text:
ICAC Ambassador Programme
Starting from 2013/14, HSUHK partners with the Independent Commission Against Corruption (ICAC) and participates in the ICAC Ambassador Programme (廉政大使計劃) to enhance students' awareness on anti-corruption and maintain high level of personal integrity.
The programme provides students the opportunities to understand the mission of ICAC, explore topics of integrity and commitment, and enhance their capabilities to conduct collaborative promotion activities. By joining the programme, students will be able to demonstrate their creativity in organising campus activities, gain the sense of achievement from teamwork and meet with new friends from other institutions.
- September: Recruitment of ICAC Ambassadors
- October: Selection Interview
- November: Input Session & Training
- January – June: On-campus integrity Promotion Activities
- June: Closing of ICAC Ambassador Programme
Benefits of Joining the Programme
Ambassadors will gain an opportunity to:
- join as ICAC Voluntary Summer Helper
assist/participate in various ICAC activities
- network with former ICAC Ambassadors of other institutions by joining the i-League and make continuous contribution in probity promotion
Application (2019/20)
Interested students please return the completed application form to the Student Affairs Office (M603, 6/F, Block M) on or before 23 September 2019 (Monday).
Shortlisted candidates will be invited to an interview on 11 October 2019 (Friday).
Download: Application Form Programme Leaflet

subset: commoncrawl


text:
Today I had an excellent walk around St-Lazare sand pits with Richard Yank. We started at the west end of the complex and our first net success was a male River Bluet Enallagma anna (l'agrion à longs cerques). Photos were duly taken and the insect released, interestingly it was well away from the initial discovery site of last year – encouraging that they are still present and that we seem to have a viable population, albeit a very small one.
The bluet was the first lifer that Richard was hoping for, next came a couple of Brush-tipped Emeralds Somatochlora walshii (Cordulie de Walsh) that gave us the opportunity to show how athletic an ode-netter we both were. Needless to say they got away with a level of consistency that shows cunning but they did show well in the bins. As the morning warmed up so did the Eastern Red Damsels Amphiagrion saucium (Agrion rougeậtre), lifer #3. A passing Wandering Glider Pantala flavescens (Pantale flavescente) was a first of the year for me with a few more seen later as we went into the pits proper looking for saddlebags.
While scouring the pools we came across an active Black-shouldered Spinyleg Dromogomphus spinosus (Gomphe épineux), a new species for the site (#77). In the same area we had many Eastern Amberwings Perithemis tenera (Périthème délicate) and a few Halloween Pennants Celithemis emponina (Célithème géante), another first of the year for the site and pleasing to see as it confirms colonisation. At one point we did flush a saddlebags, it flew out over the water and away and we didn't get onto it too well and couldn't re-find it. It was interesting enough that I went back later to try again but no luck but there is always tomorrow. On my return I netted a Marsh Bluet Enallagma ebrium (Agrion enivré), new for my personal site list.
Below is the list, those marked * I added when I went back after Richard had departed.
Lyre-tipped Spreadwing Lestes unguiculatus (Leste Onguiculé); Slender Spreadwing Lestes rectangularis (Leste élancé); Northern Spreadwing Lestes disjunctus (Leste disjoint; Emerald Spreadwing Lestes dryas (Lesta dryade); Amber-winged Spreadwing Lestes eurinus (Leste flamboyant); Orange Bluet Enallagma signatum (Agrion orangé); Skimming Bluet Enallagma geminatum (Agrion minuscule); *Marsh Bluet Enallagma ebrium (Agrion enivré); Northern Bluet Enallagma annexum (Agrion porte-coupes); *Stream Bluet Enallagma exsulsans (Agrion exilé); Hagen's Bluet Enallagma hageni (Agrion de Hagen); Azure Bluet Enallagma aspersum (Agrion saupoudré), *Familiar Bluet Enallagma civile (Agrion civil); Tule Bluet Enallagma carunculatum (Agrion des scirpes); River Bluet Enallagma anna (l'agrion à longs cerques); Sedge Sprite Nehalennia irene (Déesse paisible); Eastern Red Damsel Amphiagrion saucium (Agrion rougeậtre) ; Eastern Forktail Ischnura verticalis (Agrion vertical); Green Darner Anax junius (L'anax) ; Lake Darner Aeshna eremita (Aeschne porte-crosses); Black-shouldered Spinyleg Dromogomphus spinosus (Gomphe épineux); Brush-tipped Emerald Somatochlora walshii (Cordulie de Walsh); *Common Baskettail Epitheca cynosura (Épithèque à queue de beagle); Prince Baskettail Epitheca Princeps (Épithèque princière); Twelve-spotted Skimmer Libellula pulchella (La gracieuse); Common Whitetail Plathemis lydia (La lydienne); Widow Skimmer Libellula luctuosa (La mélancolique); Four-spotted Skimmer Libellula quadrimaculata (La Quadrimaculée); Calico Pennant Celithemis elisa (Célithème indienne); Halloween Pennant Celithemis emponina (Célithème géante); Saffron-winged Meadowhawk Sympetrum costiferum Sympérum rubigineux); Band-winged Meadowhawk Sympetrum semicinctum (Sympétrum semi-ambré); Cherry-faced Meadowhawk Sympetrum internum (Sympétrum intime); Dot-tailed Whiteface Leucorrhinia intacta (Leucorrhine mouchetée); White-faced Meadowhawk Sympetrum obtrusum (Sympétrum éclaireur); Eastern Amberwing Perithemis tenera (Périthème délicate), Wandering Glider Pantala flavescens (Pantale flavescente).
A now a few images: Lyre-tipped Spreadwing; Northern Spreadwing (three images); River Bluet; Emerlad Spreadwing; female Lyre-tipped Spreadwing; Halloween Pennant; Eastern Pondhawk; Eastern Amberwing.


text:
Michael Turner, the chairman of brewer Fuller Smith & Turner, has lashed out at "short-term investors" who have been targeting other asset-rich pub groups and pressuring them to sell off or spin out their freehold properties.
In particular, he attacked property investor Robert Tchenguiz, who controls 27% of larger pub group Mitchells & Butlers and, after years of battling, has won two seats in the boardroom. Tchenguiz last month finally persuaded management to draw up plans to separate out the properties in a tax-efficient real estate investment trust (Reit).
"We cannot see how anything that is happening with reits there [at M&B] can be described as 'long-term'. I don't think it will be good for the industry and I don't think it will be good for customers," said Turner.
Several other pub groups are also looking at stripping out their property assets into a reit, with Enterprise Inns having secured technical approval to do so from Revenue & Customs.
Fullers finance director James Douglas said: "We can only watch in bemusement as others explore separation [of their real estate assets]." Turner said: "We have always said it is in the interests of shareholders to own the freeholds wherever possible." Fullers has 363 pubs, two-thirds of them tenanted, with 90% freehold ownership.
The Fullers chairman said M&B, if stripped of its property, would "by definition leave an operating company that will be tied into high street leases and I think everybody is aware of what has happened to that kind of business - the best example is Laurel Pub Company."
Laurel, which includes the Yates and Slug & Lettuce chains also owned by Tchenguiz, collapsed in March after failing to find a buyer for about 90 loss-making bars within the 330-strong group.
Twelve months ago, weeks before the credit crunch spread to the UK, Turner said: "Sadly, we live in a world made up of short-term interests. It is quite easy to rape any business for short-term gain these days." Yesterday he said his comments had been vindicated.
Turner said his company's focus on conservative borrowings and its determination not to sell off freehold pub assets had been vindicated as heavily indebted rivals and competitors labouring under onerous leases struggled amid the toughest trading environment in working memory.
He contrasted the long-term view taken by the three founding families who control the majority of Fullers' A and C shares and the approach taken by Tchenguiz and his supporters at M&B.
Turner also criticised lager price promotions in supermarkets. "To use loss-leading or low-cost alcohol sales as a traffic builder in a store cannot be described as responsible retailing," he said.
He said lager brands, particularly InBev's Stella Artois, faced a "big challenge" to recover their image and pricing. "Those brands that are heavily discounted in supermarkets but then want to be premium in pubs have a serious problem."
Reporting underlying pretax profits up 4% at £23m, Fullers yesterday warned commodity prices were continuing to drive up the cost of food and beer.


text:
Questions? Call 844-735-5386
Email email@example.com
Customizations Total: $0.00
Smart Scales have the capability to be connected to your computers, tablets, and Smartphones via USB, Bluetooth, Wifi and Radio Frequency channels.
carries many different inexpensive software so you can process, save, print and distribute the weighing data on your devices.
Smart scales could easily enhance your productivity and save your labor costs.
Even if you are not ready for the Smart Scales additional options, it is always a good idea to purchase a 'Smart Scale Ready' device so you can upgrade them anytime you think it's time. At, we strive to provide Excellent product & service!
Extra charges do apply for all upgrades mentioned. please contact us
If you are going to use the scale outdoors, you Must have Stainless Steel indicator, Stainless steel Load cells & Stainless steel junction box. This is to reduce / Eliminate chances of rust & Error in readings.
Scales are not waterproof "AS IS" but we could upgrade it, So in case you leave it in the rain or if you are located in regions of the country that is humid, it can still operate.
Total price for upgrade to Stainless Steel Load cells, junction box & Stainless steel indicator is: $399
FREE SHIPPING to a business address in US 48 continental States.
$100 Extra shipping cost to residential.
$50 Extra for lift gate services. So if you don't have a forklift you will need this service.
Hawaii, Puerto Rico & Alaska customers please call for a shipping quote.


text:
MLA Paper
This template is based off the guide lines in Modern Language Association Handbook.
Project Description
This template provides examples of how to setup your MLA paper and how to use the format properly. Simply overwrite the examples with your own work. Ensure you don't leave anything behind. The date will auto set to the current date specified by your computer. If you want a different date just replace the text. For submitting electronically - Keep in mind that LibreOffice uses .odt by default. Because of this and the fact that a lot of instructors use Microsoft Office you might want to save your paper in .docx or .doc format. You can open this document in Microsoft Word 2016 if the application has access to the internet. I would ask your instructor what format he wants. When in doubt use .doc.
- Printing
If your paper looks strange printed, then please read the paragraph below.
Check your printer settings on the physical printer and host machine. These settings are separate to the printing prompt in LibreOffice. Make sure you do not have any setting that will shrink the page to fit borders. If you use a CUPS print server then set the Shrink Border setting to "Crop (preserve Dimensions)" Paper size is US Letter: 8.5x11 inches. To make sure your page is perfect use a imperial ruler and measure the borders. They should be exactly 1 inch from all sides with the exception of the bottom depending how your paragraph structure came out. The Header will be .5 inches for the top and 1 inch from the right side. If the measurement is more than a 16th of an inch off, your printer settings are wrong or your paper tray needs adjustment.
Academia, Education, Writer, Paper,
Current Release
MLA Paper - 2.2
Released Jun 30, 2017 — tested with:
LibreOffice 3.3, LibreOffice 3.4, LibreOffice 3.5, LibreOffice 3.6, LibreOffice 4.0, LibreOffice 4.1, LibreOffice 4.2, LibreOffice 4.3, LibreOffice 4.4, LibreOffice 5.0, LibreOffice 5.1, LibreOffice 5.2, LibreOffice 5.3,
Font Styles updated.
More about this release…
All Releases
Template Version
MLA Paper - 2.2
|Font Styles updated.
Legal Disclaimer and Limitations for Downloads
The Document Foundation has not reviewed, and cannot review, all of the material, including computer software, available on or by means of The Document Foundation's
websites, and cannot therefore be responsible for that material's content, use or effects. By operating its websites, The Document Foundation does not represent or imply that it endorses the material there available, or that it believes such material to be accurate, useful or nonharmful. You are responsible for taking precautions as necessary to protect yourself and your computer systems from viruses, worms, Trojan horses and other harmful or destructive content. The Document Foundation's websites may contain content that is offensive, indecent or otherwise objectionable, as well as content containing technical inaccuracies, typographical mistakes and other errors. The Document Foundation's websites may also contain material that violates the privacy or publicity rights, or infringes the proprietary rights, of third parties, or the downloading, copying or use of which is subject to additional terms and conditions, stated or unstated. The Document Foundation disclaims any responsibility for any harm resulting from the use by The Document Foundation's visitors of The Document Foundation's websites, or from any downloading by those visitors of content available on or by means of The Document Foundation's websites.
Content contained on The Document Foundation's websites, including these Legal Disclaimers and Limitations, may be changed at the sole discretion of The Document Foundation and without notice. You are bound by any such updates or changes, and so should periodically review these Legal Disclaimers and Limitations.
If you believe any file is present on the site contrary to any TDF rule or applicable law, please supply full details to firstname.lastname@example.com for impartial consideration.


text:
I know that I've talked about it here a million times and I'm sure that people in my life are sick of hearing it, but yoga has changed my life in so many ways that it's hard not to talk about it. Where once anxiety waited around every turn, preying on my weaknesses, telling me that I would never amount to anything and that each little task was a mountain to climb, I now have tools to keep it away and keep myself strong. Where I once saw the words "no," "I can't," "never," I now start to see "I can" and "I will." Anxiety still lives down inside of me, sometimes bubbling up to take over, but now it is easier to push it back down and make it behave. Anxiety now lives largely in the background, leaving the rest to be filled with living life. Some of this is because I found a great psychiatrist. Some of it is because I've gotten older and more comfortable with myself. But a large part of the credit goes to yoga.
Because so much of my anxiety is centered around my body and health, yoga is an excellent counter to it. If I can control what my body does in so many ways, there is less room to find fault with it. Add a little meditation and breathing to interrupt those ruminations and yoga is the perfect recipe for my particular brand of anxiety.
I still find myself daunted by certain tasks, especially those that might interrupt the calm(ish) little life I've got going here. But it has come to a point where my life needs a shake-up. I need to push past the "I can't" and into the "I will." So again, I'm turning to yoga
7 years ago I couldn't do this.
5 years ago I couldn't do this.
1 year ago I couldn't do this.
If I can hold warrior II, balance on my arms, and freakin STAND on my HEAD, I can do anything right? At least, that's what I tell myself when my mind is full of doubts. Yoga reminds me that I am strong, that I can overcome fear, and that I have control. With that on my side, the only thing left to do is to move forward.


text:
A Post By: Craig Sean Right now I'm high, flying at 34,000 ft at 582 miles mph.... High as a kite. Spent some time in the city yesterday getting the necessary last minute supplies. Got some snacks for the plane, some spending cash, and other random things. (Just spent a few minutes reading over the … Continue reading Craig Sean Around The World: Heading to Bangkok
Month: January 2014
Cody: Things That Would be a Pleasant Surprise
A Post By: Cody DiCavalcante Toilets that ejected a life size Gary Coleman when you flushed them General Robert E. Lee giving Johnny Carson a lifetime acceptance speech A sewer full of guilty men that you prosecuted Tap dancing cell membranes under a microscope L.A. shaking hands with New York Kids trick or treating in … Continue reading Cody: Things That Would be a Pleasant Surprise
Tales From America: Rat Wrestling in Iowa
A Post By: Big Jim Ryder There are two things I care about in life: 1) My momma 2) Rat wrestlin' I've been rat wrestlin' on the amateur circuit for 5 years now. It all started like a dream. With Rat Wrestling Thursdays at Fat Al's Bar. I was the best around. Fat Al was … Continue reading Tales From America: Rat Wrestling in Iowa
Using the Term "Rape" to Describe a Sporting Event
A Post By: Michael Gallo You might not believe this, but a "comedy" website is about to drop some truth (the word comedy is in quotes, because I know A LOT of people who would disagree with the use of that terminology in regards to this website). People are getting a little too liberal with … Continue reading Using the Term "Rape" to Describe a Sporting Event
Cody: Things I Want to Accomplish in 2014
A Post By: Cody DiCavalcante Introduce myself to sports talk Buy a cat and sharpen my sarcasm skills Gladly accept those pamphlets from the people outside the library Stand in front of a vacant building and envision a glorious adoption clinic with rainbows and smiling donuts and then shoo the idea and move to Anaheim … Continue reading Cody: Things I Want to Accomplish in 2014
NFL Predictions and Gambling
A Post By: Michael Gallo Congratulations on making it this far into the NFL season without losing all of your life savings and having to move to Thailand where you open up a small noodle shop and refer to yourself as the Great White Ghost. I've seen too many people hit rock bottom from sports … Continue reading NFL Predictions and Gambling
BL Sports: The New York Yankees Sign a Grandpa
A Post By: Michael Gallo It would seem that the New York Yankees are in constant pursuit of one day having a player actually die on the field. However, unlike the barbaric NFL where the first on-field fatality will come from a head-to-head collision at 89 mph, this on-field fatality will be from old age. … Continue reading BL Sports: The New York Yankees Sign a Grandpa


text:
Inquest: The Malware Magnifying Glass
OPSWAT and InQuest partnered to provide a joint solution that identifies malware using multiscanning technology and sanitizes the infected files. The combination of OPSWAT's advanced threat prevention and InQuest's high-speed network monitoring platforms is powerful, effective and unique in the security industry. OPSWAT's MetaDefender platform provides a host of critical services such as multiscanning, Data Loss Prevention and data sanitization (CDR).
InQuest specializes in collecting raw session data from your network streams and is capable of handling even the heaviest of workloads. Once we have that data, we put each component (IP, headers, files, certificates) through everything and the kitchen sink. InQuest's deep file inspection ensures every piece of content gets extracted and put through the gauntlet. InQuest solutions come packed with several tools designed to identify and correlate threats in your environment; these are our internal integrations. These services leverage the knowledge base collected and maintained by researchers in our InQuest Labs. But our knowledge base only scratches the surface and the philosophy once again is to cast the net deeper and wider, thus we put a priority on external integrations as well. These include a handful of sandboxes, antiviruses, and exchanges all of which automatically receive work from InQuest and whose findings are packaged back into a consolidated view and a calculated "Threat Score."
Getting the Most Out of Your MetaDefender
Let's look at how the combined OPSWAT & InQuest solution maximizes the strengths of both offerings. When this integration is enabled, all valid files entering your network will automatically be submitted to OPSWAT for analysis. Results from the antivirus engines will be retrieved and evaluated. If these results indicate a file might be infected, we will factor this into our Threat Score for this file. The InQuest 10,000 ft session view (see above figure) will give the indication that OPSWAT detected a threat and you'll be able to dig into the Scan Results page (see below) to see which antivirus engines fired and what they had to say.
OPSWAT MetaDefender Core Hosting
Get started by targeting your OPSWAT deployment. Hosting parameters is the familiar getting started configuration of any external integration. Tell us where to look and we will start sending your files to OPSWAT, no matter where or how you've deployed it.
Target your OPSWAT deployment, no matter where or how it's hosted
Making Malware Magic
InQuest's partnership with OPSWAT is founded upon the desire to provide customers with InQuest's cutting-edge network monitoring and robust automation techniques combined with OPSWAT's Advanced Threat Prevention using multiscanning services. The integration of these two forces provides a powerful and robust pipeline for evaluating the files coming into your environment.
The InQuest-MetaDefender joint solution provides customers with an advanced malware detection and analysis platform capable of detecting malicious content that bypasses other perimeter defenses.
Learn more about the MetaDefender Advanced Threat Prevention Platform. Evaluating the efficacy of MetaDefender engine is straightforward; simply upload your file to the MetaDefender Cloud and check the multiscanning results in seconds.
For a deeper understanding of InQuest's all-encompassing network threat eradication platform, go to https://inquest.net/.
- File Upload Protection – 10 Best Practices for Preventing Threats
- Infographic: File Upload Security – A Mission Against Malware
- Can You Spot the Social Engineering Techniques in a Phishing Email?
- We Released an Advanced Email Security Comparison Guide
- Vulnerabilities: CVEs, Hashes, Application Installers Report January 22-29, 2018
- 6 Potential Security Gaps in File Transfer Process for Critical Infrastructure
- Police Handing Out Malware-Infected USBs Is Not an Isolated Incident
- 10 Things to Include in Your Employee Cyber Security Policy
- 11 of the Largest Data Breaches of All Time (Updated)


text:
WELCOME to the online art gallery of Singer/Songwriter, Lisa McClowry. Here you will find Lisa's original Abstract Fine Art paintings and prints. New prints are added every week. Please visit often.
FREE SHIPPING on orders $50 or more! In the USA only.
Copyright © 2020 Lisa McClowry Works of ART. All Rights Reserved.
Website by CGA Media


text:
Pistol Classes
Personal Safety Classes
Valuable TIPS & Event Pictures
October 29, 2018
Happy Bday
Youth Steel Challenge Practice
March 18, 2017
Best co-instructors ever!
September 23, 2019
Event Pictures Womens Intro to Pistol 9/22/19
Women's Intro to Pistol Event
Colorado Realtor attacked during open house
August 7, 2019
South Dakota Ladies love revolvers
June 29, 2019
Saturday morning Women's Intro to Pistol
Friday Evening Women's Intro to Pistol
Dam skunks. Yep Jessie got it.
"Next Steps" how to clear malfunctions, table pickup, emergency reloads & strong hand only lessons.
SD Classes have been amazing!


text:
Turkey: Investors eye real estate potential
Reforms to property laws, years of solid economic growth and political stability have combined to produce a real estate boom in Turkey. Buoyed by growing investor interest, which is particularly high in top-end developments, property prices in Turkey are rising rapidly, with luxury flats in Istanbul estimated to have more than doubled in value during the past eight years, surpassing $4500 per sq metre.
According to British real estate firm Knight Frank, Turkey recorded the third-highest property price growth rate in the world in the first six months of 2012, outpacing well-established hotspots such as Russia, which is a rising investment market, and Hong Kong, where supply is constrained by space.
International press reports suggest that the current influx of foreign investment could sustain the market in the long term, despite risk factors that include slowing economic growth and inflation concerns. Turkey's Association of Real Estate Investment Companies (GYODER) estimates that the value of property purchased by foreigners could increase from $2.5bn in 2011 to $4bn next year, even reaching $10bn in the medium term.
While other forecasts are more modest, the real estate market is generating a new wave of interest, particularly among cash-rich investors from the Gulf, Russia and Central Asia.
Erdinç Varlıbaş, the chief executive of local developer Varyap, said Istanbul is becoming "a second London for the Arab world", following in the footsteps of the UK's capital city, which has attracted high volumes of investments from the Arab region in recent years.
Turkey's property boom has been fuelled by the government's decision to change key real estate laws, and to scrap the 'reciprocity law' in particular. The reciprocity law had restricted foreign ownership of local real estate to citizens of countries that allowed Turkish nationals to buy property in their countries, such as the UK and Germany. The government also plans to increase the area of land foreigners are allowed to purchase from 30 ha to 60 ha.
Turkey's growth story, macroeconomic stability and sound monetary policy have helped attract international property investors to the country. GDP growth topped 5% for much of the previous decade, despite a brief but sharp recession in 2009. Last year, growth reached an impressive 8.5%, although inflation, which currently stands at 9%, is giving cause for concern.
Turkey has also gained greater political stability since its single-party government came to power and replaced a series of fragile coalitions. Additionally, it benefits from its broad appeal to a diverse range of visitors and well-priced real estate.
"Property prices in Turkey are quite low, thus making it attractive for investment," Alasdair Macdonald, the senior director of Knight Knox International, a property brokerage, told the international press. "Investors could easily get just under 10% capital growth and rental yield of 8% per annum."


text:
Acer Predator Z35 Monitor
Computer Monitor Rental
Get the adrenaline-fueled joyride you've always wanted. Slam the thrusters and boost up to top speed.
Wraparound Gaming
Get a panoramic view of galactic domination with a wraparound game space that pulls you deeper into new worlds.
New Smooth
Experience a whole new smooth. NVIDIA® G-SYNCTM eliminates screen tearing and minimizes stuttering for legendary PC gaming.
Seize Control
Conquer your enemies with Predator GameView. Shooting aim-points and customizable gaming profiles give you the upper hand.
Predator Z35
- Panoramic Wrap Around Monitor
- Underglow Lighting wih Matte Futuristic Finish
- DTS Sound - 2 x 9 Watt Speakers
- Cinematic 21:9 Aspect Ratio on a Curved 35" Screen
- Fast 200Hz Refresh Rate
- Precise Colour Adjustments
- NVIDIA® G-SYNC Creates a Smooth Gaming Experience
Write Your Own Review


text:
This is a story about magicians and the powers that threaten it, or so I think from the first chapter. It begins with a back and forth conversation between father and son, and the son wins in order to see some World Cup action. There is some mystical threat, the Maelstrom, that is threatening Italy. The father is some mage of some kind. Disaster strikes and the leader if left wanting to turn the page to see what happens. (I do)
Does the first 1000 words show it as edited?
Yes, it appears edited. The only thing I saw that might stand out is the story is written in present tense, but at times the story does switch to past tense sometimes.
Ex: "My dad, one of the world's fastest casters, dismissed his ball of lightning and sealed the car door shut with Storm wind. He also charged the handle with a little bit of Storm lightning, it seems, because I get zapped as I grab it."
As far as regular grammar, it reads well.
Do I care about the characters after the first 1000 words?
I did. He kept it simple and started his story about a father and son relationship as told by a POV of a 10 year old. The kid wants to see some World Cup action and the father placates him. I think every man remembers how it is at this age. The father doesn't have to say he loves his son, but this is enough to imply to the reader the unsaid. This is good writing, like in a movie. Show and don't tell.
Do I like the world building?
I do. I like foreign and interesting environments. It was a nice touch adding Italian to the prose. He also sprinkled in some magic and world building the system. I assume the father is a mage or wizard of some sort. There is a Maelstrom threat to everything.
Overall Assessment: Would I continue reading past the 1000 words?
Yes. I want to see what happens after the blackout. Good on the author for wrapping me in so quick.
Overall Story Opening Rating: 4/5 Happy Go-Lucky Red Pandas.
One thing I would have liked seeing:
I prefer past tense with the story, especially since I am assuming 1990 AD (nice touch adding the AD) is in the past and the story is being told today due to the vocabulary the kid is using. Would have liked to know where the mother is. Maybe describe what the heck the Maelstrom is and the total deaths caused and who the father is in the scale of mage types. Would have liked to know why the father's dream is to visit the place, but why he couldn't have bought a plane ticket for this long? Magic spell bubble or something? Is the Maelstrom threatening other countries? How long has this been going on?
The First Chapter can be reviewed here:
Q&A with J.M. Bush
How long did the first draft take to write? The first draft took me three months to write and was at about 73k words.
Did you change the ending in the middle of writing? The ending changed slightly because, during the many rewrites over the course of a year, I added many new chapters from different POVs to show some backstory. This influenced the course of the story in many ways and as a result, the ending was affected.


text:
Vera Inclusion Not Working
Newbie. Please be gentle.
First off a BIG thank you to hek and all of those involved with this. I wrote my own JSON webservice interface to my Arduino sensors and relays. I recently bought a Vera Lite and decided to incorporate my Arduino JSON webservice...and then I came across this. You've saved me countless hours and perhaps even saved my marriage.
I've added the MySensors USB gateway to my Vera Lite. In Devices I see the MySensors plugin along with the Start and Stop inclusion buttons. When I press on the Start button, nothing seems to happen. The button does not stay highlighted, nor does my sensor (motion) appear after restarting it within the 60 second default time frame. I tried adding a momentary button and still nothing seems to happen when I attempt to include the sensor. Should I expect the Start button to be highlighted and/or a message to appear in the message window at the top of the Vera interface page?
I have the latest release of the Vera firmware (1.6.641). The MySensors plug in version is 1.3.
"MySensors - The Marriage Saver" - our new slogan.
I wonder if your Vera really has contact with the Arduino?
You're really using an Arduino Nano? What does the debug prints say when you have the gateway attached to your PC? Do you know how to look in the Vera logs?
When I first started I already had my device powered up then tried to include it. Make sure it is not powered before you press the inclusion button in Vera
@hek Love the new slogan, although I'm sure some of our spouses may disagree. I am using a Nano for the gateway. I wasn't even aware that there were logs (thanks!), but based upon your questions, I suspect the problem may be that I had an Insteon gateway connected to the Vera's USB port and simply swapped it out for the Arduino gateway. Perhaps leaving the Insteon gateway configured in Vera is the cause of my problem. I'll still need the Insteon gateway...because, after all, a man can't have too many gateways. A powered USB hub should arrive tomorrow which will allow me to use both simultaneously. An unpowered USB hub didn't solve my issue (no surprise). I'll test again once the new powered hub arrives. I'll dive into the logs if the new hub doesn't do the trick.
@petewill - I did have the sensor powered up when I clicked the Start button but recycled power within the default inclusion time of 60 seconds. Could there be an issue with having it powered up at the time the Start button was pressed even though it was powered down and up shortly afterwards, or was your issue related to not recycling the power within the inclusion time frame?
Can anyone confirm whether there is a visual indicator within the Vera UI during the inclusion period (i.e. Highlighted Start button, message at the top of the screen, etc.)?
You should see that inclusion mode has started on the vera buttons.
I don't think there would be an issue cycling the power but I'm no expert. It has taken up to 30 seconds to pick up the sensors on occasion. I usually press start in Vera then power up the sensor. You should see that sensors are being found in the gateway.
I tried the powered USB hub and still no luck.
The Vera logs shows the following. The last two lines are in red. Does this mean they are failing?
50 04/05/14 12:13:04.195 luup_log:49: Arduino: Trying for a serial connection <0x2bf61680>
50 04/05/14 12:13:04.196 luup_log:49: Arduino: Serial port is connected <0x2bf61680>
50 04/05/14 12:13:04.196 luup_log:49: Arduino: Baud is 115200 <0x2bf61680>
50 04/05/14 12:13:04.198 luup_log:49: Arduino: Sending: 0;0;4;4;Get Version <0x2bf61680>
01 04/05/14 12:13:31.119 FileUtils::ReadURL 28/resp:0 size 1 http://192.168.1.7/get_status.cgi LEAK this:81920 start:278528 to 0xdc6000 <0x2bf61680>
01 04/05/14 12:13:46.136 FileUtils::ReadURL 28/resp:0 size 1 http://192.168.1.7/cgi-bin/get_status.cgi <0x2bf61680>
I'm using UI6. Could that be the problem?
The plugin has not yet been verified on UI6.
What does your Arduino Nano (<- important) Gateway say when you plug it into your computer and look at the serial output? Did you turn on debug prints when uploading SerialGateway sketch?
In the serial window I'm getting "0;0;ô" followed by several "à" characters.
In the Arduino IDE, I'm seeing this in the bottom window:
Error inside Serial.serialEvent()
java.io.IOException: Bad file descriptor in nativeavailable
at gnu.io.RXTXPort.nativeavailable(Native Method)
at gnu.io.RXTXPort$SerialInputStream.available(RXTXPort.java:1532)
at processing.app.Serial.serialEvent(Serial.java:258)
at gnu.io.RXTXPort.sendEvent(RXTXPort.java:732)
at gnu.io.RXTXPort.eventLoop(Native Method)
at gnu.io.RXTXPort$MonitorThread.run(RXTXPort.java:1575)
I am using an Arduino Nano v3.0.
Malx last edited by
You must set the right baudrate in serial window, otherwise you will only get garbage.
(default 115200)
@Malx Thanks. I checked the baud rate in the Serial Window. It is set to 115200.
I've checked it on a fresh Arduino IDE install and I'm not seeing anything in the Serial Window. I've uncommented the debug line in config.h. If the Serial Gateway is working properly, should I see messages in the Serial Window?
Is anyone using MySensors with UI6?
I switched to the Ethernet Gateway and I'm now able to see that the Inclusion mode is starting. The start button is highlighted and stays in Inclusion mode for 60 seconds. I haven't yet been able to get it to include a sensor and I'm seeing the following in the Vera log files:
0 04/15/14 9:09:04.140 luup_log:55: Arduino plugin: library L_Arduino loaded LEAK this:57344 start:57344 to 0x928000 <0x2c001680>
50 04/15/14 9:09:04.140 luup_log:55: Arduino: urn:upnp-arduino-cc:serviceId:arduino1,PluginVersion, 1.3, 55 <0x2c001680>
50 04/15/14 9:09:04.141 luup_log:55: Arduino: Using network connection: IP address is 192.168.1.77:5003 <0x2c001680>
50 04/15/14 9:09:04.243 luup_log:55: Arduino: Sending: 0;0;4;4;Get Version <0x2c001680>
50 04/15/14 9:09:04.256 luup_log:55: Arduino: urn:upnp-arduino-cc:serviceId:arduino1,ArduinoLibVersion, 1.2+, 55 LEAK this:24576 start:81920 to 0x92e000 <0x2e801680>
01 04/15/14 9:09:04.647 FileUtils::ReadURL 0/resp:404 ERROR:Resource doesn't exist size 29 https://us-device12.mios.com/device/device/device/35021529/kit LEAK this:73728 start:155648 to 0x940000 <0x2c001680>
01 04/15/14 9:09:04.650 JobHandler_LuaUPnP::DoFetchKits server: us-device12.mios.com error:404 unable to parse: (null) <0x2c001680>
01 04/15/14 9:09:05.027 FileUtils::ReadURL 0/resp:404 ERROR:Resource doesn't exist size 29 https://us-device11.mios.com/device/device/device/35021529/kit LEAK this:135168 start:290816 to 0x961000 <0x2c001680>
01 04/15/14 9:09:05.029 JobHandler_LuaUPnP::DoFetchKits server: us-device11.mios.com error:404 unable to parse: (null) <0x2c001680>
08 04/15/14 9:10:29.251 JobHandler_LuaUPnP::HandleActionRequest device: 55 service: urn:upnp-arduino-cc:serviceId:arduino1 action: StartInclusion LEAK this:69632 start:360448 to 0x972000 <0x2ec01680>
The 6th through 9th line are showing errors. Can anyone point me in the right direction?
The errors is not related to Arduino plugin.
You seem to receive the version from your arduino (which means that communication between vera<->gw is working).
Please check the troubleshoot guide and post sensor debug logs for further assistance.
BulldogLowell Contest Winner last edited by
Are you using the capacitors on the radios?
@HEK I went through the troubleshoot guide.
I am using the latest version of the MySensors library. The plugin version does not match the library version (Plugin Version 1.3 vs. Lib Version 1.2+). My understanding based upon another post, is that this discrepancy should be fine.
I've triple-checked the radio wiring.
I have not tried adding a decoupling capacitor.
I am not using an amplified version of the NRF24L01+ chip.
Below is a copy of the sensor debug logs:
These three lines appear about every second:
Relaying message back to gateway.
Tx: fr=255,to=0,la=255,ne=0,ci=255,mt=4,ty=5,cr=136:
Ack: receive timeout
These two lines appear every 10 seconds:
No relay nodes was found. Trying again in 10 seconds.
Tx: fr=255,to=255,la=255,ne=255,ci=255,mt=4,ty=9,cr=184:
@BULLDOGLOWELL I haven't tried the capacitors yet. I'll order some and give it a try. FWIW, I have the radios within a few feet of each other.
If there's anything else you can suggest, I'd greatly appreciate it.
While waiting for the capacitors you can always try to switch radio (if you got the 10-pack) to rule out HW failure.
Which type of Arduino are you using for the sensor side? And what type of regulator (if any)?
@hek That was it. I swapped the radio and all is well. Thank you for your patience HEK!
If you try the "broken" radio with a capacitor it will probably work fine.


text:
There's a dark side to every city. Especially one like LA.
Veda Jayne suede moto jacket, Blazer dress c/o Minkpink, Sunday Somewhere Valentine sunglasses, Chinese Laundry Nikki mules. Shot by Andrew Arboleda in Los Angeles, CA.
Ah, sunny Los Angeles. The city of angels... the place dreams supposedly come true. There's something so iconic about its tree-lined streets, sprawling boulevards, sandy beaches & always blue skies. But underneath its gleaming exterior is just another grimy, big city with a dark history. Maybe darker than most because of the illusory cloud of perfection that hangs over Hollywood.
Perhaps that's why I love the moodiness of the images above, which were actually shot on a sunny, picturesque day with my friend Andrew who recently just relocated back to LA from NYC. They're cinematic in a way, but also somehow reveal the underbelly of a city that's both expanding and decaying at a rapid pace. For me, they seem to capture a mix of melancholy and restlessness. And that's just how my hometown makes me feel at times.
Needless to say, I'm happy to be back in NYC! For the moment at least... let's check in again when it starts to snow.


text:
It goes without saying that nothing is more exciting than the release of new information about the FMLA! Hmmm…well, OK, maybe not for everybody, but certainly for all of us FMLA/ADA Absence Administration geeks hanging out here at the DMEC Compliance Conference. The new guide was designed to provide direction when weaving your way through some of the complicated and difficult to interpret sections of the FMLA process. Also included are scenarios that are known to have caused confusion or gray areas in the past. It is a wealth of knowledge right from the source…..you know, the source you want to be fully compliant with, so they don't come knocking on your door.
Along with the new guide, there is also a fancy new poster for Employer Requirements. No worries though, the one you have is still valid as there are no substantive changes or additions.. The new one is more user friendly, easier to follow, and brighter. For those who always want to be cutting edge, stay tuned. The moment the DOL releases it, we will post it for you.
Because it's just the kind of friends we are, I've included a link to the new guide above. Go make a cup of tea and curl up in your favorite chair. Oh, don't act all too cool for school….you know you can't wait to read it! Enjoy!


text:
Encrypt & Obfuscate Flash
DoSWF has been designed specifically for Adobe Flash SWF Files to keep your Actionscript shielded from would-be hackers! DoSWF guards your important Actionscript code from decompilers and reverse engineering techniques!
Protect SWF Resources
DoSWF has advanced encryption options including the ability to encrypt SWF resources such as images, symbols, graphics and audio files! DoSWF also do protect the SWF file from momery searching!


text:
Your Boutique Hotel in the Heart of Spring Lake Beach Awaits
The Chateau Inn & Suites, situated on the Jersey Shore in the seaside village of Spring Lake, welcomes you to a truly unique hotel experience.
As a resort destination for leisure guests, families and business travelers, you can choose from an array of accommodations and packages to fit your personal style. Midweek getaways, weekend escapes, bed and breakfast plans, wedding and spa specials, and romantic rendezvous are available year round.
The Most Beautiful Guest Rooms and Suites in Spring Lake Beach, New Jersey
Our 36 guestrooms and one-bedroom suites at our Historic Inn have been newly appointed to please the most sophisticated taste. Special room amenities include: high-speed Internet access, bathrooms with imported marble, HD-LCD televisions, JACUZZI®, refrigerated wet bars, wood burning fireplaces, patios, sundecks or balconies.
Our antique filled Brighton Room provides a perfect setting for our Signature Continental Breakfast Buffet, complimentary afternoon refreshments, gourmet coffees and selected teas.
Local Activities and Attractions You'll Love
Known as the seaside jewel of the Jersey Shore, Spring Lake Beach has become a favorite vacation destination for beach goers nationwide. This small waterside town transports visitors back in time to an age of simple pleasures, elegance, and sophistication.
During the mid-1800s, Spring Lake Beach was the getaway for wealthy New Yorkers and Philadelphians. Today, it still retains its Victorian aura with a perfect blend of modern-day activities.
As you begin to explore, you'll find a wide variety of things to do in Spring Lake, NJ. A vast 2-mile boardwalk, a plethora of outdoor activities, delectable restaurants, and year-round events all make for a perfect vacation destination!
You may also simply choose to relax at the Chateau Inn and Suites. Our convenient location places you within walking distance of the pristine beaches, historic downtown shopping district, lake and parks, and other local attractions.
Experience the Best of Spring Lake Beach With Us
The Chateau is nestled between Devine, Potter Park and "The Lake". Just a short stroll away on tree-lined streets flanked by ancient sycamores, you can explore Spring Lake's pristine beaches, ocean pavilions, and two-mile boardwalk. Specialty shops, boutiques, antique stores, art galleries and award-winning restaurants are moments away.
Our goal is to make your vacation experience as memorable as it can be. That's why we offer hot deals, seasonal specials, and room enhancements to take your stay to the next level. Whether you want to treat your sweetheart to a lovely surprise or experience more for less on your next getaway, you're sure to find your perfect vacation package.
We look forward to welcoming you to the Chateau soon!
Ready for your dream getaway? Book your stay with us today or learn more about us and what we have to offer you!


text:
Welcome to The Blending Room webshop!
A little about us. The Blending Room is a small, Hull, East Yorkshire coffee roaster comprising of two people, James and Katie, who have 19 years' experience within the coffee industry. Our coffee life begun as baristas in East Yorkshire coffee bars, James within independent stores and Katie having worked within some of the large chains.
From our humble beginnings on Beverley market, we now source and roast our coffee in small batches for various outlets in the Hull, the Humber region, Yorkshire and North Lincolnshire along with continuing to provide customers across the UK with coffee though our webshop.
Being an independent East Yorkshire coffee roaster, means that we can show our customers the differences in flavour produced by coffee varieties, processing methods, countries of origin and seasonality of coffee. We use our Probat P12 II to roast all the speciality grade coffee we source to their preferred, individual roast profiles. Using 9 years roasting experience and modern software packages such as Cropster, coupled with a strict quality control programme, we craft single origin, espresso and bespoke roast profiles. Above all we aim to treat your roasted coffee with the respect it deserves.
Please do let us know what you think of our coffee and if you have questions, pose them to us here or come and visit us at our market stall in Beverley, Hull Trinity Farmers' market, Humber Bridge Market or at our roastery.
James & Katie


text:
The Welcomed Consensus
Since 1992, our instructors have been dedicated researchers in the field of female orgasm. They teach techniques in communication and sensuality to access and develop a person's sensual potential. They cultivate winning viewpoints on pleasurable living so fun and gratification can become a way of life.
What do you want more of?
Upcoming & Ongoing
Whether a course, video, article or event, we have something for everyone.
April 7-23, 2020 : Tues & Thurs
Online: Essentials of DOing
A home-study personal sensuality class you can take from anywhere.
San Francisco
Course: Common Sensuality
Learn the nuts and bolts of sensuality and how to have a gratifying life.
Northern California
Retreat: 5-Day Foundation
Be immersed in pleasurable living while learning in a relaxed class setting.
Ongoing : Members Area
Guided Research: Online
Current Topic: Sensuality for Innovators for Members in April
Weekly : San Francisco
Event: BenchMark
A social evening of community, connection and fun. All are welcomed to attend.
Listen to our podcast or watch our instructional videos


text:
Research & Development at CoreValue
СoreSearch is a research and development initiative by CoreValue that brings innovation to our Clients while enhancing our internal processes.
Data science research and innovation technologies are powerful instruments to drive value creation in technology-based enterprises.
In order to help you make use of cost effective innovation time, CoreSearch is open to commercial cooperation. Our R&D experts will cut your risk by examining technical feasibility, market exposure and scalability of your new product.
Ready to move forward?
How You can benefit from CoreSearch R&D services
Translating concept into a mature solution, it is critical to verify business and technical feasibility of the idea and investigate risks. Our R&D expertise helps our clients move rising ambitious ideas forward. Our research capabilities, cross-domain proficiency, and advanced innovative thinking allows for deep understanding of the client's needs and provide expedited development and improvement of their solution. We can engineer your success.
Time-and budget-efficient POCs that help with executive decisions
Innovating and satisfying production needs simultaneously
Accelerated development process, ramp-up with reusable components
Hi-Tech, testing, scalability and stability
Wide-ranging technical and non-technical expert pool
Proven and tested methodologies, tools, and techniques
Deep commitment to results focused on increasing client's' ROI
R&D as a Service. Focus areas
We solve real-world problems that impact millions of people in areas such as:
Data Science and BI
We are actively developing data science competence since it is utilized not only in our data-driven solutions, but within a variety of projects, starting from mobile Machine Learning abilities to using Einstein in Salesforce platform, warehousing and data visualization.
- Machine Learning, Deep Learning on big data
- Image, voice, patterns recognition
- Industry available Machine Learning services
- Embedded reporting
- Big data reporting stack
UX Extenders
User-Systems interaction with rapidly evolving technologies like Artificial Intelligence, Internet of Things, blockchain, etc is moving from computing revolution to social evolution. New UI/UX potential brought to the market by Mobile devices, digital assistants, fog computing, is a driving force behind digital transformation resulting in superior user experience.
- AR/VR direction
- Verbal, gesture communication, mimics and other interface extenders
- Mobile Machine Learning capabilities
- Wearable devices, IoT: business domain focused
- Usability: design, analytics and QA
Software architecture and development optimization
This area covers new tendencies in software development and the smooth implementation of the industry standards.
- Serverless and backendless
- Cross-platform solutions
- Business domain trainings
- DevOps
- Applications benchmarking and monitoring
And many more
- Salesforce modules and reusable components
- Distributed ledger applications
- Proprietary products
- Standards & Regulations
Get in touch for more.
Concept and process
We apply our proven technology research and development methods and processes to transform the initial vision and concept into a viable real-world solution, ensuring the product is tailored to your business type:
We conduct a feasibility study of the idea through elaboration, visualization and risk assessment.
We provide a flexible, well-motivated implementation process performed by mature engineers who evaluate the business problem, define business goals and opportunities, and enhance product ideation.
We create a Proof of Concept or MVP, prototypes, mockups, click-through models or any other methodology that will stimulate a future solution or product that is viable, reusable and legally protected as an outcome of the research and development project.
Our goals and objectives
CoreSearch ensures comprehensive R&D efficiency of utmost quality. All of our delivered solutions from concept through established procedures are led by best-in-class information technology stack architects and engineers. Our research and development expertise can help connect diversified parts of a company's strategy and business plan, such as marketing and cost management for better performance and overall efficiency. Here's how we do it.
- Extend and increase the quality of our services by tracking the global information technology landscape and tendencies, and apply them to targeted business domains to bring more value to our Clients, e.g., virtual reality, machine learning, robotics, etc.
- Forestall market demand by tracking local business domain technology, legacy and compliance changes, e.g., new standards, approaches, security regulations, etc.
- Improve software development processes to increase cost effectiveness, e.g., new frameworks, new testing/development approaches, new tools and libraries, current research trends, reuse of our own components, etc.
- Improve media presence through high quality technology research, publications and conference presentations to increase our brand awareness.
- Develop legal instruments to protect methodologies, scientific and technology research, home-grown technology and tools.
- Systemize and organize technology expertise.
Get the most of your technology investment!
Who is this for
- Businesses that want to increase market participation or penetrate new product areas to get measurable results.
- Enterprises that seek knowledge to develop, design and enhance their products, services, information technologies or processes.
- Research and development market leaders seeking resources with the right level of expertise.
- Businesses with the need for scientific and engineering resources to turn their innovative concept into a real business solution.
Our Domain Expertise
For more than a decade within the area of innovative research and development, CoreValue has been and continues to be a one-stop shop for R&D services for enterprises, mid-size clients, startups, and established product companies. With accumulated project knowledge and experience with our many global client, we have helped enterprises follow or stay ahead of market trends, increase impact and remain relevant.
Gain a competitive advantage and reduce your time to market with CoreValue domain-led expert technology solutions!
R&D in action
AR Office Guide
App Idea
When a new employee comes to work, the right people are not always available to guide them through the office, and show them what they need to know. But orientation can still be facilitated through the use of a mobile device (or Hololens) that can extend walls and floors with useful statistics, geo-spotted 3D infographics, and pointers to the various office facilities.
To use Google Tango/ ARCore + Unity3D
We deliver innovation.
CoreValue is a one stop-shop for tech R&D outsourcing based in Europe, including Ukraine and Poland.


text:
A person is sick and he wants to have treatment. Now write a dialogue between a doctor and a patient.
Patient : Good evening, doctor. Could you spend me some minutes, please?
Doctor : Of course, I can.
Patient : I have been suffering from fever for few weeks.
Doctor : What are the signs of your fever? When do you feel temperature?
Patient : It is usually between 5p.m. to 6p.m.
Doctor : When does the fever remit?
Patient : At late hours of the night.
Doctor : Didn't you take any short of treatment?
Patient : I was under the treatment of a village doctor.
Doctor : Please show me the prescription.
Patient : Here it is, doctor.
Doctor : Oh! He has prescribed you wrong medicine. Let prescribe medicine for you.
Patient : Thank you very much, doctor.
Doctor : Well come.
You can also read more: Dialogue
Write Better, Get Published, Be Creative
Online Publication Opportunities for Young Writers
Digital Study Center is seeking submissions of poetry, short stories, and unique articles for publishing online to our website.
Young writers, author, and teachers are most welcome to Submit Your Writing for Publishing Assistance.


text:
Diamond Products
All Products
Diamond coated tooling offers high performance and superior cutting capability for larger diameter applications in the Aerospace, Formula 1 and Maritime industries.
The diamond coated finish ensures that the cutting edge remains sharp to prevent the fraying of fibres and the delamination of composite materials. Diamond products are traditionally used in the machining of non-ferrous materials including graphite, carbon fibre, fibreglass, plastics and ceramics.
Our diamond products are available in a range of different grit sizes to suit the finish you require. They can be used in hand held and machine based operations and can also be re-coated to increase lifespan at our re-grinding facility.


text:
I have used a topper and papers from the All Dressed Up CD again, this time I have used one of the masculine collections.
I cut the golf topper out with an oval die and created a layer of decoupage. I added distress ink to both the topper and the papers to create a more vintage feel. The sentiment is from Kraftwork cards and I made my own card candi.
Make sure you pop over to the Ooh La La Creations Challenge Blog and check out the DT inspiration, we would love for you to join us for our For a Man or Boy Challenge.
Thank you for calling today, your company is much appreciated.


text:
Professor MUKAIDA Naofumi
Faculty, Affiliation
Cancer Research Institute
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Medical Science, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Division of Molecular Bioregulation TEL:076-265-2767 FAX:076-234-4520
Academic Background
【Academic background(Bachelor's Degree)】
Hokkaido University 1980
Kanazawa University Cancer Research Instittue(2000/01/01-)
Kanazawa University Cancer Research Institute(1992/05/01-1999/12/31)
Tokyo Medical and Dental University School of Allied Health Sciences(1992/04/01-1993/04/30)
Tokyo Medical and Dental University Med. Technol. School, School Med.(1990/11/01-1991/03/31)
National Caner Institute, USA Laboratory of Molecular Bioregulation(1988/05/01-1990/10/31)
Jichi Medical School Dept. Clinical Pathology(1985/04/01-1989/04/30)
Jichi Medical School Dept. Clinical Pathology(1980/05/25-1985/03/31)
Year & Month of Birth
Academic Society
Japanese Society of Metastasis Research
Japanese Cancer Association
American Association of Immunologists
American Society of Investigative Pathology
Japanse Society of Inflammation and Regneration
Japanse Society of Inflammation and Regneration
Japanse Society of Inflammation and Regneration
Japanse Society of Inflammation and Regneration
Japanse Society of Inflammation and Regneration
Japanse Society of Inflammation and Regneration
Immunology、Laboratory medicine、Experimental Pathology、Pathological Medical Biochemistry
Speciality Keywords
Pro-inflammatory cytokines
Research Themes
Study on pro-inflammatory cytokines and chemokines in tumor development and progression
It has been well recognized that inflammatory responses have crucial roles in the development, progression, and metastasis steps of cancer. Moreover, pro-inflammatory cytokines such as tumor necrosis factor and chemokines have been presumed to be indispensable for inflammatory resposense. We are investigating the roles of pro-inflammatory cytokines and chemokines in development, progression, and metastasis processes of cancer, mainly by using mouse models.
Elucidaiton on the roles of Pim kinases in cancer development and progression
We determined the amino acid sequence of a novel serine/threonine kinase, Pim-3. We further unraveled that Pim-3 expression is observed in malignant lesions but not normal tissues of endoderm-derived organs and that Pim-3 can promote the survival of tumor cells by counteracting the activities of pro-apoptosis molecules. We are now eluciding the regulatory mechanisms underlying Pim-3 activation and expression, in order to develop a novel type of anti-cancer drugs targeting Pim-3.
Study on roles of pro-inflammatory cytokines and chemokines in iflammation.
It has been widely accepted that pro-inflammatory cytokines such as tumor necrosis factor and chemokines are crucial in inflammation. We are investigating the regualatory mechanisms underlying pro-inflammatory cytokine and chemokine expression and their pathophysiological roles in inflamamtory reactions.
- The Cytokine Handbook, 4th Edition Elsevier Science Ltd 2003/08
- Yang X, Lu P, Ishida Y, Kuziel WA, Fujii C, and Mukaida, N. Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages, and neovascularization. 118 2 335-345 2006/01
- Yang X, Lu P, Fujii C, Nakamoto Y, Gao J-L, Kaneko S, Murphy PM, and Mukaida N. Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression. 118 8 1869-1876 2006/04
- MIP-1alpha/CCL3-mediated maintenance of leukemia initiating cells in the initiation process of chronic myeloid leukemia. 265. Baba T, Naka K, Morishita S, Komatsu N, Hirao A, and Mukaida N Journal of Experimental Medicine 210 12 2661 2013/11
- Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice. Popivanova BK,Kostadinova FI,Furuichi K,Shamekh MM,Kondo T,Wada T,Egashira K,Mukaida N Cancer Res 69 19 7884-92 2009/10
- Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, and Mukaida N. JOURNAL OF CLINICAL INVESTIGATION 118 2 560-570 2008/02
- Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancer-associated fibroblast accumulation. Tanabe Y, Sasaki S, Mukaida N, and Baba T Oncotarget 7 30 48335 2016
- Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice. 269. Sasaki S, Baba T, Shinagwa K, Matsushima K, and Mukaida N International Journal of Cancer 135 6 1297 2014/03
- MIP-1alpha/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, and Mukaida N. Blood 127 21 2607 2016
- Ag and IL-2 immune complexes efficiently expand Ag-specific Treg cells that migrate in response to chemokines and reduce localized immune responses. 268. Hamano R, Baba T, Sasaki S, Tomaru U, Ishizu A, Kawano M, Yamagishi M, and Mukaida N European Journal of Immunology 44 4 1005 2014/02
- Chemokines in tumor development and progression. Mukaida N and Baba T EXPERIMENTAL CELL RESEARCH 318 2 95 2012/02
- Roles of Pim-3, a novel survival kinase, in tumorigenesis. Mukaida N,Wang YY,Li YY Cancer Science 102 8 1437-42 2011/08
- Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha. Iida N,Nakamoto Y,Baba T,Nakagawa H,Mizukoshi E,Naito M,Mukaida N,Kaneko S Cancer Res 70 16 6556-65 2010/08
- Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. Baba T,Nakamoto Y,Mukaida N JOURNAL OF IMMUNOLOGY 183 5 3053-63 2009/08
- Pivotal role of the CCL5-CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing. Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, and Kondo T JOURNAL OF CLINICAL INVESTIGATION 122 2 711 2012/01
- Absence of IFN-gamma accelerates thrombus resolution through enhancing MMP-9 and VEGF expression in mice. Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, and Kondo T JOURNAL OF CLINICAL INVESTIGATION 121 7 497 2011/07
- Gemcitabine induces cell senescence in human pancreatic cancer cell line Song Y, Baba T, and Mukaida N Biochem Biophys Res Commun 477 515 2016
- Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis Sasaki S, Baba T, Nishimura T, Hayakawa Y, Hashimoto S, Gotoh N, and Mukaida N Cancer Letters 378 1 23 2016
- High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-posisitve T cells into tumor sites Naito T, Baba T, TakedaK, Sasaki S, Nakamoto Y, Mukaida N Cancer Letters 366 1 93 2015
- Inflammatory monocytes recruited to allergic skin acquire anti-inflammatory M2 phenotype via basophil-derived IL-4. Egawa M, Mukai K, Yoshikawa S, Iki M, Mukaida N, Kawano Y, Minegishi Y, and Karasuyama H. IMMUNITY 38 3 570 2013/03
- Identification of a phenanthrene derivative as a potent anti-cancer drug with Pim kinase inhibitory activities. Wang Y-Y, Taniguchi T, Baba T, Li Y-Y, Ishibashi H, and Mukaida N. Cancer Science 13 1 107 2012/01
- Critical role of TNF-alpha-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization. Lu P, Li L, Liu G, Baba T, Ishida Y, Nosaka M, Kondo T, Xhang X, and Mukaida N INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53 7 3516 2012/07
- Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a cocomitant reduction of TNF-alpha, IL-12, and IL-18 production JOURNAL OF IMMUNOLOGY 162 2 1049-1055 1999/01
- Alleviation of monocrotaline-induced pulmonary hypertension by antibodies to monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 LABORATORY INVESTIGATION 78 5 571-581 1998/05
- Anoxia-induced up-regulation of interleukin-8 in human malignant melanoma. A potential mechanism for high tumor aggressiveness. AMERICAN JOURNAL OF PATHOLOGY 155 3 753-763 1999/09
- Activator protein (AP)-1 is the preferred transcription factor for cooperative interaction with nuclear factor (NF)-kappaB in respiratory syncytial virus-induced interleukin (IL)-8 gene expression in airway epithelium JOURNAL OF INFECTIOUS DISEASES 177 5 1275-1281 1998/05
- Anti-interleukin-8 monoclonal antibody reduces free radical production and improves hemodynamics and survival rate in endotoxic shock in rabbits. SURGERY 122 1 60-68 1997/07
- Attenuated liver fibrosis and depressed serum albumin levels in carbon tetrachloride-treated IL-6-deficient mice JOURNAL OF LEUKOCYTE BIOLOGY 66 4 601-608 1999/10
- Attenuation of monosodium urate crystal-induced arthritis in rabbits by a neutralizing antibody against interleukin-8 JOURNAL OF LEUKOCYTE BIOLOGY 62 4 444-449 1997/10
- CCR4 memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 107 353-358 2001/02
- Chemokines in the bronchoalveola lavage fluid of patients with sarcoidosis INTERNAL MEDICINE 36 12 856-860 1997/12
- Combined therapy of multidrug-resistant human lung cancer with anti-P-glycoprotein antibody and monocyte chemoattractant protein-1 gene transdcution: the possibility of immunological overcomeing of multidrug resistance INTERNATIONAL JOURNAL OF CANCER 71 2 170-177 1997/04
- Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. MOLECULAR CARCINOGENESIS 26 2 119-129 1999/10
- Delayed clearance of zymosan-induced granuloma and depressed phagocytosis of macrophages with concomitant up-regulated kinase activities of Src-family in a human monocyte chemoattractant protein-1 transgenic mouse Immmunobiology 201 3 4 432-449 2000/01
- Differential induction of JE/MCP-1 in subclones from a murine macrophage cell line, RAW 264.7 : role of kappaB-3 biding protein CYTOKINE 12 3 207-219 2000/03
- Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2 JOURNAL OF IMMUNOLOGY 166 7104-7111 2001/06
- Distinct expression of CCR1 and CCR5 in glomerular and interstitial lesions of human glomerular diseases AMERICAN JOURNAL OF NEPHROLOGY 20 291-299 2000/07
- Down-regulation of CXCR2 expression on human polymorphonuclear leukocytes by TNF-alpha JOURNAL OF IMMUNOLOGY 160 9 4518-4525 1998/05
- Effect of thromboxane A2 antagonists on bronchial hyperresponsiveness induced immediately after interleukin-8 inhalation in guinea-pigs British Jounral of Pharmacology 122 6 1015-1020 1997/11
- Elevated chemokine levels in bronchoalveolar fluid of tuberculosis patients American Jounral of Respiratory and Critical Care Medicine 155 4 1474-1477 1997/04
- Endotoxin-induced uveitis is partially inhibited by anti-IL-8 antibody treatment Investigative Ophtalmoloy and Visual Science 40 11 2465-2470 1999/10
- Enhanced AP-1 and NF-kappaB activities and stability of interleukin 8 (IL-8) transcripts are implicated in IL-8 mRNA superinduction in lung epithelial H292 cells BIOCHEMICAL JOURNAL 330 1 429-435 1998/02
- Enhanced mobilization of hematopoietic progenitor cells by mouse MIP-2 and granulocyte colony-stimulating factor in mice JOURNAL OF LEUKOCYTE BIOLOGY 62 4 503-509 1997/10
- Eotaxin contributes to renal interstitial eosinophilia Nephrology Dialysis and Transplantation 14 1 76-80 1999/01
- Essential role of transcription factor nuclear factor kappaB in regulation of interleukin-8 gene expression by nitrite reductase from Pseudomonas aerginosa in respiratory epithelial cells INFECTION AND IMMUNITY 67 8 3872-3878 1999/08
- Helicobacter pylori-dependent ceramide psoduction may mediate increased interleukin 8 expression in human gastric cancer cell lines GASTROENTEROLOGY 116 6 1330-1341 1999/06
- Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response JOURNAL OF VIROLOGY 75 6095-6106 2001/07
- Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-kappaB-binding sites of the interleukin-8 gene JOURNAL OF VIROLOGY 71 7 5692-5695 1997/07
- Human T cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-kappaB-like sites CANCER RESEARCH 58 17 3993-4000 1998/09
- Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells CANCER RESEARCH 59 22 5822-5829 1999/11
- Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter MOLECULAR AND CELLULAR BIOLOGY 17 9 5097-5105 1997/09
- IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas CLINICAL CANCER RESEARCH 7 1812-1820 2001/06
- IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2 JOURNAL OF IMMUNOLOGY 167 366-374 2001/07
- IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration JOURNAL OF IMMUNOLOGY 164 5 2769-2775 2000/03
- Impairment of endotoxin-induced macrophage inflammatory protein 2 gene expression in alveolar macrophages in streptozotocin-induced diabetes in mice INFECTION AND IMMUNITY 68 5 2925-2929 2000/05
- Induction of dendritic cell differentiation by granulocyte-macrophagecolony-stimulating factor, stem cell factor, and tumor necrosis factor alpha in vitro from lineage phenotypes-negative c-kit+ murine hematopoietic progenitor cells BLOOD 90 12 4842-4853 1997/12
- Inhibition of immature erythroid progenitor cell proliferation by macrophage inflammatory protein-1alpha by interacting mainly with a C-C chemokine receptor, CCR1 BLOOD 90 2 605-611 1997/07
- Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cell line, T98G in coculture with monocytes: involvement of monocyte-derived interleukin-1alpha EUROPEAN CYTOKINE NETWORK 9 1 47-55 1998/03
- Interleukin-8 gene repression by clarithromycin is mediated by activator protein-1 binding site in human bronchial epithelial cells American Journal of Respiratory Cellular and Molecular Biology 22 1 51-60 2000/01
- interleukin-8 inhalation directly provoke bronchoconstriction in guinea pigs ALLERGY 54 4 386-391 1999/04
- Interleukin-8 selectively enhances cytopathic effect (CPE) induced by positive-strand RNA viruses in the human WISH cell line Biochemical Biophysical Research Communication 235 3 774-778 1997/06
- Intervention in endotoxin shock by sulfatide (I3SO3-GalCer) with a concomitant reduction in tumor necrosis factor a production INFECTION AND IMMUNITY 65 4 1223-1227 1997/04
- Lipopolysaccharide-induced cytokine and receptor expression and neutrophil infiltration in the liver of osteopetrosis (op/op) mutant mice LIVER 20 465-474 2000/12
- Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45 INFECTION AND IMMUNITY 65 8 3218-3224 1997/08
- MIP-1 alpha and MCP-1 contribute to crescents and interstitial lesions in human crescentic glomerulonephritis KIDNEY INTERNATIONAL 56 3 995-1003 1999/09
- Modulation of tumor necrosis factor and interleukin-1-dependent NF-kappaB activity by mPLK/IRAK JOURNAL OF BIOLOGICAL CHEMISTRY 274 19 13077-13084 1999/05
- Molcular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastrci cancer cell lines Digestive Disease Science 43 9 Supplement 174S-180S 1998/09
- Monocyte chemoattractant protein-1 gene modification of multidrug-resistant human lung cancer enhances antimetastatic effect of therapy with anti-P-glycoprotein antibody in SCID mice INTERNATIONAL JOURNAL OF CANCER 80 5 773-780 1999/03
- Natural killer cell-dependent suppression of systemic spread of human lung adenocarcinoma cells by monocyte chemoattractant protein-1 gene transfection in severe combined immunodeficient mice CANCER RESEARCH 60 7002-7007 2000/12
- NF-kappaB activation is required for C5a-induced interleukin-8 gene expression in mononuclear cells BLOOD 93 10 3241-3249 1999/05
- Nitirc oxide-mediated modulation of interleukin-8 production by a human glioblastoma cell line, T98G, cocultured with myeloid and monocytic cell lines JOURNAL OF INTERFERON AND CYTOKINE RESEARCH 18 10 905-912 1998/10
- NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34+ cells expressing the CCR1 chemokine receptor LEUKEMIA 15 1092-1101 2001/07
- Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53 CANCER RESEARCH 61 673-678 2001/01
- Participation of endogenously produced interferon gamma in interleukin 4-meidated tumor rejection HUMAN GENE THERAPY 11 5 659-668 2000/03
- PEA3 and AP-1 are required for constitutive IL-8 gene expression in hepatoma cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279 166-171 2000/12
- Physiologic regulation of postovulatory neutrophil migration into vagina in mice by a C-X-C chemokine(s) JOURNAL OF IMMUNOLOGY 160 12 6159-6165 1998/06
- Prevention of cerebral edema and infarct in cerebral reperfusion injury by an antibody to interleukin-8 LABORATORY INVESTIGATION 77 2 119-125 1997/08
- Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8 CLINICAL CANCER RESEARCH 6 2735-2740 2000/07
- Regulation of placental monocyte chemotactic and activating factor during pregnancy and chorioamnionitis MOLECULAR HUMAN REPRODUCTION 4 4 393-400 1998/04
- Stimulation of interleukin-8 production by acidic polysaccharide from the root of Panax ginseng Immunopharmacolgy 38 3 287-294 1998/01
- Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-kB activation JOURNAL OF BIOLOGICAL CHEMISTRY 272 24 15366-15372 1997/06
- The alpha chemokine, interleukin 8, inhibits the antiviral action of interferon alpha JOURNAL OF EXPERIMENTAL MEDICINE 186 7 1077-1085 1997/10
- The differential ability of IL-8 and neutrophil-activating peptide-2 to induce attenuation of chemotaxis is mediated by their divergent capabilities to phosphorylate CXCR2 (IL-8 receptor B) JOURNAL OF IMMUNOLOGY 158 12 5927-5933 1997/06
- The immediate early gene 1 product of human cytomegalovirus is sufficient for up-regulation of interleukin-8 gene expression. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279 298-304 2000/12
- The participation of IL-8 in the synovial lesions at an early stage of rheumatoid arthritis TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 188 1 75-87 1999/05
- The role of Kupffer cells and regulation of neutrophil migration into the liver by macrophage inflammatory protein-2 in primary listeriosis in mice PATHOLOGY INTERNATIONAL 49 6 519-532 1999/06
- Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice BRITISH JOURNAL OF CANCER 81 4 647-653 1999/10
- Treatment with a monocolonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 122 207-211 2000/12
- Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis INFECTION AND IMMUNITY 65 5 1892-1898 1997/05
- Up-regulation of monocye chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy KIDNEY INTERNATIONAL 58 1492-1499 2000/10
- Urinary levels of chemokines (MCAF/MCP-1, IL-8) reflect distinct disease activities and phases of human IgA nephropathy JOURNAL OF LEUKOCYTE BIOLOGY 63 4 493-499 1998/04
- Prevention of endotoxin shock through targeting leukocyte adhesion molecules Progress in Clinical and Biological Research 397 327-334 1998
- Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1, in human hepatomas. AMERICAN JOURNAL OF PATHOLOGY 162 4 1249-1258 2003/04
- The essential involvement of cross-talk betweeen IFN-gamma and TGF-beta in the skin wound healing process JOURNAL OF IMMUNOLOGY 172 3 1848-1855 2004/02
- Essential involvement of INF-gamma in Clostidium difficile toxin A-induced enteritis JOURNAL OF IMMUNOLOGY 172 5 3018-3025 2004/03
- Aberrant expression of Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines INTERNATIONAL JOURNAL OF CANCER 114 209-218 2005
- Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu T, and Mukaida N EUROPEAN JOURNAL OF IMMUNOLOGY 36 4 1028-1038 2006/04
- Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway Ishida Y, Kondo T, Kimura A, Matsushima K, and Mukaida, N JOURNAL OF IMMUNOLOGY 176 9 1028-1038 2006/05
- Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulation of intrarenal multidrug resistance-associated protein 1 expression. Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, and Kondo T AMERICAN JOURNAL OF PATHOLOGY 169 4 1118-1128 2006/10
- Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines Li Y-Y, Popivanova BK, Nagai Y, Ishikura H, Fujii C, and Mukaida N CANCER RESEARCH 66 13 6741-6747 2006/07
- Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced anti-angiogenic factor expression Lu P, Li L, Kuno K, Wu Y, Baba T, Li Y-Y, Zhang X, and Mukaida N. JOURNAL OF IMMUNOLOGY 180 6 4283-4291 2008/03
- Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma Tsuchiyama T, Nakamoto Y, Sakai Y, Marukawa Y, Kitahara M, Mukaida N, and Kaneko S. JOURNAL OF IMMUNOLOGY 178 1 574-583 2007/01
- IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappaB activation. JOURNAL OF IMMUNOLOGY 178 11 7385-7394 2007/06
- Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation Hisatsune J, Nakayama M, Isomoto H, Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, Yamasaki E, Yashiro K, Moss J, and Hirayama T JOURNAL OF IMMUNOLOGY 180 7 5017-5027 2008/04
- A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wistar-Kyoto rats JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 11 1534-1541 2000/08
- Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice Sawanobori Y, Ueha S, Kurachi M, Shimaoka T, Talmadge JE, Abe J, Shono Y, Kitabatake M, Kakimi K, Mukaida N, and Matsushima K BLOOD 111 12 5457-5466 2008/06
- CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fiborblasts, and promotes angiogenesis in murine lung metastasis process. JOURNAL OF IMMUNOLOGY 181 9 6384-6394 2008/11
- Gemcitabine-induced CXCL8 expression counteracts its action by inducing tumor neovascularization Song Y, Baba T, Li Y-Y, Furukawa K, Tanabe Y, Matsugo S, Sasaki S, and Mukaida N. Biochem Biophys Res Commun 458 2 341 2015
- IFN-gammais protective in cisplatin-induced renal injury by enhancing autophagic flux. Kimura A, Ishida, Y, Inagaki M, Nakamura Y, Sanke T, Mukaida N, and Kondo T KIDNEY INTERNATIONAL 82 10 1093 2012/10
- CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto K, Ginsberg HN, Mukaida N, Kaneko S, and Ota T. DIABETES 61 7 1680 2012/07
- Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver. Wu Y,Wang YY,Nakamoto Y,Li YY,Baba T,Kaneko S,Fujii C,Mukaida N ONCOGENE 29 15 2228-37 2010/08
- Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice. Kostadinova FI,Baba T,Ishida Y,Kondo T,Popivanova BK,Mukaida N J Leukoc Biol 88 1 133-43 2010/07
- Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability. Li YY,Wang YY,Taniguchi T,Kawakami T,Baba T,Ishibashi H,Mukaida N Int J Cancer 127 2 474-84 2010/02
- Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice. Nosaka M,Ishida Y,Kimura A,Kuninaka Y,Inui M,Mukaida N,Kondo T J Clin Invest 121 7 2911-20 2011/07
- Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney. Shimizu K,Furuichi K,Sakai N,Kitagawa K,Matsushima K,Mukaida N,Kaneko S,Wada T Hypertens Res 34 6 747-52 2011/06
- Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice. Kakinoki K,Nakamoto Y,Kagaya T,Tsuchiyama T,Sakai Y,Nakahama T,Mukaida N,Kaneko S J Gene Med 12 12 1002-13 2010/12
- Protective roles of CX3CR1-mediated signals in toxin A-induced enteritis through the induction of heme oxygenase-1 expression. Inui M,Ishida Y,Kimura A,Kuninaka Y,Mukaida N,Kondo T J Immunol 186 1 423-31 2011/01
- Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization. Nakamoto Y,Mizukoshi E,Kitahara M,Arihara F,Sakai Y,Kakinoki K,Fujita Y,Marukawa Y,Arai K,Yamashita T,Mukaida N,Matsushima K,Matsui O,Kaneko S Clin Exp Immunol 163 2 165-77 2011/02
- Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice. Fujii H,Baba T,Ishida Y,Kondo T,Yamagishi M,Kawano M,Mukaida N Arthritis Rheum 63 1 96-106 2011/01
- Nitric oxide-induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells. Seo JY,Yu JH,Lim JW,Mukaida N,Kim H J Physiol Pharmacol 60 Suppl 7 101-6 2009/09
- The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation. Kimura A,Ishida Y,Wada T,Hisaoka T,Morikawa Y,Sugaya T,Mukaida N,Kondo T Am J Pathol 176 1 40-50 2010/01
- Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist. Lu P,Li L,Liu G,Zhang X,Mukaida N Invest Ophthalmol Vis Sci 50 10 4761-8 2009/10
- Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization. Lu P,Li L,Liu G,van Rooijen N,Mukaida N,Zhang X Cornea 28 5 562-9 2009/05
- Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells. Li YY,Wu Y,Tsuneyama K,Baba T,Mukaida N Cancer Sci 100 3 396-404 2009/03
- Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist. Ishibe T,Kimura A,Ishida Y,Takayasu T,Hayashi T,Tsuneyama K,Matsushima K,Sakata I,Mukaida N,Kondo T Lab Invest 89 1 68-79 2009/01
Conference Presentations
Arts and Fieldwork
○Stemonamide synthesis intermediates and pharmaceutical composition for prevention and/or treatment of cancer(country:Japan, United States of America)
Theme to the desired joint research
○Anti-inflammatory therapy targeting chemokines
○Anti-tumor therapy targeting chemokines
○Screening of genes expressed selectively in chronic liver injury
○Development of a novel type of anti-cancer drug targeting a novel serine/threonine kinase, Pim-3
Grant-in-Aid for Scientific Research
Classes (Bachelors)
Classes (Graduate Schools)
○Seminars on Cytokines(2017)
○Seminars on Cytokines(2017)
○Molecular Oncology(2017)
○Seminars on Cytokines(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Biology of Cancer 2A(2017)
○Cancer molecular pathology 2(2017)
○Biology of Cancer 2B(2017)
○Cancer molecular pathology 2(2017)
○Medical Sciences(2016)
○Seminars on Cytokines(2016)
○Seminars on Cytokines(2016)
○Seminars on Cytokines(2016)
○Biology of Cancer 2A(2016)
○Biology of Cancer 2B(2016)
○Molecular Oncology(2016)
○Cancer molecular pathology 2(2016)


text:
The FIO was established under Subtitle A of Title V of the Dodd–Frank Wall Street Reform and Consumer Protection Act (the 'Dodd-Frank Act').[1] Subtitle A, also known as the Federal Insurance Office Act of 2010, authorizes the FIO to, among other things:
- Monitor all aspects of the insurance industry and identify gaps in the regulation of insurers that could contribute to a systematic crisis in the industry or the U.S. financial system as a whole;
- Monitor the extent to which traditionally underserved communities and consumers, minorities, and low to moderate-income persons have access to affordable insurance products;
- Assist in administering the Terrorism Insurance Program of the U.S. Treasury Department;
- Coordinate federal efforts and develop federal policy on aspects of international insurance matters;
- Consult with the states and state insurance regulators regarding insurance matters of national importance and prudential insurance matters of international importance; and
- Perform such other related duties and authorities as may be assigned to the Office by the Treasury Secretary.[2]
Among other things, the Federal Insurance Office is authorized to monitor all aspects of the insurance industry and identify potential gaps in insurance regulation.
The FIO Director is also an advisory member of the Treasury's Financial Stability Oversight Council established under the Financial Stability Act of 2010.
The FIO's mandate to identify 'gaps' in the state-based insurance regulatory system opens the door to more federal regulation of insurance.While the Federal Insurance Office Act of 2010 states that it is not intended to establish or provide the FIO or the Treasury Department with general supervisory or regulatory authority over the business of insurance, the FIO's mandate to monitor the insurance industry and identify 'gaps' in the current state-based system opens the door to additional federal regulation of the business of insurance.[3]
Although the FIO is still in the formative stages, the Treasury Department created the Federal Advisory Committee on Insurance in May as one in a series of steps it is taking to establish the new Federal Insurance Office created by the Dodd-Frank Act.
According to Deputy Treasury Secretary Neal Wolin, the staff of the new FIO has already begun work. In written testimony before the Senate Banking Committee on May 12, 2011, Wolin indicated that the FIO staff 'has served an important consultative role in advising on several Dodd-Frank studies, rule writing processes and ongoing responsibilities' as well as 'providing expert advice on the Volcker Rule study and rule writing, Orderly Liquidation Authority rule writing and participating in the FSOC insurance working group.'[4]
2. Federal Insurance Office Act of 2010, Sec. 503; 31 USC 313(c).
3. Federal Insurance Office Act of 2010, Sec. 503; 31 USC 313(k).
4. Deputy Secretary Neal S. Wolin Written Testimony Before the Senate Committee on Banking, Housing, and Urban Affairs, May 12, 2011.


text:
*** PRICING - click the above "PRICING" tabClick TWICE on above furniture for larger viewing
Factory Direct + FREE Nationwide* In-Home Delivery + NO tax
Comfort Design Ausie Sofa Sleeper
Item # CL4054-DQSL/EQSL
by Comfort Design Furniture of Asheboro, NC
American made leather sofa sleeper
Leather shown Hesterfield Cobblestone
Matching sectional sofa sleeper loveseat chair ottoman
Options: wood color, seat cushion style
Highest quality American made:
- Handmade with your selections - see below
- 6 to 10 weeks Factory direct into your home
- Lifetime warranty: frame, springs, manual recliner
- Steel spring seat support
- Durable layered hardwood frame
- Mortise & Tenon joints with corner block construction
- 100% top-grain Aniline leather - see below
- Dreamquest innerspring mattress, optional memory foam
Comfort Design Ausie Sofa Sleeper CL4054-DQSL/EQSL
81″W 40″D 37″H seat 70″W 22″D 21″H arm 24″H open 93″ 135LBS
Mattress Description
100 Leather Color Options
Wood Color Options
Nail Color Options
Cushion Options
Construction Methods
REVIEWS - Better Business Bureau
REVIEWS - Google
REVIEWS - This website
Frequently Asked Questions
Leather Furniture Information
Shipping - Delivery - Tax
Comfort Design Ausie Sofa Sleeper
The Comfort Design Ausie Sofa Sleeper (shown in Hesterfield Cobblestone leather) is made in North Carolina by Comfort Design. Two very comfortable queen size mattresses to choose from, please see above. A beautiful clean contemporary design with fine tailoring, welting and track arms. The plush loose backrest cushions are comfortable and supportive. A Down Feather Blend seat cushion is standard and includes down feathers on the top of the seat cushion offering a softer but supportive cushion. A Posture Plush seat cushion without feathers is available, see above. Select from over 120 top-grain aniline dyed leather colors, all premium quality cow hides. Select the wood finish color for the hardwood legs, see above. The Ausie Sofa is made with American quality and built to last 20+ years and still be comfortable and look great. This will become the most favorite place to sit in the room.
The Comfort Design Ausie Sofa Sleeper CL4054-DQSL/EQSL is made in America. It is made with your order selections by leather artisans with Comfort Design who specialize in reclining and stationary leather furniture. Comfort Design is a premium quality leather furniture manufacturer located in Asheboro, NC.
Includes FREE factory direct nationwide* shipping from NC to you with free in-home delivery and no additional sales tax is required by us.
PRICING – click the "PRICING" tab above and enter your email address or call 800-603-7133.
The Comfort Design Ausie Sofa Sleeper 4054 is handmade to your order specifications, therefore changes, cancellations and returns are not available once production is scheduled.
Leather Furniture USA


text:
Vietnam's lychee season runs for just six weeks, but with more than 60 per cent of the country's crop exported to China, political tensions between the two nations can lead to a volatile trading season, reports Agence France Presse (AFP).
Last year saw political tension rise over China's building projects on islands in disputed territories in the South China Sea, which had implications for fruit trade, with some traders in Vietnam telling AFP that lychee consignments were left to rot at borders.
This season, Vietnamese exporters are looking to diversify their lychee markets, with Australia, France and the US open to Vietnamese lychees for the first time.
"Vietnam could have a real breakthrough in the export of lychees in coming years," Mau Xuan, CEO of exporter Red Dragon told AFP, adding that there are opportunities to build exports to the US and Australia if Vietnamese exporters focus of food security and meeting the high standards for fresh produce in the two countries.
First lychees arrive in Australia
The first shipments of Vietnamese lychees arrived in Australia on 12 July, after gaining access in May, 12 years after the Vietnamese industry first applied for access.
"It is terrific that Australian consumers will have the opportunity to try these delicious fruit during the 2015 season," said Hugh Borrowman, Australian Ambassador to Vietnam. "I am sure that they will enjoy this high quality and flavoursome product - just like Vietnamese consumers enjoy eating Australian fruits such as table grapes, citrus and cherries."