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IT Development Spain is also an all-round advertisement agency.
Graphic appearance of your company´s web pages
Well functioning and imposing web pages are your company´s calling card to the entire world just like your advertising is in any other form of media!
We execute the graphic appearance and outlook of your company in a tailor-made manner and in such way that the photo material is especially optimated to be used in the Internet.
If your company´s web pages seem to download slowly it can be due to the fact that your web pages contain too much of too "bulky" graphic material unsuitable to the browser in use.
In addition to carrying out the graphic optimization we can also execute the best possible visibility for various search engines whilst ensuring the penetration of your web pages no matter what different standards require. Get in touch with us and ask us how we could renew your web pages.
Printed material
In addition to apparent graphics present in the Internet, we also produce graphic designs to diverse printed matter, whether it would be a newspaper advertisement, flyer, business card, poster or any other graphical material.
Our graphic designs are carried out in a comprehensive manner and should your company be in need of a renewal of its image or you are just about to start, we can design your graphic appearance in its entity including your company´s logo, various trade and brand marks together with letter templates etc.
By centralizing your advertising agency necessities with us you can be sure that your company has a consistent appearance and look in all forms of media. It also means that all made material is in one place only and that it will always be safeguarded and stored for later use.
We support all general graphic formats and are able to produce your photographic material in such a way that it is ready to be taken to print in CMYK 4-colour separation format or as an RGB-picture ready to be inserted in its optimated form into your company´s web pages. We can dispatch the material directly to the newspaper of your choice or to the printing house or copy shop.


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The Drive To Drink
Childhood tends to be remembered as a menagerie of cars and houses, and mine was no different. When I was a kid, we went through several different cars. We had a Ford Grenada, a Ford Pinto, an MG Spitfire, a Porsche 914, Buick Regal, a Renault, a Camaro and a Cadillac. We drove everywhere in these cars, from Memphis to the Gulf Coast and Chicago, to Pickwick and Sardis, countless trips to my grandparents' and great-grandparents' houses, to Montesi's, Central Hardware, downtown to take my father to work and to the liquor store. My dad went to the liquor store a lot, though we kids had to stay in the car while he ran in. I never knew what went on behind the doors of the liquor store. In my mind there were naked women dancing around. Seriously. That's what was taboo in my prepubescent head – nudity. It couldn't simply be that there was booze in there, because there was booze everywhere. It was also the 70s and must have been safer to leave your two or three kids in the car with the windows down while you ran in for a bottle of scotch or rum or gin.
Tonight, on the way home from work, I had one of The Quartet with me and needed to stop by the liquor store for a bottle of wine. I debated with myself the whole way there as to whether or not he should come in with me. I didn't see any reason why not, but something told me he shouldn't, not because I think a liquor store is some sort of den of iniquity, but simply because I wasn't allowed to at his age so neither should he. I silently talked to myself the whole way there about the situation, shaking my head and shrugging just the way my mother does, and finally decided, as I pulled into the parking lot, that he should stay in the car. I have no good reason for that. More reason, in fact, for him to come in with me, what with all the crazies out there eyeing my 1991 Volvo 740 wagon. The car could easily be taken with one of The Quartet in it. I really questioned my decision when I got out of the car and was immediately panhandled by one of our quaint, Midtown denizens. But I'd parked right in front of the store, had locked the doors and could see the car the whole time from the Pinot Noir display and the front counter.
So the trip ended safely and neither the car nor the kid were stolen. The kid barely escaped a visit to Gomorrah and I was left with a nice bottle of wine and the nagging disappointment, as an adult, that there are no naked girls dancing behind the door of a liquor store.

subset: commoncrawl


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Paphos (Cyprus)
Cruise Port schedule, live map, terminals, news
West Coast USA and Canada
Local Time
2020-04-05 16:36
5 m/s
Paphos is a port town in southwestern Cyprus Island (Greece) with population around 33,000 and served by the international Paphos Airport (located approx 7 km / 4 ml southeast of the town). Paphos is on the Mediterranean coast, and approx 50 km (31 ml) west of Limassol (Cyprus Island's largest seaport) connected via A6 highway.
In terms of international trade, Port Paphos is not important as most shipping operations are via Limassol. Paphos Marina has historical and cultural importance and is largely used for fishing. The harbor has a small marina (providing mooring for yachts and pleasure boats) and a fisherman shelter (with capacity 300 boats).
Local economy is largely based on tourism. Nearby are located 4 premium resorts (Aphrodite Hills, Coral Bay, Kato Paphos, Latchi), of which Kato Paphos is the largest (employing over half of city's population). Another major industry is farming - especially grape, banana, tobacco, with vast water distribution network irrigating around 5000 hectares (50 km2).
Paphos has Cyprus Island's second biggest airport (after Larnaca). Paphos Airport (civil-military, opened in 2012) is located approx 7 km (4 ml) southeast of the town. The airport is mainly used by foreign and Greek tourists vacationing in western Cyprus. A dedicated 4-lane road links the airport with the town to avoid congestions on roads B6 and E603 during peak-summer season. The airport has as facilities 7 gates, 22 aircraft stands, bars, restaurants, cafes, bank, duty-free shop, gift shop, tourist info desk, car rentals, refrigerated storage facilities. Almost all international flights are seasonal, linking to large airports in the UK, Ireland, Belgium, Denmark, Switzerland, Poland, Russia, Germany, Holland, Finland, Estonia, Israel, Egypt.
Near Old Paphos (Palaepaphos) is the birthplace of Aphrodite - Greek goddess of beauty and love. Old Paphos was the most important place for Aphrodite worship in the ancient world. The New Paphos was nominated "2017 European Capital of Culture" - along with Aarhus Denmark. Paphos was once Cyprus' only traffic-free city. However, things changed after urbanization and the rise of population in less than 10 years. The problem is mainly in downtown, where the tight roads can't serve the hugely increased traffic.
Paphos cruise terminal
As cruise port, Paphos is visited mainly by smaller-sized luxury ships and megayachts. Larger cruise liners anchor at sea and transport their passengers to Paphos Harbour via their tender boats. Cargo vessels and passenger (ferry and cruise) ships usually dock at Port Limassol (approx 60 km / 37 ml away).
A new (large) marina is planned to be built approx 10 km (6 ml) north of Paphos - next to Coral Bay. The new yacht marina is with planned max capacity 1000 slots.
Port Paphos cruise ship schedule shows timetable calendars of all arrival and departure dates by month. The port's schedule lists all ships (in links) with cruises going to or leaving from Paphos, Cyprus. To see the full itineraries (ports of call dates and arrival / departure times) and their lowest rates – just follow the corresponding ship-link.
|28 May, 2020
|Oceania Sirena
- Cruise Industry
Alexandria Port Welcomes First Cruise Ship from Cyprus After 10-Year Hiatus
Port Alexandria (Egypt) welcomed on Saturday, October 19, its first cruise ship between Egypt and Cyprus following a 10-year halt. The Salamis...October 21, 2019
- Accidents
VIDEO: Passenger Medevaced from Crown Iris
A cruise passenger with serious health problems has been airlifted by Cyprus rescue services and transported to Paphos hospital early Monday, July 22...July 22, 2019
- Cruise Industry
Docking Cruise Ship Facilities in Paphos Tabled
The building of a pier for the docking of cruise ships is due to be incorporated into a study to be conducted for Port Paphos' marina. The proposal...July 10, 2019
- show more news


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Our house is located far away from the noisy everyday hustle, surrounded by carefully tended Apple orchards.
Let yourself be enchanted by the beautiful alpine atmosphere Of the Venosta valley, relax in the summer months at the house own outdoor Swimming pool with the beautiful lawn sunbathing area,
And enjoy the magnificent panoramic view of the Magnificent Venosta valley.
Our apartments are equipped with all cooking Utensils, dishes, cutlery, pots and pans, nice balcony, bathroom with shower/toilet, Livingroom with extra sofa bed. TV LED 32"inches and free wireless Internet Access. Washmachine on request.
Open all year. 1 parking space available.


text: RAISE FUNDS FOR YOUR YOUTH PROGRAMIBC Youth Development has partnered with Sixlets and their fundraising brand, Niagara by Frey, to provide bowling center and USBC associations an opportunity to raise money for their youth bowling programs. Fundraising is not new to bowling, but this is a chance to have a national fundraising program customized for your association or center. This program can help you raise money to support your youth programs with: Shirts Travel expenses Tournament entries Scholarship Check out the program and then contact Sixlets to setup an account and start raising money for your youth bowling program. See program flyer here.See Fundraiser Packet here.CONTACT Theresa CottrellFundraising Account ManagerSweetWorks Confections LLC, A Chocolat Frey Company3500 Genesee StreetBuffalo, NY 14225Phone: 716-634-0880 x 104Toll Free: 800-234-5750Fax: 716-634-4855Cell: 716-208-1760E-mail: firstname.lastname@example.com


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Recruitment and retention of direct care workers is a top concern for skilled nursing and assisted living providers nationally. An increased demand for services due to an aging population and a declining supply of individuals seeking and maintaining careers in this profession are factors responsible for a looming workforce crisis. It will take a significant effort to attract, recruit and retain skilled workers.
IHCA/INCAL is dedicated to supporting members in their efforts to find and train quality staff. Learn more about the assocation's workforce development offerings and how they might be of use to you!
Certified Nurse Aides (CNAs) fill the most hands-on role in resident care and are integral to the care process. CNA positions also represent the highest number of vacancies and rate of turnover in skilled nursing and assisted living. Identify onsite CNA training programs in your area and explore a new online training program from IHCA/INCAL and partner Academic Platforms. Learn More.
IHCA/INCAL is partnering with EmployIndy to establish a registered apprenticeship program to be implemented in skilled nursing and assisted living centers across Marion County. Apprentices are guided through the program by an experienced mentor and receive progressive wage increases. Healthcare providers that partner with EmployIndy may be able to take advantage of financial reimbursements for wages and training costs associated with hiring individuals into a registered apprenticeship program. To learn more, view this webinar on the apprenticeship program.
Carefortheaging.org provides information on a range of careers available at skilled nursing and assisted living facilities throughout Indiana, including education requirements, salaries and paths for career advancement. The website also links individuals seeking educational opportunities, internships or job placements with facilities looking to fill those roles. Learn More.
The Job Bank is a free resource for IHCA/INCAL members to post open staff positions. Potential job applicants can also post their resumes through the Job Bank. Learn More.
The Indiana Health Care Foundation (IHCF) awards education and training scholarships for professionals in clinical, medical, and administrative positions in long term care. Learn More.
Unsure what the best long term care option is for your loved one? Visit the LTC Resources page to decide what best meets their care needs.
Whether you're seeking care for yourself, or for a loved one such as a spouse, parent or sibling, Care Conversations connects you with advice from long-term care professionals to help you every step of the way.
Note: Non-members may receive communications about education opportunities. Legislative updates and regulatory alerts are a member benefit.
Indiana Health Care Association
One North Capitol, Suite 100
Indianapolis, IN 46204
Phone: 800-466-IHCA
Fax: 877-298-3749


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We recently took a trip to the Torrey Pines Gliderport, located across from UCSD, just next to the Pacific Ocean, in La Jolla, California. It had been a long time since our daughter and I had been there, and realized that my husband and our sons had never visited it prior.
It's a super fun place to take the family and watch paragliders and hang gliders sail above the rugged bluffs above the beach. The view of the ocean and surrounding area is absolutely spectacular! It's really relaxing with the coastal breeze and relaxed atmosphere, and makes for a unique and memorable day trip. It's the type of place that helps you appreciate the natural beauty of life.
We visited on a Sunday afternoon, and it was pretty busy with paragliders coming and going. We found a nice viewing area, and enjoyed watching them take off, fly, and land. There were probably more than twenty paragliders flying in and out, relaxing on the grass, and repeating it all again.
Soon after we arrived we saw a man landing his paraglider with a dog in tow. The kids couldn't believe it! We were pretty surprised too! The dog didn't look the least bit nervous, as if it was part of his/her daily routine. We found out that there are actually a lot of "flying dogs" that are regulars at the Gliderport.
There's no fee to visit or park at the Torrey Pines Gliderport. If you go, be sure to obey the signs, and stay off the grassy area reserved for those permitted to fly. Aside from the hang gliders and paragliders you might see model RC planes (remote control) and Sail Planes as well. There's an on-site restaurant, and lots of tables with benches for seating. They sometimes host special events, such as car shows, and according their website they have live music every Saturday afternoon from 1pm-4pm.
Although our kids don't have the interest (yet!), according to their website, tandem flights are available for "any age". We viewed images of kids as young as age 3 flying! Pretty amazing!
We recommend you wear comfortable walking shoes, bring a hat, sunglasses, and sunscreen when visiting the Gliderport. If you have the interest, there are some nice hiking trails with easy access from the same area. If you go hiking, be cautious of snakes.
A few weeks after we visited the Gliderport a handful of my friends took their first paragliding flights there. I loved watching their videos, getting the perspective of someone in the air. Here are links to a few of their adventures:
• Dariela Dives Into The World of Hang Gliding
• LaLa's High Flying Adventure
• Becky Soars Above The Pacific
Here's a LINK to the Torrey Pines Gliderport website, where you can find more info about tandem flights and more. As mentioned, it's a beautiful location, and lots of fun to visit with the family. Perhaps we'll see you there!


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Pumpkin Heads
Our two little pumpkin heads - Poppy and Soren - seem to be settling into their new routines now, and really have become good playmates/friends. They invent little games that they like to play together, and run around the house playing hide and seek and 'touch', aka 'tag'. Our house feels full of love and busyness, and for the first time in their lives they can play and create without me there with them. While I'm in the kitchen they will disappear upstairs, and later I will find some half-done puzzles or a destroyed fort.
Both of them seem to be making strides making their own friends as well. Soren went to a friends house after school today, and Poppy tells us stories about her various school friends. When she meets a new kid at a playground or somewhere, she will say 'hi, I'm Poppy', and then shortly after introduce them to her brother Soren.
I volunteered in a kindergarten classroom last week, and it's so interesting to see how different kids are in terms of their development. Even physically, some kids are tiny while others look like they could be 7 or 8. One child was clearly the class helper - she seemed so capable and just took on roles like setting the table for snack, or helping other kids zipper their zippers and tie their shoes. It was nice to get to see Soren's 'world', and he was so excited to show me all of their routines and activities. And now I'm off to work on halloween costumes... I have known what the kids were being for months, and true to form, have procrastinated till the last moment. Time to get out the sewing basket and the glue gun!
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I found these glass beads at Michael's. Full price they are 99 cents. They come in different sizes, and it took me 3 strands (so three dollars), plus some ribbon, fastenings, and wire.
To both sides I added a jump hoop again.
Last in the bead line up is this bracelet, also using traditional beads from parades. I posted that tutorial on Monday.


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ALL donations matched until further notice!
ALL Donations Matched!
Your donation will help more than the NCVRC. It will allow a Veteran or family member to discover their sense of purpose, worth, and become successful after serving our Nation.
If you would like to donate, click the "donate now" button below to use PayPal or you can send a check to 4650 W. 20th St, Greeley, CO, 80634 made to the Northern Colorado Veteran Resource Center.
Your donation will be matched dollar for dollar making your support have an even bigger impact. Thank you!
Without the support of the Community and donors. The Northern Colorado Veteran Resource Center would not be able to operate at the level needed to serve our Veterans efficiently and effectively. We are a local non profit located in Greeley. Veteran Services are accessible to our Veteran community due to your support. Send us an email if you are interested in contributing.
Looking to get involved in the community? We have many different opportunities for Volunteers of all backgrounds. Send an email here for more information.
If you are a small business, individual, or corporate organization who would like to make more than one contribution. We have sponsorship packages for various levels. Please contact us here for more information.


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The guys on 'The Big Bang Theory' have a very fun and playful work dynamic, often joking around with each other and playing games. Because they work at CalTech, most of their jokes revolve around astrophysics and Wolowitz's lack of a PhD!
At my job, we rely on having fun and joking with one another to get through our work day! I personally get picked on for saying "dumb" things occasionally... I guess I am known for speaking before I think! Others that I work with have certain quirks, and we all constantly pick on each other through out the day. Anything to bring on a smile and pass the time until the end of the work day. Oh, and we actually get some work done while we are there, too!
You can pre-order your copy of The Big Bang Theory: Season 4 here!
I have been hired by Warner Bros. WBWord division to promote The Big Bang Theory Season 4 on DVD.


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Mental health
|Submitted By:
|Alan Heeney
|Prayer Request:
|Dear St Martin,
Please help me to have some peace of mind so that I can keep going in my job and live a quiet peaceful life. Amen Alan
* Prayers submitted through the Prayer Request Form will be moderated prior to publishing, to ensure the bona fides, as best as possible, of the submitter are genuine. St Martin Apostolate reserves the sole right to select/list prayer requests on this website.


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High Court of Madras
Case Details
Case Law Search
Lakshmi Ammal v. Thillai Natarajamurthi - S.A.No.1940 of 1989 [2002] RD-TN 697 (13 September 2002)
S.A.No.1940 of 1989
Lakshmi Ammal ... Appellant -Vs-
Thillai Natarajamurthi,
Kadiyapattinam Village,
Kalkulam Taluk,
Kanyakumari District. ... Respondent For Appellant: ... Mrs. Chitra Sampath
For Respondent: ... Mr.K. Sreekumaran Nair
This second appeal is filed against the judgment and decree dated 2 9-8-1989 made in A.S.No.5/87 on the file of the Subordinate Judge, Padmanabhapuram.
The defendant in O.S.No.350/83 on the file of the Principal District Munsif, Padmanabhapuram, is the appellant in the second appeal. The respondent herein filed the suit for redemption, partition and future profits on the following averments:
The suit property belonged to him and his deceased brother Subbian Chettiar. Subbian Chettiar sold his rights to the appellant/ defendant. On 10-10-1122 M.E., corresponding to 24-5-1947, the plaintiff executed an othi in favour of one Bagavathi Amma. On 11-11-1124 M.E., corresponding to 25-6-1949, the defendant obtained an assignment from Bagavathi Amma. The plaintiff is an agriculturist. The first item is agricultural land. The second item is garden land. As per Act 4 of 1938, the othi debt got fully discharged on 10-11-1154 M.E., corresponding to 25-6-1979. The plaintiff has become entitled to recover possession of the property. As he had 30 years for filing the suit, the suit was in time. The plaintiff could get redemption of the othi as per Oodukur rights. The plaintiff through his Power of Attorney Holder, suggested to the defendant on 27-2-1983 to have a settlement. The defendant not having accepted the suggestion, the suit came to be filed. Till the property is given back to the plaintiff, he is entitled to mesne profits.
2. The defendant resisted the suit contending inter alia as follows:
The plaintiff has no right over the suit properties. The plaintiff's brother deceased Subbian Chettiar sold the entire suit properties in favour of the defendant. The sale was on behalf of the plaintiff also. He also accepted the same and did not question it in any Civil Court within the period of limitation. The defendant is in possession of the suit property, after redeeming the earlier mortgage and his possession is that of a jenmi. In any event, the suit is barred by limitation as well as by adverse possession.
3. There were other defences raised, but for the purpose of disposing of the second appeal, they are not relevant.
4. The trial Court framed the necessary issues and on the oral and the documentary evidence, held that the plaintiff was an agriculturist entitled to the benefits of Act 4 of 1938, that the mel-othi as pleaded by him, was true and that the defendant had not prescribed for title by adverse possession. In short, the learned District Munsif held on all issues in favour of the plaintiff and by judgment and decree dated 10-12-1986 granted the plaintiff's prayer.
5. The defendant filed appeal in A.S.No.5/87 before the Subordinate Judge's Court, Padmanabhapuram. The learned Subordinate Judge, by judgment and decree dated 29.8.1989 confirmed the decision of the trial Court and dismissed the appeal.
6. It is as against that, the present second appeal has been filed. At the time of admission, the following substantial question of law was raised for decision in the second appeal:
"Is not the possession of the defendant adverse to the plaintiff by reason of Exs.B-2 and B-3 sales and the title of the plaintiff lost by adverse possession?"
7. Mrs. Chitra Sampath, learned Counsel for the appellant, submitted that: the plaintiff came forward with a definite case that the defendant was an assignee of the suit mortgage dated 10-10-1122 M.E. and she failed to establish the same and therefore, the suit for redemption against her was not maintainable; the Courts below were in error in relying on Ex.A-4 written statement in an earlier suit O.S.No.622/81, in which, according to the plaintiff, the defendant had admitted about the assignment; in any event, the Courts below ought to have held that from the dates of sale under Exs.B-2 and B-3 in 1970, the defendant must be deemed to have been in possession of the properties and prescribed for title by adverse possession; even otherwise, from the date of the alleged assignment, viz. 25-6-1949, the period of 30 years prescribed under the Limitation Act for redemption expired in 197 9 and the suit having been filed only in 1983 was barred by limitation.
8. Per contra, Mr. Sreekumaran Nair, learned Counsel for the respondent, submitted that the Courts below have concurrently found that there was an assignment in favour of the defendant, that the plaintiff was an agriculturist entitled to the benefits of Act 4 of 1938 as amended by Act 8 of 1973 and limitation if at all, would commence only from the date of coming into force of the Amendment Act 8 of 1973, on which date it must be deemed that the debt stood discharged.
9. In this connection, the learned Counsel relied on the judgment of S. NATARAJAN, J. in GNANAMMAL VS. ELAYAPERUMAL NADAR AND OTHERS (19 76(2) MLJ 269).
10. The learned Counsel for the appellant sought to distinguish the case relied on by the learned Counsel for the respondent, stating that the facts in that case were entirely different from the facts of the present case and therefore, the ratio of that decision would not apply.
11. From the above submissions the following additional substantial question of law arises for consideration: "Whether the suit filed in 1983 more than 30 years from the date of mortgage in 1947 or assignment in 1949 is in time?"
12. As already noted, the Courts below found that the plaintiff was an agriculturist entitled to the benefits of Act 4 of 1938, as amended by Act 8 of 1973. Under the said Act, Section 9-A.(5)(a) provides that,
"where the mortgagee has been in possession of the whole of the property mortgaged to him for an aggregate period of thirty years or more, then notwithstanding anything contained in Sections 8, 12 and 13, the mortgage debt swhall be deemed to have been wholly discharged with effect from the expiry of the period of thirty years or where such period expired before the publication of Tamil Nadu Agriculturists Relief (Amendment) Act, 1973 in the Tamil Nadu Government Gazette with effect from the publication of that Act - (i) if no interest has been stipulated for on the principal amount secured by the mortgage or any portion thereof, in addition to the usufruct from the property;
(ii) where such interest has been stipulated for, if no arrears of interest are due from the mortgage; and
(iii) if no other sums or interest thereon are due to the mortgagee by the mortgagor in his capacity as such."
13. In paragraph 17 of the judgment of the lower Appellate court, the learned Judge had referred to the concession made on behalf of the appellant that the plaintiff was an agriculturist. If the plaintiff was an agriculturist, then by virtue of the provisions of the Act already referred to and in view of the possession of the property by the mortgagee for a period of 30 years and more, the entire debt must be deemed to have been discharged.
14. The only point surviving for consideration therefore is as to when the period of limitation would commence. According to the learned Counsel for the appellant, the period must be deemed to have expired in 1979 and the suit having been filed only in 1983, was clearly barred by limitation.
15. Incidentally, the point has been raised by the learned Counsel that the plaintiff had not proved the assignment. There was an earlier suit filed by the plaintiff's brother Subbian Chettiar's son Ayyappan and others against the present plaintiff and others. The present defendant was the third defendant in that suit. In the written statement in that suit, this is what he had stated:
"Half of suit item 1 was mortgaged by the first defendant (the present plaintiff) to a stranger and by change of hands, the third defendant got mortgage right and possession. The said mortgage became barred by limitation and the third defendant became the absolute owner. The father of plaintiffs 1 and 2 sold his entire right in suit item 1 to the third defendant for valid consideration and family necessity on 21-2-1970, and accordingly, the third defendant is in possession of the same. She is the owner of the entire suit item 1."
16. There can be no clearer admission of the assignment in favour of the present defendant. The defendant is therefore estopped from disputing that she became an assignee of the othi by the plaintiff on 1 0.10.1122 M.E. (24-5-1947). The assignment pleaded is dated 11.11.11 24 M.E. (25-6-1949). We have therefore to see whether the suit filed in 1983 was in time.
17. It is in this connection, the learned Counsel for the respondent relied on the judgment in GNANAMMAL VS. ELAYAPERUMAL NADAR AND OTHERS (1976(2) MLJ 269). Before going into the details of that case, let us refer to the provisions of the Transfer of Property Act, with particular reference to usufructuary mortgage. Section 62 of the Act provides as follows:
"Right of usufructuary mortgagor to recover possession: In the case of a usufructuary mortgage, the mortgagor has a right to recover possession of the property together with the mortgage deed and all documents relating to the mortgaged property which are in the possession or power of the mortgagee, -
(a) where the mortgagee is authorised to pay himself the mortgage money from the rents and profits of the property – when such money is paid; (b) where the mortgagee is authorised to pay himself from such rents and profits or any part thereof a part only of the mortgage money, - when the term (if any), prescribed for the payment of the mortgage money has expired and the mortgagor pays or tenders to the mortgagee the mortgage money or the balance thereof or deposits it in Court as hereinafter provided." The relevant Article under the Limitation Act is Article 61(a). It provides a period of 30 years to the mortgagor to redeem or recover possession of immovable property mortgaged from the date, right to redeem or to recover possession accrues.
18. In the instant case, the right to redeem or to recover possession must be deemed to have accrued only from the date the mortgagee completed 30 years of possession. It is settled legal principle that in the case of a usufructuary mortgage where a mortgagee has a right to hold the land mortgaged until the mortgage debt is paid off by appropriation of profits, the right to redeem or to recovery of possession may not accrue until the debt is so satisfied. As pointed out by the Supreme Court in PRITHINATH VS. SURAJ AHIR (AIR 1963 SC 1041), on the payment of the mortgage money by the mortgagor to the mortgagee, the mortgage comes to an end and the right of the mortgagee to remain in possession ceases.
19. It is also equally well settled that when a mortgagee in possession under a usufructuary mortgage holds over after the expiry of the period, for which the mortgage is granted, his possession does not by that fact alone become adverse to the mortgagor, who still has the period prescribed by the article within which the suit for recovery of possession. The mere fact that the mortgagee held on after he ought to have given up possession would not alter the character of the suit as one between the mortgagor and mortgagee and as one falling within the terms of Article 61, clause (a). (BAKHTAWAR BEGUM VS. HUSSAINI KHAUM (26 MLJ 474 (PC) = ILR 36 Allahabad 195))
20. "A mortgagee cannot by a mere assertion of his own title or by unilateral act on his own part convert his possession of moiety of the property as a mortgagee into that of an absolute owner, which he can do so only if he had purchased the entire equity of redemption from the mortgagor. If there has been a sale of the entire property to the mortgagee, thus putting an end to the mortgage, even held to be invalid subsequently, the mortgagee's possession subsequent to the date of the said sale would become adverse, for by the conscious act of the parties, the mortgage would have been put an end to." (SANJIV ROW'S TRANSFER OF PROPERTY ACT, SIXTH EDITION – Page 1198).
21. In the present case, the possession of the defendant can be referable only to his rights as an assignee, the sales in his favour coming to light only when he filed his written statement in the earlier suit. Even according to the defendant, it was only the plaintiff's brother, who sold the property to him, though he would plead that it was on behalf of the plaintiff also. Perhaps, the learned Counsel for the appellant wanted to submit that from the dates of sale in 1970, the suit ought to have been filed within 12 years, viz. 1982 and the suit filed in 1983 was barred by limitation. I cannot agree. It is not possible to hold that the possession of the defendant of the suit properties was referable to the sale deeds in her favour and not the assignment.
22. In PERIYA AIYA AMBALAM VS. SHANMUGHA SUNDARAM (ILR XXVIII Madras 903 (FB)) relied on by Mr. Sreekumaran Nair, it has been held as follows:
"When the owner of the property in possession is dispossessed, the trespasser's possession is clearly adverse to him from its inception, as, to his knowledge, the property is held against his will and he must assert his right within twelve years of his dispossession. But if his mortgagee, who has been placed in possession by him, is followed by another person, there is no presumption in law that such possession was taken without any right. He may be an assignee of the mortgagee or one who purchases the mortgage as a mortgage; or he may be an adverse claimant to the mortgage right; where more than one inference may be drawn, that inference should not be drawn which imputes a wrongful act to a person. The defendant has therefore to show that he took possession of his property as absolute property in contradistinction to mortgage property. Nor is this sufficient; as his possession may be consistent with the mortgagor's title, the mortgagor must obviously have notice that he is holding it as absolute property in denial of any right in him. Otherwise no laches can be imputed to him and the possession cannot be said to be adverse."
The appellant has miserably failed in her attempt to show that she was in possession as her absolute property and not as assignee.
23. Under the Transfer of Property Act read with the Limitation Act, right to redeem and the right of a suit for possession of a mortgaged property are extinguishable on the expiry of 30 years from the date of execution of the mortgage in cases of usufructuary mortgage where no fixed period is provided for redemption. However, where Debt Reliefs Act are made applicable, then they prevent this consequence and if the 30 year period gets over during the coming into force of the Debt Reliefs Act, that is to say, if during the period available for redemption, viz. 30 years in the case of a mortgage, if an agriculturist/debtor becomes entitled to the benefits of the Debt Reliefs Act, then from the date the right accrues, that is to say, when the entire debt is deemed to have been discharged, the right accrues from that day and limitation will begin to run from then on and not from any earlier point of time.
24. For the above proposition we have support from the decision in GNANAMMAL VS. ELAYAPERUMAL NADAR AND OTHERS (1976(2) MLJ 269) where the facts were as follows:
The plaintiff filed the suit for redemption of a usufructuary mortgage created on 29th March, 1899 and claimed the right to redeem it under Madras Act 4 of 1938, as amended by Act 24 of 1950. The suit was dismissed by the trial Court and the lower Appellate Court confirmed it on the ground of limitation.
On second appeal by the plaintiff, it was held as follows: "By reason of the operation of the Madras Act 4 of 1938, the mortgage debt must be deemed to have been wiped out on the day of Amended Act came into force, for, by then the mortgagee or his successor in interest had been in possession of the property for more than the period of thirty years prescribed under the Act. Consequently, the appellant had a statutory right from that date under the provisions of Section 62 of the Transfer of Property Act to seek recovery of possession. As the appellant had filed the suit within a period of thirty years form the date of debt got extinguished by virtue of the Act 4 of 1938 , the appellant must be held to have become entitled to recover possession of the suit property."
The learned Judge further observes that,
"the respondents could not be heard to say that from the date of the wiping out of the mortgage debt by the operation of law, their possession had become adverse to the appellant and therefore the suit filed beyond twelve years was barred by limitation; more so, when there was nothing to show that the respondents had set up hostile title in themselves over the suit property." The learned Judge referred to two earlier decisions of the Allahabad High Court in RAM PRASAD VS. BISHAMBHAR SINGH (AIR 1946 Allahabad 400 ) and PARASRAM VS. BINDESHARI (AIR 1953 Allahabad 33). In the latter decision relied on by the learned Judge, this is what has been expressed by the Bench: "In an application under Section 12, U.P. Agriculturists Relief Act, 1934, it is open to a usufructuary mortgagor to ask for recovery of possession of the mortgaged property without the payment of the mortgage money if the mortgage money has been paid up from the usufruct of the property, and the period of limitation for such an application is sixty years from the date when the mortgage money was so satisfied and the right to recover possession accrued."
25. This decision of the learned single Judge of this Court was affirmed by a Bench in GNANAKAN NADAR VS. GNANAMMAL AND THREE OTHERS (19 80 TLNJ 217). The learned single Judge has also referred to the earlier Privy Council and the Supreme Court decisions in KHIARAJMAL VS. DAIM (ILR 32 Calcutta 296) and LILACHAND VS. MALLAPPA (AIR 1960 SC 85 = 1960(1) SCR 693 = 1960 SCJ 96), where it has been held that,
"where the mortgagee comes into possession of the property pursuant to the usufructuary mortgage, his possession has a lawful origin and a mere assertion of an adverse title on his part cannot affect the subsisting equity of redemption of the mortgagors or operate to shorten the period of limitation prescribed for a suit for redemption."
Again, as pointed out in MULCHAND VS. GANGA (AIR 1951 Nagpur 366) also referred to by the learned single Judge, by the mere fact of satisfaction of the mortgage debt the possession of the usufructuary mortgagee would not become adverse to the mortgagor and as such, the mortgagee cannot be said to have excluded the mortgagor from possession from the date of satisfaction of the mortgage.
26. The learned Counsel persevered for the appellant in her submission that the mortgage was created in 1947, assigned in 1949 and limitation would commence from 1949 if not from 1947 and the suit not having been filed by 1979, was bar5red by limitation. According to the Counsel, right to sue accrued in 1949. For the reasons already stated, this argument cannot pass muster.
27. The learned Counsel made an attempt to interpret the Bench decision in GNANAKKAN NADAR's case as holding that the passing of the Debt Relief Act was alone the material date and not the actual wiping off under one or other of the provisions of the Act. In that case, the usufructuary mortgage was created in 1899. Section 9-A with regard to usufructuary mortgages was introduced by an amendment in 1950 to Act IV of 1938. By operation of Section 9-A, it was held that the debt stood wiped out though 30 years of possession by the mortgagee was over even by 1929. It should also be noted that 60 year period for redemption under Article 148 (Old Act)/Article 61(a) (New Act) had not elapsed by 1950 when the amendment was incorporated providing that if the mortgagee had been in possession for 30 years the debt stood discharged. The cause of action accrued in 1950 in that case. The suit was filed in 1968 within 30 years under the new Limitation Act and 60 years under the old Limitation Act, though it could have been filed even by 1980.
28. In the present case, the usufructuary mortgage was created in 1 947, assigned in 1949, stood wiped out in 1979 and cause of action accrued only then and the mortgagor would have clear 30 years from 1979 under Article 61(a) of the Limitation Act. It is to be further noted that Act IV of 1938 was extended to Kanyakumari District only on 18 -1-1973 and there is therefore no difficulty even otherwise in holding that the mortgage stood discharged after the introduction of the Act in 1973 and the suit filed in 1983 was in time.
29. In BALAMMAL NADACHI AND FOUR OTHERS VS. SELVANAYAGAM @ KUMARACHANDRAPERUMAL & ANOTHER (2002(2) CTC 717 decided by GOVINDARAJAN, J. the mortgage was executed on 29-10-1912, the suit was filed in 1981 relying on two assignment deeds dated 26-4-1943 and 1-7-1946 where the defendants had acknowledged the mortgage of 1912. The learned Judge held that thirty year period had to be counted from 1-7-1946 and before expiry of 30 years Act IV of 1938 was extended to Kanyakumari District with effect from 18-1-1973 and therefore another 30 year period had to be added and the suit filed in 1981 for redemption of suit property was held to be not barred by limitation.
30. For all the reasons stated above, the submissions made on behalf of the appellant cannot be accepted. Consequently, the substantial question of law and the additional substantial question of law are answered against the appellant. The second appeal fails and the same is dismissed. However, there will be no order as to costs. 13-9-2002 Index: Yes
Internet: Yes
1. The Subordinate Judge,
Padmanabhapuram (With records).
2. The Principal District Munsif,
3. The Record Keeper,
V.R. Section,
High Court, Madras.
S.A.No.1940 of 1989
Double Click on any word for its dictionary meaning or to get reference material on it.


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Episode 50: Accidentally Sexist
Posted by The Guys on Aug 29, 2013 | Comments Off on Episode 50: Accidentally Sexist
We are 50 weeks old this week! Woo hoo! This week's show we discuss Elder Scrolls Online, console colors, character gender in games, and much more!
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Boozy popsicles are all the rage now. But for real frozen cocktails, use dry ice ice to make these Red, White and Blue Boozy Popsicles.
Who else out there is sweating it out this glorious summer? I don't know about you, but I've been hustling my kids about, keeping them busy and keeping them cool. It could be a dip in the pool, a trip to the beach or keeping some homemade popsicles in the freezer.
I know I'm not the only one seeing the boozy popsicles circulating the web and Pinterest. And knowing my husband, I decided to do a little research on the matter.
If you don't know, alcohol has a lower freezing point than fruit juice. In lay-man's terms, you can freeze booze in a regular freezer. It just doesn't get cold enough. According to foodie popsicle experts out there, you need to keep the alcohol content in a popsicle at 20% or less for the popsicle to freeze.
So, I made a sample test of boozy popsicles using this formula. My husband complained that he couldn't taste the alcohol. My other guests said the same thing.
"More rum! More vodka! More tequila!"
Now it's not that I have a family full of drunkards or lushes. Even I, a light-weight to drinking, a certified "cheap date" could barely taste the alcohol using the 20% rule.
So, back to the internet I went.
That's when I found this article that talks about using liquid nitrogen to freeze REAL boozy popsicles. I sent it to my husband,who decided to descend back to middle school because the article called these cocktail popsicles, "cocksicles."
"Do you have a dewar?" I asked the man who has every tool and gadget possible in our jam-packed garage.
He did not. But it got his brain thinking and he came home with a cooler filled with dry ice.
He mixed himself some margaritas. Poured them into dixie cups with popsicle sticks. A couple hours later, we had our first successful boozy popsicles.
Dry ice is definitely a safer alternative to using liquid nitrogen, plus you can find it at your local grocery store. But a few words of caution:
- Never touch dry ice with your fingers – you can burn them severely.
- Keep your dry ice in an insulated cooler.
- How long your dry ice lasts depends on how much you have, so if you are making boozy popsicles for a party, buy the dry ice a few hours before your party.
- Let the dry-ice boozy popsicles sit in the freezer or out in the open air to warm a little so your guests do not burn their tongues on the popsicles. Picture Ralph and the tongue stuck to the flag pole moment in "A Christmas Story."
Let your creativity flow and have fun with it. To celebrate America's Independence Day, I made these Red, White & Blue Boozy Popsicles. The were made in stages. First layer was blue, using a raspberry cocktail mixer with vodka.
After that froze (about an hour), I added the white layer lemon/lime soda with vodka. The red layer was cranberry juice & vodka.
You can keep your boozy popsicles in the freezer. They won't turn to water, but will have more of an icy, crumbly, slushy kind of texture.
Note: To make these kid-friendly, use different kinds of Kool-Aid or Gatorade for the same effect!
Need more red, white and blue inspiration?
Perhaps a slice of this Red, White and Blue Cake with Berries, Coconut and Rum will hit the spot? Or these easy-to-whip-up Red, White and Blue Ice Cream Cupcakes?
Red, White & Blue Boozy Popsicles
Perfect for your patriotic celebration or just to stay cool, these frozen cocktails stay frozen using dry ice. Recipe by Laura Bashar of Family Spice
- 8 lb dry ice, broken into pieces
- 1/2 cup Rose's Blue Raspberry Cocktail Mix
- 1 1/2 cup vodka
- 1/2 cup lemon-lime soda
- 1/2 cup cranberry juice
- In a well insulated cooler cover and store:
- 8 lb dry ice , broken into pieces
- 1/2 cup Rose's Blue Raspberry Cocktail Mix
- 1/2 cup vodka
- 1/2 cup lemon-lime soda
- 1/2 cup vodka
- 1/2 cup cranberry juice
- 1/2 cup vodka
Serving Suggestions:
Never touch dry ice with your fingers - you can burn them severely.
Keep your dry ice in an insulated cooler.
How long your dry ice lasts depends on how much you have, so if you are making boozy popsicles for a party, buy the dry ice a few hours before your party.
Let the dry-ice boozy popsicles sit in the freezer or out in the open air to warm a little so your guests do not burn their tongues on the popsicles. Picture Ralph and the tongue stuck to the flag pole moment in "A Christmas Story."
Cooking Tips: The measurements used are approximate and do not need to be exact. You adjust the juice-alcohol ratio to your liking. Some layers may have gotten a splash or two more than the amount listed!!
This technique can be used with any alcoholic cocktail you want to serve frozen as a boozy popsicle.
Prep Time:
Yield: 12 servings


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Melody, harmony & beyond – Antara – A musical confluence is a multi hued rainbow that emerges when the great waves of occidental notes strike against the solid rocks of Carnatic music. From the scintillating melodies of Saint Tyagaraja to the swaying padams of Irayimman Thampi, this novel collection comprises of a spectrum of traditional Krithis sung in their purest and undiluted form with a most sophisticated musical orchestration. The cadences of these songs have been woven in such a manner that they are apt for traditional repertoire of classical dances. Through this, the makers of this album have tried to bring out the quintessence of musical ethos in an extraordinary treatment of notes and rhythms so as to present a novel and dreamlike experience to all music lovers.
ANTARA recorded,
programmed and mixed by A.S.Sreejith,
Singer Abhiram Unni,
Violin V.S.Gokul Alangode,
Mridangam Sajinlal Edappal,
Flute A.K.Raghunath,
Edakka Anoop Vellattanjoor,
Veena Biju Annanmanada,


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However cliched it may be, there is something heartwarming about the sheer enthusiasm and exuberance and sense of renewal that infects all of us at New Year.
Like every single one of you, I imagine, my WhatsApps are full of good wishes and videos of champagne bottles popping open, and Instagram this morning has nothing but amazing images of fireworks ushering in 2018 from all corners of the globe.
Yes, you're right, it is possibly a tad sappy, but hey! it's the first day of a brand new year and everyone is entitled to hope for better things, for change, […]
Click to continue reading Happy New Year. From the taxman


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§ 37. The Regal Office.
To Him, who announced to the world God's gracious purpose of redemption, and who Himself accomplishes the redemption, the dominion over the world is committed; and, in exercising this dominion, He performs a regal function. This regal dignity belongs to Christ, as God, from eternity; but from the moment of His incarnation His humanity also participated in it. [1] Yet, as long as He tarried here upon earth, He did not exercise this regal dominion in its full extent; but rather, as long as He was in the state of humiliation, refrained, for the most part, from its use and exercise, and not until the time of His exaltation did He enter upon the complete exercise of this, His regal dominion. [2] Inasmuch as Christ is thus King and Lord of the world, His dominion extends over everything that is in the world and belongs to it; and there appertains to Him not only the preservation and government of the world in general, but also the preservation and government of the Church in particular. At the same time, this His dominion extends not only over the present, but equally also over the future world. This kingdom of Christ is, in itself, only one, and embraces the whole world, the present and the future, with all that it contains. Yet this one kingdom can also be distinguished as a threefold one, in the same sense in which we distinguish at present the world and the Church, and in which we distinguish the citizens of this and of the future life, of heaven and of earth. Accordingly, the world and the Church, in this life, are regarded as each a special kingdom, over which Christ rules; and those who are in the life to come constitute the third kingdom. This threefold kingdom is designated as the kingdom of power, of grace, and of glory. The first is called the Kingdom of Power, because it is the kingdom in which Christ exercises His divine power by governing and upholding the world; the second is called the Kingdom of Grace, because in this Christ operates through His saving grace; the third is called the Kingdom of Glory, because He therein unfolds, in all its perfection, His divine glory before the eyes of all who are there assembled. [3]371
The regal office is accordingly defined as, "The theanthropic function of Christ, whereby He divinely controls and governs, according to both natures the divine and the human (and the latter, as exalted to the Right Hand of Majesty), all creatures whatever, in the kingdom of power, grace, and glory, by infinite majesty and power: as to the divinity, by virtue of eternal generation; as to the assumed humanity, by virtue of the personal union belonging to Him." (QUEN., III, 264.) [4]
To the Kingdom of Power ("in which Christ powerfully rules over this universe, and upholds it and providentially governs it") belong all creatures in the world, visible and invisible; [5] Christ's dominion extends over them all, and all must be subject unto Him. By Him everything is upheld and governed. [6]
To the Kingdom of Grace ("in which Christ collects the Church Militant upon earth, governs it, furnishes it with spiritual gifts, preserves and defends it, to the praise of the divine name, to the destruction of Satan's kingdom, and the salvation of believers," Jer. 23:5; 33:15; Zech. 9:9; HOLL., 763) belong those who believe in Christ, the members of His Church. To enlarge this Church, and to bestow upon its members all the blessings of the Gospel, is the regal function which Christ exercises in this kingdom, [7] and the Word and Sacraments are the means which He uses for that purpose. [8] This kingdom will, it is true, come to an end in this world, but only by passing over into the kingdom of glory. [9]
To the Kingdom of Glory, finally ("in which Christ most gloriously rules the Church Triumphant in heaven, and fills it with eternal felicity, to the praise of the divine name and the eternal refreshment of the saved," Matt. 25:34; John 17:24; HOLL., 763), belong all the inhabitants of heaven, the good angels and redeemed men. They behold the Lord in His glory, as He shows Himself to the dead, when He awakens them to life. [10] This glory of the Lord begins with the time of His ascension to heaven, but will not be perfectly unfolded until, after the final judgment, believers also will enter into the kingdom of His glory, to share with Him its possession. Matt. 25:34. [11]
[1] QUEN. (III, 260): "Just as Christ, in His prophetic and 372sacerdotal offices, acts and works according to both natures, so also, according to both natures, in this regal office He acts and performs His part; for He rules over all creatures, not only as God, according to His divinity, but also as man, according to His exalted humanity." The Holy Scriptures speak of a regal dignity in Ps. 2:6; 20:9; 45:1, 3, 5; 47:7; Heb. 2:7, 8; Ps. 8:6; 97; 5; 2 Sam. 23:3; 1 Tim. 6:15; Rev. 17:14; 19:16.
QUEN. further remarks (III, 261): "One in number is that regal power which Christ, according to His divine nature, has, and according to His human nature, possesses. Only the mode of having it varies; for what, according to His divinity, He has by eternal generation from eternity, that, according to His humanity, through and because of the personal union, He has received in time, and fully exercises now in the state of exaltation." His power to rule, even according to His human nature, is evident from Ps. 8:6; Jer. 23:5; John 17:5.
[2] HOLL. (764): "Christ immediately, in His very conception, was anointed to a regal dignity, and, during His visible intercourse upon the earth, possessed the power to rule, and sometimes exercised it according to His pleasure. But, in the state of humiliation, He voluntarily refrained from the most full and uninterrupted employment of His rule." Christ, therefore, "during that time in which He visibly dwelt on this earth, was a true King. Luke 2:11; 19:35; Mark 14:61. There is an antithesis of the Socinians, who say that Christ, before His resurrection, was not actually a King; although they do not deny that before His death, He was described as a King." (HOLL., 764.) QUEN. (III, 264): "A distinction must, therefore, be made here between the appointment to this regal office and the refraining from the full administration and use of the same. Christ, as man, was King and Lord even in the womb (Luke 1:43), in the manger (Luke 2:11), in bonds (John 18:37), on the cross (Luke 23:42); and yet did not actually exercise that dominion." That Christ also possessed regal power in the state of humiliation, the Dogmaticians regard as proved by His performing miracles.
[3] HUTT. and HFRFFR. still account, as belonging to the regal office, only His dominion over believers; and GRH., who was contemporaneous with them, was the first to include under the regal office all the relations in which Christ is Lord and King, and in this they were imitated by all the later Dogmaticians. Of course, no doctrinal difference was hereby intended. The faith of the Church always was, that Christ was Lord and King of the world. Thus we have it stated, e.g., by CHMN. (De duab. naturis, 205): 373"Scripture clearly affirms that to Christ, even according to His humanity, as Lord, all things have been made subject, not only in the Church, but all things in general; . . . and distinct and express mention is made of the beasts of the field, the fowls of the air, the fish of the sea, and all the works of God's hands, whether they be in heaven, or on earth, or under the earth, even of the enemies of Christ, and, therefore, the devil and death itself, as being in this subjection." The difference is only this, that GRH. was the first to introduce the method of arranging under one head all that is to be said concerning the dominion of Christ.
As to the division itself. GRH. (III, 578): "The kingdom of Christ is considered either in this or in the future life. In this life, it is called the kingdom of power or grace; . . . in the life to come, it is called the kingdom of glory." BR. (498): "The regal office of Christ is threefold, according to the diverse nature of those whom He regards as His subjects, and governs diversely. For although, if you regard the words themselves, the kingdom of grace, as well as that of glory, may seem to be comprised under the kingdom of power, as both truly depend upon divine power imparted to the human nature of Christ, yet the usus loquendi requires it to be named the kingdom of grace, with respect to the spiritual blessings which are conferred in this world, and the kingdom of glory, with respect to the glory of the future world; while the kingdom of power signifies a universal government." QUEN. (III, 264): "Some say that Christ reigns in the world by power, in the Church by grace, in heaven by glory, and in hell by justice." In regard to the last, HOLL. observes (763): "You say, that 'also a fourth kingdom of Christ is mentioned, viz., the kingdom of justice over the wicked angels and condemned men. Reply: We refer the kingdom of justice to the kingdom of power." On the other hand, BR. (501): "Some, referring both (the kingdom of glory and the kingdom of justice) to the same kingdom of glory, say that the glorifying of the elect belongs by itself to the former; but the condemnation of the wicked . . . they refer to the latter in the manner in which under other circumstances opposites are wont to be referred to the same faculty."
The threefold division is, accordingly, not to be understood as if there were three separate kingdoms over which Christ rules, but the reason of the division lies (1) partly in the different divine influences which Christ exerts. The same persons who are in the kingdom of grace are also in the kingdom of power; but in the one kingdom the divine saving grace, and in the other the divine power, is exercised; (2) partly in the difference of the places in which they 374are found, over which Christ rules, viz., in the one case upon earth, and in the other in heaven.
QUEN. (III, 264): "The kingdom of grace includes, or rather presupposes, the kingdom of power; for the kingdom of power is required for the kingdom of grace, or the Church, which in this world is to be established, ruled, etc., through the ministry of the Spirit by means of the Word and Sacraments."
[4] GRH. (III, 578): "The regal office is that according to which Christ as the God-man governs all things in heaven and earth, and especially protects His Church against enemies." On the other hand, HFRFFR. (353) (see note 3): "The regal office is that according to which, to the end of the world, through the ministry of the Word, He collects His citizens, and, having furnished them with eminent gifts, vigorously defends them against enemies (in whose midst He rules), and at length crowns them with eternal glory and honor."
[5] QUEN. (III, 265): "The object or matter with which this government is occupied comprises all the works of God in general, or all creatures, visible, invisible, corporeal, incorporeal, animate, inanimate, rational, irrational. Ps. 8:6, 7, 8; 1 Cor. 15:27, 28; Heb. 2:7, 8; Eph. 1:21, 22; 1 Pet. 3:22."
[6] GRH. (III, 578): "The kingdom of power is the general dominion over all things, or the governing of heaven and earth, Ps. 8:6; Dan. 7:14; Matt. 28:18; Eph. 1:21; the subjugation of all creatures, 1 Cor. 15:27; Eph. 1:20; Heb. 2:8; dominion in the midst of His enemies, whom He suppresses, restrains, and punishes, Ps. 2:9; 110:2; 1 Cor. 15:25."
[7] HOLL. (763): "The subjects, in this kingdom of grace, are all believing men, who constitute the Church Militant. The regal acts are the collecting, governing, adorning, and preservation of the Church, His defense of it against the enemies of grace, and His ruling in their midst. John 3:5; 17:17; Eph. 5:26; Tit. 3:5; Matt. 28:20." When QUEN. (III, 268), on the other hand, says: "The object of the kingdom of grace, according to the antecedent will, comprises all men universally, but the godly and believing especially," he means to say only that participation in the blessings of the Church is intended for, and sincerely offered to all men, and, therefore, does not contradict the statement of HOLL.
[8] QUEN. (III, 267): "The Word and Sacraments are the instrumental cause, for it pleased the King in Zion, Ps. 2:6, to act here ordinarily in no other way than by the Word and Sacraments, and by these means to collect, increase, and preserve on this earth a Church for Himself. Matt. 4:23; 9:35; 24:14."375
[9] QUEN. (III, 270): "The end of the world will indeed terminate the mode of the kingdom of grace, but not the essence of the kingdom. That which is said in 1 Cor. 15:24, concerning the giving up of this kingdom, is to be understood, not as applying to the government itself, but only to the mode of governing, and the form and quality of the government; because Christ will govern no longer through means, namely, through the word and Sacraments, through the cross and among enemies, but, all enemies being put down, the last enemy, viz., death, being destroyed, and the wicked being cast into hell, He will deliver the kingdom to God the Father, i.e., He will hand over the captive enemies and establish the elect, among whom He hold His spiritual kingdom. Therefore there will be a triumphal handing over of subjugated enemies, and a presentation of liberated believer. By this act of handing over, Christ will not lay aside the administration of His spiritual and heavenly kingdom, but will then only enter upon another mode of ruling." QUEN. then quotes approvingly Dorschaeus: "This handling over will be not actus depositionis, sed propositionis. Christ will not at the consummation, lay down the kingdom, which, up to the consummation, He has governed in grace and in glory; but He will present it to God the Father for His inspection and glory. Just as a general, after having destroyed all his enemies, presents to the king, who through him has waged the war, the victorious and triumphant army, the saved citizens, and the free people, and tenders them to him, that he may judge and approve his deeds, and nevertheless does not lay down the power which he had over the army; so, much more, when the world is ended, and all enemies have been suppressed, shall Christ, as the Son, place His immaculate (Eph. 5:27) ecclesiastical army in the presence of God the Father, before His tribunal, Rom. 14:10, and shall say: 'These are they who are not defiled, who have followed me, the Lamb, whithersoever I have gone, who are the first fruits to Thee, O God, the Father, and to me the Lamb, Rev. 14:4.'"
[10] HOLL. (763): "The subjects in this kingdom of glory are both good angels and glorified men (who in faith continue in the kingdom of grace to the end. Matt. 24:13; Rev. 2:10). The regal acts are: the raising to life of the believing dead, their solemn introduction into life eternal, Matt. 25:34; Luke 22:29, 30, and the most happy and glorious rule over them."
[11] QUEN. (III, 273): "Christ, the king of glory, indeed, even as a man, immediately from His first conception, was the possessor of all glory, but did not actually rule gloriously until after His exaltation, when His sufferings were finished. This very kingdom 376of glory will truly receive its final completion in the general resurrection of the dead, the assembling of all of the elect, and their translation to the possession of the heavenly inheritance, and thence will endure to eternity."
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What are the Best Debt Consolidation Companies in Denair CA
Who has the best Denair debt consolidation services?
Denair consolidation services offer a way of taking multiple debts and taking them all and wrapping them together into one payment. So if you have 5 different Denair loans, each with a different interest rate and length, a Denair debt consolidation loan will pay these off and then you will be left with one Denair loan with a total on the loan of all the paid off loans. The best part is that these types of Denair consolidation loans typically have lower interest rates than the ones you are getting rid of.
What is the best place in California to find Denair credit consolidation lenders?
Search online for the best debt consolidation lenders in Denair CA. The reason the best place to find Denair debt consolidation lenders in California is because you will be able to find the right Denair lender for you. Your local Denair banks may not specialize in the right Denair consolidation loans for you or have California lending standards that are too stringent. By searching for the best California debt consolidation loans online, you can assure yourself of getting the right Denair loan.
More On Debt Consolidation Loans in Denair CA
As I said above, prior to the credit crunch we had basically "easy money" whereby the Denair banks were encouraged to lend to pretty much anyone in California with a pulse. As the economy tanked and their Denair debts mounted, a large portion of these people who got easy credit are now looking for Denair credit consolidation programs. These Denair loans can be obtained but they are just like any other Denair loan. Your California credit rating, your ability to repay the Denair loan, an availability of collateral to secure the loan and the current Denair bank policies on California lending will determine if you get a Denair consolidation loan or not.
Where Is The Best Denair Loan Consolidation Service?
As I discussed above, the typical Denair loan consolidation service usually has a lower interest rate than the standard California loan that is putting you in the poor house. Be aware that just because you are in trouble with your Denair monthly payments, does not mean that you will automatically get Denair loan consolidation.
Where Can I find The Best Denair Debt Consolidation Help?
I spoke of collateral before and this is a big aspect of why Denair debt consolidation lenders may give you Denair loan consolidation. Unsecured Denair loans are the riskiest loans to give by a California lender. This is because if the Denair loan is defaulted on, the bank cannot get the money back. By requiring collateral to provide security on a loan (as some Denair banks do for Denair debt consolidation loans) the bank reduces their risk for the loan. A secured Denair loan allows the lender to offer the loan to you and then to offer the Denair loan at a reduced interest rate. Be careful to make sure you pay off the Denair credit card consolidation loan on time. If you were required to put up collateral and you default, the Denair bank will take that collateral as a way to recoup their loss.
Where Can I find The Best California Debt Consolidation Help?
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53's Paper app for the iPhone
John Paul Titlow, Fast Company:
Ian Curry, a visual designer at FiftyThree, blurted out: "Why don't we visually format the text?" After some back and forth, the team settled on what they now call swipe-to-style, a way of formatting text using gestures instead of interface buttons. Over the next 48 hours, a developer coded up a prototype called Text Trial, an internal app that would allow them to test out different methods of formatting text with touch gestures.
I love this interaction model. The article is worth a proper read, too. They could've released the iPhone version three years ago, but didn't because they want to get it right. The read is just a glimpse how much thought and craft went into making the port.
/via Benoît


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Are you looking for an option to buy laboratory instruments for your research and analytical purpose? If so, you are in the right place. We at www.lelab.com.my provide all types of advanced equipments and instruments used for laboratory purpose. You can find almost all types of lab equipment models with us that you can use to identify, analyze, measure as well as monitor different samples and materials. We have gained a lot of popularity in the market for the high quality products we provide for the customers. It does not matter what type or equipment or lab material you are looking for, if you get in touch with our experts, they will guide you with the best deals. Another aspect of suggesting you to buy the lab equipments provided by our company is due to the fact that our equipments adhere to highest safety standards.
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For Sale
We generally have horses for sale from broodmares, to riding horses, to babies. We would love for you to come out and let us help you acquire the Akhal-Teke of your dreams.
Offline Marketing
As young as our herd is at the moment, we are not able to compete as much as we would enjoy, but certainly we will be going to any competition and/or show we're ready for. Keep checking back to see what events we'll be attending in the near future!
Social Media
Check us out on Facebook! All throughout the summer we'll be updating with pictures and more! We also have our trainers YouTube Channel, which will be filled with videos of each horse for sale coming soon!
Understand Our Goals
We are a small company, dedicated to the growth and re-development of the Akhal-Teke. This ancient, Heavenly Horse, has not only proved it can be a top competitor, but also a companion. Our horses are ready for that one person they can simulate with and connect to at a spiritual level.
We don't want to be another specific breed site that preaches about the uniqueness and the difference. We want to prove that our horses are smart, have confirmation correctness, are affectionate and willing to try new obstacles in life.
- Tiffany Deitchler
- (218) 252-9243
- Rodney Hunt
- (218) 573-2434
- Deana Deitchler
- (218) 252-3302


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Purchase this article with an account.
Takahiro Kawabe, Kazushi Maruya, Shin'ya Nishida; The role of dynamic visual information in the estimation of liquid viscosity. Journal of Vision 2012;12(9):870. doi: https://doi.org/10.1167/12.9.870.
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© ARVO (1962-2015); The Authors (2016-present)
Humans can judge liquid viscosity using only visual information. For example, honey is 'thick' (i.e. high viscosity), while water is 'thin' (low viscosity). Even though this sort of liquid viscosity estimation is mundane, vision science has not addressed what image processing underlies the estimation. The purpose of this study was to examine visual factors enabling us to estimate liquid viscosity, focusing on dynamic visual information. We employed the Blender physics engine to simulate kinetic viscosity of liquids, and created 50 movies (ten scenes each with five kinematic viscosities). The observers were asked to watch each of the movies, and subjectively rate liquid viscosity We first confirmed that the rated viscosity increased nearly in proportion to the simulated kinematic viscosity. To examine how simulated viscosity was related to the speed of liquid flow, we computed optical flow of liquid flow. The histogram of the speed of motion signals indicated that a liquid flow with a lower kinetic viscosity tends to have a higher overall speed. To examine the effect of overall speed of liquid flow on viscosity rating, we manipulated frame duration of each movie, and found that the rated viscosity increased with the frame duration. To investigate the importance of the spatial pattern of motion speed, we divided a movie into an array of cells (each of the cells was windowed by a tapered cosine circular function), and randomized image orientation within each cell (direction scramble), or shuffled the positions of cells (position scramble). Viscosity rating was generally unchanged when the stimuli were scrambled in these ways. However, when the cell size was small, scrambling position decreased the correlation between observers' viscosity rating and simulated viscosity. The results indicate that in estimating liquid viscosity the visual system makes use of motion speed distribution.
Meeting abstract presented at VSS 2012
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The first floor is the "hub" for most of the Mills Park Hotel's daily activity. Guests check in and check-out at the Front Desk, which is staffed 24 hours a day. This level also houses our general store, restaurant and banquet hall, as well as a few guest rooms. Ellie's Restaurant & Bakery and the Little Miami Mercantile are open to the public. For current store and restaurant hours, call 937-319-0400.
Mills Park Hotel's fitness and conference rooms and a casual business lounge can be found on the second floor. The open layout of the second level overlooks the main lobby toward the rear of the hotel. Several second-floor guest rooms also include balconies overseeing Xenia Avenue, the main thoroughfare through Yellow Springs.
The third floor boasts some of the Hotel's most spacious guest rooms with some great perspective views of the surrounding village of Yellow Springs. It also includes a colorful and casual sitting area, which is well-lit by large plantation-style windows.
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text: T-ara HyoMin at YCH and pushBUTTON's event It's a hectic Thursday for T-ara's HyoMin! She was out to attend two events at the 2016 Hera Seoul Fashion Week today, and below is where you can see her gorgeous pictures from YCH and pushBUTTON's event. Posted by nearnine at 8:21 PM Labels: Hyomin, Pictures, T-Ara


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After defeating Arsenal last month Spurs had established a commanding seven-point lead over their north London rivals and moved third in the table.
However, by the time they play their next Premier League game – against reigning champions Manchester City on April 21 – they could be facing a seven-point deficit to Arsène Wenger's team.
In their last three home games, Tottenham have lost to Fulham and drawn 2-2 against both Basle and Everton, with forward Dempsey conscious that the supporters are becoming nervous. "It's been tense," he said. "I've felt like that's kind of what the atmosphere's been. That's the way it's been the last few games."
Asked if that tension was affecting the players, Dempsey said: "I don't know. It's something that's been there. It's been noticeable in the last three home games.
"You've got to keep going. You've got to do everything you can to help the team win. You can only try your best. It's going to be a fight all the way until the end."
The 30-year-old American pointed to some key injuries and the fixture schedule as possible reasons for Tottenham's dip and admitted that Arsenal's form has added a "good stress" to the season.
He continued: "Who's to say the reason why? Maybe a few injuries, maybe a lot of games. It makes it more interesting for people to watch. It's a little bit more stressful but it's a good stress. At least we're pushing to try to get that [Champions League] spot. Hopefully we have enough character to get the job done.
"I thought the boys showed a lot of character to fight back and get a point against Everton. It's an important point. You would have like to have got three but at least we fought back. We have the quality. It's about being confident. It will be difficult all the way until the end of the season."
Chelsea's involvement in the FA Cup semi final on Sunday means that Tottenham now have a two-week break from the Premier League. Although Arsenal have three matches in that period, Spurs could still benefit from the extra time that Gareth Bale, Aaron Lennon and Jermain Defoe will have to recover from respective ankle, knee and groin injuries.
Nevertheless Lewis Holtby believes that Sunday's match against Everton was a vital missed opportunity to win and expects the fixtures at home to City and then away to Chelsea to ultimately prove decisive.
Asked if Tottenham, who just missed out on a Champions League's spot the last two seasons, had needed to beat Everton, the German international said: "I think so, yes. But the positive is that we didn't lose to a rival. It was a good performance in the second half but, if we want to play in the Champions League, we want to win those games.
"We've still got decisive games against City at home and against Chelsea away. Even the games against Southampton and Sunderland, these games we have to win. After 38 games, we have to stay in the top four."
Holtby, 22, is confident that the Tottenham players will ultimately deliver but also alluded to the tension inside White Hart Lane, particularly when they were chasing an equaliser against Everton on Sunday.
"I have big faith in us because we have a quality side," he said. "Of course if you look at the watch and it's still 2-1, you want to get that goal, you're a little bit nervous then but I think we kept our calm. That's why we got the goal. Our patience was big.
"The past is not in our favour but I think this team has so many qualities to get in the Champions League. If you view the season, all the effort we have put in, I think we deserve it."


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We're leaving tonight for WI to go to Cory's state tournament for baseball. I'm so excited to watch him pitch & cheer the boys on. Look at these great shirts Cory made us last night! Lets go Braves!!
Aren't they the cutest?
Thanks Cory 🙂
Sunny with a Chance of Sprinkles
a sunny little lifestyle blog


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Sobriety Success
Metabolism of nitrogen functionalities (e.g., amines, amides) is important because such functional groups are found in many natural products (e.g., morphine, cocaine, nicotine) and in numerous important drugs (e.g., phenothiazines, antihistamines, tricyclic antidepressants, j-adrenergic agents, sympathomimetic phenylethylamines, benzodiazepines).159 The following discussion divides nitrogen-containing compounds into three basic classes:
1. Aliphatic (primary, secondary, and tertiary) and alicyclic (secondary and tertiary) amines
2. Aromatic and heterocyclic nitrogen compounds
The susceptibility of each class of these nitrogen compounds to either a-carbon hydroxylation or N-oxidation and the metabolic products that are formed are discussed.
The hepatic enzymes responsible for carrying out a-carbon hydroxylation reactions are the CYP mixed-function oxidases. The N-hydroxylation or N-oxidation reactions, however, appear to be catalyzed not only by CYP but also by a second class of hepatic mixed-function oxidases called amine oxidases (sometimes called N-oxidases).160 These enzymes are NADPH-dependent flavoproteins and do not contain CYP.161,162 They require NADPH and molecular oxygen to carry out N-oxidation.
Tertiary Aliphatic and Alicyclic Amines. The oxidative removal of alkyl groups (particularly methyl groups) from tertiary aliphatic and alicyclic amines is carried out by hepatic CYP mixed-function oxidase enzymes. This reaction is commonly referred to as oxidative N-dealkylation.163 The initial step involves a-carbon hydroxylation to form a carbinolamine intermediate, which is unstable and undergoes spontaneous heterolytic cleavage of the C-N bond to give a secondary amine and a carbonyl moiety (aldehyde or ketone).164,165 In general, small alkyl groups, such as methyl, ethyl, and isopropyl, are removed rapidly.163 N-dealkylation of the t-butyl group is not possible by the carbinolamine pathway because a-carbon hydroxylation cannot occur. The first alkyl group from a tertiary amine is removed more rapidly than the second alkyl group. In some instances, bisdealkylation of the tertiary aliphatic amine to the corresponding primary aliphatic amine occurs very slowly.163 For example, the tertiary amine imipramine
(Tofranil) is monodemethylated to desmethylimipramine (desipramine).166,167 This major plasma metabolite is pharmacologically active in humans and contributes substantially to the antidepressant activity of the parent drug.168 Very little of the bisdemethylated metabolite of imipramine is detected. In contrast, the local anesthetic and antiarrhyth-mic agent lidocaine is metabolized extensively by N-deethy-lation to both monoethylglycylxylidine and glycyl-2,6-xyli-dine in humans.169,170
Numerous other tertiary aliphatic amine drugs are metabolized principally by oxidative N-dealkylation. Some of these include the antiarrhythmic disopyramide (Norpace),171,172 the antiestrogenic agent tamoxifen (Nolvadex),173 diphenhydramine (Benadryl), 174,175chlorpromazine (Thorazine),176,177 and (+)-a-propoxyphene (Darvon).178 When the tertiary amine contains several different substituents capable of undergoing dealkylation, the smaller alkyl group is removed preferentially and more rapidly. For example, in benzpheta-mine (Didrex), the methyl group is removed much more rapidly than the benzyl moiety.179
An interesting cyclization reaction occurs with methadone on N-demethylation. The demethylated metabolite normethadone undergoes spontaneous cyclization to form the enamine metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine (EDDP).180 Subsequent N-demethylation of EDDP and isomerization of the double bond leads to 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP).
Many times, bisdealkylation of a tertiary amine leads to the corresponding primary aliphatic amine metabolite, which is susceptible to further oxidation. For example, the bisdesmethyl metabolite of the H1-histamine antagonist brompheniramine (Dimetane) undergoes oxidative deami-nation and further oxidation to the corresponding propionic acid metabolite.181 Oxidative deamination is discussed in greater detail when we examine the metabolic reactions of secondary and primary amines.
Like their aliphatic counterparts, alicyclic tertiary amines are susceptible to oxidative N-dealkylation reactions. For example, the analgesic meperidine (Demerol) is metabolized principally by this pathway to yield normeperidine as a major plasma metabolite in humans.182 Morphine, N-eth-ylnormorphine, and dextromethorphan also undergo some N-dealkylation.183
Direct N-dealkylation of t-butyl groups, as discussed below, is not possible by the a-carbon hydroxylation pathway. In vitro studies indicate, however, that N-t-butyl-norchlorocyclizine is, indeed, metabolized to significant amounts of norchlorocyclizine, whereby the t-butyl group is lost.184 Careful studies showed that the t-butyl group is removed by initial hydroxylation of one of the methyl groups of the t-butyl moiety to the carbinol or alcohol product.185 Further oxidation generates the corresponding carboxylic acid that, on decarboxylation, forms the N-isopropyl derivative. The N-isopropyl intermediate is dealkylated by the normal a-carbon hydroxylation (i.e., carbinolamine) pathway to give norchlorocyclizine and acetone. Whether this is a general method for the loss of t-butyl groups from amines is still unclear. Indirect N-dealkylation of t-butyl groups is not observed significantly. The N-t-butyl group present in many jS-adrenergic antagonists, such as terbutaline and
salbutamol, remains intact and does not appear to undergo any significant metabolism.186
Alicyclic tertiary amines often generate lactam metabolites by a-carbon hydroxylation reactions. For example, the tobacco alkaloid nicotine is hydroxylated initially at the ring carbon atom a to the nitrogen to yield a carbinolamine intermediate. Furthermore, enzymatic oxidation of this cyclic carbinolamine generates the lactam metabolite cotinine.187,188 Formation of lactam metabolites also has been reported to occur to a minor extent for the antihistamine cyprohep-
tadine (Periactin)189,190 and the antiemetic diphenidol (Vontrol).191
N-oxidation of tertiary amines occurs with several drugs.192 The true extent of N-oxide formation often is complicated by the susceptibility of N-oxides to undergo in vivo reduction back to the parent tertiary amine. Tertiary amines such as H1-histamine antagonists (e.g., orphenadrine, tripel-ennamine), phenothiazines (e.g., chlorpromazine), tricyclic antidepressants (e.g., imipramine), and narcotic analgesics (e.g., morphine, codeine, and meperidine) reportedly form
N-oxide products. In some instances, N-oxides possess pharmacological activity.193 A comparison of imipramine N-oxide with imipramine indicates that the N-oxide itself possesses antidepressant and cardiovascular activity similar to that of the parent drug.194,195
Secondary and Primary Amines. Secondary amines (either parent compounds or metabolites) are susceptible to oxidative N-dealkylation, oxidative deamination, and N-oxidation reactions.163'196 As in tertiary amines, N-dealkylation of secondary amines proceeds by the carbinolamine pathway. Dealkylation of secondary amines gives rise to the corresponding primary amine metabolite. For example, the ^-adrenergic blockers propranolol46'47 and oxprenolol197 undergo N-deisopropylation to the corresponding primary amines. N-dealkylation appears to be a significant biotransformation pathway for the secondary amine drugs methamphetamine198,199 and ketamine,200,201 yielding amphetamine and norketamine, respectively.
The primary amine metabolites formed from oxidative dealkylation are susceptible to oxidative deamination. This process is similar to N-dealkylation, in that it involves an initial a-carbon hydroxylation reaction to form a carbinolamine intermediate, which then undergoes subsequent carbon-nitrogen cleavage to the carbonyl metabolite and ammonia. If a-carbon hydroxylation cannot occur, then oxidative deamination is not possible. For example, deamination does not occur for norketamine because a-carbon hydroxylation cannot take place.200,201 With methamphetamine, oxidative deamination of primary amine metabolite amphetamine produces phenylacetone.198,199
In general, dealkylation of secondary amines is believed to occur before oxidative deamination. Some evidence indicates, however, that this may not always be true. Direct deamination of the secondary amine also has occurred. For example, in addition to undergoing deamination through its desisopropyl primary amine metabolite, propranolol can undergo a direct oxidative deamination reaction (also by a-carbon hydroxylation) to yield the aldehyde metabolite and isopropylamine (Fig. 3.9).202 How much direct oxidative deamination contributes to the metabolism of secondary amines remains unclear.
Some secondary alicyclic amines, like their tertiary amine analogs, are metabolized to their corresponding lactam derivatives. For example, the anorectic agent phen-metrazine (Preludin) is metabolized principally to the lactam product 3-oxophenmetrazine.203 In humans, this lactam metabolite is a major urinary product. Methylphenidate (Ritalin) also reportedly yields a lactam metabolite, 6-oxori-
talinic acid, by oxidation of its hydrolyzed metabolite, rital-inic acid, in humans.204
Metabolic N-oxidation of secondary aliphatic and alicyclic amines leads to several N-oxygenated products.196 N-hydroxylation of secondary amines generates the corresponding N-hydroxylamine metabolites. Often, these hydroxylamine products are susceptible to further oxidation (either spontaneous or enzymatic) to the corresponding ni-trone derivatives. N-benzylamphetamine undergoes metabolism to both the corresponding N-hydroxylamine and the nitrone metabolites.205 In humans, the nitrone metabolite of phenmetrazine (Preludin), found in the urine, is believed to be formed by further oxidation of the N-hydroxylamine intermediate N-hydroxyphenmetrazine.203 Importantly, much less N-oxidation occurs for secondary amines than oxidative dealkylation and deamination.
Primary aliphatic amines (whether parent drugs or metabolites) are biotransformed by oxidative deamination (through the carbinolamine pathway) or by N-oxidation. In general, oxidative deamination of most exogenous primary amines is
carried out by the mixed-function oxidases discussed previously. Endogenous primary amines (e.g., dopamine, norepinephrine, tryptamine, and serotonin) and xenobiotics based on the structures of these endogenous neurotransmitters are metabolized, however, via oxidative deamination by a specialized family of enzymes called monoamine oxidases (MAOs).206
MAO is a flavin (FAD)-dependent enzyme found in two isozyme forms, MAO-A and MAO-B, and widely distributed in both the CNS and peripheral organs. In contrast, CYP exists in a wide variety of isozyme forms and is an NADP-dependent system. Also the greatest variety of CYP isozymes, at least the ones associated with the metabolism of xenobiotics, are found mostly in the liver and intestinal mucosa. MAO-A and MAO-B are coded by two genes, both on the X-chromosome and have about 70% amino acid sequence homology. Another difference between the CYP and MAO
families is cellular location. CYP enzymes are found on the endoplasmic reticulum of the cell's cytosol, whereas the MAO enzymes are on the outer mitochondrial membrane. In addition to the xenobiotics illustrated in the reaction schemes, other drugs metabolized by the MAO system include phenylephrine, propranolol, timolol and other ^-adrenergic agonists and antagonists, and various phenylethylamines.206 Structural features, especially the a-substituents of the primary amine, often determine whether carbon or nitrogen oxidation will occur. For example, compare amphetamine with its a--methyl homologue phentermine. In amphetamine, a--carbon hydroxylation can occur to form the carbinolamine intermediate, which is converted to the oxidatively deami-nated product phenylacetone.67 With phentermine, a-carbon hydroxylation is not possible and precludes oxidative deamination for this drug. Consequently, phentermine would be expected to undergo N-oxidation readily. In humans, p-hydroxylation and N-oxidation are the main pathways for biotransformation of phentermine.207
Indeed, N-hydroxyphentermine is an important (5%) urinary metabolite in humans.207 As discussed below, N-hydroxylamine metabolites are susceptible to further oxidation to yield other N-oxygenated products.
Enzymatic J)
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Go on the hunt again.
Posted By Ravi Sinha | On 07th, Aug. 2013 Under News
Arkane Studios' Dishonored is still going strong with The Brigmore Witches DLC coming up soon for release. However, it seems that plans are already in the pipeline for a Game of the Year Edition for the game, going by a recent trademark filed for the same.
It's more than likely that this will include all the DLC released till now including Dunwall City Trials, The Knife of Dunwall and the upcoming Brigmore Witches. The fourth unannounced DLC package will likely release before the Game of the Year edition but we don't put it past Zenimax to release both around the same time.
Published in 2012, Dishonored follows the journey of Corvo who seeks to unravel the mystery behind the death of the Queen in Dunwall while also rescuing her daughter Emily and freeing the city from oppression. Mixing first person stealth gameplay with supernatural powers, the game was critically and commercially acclaimed.
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