Phases of the cell cycle
Search Online Textbooks
- "cell cycle" Molecular Biology of the Cell | Molecular Cell Biology | The Cell- A molecular Approach | Bookshelf
- "cyclin" Molecular Biology of the Cell | Molecular Cell Biology | The Cell- A molecular Approach | Bookshelf
- PubMed is a service of the U.S. National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals for biomedical articles back to 1948. PubMed includes links to full text articles and other related resources. PubMed
- PubMed Central (PMC) is a free digital archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health (NIH) in the National Library of Medicine (NLM) allowing all users free access to the material in PubMed Central. PMC
- Online Mendelian Inheritance in Man (OMIM) is a comprehensive compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM
- Entrez is the integrated, text-based search and retrieval system used at NCBI for the major databases, including PubMed, Nucleotide and Protein Sequences, Protein Structures, Complete Genomes, Taxonomy, and others Entrez
Search Pubmed
- "cell cycle" Entrez all databases
- "cyclin" Entrez all databases
- "cyclin dependent kinase" Entrez all databases
- "p53" Entrez all databases
- "pRb" Entrez all databases
- The great divide: coordinating cell cycle events during bacterial growth and division. Haeusser DP, Levin PA. Curr Opin Microbiol. 2008 Apr;11(2):94-9. Epub 2008 Apr 7. Review. PMID: 18396093 | PMC
- Cell cycle studies based upon quantitative image analysis. Stacey DW, Hitomi M. Cytometry A. 2008 Apr;73(4):270-8. Review. PMID: 18163464
- Analysis of cell cycle phases and progression in cultured mammalian cells. Schorl C, Sedivy JM. Methods. 2007 Feb;41(2):143-50. Review. PMID: 17189856
- Cell cycle regulation of DNA replication. Sclafani RA, Holzen TM. Annu Rev Genet. 2007;41:237-80. Review. PMID: 17630848
External Links
- Fzy and Fzr cooperate to destroy cyclin B in flies Raff et al. examine two regulators of fly cyclin B destruction: Fizzy (Fzy)/Cdc20 and Fzy-related (Fzr)/Cdh1. Fzy/Cdc20 is concentrated at kinetochores and centrosomes early in mitosis, whereas Fzr/Cdh1 is concentrated at centrosomes throughout the cell cycle. In syncytial embryos, only Fzy/Cdc20 is present, and only the spindle-associated cyclin B is degraded at the end of mitosis. A mutant form of cyclin B that cannot be targeted for destruction by Fzy/Cdc20 is no longer degraded on spindles of syncytial embryos, but still targeted by Fzr/Cdh1 in cellularized embryos, albeit more slowly than normal. This suggest that Fzy/Cdc20 is responsible for catalyzing the first phase of cyclin B destruction that occurs on the mitotic spindle, whereas Fzr/Cdh1 is responsible for catalyzing the second phase of cyclin B destruction that occurs throughout the cell.
2010 Course Content
Lectures: Cell Biology Introduction | Cells Eukaryotes and Prokaryotes | Cell Membranes and Compartments | Cell Nucleus | Cell Export - Exocytosis | Cell Import - Endocytosis | Cell Mitochondria | Cell Junctions | Cytoskeleton Introduction | Cytoskeleton 1 Intermediate Filaments | Cytoskeleton 2 Microtubules | Cytoskeleton 3 Microfilaments | Extracellular Matrix 1 | Extracellular Matrix 2 | Cell Cycle | Cell Division | Cell Death 1 | Cell Death 2 | Signal 1 | Signal 2 | Stem Cells 1 | Stem Cells 2 | Development | Revision
Laboratories: Introduction to Lab | Microscopy Methods | Preparation/Fixation | Immunochemistry | Cell Knockout Methods | Cytoskeleton Exercise | Confocal Microscopy | Microarray Visit | Tissue Culture 1 | Tissue Culture 2 | Stem Cells Lab | Stem Cells Analysis
Dr Mark Hill 2015, UNSW Cell Biology - UNSW CRICOS Provider Code No. 00098G


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Academic Policy Details
Academic Expectations
Students entering William Woods University should be prepared for a considerable amount of work outside the classroom. These requirements differ from class to class from discipline to discipline, but most instructors expect two hours of out-of-class work for each course credit hour. All instructors expect their students to be prepared for class.
These policies apply to the Semester Program/On Campus students only. Graduate College Students will need to consult the Graduate College Bulletin.


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Fighting Force 2 (Playstation) (Pre-Played - Game Only)
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Heritage Harvest Festival at Monticello
Visitors are invited to celebrate the legacy of revolutionary gardener Thomas Jefferson during the annual Heritage Harvest Festival at Monticello. Thomas Jefferson, America's "first foodie," championed vegetable cuisine, plant experimentation, and sustainable agriculture. Taste a bounty of heirloom fruits and vegetables and learn about organic gardening and seed-saving during this fun, affordable, family-friendly festival unlike any other—held on the breathtaking West Lawn of Jefferson's Monticello and the new Thomas Jefferson Visitor Center. The event includes a hundred educational programs, hands-on workshops, garden tours, an organic, local food marketplace, a seed swap, music, and more. 931 Thomas Jefferson Parkway (Rt. 53). 984-9809.Read more on: heritage harvest festivalkids and familymonticello


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Bradley Manning acquitted of aiding the enemy for giving secrets to WikiLeaks
Updated 7:26 p.m. ET
Bradley Manning, the 25-year-old Army private who gave thousands of classified U.S. military and diplomatic documents to WikiLeaks, was acquitted of aiding the enemy in a military court-martial, but was convicted on multiple other counts.
As CBS News correspondent David Martin reported, Manning had chosen to have his fate decided by a judge, Army Col. Denise Lind, rather than a military jury. Col. Lind gave no explanation for her verdict or why she was not convinced by the government's contention that manning knew the material he provided to WikiLeaks would make its way to the enemy.
The charge of aiding the enemy was the most serious of 21 counts. It carried a possible life sentence without parole.
Manning was convicted of six espionage counts, five theft charges, a computer fraud charge and other military infractions. Manning's sentencing hearing is set to begin Wednesday.
Manning pleaded guilty earlier this year to reduced versions of some charges. He faces up to 20 years in prison for those offenses, but prosecutors pressed ahead with the original eight federal Espionage Act violations, five federal theft counts, and two federal Computer Fraud and Abuse Act violations, each punishable by up to 10 years; and five military counts of violating a lawful general regulation, punishable by up to two years each. All told, Manning faces a maximum of up to 136 years in prison for his various convictions. There is, however, no minimum sentencing requirements for Judge Lind to follow.
According to the Associated Press, Manning did not appear to react to the verdict, although his attorney, David Coombs, smiled faintly when he heard not guilty on aiding the enemy.
"We won the battle, now we need to go win the war," Coombs said outside the courtroom after the verdict Wednesday. "Today is a good day, but Bradley is by no means out of the fire."
Manning, a native of Crescent, Okla., had prior to the verdict admitted to sending 470,000 Iraq and Afghanistan battlefield reports, 250,000 State Department diplomatic cables and other material, including several battlefield video clips, to WikiLeaks while working in Army intelligence in Iraq in early 2010.
WikiLeaks published much of the material on its website, as well as in cooperation with several news outlets like The New York Times and The Guardian.
Prosecutors had argued that Manning had a "general evil intent" because he knew the classified material would be seen by and help terrorists. They claimed when Navy SEALs raided Osama bin Laden's Pakistani compound in 2011, they found copies of WikiLeaks documents that Manning had provided. Prosecutors also argued that Manning simply wanted to make a name for himself by leaking the classified material.
Manning himself did not testify during the trial, but in a pre-trial hearing said he wanted to expose what he called the American military's "bloodlust" and disregard for human life in Iraq and Afghanistan, as well as its dishonest diplomacy, and that he carefully selected material that wouldn't put troops in harms' way. His attorney has tried to portray Manning as a whistleblower with good intentions.
Reactions to the Manning verdict have been mostly positive out of Washington D.C.
Rep. Mike Rogers, R-Mich., and Rep. Dutch Ruppersberger, both members of the House Intelligence Committee, released a joint statement after the verdict hailing the multiple convictions.
"Justice has been served today," the statement read. "PFC Manning harmed our national security, violated the public's trust, and now stands convicted of multiple serious crimes. There is still much work to be done to reduce the ability of criminals like Bradley Manning and Edward Snowden to harm our national security."
Manning's supporters, however, were dismayed by Tuesday's verdict. WikiLeaks said on its official twitter feed the conviction on espionage charges was "dangerous national security extremism from the Obama administration."
Following Tuesday's espionage conviction WikiLeaks's founder, Julian Assange, said the conviction against a whistleblower was "dangerous precedent."
"Bradley Manning's alleged disclosures have exposed war crimes, sparked revolutions, and induced democratic reform," said Assange in a statement. "He is the quintessential whistleblower.
"This is the first ever espionage conviction against a whistleblower. It is a dangerous precedent and an example of national security extremism. It is a short sighted judgment that can not be tolerated and must be reversed. It can never be that conveying true information to the public is 'espionage.'"
Many legal analysts said earlier that a conviction of Manning would mark a new precedent in prosecutions of U.S. secret leakers because the Army private never actually shared the information directly to an enemy of the U.S.
"Most of the aiding-the-enemy charges historically have had to do with POWs who gave information to the Japanese during World War II, or to Chinese communists during Korea, or during the Vietnam War," Duke law school professor and former Air Force judge advocate Scott Silliman told the Associated Press.
Manning's supporters have expressed fears that this new turn in leak prosecutions will have a chilling effect on potential whistleblowers of government wrongdoing.
The actual effects of Manning's leaks are still being debated three years later.
One of the videos leaked by Manning included a 2007 U.S. Apache helicopter attack in Baghdad that killed at least nine men, including a Reuters news photographer and his driver. The video inflamed anger among many in the both the U.S. and abroad, because it allegedly showed unarmed civilians being killed, something the U.S. military disputed was incorrectly portrayed due to editing.
Other material leaked by Manning included thousands of confidential diplomatic cables that revealed the frank and often embarrassing discussions America's diplomatic corps had about various world leaders and geopolitics. For a time, there was anger amongst foreign diplomats and governments about some of the exposed secrets, but three years on, the latest series of U.S. government leaks produced by former NSA contractor Edward Snowden have received nearly all of the international outrage towards America's clandestine behavior and actions. An example of one of the many revelations Manning leaked was a diplomatic cable claiming Saudi Arabia -- a key regional ally for the U.S. -- is one of the largest origin points for funds supporting international terrorism.
From the documents Manning leaked that came from the Pentagon, one of the many revelations was that there were 109,032 "violent deaths" recorded in Iraq between 2004 and 2009, including 66,081 civilians, which is 15,000 more than previously reported.


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EDMONTON - Bill Minhas has lived in Fort McMurray for 27 years and raised his family in the northern Alberta community.
But he hasn't driven down Highway 63 since last Nov. 14, when his uncle, Ranjit Doad, was killed in a head-on crash on his way home to Calgary.
"It scared the hell out of me," said Minhas, 55, who gathered with a crowd of about 500 Saturday at MacDonald Island Park in Fort McMurray to demand the province immediately twin Highway 63.
Minhas carried a sign with his uncle's name on it and used the protest, called Twin63Now, as a way to mourn with others affected by the growing death toll on the mainly two-lane road.
The protest was organized through social media after seven people, including two children and a woman who was six months pregnant, died April 27 in a fiery head-on crash.
Since 2006, 46 people have died on the highway, which connects Edmonton to Fort McMurray.
Minhas said his uncle had just retired at age 60, but was working as a contractor to keep himself busy. Now, Minhas, who works as a training manager at Suncor, can't imagine his own retirement.
"I was hoping for a good ending, retiring in a couple of years, but then this happened," Minhas said, noting that investigators are still trying to determine the cause of his uncle's crash with a one-tonne truck.
The roads were clear, it was daylight and his uncle was alert, having slept in Fort McMurray overnight instead of heading out directly after his shift.
"He was my big brother. I followed him along to Canada (from India). I followed him to Fort McMurray. I used to see him every day … Acceptance is the hardest thing."
Minhas said he cried during the protest, embracing and consoling another family whose 16-year-old son was also killed on the road.
"It was a nice feeling that the community cares for people," Minhas said. "I hope this is an excellent start (for change)."
Nicole Auser, who organized the demonstration with Ashley St. Croix, said people are desperately pleading for the highway to be twinned.
"The community is crying for someone to hear them on this Highway 63 issue." John Matthews, a folksinger from Australia who has worked in Fort McMurray as an engineer for nine years, said people wept as he sang a tribute song, but also rallied around the chorus, chanting, "Cry out, at the shame. Cry out, who's to blame."
"Everybody seemed to know somebody who has suffered a loss or had some very bad experiences on that highway," said Matthews, 57.
"At times it felt like it was a memorial and at times it felt like a public outcry to move forward … People were acting out of frustration of not being able to resolve something that seems so straightforward. Twinning the highway is the focus, but the absolute end game is to minimize the fatalities."
Matthews said the construction work has to be accompanied by a cultural shift to embrace safe driving and additional training when needed.
"There's no place where you can marginalize people who have bad social driving behaviour."
He wants more signs along the road reminding people to take care and wake up. More rest stops are also needed, because there are few places to sip coffee or stretch.
"Maybe (we also need) some tolerance of working people by industry saying, 'I'd rather my employee was two hours late in the morning (than arrive speeding).' "
A convoy of buses from Diversified Transportation, where crash victim Courtney Penney worked, shuttled transportation-company staff and other passengers to the rally, said the firm's contract manager Anne Kendall.
Eight buses representing the victims who died in the April 27 crash, including Penney's unborn child, made a seven-kilometre trip to MacDonald Island Park that included a section of Highway 63.
"Our drivers are affected daily by what happens on Highway 63, both north and south of the city … so it's a way of them showing their support, and the company donating the buses was their way of saying we support our employees," Kendall said.
Roughly 19 kilometres of the highway south of Fort McMurray has already been twinned, while the province hopes to have a 36-kilometre section north of Wandering River paved by fall 2013.
That leaves 185 kilometres to be twinned, a project expected to cost at least $1 billion.
Premier Alison Redford said this week that completing the work is one of her priorities.


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Processing time
2-4 business days
Customs and import taxes
Buyers are responsible for any customs and import taxes that may apply. I'm not responsible for delays due to customs.
This is a beautiful, handcrafted Artisan ring made in my small shop in Stittsville, Ontario, in Canada. Smoked Eucalyptus is a gorgeous, exotic wood with a very dark, almost black colouration that polishes to a high shine. This option features a beautiful Carmine opal inlay. Each ring is sealed and finished to a high polish. This ring is offered on a titanium comfort fit core in widths of 6mm, 8mm, and 10mm, but please ask about additional custom ring core options. US full and half ring sizes from 6 - 12 are available. If you require a custom order at a different size, please send me a message and I will do my best to accommodate. These rings are made using the Bentwood technique. This method of wrapping several layers of stabilised wood veneer around the core results in a stronger, more beautiful ring than those simply cut from blocks.
Shown in 6mm comfort fit width.
Please be certain to have your ring size checked professionally by a jeweler (usually a complimentary service) to ensure that you will have an accurate fit. To avoid any issues with the sizing, it is strongly advised not to use unreliable methods such as an online printable ring sizer or measuring by wrapping a string around your finger. My bentwood rings are sized per the US standard ring sizing specifications and will be double-checked prior to shipping. If the wrong size is ordered by mistake, there will be fees to build a replacement ring. I will work with the customer to find a solution, but accurate sizing is the sole responsibility of the buyer. Exchange fees due to incorrect sizing will be a flat rate of 40%** of the regular (non-sale) price of the ring, plus separate shipping (typically $15 to Canada and the USA). Higher shipping costs will apply to international destinations. In addition, the original ring must be returned in "as new" condition. Please note as well that wider cores (e.g. 9mm-10 mm) will typically fit a little more snugly than narrower widths, such as 6 mm. Please consider going up a half size for this wider option.
**Note that dual bentwood designs (bentwood wood outer and inner cores) will incur fees of 50% of the original price of the ring, plus the shipping charges stated above.
Please note that I now sell plastic ring sizers at cost that work quite well.
The wood is well stabilised, but it is advised to avoid prolonged submersion in water, such as for bathing, swimming, or doing dishes. The ring will last many years if cared for properly. An occasional light buffing with wood appropriate polish will keep your handmade ring looking great. Please avoid harsh abrasives.
1. A made-for-you bentwood ring in your choice of several exotic wood options, sizes, and widths.
2. A custom, laser engraved wood ring box.
2-4 business days
Buyers are responsible for any customs and import taxes that may apply. I'm not responsible for delays due to customs.
Just contact me within: 3 days of delivery
Ship items back to me within: 21 days of delivery
Request a cancellation within: 12 hours of purchase
But please contact me if you have any problems with your order.
Because of the nature of these items, unless they arrive damaged or defective, I can't accept returns for:
Buyers are responsible for return shipping costs. If the item is not returned in its original condition, the buyer is responsible for any loss in value.


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Important information
The Important Information and Terms of Use will be periodically updated. Schroders plc is the holding company of the Schroder Group of companies. For more information about the Group, please visit the About Schroders web pages at www.schroders.com.
Schroder & Co. Limited
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The contents of this website are communicated by Schroder & Co. Ltd which is authorised by the Prudential Regulation Authority and regulated by the Financial Conduct Authority and the Prudential Regulation Authority. Schroder & Co. Ltd is entered on the FCA register under the following register number: 144206.
Registered Office
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Registered number: 2280926
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The content of the web pages to which this statement is linked (the "Linked Pages") should be construed under and governed by the laws of England and Wales save where such content is expressed to be governed by the laws of another jurisdiction. By accessing the web pages you agree to submit to the exclusive jurisdiction of the Courts of England and any adjudication they make in respect of litigation arising in connection with the web pages. Information provided to Schroders plc by you will be processed for the purposes for which it was furnished and may be shared with companies in the Schroder Group in the UK and internationally. For your security communications may be taped or monitored. Products or services mentioned on this site are subject to legal and regulatory requirements in applicable jurisdictions and may not be available in all jurisdictions. This site is not directed to nor intended for distribution or use in any jurisdiction where such distribution or use would be contrary to the laws of such jurisdiction or regulation. In accessing this site, it is your responsibility to comply with applicable local, national and international laws. Please read the general Terms of Use applicable to Schroder Group web sites. If you have any comments or want to provide feedback about this web site please send an email to firstname.lastname@example.com
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Exchange Tower
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On this web site you may be offered automatic links to other sites which we hope you will be interested in. Schroders does not accept any responsibility for the content of those web sites, the owners of which do not necessarily have any link, commercial or otherwise, with Schroders. As you navigate between different pages on Schroders' web sites you will interact with different entities in the Schroder Group. The specific entity responsible for the content of a web page is clearly shown on each web page. The Important Information section is different for each of these entities.


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Guiness Cake with Irish Cream Frosting
I recently found the perfect St. Patrick's Day dessert while perusing Pinterest. I can't wait to give it a try this year. It combines the best of both Worlds, chocolate and beer. If that's not enough, the frosting to top this delicious cake is Irish cream flavored too. I'm pretty sure that dessert doesn't get much more Irish, or delicious, than this.
Guiness Chocolate Cake
1 box chocolate cake mix
1 bottle of Guiness
Rest of ingredients needed to make a boxed cake of your choice
Make cake as the box calls for, except substitute the amount of water you would add to the mix with the same amount of Guiness. Bake the cake as directed and let cool.
Irish Cream Frosting
4 ounces soft cream cheese
1 cup powdered sugar
3 tablespoons Irish cream
Whip the cream cheese and then slowly add the powdered sugar. Once the powdered sugar is all mixed in, slowly add the Irish cream. Now use your frosting to frost your cake.
Joy Larson is a mother of four boys, graduate of The University of Montana, animal lover and writer.


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SearchSkip to Search Results
- 2Chakrabarti, Subhadeep
- 2Davidge, Sandra T.
- 2Kaufman, Susan
- 2Majumder, Kaustav
- 2Morton, Jude S.
- 2Panahi, Sareh
Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive ratsDownload
Majumder, Kaustav, Kaufman, Susan, Chakrabarti, Subhadeep, Morton, Jude S., Panahi, Sareh, Wu, Jianping, Davidge, Sandra T.
Background There is a growing interest in using functional food components as therapy for cardiovascular diseases such as hypertension. We have previously characterized a tri-peptide IRW (Ile-Arg-Trp) from egg white protein ovotransferrin; this peptide showed anti-inflammatory, anti-oxidant and...
Beneficial effects of simulated gastro-intestinal digests of fried egg and its fractions on blood pressure, plasma lipids and oxidative stress in spontaneously hypertensive ratsDownload
Majumder, Kaustav, Jahandideh, Forough, Morton, Jude S., Davidge, Sandra T., Kaufman, Susan, Chakrabarti, Subhadeep, Panahi, Sareh, Wu, Jianping
Background We have previously characterized several antihypertensive peptides in simulated digests of cooked eggs and showed blood pressure lowering property of fried whole egg digest. However, the long-term effects of this hydrolysate and its fractions on blood pressure are not known. Therefore,...


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Last week, T-Mobile announced the price and availablity of the powerful HTC One S smartphone. This handset was announced and showcased at the Mobile World Congress (MWC) 2012 in Barcelona. It is the company's first smartphone which runs on the latest Android 4.0 (Ice Cream Sandwich) Operating System. T-Mobile finally released the device exclusively for its subscribers in the US. If you are still unaware of the features, then you can check out the complete specs after the break.
HTC One S features a 4.3 inch Super AMOLED display, sporting a resolution of 960 x 540 pixels, 1.5 GHz Snapdragon S4 dual-core processor, Android 4.0 (Ice Cream Sandwich) OS, HTC Sense 4.0, 8 megapixel autofocus camera with LED flash, full HD (1080p) video recording and playback, VGA front-facing camera and so on.
Other features include a 3.5 mm headset jack, Stereo FM radio with RDS, WiFi 802.11 b/g/n, 4G Connectivity, 1 GB RAM, 16 GB internal memory, Bluetooth 4.0 with A2DP, microUSB 2.0, A-GPS, Play Store, 25 GB DropBox cloud storage, DLNA, Wi-Fi hotspot capabilities, Beats Audio and a 1650 mAh battery.
The HTC One S is currently available for $199.99 with a 2 year service agreement and a $50 mail-in rebate. You can also get this device without any contract for $599.99. Are you planning to buy this handset or you will wait for the AT&T HTC One X and the upcoming Samsung Galaxy S III. Do let us know your views in the comments section below.


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Joan Blondell goes to the chair — fer poimanent!
Sorry, that shouled have read "Joan Blondell sits in a chair for a permanent."
Ina Claire, left, costumed by Coco Chanel.
Film: THREE BROADWAY GIRLS, AKA THE GREEKS HAVE A WORD FOR THEM. Apparently Goldwyn insisted on changing the play's title from The Greeks Have a Word for It, further proof of his lack of taste and sense in my opinion. And then i guess the film didn't do so well so they went for a blander title.
Smashing pre-code Goldwyn! The original of HOW TO MARRY A MILLIONAIRE, great performances by Claire and Blondell, decent support from Madge Evans, that oddly appealing drip David Manners, and suaveness machine Lowell Sherman, who also directed. Lots of spicy and amoral content, including Ina discarding her garb for an unparalleled fur-coat-and-no-knickers scene. Some combination of the Goldwyn quest for "quality" (that drab chimera), the theatrical origins, the limitations of '30s technique, and Sherman's direction, makes the film just a little stiffer than the very best pre-codes, but it benefits from the ability of the characters to constantly surprise us by stepping outside the norms of behaviour later enforced by censorship. Like so ~


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|Student type
|Fees to pay
|UK students
|EU students
|International students
Medway Valley Training Partnership
Religious Education (2SCQ)
PGCE with QTS full time
- Accredited body
- Kent and Medway Training
- Financial support
- Bursary or student finance if you're eligible
- Qualification
PGCE with QTS
A postgraduate certificate in education (PGCE) with qualified teacher status (QTS) will allow you to teach in state schools in England and may allow you to teach in other parts of the UK.
It may also allow you to teach overseas, though you should always check what qualifications are needed in the country you'd like to teach in.
Many PGCE courses include credits that count toward a Master's degree.
- Course length
- 1 year
- Date you can apply from
- 8 October 2019
- Date course starts
- September 2020
- Website
- http://www.mvtp.org
- About the course
- Interview process
- How school placements work
- Fees
- Financial support
- Requirements
- About the training provider
- Training with disabilities and other needs
- Contact details
- Apply
- Support and advice
About the course
The training year commences at the beginning of the academic year through to middle of June the following year enabling you to take up employment from 1st July to schools that offer it. This practical course comprises a mix of classroom-based teaching in a school to academic training on either generic "Professional Studies" lectures at a local KMT hub-training centre or "Subject Studies" training with the other RE trainees at various locations across the partnership.
For the first two placements, you work in school for 4 days a week learning how to teach by leading lessons. Thursday is your academic afternoon where either professional or subject studies sessions take place. When you return to you home school after Easter, you will be in school for the full 5 day week.
Your studies gradually build from observing teachers and lessons to working with your mentor in team planning and teaching until by the end of the course, you are teaching 60% of a full timetable. At all times, there will be the classroom teacher available to support you nearby.
You will gain experience of parents evenings, clubs and many other after school events that make up the life of a teacher.
The course focuses on the teaching and learning of KS3 and KS4 students and you will be assessed on your teaching of classes from these key stages. However, because of Kent and Medway's unique education system you will also be given the opportunity to experience KS5 teaching.
Throughout the year, you will be building up a portfolio of evidence demonstrating your progress towards meeting the "Teaching Standards." Academic research is through the completion of Reflective, Practical Journals (RPJ) and these are spread across the academic year.
In addition, for those wishing to top up their qualification to PGCE, you will have other assignment to complete at various times through the year as published by the University of Leeds Beckett. This course is delivered through a distance-learning package and training will take place in your local hub- training centre.
To aid your development, you will have one formal lesson observation and one dedicated mentor meeting each week. This is where you sit with your school mentor, discuss your progress and make targets for the following week. Their work is enhanced further by KMT lead mentors and course directors who further oversee and support all aspects of your studies.
Interview process
To be considered for interview, we need a completed UCAS application. To avoid delay we accept emailed drafts of these (pending references) emailed to email@example.com .
Once received, your application is sent to your chosen campus for their consideration.
If selected for interview, a date will be arranged where you will;
visit the school,
observe and participate in lessons,
sit the KMT entrance tests in English and RE
undertake a formal interview with the Subject Leader. the school's Professional Tutor and a representative from Kent and Medway Training.
PLEASE NOTE: We never ask applicants on a non-salaried course to teach a lesson or part lesson at interview.
The formal interview is approximately 50 minutes long. You will be required to prepare a 10-minute presentation on what made a lesson that you have seen, good or not so good. Further questions are asked to ascertain your suitability for teaching.
You will be given a conditional offer only if all members of the panel agree to the placement. However, should you impress at interview but not be offered a place, you will be given the opportunity for your application to be considered by other partner schools without the need to sit a second formal interview. Under these circumstances. you will visit the school, meet the Professional Tutor and Subject Leader, observe lessons and if all goes well, a conditional offer is made.
How school placements work
All applicants have the opportunity at application, to apply for the school of their choice. If appointed, that school becomes the trainee's "home" school and is responsible for the majority of the training; subject to the course requirements and quality assurance of the accrediting provider, Kent and Medway Training. The training year is split into three placements:
Placement A is at your home school and runs from the beginning of the academic year until the end of January. You are in school for four days a week learning how to teach your subject through a mixture of practical classroom experience and school-led training sessions. Thursdays are your KMT academic days where you will have either Professional Studies, led by experienced practitioners or Subject Studies training, led by subject specialists.
Placement B is at a contrasting school. For example, if your home school is a High School, you B-placement could be a Grammar School. Where possible, your B-placement school will be discussed with you in advance and you will be placed in the local Medway or Maidstone area.
The placements runs from February to Easter where you continue to improve your teaching skills through teaching classes to school-led training sessions. Thursdays remain your KMT academic days where you continue with Professional Studies, led by experienced practitioners or Subject Studies training, led by subject specialists.
- Placement A2 is back at your home school where you remain from Easter until the completion of your course in June. You will be in school for the full 5-day week. Thursday Professional and Subjects studies will have finished except for one further evening session preparing you for your Newly Qualified Teacher year.
During this placement you will be finally assessed through both lesson observation and your completed portfolio to ensure that you have met the teaching standards in full. Our grades are then externally moderated and assuming all goes well, your Newly Qualified Teacher status is confirmed and celebrated at a local hub- centred Awards Evening.
The fee of £7100 is the cost for all trainees leading to Qualified Teacher Status (QTS) only. This fee is payable by all non-salaried trainees but payable by the home school for salaried trainees.
For those wishing to "top up" their qualification to the full Post Graduate Certificate in Education (PGCE) a further £1800* will be payable to the University of Leeds Beckett who are our PGCE accredited body. This fee is payable by both salaried and non-salaried trainees.
- This is correct at the time of publication but is subject to change.
Financial support
You'll get a bursary of £9,000 if you have a degree of 2:2 or above in any subject.
You don't have to apply for a bursary - if you're eligible, you'll automatically start receiving it once you begin your course. Find out about eligibility and how you'll be paid.
You may be eligible for a loan while you study – note that you'll have to apply for undergraduate student finance.
Find out about financial support if you're from outside the UK.
-An Honours degree of 2:2 or better preferably in the Subject specialist area in which you are to train. -GCSE Maths pass of Grade C/ Level 4 or better. -GCSE English pass of Grade C/ Level 4 or better. -Skills Test pass in Numeracy. -Skills Test pass in Literacy.
-For those with overseas qualifications, we will need to see confirmation from NARIC of your qualifications being the equivalent of UK degree and GCSEs.
Personal qualities
- Strong and dedicated professionals
- Resilient
- Proactive and creative
- Open to feedback and guidance
- Passionate about developing pupil learning and well being
- Strong in their subject knowledge
- Positive in their communication skills
- Genuinely aiming to become an outstanding practitioner
- Enjoy working with children and young adults
Other requirements
Before the course begins but not necessarily at application, you will need
- at least 10 experience days in a secondary school or academy
- at least 2 experience days in a primary school or academy
- DBS check
- Health check declaration
It is useful to attend a school experience day before application so that you can get a feel for the chosen school and what it can offer as a training placement.
About the training provider
The Medway Valley Training Partnership (MVTP) comprises schools and academies from Primary to Secondary level. MVTP co-ordinate the recruitment of trainee teachers onto suitable SCHOOL DIRECT teacher training programmes for our partner schools. Due to our success, we have grown tremendously from our small partnership of five schools, three years ago to a partnership of fifteen and counting.
You will find our schools in both Medway Towns and Maidstone areas in Kent, linked by the pretty "Medway Valley" railway branch line which runs from Strood station through to Maidstone West and beyond.
We offer a range of specialist secondary teacher-training courses alongside primary in a variety of school settings that will equip the successful trainee with the skills to be able to confidently teach anywhere in the country. Our unique position in Kent means that, where possible, trainees will experience not just Key Stage 3 and 4 GCSE training but also Key Stage 5, A -level. All of our School Direct teacher training courses are available at both Qualified Teacher Status (QTS) and Post- Graduate Certificate of Education (PGCE).
We have an excellent success rate with 100% of trainees completing the training course now employed in a school with over 90% in their home school or one of KMT's other partnership schools or academies.
All MVTP schools share one common goal;
About the accredited body
Kent and Medway Training (KMT) is a highly regarded and successful Schools Centred Initial Teacher Training Provider (SCITT) which has been successfully training teachers for over 25 years. With School Direct our reputation has seen us grow tremendously from training 40 students a year to over 170 across our partnership of 70 schools. KMT offer training which leads to Qualified Teacher Status (QTS) and our partnership arrangement with The University of Leeds Beckett gives our trainees the opportunity to access a PGCE Top-Up qualification while they train or in the first two years of teaching. This offers Masters Level credits.
Training with disabilities and other needs
We welcome applications from those with disabilities and regularly train and support students with dyslexia and mental health problems.
We, with our accreditation partners Kent and Medway Training, offer support and help with passing the Literacy and Numeracy Skills tests. We teach strategies for ensuing that Spelling, Punctuation and Grammar are accurate in, especially, work that is handed out to school pupils.
We have introduced a programme of support for those with mental health conditions and further advice as to where to gain specialist support should you need it.
We are proud of the support and guidance that we give to ensure that you are able to give of your best during your training year and we provide an environment in which you can feel comfortable in seeking support should you need it.
MVTP now have two secondary schools within our partnership that have specialist visually and hearing impairment centres:- Thomas Aveling for hearing and Robert Napier for Visual impairment.
Contact details
- firstname.lastname@example.com
- Telephone
- 01634 408425
- Website
- http://www.mvtp.org
- Address
c/o The Thomas Aveling School
Arethusa Road
Support and advice
For questions about this course you should contact the training provider using the contact details above.
Get support and advice about teaching
Register with Get Into Teaching, the Department for Education's free support and advice service, for personalised guidance from teaching experts. They can help you to prepare your application, book school experience, and access exclusive teaching events. You can also call them free of charge on 0800 389 2500, or speak to an adviser using their online chat service, from 8am to 8pm, Monday to Friday.
Website support
If you have feedback or have had a problem using Find postgraduate teacher training you can contact us by email.
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If there is something wrong with this course listing, contact us by email.


text:
Audit and Accounts Semi Senior - Top 20 Chartered Accountants
- Recruiter
- Michael Page
- Location
- Kent, Maidstone
- Salary
- £25000 - £35000 per annum + Benefits
- Posted
- 22 Mar 2019
- Closes
- 22 Apr 2019
- Ref
- 13947308/001
- Contact
- Tristan Finch
- Job role
- Accountant, Audit
- Sector
- Accounting - Public practice
- Contract type
- Permanent
- Hours
- Part time
An amazing opportunity for a part qualified or nearly qualified ACA or ACCA Audit and Accounts Semi Senior, to join a highly reputable firm of chartered accountants in a role with genuine progression and development potential with exposure to some of the most sought after clients in the South East.
Client Details
A fantastic, national Top 20 chartered accountancy practice based near Maidstone with an exceptional reputation. They provide a wider array of services including accounts, tax, audit, bookkeeping, payroll and a wide array of advisory services.
- Conduct audits, primarily out of the office
- Produce audit files for review
- Carry out review work on audits and accounts jobs prepared by colleagues
- Act as mentor for junior team members and provide day to day training
- Supervise junior team members in the office and at clients' premises and provide assistance as required
- Conduct assignment and performance reviews
- Anticipate and overcome difficulties on audits and larger accounts jobs
- Build and maintain successful relationships with clients
- Identify and suggest improvements to audit and accounting processes
The ideal Audit and accounts Semi Senior will be a well-organised and self-motivated professional team player, with good communication skills with the ability to work well under pressure. With an analytical mind, you will already have a good grasp of technical accounts or audit issues and able to manage your own time and budgets.
As a part qualified AAT/ ACA/ACCA Semi Senior (or finalist), you'll be confident with clients and have a thorough systematic approach as well as an outgoing, enthusiastic personality. This will stand you in good stead to benefit from this outstanding career opportunity, as well as a generous and competitive benefits package.
Job Offer
Full Study Package
Opportunity to work for a Top 20 practice!!
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text:
Hi everyone, my name is Nikki. I have been lurking on here for quite some time but haven't found the courage to post anything until now. I am a (possible) Pre-Eclampsia and partial HELLP syndrome survivor…if you can call it that. Today would have been my due date - which should have been around the time we were supposed to be able to take our son home from the NICU. Here is our story:
My husband and I decided last summer that we were going to try to start our family. We made a plan for me to stop birth control, give it a couple months to get out of my system, and then start trying in August. I remember having taken several cheap pregnancy tests after the first round of trying and they all came back negative – but still no period. I was convinced that I wasn't pregnant yet but waited another week to test again; I went out early one morning and bought a more expensive, brand-name pregnancy test. I remember sitting in the bathroom watching the positive pregnancy line show up and thinking that I must be seeing things, I yelled for my husband to come look and he confirmed that he saw the line too! We were completely shocked that we got pregnant right away but so excited and already in-love with our baby and our future as parents.
The pregnancy was pretty uneventful for the most part. I was tired a lot during the first trimester and got sick for maybe a month, but other than that things seemed to be going perfectly. We went in for our 18 week appointment on January 4th, they did the anatomy scan and we found out that we were having a BOY…we had already decided that he would be named Aiden!! He was measuring exactly the size he was supposed to and everything looked great. Little did we know how drastically things could change a month later.
A couple days after my birthday on January 25th, I started getting an intense pain in the middle of torso (right below my rib cage and right above my stomach). I brushed this off as pain associated with my hiatal hernia and G.E.R.D. that I was diagnosed with years prior. I hadn't experienced pain that sharp or severe with it before but I assumed that it was just because my organs were being pushed up from my expanding uterus. The pain was so severe that night that I couldn't breathe and I wasn't comfortable unless I was in the shower or on my knees in bed. I was throwing up everything that I tried to keep down including all of the indigestion/acid reducing meds that I tried to take. My husband got so concerned that he ended up taking me to the emergency room at 1am. This was after the nurse practitioner that called me from my OB's emergency line told me that "if I went into the hospital with heartburn I would just be waiting a very long timeâ€. We got to the hospital and I was seen right away. They gave me some pain meds, did lab work and did an ultrasound to check out my little man and if they could see anything going on in there. They noticed that my liver was slightly enlarged and that my liver enzymes were elevated but told me to bring it up to my OB at my follow-up appointment two days later. They released me with a diagnosis of a UTI (which I was given antibiotics for but had no symptoms of whatsoever).
When I went into my OB's office for the follow-up, I mentioned the elevated liver enzymes and he told me that he would look at my records and call me if he thought it was anything to be concerned about; in the meantime he referred me to my gastroenterologist to look into my pain further. I never received a call back from him.
That weekend the pain started up again on Friday night and did not leave until Sunday afternoon. I had made my appointment with the gastroenterologist on the following Tuesday so I decided to wait it out rather than go to the emergency room with no results again.
The following Tuesday I went to my gastroenterologist who said that she did not think the pain was associated with my stomach but more likely with my liver (because the pain was shooting down instead of up). She was the first person to ever mention any pregnancy related liver problems to me. She was also the first person to tell me that my platelet count was low from my hospital records. She asked me to go back to my OB, show them what she told me about and make sure they keep a close eye on me. I never got a chance to follow-up.
That afternoon the pain started again and my concerned parents called my OB's office who told them to immediately bring me to the area's best hospital for pregnancy related issues. I was admitted that night and did not leave for two and a half weeks.
During my time at the hospital I went through so many doctors with different opinions that it makes my head spin just thinking back on it. The doctor that I had when I first got there was leaving a couple days later for a medical conference in San Francisco. The doctor covering for her over the weekend barely looked at my case and was ready to discharge me because "everything was looking good†at the time. Come Monday, the last doctor covering for her came in and said that things were steadily declining and they would need to discuss having to deliver early (I was 23 weeks along at this point). Imagine being told one day that you can go home and the next day that you might have to deliver your baby who "is not considered viable at 23 weeks yetâ€. During this time they did another growth ultrasound on Aiden and discovered that he was now measuring 2 weeks behind in size. They discussed the IUGR issues with me but said that he was not considered at that point yet (but was probably on his way there by the looks of it). They also found that the blood flow in one of my umbilical vessels was lower than the others. During this time they were continually checking my blood pressure and doing urine tests on me (although I did not know the reason for them at the time). My blood pressure was always normal and I was not spilling any protein. My liver enzymes and platelets continued to rollercoaster, one day up…the next day down. There was so much guess work and information being thrown at me and my husband that we didn't know what to make of it. We were told that I had HELLP Syndrome and that the baby was growth restricted and would not grow any more if I stayed pregnant, then other doctors came in and disagreed. There was still the idea floating around that my pain was associated with the hiatal hernia. The doctor whose care I was under the week before I delivered Aiden had me so upset and stressed out that my husband and I referred to her as "Dr. Doomâ€, who made me cry every time I had to talk to her. I made the decision that the 1st doctor (who was in San Francisco at the time) should be in charge of my care from out of town. She seemed like she knew what she was talking about and did not try to scare me into delivering. She disagreed that I had HELLP syndrome because I did not have the hemolysis but did say that if my blood pressure started rising and went over 140/90 twice, they would have to immediately deliver. They gave me the steroid shots right away (which helped my platelets rebound) and kept checking Aiden's heartbeat and my blood pressure. After I was told that my blood pressure couldn't hit 140/90, I was panicked. I had an anxiety attack anytime a blood pressure cuff came anywhere near me. I would lie in bed, hear the blood pressure monitor be rolled down the hallway to me and be screaming inside. The Friday of the 2nd week I was in the hospital, my blood pressure finally hit 140/90 after continually rising the previous days (and by hit it, I mean that it only hit that, never went above the baseline). The 2nd time it hit 140/90, my husband and I immediately started crying. End game. The thing we were fearing and fighting against the most was about to happen and there was no more fight left in us. To this day I still believe that my blood pressure was completely situational and in no way had to do with PE. I never spilled any protein, was never swollen, no weight gain (in fact, at that point I was still down 8 lbs. from my pre-pregnancy weight). They told me that I was severe pre-eclamptic and that they would have to immediately deliver. Aiden was kicking me this whole time, like he was telling me "I'm still here, don't give up yetâ€. I was brought to Labor and Delivery that night and put on the mag-sulfate drip right away.
I delivered Aiden by emergency c-section on February 12th. He was 15 oz. and 10.5 inches long and he came out fighting. I remember being in the operating room with my husband holding my hand and they never even announced that he was out. I was lying there listening to any kind of news because I knew that there was a pretty big chance that he was too small to be successfully intubated. I heard the NICU people in the room say that he pinked up right away and that he was kicking a lot, that's how I learned that he was born. After a few minutes they came over to my husband and asked if he wanted to see him and his response was "he's out already?†(I was focusing so hard on hearing anything being said that I didn't tell him that I knew he was already out). He went over and saw our baby boy for the first time and got to touch him for the last. When he got back over to me he was crying and told me how beautiful he is. Soon after, they wheeled him to me for a minute so that I could see him before they took him to the NICU. He was absolutely the most perfect thing that I had ever laid my eyes on; I could tell right away that he had my hands & feet and my husband's nose and ears.
I was wheeled back to my room in labor & delivery and laid there while family came in little by little to congratulate me. I remember being so happy and peaceful at the time because I felt like if he made it through delivery, he was going to survive anything. The nurses and doctors kept reassuring me that they had never seen a baby that small with that amount of fight in him; he was our miracle baby and we were going to get to keep him. I sent my visitors to see the baby in the NICU with my husband, planning out the long road and months of NICU visits that were going to be ahead of us. I didn't see him again until the following day because of the 24 hour Mag-Sulfate drip. They wheeled me down to the NICU and I got to sit with Aiden and watch him kick and move his arms around in the incubator. I was in complete amazement, I couldn't even speak.
Everything came crashing down on me the Tuesday after I delivered. A resident in the NICU told me that Aiden wasn't doing well and there wasn't anything else that they could do for him beyond what they were already trying. I called my husband to leave work because we were told that it would be a good idea to spend as much time with him as possible that day. I sat in my hospital bed crying and waiting for my husband so that we could go say goodbye to our son together. The attending came in (who was the head of the entire NICU department) and told us that he was doing better and then told us that there were things they could do if things went wrong again (that resident from earlier knew to stay away from me from that point on). I went to see Aiden as much as I could while recovering from the surgery and still being weak myself. A very kind nurse one night asked me if I had been allowed to touch him yet and I responded "noâ€. She shook her head as if to say "that's ridiculous†and opened up his incubator allowing me to touch his hand, his arm and the side of his face. She told me that no matter what the weird circumstances were around our lives in the NICU, I was still his mom and she was his nurse. While she was his nurse I would be able to touch him when he was stable and change his diapers if needed, it was her job to take care of his health and my job to be his mom. For as long as I live; I will never forget those words and being allowed to touch him for the first (and as it turned out, the last) time.
As much as I wanted to stay positive for our little man, I couldn't shake away the constant fear that was now a part of my every thought. The Thursday that I was to be released from the hospital, we were told that Aiden had a brain bleed and that it was a Level 4 (the worst level) on one side and a Level 1 on the other. We were told that we had decisions to make and that this could mean that he would be blind, deaf, or have cerebral palsy. My husband and I decided that there was really no decision to make. He was our son and as long as he was willing to keep fighting, we would keep fighting for him. I would not give up on him because of obstacles that were a possibility, not a definite. He stabilized over the next several days and I was out of the hospital (with a severe chest cold that I picked up in the hospital) and still weak from the surgery. I made every effort to go in to see him as much as possible. I made sure to keep my germs as far away as possible from him and the people that cared for him but I could not go a day without seeing my baby.
The night of Tuesday February 22nd, we got a phone call telling us that Aiden's heart rate had dropped and they were having a hard time trying to bring it back up. They were doing everything they could but felt that we needed to get to the hospital as soon as possible. We dropped everything we were doing (I was pumping at the time) and went to go see our baby boy, the whole time praying that they were able to revive him and everything would be okay by the time we got there. We got to the hospital about 25 minutes later and the doctor was waiting for us in the hallway of the NICU. She told us that they did everything they could do but that he was gone. I collapsed into my husband's arms sobbing while they led me into the room to see my baby boy. My dad had gotten to the hospital before us and was standing at his bedside crying over his grandson. I was sat down in a rocking chair in the NICU room (with 3 other babies in incubators around me) and given my son, swaddled in a blanket and finally at peace. It was the first time I ever got to hold our sweet beautiful boy, and he was gone. I never got to see him open his eyes or kiss his cheeks…and I never got to say goodbye. This experience was the hardest thing that I have ever gone through and I am haunted by it every day. The pain is still there but it changes with time; sometimes it is a dull ache and sometimes it is a piercing constant reminder of what has been taken from us. My husband and I plan on starting counseling soon so that we can try to navigate our way through this time together. In the meantime I spend most of my time being sad and resentful on the inside. I am still learning how to be this person; the childless mother, who has more regrets than she can count. The "what ifs..?†only seem to accumulate and I'm left with no answers and an empty nursery. My brain realizes that it is not my fault and that I did nothing to bring this on myself but I wish my heart would understand that. I feel betrayed by my own body and lost without our son. Sorry for this ending up being so long but thank you so much for listening to our story.
New here - Due date today (very long)
A place for those bereaved to receive and offer support
- Aidensmommy212
- Registered User
- Posts: 14
- Joined: Wed Mar 30, 2011 7:11 pm
New here - Due date today (very long)
Nikki (28) & hubby Blaine (40)
Mommy to Aiden Blaine - 15 oz./10.5 in. w/ IUGR
Born 2/12/11 @ 24+1 weeks due to Severe PE & HELLP
Lived 10 days, loved and missed more than words can say
Mommy to Aiden Blaine - 15 oz./10.5 in. w/ IUGR
Born 2/12/11 @ 24+1 weeks due to Severe PE & HELLP
Lived 10 days, loved and missed more than words can say
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SIMATIC PCS 7 Introduction of APC-Functions (E-PCS7APC)
Dates et inscriptions
Cursus de formation
Advanced process control (APC) is being increasingly offered to users directly within process control systems. As a user of SIMATIC PCS 7, this course will provide you with an overview of the possibilities for improving the performance of your system using appropriate functions from the SIMATIC PCS 7 APC portfolio. Starting with standard PID controllers, further advanced controller blocks and templates from the APC portfolio will be presented. You will not only be provided with an insight of their fundamental functional principle and application, you will also gain practical knowledge of the relevant control parameters. This nevertheless does not require knowledge of theoretical formulas and calculations. Using exercises on training equipment, during which you can practise operations under real-life conditions, you will be able to implement your theoretically gained knowledge, thus consolidating and increasing the success of your training. The basis for the practical exercises in the course is the APL (Advanced Process Library) of SIMATIC PCS 7. However, the knowledge gained with regard to APC functions is independent of the library. Following the course, you will be able to configure control solutions for process automation optimally and efficiently.
Groupes cibles
Project managers, project assistant
Commissioning engineers, planners
Service engineers, maintenance engineers
Programme / Contenu
Overview of APC tools in the SIMATIC PCS 7 libraries and APC examples
Control performance management
Design and principle of operation of the standard PID controller
Monitoring of control loops using ConPerMon
Computer-aided optimization of control loops (PID-Tuning)
Split-range control
Cascade control
Smith predictor control for dead time systems
PID control with parameter control dependent on working point (gain scheduling)
Attendance of ST-PCS7SYS or ST-PCS7APL course is recommended
Basic knowledge of process control engineering
Practical experience in configuration of SIMATIC PCS 7
Course documentation: English
Trainer: English and Dutch/French
Formation en salle
2 Jours
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Informations sur l'entreprise
Protection des données
Condition d'utilisation
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